                               SEQUENCE LISTING

<110> PETRICHOR HEALTHCARE CAPITAL MANAGEMENT LP
 
<120> CYTOSOLIC PROTEIN TARGETING ENGINEERED DEUBIQUITINASES AND 
      METHODS OF USE THEREOF

<130> 723691-PHG-002PC

<140> PCT/US2021/058285
<141> 2021-11-05

<150> 63/110,622
<151> 2020-11-06

<160> 523   

<170> PatentIn version 3.5

<210> 1
<211> 438
<212> PRT
<213> Homo sapiens

<400> 1
Met Cys Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys 
1               5                   10                  15      


Glu Glu Gln Gly Glu Ala Leu Lys Leu Gln Ala Ser Thr Ser Thr Glu 
            20                  25                  30          


Val Ser His Gln Gln Cys Ser Val Pro Gly Leu Gly Glu Lys Phe Pro 
        35                  40                  45              


Thr Trp Glu Thr Thr Lys Pro Glu Leu Glu Leu Leu Gly His Asn Pro 
    50                  55                  60                  


Arg Arg Arg Arg Ile Thr Ser Ser Phe Thr Ile Gly Leu Arg Gly Leu 
65                  70                  75                  80  


Ile Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu 
                85                  90                  95      


Thr His Thr Pro Ile Leu Arg Asp Phe Phe Leu Ser Asp Arg His Arg 
            100                 105                 110         


Cys Glu Met Pro Ser Pro Glu Leu Cys Leu Val Cys Glu Met Ser Ser 
        115                 120                 125             


Leu Phe Arg Glu Leu Tyr Ser Gly Asn Pro Ser Pro His Val Pro Tyr 
    130                 135                 140                 


Lys Leu Leu His Leu Val Trp Ile His Ala Arg His Leu Ala Gly Tyr 
145                 150                 155                 160 


Arg Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp Val Leu 
                165                 170                 175     


His Arg His Cys Lys Gly Asp Asp Val Gly Lys Ala Ala Asn Asn Pro 
            180                 185                 190         


Asn His Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln 
        195                 200                 205             


Ser Asp Val Thr Cys Gln Ala Cys His Gly Val Ser Thr Thr Ile Asp 
    210                 215                 220                 


Pro Cys Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Thr Ser Phe 
225                 230                 235                 240 


Trp Pro Met Ser Pro Gly Arg Glu Ser Ser Val Asn Gly Glu Ser His 
                245                 250                 255     


Ile Pro Gly Ile Thr Thr Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg 
            260                 265                 270         


Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Gly Ser Cys Gln 
        275                 280                 285             


Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Asn Lys Leu Pro Val 
    290                 295                 300                 


Val Ala Cys Phe His Phe Lys Arg Phe Glu His Ser Ala Lys Gln Arg 
305                 310                 315                 320 


Arg Lys Ile Thr Thr Tyr Ile Ser Phe Pro Leu Glu Leu Asp Met Thr 
                325                 330                 335     


Pro Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly Gln Leu Gln 
            340                 345                 350         


Leu Pro Thr Asn Ser Gly Asn Asn Glu Asn Lys Tyr Ser Leu Phe Ala 
        355                 360                 365             


Val Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe 
    370                 375                 380                 


Ile Arg His His Lys Asp Gln Trp Phe Lys Cys Asp Asp Ala Val Ile 
385                 390                 395                 400 


Thr Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu 
                405                 410                 415     


Phe Tyr His Lys Gln Val Leu Glu His Glu Ser Glu Lys Val Lys Glu 
            420                 425                 430         


Met Asn Thr Gln Ala Tyr 
        435             


<210> 2
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys 
385                 390                 395                 400 


Pro Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu 
                405                 410                 415     


Val Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val 
            420                 425                 430         


Pro Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu 
        435                 440                 445             


Glu Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys 
    450                 455                 460                 


Gly Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro 
465                 470                 475                 480 


Ala Gly Ala Glu Pro Tyr Glu Phe Val Ser Leu Glu Trp Leu Gln Lys 
                485                 490                 495     


Trp Leu Asp Glu Ser Thr Pro Thr Lys Pro Ile Asp Asn His Ala Cys 
            500                 505                 510         


Leu Cys Ser His Asp Lys Leu His Pro Asp Lys Ile Ser Ile Met Lys 
        515                 520                 525             


Arg Ile Ser Glu Tyr Ala Ala Asp Ile Phe Tyr Ser Arg Tyr Gly Gly 
    530                 535                 540                 


Gly Pro Arg Leu Thr Val Lys Ala Leu Cys Lys Glu Cys Val Val Glu 
545                 550                 555                 560 


Arg Cys Arg Ile Leu Arg Leu Lys Asn Gln Leu Asn Glu Asp Tyr Lys 
                565                 570                 575     


Thr Val Asn Asn Leu Leu Lys Ala Ala Val Lys Gly Ser Asp Gly Phe 
            580                 585                 590         


Trp Val Gly Lys Ser Ser Leu Arg Ser Trp Arg Gln Leu Ala Leu Glu 
        595                 600                 605             


Gln Leu Asp Glu Gln Asp Gly Asp Ala Glu Gln Ser Asn Gly Lys Met 
    610                 615                 620                 


Asn Gly Ser Thr Leu Asn Lys Asp Glu Ser Lys Glu Glu Arg Lys Glu 
625                 630                 635                 640 


Glu Glu Glu Leu Asn Phe Asn Glu Asp Ile Leu Cys Pro His Gly Glu 
                645                 650                 655     


Leu Cys Ile Ser Glu Asn Glu Arg Arg Leu Val Ser Lys Glu Ala Trp 
            660                 665                 670         


Ser Lys Leu Gln Gln Tyr Phe Pro Lys Ala Pro Glu Phe Pro Ser Tyr 
        675                 680                 685             


Lys Glu Cys Cys Ser Gln Cys Lys Ile Leu Glu Arg Glu Gly Glu Glu 
    690                 695                 700                 


Asn Glu Ala Leu His Lys Met Ile Ala Asn Glu Gln Lys Thr Ser Leu 
705                 710                 715                 720 


Pro Asn Leu Phe Gln Asp Lys Asn Arg Pro Cys Leu Ser Asn Trp Pro 
                725                 730                 735     


Glu Asp Thr Asp Val Leu Tyr Ile Val Ser Gln Phe Phe Val Glu Glu 
            740                 745                 750         


Trp Arg Lys Phe Val Arg Lys Pro Thr Arg Cys Ser Pro Val Ser Ser 
        755                 760                 765             


Val Gly Asn Ser Ala Leu Leu Cys Pro His Gly Gly Leu Met Phe Thr 
    770                 775                 780                 


Phe Ala Ser Met Thr Lys Glu Asp Ser Lys Leu Ile Ala Leu Ile Trp 
785                 790                 795                 800 


Pro Ser Glu Trp Gln Met Ile Gln Lys Leu Phe Val Val Asp His Val 
                805                 810                 815     


Ile Lys Ile Thr Arg Ile Glu Val Gly Asp Val Asn Pro Ser Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ser Glu Pro Lys Leu Cys Pro Glu Cys Arg Glu Gly Leu 
        835                 840                 845             


Leu Cys Gln Gln Gln Arg Asp Leu Arg Glu Tyr Thr Gln Ala Thr Ile 
    850                 855                 860                 


Tyr Val His Lys Val Val Asp Asn Lys Lys Val Met Lys Asp Ser Ala 
865                 870                 875                 880 


Pro Glu Leu Asn Val Ser Ser Ser Glu Thr Glu Glu Asp Lys Glu Glu 
                885                 890                 895     


Ala Lys Pro Asp Gly Glu Lys Asp Pro Asp Phe Asn Gln Ser Asn Gly 
            900                 905                 910         


Gly Thr Lys Arg Gln Lys Ile Ser His Gln Asn Tyr Ile Ala Tyr Gln 
        915                 920                 925             


Lys Gln Val Ile Arg Arg Ser Met Arg His Arg Lys Val Arg Gly Glu 
    930                 935                 940                 


Lys Ala Leu Leu Val Ser Ala Asn Gln Thr Leu Lys Glu Leu Lys Ile 
945                 950                 955                 960 


Gln Ile Met His Ala Phe Ser Val Ala Pro Phe Asp Gln Asn Leu Ser 
                965                 970                 975     


Ile Asp Gly Lys Ile Leu Ser Asp Asp Cys Ala Thr Leu Gly Thr Leu 
            980                 985                 990         


Gly Val Ile Pro Glu Ser Val Ile  Leu Leu Lys Ala Asp  Glu Pro Ile 
        995                 1000                 1005             


Ala Asp  Tyr Ala Ala Met Asp  Asp Val Met Gln Val  Cys Met Pro 
    1010                 1015                 1020             


Glu Glu  Gly Phe Lys Gly Thr  Gly Leu Leu Gly His  
    1025                 1030                 1035 


<210> 3
<211> 520
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser 
1               5                   10                  15      


Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys 
            20                  25                  30          


Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His 
        35                  40                  45              


Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala 
    50                  55                  60                  


Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val 
65                  70                  75                  80  


Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr 
                85                  90                  95      


Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln 
            100                 105                 110         


Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala 
        115                 120                 125             


Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly 
145                 150                 155                 160 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser 
                165                 170                 175     


Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala 
            180                 185                 190         


Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr 
        195                 200                 205             


Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys 
    210                 215                 220                 


Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr 
                245                 250                 255     


Gln Gln Gln Asp Ala His Glu Phe Met Arg Tyr Leu Leu Asp His Leu 
            260                 265                 270         


His Leu Glu Leu Gln Gly Gly Phe Asn Gly Val Ser Arg Ser Ala Ile 
        275                 280                 285             


Leu Gln Glu Asn Ser Thr Leu Ser Ala Ser Asn Lys Cys Cys Ile Asn 
    290                 295                 300                 


Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln Asn 
305                 310                 315                 320 


Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys Arg 
            340                 345                 350         


Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu 
        355                 360                 365             


Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met 
    370                 375                 380                 


Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp Ile 
385                 390                 395                 400 


Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp 
                405                 410                 415     


Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu 
            420                 425                 430         


Arg Gly Leu Asp Met Lys Cys Tyr Leu Leu Glu Pro Glu Asn Ser Gly 
        435                 440                 445             


Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly 
    450                 455                 460                 


Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly 
465                 470                 475                 480 


Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu 
                485                 490                 495     


Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His Gln 
            500                 505                 510         


Ala Lys Ala Gly Ser Asp Lys Leu 
        515                 520 


<210> 4
<211> 470
<212> PRT
<213> Homo sapiens

<400> 4
Gln Leu Ala Pro Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala 
1               5                   10                  15      


Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
            20                  25                  30          


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
        35                  40                  45              


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
    50                  55                  60                  


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
65                  70                  75                  80  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
                85                  90                  95      


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
            100                 105                 110         


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
        115                 120                 125             


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
    130                 135                 140                 


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
145                 150                 155                 160 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
                165                 170                 175     


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
            180                 185                 190         


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
        195                 200                 205             


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
    210                 215                 220                 


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
225                 230                 235                 240 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
                245                 250                 255     


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
            260                 265                 270         


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
        275                 280                 285             


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
    290                 295                 300                 


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
305                 310                 315                 320 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
                325                 330                 335     


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
            340                 345                 350         


Pro Cys Leu Gln Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala 
        355                 360                 365             


Thr Gln Glu Ser Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn 
    370                 375                 380                 


Lys Thr Lys Pro Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro 
385                 390                 395                 400 


Pro Asp Val Leu Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys 
                405                 410                 415     


Asn His His Pro Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr 
            420                 425                 430         


Thr Pro Thr His Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu 
        435                 440                 445             


Arg Gly Arg Ala Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg 
    450                 455                 460                 


Ala Leu Leu Val Cys Gln 
465                 470 


<210> 5
<211> 785
<212> PRT
<213> Homo sapiens

<400> 5
Met Pro Gly Val Ile Pro Ser Glu Ser Asn Gly Leu Ser Arg Gly Ser 
1               5                   10                  15      


Pro Ser Lys Lys Asn Arg Leu Ser Leu Lys Phe Phe Gln Lys Lys Glu 
            20                  25                  30          


Thr Lys Arg Ala Leu Asp Phe Thr Asp Ser Gln Glu Asn Glu Glu Lys 
        35                  40                  45              


Ala Ser Glu Tyr Arg Ala Ser Glu Ile Asp Gln Val Val Pro Ala Ala 
    50                  55                  60                  


Gln Ser Ser Pro Ile Asn Cys Glu Lys Arg Glu Asn Leu Leu Pro Phe 
65                  70                  75                  80  


Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn Ser Ile Leu 
                85                  90                  95      


Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val Lys His Leu 
            100                 105                 110         


Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp Glu Ala Asn 
        115                 120                 125             


Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala Ser Tyr Glu 
    130                 135                 140                 


Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu Gln Leu Gln 
145                 150                 155                 160 


Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu Leu Ala Thr 
                165                 170                 175     


Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn Pro Met Tyr 
            180                 185                 190         


Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln Cys Ile Leu 
        195                 200                 205             


Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu Glu Val Lys 
    210                 215                 220                 


Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro His Pro Lys 
225                 230                 235                 240 


Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser Met Arg His 
                245                 250                 255     


Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly Lys Arg Lys 
            260                 265                 270         


Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys Leu Ser Lys 
        275                 280                 285             


Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg Ser Lys Arg 
    290                 295                 300                 


Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile Ile Pro Lys 
305                 310                 315                 320 


Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys Lys Ser Arg 
                325                 330                 335     


Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro Ser Ile Leu 
            340                 345                 350         


Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln Gly Val Lys 
        355                 360                 365             


Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp Leu Gly Lys 
    370                 375                 380                 


Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu Ser Pro Gly 
385                 390                 395                 400 


Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro Ile Asn Lys 
                405                 410                 415     


Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu Phe Gln Gly 
            420                 425                 430         


Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser Leu Thr Glu 
        435                 440                 445             


Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln Glu Asp Glu 
    450                 455                 460                 


Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu Pro Lys Thr 
465                 470                 475                 480 


Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala Ser Val Glu 
                485                 490                 495     


Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys His His Tyr 
            500                 505                 510         


Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro Glu Val Ile 
        515                 520                 525             


Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu Phe Asp Cys 
    530                 535                 540                 


Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu Thr Pro Leu 
545                 550                 555                 560 


Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn Asp Ser Tyr 
                565                 570                 575     


Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile Ser Ser Gly 
            580                 585                 590         


His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser Leu Glu Leu 
        595                 600                 605             


Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Ile Gly Lys Pro 
    610                 615                 620                 


Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu Asn Tyr Asn 
625                 630                 635                 640 


Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln Pro Ser Lys 
                645                 650                 655     


Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu Gly Gly Gln 
            660                 665                 670         


Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser Asn Pro Asp 
        675                 680                 685             


Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser Glu Thr Ser 
    690                 695                 700                 


Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu Ser Ser Asp 
705                 710                 715                 720 


Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile Ser Tyr Val 
                725                 730                 735     


Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu Phe Asp Asp 
            740                 745                 750         


Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn Ser Leu Ser 
        755                 760                 765             


Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe Tyr Lys Lys 
    770                 775                 780                 


Leu 
785 


<210> 6
<211> 1235
<212> PRT
<213> Homo sapiens

<400> 6
Met Phe Gly Asp Leu Phe Glu Glu Glu Tyr Ser Thr Val Ser Asn Asn 
1               5                   10                  15      


Gln Tyr Gly Lys Gly Lys Lys Leu Lys Thr Lys Ala Leu Glu Pro Pro 
            20                  25                  30          


Ala Pro Arg Glu Phe Thr Asn Leu Ser Gly Ile Arg Asn Gln Gly Gly 
        35                  40                  45              


Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu His Phe Thr Pro Glu 
    50                  55                  60                  


Phe Arg Glu Ala Leu Phe Ser Leu Gly Pro Glu Glu Leu Gly Leu Phe 
65                  70                  75                  80  


Glu Asp Lys Asp Lys Pro Asp Ala Lys Val Arg Ile Ile Pro Leu Gln 
                85                  90                  95      


Leu Gln Arg Leu Phe Ala Gln Leu Leu Leu Leu Asp Gln Glu Ala Ala 
            100                 105                 110         


Ser Thr Ala Asp Leu Thr Asp Ser Phe Gly Trp Thr Ser Asn Glu Glu 
        115                 120                 125             


Met Arg Gln His Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala 
    130                 135                 140                 


Leu Glu Thr Ser Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg 
145                 150                 155                 160 


Leu Tyr His Gly Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys 
                165                 170                 175     


Asn Val Ser Glu Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val 
            180                 185                 190         


Lys Asn Val Ser Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu 
        195                 200                 205             


Glu Glu Val Phe Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp 
    210                 215                 220                 


Arg Leu Val Lys Ala Ala Lys Ser Ala Lys Leu Arg Lys Leu Pro Pro 
225                 230                 235                 240 


Phe Leu Thr Val Ser Leu Leu Arg Phe Asn Phe Asp Phe Val Lys Cys 
                245                 250                 255     


Glu Arg Tyr Lys Glu Thr Ser Cys Tyr Thr Phe Pro Leu Arg Ile Asn 
            260                 265                 270         


Leu Lys Pro Phe Cys Glu Gln Ser Glu Leu Asp Asp Leu Glu Tyr Ile 
        275                 280                 285             


Tyr Asp Leu Phe Ser Val Ile Ile His Lys Gly Gly Cys Tyr Gly Gly 
    290                 295                 300                 


His Tyr His Val Tyr Ile Lys Asp Val Asp His Leu Gly Asn Trp Gln 
305                 310                 315                 320 


Phe Gln Glu Glu Lys Ser Lys Pro Asp Val Asn Leu Lys Asp Leu Gln 
                325                 330                 335     


Ser Glu Glu Glu Ile Asp His Pro Leu Met Ile Leu Lys Ala Ile Leu 
            340                 345                 350         


Leu Glu Glu Asn Asn Leu Ile Pro Val Asp Gln Leu Gly Gln Lys Leu 
        355                 360                 365             


Leu Lys Lys Ile Gly Ile Ser Trp Asn Lys Lys Tyr Arg Lys Gln His 
    370                 375                 380                 


Gly Pro Leu Arg Lys Phe Leu Gln Leu His Ser Gln Ile Phe Leu Leu 
385                 390                 395                 400 


Ser Ser Asp Glu Ser Thr Val Arg Leu Leu Lys Asn Ser Ser Leu Gln 
                405                 410                 415     


Ala Glu Ser Asp Phe Gln Arg Asn Asp Gln Gln Ile Phe Lys Met Leu 
            420                 425                 430         


Pro Pro Glu Ser Pro Gly Leu Asn Asn Ser Ile Ser Cys Pro His Trp 
        435                 440                 445             


Phe Asp Ile Asn Asp Ser Lys Val Gln Pro Ile Arg Glu Lys Asp Ile 
    450                 455                 460                 


Glu Gln Gln Phe Gln Gly Lys Glu Ser Ala Tyr Met Leu Phe Tyr Arg 
465                 470                 475                 480 


Lys Ser Gln Leu Gln Arg Pro Pro Glu Ala Arg Ala Asn Pro Arg Tyr 
                485                 490                 495     


Gly Val Pro Cys His Leu Leu Asn Glu Met Asp Ala Ala Asn Ile Glu 
            500                 505                 510         


Leu Gln Thr Lys Arg Ala Glu Cys Asp Ser Ala Asn Asn Thr Phe Glu 
        515                 520                 525             


Leu His Leu His Leu Gly Pro Gln Tyr His Phe Phe Asn Gly Ala Leu 
    530                 535                 540                 


His Pro Val Val Ser Gln Thr Glu Ser Val Trp Asp Leu Thr Phe Asp 
545                 550                 555                 560 


Lys Arg Lys Thr Leu Gly Asp Leu Arg Gln Ser Ile Phe Gln Leu Leu 
                565                 570                 575     


Glu Phe Trp Glu Gly Asp Met Val Leu Ser Val Ala Lys Leu Val Pro 
            580                 585                 590         


Ala Gly Leu His Ile Tyr Gln Ser Leu Gly Gly Asp Glu Leu Thr Leu 
        595                 600                 605             


Cys Glu Thr Glu Ile Ala Asp Gly Glu Asp Ile Phe Val Trp Asn Gly 
    610                 615                 620                 


Val Glu Val Gly Gly Val His Ile Gln Thr Gly Ile Asp Cys Glu Pro 
625                 630                 635                 640 


Leu Leu Leu Asn Val Leu His Leu Asp Thr Ser Ser Asp Gly Glu Lys 
                645                 650                 655     


Cys Cys Gln Val Ile Glu Ser Pro His Val Phe Pro Ala Asn Ala Glu 
            660                 665                 670         


Val Gly Thr Val Leu Thr Ala Leu Ala Ile Pro Ala Gly Val Ile Phe 
        675                 680                 685             


Ile Asn Ser Ala Gly Cys Pro Gly Gly Glu Gly Trp Thr Ala Ile Pro 
    690                 695                 700                 


Lys Glu Asp Met Arg Lys Thr Phe Arg Glu Gln Gly Leu Arg Asn Gly 
705                 710                 715                 720 


Ser Ser Ile Leu Ile Gln Asp Ser His Asp Asp Asn Ser Leu Leu Thr 
                725                 730                 735     


Lys Glu Glu Lys Trp Val Thr Ser Met Asn Glu Ile Asp Trp Leu His 
            740                 745                 750         


Val Lys Asn Leu Cys Gln Leu Glu Ser Glu Glu Lys Gln Val Lys Ile 
        755                 760                 765             


Ser Ala Thr Val Asn Thr Met Val Phe Asp Ile Arg Ile Lys Ala Ile 
    770                 775                 780                 


Lys Glu Leu Lys Leu Met Lys Glu Leu Ala Asp Asn Ser Cys Leu Arg 
785                 790                 795                 800 


Pro Ile Asp Arg Asn Gly Lys Leu Leu Cys Pro Val Pro Asp Ser Tyr 
                805                 810                 815     


Thr Leu Lys Glu Ala Glu Leu Lys Met Gly Ser Ser Leu Gly Leu Cys 
            820                 825                 830         


Leu Gly Lys Ala Pro Ser Ser Ser Gln Leu Phe Leu Phe Phe Ala Met 
        835                 840                 845             


Gly Ser Asp Val Gln Pro Gly Thr Glu Met Glu Ile Val Val Glu Glu 
    850                 855                 860                 


Thr Ile Ser Val Arg Asp Cys Leu Lys Leu Met Leu Lys Lys Ser Gly 
865                 870                 875                 880 


Leu Gln Gly Asp Ala Trp His Leu Arg Lys Met Asp Trp Cys Tyr Glu 
                885                 890                 895     


Ala Gly Glu Pro Leu Cys Glu Glu Asp Ala Thr Leu Lys Glu Leu Leu 
            900                 905                 910         


Ile Cys Ser Gly Asp Thr Leu Leu Leu Ile Glu Gly Gln Leu Pro Pro 
        915                 920                 925             


Leu Gly Phe Leu Lys Val Pro Ile Trp Trp Tyr Gln Leu Gln Gly Pro 
    930                 935                 940                 


Ser Gly His Trp Glu Ser His Gln Asp Gln Thr Asn Cys Thr Ser Ser 
945                 950                 955                 960 


Trp Gly Arg Val Trp Arg Ala Thr Ser Ser Gln Gly Ala Ser Gly Asn 
                965                 970                 975     


Glu Pro Ala Gln Val Ser Leu Leu Tyr Leu Gly Asp Ile Glu Ile Ser 
            980                 985                 990         


Glu Asp Ala Thr Leu Ala Glu Leu  Lys Ser Gln Ala Met  Thr Leu Pro 
        995                 1000                 1005             


Pro Phe  Leu Glu Phe Gly Val  Pro Ser Pro Ala His  Leu Arg Ala 
    1010                 1015                 1020             


Trp Thr  Val Glu Arg Lys Arg  Pro Gly Arg Leu Leu  Arg Thr Asp 
    1025                 1030                 1035             


Arg Gln  Pro Leu Arg Glu Tyr  Lys Leu Gly Arg Arg  Ile Glu Ile 
    1040                 1045                 1050             


Cys Leu  Glu Pro Leu Gln Lys  Gly Glu Asn Leu Gly  Pro Gln Asp 
    1055                 1060                 1065             


