                         SEQUENCE LISTING

<110>  Vanderbilt University
 
<120>  COMPOSITIONS AND METHODS FOR TARGETING THE INTERACTION OF HOST 
       MYO5B+D AND CORONAVIRUS M PROTEINS

<130>  222230-2030

<150>  US 63/109,941
<151>  2020-11-05

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Met Ser Ser Thr Thr Gln Ala Pro Glu Pro Val Tyr Gln Trp Thr Ala 
1               5                   10                  15      


Asp Glu Ala Val Gln Phe Leu Lys Glu Trp Asn Phe Ser Leu Gly Ile 
            20                  25                  30          


Ile Leu Leu Phe Ile Thr Ile Ile Leu Gln Phe Gly Tyr Thr Ser Arg 
        35                  40                  45              


Ser Met Phe Ile Tyr Val Val Lys Met Ile Ile Leu Trp Leu Met Trp 
    50                  55                  60                  


Pro Leu Thr Ile Val Leu Cys Ile Phe Asn Cys Val Tyr Ala Leu Asn 
65                  70                  75                  80  


Asn Val Tyr Leu Gly Phe Ser Ile Val Phe Thr Ile Val Ser Ile Val 
                85                  90                  95      


Ile Trp Ile Met Tyr Phe Val Asn Ser Ile Arg Leu Phe Ile Arg Thr 
            100                 105                 110         


Gly Ser Trp Trp Ser Phe Asn Pro Glu Thr Asn Asn Leu Met Cys Ile 
        115                 120                 125             


Asp Met Lys Gly Thr Val Tyr Val Arg Pro Ile Ile Glu Asp Tyr His 
    130                 135                 140                 


Thr Leu Thr Ala Thr Ile Ile Arg Gly His Leu Tyr Met Gln Gly Val 
145                 150                 155                 160 


Lys Leu Gly Thr Gly Phe Ser Leu Ser Asp Leu Pro Ala Tyr Val Thr 
                165                 170                 175     


Val Ala Lys Val Ser His Leu Cys Thr Tyr Lys Arg Ala Phe Leu Asp 
            180                 185                 190         


Lys Val Asp Gly Val Ser Gly Phe Ala Val Tyr Val Lys Ser Lys Val 
        195                 200                 205             


Gly Asn Tyr Arg Leu Pro Ser Asn Lys Pro Ser Gly Ala Asp Thr Ala 
    210                 215                 220                 


Leu Leu Arg Ile 
225             


<210>  2
<211>  104
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Ser Ile Arg Leu Phe Ile Arg Thr Gly Ser Trp Trp Ser Phe Asn Pro 
1               5                   10                  15      


Glu Thr Asn Asn Leu Met Cys Ile Asp Met Lys Gly Thr Val Tyr Val 
            20                  25                  30          


Arg Pro Ile Ile Glu Asp Tyr His Thr Leu Thr Ala Thr Ile Ile Arg 
        35                  40                  45              


Gly His Leu Tyr Met Gln Gly Val Lys Leu Gly Thr Gly Phe Ser Leu 
    50                  55                  60                  


Ser Asp Leu Pro Ala Tyr Val Thr Val Ala Lys Val Ser His Leu Cys 
65                  70                  75                  80  


Thr Tyr Lys Arg Ala Phe Leu Asp Lys Val Asp Gly Val Ser Gly Phe 
                85                  90                  95      


Ala Val Tyr Val Lys Ser Lys Val 
            100                 


<210>  3
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Met Ser Asn Met Thr Gln Leu Thr Glu Ala Gln Ile Ile Ala Ile Ile 
1               5                   10                  15      


Lys Asp Trp Asn Phe Ala Trp Ser Leu Ile Phe Leu Leu Ile Thr Ile 
            20                  25                  30          


Val Leu Gln Tyr Gly Tyr Pro Ser Arg Ser Met Thr Val Tyr Val Phe 
        35                  40                  45              


Lys Met Phe Val Leu Trp Leu Leu Trp Pro Ser Ser Met Ala Leu Ser 
    50                  55                  60                  


Ile Phe Ser Ala Val Tyr Pro Ile Asp Leu Ala Ser Gln Ile Ile Ser 
65                  70                  75                  80  


