                         SEQUENCE LISTING

<110>  The University of South Australia
       Central Adelaide Local Health Network Inc
       University of Adelaide
 
<120>  METHODS, PRODUCTS AND SYSTEMS FOR PROGNOSIS OF SUBJECTS SUFFERING
        FROM MULTIPLE MYELOMA

<130>  IRN1216533

<150>  AU2020904209
<151>  2020-11-18

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1117
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Arg Thr Arg Asp Arg Val Arg Leu Leu Leu Leu Leu Ile Cys 
1               5                   10                  15      


Phe Asn Val Gly Ser Gly Leu His Leu Gln Val Leu Ser Thr Arg Asn 
            20                  25                  30          


Glu Asn Lys Leu Leu Pro Lys His Pro His Leu Val Arg Gln Lys Arg 
        35                  40                  45              


Ala Trp Ile Thr Ala Pro Val Ala Leu Arg Glu Gly Glu Asp Leu Ser 
    50                  55                  60                  


Lys Lys Asn Pro Ile Ala Lys Ile His Ser Asp Leu Ala Glu Glu Arg 
65                  70                  75                  80  


Gly Leu Lys Ile Thr Tyr Lys Tyr Thr Gly Lys Gly Ile Thr Glu Pro 
                85                  90                  95      


Pro Phe Gly Ile Phe Val Phe Asn Lys Asp Thr Gly Glu Leu Asn Val 
            100                 105                 110         


Thr Ser Ile Leu Asp Arg Glu Glu Thr Pro Phe Phe Leu Leu Thr Gly 
        115                 120                 125             


Tyr Ala Leu Asp Ala Arg Gly Asn Asn Val Glu Lys Pro Leu Glu Leu 
    130                 135                 140                 


Arg Ile Lys Val Leu Asp Ile Asn Asp Asn Glu Pro Val Phe Thr Gln 
145                 150                 155                 160 


Asp Val Phe Val Gly Ser Val Glu Glu Leu Ser Ala Ala His Thr Leu 
                165                 170                 175     


Val Met Lys Ile Asn Ala Thr Asp Ala Asp Glu Pro Asn Thr Leu Asn 
            180                 185                 190         


Ser Lys Ile Ser Tyr Arg Ile Val Ser Leu Glu Pro Ala Tyr Pro Pro 
        195                 200                 205             


Val Phe Tyr Leu Asn Lys Asp Thr Gly Glu Ile Tyr Thr Thr Ser Val 
    210                 215                 220                 


Thr Leu Asp Arg Glu Glu His Ser Ser Tyr Thr Leu Thr Val Glu Ala 
225                 230                 235                 240 


Arg Asp Gly Asn Gly Glu Val Thr Asp Lys Pro Val Lys Gln Ala Gln 
                245                 250                 255     


Val Gln Ile Arg Ile Leu Asp Val Asn Asp Asn Ile Pro Val Val Glu 
            260                 265                 270         


Asn Lys Val Leu Glu Gly Met Val Glu Glu Asn Gln Val Asn Val Glu 
        275                 280                 285             


Val Thr Arg Ile Lys Val Phe Asp Ala Asp Glu Ile Gly Ser Asp Asn 
    290                 295                 300                 


Trp Leu Ala Asn Phe Thr Phe Ala Ser Gly Asn Glu Gly Gly Tyr Phe 
305                 310                 315                 320 


His Ile Glu Thr Asp Ala Gln Thr Asn Glu Gly Ile Val Thr Leu Ile 
                325                 330                 335     


Lys Glu Val Asp Tyr Glu Glu Met Lys Asn Leu Asp Phe Ser Val Ile 
            340                 345                 350         


Val Ala Asn Lys Ala Ala Phe His Lys Ser Ile Arg Ser Lys Tyr Lys 
        355                 360                 365             


Pro Thr Pro Ile Pro Ile Lys Val Lys Val Lys Asn Val Lys Glu Gly 
    370                 375                 380                 


Ile His Phe Lys Ser Ser Val Ile Ser Ile Tyr Val Ser Glu Ser Met 
385                 390                 395                 400 


Asp Arg Ser Ser Lys Gly Gln Ile Ile Gly Asn Phe Gln Ala Phe Asp 
                405                 410                 415     


Glu Asp Thr Gly Leu Pro Ala His Ala Arg Tyr Val Lys Leu Glu Asp 
            420                 425                 430         


Arg Asp Asn Trp Ile Ser Val Asp Ser Val Thr Ser Glu Ile Lys Leu 
        435                 440                 445             


Ala Lys Leu Pro Asp Phe Glu Ser Arg Tyr Val Gln Asn Gly Thr Tyr 
    450                 455                 460                 


Thr Val Lys Ile Val Ala Ile Ser Glu Asp Tyr Pro Arg Lys Thr Ile 
465                 470                 475                 480 


Thr Gly Thr Val Leu Ile Asn Val Glu Asp Ile Asn Asp Asn Cys Pro 
                485                 490                 495     


Thr Leu Ile Glu Pro Val Gln Thr Ile Cys His Asp Ala Glu Tyr Val 
            500                 505                 510         


Asn Val Thr Ala Glu Asp Leu Asp Gly His Pro Asn Ser Gly Pro Phe 
        515                 520                 525             


Ser Phe Ser Val Ile Asp Lys Pro Pro Gly Met Ala Glu Lys Trp Lys 
    530                 535                 540                 


Ile Ala Arg Gln Glu Ser Thr Ser Val Leu Leu Gln Gln Ser Glu Lys 
545                 550                 555                 560 


