                         SEQUENCE LISTING

<110>  2seventy bio, Inc.
       Inhibrx, Inc.
       Jarjour, Jordan
       Mark, Pogson
       Leung, Wai-Hang
       Astrakhan, Alexander
       Jones, Kyle S.
       William, Crago
       Sanabria, Angelica
       Andrew, Hollands
       Gano, Jacob
       Ma, Milton
       Timmer, John C.
       Eckelman, Brendan P
 
<120>  CD33 TARGETED IMMUNOTHERAPIES

<130>  BLUE-134.PC

<150>  US 63/111,280
<151>  2020-11-09

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  364
<212>  PRT
<213>  Homo Sapiens

<400>  1

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 
            20                  25                  30          


Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 
        35                  40                  45              


Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 
    50                  55                  60                  


Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 
65                  70                  75                  80  


Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 
                85                  90                  95      


Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 
            100                 105                 110         


Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 
        115                 120                 125             


Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 
    130                 135                 140                 


Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 
145                 150                 155                 160 


Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 
                165                 170                 175     


Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 
            180                 185                 190         


His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 
        195                 200                 205             


Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 
    210                 215                 220                 


Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 
225                 230                 235                 240 


Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 
                245                 250                 255     


Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 
            260                 265                 270         


Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 
        275                 280                 285             


Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 
    290                 295                 300                 


Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 
305                 310                 315                 320 


Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 
                325                 330                 335     


Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 
            340                 345                 350         


Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 
        355                 360                 


<210>  2
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  2

Gln Val Thr Leu Arg Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Gly Ser Gly Arg Ala Ile Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Gly His Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Asp Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Ala Tyr Ser Asp Tyr His Arg Ile Ala Thr Met Glu Ala Asp Ala 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Ser Gly Asn Asn Leu Ser Thr Glu Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Tyr Asp Tyr Ser Ser Gly Asp Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Lys Pro 
        115                 120 


<210>  4
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe Ser Ala Ser 
            20                  25                  30          


Leu Met Ser Trp His Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Arg Asp Gly Arg Ala Asn Tyr Val Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Tyr Ser Phe Asp Tyr Pro Ile Arg Ser Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Lys Pro 
        115             


<210>  5
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Thr Thr Ser Gly Asp Thr Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Gly Gly Gly Val Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Lys Pro 
        115             


<210>  6
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Ser 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Thr Thr Ser Ser Gly Thr Thr Asn Tyr Val Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Tyr Ile Ala Thr Thr Thr Asp Arg Gly Tyr Arg Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Lys Pro 
        115                 120     


<210>  7
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Tyr Asn 
            20                  25                  30          


Val Val Gly Trp Tyr Arg Gln Leu Ser Gly Asn Glu Arg Gly Gly Arg 
        35                  40                  45              


Thr Met Val Ala Gln Ile Asn Ala Tyr Gly Asp Thr Asn Tyr Ala Asn 
    50                  55                  60                  


Ala Val Val Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu His Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Asn Gly Gln Arg Met Leu Glu Asn Tyr Thr Tyr Arg Asp Gln 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Lys Pro 
        115                 120                 


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Lys Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Lys Pro 
        115     


<210>  9
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  9

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Asn Ile Asp 
            20                  25                  30          


His Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Gly Val Ile Ser Ser Gly Ala Gly Pro Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Asn Cys Asn 
                85                  90                  95      


Ala Trp Ile Asp Tyr Gly Ser Gly Leu Pro Gln Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Lys Pro 
        115                 120 


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Lys Pro 
        115     


<210>  11
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Asn Ile Asp 
            20                  25                  30          


His Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Gly Val Ile Ser Ser Gly Ala Gly Pro Asn Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Trp Ile Asp Tyr Gly Ser Gly Leu Pro Gln Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Lys Pro 
        115                 120 


<210>  12
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (124)..(125)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Gln Val Thr Leu Arg Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Gly Ser Gly Arg Ala Ile Asn Thr Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Asn Gly Gly His Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Gln Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Asp Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Ala Tyr Ser Asp Tyr His Arg Ile Ala Thr Met Glu Ala Asp Ala 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Xaa Xaa 
        115                 120                 125 


<210>  13
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (119)..(120)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Gly Tyr 
            20                  25                  30          


Ile Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Arg Ile Ser Gly Asn Asn Leu Ser Thr Glu Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Glu Tyr Asp Tyr Ser Ser Gly Asp Phe Val Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Xaa Xaa 
        115                 120 


<210>  14
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (117)..(118)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Gly Phe Ser Ala Ser 
            20                  25                  30          


Leu Met Ser Trp His Arg Gln Ala Pro Gly Lys Gln Arg Asp Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Arg Asp Gly Arg Ala Asn Tyr Val Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Tyr Ser Phe Asp Tyr Pro Ile Arg Ser Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Xaa Xaa 
        115             


<210>  15
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (117)..(118)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Thr Thr Ser Gly Asp Thr Thr Tyr Tyr Ala Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Arg Gly Gly Gly Val Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Xaa Xaa 
        115             


<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (120)..(121)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Phe Ser Ile Ser 
            20                  25                  30          


Ile Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Thr Thr Ser Ser Gly Thr Thr Asn Tyr Val Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His 
                85                  90                  95      


Ala Tyr Ile Ala Thr Thr Thr Asp Arg Gly Tyr Arg Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Xaa Xaa 
        115                 120     


<210>  17
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (123)..(124)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Tyr Asn 
            20                  25                  30          


Val Val Gly Trp Tyr Arg Gln Leu Ser Gly Asn Glu Arg Gly Gly Arg 
        35                  40                  45              


Thr Met Val Ala Gln Ile Asn Ala Tyr Gly Asp Thr Asn Tyr Ala Asn 
    50                  55                  60                  


Ala Val Val Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu His Met Ser Asn Leu Lys Pro Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Asn Gly Gln Arg Met Leu Glu Asn Tyr Thr Tyr Arg Asp Gln 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Gln Val Thr Val Xaa Xaa 
        115                 120                 


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (115)..(116)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Lys Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Xaa Xaa 
        115     


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (119)..(120)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Ser Val Gln Val Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Asn Ile Asp 
            20                  25                  30          


His Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Gly Val Ile Ser Ser Gly Ala Gly Pro Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Asn Cys Asn 
                85                  90                  95      


Ala Trp Ile Asp Tyr Gly Ser Gly Leu Pro Gln Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Xaa Xaa 
        115                 120 


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (115)..(116)
<223>  Xaa can be any naturally occurring amino acid

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            20                  25                  30          


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        35                  40                  45              


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    50                  55                  60                  


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                85                  90                  95      


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Xaa Xaa 
        115     


<210>  21
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - anti-CD33 VHH sequence


<220>
<221>  misc_feature
<222>  (119)..(120)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Leu Asn Ile Asp 
            20                  25                  30          


His Ile Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        35                  40                  45              


Gly Val Ile Ser Ser Gly Ala Gly Pro Asn Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Trp Ile Asp Tyr Gly Ser Gly Leu Pro Gln Asn Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Xaa Xaa 
        115                 120 


<210>  22
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  22

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            580                 585                 590         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        595                 600                 605             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    610                 615                 620                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
625                 630                 635                 640 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                645                 650                 655     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            660                 665                 670         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        675                 680                 685             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    690                 695                 700                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
705                 710                 715                 720 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                725                 730                 735     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            740                 745                 750         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        755                 760                 765             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    770                 775                 780     


<210>  23
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Phe Ser Leu Phe Ile Val Cys Thr Val Thr Leu Thr Leu Phe Leu 
            580                 585                 590         


Met Thr Ile Leu Thr Val Thr Lys Phe Arg Gly Phe Cys Phe Ile Cys 
        595                 600                 605             


Tyr Lys Thr Ala Gln Arg Leu Val Phe Lys Asp His Pro Gln Gly Thr 
    610                 615                 620                 


Glu Pro Asp Met Tyr Lys Tyr Asp Ala Tyr Leu Cys Phe Ser Ser Lys 
625                 630                 635                 640 