Gly Thr Val Ala Ala Val Ser Ala Met Met Trp Ile Ser Tyr Phe Val 
                85                  90                  95      


Gln Ser Ile Arg Leu Phe Met Arg Thr Gly Ser Trp Trp Ser Phe Asn 
            100                 105                 110         


Pro Glu Thr Asn Cys Leu Leu Asn Val Pro Phe Gly Gly Thr Thr Val 
        115                 120                 125             


Val Arg Pro Leu Val Glu Asp Ser Thr Ser Val Thr Ala Val Val Thr 
    130                 135                 140                 


Asn Gly His Leu Lys Met Ala Gly Met His Phe Gly Ala Cys Asp Tyr 
145                 150                 155                 160 


Asp Arg Leu Pro Asn Glu Val Thr Val Ala Lys Pro Asn Val Leu Ile 
                165                 170                 175     


Ala Leu Lys Met Val Lys Arg Gln Ser Tyr Gly Thr Asn Ser Gly Val 
            180                 185                 190         


Ala Ile Tyr His Arg Tyr Lys Ala Gly Asn Tyr Arg Ser Pro Pro Ile 
        195                 200                 205             


Thr Ala Asp Ile Glu Leu Ala Leu Leu Arg Ala 
    210                 215                 


<210>  4
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Ser Ile Arg Leu Phe Met Arg Thr Gly Ser Trp Trp Ser Phe Asn Pro 
1               5                   10                  15      


Glu Thr Asn Cys Leu Leu Asn Val Pro Phe Gly Gly Thr Thr Val Val 
            20                  25                  30          


Arg Pro Leu Val Glu Asp Ser Thr Ser Val Thr Ala Val Val Thr Asn 
        35                  40                  45              


Gly His Leu Lys Met Ala Gly Met His Phe Gly Ala Cys Asp Tyr Asp 
    50                  55                  60                  


Arg Leu Pro Asn Glu Val Thr Val Ala Lys Pro Asn Val Leu Ile Ala 
65                  70                  75                  80  


Leu Lys Met Val Lys Arg Gln Ser Tyr Gly Thr Asn Ser Gly Val Ala 
                85                  90                  95      


Ile Tyr His Arg Tyr Lys Ala Gly Asn Tyr Arg Ser Pro Pro Ile Thr 
            100                 105                 110         


Ala Asp Ile Glu Leu Ala Leu Leu Arg Ala 
        115                 120         


<210>  5
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Met Ala Glu Asn Asp Thr Ile Thr Val Asp Gln Leu Lys His Leu Leu 
1               5                   10                  15      


Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Phe Ala Trp Ile Leu 
            20                  25                  30          


Leu Leu Gln Phe Ala Tyr Ser Asn Arg Asn Arg Phe Leu Tyr Ile Ile 
        35                  40                  45              


Lys Leu Val Phe Leu Trp Leu Leu Trp Pro Ile Thr Leu Ala Cys Phe 
    50                  55                  60                  


Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Ala Thr Gly Gly Ile Ala 
65                  70                  75                  80  


Ile Ala Met Ala Cys Leu Val Gly Leu Met Trp Leu Ser Tyr Phe Val 
                85                  90                  95      


Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Trp Trp Ser Phe Asn 
            100                 105                 110         


Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu Arg Gly Ser Ile Ile 
        115                 120                 125             


Thr Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile Ile 
    130                 135                 140                 


Arg Gly Tyr Leu Arg Met Ala Gly His Ser Leu Gly Arg Cys Asp Ile 
145                 150                 155                 160 


Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser 
                165                 170                 175     


Tyr Tyr Arg Leu Gly Ala Ser Gln Arg Val Gly Thr Asp Ser Gly Phe 
            180                 185                 190         


Ala Val Tyr His Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp 
        195                 200                 205             


His Ser Gly Ser Asn Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220     


<210>  6
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Trp Trp Ser Phe Asn Pro 
1               5                   10                  15      


Glu Thr Asn Ile Leu Leu Asn Val Pro Leu Arg Gly Ser Ile Ile Thr 
            20                  25                  30          


Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile Ile Arg 
        35                  40                  45              


