                         SEQUENCE LISTING

<110>  BioNTech SE
 
<120>  MONOCLONAL ANTIBODIES DIRECTED AGAINST PROGRAMMED DEATH-1 PROTEIN AND THEIR USE IN MEDICINE

<130>  674-388 PCT2

<150>  PCT/EP2020/081746
<151>  2020-11-11

<160>  107     

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  1

Ala Phe Tyr Asp Asp Tyr Asp Tyr Asn Val 
1               5                   10  


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  2

Asn Ser Gly Asp Ala Gln Phe Asn Ile 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  3

Ser Thr Thr Asp Ala Gln Phe Asn Ile 
1               5                   


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  4

Glu Ile Pro Tyr Phe Asn Val 
1               5           


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  5

Ala Gly Tyr Val Gly Ala Val Tyr Val Thr Leu Thr Arg Leu Asp Leu 
1               5                   10                  15      


<210>  6
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  6

Ala Arg Ala Phe Tyr Asp Asp Tyr Asp Tyr Asn Val 
1               5                   10          


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  7

Ala Arg Asn Ser Gly Asp Ala Gln Phe Asn Ile 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  8

Ala Arg Ser Thr Thr Asp Ala Gln Phe Asn Ile 
1               5                   10      


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  9

Ala Thr Glu Ile Pro Tyr Phe Asn Val 
1               5                   


<210>  10
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  10

Ala Arg Ala Gly Tyr Val Gly Ala Val Tyr Val Thr Leu Thr Arg Leu 
1               5                   10                  15      


Asp Leu 
        


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  11

Ile Ile Ser Gly Gly Thr Ile Gly 
1               5               


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  12

Ser Phe Tyr Ala Asp Ser Gly Thr Thr 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  13

Ile Ile Tyr Pro Asp Thr Gly Thr Thr 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  14

Ile Gly Ile Gly Gly Ser Gly Ser Thr 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  15

Ile Tyr Val Gly Ser Ser Gly Val Ser 
1               5                   


<210>  16
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  16

Ile Ile Ser Gly Gly Thr Ile Gly His Tyr Ala Ser Trp Ala Lys Gly 
1               5                   10                  15      


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  17

Ser Phe Tyr Ala Asp Ser Gly Thr Thr Trp Tyr Ala Thr Trp Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  18

Ile Ile Tyr Pro Asp Thr Gly Thr Thr Trp Tyr Ala Ser Trp Val Lys 
1               5                   10                  15      


Gly 
    


<210>  19
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  19

Cys Ile Gly Ile Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Gly Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  20
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  20

Cys Ile Tyr Val Gly Ser Ser Gly Val Ser Tyr Tyr Ala Thr Trp Ala 
1               5                   10                  15      


Lys Gly 
        


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  21

Asp Thr Tyr Trp 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  22

Ser Val Tyr Tyr 
1               


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  23

Ser Tyr Asn Met Gly 
1               5   


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  24

Arg Tyr Tyr Ile Ser 
1               5   


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  25

Arg Tyr Tyr Met Thr 
1               5   


<210>  26
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  26

Asp Thr Tyr Trp Ile Cys 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  27

Ser Val Tyr Tyr Met Cys 
1               5       


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  28

Gly Phe Ser Leu Tyr Ser Tyr Asn 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  29

Gly Phe Ser Leu Ser Arg Tyr Tyr 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  30

Gly Phe Ser Leu Ser Arg Tyr Tyr 
1               5               


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  31

Gly Ile Asp Phe Ser Asp Thr Tyr Trp 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  32

Gly Ile Asp Phe Ser Ser Val Tyr Tyr 
1               5                   


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  33

Ala Gly Gly Tyr Ser Ser Ser Ser Asp Thr Thr 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  34

Ala Gly Gly Tyr Ser Val Thr Ser Asp Thr Thr 
1               5                   10      


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  35

Ala Gly Gly Tyr Ser Thr Thr Ser Asp Thr Thr 
1               5                   10      


<210>  36
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  36

Gln Gly Thr Tyr Asp Val Asn Gly Trp Leu Val Ala 
1               5                   10          


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  37

Leu Gly Gly Tyr Asp Asp Asp Ala Asp Asn Ala 
1               5                   10      


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  38

Gln Ala Ser Lys Leu Glu Thr 
1               5           


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  39

Asp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  40

Asp Ala Ser Lys Leu Thr Ser 
1               5           


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  41

Asp Ala Ser Lys Leu Ala Ser 
1               5           


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  42

Gln Ser Val Tyr Gly Asn Asn Gln 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  43

Glu Ser Val Tyr Asn Lys Asn Gln 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  44

Glu Asn Val Tyr Thr Asp Asn Gln 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  45

Gln Ser Val Tyr Asn Lys Asn Trp 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  46

Gln Ser Ile Tyr Thr Asn Asn Asp 
1               5               


<210>  47
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  47

Gln Ser Ser Gln Ser Val Tyr Gly Asn Asn Gln Leu Ser 
1               5                   10              


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  48

Gln Ser Ser Glu Ser Val Tyr Asn Lys Asn Gln Leu Cys 
1               5                   10              


<210>  49
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  49

Gln Ser Ser Glu Asn Val Tyr Thr Asp Asn Gln Leu Cys 
1               5                   10              


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  50

Gln Ser Ser Gln Ser Val Tyr Asn Lys Asn Trp Leu Ala 
1               5                   10              


<210>  51
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Complementarity determining region (CDR)

<400>  51

Gln Ser Ser Gln Ser Ile Tyr Thr Asn Asn Asp Leu Ala 
1               5                   10              



<210>  52
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0202)

<400>  52

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Tyr Ser Tyr Asn 
            20                  25                  30          


Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
        35                  40                  45              