Asp Phe Thr Trp Val Gln Asn Ala Leu Leu Lys His Leu Asp Thr Gln 
                645                 650                 655     


Tyr Ser Asp Gln Asn Arg Phe Asn Leu Cys Phe Glu Glu Arg Asp Phe 
            660                 665                 670         


Val Pro Gly Glu Asn Arg Ile Ala Asn Ile Gln Asp Ala Ile Trp Asn 
        675                 680                 685             


Ser Arg Lys Ile Val Cys Leu Val Ser Arg His Phe Leu Arg Asp Gly 
    690                 695                 700                 


Trp Cys Leu Glu Ala Phe Ser Tyr Ala Gln Gly Arg Cys Leu Ser Asp 
705                 710                 715                 720 


Leu Asn Ser Ala Leu Ile Met Val Val Val Gly Ser Leu Ser Gln Tyr 
                725                 730                 735     


Gln Leu Met Lys His Gln Ser Ile Arg Gly Phe Val Gln Lys Gln Gln 
            740                 745                 750         


Tyr Leu Arg Trp Pro Glu Asp Leu Gln Asp Val Gly Trp Phe Leu His 
        755                 760                 765             


Lys Leu Ser Gln Gln Ile Leu Lys Lys Glu Lys Glu Lys Lys Lys Asp 
    770                 775                 780                 


Asn Asn Ile Pro Leu Gln Thr Val Ala Thr Ile Ser 
785                 790                 795     


<210>  24
<211>  785
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  24

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Thr Ile Ile Gly Val Ser Val Leu Ser Val Leu Val Val Ser Val 
            580                 585                 590         


Val Ala Val Leu Val Tyr Lys Phe Tyr Phe His Leu Met Leu Leu Ala 
        595                 600                 605             


Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn Ile Tyr Asp Ala Phe Val 
    610                 615                 620                 


Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val Arg Asn Glu Leu Val Lys 
625                 630                 635                 640 


Asn Leu Glu Glu Gly Val Pro Pro Phe Gln Leu Cys Leu His Tyr Arg 
                645                 650                 655     


Asp Phe Ile Pro Gly Val Ala Ile Ala Ala Asn Ile Ile His Glu Gly 
            660                 665                 670         


Phe His Lys Ser Arg Lys Val Ile Val Val Val Ser Gln His Phe Ile 
        675                 680                 685             


Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu Ile Ala Gln Thr Trp Gln 
    690                 695                 700                 


Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe Ile Val Leu Gln Lys Val 
705                 710                 715                 720 


Glu Lys Thr Leu Leu Arg Gln Gln Val Glu Leu Tyr Arg Leu Leu Ser 
                725                 730                 735     


Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser Val Leu Gly Arg His Ile 
            740                 745                 750         


Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu Asp Gly Lys Ser Trp Asn 
        755                 760                 765             


Pro Glu Gly Thr Val Gly Thr Gly Cys Asn Trp Gln Glu Ala Thr Ser 
    770                 775                 780                 


Ile 
785 


<210>  25
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Ala Leu Val Ser Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu 
            580                 585                 590         


Leu Thr Gly Val Leu Cys His Arg Phe His Gly Leu Trp Tyr Met Lys 
        595                 600                 605             


Met Met Trp Ala Trp Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro 
    610                 615                 620                 


Ser Arg Asn Ile Cys Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp 
625                 630                 635                 640 


Ala Tyr Trp Val Glu Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn 
                645                 650                 655     


Pro Pro Phe Lys Leu Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys 
            660                 665                 670         


Trp Ile Ile Asp Asn Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr 
        675                 680                 685             


Val Phe Val Leu Ser Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr 
    690                 695                 700                 


Glu Leu Asp Phe Ser His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala 
705                 710                 715                 720 


Ala Ile Leu Ile Leu Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln 
                725                 730                 735     


Arg Phe Cys Lys Leu Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu 
            740                 745                 750         


Trp Pro Met Asp Glu Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg 
        755                 760                 765             


Ala Ala Ile Lys Ser 
    770             


<210>  26
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  26

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Ile Tyr Ala Gly Val Cys Ile Ser Val Leu Val Leu Leu Ala Leu 
            580                 585                 590         


Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe Phe Lys Lys Glu Val Gln 
        595                 600                 605             


Gln Leu Ser Val Ser Phe Ser Ser Leu Gln Ile Lys Ala Leu Gln Asn 
    610                 615                 620                 


Ala Val Glu Lys Glu Val Gln Ala Glu Asp Asn Ile Tyr Ile Glu Asn 
625                 630                 635                 640 


Ser Leu Tyr Ala Thr Asp 
                645     


<210>  27
<211>  683
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  27

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Ile Leu Phe Met Val Ser Gly Ile Cys Ile Val Phe Gly Phe Ile 
            580                 585                 590         


Ile Leu Leu Leu Leu Val Leu Arg Lys Arg Arg Asp Ser Leu Ser Leu 
        595                 600                 605             


Ser Thr Gln Arg Thr Gln Gly Pro Ala Glu Ser Ala Arg Asn Leu Glu 
    610                 615                 620                 


Tyr Val Ser Val Ser Pro Thr Asn Asn Thr Val Tyr Ala Ser Val Thr 
625                 630                 635                 640 


His Ser Asn Arg Glu Thr Glu Ile Trp Thr Pro Arg Glu Asn Asp Thr 
                645                 650                 655     


Ile Thr Ile Tyr Ser Thr Ile Asn His Ser Lys Glu Ser Lys Pro Thr 
            660                 665                 670         


Phe Ser Arg Ala Thr Ala Leu Asp Asn Val Val 
        675                 680             


<210>  28
<211>  697
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  28

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Leu Leu Ser Val Leu Ala Met Phe Phe Leu Leu Val Leu Ile Leu 
            580                 585                 590         


Ser Ser Val Phe Leu Phe Arg Leu Phe Lys Arg Arg Gln Gly Arg Ile 
        595                 600                 605             


Phe Pro Glu Gly Ser Cys Leu Asn Thr Phe Thr Lys Asn Pro Tyr Ala 
    610                 615                 620                 


Ala Ser Lys Lys Thr Ile Tyr Thr Tyr Ile Met Ala Ser Arg Asn Thr 
625                 630                 635                 640 


Gln Pro Ala Glu Ser Arg Ile Tyr Asp Glu Ile Leu Gln Ser Lys Val 
                645                 650                 655     


Leu Pro Ser Lys Glu Glu Pro Val Asn Thr Val Tyr Ser Glu Val Gln 
            660                 665                 670         


Phe Ala Asp Lys Met Gly Lys Ala Ser Thr Gln Asp Ser Lys Pro Pro 
        675                 680                 685             


Gly Thr Ser Ser Tyr Glu Ile Val Ile 
    690                 695         


<210>  29
<211>  698
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  29

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Pro Trp Ala Val Tyr Ala Gly Leu Leu Gly Gly Val Ile Met Ile 
            580                 585                 590         


Leu Ile Met Val Val Ile Leu Gln Leu Arg Arg Arg Ala Thr Leu Thr 
        595                 600                 605             


Thr Thr Asn Gln Tyr Trp Ser Gln Asn Val Leu Thr Gln Asp Gln Glu 
    610                 615                 620                 


Arg Cys Pro Gly Cys Leu Pro Met Val Lys Arg Thr Ile Thr Arg Gln 
625                 630                 635                 640 


Gln Trp Lys Lys Lys Ala Leu Arg Ser Met Pro Lys Ser Arg Asn Gln 
                645                 650                 655     


Val Leu Phe Arg Arg Asn Leu Thr Pro Ser Gln Leu Arg Thr Leu Ala 
            660                 665                 670         