Gly Tyr Leu Arg Met Ala Gly His Ser Leu Gly Arg Cys Asp Ile Lys 
    50                  55                  60                  


Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr 
65                  70                  75                  80  


Tyr Arg Leu Gly Ala Ser Gln Arg Val Gly Thr Asp Ser Gly Phe Ala 
                85                  90                  95      


Val Tyr His Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp His 
            100                 105                 110         


Ser Gly Ser Asn Asp Asn Ile Ala Leu Leu Val Gln 
        115                 120                 


<210>  7
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Thr Trp Ile 
            20                  25                  30          


Cys Leu Leu Gln Phe Ala Tyr Ala Asn Arg Asn Arg Phe Leu Tyr Ile 
        35                  40                  45              


Ile Lys Leu Ile Phe Leu Trp Leu Val Trp Pro Val Thr Leu Ala Cys 
    50                  55                  60                  


Phe Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Ile Thr Gly Gly Ile 
65                  70                  75                  80  


Ala Ile Ala Met Ala Cys Leu Val Arg Leu Met Trp Leu Ser Tyr Phe 
                85                  90                  95      


Ile Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe 
            100                 105                 110         


Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile 
        115                 120                 125             


Leu Thr Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile 
    130                 135                 140                 


Leu Arg Gly His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp 
145                 150                 155                 160 


Ile Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu 
                165                 170                 175     


Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly 
            180                 185                 190         


Phe Ala Ala Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr 
        195                 200                 205             


Asp His Ser Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220         


<210>  8
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe Asn Pro Glu 
1               5                   10                  15      


Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile Leu Thr Arg 
            20                  25                  30          


Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile Leu Arg Gly 
        35                  40                  45              


His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp Ile Lys Asp 
    50                  55                  60                  


Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu Ser Tyr Tyr 
65                  70                  75                  80  


Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly Phe Ala Ala 
                85                  90                  95      


Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr Asp His Ser 
            100                 105                 110         


Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln 
        115                 120             


<210>  9
<211>  1848
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Met Ser Val Gly Glu Leu Tyr Ser Gln Cys Thr Arg Val Trp Ile Pro 
1               5                   10                  15      


Asp Pro Asp Glu Val Trp Arg Ser Ala Glu Leu Thr Lys Asp Tyr Lys 
            20                  25                  30          


Glu Gly Asp Lys Ser Leu Gln Leu Arg Leu Glu Asp Glu Thr Ile Leu 
        35                  40                  45              


Glu Tyr Pro Ile Asp Val Gln Arg Asn Gln Leu Pro Phe Leu Arg Asn 
    50                  55                  60                  


Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu 
65                  70                  75                  80  


His Glu Pro Ala Val Leu His Asn Leu Lys Val Arg Phe Leu Glu Ser 
                85                  90                  95      


Asn His Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro 
            100                 105                 110         


Tyr Glu Gln Leu Pro Ile Tyr Gly Gln Asp Val Ile Tyr Thr Tyr Ser 
        115                 120                 125             


Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu 
    130                 135                 140                 


Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Lys Asn Gln Ser Ile Ile 
145                 150                 155                 160 


Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala 
                165                 170                 175     


Met Arg Tyr Phe Ala Thr Val Gly Gly Ser Ala Ser Glu Thr Asn Ile 
            180                 185                 190         


Glu Glu Lys Val Leu Ala Ser Ser Pro Ile Met Glu Ala Ile Gly Asn 
        195                 200                 205             


Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile 
    210                 215                 220                 


Gln Ile Gly Phe Asp Lys Arg Tyr His Ile Ile Gly Ala Asn Met Arg 
225                 230                 235                 240 


Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Asp Asp Glu 
                245                 250                 255     


Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ala Ala Gly Leu Pro 
            260                 265                 270         


Glu Phe Lys Glu Leu Ala Leu Thr Ser Ala Glu Asp Phe Phe Tyr Thr 
        275                 280                 285             


Ser Gln Gly Gly Asp Thr Ser Ile Glu Gly Val Asp Asp Ala Glu Asp 
    290                 295                 300                 


Phe Glu Lys Thr Arg Gln Ala Phe Thr Leu Leu Gly Val Lys Glu Ser 
305                 310                 315                 320 


