                         SEQUENCE LISTING

<110>  Translate Bio, Inc.
 
<120>  IMPROVED COMPOSITIONS FOR DELIVERY OF CODON-OPTIMIZED MRNA

<130>  MRT-2205USP1

<150>  63/111,321
<151>  2020-11-09

<150>  63/195,581
<151>  2021-06-01

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  1480
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Arg Ser Pro Leu Glu Lys Ala Ser Val Val Ser Lys Leu Phe 
1               5                   10                  15      


Phe Ser Trp Thr Arg Pro Ile Leu Arg Lys Gly Tyr Arg Gln Arg Leu 
            20                  25                  30          


Glu Leu Ser Asp Ile Tyr Gln Ile Pro Ser Val Asp Ser Ala Asp Asn 
        35                  40                  45              


Leu Ser Glu Lys Leu Glu Arg Glu Trp Asp Arg Glu Leu Ala Ser Lys 
    50                  55                  60                  


Lys Asn Pro Lys Leu Ile Asn Ala Leu Arg Arg Cys Phe Phe Trp Arg 
65                  70                  75                  80  


Phe Met Phe Tyr Gly Ile Phe Leu Tyr Leu Gly Glu Val Thr Lys Ala 
                85                  90                  95      


Val Gln Pro Leu Leu Leu Gly Arg Ile Ile Ala Ser Tyr Asp Pro Asp 
            100                 105                 110         


Asn Lys Glu Glu Arg Ser Ile Ala Ile Tyr Leu Gly Ile Gly Leu Cys 
        115                 120                 125             


Leu Leu Phe Ile Val Arg Thr Leu Leu Leu His Pro Ala Ile Phe Gly 
    130                 135                 140                 


Leu His His Ile Gly Met Gln Met Arg Ile Ala Met Phe Ser Leu Ile 
145                 150                 155                 160 


Tyr Lys Lys Thr Leu Lys Leu Ser Ser Arg Val Leu Asp Lys Ile Ser 
                165                 170                 175     


Ile Gly Gln Leu Val Ser Leu Leu Ser Asn Asn Leu Asn Lys Phe Asp 
            180                 185                 190         


Glu Gly Leu Ala Leu Ala His Phe Val Trp Ile Ala Pro Leu Gln Val 
        195                 200                 205             


Ala Leu Leu Met Gly Leu Ile Trp Glu Leu Leu Gln Ala Ser Ala Phe 
    210                 215                 220                 


Cys Gly Leu Gly Phe Leu Ile Val Leu Ala Leu Phe Gln Ala Gly Leu 
225                 230                 235                 240 


Gly Arg Met Met Met Lys Tyr Arg Asp Gln Arg Ala Gly Lys Ile Ser 
                245                 250                 255     


Glu Arg Leu Val Ile Thr Ser Glu Met Ile Glu Asn Ile Gln Ser Val 
            260                 265                 270         


Lys Ala Tyr Cys Trp Glu Glu Ala Met Glu Lys Met Ile Glu Asn Leu 
        275                 280                 285             


Arg Gln Thr Glu Leu Lys Leu Thr Arg Lys Ala Ala Tyr Val Arg Tyr 
    290                 295                 300                 


Phe Asn Ser Ser Ala Phe Phe Phe Ser Gly Phe Phe Val Val Phe Leu 
305                 310                 315                 320 


Ser Val Leu Pro Tyr Ala Leu Ile Lys Gly Ile Ile Leu Arg Lys Ile 
                325                 330                 335     


Phe Thr Thr Ile Ser Phe Cys Ile Val Leu Arg Met Ala Val Thr Arg 
            340                 345                 350         


Gln Phe Pro Trp Ala Val Gln Thr Trp Tyr Asp Ser Leu Gly Ala Ile 
        355                 360                 365             


Asn Lys Ile Gln Asp Phe Leu Gln Lys Gln Glu Tyr Lys Thr Leu Glu 
    370                 375                 380                 


Tyr Asn Leu Thr Thr Thr Glu Val Val Met Glu Asn Val Thr Ala Phe 
385                 390                 395                 400 


Trp Glu Glu Gly Phe Gly Glu Leu Phe Glu Lys Ala Lys Gln Asn Asn 
                405                 410                 415     


Asn Asn Arg Lys Thr Ser Asn Gly Asp Asp Ser Leu Phe Phe Ser Asn 
            420                 425                 430         


Phe Ser Leu Leu Gly Thr Pro Val Leu Lys Asp Ile Asn Phe Lys Ile 
        435                 440                 445             


Glu Arg Gly Gln Leu Leu Ala Val Ala Gly Ser Thr Gly Ala Gly Lys 
    450                 455                 460                 


Thr Ser Leu Leu Met Val Ile Met Gly Glu Leu Glu Pro Ser Glu Gly 
465                 470                 475                 480 


Lys Ile Lys His Ser Gly Arg Ile Ser Phe Cys Ser Gln Phe Ser Trp 
                485                 490                 495     


Ile Met Pro Gly Thr Ile Lys Glu Asn Ile Ile Phe Gly Val Ser Tyr 
            500                 505                 510         


Asp Glu Tyr Arg Tyr Arg Ser Val Ile Lys Ala Cys Gln Leu Glu Glu 
        515                 520                 525             


Asp Ile Ser Lys Phe Ala Glu Lys Asp Asn Ile Val Leu Gly Glu Gly 
    530                 535                 540                 


Gly Ile Thr Leu Ser Gly Gly Gln Arg Ala Arg Ile Ser Leu Ala Arg 
545                 550                 555                 560 


Ala Val Tyr Lys Asp Ala Asp Leu Tyr Leu Leu Asp Ser Pro Phe Gly 
                565                 570                 575     


Tyr Leu Asp Val Leu Thr Glu Lys Glu Ile Phe Glu Ser Cys Val Cys 
            580                 585                 590         


Lys Leu Met Ala Asn Lys Thr Arg Ile Leu Val Thr Ser Lys Met Glu 
        595                 600                 605             


His Leu Lys Lys Ala Asp Lys Ile Leu Ile Leu His Glu Gly Ser Ser 
    610                 615                 620                 


Tyr Phe Tyr Gly Thr Phe Ser Glu Leu Gln Asn Leu Gln Pro Asp Phe 
625                 630                 635                 640 


Ser Ser Lys Leu Met Gly Cys Asp Ser Phe Asp Gln Phe Ser Ala Glu 
                645                 650                 655     


Arg Arg Asn Ser Ile Leu Thr Glu Thr Leu His Arg Phe Ser Leu Glu 
            660                 665                 670         


Gly Asp Ala Pro Val Ser Trp Thr Glu Thr Lys Lys Gln Ser Phe Lys 
        675                 680                 685             


Gln Thr Gly Glu Phe Gly Glu Lys Arg Lys Asn Ser Ile Leu Asn Pro 
    690                 695                 700                 


Ile Asn Ser Ile Arg Lys Phe Ser Ile Val Gln Lys Thr Pro Leu Gln 
705                 710                 715                 720 


Met Asn Gly Ile Glu Glu Asp Ser Asp Glu Pro Leu Glu Arg Arg Leu 
                725                 730                 735     


Ser Leu Val Pro Asp Ser Glu Gln Gly Glu Ala Ile Leu Pro Arg Ile 
            740                 745                 750         


Ser Val Ile Ser Thr Gly Pro Thr Leu Gln Ala Arg Arg Arg Gln Ser 
        755                 760                 765             


Val Leu Asn Leu Met Thr His Ser Val Asn Gln Gly Gln Asn Ile His 
    770                 775                 780                 


Arg Lys Thr Thr Ala Ser Thr Arg Lys Val Ser Leu Ala Pro Gln Ala 
785                 790                 795                 800 


Asn Leu Thr Glu Leu Asp Ile Tyr Ser Arg Arg Leu Ser Gln Glu Thr 
                805                 810                 815     


Gly Leu Glu Ile Ser Glu Glu Ile Asn Glu Glu Asp Leu Lys Glu Cys 
            820                 825                 830         


Phe Phe Asp Asp Met Glu Ser Ile Pro Ala Val Thr Thr Trp Asn Thr 
        835                 840                 845             


Tyr Leu Arg Tyr Ile Thr Val His Lys Ser Leu Ile Phe Val Leu Ile 
    850                 855                 860                 


Trp Cys Leu Val Ile Phe Leu Ala Glu Val Ala Ala Ser Leu Val Val 
865                 870                 875                 880 


Leu Trp Leu Leu Gly Asn Thr Pro Leu Gln Asp Lys Gly Asn Ser Thr 
                885                 890                 895     


His Ser Arg Asn Asn Ser Tyr Ala Val Ile Ile Thr Ser Thr Ser Ser 
            900                 905                 910         


Tyr Tyr Val Phe Tyr Ile Tyr Val Gly Val Ala Asp Thr Leu Leu Ala 
        915                 920                 925             


Met Gly Phe Phe Arg Gly Leu Pro Leu Val His Thr Leu Ile Thr Val 
    930                 935                 940                 