Val Leu  Leu Arg Thr Gln Val  Arg Ile Pro Gly Glu  Arg Thr Tyr 
    1070                 1075                 1080             


Ala Pro  Ala Leu Asp Leu Val  Trp Asn Ala Ala Gln  Gly Gly Thr 
    1085                 1090                 1095             


Ala Gly  Ser Leu Arg Gln Arg  Val Ala Asp Phe Tyr  Arg Leu Pro 
    1100                 1105                 1110             


Val Glu  Lys Ile Glu Ile Ala  Lys Tyr Phe Pro Glu  Lys Phe Glu 
    1115                 1120                 1125             


Trp Leu  Pro Ile Ser Ser Trp  Asn Gln Gln Ile Thr  Lys Arg Lys 
    1130                 1135                 1140             


Lys Lys  Lys Lys Gln Asp Tyr  Leu Gln Gly Ala Pro  Tyr Tyr Leu 
    1145                 1150                 1155             


Lys Asp  Gly Asp Thr Ile Gly  Val Lys Asn Leu Leu  Ile Asp Asp 
    1160                 1165                 1170             


Asp Asp  Asp Phe Ser Thr Ile  Arg Asp Asp Thr Gly  Lys Glu Lys 
    1175                 1180                 1185             


Gln Lys  Gln Arg Ala Leu Gly  Arg Arg Lys Ser Gln  Glu Ala Leu 
    1190                 1195                 1200             


His Glu  Gln Ser Ser Tyr Ile  Leu Ser Ser Ala Glu  Thr Pro Ala 
    1205                 1210                 1215             


Arg Pro  Arg Ala Pro Glu Thr  Ser Leu Ser Ile His  Val Gly Ser 
    1220                 1225                 1230             


Phe Arg  
    1235 


<210> 7
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 7
Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln 
1               5                   10                  15      


Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp 
            20                  25                  30          


Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu 
        35                  40                  45              


Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser 
    50                  55                  60                  


Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg 
65                  70                  75                  80  


Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro 
                85                  90                  95      


Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln 
            100                 105                 110         


Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr 
        115                 120                 125             


Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg 
    130                 135                 140                 


Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His 
145                 150                 155                 160 


Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val 
                165                 170                 175     


Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu 
            180                 185                 190         


Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys 
        195                 200                 205             


Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr 
    210                 215                 220                 


Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys 
225                 230                 235                 240 


Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val 
                245                 250                 255     


Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys 
            260                 265                 270         


Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu 
        275                 280                 285             


Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu 
    290                 295                 300                 


Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu 
                325                 330                 335     


Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu 
            340                 345                 350         


Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val 
        355                 360                 365             


Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His 
    370                 375                 380                 


Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro 
385                 390                 395                 400 


Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp 
                405                 410                 415     


Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro 
            420                 425                 430         


Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr 
        435                 440                 445             


Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His 
    450                 455                 460                 


Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe 
465                 470                 475                 480 


Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His 
                485                 490                 495     


Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn 
            500                 505                 510         


Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu 
        515                 520                 525             


Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu 
    530                 535                 540                 


Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu 
545                 550                 555                 560 


Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys 
                565                 570                 575     


Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr 
            580                 585                 590         


Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser 
        595                 600                 605             


Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro 
    610                 615                 620                 


Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn 
625                 630                 635                 640 


Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn 
                645                 650                 655     


Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser 
            660                 665                 670         


Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe 
        675                 680                 685             


Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His 
    690                 695                 700                 


Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met 
705                 710                 715                 720 


Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu 
                725                 730                 735     


Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser 
            740                 745                 750         


Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe 
        755                 760                 765             


Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys 
    770                 775                 780                 


Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp 
785                 790                 795                 800 


Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg 
                805                 810                 815     


Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr 
            820                 825                 830         


Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly 
        835                 840                 845             


Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu 
    850                 855                 860                 


Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln 
865                 870                 875                 880 


Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys 
                885                 890                 895     


Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro 
            900                 905                 910         


Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala 
        915                 920                 925             


Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile 
    930                 935                 940                 


Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu 
945                 950                 955                 960 


Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro 
                965                 970                 975     


Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val 
            980                 985                 990         


Ala His Phe His Lys Glu Val Phe  Gly Thr Phe Gly Ile  Pro Phe Leu 
        995                 1000                 1005             


Leu Arg  Ile His Gln Gly Glu  His Phe Arg Glu Val  Met Lys Arg 
    1010                 1015                 1020             


Ile Gln  Ser Leu Leu Asp Ile  Gln Glu Lys Glu Phe  Glu Lys Phe 
    1025                 1030                 1035             


Lys Phe  Ala Ile Val Met Met  Gly Arg His Gln Tyr  Ile Asn Glu 
    1040                 1045                 1050             


Asp Glu  Tyr Glu Val Asn Leu  Lys Asp Phe Glu Pro  Gln Pro Gly 
    1055                 1060                 1065             


Asn Met  Ser His Pro Arg Pro  Trp Leu Gly Leu Asp  His Phe Asn 
    1070                 1075                 1080             


Lys Ala  Pro Lys Arg Ser Arg  Tyr Thr Tyr Leu Glu  Lys Ala Ile 
    1085                 1090                 1095             


Lys Ile  His Asn 
    1100         


<210> 8
<211> 530
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Ala Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 9
<211> 530
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Asn Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr Leu Leu Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 10
<211> 530
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Pro Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Lys Pro Pro Leu Ala Asn Tyr Met Leu Phe Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Ile Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Arg Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp Arg His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Asn Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Pro Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Ser 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Val Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Arg Val Glu Gly Thr Val Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Arg Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 11
<211> 358
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Gly Val Leu Phe Arg Ala His Gln Cys Gln Tyr Val His Pro 
1               5                   10                  15      


Cys Val His Val Tyr Val Thr Val Gly Leu Met Asp Pro Leu Cys Glu 
            20                  25                  30          


Arg Lys Glu Lys Ala Ser Lys Gln Glu Arg Glu Asn Pro Leu Ala His 
        35                  40                  45              


Leu Ala Ala Trp Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Ala 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Trp Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Tyr Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Ala Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Met Ile Arg Met Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Leu Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Arg Leu Ser Phe Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp 
        355             


<210> 12
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 12
Met Asp Lys Ile Leu Glu Gly Leu Val Ser Ser Ser His Pro Leu Pro 
1               5                   10                  15      


Leu Lys Arg Val Ile Val Arg Lys Val Val Glu Ser Ala Glu His Trp 
            20                  25                  30          


Leu Asp Glu Ala Gln Cys Glu Ala Met Phe Asp Leu Thr Thr Arg Leu 
        35                  40                  45              


Ile Leu Glu Gly Gln Asp Pro Phe Gln Arg Gln Val Gly His Gln Val 
    50                  55                  60                  


Leu Glu Ala Tyr Ala Arg Tyr His Arg Pro Glu Phe Glu Ser Phe Phe 
65                  70                  75                  80  


Asn Lys Thr Phe Val Leu Gly Leu Leu His Gln Gly Tyr His Ser Leu 
                85                  90                  95      


Asp Arg Lys Asp Val Ala Ile Leu Asp Tyr Ile His Asn Gly Leu Lys 
            100                 105                 110         


Leu Ile Met Ser Cys Pro Ser Val Leu Asp Leu Phe Ser Leu Leu Gln 
        115                 120                 125             


Val Glu Val Leu Arg Met Val Cys Glu Arg Pro Glu Pro Gln Leu Cys 
    130                 135                 140                 


Ala Arg Leu Ser Asp Leu Leu Thr Asp Phe Val Gln Cys Ile Pro Lys 
145                 150                 155                 160 


Gly Lys Leu Ser Ile Thr Phe Cys Gln Gln Leu Val Arg Thr Ile Gly 
                165                 170                 175     


His Phe Gln Cys Val Ser Thr Gln Glu Arg Glu Leu Arg Glu Tyr Val 
            180                 185                 190         


Ser Gln Val Thr Lys Val Ser Asn Leu Leu Gln Asn Ile Trp Lys Ala 
        195                 200                 205             


Glu Pro Ala Thr Leu Leu Pro Ser Leu Gln Glu Val Phe Ala Ser Ile 
    210                 215                 220                 


Ser Ser Thr Asp Ala Ser Phe Glu Pro Ser Val Ala Leu Ala Ser Leu 
225                 230                 235                 240 


Val Gln His Ile Pro Leu Gln Met Ile Thr Val Leu Ile Arg Ser Leu 
                245                 250                 255     


Thr Thr Asp Pro Asn Val Lys Asp Ala Ser Met Thr Gln Ala Leu Cys 
            260                 265                 270         


Arg Met Ile Asp Trp Leu Ser Trp Pro Leu Ala Gln His Val Asp Thr 
        275                 280                 285             


Trp Val Ile Ala Leu Leu Lys Gly Leu Ala Ala Val Gln Lys Phe Thr 
    290                 295                 300                 


Ile Leu Ile Asp Val Thr Leu Leu Lys Ile Glu Leu Val Phe Asn Arg 
305                 310                 315                 320 


Leu Trp Phe Pro Leu Val Arg Pro Gly Ala Leu Ala Val Leu Ser His 
                325                 330                 335     


Met Leu Leu Ser Phe Gln His Ser Pro Glu Ala Phe His Leu Ile Val 
            340                 345                 350         


Pro His Val Val Asn Leu Val His Ser Phe Lys Asn Asp Gly Leu Pro 
        355                 360                 365             


Ser Ser Thr Ala Phe Leu Val Gln Leu Thr Glu Leu Ile His Cys Met 
    370                 375                 380                 


Met Tyr His Tyr Ser Gly Phe Pro Asp Leu Tyr Glu Pro Ile Leu Glu 
385                 390                 395                 400 


Ala Ile Lys Asp Phe Pro Lys Pro Ser Glu Glu Lys Ile Lys Leu Ile 
                405                 410                 415     


Leu Asn Gln Ser Ala Trp Thr Ser Gln Ser Asn Ser Leu Ala Ser Cys 
            420                 425                 430         


Leu Ser Arg Leu Ser Gly Lys Ser Glu Thr Gly Lys Thr Gly Leu Ile 
        435                 440                 445             


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Val Ile Gln Ala Leu Phe 
    450                 455                 460                 


Met Ala Thr Asp Phe Arg Arg Gln Val Leu Ser Leu Asn Leu Asn Gly 
465                 470                 475                 480 


Cys Asn Ser Leu Met Lys Lys Leu Gln His Leu Phe Ala Phe Leu Ala 
                485                 490                 495     


His Thr Gln Arg Glu Ala Tyr Ala Pro Arg Ile Phe Phe Glu Ala Ser 
            500                 505                 510         


Arg Pro Pro Trp Phe Thr Pro Arg Ser Gln Gln Asp Cys Ser Glu Tyr 
        515                 520                 525             


Leu Arg Phe Leu Leu Asp Arg Leu His Glu Glu Glu Lys Ile Leu Lys 
    530                 535                 540                 


Val Gln Ala Ser His Lys Pro Ser Glu Ile Leu Glu Cys Ser Glu Thr 
545                 550                 555                 560 


Ser Leu Gln Glu Val Ala Ser Lys Ala Ala Val Leu Thr Glu Thr Pro 
                565                 570                 575     


Arg Thr Ser Asp Gly Glu Lys Thr Leu Ile Glu Lys Met Phe Gly Gly 
            580                 585                 590         


Lys Leu Arg Thr His Ile Arg Cys Leu Asn Cys Arg Ser Thr Ser Gln 
        595                 600                 605             


Lys Val Glu Ala Phe Thr Asp Leu Ser Leu Ala Phe Cys Pro Ser Ser 
    610                 615                 620                 


Ser Leu Glu Asn Met Ser Val Gln Asp Pro Ala Ser Ser Pro Ser Ile 
625                 630                 635                 640 


Gln Asp Gly Gly Leu Met Gln Ala Ser Val Pro Gly Pro Ser Glu Glu 
                645                 650                 655     


Pro Val Val Tyr Asn Pro Thr Thr Ala Ala Phe Ile Cys Asp Ser Leu 
            660                 665                 670         


Val Asn Glu Lys Thr Ile Gly Ser Pro Pro Asn Glu Phe Tyr Cys Ser 
        675                 680                 685             


Glu Asn Thr Ser Val Pro Asn Glu Ser Asn Lys Ile Leu Val Asn Lys 
    690                 695                 700                 


Asp Val Pro Gln Lys Pro Gly Gly Glu Thr Thr Pro Ser Val Thr Asp 
705                 710                 715                 720 


Leu Leu Asn Tyr Phe Leu Ala Pro Glu Ile Leu Thr Gly Asp Asn Gln 
                725                 730                 735     


Tyr Tyr Cys Glu Asn Cys Ala Ser Leu Gln Asn Ala Glu Lys Thr Met 
            740                 745                 750         


Gln Ile Thr Glu Glu Pro Glu Tyr Leu Ile Leu Thr Leu Leu Arg Phe 
        755                 760                 765             


Ser Tyr Asp Gln Lys Tyr His Val Arg Arg Lys Ile Leu Asp Asn Val 
    770                 775                 780                 


Ser Leu Pro Leu Val Leu Glu Leu Pro Val Lys Arg Ile Thr Ser Phe 
785                 790                 795                 800 


Ser Ser Leu Ser Glu Ser Trp Ser Val Asp Val Asp Phe Thr Asp Leu 
                805                 810                 815     


Ser Glu Asn Leu Ala Lys Lys Leu Lys Pro Ser Gly Thr Asp Glu Ala 
            820                 825                 830         


Ser Cys Thr Lys Leu Val Pro Tyr Leu Leu Ser Ser Val Val Val His 
        835                 840                 845             


Ser Gly Ile Ser Ser Glu Ser Gly His Tyr Tyr Ser Tyr Ala Arg Asn 
    850                 855                 860                 


Ile Thr Ser Thr Asp Ser Ser Tyr Gln Met Tyr His Gln Ser Glu Ala 
865                 870                 875                 880 


Leu Ala Leu Ala Ser Ser Gln Ser His Leu Leu Gly Arg Asp Ser Pro 
                885                 890                 895     


Ser Ala Val Phe Glu Gln Asp Leu Glu Asn Lys Glu Met Ser Lys Glu 
            900                 905                 910         


Trp Phe Leu Phe Asn Asp Ser Arg Val Thr Phe Thr Ser Phe Gln Ser 
        915                 920                 925             


Val Gln Lys Ile Thr Ser Arg Phe Pro Lys Asp Thr Ala Tyr Val Leu 
    930                 935                 940                 


Leu Tyr Lys Lys Gln His Ser Thr Asn Gly Leu Ser Gly Asn Asn Pro 
945                 950                 955                 960 


Thr Ser Gly Leu Trp Ile Asn Gly Asp Pro Pro Leu Gln Lys Glu Leu 
                965                 970                 975     


Met Asp Ala Ile Thr Lys Asp Asn Lys Leu Tyr Leu Gln Glu Gln Glu 
            980                 985                 990         


Leu Asn Ala Arg Ala Arg Ala Leu  Gln Ala Ala Ser Ala  Ser Cys Ser 
        995                 1000                 1005             


Phe Arg  Pro Asn Gly Phe Asp  Asp Asn Asp Pro Pro  Gly Ser Cys 
    1010                 1015                 1020             


Gly Pro  Thr Gly Gly Gly Gly  Gly Gly Gly Phe Asn  Thr Val Gly 
    1025                 1030                 1035             


Arg Leu  Val Phe 
    1040         


<210> 13
<211> 1123
<212> PRT
<213> Homo sapiens

<400> 13
Met Asp Leu Gly Pro Gly Asp Ala Ala Gly Gly Gly Pro Leu Ala Pro 
1               5                   10                  15      


Arg Pro Arg Arg Arg Arg Ser Leu Arg Arg Leu Phe Ser Arg Phe Leu 
            20                  25                  30          


Leu Ala Leu Gly Ser Arg Ser Arg Pro Gly Asp Ser Pro Pro Arg Pro 
        35                  40                  45              


Gln Pro Gly His Cys Asp Gly Asp Gly Glu Gly Gly Phe Ala Cys Ala 
    50                  55                  60                  


Pro Gly Pro Val Pro Ala Ala Pro Gly Ser Pro Gly Glu Glu Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Gln Pro Gln Leu Gln Leu Pro Ala Gly Asp Gly Ala Arg 
                85                  90                  95      


Pro Pro Gly Ala Gln Gly Leu Lys Asn His Gly Asn Thr Cys Phe Met 
            100                 105                 110         


Asn Ala Val Val Gln Cys Leu Ser Asn Thr Asp Leu Leu Ala Glu Phe 
        115                 120                 125             


Leu Ala Leu Gly Arg Tyr Arg Ala Ala Pro Gly Arg Ala Glu Val Thr 
    130                 135                 140                 


Glu Gln Leu Ala Ala Leu Val Arg Ala Leu Trp Thr Arg Glu Tyr Thr 
145                 150                 155                 160 


Pro Gln Leu Ser Ala Glu Phe Lys Asn Ala Val Ser Lys Tyr Gly Ser 
                165                 170                 175     


Gln Phe Gln Gly Asn Ser Gln His Asp Ala Leu Glu Phe Leu Leu Trp 
            180                 185                 190         


Leu Leu Asp Arg Val His Glu Asp Leu Glu Gly Ser Ser Arg Gly Pro 
        195                 200                 205             


Val Ser Glu Lys Leu Pro Pro Glu Ala Thr Lys Thr Ser Glu Asn Cys 
    210                 215                 220                 


Leu Ser Pro Ser Ala Gln Leu Pro Leu Gly Gln Ser Phe Val Gln Ser 
225                 230                 235                 240 


His Phe Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys Leu 
                245                 250                 255     


Lys Gln Ser Asn Thr Phe Asp Pro Phe Leu Cys Val Ser Leu Pro Ile 
            260                 265                 270         


Pro Leu Arg Gln Thr Arg Phe Leu Ser Val Thr Leu Val Phe Pro Ser 
        275                 280                 285             


Lys Ser Gln Arg Phe Leu Arg Val Gly Leu Ala Val Pro Ile Leu Ser 
    290                 295                 300                 


Thr Val Ala Ala Leu Arg Lys Met Val Ala Glu Glu Gly Gly Val Pro 
305                 310                 315                 320 


Ala Asp Glu Val Ile Leu Val Glu Leu Tyr Pro Ser Gly Phe Gln Arg 
                325                 330                 335     


Ser Phe Phe Asp Glu Glu Asp Leu Asn Thr Ile Ala Glu Gly Asp Asn 
            340                 345                 350         


Val Tyr Ala Phe Gln Val Pro Pro Ser Pro Ser Gln Gly Thr Leu Ser 
        355                 360                 365             


Ala His Pro Leu Gly Leu Ser Ala Ser Pro Arg Leu Ala Ala Arg Glu 
    370                 375                 380                 


Gly Gln Arg Phe Ser Leu Ser Leu His Ser Glu Ser Lys Val Leu Ile 
385                 390                 395                 400 


Leu Phe Cys Asn Leu Val Gly Ser Gly Gln Gln Ala Ser Arg Phe Gly 
                405                 410                 415     


Pro Pro Phe Leu Ile Arg Glu Asp Arg Ala Val Ser Trp Ala Gln Leu 
            420                 425                 430         


Gln Gln Ser Ile Leu Ser Lys Val Arg His Leu Met Lys Ser Glu Ala 
        435                 440                 445             


Pro Val Gln Asn Leu Gly Ser Leu Phe Ser Ile Arg Val Val Gly Leu 
    450                 455                 460                 


Ser Val Ala Cys Ser Tyr Leu Ser Pro Lys Asp Ser Arg Pro Leu Cys 
465                 470                 475                 480 


His Trp Ala Val Asp Arg Val Leu His Leu Arg Arg Pro Gly Gly Pro 
                485                 490                 495     


Pro His Val Lys Leu Ala Val Glu Trp Asp Ser Ser Val Lys Glu Arg 
            500                 505                 510         


Leu Phe Gly Ser Leu Gln Glu Glu Arg Ala Gln Asp Ala Asp Ser Val 
        515                 520                 525             


Trp Gln Gln Gln Gln Ala His Gln Gln His Ser Cys Thr Leu Asp Glu 
    530                 535                 540                 


Cys Phe Gln Phe Tyr Thr Lys Glu Glu Gln Leu Ala Gln Asp Asp Ala 
545                 550                 555                 560 


Trp Lys Cys Pro His Cys Gln Val Leu Gln Gln Gly Met Val Lys Leu 
                565                 570                 575     


Ser Leu Trp Thr Leu Pro Asp Ile Leu Ile Ile His Leu Lys Arg Phe 
            580                 585                 590         


Cys Gln Val Gly Glu Arg Arg Asn Lys Leu Ser Thr Leu Val Lys Phe 
        595                 600                 605             


Pro Leu Ser Gly Leu Asn Met Ala Pro His Val Ala Gln Arg Ser Thr 
    610                 615                 620                 


Ser Pro Glu Ala Gly Leu Gly Pro Trp Pro Ser Trp Lys Gln Pro Asp 
625                 630                 635                 640 


Cys Leu Pro Thr Ser Tyr Pro Leu Asp Phe Leu Tyr Asp Leu Tyr Ala 
                645                 650                 655     


Val Cys Asn His His Gly Asn Leu Gln Gly Gly His Tyr Thr Ala Tyr 
            660                 665                 670         


Cys Arg Asn Ser Leu Asp Gly Gln Trp Tyr Ser Tyr Asp Asp Ser Thr 
        675                 680                 685             


Val Glu Pro Leu Arg Glu Asp Glu Val Asn Thr Arg Gly Ala Tyr Ile 
    690                 695                 700                 


Leu Phe Tyr Gln Lys Arg Asn Ser Ile Pro Pro Trp Ser Ala Ser Ser 
705                 710                 715                 720 


Ser Met Arg Gly Ser Thr Ser Ser Ser Leu Ser Asp His Trp Leu Leu 
                725                 730                 735     


Arg Leu Gly Ser His Ala Gly Ser Thr Arg Gly Ser Leu Leu Ser Trp 
            740                 745                 750         


Ser Ser Ala Pro Cys Pro Ser Leu Pro Gln Val Pro Asp Ser Pro Ile 
        755                 760                 765             


Phe Thr Asn Ser Leu Cys Asn Gln Glu Lys Gly Gly Leu Glu Pro Arg 
    770                 775                 780                 


Arg Leu Val Arg Gly Val Lys Gly Arg Ser Ile Ser Met Lys Ala Pro 
785                 790                 795                 800 


Thr Thr Ser Arg Ala Lys Gln Gly Pro Phe Lys Thr Met Pro Leu Arg 
                805                 810                 815     


Trp Ser Phe Gly Ser Lys Glu Lys Pro Pro Gly Ala Ser Val Glu Leu 
            820                 825                 830         


Val Glu Tyr Leu Glu Ser Arg Arg Arg Pro Arg Ser Thr Ser Gln Ser 
        835                 840                 845             


Ile Val Ser Leu Leu Thr Gly Thr Ala Gly Glu Asp Glu Lys Ser Ala 
    850                 855                 860                 


Ser Pro Arg Ser Asn Val Ala Leu Pro Ala Asn Ser Glu Asp Gly Gly 
865                 870                 875                 880 


Arg Ala Ile Glu Arg Gly Pro Ala Gly Val Pro Cys Pro Ser Ala Gln 
                885                 890                 895     


Pro Asn His Cys Leu Ala Pro Gly Asn Ser Asp Gly Pro Asn Thr Ala 
            900                 905                 910         


Arg Lys Leu Lys Glu Asn Ala Gly Gln Asp Ile Lys Leu Pro Arg Lys 
        915                 920                 925             


Phe Asp Leu Pro Leu Thr Val Met Pro Ser Val Glu His Glu Lys Pro 
    930                 935                 940                 


Ala Arg Pro Glu Gly Gln Lys Ala Met Asn Trp Lys Glu Ser Phe Gln 
945                 950                 955                 960 


Met Gly Ser Lys Ser Ser Pro Pro Ser Pro Tyr Met Gly Phe Ser Gly 
                965                 970                 975     


Asn Ser Lys Asp Ser Arg Arg Gly Thr Ser Glu Leu Asp Arg Pro Leu 
            980                 985                 990         


Gln Gly Thr Leu Thr Leu Leu Arg  Ser Val Phe Arg Lys  Lys Glu Asn 
        995                 1000                 1005             


