                         SEQUENCE LISTING

<110>  Cue Biopharma, Inc.
 
<120>  T-Cell Modulatory Polypeptides with Conjugation Sites

<130>  2910-24 PCT

<150>  US 63/110,946
<151>  2020-11-06

<160>  238   

<170>  PatentIn version 3.5

<210>  1
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Ser Pro Thr Ser Pro Val Phe Pro Leu Ser Leu Cys Ser Thr Gln 
1               5                   10                  15      


Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe Pro 
            20                  25                  30          


Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val Thr 
        35                  40                  45              


Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr Thr 
    50                  55                  60                  


Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly Lys 
65                  70                  75                  80  


Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp Val 
                85                  90                  95      


Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            100                 105                 110         


Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser Leu 
        115                 120                 125             


His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn Leu 
    130                 135                 140                 


Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe Thr 
145                 150                 155                 160 


Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu Arg 
                165                 170                 175     


Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys Ala 
            180                 185                 190         


Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr Pro 
        195                 200                 205             


Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn Thr 
    210                 215                 220                 


Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu Ala 
225                 230                 235                 240 


Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser Pro 
                245                 250                 255     


Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro Arg 
            260                 265                 270         


Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly Thr 
        275                 280                 285             


Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp Trp 
    290                 295                 300                 


Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu Pro 
305                 310                 315                 320 


Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro Thr 
                325                 330                 335     


His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys Tyr 
            340                 345                 350         


<210>  2
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  2

Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg His 
1               5                   10                  15      


Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly Tyr 
            20                  25                  30          


His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser Gln 
        35                  40                  45              


Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr Met 
    50                  55                  60                  


Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly Glu 
65                  70                  75                  80  


Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu Ile 
                85                  90                  95      


Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr 
            100                 105                 110         


Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro 
        115                 120                 125             


Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu 
    130                 135                 140                 


Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys 
145                 150                 155                 160 


Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala Val 
                165                 170                 175     


Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val Val 
            180                 185                 190         


Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly Lys 
        195                 200                 205             


Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser Asn 
    210                 215                 220                 


Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu Trp 
225                 230                 235                 240 


Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu Pro 
                245                 250                 255     


Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro Val 
            260                 265                 270         


Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala Ala 
        275                 280                 285             


Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile Leu 
    290                 295                 300                 


Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe Ala 
305                 310                 315                 320 


Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser Thr Thr Phe Trp Ala Trp 
                325                 330                 335     


Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr Tyr 
            340                 345                 350         


Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala Ser 
        355                 360                 365             


Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380             


<210>  3
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Asp Pro Cys Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser 
1               5                   10                  15      


Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr 
            20                  25                  30          


Cys Leu Val Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr 
        35                  40                  45              


Trp Ser Arg Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu 
    50                  55                  60                  


Glu Lys Gln Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val 
65                  70                  75                  80  


Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr 
                85                  90                  95      


His Pro His Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105                 110         


Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
        115                 120                 125             


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
    130                 135                 140                 


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
145                 150                 155                 160 


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
                165                 170                 175     


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
            180                 185                 190         


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
        195                 200                 205             


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215                 220         


<210>  4
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  5
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  6
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 partial sequence with a L234F/L235E/P331S Triple 
       substitutions that appears as L14F/L15E/P111S substitutions in 
       the sequence shown


<220>
<221>  VARIANT
<222>  (14)..(15)
<223>  IgG L234F and L235E substitutions that appear as L14F and L15E 
       substutions in the sequence shown

<220>
<221>  VARIANT
<222>  (121)..(127)
<223>  IgG P331Ssubstitution that appear as P111S substutions in the 
       sequence shown

<400>  6

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Phe Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  7
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 partial sequence with a N297A substitution that appears as 
       an N77A substitution in the sequenc shown


<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  IgG partial sequence having an N297A substitution that appears as
       an N77A substitution in the partial sequence shown

<400>  7

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  8
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 partial sequence with LALA substitution


<220>
<221>  VARIANT
<222>  (14)..(15)
<223>  IgG partial sequence having an L234A and L235A ("LALA")  
       substitution that appears as an L14A and L15A ("LALA") 
       substitution in the partial sequence shown

<400>  8

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  9
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  9

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
1               5                   10                  15      


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr 
65                  70                  75                  80  


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr 
                85                  90                  95      


Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro 
            100                 105                 110         


Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        115                 120                 125             


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    130                 135                 140                 


Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
145                 150                 155                 160 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                165                 170                 175     


Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu 
            180                 185                 190         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala 
        195                 200                 205             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    210                 215                 220                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
225                 230                 235                 240 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                245                 250                 255     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            260                 265                 270         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        275                 280                 285             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    290                 295                 300                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
305                 310                 315                 320 


Leu Ser Pro Gly Lys 
                325 


<210>  10
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  10

His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Leu Lys Thr 
1               5                   10                  15      


Pro Leu Gly Asp Thr Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
            20                  25                  30          


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        35                  40                  45              


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    50                  55                  60                  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
65                  70                  75                  80  


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                85                  90                  95      


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            100                 105                 110         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        115                 120                 125             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    130                 135                 140                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
145                 150                 155                 160 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                165                 170                 175     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            180                 185                 190         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        195                 200                 205             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    210                 215                 220                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys 
                245     


<210>  11
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  12
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220             


<210>  13
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Phe Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro Val Ile Ala Glu Leu Pro Pro Lys 
            100                 105                 110         


Val Ser Val Phe Val Pro Pro Arg Asp Gly Phe Phe Gly Asn Pro Arg 
        115                 120                 125             


Lys Ser Lys Leu Ile Cys Gln Ala Thr Gly Phe Ser Pro Arg Gln Ile 
    130                 135                 140                 


Gln Val Ser Trp Leu Arg Glu Gly Lys Gln Val Gly Ser Gly Val Thr 
145                 150                 155                 160 


Thr Asp Gln Val Gln Ala Glu Ala Lys Glu Ser Gly Pro Thr Thr Tyr 
                165                 170                 175     


Lys Val Thr Ser Thr Leu Thr Ile Lys Glu Ser Asp Trp Leu Gly Gln 
            180                 185                 190         


Ser Met Phe Thr Cys Arg Val Asp His Arg Gly Leu Thr Phe Gln Gln 
        195                 200                 205             


Asn Ala Ser Ser Met Cys Val Pro Asp Gln Asp Thr Ala Ile Arg Val 
    210                 215                 220                 


Phe Ala Ile Pro Pro Ser Phe Ala Ser Ile Phe Leu Thr Lys Ser Thr 
225                 230                 235                 240 


Lys Leu Thr Cys Leu Val Thr Asp Leu Thr Thr Tyr Asp Ser Val Thr 
                245                 250                 255     


Ile Ser Trp Thr Arg Gln Asn Gly Glu Ala Val Lys Thr His Thr Asn 
            260                 265                 270         


Ile Ser Glu Ser His Pro Asn Ala Thr Phe Ser Ala Val Gly Glu Ala 
        275                 280                 285             


Ser Ile Cys Glu Asp Asp Trp Asn Ser Gly Glu Arg Phe Thr Cys Thr 
    290                 295                 300                 


Val Thr His Thr Asp Leu Pro Ser Pro Leu Lys Gln Thr Ile Ser Arg 
305                 310                 315                 320 


Pro Lys Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro 
                325                 330                 335     


Ala Arg Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu 
            340                 345                 350         


Val Thr Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg 
        355                 360                 365             


Gly Gln Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro 
    370                 375                 380                 


Glu Pro Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val 
385                 390                 395                 400 


Ser Glu Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala 
                405                 410                 415     


His Glu Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser 
            420                 425                 430         


Thr Gly Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr 
        435                 440                 445             


Ala Gly Thr Cys Tyr 
    450             


<210>  14
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala Gln Glu Asp Glu Arg Ile Val Leu Val Asp 
            20                  25                  30          


Asn Lys Cys Lys Cys Ala Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser 
        35                  40                  45              


Glu Asp Pro Asn Glu Asp Ile Val Glu Arg Asn Ile Arg Ile Ile Val 
    50                  55                  60                  


Pro Leu Asn Asn Arg Glu Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg 
65                  70                  75                  80  


Thr Arg Phe Val Tyr His Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro 
                85                  90                  95      


Thr Glu Val Glu Leu Asp Asn Gln Ile Val Thr Ala Thr Gln Ser Asn 
            100                 105                 110         


Ile Cys Asp Glu Asp Ser Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg 
        115                 120                 125             


Asn Lys Cys Tyr Thr Ala Val Val Pro Leu Val Tyr Gly Gly Glu Thr 
    130                 135                 140                 


Lys Met Val Glu Thr Ala Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
145                 150                 155                 


<210>  15
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  15

Phe Thr Val Arg Glu Thr Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
1               5                   10                  15      


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
            20                  25                  30          


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
        35                  40                  45              


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
    50                  55                  60                  


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
65                  70                  75                  80  


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
                85                  90                  95      


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
            100                 105                 110         


<210>  16
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  16

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  17
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  18
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Lys Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Met Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Ala Asn Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Val His Ala 
                165                 170                 175     


Ala Glu Gln Arg Arg Val Tyr Leu Glu Gly Arg Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  19
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Gln Glu Thr Arg Asn Val Lys Ala Gln Ser Gln 
                85                  90                  95      


Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Ile Gln Ile Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Phe Leu Arg Gly Tyr Arg Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Ala 
                165                 170                 175     


Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Arg Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Leu Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Thr Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  20
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Val Met Ala Pro Arg Thr Leu Val Leu Leu Leu Ser Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Ser Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Glu Glu Thr Gly Lys Val Lys Ala His Ser Gln 
                85                  90                  95      


Thr Asp Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Met Met Phe Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu Ala Ala His Val 
                165                 170                 175     


Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys Val Asp Gly Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Leu Gly Ala 
305                 310                 315                 320 


Val Ile Thr Gly Ala Val Val Ala Ala Val Met Trp Arg Arg Asn Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  21
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Val Met Ala Pro Arg Thr Leu Leu Leu Leu Leu Leu Gly Ala 
1               5                   10                  15      


Leu Ala Leu Thr Gln Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Thr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Arg Asn Val Lys Ala His Ser Gln 
                85                  90                  95      


Ile Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Ile Gln Met Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Ser Asp Gly Arg Phe Leu Arg Gly Tyr Gln Gln Asp Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Met Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Val 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Pro 
        195                 200                 205             


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ser Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Val Gly Ile Ile Ala Gly Leu Val Leu Phe Gly Ala 
305                 310                 315                 320 


Val Phe Ala Gly Ala Val Val Ala Ala Val Arg Trp Arg Arg Lys Ser 
                325                 330                 335     


Ser Asp Arg Lys Gly Gly Ser Tyr Ser Gln Ala Ala Ser Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Met Ser Leu Thr Ala Cys Lys Val 
        355                 360                 365 


<210>  22
<211>  362
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Leu Val Met Ala Pro Arg Thr Val Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Gly Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Tyr Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Glu Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Asn Thr Gln Ile Tyr Lys Ala Gln Ala Gln 
                85                  90                  95      


Thr Asp Arg Glu Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Ala Gly Ser His Thr Leu Gln Ser Met Tyr Gly Cys Asp Val Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly His Asp Gln Tyr Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Trp Glu Ala Ala Arg Glu 
                165                 170                 175     


Ala Glu Gln Arg Arg Ala Tyr Leu Glu Gly Glu Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Asp Lys Leu Glu Arg Ala Asp Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Ile Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Arg Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
        275                 280                 285             


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser 
    290                 295                 300                 


Thr Val Pro Ile Val Gly Ile Val Ala Gly Leu Ala Val Leu Ala Val 
305                 310                 315                 320 