Ser Lys Ile Leu His His Lys Met Leu His Ser Val Leu Gln Ala Pro 
945                 950                 955                 960 


Met Ser Thr Leu Asn Thr Leu Lys Ala Gly Gly Ile Leu Asn Arg Phe 
                965                 970                 975     


Ser Lys Asp Ile Ala Ile Leu Asp Asp Leu Leu Pro Leu Thr Ile Phe 
            980                 985                 990         


Asp Phe Ile Gln Leu Leu Leu Ile  Val Ile Gly Ala Ile  Ala Val Val 
        995                 1000                 1005             


Ala Val  Leu Gln Pro Tyr Ile  Phe Val Ala Thr Val  Pro Val Ile 
    1010                 1015                 1020             


Val Ala  Phe Ile Met Leu Arg  Ala Tyr Phe Leu Gln  Thr Ser Gln 
    1025                 1030                 1035             


Gln Leu  Lys Gln Leu Glu Ser  Glu Gly Arg Ser Pro  Ile Phe Thr 
    1040                 1045                 1050             


His Leu  Val Thr Ser Leu Lys  Gly Leu Trp Thr Leu  Arg Ala Phe 
    1055                 1060                 1065             


Gly Arg  Gln Pro Tyr Phe Glu  Thr Leu Phe His Lys  Ala Leu Asn 
    1070                 1075                 1080             


Leu His  Thr Ala Asn Trp Phe  Leu Tyr Leu Ser Thr  Leu Arg Trp 
    1085                 1090                 1095             


Phe Gln  Met Arg Ile Glu Met  Ile Phe Val Ile Phe  Phe Ile Ala 
    1100                 1105                 1110             


Val Thr  Phe Ile Ser Ile Leu  Thr Thr Gly Glu Gly  Glu Gly Arg 
    1115                 1120                 1125             


Val Gly  Ile Ile Leu Thr Leu  Ala Met Asn Ile Met  Ser Thr Leu 
    1130                 1135                 1140             


Gln Trp  Ala Val Asn Ser Ser  Ile Asp Val Asp Ser  Leu Met Arg 
    1145                 1150                 1155             


Ser Val  Ser Arg Val Phe Lys  Phe Ile Asp Met Pro  Thr Glu Gly 
    1160                 1165                 1170             


Lys Pro  Thr Lys Ser Thr Lys  Pro Tyr Lys Asn Gly  Gln Leu Ser 
    1175                 1180                 1185             


Lys Val  Met Ile Ile Glu Asn  Ser His Val Lys Lys  Asp Asp Ile 
    1190                 1195                 1200             


Trp Pro  Ser Gly Gly Gln Met  Thr Val Lys Asp Leu  Thr Ala Lys 
    1205                 1210                 1215             


Tyr Thr  Glu Gly Gly Asn Ala  Ile Leu Glu Asn Ile  Ser Phe Ser 
    1220                 1225                 1230             


Ile Ser  Pro Gly Gln Arg Val  Gly Leu Leu Gly Arg  Thr Gly Ser 
    1235                 1240                 1245             


Gly Lys  Ser Thr Leu Leu Ser  Ala Phe Leu Arg Leu  Leu Asn Thr 
    1250                 1255                 1260             


Glu Gly  Glu Ile Gln Ile Asp  Gly Val Ser Trp Asp  Ser Ile Thr 
    1265                 1270                 1275             


Leu Gln  Gln Trp Arg Lys Ala  Phe Gly Val Ile Pro  Gln Lys Val 
    1280                 1285                 1290             


Phe Ile  Phe Ser Gly Thr Phe  Arg Lys Asn Leu Asp  Pro Tyr Glu 
    1295                 1300                 1305             


Gln Trp  Ser Asp Gln Glu Ile  Trp Lys Val Ala Asp  Glu Val Gly 
    1310                 1315                 1320             


Leu Arg  Ser Val Ile Glu Gln  Phe Pro Gly Lys Leu  Asp Phe Val 
    1325                 1330                 1335             


Leu Val  Asp Gly Gly Cys Val  Leu Ser His Gly His  Lys Gln Leu 
    1340                 1345                 1350             


Met Cys  Leu Ala Arg Ser Val  Leu Ser Lys Ala Lys  Ile Leu Leu 
    1355                 1360                 1365             


Leu Asp  Glu Pro Ser Ala His  Leu Asp Pro Val Thr  Tyr Gln Ile 
    1370                 1375                 1380             


Ile Arg  Arg Thr Leu Lys Gln  Ala Phe Ala Asp Cys  Thr Val Ile 
    1385                 1390                 1395             


Leu Cys  Glu His Arg Ile Glu  Ala Met Leu Glu Cys  Gln Gln Phe 
    1400                 1405                 1410             


Leu Val  Ile Glu Glu Asn Lys  Val Arg Gln Tyr Asp  Ser Ile Gln 
    1415                 1420                 1425             


Lys Leu  Leu Asn Glu Arg Ser  Leu Phe Arg Gln Ala  Ile Ser Pro 
    1430                 1435                 1440             


Ser Asp  Arg Val Lys Leu Phe  Pro His Arg Asn Ser  Ser Lys Cys 
    1445                 1450                 1455             


Lys Ser  Lys Pro Gln Ile Ala  Ala Leu Lys Glu Glu  Thr Glu Glu 
    1460                 1465                 1470             


Glu Val  Gln Asp Thr Arg Leu  
    1475                 1480 


<210>  2
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  2
atgcagcgtt ctcccctgga gaaggcttct gtggtgagta aacttttttt ctcctggacc       60

agacctatcc tgaggaaagg ctacaggcag agactggagc tctctgacat ataccagata      120

ccttcagtcg atagcgccga caacctgagc gagaagctgg aacgcgagtg ggacagagag      180

ctggcaagca agaagaaccc aaagctgatt aatgccctga gaaggtgttt cttctggaga      240

ttcatgttct acggaatctt tctgtatctg ggggaggtta caaaggctgt gcaacccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaaca aggaagaaag aagcatcgcc      360

atctacctgg gcattggcct ctgcctcctg tttattgtgc ggactctgct gctgcaccca      420

gcaattttcg ggttgcatca tattggcatg cagatgcgca ttgctatgtt ttccctcatc      480

tacaaaaaga cactgaaact cagctcccgg gtgctggaca agatctccat cggccaactg      540

gtgtctctcc tgagcaataa cttgaataag ttcgacgaag ggctggccct ggcacacttc      600

gtgtggattg cccccctgca ggtggccctg ctgatgggac tgatttggga actgctgcag      660

gctagcgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg ggttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctgc ggaagatctt caccaccatc     1020

agcttttgca tcgtgcttag aatggccgtg acacggcagt tcccatgggc cgttcaaact     1080

tggtatgatt ccctgggcgc catcaacaaa atccaggatt tcctgcagaa gcaggaatac     1140

aagacactcg aatataacct cacaactact gaggtggtta tggagaacgt gactgccttc     1200

tgggaggagg ggttcggaga gctttttgag aaggccaaac agaataataa taaccgcaaa     1260

accagcaacg gcgacgacag cctgttcttc tccaattttt ctctcctggg aacacccgtc     1320

ctcaaagaca tcaactttaa gatcgagagg ggccagctgc tcgccgtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc ctccgagggc     1440

aagattaagc actcaggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaagttcg cagagaagga taatattgtg     1620

ctgggagagg gaggaatcac cctgagcgga ggccagagag ccagaatctc actggcccgg     1680

gccgtctaca aggacgccga cctttacctt ctggacagtc cctttggata tctggatgtg     1740

ctgactgaaa aggagatctt cgagtcttgt gtgtgcaagc tgatggctaa caagacccgg     1800

atcctagtga ctagtaagat ggagcacctg aagaaggcag acaagatctt gattctgcac     1860

gagggatcct cttactttta cggcaccttt agcgagctgc agaacctcca gcccgatttc     1920

tcatctaagc tgatgggctg tgatagcttc gaccagttct ctgccgagcg cagaaacagc     1980

atcctgacag agacactgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttc ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

agcacactgc agtgggccgt gaatagtagt atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagaaggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaagctcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  3
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  3
atgcagcgct cgcctctgga aaaggcgagc gtcgtgtcaa agctattctt ttcttggacc       60

cggcccattc tcaggaaggg ctacaggcag aggctggagt tgagcgacat ctatcagatt      120

ccttccgtgg acagcgccga caacctgagc gagaagctgg aaagggagtg ggaccgcgaa      180

ctggcaagca aaaagaaccc caagctgatc aatgccctga gaaggtgttt cttttggaga      240

ttcatgttct acgggatctt tctgtatctg ggcgaggtta caaaggctgt gcagcccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaaca aggaagaaag aagcatcgcc      360

atctacctgg gcattggcct ctgcctcctg tttattgtgc ggactctgct gctgcaccca      420

gcaattttcg ggttgcatca tattggcatg cagatgcgca ttgctatgtt ttccctcatc      480

tacaaaaaga cactgaaact cagctcccgg gtgctggaca agatctccat cggccaactg      540

gtgtctctcc tgagcaataa cttgaataag ttcgacgaag ggctggccct ggcacacttc      600

gtgtggattg cccccctgca ggtggccctg ctgatgggac tgatttggga actgctgcag      660

gctagcgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg gcttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctgc ggaagatctt caccaccatc     1020