Ile Ile Ser Gly Gly Thr Ile Gly His Tyr Ala Ser Trp Ala Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys Met 
65                  70                  75                  80  


Thr Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg Ala 
                85                  90                  95      


Phe Tyr Asp Asp Tyr Asp Tyr Asn Val Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  53
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH)(MAB-19-0208)

<400>  53

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr Tyr 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ser Phe Tyr Ala Asp Ser Gly Thr Thr Trp Tyr Ala Thr Trp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Phe Ser Thr Ala Ser Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Met Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Asn Ser Gly Asp Ala Gln Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  54
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0217)

<400>  54

Gln Ser Val Glu Glu Ser Gly Gly Arg Leu Val Thr Pro Gly Thr Pro 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg Tyr Tyr 
            20                  25                  30          


Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ile Ile Tyr Pro Asp Thr Gly Thr Thr Trp Tyr Ala Ser Trp Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Phe Ser Lys Thr Ser Ser Thr Thr Val Asp Leu Lys 
65                  70                  75                  80  


Met Thr Ser Pro Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Ser Thr Thr Asp Ala Gln Phe Asn Ile Trp Gly Pro Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  55
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0223)

<400>  55

Gln Glu His Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Glu Gly 
1               5                   10                  15      


Ser Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Asp Thr 
            20                  25                  30          


Tyr Trp Ile Cys Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Cys Ile Gly Ile Gly Gly Ser Gly Ser Thr Tyr Tyr Ala Gly 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val 
65                  70                  75                  80  


Thr Leu Gln Met Thr Thr Leu Thr Asp Ala Asp Thr Ala Thr Tyr Phe 
                85                  90                  95      


Cys Ala Thr Glu Ile Pro Tyr Phe Asn Val Trp Gly Pro Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  56
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0233)

<400>  56

Gln Ser Leu Glu Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Ala Ser 
1               5                   10                  15      


Leu Thr Leu Thr Cys Lys Ala Ser Gly Ile Asp Phe Ser Ser Val Tyr 
            20                  25                  30          


Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ala Cys Ile Tyr Val Gly Ser Ser Gly Val Ser Tyr Tyr Ala Thr Trp 
    50                  55                  60                  


Ala Lys Gly Arg Phe Thr Ile Ser Lys Thr Ser Ser Thr Thr Val Thr 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ala Gly Tyr Val Gly Ala Val Tyr Val Thr Leu Thr Arg Leu 
            100                 105                 110         


Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 



<210>  57
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0202)

<400>  57

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Lys Leu Glu Thr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Leu 
65                  70                  75                  80  


Glu Ser Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  58
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0208)

<400>  58

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Ser Val Tyr Asn Lys 
            20                  25                  30          


Asn Gln Leu Cys Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Asp Val 
65                  70                  75                  80  


Gln Ser Asp Ala Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Val 
                85                  90                  95      


Thr Ser Asp Thr Thr Phe Gly Gly Gly Thr Glu Val Val Val Arg 
            100                 105                 110     


<210>  59
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0217)

<400>  59

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Ser Ile Ser Cys Gln Ser Ser Glu Asn Val Tyr Thr Asp 
            20                  25                  30          


Asn Gln Leu Cys Trp Tyr Gln Gln Lys Pro Gly Gln Arg Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Ser Asp Asp Ala Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Thr 
                85                  90                  95      


Thr Ser Asp Thr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  60
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0223)

<400>  60

Ala Gln Val Leu Thr Gln Thr Pro Ser Ser Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Asn Cys Gln Ser Ser Gln Ser Val Tyr Asn Lys 
            20                  25                  30          


Asn Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Thr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Lys Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Ser Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gly Thr Tyr Asp Val 
                85                  90                  95      


Asn Gly Trp Leu Val Ala Phe Gly Gly Gly Ala Glu Val Val Val Lys 
            100                 105                 110         


<210>  61
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0233)

<400>  61

Ala Ala Val Leu Thr Gln Thr Pro Ser Pro Val Ser Ala Ala Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Ser Cys Gln Ser Ser Gln Ser Ile Tyr Thr Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Ser Asp Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  62
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (H5) (derived from MAB-19-0202)

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Val Ser Gly Phe Ser Leu Tyr Ser Tyr 
            20                  25                  30          


Asn Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Ile Ile Ser Gly Gly Thr Ile Gly His Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Thr Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Phe Tyr Asp Asp Tyr Asp Tyr Asn Val Trp Gly Pro Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  63
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (H5) (derived from MAB-19-0233)

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Asp Val Val Lys Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Ile Asp Phe Ser Ser Val 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Cys Ile Tyr Val Gly Ser Ser Gly Val Ser Tyr Tyr Ala Thr 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Thr Ser Thr 
65                  70                  75                  80  


Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Gly Tyr Val Gly Ala Val Tyr Val Thr Leu Thr 
            100                 105                 110         


Arg Leu Asp Leu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  64
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (H1) (derived from MAB-19-0233)

<400>  64

Glu Val Gln Leu Glu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Asp Phe Ser Ser Val 
            20                  25                  30          


Tyr Tyr Met Cys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ser Cys Ile Tyr Val Gly Ser Ser Gly Val Ser Tyr Tyr Ala Thr 
    50                  55                  60                  


Trp Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Ala Gly Tyr Val Gly Ala Val Tyr Val Thr Leu Thr 
            100                 105                 110         


Arg Leu Asp Leu Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  65
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L1) (derived from MAB-19-0202)

<400>  65

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Lys Leu Glu Thr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Thr Phe Gly Gly Gly Thr Lys Val Val Ile Lys 
            100                 105                 110     


<210>  66
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L2) (derived from MAB-19-0202)

<400>  66

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Lys Leu Glu Thr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Asp Asp Phe Ala Ser Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  67
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L3) (derived from MAB-19-0202)