His Gln Met Ser Ile Phe Lys Ile Ile Ala Ser Ile Leu His Leu Gly 
                325                 330                 335     


Ser Val Ala Ile Gln Ala Glu Arg Asp Gly Asp Ser Cys Ser Ile Ser 
            340                 345                 350         


Pro Gln Asp Val Tyr Leu Ser Asn Phe Cys Arg Leu Leu Gly Val Glu 
        355                 360                 365             


His Ser Gln Met Glu His Trp Leu Cys His Arg Lys Leu Val Thr Thr 
    370                 375                 380                 


Ser Glu Thr Tyr Val Lys Thr Met Ser Leu Gln Gln Val Ile Asn Ala 
385                 390                 395                 400 


Arg Asn Ala Leu Ala Lys His Ile Tyr Ala Gln Leu Phe Gly Trp Ile 
                405                 410                 415     


Val Glu His Ile Asn Lys Ala Leu His Thr Ser Leu Lys Gln His Ser 
            420                 425                 430         


Phe Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Val Asn 
        435                 440                 445             


Ser Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln 
    450                 455                 460                 


Gln Phe Asn Ser His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys 
465                 470                 475                 480 


Glu Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys 
                485                 490                 495     


Ile Asp Leu Ile Glu Ala Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu 
            500                 505                 510         


Glu Cys Lys Val Pro Lys Gly Thr Asp Gln Asn Trp Ala Gln Lys Leu 
        515                 520                 525             


Tyr Asp Arg His Ser Ser Ser Gln His Phe Gln Lys Pro Arg Met Ser 
    530                 535                 540                 


Asn Thr Ala Phe Ile Ile Val His Phe Ala Asp Lys Val Glu Tyr Leu 
545                 550                 555                 560 


Ser Asp Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Glu Glu Gln 
                565                 570                 575     


Ile Asn Ile Leu Lys Ala Ser Lys Phe Pro Leu Val Ala Asp Leu Phe 
            580                 585                 590         


His Asp Asp Lys Asp Pro Val Pro Ala Thr Thr Pro Gly Lys Gly Ser 
        595                 600                 605             


Ser Ser Lys Ile Ser Val Arg Ser Ala Arg Pro Pro Met Lys Val Ser 
    610                 615                 620                 


Asn Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg Thr Ser Leu 
625                 630                 635                 640 


His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His Tyr Val Arg 
                645                 650                 655     


Cys Ile Lys Pro Asn Asp Glu Lys Leu Pro Phe His Phe Asp Pro Lys 
            660                 665                 670         


Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu Thr Ile Arg 
        675                 680                 685             


Ile Ser Ala Ala Gly Tyr Pro Ser Arg Trp Ala Tyr His Asp Phe Phe 
    690                 695                 700                 


Asn Arg Tyr Arg Val Leu Val Lys Lys Arg Glu Leu Ala Asn Thr Asp 
705                 710                 715                 720 


Lys Lys Ala Ile Cys Arg Ser Val Leu Glu Asn Leu Ile Lys Asp Pro 
                725                 730                 735     


Asp Lys Phe Gln Phe Gly Arg Thr Lys Ile Phe Phe Arg Ala Gly Gln 
            740                 745                 750         


Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Phe Arg Thr Ala Thr 
        755                 760                 765             


Ile Met Ile Gln Lys Thr Val Arg Gly Trp Leu Gln Lys Val Lys Tyr 
    770                 775                 780                 


His Arg Leu Lys Gly Ala Thr Leu Thr Leu Gln Arg Tyr Cys Arg Gly 
785                 790                 795                 800 


His Leu Ala Arg Arg Leu Ala Glu His Leu Arg Arg Ile Arg Ala Ala 
                805                 810                 815     


Val Val Leu Gln Lys His Tyr Arg Met Gln Arg Ala Arg Gln Ala Tyr 
            820                 825                 830         


Gln Arg Val Arg Arg Ala Ala Val Val Ile Gln Ala Phe Thr Arg Ala 
        835                 840                 845             


Met Phe Val Arg Arg Thr Tyr Arg Gln Val Leu Met Glu His Lys Ala 
    850                 855                 860                 


Thr Thr Ile Gln Lys His Val Arg Gly Trp Met Ala Arg Arg His Phe 
865                 870                 875                 880 