agcttttgca tcgtgcttag aatggccgtg acccggcagt tcccatgggc cgtgcaaact     1080

tggtatgatt ccctgggcgc catcaacaaa atccaggatt tcctgcagaa gcaggaatac     1140

aagacactcg aatataatct cacaactact gaggtggtta tggagaacgt gactgccttc     1200

tgggaggagg ggttcggaga gctttttgag aaggcaaaac agaataacaa caaccgcaaa     1260

accagcaacg gcgacgacag cctgttcttc tccaattttt ctctcctggg aacacccgtc     1320

ctcaaagaca tcaactttaa gatcgagagg ggacagctgc tcgcagtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc atccgagggc     1440

aagattaagc acagtggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaaattcg cagagaagga taatatcgtg     1620

ctgggggagg ggggaatcac cctgagcgga ggccagagag ccagaatctc actggcccgg     1680

gccgtctaca aggacgccga cctttacctt ctggacagtc cctttggata tctggatgtg     1740

ctgactgaaa aggagatctt cgagtcttgt gtgtgcaagc tgatggctaa taagacccgg     1800

atcctagtga ccagtaagat ggagcacctg aagaaggcag acaagatctt gattctgcac     1860

gagggatcct cttactttta cggcaccttt agcgagctgc agaatctcca gcccgatttc     1920

tcatctaagc tgatgggctg tgatagcttc gaccagttct ctgccgagcg cagaaacagc     1980

atcctgacag agacactgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttt ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

tccacactgc agtgggccgt gaatagttca atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagagggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaagctcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  4
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  4
atgcagcgtt ctcccctgga gaaggcttct gtggtgagta aacttttttt ctcctggacc       60

agacctatcc tgaggaaagg ctacaggcag agactggagc tctctgacat ataccagata      120

ccttcagtcg atagcgccga caacctgagc gagaagctgg aacgcgagtg ggacagagag      180

ctggcaagca agaagaaccc aaagctgatt aatgccctga gaaggtgttt cttctggaga      240

ttcatgttct acggaatctt tctgtatctg ggggaggtta caaaggctgt gcaacccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaaca aggaagaaag aagcatcgcc      360

atctacctgg gcattggcct ctgcctcctg tttattgtgc ggactctgct gctgcaccca      420

gcaattttcg ggttgcatca tattggcatg cagatgcgca ttgctatgtt ttccctcatc      480

tacaaaaaga cactgaaact cagctcccgg gtgctggaca agatctccat cggccaactg      540

gtgtctctcc tgagcaataa cttgaataag ttcgacgaag ggctggccct ggcacacttc      600

gtgtggattg cccccctgca ggtggccctg ctgatgggac tgatttggga actgctgcag      660

gctagcgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg ggttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctgc ggaagatctt caccaccatc     1020

agcttttgca tcgtgcttag aatggccgtg acccggcagt tcccatgggc cgtgcaaact     1080

tggtatgatt ccctgggcgc catcaacaaa atccaggatt tcctgcagaa gcaggaatac     1140

aagacactcg aatataatct cacaactact gaggtggtta tggagaacgt gactgccttc     1200

tgggaggagg ggttcggaga gctttttgag aaggcaaaac agaataacaa caaccgcaaa     1260

accagcaacg gcgacgacag cctgttcttc tccaattttt ctctcctggg aacacccgtc     1320

ctcaaagaca tcaactttaa gatcgagagg ggccagctgc tcgccgtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc ctccgagggc     1440

aagattaagc actcaggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaagttcg cagagaagga taatattgtg     1620

ctgggagagg gaggaatcac cctgagcgga ggccagagag ccagaatctc actggcccgg     1680

gccgtctaca aggacgccga cctttacctt ctggacagtc cctttggata tctggatgtg     1740

ctgactgaaa aggagatctt cgagtcttgt gtgtgcaagc tgatggctaa taagacccgg     1800

atcctagtga ccagtaagat ggagcacctg aagaaggcag acaagatctt gattctgcac     1860

gagggatcct cttactttta cggcaccttt agcgagctgc agaatctcca gcccgatttc     1920

tcatctaagc tgatgggctg tgatagcttc gaccagttct ctgccgagcg cagaaacagc     1980

atcctgacag agacactgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttt ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

agcacactgc agtgggccgt gaatagtagt atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagaaggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaaactcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  5
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  5
atgcagcgct cgcctctgga aaaggcgagc gtcgtgtcaa agctattctt ttcttggacc       60

cggcccattc tcaggaaggg ctacaggcag aggctggagt tgagcgacat ctatcagatt      120

ccttccgtgg acagcgccga caacctgagc gagaagctgg aaagggagtg ggaccgcgaa      180

ctggcaagca aaaagaaccc caagctgatc aatgccctga gaaggtgttt cttttggaga      240

ttcatgttct acgggatctt tctgtatctg ggcgaggtta caaaggctgt gcagcccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaaca aggaagaaag aagcatcgcc      360

atctacctgg gcattggcct ctgcctcctg tttattgtgc ggactctgct gctgcaccca      420

gcaattttcg ggttgcatca tattggcatg cagatgcgca ttgctatgtt ttccctcatc      480

tacaaaaaga cactgaaact cagctcccgg gtgctggaca agatctccat cggccaactg      540

gtgtctctcc tgagcaataa cttgaataag ttcgacgaag ggctggccct ggcacacttc      600

gtgtggattg cccccctgca ggtggccctg ctgatgggac tgatttggga actgctgcag      660

gctagcgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg gcttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctgc ggaagatctt caccaccatc     1020

agcttttgca tcgtgcttag aatggccgtg acacggcagt tcccatgggc cgttcaaact     1080

tggtatgatt ccctgggcgc catcaacaaa atccaggatt tcctgcagaa gcaggaatac     1140

aagacactcg aatataacct cacaactact gaggtggtta tggagaacgt gactgccttc     1200

tgggaggagg ggttcggaga gctttttgag aaggccaaac agaataataa taaccgcaaa     1260

accagcaacg gcgacgacag cctgttcttc tccaattttt ctctcctggg aacacccgtc     1320

ctcaaagaca tcaactttaa gatcgagagg ggacagctgc tcgcagtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc atccgagggc     1440

aagattaagc acagtggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaaattcg cagagaagga taatatcgtg     1620

ctgggggagg ggggaatcac cctgagcgga ggccagagag ccagaatctc actggcccgg     1680

gccgtctaca aggacgccga cctttacctt ctggacagtc cctttggata tctggatgtg     1740

ctgactgaaa aggagatctt cgagtcttgt gtgtgcaagc tgatggctaa caagacccgg     1800

atcctagtga ctagtaagat ggagcacctg aagaaggcag acaagatctt gattctgcac     1860

gagggatcct cttactttta cggcaccttt agcgagctgc agaacctcca gcccgatttc     1920

tcatctaagc tgatgggctg tgatagcttc gaccagttct ctgccgagcg cagaaacagc     1980

atcctgacag agacactgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttc ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

tccacactgc agtgggccgt gaatagttca atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagagggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaaactcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  6
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  6
atgcagcgtt ctcccctgga gaaggcttct gtggtgagta aacttttttt ctcctggacc       60

agacctatcc tgaggaaagg ctacaggcag agactggagc tctctgacat ataccagata      120

ccttcagtcg atagcgccga caacctgagc gagaagctgg aacgcgagtg ggacagagag      180

ctggcaagca agaagaaccc aaagctgatt aatgccctga gaaggtgttt cttctggaga      240

ttcatgttct acggaatctt tctgtatctg ggggaggtta caaaggctgt gcaacccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaaca aggaagaaag aagcatcgcc      360

atctacctgg gcattggcct ctgcctcctg tttattgtgc ggactctgct gctgcaccca      420

gcaattttcg ggttgcatca tattggcatg cagatgcgca ttgctatgtt ttccctcatc      480

tacaaaaaga cactgaaact cagctcccgg gtgctggaca agatctccat cggccaactg      540

gtgtctctcc tgagcaataa cttgaataag ttcgacgaag ggctggccct ggcacacttc      600

gtgtggattg cccccctgca ggtggccctg ctgatgggac tgatttggga actgctgcag      660

gctagcgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg gcttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctgc ggaagatctt caccaccatc     1020

agcttttgca tcgtgcttag aatggccgtg acccggcagt tcccatgggc cgtgcaaact     1080

tggtatgatt ccctgggcgc catcaacaaa atccaggatt tcctgcagaa gcaggaatac     1140

aagacactcg aatataatct cacaactact gaggtggtta tggagaacgt gactgccttc     1200

tgggaggagg ggttcggaga gctttttgag aaggcaaaac agaataacaa caaccgcaaa     1260

accagcaacg gcgacgacag cctgttcttc tccaattttt ctctcctggg aacacccgtc     1320

ctcaaagaca tcaactttaa gatcgagagg ggccagctgc tcgccgtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc ctccgagggc     1440