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Lys Lys Pro Gly Gln Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Lys Leu Glu Thr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105                 110     


<210>  68
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L4) (derived from MAB-19-0202)

<400>  68

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Val Tyr Gly Asn 
            20                  25                  30          


Asn Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gln Ala Ser Lys Leu Glu Thr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Arg Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Tyr Ser Ser 
                85                  90                  95      


Ser Ser Asp Thr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     


<210>  69
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L1) (derived from MAB-19-0233)

<400>  69

Asp Val Val Met Thr Gln Ser Pro Ser Thr Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Thr Cys Gln Ser Ser Gln Ser Ile Tyr Thr Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Ala Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Ala Asp Asn Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  70
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L4) (derived from MAB-19-0233)

<400>  70

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Gly Thr Val Thr Ile Thr Cys Gln Ser Ser Gln Ser Ile Tyr Thr Asn 
            20                  25                  30          


Asn Asp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Gln Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Ser Glu Asp Ala Ala Thr Tyr Tyr Cys Leu Gly Gly Tyr Asp Asp 
                85                  90                  95      


Asp Ala Asp Asn Ala Phe Gly Gly Gly Thr Glu Val Val Val Lys 
            100                 105                 110     



<210>  71
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro 
145                 150                 155                 160 


Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Val Gly Val Val Gly Gly 
                165                 170                 175     


Leu Leu Gly Ser Leu Val Leu Leu Val Trp Val Leu Ala Val Ile Cys 
            180                 185                 190         


Ser Arg Ala Ala Arg Gly Thr Ile Gly Ala Arg Arg Thr Gly Gln Pro 
        195                 200                 205             


Leu Lys Glu Asp Pro Ser Ala Val Pro Val Phe Ser Val Asp Tyr Gly 
    210                 215                 220                 


Glu Leu Asp Phe Gln Trp Arg Glu Lys Thr Pro Glu Pro Pro Val Pro 
225                 230                 235                 240 


Cys Val Pro Glu Gln Thr Glu Tyr Ala Thr Ile Val Phe Pro Ser Gly 
                245                 250                 255     


Met Gly Thr Ser Ser Pro Ala Arg Arg Gly Ser Ala Asp Gly Pro Arg 
            260                 265                 270         


Ser Ala Gln Pro Leu Arg Pro Glu Asp Gly His Cys Ser Trp Pro Leu 
        275                 280                 285             


<210>  72
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  72

Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly Gln Phe Gln 
    130                 135                 140                 


Thr Leu Val 
145         


<210>  73
<211>  2115
<212>  DNA
<213>  Homo sapiens

<400>  73
agtttccctt ccgctcacct ccgcctgagc agtggagaag gcggcactct ggtggggctg       60

ctccaggcat gcagatccca caggcgccct ggccagtcgt ctgggcggtg ctacaactgg      120

gctggcggcc aggatggttc ttagactccc cagacaggcc ctggaacccc cccaccttct      180

ccccagccct gctcgtggtg accgaagggg acaacgccac cttcacctgc agcttctcca      240

acacatcgga gagcttcgtg ctaaactggt accgcatgag ccccagcaac cagacggaca      300

agctggccgc cttccccgag gaccgcagcc agcccggcca ggactgccgc ttccgtgtca      360

cacaactgcc caacgggcgt gacttccaca tgagcgtggt cagggcccgg cgcaatgaca      420

gcggcaccta cctctgtggg gccatctccc tggcccccaa ggcgcagatc aaagagagcc      480

tgcgggcaga gctcagggtg acagagagaa gggcagaagt gcccacagcc caccccagcc      540

cctcacccag gccagccggc cagttccaaa ccctggtggt tggtgtcgtg ggcggcctgc      600

tgggcagcct ggtgctgcta gtctgggtcc tggccgtcat ctgctcccgg gccgcacgag      660

ggacaatagg agccaggcgc accggccagc ccctgaagga ggacccctca gccgtgcctg      720

tgttctctgt ggactatggg gagctggatt tccagtggcg agagaagacc ccggagcccc      780

ccgtgccctg tgtccctgag cagacggagt atgccaccat tgtctttcct agcggaatgg      840

gcacctcatc ccccgcccgc aggggctcag ctgacggccc tcggagtgcc cagccactga      900

ggcctgagga tggacactgc tcttggcccc tctgaccggc ttccttggcc accagtgttc      960

tgcagaccct ccaccatgag cccgggtcag cgcatttcct caggagaagc aggcagggtg     1020

caggccattg caggccgtcc aggggctgag ctgcctgggg gcgaccgggg ctccagcctg     1080

cacctgcacc aggcacagcc ccaccacagg actcatgtct caatgcccac agtgagccca     1140

ggcagcaggt gtcaccgtcc cctacaggga gggccagatg cagtcactgc ttcaggtcct     1200

gccagcacag agctgcctgc gtccagctcc ctgaatctct gctgctgctg ctgctgctgc     1260

tgctgctgcc tgcggcccgg ggctgaaggc gccgtggccc tgcctgacgc cccggagcct     1320

cctgcctgaa cttgggggct ggttggagat ggccttggag cagccaaggt gcccctggca     1380

gtggcatccc gaaacgccct ggacgcaggg cccaagactg ggcacaggag tgggaggtac     1440

atggggctgg ggactcccca ggagttatct gctccctgca ggcctagaga agtttcaggg     1500

aaggtcagaa gagctcctgg ctgtggtggg cagggcagga aacccctcca cctttacaca     1560

tgcccaggca gcacctcagg ccctttgtgg ggcagggaag ctgaggcagt aagcgggcag     1620

gcagagctgg aggcctttca ggcccagcca gcactctggc ctcctgccgc cgcattccac     1680

cccagcccct cacaccactc gggagaggga catcctacgg tcccaaggtc aggagggcag     1740

ggctggggtt gactcaggcc cctcccagct gtggccacct gggtgttggg agggcagaag     1800

tgcaggcacc tagggccccc catgtgccca ccctgggagc tctccttgga acccattcct     1860

gaaattattt aaaggggttg gccgggctcc caccagggcc tgggtgggaa ggtacaggcg     1920

ttcccccggg gcctagtacc cccgccgtgg cctatccact cctcacatcc acacactgca     1980

cccccactcc tggggcaggg ccaccagcat ccaggcggcc agcaggcacc tgagtggctg     2040

ggacaaggga tcccccttcc ctgtggttct attatattat aattataatt aaatatgaga     2100

gcatgctaag gaaaa                                                      2115



<210>  74
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0202)