Pro Pro Tyr Met Leu Leu Pro Gln Ser Leu Ser Gln Ser Leu Ser Arg 
        675                 680                 685             


Lys Gln Ile Pro Ser Gln Ser Met Leu Val 
    690                 695             


<210>  30
<211>  640
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  30

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Val Ala Ala Ile Leu Gly Leu Gly Leu Val Leu Gly Leu Leu Gly 
            580                 585                 590         


Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu Arg Arg Asp Gln Arg 
        595                 600                 605             


Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr 
    610                 615                 620                 


Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
625                 630                 635                 640 


<210>  31
<211>  835
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  31

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Ile Leu Val Pro Cys Val Leu Gly Leu Leu Leu Leu Pro Ile Leu 
            580                 585                 590         


Ala Met Leu Met Ala Leu Cys Val His Cys His Arg Leu Pro Gly Ser 
        595                 600                 605             


Tyr Asp Ser Thr Ser Ser Asp Ser Leu Tyr Pro Arg Gly Ile Gln Phe 
    610                 615                 620                 


Lys Arg Pro His Thr Val Ala Pro Trp Pro Pro Ala Tyr Pro Pro Val 
625                 630                 635                 640 


Thr Ser Tyr Pro Pro Leu Ser Gln Pro Asp Leu Leu Pro Ile Pro Arg 
                645                 650                 655     


Ser Pro Gln Pro Leu Gly Gly Ser His Arg Thr Pro Ser Ser Arg Arg 
            660                 665                 670         


Asp Ser Asp Gly Ala Asn Ser Val Ala Ser Tyr Glu Asn Glu Gly Ala 
        675                 680                 685             


Ser Gly Ile Arg Gly Ala Gln Ala Gly Trp Gly Val Trp Gly Pro Ser 
    690                 695                 700                 


Trp Thr Arg Leu Thr Pro Val Ser Leu Pro Pro Glu Pro Ala Cys Glu 
705                 710                 715                 720 


Asp Ala Asp Glu Asp Glu Asp Asp Tyr His Asn Pro Gly Tyr Leu Val 
                725                 730                 735     


Val Leu Pro Asp Ser Thr Pro Ala Thr Ser Thr Ala Ala Pro Ser Ala 
            740                 745                 750         


Pro Ala Leu Ser Thr Pro Gly Ile Arg Asp Ser Ala Phe Ser Met Glu 
        755                 760                 765             


Ser Ile Asp Asp Tyr Val Asn Val Pro Glu Ser Gly Glu Ser Ala Glu 
    770                 775                 780                 


Ala Ser Leu Asp Gly Ser Arg Glu Tyr Val Asn Val Ser Gln Glu Leu 
785                 790                 795                 800 


His Pro Gly Ala Ala Lys Thr Glu Pro Ala Ala Leu Ser Ser Gln Glu 
                805                 810                 815     


Ala Glu Glu Val Glu Glu Glu Gly Ala Pro Asp Tyr Glu Asn Leu Gln 
            820                 825                 830         


Glu Leu Asn 
        835 


<210>  32
<211>  636
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  32

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile 
            580                 585                 590         


Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser 
        595                 600                 605             


Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn 
    610                 615                 620                 


Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr Leu 
625                 630                 635     


<210>  33
<211>  658
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Trp Trp Phe Leu Ser Gly Ser Leu Val Ile Val Ile Val Cys Ser 
            580                 585                 590         


Thr Val Gly Leu Ile Ile Cys Val Lys Arg Arg Lys Pro Arg Gly Asp 
        595                 600                 605             


Val Val Lys Val Ile Val Ser Val Gln Arg Lys Arg Gln Glu Ala Glu 
    610                 615                 620                 


Gly Glu Ala Thr Val Ile Glu Ala Leu Gln Ala Pro Pro Asp Val Thr 
625                 630                 635                 640 


Thr Val Ala Val Glu Glu Thr Ile Pro Ser Phe Thr Gly Arg Ser Pro 
                645                 650                 655     


Asn His 
        


<210>  34
<211>  799
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  34

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Gly Arg Val Gly Val Phe Trp Val Gln Val Leu Leu Ala Gly Leu 
            580                 585                 590         


Val Val Pro Leu Leu Leu Gly Ala Thr Leu Thr Tyr Thr Tyr Arg His 
        595                 600                 605             


Cys Trp Pro His Lys Pro Leu Val Thr Ala Asp Glu Ala Gly Met Glu 
    610                 615                 620                 


Ala Leu Thr Pro Pro Pro Ala Thr His Leu Ser Pro Leu Asp Ser Ala 
625                 630                 635                 640 


His Thr Leu Leu Ala Pro Pro Asp Ser Ser Glu Lys Ile Cys Thr Val 
                645                 650                 655     


Gln Leu Val Gly Asn Ser Trp Thr Pro Gly Tyr Pro Glu Thr Gln Glu 
            660                 665                 670         


Ala Leu Cys Pro Gln Val Thr Trp Ser Trp Asp Gln Leu Pro Ser Arg 
        675                 680                 685             


Ala Leu Gly Pro Ala Ala Ala Pro Thr Leu Ser Pro Glu Ser Pro Ala 
    690                 695                 700                 


Gly Ser Pro Ala Met Met Leu Gln Pro Gly Pro Gln Leu Tyr Asp Val 
705                 710                 715                 720 


Met Asp Ala Val Pro Ala Arg Arg Trp Lys Glu Phe Val Arg Thr Leu 
                725                 730                 735     


Gly Leu Arg Glu Ala Glu Ile Glu Ala Val Glu Val Glu Ile Gly Arg 
            740                 745                 750         


Phe Arg Asp Gln Gln Tyr Glu Met Leu Lys Arg Trp Arg Gln Gln Gln 
        755                 760                 765             


Pro Ala Gly Leu Gly Ala Val Tyr Ala Ala Leu Glu Arg Met Gly Leu 
    770                 775                 780                 


Asp Gly Cys Val Glu Asp Leu Arg Ser Arg Leu Gln Arg Gly Pro 
785                 790                 795                 


<210>  35
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Phe Leu Val Ile Ile Val Ile Leu Ser Ala Leu Phe Leu Gly Thr 
            580                 585                 590         


Leu Ala Cys Phe Cys Val Trp Arg Arg Lys Arg Lys Glu Lys Gln Ser 
        595                 600                 605             


Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile Tyr Glu Asp Val Lys Asp 
    610                 615                 620                 


Leu Lys Thr Arg Arg Asn His Glu Gln Glu Gln Thr Phe Pro Gly Gly 
625                 630                 635                 640 


Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser Gln Ser Ser Ala Pro Thr 
                645                 650                 655     


Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser Leu Ile Gln Pro Ser Arg 
            660                 665                 670         


Lys Ser Gly Ser Arg Lys Arg Asn His Ser Pro Ser Phe Asn Ser Thr 
        675                 680                 685             


Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro Lys Ala Gln Asn Pro Ala 
    690                 695                 700                 


Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe Asp Val Tyr Ser 
705                 710                 715             


<210>  36
<211>  661
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  36

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Ala Leu Val Val Ile Pro Ile Ile Phe Gly Ile Leu Phe Ala Ile 
            580                 585                 590         


Leu Leu Val Leu Val Phe Ile Lys Lys Val Ala Lys Lys Pro Thr Asn 
        595                 600                 605             


Lys Ala Pro His Pro Lys Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp 
    610                 615                 620                 


Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro Val Gln Glu Thr Leu His 
625                 630                 635                 640 


Gly Cys Gln Pro Val Thr Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser 
                645                 650                 655     


Val Gln Glu Arg Gln 
            660     


<210>  37
<211>  787
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Pro Val Leu Phe Trp Val Ile Leu Val Leu Val Val Val Val Gly 
            580                 585                 590         


Ser Ser Ala Phe Leu Leu Cys His Arg Arg Ala Cys Arg Lys Arg Ile 
        595                 600                 605             