Gln Arg Leu Arg Asp Ala Ala Ile Val Ile Gln Cys Ala Phe Arg Met 
                885                 890                 895     


Leu Lys Ala Arg Arg Glu Leu Lys Ala Leu Arg Ile Glu Ala Arg Ser 
            900                 905                 910         


Ala Glu His Leu Lys Arg Leu Asn Val Gly Met Glu Asn Lys Val Val 
        915                 920                 925             


Gln Leu Gln Arg Lys Ile Asp Glu Gln Asn Lys Glu Phe Lys Thr Leu 
    930                 935                 940                 


Ser Glu Gln Leu Ser Val Thr Thr Ser Thr Tyr Thr Met Glu Val Glu 
945                 950                 955                 960 


Arg Leu Lys Lys Glu Leu Val His Tyr Gln Gln Ser Pro Gly Glu Asp 
                965                 970                 975     


Thr Ser Leu Arg Leu Gln Glu Glu Val Glu Ser Leu Arg Thr Glu Leu 
            980                 985                 990         


Gln Arg Ala His Ser Glu Arg Lys  Ile Leu Glu Asp Ala  His Ser Arg 
        995                 1000                 1005             


Glu Lys  Asp Glu Leu Arg Lys  Arg Val Ala Asp Leu  Glu Gln Glu 
    1010                 1015                 1020             


Asn Ala  Leu Leu Lys Asp Glu  Lys Glu Gln Leu Asn  Asn Gln Ile 
    1025                 1030                 1035             


Leu Cys  Gln Ser Lys Asp Glu  Phe Ala Gln Asn Ser  Val Lys Glu 
    1040                 1045                 1050             


Asn Leu  Met Lys Lys Glu Leu  Glu Glu Glu Arg Ser  Arg Tyr Gln 
    1055                 1060                 1065             


Asn Leu  Val Lys Glu Tyr Ser  Gln Leu Glu Gln Arg  Tyr Asp Asn 
    1070                 1075                 1080             


Leu Arg  Asp Glu Met Thr Ile  Ile Lys Gln Thr Pro  Gly His Arg 
    1085                 1090                 1095             


Arg Asn  Pro Ser Asn Gln Ser  Ser Leu Glu Ser Asp  Ser Asn Tyr 
    1100                 1105                 1110             


Pro Ser  Ile Ser Thr Ser Glu  Ile Gly Asp Thr Glu  Asp Ala Leu 
    1115                 1120                 1125             


Gln Gln  Val Glu Glu Ile Gly  Leu Glu Lys Ala Ala  Met Asp Met 
    1130                 1135                 1140             


Thr Val  Phe Leu Lys Leu Gln  Lys Arg Val Arg Glu  Leu Glu Gln 
    1145                 1150                 1155             


Glu Arg  Lys Lys Leu Gln Val  Gln Leu Glu Lys Arg  Glu Gln Gln 
    1160                 1165                 1170             


Asp Ser  Lys Lys Val Gln Ala  Glu Pro Pro Gln Thr  Asp Ile Asp 
    1175                 1180                 1185             


Leu Asp  Pro Asn Ala Asp Leu  Ala Tyr Asn Ser Leu  Lys Arg Gln 
    1190                 1195                 1200             


Glu Leu  Glu Ser Glu Asn Lys  Lys Leu Lys Asn Asp  Leu Asn Glu 
    1205                 1210                 1215             


Leu Arg  Lys Ala Val Ala Asp  Gln Ala Thr Gln Asn  Asn Ser Ser 
    1220                 1225                 1230             


His Gly  Ser Pro Asp Ser Tyr  Ser Leu Leu Leu Asn  Gln Leu Lys 
    1235                 1240                 1245             


Leu Ala  His Glu Glu Leu Glu  Val Arg Lys Glu Glu  Val Leu Ile 
    1250                 1255                 1260             


Leu Arg  Thr Gln Ile Val Ser  Ala Asp Gln Arg Arg  Leu Ala Gly 
    1265                 1270                 1275             


Arg Asn  Ala Glu Pro Asn Ile  Asn Ala Arg Ser Ser  Trp Pro Asn 
    1280                 1285                 1290             