<400>  74
cagagcgtgg aagaatctgg cggcagactg gtcacacctg gcacacctct gacactgacc       60

tgtaccgtgt ccggcttcag cctgtacagc tacaacatgg gctgggtccg acaggcccct      120

ggaaagggac tcgagtacat cggcatcatc agcggcggca caatcggcca ctatgcctct      180

tgggccaagg gcagattcac catcagcaag accagcagca ccaccgtgga cctgaagatg      240

accagcctga ccaccgagga caccgccacc tacttttgcg ccagagcctt ctacgacgac      300

tacgactaca acgtgtgggg cccaggcaca ctcgtgacag tctcctct                   348


<210>  75
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0208)

<400>  75
cagagcgtgg aagaatctgg cggcagactg gtcacacctg gcacacctct gacactgacc       60

tgtaccgtgt ccggcttcag cctgagccgg tactacatca gctgggtccg acaggcccct      120

ggcaaaggac tggaatggat cggcagcttc tacgccgata gcggcacaac ttggtacgcc      180

acctgggtca agggcagatt cacctttagc accgccagca gcaccaccgt ggacctgaag      240

atgacaagcc ccaccaccga ggacaccgcc acctactttt gcgccagaaa cagcggcgac      300

gcccagttca atatctgggg ccctggaaca ctggtcaccg tgtcatct                   348


<210>  76
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0217)

<400>  76
cagagcgtgg aagaatctgg cggcagactg gtcacacctg gcacacctct gacactgacc       60

tgtaccgtgt ccggcttcag cctgagccgg tactacatga cctgggtccg acaggcccct      120

ggcaaaggac tggaatggat cggcatcatc taccccgaca ccggcacaac ttggtacgcc      180

tcttgggtca agggcagatt caccttcagc aagaccagca gcaccaccgt ggacctgaag      240

atgacaagcc ccaccaccga ggacaccgcc acctactttt gtgccagaag caccacagac      300

gcccagttca acatctgggg ccctggaaca ctggtcaccg tgtcatct                   348


<210>  77
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0223)

<400>  77
caagagcacc tggtggaatc tggcggagga ctggttcagc ctgagggctc tctgaccctg       60

acctgtaaag ccagcggcat cgacttcagc gacacctact ggatctgctg ggtccgacag      120

cctcctggca aaggcctgga atggatcggc tgtatcggca tcggcggcag cggcagcaca      180

tattatgccg gatgggccaa gggcagattc accatcagca agaccagcag caccaccgtg      240

acactgcaga tgaccacact gaccgacgcc gacaccgcca cctatttctg tgccaccgag      300

attccctact tcaacgtgtg gggccctggc acactggtca cagtctcttc t               351


<210>  78
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (VH) (MAB-19-0233)

<400>  78
cagagcctgg aagaatctgg cggcgatctt gtgaaacctg gcgcctctct gaccctgaca       60

tgtaaagcca gcggcatcga cttcagcagc gtgtactaca tgtgttgggt ccgacaggcc      120

cctggcaaag gcctggaatg gatcgcctgt atctacgtgg gcagcagcgg cgtgtcctac      180

tatgccacat gggccaaggg cagattcacc atcagcaaga ccagcagcac caccgtgaca      240

ctgcagatga catctctgac agccgccgac accgccacct acttttgtgc cagagccgga      300

tatgtgggcg ccgtgtatgt gacactgacc agactggatc tgtggggcca gggcacactg      360

gtcacagtct cctct                                                       375


<210>  79
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0202)

<400>  79
gctgctgtgc tgacccagac accttctcca gtgtctgccg ccgttggcgg cacagtgaca       60

atcagctgtc agagcagcca gagcgtgtac ggcaacaacc agctgtcctg gtatcagcag      120

aagcccggcc agcctcctaa gctgctgatc taccaggcca gcaagctgga aacaggcgtg      180

cccagcagat tcaaaggcag cggctctggc acccagttca ccctgacaat ctccgacctg      240

gaaagcgacg atgccgccac ctactattgt gccggcggat acagcagcag ctccgacaca      300

acatttggcg gcggaacaga ggtggtggtc aag                                   333


<210>  80
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0208)

<400>  80
gctgctgtgc tgacccagac accttctcca gtgtctgccg ctgttggcgg cacagtgtct       60

atcagctgtc agagcagcga gagcgtgtac aacaagaacc agctgtgctg gtatcagcag      120

aagcccggcc agaggcctaa gctgctgatc tacgatgcca gcacactggc cagcggagtg      180

cctagcagat tttctggcag cggctctggc acccagttca ccctgacaat ctccgacgtg      240

cagtctgatg ccgccgctac ctactattgt gccggcggat acagcgtgac cagcgacaca      300

acatttggcg gcggaacaga ggtggtcgtc aga                                   333


<210>  81
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0217)