aagattaagc actcaggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaagttcg cagagaagga taatattgtg     1620

ctgggagagg gaggaatcac cctgagcgga ggccagagag ccagaatctc actggcccgg     1680

gccgtctaca aggacgccga cctttacctt ctggacagtc cctttggata tctggatgtg     1740

ctgactgaaa aggagatctt cgagtcttgt gtgtgcaagc tgatggctaa caagacccgg     1800

atcctagtga ctagtaagat ggagcacctg aagaaggcag acaagatctt gattctgcac     1860

gagggatcct cttactttta cggcaccttt agcgagctgc agaacctcca gcccgatttc     1920

tcatctaagc tgatgggctg tgatagcttc gaccagttct ctgccgagcg cagaaacagc     1980

atcctgacag agacactgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttc ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

tccacactgc agtgggccgt gaatagttca atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagagggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaaactcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  7
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  7
atgcagcgtt ctcccctgga gaaggcttct gtggtgagta aacttttttt ctcctggacc       60

agacctatcc tgaggaaagg ctacaggcag agactggagc tctctgacat ataccagata      120

ccttcagtcg atagcgccga caacctgagc gagaagctgg aacgcgagtg ggacagagag      180

ctggcaagca agaagaaccc aaagctgatt aatgccctga gaaggtgttt cttctggaga      240

ttcatgttct acggaatctt tctgtatctg ggggaggtta caaaggctgt gcaacccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaaca aggaagaaag aagcatcgcc      360

atctacctgg gcattggcct ctgcctcctg tttattgtgc ggactctgct gctgcaccca      420

gcaattttcg ggttgcatca tattggcatg cagatgcgca ttgctatgtt ttccctcatc      480

tacaaaaaga cactgaaact cagctcccgg gtgctggaca agatctccat cggccaactg      540

gtgtctctcc tgagcaataa cttgaataag ttcgacgaag ggctggccct ggcacacttc      600

gtgtggattg cccccctgca ggtggccctg ctgatgggac tgatttggga actgctgcag      660

gctagcgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg ggttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctgc ggaagatctt caccaccatc     1020

agcttttgca tcgtgcttag aatggccgtg acacggcagt tcccatgggc cgttcaaact     1080

tggtatgatt ccctgggcgc catcaacaaa atccaggatt tcctgcagaa gcaggaatac     1140

aagacactcg aatataacct cacaactact gaggtggtta tggagaacgt gactgccttc     1200

tgggaggagg ggttcggaga gctttttgag aaggccaaac agaataataa taaccgcaaa     1260

accagcaacg gcgacgacag cctgttcttc tccaattttt ctctcctggg aacacccgtc     1320

ctcaaagaca tcaactttaa gatcgagagg ggccagctgc tcgccgtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc ctccgagggc     1440

aagattaagc actcaggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaagttcg cagagaagga taatattgtg     1620

ctgggagagg gaggaatcac cctgagcgga ggccagagag ccagaatctc actggcccgg     1680

gccgtctaca aggacgccga cctttacctt ctggacagtc cctttggata tctggatgtg     1740

ctgactgaaa aggagatctt cgagtcttgt gtgtgcaagc tgatggctaa caagacccgg     1800

atcctagtga ctagtaagat ggagcacctg aagaaggcag acaagatctt gattctgcac     1860

gagggatcct cttactttta cggcaccttt agcgagctgc agaacctcca gcccgatttc     1920

tcatctaagc tgatgggctg tgatagcttc gaccagttct ctgccgagcg cagaaacagc     1980

atcctgacag agacactgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttc ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

agcacactgc agtgggccgt gaatagtagt atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagaaggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaagctcttt ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  8
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  8
atgcagcgtt ctcccctgga gaaggcttct gtggtgagta aacttttttt ctcctggacc       60

agacctatcc tgaggaaagg ctacaggcag agactggagc tctctgacat ataccagata      120

ccttcagtcg atagcgccga caacctgagc gagaagctgg aacgcgagtg ggacagagag      180

ctggcaagca agaagaaccc aaagctgatt aatgccctga gaaggtgttt cttctggaga      240

ttcatgttct acggaatctt tctgtatctg ggggaggtta caaaggctgt gcaacccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaata aggaagagag atctatcgcc      360

atctacctgg gaattggcct gtgtctgctg ttcatcgtgc gcaccctgct cctccaccca      420

gccatttttg ggctgcatca catcggaatg cagatgagga ttgctatgtt ttccctgatc      480

tataagaaga ccctgaaact ctcaagcaga gtgctggaca aaatttccat tggccagctg      540

gtgtctctgc tgtccaataa tctcaataag tttgacgagg gcctggccct ggcacacttc      600

gtctggattg cccctctcca ggtcgctctg ctgatgggcc tgatctggga gctgctgcag      660

gcatccgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg gcttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctga ggaagatctt cactacaatc     1020

tccttctgca tcgtactcag aatggccgtg acccgccagt ttccctgggc cgtgcagaca     1080

tggtacgact ccctcggcgc cattaataag atccaggatt ttctgcagaa acaggaatac     1140

aagacactgg aatacaacct gacaacaaca gaggtggtca tggaaaacgt gaccgcattt     1200

tgggaggaag gcttcggaga gctctttgaa aaagctaagc agaacaacaa taacaggaaa     1260

acctctaatg gggacgacag cctgtttttc agcaattttt ctctgctggg gacacctgtg     1320

ctgaaggaca ttaactttaa gatcgagagg ggacagctgc tcgcagtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc atccgagggc     1440

aagattaagc acagtggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaaattcg cagagaagga taatatcgtg     1620

ctgggggagg ggggaatcac cctgagcgga ggccagagag ccagaatcag cctggcaagg     1680

gcagtgtata aagacgctga cctgtacttg ctggactccc cttttggcta cctggacgtg     1740

ctgaccgaaa aggaaatctt tgagtcctgc gtctgcaagc tgatggcaaa caagaccaga     1800

atcctggtga cctccaagat ggaacatctg aagaaggcag ataaaatcct catcctgcat     1860

gagggatctt cttactttta tggaactttt agcgagctgc agaacctgca gccagacttc     1920

tccagcaagc tgatgggatg cgactccttt gaccagttct ccgccgaacg gcgcaattct     1980

atcctgaccg aaaccctgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttt ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

tccacactgc agtgggccgt gaatagttca atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagagggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaaactcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  9
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  9
atgcagcgct cgcctctgga aaaggcgagc gtcgtgtcaa agctattctt ttcttggacc       60

cggcccattc tcaggaaggg ctacaggcag aggctggagt tgagcgacat ctatcagatt      120

ccttccgtgg acagcgccga caacctgagc gagaagctgg aaagggagtg ggaccgcgaa      180

ctggcaagca aaaagaaccc caagctgatc aatgccctga gaaggtgttt cttttggaga      240

ttcatgttct acgggatctt tctgtatctg ggcgaggtta caaaggctgt gcagcccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaaca aggaagaaag aagcatcgcc      360

atctacctgg gcattggcct ctgcctcctg tttattgtgc ggactctgct gctgcaccca      420

gcaattttcg ggttgcatca tattggcatg cagatgcgca ttgctatgtt ttccctcatc      480

tacaaaaaga cactgaaact cagctcccgg gtgctggaca agatctccat cggccaactg      540

gtgtctctcc tgagcaataa cttgaataag ttcgacgaag ggctggccct ggcacacttc      600

gtgtggattg cccccctgca ggtggccctg ctgatgggac tgatttggga actgctgcag      660

gctagcgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg ggttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctgc ggaagatctt caccaccatc     1020

agcttttgca tcgtgcttag aatggccgtg acacggcagt tcccatgggc cgttcaaact     1080

tggtatgatt ccctgggcgc catcaacaaa atccaggatt tcctgcagaa gcaggaatac     1140

aagacactcg aatataacct cacaactact gaggtggtta tggagaacgt gactgccttc     1200

tgggaggagg ggttcggaga gctttttgag aaggccaaac agaataataa taaccgcaaa     1260

accagcaacg gcgacgacag cctgttcttc tccaattttt ctctcctggg aacacccgtc     1320

ctcaaagaca tcaactttaa gatcgagagg ggccagctgc tcgccgtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc ctccgagggc     1440

aagattaagc actcaggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaagttcg cagagaagga taatattgtg     1620

ctgggagagg gaggaatcac cctgagcgga ggccagagag ccagaatctc actggcccgg     1680

gccgtctaca aggacgccga cctttacctt ctggacagtc cctttggata tctggatgtg     1740

ctgactgaaa aggagatctt cgagtcttgt gtgtgcaagc tgatggctaa caagacccgg     1800

atcctagtga ctagtaagat ggagcacctg aagaaggcag acaagatctt gattctgcac     1860

gagggatcct cttactttta cggcaccttt agcgagctgc agaacctcca gcccgatttc     1920

tcatctaagc tgatgggctg tgatagcttc gaccagttct ctgccgagcg cagaaacagc     1980

atcctgacag agacactgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttc ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