Val Val Ile Gly Ala Val Val Ala Ala Val Met Cys Arg Arg Lys Ser 
                325                 330                 335     


Ser Gly Gly Lys Gly Gly Ser Tyr Ser Gln Ala Ala Cys Ser Asp Ser 
            340                 345                 350         


Ala Gln Gly Ser Asp Val Ser Leu Thr Ala 
        355                 360         


<210>  23
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Val Met Ala Pro Arg Ala Leu Leu Leu Leu Leu Ser Gly Gly 
1               5                   10                  15      


Leu Ala Leu Thr Glu Thr Trp Ala Cys Ser His Ser Met Arg Tyr Phe 
            20                  25                  30          


Asp Thr Ala Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ser 
        35                  40                  45              


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
    50                  55                  60                  


Ala Ser Pro Arg Gly Glu Pro Arg Ala Pro Trp Val Glu Gln Glu Gly 
65                  70                  75                  80  


Pro Glu Tyr Trp Asp Arg Glu Thr Gln Asn Tyr Lys Arg Gln Ala Gln 
                85                  90                  95      


Ala Asp Arg Val Ser Leu Arg Asn Leu Arg Gly Tyr Tyr Asn Gln Ser 
            100                 105                 110         


Glu Asp Gly Ser His Thr Leu Gln Arg Met Tyr Gly Cys Asp Leu Gly 
        115                 120                 125             


Pro Asp Gly Arg Leu Leu Arg Gly Tyr Asp Gln Ser Ala Tyr Asp Gly 
    130                 135                 140                 


Lys Asp Tyr Ile Ala Leu Asn Glu Asp Leu Arg Ser Trp Thr Ala Ala 
145                 150                 155                 160 


Asp Thr Ala Ala Gln Ile Thr Gln Arg Lys Leu Glu Ala Ala Arg Ala 
                165                 170                 175     


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
            180                 185                 190         


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Ala Glu Pro 
        195                 200                 205             


Pro Lys Thr His Val Thr His His Pro Leu Ser Asp His Glu Ala Thr 
    210                 215                 220                 


Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
225                 230                 235                 240 


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
                245                 250                 255     


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
            260                 265                 270         


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Met Gln His Glu 
        275                 280                 285             


Gly Leu Gln Glu Pro Leu Thr Leu Ser Trp Glu Pro Ser Ser Gln Pro 
    290                 295                 300                 


Thr Ile Pro Ile Met Gly Ile Val Ala Gly Leu Ala Val Leu Val Val 
305                 310                 315                 320 


Leu Ala Val Leu Gly Ala Val Val Thr Ala Met Met Cys Arg Arg Lys 
                325                 330                 335     


Ser Ser Gly Gly Lys Gly Gly Ser Cys Ser Gln Ala Ala Cys Ser Asn 
            340                 345                 350         


Ser Ala Gln Gly Ser Asp Glu Ser Leu Ile Thr Cys Lys 
        355                 360                 365 


<210>  24
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Lys Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Met Lys Ala His Ser Gln Thr Asp Arg Ala Asn Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Val His Ala Ala Glu Gln Arg Arg Val Tyr Leu 
145                 150                 155                 160 


Glu Gly Arg Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Leu 
        275     


<210>  25
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  26
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  26

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu 
            260                 265                 270         


Ser Trp Glu 
        275 


<210>  27
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  28
<211>  274
<212>  PRT
<213>  Mus musculus

<400>  28

Gly Pro His Ser Leu Arg Tyr Phe Val Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Leu Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Asp Asn Pro Arg Phe Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Pro Glu Tyr Trp Glu Glu Gln Thr 
    50                  55                  60                  


Gln Arg Ala Lys Ser Asp Glu Gln Trp Phe Arg Val Ser Leu Arg Thr 
65                  70                  75                  80  


Ala Gln Arg Tyr Tyr Asn Gln Ser Lys Gly Gly Ser His Thr Phe Gln 
                85                  90                  95      


Arg Met Phe Gly Cys Asp Val Gly Ser Asp Trp Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Phe Ala Tyr Asp Gly Arg Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Lys Thr Trp Thr Ala Ala Asp Thr Ala Ala Leu Ile Thr Arg 
    130                 135                 140                 


Arg Lys Trp Glu Gln Ala Gly Asp Ala Glu Tyr Tyr Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Leu Gly Asn 
                165                 170                 175     


Glu Thr Leu Leu Arg Thr Asp Ser Pro Lys Ala His Val Thr Tyr His 
            180                 185                 190         


Pro Arg Ser Gln Val Asp Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Asp Ile Thr Leu Thr Trp Gln Leu Asn Gly Glu Asp Leu 
    210                 215                 220                 


Thr Gln Asp Met Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Leu Gly Lys Glu Gln Asn 
                245                 250                 255     


Tyr Thr Cys His Val His His Lys Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp 
        


<210>  29
<211>  275
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (84)..(84)
<223>  Y84A substitution

<220>
<221>  VARIANT
<222>  (236)..(236)
<223>  A236C  substitution

<400>  29

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  30
<211>  275
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (84)..(84)
<223>  Y84C substitution

<220>
<221>  VARIANT
<222>  (139)..(139)
<223>  Y139C substitution

<220>
<221>  VARIANT
<222>  (139)..(139)
<223>  A236C substitution

<400>  30

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  31
<211>  276
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (89)..(89)
<223>  Y84A substitution

<220>
<221>  VARIANT
<222>  (236)..(236)
<223>  A236C substitution

<400>  31

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Ala Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  32
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  32

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala His Ala Ala Glu Gln Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Arg Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Leu 
        275     


<210>  33
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  33

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr 
    50                  55                  60                  


Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  34
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Ser His Ser Met Arg Tyr Phe Thr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala His Ser Gln Ile Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Met Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ser Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  35
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  35

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gln Glu Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Ile Met Tyr Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Arg Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala His Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Asp Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Leu 
        275     


<210>  36
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  36

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr 
    50                  55                  60                  


Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  37
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  37

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr 
    50                  55                  60                  


Gly Lys Val Lys Ala Gln Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  38
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  38

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Gln Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Thr Ala His Glu Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ser Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  39
<211>  276
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X1 is F, Y, S, or T

<220>
<221>  VARIANT
<222>  (44)..(44)
<223>  X2 is K or R

<220>
<221>  VARIANT
<222>  (62)..(62)
<223>  X3 is Q, G, E, or R

<220>
<221>  VARIANT
<222>  (63)..(63)
<223>  X4 is N or E

<220>
<221>  VARIANT
<222>  (65)..(65)
<223>  X5 is R or G

<220>
<221>  VARIANT
<222>  (66)..(66)
<223>  X6 is N or K

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  X7 is M or V

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  X8 is H or Q

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  X9 is T or I

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  X10 is D or H

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  X11 is A, V, or E

<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  X12 is N or D

<220>
<221>  VARIANT
<222>  (79)..(79)
<223>  X13 is G or R

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  X14 is T or I

<220>
<221>  VARIANT
<222>  (81)..(81)
<223>  X15 is L or A

<220>
<221>  VARIANT
<222>  (82)..(82)
<223>  X16 is R or L

<220>
<221>  VARIANT
<222>  (83)..(83)
<223>  X17 is G or R

<220>
<221>  VARIANT
<222>  (90)..(90)
<223>  X18 is A or D

<220>
<221>  VARIANT
<222>  (95)..(95)
<223>  X19 is I, L, or V

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  X20 is I, R or M

<220>
<221>  VARIANT
<222>  (99)..(99)
<223>  X21 is F or Y

<220>
<221>  VARIANT
<222>  (105)..(105)
<223>  X22 is S or P

<220>
<221>  VARIANT
<222>  (107)..(107)
<223>  X23 is W or G

<220>
<221>  VARIANT
<222>  (114)..(114)
<223>  X24 is R, H, or Q

<220>
<221>  VARIANT
<222>  (116)..(116)
<223>  X25 is D or Y

<220>
<221>  VARIANT
<222>  (127)..(127)
<223>  X26 is N or K

<220>
<221>  VARIANT
<222>  (142)..(142)
<223>  X27 is T or I

<220>
<221>  VARIANT
<222>  (144)..(144)
<223>  X28 is K or Q

<220>
<221>  VARIANT
<222>  (145)..(145)
<223>  X29 is R or H

<220>
<221>  VARIANT
<222>  (149)..(149)
<223>  X30 is A or T

<220>
<221>  VARIANT
<222>  (150)..(150)
<223>  X31 is A or V

<220>
<221>  VARIANT
<222>  (151)..(151)
<223>  X32 is A or V

<220>
<221>  VARIANT
<222>  (156)..(156)
<223>  X33 is R, L, Q, or W

<220>
<221>  VARIANT
<222>  (158)..(158)
<223>  X34 is V or A

<220>
<221>  VARIANT
<222>  (161)..(161)
<223>  X35 is D or E

<220>
<221>  VARIANT
<222>  (163)..(163)
<223>  X36 is R or T

<220>
<221>  VARIANT
<222>  (166)..(166)
<223>  X37 is D or E

<220>
<221>  VARIANT
<222>  (167)..(167)
<223>  X38 is W or G

<220>
<221>  VARIANT
<222>  (184)..(184)
<223>  X39 is P or A

<220>
<221>  VARIANT
<222>  (193)..(193)
<223>  X40 is P or A

<220>
<221>  VARIANT
<222>  (194)..(194)
<223>  X41 is V or I

<220>
<221>  VARIANT
<222>  (207)..(207)
<223>  X42 is S or G

<220>
<221>  VARIANT
<222>  (246)..(246)
<223>  X43 is A or S

<220>
<221>  VARIANT
<222>  (253)..(253)
<223>  X44 is Q or E

<220>
<221>  VARIANT
<222>  (276)..(276)
<223>  X45 is P or L

<400>  39

Gly Ser His Ser Met Arg Tyr Phe Xaa Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Xaa Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Xaa Xaa Thr 
    50                  55                  60                  


Xaa Xaa Xaa Lys Ala Xaa Ser Gln Xaa Xaa Arg Xaa Xaa Leu Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Tyr Tyr Asn Gln Ser Glu Xaa Gly Ser His Thr Xaa Gln 
                85                  90                  95      


Xaa Met Xaa Gly Cys Asp Val Gly Xaa Asp Xaa Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Xaa Gln Xaa Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Xaa Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Xaa Thr Xaa 
    130                 135                 140                 


Xaa Lys Trp Glu Xaa Xaa Xaa Glu Ala Glu Gln Xaa Arg Xaa Tyr Leu 
145                 150                 155                 160 


Xaa Gly Xaa Cys Val Xaa Xaa Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Xaa Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Xaa Xaa Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Xaa Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Xaa Val Val Val Pro Ser Gly Xaa Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Xaa 
        275     


<210>  40
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Tyr Lys Ala Gln Ala Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  41
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  41

Gly Ser His Ser Met Arg Tyr Phe Asp Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Phe Lys Thr Asn Thr Gln Thr Asp Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Ser Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Thr Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  42
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Met Ala Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  43
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  43

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Glu Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Cys Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Thr 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Thr Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  44
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  44

Gly Ser His Ser Met Arg Tyr Phe His Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asn Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Gln 
    130                 135                 140                 


Arg Lys Leu Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Asp Lys Leu Glu Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  45
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  45

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Met Ala Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  46
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  47
<211>  276
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X1 is H, Y, or D