<400>  81
gctgctgtgc tgacccagac accttctcca gtgtctgccg ctgttggcgg cacagtgtct       60

atcagctgtc agagcagcga gaacgtgtac accgacaacc agctgtgctg gtatcagcag      120

aagcctggcc agaggcctaa gctgctgatc tacgatgcca gcacactggc cagcggagtg      180

cctagcagat tttctggcag cggctctggc acccagttca ccctgacaat tagcggcgtg      240

cagtccgatg atgccgccac ctattattgc gctggcggct acagcaccac cagcgataca      300

acatttggcg gcggaaccga ggtggtggtc aaa                                   333


<210>  82
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0223)

<400>  82
gctcaggtgc tgacacagac acctagctct gtgtctgccg ccgttggcgg caccgtgacc       60

atcaattgtc agagcagcca gagcgtgtac aacaagaact ggctggcctg gtatcagcag      120

aagcctggcc agcctcctaa gctgctgatc tacgatgcca gcaagctgac cagcggcgtg      180

ccctctagat tcaaaggctc tggcagcggc acccagttca ccctgacaat ttctggcgtg      240

cagagcgacg acgccgccac ctattattgc caaggcacct acgacgtgaa cggctggctg      300

gttgcttttg gaggcggagc cgaagtggtg gtcaaa                                336


<210>  83
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (VL) (MAB-19-0233)

<400>  83
gctgctgtgc tgacccagac accttctcca gtgtctgccg ccgttggcgg cacagtgaca       60

atcagctgtc agagcagcca gagcatctac accaacaacg acctggcctg gtatcagcag      120

aagcctggcc agcctcctaa gctgctgatc tacgatgcca gcaagctggc ctctggcgtg      180

ccaagcagat tttctggcag cggctctggc acccagttca ccctgacaat tagcggcgtg      240

cagtccgatg atgccgccac ctattattgc ctcggcggct acgatgacga cgccgacaat      300

gcttttggcg gcggaacaga ggtggtggtc aaa                                   333


<210>  84
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (H5) (derived from MAB-19-0202)

<400>  84
caggtgcagc tggttgaatc tggcggagga ctggtgcagc ctggcacatc tctgagactg       60

agctgtagcg tgtccggctt cagcctgtac agctacaaca tgggctgggt ccgacaggcc      120

cctggaaagg gactcgagta catcggcatc atcagcggcg gcacaatcgg ccactatgcc      180

tcttgggcca agggcagatt caccatcagc cgggacacca gcaagaccac actgtacctg      240

cagatgaaca gcctgaccac cgaggacacc gccacctact tttgcgccag agccttctac      300

gacgactacg actacaacgt gtggggccct ggcacactgg tcacagtctc ttct            354


<210>  85
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (H5) (derived from MAB-19-0233)

<400>  85
caggtgcagc tggttgagtc tggcggagat gtggtcaagc ctggcagaag cctgagactg       60

agctgtaaag ccagcggcat cgacttcagc agcgtgtact acatgtgctg ggtccgacag      120

gcccctggca aaggactgga atggatcgcc tgtatctacg tgggcagcag cggcgtgtcc      180

tactatgcca catgggccaa gggcagattc accatcagcc gggacacctc taccagcaca      240

ctgtttctgc agatgaacag cctgagagcc ggcgacacag ccacctacta ttgtgccaga      300

gccggctatg tgggcgccgt gtatgtgacc ctgaccagac tggatctgtg gggccaggga      360

acactggtca cagtgtcatc t                                                381


<210>  86
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable region (H1) (derived from MAB-19-0233)

<400>  86
gaggtgcagc tggaagaatc tggcggcgga cttgtgaagc ctggcggatc tctgagactg       60

agctgtgccg cctctggcat cgatttcagc agcgtgtact acatgtgctg ggtccgacag      120

gcccctggca aaggacttga atgggtgtcc tgcatctacg tgggcagcag cggcgtgtcc      180

tactatgcca catgggccaa gggcagattc accatcagcc gggacaacag caagaacacc      240

ctgtacctgc agatgaacag cctgagagcc gaggacaccg ccgtgtacta ttgtgccaga      300

gccggatatg tgggcgccgt gtatgtgacc ctgaccagac tggatctgtg gggcagaggc      360

acactggtca cagtgtcatc t                                                381


<210>  87
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L1) (derived from MAB-19-0202)

<400>  87
gacatcgtga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacctgtc agagcagcca gagcgtgtac ggcaacaacc agctgtcctg gtatcagcag      120

aagcccggca aggcccctaa gctgctgatc taccaggcca gcaagctgga aacaggcgtg      180

cccagcagat tttctggcag cggctctggc accgacttca ccctgaccat atctagcctg      240

cagcctgagg acttcgccac ctactattgt gccggcggat acagcagcag ctccgacaca      300

acatttggcg gaggcaccaa ggtggtcatc aag                                   333


<210>  88
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L2) (derived from MAB-19-0202)

<400>  88
gacatccaga tgacacagag ccccagcaca ctgtctgcca gcgtgggaga cagagtgacc       60

atcacctgtc agagcagcca gagcgtgtac ggcaacaacc agctgtcctg gtatcagcag      120

aagcccggca aggcccctaa gctgctgatc taccaggcca gcaagctgga aacaggcgtg      180

cccagcagat tttctggcag cggctctggc acccagttca ccctgaccat cagtagcctg      240

cagcctgacg acttcgccag ctactattgt gccggcggat acagcagcag ctccgatacc      300

acatttggcc agggcaccaa ggtggaaatc aag                                   333


<210>  89
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L3) (derived from MAB-19-0202)