agcacactgc agtgggccgt gaatagtagt atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagaaggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaaactcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  10
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  10
atgcagcgtt ctcccctgga gaaggcttct gtggtgagta aacttttttt ctcctggacc       60

agacctatcc tgaggaaagg ctacaggcag agactggagc tctctgacat ataccagata      120

ccttcagtcg atagcgccga caacctgagc gagaagctgg aacgcgagtg ggacagagag      180

ctggcaagca agaagaaccc aaagctgatt aatgccctga gaaggtgttt cttctggaga      240

ttcatgttct acggaatctt tctgtatctg ggggaggtta caaaggctgt gcaacccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaata aggaagagag atctatcgcc      360

atctacctgg gaattggcct gtgtctgctg ttcatcgtgc gcaccctgct cctccaccca      420

gccatttttg ggctgcatca catcggaatg cagatgagga ttgctatgtt ttccctgatc      480

tataagaaga ccctgaaact ctcaagcaga gtgctggaca aaatttccat tggccagctg      540

gtgtctctgc tgtccaataa tctcaataag tttgacgagg gcctggccct ggcacacttc      600

gtctggattg cccctctcca ggtcgctctg ctgatgggcc tgatctggga gctgctgcag      660

gcatccgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg ggttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctga ggaagatctt cactacaatc     1020

tccttctgca tcgtactcag aatggccgtg acccgccagt ttccctgggc cgtgcagaca     1080

tggtacgact ccctcggcgc cattaataag atccaggatt ttctgcagaa acaggaatac     1140

aagacactgg aatacaacct gacaacaaca gaggtggtca tggaaaacgt gaccgcattt     1200

tgggaggaag gcttcggaga gctctttgaa aaagctaagc agaacaacaa taacaggaaa     1260

acctctaatg gggacgacag cctgtttttc agcaattttt ctctgctggg gacacctgtg     1320

ctgaaggaca ttaactttaa gatcgagagg ggacagctgc tcgcagtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc atccgagggc     1440

aagattaagc acagtggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaaattcg cagagaagga taatatcgtg     1620

ctgggggagg ggggaatcac cctgagcgga ggccagagag ccagaatttc tctggccaga     1680

gccgtgtaca aagatgccga cctgtacctg ctggacagcc catttggcta tctggacgtg     1740

ctgaccgaaa aagagatttt cgagtcatgc gtttgtaagc tgatggccaa caagactcgc     1800

atcctggtga cttcgaagat ggaacatctg aagaaagctg ataagattct gatcctgcac     1860

gaaggcagct cctactttta cgggaccttc tccgagctcc agaacctgca gcctgatttc     1920

agctctaagc tgatgggctg cgatagcttt gaccagttta gcgcagaaag gcgcaactct     1980

attctgactg agacactgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttt ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

tccacactgc agtgggccgt gaatagttca atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagagggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaaactcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  11
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  11
atgcagcgct cgcctctgga aaaggcgagc gtcgtgtcaa agctattctt ttcttggacc       60