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  X2 is A or S

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  X3 is M or V

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X4 is A, S, or T

<220>
<221>  VARIANT
<222>  (32)..(32)
<223>  X5 is Q or L

<220>
<221>  VARIANT
<222>  (41)..(41)
<223>  X6 is A or T

<220>
<221>  VARIANT
<222>  (45)..(45)
<223>  X7 is E, M K, or T

<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  X8 is A or T

<220>
<221>  VARIANT
<222>  (63)..(63)
<223>  X9 is E or N

<220>
<221>  VARIANT
<222>  (66)..(66)
<223>  X10 is I or K

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  X11 is Y, F, S, or C

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  X12 is N or Q

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  X13 is A or T

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  X14 is D or Y

<220>
<221>  VARIANT
<222>  (76)..(76)
<223>  X15 is E or V

<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  X16 is S or N

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  X17 is T, N, or I

<220>
<221>  VARIANT
<222>  (81)..(81)
<223>  X18 is A or L

<220>
<221>  VARIANT
<222>  (82)..(82)
<223>  X19 is L, or R

<220>
<221>  VARIANT
<222>  (83)..(83)
<223>  X20 is R or G

<220>
<221>  VARIANT
<222>  (94)..(94)
<223>  X21 is T or I

<220>
<221>  VARIANT
<222>  (95)..(95)
<223>  X22 is L or I

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  X23 is R or S

<220>
<221>  VARIANT
<222>  (131)..(131)
<223>  X24 is R or S

<220>
<221>  VARIANT
<222>  (143)..(143)
<223>  X25 is S or T

<220>
<221>  VARIANT
<222>  (147)..(147)
<223>  X26 is L or W

<220>
<221>  VARIANT
<222>  (152)..(152)
<223>  X27 is E or V

<220>
<221>  VARIANT
<222>  (156)..(156)
<223>  X28 is R, D, L or W

<220>
<221>  VARIANT
<222>  (158)..(158)
<223>  X29 is A or T

<220>
<221>  VARIANT
<222>  (163)..(163)
<223>  X30 is L, E or T

<220>
<221>  VARIANT
<222>  (177)..(177)
<223>  X31 is E or D

<220>
<221>  VARIANT
<222>  (178)..(178)
<223>  X32 is K or T

<220>
<221>  VARIANT
<222>  (180)..(180)
<223>  X33 is E or Q

<220>
<221>  VARIANT
<222>  (194)..(194)
<223>  X34 is I or V

<400>  47

Gly Ser His Ser Met Arg Tyr Phe Xaa Thr Xaa Xaa Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Xaa Val Gly Tyr Val Asp Asp Thr Xaa 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Xaa Ser Pro Arg Xaa Xaa Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Xaa Thr 
    50                  55                  60                  


Gln Xaa Xaa Lys Thr Xaa Xaa Thr Gln Xaa Tyr Xaa Xaa Asn Leu Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Xaa Xaa Gln 
                85                  90                  95      


Xaa Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Xaa Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Xaa Gln 
    130                 135                 140                 


Arg Lys Xaa Glu Ala Ala Arg Xaa Ala Glu Gln Xaa Arg Xaa Tyr Leu 
145                 150                 155                 160 


Glu Gly Xaa Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Xaa Xaa Leu Xaa Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Xaa Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  48
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  48

Cys Ser His Ser Met Lys Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Cys Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Trp Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Met Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  49
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro His Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Arg Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Trp Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  50
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  50

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro His Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Lys Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Trp Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  51
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  51

Gly Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Trp Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Glu Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Asn Leu Arg Lys 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Phe Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Arg Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Trp Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Lys Pro 
        275     


<210>  52
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  52

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Asn Leu Arg Lys 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  53
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  53

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Asn Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu 
            260                 265                 270         


Ser Trp Glu Pro 
        275     


<210>  54
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  54

Cys Ser His Ser Met Arg Tyr Phe Asp Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Ala Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Asp Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Ser Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Leu Glu Ala Ala Arg Ala Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Leu Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Met Gln His Glu Gly Leu Gln Glu Pro Leu Thr Leu 
            260                 265                 270         


Ser Trp Glu Pro 
        275     


<210>  55
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  55

Cys Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Gln Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Lys Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asn Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Thr Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Lys Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Gly Pro 
        275     


<210>  56
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  56

Cys Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro His Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Asn Tyr Lys Arg Gln Ala Gln Thr Asp Arg Val Asn Leu Arg Lys 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Leu Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Glu Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Glu His Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  57
<211>  276
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  X1 is C or G

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  X2 is R or K

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  X3 is F, Y, S, or D

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  X4 is R or W

<220>
<221>  VARIANT
<222>  (21)..(21)
<223>  X5 is H or R

<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  X6 is A or S

<220>
<221>  VARIANT
<222>  (35)..(35)
<223>  X7 is Q or R

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  X8 is A or E

<220>
<221>  VARIANT
<222>  (66)..(66)
<223>  X9 is N or K

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  X10 is T or A

<220>
<221>  VARIANT
<222>  (77)..(77)
<223>  X11 is S or N

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  X11 is S or N

<220>
<221>  VARIANT
<222>  (90)..(90)
<223>  X13 is A or D

<220>
<221>  VARIANT
<222>  (91)..(91)
<223>  X14 is G or R

<220>
<221>  VARIANT
<222>  (94)..(94)
<223>  X15 is T or I

<220>
<221>  VARIANT
<222>  (95)..(95)
<223>  X16 is L or I

<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  X17 is W or R

<220>
<221>  VARIANT
<222>  (99)..(99)
<223>  X18 is C, Y, F, or S

<220>
<221>  VARIANT
<222>  (103)..(103)
<223>  X19 is L, or V

<220>
<221>  VARIANT
<222>  (113)..(113)
<223>  X20 is Y or H

<220>
<221>  VARIANT
<222>  (114)..(114)
<223>  X21 is D or N

<220>
<221>  VARIANT
<222>  (116)..(116)
<223>  X22 is Y, F, S, or L

<220>
<221>  VARIANT
<222>  (147)..(147)
<223>  X23 is L or W

<220>
<221>  VARIANT
<222>  (152)..(152)
<223>  X24 is E, A, or T

<220>
<221>  VARIANT
<222>  (156)..(156)
<223>  X25 is R, L, or W

<220>
<221>  VARIANT
<222>  (163)..(163)
<223>  X26 is L or T

<220>
<221>  VARIANT
<222>  (173)..(173)
<223>  X27 is E or K

<220>
<221>  VARIANT
<222>  (177)..(177)
<223>  X28 is E or K

<220>
<221>  VARIANT
<222>  (184)..(184)
<223>  X29 is H or P

<220>
<221>  VARIANT
<222>  (194)..(194)
<223>  X30 is R or V

<220>
<221>  VARIANT
<222>  (219)..(219)
<223>  X31 is W or R

<220>
<221>  VARIANT
<222>  (248)..(248)
<223>  X32 is V or M

<220>
<221>  VARIANT
<222>  (253)..(253)
<223>  X33 is E or Q

<220>
<221>  VARIANT
<222>  (261)..(261)
<223>  X34 is M or V

<220>
<221>  VARIANT
<222>  (267)..(267)
<223>  X35 is P or Q

<220>
<221>  VARIANT
<222>  (273)..(273)
<223>  X36 is R or S

<220>
<221>  VARIANT
<222>  (275)..(275)
<223>  X37 is P or G

<400>  57

Xaa Ser His Ser Met Xaa Tyr Phe Xaa Thr Ala Val Ser Xaa Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Xaa Phe Ile Xaa Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Xaa Phe Asp Ser Asp Ala Ala Ser Pro Arg Gly Glu Pro Arg 
        35                  40                  45              


Xaa Pro Trp Val Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Xaa Tyr Lys Arg Gln Ala Gln Xaa Asp Arg Val Xaa Leu Arg Xaa 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Xaa Xaa Ser His Xaa Xaa Gln 
                85                  90                  95      


Xaa Met Xaa Gly Cys Asp Xaa Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Xaa Xaa Gln Xaa Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Xaa Glu Ala Ala Arg Xaa Ala Glu Gln Xaa Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Xaa Cys Val Glu Trp Leu Arg Arg Tyr Leu Xaa Asn Gly Lys 
                165                 170                 175     


Xaa Thr Leu Gln Arg Ala Glu Xaa Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Xaa Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Xaa Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Xaa Val Pro Ser Gly Xaa Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Xaa Gln His Glu Gly Leu Xaa Glu Pro Leu Thr Leu 
            260                 265                 270         


Xaa Trp Xaa Pro 
        275     


<210>  58
<211>  284
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (89)..(89)
<223>  X1= K or E

<220>
<221>  VARIANT
<222>  (107)..(107)
<223>  X2= R or G

<220>
<221>  VARIANT
<222>  (157)..(157)
<223>  X3= R or G

<220>
<221>  VARIANT
<222>  (158)..(158)
<223>  X4= A or V

<220>
<221>  VARIANT
<222>  (255)..(255)
<223>  X5= Q or P

<220>
<221>  VARIANT
<222>  (267)..(267)
<223>  X6= P or S

<400>  58

Gly Ser His Ser Leu Lys Tyr Phe His Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ser Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Asn Asp Ala Ala Ser Pro Arg Met Val Pro Arg 
        35                  40                  45              


Ala Pro Trp Met Glu Gln Glu Gly Ser Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Arg Ser Ala Arg Asp Thr Ala Gln Ile Phe Arg Val Asn Leu Arg Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Xaa Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met His Gly Cys Glu Leu Gly Pro Asp Xaa Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr Glu Gln Phe Ala Tyr Asp Gly Lys Asp Tyr Leu Thr Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Val Asp Thr Ala Ala Gln Ile Ser Glu 
    130                 135                 140                 


Gln Lys Ser Asn Asp Ala Ser Glu Ala Glu His Gln Xaa Xaa Tyr Leu 
145                 150                 155                 160 


Glu Asp Thr Cys Val Glu Trp Leu His Lys Tyr Leu Glu Lys Gly Lys 
                165                 170                 175     


Glu Thr Leu Leu His Leu Glu Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Gln Asp Gly Glu Gly His 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Xaa Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Xaa Glu Pro Val Thr Leu 
            260                 265                 270         


Arg Trp Lys Pro Ala Ser Gln Pro Thr Ile Pro Ile 
        275                 280                 


<210>  59
<211>  284
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  X1= Y or F

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  X2= P or Q

<220>
<221>  VARIANT
<222>  (251)..(251)
<223>  X3= S or P

<220>
<221>  VARIANT
<222>  (278)..(278)
<223>  X4= P or L

<400>  59

Gly Ser His Ser Leu Arg Xaa Phe Ser Thr Ala Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Tyr Ile Ala Val Glu Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Leu Arg Phe Asp Ser Asp Ala Ala Ile Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Glu Xaa Trp Val Glu Gln Glu Gly Pro Gln Tyr Trp Glu Trp Thr Thr 
    50                  55                  60                  


Gly Tyr Ala Lys Ala Asn Ala Gln Thr Asp Arg Val Ala Leu Arg Asn 
65                  70                  75                  80  


Leu Leu Arg Arg Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln 
                85                  90                  95      


Gly Met Asn Gly Cys Asp Met Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr His Gln His Ala Tyr Asp Gly Lys Asp Tyr Ile Ser Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Val Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Phe Tyr Glu Ala Glu Glu Tyr Ala Glu Glu Phe Arg Thr Tyr Leu 
145                 150                 155                 160 


Glu Gly Glu Cys Leu Glu Leu Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Ala His Val Ala His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Glu Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Xaa Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Gln Pro Leu Ile Leu 
            260                 265                 270         