<400>  89
gacatccaga tgacacagag ccctagcagc ctgtctgcca gcgtgggaga cagagtgacc       60

atcacctgtc agagcagcca gagcgtgtac ggcaacaacc agctgtcctg gtatcagaag      120

aagcccggac aggcccctaa gctgctgatc taccaggcca gcaagctgga aacaggcgtg      180

cccagcagat tttctggcag cggctctggc accgacttca ccctgaccat atctagcctg      240

cagcctgagg acttcgccac ctactattgt gccggcggat acagcagcag ctccgacaca      300

acatttggcc ctggcaccaa ggtggacatc aag                                   333


<210>  90
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L4) (derived from MAB-19-0202)

<400>  90
gccattcagc tgacacagag cccttctagc ctgagcgcct ctgttggcgg caccgtgaca       60

atcacctgtc agagcagcca gagcgtgtac ggcaacaacc agctgtcctg gtatcagcag      120

aagcccggcc agcctcctaa gctgctgatc taccaggcca gcaagctgga aacaggcgtg      180

ccctctagat tcagaggcag cggctctggc acccagttca cactgacaat cagcagcctg      240

cagagcgagg acttcgccac ctactattgt gccggcggat acagcagcag ctccgacaca      300

acatttggcg gcggaacaga ggtggtggtc aag                                   333


<210>  91
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L1) (derived from MAB-19-0233)

<400>  91
gacgtggtca tgacacagag ccctagcaca gtgtctgcca gcgtgggcga tagagtgacc       60

ctgacctgtc agagcagcca gagcatctac accaacaacg acctggcctg gtatcagcag      120

aagcctggcc agcctcctaa gctgctgatc tacgatgcca gcaagctggc ctctggcgtg      180

cccgatagat tttctggcag cggctctggc accgacttca ccctgacaat tagctccctg      240

caggccgacg acttcgccac ctattattgt ctcggcggct acgacgacga cgccgataat      300

gcttttggcc agggcaccaa ggtggaaatc aag                                   333


<210>  92
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable region (L4) (derived from MAB-19-0233)

<400>  92
gacatccaga tgacacagag ccctagcagc ctgtctgcct ctgttggcgg caccgtgaca       60

atcacctgtc agagcagcca gagcatctac accaacaacg acctggcctg gtatcagcag      120

aagcctggcc agcctcctaa gctgctgatc tacgatgcca gcaagctggc ctctggcgtg      180

ccaagcagat tttctggcag cggctctggc acccagttca ccctgacaat ctctagcctg      240

cagagcgagg atgccgccac ctactattgt ctcggcggct acgacgacga cgccgacaat      300

gcttttggcg gcggaacaga ggtggtggtc aaa                                   333


<210>  93
<211>  1886
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pST4-vector (HC; RiboMab-19-0202)

<400>  93
attcttctgg tccccacaga ctcagagaga acccgccacc atgagagtga tggcccccag       60

aaccctgatc ctgctgctgt ctggcgccct ggccctgaca gagacatggg ccggaagcca      120

gagcgtggaa gaatctggcg gcagactggt cacacctggc acacctctga cactgacctg      180

taccgtgtcc ggcttcagcc tgtacagcta caacatgggc tgggtccgac aggcccctgg      240

aaagggactc gagtacatcg gcatcatcag cggcggcaca atcggccact atgcctcttg      300

ggccaagggc agattcacca tcagcaagac cagcagcacc accgtggacc tgaagatgac      360

cagcctgacc accgaggaca ccgccaccta cttttgcgcc agagccttct acgacgacta      420

cgactacaac gtgtggggcc caggcacact cgtgacagtc tcctctgcct ctacaaaggg      480

ccctagcgtg ttccctctgg ctcctagcag caagtctaca agcggaggaa cagccgctct      540

gggctgcctg gtcaaggatt actttcccga gcctgtgacc gtgtcctgga attctggcgc      600

tctgacaagc ggcgtgcaca cctttccagc tgtgctgcaa agcagcggcc tgtactctct      660

gagcagcgtg gtcacagtgc caagctctag cctgggcacc cagacctaca tctgcaatgt      720

gaaccacaag cctagcaaca ccaaggtgga caagaaggtg gaacccaaga gctgcgacaa      780

gacccacacc tgtcctccat gtcctgctcc agaagctgct ggcggccctt ccgtgtttct      840

gttccctcca aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgcgt      900

ggtggtggat gtgtcccacg aggatcccga agtgaagttc aattggtacg tggacggcgt      960

ggaagtgcac aacgccaaga ccaagcctag agaggaacag tacaacagca cctacagagt     1020

ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac ggcaaagagt acaagtgcaa     1080

ggtgtccaac aaggccctgg gcgctcccat cgagaaaacc atctctaagg ccaagggaca     1140

gccccgcgaa cctcaggttt acacactgcc tccaagccgg gaagaaatga ccaagaacca     1200

ggtgtccctg acctgcctcg tgaagggctt ctacccttcc gatatcgccg tggaatggga     1260

gagcaatggc cagcctgaga acaactacaa gacaacccct cctgtgctgg actccgatgg     1320

ctcattcttc ctgtacagca agctgacagt ggacaagtcc agatggcagc agggcaacgt     1380

gttcagctgc agcgtgatgc acgaggccct gcacaaccac tacacccaga agtccctgag     1440

cctgtctcct ggatgatgac tcgagctggt actgcatgca cgcaatgcta gctgcccctt     1500

tcccgtcctg ggtaccccga gtctcccccg acctcgggtc ccaggtatgc tcccacctcc     1560

acctgcccca ctcaccacct ctgctagttc cagacacctc ccaagcacgc agcaatgcag     1620

ctcaaaacgc ttagcctagc cacaccccca cgggaaacag cagtgattaa cctttagcaa     1680

taaacgaaag tttaactaag ctatactaac cccagggttg gtcaatttcg tgccagccac     1740

accgagacct ggtccagagt cgctagccgc gtcgctaaaa aaaaaaaaaa aaaaaaaaaa     1800

aaaaaagcat atgactaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          1886