Arg Gln Lys Leu His Leu Cys Tyr Pro Val Gln Thr Ser Gln Pro Lys 
    610                 615                 620                 


Leu Glu Leu Val Asp Ser Arg Pro Arg Arg Ser Ser Thr Gln Leu Arg 
625                 630                 635                 640 


Ser Gly Ala Ser Val Thr Glu Pro Val Ala Glu Glu Arg Gly Leu Met 
                645                 650                 655     


Ser Gln Pro Leu Met Glu Thr Cys His Ser Val Gly Ala Ala Tyr Leu 
            660                 665                 670         


Glu Ser Leu Pro Leu Gln Asp Ala Ser Pro Ala Gly Gly Pro Ser Ser 
        675                 680                 685             


Pro Arg Asp Leu Pro Glu Pro Arg Val Ser Thr Glu His Thr Asn Asn 
    690                 695                 700                 


Lys Ile Glu Lys Ile Tyr Ile Met Lys Ala Asp Thr Val Ile Val Gly 
705                 710                 715                 720 


Thr Val Lys Ala Glu Leu Pro Glu Gly Arg Gly Leu Ala Gly Pro Ala 
                725                 730                 735     


Glu Pro Glu Leu Glu Glu Glu Leu Glu Ala Asp His Thr Pro His Tyr 
            740                 745                 750         


Pro Glu Gln Glu Thr Glu Pro Pro Leu Gly Ser Cys Ser Asp Val Met 
        755                 760                 765             


Leu Ser Val Glu Glu Glu Gly Lys Glu Asp Pro Leu Pro Thr Ala Ala 
    770                 775                 780                 


Ser Gly Lys 
785         


<210>  38
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            580                 585                 590         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        595                 600                 605             


Ser Arg Leu Leu His Ser Asp Tyr Met Phe Met Thr Pro Arg Arg Pro 
    610                 615                 620                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
625                 630                 635                 640 


Ala Ala Tyr Arg Ser 
                645 


<210>  39
<211>  645
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser 
            580                 585                 590         


Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys Arg 
        595                 600                 605             


Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro 
    610                 615                 620                 


Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe 
625                 630                 635                 640 


Ala Ala Tyr Arg Ser 
                645 


<210>  40
<211>  709
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  40

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Phe Leu Phe Val Leu Leu Gly Val Gly Ser Met Gly Val Ala Ala 
            580                 585                 590         


Ile Val Trp Gly Ala Trp Phe Trp Gly Arg Arg Ser Cys Gln Gln Arg 
        595                 600                 605             


Asp Ser Gly Asn Ser Pro Gly Asn Ala Phe Tyr Ser Asn Val Leu Tyr 
    610                 615                 620                 


Arg Pro Arg Gly Ala Pro Lys Lys Ser Glu Asp Cys Ser Gly Glu Gly 
625                 630                 635                 640 


Lys Asp Gln Arg Gly Gln Ser Ile Tyr Ser Thr Ser Phe Pro Gln Pro 
                645                 650                 655     


Ala Pro Arg Gln Pro His Leu Ala Ser Arg Pro Cys Pro Ser Pro Arg 
            660                 665                 670         


Pro Cys Pro Ser Pro Arg Pro Gly His Pro Val Ser Met Val Arg Val 
        675                 680                 685             


Ser Pro Arg Pro Ser Pro Thr Gln Gln Pro Arg Pro Lys Gly Phe Pro 
    690                 695                 700                 


Lys Val Gly Glu Glu 
705                 


<210>  41
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala 
            580                 585                 590         


Gly Ala Leu Phe Leu His Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly 
        595                 600                 605             


Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg 
    610                 615                 620                 


Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro 
625                 630                 635                 640 


Glu Pro Ala Cys Ser Pro 
                645     


<210>  42
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  42

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
            580                 585                 590         


Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg 
        595                 600                 605             


Gln Lys Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His 
    610                 615                 620                 


Leu Pro Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His 
625                 630                 635                 640 


Leu Leu Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser 
                645                 650                 655     


Ala Ser Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala 
            660                 665                 670         


Pro Gly Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly 
        675                 680                 685             


Ser Ser Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr 
    690                 695                 700                 


Cys Ile Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser 
705                 710                 715                 720 


Ser Gln Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu 
                725                 730                 735     


Ser Pro Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe 
            740                 745                 750         


Arg Ser Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu 
        755                 760                 765             


Lys Pro Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    770                 775                 780             


<210>  43
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
            580                 585                 590         


Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg 
        595                 600                 605             


Gln 
    


<210>  44
<211>  843
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  44

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
            580                 585                 590         


Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg 
        595                 600                 605             


Gln Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser 
    610                 615                 620                 


Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg 
625                 630                 635                 640 


Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp 
                645                 650                 655     


Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln 
            660                 665                 670         


Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln 
        675                 680                 685             


Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys 
    690                 695                 700                 


Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu 
705                 710                 715                 720 


Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys 
                725                 730                 735     


Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu 
            740                 745                 750         


Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu 
        755                 760                 765             


Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Lys Lys Val 
    770                 775                 780                 


Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys Gln Glu Pro Gln 
785                 790                 795                 800 


Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn Thr Ala Ala Pro 
                805                 810                 815     


Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr Gln Glu Asp Gly 
            820                 825                 830         


Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
        835                 840             


<210>  45
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  45

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
            580                 585                 590         


Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg 
        595                 600                 605             


Gln Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser 
    610                 615                 620                 


Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg 
625                 630                 635                 640 


Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp 
                645                 650                 655     


Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln 
            660                 665                 670         


Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln 
        675                 680                 685             


Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys 
    690                 695                 700                 


Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu 
705                 710                 715                 720 


Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys 
                725                 730                 735     


Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu 
            740                 745                 750         


Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu 
        755                 760                 765             


Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile 
    770                 775                 780     


<210>  46
<211>  671
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  46

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
            580                 585                 590         


Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg 
        595                 600                 605             


Gln Lys Lys Val Ala Lys Lys Pro Thr Asn Lys Ala Pro His Pro Lys 
    610                 615                 620                 


Gln Glu Pro Gln Glu Ile Asn Phe Pro Asp Asp Leu Pro Gly Ser Asn 
625                 630                 635                 640 


Thr Ala Ala Pro Val Gln Glu Thr Leu His Gly Cys Gln Pro Val Thr 
                645                 650                 655     


Gln Glu Asp Gly Lys Glu Ser Arg Ile Ser Val Gln Glu Arg Gln 
            660                 665                 670     


<210>  47
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  47

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
            580                 585                 590         


Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg 
        595                 600                 605             


Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys 
    610                 615                 620                 


Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
625                 630                 635                 


<210>  48
<211>  719
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  48

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Ile Tyr Leu Ile Ile Gly Ile Cys Gly Gly Gly Ser Leu Leu Met 
            580                 585                 590         


Val Phe Val Ala Leu Leu Val Phe Tyr Ile Thr Lys Arg Lys Lys Gln 
        595                 600                 605             


Arg Ser Arg Arg Asn Asp Glu Glu Leu Glu Thr Arg Ala His Arg Val 
    610                 615                 620                 


Ala Thr Glu Glu Arg Gly Arg Lys Pro His Gln Ile Pro Ala Ser Thr 
625                 630                 635                 640 


Pro Gln Asn Pro Ala Thr Ser Gln His Pro Pro Pro Pro Pro Gly His 
                645                 650                 655     


Arg Ser Gln Ala Pro Ser His Arg Pro Pro Pro Pro Gly His Arg Val 
            660                 665                 670         


Gln His Gln Pro Gln Lys Arg Pro Pro Ala Pro Ser Gly Thr Gln Val 
        675                 680                 685             


His Gln Gln Lys Gly Pro Pro Leu Pro Arg Pro Arg Val Gln Pro Lys 
    690                 695                 700                 