Arg Trp Glu Gln Ser Xaa Gln Pro Thr Ile Pro Ile 
        275                 280                 


<210>  60
<211>  284
<212>  PRT
<213>  Homo sapiens


<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  X1= S or F

<220>
<221>  VARIANT
<222>  (27)..(27)
<223>  X2= Y or H

<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  X3= T, S, or M

<220>
<221>  VARIANT
<222>  (34)..(34)
<223>  X4= L or V

<220>
<221>  VARIANT
<222>  (54)..(54)
<223>  X5= Q or R

<220>
<221>  VARIANT
<222>  (81)..(81)
<223>  X6= P or L

<220>
<221>  VARIANT
<222>  (100)..(100)
<223>  X7= G or D

<220>
<221>  VARIANT
<222>  (104)..(104)
<223>  X8= G or V

<220>
<221>  VARIANT
<222>  (105)..(105)
<223>  X9= S or C

<220>
<221>  VARIANT
<222>  (110)..(110)
<223>  X10= L or I

<220>
<221>  VARIANT
<222>  (159)..(159)
<223>  X11= Y or H

<220>
<221>  VARIANT
<222>  (169)..(169)
<223>  X12= H or R

<220>
<221>  VARIANT
<222>  (171)..(171)
<223>  X13= Y or H

<220>
<221>  VARIANT
<222>  (178)..(178)
<223>  X14= M or T

<220>
<221>  VARIANT
<222>  (185)..(185)
<223>  X15= P or A

<220>
<221>  VARIANT
<222>  (219)..(219)
<223>  X16= R, W, or Q

<220>
<221>  VARIANT
<222>  (258)..(258)
<223>  X17= T or M

<220>
<221>  VARIANT
<222>  (275)..(275)
<223>  X18= K or E

<400>  60

Gly Ser His Ser Met Arg Tyr Phe Ser Ala Ala Val Xaa Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Met Gly Xaa Val Asp Asp Xaa Gln 
            20                  25                  30          


Phe Xaa Arg Phe Asp Ser Asp Ser Ala Cys Pro Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Val Glu Xaa Glu Gly Pro Glu Tyr Trp Glu Glu Glu Thr 
    50                  55                  60                  


Arg Asn Thr Lys Ala His Ala Gln Thr Asp Arg Met Asn Leu Gln Thr 
65                  70                  75                  80  


Xaa Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Ser Ser His Thr Leu Gln 
                85                  90                  95      


Trp Met Ile Xaa Cys Asp Leu Xaa Xaa Asp Gly Arg Leu Xaa Arg Gly 
            100                 105                 110         


Tyr Glu Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Leu Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Ser Lys 
    130                 135                 140                 


Arg Lys Cys Glu Ala Ala Asn Val Ala Glu Gln Arg Arg Ala Xaa Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Xaa Arg Xaa Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Xaa Leu Gln Arg Ala Asp Pro Xaa Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Phe Asp Tyr Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Ile Leu Thr Trp Gln Xaa Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Val Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Xaa Cys His Val Gln His Glu Gly Leu Pro Glu Pro Leu Met Leu 
            260                 265                 270         


Arg Trp Xaa Gln Ser Ser Leu Pro Thr Ile Pro Ile 
        275                 280                 


<210>  61
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  61

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  62
<211>  119
<212>  PRT
<213>  Pan troglodytes

<400>  62

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  63
<211>  119
<212>  PRT
<213>  Macaca mulatta

<400>  63

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Met Gly Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Asn Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gly Pro Arg Thr 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met 
        115                 


<210>  64
<211>  118
<212>  PRT
<213>  Bos taurus

<400>  64

Met Ala Arg Phe Val Ala Leu Val Leu Leu Gly Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Asp Ala Ile Gln Arg Pro Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asp Gly Lys Pro Asn Tyr Leu Asn Cys Tyr Val Tyr 
        35                  40                  45              


Gly Phe His Pro Pro Gln Ile Glu Ile Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Lys Ile Lys Ser Glu Gln Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser 
65                  70                  75                  80  


Phe Tyr Leu Leu Ser His Ala Glu Phe Thr Pro Asn Ser Lys Asp Gln 
                85                  90                  95      


Tyr Ser Cys Arg Val Lys His Val Thr Leu Glu Gln Pro Arg Ile Val 
            100                 105                 110         


Lys Trp Asp Arg Asp Leu 
        115             


<210>  65
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  65

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ile Gln Lys Thr Pro Gln Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Pro Glu Asn Gly Lys Pro Asn Ile Leu Asn Cys Tyr Val Thr 
        35                  40                  45              


Gln Phe His Pro Pro His Ile Glu Ile Gln Met Leu Lys Asn Gly Lys 
    50                  55                  60                  


Lys Ile Pro Lys Val Glu Met Ser Asp Met Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Ile Leu Ala His Thr Glu Phe Thr Pro Thr Glu Thr Asp 
                85                  90                  95      


Thr Tyr Ala Cys Arg Val Lys His Ala Ser Met Ala Glu Pro Lys Thr 
            100                 105                 110         


<210>  66
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase Motif


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Position 1 of the motif X1Z1X2Z2X3Z3, the X1 residue, may be  
       present or absent and, when present, can be any aa, though 
       usually an aliphatic aa, a sulfur-containing aa, or a polar 
       uncharged aa usually L, M, V, S or T, more usually L, M, S or V

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Position 2 of the motif X1Z1X2Z2X3Z3, the Z1 residue, is cysteine
       or serine

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Position 3 of the motif X1Z1X2Z2X3Z3, the X2 residue, can be any 
       aa, though usually an aliphatic aa, a polar, uncharged aa, or a 
       sulfur containing aa (e.g., other than an aromatic aa or a 
       charged aa), usually S, T, A, V, G or C, more usually S, T, A, V 
       

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Position 4 of the motif X1Z1X2Z2X3Z3, the Z2 residue, Z2 is 
       either a proline or alanine residue

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Position 5 of the motif X1Z1X2Z2X3Z3, the X3 residue, can be any 
       aa, though usually an aliphatic aa, a polar, uncharged aa, or a 
       sulfur containing aa (e.g., other than an aromatic aa or a 
       charged aa), usually S, T, A, V, G or C, more usually S, T, A, V 
       

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Position 6 of the motif X1Z1X2Z2X3Z3, the Z3 residue, is a basic 
       aa (arginine, lysine, or histidine, usually lysine), or an 
       aliphatic aa (alanine, glycine, leucine, valine, isoleucine, or 
       proline, usually A, G, L, V, or I)

<400>  66

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  67
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase Motif


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Position 1 of the motif X1CX2PX3Z3, the X1, may be  present or 
       absent and, when present, can be any aa, though usually an 
       aliphatic aa, a sulfur-containing aa, or a polar uncharged aa 
       usually L, M, V, S or T, more usually L, M, S or V

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Position 3 of the motif X1CX2PX3Z3, the X2 residue can be any aa,
       though usually an aliphatic aa, a polar, uncharged aa, or a 
       sulfur containing aa (e.g., other than an aromatic aa or a 
       charged aa), usually S, T, A, V, G or C, more usually S, T, A, V 
       

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Position 5 of the motif X1CX2PX3Z3, the X3 residue can be any aa,
       though usually an aliphatic aa, a polar, uncharged aa, or a 
       sulfur containing aa (e.g., other than an aromatic aa or a 
       charged aa), usually S, T, A, V, G or C, more usually S, T, A, V 
       

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Position 6 of the motif X1CX2PX3Z3, the Z3 residue, is a basic aa
       (arginine, lysine, or histidine, usually lysine), or an aliphatic
       aa (alanine, glycine, leucine, valine, isoleucine, or proline, 
       usually A, G, L, V, or I)

<400>  67

Xaa Cys Xaa Pro Xaa Xaa 
1               5       


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sulfatase Motif


<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Position 2 of the motif X CX1PX2Z3, the X1, may be  present or 
       absent and, when present, can be any aa, though usually an 
       aliphatic aa, a sulfur-containing aa, or a polar uncharged aa 
       usually L, M, V, S or T, more usually L, M, S or V

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Position 4 of the motif CX1PX2Z3, the X2 residue can be any aa, 
       though usually an aliphatic aa, a polar, uncharged aa, or a 
       sulfur containing aa (e.g., other than an aromatic aa or a 
       charged aa), usually S, T, A, V, G or C, more usually S, T, A, V 
       

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Position 5 of the motif CX1PX2Z3, the Z3 residue, is a basic aa 
       (arginine, lysine, or histidine, usually lysine), or an aliphatic
       aa (alanine, glycine, leucine, valine, isoleucine, or proline, 
       usually A, G, L, V, or I)

<400>  68

Cys Xaa Pro Xaa Xaa 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase Motif


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Position 3 can be any amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Position 5 is glycine or alanine

<400>  69

Leu Pro Xaa Thr Xaa 
1               5   


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase Motif GGGG

<400>  70

Gly Gly Gly Gly 
1               


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase Motif GGGGG

<400>  71

Gly Gly Gly Gly Gly 
1               5   


<210>  72
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase Motif AAAA

<400>  72

Ala Ala Ala Ala 
1               


<210>  73
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase Motif AAAAA

<400>  73

Ala Ala Ala Ala Ala 
1               5   


<210>  74
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase Motif LPETGG

<400>  74

Leu Pro Glu Thr Gly Gly 
1               5       


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sortase Motif LPETAA

<400>  75

Leu Pro Glu Thr Ala Ala 
1               5       


<210>  76
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q-tag LLQGG

<400>  76

Leu Leu Gln Gly Gly 
1               5   


<210>  77
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q-tag LLQG

<400>  77

Leu Leu Gln Gly 
1               


<210>  78
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q-tag LSLSQG

<400>  78

Leu Ser Leu Ser Gln Gly 
1               5       


<210>  79
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q-tag LLQLQG

<400>  79

Leu Leu Gln Leu Gln Gly 
1               5       


<210>  80
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  80

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Gln Ile Phe Lys Thr Asn Thr Gln Thr Tyr Arg Glu Ser Leu Arg Asn 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu 
        275 


<210>  81
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  81

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Thr 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Asp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Ser Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  82
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  82

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Thr Val Gly Tyr Val Asp Asp Thr Leu 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Thr Ser Pro Arg Lys Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Glu Thr 
    50                  55                  60                  


Gln Ile Ser Lys Thr Asn Thr Gln Thr Tyr Arg Glu Asn Leu Arg Thr 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


Tyr Asp Gln Asp Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Ser Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Ile Ser Asp His Glu Val Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  83
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  83

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ala Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Pro Arg Thr Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Asn Met Lys Ala Ser Ala Gln Thr Tyr Arg Glu Asn Leu Arg Ile 
65                  70                  75                  80  


Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Ile Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Leu Gly Pro Asp Gly Arg Leu Leu Arg Gly 
            100                 105                 110         


His Asp Gln Ser Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Asn Glu 
        115                 120                 125             


Asp Leu Ser Ser Trp Thr Ala Ala Asp Thr Ala Ala Gln Ile Thr Gln 
    130                 135                 140                 


Arg Lys Trp Glu Ala Ala Arg Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Leu Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Ala Asp Pro Pro Lys Thr His Val Thr His His 
            180                 185                 190         


Pro Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Arg Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  84
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   HLA Class I variant with Y84C, A139C, and A236C substitutions


<220>
<221>  VARIANT
<222>  (79)..(83)
<223>  Any of residues 79-83 may be present or absent, when present they
       are each selected independently from proteinogenic amino acids or
       any proteinogenic amino acid amino acid other than glycine, in an
       embodiment it is the sequence GTLRG

<220>
<221>  VARIANT
<222>  (84)..(84)
<223>  Residue 84 can form a disulfide bond

<220>
<221>  VARIANT
<222>  (85)..(89)
<223>  Any of residues 85-89 may be present or absent, when present they
       are each selected independently from proteinogenic amino acids or
       any proteinogenic amino acid amino acid other than glycine, in an
       embodiment it is the sequence YNQSE

<220>
<221>  VARIANT
<222>  (134)..(138)
<223>  Any of residues 134-138 may be present or absent, when present 
       they are each selected independently from proteinogenic amino 
       acids or any proteinogenic amino acid amino acid other than 
       glycine, in an embodiment it is the sequence TAADM

<220>
<221>  VARIANT
<222>  (139)..(139)
<223>  Residue 139 can form a disulfide bond

<220>
<221>  VARIANT
<222>  (140)..(144)
<223>  Any of residues 140-144 may be present or absent, when present 
       they are each selected independently from proteinogenic amino 
       acids or any proteinogenic amino acid amino acid other than 
       glycine, in an embodiment it is the sequence AQITK

<220>
<221>  VARIANT
<222>  (231)..(235)
<223>  Any of residues 231-235 may be present or absent, when present 
       they are each selected independently from proteinogenic amino 
       acids or any proteinogenic amino acid amino acid other than 
       glycine, in an embodiment it is the sequence VETRP

<220>
<221>  VARIANT
<222>  (236)..(236)
<223>  When aa236 is a cysteine it can form a disulfide bond with a 
       Beta-2 Microglobulin-containing polypeptide, in alternative 
       embodiments aa  236 can be an Ala.