Arg Arg  Asn Glu Arg Ala Glu  Val Ser Pro Gln Val  Pro Pro Val 
    1010                 1015                 1020             


Ser Leu  Val Ser Gly Gly Leu  Ser Pro Ala Met Asp  Gly Gln Ala 
    1025                 1030                 1035             


Pro Gly  Ser Pro Pro Ala Leu  Arg Ile Pro Glu Gly  Leu Ala Arg 
    1040                 1045                 1050             


Gly Leu  Gly Ser Arg Leu Glu  Arg Asp Val Trp Ser  Ala Pro Ser 
    1055                 1060                 1065             


Ser Leu  Arg Leu Pro Arg Lys  Ala Ser Arg Ala Pro  Arg Gly Ser 
    1070                 1075                 1080             


Ala Leu  Gly Met Ser Gln Arg  Thr Val Pro Gly Glu  Gln Ala Ser 
    1085                 1090                 1095             


Tyr Gly  Thr Phe Gln Arg Val  Lys Tyr His Thr Leu  Ser Leu Gly 
    1100                 1105                 1110             


Arg Lys  Lys Thr Leu Pro Glu  Ser Ser Phe 
    1115                 1120             


<210> 14
<211> 605
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ala Arg 
1               5                   10                  15      


Tyr Thr Asp Ala His Tyr Ala Lys Ser Gly Tyr Gly Ala Tyr Thr Pro 
            20                  25                  30          


Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Leu Leu Glu Lys Glu Lys 
        35                  40                  45              


Leu Gly Phe Lys Pro Val Pro Thr Ser Ser Phe Leu Thr Arg Pro Arg 
    50                  55                  60                  


Thr Tyr Gly Pro Ser Ser Leu Leu Asp Tyr Asp Arg Gly Arg Pro Leu 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Thr Gly Gly Gly Lys Arg Ala Glu Ser Gln Thr 
                85                  90                  95      


Arg Gly Thr Glu Arg Pro Leu Gly Ser Gly Leu Ser Gly Gly Ser Gly 
            100                 105                 110         


Phe Pro Tyr Gly Val Thr Asn Asn Cys Leu Ser Tyr Leu Pro Ile Asn 
        115                 120                 125             


Ala Tyr Asp Gln Gly Val Thr Leu Thr Gln Lys Leu Asp Ser Gln Ser 
    130                 135                 140                 


Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr Arg 
145                 150                 155                 160 


Ile Asp Pro Arg Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg 
                165                 170                 175     


Lys Glu Leu Cys Thr Leu Gln Gly Leu Tyr Gln Thr Ala Ser Cys Pro 
            180                 185                 190         


Glu Tyr Leu Val Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala 
        195                 200                 205             


Ser Gln Val Pro Ser Gln Ala Pro Pro Ser Arg Val Pro Glu Ile Ile 
    210                 215                 220                 


Ser Pro Thr Tyr Arg Pro Ile Gly Arg Tyr Thr Leu Trp Glu Thr Gly 
225                 230                 235                 240 


Lys Gly Gln Ala Pro Gly Pro Ser Arg Ser Ser Ser Pro Gly Arg Asp 
                245                 250                 255     


Gly Met Asn Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu 
            260                 265                 270         


Gly Asn Thr Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr 
        275                 280                 285             


Arg Glu Leu Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu 
    290                 295                 300                 


His His Gly Ser Asn Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys 
305                 310                 315                 320 


Leu Ile Gln Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro 
                325                 330                 335     


Ser Glu Phe Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly 
            340                 345                 350         


Tyr Asn Gln Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly 
        355                 360                 365             


Leu His Asn Glu Val Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro 
    370                 375                 380                 


Glu Asn Leu Asp His Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp 
385                 390                 395                 400 


Arg Lys Tyr Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val 
                405                 410                 415     


Gly Gln Leu Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser 
            420                 425                 430         


Thr Val Phe Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg 
        435                 440                 445             


Gly Tyr Pro Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys 
    450                 455                 460                 


Glu Asp Val Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg 
465                 470                 475                 480 


Gly Arg Lys Arg Cys Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys 
                485                 490                 495     


Ile Leu Val Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr 
            500                 505                 510         


Ser Lys Leu Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu 
        515                 520                 525             


Arg Glu Phe Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr 
    530                 535                 540                 


Ala Val Ser Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala 
545                 550                 555                 560 


Tyr Cys Arg Ser Pro Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser 
                565                 570                 575     


Ser Val Thr Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr 
            580                 585                 590         


Leu Leu Phe Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
        595                 600                 605 


<210> 15
<211> 814
<212> PRT
<213> Homo sapiens

<400> 15
Met Arg Val Lys Asp Pro Thr Lys Ala Leu Pro Glu Lys Ala Lys Arg 
1               5                   10                  15      


Ser Lys Arg Pro Thr Val Pro His Asp Glu Asp Ser Ser Asp Asp Ile 
            20                  25                  30          


Ala Val Gly Leu Thr Cys Gln His Val Ser His Ala Ile Ser Val Asn 
        35                  40                  45              


His Val Lys Arg Ala Ile Ala Glu Asn Leu Trp Ser Val Cys Ser Glu 
    50                  55                  60                  


Cys Leu Lys Glu Arg Arg Phe Tyr Asp Gly Gln Leu Val Leu Thr Ser 
65                  70                  75                  80  


Asp Ile Trp Leu Cys Leu Lys Cys Gly Phe Gln Gly Cys Gly Lys Asn 
                85                  90                  95      


Ser Glu Ser Gln His Ser Leu Lys His Phe Lys Ser Ser Arg Thr Glu 
            100                 105                 110         


Pro His Cys Ile Ile Ile Asn Leu Ser Thr Trp Ile Ile Trp Cys Tyr 
        115                 120                 125             


Glu Cys Asp Glu Lys Leu Ser Thr His Cys Asn Lys Lys Val Leu Ala 
    130                 135                 140                 


Gln Ile Val Asp Phe Leu Gln Lys His Ala Ser Lys Thr Gln Thr Ser 
145                 150                 155                 160 


Ala Phe Ser Arg Ile Met Lys Leu Cys Glu Glu Lys Cys Glu Thr Asp 
                165                 170                 175     


Glu Ile Gln Lys Gly Gly Lys Cys Arg Asn Leu Ser Val Arg Gly Ile 
            180                 185                 190         


Thr Asn Leu Gly Asn Thr Cys Phe Phe Asn Ala Val Met Gln Asn Leu 
        195                 200                 205             


Ala Gln Thr Tyr Thr Leu Thr Asp Leu Met Asn Glu Ile Lys Glu Ser 
    210                 215                 220                 


Ser Thr Lys Leu Lys Ile Phe Pro Ser Ser Asp Ser Gln Leu Asp Pro 
225                 230                 235                 240 


Leu Val Val Glu Leu Ser Arg Pro Gly Pro Leu Thr Ser Ala Leu Phe 
                245                 250                 255     


Leu Phe Leu His Ser Met Lys Glu Thr Glu Lys Gly Pro Leu Ser Pro 
            260                 265                 270         


Lys Val Leu Phe Asn Gln Leu Cys Gln Lys Ala Pro Arg Phe Lys Asp 
        275                 280                 285             


Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu His Tyr Leu Leu Asp Ala 
    290                 295                 300                 


Val Arg Thr Glu Glu Thr Lys Arg Ile Gln Ala Ser Ile Leu Lys Ala 
305                 310                 315                 320 


Phe Asn Asn Pro Thr Thr Lys Thr Ala Asp Asp Glu Thr Arg Lys Lys 
                325                 330                 335     


Val Lys Ala Tyr Gly Lys Glu Gly Val Lys Met Asn Phe Ile Asp Arg 
            340                 345                 350         


Ile Phe Ile Gly Glu Leu Thr Ser Thr Val Met Cys Glu Glu Cys Ala 
        355                 360                 365             


Asn Ile Ser Thr Val Lys Asp Pro Phe Ile Asp Ile Ser Leu Pro Ile 
    370                 375                 380                 


Ile Glu Glu Arg Val Ser Lys Pro Leu Leu Trp Gly Arg Met Asn Lys 
385                 390                 395                 400 


Tyr Arg Ser Leu Arg Glu Thr Asp His Asp Arg Tyr Ser Gly Asn Val 
                405                 410                 415     


Thr Ile Glu Asn Ile His Gln Pro Arg Ala Ala Lys Lys His Ser Ser 
            420                 425                 430         


Ser Lys Asp Lys Ser Gln Leu Ile His Asp Arg Lys Cys Ile Arg Lys 
        435                 440                 445             


Leu Ser Ser Gly Glu Thr Val Thr Tyr Gln Lys Asn Glu Asn Leu Glu 
    450                 455                 460                 


Met Asn Gly Asp Ser Leu Met Phe Ala Ser Leu Met Asn Ser Glu Ser 
465                 470                 475                 480 


Arg Leu Asn Glu Ser Pro Thr Asp Asp Ser Glu Lys Glu Ala Ser His 
                485                 490                 495     


Ser Glu Ser Asn Val Asp Ala Asp Ser Glu Pro Ser Glu Ser Glu Ser 
            500                 505                 510         


Ala Ser Lys Gln Thr Gly Leu Phe Arg Ser Ser Ser Gly Ser Gly Val 
        515                 520                 525             


Gln Pro Asp Gly Pro Leu Tyr Pro Leu Ser Ala Gly Lys Leu Leu Tyr 
    530                 535                 540                 


Thr Lys Glu Thr Asp Ser Gly Asp Lys Glu Met Ala Glu Ala Ile Ser 
545                 550                 555                 560 


Glu Leu Arg Leu Ser Ser Thr Val Thr Gly Asp Gln Asp Phe Asp Arg 
                565                 570                 575     


Glu Asn Gln Pro Leu Asn Ile Ser Asn Asn Leu Cys Phe Leu Glu Gly 
            580                 585                 590         


Lys His Leu Arg Ser Tyr Ser Pro Gln Asn Ala Phe Gln Thr Leu Ser 
        595                 600                 605             


Gln Ser Tyr Ile Thr Thr Ser Lys Glu Cys Ser Ile Gln Ser Cys Leu 
    610                 615                 620                 


Tyr Gln Phe Thr Ser Met Glu Leu Leu Met Gly Asn Asn Lys Leu Leu 
625                 630                 635                 640 


Cys Glu Asn Cys Thr Lys Asn Lys Gln Lys Tyr Gln Glu Glu Thr Ser 
                645                 650                 655     


Phe Ala Glu Lys Lys Val Glu Gly Val Tyr Thr Asn Ala Arg Lys Gln 
            660                 665                 670         


Leu Leu Ile Ser Ala Val Pro Ala Val Leu Ile Leu His Leu Lys Arg 
        675                 680                 685             


Phe His Gln Ala Gly Leu Ser Leu Arg Lys Val Asn Arg His Val Asp 
    690                 695                 700                 


Phe Pro Leu Met Leu Asp Leu Ala Pro Phe Cys Ser Ala Thr Cys Lys 
705                 710                 715                 720 


Asn Ala Ser Val Gly Asp Lys Val Leu Tyr Gly Leu Tyr Gly Ile Val 
                725                 730                 735     


Glu His Ser Gly Ser Met Arg Glu Gly His Tyr Thr Ala Tyr Val Lys 
            740                 745                 750         


Val Arg Thr Pro Ser Arg Lys Leu Ser Glu His Asn Thr Lys Lys Lys 
        755                 760                 765             


Asn Val Pro Gly Leu Lys Ala Ala Asp Asn Glu Ser Ala Gly Gln Trp 
    770                 775                 780                 


Val His Val Ser Asp Thr Tyr Leu Gln Val Val Pro Glu Ser Arg Ala 
785                 790                 795                 800 


Leu Ser Ala Gln Ala Tyr Leu Leu Phe Tyr Glu Arg Val Leu 
                805                 810                 


<210> 16
<211> 1604
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Ala Lys Glu Ser Arg Ile Gly Phe Leu Ser Tyr Glu Glu Ala 
1               5                   10                  15      


Leu Arg Arg Val Thr Asp Val Glu Leu Lys Arg Leu Lys Asp Ala Phe 
            20                  25                  30          


Lys Arg Thr Cys Gly Leu Ser Tyr Tyr Met Gly Gln His Cys Phe Ile 
        35                  40                  45              


Arg Glu Val Leu Gly Asp Gly Val Pro Pro Lys Val Ala Glu Val Ile 
    50                  55                  60                  


Tyr Cys Ser Phe Gly Gly Thr Ser Lys Gly Leu His Phe Asn Asn Leu 
65                  70                  75                  80  


Ile Val Gly Leu Val Leu Leu Thr Arg Gly Lys Asp Glu Glu Lys Ala 
                85                  90                  95      


Lys Tyr Ile Phe Ser Leu Phe Ser Ser Glu Ser Gly Asn Tyr Val Ile 
            100                 105                 110         


Arg Glu Glu Met Glu Arg Met Leu His Val Val Asp Gly Lys Val Pro 
        115                 120                 125             


Asp Thr Leu Arg Lys Cys Phe Ser Glu Gly Glu Lys Val Asn Tyr Glu 
    130                 135                 140                 


Lys Phe Arg Asn Trp Leu Phe Leu Asn Lys Asp Ala Phe Thr Phe Ser 
145                 150                 155                 160 


Arg Trp Leu Leu Ser Gly Gly Val Tyr Val Thr Leu Thr Asp Asp Ser 
                165                 170                 175     


Asp Thr Pro Thr Phe Tyr Gln Thr Leu Ala Gly Val Thr His Leu Glu 
            180                 185                 190         


Glu Ser Asp Ile Ile Asp Leu Glu Lys Arg Tyr Trp Leu Leu Lys Ala 
        195                 200                 205             


Gln Ser Arg Thr Gly Arg Phe Asp Leu Glu Thr Phe Gly Pro Leu Val 
    210                 215                 220                 


Ser Pro Pro Ile Arg Pro Ser Leu Ser Glu Gly Leu Phe Asn Ala Phe 
225                 230                 235                 240 


Asp Glu Asn Arg Asp Asn His Ile Asp Phe Lys Glu Ile Ser Cys Gly 
                245                 250                 255     


Leu Ser Ala Cys Cys Arg Gly Pro Leu Ala Glu Arg Gln Lys Phe Cys 
            260                 265                 270         


Phe Lys Val Phe Asp Val Asp Arg Asp Gly Val Leu Ser Arg Val Glu 
        275                 280                 285             


Leu Arg Asp Met Val Val Ala Leu Leu Glu Val Trp Lys Asp Asn Arg 
    290                 295                 300                 


Thr Asp Asp Ile Pro Glu Leu His Met Asp Leu Ser Asp Ile Val Glu 
305                 310                 315                 320 


Gly Ile Leu Asn Ala His Asp Thr Thr Lys Met Gly His Leu Thr Leu 
                325                 330                 335     


Glu Asp Tyr Gln Ile Trp Ser Val Lys Asn Val Leu Ala Asn Glu Phe 
            340                 345                 350         


Leu Asn Leu Leu Phe Gln Val Cys His Ile Val Leu Gly Leu Arg Pro 
        355                 360                 365             


Ala Thr Pro Glu Glu Glu Gly Gln Ile Ile Arg Gly Trp Leu Glu Arg 
    370                 375                 380                 


Glu Ser Arg Tyr Gly Leu Gln Ala Gly His Asn Trp Phe Ile Ile Ser 
385                 390                 395                 400 


Met Gln Trp Trp Gln Gln Trp Lys Glu Tyr Val Lys Tyr Asp Ala Asn 
                405                 410                 415     


Pro Val Val Ile Glu Pro Ser Ser Val Leu Asn Gly Gly Lys Tyr Ser 
            420                 425                 430         


Phe Gly Thr Ala Ala His Pro Met Glu Gln Val Glu Asp Arg Ile Gly 
        435                 440                 445             


Ser Ser Leu Ser Tyr Val Asn Thr Thr Glu Glu Lys Phe Ser Asp Asn 
    450                 455                 460                 


Ile Ser Thr Ala Ser Glu Ala Ser Glu Thr Ala Gly Ser Gly Phe Leu 
465                 470                 475                 480 


Tyr Ser Ala Thr Pro Gly Ala Asp Val Cys Phe Ala Arg Gln His Asn 
                485                 490                 495     


Thr Ser Asp Asn Asn Asn Gln Cys Leu Leu Gly Ala Asn Gly Asn Ile 
            500                 505                 510         


Leu Leu His Leu Asn Pro Gln Lys Pro Gly Ala Ile Asp Asn Gln Pro 
        515                 520                 525             


Leu Val Thr Gln Glu Pro Val Lys Ala Thr Ser Leu Thr Leu Glu Gly 
    530                 535                 540                 


Gly Arg Leu Lys Arg Thr Pro Gln Leu Ile His Gly Arg Asp Tyr Glu 
545                 550                 555                 560 


Met Val Pro Glu Pro Val Trp Arg Ala Leu Tyr His Trp Tyr Gly Ala 
                565                 570                 575     


Asn Leu Ala Leu Pro Arg Pro Val Ile Lys Asn Ser Lys Thr Asp Ile 
            580                 585                 590         


Pro Glu Leu Glu Leu Phe Pro Arg Tyr Leu Leu Phe Leu Arg Gln Gln 
        595                 600                 605             


Pro Ala Thr Arg Thr Gln Gln Ser Asn Ile Trp Val Asn Met Gly Asn 
    610                 615                 620                 


Val Pro Ser Pro Asn Ala Pro Leu Lys Arg Val Leu Ala Tyr Thr Gly 
625                 630                 635                 640 


Cys Phe Ser Arg Met Gln Thr Ile Lys Glu Ile His Glu Tyr Leu Ser 
                645                 650                 655     


Gln Arg Leu Arg Ile Lys Glu Glu Asp Met Arg Leu Trp Leu Tyr Asn 
            660                 665                 670         


Ser Glu Asn Tyr Leu Thr Leu Leu Asp Asp Glu Asp His Lys Leu Glu 
        675                 680                 685             


Tyr Leu Lys Ile Gln Asp Glu Gln His Leu Val Ile Glu Val Arg Asn 
    690                 695                 700                 


Lys Asp Met Ser Trp Pro Glu Glu Met Ser Phe Ile Ala Asn Ser Ser 
705                 710                 715                 720 


Lys Ile Asp Arg His Lys Val Pro Thr Glu Lys Gly Ala Thr Gly Leu 
                725                 730                 735     


Ser Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ser Ile Gln Cys Val 
            740                 745                 750         


Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe Ile Ser Gly Arg His Leu 
        755                 760                 765             


Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly Met Lys Gly His Met Ala 
    770                 775                 780                 


Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu Trp Ser Gly Thr Gln Lys 
785                 790                 795                 800 


Asn Val Ala Pro Leu Lys Leu Arg Trp Thr Ile Ala Lys Tyr Ala Pro 
                805                 810                 815     


Arg Phe Asn Gly Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe 
            820                 825                 830         


Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val His Glu Lys Pro 
        835                 840                 845             


Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg Pro Asp Trp Glu Val Ala 
    850                 855                 860                 


Ala Glu Ala Trp Asp Asn His Leu Arg Arg Asn Arg Ser Ile Val Val 
865                 870                 875                 880 


Asp Leu Phe His Gly Gln Leu Arg Ser Gln Val Lys Cys Lys Thr Cys 
                885                 890                 895     


Gly His Ile Ser Val Arg Phe Asp Pro Phe Asn Phe Leu Ser Leu Pro 
            900                 905                 910         


Leu Pro Met Asp Ser Tyr Met His Leu Glu Ile Thr Val Ile Lys Leu 
        915                 920                 925             


Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu Arg Leu Asn Met Asp Glu 
    930                 935                 940                 


Lys Tyr Thr Gly Leu Lys Lys Gln Leu Ser Asp Leu Cys Gly Leu Asn 
945                 950                 955                 960 


Ser Glu Gln Ile Leu Leu Ala Glu Val His Gly Ser Asn Ile Lys Asn 
                965                 970                 975     


Phe Pro Gln Asp Asn Gln Lys Val Arg Leu Ser Val Ser Gly Phe Leu 
            980                 985                 990         


Cys Ala Phe Glu Ile Pro Val Pro  Val Ser Pro Ile Ser  Ala Ser Ser 
        995                 1000                 1005             


Pro Thr  Gln Thr Asp Phe Ser  Ser Ser Pro Ser Thr  Asn Glu Met 
    1010                 1015                 1020             


Phe Thr  Leu Thr Thr Asn Gly  Asp Leu Pro Arg Pro  Ile Phe Ile 
    1025                 1030                 1035             


Pro Asn  Gly Met Pro Asn Thr  Val Val Pro Cys Gly  Thr Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Asn Gly Met Val  Asn Gly His Met Pro  Ser Leu Pro 
    1055                 1060                 1065             


Asp Ser  Pro Phe Thr Gly Tyr  Ile Ile Ala Val His  Arg Lys Met 
    1070                 1075                 1080             


Met Arg  Thr Glu Leu Tyr Phe  Leu Ser Ser Gln Lys  Asn Arg Pro 
    1085                 1090                 1095             


Ser Leu  Phe Gly Met Pro Leu  Ile Val Pro Cys Thr  Val His Thr 
    1100                 1105                 1110             


Arg Lys  Lys Asp Leu Tyr Asp  Ala Val Trp Ile Gln  Val Ser Arg 
    1115                 1120                 1125             


Leu Ala  Ser Pro Leu Pro Pro  Gln Glu Ala Ser Asn  His Ala Gln 
    1130                 1135                 1140             


Asp Cys  Asp Asp Ser Met Gly  Tyr Gln Tyr Pro Phe  Thr Leu Arg 
    1145                 1150                 1155             


Val Val  Gln Lys Asp Gly Asn  Ser Cys Ala Trp Cys  Pro Trp Tyr 
    1160                 1165                 1170             


Arg Phe  Cys Arg Gly Cys Lys  Ile Asp Cys Gly Glu  Asp Arg Ala 
    1175                 1180                 1185             


Phe Ile  Gly Asn Ala Tyr Ile  Ala Val Asp Trp Asp  Pro Thr Ala 
    1190                 1195                 1200             


Leu His  Leu Arg Tyr Gln Thr  Ser Gln Glu Arg Val  Val Asp Glu 
    1205                 1210                 1215             


His Glu  Ser Val Glu Gln Ser  Arg Arg Ala Gln Ala  Glu Pro Ile 
    1220                 1225                 1230             


Asn Leu  Asp Ser Cys Leu Arg  Ala Phe Thr Ser Glu  Glu Glu Leu 
    1235                 1240                 1245             


Gly Glu  Asn Glu Met Tyr Tyr  Cys Ser Lys Cys Lys  Thr His Cys 
    1250                 1255                 1260             


Leu Ala  Thr Lys Lys Leu Asp  Leu Trp Arg Leu Pro  Pro Ile Leu 
    1265                 1270                 1275             


Ile Ile  His Leu Lys Arg Phe  Gln Phe Val Asn Gly  Arg Trp Ile 
    1280                 1285                 1290             


Lys Ser  Gln Lys Ile Val Lys  Phe Pro Arg Glu Ser  Phe Asp Pro 
    1295                 1300                 1305             


Ser Ala  Phe Leu Val Pro Arg  Asp Pro Ala Leu Cys  Gln His Lys 
    1310                 1315                 1320             


Pro Leu  Thr Pro Gln Gly Asp  Glu Leu Ser Glu Pro  Arg Ile Leu 
    1325                 1330                 1335             


Ala Arg  Glu Val Lys Lys Val  Asp Ala Gln Ser Ser  Ala Gly Glu 
    1340                 1345                 1350             


Glu Asp  Val Leu Leu Ser Lys  Ser Pro Ser Ser Leu  Ser Ala Asn 
    1355                 1360                 1365             


Ile Ile  Ser Ser Pro Lys Gly  Ser Pro Ser Ser Ser  Arg Lys Ser 
    1370                 1375                 1380             


Gly Thr  Ser Cys Pro Ser Ser  Lys Asn Ser Ser Pro  Asn Ser Ser 
    1385                 1390                 1395             


Pro Arg  Thr Leu Gly Arg Ser  Lys Gly Arg Leu Arg  Leu Pro Gln 
    1400                 1405                 1410             


Ile Gly  Ser Lys Asn Lys Leu  Ser Ser Ser Lys Glu  Asn Leu Asp 
    1415                 1420                 1425             