<210>  94
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-UTR

<400>  94
attcttctgg tccccacaga ctcagagaga accc                                   34


<210>  95
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozac sequence

<400>  95
gccacc                                                                   6


<210>  96
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  signal peptide sequence

<400>  96
atgagagtga tggcccccag aaccctgatc ctgctgctgt ctggcgccct ggccctgaca       60

gagacatggg ccggaagc                                                     78


<210>  97
<211>  294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constant domain CH1

<400>  97
gcctctacaa agggccctag cgtgttccct ctggctccta gcagcaagtc tacaagcgga       60

ggaacagccg ctctgggctg cctggtcaag gattactttc ccgagcctgt gaccgtgtcc      120

tggaattctg gcgctctgac aagcggcgtg cacacctttc cagctgtgct gcaaagcagc      180

ggcctgtact ctctgagcag cgtggtcaca gtgccaagct ctagcctggg cacccagacc      240

tacatctgca atgtgaacca caagcctagc aacaccaagg tggacaagaa ggtg            294


<210>  98
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hinge region

<400>  98
gaacccaaga gctgcgacaa gacccacacc tgtcctccat gtcct                       45


<210>  99
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constant domain CH2

<400>  99
gctccagaag ctgctggcgg cccttccgtg tttctgttcc ctccaaagcc taaggacacc       60

ctgatgatca gcagaacccc tgaagtgacc tgcgtggtgg tggatgtgtc ccacgaggat      120

cccgaagtga agttcaattg gtacgtggac ggcgtggaag tgcacaacgc caagaccaag      180

cctagagagg aacagtacaa cagcacctac agagtggtgt ccgtgctgac cgtgctgcac      240

caggattggc tgaacggcaa agagtacaag tgcaaggtgt ccaacaaggc cctgggcgct      300

cccatcgaga aaaccatctc taaggccaag                                       330


<210>  100
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constant domain CH3

<400>  100
ggacagcccc gcgaacctca ggtttacaca ctgcctccaa gccgggaaga aatgaccaag       60

aaccaggtgt ccctgacctg cctcgtgaag ggcttctacc cttccgatat cgccgtggaa      120

tgggagagca atggccagcc tgagaacaac tacaagacaa cccctcctgt gctggactcc      180

gatggctcat tcttcctgta cagcaagctg acagtggaca agtccagatg gcagcagggc      240

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagtcc      300

ctgagcctgt ctcctgga                                                    318


<210>  101
<211>  136
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  F-element

<400>  101
ctggtactgc atgcacgcaa tgctagctgc ccctttcccg tcctgggtac cccgagtctc       60

ccccgacctc gggtcccagg tatgctccca cctccacctg ccccactcac cacctctgct      120

agttccagac acctcc                                                      136


<210>  102
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  I-element

<400>  102
caagcacgca gcaatgcagc tcaaaacgct tagcctagcc acacccccac gggaaacagc       60

agtgattaac ctttagcaat aaacgaaagt ttaactaagc tatactaacc ccagggttgg      120

tcaatttcgt gccagccaca cc                                               142


<210>  103
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  poly(A) tail

<400>  103
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa gcatatgact aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                 110


<210>  104
<211>  1205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pST4-vector (LC; RiboMab-19-0202)

<400>  104
attcttctgg tccccacaga ctcagagaga acccgccacc atgagagtga tggcccccag       60

aaccctgatc ctgctgctgt ctggcgccct ggccctgaca gagacatggg ccggaagcgc      120

tgctgtgctg acccagacac cttctccagt gtctgccgcc gttggcggca cagtgacaat      180

cagctgtcag agcagccaga gcgtgtacgg caacaaccag ctgtcctggt atcagcagaa      240

gcccggccag cctcctaagc tgctgatcta ccaggccagc aagctggaaa caggcgtgcc      300

cagcagattc aaaggcagcg gctctggcac ccagttcacc ctgacaatct ccgacctgga      360

aagcgacgat gccgccacct actattgtgc cggcggatac agcagcagct ccgacacaac      420

atttggcggc ggaacagagg tggtggtcaa gcgtacggtg gccgctccta gcgtgttcat      480

cttcccacct tccgacgagc agctgaagtc tggcacagcc agcgttgtgt gcctgctgaa      540

caacttctac cccagagaag ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg      600

caatagccaa gagagcgtga ccgagcagga cagcaaggac tctacctaca gcctgagcag      660

caccctgaca ctgagcaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac      720

ccaccagggc ctttctagcc ctgtgaccaa gagcttcaac cggggcgaat gttgatgact      780

cgagctggta ctgcatgcac gcaatgctag ctgccccttt cccgtcctgg gtaccccgag      840

tctcccccga cctcgggtcc caggtatgct cccacctcca cctgccccac tcaccacctc      900

tgctagttcc agacacctcc caagcacgca gcaatgcagc tcaaaacgct tagcctagcc      960

acacccccac gggaaacagc agtgattaac ctttagcaat aaacgaaagt ttaactaagc     1020

tatactaacc ccagggttgg tcaatttcgt gccagccaca ccgagacctg gtccagagtc     1080

gctagccgcg tcgctaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagcata tgactaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaa                                                                 1205


<210>  105
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constant domain CL kappa

<400>  105
cgtacggtgg ccgctcctag cgtgttcatc ttcccacctt ccgacgagca gctgaagtct       60

ggcacagcca gcgttgtgtg cctgctgaac aacttctacc ccagagaagc caaggtgcag      120

tggaaggtgg acaacgccct gcagagcggc aatagccaag agagcgtgac cgagcaggac      180

agcaaggact ctacctacag cctgagcagc accctgacac tgagcaaggc cgactacgag      240

aagcacaaag tgtacgcctg cgaagtgacc caccagggcc tttctagccc tgtgaccaag      300

agcttcaacc ggggcgaatg t                                                321


<210>  106
<211>  1913
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pST4-vector (HC; RiboMab-19-0233)