<220>
<221>  VARIANT
<222>  (237)..(241)
<223>  Any of residues 237-241 may be present or absent, when present 
       they are each selected independently from proteinogenic amino 
       acids or any proteinogenic amino acid amino acid other than 
       glycine, in an embodiment it is the sequence GDGTF

<400>  84

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Xaa Xaa Xaa Xaa Xaa Cys Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro 
        275     


<210>  85
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GTLRG peptide

<400>  85

Gly Thr Leu Arg Gly 
1               5   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  YNQSE peptide

<400>  86

Tyr Asn Gln Ser Glu 
1               5   


<210>  87
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TAADM peptide

<400>  87

Thr Ala Ala Asp Met 
1               5   


<210>  88
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AQTTK peptide

<400>  88

Ala Gln Thr Thr Lys 
1               5   


<210>  89
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine Zipper Polypeptide

<400>  89

Arg Met Lys Gln Ile Glu Asp Lys Ile Glu Glu Ile Leu Ser Lys Ile 
1               5                   10                  15      


Tyr His Ile Glu Asn Glu Ile Ala Arg Ile Lys Lys Leu Ile Gly Glu 
            20                  25                  30          


Arg 
    


<210>  90
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine zipper polypeptide

<400>  90

Leu Ser Ser Ile Glu Lys Lys Gln Glu Glu Gln Thr Ser Trp Leu Ile 
1               5                   10                  15      


Trp Ile Ser Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln Ser 
            20                  25                  30          


<210>  91
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine Zipper Polypeptide

<400>  91

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Ile Ser Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  92
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine Zipper Polypeptide

<400>  92

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Ile Arg Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  93
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine Zipper Polypeptide

<400>  93

Leu Ser Ser Ile Glu Lys Lys Leu Glu Glu Ile Thr Ser Gln Leu Gln 
1               5                   10                  15      


Gln Ile Arg Asn Glu Leu Thr Leu Ile Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  94
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine Zipper Polypeptide

<400>  94

Leu Ser Ser Leu Glu Lys Lys Leu Glu Glu Leu Thr Ser Gln Leu Ile 
1               5                   10                  15      


Gln Leu Arg Asn Glu Leu Thr Leu Leu Arg Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  95
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine Zipper Polypeptide

<400>  95

Ile Ser Ser Leu Glu Lys Lys Ile Glu Glu Leu Thr Ser Gln Ile Gln 
1               5                   10                  15      


Gln Leu Arg Asn Glu Ile Thr Leu Leu Arg Asn Glu Ile Ala Gln 
            20                  25                  30      


<210>  96
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucine Zipper Polypeptide

<400>  96

Leu Glu Ile Glu Ala Ala Phe Leu Glu Arg Glu Asn Thr Ala Leu Glu 
1               5                   10                  15      


Thr Arg Val Ala Glu Leu Arg Gln Arg Val Gln Arg Leu Arg Asn Arg 
            20                  25                  30          


Val Ser Gln Tyr Arg Thr Arg Tyr Gly Pro Leu Gly Gly Gly Lys 
        35                  40                  45          


<210>  97
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil polypeptide

<400>  97

Leu Lys Ser Val Glu Asn Arg Leu Ala Val Val Glu Asn Gln Leu Lys 
1               5                   10                  15      


Thr Val Ile Glu Glu Leu Lys Thr Val Lys Asp Leu Leu Ser Asn 
            20                  25                  30      


<210>  98
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   coiled-coil polypeptide

<400>  98

Leu Ala Arg Ile Glu Glu Lys Leu Lys Thr Ile Lys Ala Gln Leu Ser 
1               5                   10                  15      


Glu Ile Ala Ser Thr Leu Asn Met Ile Arg Glu Gln Leu Ala Gln 
            20                  25                  30      


<210>  99
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>   coiled-coil polypeptide

<400>  99

Val Ser Arg Leu Glu Glu Lys Val Lys Thr Leu Lys Ser Gln Val Thr 
1               5                   10                  15      


Glu Leu Ala Ser Thr Val Ser Leu Leu Arg Glu Gln Val Ala Gln 
            20                  25                  30      


<210>  100
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil polypeptide

<400>  100

Ile Gln Ser Glu Lys Lys Ile Glu Asp Ile Ser Ser Leu Ile Gly Gln 
1               5                   10                  15      


Ile Gln Ser Glu Ile Thr Leu Ile Arg Asn Glu Ile Ala Gln 
            20                  25                  30  


<210>  101
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil polypeptide

<400>  101

Leu Met Ser Leu Glu Lys Lys Leu Glu Glu Leu Thr Gln Thr Leu Met 
1               5                   10                  15      


Gln Leu Gln Asn Glu Leu Ser Met Leu Lys Asn Glu Leu Ala Gln 
            20                  25                  30      


<210>  102
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil polypeptide

<400>  102

Val Asp Leu Glu Gly Ser Thr Ser Asn Gly Arg Gln Cys Ala Gly Ile 
1               5                   10                  15      


Arg Leu 
        


<210>  103
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil polypeptide

<400>  103

Glu Asp Asp Val Thr Thr Thr Glu Glu Leu Ala Pro Ala Leu Val Pro 
1               5                   10                  15      


Pro Pro Lys Gly Thr Cys Ala Gly Trp Met Ala 
            20                  25          


<210>  104
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  coiled-coil polypeptide

<400>  104

Gly His Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro 
1               5                   10                  15      


Leu Pro Lys Gly Ala Cys Thr Gly Gln Met Ala 
            20                  25          


<210>  105
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  collagen oligomerization peptide

<400>  105

Val Thr Ala Phe Ser Asn Met Asp Asp Met Leu Gln Lys Ala His Leu 
1               5                   10                  15      


Val Ile Glu Gly Thr Phe Ile Tyr Leu Arg Asp Ser Thr Glu Phe Phe 
            20                  25                  30          


Ile Arg Val Arg Asp Gly Trp Lys Lys Leu Gln Leu Gly Glu Leu Ile 
        35                  40                  45              


Pro Ile Pro Ala Asp Ser Pro Pro Pro Pro Ala Leu Ser Ser Asn Pro 
    50                  55                  60                  


<210>  106
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  106

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  107
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  107

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210>  108
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  108

Val Asn Gly Thr Ser Gln Phe Thr Cys Phe Tyr Asn Ser Arg Ala Asn 
1               5                   10                  15      


Ile Ser Cys Val Trp Ser Gln Asp Gly Ala Leu Gln Asp Thr Ser Cys 
            20                  25                  30          


Gln Val His Ala Trp Pro Asp Arg Arg Arg Trp Asn Gln Thr Cys Glu 
        35                  40                  45              


Leu Leu Pro Val Ser Gln Ala Ser Trp Ala Cys Asn Leu Ile Leu Gly 
    50                  55                  60                  


Ala Pro Asp Ser Gln Lys Leu Thr Thr Val Asp Ile Val Thr Leu Arg 
65                  70                  75                  80  


Val Leu Cys Arg Glu Gly Val Arg Trp Arg Val Met Ala Ile Gln Asp 
                85                  90                  95      


Phe Lys Pro Phe Glu Asn Leu Arg Leu Met Ala Pro Ile Ser Leu Gln 
            100                 105                 110         


Val Val His Val Glu Thr His Arg Cys Asn Ile Ser Trp Glu Ile Ser 
        115                 120                 125             


Gln Ala Ser His Tyr Phe Glu Arg His Leu Glu Phe Glu Ala Arg Thr 
    130                 135                 140                 


Leu Ser Pro Gly His Thr Trp Glu Glu Ala Pro Leu Leu Thr Leu Lys 
145                 150                 155                 160 


Gln Lys Gln Glu Trp Ile Cys Leu Glu Thr Leu Thr Pro Asp Thr Gln 
                165                 170                 175     


Tyr Glu Phe Gln Val Arg Val Lys Pro Leu Gln Gly Glu Phe Thr Thr 
            180                 185                 190         


Trp Ser Pro Trp Ser Gln Pro Leu Ala Phe Arg Thr Lys Pro Ala Ala 
        195                 200                 205             


Leu Gly Lys Asp Thr Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu 
    210                 215                 220                 


Ser Gly Ala Phe Gly Phe Ile Ile Leu Val Tyr Leu Leu Ile Asn Cys 
225                 230                 235                 240 


Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn Thr Pro 
                245                 250                 255     


Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly Gly Asp 
            260                 265                 270         


Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe Ser Pro 
        275                 280                 285             


Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu Arg Asp 
    290                 295                 300                 


Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu Pro Ala 
305                 310                 315                 320 


Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly 
                325                 330                 335     


Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln 
            340                 345                 350         


Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly 
        355                 360                 365             


Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu 
    370                 375                 380                 


Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu 
385                 390                 395                 400 


Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr 
                405                 410                 415     


Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu 
            420                 425                 430         


Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro 
        435                 440                 445             


Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu 
    450                 455                 460                 


Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu 
465                 470                 475                 480 


Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg 
                485                 490                 495     


Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu 
            500                 505                 510         


Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        515                 520                 


<210>  109
<211>  347
<212>  PRT
<213>  Homo sapiens

<400>  109

Leu Asn Thr Thr Ile Leu Thr Pro Asn Gly Asn Glu Asp Thr Thr Ala 
1               5                   10                  15      


Asp Phe Phe Leu Thr Thr Met Pro Thr Asp Ser Leu Ser Val Ser Thr 
            20                  25                  30          


Leu Pro Leu Pro Glu Val Gln Cys Phe Val Phe Asn Val Glu Tyr Met 
        35                  40                  45              


Asn Cys Thr Trp Asn Ser Ser Ser Glu Pro Gln Pro Thr Asn Leu Thr 
    50                  55                  60                  


Leu His Tyr Trp Tyr Lys Asn Ser Asp Asn Asp Lys Val Gln Lys Cys 
65                  70                  75                  80  


Ser His Tyr Leu Phe Ser Glu Glu Ile Thr Ser Gly Cys Gln Leu Gln 
                85                  90                  95      


Lys Lys Glu Ile His Leu Tyr Gln Thr Phe Val Val Gln Leu Gln Asp 
            100                 105                 110         


Pro Arg Glu Pro Arg Arg Gln Ala Thr Gln Met Leu Lys Leu Gln Asn 
        115                 120                 125             


Leu Val Ile Pro Trp Ala Pro Glu Asn Leu Thr Leu His Lys Leu Ser 
    130                 135                 140                 


Glu Ser Gln Leu Glu Leu Asn Trp Asn Asn Arg Phe Leu Asn His Cys 
145                 150                 155                 160 


Leu Glu His Leu Val Gln Tyr Arg Thr Asp Trp Asp His Ser Trp Thr 
                165                 170                 175     


Glu Gln Ser Val Asp Tyr Arg His Lys Phe Ser Leu Pro Ser Val Asp 
            180                 185                 190         


Gly Gln Lys Arg Tyr Thr Phe Arg Val Arg Ser Arg Phe Asn Pro Leu 
        195                 200                 205             


Cys Gly Ser Ala Gln His Trp Ser Glu Trp Ser His Pro Ile His Trp 
    210                 215                 220                 


Gly Ser Asn Thr Ser Lys Glu Asn Pro Phe Leu Phe Ala Leu Glu Ala 
225                 230                 235                 240 


Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
                245                 250                 255     


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
            260                 265                 270         


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
        275                 280                 285             


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
    290                 295                 300                 


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
305                 310                 315                 320 


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
                325                 330                 335     


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            340                 345         


<210>  110
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 variant polypeptide with substitutions at H16 and F42


<220>
<221>  VARIANT
<222>  (16)..(16)
<223>  X1 is any aa other than His.  In some embodiments it may be Ala 
       or Thr.