Ala Ser  Lys Glu Asn Gly Ala  Gly Gln Ile Cys Glu  Leu Ala Asp 
    1430                 1435                 1440             


Ala Leu  Ser Arg Gly His Val  Leu Gly Gly Ser Gln  Pro Glu Leu 
    1445                 1450                 1455             


Val Thr  Pro Gln Asp His Glu  Val Ala Leu Ala Asn  Gly Phe Leu 
    1460                 1465                 1470             


Tyr Glu  His Glu Ala Cys Gly  Asn Gly Tyr Ser Asn  Gly Gln Leu 
    1475                 1480                 1485             


Gly Asn  His Ser Glu Glu Asp  Ser Thr Asp Asp Gln  Arg Glu Asp 
    1490                 1495                 1500             


Thr Arg  Ile Lys Pro Ile Tyr  Asn Leu Tyr Ala Ile  Ser Cys His 
    1505                 1510                 1515             


Ser Gly  Ile Leu Gly Gly Gly  His Tyr Val Thr Tyr  Ala Lys Asn 
    1520                 1525                 1530             


Pro Asn  Cys Lys Trp Tyr Cys  Tyr Asn Asp Ser Ser  Cys Lys Glu 
    1535                 1540                 1545             


Leu His  Pro Asp Glu Ile Asp  Thr Asp Ser Ala Tyr  Ile Leu Phe 
    1550                 1555                 1560             


Tyr Glu  Gln Gln Gly Ile Asp  Tyr Ala Gln Phe Leu  Pro Lys Thr 
    1565                 1570                 1575             


Asp Gly  Lys Lys Met Ala Asp  Thr Ser Ser Met Asp  Glu Asp Phe 
    1580                 1585                 1590             


Glu Ser  Asp Tyr Lys Lys Tyr  Cys Val Leu Gln 
    1595                 1600                 


<210> 17
<211> 398
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ser Glu Asp 
385                 390                 395             


<210> 18
<211> 1324
<212> PRT
<213> Homo sapiens

<400> 18
Met Thr Ile Val Asp Lys Ala Ser Glu Ser Ser Asp Pro Ser Ala Tyr 
1               5                   10                  15      


Gln Asn Gln Pro Gly Ser Ser Glu Ala Val Ser Pro Gly Asp Met Asp 
            20                  25                  30          


Ala Gly Ser Ala Ser Trp Gly Ala Val Ser Ser Leu Asn Asp Val Ser 
        35                  40                  45              


Asn His Thr Leu Ser Leu Gly Pro Val Pro Gly Ala Val Val Tyr Ser 
    50                  55                  60                  


Ser Ser Ser Val Pro Asp Lys Ser Lys Pro Ser Pro Gln Lys Asp Gln 
65                  70                  75                  80  


Ala Leu Gly Asp Gly Ile Ala Pro Pro Gln Lys Val Leu Phe Pro Ser 
                85                  90                  95      


Glu Lys Ile Cys Leu Lys Trp Gln Gln Thr His Arg Val Gly Ala Gly 
            100                 105                 110         


Leu Gln Asn Leu Gly Asn Thr Cys Phe Ala Asn Ala Ala Leu Gln Cys 
        115                 120                 125             


Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser His Glu His 
    130                 135                 140                 


Ser Lys Thr Cys His Ala Glu Gly Phe Cys Met Met Cys Thr Met Gln 
145                 150                 155                 160 


Ala His Ile Thr Gln Ala Leu Ser Asn Pro Gly Asp Val Ile Lys Pro 
                165                 170                 175     


Met Phe Val Ile Asn Glu Met Arg Arg Ile Ala Arg His Phe Arg Phe 
            180                 185                 190         


Gly Asn Gln Glu Asp Ala His Glu Phe Leu Gln Tyr Thr Val Asp Ala 
        195                 200                 205             


Met Gln Lys Ala Cys Leu Asn Gly Ser Asn Lys Leu Asp Arg His Thr 
    210                 215                 220                 


Gln Ala Thr Thr Leu Val Cys Gln Ile Phe Gly Gly Tyr Leu Arg Ser 
225                 230                 235                 240 


Arg Val Lys Cys Leu Asn Cys Lys Gly Val Ser Asp Thr Phe Asp Pro 
                245                 250                 255     


Tyr Leu Asp Ile Thr Leu Glu Ile Lys Ala Ala Gln Ser Val Asn Lys 
            260                 265                 270         


Ala Leu Glu Gln Phe Val Lys Pro Glu Gln Leu Asp Gly Glu Asn Ser 
        275                 280                 285             


Tyr Lys Cys Ser Lys Cys Lys Lys Met Val Pro Ala Ser Lys Arg Phe 
    290                 295                 300                 


Thr Ile His Arg Ser Ser Asn Val Leu Thr Leu Ser Leu Lys Arg Phe 
305                 310                 315                 320 


Ala Asn Phe Thr Gly Gly Lys Ile Ala Lys Asp Val Lys Tyr Pro Glu 
                325                 330                 335     


Tyr Leu Asp Ile Arg Pro Tyr Met Ser Gln Pro Asn Gly Glu Pro Ile 
            340                 345                 350         


Val Tyr Val Leu Tyr Ala Val Leu Val His Thr Gly Phe Asn Cys His 
        355                 360                 365             


Ala Gly His Tyr Phe Cys Tyr Ile Lys Ala Ser Asn Gly Leu Trp Tyr 
    370                 375                 380                 


Gln Met Asn Asp Ser Ile Val Ser Thr Ser Asp Ile Arg Ser Val Leu 
385                 390                 395                 400 


Ser Gln Gln Ala Tyr Val Leu Phe Tyr Ile Arg Ser His Asp Val Lys 
                405                 410                 415     


Asn Gly Gly Glu Leu Thr His Pro Thr His Ser Pro Gly Gln Ser Ser 
            420                 425                 430         


Pro Arg Pro Val Ile Ser Gln Arg Val Val Thr Asn Lys Gln Ala Ala 
        435                 440                 445             


Pro Gly Phe Ile Gly Pro Gln Leu Pro Ser His Met Ile Lys Asn Pro 
    450                 455                 460                 


Pro His Leu Asn Gly Thr Gly Pro Leu Lys Asp Thr Pro Ser Ser Ser 
465                 470                 475                 480 


Met Ser Ser Pro Asn Gly Asn Ser Ser Val Asn Arg Ala Ser Pro Val 
                485                 490                 495     


Asn Ala Ser Ala Ser Val Gln Asn Trp Ser Val Asn Arg Ser Ser Val 
            500                 505                 510         


Ile Pro Glu His Pro Lys Lys Gln Lys Ile Thr Ile Ser Ile His Asn 
        515                 520                 525             


Lys Leu Pro Val Arg Gln Cys Gln Ser Gln Pro Asn Leu His Ser Asn 
    530                 535                 540                 


Ser Leu Glu Asn Pro Thr Lys Pro Val Pro Ser Ser Thr Ile Thr Asn 
545                 550                 555                 560 


Ser Ala Val Gln Ser Thr Ser Asn Ala Ser Thr Met Ser Val Ser Ser 
                565                 570                 575     


Lys Val Thr Lys Pro Ile Pro Arg Ser Glu Ser Cys Ser Gln Pro Val 
            580                 585                 590         


Met Asn Gly Lys Ser Lys Leu Asn Ser Ser Val Leu Val Pro Tyr Gly 
        595                 600                 605             


Ala Glu Ser Ser Glu Asp Ser Asp Glu Glu Ser Lys Gly Leu Gly Lys 
    610                 615                 620                 


Glu Asn Gly Ile Gly Thr Ile Val Ser Ser His Ser Pro Gly Gln Asp 
625                 630                 635                 640 


Ala Glu Asp Glu Glu Ala Thr Pro His Glu Leu Gln Glu Pro Met Thr 
                645                 650                 655     


Leu Asn Gly Ala Asn Ser Ala Asp Ser Asp Ser Asp Pro Lys Glu Asn 
            660                 665                 670         


Gly Leu Ala Pro Asp Gly Ala Ser Cys Gln Gly Gln Pro Ala Leu His 
        675                 680                 685             


Ser Glu Asn Pro Phe Ala Lys Ala Asn Gly Leu Pro Gly Lys Leu Met 
    690                 695                 700                 


Pro Ala Pro Leu Leu Ser Leu Pro Glu Asp Lys Ile Leu Glu Thr Phe 
705                 710                 715                 720 


Arg Leu Ser Asn Lys Leu Lys Gly Ser Thr Asp Glu Met Ser Ala Pro 
                725                 730                 735     


Gly Ala Glu Arg Gly Pro Pro Glu Asp Arg Asp Ala Glu Pro Gln Pro 
            740                 745                 750         


Gly Ser Pro Ala Ala Glu Ser Leu Glu Glu Pro Asp Ala Ala Ala Gly 
        755                 760                 765             


Leu Ser Ser Thr Lys Lys Ala Pro Pro Pro Arg Asp Pro Gly Thr Pro 
    770                 775                 780                 


Ala Thr Lys Glu Gly Ala Trp Glu Ala Met Ala Val Ala Pro Glu Glu 
785                 790                 795                 800 


Pro Pro Pro Ser Ala Gly Glu Asp Ile Val Gly Asp Thr Ala Pro Pro 
                805                 810                 815     


Asp Leu Cys Asp Pro Gly Ser Leu Thr Gly Asp Ala Ser Pro Leu Ser 
            820                 825                 830         


Gln Asp Ala Lys Gly Met Ile Ala Glu Gly Pro Arg Asp Ser Ala Leu 
        835                 840                 845             


Ala Glu Ala Pro Glu Gly Leu Ser Pro Ala Pro Pro Ala Arg Ser Glu 
    850                 855                 860                 


Glu Pro Cys Glu Gln Pro Leu Leu Val His Pro Ser Gly Asp His Ala 
865                 870                 875                 880 


Arg Asp Ala Gln Asp Pro Ser Gln Ser Leu Gly Ala Pro Glu Ala Ala 
                885                 890                 895     


Glu Arg Pro Pro Ala Pro Val Leu Asp Met Ala Pro Ala Gly His Pro 
            900                 905                 910         


Glu Gly Asp Ala Glu Pro Ser Pro Gly Glu Arg Val Glu Asp Ala Ala 
        915                 920                 925             


Ala Pro Lys Ala Pro Gly Pro Ser Pro Ala Lys Glu Lys Ile Gly Ser 
    930                 935                 940                 


Leu Arg Lys Val Asp Arg Gly His Tyr Arg Ser Arg Arg Glu Arg Ser 
945                 950                 955                 960 


Ser Ser Gly Glu Pro Ala Arg Glu Ser Arg Ser Lys Thr Glu Gly His 
                965                 970                 975     


Arg His Arg Arg Arg Arg Thr Cys Pro Arg Glu Arg Asp Arg Gln Asp 
            980                 985                 990         


Arg His Ala Pro Glu His His Pro  Gly His Gly Asp Arg  Leu Ser Pro 
        995                 1000                 1005             


Gly Glu  Arg Arg Ser Leu Gly  Arg Cys Ser His His  His Ser Arg 
    1010                 1015                 1020             


His Arg  Ser Gly Val Glu Leu  Asp Trp Val Arg His  His Tyr Thr 
    1025                 1030                 1035             


Glu Gly  Glu Arg Gly Trp Gly  Arg Glu Lys Phe Tyr  Pro Asp Arg 
    1040                 1045                 1050             


Pro Arg  Trp Asp Arg Cys Arg  Tyr Tyr His Asp Arg  Tyr Ala Leu 
    1055                 1060                 1065             


Tyr Ala  Ala Arg Asp Trp Lys  Pro Phe His Gly Gly  Arg Glu His 
    1070                 1075                 1080             


Glu Arg  Ala Gly Leu His Glu  Arg Pro His Lys Asp  His Asn Arg 
    1085                 1090                 1095             


Gly Arg  Arg Gly Cys Glu Pro  Ala Arg Glu Arg Glu  Arg His Arg 
    1100                 1105                 1110             


Pro Ser  Ser Pro Arg Ala Gly  Ala Pro His Ala Leu  Ala Pro His 
    1115                 1120                 1125             


Pro Asp  Arg Phe Ser His Asp  Arg Thr Ala Leu Val  Ala Gly Asp 
    1130                 1135                 1140             


Asn Cys  Asn Leu Ser Asp Arg  Phe His Glu His Glu  Asn Gly Lys 
    1145                 1150                 1155             


Ser Arg  Lys Arg Arg His Asp  Ser Val Glu Asn Ser  Asp Ser His 
    1160                 1165                 1170             


Val Glu  Lys Lys Ala Arg Arg  Ser Glu Gln Lys Asp  Pro Leu Glu 
    1175                 1180                 1185             


Glu Pro  Lys Ala Lys Lys His  Lys Lys Ser Lys Lys  Lys Lys Lys 
    1190                 1195                 1200             


Ser Lys  Asp Lys His Arg Asp  Arg Asp Ser Arg His  Gln Gln Asp 
    1205                 1210                 1215             


Ser Asp  Leu Ser Ala Ala Cys  Ser Asp Ala Asp Leu  His Arg His 
    1220                 1225                 1230             


Lys Lys  Lys Lys Lys Lys Lys  Lys Arg His Ser Arg  Lys Ser Glu 
    1235                 1240                 1245             


Asp Phe  Val Lys Asp Ser Glu  Leu His Leu Pro Arg  Val Thr Ser 
    1250                 1255                 1260             


Leu Glu  Thr Val Ala Gln Phe  Arg Arg Ala Gln Gly  Gly Phe Pro 
    1265                 1270                 1275             


Leu Ser  Gly Gly Pro Pro Leu  Glu Gly Val Gly Pro  Phe Arg Glu 
    1280                 1285                 1290             


Lys Thr  Lys His Leu Arg Met  Glu Ser Arg Asp Asp  Arg Cys Arg 
    1295                 1300                 1305             


Leu Phe  Glu Tyr Gly Gln Gly  Lys Arg Arg Tyr Leu  Glu Leu Gly 
    1310                 1315                 1320             


Arg 
    


<210> 19
<211> 530
<212> PRT
<213> Homo sapiens

<400> 19
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Asp Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Leu Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Ser Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Phe Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Lys Ile Gly Asn Thr Phe Tyr Val Asn Val Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ser Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


Asp Ser Gln Thr Cys His Leu His Lys Cys Cys Met Phe Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Val Leu Ala Ala Gly Phe His Arg Gly Glu Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Leu Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Ala Tyr Trp Arg Ser Gln Ile Lys Tyr Leu 
        195                 200                 205             


His Cys His Gly Val Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Lys Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Lys Ala Pro Ala Ser Lys Thr Leu Thr Leu Pro Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Lys Cys Arg Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Gly Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Lys Pro Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Ser Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Asn Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 20
<211> 530
<212> PRT
<213> Homo sapiens

<400> 20
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 21
<211> 863
<212> PRT
<213> Homo sapiens

<400> 21
Met Gln Arg Arg Gly Ala Leu Phe Gly Met Pro Gly Gly Ser Gly Gly 
1               5                   10                  15      


Arg Lys Met Ala Ala Gly Asp Ile Gly Glu Leu Leu Val Pro His Met 
            20                  25                  30          


Pro Thr Ile Arg Val Pro Arg Ser Gly Asp Arg Val Tyr Lys Asn Glu 
        35                  40                  45              


Cys Ala Phe Ser Tyr Asp Ser Pro Asn Ser Glu Gly Gly Leu Tyr Val 
    50                  55                  60                  


Cys Met Asn Thr Phe Leu Ala Phe Gly Arg Glu His Val Glu Arg His 
65                  70                  75                  80  


Phe Arg Lys Thr Gly Gln Ser Val Tyr Met His Leu Lys Arg His Val 
                85                  90                  95      


Arg Glu Lys Val Arg Gly Ala Ser Gly Gly Ala Leu Pro Lys Arg Arg 
            100                 105                 110         


Asn Ser Lys Ile Phe Leu Asp Leu Asp Thr Asp Asp Asp Leu Asn Ser 
        115                 120                 125             


Asp Asp Tyr Glu Tyr Glu Asp Glu Ala Lys Leu Val Ile Phe Pro Asp 
    130                 135                 140                 


His Tyr Glu Ile Ala Leu Pro Asn Ile Glu Glu Leu Pro Ala Leu Val 
145                 150                 155                 160 


Thr Ile Ala Cys Asp Ala Val Leu Ser Ser Lys Ser Pro Tyr Arg Lys 
                165                 170                 175     


Gln Asp Pro Asp Thr Trp Glu Asn Glu Leu Pro Val Ser Lys Tyr Ala 
            180                 185                 190         


Asn Asn Leu Thr Gln Leu Asp Asn Gly Val Arg Ile Pro Pro Ser Gly 
        195                 200                 205             


Trp Lys Cys Ala Arg Cys Asp Leu Arg Glu Asn Leu Trp Leu Asn Leu 
    210                 215                 220                 


Thr Asp Gly Ser Val Leu Cys Gly Lys Trp Phe Phe Asp Ser Ser Gly 
225                 230                 235                 240 


Gly Asn Gly His Ala Leu Glu His Tyr Arg Asp Met Gly Tyr Pro Leu 
                245                 250                 255     


Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala Asp Val Tyr Ser 
            260                 265                 270         


Phe Gln Glu Glu Glu Pro Val Leu Asp Pro His Leu Ala Lys His Leu 
        275                 280                 285             


Ala His Phe Gly Ile Asp Met Leu His Met His Gly Thr Glu Asn Gly 
    290                 295                 300                 


Leu Gln Asp Asn Asp Ile Lys Leu Arg Val Ser Glu Trp Glu Val Ile 
305                 310                 315                 320 


Gln Glu Ser Gly Thr Lys Leu Lys Pro Met Tyr Gly Pro Gly Tyr Thr 
                325                 330                 335     


Gly Leu Lys Asn Leu Gly Asn Ser Cys Tyr Leu Ser Ser Val Met Gln 
            340                 345                 350         


Ala Ile Phe Ser Ile Pro Glu Phe Gln Arg Ala Tyr Val Gly Asn Leu 
        355                 360                 365             


Pro Arg Ile Phe Asp Tyr Ser Pro Leu Asp Pro Thr Gln Asp Phe Asn 
    370                 375                 380                 


Thr Gln Met Thr Lys Leu Gly His Gly Leu Leu Ser Gly Gln Tyr Ser 
385                 390                 395                 400 


Lys Pro Pro Val Lys Ser Glu Leu Ile Glu Gln Val Met Lys Glu Glu 
                405                 410                 415     


His Lys Pro Gln Gln Asn Gly Ile Ser Pro Arg Met Phe Lys Ala Phe 
            420                 425                 430         


Val Ser Lys Ser His Pro Glu Phe Ser Ser Asn Arg Gln Gln Asp Ala 
        435                 440                 445             


Gln Glu Phe Phe Leu His Leu Val Asn Leu Val Glu Arg Asn Arg Ile 
    450                 455                 460                 


Gly Ser Glu Asn Pro Ser Asp Val Phe Arg Phe Leu Val Glu Glu Arg 
465                 470                 475                 480 


Ile Gln Cys Cys Gln Thr Arg Lys Val Arg Tyr Thr Glu Arg Val Asp 
                485                 490                 495     


Tyr Leu Met Gln Leu Pro Val Ala Met Glu Ala Ala Thr Asn Lys Asp 
            500                 505                 510         


Glu Leu Ile Ala Tyr Glu Leu Thr Arg Arg Glu Ala Glu Ala Asn Arg 
        515                 520                 525             


Arg Pro Leu Pro Glu Leu Val Arg Ala Lys Ile Pro Phe Ser Ala Cys 
    530                 535                 540                 


Leu Gln Ala Phe Ser Glu Pro Glu Asn Val Asp Asp Phe Trp Ser Ser 
545                 550                 555                 560 


Ala Leu Gln Ala Lys Ser Ala Gly Val Lys Thr Ser Arg Phe Ala Ser 
                565                 570                 575     


Phe Pro Glu Tyr Leu Val Val Gln Ile Lys Lys Phe Thr Phe Gly Leu 
            580                 585                 590         


Asp Trp Val Pro Lys Lys Phe Asp Val Ser Ile Asp Met Pro Asp Leu 
        595                 600                 605             


Leu Asp Ile Asn His Leu Arg Ala Arg Gly Leu Gln Pro Gly Glu Glu 
    610                 615                 620                 


Glu Leu Pro Asp Ile Ser Pro Pro Ile Val Ile Pro Asp Asp Ser Lys 
625                 630                 635                 640 


Asp Arg Leu Met Asn Gln Leu Ile Asp Pro Ser Asp Ile Asp Glu Ser 
                645                 650                 655     


Ser Val Met Gln Leu Ala Glu Met Gly Phe Pro Leu Glu Ala Cys Arg 
            660                 665                 670         


Lys Ala Val Tyr Phe Thr Gly Asn Met Gly Ala Glu Val Ala Phe Asn 
        675                 680                 685             


Trp Ile Ile Val His Met Glu Glu Pro Asp Phe Ala Glu Pro Leu Thr 
    690                 695                 700                 


Met Pro Gly Tyr Gly Gly Ala Ala Ser Ala Gly Ala Ser Val Phe Gly 
705                 710                 715                 720 


Ala Ser Gly Leu Asp Asn Gln Pro Pro Glu Glu Ile Val Ala Ile Ile 
                725                 730                 735     


Thr Ser Met Gly Phe Gln Arg Asn Gln Ala Ile Gln Ala Leu Arg Ala 
            740                 745                 750         


Thr Asn Asn Asn Leu Glu Arg Ala Leu Asp Trp Ile Phe Ser His Pro 
        755                 760                 765             


Glu Phe Glu Glu Asp Ser Asp Phe Val Ile Glu Met Glu Asn Asn Ala 
    770                 775                 780                 


Asn Ala Asn Ile Ile Ser Glu Ala Lys Pro Glu Gly Pro Arg Val Lys 
785                 790                 795                 800 


Asp Gly Ser Gly Thr Tyr Glu Leu Phe Ala Phe Ile Ser His Met Gly 
                805                 810                 815     


Thr Ser Thr Met Ser Gly His Tyr Ile Cys His Ile Lys Lys Glu Gly 
            820                 825                 830         


Arg Trp Val Ile Tyr Asn Asp His Lys Val Cys Ala Ser Glu Arg Pro 
        835                 840                 845             


Pro Lys Asp Leu Gly Tyr Met Tyr Phe Tyr Arg Arg Ile Pro Ser 
    850                 855                 860             


<210> 22
<211> 963
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Val Ala Pro Arg Leu Phe Gly Gly Leu Cys Phe Arg Phe Arg 
1               5                   10                  15      


Asp Gln Asn Pro Glu Val Ala Val Glu Gly Arg Leu Pro Ile Ser His 
            20                  25                  30          


Ser Cys Val Gly Cys Arg Arg Glu Arg Thr Ala Met Ala Thr Val Ala 
        35                  40                  45              


Ala Asn Pro Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Val 
    50                  55                  60                  


Thr Glu Asp Arg Glu Pro Gln His Glu Glu Leu Pro Gly Leu Asp Ser 
65                  70                  75                  80  


Gln Trp Arg Gln Ile Glu Asn Gly Glu Ser Gly Arg Glu Arg Pro Leu 
                85                  90                  95      


Arg Ala Gly Glu Ser Trp Phe Leu Val Glu Lys His Trp Tyr Lys Gln 
            100                 105                 110         


Trp Glu Ala Tyr Val Gln Gly Gly Asp Gln Asp Ser Ser Thr Phe Pro 
        115                 120                 125             


Gly Cys Ile Asn Asn Ala Thr Leu Phe Gln Asp Glu Ile Asn Trp Arg 
    130                 135                 140                 


Leu Lys Glu Gly Leu Val Glu Gly Glu Asp Tyr Val Leu Leu Pro Ala 
145                 150                 155                 160 


Ala Ala Trp His Tyr Leu Val Ser Trp Tyr Gly Leu Glu His Gly Gln 
                165                 170                 175     


Pro Pro Ile Glu Arg Lys Val Ile Glu Leu Pro Asn Ile Gln Lys Val 
            180                 185                 190         


Glu Val Tyr Pro Val Glu Leu Leu Leu Val Arg His Asn Asp Leu Gly 
        195                 200                 205             