cggcccattc tcaggaaggg ctacaggcag aggctggagt tgagcgacat ctatcagatt      120

ccttccgtgg acagcgccga caacctgagc gagaagctgg aaagggagtg ggaccgcgaa      180

ctggcaagca aaaagaaccc caagctgatc aatgccctga gaaggtgttt cttttggaga      240

ttcatgttct acgggatctt tctgtatctg ggcgaggtta caaaggctgt gcagcccctg      300

ctgctcggca gaatcatcgc ctcatacgat ccagacaata aggaagagag atctatcgcc      360

atctacctgg gaattggcct gtgtctgctg ttcatcgtgc gcaccctgct cctccaccca      420

gccatttttg ggctgcatca catcggaatg cagatgagga ttgctatgtt ttccctgatc      480

tataagaaga ccctgaaact ctcaagcaga gtgctggaca aaatttccat tggccagctg      540

gtgtctctgc tgtccaataa tctcaataag tttgacgagg gcctggccct ggcacacttc      600

gtctggattg cccctctcca ggtcgctctg ctgatgggcc tgatctggga gctgctgcag      660

gcatccgctt tctgcggcct ggggttcctg atcgtgctgg cactgtttca ggcaggcctg      720

ggccgtatga tgatgaagta cagagaccag agggccggga agatctccga acggctcgtt      780

attacctctg agatgatcga gaacattcag tctgtgaaag cctactgctg ggaggaggct      840

atggagaaga tgatcgagaa tctgagacag accgagctga agctgaccag aaaggccgcc      900

tacgtgaggt acttcaacag cagtgccttc ttcttctctg gcttcttcgt tgtgtttctg      960

agcgtgctgc catacgctct catcaaaggc atcatcctga gaaaaatttt cacaaccatc     1020

tccttttgca tcgtgctgag aatggccgtg acaaggcagt tcccttgggc tgtgcagacc     1080

tggtacgaca gcctgggagc tattaataag attcaagatt tcctgcagaa gcaggaatac     1140

aaaacactgg aatacaacct gacaactact gaggtcgtta tggagaacgt gacagcattt     1200

tgggaggagg ggttcgggga actcttcgag aaggcaaagc agaacaacaa caatcggaag     1260

acatccaacg gcgacgacag cctgttcttt tccaacttca gcctgctggg aactccagtg     1320

ctcaaagaca ttaactttaa gatcgagagg ggccagctgc tcgccgtcgc cggatccaca     1380

ggcgccggca agacctctct gctgatggtt atcatgggcg aactggagcc ctccgagggc     1440

aagattaagc actcaggaag aatctccttt tgtagccagt tcagttggat tatgcccggc     1500

actattaagg agaatatcat ttttggggtg agctatgatg agtatcggta tcggagcgtt     1560

atcaaagcct gtcagctgga ggaggatatc agcaagttcg cagagaagga taatattgtg     1620

ctgggagagg gaggaatcac cctgagcgga ggccagagag ccagaattag cctcgcccgg     1680

gcagtctaca aagatgccga cctgtacctg ctggacagcc cttttggcta tttggatgtg     1740

ctgactgaaa aggaaatctt cgagagctgc gtgtgcaagc tgatggccaa caagacccgc     1800

atcctcgtca ctagcaagat ggaacacctg aagaaggccg acaagatcct gattctgcac     1860

gaggggagca gctacttcta tggcactttt tccgagctgc aaaatctcca gcctgacttc     1920

tcttccaagc tgatgggatg tgacagcttt gaccagtttt ccgctgagcg gcgcaatagc     1980

atcctgaccg aaaccctgca ccggttttca ctggagggcg acgcccctgt cagctggacc     2040

gagaccaaaa agcagtcttt caagcagaca ggcgagttcg gcgagaagcg caaaaacagc     2100

atcctgaatc caatcaactc tataaggaag tttagcatcg tgcagaagac acccctccag     2160

atgaacggca tcgaagagga cagtgacgag cccctggagc ggcgcctgag cctcgtgcct     2220

gacagcgaac agggcgaggc catcctgcct aggatcagcg tgatttcaac cgggccaaca     2280

ctgcaggcta ggagaagaca gtcagtgctt aacctgatga cacatagcgt gaatcaggga     2340

cagaacatcc atcgaaaaac cacagcctct actcgcaaag tgtcactggc tcctcaggct     2400

aatctgacag agctggacat ctatagcagg aggctgagcc aggagacagg cctggagatc     2460

agtgaggaga tcaacgaaga ggacctgaag gagtgctttt tcgatgacat ggagagtatc     2520

cccgccgtca ccacctggaa tacctacctc cggtacatca cagtgcacaa gtccctcatc     2580

tttgtgctga tttggtgcct cgtgatcttt ctcgcagaag tggccgcctc cctggtggtg     2640

ctgtggctgt tggggaatac tccactgcag gacaaaggca attctacaca cagcaggaat     2700

aattcctatg ccgtgattat caccagcaca tcctcttact acgtgttcta catctacgtg     2760

ggagtggcag atactctgct tgcaatgggc ttcttcaggg ggctgcccct ggtgcacaca     2820

ctgatcacag tgtccaagat cctccaccat aaaatgctcc acagcgtgct gcaggcaccc     2880

atgagcaccc tgaacacact gaaggccggc ggcatcctga atcgcttttc caaagacatc     2940

gccatcctcg acgatctcct gccactgacc atcttcgatt ttatccagct gctgctgatc     3000

gtgatcgggg ccatcgccgt ggtggccgtg ctgcagccat acattttcgt ggctacagtg     3060

cccgtgatcg ttgcctttat catgctgaga gcctacttcc tgcagacttc tcagcagctg     3120

aagcagctgg agagcgaagg gagaagcccc atcttcactc acctggtgac aagcctgaag     3180

ggactctgga ccctgagagc cttcggccgg cagccctatt tcgagaccct gtttcacaag     3240

gccctcaacc tgcacacagc caactggttc ctctacctgt ccaccctgag gtggttccag     3300

atgaggattg aaatgatctt cgtgattttt ttcatcgccg tgacattcat tagcattctg     3360

accaccggcg agggggaggg gagagtgggc atcatcctga cccttgccat gaacattatg     3420

agcacactgc agtgggccgt gaatagtagt atcgacgtgg acagtctgat gaggtccgtg     3480

agccgggtgt tcaagttcat tgacatgccc acagaaggga aacccaccaa aagcaccaag     3540

ccctacaaga acgggcagct gtccaaggtt atgatcatcg agaactctca cgtgaagaag     3600

gacgacattt ggcccagcgg cggccagatg acagtgaaag atctgaccgc caaatacacc     3660

gagggaggca acgccatcct cgaaaacatt agcttctcta tcagccctgg acagagggtg     3720

ggcctgctgg gccggacagg ctcagggaag agtactctgc tgtcagcatt cctgaggctc     3780

ctgaacacag agggcgagat ccagattgac ggcgtgtcct gggactccat caccctgcag     3840

cagtggcgga aggctttcgg ggtgatcccc cagaaggtgt tcatctttag cggcactttc     3900

agaaagaatc tggaccctta tgagcagtgg agtgaccagg agatctggaa agtggccgat     3960

gaggtcggac tgaggagcgt gatcgagcag tttccaggga agctggactt tgtgctggtg     4020

gatggcggat gcgtgctgtc tcacggccat aaacagctga tgtgtctggc ccggtccgtg     4080

ctgtctaagg ccaagatcct gctgctggac gaaccctccg cccacctgga ccccgtgaca     4140

taccagatca tcaggagaac tctcaagcag gccttcgccg actgtaccgt gattctgtgc     4200

gagcaccgca ttgaagctat gctggagtgt cagcagttcc tggtgatcga ggaaaataag     4260

gtgaggcagt acgacagcat ccagaagctg ctgaacgagc gctccctgtt ccgccaggct     4320

atctccccat cagaccgggt gaaactcttc ccccacagaa actcctcaaa gtgcaagtcc     4380

aagccccaga tcgccgccct gaaggaggag accgaggagg aggtgcagga caccaggctg     4440

tga                                                                   4443


<210>  12
<211>  140
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  12
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg                                                  140


<210>  13
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  13
cggguggcau cccugugacc ccuccccagu gccucuccug gcccuggaag uugccacucc       60

agugcccacc agccuugucc uaauaaaauu aaguugcauc aagcu                      105


<210>  14
<211>  105
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  14
ggguggcauc ccugugaccc cuccccagug ccucuccugg cccuggaagu ugccacucca       60

gugcccacca gccuuguccu aauaaaauua aguugcauca aagcu                      105


<210>  15
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  15
atgcaacgct ctcctcttga aaaggcctcg gtggtgtcca agctcttctt ctcgtggact       60