Pro Pro His Gly Ala Ala Glu Asn Ser Leu Ser Pro Ser Ser Asn 
705                 710                 715                 


<210>  49
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  49

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
465                 470                 475                 480 


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
                485                 490                 495     


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Gly Val Gln Val Glu Thr 
            500                 505                 510         


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
        515                 520                 525             


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
    530                 535                 540                 


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
545                 550                 555                 560 


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
                565                 570                 575     


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
            580                 585                 590         


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
        595                 600                 605             


Leu Leu Lys Leu Glu Gly Gly Arg Phe Trp Val Leu Val Val Val Gly 
    610                 615                 620                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
625                 630                 635                 640 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                645                 650                 655     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            660                 665                 670         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        675                 680                 


<210>  50
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  50

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
            580                 585                 590         


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
        595                 600                 605             


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
    610                 615                 620                 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
625                 630                 635                 640 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
                645                 650                 655     


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
            660                 665                 670         


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        675                 680                 


<210>  51
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  51

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Met Ala 
                565                 570                 575     


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
            580                 585                 590         


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
        595                 600                 605     


<210>  52
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  52

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Ser Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
            580                 585                 590         


Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg 
        595                 600                 605             


Gln 
    


<210>  53
<211>  609
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  53

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly 
                565                 570                 575     


Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe 
            580                 585                 590         


Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg 
        595                 600                 605             


Gln 
    


<210>  54
<211>  628
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  54

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Lys Gly 
                565                 570                 575     


Lys His Leu Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe 
            580                 585                 590         


Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu 
        595                 600                 605             


Val Thr Val Ala Phe Ile Ile Phe Trp Val Cys Val Arg Cys Arg His 
    610                 615                 620                 


Arg Arg Arg Gln 
625             


<210>  55
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  55

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Ser 
                565                 570                 575     


Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
            580                 585                 590         


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Cys Val Arg Cys Arg 
        595                 600                 605             


His Arg Arg Arg Gln 
    610             


<210>  56
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  56

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Ser Asn 
                565                 570                 575     


Ile Lys Val Leu Pro Thr Trp Ser Thr Pro Val Gln Pro Met Ala Leu 
            580                 585                 590         


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
        595                 600                 605             


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
    610                 615                 620     


<210>  57
<211>  619
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  57

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly 
385                 390                 395                 400 


Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg 
                405                 410                 415     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
            420                 425                 430         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu 
        435                 440                 445             


Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg 
465                 470                 475                 480 


Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met 
                485                 490                 495     


Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro 
            500                 505                 510         


Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu 
        515                 520                 525             


Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser 
    530                 535                 540                 


Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro 
545                 550                 555                 560 


His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Pro 
                565                 570                 575     


Pro Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val 
            580                 585                 590         


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
        595                 600                 605             


Val Cys Val Arg Cys Arg His Arg Arg Arg Gln 
    610                 615                 


<210>  58
<211>  606
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  58

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Gly Ser Phe Trp Val Leu Val Val Val Gly Gly Val 
        115                 120                 125             


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
    130                 135                 140                 


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
145                 150                 155                 160 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                165                 170                 175     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            180                 185                 190         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        195                 200                 205             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    210                 215                 220                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
225                 230                 235                 240 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                245                 250                 255     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            260                 265                 270         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        275                 280                 285             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser Gly Ala 
    290                 295                 300                 


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
305                 310                 315                 320 


Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu 
                325                 330                 335     


Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly 
            340                 345                 350         


Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        355                 360                 365             


Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly 
    370                 375                 380                 


Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn 
385                 390                 395                 400 


Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala 
                405                 410                 415     


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            420                 425                 430         


Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala 
        435                 440                 445             


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
465                 470                 475                 480 


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
                485                 490                 495     


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
            500                 505                 510         


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
        515                 520                 525             


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
    530                 535                 540                 


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
545                 550                 555                 560 


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
                565                 570                 575     


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
            580                 585                 590         


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
        595                 600                 605     


<210>  59
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  59

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr 
        115                 120                 125             


Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala 
    130                 135                 140                 


Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys 
145                 150                 155                 160 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                165                 170                 175     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            180                 185                 190         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        195                 200                 205             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    210                 215                 220                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
225                 230                 235                 240 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                245                 250                 255     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            260                 265                 270         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        275                 280                 285             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    290                 295                 300                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser Gly Ala Thr 
305                 310                 315                 320 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                325                 330                 335     


Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp 
            340                 345                 350         


Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        355                 360                 365             


Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg 
    370                 375                 380                 


Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
385                 390                 395                 400 


Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr 
                405                 410                 415     


Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys 
            420                 425                 430         


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
        435                 440                 445             


Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp 
    450                 455                 460                 


Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
                485                 490                 495     


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
            500                 505                 510         


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
        515                 520                 525             


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
    530                 535                 540                 


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
545                 550                 555                 560 


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
                565                 570                 575     


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu 
            580                 585                 590         


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
        595                 600                 605             


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
    610                 615                 620     


<210>  60
<211>  621
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  60

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Lys Gly Lys His Leu Cys Pro Ser Pro Leu Phe Pro 
        115                 120                 125             


Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu 
    130                 135                 140                 


Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
145                 150                 155                 160 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                165                 170                 175     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            180                 185                 190         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg 
        195                 200                 205             


Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn 
    210                 215                 220                 


Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg 
225                 230                 235                 240 


Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro 
                245                 250                 255     


Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
            260                 265                 270         


Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His 
        275                 280                 285             


Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp 
    290                 295                 300                 


Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser Gly Ala Thr 
305                 310                 315                 320 


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
                325                 330                 335     


Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp 
            340                 345                 350         


Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
        355                 360                 365             


Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg 
    370                 375                 380                 


Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
385                 390                 395                 400 


Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr 
                405                 410                 415     


Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys 
            420                 425                 430         


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
        435                 440                 445             


Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp 
    450                 455                 460                 


Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
                485                 490                 495     


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
            500                 505                 510         


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
        515                 520                 525             


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
    530                 535                 540                 


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
545                 550                 555                 560 


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
                565                 570                 575     


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu 
            580                 585                 590         


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
        595                 600                 605             


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
    610                 615                 620     


<210>  61
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  61

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Gly Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu 
        115                 120                 125             


Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val 
    130                 135                 140                 


Ala Phe Ile Ile Phe Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
145                 150                 155                 160 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                165                 170                 175     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            180                 185                 190         


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
        195                 200                 205             


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
    210                 215                 220                 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
225                 230                 235                 240 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
                245                 250                 255     


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
            260                 265                 270         


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
        275                 280                 285             


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
    290                 295                 300                 


Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
305                 310                 315                 320 


Asp Val Glu Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu 
                325                 330                 335     


Leu Phe Leu Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln 
            340                 345                 350         


Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg 
        355                 360                 365             


Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp 
    370                 375                 380                 


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser 
385                 390                 395                 400 


Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr 
                405                 410                 415     


Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
            420                 425                 430         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe 
        435                 440                 445             


Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
465                 470                 475                 480 


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
                485                 490                 495     


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
            500                 505                 510         


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
        515                 520                 525             


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
    530                 535                 540                 


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
545                 550                 555                 560 


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
                565                 570                 575     


Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
            580                 585                 590         


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
        595                 600                 605             


Arg Arg Arg Gln 
    610         


<210>  62
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  62

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Arg Val Lys 
    290                 295                 300                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
305                 310                 315                 320 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                325                 330                 335     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            340                 345                 350         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        355                 360                 365             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    370                 375                 380                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
385                 390                 395                 400 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
                405                 410                 415     


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
            420                 425                 430         


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
        435                 440                 445             


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
    450                 455                 460                 


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
465                 470                 475                 480 


Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala 
                485                 490                 495     


Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp 
            500                 505                 510         


Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp 
        515                 520                 525             


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
    530                 535                 540                 


Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val 
545                 550                 555                 560 


Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
            580                 585                 590         