<220>
<221>  VARIANT
<222>  (42)..(42)
<223>  X2 is any aa other than Phe.  In some embodiments it may be Ala 
       or Thr

<400>  110

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Xaa 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Xaa Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  111
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  111

Gly Ser Gly Gly Ser 
1               5   


<210>  112
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  112

Gly Gly Gly Ser 
1               


<210>  113
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  113

Gly Gly Ser Gly 
1               


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  114

Gly Gly Ser Gly Gly 
1               5   


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  115

Gly Ser Gly Ser Gly 
1               5   


<210>  116
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  116

Gly Ser Gly Gly Gly 
1               5   


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  117

Gly Gly Gly Ser Gly 
1               5   


<210>  118
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  118

Gly Ser Ser Ser Gly 
1               5   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  119

Gly Ser Ser Ser Ser 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  120

Gly Gly Gly Gly Ser 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Xaa can be Gly, Ser, Leu, Cys, Met, or Ala

<400>  121

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  122

Ala Ala Ala Gly Gly 
1               5   


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  123

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  124
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  124

Gly Cys Gly Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  125
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  125

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  126

Gly Cys Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  127
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag

<400>  127

Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope tag

<400>  128

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  129
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity domain

<400>  129

His His His His His 
1               5   


<210>  130
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity domain

<400>  130

His His His His His His 
1               5       


<210>  131
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity domain

<400>  131

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  132
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity domain

<400>  132

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  133
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity domain

<400>  133

Arg Tyr Ile Arg Ser 
1               5   


<210>  134
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity domain

<400>  134

Phe His His Thr 
1               


<210>  135
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Affinity domain

<400>  135

Trp Glu Ala Ala Ala Arg Glu Ala Cys Cys Arg Glu Cys Cys Ala Arg 
1               5                   10                  15      


Ala 
    


<210>  136
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  136

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Trp Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  137
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  137

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  138
<211>  188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS variant


<220>
<221>  X1
<222>  (5)..(5)
<223>  Lys, Phe, or Leu

<220>
<221>  X1
<222>  (5)..(5)
<223>  Lys, Phe, or Leu

<220>
<221>  X2
<222>  (7)..(7)
<223>  Val or Leu

<220>
<221>  X3
<222>  (8)..(8)
<223>  Val or Thr

<220>
<221>  X4
<222>  (9)..(9)
<223>  Val or Thr

<220>
<221>  X5
<222>  (12)..(12)
<223>  Gly, Asp, Cys, Val, or Ser

<220>
<221>  X6
<222>  (13)..(13)
<223>  Gly, Cys, or Asp

<400>  138

Met Thr Glu Tyr Xaa Leu Xaa Xaa Xaa Gly Ala Xaa Xaa Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Trp Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  139

Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  140

Val Val Gly Ala Cys Gly Val Gly Lys 
1               5                   


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  141

Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  142

Val Val Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10  


<210>  143
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  143

Val Val Val Gly Ala Val Gly Val Gly Lys 
1               5                   10  


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  144

Val Val Val Gly Ala Cys Gly Val Gly Lys 
1               5                   10  


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  145

Val Thr Gly Ala Asp Gly Val Gly Lys 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  146

Val Thr Gly Ala Val Gly Val Gly Lys 
1               5                   


<210>  147
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  147

Val Thr Gly Ala Cys Gly Val Gly Lys 
1               5                   


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  148

Val Thr Val Gly Ala Asp Gly Val Gly Lys 
1               5                   10  


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  149

Val Thr Val Gly Ala Val Gly Val Gly Lys 
1               5                   10  


<210>  150
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  150

Val Thr Val Gly Ala Cys Gly Val Gly Lys 
1               5                   10  


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  151

Val Val Val Gly Ala Gly Asp Val Gly Lys 
1               5                   10  


<210>  152
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  152

Val Val Gly Ala Gly Asp Val Gly Lys 
1               5                   


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  153

Val Val Val Gly Ala Arg Gly Val Gly Lys 
1               5                   10  


<210>  154
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  154

Val Val Gly Ala Arg Gly Val Gly Lys 
1               5                   


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  155

Leu Val Val Val Gly Ala Asp Gly Val 
1               5                   


<210>  156
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  156

Leu Val Val Val Gly Ala Val Gly Val 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  157

Leu Val Val Val Gly Ala Cys Gly Val 
1               5                   


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  158

Lys Leu Val Val Val Gly Ala Asp Gly Val 
1               5                   10  


<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  159

Lys Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10  


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  160

Lys Leu Val Val Val Gly Ala Cys Gly Val 
1               5                   10  


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  161

Leu Leu Val Val Gly Ala Asp Gly Val 
1               5                   


<210>  162
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  162

Leu Leu Val Val Gly Ala Val Gly Val 
1               5                   


<210>  163
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  163

Leu Leu Val Val Gly Ala Cys Gly Val 
1               5                   


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  164

Phe Leu Val Val Val Gly Ala Asp Gly Val 
1               5                   10  


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  165

Phe Leu Val Val Val Gly Ala Val Gly Val 
1               5                   10  


<210>  166
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  166

Lys Leu Val Val Val Gly Ala Gly Asp Val 
1               5                   10  


<210>  167
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  167

Lys Leu Val Val Val Gly Ala Arg Gly Val 
1               5                   10  


<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  168

Gly Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   10  


<210>  169
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  169

Ala Gly Asp Val Gly Lys Ser Ala Leu 
1               5                   


<210>  170
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  170

Asp Val Gly Lys Ser Ala Leu Thr Ile 
1               5                   


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  171

Gly Ala Val Gly Val Gly Lys Ser Ala Leu 
1               5                   10  


<210>  172
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  172

Ala Val Gly Val Gly Lys Ser Ala Leu 
1               5                   


<210>  173
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  173

Tyr Lys Leu Val Val Val Gly Ala Val 
1               5                   


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  174

Ala Arg Gly Val Gly Lys Ser Ala Leu 
1               5                   


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  175

Gly Ala Arg Gly Val Gly Lys Ser Ala Leu 
1               5                   10  


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  176

Glu Tyr Lys Leu Val Val Val Gly Ala Arg 
1               5                   10  


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  177

Arg Gly Val Gly Lys Ser Ala Leu Thr Ile 
1               5                   10  


<210>  178
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  178

Leu Val Val Val Gly Ala Arg Gly Val 
1               5                   


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  179

Gly Ala Asp Gly Val Gly Lys Ser Ala Leu 
1               5                   10  


<210>  180
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  180

Ala Cys Gly Val Gly Lys Ser Ala Leu 
1               5                   


<210>  181
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  181

Gly Ala Cys Gly Val Gly Lys Ser Ala Leu 
1               5                   10  


<210>  182
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  182

Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   


<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  183

Val Gly Ala Val Gly Val Gly Lys Ser Ala 
1               5                   10  


<210>  184
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  184

Ala Val Gly Val Gly Lys Ser Ala Leu Thr 
1               5                   10  


<210>  185
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  185

Gly Ala Val Gly Val Gly Lys Ser Ala 
1               5                   


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  186

Leu Val Val Val Gly Ala Val Gly Val Gly 
1               5                   10  


<210>  187
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  187

Lys Leu Val Val Val Gly Ala Val Gly 
1               5                   


<210>  188
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  188

Phe Leu Val Val Val Gly Ala Cys Gly Val 
1               5                   10  


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  189

Lys Leu Val Val Gly Ala Asp Gly Val 
1               5                   


<210>  190
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  190

Lys Leu Val Val Gly Ala Val Gly Val 
1               5                   


<210>  191
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  191

Lys Leu Val Val Val Ala Val Gly Val 
1               5                   


<210>  192
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  KRAS peptide

<400>  192

Lys Leu Val Val Val Ala Asp Gly Val 
1               5                   


<210>  193
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 1694 polypeptide

<400>  193

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg 
305                 310                 315                 320 


Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp 
                325                 330                 335     


Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu 
            340                 345                 350         


Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly 
        355                 360                 365             


Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu 
    370                 375                 380                 


Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr 
385                 390                 395                 400 


Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu 
                405                 410                 415     


Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu 
            420                 425                 430         


Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr 
        435                 440                 445             


Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala 
    450                 455                 460                 


Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn 
465                 470                 475                 480 


Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr 
                485                 490                 495     


His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu 
            500                 505                 510         


Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu 
        515                 520                 525             


Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp 
    530                 535                 540                 


Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu 
545                 550                 555                 560 


Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu 
                565                 570                 575     


Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys 
            580                 585                 590         


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
        595                 600                 605             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    610                 615                 620                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
625                 630                 635                 640 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                645                 650                 655     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            660                 665                 670         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        675                 680                 685             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    690                 695                 700                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
705                 710                 715                 720 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                725                 730                 735     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            740                 745                 750         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        755                 760                 765             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    770                 775                 780                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
785                 790                 795                 800 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                805                 810             


<210>  194
<211>  813
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  split chain construct 4008 polypeptide

<400>  194

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg 
305                 310                 315                 320 


Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp 
                325                 330                 335     


Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu 
            340                 345                 350         


Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly 
        355                 360                 365             


Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu 
    370                 375                 380                 


Gly Thr Leu Arg Gly Tyr Cys Asn Gln Ser Glu Ala Gly Ser His Thr 
385                 390                 395                 400 


Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu 
                405                 410                 415     


Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu 
            420                 425                 430         


Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Cys Met Ala Ala Gln Thr 
        435                 440                 445             


Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala 
    450                 455                 460                 


Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn 
465                 470                 475                 480 


Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr 
                485                 490                 495     


His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu 
            500                 505                 510         


Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu 
        515                 520                 525             


Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp 
    530                 535                 540                 


Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu 
545                 550                 555                 560 


Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu 
                565                 570                 575     


Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys 
            580                 585                 590         


Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
        595                 600                 605             


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
    610                 615                 620                 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
625                 630                 635                 640 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
                645                 650                 655     


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
            660                 665                 670         


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
        675                 680                 685             


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
    690                 695                 700                 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
705                 710                 715                 720 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
                725                 730                 735     


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
            740                 745                 750         


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
        755                 760                 765             


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
    770                 775                 780                 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
785                 790                 795                 800 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                805                 810             


<210>  195
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 2686 polypeptide

<400>  195

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  196
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CMV epitope peptide

<400>  196

Asn Leu Val Pro Met Val Ala Thr Val 
1               5                   


<210>  197
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3861 polypeptide

<400>  197

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  198
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MART-1 peptide

<400>  198

Glu Leu Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  199
<211>  773
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3984 polypeptide

<400>  199

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile 
145                 150                 155                 160 


Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu 
                165                 170                 175     


Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu 
            180                 185                 190         


Leu Lys Asn Gly Cys Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser 
        195                 200                 205             


Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr 
    210                 215                 220                 


Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu 
225                 230                 235                 240 


Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met 
            260                 265                 270         


Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg 
        275                 280                 285             


Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp 
    290                 295                 300                 


Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu 
305                 310                 315                 320 


Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala 
                325                 330                 335     


His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr 
            340                 345                 350         


Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys 
        355                 360                 365             


Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala 
    370                 375                 380                 


Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp 
385                 390                 395                 400 


Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys His Lys Trp Glu Ala 
                405                 410                 415     


Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val 
            420                 425                 430         


Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg 
        435                 440                 445             


Thr Asp Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp His 
    450                 455                 460                 


Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile 
465                 470                 475                 480 


Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu 
                485                 490                 495     


Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala 
            500                 505                 510         


Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val 
        515                 520                 525             


Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala 
    530                 535                 540                 


Ala Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
545                 550                 555                 560 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                565                 570                 575     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            580                 585                 590         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        595                 600                 605             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    610                 615                 620                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
625                 630                 635                 640 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                645                 650                 655     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            660                 665                 670         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        675                 680                 685             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    690                 695                 700                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
705                 710                 715                 720 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                725                 730                 735     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            740                 745                 750         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        755                 760                 765             


Ser Leu Ser Pro Gly 
    770             


<210>  200
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3985 polypeptide

<400>  200

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Leu Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  201
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3986 polypeptide

<400>  201

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  202
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3987 polypeptide

<400>  202

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Leu Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  203
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3988 polypeptide

<400>  203

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Met Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  204
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3989 polypeptide

<400>  204

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Met Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  205
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3990 polypeptide

<400>  205

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Met Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  206
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3991 polypeptide

<400>  206

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Met Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  207
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3992 polypeptide

<400>  207

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Met Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  208
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3993 polypeptide

<400>  208

Gly Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala 
            20                  25                  30          


Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His 
        35                  40                  45              


Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile Glu 
    50                  55                  60                  


Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr 
65                  70                  75                  80  


Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala 
                85                  90                  95      


Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp 
            100                 105                 110         


Asp Arg Asp Met 
        115     


<210>  209
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3994 polypeptide

<400>  209

Gly Met Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile 
1               5                   10                  15      


Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn 
            20                  25                  30          


Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser 
        35                  40                  45              


Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile Glu Lys Val 
    50                  55                  60                  


Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu 
65                  70                  75                  80  


Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg 
                85                  90                  95      


Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg 
            100                 105                 110         


Asp Met 
        


<210>  210
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3995 polypeptide

<400>  210

Gly Met Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg 
1               5                   10                  15      


Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys 
            20                  25                  30          


Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile 
        35                  40                  45              


Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile Glu Lys Val Glu His 
    50                  55                  60                  


Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr 
65                  70                  75                  80  


Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn 
                85                  90                  95      


His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
            100                 105                 110         


<210>  211
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3996

<400>  211

Gly Met Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro 
1               5                   10                  15      


Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn 
            20                  25                  30          


Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val 
        35                  40                  45              


Asp Leu Leu Lys Asn Gly Cys Arg Ile Glu Lys Val Glu His Ser Asp 
    50                  55                  60                  


Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu 
65                  70                  75                  80  


Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val 
                85                  90                  95      


Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
            100                 105                 110 


<210>  212
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3997 polypeptide

<400>  212

Gly Met Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile 
1               5                   10                  15      


Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu 
            20                  25                  30          


Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu 
        35                  40                  45              


Leu Lys Asn Gly Cys Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser 
    50                  55                  60                  


Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr 
65                  70                  75                  80  


Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu 
                85                  90                  95      


Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
            100                 105             


<210>  213
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3998 polypeptide

<400>  213

Gly Met Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val 
1               5                   10                  15      


Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys 
            20                  25                  30          


Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys 
        35                  40                  45              


Asn Gly Cys Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser 
    50                  55                  60                  


Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr 
65                  70                  75                  80  


Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln 
                85                  90                  95      


Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
            100                 105     


<210>  214
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 3999 polypeptide

<400>  214

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Leu Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  215
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4000 construct

<400>  215

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Met Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  216
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4001 polypeptide

<400>  216

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Met Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  217
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4002 polypeptide

<400>  217

Asn Leu Val Pro Met Val Ala Thr Val Gly Gly Gly Ala Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln 
            20                  25                  30          


Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn 
        35                  40                  45              


Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu 
    50                  55                  60                  


Lys Asn Gly Cys Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe 
65                  70                  75                  80  


Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro 
                85                  90                  95      


Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser 
            100                 105                 110         


Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
        115                 120             


<210>  218
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4003 polypeptide

<400>  218

Asn Leu Val Pro Met Val Ala Thr Val Gly Gly Gly Ala Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser His Val Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys 
            20                  25                  30          


Arg Ala Leu Glu Asn Leu Leu Gly Gly Gly Gly Ser Ile Gln Arg Thr 
        35                  40                  45              


Pro Lys Ile Gln Val Tyr Ser Cys His Pro Ala Glu Asn Gly Lys Ser 
    50                  55                  60                  


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
65                  70                  75                  80  


Val Asp Leu Leu Lys Asn Gly Cys Arg Ile Glu Lys Val Glu His Ser 
                85                  90                  95      


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
            100                 105                 110         


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
        115                 120                 125             


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met 
    130                 135                 140             


<210>  219
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4004 polypeptide

<400>  219

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val 
305                 310                 315                 320 


Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys 
                325                 330                 335     


Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys 
            340                 345                 350         


Asn Gly Cys Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser 
        355                 360                 365             


Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr 
    370                 375                 380                 


Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln 
385                 390                 395                 400 


Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr 
            420                 425                 430         


Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile 
        435                 440                 445             


Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp 
    450                 455                 460                 


Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu 
465                 470                 475                 480 


Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser 
                485                 490                 495     


Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln 
            500                 505                 510         


Ser Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val 
        515                 520                 525             


Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp 
    530                 535                 540                 


Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala 
545                 550                 555                 560 


Ala Asp Met Cys Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His 
                565                 570                 575     


Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp 
            580                 585                 590         


Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp 
        595                 600                 605             


Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala 
    610                 615                 620                 


Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu 
625                 630                 635                 640 


Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val 
                645                 650                 655     


Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val 
            660                 665                 670         


Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His 
        675                 680                 685             


Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly 
    690                 695                 700                 


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
705                 710                 715                 720 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                725                 730                 735     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            740                 745                 750         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        755                 760                 765             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    770                 775                 780                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
785                 790                 795                 800 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                805                 810                 815     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            820                 825                 830         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        835                 840                 845             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    850                 855                 860                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
865                 870                 875                 880 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                885                 890                 895     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            900                 905                 910         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        915                 920                 925             


Ser Pro Gly 
    930     


<210>  220
<211>  936
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4005 polypeptide

<400>  220

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Gln Arg Thr 
305                 310                 315                 320 


Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu Asn Gly Lys Ser 
                325                 330                 335     


Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro Ser Asp Ile Glu 
            340                 345                 350         


Val Asp Leu Leu Lys Asn Gly Cys Arg Ile Glu Lys Val Glu His Ser 
        355                 360                 365             


Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu Leu Tyr Tyr Thr 
    370                 375                 380                 


Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys Arg Val Asn His 
385                 390                 395                 400 


Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp Arg Asp Met Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
            420                 425                 430         


His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly 
        435                 440                 445             


Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val 
    450                 455                 460                 


Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro 
465                 470                 475                 480 


Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys 
                485                 490                 495     


Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg 
            500                 505                 510         


Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg Met 
        515                 520                 525             


Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His 
    530                 535                 540                 


Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu 
545                 550                 555                 560 


Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys His Lys 
                565                 570                 575     


Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly 
            580                 585                 590         


Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr 
        595                 600                 605             


Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His Ala Val 
    610                 615                 620                 


Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro 
625                 630                 635                 640 


Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln 
                645                 650                 655     


Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
            660                 665                 670         


Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr 
        675                 680                 685             


Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp 
    690                 695                 700                 


Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
705                 710                 715                 720 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                725                 730                 735     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            740                 745                 750         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        755                 760                 765             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    770                 775                 780                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
785                 790                 795                 800 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                805                 810                 815     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            820                 825                 830         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        835                 840                 845             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    850                 855                 860                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
865                 870                 875                 880 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                885                 890                 895     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            900                 905                 910         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        915                 920                 925             


Lys Ser Leu Ser Leu Ser Pro Gly 
    930                 935     


<210>  221
<211>  921
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4006 polypeptide

<400>  221

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg 
            420                 425                 430         


Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe 
        435                 440                 445             


Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala 
    450                 455                 460                 


Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg 
465                 470                 475                 480 


Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu 
                485                 490                 495     


Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg 
            500                 505                 510         


Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr 
        515                 520                 525             


His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp 
    530                 535                 540                 


Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys His 
545                 550                 555                 560 


Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu 
                565                 570                 575     


Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu 
            580                 585                 590         


Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His Ala 
        595                 600                 605             


Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr 
    610                 615                 620                 


Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr 
625                 630                 635                 640 


Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe 
                645                 650                 655     


Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr 
            660                 665                 670         


Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg 
        675                 680                 685             


Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys 
    690                 695                 700                 


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
705                 710                 715                 720 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                725                 730                 735     


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            740                 745                 750         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        755                 760                 765             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    770                 775                 780                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
785                 790                 795                 800 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                805                 810                 815     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
            820                 825                 830         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        835                 840                 845             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    850                 855                 860                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
865                 870                 875                 880 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                885                 890                 895     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            900                 905                 910         


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920     


<210>  222
<211>  916
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4007 polypeptide

<400>  222

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg 
                405                 410                 415     


Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe 
            420                 425                 430         


Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser 
        435                 440                 445             


Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln 
    450                 455                 460                 


Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His 
465                 470                 475                 480 


Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn 
                485                 490                 495     


Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp 
            500                 505                 510         


Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr 
        515                 520                 525             


Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr 
    530                 535                 540                 


Ala Ala Asp Met Cys Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala 
545                 550                 555                 560 


His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu 
                565                 570                 575     


Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr 
            580                 585                 590         


Asp Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu 
        595                 600                 605             


Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr 
    610                 615                 620                 


Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu 
625                 630                 635                 640 


Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala 
                645                 650                 655     


Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln 
            660                 665                 670         


His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala 
        675                 680                 685             


Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
    690                 695                 700                 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
705                 710                 715                 720 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                725                 730                 735     


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
            740                 745                 750         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
        755                 760                 765             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    770                 775                 780                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
785                 790                 795                 800 


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                805                 810                 815     


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
            820                 825                 830         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        835                 840                 845             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    850                 855                 860                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
865                 870                 875                 880 


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
                885                 890                 895     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            900                 905                 910         


Leu Ser Pro Gly 
        915     


<210>  223
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2 variant

<400>  223

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  224
<211>  946
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4125 polypeptide

<400>  224

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe 
        435                 440                 445             


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
    450                 455                 460                 


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
465                 470                 475                 480 


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
                485                 490                 495     


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
            500                 505                 510         


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser 
        515                 520                 525             


Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 
    530                 535                 540                 


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
545                 550                 555                 560 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
                565                 570                 575     


Asp Met Cys Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
            580                 585                 590         


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
        595                 600                 605             


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
    610                 615                 620                 


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
625                 630                 635                 640 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
                645                 650                 655     


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
            660                 665                 670         


Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
        675                 680                 685             


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
    690                 695                 700                 


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly 
705                 710                 715                 720 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                725                 730                 735     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            740                 745                 750         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        755                 760                 765             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    770                 775                 780                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
785                 790                 795                 800 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                805                 810                 815     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            820                 825                 830         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        835                 840                 845             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    850                 855                 860                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
865                 870                 875                 880 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                885                 890                 895     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            900                 905                 910         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        915                 920                 925             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    930                 935                 940                 