Ser Glu  Lys His Val Asp Gln  Glu Asp Ala Ile Glu  Ala Tyr His 
    1295                 1300                 1305             


Gly Val  Cys Gln Thr Asn Ser  Lys Thr Glu Asp Trp  Gly Tyr Leu 
    1310                 1315                 1320             


Asn Glu  Asp Gly Glu Leu Gly  Leu Ala Tyr Gln Gly  Leu Lys Gln 
    1325                 1330                 1335             


Val Ala  Arg Leu Leu Glu Ala  Gln Leu Gln Ala Gln  Ser Leu Glu 
    1340                 1345                 1350             


His Glu  Glu Glu Val Glu His  Leu Lys Ala Gln Leu  Glu Ala Leu 
    1355                 1360                 1365             


Lys Glu  Glu Met Asp Lys Gln  Gln Gln Thr Phe Cys  Gln Thr Leu 
    1370                 1375                 1380             


Leu Leu  Ser Pro Glu Ala Gln  Val Glu Phe Gly Val  Gln Gln Glu 
    1385                 1390                 1395             


Ile Ser  Arg Leu Thr Asn Glu  Asn Leu Asp Leu Lys  Glu Leu Val 
    1400                 1405                 1410             


Glu Lys  Leu Glu Lys Asn Glu  Arg Lys Leu Lys Lys  Gln Leu Lys 
    1415                 1420                 1425             


Ile Tyr  Met Lys Lys Ala Gln  Asp Leu Glu Ala Ala  Gln Ala Leu 
    1430                 1435                 1440             


Ala Gln  Ser Glu Arg Lys Arg  His Glu Leu Asn Arg  Gln Val Thr 
    1445                 1450                 1455             


Val Gln  Arg Lys Glu Lys Asp  Phe Gln Gly Met Leu  Glu Tyr His 
    1460                 1465                 1470             


Lys Glu  Asp Glu Ala Leu Leu  Ile Arg Asn Leu Val  Thr Asp Leu 
    1475                 1480                 1485             


Lys Pro  Gln Met Leu Ser Gly  Thr Val Pro Cys Leu  Pro Ala Tyr 
    1490                 1495                 1500             


Ile Leu  Tyr Met Cys Ile Arg  His Ala Asp Tyr Thr  Asn Asp Asp 
    1505                 1510                 1515             


Leu Lys  Val His Ser Leu Leu  Thr Ser Thr Ile Asn  Gly Ile Lys 
    1520                 1525                 1530             


Lys Val  Leu Lys Lys His Asn  Asp Asp Phe Glu Met  Thr Ser Phe 
    1535                 1540                 1545             


Trp Leu  Ser Asn Thr Cys Arg  Leu Leu His Cys Leu  Lys Gln Tyr 
    1550                 1555                 1560             


Ser Gly  Asp Glu Gly Phe Met  Thr Gln Asn Thr Ala  Lys Gln Asn 
    1565                 1570                 1575             


Glu His  Cys Leu Lys Asn Phe  Asp Leu Thr Glu Tyr  Arg Gln Val 
    1580                 1585                 1590             


Leu Ser  Asp Leu Ser Ile Gln  Ile Tyr Gln Gln Leu  Ile Lys Ile 
    1595                 1600                 1605             


Ala Glu  Gly Val Leu Gln Pro  Met Ile Val Ser Ala  Met Leu Glu 
    1610                 1615                 1620             


Asn Glu  Ser Ile Gln Gly Leu  Ser Gly Val Lys Pro  Thr Gly Tyr 
    1625                 1630                 1635             


Arg Lys  Arg Ser Ser Ser Met  Ala Asp Gly Asp Asn  Ser Tyr Cys 
    1640                 1645                 1650             


Leu Glu  Ala Ile Ile Arg Gln  Met Asn Ala Phe His  Thr Val Met 
    1655                 1660                 1665             


Cys Asp  Gln Gly Leu Asp Pro  Glu Ile Ile Leu Gln  Val Phe Lys 
    1670                 1675                 1680             


Gln Leu  Phe Tyr Met Ile Asn  Ala Val Thr Leu Asn  Asn Leu Leu 
    1685                 1690                 1695             