agacccatcc tgagaaaggg gtacagacag cgcttggagc tgtccgatat ctatcaaatc      120

ccttccgtgg actccgcgga caacctgtcc gagaagctcg agagagaatg ggacagagaa      180

ctcgcctcaa agaagaaccc gaagctgatt aatgcgctta ggcggtgctt tttctggcgg      240

ttcatgttct acggcatctt cctctacctg ggagaggtca ccaaggccgt gcagcccctg      300

ttgctgggac ggattattgc ctcctacgac cccgacaaca aggaagaaag aagcatcgct      360

atctacttgg gcatcggtct gtgcctgctt ttcatcgtcc ggaccctctt gttgcatcct      420

gctattttcg gcctgcatca cattggcatg cagatgagaa ttgccatgtt ttccctgatc      480

tacaagaaaa ctctgaagct ctcgagccgc gtgcttgaca agatttccat cggccagctc      540

gtgtccctgc tctccaacaa tctgaacaag ttcgacgagg gcctcgccct ggcccacttc      600

gtgtggatcg cccctctgca agtggcgctt ctgatgggcc tgatctggga gctgctgcaa      660

gcctcggcat tctgtgggct tggattcctg atcgtgctgg cactgttcca ggccggactg      720

gggcggatga tgatgaagta cagggaccag agagccggaa agatttccga acggctggtg      780

atcacttcgg aaatgatcga aaacatccag tcagtgaagg cctactgctg ggaagaggcc      840

atggaaaaga tgattgaaaa cctccggcaa accgagctga agctgacccg caaggccgct      900

tacgtgcgct atttcaactc gtccgctttc ttcttctccg ggttcttcgt ggtgtttctc      960

tccgtgctcc cctacgccct gattaaggga atcatcctca ggaagatctt caccaccatt     1020

tccttctgta tcgtgctccg catggccgtg acccggcagt tcccatgggc cgtgcagact     1080

tggtacgact ccctgggagc cattaacaag atccaggact tccttcaaaa gcaggagtac     1140

aagaccctcg agtacaacct gactactacc gaggtcgtga tggaaaacgt caccgccttt     1200

tgggaggagg gatttggcga actgttcgag aaggccaagc agaacaacaa caaccgcaag     1260

acctcgaacg gtgacgactc cctcttcttt tcaaacttca gcctgctcgg gacgcccgtg     1320

ctgaaggaca ttaacttcaa gatcgaaaga ggacagctcc tggcggtggc cggatcgacc     1380

ggagccggaa agacttccct gctgatggtg atcatgggag agcttgaacc tagcgaggga     1440

aagatcaagc actccggccg catcagcttc tgtagccagt tttcctggat catgcccgga     1500

accattaagg aaaacatcat cttcggcgtg tcctacgatg aataccgcta ccggtccgtg     1560

atcaaagcct gccagctgga agaggatatt tcaaagttcg cggagaaaga taacatcgtg     1620

ctgggcgaag ggggtattac cttgtcgggg ggccagcggg ctagaatctc gctggccaga     1680

gccgtgtata aggacgccga cctgtatctc ctggactccc ccttcggata cctggacgtc     1740

ctgaccgaaa aggagatctt cgaatcgtgc gtgtgcaagc tgatggctaa caagactcgc     1800

atcctcgtga cctccaaaat ggagcacctg aagaaggcag acaagattct gattctgcat     1860

gaggggtcct cctactttta cggcaccttc tcggagttgc agaacttgca gcccgacttc     1920

tcatcgaagc tgatgggttg cgacagcttc gaccagttct ccgccgaaag aaggaactcg     1980

atcctgacgg aaaccttgca ccgcttctct ttggaaggcg acgcccctgt gtcatggacc     2040

gagactaaga agcagagctt caagcagacc ggggaattcg gcgaaaagag gaagaacagc     2100

atcttgaacc ccattaactc catccgcaag ttctcaatcg tgcaaaagac gccactgcag     2160

atgaacggca ttgaggagga ctccgacgaa ccccttgaga ggcgcctgtc cctggtgccg     2220

gacagcgagc agggagaagc catcctgcct cggatttccg tgatctccac tggtccgacg     2280

ctccaagccc ggcggcggca gtccgtgctg aacctgatga cccacagcgt gaaccagggc     2340

caaaacattc accgcaagac taccgcatcc acccggaaag tgtccctggc acctcaagcg     2400

aatcttaccg agctcgacat ctactcccgg agactgtcgc aggaaaccgg gctcgaaatt     2460

tccgaagaaa tcaacgagga ggatctgaaa gagtgcttct tcgacgatat ggagtcgata     2520

cccgccgtga cgacttggaa cacttatctg cggtacatca ctgtgcacaa gtcattgatc     2580

ttcgtgctga tttggtgcct ggtgattttc ctggccgagg tcgcggcctc actggtggtg     2640

ctctggctgt tgggaaacac gcctctgcaa gacaagggaa actccacgca ctcgagaaac     2700

aacagctatg ccgtgattat cacttccacc tcctcttatt acgtgttcta catctacgtc     2760

ggagtggcgg ataccctgct cgcgatgggt ttcttcagag gactgccgct ggtccacacc     2820

ttgatcaccg tcagcaagat tcttcaccac aagatgttgc atagcgtgct gcaggccccc     2880

atgtccaccc tcaacactct gaaggccgga ggcattctga acagattctc caaggacatc     2940

gctatcctgg acgatctcct gccgcttacc atctttgact tcatccagct gctgctgatc     3000

gtgattggag caatcgcagt ggtggcggtg ctgcagcctt acattttcgt ggccactgtg     3060

ccggtcattg tggcgttcat catgctgcgg gcctacttcc tccaaaccag ccagcagctg     3120

aagcaactgg aatccgaggg acgatccccc atcttcactc accttgtgac gtcgttgaag     3180

ggactgtgga ccctccgggc tttcggacgg cagccctact tcgaaaccct cttccacaag     3240

gccctgaacc tccacaccgc caattggttc ctgtacctgt ccaccctgcg gtggttccag     3300

atgcgcatcg agatgatttt cgtcatcttc ttcatcgcgg tcacattcat cagcatcctg     3360

actaccggag agggagaggg acgggtcgga ataatcctga ccctcgccat gaacattatg     3420

agcaccctgc agtgggcagt gaacagctcg atcgacgtgg acagcctgat gcgaagcgtc     3480

agccgcgtgt tcaagttcat cgacatgcct actgagggaa aacccactaa gtccactaag     3540

ccctacaaaa atggccagct gagcaaggtc atgatcatcg aaaactccca cgtgaagaag     3600

gacgatattt ggccctccgg aggtcaaatg accgtgaagg acctgaccgc aaagtacacc     3660

gagggaggaa acgccattct cgaaaacatc agcttctcca tttcgccggg acagcgggtc     3720

ggccttctcg ggcggaccgg ttccgggaag tcaactctgc tgtcggcttt cctccggctg     3780

ctgaataccg agggggaaat ccaaattgac ggcgtgtctt gggattccat tactctgcag     3840

cagtggcgga aggccttcgg cgtgatcccc cagaaggtgt tcatcttctc gggtaccttc     3900

cggaagaacc tggatcctta cgagcagtgg agcgaccaag aaatctggaa ggtcgccgac     3960

gaggtcggcc tgcgctccgt gattgaacaa tttcctggaa agctggactt cgtgctcgtc     4020

gacgggggat gtgtcctgtc gcacggacat aagcagctca tgtgcctcgc acggtccgtg     4080

ctctccaagg ccaagattct gctgctggac gaaccttcgg cccacctgga tccggtcacc     4140

taccagatca tcaggaggac cctgaagcag gcctttgccg attgcaccgt gattctctgc     4200

gagcaccgca tcgaggccat gctggagtgc cagcagttcc tggtcatcga ggagaacaag     4260

gtccgccaat acgactccat tcaaaagctc ctcaacgagc ggtcgctgtt cagacaagct     4320

atttcaccgt ccgatagagt gaagctcttc ccgcatcgga acagctcaaa gtgcaaatcg     4380

aagccgcaga tcgcagcctt gaaggaagag actgaggaag aggtgcagga cacccggctt     4440

taa                                                                   4443


<210>  16
<211>  4443
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  16
atgcagcggt ccccgctcga aaaggccagt gtcgtgtcca aactcttctt ctcatggact       60

cggcctatcc ttagaaaggg gtatcggcag aggcttgagt tgtctgacat ctaccagatc      120

ccctcggtag attcggcgga taacctctcg gagaagctcg aacgggaatg ggaccgcgaa      180

ctcgcgtcta agaaaaaccc gaagctcatc aacgcactga gaaggtgctt cttctggcgg      240

ttcatgttct acggtatctt cttgtatctc ggggaggtca caaaagcagt ccaacccctg      300

ttgttgggtc gcattatcgc ctcgtacgac cccgataaca aagaagaacg gagcatcgcg      360

atctacctcg ggatcggact gtgtttgctt ttcatcgtca gaacactttt gttgcatcca      420

gcaatcttcg gcctccatca catcggtatg cagatgcgaa tcgctatgtt tagcttgatc      480

tacaaaaaga cactgaaact ctcgtcgcgg gtgttggata agatttccat cggtcagttg      540

gtgtccctgc ttagtaataa cctcaacaaa ttcgatgagg gactggcgct ggcacatttc      600

gtgtggattg ccccgttgca agtcgccctt ttgatgggcc ttatttggga actcttgcag      660

gcatctgcct tttgtggcct gggatttctg attgtgttgg cattgtttca ggctgggctt      720

gggcggatga tgatgaagta tcgcgaccag agagcgggta aaatctcgga aagactcgtc      780

atcacttcgg aaatgatcga aaacatccag tcggtcaaag cctattgctg ggaagaagct      840

atggagaaga tgattgaaaa cctccgccaa actgagctga aactgacccg caaggcggcg      900

tatgtccggt atttcaattc gtcagcgttc ttcttttccg ggttcttcgt tgtctttctc      960

tcggttttgc cttatgcctt gattaagggg attatcctcc gcaagatttt caccacgatt     1020

tcgttctgca ttgtattgcg catggcagtg acacggcaat ttccgtgggc cgtgcagaca     1080

tggtatgact cgcttggagc gatcaacaaa atccaagact tcttgcaaaa gcaagagtac     1140

aagaccctgg agtacaatct tactactacg gaggtagtaa tggagaatgt gacggctttt     1200

tgggaagagg gttttggaga gctcttcgag aaagcaaagc agaataacaa caaccgcaag     1260

acctcaaatg gggacgattc cctgtttttc tcgaacttct ccctgctcgg aacacccgtg     1320

ttgaaggaca tcaatttcaa gattgagagg ggacagcttc tcgcggtagc gggaagcact     1380

ggtgcgggaa aaactagcct cttgatggtg attatggggg agcttgagcc cagcgagggg     1440

aagattaaac actccgggcg tatctcattc tgtagccagt tttcatggat catgcccgga     1500

accattaaag agaacatcat tttcggagta tcctatgatg agtaccgata cagatcggtc     1560

attaaggcgt gccagttgga agaggacatt tctaagttcg ccgagaagga taacatcgtc     1620

ttgggagaag ggggtattac attgtcggga gggcagcgag cgcggatcag cctcgcgaga     1680

gcggtataca aagatgcaga tttgtacctg ctcgattcac cgtttggata cctcgacgta     1740

ttgacagaaa aagaaatctt cgagtcgtgc gtgtgtaaac ttatggctaa taagacgaga     1800

atcctggtga catcaaaaat ggaacacctt aagaaggcgg acaagatcct gatcctccac     1860

gaaggatcgt cctactttta cggcactttc tcagagttgc aaaacttgca gccggacttc     1920

tcaagcaaac tcatggggtg tgactcattc gaccagttca gcgcggaacg gcggaactcg     1980

atcttgacgg aaacgctgca ccgattctcg cttgagggtg atgccccggt atcgtggacc     2040

gagacaaaga agcagtcgtt taagcagaca ggagaatttg gtgagaaaag aaagaacagt     2100

atcttgaatc ctattaactc aattcgcaag ttctcaatcg tccagaaaac tccactgcag     2160

atgaatggaa ttgaagagga ttcggacgaa cccctggagc gcaggcttag cctcgtgccg     2220

gattcagagc aaggggaggc cattcttccc cggatttcgg tgatttcaac cggacctaca     2280

cttcaggcga ggcgaaggca atccgtgctc aacctcatga cgcattcggt aaaccagggg     2340

caaaacattc accgcaaaac gacggcctca acgagaaaag tgtcacttgc accccaggcg     2400

aatttgactg aactcgacat ctacagccgt aggctttcgc aagaaaccgg acttgagatc     2460

agcgaagaaa tcaatgaaga agatttgaaa gagtgtttct ttgatgacat ggaatcaatc     2520

ccagcggtga caacgtggaa cacatacttg cgttacatca cggtgcacaa gtccttgatt     2580

ttcgtcctca tttggtgcct cgtgatcttt ctcgctgagg tcgcagcgtc acttgtggtc     2640

ctctggctgc ttggtaatac gcccttgcaa gacaaaggca attctacaca ctcaagaaac     2700

aattcctatg ccgtgattat cacttctaca agctcgtatt acgtgtttta catctacgta     2760

ggagtggccg acactctgct cgcgatgggt ttcttccgag gactcccact cgttcacacg     2820

cttatcactg tctccaagat tctccaccat aagatgcttc atagcgtact gcaggctccc     2880

atgtccacct tgaatacgct caaggcggga ggtattttga atcgcttctc aaaagatatt     2940

gcaattttgg atgaccttct gcccctgacg atcttcgact tcatccagtt gttgctgatc     3000

gtgattgggg ctattgcagt agtcgctgtc ctccagcctt acatttttgt cgcgaccgtt     3060

ccggtgatcg tggcgtttat catgctgcgg gcctatttct tgcagacgtc acagcagctt     3120

aagcaactgg agtctgaagg gaggtcgcct atctttacgc atcttgtgac cagtttgaag     3180

ggattgtgga cgttgcgcgc ctttggcagg cagccctact ttgaaacact gttccacaaa     3240

gcgctgaatc tccatacggc aaattggttt ttgtatttga gtaccctccg atggtttcag     3300

atgcgcattg agatgatttt tgtgatcttc tttatcgcgg tgacttttat ctccatcttg     3360

accacgggag agggcgaggg acgggtcggt attatcctga cactcgccat gaacattatg     3420

agcactttgc agtgggcagt gaacagctcg attgatgtgg atagcctgat gaggtccgtt     3480

tcgagggtct ttaagttcat cgacatgccg acggagggaa agcccacaaa aagtacgaaa     3540

ccctataaga atgggcaatt gagtaaggta atgatcatcg agaacagtca cgtgaagaag     3600

gatgacatct ggcctagcgg gggtcagatg accgtgaagg acctgacggc aaaatacacc     3660

gagggaggga acgcaatcct tgaaaacatc tcgttcagca ttagccccgg tcagcgtgtg     3720

gggttgctcg ggaggaccgg gtcaggaaaa tcgacgttgc tgtcggcctt cttgagactt     3780

ctgaatacag agggtgagat ccagatcgac ggcgtttcgt gggatagcat caccttgcag     3840

cagtggcgga aagcgtttgg agtaatcccc caaaaggtct ttatctttag cggaaccttc     3900

cgaaagaatc tcgatcctta tgaacagtgg tcagatcaag agatttggaa agtcgcggac     3960

gaggttggcc ttcggagtgt aatcgagcag tttccgggaa aactcgactt tgtccttgta     4020

gatgggggat gcgtcctgtc gcatgggcac aagcagctca tgtgcctggc gcgatccgtc     4080

ctctctaaag cgaaaattct tctcttggat gaaccttcgg cccatctgga cccggtaacg     4140

tatcagatca tcagaaggac acttaagcag gcgtttgccg actgcacggt gattctctgt     4200

gagcatcgta tcgaggccat gctcgaatgc cagcaatttc ttgtcatcga agagaataag     4260

gtccgccagt acgactccat ccagaagctg cttaatgaga gatcattgtt ccggcaggcg     4320

atttcaccat ccgatagggt gaaacttttt ccacacagaa attcgtcgaa gtgcaagtcc     4380

aaaccgcaga tcgcggcctt gaaagaagag actgaagaag aagttcaaga cacgcgtctt     4440

taa                                                                   4443


<210>  17
<211>  874
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Gln Asp Leu His Ala Ile Gln Leu Gln Leu Glu Glu Glu Met Phe 
1               5                   10                  15      