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
        595                 600                 605             


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
    610                 615                 620                 


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
625                 630                 635                 640 


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
                645                 650                 655     


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
            660                 665                 670         


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg 
        675                 680                 685             


Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
    690                 695                 700                 


Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
705                 710                 715                 720 


<210>  63
<211>  720
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  63

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
145                 150                 155                 160 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                165                 170                 175     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            180                 185                 190         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        195                 200                 205             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    210                 215                 220                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
225                 230                 235                 240 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                245                 250                 255     


Pro Pro Arg Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
            260                 265                 270         


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
        275                 280                 285             


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
    290                 295                 300                 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
305                 310                 315                 320 


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
                325                 330                 335     


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
            340                 345                 350         


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
        355                 360                 365             


Pro Pro Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
    370                 375                 380                 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Ser Met Glu Thr Asp Thr 
385                 390                 395                 400 


Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Glu 
                405                 410                 415     


Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser 
            420                 425                 430         


Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met 
        435                 440                 445             


Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu 
    450                 455                 460                 


Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg 
465                 470                 475                 480 


Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                485                 490                 495     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His 
            500                 505                 510         


Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr 
        515                 520                 525             


Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser 
    530                 535                 540                 


Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val 
545                 550                 555                 560 


His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg 
                565                 570                 575     


Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile 
            580                 585                 590         


Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala 
        595                 600                 605             


Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro 
    610                 615                 620                 


Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu 
625                 630                 635                 640 


Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala 
                645                 650                 655     


Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys 
            660                 665                 670         


Arg His Arg Arg Arg Gln Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        675                 680                 685             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    690                 695                 700                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
705                 710                 715                 720 


<210>  64
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  64

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala 
    370                 375                 380                 


Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp 
385                 390                 395                 400 


Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp 
                405                 410                 415     


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
            420                 425                 430         


Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val 
        435                 440                 445             


Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
465                 470                 475                 480 


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
                485                 490                 495     


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
            500                 505                 510         


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
        515                 520                 525             


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
    530                 535                 540                 


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
545                 550                 555                 560 


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg 
                565                 570                 575     


Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
            580                 585                 590         


Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
        595                 600                 605             


<210>  65
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  65

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
465                 470                 475                 480 


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
                485                 490                 495     


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
            500                 505                 510         


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
        515                 520                 525             


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
    530                 535                 540                 


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
545                 550                 555                 560 


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
                565                 570                 575     


Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
            580                 585                 590         


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
        595                 600                 605             


Arg Arg Arg Gln 
    610         


<210>  66
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - DARIC fusion polypeptide

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr 
465                 470                 475                 480 


Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu 
                485                 490                 495     


Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe 
            500                 505                 510         


Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly 
        515                 520                 525             


Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro 
    530                 535                 540                 


Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His 
545                 550                 555                 560 


Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg 
                565                 570                 575     


Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
            580                 585                 590         


Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
        595                 600                 605             


<210>  67
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
                485                 490                 495     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            500                 505                 510         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        515                 520                 525             


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    530                 535                 540                 


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
545                 550                 555                 560 


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                565                 570                 575     


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            580                 585                 590         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        595                 600                 605             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    610                 615                 620                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
625                 630                 635                 640 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                645                 650                 655     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            660                 665                 670         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        675                 680                 685             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    690                 695                 700                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
705                 710                 715                 720 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                725                 730                 735     


Cys Arg His Arg Arg Arg Gln 
            740             


<210>  68
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
465                 470                 475                 480 


Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                485                 490                 495     


Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr 
            500                 505                 510         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly 
        515                 520                 525             


Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val 
    530                 535                 540                 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
545                 550                 555                 560 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu 
                565                 570                 575     


Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
        595                 600                 605             


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
    610                 615                 620                 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
625                 630                 635                 640 


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
                645                 650                 655     


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
            660                 665                 670         


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
        675                 680                 685             


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    690                 695                 700                 


Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
705                 710                 715                 720 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
                725                 730                 735     


Arg Arg Gln 
            


<210>  69
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly 
        435                 440                 445             


Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
465                 470                 475                 480 


Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg 
                485                 490                 495     


Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp 
            500                 505                 510         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser 
        515                 520                 525             


Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr 
    530                 535                 540                 


Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe 
                565                 570                 575     


Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
            580                 585                 590         


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
        595                 600                 605             


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
    610                 615                 620                 


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
625                 630                 635                 640 


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
                645                 650                 655     


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
            660                 665                 670         


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
        675                 680                 685             


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
    690                 695                 700                 


Glu Gly Gly Ser Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
705                 710                 715                 720 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
                725                 730                 735     


Arg Arg Arg Gln 
            740 


<210>  70
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  70

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu 
                325                 330                 335     


Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
465                 470                 475                 480 


Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                485                 490                 495     


Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr 
            500                 505                 510         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly 
        515                 520                 525             


Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val 
    530                 535                 540                 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
545                 550                 555                 560 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu 
                565                 570                 575     


Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
        595                 600                 605             


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
    610                 615                 620                 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
625                 630                 635                 640 


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
                645                 650                 655     


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
            660                 665                 670         


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
        675                 680                 685             


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    690                 695                 700                 


Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
705                 710                 715                 720 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
                725                 730                 735     


Arg Arg Gln 
            


<210>  71
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  71

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu 
                325                 330                 335     


Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly Arg 
        435                 440                 445             


Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly 
    450                 455                 460                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu 
465                 470                 475                 480 


Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                485                 490                 495     


Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr 
            500                 505                 510         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly 
        515                 520                 525             


Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val 
    530                 535                 540                 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
545                 550                 555                 560 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu 
                565                 570                 575     


Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro 
            580                 585                 590         


Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp 
        595                 600                 605             


Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr 
    610                 615                 620                 


Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn 
625                 630                 635                 640 


Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp 
                645                 650                 655     


Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr 
            660                 665                 670         


Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile 
        675                 680                 685             


Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu 
    690                 695                 700                 


Gly Gly Ser Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu 
705                 710                 715                 720 


Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg 
                725                 730                 735     


Arg Arg Gln 
            


<210>  72
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  72

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys 
        435                 440                 445             


Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
    450                 455                 460                 


Lys Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly 
                485                 490                 495     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp 
            500                 505                 510         


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
        515                 520                 525             


Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala 
    530                 535                 540                 


Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
545                 550                 555                 560 


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                565                 570                 575     


Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu 
            580                 585                 590         


Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr 
        595                 600                 605             


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
    610                 615                 620                 


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
625                 630                 635                 640 


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
                645                 650                 655     


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
            660                 665                 670         


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
        675                 680                 685             


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
    690                 695                 700                 


Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly 
705                 710                 715                 720 


Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val 
                725                 730                 735     


Arg Cys Arg His Arg Arg Arg Gln 
            740                 


<210>  73
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  73

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly 
        435                 440                 445             


Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
465                 470                 475                 480 


Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg 
                485                 490                 495     


Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp 
            500                 505                 510         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser 
        515                 520                 525             


Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr 
    530                 535                 540                 


Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe 
                565                 570                 575     


Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
            580                 585                 590         


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
        595                 600                 605             


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
    610                 615                 620                 


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
625                 630                 635                 640 


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
                645                 650                 655     


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
            660                 665                 670         


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
        675                 680                 685             


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
    690                 695                 700                 


Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
705                 710                 715                 720 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
                725                 730                 735     


Arg Arg Arg Gln 
            740 


<210>  74
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  74

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Leu Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Thr Asp Glu Trp Gly 
        435                 440                 445             


Arg Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
    450                 455                 460                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
465                 470                 475                 480 


Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg 
                485                 490                 495     


Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp 
            500                 505                 510         


Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser 
        515                 520                 525             


Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr 
    530                 535                 540                 


Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
545                 550                 555                 560 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe 
                565                 570                 575     


Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
            580                 585                 590         


Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly 
        595                 600                 605             


Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr 
    610                 615                 620                 


Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg 
625                 630                 635                 640 


Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly 
                645                 650                 655     


Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu 
            660                 665                 670         


Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile 
        675                 680                 685             


Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu 
    690                 695                 700                 


Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu 
705                 710                 715                 720 


Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His 
                725                 730                 735     


Arg Arg Arg Gln 
            740 


<210>  75
<211>  733
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  75

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
465                 470                 475                 480 


Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg 
                485                 490                 495     


Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
            500                 505                 510         


Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr 
        515                 520                 525             


Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys 
    530                 535                 540                 


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
545                 550                 555                 560 


Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp 
                565                 570                 575     


Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly 
            580                 585                 590         


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
        595                 600                 605             


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
    610                 615                 620                 


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
625                 630                 635                 640 


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
                645                 650                 655     


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
            660                 665                 670         


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
        675                 680                 685             


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu 
    690                 695                 700                 


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
705                 710                 715                 720 


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
                725                 730             


<210>  76
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  76

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
465                 470                 475                 480 


Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                485                 490                 495     


Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg 
            500                 505                 510         


Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val 
        515                 520                 525             


Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser 
    530                 535                 540                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
545                 550                 555                 560 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp 
                565                 570                 575     


Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
        595                 600                 605             


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
    610                 615                 620                 


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
625                 630                 635                 640 


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
                645                 650                 655     


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
            660                 665                 670         


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
        675                 680                 685             


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
    690                 695                 700                 


Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
705                 710                 715                 720 


Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg 
                725                 730                 735     


Arg Gln 
        


<210>  77
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  77

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
                485                 490                 495     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            500                 505                 510         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        515                 520                 525             


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    530                 535                 540                 


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
545                 550                 555                 560 


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                565                 570                 575     


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            580                 585                 590         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        595                 600                 605             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    610                 615                 620                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
625                 630                 635                 640 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                645                 650                 655     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            660                 665                 670         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        675                 680                 685             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    690                 695                 700                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
705                 710                 715                 720 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                725                 730                 735     


Cys Arg His Arg Arg Arg Gln 
            740             


<210>  78
<211>  748
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  78

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu 
                485                 490                 495     


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser 
            500                 505                 510         


Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
        515                 520                 525             


Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala 
    530                 535                 540                 


Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn 
545                 550                 555                 560 


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
                565                 570                 575     


Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly 
            580                 585                 590         


Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val 
        595                 600                 605             


Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg 
    610                 615                 620                 


Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys 
625                 630                 635                 640 


Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu 
                645                 650                 655     


Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met 
            660                 665                 670         


Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr 
        675                 680                 685             


Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val 
    690                 695                 700                 


Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile 
705                 710                 715                 720 


Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile 
                725                 730                 735     


Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
            740                 745             


<210>  79
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  79

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Met His Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
145                 150                 155                 160 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                165                 170                 175     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
            180                 185                 190         


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
        195                 200                 205             


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
    210                 215                 220                 


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
225                 230                 235                 240 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
                245                 250                 255     


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
            260                 265                 270         


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
        275                 280                 285             


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly Ser 
    290                 295                 300                 


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
305                 310                 315                 320 


Asn Pro Gly Pro Ser Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu 
                325                 330                 335     


Leu Leu Trp Val Pro Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser 
            340                 345                 350         


Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        355                 360                 365             


Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln 
    370                 375                 380                 


Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly 
385                 390                 395                 400 


Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
                405                 410                 415     


Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg 
            420                 425                 430         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala 
        435                 440                 445             


Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys 
    450                 455                 460                 


Pro Gly Gly Ser Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
465                 470                 475                 480 


Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                485                 490                 495     


Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly 
            500                 505                 510         


Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn 
        515                 520                 525             


Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala 
    530                 535                 540                 


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
545                 550                 555                 560 


Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala 
                565                 570                 575     


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        595                 600                 605             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    610                 615                 620                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
625                 630                 635                 640 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                645                 650                 655     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            660                 665                 670         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        675                 680                 685             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
    690                 695                 700                 


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
705                 710                 715                 720 


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
                725                 730                 


<210>  80
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  80

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Ile Leu Trp His Glu Met Trp His Glu 
            20                  25                  30          


Gly Leu Glu Glu Ala Ser Arg Leu Tyr Phe Gly Glu Arg Asn Val Lys 
        35                  40                  45              


Gly Met Phe Glu Val Leu Glu Pro Leu His Ala Met Met Glu Arg Gly 
    50                  55                  60                  


Pro Gln Thr Leu Lys Glu Thr Ser Phe Asn Gln Ala Tyr Gly Arg Asp 
65                  70                  75                  80  


Leu Met Glu Ala Gln Glu Trp Cys Arg Lys Tyr Met Lys Ser Gly Asn 
                85                  90                  95      


Val Lys Asp Leu Leu Gln Ala Trp Asp Leu Tyr Tyr His Val Phe Arg 
            100                 105                 110         


Arg Ile Ser Lys Ala Ser Ala Gly Thr Gly Ser Asp Ile Tyr Ile Trp 
        115                 120                 125             


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
    130                 135                 140                 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
145                 150                 155                 160 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                165                 170                 175     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            180                 185                 190         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        195                 200                 205             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    210                 215                 220                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
225                 230                 235                 240 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                245                 250                 255     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            260                 265                 270         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        275                 280                 285             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Ser Gly 
    290                 295                 300                 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
305                 310                 315                 320 


Glu Asn Pro Gly Pro Ser Met Glu Thr Pro Ala Gln Leu Leu Phe Leu 
                325                 330                 335     


Leu Leu Leu Trp Leu Pro Asp Thr Thr Gly Glu Val Gln Leu Val Glu 
            340                 345                 350         


Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        355                 360                 365             


Ala Ala Ser Gly Phe Leu Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg 
    370                 375                 380                 


Gln Ala Pro Gly Lys Glu Arg Glu Trp Val Ala Gly Ile Thr Asn Asn 
385                 390                 395                 400 


Gly Tyr Ser Thr Ala Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile 
                405                 410                 415     


Ser Arg Asp Asn Ala Lys Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu 
            420                 425                 430         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys His Ala Asp Leu Thr Lys 
        435                 440                 445             


Ala Tyr Asp Val Glu Tyr Ala Trp Gly Gln Gly Thr Leu Val Thr Val 
    450                 455                 460                 


Lys Pro Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
465                 470                 475                 480 


Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                485                 490                 495     


Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly 
            500                 505                 510         


Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn 
        515                 520                 525             


Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala 
    530                 535                 540                 


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
545                 550                 555                 560 


Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala 
                565                 570                 575     


Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser 
            580                 585                 590         


Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro 
        595                 600                 605             


Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp 
    610                 615                 620                 


Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe 
625                 630                 635                 640 


Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala 
                645                 650                 655     


Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr 
            660                 665                 670         


Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr 
        675                 680                 685             


Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala 
    690                 695                 700                 


Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu 
705                 710                 715                 720 


Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
                725                 730                 


<210>  81
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - human CD8a TM plus MH sequence

<400>  81

Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
1               5                   10                  15      


Leu Ser Leu Val Ile Thr Met His 
            20                  


<210>  82
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - human CD8a TM plus LYC sequence

<400>  82

Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
1               5                   10                  15      


Leu Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  25  


<210>  83
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - human CD8a TM plus LYS sequence

<400>  83

Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
1               5                   10                  15      


Leu Ser Leu Val Ile Thr Leu Tyr Ser 
            20                  25  


<210>  84
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  84

Gly Gly Gly Gly Ser 
1               5   


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  85

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  86

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  87
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  87

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  88
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  88

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  89

Asp Gly Gly Gly Ser 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  90

Thr Gly Glu Lys Pro 
1               5   


<210>  91
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  91

Gly Gly Arg Arg 
1               


<210>  92
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  92

Glu Gly Lys Ser Ser Gly Ser Gly Ser Glu Ser Lys Val Asp 
1               5                   10                  