Lys Ser His Thr Val Gln Phe Ser His Thr Asp Ser Ile Gly Leu Val 
    210                 215                 220                 


Leu Arg Thr Ala Arg Glu Arg Phe Leu Val Glu Pro Gln Glu Asp Thr 
225                 230                 235                 240 


Arg Leu Trp Ala Lys Asn Ser Glu Gly Ser Leu Asp Arg Leu Tyr Asp 
                245                 250                 255     


Thr His Ile Thr Val Leu Asp Ala Ala Leu Glu Thr Gly Gln Leu Ile 
            260                 265                 270         


Ile Met Glu Thr Arg Lys Lys Asp Gly Thr Trp Pro Ser Ala Gln Leu 
        275                 280                 285             


His Val Met Asn Asn Asn Met Ser Glu Glu Asp Glu Asp Phe Lys Gly 
    290                 295                 300                 


Gln Pro Gly Ile Cys Gly Leu Thr Asn Leu Gly Asn Thr Cys Phe Met 
305                 310                 315                 320 


Asn Ser Ala Leu Gln Cys Leu Ser Asn Val Pro Gln Leu Thr Glu Tyr 
                325                 330                 335     


Phe Leu Asn Asn Cys Tyr Leu Glu Glu Leu Asn Phe Arg Asn Pro Leu 
            340                 345                 350         


Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Asp Leu Val Lys Gln 
        355                 360                 365             


Ala Trp Ser Gly His His Arg Ser Ile Val Pro His Val Phe Lys Asn 
    370                 375                 380                 


Lys Val Gly His Phe Ala Ser Gln Phe Leu Gly Tyr Gln Gln His Asp 
385                 390                 395                 400 


Ser Gln Glu Leu Leu Ser Phe Leu Leu Asp Gly Leu His Glu Asp Leu 
                405                 410                 415     


Asn Arg Val Lys Lys Lys Glu Tyr Val Glu Leu Cys Asp Ala Ala Gly 
            420                 425                 430         


Arg Pro Asp Gln Glu Val Ala Gln Glu Ala Trp Gln Asn His Lys Arg 
        435                 440                 445             


Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu Phe Lys Ser 
    450                 455                 460                 


Thr Leu Val Cys Pro Asp Cys Gly Asn Val Ser Val Thr Phe Asp Pro 
465                 470                 475                 480 


Phe Cys Tyr Leu Ser Val Pro Leu Pro Ile Ser His Lys Arg Val Leu 
                485                 490                 495     


Glu Val Phe Phe Ile Pro Met Asp Pro Arg Arg Lys Pro Glu Gln His 
            500                 505                 510         


Arg Leu Val Val Pro Lys Lys Gly Lys Ile Ser Asp Leu Cys Val Ala 
        515                 520                 525             


Leu Ser Lys His Thr Gly Ile Ser Pro Glu Arg Met Met Val Ala Asp 
    530                 535                 540                 


Val Phe Ser His Arg Phe Tyr Lys Leu Tyr Gln Leu Glu Glu Pro Leu 
545                 550                 555                 560 


Ser Ser Ile Leu Asp Arg Asp Asp Ile Phe Val Tyr Glu Val Ser Gly 
                565                 570                 575     


Arg Ile Glu Ala Ile Glu Gly Ser Arg Glu Asp Ile Val Val Pro Val 
            580                 585                 590         


Tyr Leu Arg Glu Arg Thr Pro Ala Arg Asp Tyr Asn Asn Ser Tyr Tyr 
        595                 600                 605             


Gly Leu Met Leu Phe Gly His Pro Leu Leu Val Ser Val Pro Arg Asp 
    610                 615                 620                 


Arg Phe Thr Trp Glu Gly Leu Tyr Asn Val Leu Met Tyr Arg Leu Ser 
625                 630                 635                 640 


Arg Tyr Val Thr Lys Pro Asn Ser Asp Asp Glu Asp Asp Gly Asp Glu 
                645                 650                 655     


Lys Glu Asp Asp Glu Glu Asp Lys Asp Asp Val Pro Gly Pro Ser Thr 
            660                 665                 670         


Gly Gly Ser Leu Arg Asp Pro Glu Pro Glu Gln Ala Gly Pro Ser Ser 
        675                 680                 685             


Gly Val Thr Asn Arg Cys Pro Phe Leu Leu Asp Asn Cys Leu Gly Thr 
    690                 695                 700                 


Ser Gln Trp Pro Pro Arg Arg Arg Arg Lys Gln Leu Phe Thr Leu Gln 
705                 710                 715                 720 


Thr Val Asn Ser Asn Gly Thr Ser Asp Arg Thr Thr Ser Pro Glu Glu 
                725                 730                 735     


Val His Ala Gln Pro Tyr Ile Ala Ile Asp Trp Glu Pro Glu Met Lys 
            740                 745                 750         


Lys Arg Tyr Tyr Asp Glu Val Glu Ala Glu Gly Tyr Val Lys His Asp 
        755                 760                 765             


Cys Val Gly Tyr Val Met Lys Lys Ala Pro Val Arg Leu Gln Glu Cys 
    770                 775                 780                 


Ile Glu Leu Phe Thr Thr Val Glu Thr Leu Glu Lys Glu Asn Pro Trp 
785                 790                 795                 800 


Tyr Cys Pro Ser Cys Lys Gln His Gln Leu Ala Thr Lys Lys Leu Asp 
                805                 810                 815     


Leu Trp Met Leu Pro Glu Ile Leu Ile Ile His Leu Lys Arg Phe Ser 
            820                 825                 830         


Tyr Thr Lys Phe Ser Arg Glu Lys Leu Asp Thr Leu Val Glu Phe Pro 
        835                 840                 845             


Ile Arg Asp Leu Asp Phe Ser Glu Phe Val Ile Gln Pro Gln Asn Glu 
    850                 855                 860                 


Ser Asn Pro Glu Leu Tyr Lys Tyr Asp Leu Ile Ala Val Ser Asn His 
865                 870                 875                 880 


Tyr Gly Gly Met Arg Asp Gly His Tyr Thr Thr Phe Ala Cys Asn Lys 
                885                 890                 895     


Asp Ser Gly Gln Trp His Tyr Phe Asp Asp Asn Ser Val Ser Pro Val 
            900                 905                 910         


Asn Glu Asn Gln Ile Glu Ser Lys Ala Ala Tyr Val Leu Phe Tyr Gln 
        915                 920                 925             


Arg Gln Asp Val Ala Arg Arg Leu Leu Ser Pro Ala Gly Ser Ser Gly 
    930                 935                 940                 


Ala Pro Ala Ser Pro Ala Cys Ser Ser Pro Pro Ser Ser Glu Phe Met 
945                 950                 955                 960 


Asp Val Asn 
            


<210> 23
<211> 530
<212> PRT
<213> Homo sapiens

<400> 23
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Cys Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Val Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Ile Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Gly Lys Val Glu Gly Thr Leu Pro Pro Asn Ala Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ala Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 24
<211> 494
<212> PRT
<213> Homo sapiens

<400> 24
Met Pro Leu Tyr Ser Val Thr Val Lys Trp Gly Lys Glu Lys Phe Glu 
1               5                   10                  15      


Gly Val Glu Leu Asn Thr Asp Glu Pro Pro Met Val Phe Lys Ala Gln 
            20                  25                  30          


Leu Phe Ala Leu Thr Gly Val Gln Pro Ala Arg Gln Lys Val Met Val 
        35                  40                  45              


Lys Gly Gly Thr Leu Lys Asp Asp Asp Trp Gly Asn Ile Lys Ile Lys 
    50                  55                  60                  


Asn Gly Met Thr Leu Leu Met Met Gly Ser Ala Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Glu Pro Ser Ala Lys Thr Val Phe Val Glu Asp Met Thr Glu Glu Gln 
                85                  90                  95      


Leu Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn 
            100                 105                 110         


Thr Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu 
        115                 120                 125             


Leu Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly 
    130                 135                 140                 


Glu Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe 
145                 150                 155                 160 


Asp Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu 
                165                 170                 175     


Gln Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln 
            180                 185                 190         


Gly Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met 
        195                 200                 205             


Arg Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys 
    210                 215                 220                 


Glu Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys 
225                 230                 235                 240 


Ser Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys 
                245                 250                 255     


Cys Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln 
            260                 265                 270         


Leu Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr 
        275                 280                 285             


Gly Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr 
    290                 295                 300                 


Leu Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu 
305                 310                 315                 320 


Pro Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys 
                325                 330                 335     


Glu Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met 
            340                 345                 350         


Leu Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val 
        355                 360                 365             


Ser Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln 
    370                 375                 380                 


Gln Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys 
385                 390                 395                 400 


Tyr Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly 
                405                 410                 415     


Tyr Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser 
            420                 425                 430         


Ser Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile 
        435                 440                 445             


Lys Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu 
    450                 455                 460                 


Arg Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr 
465                 470                 475                 480 


Gly Pro Arg Arg Val Glu Ile Met Glu Glu Glu Ser Glu Gln 
                485                 490                 


<210> 25
<211> 963
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Glu Gly Gly Gly Cys Arg Glu Arg Pro Asp Ala Glu Thr Gln 
1               5                   10                  15      


Lys Ser Glu Leu Gly Pro Leu Met Arg Thr Thr Leu Gln Arg Gly Ala 
            20                  25                  30          


Gln Trp Tyr Leu Ile Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr 
        35                  40                  45              


Val Gly Phe Asp Ser Trp Asp Met Tyr Asn Val Gly Glu His Asn Leu 
    50                  55                  60                  


Phe Pro Gly Pro Ile Asp Asn Ser Gly Leu Phe Ser Asp Pro Glu Ser 
65                  70                  75                  80  


Gln Thr Leu Lys Glu His Leu Ile Asp Glu Leu Asp Tyr Val Leu Val 
                85                  90                  95      


Pro Thr Glu Ala Trp Asn Lys Leu Leu Asn Trp Tyr Gly Cys Val Glu 
            100                 105                 110         


Gly Gln Gln Pro Ile Val Arg Lys Val Val Glu His Gly Leu Phe Val 
        115                 120                 125             


Lys His Cys Lys Val Glu Val Tyr Leu Leu Glu Leu Lys Leu Cys Glu 
    130                 135                 140                 


Asn Ser Asp Pro Thr Asn Val Leu Ser Cys His Phe Ser Lys Ala Asp 
145                 150                 155                 160 


Thr Ile Ala Thr Ile Glu Lys Glu Met Arg Lys Leu Phe Asn Ile Pro 
                165                 170                 175     


Ala Glu Arg Glu Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Tyr 
            180                 185                 190         


Glu Gln Leu Ser Lys Leu Asp Asn Thr Val Gln Asp Ala Gly Leu Tyr 
        195                 200                 205             


Gln Gly Gln Val Leu Val Ile Glu Pro Gln Asn Glu Asp Gly Thr Trp 
    210                 215                 220                 


Pro Arg Gln Thr Leu Gln Ser Lys Ser Ser Thr Ala Pro Ser Arg Asn 
225                 230                 235                 240 


Phe Thr Thr Ser Pro Lys Ser Ser Ala Ser Pro Tyr Ser Ser Val Ser 
                245                 250                 255     


Ala Ser Leu Ile Ala Asn Gly Asp Ser Thr Ser Thr Cys Gly Met His 
            260                 265                 270         


Ser Ser Gly Val Ser Arg Gly Gly Ser Gly Phe Ser Ala Ser Tyr Asn 
        275                 280                 285             


Cys Gln Glu Pro Pro Ser Ser His Ile Gln Pro Gly Leu Cys Gly Leu 
    290                 295                 300                 


Gly Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Leu Gln Cys Leu 
305                 310                 315                 320 


Ser Asn Thr Ala Pro Leu Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu 
                325                 330                 335     


Ala Glu Ile Asn Arg Asp Asn Pro Leu Gly Met Lys Gly Glu Ile Ala 
            340                 345                 350         


Glu Ala Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly Arg Asp Ala 
        355                 360                 365             


His Val Ala Pro Arg Met Phe Lys Thr Gln Val Gly Arg Phe Ala Pro 
    370                 375                 380                 


Gln Phe Ser Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe 
385                 390                 395                 400 


Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val Lys Lys Lys Pro 
                405                 410                 415     


Tyr Leu Glu Leu Lys Asp Ala Asn Gly Arg Pro Asp Ala Val Val Ala 
            420                 425                 430         


Lys Glu Ala Trp Glu Asn His Arg Leu Arg Asn Asp Ser Val Ile Val 
        435                 440                 445             


Asp Thr Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys Pro Glu Cys 
    450                 455                 460                 


Ala Lys Val Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro 
465                 470                 475                 480 


Leu Pro Leu Lys Lys Asp Arg Val Met Glu Val Phe Leu Val Pro Ala 
                485                 490                 495     


Asp Pro His Cys Arg Pro Thr Gln Tyr Arg Val Thr Val Pro Leu Met 
            500                 505                 510         


Gly Ala Val Ser Asp Leu Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile 
        515                 520                 525             


Ala Ala Glu Asn Met Val Val Ala Asp Val Tyr Asn His Arg Phe His 
    530                 535                 540                 


Lys Ile Phe Gln Met Asp Glu Gly Leu Asn His Ile Met Pro Arg Asp 
545                 550                 555                 560 


Asp Ile Phe Val Tyr Glu Val Cys Ser Thr Ser Val Asp Gly Ser Glu 
                565                 570                 575     


Cys Val Thr Leu Pro Val Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser 
            580                 585                 590         


Ser Thr Ser Ser Ala Ser Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser 
        595                 600                 605             


Val Pro Lys His Lys Leu Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys 
    610                 615                 620                 


Asp Arg Ile Ser Arg Tyr Val Lys Gln Pro Leu Pro Asp Glu Phe Gly 
625                 630                 635                 640 


Ser Ser Pro Leu Glu Pro Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys 
                645                 650                 655     


Glu Gly Glu Asp Glu Glu Glu Met Glu His Gln Glu Glu Gly Lys Glu 
            660                 665                 670         


Gln Leu Ser Glu Thr Glu Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp 
        675                 680                 685             


Pro Ser Glu Thr Thr Gln Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys 
    690                 695                 700                 


Arg Leu Phe Thr Phe Ser Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile 
705                 710                 715                 720 


Asn Ser Leu Ala Ala Asp Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser 
                725                 730                 735     


Thr Leu Ala Met Asp Trp Asp Ser Glu Thr Arg Arg Leu Tyr Tyr Asp 
            740                 745                 750         


Glu Gln Glu Ser Glu Ala Tyr Glu Lys His Val Ser Met Leu Gln Pro 
        755                 760                 765             


Gln Lys Lys Lys Lys Thr Thr Val Ala Leu Arg Asp Cys Ile Glu Leu 
    770                 775                 780                 


Phe Thr Thr Met Glu Thr Leu Gly Glu His Asp Pro Trp Tyr Cys Pro 
785                 790                 795                 800 


Asn Cys Lys Lys His Gln Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser 
                805                 810                 815     


Leu Pro Lys Ile Leu Val Val His Leu Lys Arg Phe Ser Tyr Asn Arg 
            820                 825                 830         


Tyr Trp Arg Asp Lys Leu Asp Thr Val Val Glu Phe Pro Ile Arg Gly 
        835                 840                 845             


Leu Asn Met Ser Glu Phe Val Cys Asn Leu Ser Ala Arg Pro Tyr Val 
    850                 855                 860                 


Tyr Asp Leu Ile Ala Val Ser Asn His Tyr Gly Ala Met Gly Val Gly 
865                 870                 875                 880 


His Tyr Thr Ala Tyr Ala Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr 
                885                 890                 895     


Phe Asp Asp Ser Asn Val Ser Leu Ala Ser Glu Asp Gln Ile Val Thr 
            900                 905                 910         


Lys Ala Ala Tyr Val Leu Phe Tyr Gln Arg Arg Asp Asp Glu Phe Tyr 
        915                 920                 925             


Lys Thr Pro Ser Leu Ser Ser Ser Gly Ser Ser Asp Gly Gly Thr Arg 
    930                 935                 940                 


Pro Ser Ser Ser Gln Gln Gly Phe Gly Asp Asp Glu Ala Cys Ser Met 
945                 950                 955                 960 


Asp Thr Asn 
            


<210> 26
<211> 913
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Ala Leu Phe Leu Arg Gly Phe Val Gln Ile Gly Asn Cys Lys 
1               5                   10                  15      


Thr Gly Ile Ser Lys Ser Lys Glu Ala Phe Ile Glu Ala Val Glu Arg 
            20                  25                  30          


Lys Lys Lys Asp Arg Leu Val Leu Tyr Phe Lys Ser Gly Lys Tyr Ser 
        35                  40                  45              


Thr Phe Arg Leu Ser Asp Asn Ile Gln Asn Val Val Leu Lys Ser Tyr 
    50                  55                  60                  


Arg Gly Asn Gln Asn His Leu His Leu Thr Leu Gln Asn Asn Asn Gly 
65                  70                  75                  80  


Leu Phe Ile Glu Gly Leu Ser Ser Thr Asp Ala Glu Gln Leu Lys Ile 
                85                  90                  95      


Phe Leu Asp Arg Val His Gln Asn Glu Val Gln Pro Pro Val Arg Pro 
            100                 105                 110         


Gly Lys Gly Gly Ser Val Phe Ser Ser Thr Thr Gln Lys Glu Ile Asn 
        115                 120                 125             


Lys Thr Ser Phe His Lys Val Asp Glu Lys Ser Ser Ser Lys Ser Phe 
    130                 135                 140                 


Glu Ile Ala Lys Gly Ser Gly Thr Gly Val Leu Gln Arg Met Pro Leu 
145                 150                 155                 160 


Leu Thr Ser Lys Leu Thr Leu Thr Cys Gly Glu Leu Ser Glu Asn Gln 
                165                 170                 175     


His Lys Lys Arg Lys Arg Met Leu Ser Ser Ser Ser Glu Met Asn Glu 
            180                 185                 190         


Glu Phe Leu Lys Glu Asn Asn Ser Val Glu Tyr Lys Lys Ser Lys Ala 
        195                 200                 205             


Asp Cys Ser Arg Cys Val Ser Tyr Asn Arg Glu Lys Gln Leu Lys Leu 
    210                 215                 220                 


Lys Glu Leu Glu Glu Asn Lys Lys Leu Glu Cys Glu Ser Ser Cys Ile 
225                 230                 235                 240 


Met Asn Ala Thr Gly Asn Pro Tyr Leu Asp Asp Ile Gly Leu Leu Gln 
                245                 250                 255     


Ala Leu Thr Glu Lys Met Val Leu Val Phe Leu Leu Gln Gln Gly Tyr 
            260                 265                 270         


Ser Asp Gly Tyr Thr Lys Trp Asp Lys Leu Lys Leu Phe Phe Glu Leu 
        275                 280                 285             


Phe Pro Glu Lys Ile Cys His Gly Leu Pro Asn Leu Gly Asn Thr Cys 
    290                 295                 300                 


Tyr Met Asn Ala Val Leu Gln Ser Leu Leu Ser Ile Pro Ser Phe Ala 
305                 310                 315                 320 


Asp Asp Leu Leu Asn Gln Ser Phe Pro Trp Gly Lys Ile Pro Leu Asn 
                325                 330                 335     


Ala Leu Thr Met Cys Leu Ala Arg Leu Leu Phe Phe Lys Asp Thr Tyr 
            340                 345                 350         


Asn Ile Glu Ile Lys Glu Met Leu Leu Leu Asn Leu Lys Lys Ala Ile 
        355                 360                 365             


Ser Ala Ala Ala Glu Ile Phe His Gly Asn Ala Gln Asn Asp Ala His 
    370                 375                 380                 


Glu Phe Leu Ala His Cys Leu Asp Gln Leu Lys Asp Asn Met Glu Lys 
385                 390                 395                 400 


Leu Asn Thr Ile Trp Lys Pro Lys Ser Glu Phe Gly Glu Asp Asn Phe 
                405                 410                 415     


Pro Lys Gln Val Phe Ala Asp Asp Pro Asp Thr Ser Gly Phe Ser Cys 
            420                 425                 430         


Pro Val Ile Thr Asn Phe Glu Leu Glu Leu Leu His Ser Ile Ala Cys 
        435                 440                 445             


Lys Ala Cys Gly Gln Val Ile Leu Lys Thr Glu Leu Asn Asn Tyr Leu 
    450                 455                 460                 


Ser Ile Asn Leu Pro Gln Arg Ile Lys Ala His Pro Ser Ser Ile Gln 
465                 470                 475                 480 


Ser Thr Phe Asp Leu Phe Phe Gly Ala Glu Glu Leu Glu Tyr Lys Cys 
                485                 490                 495     


Ala Lys Cys Glu His Lys Thr Ser Val Gly Val His Ser Phe Ser Arg 
            500                 505                 510         


Leu Pro Arg Ile Leu Ile Val His Leu Lys Arg Tyr Ser Leu Asn Glu 
        515                 520                 525             


Phe Cys Ala Leu Lys Lys Asn Asp Gln Glu Val Ile Ile Ser Lys Tyr 
    530                 535                 540                 


Leu Lys Val Ser Ser His Cys Asn Glu Gly Thr Arg Pro Pro Leu Pro 
545                 550                 555                 560 


Leu Ser Glu Asp Gly Glu Ile Thr Asp Phe Gln Leu Leu Lys Val Ile 
                565                 570                 575     


Arg Lys Met Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys 
            580                 585                 590         


Glu Ser Lys Asp Ile Leu Ala Pro His Ile Gly Ser Asp Lys Glu Ser 
        595                 600                 605             


Glu Gln Lys Lys Gly Gln Thr Val Phe Lys Gly Ala Ser Arg Arg Gln 
    610                 615                 620                 


Gln Gln Lys Tyr Leu Gly Lys Asn Ser Lys Pro Asn Glu Leu Glu Ser 
625                 630                 635                 640 


Val Tyr Ser Gly Asp Arg Ala Phe Ile Glu Lys Glu Pro Leu Ala His 
                645                 650                 655     


Leu Met Thr Tyr Leu Glu Asp Thr Ser Leu Cys Gln Phe His Lys Ala 
            660                 665                 670         


Gly Gly Lys Pro Ala Ser Ser Pro Gly Thr Pro Leu Ser Lys Val Asp 
        675                 680                 685             


Phe Gln Thr Val Pro Glu Asn Pro Lys Arg Lys Lys Tyr Val Lys Thr 
    690                 695                 700                 


Ser Lys Phe Val Ala Phe Asp Arg Ile Ile Asn Pro Thr Lys Asp Leu 
705                 710                 715                 720 


Tyr Glu Asp Lys Asn Ile Arg Ile Pro Glu Arg Phe Gln Lys Val Ser 
                725                 730                 735     


Glu Gln Thr Gln Gln Cys Asp Gly Met Arg Ile Cys Glu Gln Ala Pro 
            740                 745                 750         


Gln Gln Ala Leu Pro Gln Ser Phe Pro Lys Pro Gly Thr Gln Gly His 
        755                 760                 765             


Thr Lys Asn Leu Leu Arg Pro Thr Lys Leu Asn Leu Gln Lys Ser Asn 
    770                 775                 780                 


Arg Asn Ser Leu Leu Ala Leu Gly Ser Asn Lys Asn Pro Arg Asn Lys 
785                 790                 795                 800 


Asp Ile Leu Asp Lys Ile Lys Ser Lys Ala Lys Glu Thr Lys Arg Asn 
                805                 810                 815     


Asp Asp Lys Gly Asp His Thr Tyr Arg Leu Ile Ser Val Val Ser His 
            820                 825                 830         


Leu Gly Lys Thr Leu Lys Ser Gly His Tyr Ile Cys Asp Ala Tyr Asp 
        835                 840                 845             


Phe Glu Lys Gln Ile Trp Phe Thr Tyr Asp Asp Met Arg Val Leu Gly 
    850                 855                 860                 


Ile Gln Glu Ala Gln Met Gln Glu Asp Arg Arg Cys Thr Gly Tyr Ile 
865                 870                 875                 880 


Phe Phe Tyr Met His Asn Glu Ile Phe Glu Glu Met Leu Lys Arg Glu 
                885                 890                 895     


Glu Asn Ala Gln Leu Asn Ser Lys Glu Val Glu Glu Thr Leu Gln Lys 
            900                 905                 910         