Asn Gly Gly Ile Arg Arg Phe Glu Ala Asp Gln Gln Arg Gln Ile Ala 
            20                  25                  30          


Ala Gly Ser Glu Ser Asp Thr Ala Trp Asn Arg Arg Leu Leu Ser Glu 
        35                  40                  45              


Leu Ile Ala Pro Met Ala Glu Gly Ile Gln Ala Tyr Lys Glu Glu Tyr 
    50                  55                  60                  


Glu Gly Lys Lys Gly Arg Ala Pro Arg Ala Leu Ala Phe Leu Gln Cys 
65                  70                  75                  80  


Val Glu Asn Glu Val Ala Ala Tyr Ile Thr Met Lys Val Val Met Asp 
                85                  90                  95      


Met Leu Asn Thr Asp Ala Thr Leu Gln Ala Ile Ala Met Ser Val Ala 
            100                 105                 110         


Glu Arg Ile Glu Asp Gln Val Arg Phe Ser Lys Leu Glu Gly His Ala 
        115                 120                 125             


Ala Lys Tyr Phe Glu Lys Val Lys Lys Ser Leu Lys Ala Ser Arg Thr 
    130                 135                 140                 


Lys Ser Tyr Arg His Ala His Asn Val Ala Val Val Ala Glu Lys Ser 
145                 150                 155                 160 


Val Ala Glu Lys Asp Ala Asp Phe Asp Arg Trp Glu Ala Trp Pro Lys 
                165                 170                 175     


Glu Thr Gln Leu Gln Ile Gly Thr Thr Leu Leu Glu Ile Leu Glu Gly 
            180                 185                 190         


Ser Val Phe Tyr Asn Gly Glu Pro Val Phe Met Arg Ala Met Arg Thr 
        195                 200                 205             


Tyr Gly Gly Lys Thr Ile Tyr Tyr Leu Gln Thr Ser Glu Ser Val Gly 
    210                 215                 220                 


Gln Trp Ile Ser Ala Phe Lys Glu His Val Ala Gln Leu Ser Pro Ala 
225                 230                 235                 240 


Tyr Ala Pro Cys Val Ile Pro Pro Arg Pro Trp Arg Thr Pro Phe Asn 
                245                 250                 255     


Gly Gly Phe His Thr Glu Lys Val Ala Ser Arg Ile Arg Leu Val Lys 
            260                 265                 270         


Gly Asn Arg Glu His Val Arg Lys Leu Thr Gln Lys Gln Met Pro Lys 
        275                 280                 285             


Val Tyr Lys Ala Ile Asn Ala Leu Gln Asn Thr Gln Trp Gln Ile Asn 
    290                 295                 300                 


Lys Asp Val Leu Ala Val Ile Glu Glu Val Ile Arg Leu Asp Leu Gly 
305                 310                 315                 320 


Tyr Gly Val Pro Ser Phe Lys Pro Leu Ile Asp Lys Glu Asn Lys Pro 
                325                 330                 335     


Ala Asn Pro Val Pro Val Glu Phe Gln His Leu Arg Gly Arg Glu Leu 
            340                 345                 350         


Lys Glu Met Leu Ser Pro Glu Gln Trp Gln Gln Phe Ile Asn Trp Lys 
        355                 360                 365             


Gly Glu Cys Ala Arg Leu Tyr Thr Ala Glu Thr Lys Arg Gly Ser Lys 
    370                 375                 380                 


Ser Ala Ala Val Val Arg Met Val Gly Gln Ala Arg Lys Tyr Ser Ala 
385                 390                 395                 400 


Phe Glu Ser Ile Tyr Phe Val Tyr Ala Met Asp Ser Arg Ser Arg Val 
                405                 410                 415     


Tyr Val Gln Ser Ser Thr Leu Ser Pro Gln Ser Asn Asp Leu Gly Lys 
            420                 425                 430         


Ala Leu Leu Arg Phe Thr Glu Gly Arg Pro Val Asn Gly Val Glu Ala 
        435                 440                 445             


Leu Lys Trp Phe Cys Ile Asn Gly Ala Asn Leu Trp Gly Trp Asp Lys 
    450                 455                 460                 


Lys Thr Phe Asp Val Arg Val Ser Asn Val Leu Asp Glu Glu Phe Gln 
465                 470                 475                 480 


Asp Met Cys Arg Asp Ile Ala Ala Asp Pro Leu Thr Phe Thr Gln Trp 
                485                 490                 495     


Ala Lys Ala Asp Ala Pro Tyr Glu Phe Leu Ala Trp Cys Phe Glu Tyr 
            500                 505                 510         


Ala Gln Tyr Leu Asp Leu Val Asp Glu Gly Arg Ala Asp Glu Phe Arg 
        515                 520                 525             


Thr His Leu Pro Val His Gln Asp Gly Ser Cys Ser Gly Ile Gln His 
    530                 535                 540                 


Tyr Ser Ala Met Leu Arg Asp Glu Val Gly Ala Lys Ala Val Asn Leu 
545                 550                 555                 560 


Lys Pro Ser Asp Ala Pro Gln Asp Ile Tyr Gly Ala Val Ala Gln Val 
                565                 570                 575     


Val Ile Lys Lys Asn Ala Leu Tyr Met Asp Ala Asp Asp Ala Thr Thr 
            580                 585                 590         


Phe Thr Ser Gly Ser Val Thr Leu Ser Gly Thr Glu Leu Arg Ala Met 
        595                 600                 605             


Ala Ser Ala Trp Asp Ser Ile Gly Ile Thr Arg Ser Leu Thr Lys Lys 
    610                 615                 620                 


Pro Val Met Thr Leu Pro Tyr Gly Ser Thr Arg Leu Thr Cys Arg Glu 
625                 630                 635                 640 


Ser Val Ile Asp Tyr Ile Val Asp Leu Glu Glu Lys Glu Ala Gln Lys 
                645                 650                 655     


Ala Val Ala Glu Gly Arg Thr Ala Asn Lys Val His Pro Phe Glu Asp 
            660                 665                 670         


Asp Arg Gln Asp Tyr Leu Thr Pro Gly Ala Ala Tyr Asn Tyr Met Thr 
        675                 680                 685             


Ala Leu Ile Trp Pro Ser Ile Ser Glu Val Val Lys Ala Pro Ile Val 
    690                 695                 700                 


Ala Met Lys Met Ile Arg Gln Leu Ala Arg Phe Ala Ala Lys Arg Asn 
705                 710                 715                 720 


Glu Gly Leu Met Tyr Thr Leu Pro Thr Gly Phe Ile Leu Glu Gln Lys 
                725                 730                 735     


Ile Met Ala Thr Glu Met Leu Arg Val Arg Thr Cys Leu Met Gly Asp 
            740                 745                 750         


Ile Lys Met Ser Leu Gln Val Glu Thr Asp Ile Val Asp Glu Ala Ala 
        755                 760                 765             


Met Met Gly Ala Ala Ala Pro Asn Phe Val His Gly His Asp Ala Ser 
    770                 775                 780                 


His Leu Ile Leu Thr Val Cys Glu Leu Val Asp Lys Gly Val Thr Ser 
785                 790                 795                 800 


Ile Ala Val Ile His Asp Ser Phe Gly Thr His Ala Asp Asn Thr Leu 
                805                 810                 815     


Thr Leu Arg Val Ala Leu Lys Gly Gln Met Val Ala Met Tyr Ile Asp 
            820                 825                 830         


Gly Asn Ala Leu Gln Lys Leu Leu Glu Glu His Glu Val Arg Trp Met 
        835                 840                 845             


Val Asp Thr Gly Ile Glu Val Pro Glu Gln Gly Glu Phe Asp Leu Asn 
    850                 855                 860                 


Glu Ile Met Asp Ser Glu Tyr Val Phe Ala 
865                 870                 