<210>  93
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  93

Lys Glu Ser Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser 
1               5                   10                  15      


Leu Asp 
        


<210>  94
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  94

Gly Gly Arg Arg Gly Gly Gly Ser 
1               5               


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  95

Leu Arg Gln Arg Asp Gly Glu Arg Pro 
1               5                   


<210>  96
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  96

Leu Arg Gln Lys Asp Gly Gly Gly Ser Glu Arg Pro 
1               5                   10          


<210>  97
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  97

Leu Arg Gln Lys Asp Gly Gly Gly Ser Gly Gly Gly Ser Glu Arg Pro 
1               5                   10                  15      


<210>  98
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  polypeptide linker

<400>  98

Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr 
1               5                   10                  15      


Lys Gly 
        


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa = Gly or Ser

<400>  99

Glu Xaa Xaa Tyr Xaa Gln Xaa 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  100

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavage sequence by TEV protease

<400>  101

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  102
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  102

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  103
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  103

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  104
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  104

Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10                  


<210>  105
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  105

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  106
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  106

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  107
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  107

Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
1               5                   10              


<210>  108
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  108

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  109
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  109

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  110
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  110

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  111
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  111

Gly Ser Gly Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala 
1               5                   10                  15      


Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25  


<210>  112
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  112

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  113
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  113

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  114
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  114

Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  115
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  115

Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  116
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  116

Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
1               5                   10                  


<210>  117
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  117

Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
1               5                   10                  15      


Pro 
    


<210>  118
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  118

Gln Leu Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  119
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  119

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  120
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  120

Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala Glu Thr Tyr Cys Pro 
1               5                   10                  15      


Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys 
            20                  25                  30          


Ile Val Ala Pro Val Lys Gln Thr 
        35                  40  


<210>  121
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  121

Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  122
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  122

Leu Leu Ala Ile His Pro Thr Glu Ala Arg His Lys Gln Lys Ile Val 
1               5                   10                  15      


Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
            20                  25                  30          


Asp Val Glu Ser Asn Pro Gly Pro 
        35                  40  


<210>  123
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Self-cleaving polypeptide comprising 2A site

<400>  123

Glu Ala Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Thr Leu 
1               5                   10                  15      


Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly 
            20                  25                  30          


Pro 
    


<210>  124
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Consensus Kozak sequence

<400>  124
gccrccatgg                                                              10


<210>  125
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker polypeptide

<400>  125

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  126
<211>  408
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  126

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly 
145                 150                 155                 160 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp 
                165                 170                 175     


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val 
            180                 185                 190         


Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala 
        195                 200                 205             


Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
    210                 215                 220                 


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
225                 230                 235                 240 


Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu 
                245                 250                 255     


Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr 
            260                 265                 270         


Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys 
        275                 280                 285             


Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser 
    290                 295                 300                 


Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu 
305                 310                 315                 320 


Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln 
                325                 330                 335     


Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly 
            340                 345                 350         


His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu 
        355                 360                 365             


Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly 
    370                 375                 380                 


Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val 
385                 390                 395                 400 


Arg Cys Arg His Arg Arg Arg Gln 
                405             


<210>  127
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  127

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
145                 150                 155                 160 


Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg 
                165                 170                 175     


Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr 
        195                 200                 205             


Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys 
    210                 215                 220                 


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
225                 230                 235                 240 


Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys 
        275                 280                 285             


Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly 
    290                 295                 300                 


Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met 
305                 310                 315                 320 


Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln 
                325                 330                 335     


Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala 
            340                 345                 350         


Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu 
        355                 360                 365             


Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu 
    370                 375                 380                 


Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly 
385                 390                 395                 400 


Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg Arg Gln 
                405                 410             


<210>  128
<211>  418
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  128

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val 
145                 150                 155                 160 


Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                165                 170                 175     


Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val Met Gly Trp Tyr Arg 
            180                 185                 190         


Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala Glu Ile Ser Gly Val 
        195                 200                 205             


Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp Arg Phe Thr Val Ser 
    210                 215                 220                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
225                 230                 235                 240 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala His Ser Phe Leu Asp 
                245                 250                 255     


Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile Ser Pro Gly Asp Gly 
        275                 280                 285             


Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val Val His Tyr Thr Gly 
    290                 295                 300                 


Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser Arg Asp Arg Asn Lys 
305                 310                 315                 320 


Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val Ile Arg Gly Trp Glu 
                325                 330                 335     


Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg Ala Lys Leu Thr Ile 
            340                 345                 350         


Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His Pro Gly Ile Ile Pro 
        355                 360                 365             


Pro His Ala Thr Leu Val Phe Asp Val Glu Leu Leu Lys Leu Glu Gly 
    370                 375                 380                 


Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu 
385                 390                 395                 400 


Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg Cys Arg His Arg Arg 
                405                 410                 415     


Arg Gln 
        


<210>  129
<211>  423
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  129

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
                165                 170                 175     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile Asp Val 
            180                 185                 190         


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
        195                 200                 205             


Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu Ala Asp 
    210                 215                 220                 


Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
225                 230                 235                 240 


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ala 
                245                 250                 255     


His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr Leu Val 
            260                 265                 270         


Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu Thr Ile 
        275                 280                 285             


Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr Cys Val 
    290                 295                 300                 


Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp Ser Ser 
305                 310                 315                 320 


Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln Glu Val 
                325                 330                 335     


Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly Gln Arg 
            340                 345                 350         


Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr Gly His 
        355                 360                 365             


Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val Glu Leu 
    370                 375                 380                 


Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly Gly Val 
385                 390                 395                 400 


Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys Val Arg 
                405                 410                 415     


Cys Arg His Arg Arg Arg Gln 
            420             


<210>  130
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in Lab - tandem DARIC fusion polypeptide

<400>  130

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu 
        35                  40                  45              


Phe Ser Ile Tyr Asp Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Glu 
    50                  55                  60                  


Arg Glu Trp Val Ala Gly Ile Thr Asn Asn Gly Tyr Ser Thr Ala Tyr 
65                  70                  75                  80  


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Thr Ile Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys His Ala Asp Leu Thr Lys Ala Tyr Asp Val Glu Tyr 
        115                 120                 125             


Ala Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly Ser Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Glu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Ser Ser Gly Ile 
                165                 170                 175     


Asp Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu 
            180                 185                 190         


Val Ala Glu Ile Ser Gly Val Gly Asp Thr Asn Tyr Ala Ala Ser Leu 
        195                 200                 205             


Ala Asp Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Asn Ala His Ser Phe Leu Asp Leu Val Gly Ala Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Lys Pro Gly Gly Gly Gly Ser Gly Val Gln Val Glu 
            260                 265                 270         


Thr Ile Ser Pro Gly Asp Gly Arg Thr Phe Pro Lys Arg Gly Gln Thr 
        275                 280                 285             


Cys Val Val His Tyr Thr Gly Met Leu Glu Asp Gly Lys Lys Phe Asp 
    290                 295                 300                 


Ser Ser Arg Asp Arg Asn Lys Pro Phe Lys Phe Met Leu Gly Lys Gln 
305                 310                 315                 320 


Glu Val Ile Arg Gly Trp Glu Glu Gly Val Ala Gln Met Ser Val Gly 
                325                 330                 335     


Gln Arg Ala Lys Leu Thr Ile Ser Pro Asp Tyr Ala Tyr Gly Ala Thr 
            340                 345                 350         


Gly His Pro Gly Ile Ile Pro Pro His Ala Thr Leu Val Phe Asp Val 
        355                 360                 365             


Glu Leu Leu Lys Leu Glu Gly Gly Arg Met Ala Leu Ile Val Leu Gly 
    370                 375                 380                 


Gly Val Ala Gly Leu Leu Leu Phe Ile Gly Leu Gly Ile Phe Phe Cys 
385                 390                 395                 400 


Val Arg Cys Arg His Arg Arg Arg Gln 
                405                 