Glu 
    


<210> 27
<211> 1318
<212> PRT
<213> Homo sapiens

<400> 27
Met Ser Gly Gly Ala Ser Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly 
1               5                   10                  15      


Leu Glu Asp Thr Thr Ser Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln 
            20                  25                  30          


Glu Ser Lys Asp Gly Asp Pro Arg Lys Glu Thr Gly Ser Arg Tyr Val 
        35                  40                  45              


Ala Gln Ala Gly Leu Glu Pro Leu Ala Ser Gly Asp Pro Ser Ala Ser 
    50                  55                  60                  


Ala Ser His Ala Ala Gly Ile Thr Gly Ser Arg His Arg Thr Arg Leu 
65                  70                  75                  80  


Phe Phe Pro Ser Ser Ser Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln 
                85                  90                  95      


Thr Lys Glu Gly Ala Cys Glu Asp Pro His Asp Leu Leu Ala Thr Pro 
            100                 105                 110         


Thr Pro Glu Leu Leu Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile 
        115                 120                 125             


Val Lys Leu Arg Val Gly Val Gly Pro Leu Gln Leu Glu Asp Val Asp 
    130                 135                 140                 


Ala Ala Phe Thr Asp Thr Asp Cys Val Val Arg Phe Ala Gly Gly Gln 
145                 150                 155                 160 


Gln Trp Gly Gly Val Phe Tyr Ala Glu Ile Lys Ser Ser Cys Ala Lys 
                165                 170                 175     


Val Gln Thr Arg Lys Gly Ser Leu Leu His Leu Thr Leu Pro Lys Lys 
            180                 185                 190         


Val Pro Met Leu Thr Trp Pro Ser Leu Leu Val Glu Ala Asp Glu Gln 
        195                 200                 205             


Leu Cys Ile Pro Pro Leu Asn Ser Gln Thr Cys Leu Leu Gly Ser Glu 
    210                 215                 220                 


Glu Asn Leu Ala Pro Leu Ala Gly Glu Lys Ala Val Pro Pro Gly Asn 
225                 230                 235                 240 


Asp Pro Val Ser Pro Ala Met Val Arg Ser Arg Asn Pro Gly Lys Asp 
                245                 250                 255     


Asp Cys Ala Lys Glu Glu Met Ala Val Ala Ala Asp Ala Ala Thr Leu 
            260                 265                 270         


Val Asp Glu Pro Glu Ser Met Val Asn Leu Ala Phe Val Lys Asn Asp 
        275                 280                 285             


Ser Tyr Glu Lys Gly Pro Asp Ser Val Val Val His Val Tyr Val Lys 
    290                 295                 300                 


Glu Ile Cys Arg Asp Thr Ser Arg Val Leu Phe Arg Glu Gln Asp Phe 
305                 310                 315                 320 


Thr Leu Ile Phe Gln Thr Arg Asp Gly Asn Phe Leu Arg Leu His Pro 
                325                 330                 335     


Gly Cys Gly Pro His Thr Thr Phe Arg Trp Gln Val Lys Leu Arg Asn 
            340                 345                 350         


Leu Ile Glu Pro Glu Gln Cys Thr Phe Cys Phe Thr Ala Ser Arg Ile 
        355                 360                 365             


Asp Ile Cys Leu Arg Lys Arg Gln Ser Gln Arg Trp Gly Gly Leu Glu 
    370                 375                 380                 


Ala Pro Ala Ala Arg Val Gly Gly Ala Lys Val Ala Val Pro Thr Gly 
385                 390                 395                 400 


Pro Thr Pro Leu Asp Ser Thr Pro Pro Gly Gly Ala Pro His Pro Leu 
                405                 410                 415     


Thr Gly Gln Glu Glu Ala Arg Ala Val Glu Lys Asp Lys Ser Lys Ala 
            420                 425                 430         


Arg Ser Glu Asp Thr Gly Leu Asp Ser Val Ala Thr Arg Thr Pro Met 
        435                 440                 445             


Glu His Val Thr Pro Lys Pro Glu Thr His Leu Ala Ser Pro Lys Pro 
    450                 455                 460                 


Thr Cys Met Val Pro Pro Met Pro His Ser Pro Val Ser Gly Asp Ser 
465                 470                 475                 480 


Val Glu Glu Glu Glu Glu Glu Glu Lys Lys Val Cys Leu Pro Gly Phe 
                485                 490                 495     


Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Val Ile 
            500                 505                 510         


Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe Phe His Asp Arg 
        515                 520                 525             


Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu Gly Thr Gly Gly 
    530                 535                 540                 


Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala Leu Trp Lys Gly 
545                 550                 555                 560 


Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala Ile Val Ala Ser 
                565                 570                 575     


Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp Ala Gln Glu Phe 
            580                 585                 590         


Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Gln 
        595                 600                 605             


Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly Arg Pro Asp Glu 
    610                 615                 620                 


Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met Arg Asn Asp Ser 
625                 630                 635                 640 


Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser Lys Leu Val Cys 
                645                 650                 655     


Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro Phe Leu Tyr Leu 
            660                 665                 670         


Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro Val Phe Tyr Phe 
        675                 680                 685             


Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu Val Ser Val Ser 
    690                 695                 700                 


Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser 
705                 710                 715                 720 


Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu Val Ile Lys Asn 
                725                 730                 735     


Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu Asp Thr Val Ser 
            740                 745                 750         


Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser Ser Glu Leu Ala 
        755                 760                 765             


Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg Pro Gln Val Pro 
    770                 775                 780                 


Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg Lys Gln Gln Ser 
785                 790                 795                 800 


Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr Arg Val Gly Tyr 
                805                 810                 815     


Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp His Lys Gly Leu 
            820                 825                 830         


Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val Ser Val Pro Ala 
        835                 840                 845             


Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu Glu Gly Tyr Ala 
    850                 855                 860                 


Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln Pro Gly Arg Met 
865                 870                 875                 880 


Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu Leu Ser Thr Gly 
                885                 890                 895     


Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile Gln Pro Pro Glu 
            900                 905                 910         


Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr Gly Leu Pro Arg 
        915                 920                 925             


Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser Thr Ser Gly Ile 
    930                 935                 940                 


Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val Gly Ser Leu Pro 
945                 950                 955                 960 


Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val Pro Gly Tyr Gln 
                965                 970                 975     


His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln Phe Phe Ile Tyr 
            980                 985                 990         


Lys Ile Asp Ser Ser Asn Arg Glu  Gln Arg Leu Glu Asp  Lys Gly Asp 
        995                 1000                 1005             


Thr Pro  Leu Glu Leu Gly Asp  Asp Cys Ser Leu Ala  Leu Val Trp 
    1010                 1015                 1020             


Arg Asn  Asn Glu Arg Leu Gln  Glu Phe Val Leu Val  Ala Ser Lys 
    1025                 1030                 1035             


Glu Leu  Glu Cys Ala Glu Asp  Pro Gly Ser Ala Gly  Glu Ala Ala 
    1040                 1045                 1050             


Arg Ala  Gly His Phe Thr Leu  Asp Gln Cys Leu Asn  Leu Phe Thr 
    1055                 1060                 1065             


Arg Pro  Glu Val Leu Ala Pro  Glu Glu Ala Trp Tyr  Cys Pro Gln 
    1070                 1075                 1080             


Cys Lys  Gln His Arg Glu Ala  Ser Lys Gln Leu Leu  Leu Trp Arg 
    1085                 1090                 1095             


Leu Pro  Asn Val Leu Ile Val  Gln Leu Lys Arg Phe  Ser Phe Arg 
    1100                 1105                 1110             


Ser Phe  Ile Trp Arg Asp Lys  Ile Asn Asp Leu Val  Glu Phe Pro 
    1115                 1120                 1125             


Val Arg  Asn Leu Asp Leu Ser  Lys Phe Cys Ile Gly  Gln Lys Glu 
    1130                 1135                 1140             


Glu Gln  Leu Pro Ser Tyr Asp  Leu Tyr Ala Val Ile  Asn His Tyr 
    1145                 1150                 1155             


Gly Gly  Met Ile Gly Gly His  Tyr Thr Ala Cys Ala  Arg Leu Pro 
    1160                 1165                 1170             


Asn Asp  Arg Ser Ser Gln Arg  Ser Asp Val Gly Trp  Arg Leu Phe 
    1175                 1180                 1185             


Asp Asp  Ser Thr Val Thr Thr  Val Asp Glu Ser Gln  Val Val Thr 
    1190                 1195                 1200             


Arg Tyr  Ala Tyr Val Leu Phe  Tyr Arg Arg Arg Asn  Ser Pro Val 
    1205                 1210                 1215             


Glu Arg  Pro Pro Arg Ala Gly  His Ser Glu His His  Pro Asp Leu 
    1220                 1225                 1230             


Gly Pro  Ala Ala Glu Ala Ala  Ala Ser Gln Ala Ser  Arg Ile Trp 
    1235                 1240                 1245             


Gln Glu  Leu Glu Ala Glu Glu  Glu Pro Val Pro Glu  Gly Ser Gly 
    1250                 1255                 1260             


Pro Leu  Gly Pro Trp Gly Pro  Gln Asp Trp Val Gly  Pro Leu Pro 
    1265                 1270                 1275             


Arg Gly  Pro Thr Thr Pro Asp  Glu Gly Cys Leu Arg  Tyr Phe Val 
    1280                 1285                 1290             


Leu Gly  Thr Val Ala Ala Leu  Val Ala Leu Val Leu  Asn Val Phe 
    1295                 1300                 1305             


Tyr Pro  Leu Val Ser Gln Ser  Arg Trp Arg 
    1310                 1315             


<210> 28
<211> 798
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Leu His Ser Pro Gln Tyr Ile Phe Gly Asp Phe Ser Pro Asp 
1               5                   10                  15      


Glu Phe Asn Gln Phe Phe Val Thr Pro Arg Ser Ser Val Glu Leu Pro 
            20                  25                  30          


Pro Tyr Ser Gly Thr Val Leu Cys Gly Thr Gln Ala Val Asp Lys Leu 
        35                  40                  45              


Pro Asp Gly Gln Glu Tyr Gln Arg Ile Glu Phe Gly Val Asp Glu Val 
    50                  55                  60                  


Ile Glu Pro Ser Asp Thr Leu Pro Arg Thr Pro Ser Tyr Ser Ile Ser 
65                  70                  75                  80  


Ser Thr Leu Asn Pro Gln Ala Pro Glu Phe Ile Leu Gly Cys Thr Ala 
                85                  90                  95      


Ser Lys Ile Thr Pro Asp Gly Ile Thr Lys Glu Ala Ser Tyr Gly Ser 
            100                 105                 110         


Ile Asp Cys Gln Tyr Pro Gly Ser Ala Leu Ala Leu Asp Gly Ser Ser 
        115                 120                 125             


Asn Val Glu Ala Glu Val Leu Glu Asn Asp Gly Val Ser Gly Gly Leu 
    130                 135                 140                 


Gly Gln Arg Glu Arg Lys Lys Lys Lys Lys Arg Pro Pro Gly Tyr Tyr 
145                 150                 155                 160 


Ser Tyr Leu Lys Asp Gly Gly Asp Asp Ser Ile Ser Thr Glu Ala Leu 
                165                 170                 175     


Val Asn Gly His Ala Asn Ser Ala Val Pro Asn Ser Val Ser Ala Glu 
            180                 185                 190         


Asp Ala Glu Phe Met Gly Asp Met Pro Pro Ser Val Thr Pro Arg Thr 
        195                 200                 205             


Cys Asn Ser Pro Gln Asn Ser Thr Asp Ser Val Ser Asp Ile Val Pro 
    210                 215                 220                 


Asp Ser Pro Phe Pro Gly Ala Leu Gly Ser Asp Thr Arg Thr Ala Gly 
225                 230                 235                 240 


Gln Pro Glu Gly Gly Pro Gly Ala Asp Phe Gly Gln Ser Cys Phe Pro 
                245                 250                 255     


Ala Glu Ala Gly Arg Asp Thr Leu Ser Arg Thr Ala Gly Ala Gln Pro 
            260                 265                 270         


Cys Val Gly Thr Asp Thr Thr Glu Asn Leu Gly Val Ala Asn Gly Gln 
        275                 280                 285             


Ile Leu Glu Ser Ser Gly Glu Gly Thr Ala Thr Asn Gly Val Glu Leu 
    290                 295                 300                 


His Thr Thr Glu Ser Ile Asp Leu Asp Pro Thr Lys Pro Glu Ser Ala 
305                 310                 315                 320 


Ser Pro Pro Ala Asp Gly Thr Gly Ser Ala Ser Gly Thr Leu Pro Val 
                325                 330                 335     


Ser Gln Pro Lys Ser Trp Ala Ser Leu Phe His Asp Ser Lys Pro Ser 
            340                 345                 350         


Ser Ser Ser Pro Val Ala Tyr Val Glu Thr Lys Tyr Ser Pro Pro Ala 
        355                 360                 365             


Ile Ser Pro Leu Val Ser Glu Lys Gln Val Glu Val Lys Glu Gly Leu 
    370                 375                 380                 


Val Pro Val Ser Glu Asp Pro Val Ala Ile Lys Ile Ala Glu Leu Leu 
385                 390                 395                 400 


Glu Asn Val Thr Leu Ile His Lys Pro Val Ser Leu Gln Pro Arg Gly 
                405                 410                 415     


Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile Asn Ala Thr Leu Gln Ala 
            420                 425                 430         


Leu Val Ala Cys Pro Pro Met Tyr His Leu Met Lys Phe Ile Pro Leu 
        435                 440                 445             


Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser Thr Pro Met Ile Asp Ser 
    450                 455                 460                 


Phe Val Arg Leu Met Asn Glu Phe Thr Asn Met Pro Val Pro Pro Lys 
465                 470                 475                 480 


Pro Arg Gln Ala Leu Gly Asp Lys Ile Val Arg Asp Ile Arg Pro Gly 
                485                 490                 495     


Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg Leu Leu Thr Val Asn Lys 
            500                 505                 510         


Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu Asp Ala Glu Glu Tyr Leu 
        515                 520                 525             


Gly Phe Ile Leu Asn Gly Leu His Glu Glu Met Leu Asn Leu Lys Lys 
    530                 535                 540                 


Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr Ile Ser Asn Gly Pro Lys 
545                 550                 555                 560 


Asn His Ser Val Asn Glu Glu Glu Gln Glu Glu Gln Gly Glu Gly Ser 
                565                 570                 575     


Glu Asp Glu Trp Glu Gln Val Gly Pro Arg Asn Lys Thr Ser Val Thr 
            580                 585                 590         


Arg Gln Ala Asp Phe Val Gln Thr Pro Ile Thr Gly Ile Phe Gly Gly 
        595                 600                 605             


His Ile Arg Ser Val Val Tyr Gln Gln Ser Ser Lys Glu Ser Ala Thr 
    610                 615                 620                 


Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp Ile Gln Ser Asp Lys Ile 
625                 630                 635                 640 


Arg Thr Val Gln Asp Ala Leu Glu Ser Leu Val Ala Arg Glu Ser Val 
                645                 650                 655     


Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu Val Glu Ile Ser Arg Arg 
            660                 665                 670         


Val Thr Leu Glu Lys Leu Pro Pro Val Leu Val Leu His Leu Lys Arg 
        675                 680                 685             


Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln Lys Leu Ile Lys Asn Ile 
    690                 695                 700                 


Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys Glu Leu Leu Ser Pro Gly 
705                 710                 715                 720 


Val Lys Asn Lys Asn Phe Lys Cys His Arg Thr Tyr Arg Leu Phe Ala 
                725                 730                 735     


Val Val Tyr His His Gly Asn Ser Ala Thr Gly Gly His Tyr Thr Thr 
            740                 745                 750         


Asp Val Phe Gln Ile Gly Leu Asn Gly Trp Leu Arg Ile Asp Asp Gln 
        755                 760                 765             


Thr Val Lys Val Ile Asn Gln Tyr Gln Val Val Lys Pro Thr Ala Glu 
    770                 775                 780                 


Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg Val Asp Leu Leu 
785                 790                 795             


<210> 29
<211> 688
<212> PRT
<213> Homo sapiens

<400> 29
Met Asp Arg Cys Lys His Val Gly Arg Leu Arg Leu Ala Gln Asp His 
1               5                   10                  15      


Ser Ile Leu Asn Pro Gln Lys Trp Cys Cys Leu Glu Cys Ala Thr Thr 
            20                  25                  30          


Glu Ser Val Trp Ala Cys Leu Lys Cys Ser His Val Ala Cys Gly Arg 
        35                  40                  45              


Tyr Ile Glu Asp His Ala Leu Lys His Phe Glu Glu Thr Gly His Pro 
    50                  55                  60                  


Leu Ala Met Glu Val Arg Asp Leu Tyr Val Phe Cys Tyr Leu Cys Lys 
65                  70                  75                  80  


Asp Tyr Val Leu Asn Asp Asn Pro Glu Gly Asp Leu Lys Leu Leu Arg 
                85                  90                  95      


Ser Ser Leu Leu Ala Val Arg Gly Gln Lys Gln Asp Thr Pro Val Arg 
            100                 105                 110         


Arg Gly Arg Thr Leu Arg Ser Met Ala Ser Gly Glu Asp Val Val Leu 
        115                 120                 125             


Pro Gln Arg Ala Pro Gln Gly Gln Pro Gln Met Leu Thr Ala Leu Trp 
    130                 135                 140                 


Tyr Arg Arg Gln Arg Leu Leu Ala Arg Thr Leu Arg Leu Trp Phe Glu 
145                 150                 155                 160 


Lys Ser Ser Arg Gly Gln Ala Lys Leu Glu Gln Arg Arg Gln Glu Glu 
                165                 170                 175     


Ala Leu Glu Arg Lys Lys Glu Glu Ala Arg Arg Arg Arg Arg Glu Val 
            180                 185                 190         


Lys Arg Arg Leu Leu Glu Glu Leu Ala Ser Thr Pro Pro Arg Lys Ser 
        195                 200                 205             


Ala Arg Leu Leu Leu His Thr Pro Arg Asp Ala Gly Pro Ala Ala Ser 
    210                 215                 220                 


Arg Pro Ala Ala Leu Pro Thr Ser Arg Arg Val Pro Ala Ala Thr Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Gln Pro Ala Met Ala Pro Gly Val Thr Gly Leu Arg 
                245                 250                 255     


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Ile Leu Gln Val Leu Ser 
            260                 265                 270         


His Leu Gln Lys Phe Arg Glu Cys Phe Leu Asn Leu Asp Pro Ser Lys 
        275                 280                 285             


Thr Glu His Leu Phe Pro Lys Ala Thr Asn Gly Lys Thr Gln Leu Ser 
    290                 295                 300                 


Gly Lys Pro Thr Asn Ser Ser Ala Thr Glu Leu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Arg Ala Glu Ala Cys Glu Arg Glu Gly Phe Cys Trp Asn Gly Arg Ala 
                325                 330                 335     


Ser Ile Ser Arg Ser Leu Glu Leu Ile Gln Asn Lys Glu Pro Ser Ser 
            340                 345                 350         


Lys His Ile Ser Leu Cys Arg Glu Leu His Thr Leu Phe Arg Val Met 
        355                 360                 365             


Trp Ser Gly Lys Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser 
    370                 375                 380                 


Val Trp Ser Leu Ile Pro Ala Phe Arg Gly Tyr Asp Gln Gln Asp Ala 
385                 390                 395                 400 


Gln Glu Phe Leu Cys Glu Leu Leu His Lys Val Gln Gln Glu Leu Glu 
                405                 410                 415     


Ser Glu Gly Thr Thr Arg Arg Ile Leu Ile Pro Phe Ser Gln Arg Lys 
            420                 425                 430         


Leu Thr Lys Gln Val Leu Lys Val Val Asn Thr Ile Phe His Gly Gln 
        435                 440                 445             


Leu Leu Ser Gln Val Thr Cys Ile Ser Cys Asn Tyr Lys Ser Asn Thr 
    450                 455                 460                 


Ile Glu Pro Phe Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr His 
465                 470                 475                 480 


Cys Ile Glu Lys Gly Phe Val Pro Leu Asn Gln Thr Glu Cys Leu Leu 
                485                 490                 495     


Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu Ala Leu Glu Gly Arg 
            500                 505                 510         


Ile Tyr Ala Cys Asp Gln Cys Asn Ser Lys Arg Arg Lys Ser Asn Pro 
        515                 520                 525             


Lys Pro Leu Val Leu Ser Glu Ala Arg Lys Gln Leu Met Ile Tyr Arg 
    530                 535                 540                 


Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg Phe Arg Trp Ser Gly 
545                 550                 555                 560 


Arg Asn His Arg Glu Lys Ile Gly Val His Val Val Phe Asp Gln Val 
                565                 570                 575     


Leu Thr Met Glu Pro Tyr Cys Cys Arg Asp Met Leu Ser Ser Leu Asp 
            580                 585                 590         


Lys Glu Thr Phe Ala Tyr Asp Leu Ser Ala Val Val Met His His Gly 
        595                 600                 605             


Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr Cys Tyr Asn Thr Glu 
    610                 615                 620                 


Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys Leu Asn Val Cys Ser 
625                 630                 635                 640 


Val Glu Glu Val Cys Lys Thr Gln Ala Tyr Ile Leu Phe Tyr Thr Gln 
                645                 650                 655     


Arg Thr Val Gln Gly Asn Ala Arg Ile Ser Glu Thr His Leu Gln Ala 
            660                 665                 670         


Gln Val Gln Ser Ser Asn Asn Asp Glu Gly Arg Pro Gln Thr Phe Ser 
        675                 680                 685             


<210> 30
<211> 530
<212> PRT
<213> Homo sapiens

<400> 30
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Pro Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Leu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr Pro Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Cys Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly Tyr Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Glu Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Met Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Met Asn Ser Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 31
<211> 350
<212> PRT
<213> Homo sapiens

<400> 31
Gly Ser Lys Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala 
1               5                   10                  15      


Thr Cys Tyr Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln 
            20                  25                  30          


Leu Arg Lys Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser 
        35                  40                  45              


Lys Ser Val Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His 
    50                  55                  60                  


Ser Asp Lys Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp 
65                  70                  75                  80  


Glu Thr Leu Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg 
                85                  90                  95      


Val Leu Leu Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu 
            100                 105                 110         


Gly Thr Ile Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln 
        115                 120                 125             


Cys Lys Glu Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp 
    130                 135                 140                 


Ile Gln Leu Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val 
145                 150                 155                 160 


Asp Tyr Val Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala 
                165                 170                 175     


Gly Glu His Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr 
            180                 185                 190         


Leu Pro Pro Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro 
        195                 200                 205             


Gln Thr Asp Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu 
    210                 215                 220                 


Gln Leu Pro Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro 
225                 230                 235                 240 


Ala Asn Tyr Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His 
                245                 250                 255     


Gly Gly His Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp 
            260                 265                 270         


Cys Lys Phe Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala 
        275                 280                 285             


Ile Glu His Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His 
    290                 295                 300                 


Cys Thr Asn Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser 
305                 310                 315                 320 


Glu Val Leu Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val 
                325                 330                 335     


Glu Arg Leu Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg 
            340                 345                 350 


<210> 32
<211> 343
<212> PRT
<213> Homo sapiens

<400> 32
Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp Tyr 
            20                  25                  30          


Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn Ala 
        35                  40                  45              


His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile Trp 
    50                  55                  60                  


Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr Gln 
65                  70                  75                  80  


Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val Asn 
            100                 105                 110         


Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His Leu 
        115                 120                 125             


Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu Arg 
    130                 135                 140                 


Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser Ser 
145                 150                 155                 160 


Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro Phe 
                165                 170                 175     


Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val Thr 
            180                 185                 190         


Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp Gly 
        195                 200                 205             


Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys Ile 
    210                 215                 220                 


Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His Leu 
225                 230                 235                 240 


Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr Phe 
                245                 250                 255     


Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser Glu 
            260                 265                 270         


Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His Ser 
        275                 280                 285             


Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro Gly 
    290                 295                 300                 


Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met Ser 
305                 310                 315                 320 


Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu Leu 
                325                 330                 335     


Ala Ser Pro Pro Ser Arg Met 
            340             


<210> 33
<211> 374
<212> PRT
<213> Homo sapiens

<400> 33
Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr 
1               5                   10                  15      


Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser 
            20                  25                  30          


Ser Val Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Val 
        35                  40                  45              


Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile Val Asn 
    50                  55                  60                  


Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met Lys Leu 
65                  70                  75                  80  


Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe Thr Ser Glu 
                85                  90                  95      


Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His His Ile Leu 
            100                 105                 110         


Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln 
        115                 120                 125             


Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly 
    130                 135                 140                 


Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn 
145                 150                 155                 160 


Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg 
                165                 170                 175     


Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu 
            180                 185                 190         


Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile 
        195                 200                 205             


Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro 
    210                 215                 220                 


Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr 
225                 230                 235                 240 


Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val 
                245                 250                 255     


Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile 
            260                 265                 270         


Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile Glu Thr Ser 
        275                 280                 285             


His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu 
    290                 295                 300                 


Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn 
305                 310                 315                 320 


Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met 
                325                 330                 335     


Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys 
            340                 345                 350         


Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln Ser Pro 
        355                 360                 365             


Thr Met Ser Leu Tyr Lys 
    370                 


<210> 34
<211> 530
<212> PRT
<213> Homo sapiens

<400> 34
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 35
<211> 525
<212> PRT
<213> Homo sapiens

<400> 35
Met Val Ser Arg Pro Glu Pro Glu Gly Glu Ala Met Asp Ala Glu Leu 
1               5                   10                  15      


Ala Val Ala Pro Pro Gly Cys Ser His Leu Gly Ser Phe Lys Val Asp 
            20                  25                  30          


Asn Trp Lys Gln Asn Leu Arg Ala Ile Tyr Gln Cys Phe Val Trp Ser 
        35                  40                  45              


Gly Thr Ala Glu Ala Arg Lys Arg Lys Ala Lys Ser Cys Ile Cys His 
    50                  55                  60                  


Val Cys Gly Val His Leu Asn Arg Leu His Ser Cys Leu Tyr Cys Val 
65                  70                  75                  80  


Phe Phe Gly Cys Phe Thr Lys Lys His Ile His Glu His Ala Lys Ala 
                85                  90                  95      


Lys Arg His Asn Leu Ala Ile Asp Leu Met Tyr Gly Gly Ile Tyr Cys 
            100                 105                 110         


Phe Leu Cys Gln Asp Tyr Ile Tyr Asp Lys Asp Met Glu Ile Ile Ala 
        115                 120                 125             


Lys Glu Glu Gln Arg Lys Ala Trp Lys Met Gln Gly Val Gly Glu Lys 
    130                 135                 140                 


Phe Ser Thr Trp Glu Pro Thr Lys Arg Glu Leu Glu Leu Leu Lys His 
145                 150                 155                 160 


Asn Pro Lys Arg Arg Lys Ile Thr Ser Asn Cys Thr Ile Gly Leu Arg 
                165                 170                 175     


Gly Leu Ile Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln 
            180                 185                 190         


Ala Leu Thr His Thr Pro Leu Leu Arg Asp Phe Phe Leu Ser Asp Arg 
        195                 200                 205             


His Arg Cys Glu Met Gln Ser Pro Ser Ser Cys Leu Val Cys Glu Met 
    210                 215                 220                 


Ser Ser Leu Phe Gln Glu Phe Tyr Ser Gly His Arg Ser Pro His Ile 
225                 230                 235                 240 


Pro Tyr Lys Leu Leu His Leu Val Trp Thr His Ala Arg His Leu Ala 
                245                 250                 255     


Gly Tyr Glu Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp 
            260                 265                 270         


Val Leu His Arg His Cys Lys Gly Asp Asp Asn Gly Lys Lys Ala Asn 
        275                 280                 285             


Asn Pro Asn His Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly 
    290                 295                 300                 


Leu Gln Ser Asp Val Thr Cys Gln Val Cys His Gly Val Ser Thr Thr 
305                 310                 315                 320 


Ile Asp Pro Phe Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Ser Thr 
                325                 330                 335     


Pro Phe Trp Pro Leu Ser Pro Gly Ser Glu Gly Asn Val Val Asn Gly 
            340                 345                 350         


Glu Ser His Val Ser Gly Thr Thr Thr Leu Thr Asp Cys Leu Arg Arg 
        355                 360                 365             


Phe Thr Arg Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Ser 
    370                 375                 380                 


Gly Cys His Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys 
385                 390                 395                 400 


Leu Pro Ile Val Ala Cys Phe His Leu Lys Arg Phe Glu His Ser Ala 
                405                 410                 415     


Lys Leu Arg Arg Lys Ile Thr Thr Tyr Val Ser Phe Pro Leu Glu Leu 
            420                 425                 430         


Asp Met Thr Pro Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly 
        435                 440                 445             


Gln Tyr Gln Gln Pro Thr Asp Ser Leu Asn Asn Asp Asn Lys Tyr Ser 
    450                 455                 460                 


Leu Phe Ala Val Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr 
465                 470                 475                 480 


Thr Ser Phe Ile Arg Gln His Lys Asp Gln Trp Phe Lys Cys Asp Asp 
                485                 490                 495     


Ala Ile Ile Thr Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly 
            500                 505                 510         


Tyr Leu Leu Phe Tyr His Lys Gln Phe Leu Glu Tyr Glu 
        515                 520                 525 


<210> 36
<211> 372
<212> PRT
<213> Homo sapiens

<400> 36
Met Ser Lys Ala Phe Gly Leu Leu Arg Gln Ile Cys Gln Ser Ile Leu 
1               5                   10                  15      


Ala Glu Ser Ser Gln Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu 
            20                  25                  30          


Asp Ser Asn Met Lys Arg Glu Gln Pro Arg Glu Arg Pro Arg Ala Trp 
        35                  40                  45              


Asp Tyr Pro His Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Thr 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Cys Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Thr Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Thr Ile Arg Val Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp Gln Glu Thr Ala Tyr Leu Leu Val Tyr Met 
        355                 360                 365             


Lys Met Glu Cys 
    370         


<210> 37
<211> 1077
<212> PRT
<213> Homo sapiens

<400> 37
Met Thr Ala Glu Leu Gln Gln Asp Asp Ala Ala Gly Ala Ala Asp Gly 
1               5                   10                  15      


His Gly Ser Ser Cys Gln Met Leu Leu Asn Gln Leu Arg Glu Ile Thr 
            20                  25                  30          


Gly Ile Gln Asp Pro Ser Phe Leu His Glu Ala Leu Lys Ala Ser Asn 
        35                  40                  45              


Gly Asp Ile Thr Gln Ala Val Ser Leu Leu Thr Asp Glu Arg Val Lys 
    50                  55                  60                  


Glu Pro Ser Gln Asp Thr Val Ala Thr Glu Pro Ser Glu Val Glu Gly 
65                  70                  75                  80  


Ser Ala Ala Asn Lys Glu Val Leu Ala Lys Val Ile Asp Leu Thr His 
                85                  90                  95      


Asp Asn Lys Asp Asp Leu Gln Ala Ala Ile Ala Leu Ser Leu Leu Glu 
            100                 105                 110         


Ser Pro Lys Ile Gln Ala Asp Gly Arg Asp Leu Asn Arg Met His Glu 
        115                 120                 125             


Ala Thr Ser Ala Glu Thr Lys Arg Ser Lys Arg Lys Arg Cys Glu Val 
    130                 135                 140                 


Trp Gly Glu Asn Pro Asn Pro Asn Asp Trp Arg Arg Val Asp Gly Trp 
145                 150                 155                 160 


Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val 
                165                 170                 175     


Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val Leu Ser 
            180                 185                 190         


Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His Thr Glu 
        195                 200                 205             


Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe Ala Leu 
    210                 215                 220                 


Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala Leu Asp 
225                 230                 235                 240 


Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln Asp Val 
                245                 250                 255     


Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln 
            260                 265                 270         


Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn Pro Met 
        275                 280                 285             


Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg Glu Gly 
    290                 295                 300                 


Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu Gln Val 
305                 310                 315                 320 


Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met Val Glu 
                325                 330                 335     


Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr Gly Gln 
            340                 345                 350         


Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu Leu Ser 
        355                 360                 365             


Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile His Asn 
    370                 375                 380                 


Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met Tyr Arg 
385                 390                 395                 400 


Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys Leu Lys 
                405                 410                 415     


Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val Lys Tyr 
            420                 425                 430         


Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys Tyr Val 
        435                 440                 445             


Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro Pro Glu 
    450                 455                 460                 


Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys Ser Val 
465                 470                 475                 480 


Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser Ser Gln 
                485                 490                 495     


Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro Lys Ser 
            500                 505                 510         


Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser Gln Pro 
        515                 520                 525             


Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys Thr Cys 
    530                 535                 540                 


Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp Leu Lys 
545                 550                 555                 560 


Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr Cys Asp 
                565                 570                 575     


Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu Val His 
            580                 585                 590         


Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr Asn Gln 
        595                 600                 605             


Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr Glu Ser 
    610                 615                 620                 


Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg Asn Val 
625                 630                 635                 640 


Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr Phe Asn 
                645                 650                 655     


Ala Glu Ala Ala Pro Thr Glu Ser Asp Gln Met Ser Glu Val Glu Ala 
            660                 665                 670         


Leu Ser Val Glu Leu Lys His Tyr Ile Gln Glu Asp Asn Trp Arg Phe 
        675                 680                 685             


Glu Gln Glu Val Glu Glu Trp Glu Glu Glu Gln Ser Cys Lys Ile Pro 
    690                 695                 700                 


Gln Met Glu Ser Ser Thr Asn Ser Ser Ser Gln Asp Tyr Ser Thr Ser 
705                 710                 715                 720 


Gln Glu Pro Ser Val Ala Ser Ser His Gly Val Arg Cys Leu Ser Ser 
                725                 730                 735     


Glu His Ala Val Ile Val Lys Glu Gln Thr Ala Gln Ala Ile Ala Asn 
            740                 745                 750         


Thr Ala Arg Ala Tyr Glu Lys Ser Gly Val Glu Ala Ala Leu Ser Glu 
        755                 760                 765             


Val Met Leu Ser Pro Ala Met Gln Gly Val Ile Leu Ala Ile Ala Lys 
    770                 775                 780                 


Ala Arg Gln Thr Phe Asp Arg Asp Gly Ser Glu Ala Gly Leu Ile Lys 
785                 790                 795                 800 


Ala Phe His Glu Glu Tyr Ser Arg Leu Tyr Gln Leu Ala Lys Glu Thr 
                805                 810                 815     


Pro Thr Ser His Ser Asp Pro Arg Leu Gln His Val Leu Val Tyr Phe 
            820                 825                 830         


Phe Gln Asn Glu Ala Pro Lys Arg Val Val Glu Arg Thr Leu Leu Glu 
        835                 840                 845             


Gln Phe Ala Asp Lys Asn Leu Ser Tyr Asp Glu Arg Ser Ile Ser Ile 
    850                 855                 860                 


Met Lys Val Ala Gln Ala Lys Leu Lys Glu Ile Gly Pro Asp Asp Met 
865                 870                 875                 880 


Asn Met Glu Glu Tyr Lys Lys Trp His Glu Asp Tyr Ser Leu Phe Arg 
                885                 890                 895     


Lys Val Ser Val Tyr Leu Leu Thr Gly Leu Glu Leu Tyr Gln Lys Gly 
            900                 905                 910         


Lys Tyr Gln Glu Ala Leu Ser Tyr Leu Val Tyr Ala Tyr Gln Ser Asn 
        915                 920                 925             


Ala Ala Leu Leu Met Lys Gly Pro Arg Arg Gly Val Lys Glu Ser Val 
    930                 935                 940                 


Ile Ala Leu Tyr Arg Arg Lys Cys Leu Leu Glu Leu Asn Ala Lys Ala 
945                 950                 955                 960 


Ala Ser Leu Phe Glu Thr Asn Asp Asp His Ser Val Thr Glu Gly Ile 
                965                 970                 975     


Asn Val Met Asn Glu Leu Ile Ile Pro Cys Ile His Leu Ile Ile Asn 
            980                 985                 990         


Asn Asp Ile Ser Lys Asp Asp Leu  Asp Ala Ile Glu Val  Met Arg Asn 
        995                 1000                 1005             


His Trp  Cys Ser Tyr Leu Gly  Gln Asp Ile Ala Glu  Asn Leu Gln 
    1010                 1015                 1020             


Leu Cys  Leu Gly Glu Phe Leu  Pro Arg Leu Leu Asp  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ile  Ile Val Leu Lys Glu  Pro Pro Thr Ile Arg  Pro Asn Ser 
    1040                 1045                 1050             


Pro Tyr  Asp Leu Cys Ser Arg  Phe Ala Ala Val Met  Glu Ser Ile 
    1055                 1060                 1065             


Gln Gly  Val Ser Thr Val Thr  Val Lys 
    1070                 1075         


<210> 38
<211> 530
<212> PRT
<213> Homo sapiens

<400> 38
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Ala Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Lys Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Lys Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu Arg Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Val Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 39
<211> 1352
<212> PRT
<213> Homo sapiens

<400> 39
Met Ser Lys Val Thr Ala Pro Gly Ser Gly Pro Pro Ala Ala Ala Ser 
1               5                   10                  15      


Gly Lys Glu Lys Arg Ser Phe Ser Lys Arg Leu Phe Arg Ser Gly Arg 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Pro Gly Ala Ser Gly Pro Ala Ala 
        35                  40                  45              


Pro Ser Ser Pro Ser Ser Pro Ser Ser Ala Arg Ser Val Gly Ser Phe 
    50                  55                  60                  


Met Ser Arg Val Leu Lys Thr Leu Ser Thr Leu Ser His Leu Ser Ser 
65                  70                  75                  80  


Glu Gly Ala Ala Pro Asp Arg Gly Gly Leu Arg Ser Cys Phe Pro Pro 
                85                  90                  95      


Gly Pro Ala Ala Ala Pro Thr Pro Pro Pro Cys Pro Pro Pro Pro Ala 
            100                 105                 110         


Ser Pro Ala Pro Pro Ala Cys Ala Ala Glu Pro Val Pro Gly Val Ala 
        115                 120                 125             


Gly Leu Arg Asn His Gly Asn Thr Cys Phe Met Asn Ala Thr Leu Gln 
    130                 135                 140                 


Cys Leu Ser Asn Thr Glu Leu Phe Ala Glu Tyr Leu Ala Leu Gly Gln 
145                 150                 155                 160 


Tyr Arg Ala Gly Arg Pro Glu Pro Ser Pro Asp Pro Glu Gln Pro Ala 
                165                 170                 175     


Gly Arg Gly Ala Gln Gly Gln Gly Glu Val Thr Glu Gln Leu Ala His 
            180                 185                 190         


Leu Val Arg Ala Leu Trp Thr Leu Glu Tyr Thr Pro Gln His Ser Arg 
        195                 200                 205             


Asp Phe Lys Thr Ile Val Ser Lys Asn Ala Leu Gln Tyr Arg Gly Asn 
    210                 215                 220                 


Ser Gln His Asp Ala Gln Glu Phe Leu Leu Trp Leu Leu Asp Arg Val 
225                 230                 235                 240 


His Glu Asp Leu Asn His Ser Val Lys Gln Ser Gly Gln Pro Pro Leu 
                245                 250                 255     


Lys Pro Pro Ser Glu Thr Asp Met Met Pro Glu Gly Pro Ser Phe Pro 
            260                 265                 270         


Val Cys Ser Thr Phe Val Gln Glu Leu Phe Gln Ala Gln Tyr Arg Ser 
        275                 280                 285             


Ser Leu Thr Cys Pro His Cys Gln Lys Gln Ser Asn Thr Phe Asp Pro 
    290                 295                 300                 


Phe Leu Cys Ile Ser Leu Pro Ile Pro Leu Pro His Thr Arg Pro Leu 
305                 310                 315                 320 


Tyr Val Thr Val Val Tyr Gln Gly Lys Cys Ser His Cys Met Arg Ile 
                325                 330                 335     


Gly Val Ala Val Pro Leu Ser Gly Thr Val Ala Arg Leu Arg Glu Ala 
            340                 345                 350         


Val Ser Met Glu Thr Lys Ile Pro Thr Asp Gln Ile Val Leu Thr Glu 
        355                 360                 365             


Met Tyr Tyr Asp Gly Phe His Arg Ser Phe Cys Asp Thr Asp Asp Leu 
    370                 375                 380                 


Glu Thr Val His Glu Ser Asp Cys Ile Phe Ala Phe Glu Thr Pro Glu 
385                 390                 395                 400 


Ile Phe Arg Pro Glu Gly Ile Leu Ser Gln Arg Gly Ile His Leu Asn 
                405                 410                 415     


Asn Asn Leu Asn His Leu Lys Phe Gly Leu Asp Tyr His Arg Leu Ser 
            420                 425                 430         


Ser Pro Thr Gln Thr Ala Ala Lys Gln Gly Lys Met Asp Ser Pro Thr 
        435                 440                 445             


Ser Arg Ala Gly Ser Asp Lys Ile Val Leu Leu Val Cys Asn Arg Ala 
    450                 455                 460                 


Cys Thr Gly Gln Gln Gly Lys Arg Phe Gly Leu Pro Phe Val Leu His 
465                 470                 475                 480 


Leu Glu Lys Thr Ile Ala Trp Asp Leu Leu Gln Lys Glu Ile Leu Glu 
                485                 490                 495     


Lys Met Lys Tyr Phe Leu Arg Pro Thr Val Cys Ile Gln Val Cys Pro 
            500                 505                 510         


Phe Ser Leu Arg Val Val Ser Val Val Gly Ile Thr Tyr Leu Leu Pro 
        515                 520                 525             


Gln Glu Glu Gln Pro Leu Cys His Pro Ile Val Glu Arg Ala Leu Lys 
    530                 535                 540                 


Ser Cys Gly Pro Gly Gly Thr Ala His Val Lys Leu Val Val Glu Trp 
545                 550                 555                 560 


Asp Lys Glu Thr Arg Asp Phe Leu Phe Val Asn Thr Glu Asp Glu Tyr 
                565                 570                 575     


Ile Pro Asp Ala Glu Ser Val Arg Leu Gln Arg Glu Arg His His Gln 
            580                 585                 590         


Pro Gln Thr Cys Thr Leu Ser Gln Cys Phe Gln Leu Tyr Thr Lys Glu 
        595                 600                 605             


Glu Arg Leu Ala Pro Asp Asp Ala Trp Arg Cys Pro His Cys Lys Gln 
    610                 615                 620                 


Leu Gln Gln Gly Ser Ile Thr Leu Ser Leu Trp Thr Leu Pro Asp Val 
625                 630                 635                 640 


Leu Ile Ile His Leu Lys Arg Phe Arg Gln Glu Gly Asp Arg Arg Met 
                645                 650                 655     


Lys Leu Gln Asn Met Val Lys Phe Pro Leu Thr Gly Leu Asp Met Thr 
            660                 665                 670         


Pro His Val Val Lys Arg Ser Gln Ser Ser Trp Ser Leu Pro Ser His 
        675                 680                 685             


Trp Ser Pro Trp Arg Arg Pro Tyr Gly Leu Gly Arg Asp Pro Glu Asp 
    690                 695                 700                 


Tyr Ile Tyr Asp Leu Tyr Ala Val Cys Asn His His Gly Thr Met Gln 
705                 710                 715                 720 


Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn Ser Val Asp Gly Leu Trp 
                725                 730                 735     


Tyr Cys Phe Asp Asp Ser Asp Val Gln Gln Leu Ser Glu Asp Glu Val 
            740                 745                 750         


Cys Thr Gln Thr Ala Tyr Ile Leu Phe Tyr Gln Arg Arg Thr Ala Ile 
        755                 760                 765             


Pro Ser Trp Ser Ala Asn Ser Ser Val Ala Gly Ser Thr Ser Ser Ser 
    770                 775                 780                 


Leu Cys Glu His Trp Val Ser Arg Leu Pro Gly Ser Lys Pro Ala Ser 
785                 790                 795                 800 


Val Thr Ser Ala Ala Ser Ser Arg Arg Thr Ser Leu Ala Ser Leu Ser 
                805                 810                 815     


Glu Ser Val Glu Met Thr Gly Glu Arg Ser Glu Asp Asp Gly Gly Phe 
            820                 825                 830         


Ser Thr Arg Pro Phe Val Arg Ser Val Gln Arg Gln Ser Leu Ser Ser 
        835                 840                 845             


Arg Ser Ser Val Thr Ser Pro Leu Ala Val Asn Glu Asn Cys Met Arg 
    850                 855                 860                 


Pro Ser Trp Ser Leu Ser Ala Lys Leu Gln Met Arg Ser Asn Ser Pro 
865                 870                 875                 880 


Ser Arg Phe Ser Gly Asp Ser Pro Ile His Ser Ser Ala Ser Thr Leu 
                885                 890                 895     


Glu Lys Ile Gly Glu Ala Ala Asp Asp Lys Val Ser Ile Ser Cys Phe 
            900                 905                 910         


Gly Ser Leu Arg Asn Leu Ser Ser Ser Tyr Gln Glu Pro Ser Asp Ser 
        915                 920                 925             


His Ser Arg Arg Glu His Lys Ala Val Gly Arg Ala Pro Leu Ala Val 
    930                 935                 940                 


Met Glu Gly Val Phe Lys Asp Glu Ser Asp Thr Arg Arg Leu Asn Ser 
945                 950                 955                 960 


Ser Val Val Asp Thr Gln Ser Lys His Ser Ala Gln Gly Asp Arg Leu 
                965                 970                 975     


Pro Pro Leu Ser Gly Pro Phe Asp Asn Asn Asn Gln Ile Ala Tyr Val 
            980                 985                 990         


Asp Gln Ser Asp Ser Val Asp Ser  Ser Pro Val Lys Glu  Val Lys Ala 
        995                 1000                 1005             


Pro Ser  His Pro Gly Ser Leu  Ala Lys Lys Pro Glu  Ser Thr Thr 
    1010                 1015                 1020             


Lys Arg  Ser Pro Ser Ser Lys  Gly Thr Ser Glu Pro  Glu Lys Ser 
    1025                 1030                 1035             


Leu Arg  Lys Gly Arg Pro Ala  Leu Ala Ser Gln Glu  Ser Ser Leu 
    1040                 1045                 1050             


Ser Ser  Thr Ser Pro Ser Ser  Pro Leu Pro Val Lys  Val Ser Leu 
    1055                 1060                 1065             


Lys Pro  Ser Arg Ser Arg Ser  Lys Ala Asp Ser Ser  Ser Arg Gly 
    1070                 1075                 1080             


Ser Gly  Arg His Ser Ser Pro  Ala Pro Ala Gln Pro  Lys Lys Glu 
    1085                 1090                 1095             


Ser Ser  Pro Lys Ser Gln Asp  Ser Val Ser Ser Pro  Ser Pro Gln 
    1100                 1105                 1110             


Lys Gln  Lys Ser Ala Ser Ala  Leu Thr Tyr Thr Ala  Ser Ser Thr 
    1115                 1120                 1125             


Ser Ala  Lys Lys Ala Ser Gly  Pro Ala Thr Arg Ser  Pro Phe Pro 
    1130                 1135                 1140             


Pro Gly  Lys Ser Arg Thr Ser  Asp His Ser Leu Ser  Arg Glu Gly 
    1145                 1150                 1155             


Ser Arg  Gln Ser Leu Gly Ser  Asp Arg Ala Ser Ala  Thr Ser Thr 
    1160                 1165                 1170             


Ser Lys  Pro Asn Ser Pro Arg  Val Ser Gln Ala Arg  Ala Gly Glu 
    1175                 1180                 1185             


Gly Arg  Gly Ala Gly Lys His  Val Arg Ser Ser Ser  Met Ala Ser 
    1190                 1195                 1200             


Leu Arg  Ser Pro Ser Thr Ser  Ile Lys Ser Gly Leu  Lys Arg Asp 
    1205                 1210                 1215             


Ser Lys  Ser Glu Asp Lys Gly  Leu Ser Phe Phe Lys  Ser Ala Leu 
    1220                 1225                 1230             


Arg Gln  Lys Glu Thr Arg Arg  Ser Thr Asp Leu Gly  Lys Thr Ala 
    1235                 1240                 1245             


Leu Leu  Ser Lys Lys Ala Gly  Gly Ser Ser Val Lys  Ser Val Cys 
    1250                 1255                 1260             