Pro Gly 
945     


<210>  225
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4126 polypeptide

<400>  225

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser 
        435                 440                 445             


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp 
    450                 455                 460                 


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met 
465                 470                 475                 480 


Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp 
                485                 490                 495     


Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp 
            500                 505                 510         


Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His 
        515                 520                 525             


Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe 
    530                 535                 540                 


Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala 
545                 550                 555                 560 


Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln 
                565                 570                 575     


Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg 
            580                 585                 590         


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu 
        595                 600                 605             


Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met 
    610                 615                 620                 


Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala 
625                 630                 635                 640 


Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly 
                645                 650                 655     


Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly 
            660                 665                 670         


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln 
        675                 680                 685             


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro 
    690                 695                 700                 


Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr 
705                 710                 715                 720 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
                725                 730                 735     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            740                 745                 750         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        755                 760                 765             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    770                 775                 780                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
785                 790                 795                 800 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                805                 810                 815     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            820                 825                 830         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        835                 840                 845             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    850                 855                 860                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
865                 870                 875                 880 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                885                 890                 895     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            900                 905                 910         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        915                 920                 925             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    930                 935                 940     


<210>  226
<211>  936
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4127 polypeptide

<400>  226

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
            420                 425                 430         


His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly 
        435                 440                 445             


Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val 
    450                 455                 460                 


Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro 
465                 470                 475                 480 


Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys 
                485                 490                 495     


Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg 
            500                 505                 510         


Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg Met 
        515                 520                 525             


Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His 
    530                 535                 540                 


Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu 
545                 550                 555                 560 


Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys His Lys 
                565                 570                 575     


Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly 
            580                 585                 590         


Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr 
        595                 600                 605             


Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His Ala Val 
    610                 615                 620                 


Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro 
625                 630                 635                 640 


Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln 
                645                 650                 655     


Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln 
            660                 665                 670         


Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr 
        675                 680                 685             


Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp 
    690                 695                 700                 


Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
705                 710                 715                 720 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                725                 730                 735     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            740                 745                 750         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        755                 760                 765             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    770                 775                 780                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
785                 790                 795                 800 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                805                 810                 815     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            820                 825                 830         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        835                 840                 845             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    850                 855                 860                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
865                 870                 875                 880 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                885                 890                 895     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            900                 905                 910         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        915                 920                 925             


Lys Ser Leu Ser Leu Ser Pro Gly 
    930                 935     


<210>  227
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4128 polypeptide

<400>  227

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr 
            420                 425                 430         


Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile 
        435                 440                 445             


Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp 
    450                 455                 460                 


Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu 
465                 470                 475                 480 


Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser 
                485                 490                 495     


Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln 
            500                 505                 510         


Ser Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val 
        515                 520                 525             


Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp 
    530                 535                 540                 


Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala 
545                 550                 555                 560 


Ala Asp Met Cys Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His 
                565                 570                 575     


Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp 
            580                 585                 590         


Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp 
        595                 600                 605             


Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala 
    610                 615                 620                 


Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu 
625                 630                 635                 640 


Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val 
                645                 650                 655     


Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val 
            660                 665                 670         


Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His 
        675                 680                 685             


Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly 
    690                 695                 700                 


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
705                 710                 715                 720 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                725                 730                 735     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            740                 745                 750         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        755                 760                 765             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    770                 775                 780                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
785                 790                 795                 800 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                805                 810                 815     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            820                 825                 830         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        835                 840                 845             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    850                 855                 860                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
865                 870                 875                 880 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                885                 890                 895     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            900                 905                 910         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        915                 920                 925             


Ser Pro Gly 
    930     


<210>  228
<211>  946
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4129 polypeptide

<400>  228

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe 
        435                 440                 445             


Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala 
    450                 455                 460                 


Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala 
465                 470                 475                 480 


Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly 
                485                 490                 495     


Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln 
            500                 505                 510         


Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser 
        515                 520                 525             


Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly 
    530                 535                 540                 


Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly 
545                 550                 555                 560 


Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala 
                565                 570                 575     


Asp Met Cys Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val 
            580                 585                 590         


Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu 
        595                 600                 605             


Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala 
    610                 615                 620                 


Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr 
625                 630                 635                 640 


Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr 
                645                 650                 655     


Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu 
            660                 665                 670         


Thr Arg Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val 
        675                 680                 685             


Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu 
    690                 695                 700                 


Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly 
705                 710                 715                 720 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
                725                 730                 735     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            740                 745                 750         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        755                 760                 765             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    770                 775                 780                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
785                 790                 795                 800 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                805                 810                 815     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            820                 825                 830         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        835                 840                 845             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    850                 855                 860                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
865                 870                 875                 880 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                885                 890                 895     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            900                 905                 910         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        915                 920                 925             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    930                 935                 940                 


Pro Gly 
945     


<210>  229
<211>  941
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4130 polypeptide

<400>  229

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser 
        435                 440                 445             


Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp 
    450                 455                 460                 


Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met 
465                 470                 475                 480 


Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp 
                485                 490                 495     


Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp 
            500                 505                 510         


Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His 
        515                 520                 525             


Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe 
    530                 535                 540                 


Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala 
545                 550                 555                 560 


Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln 
                565                 570                 575     


Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg 
            580                 585                 590         


Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu 
        595                 600                 605             


Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met 
    610                 615                 620                 


Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala 
625                 630                 635                 640 


Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly 
                645                 650                 655     


Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly 
            660                 665                 670         


Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln 
        675                 680                 685             


Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro 
    690                 695                 700                 


Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr 
705                 710                 715                 720 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
                725                 730                 735     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            740                 745                 750         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        755                 760                 765             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    770                 775                 780                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
785                 790                 795                 800 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                805                 810                 815     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            820                 825                 830         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        835                 840                 845             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    850                 855                 860                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
865                 870                 875                 880 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                885                 890                 895     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            900                 905                 910         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        915                 920                 925             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    930                 935                 940     


<210>  230
<211>  936
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4131 polypeptide

<400>  230

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser 
            420                 425                 430         


His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly 
        435                 440                 445             


Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val 
    450                 455                 460                 


Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro 
465                 470                 475                 480 


Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys 
                485                 490                 495     


Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg 
            500                 505                 510         


Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln Arg Met 
        515                 520                 525             


Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His 
    530                 535                 540                 


Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu 
545                 550                 555                 560 


Arg Ser Trp Thr Ala Ala Asp Met Cys Ala Gln Thr Thr Lys His Lys 
                565                 570                 575     


Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly 
            580                 585                 590         


Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr 
        595                 600                 605             


Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His Ala Val 
    610                 615                 620                 


Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro 
625                 630                 635                 640 


Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln 
                645                 650                 655     


Asp Thr Glu Leu Val Glu Thr Arg Pro Cys Gly Asp Gly Thr Phe Gln 
            660                 665                 670         


Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr 
        675                 680                 685             


Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp 
    690                 695                 700                 


Glu Ala Ala Ala Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
705                 710                 715                 720 


Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                725                 730                 735     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            740                 745                 750         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        755                 760                 765             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    770                 775                 780                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
785                 790                 795                 800 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                805                 810                 815     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            820                 825                 830         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        835                 840                 845             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    850                 855                 860                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
865                 870                 875                 880 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                885                 890                 895     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            900                 905                 910         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        915                 920                 925             


Lys Ser Leu Ser Leu Ser Pro Gly 
    930                 935     


<210>  231
<211>  931
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4132 polypeptide

<400>  231

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr 
            420                 425                 430         


Phe Phe Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile 
        435                 440                 445             


Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp 
    450                 455                 460                 


Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu 
465                 470                 475                 480 


Gly Pro Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser 
                485                 490                 495     


Gln Thr His Arg Val Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln 
            500                 505                 510         


Ser Glu Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val 
        515                 520                 525             


Gly Ser Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp 
    530                 535                 540                 


Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala 
545                 550                 555                 560 


Ala Asp Met Cys Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His 
                565                 570                 575     


Val Ala Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp 
            580                 585                 590         


Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp 
        595                 600                 605             


Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala 
    610                 615                 620                 


Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu 
625                 630                 635                 640 


Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val 
                645                 650                 655     


Glu Thr Arg Pro Cys Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val 
            660                 665                 670         


Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His 
        675                 680                 685             


Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly 
    690                 695                 700                 


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala 
705                 710                 715                 720 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                725                 730                 735     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            740                 745                 750         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        755                 760                 765             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    770                 775                 780                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
785                 790                 795                 800 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                805                 810                 815     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            820                 825                 830         


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        835                 840                 845             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    850                 855                 860                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
865                 870                 875                 880 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                885                 890                 895     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            900                 905                 910         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        915                 920                 925             


Ser Pro Gly 
    930     


<210>  232
<211>  926
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Construct 4133 polypeptide

<400>  232

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu Ala 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Ala Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr 
145                 150                 155                 160 


Lys Lys Thr Gln Leu Gln Leu Glu Ala Leu Leu Leu Asp Leu Gln Met 
                165                 170                 175     


Ile Leu Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met 
            180                 185                 190         


Leu Thr Ala Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His 
        195                 200                 205             


Leu Gln Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn 
    210                 215                 220                 


Leu Ala Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser 
225                 230                 235                 240 


Asn Ile Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe 
                245                 250                 255     


Met Cys Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn 
            260                 265                 270         


Arg Trp Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Cys His Pro 
305                 310                 315                 320 


Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe 
                325                 330                 335     


His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Cys Arg Ile 
            340                 345                 350         


Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe 
        355                 360                 365             


Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr 
    370                 375                 380                 


Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys 
385                 390                 395                 400 


Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val 
            420                 425                 430         


Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val 
        435                 440                 445             


Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg 
    450                 455                 460                 


Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp 
465                 470                 475                 480 


Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val 
                485                 490                 495     


Asp Leu Gly Thr Leu Arg Gly Cys Tyr Asn Gln Ser Glu Ala Gly Ser 
            500                 505                 510         


His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg 
        515                 520                 525             


Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile 
    530                 535                 540                 


Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Cys Ala 
545                 550                 555                 560 


Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu 
                565                 570                 575     


Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu 
            580                 585                 590         


Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His 
        595                 600                 605             


Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp 
    610                 615                 620                 


Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp 
625                 630                 635                 640 


Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Cys 
                645                 650                 655     


Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly 
            660                 665                 670         


Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys 
        675                 680                 685             


Pro Leu Thr Leu Arg Trp Glu Ala Ala Ala Gly Gly Asp Lys Thr His 
    690                 695                 700                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
705                 710                 715                 720 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                725                 730                 735     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            740                 745                 750         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        755                 760                 765             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    770                 775                 780                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
785                 790                 795                 800 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                805                 810                 815     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            820                 825                 830         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        835                 840                 845             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    850                 855                 860                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
865                 870                 875                 880 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                885                 890                 895     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            900                 905                 910         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        915                 920                 925     


<210>  233
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  binding peptide

<400>  233

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  234
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide

<400>  234

His Pro Val Gly Glu Ala Asp Tyr Phe 
1               5                   


<210>  235
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VETRP

<400>  235

Val Glu Thr Arg Pro 
1               5   


<210>  236
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GDGTF

<400>  236

Gly Asp Gly Thr Phe 
1               5   


<210>  237
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence within the carboxyl portion of the MHC-H alpha-1 
       polypeptide

<400>  237

Cys Tyr Asn Gln Ser Glu 
1               5       


<210>  238
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence within the MHC-H alpha-2-1 polypeptide


<220>
<221>  variant
<222>  (2)..(2)
<223>  Xaa is M or T

<400>  238

Asp Xaa Cys Ala Gln 
1               5   