<400>  106
attcttctgg tccccacaga ctcagagaga acccgccacc atgagagtga tggcccccag       60

aaccctgatc ctgctgctgt ctggcgccct ggccctgaca gagacatggg ccggaagcca      120

gagcctggaa gaatctggcg gcgatcttgt gaaacctggc gcctctctga ccctgacatg      180

taaagccagc ggcatcgact tcagcagcgt gtactacatg tgttgggtcc gacaggcccc      240

tggcaaaggc ctggaatgga tcgcctgtat ctacgtgggc agcagcggcg tgtcctacta      300

tgccacatgg gccaagggca gattcaccat cagcaagacc agcagcacca ccgtgacact      360

gcagatgaca tctctgacag ccgccgacac cgccacctac ttttgtgcca gagccggata      420

tgtgggcgcc gtgtatgtga cactgaccag actggatctg tggggccagg gcacactggt      480

cacagtctcc tctgcctcta caaagggccc tagcgtgttc cctctggctc ctagcagcaa      540

gtctacaagc ggaggaacag ccgctctggg ctgcctggtc aaggattact ttcccgagcc      600

tgtgaccgtg tcctggaatt ctggcgctct gacaagcggc gtgcacacct ttccagctgt      660

gctgcaaagc agcggcctgt actctctgag cagcgtggtc acagtgccaa gctctagcct      720

gggcacccag acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa      780

gaaggtggaa cccaagagct gcgacaagac ccacacctgt cctccatgtc ctgctccaga      840

agctgctggc ggcccttccg tgtttctgtt ccctccaaag cctaaggaca ccctgatgat      900

cagcagaacc cctgaagtga cctgcgtggt ggtggatgtg tcccacgagg atcccgaagt      960

gaagttcaat tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga     1020

ggaacagtac aacagcacct acagagtggt gtccgtgctg accgtgctgc accaggattg     1080

gctgaacggc aaagagtaca agtgcaaggt gtccaacaag gccctgggcg ctcccatcga     1140

gaaaaccatc tctaaggcca agggacagcc ccgcgaacct caggtttaca cactgcctcc     1200

aagccgggaa gaaatgacca agaaccaggt gtccctgacc tgcctcgtga agggcttcta     1260

cccttccgat atcgccgtgg aatgggagag caatggccag cctgagaaca actacaagac     1320

aacccctcct gtgctggact ccgatggctc attcttcctg tacagcaagc tgacagtgga     1380

caagtccaga tggcagcagg gcaacgtgtt cagctgcagc gtgatgcacg aggccctgca     1440

caaccactac acccagaagt ccctgagcct gtctcctgga tgatgactcg agctggtact     1500

gcatgcacgc aatgctagct gcccctttcc cgtcctgggt accccgagtc tcccccgacc     1560

tcgggtccca ggtatgctcc cacctccacc tgccccactc accacctctg ctagttccag     1620

acacctccca agcacgcagc aatgcagctc aaaacgctta gcctagccac acccccacgg     1680

gaaacagcag tgattaacct ttagcaataa acgaaagttt aactaagcta tactaacccc     1740

agggttggtc aatttcgtgc cagccacacc gagacctggt ccagagtcgc tagccgcgtc     1800

gctaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagcatatg actaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1913


<210>  107
<211>  1205
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pST4-vector (LC; RiboMab-19-0233)

<400>  107
attcttctgg tccccacaga ctcagagaga acccgccacc atgagagtga tggcccccag       60

aaccctgatc ctgctgctgt ctggcgccct ggccctgaca gagacatggg ccggaagcgc      120

tgctgtgctg acccagacac cttctccagt gtctgccgcc gttggcggca cagtgacaat      180

cagctgtcag agcagccaga gcatctacac caacaacgac ctggcctggt atcagcagaa      240

gcctggccag cctcctaagc tgctgatcta cgatgccagc aagctggcct ctggcgtgcc      300

aagcagattt tctggcagcg gctctggcac ccagttcacc ctgacaatta gcggcgtgca      360

gtccgatgat gccgccacct attattgcct cggcggctac gatgacgacg ccgacaatgc      420

ttttggcggc ggaacagagg tggtggtcaa acgtacggtg gccgctccta gcgtgttcat      480

cttcccacct tccgacgagc agctgaagtc tggcacagcc agcgttgtgt gcctgctgaa      540

caacttctac cccagagaag ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg      600

caatagccaa gagagcgtga ccgagcagga cagcaaggac tctacctaca gcctgagcag      660

caccctgaca ctgagcaagg ccgactacga gaagcacaaa gtgtacgcct gcgaagtgac      720

ccaccagggc ctttctagcc ctgtgaccaa gagcttcaac cggggcgaat gttgatgact      780

cgagctggta ctgcatgcac gcaatgctag ctgccccttt cccgtcctgg gtaccccgag      840

tctcccccga cctcgggtcc caggtatgct cccacctcca cctgccccac tcaccacctc      900

tgctagttcc agacacctcc caagcacgca gcaatgcagc tcaaaacgct tagcctagcc      960

acacccccac gggaaacagc agtgattaac ctttagcaat aaacgaaagt ttaactaagc     1020

tatactaacc ccagggttgg tcaatttcgt gccagccaca ccgagacctg gtccagagtc     1080

gctagccgcg tcgctaaaaa aaaaaaaaaa aaaaaaaaaa aaaaagcata tgactaaaaa     1140

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaa                                                                 1205