Leu Arg  Lys Asp Val Cys Ser  Trp Ser Thr Gly Met  Gln Leu Arg 
    1700                 1705                 1710             


Tyr Asn  Ile Ser Gln Leu Glu  Glu Trp Leu Arg Gly  Arg Asn Leu 
    1715                 1720                 1725             


His Gln  Ser Gly Ala Val Gln  Thr Met Glu Pro Leu  Ile Gln Ala 
    1730                 1735                 1740             


Ala Gln  Leu Leu Gln Leu Lys  Lys Lys Thr Gln Glu  Asp Ala Glu 
    1745                 1750                 1755             


Ala Ile  Cys Ser Leu Cys Thr  Ser Leu Ser Thr Gln  Gln Ile Val 
    1760                 1765                 1770             


Lys Ile  Leu Asn Leu Tyr Thr  Pro Leu Asn Glu Phe  Glu Glu Arg 
    1775                 1780                 1785             


Val Thr  Val Ala Phe Ile Arg  Thr Ile Gln Ala Gln  Leu Gln Glu 
    1790                 1795                 1800             


Arg Asn  Asp Pro Gln Gln Leu  Leu Leu Asp Ala Lys  His Met Phe 
    1805                 1810                 1815             


Pro Val  Leu Phe Pro Phe Asn  Pro Ser Ser Leu Thr  Met Asp Ser 
    1820                 1825                 1830             


Ile His  Ile Pro Ala Cys Leu  Asn Leu Glu Phe Leu  Asn Glu Val 
    1835                 1840                 1845             


<210>  10
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Gly Ser Pro Asp Ser Tyr Ser Leu Leu Leu Asn Gln Leu Lys Leu Ala 
1               5                   10                  15      


His Glu Glu Leu Glu Val Arg Lys Glu Glu Val Leu Ile Leu Arg Thr 
            20                  25                  30          


Gln Ile Val Ser Ala Asp Gln Arg Arg Leu Ala Gly Arg Asn Ala Glu 
        35                  40                  45              


Pro Asn Ile Asn Ala Arg Ser Ser Trp Pro Asn Ser Glu Lys His Val 
    50                  55                  60                  


Asp Gln Glu Asp Ala Ile Glu Ala Tyr His Gly Val Cys Gln Thr Asn 
65                  70                  75                  80  


Ser Lys Thr Glu Asp Trp Gly Tyr Leu Asn Glu Asp Gly Glu Leu Gly 
                85                  90                  95      


Leu Ala Tyr Gln Gly Leu Lys Gln Val Ala Arg Leu Leu Glu Ala Gln 
            100                 105                 110         


Leu Gln Ala Gln Ser Leu Glu His Glu Glu Glu Val Glu His Leu Lys 
        115                 120                 125             


Ala Gln Leu Glu Ala Leu Lys Glu Glu Met Asp Lys Gln Gln Gln Thr 
    130                 135                 140                 


Phe Cys Gln Thr Leu Leu Leu Ser Pro Glu Ala Gln Val Glu Phe Gly 
145                 150                 155                 160 


Val Gln Gln Glu Ile Ser Arg Leu Thr Asn Glu Asn Leu Asp Leu Lys 
                165                 170                 175     


Glu Leu Val Glu Lys Leu Glu Lys Asn Glu Arg Lys Leu Lys Lys Gln 
            180                 185                 190         


Leu Lys Ile Tyr Met Lys Lys Ala Gln Asp Leu Glu Ala 
        195                 200                 205 


<210>  11
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Ser Lys Thr Glu Asp Trp Gly Tyr Leu Asn Glu Asp Gly Glu Leu Gly 
1               5                   10                  15      


Leu Ala Tyr Gln Gly Leu Lys Gln Val Ala 
            20                  25      


<210>  12
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
ggtggagctt caaccccaaa acaaacaacc taatg                                  35


<210>  13
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
aaacaaccta atgtgtacag atacgaaagg tactgtgtat gttagac                     47


<210>  14
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
ggtggtcttt caatcctaaa acagacgcgc ttctc                                  35


<210>  15
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
gatcatggtg gtcattcaat cctaagacta attgcctttt g                           41


<210>  16
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
tccatgtggt cattcaatcc aaaaactaac attcttctca acg                         43