Lys Leu Gly Arg Ser Glu Ile Gln Phe Leu Ile Ser Asp Asn Gln Gly 
                565                 570                 575     


Phe Ser Cys Pro Glu Lys Gln Val Leu Thr Leu Thr Val Cys Glu Val 
            580                 585                 590         


Leu His Gly Ser Gly Cys Arg Glu Ala Gln His Asp Ser Tyr Val Gly 
        595                 600                 605             


Leu Gly Pro Ala Ala Ile Ala Leu Met Ile Leu Ala Phe Leu Leu Leu 
    610                 615                 620                 


Leu Leu Val Pro Leu Leu Leu Leu Met Cys His Cys Gly Lys Gly Ala 
625                 630                 635                 640 


Lys Ala Phe Thr Pro Ile Pro Gly Thr Ile Glu Met Leu His Pro Trp 
                645                 650                 655     


Asn Asn Glu Gly Ala Pro Pro Glu Asp Lys Val Val Pro Ser Phe Leu 
            660                 665                 670         


Pro Val Asp Gln Gly Gly Ser Leu Val Gly Arg Asn Gly Val Gly Gly 
        675                 680                 685             


Met Ala Lys Glu Ala Thr Met Lys Gly Ser Ser Ser Ala Ser Ile Val 
    690                 695                 700                 


Lys Gly Gln His Glu Met Ser Glu Met Asp Gly Arg Trp Glu Glu His 
705                 710                 715                 720 


Arg Ser Leu Leu Ser Gly Arg Ala Thr Gln Phe Thr Gly Ala Thr Gly 
                725                 730                 735     


Ala Ile Met Thr Thr Glu Thr Thr Lys Thr Ala Arg Ala Thr Gly Ala 
            740                 745                 750         


Ser Arg Asp Met Ala Gly Ala Gln Ala Ala Ala Val Ala Leu Asn Glu 
        755                 760                 765             


Glu Phe Leu Arg Asn Tyr Phe Thr Asp Lys Ala Ala Ser Tyr Thr Glu 
    770                 775                 780                 


Glu Asp Glu Asn His Thr Ala Lys Asp Cys Leu Leu Val Tyr Ser Gln 
785                 790                 795                 800 


Glu Glu Thr Glu Ser Leu Asn Ala Ser Ile Gly Cys Cys Ser Phe Ile 
                805                 810                 815     


Glu Gly Glu Leu Asp Asp Arg Phe Leu Asp Asp Leu Gly Leu Lys Phe 
            820                 825                 830         


Lys Thr Leu Ala Glu Val Cys Leu Gly Gln Lys Ile Asp Ile Asn Lys 
        835                 840                 845             


Glu Ile Glu Gln Arg Gln Lys Pro Ala Thr Glu Thr Ser Met Asn Thr 
    850                 855                 860                 


Ala Ser His Ser Leu Cys Glu Gln Thr Met Val Asn Ser Glu Asn Thr 
865                 870                 875                 880 


Tyr Ser Ser Gly Ser Ser Phe Pro Val Pro Lys Ser Leu Gln Glu Ala 
                885                 890                 895     


Asn Ala Glu Lys Val Thr Gln Glu Ile Val Thr Glu Arg Ser Val Ser 
            900                 905                 910         


Ser Arg Gln Ala Gln Lys Val Ala Thr Pro Leu Pro Asp Pro Met Ala 
        915                 920                 925             


Ser Arg Asn Val Ile Ala Thr Glu Thr Ser Tyr Val Thr Gly Ser Thr 
    930                 935                 940                 


Met Pro Pro Thr Thr Val Ile Leu Gly Pro Ser Gln Pro Gln Ser Leu 
945                 950                 955                 960 


Ile Val Thr Glu Arg Val Tyr Ala Pro Ala Ser Thr Leu Val Asp Gln 
                965                 970                 975     


Pro Tyr Ala Asn Glu Gly Thr Val Val Val Thr Glu Arg Val Ile Gln 
            980                 985                 990         


Pro His Gly Gly Gly Ser Asn Pro  Leu Glu Gly Thr Gln  His Leu Gln 
        995                 1000                 1005             


Asp Val  Pro Tyr Val Met Val  Arg Glu Arg Glu Ser  Phe Leu Ala 
    1010                 1015                 1020             


Pro Ser  Ser Gly Val Gln Pro  Thr Leu Ala Met Pro  Asn Ile Ala 
    1025                 1030                 1035             


Val Gly  Gln Asn Val Thr Val  Thr Glu Arg Val Leu  Ala Pro Ala 
    1040                 1045                 1050             


Ser Thr  Leu Gln Ser Ser Tyr  Gln Ile Pro Thr Glu  Asn Ser Met 
    1055                 1060                 1065             


Thr Ala  Arg Asn Thr Thr Val  Ser Gly Ala Gly Val  Pro Gly Pro 
    1070                 1075                 1080             


Leu Pro  Asp Phe Gly Leu Glu  Glu Ser Gly His Ser  Asn Ser Thr 
    1085                 1090                 1095             


Ile Thr  Thr Ser Ser Thr Arg  Val Thr Lys His Ser  Thr Val Gln 
    1100                 1105                 1110             


His Ser  Tyr Ser 
    1115         


<210>  2
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DSG2-shRNA60

<400>  2
tggatgtcaa tgacaatat                                                    19


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DSG2-shRNA62

<400>  3
ccagtgttct acctaaata                                                    19


<210>  4
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  non-silencing shRNA

<400>  4
atctcgcttg ggcgagagta ag                                                22