Lys Asn  Thr Gly Asp Asp Glu  Ala Glu Arg Gly His  Gln Pro Pro 
    1265                 1270                 1275             


Ala Ser  Gln Gln Pro Asn Ala  Asn Thr Thr Gly Lys  Glu Gln Leu 
    1280                 1285                 1290             


Val Thr  Lys Asp Pro Ala Ser  Ala Lys His Ser Leu  Leu Ser Ala 
    1295                 1300                 1305             


Arg Lys  Ser Lys Ser Ser Gln  Leu Asp Ser Gly Val  Pro Ser Ser 
    1310                 1315                 1320             


Pro Gly  Gly Arg Gln Ser Ala  Glu Lys Ser Ser Lys  Lys Leu Ser 
    1325                 1330                 1335             


Ser Ser  Met Gln Thr Ser Ala  Arg Pro Ser Gln Lys  Pro Gln 
    1340                 1345                 1350         


<210> 40
<211> 530
<212> PRT
<213> Homo sapiens

<400> 40
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Lys Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 41
<211> 553
<212> PRT
<213> Homo sapiens

<400> 41
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Asp Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Lys 
    290                 295                 300                 


Leu Tyr Met Ser Gln Thr Asn Ser Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln Trp Ser Gln Trp Lys Tyr Arg Pro Thr Arg Arg Gly Ala His 
    530                 535                 540                 


Thr His Ala His Thr Gln Thr His Thr 
545                 550             


<210> 42
<211> 1375
<212> PRT
<213> Homo sapiens

<400> 42
Met Val Pro Gly Glu Glu Asn Gln Leu Val Pro Lys Glu Asp Val Phe 
1               5                   10                  15      


Trp Arg Cys Arg Gln Asn Ile Phe Asp Glu Met Lys Lys Lys Phe Leu 
            20                  25                  30          


Gln Ile Glu Asn Ala Ala Glu Glu Pro Arg Val Leu Cys Ile Ile Gln 
        35                  40                  45              


Asp Thr Thr Asn Ser Lys Thr Val Asn Glu Arg Ile Thr Leu Asn Leu 
    50                  55                  60                  


Pro Ala Ser Thr Pro Val Arg Lys Leu Phe Glu Asp Val Ala Asn Lys 
65                  70                  75                  80  


Val Gly Tyr Ile Asn Gly Thr Phe Asp Leu Val Trp Gly Asn Gly Ile 
                85                  90                  95      


Asn Thr Ala Asp Met Ala Pro Leu Asp His Thr Ser Asp Lys Ser Leu 
            100                 105                 110         


Leu Asp Ala Asn Phe Glu Pro Gly Lys Lys Asn Phe Leu His Leu Thr 
        115                 120                 125             


Asp Lys Asp Gly Glu Gln Pro Gln Ile Leu Leu Glu Asp Ser Ser Ala 
    130                 135                 140                 


Gly Glu Asp Ser Val His Asp Arg Phe Ile Gly Pro Leu Pro Arg Glu 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Thr Ser Asp Tyr Val Ser Gln Ser Tyr Ser Tyr 
                165                 170                 175     


Ser Ser Ile Leu Asn Lys Ser Glu Thr Gly Tyr Val Gly Leu Val Asn 
            180                 185                 190         


Gln Ala Met Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu Phe Met 
        195                 200                 205             


Thr Pro Glu Phe Arg Asn Ala Leu Tyr Lys Trp Glu Phe Glu Glu Ser 
    210                 215                 220                 


Glu Glu Asp Pro Val Thr Ser Ile Pro Tyr Gln Leu Gln Arg Leu Phe 
225                 230                 235                 240 


Val Leu Leu Gln Thr Ser Lys Lys Arg Ala Ile Glu Thr Thr Asp Val 
                245                 250                 255     


Thr Arg Ser Phe Gly Trp Asp Ser Ser Glu Ala Trp Gln Gln His Asp 
            260                 265                 270         


Val Gln Glu Leu Cys Arg Val Met Phe Asp Ala Leu Glu Gln Lys Trp 
        275                 280                 285             


Lys Gln Thr Glu Gln Ala Asp Leu Ile Asn Glu Leu Tyr Gln Gly Lys 
    290                 295                 300                 


Leu Lys Asp Tyr Val Arg Cys Leu Glu Cys Gly Tyr Glu Gly Trp Arg 
305                 310                 315                 320 


Ile Asp Thr Tyr Leu Asp Ile Pro Leu Val Ile Arg Pro Tyr Gly Ser 
                325                 330                 335     


Ser Gln Ala Phe Ala Ser Val Glu Glu Ala Leu His Ala Phe Ile Gln 
            340                 345                 350         


Pro Glu Ile Leu Asp Gly Pro Asn Gln Tyr Phe Cys Glu Arg Cys Lys 
        355                 360                 365             


Lys Lys Cys Asp Ala Arg Lys Gly Leu Arg Phe Leu His Phe Pro Tyr 
    370                 375                 380                 


Leu Leu Thr Leu Gln Leu Lys Arg Phe Asp Phe Asp Tyr Thr Thr Met 
385                 390                 395                 400 


His Arg Ile Lys Leu Asn Asp Arg Met Thr Phe Pro Glu Glu Leu Asp 
                405                 410                 415     


Met Ser Thr Phe Ile Asp Val Glu Asp Glu Lys Ser Pro Gln Thr Glu 
            420                 425                 430         


Ser Cys Thr Asp Ser Gly Ala Glu Asn Glu Gly Ser Cys His Ser Asp 
        435                 440                 445             


Gln Met Ser Asn Asp Phe Ser Asn Asp Asp Gly Val Asp Glu Gly Ile 
    450                 455                 460                 


Cys Leu Glu Thr Asn Ser Gly Thr Glu Lys Ile Ser Lys Ser Gly Leu 
465                 470                 475                 480 


Glu Lys Asn Ser Leu Ile Tyr Glu Leu Phe Ser Val Met Val His Ser 
                485                 490                 495     


Gly Ser Ala Ala Gly Gly His Tyr Tyr Ala Cys Ile Lys Ser Phe Ser 
            500                 505                 510         


Asp Glu Gln Trp Tyr Ser Phe Asn Asp Gln His Val Ser Arg Ile Thr 
        515                 520                 525             


Gln Glu Asp Ile Lys Lys Thr His Gly Gly Ser Ser Gly Ser Arg Gly 
    530                 535                 540                 


Tyr Tyr Ser Ser Ala Phe Ala Ser Ser Thr Asn Ala Tyr Met Leu Ile 
545                 550                 555                 560 


Tyr Arg Leu Lys Asp Pro Ala Arg Asn Ala Lys Phe Leu Glu Val Asp 
                565                 570                 575     


Glu Tyr Pro Glu His Ile Lys Asn Leu Val Gln Lys Glu Arg Glu Leu 
            580                 585                 590         


Glu Glu Gln Glu Lys Arg Gln Arg Glu Ile Glu Arg Asn Thr Cys Lys 
        595                 600                 605             


Ile Lys Leu Phe Cys Leu His Pro Thr Lys Gln Val Met Met Glu Asn 
    610                 615                 620                 


Lys Leu Glu Val His Lys Asp Lys Thr Leu Lys Glu Ala Val Glu Met 
625                 630                 635                 640 


Ala Tyr Lys Met Met Asp Leu Glu Glu Val Ile Pro Leu Asp Cys Cys 
                645                 650                 655     


Arg Leu Val Lys Tyr Asp Glu Phe His Asp Tyr Leu Glu Arg Ser Tyr 
            660                 665                 670         


Glu Gly Glu Glu Asp Thr Pro Met Gly Leu Leu Leu Gly Gly Val Lys 
        675                 680                 685             


Ser Thr Tyr Met Phe Asp Leu Leu Leu Glu Thr Arg Lys Pro Asp Gln 
    690                 695                 700                 


Val Phe Gln Ser Tyr Lys Pro Gly Glu Val Met Val Lys Val His Val 
705                 710                 715                 720 


Val Asp Leu Lys Ala Glu Ser Val Ala Ala Pro Ile Thr Val Arg Ala 
                725                 730                 735     


Tyr Leu Asn Gln Thr Val Thr Glu Phe Lys Gln Leu Ile Ser Lys Ala 
            740                 745                 750         


Ile His Leu Pro Ala Glu Thr Met Arg Ile Val Leu Glu Arg Cys Tyr 
        755                 760                 765             


Asn Asp Leu Arg Leu Leu Ser Val Ser Ser Lys Thr Leu Lys Ala Glu 
    770                 775                 780                 


Gly Phe Phe Arg Ser Asn Lys Val Phe Val Glu Ser Ser Glu Thr Leu 
785                 790                 795                 800 


Asp Tyr Gln Met Ala Phe Ala Asp Ser His Leu Trp Lys Leu Leu Asp 
                805                 810                 815     


Arg His Ala Asn Thr Ile Arg Leu Phe Val Leu Leu Pro Glu Gln Ser 
            820                 825                 830         


Pro Val Ser Tyr Ser Lys Arg Thr Ala Tyr Gln Lys Ala Gly Gly Asp 
        835                 840                 845             


Ser Gly Asn Val Asp Asp Asp Cys Glu Arg Val Lys Gly Pro Val Gly 
    850                 855                 860                 


Ser Leu Lys Ser Val Glu Ala Ile Leu Glu Glu Ser Thr Glu Lys Leu 
865                 870                 875                 880 


Lys Ser Leu Ser Leu Gln Gln Gln Gln Asp Gly Asp Asn Gly Asp Ser 
                885                 890                 895     


Ser Lys Ser Thr Glu Thr Ser Asp Phe Glu Asn Ile Glu Ser Pro Leu 
            900                 905                 910         


Asn Glu Arg Asp Ser Ser Ala Ser Val Asp Asn Arg Glu Leu Glu Gln 
        915                 920                 925             


His Ile Gln Thr Ser Asp Pro Glu Asn Phe Gln Ser Glu Glu Arg Ser 
    930                 935                 940                 


Asp Ser Asp Val Asn Asn Asp Arg Ser Thr Ser Ser Val Asp Ser Asp 
945                 950                 955                 960 


Ile Leu Ser Ser Ser His Ser Ser Asp Thr Leu Cys Asn Ala Asp Asn 
                965                 970                 975     


Ala Gln Ile Pro Leu Ala Asn Gly Leu Asp Ser His Ser Ile Thr Ser 
            980                 985                 990         


Ser Arg Arg Thr Lys Ala Asn Glu  Gly Lys Lys Glu Thr  Trp Asp Thr 
        995                 1000                 1005             


Ala Glu  Glu Asp Ser Gly Thr  Asp Ser Glu Tyr Asp  Glu Ser Gly 
    1010                 1015                 1020             


Lys Ser  Arg Gly Glu Met Gln  Tyr Met Tyr Phe Lys  Ala Glu Pro 
    1025                 1030                 1035             


Tyr Ala  Ala Asp Glu Gly Ser  Gly Glu Gly His Lys  Trp Leu Met 
    1040                 1045                 1050             


Val His  Val Asp Lys Arg Ile  Thr Leu Ala Ala Phe  Lys Gln His 
    1055                 1060                 1065             


Leu Glu  Pro Phe Val Gly Val  Leu Ser Ser His Phe  Lys Val Phe 
    1070                 1075                 1080             


Arg Val  Tyr Ala Ser Asn Gln  Glu Phe Glu Ser Val  Arg Leu Asn 
    1085                 1090                 1095             


Glu Thr  Leu Ser Ser Phe Ser  Asp Asp Asn Lys Ile  Thr Ile Arg 
    1100                 1105                 1110             


Leu Gly  Arg Ala Leu Lys Lys  Gly Glu Tyr Arg Val  Lys Val Tyr 
    1115                 1120                 1125             


Gln Leu  Leu Val Asn Glu Gln  Glu Pro Cys Lys Phe  Leu Leu Asp 
    1130                 1135                 1140             


Ala Val  Phe Ala Lys Gly Met  Thr Val Arg Gln Ser  Lys Glu Glu 
    1145                 1150                 1155             


Leu Ile  Pro Gln Leu Arg Glu  Gln Cys Gly Leu Glu  Leu Ser Ile 
    1160                 1165                 1170             


Asp Arg  Phe Arg Leu Arg Lys  Lys Thr Trp Lys Asn  Pro Gly Thr 
    1175                 1180                 1185             


Val Phe  Leu Asp Tyr His Ile  Tyr Glu Glu Asp Ile  Asn Ile Ser 
    1190                 1195                 1200             


Ser Asn  Trp Glu Val Phe Leu  Glu Val Leu Asp Gly  Val Glu Lys 
    1205                 1210                 1215             


Met Lys  Ser Met Ser Gln Leu  Ala Val Leu Ser Arg  Arg Trp Lys 
    1220                 1225                 1230             


Pro Ser  Glu Met Lys Leu Asp  Pro Phe Gln Glu Val  Val Leu Glu 
    1235                 1240                 1245             


Ser Ser  Ser Val Asp Glu Leu  Arg Glu Lys Leu Ser  Glu Ile Ser 
    1250                 1255                 1260             


Gly Ile  Pro Leu Asp Asp Ile  Glu Phe Ala Lys Gly  Arg Gly Thr 
    1265                 1270                 1275             


Phe Pro  Cys Asp Ile Ser Val  Leu Asp Ile His Gln  Asp Leu Asp 
    1280                 1285                 1290             


Trp Asn  Pro Lys Val Ser Thr  Leu Asn Val Trp Pro  Leu Tyr Ile 
    1295                 1300                 1305             


Cys Asp  Asp Gly Ala Val Ile  Phe Tyr Arg Asp Lys  Thr Glu Glu 
    1310                 1315                 1320             


Leu Met  Glu Leu Thr Asp Glu  Gln Arg Asn Glu Leu  Met Lys Lys 
    1325                 1330                 1335             


Glu Ser  Ser Arg Leu Gln Lys  Thr Gly His Arg Val  Thr Tyr Ser 
    1340                 1345                 1350             


Pro Arg  Lys Glu Lys Ala Leu  Lys Ile Tyr Leu Asp  Gly Ala Pro 
    1355                 1360                 1365             


Asn Lys  Asp Leu Thr Gln Asp  
    1370                 1375 


<210> 43
<211> 711
<212> PRT
<213> Homo sapiens

<400> 43
Met Ala Gln Val Arg Glu Thr Ser Leu Pro Ser Gly Ser Gly Val Arg 
1               5                   10                  15      


Trp Ile Ser Gly Gly Gly Gly Gly Ala Ser Pro Glu Glu Ala Val Glu 
            20                  25                  30          


Lys Ala Gly Lys Met Glu Glu Ala Ala Ala Gly Ala Thr Lys Ala Ser 
        35                  40                  45              


Ser Arg Arg Glu Ala Glu Glu Met Lys Leu Glu Pro Leu Gln Glu Arg 
    50                  55                  60                  


Glu Pro Ala Pro Glu Glu Asn Leu Thr Trp Ser Ser Ser Gly Gly Asp 
65                  70                  75                  80  


Glu Lys Val Leu Pro Ser Ile Pro Leu Arg Cys His Ser Ser Ser Ser 
                85                  90                  95      


Pro Val Cys Pro Arg Arg Lys Pro Arg Pro Arg Pro Gln Pro Arg Ala 
            100                 105                 110         


Arg Ser Arg Ser Gln Pro Gly Leu Ser Ala Pro Pro Pro Pro Pro Ala 
        115                 120                 125             


Arg Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Arg Pro 
    130                 135                 140                 


Arg Ala Trp Arg Gly Ser Arg Arg Arg Ser Arg Pro Gly Ser Arg Pro 
145                 150                 155                 160 


Gln Thr Arg Arg Ser Cys Ser Gly Asp Leu Asp Gly Ser Gly Asp Pro 
                165                 170                 175     


Gly Gly Leu Gly Asp Trp Leu Leu Glu Val Glu Phe Gly Gln Gly Pro 
            180                 185                 190         


Thr Gly Cys Ser His Val Glu Ser Phe Lys Val Gly Lys Asn Trp Gln 
        195                 200                 205             


Lys Asn Leu Arg Leu Ile Tyr Gln Arg Phe Val Trp Ser Gly Thr Pro 
    210                 215                 220                 


Glu Thr Arg Lys Arg Lys Ala Lys Ser Cys Ile Cys His Val Cys Ser 
225                 230                 235                 240 


Thr His Met Asn Arg Leu His Ser Cys Leu Ser Cys Val Phe Phe Gly 
                245                 250                 255     


Cys Phe Thr Glu Lys His Ile His Lys His Ala Glu Thr Lys Gln His 
            260                 265                 270         


His Leu Ala Val Asp Leu Tyr His Gly Val Ile Tyr Cys Phe Met Cys 
        275                 280                 285             


Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys Glu Thr 
    290                 295                 300                 


Lys Glu Lys Ile Leu Arg Leu Leu Thr Ser Thr Ser Thr Asp Val Ser 
305                 310                 315                 320 


His Gln Gln Phe Met Thr Ser Gly Phe Glu Asp Lys Gln Ser Thr Cys 
                325                 330                 335     


Glu Thr Lys Glu Gln Glu Pro Lys Leu Val Lys Pro Lys Lys Lys Arg 
            340                 345                 350         


Arg Lys Lys Ser Val Tyr Thr Val Gly Leu Arg Gly Leu Ile Asn Leu 
        355                 360                 365             


Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His Ile 
    370                 375                 380                 


Pro Leu Leu Lys Asp Phe Phe Leu Ser Asp Lys His Lys Cys Ile Met 
385                 390                 395                 400 


Thr Ser Pro Ser Leu Cys Leu Val Cys Glu Met Ser Ser Leu Phe His 
                405                 410                 415     


Ala Met Tyr Ser Gly Ser Arg Thr Pro His Ile Pro Tyr Lys Leu Leu 
            420                 425                 430         


His Leu Ile Trp Ile His Ala Glu His Leu Ala Gly Tyr Arg Gln Gln 
        435                 440                 445             


Asp Ala His Glu Phe Leu Ile Ala Ile Leu Asp Val Leu His Arg His 
    450                 455                 460                 


Ser Lys Asp Asp Ser Gly Gly Gln Glu Ala Asn Asn Pro Asn Cys Cys 
465                 470                 475                 480 


Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val 
                485                 490                 495     


Thr Cys Gln Ala Cys His Ser Val Ser Thr Thr Ile Asp Pro Cys Trp 
            500                 505                 510         


Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Ala Thr Phe Asp Ser Gln 
        515                 520                 525             


Asn Pro Glu Arg Ala Asp Ser Thr Val Ser Arg Asp Asp His Ile Pro 
    530                 535                 540                 


Gly Ile Pro Ser Leu Thr Asp Cys Leu Gln Trp Phe Thr Arg Pro Glu 
545                 550                 555                 560 


His Leu Gly Ser Ser Ala Lys Ile Lys Cys Asn Ser Cys Gln Ser Tyr 
                565                 570                 575     


Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro Ile Val Ala 
            580                 585                 590         


Cys Phe His Leu Lys Arg Phe Glu His Val Gly Lys Gln Arg Arg Lys 
        595                 600                 605             


Ile Asn Thr Phe Ile Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe 
    610                 615                 620                 


Leu Ala Ser Thr Lys Glu Ser Arg Met Lys Glu Gly Gln Pro Pro Thr 
625                 630                 635                 640 


Asp Cys Val Pro Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val Ile Asn 
                645                 650                 655     


His His Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile Arg Gln 
            660                 665                 670         


Gln Lys Asp Gln Trp Phe Ser Cys Asp Asp Ala Ile Ile Thr Lys Ala 
        675                 680                 685             


Thr Ile Glu Asp Leu Leu Tyr Ser Glu Gly Tyr Leu Leu Phe Tyr His 
    690                 695                 700                 


Lys Gln Gly Leu Glu Lys Asp 
705                 710     


<210> 44
<211> 1123
<212> PRT
<213> Homo sapiens

<400> 44
Met Pro Ile Val Asp Lys Leu Lys Glu Ala Leu Lys Pro Gly Arg Lys 
1               5                   10                  15      


Asp Ser Ala Asp Asp Gly Glu Leu Gly Lys Leu Leu Ala Ser Ser Ala 
            20                  25                  30          


Lys Lys Val Leu Leu Gln Lys Ile Glu Phe Glu Pro Ala Ser Lys Ser 
        35                  40                  45              


Phe Ser Tyr Gln Leu Glu Ala Leu Lys Ser Lys Tyr Val Leu Leu Asn 
    50                  55                  60                  


Pro Lys Thr Glu Gly Ala Ser Arg His Lys Ser Gly Asp Asp Pro Pro 
65                  70                  75                  80  


Ala Arg Arg Gln Gly Ser Glu His Thr Tyr Glu Ser Cys Gly Asp Gly 
                85                  90                  95      


Val Pro Ala Pro Gln Lys Val Leu Phe Pro Thr Glu Arg Leu Ser Leu 
            100                 105                 110         


Arg Trp Glu Arg Val Phe Arg Val Gly Ala Gly Leu His Asn Leu Gly 
        115                 120                 125             


Asn Thr Cys Phe Leu Asn Ala Thr Ile Gln Cys Leu Thr Tyr Thr Pro 
    130                 135                 140                 


Pro Leu Ala Asn Tyr Leu Leu Ser Lys Glu His Ala Arg Ser Cys His 
145                 150                 155                 160 


Gln Gly Ser Phe Cys Met Leu Cys Val Met Gln Asn His Ile Val Gln 
                165                 170                 175     


Ala Phe Ala Asn Ser Gly Asn Ala Ile Lys Pro Val Ser Phe Ile Arg 
            180                 185                 190         


Asp Leu Lys Lys Ile Ala Arg His Phe Arg Phe Gly Asn Gln Glu Asp 
        195                 200                 205             


Ala His Glu Phe Leu Arg Tyr Thr Ile Asp Ala Met Gln Lys Ala Cys 
    210                 215                 220                 


Leu Asn Gly Cys Ala Lys Leu Asp Arg Gln Thr Gln Ala Thr Thr Leu 
225                 230                 235                 240 


Val His Gln Ile Phe Gly Gly Tyr Leu Arg Ser Arg Val Lys Cys Ser 
                245                 250                 255     


Val Cys Lys Ser Val Ser Asp Thr Tyr Asp Pro Tyr Leu Asp Val Ala 
            260                 265                 270         


Leu Glu Ile Arg Gln Ala Ala Asn Ile Val Arg Ala Leu Glu Leu Phe 
        275                 280                 285             


Val Lys Ala Asp Val Leu Ser Gly Glu Asn Ala Tyr Met Cys Ala Lys 
    290                 295                 300                 


Cys Lys Lys Lys Val Pro Ala Ser Lys Arg Phe Thr Ile His Arg Thr 
305                 310                 315                 320 


Ser Asn Val Leu Thr Leu Ser Leu Lys Arg Phe Ala Asn Phe Ser Gly 
                325                 330                 335     


Gly Lys Ile Thr Lys Asp Val Gly Tyr Pro Glu Phe Leu Asn Ile Arg 
            340                 345                 350         


Pro Tyr Met Ser Gln Asn Asn Gly Asp Pro Val Met Tyr Gly Leu Tyr 
        355                 360                 365             


Ala Val Leu Val His Ser Gly Tyr Ser Cys His Ala Gly His Tyr Tyr 
    370                 375                 380                 


Cys Tyr Val Lys Ala Ser Asn Gly Gln Trp Tyr Gln Met Asn Asp Ser 
385                 390                 395                 400 


Leu Val His Ser Ser Asn Val Lys Val Val Leu Asn Gln Gln Ala Tyr 
                405                 410                 415     


Val Leu Phe Tyr Leu Arg Ile Pro Gly Ser Lys Lys Ser Pro Glu Gly 
            420                 425                 430         


Leu Ile Ser Arg Thr Gly Ser Ser Ser Leu Pro Gly Arg Pro Ser Val 
        435                 440                 445             


Ile Pro Asp His Ser Lys Lys Asn Ile Gly Asn Gly Ile Ile Ser Ser 
    450                 455                 460                 


Pro Leu Thr Gly Lys Arg Gln Asp Ser Gly Thr Met Lys Lys Pro His 
465                 470                 475                 480 


Thr Thr Glu Glu Ile Gly Val Pro Ile Ser Arg Asn Gly Ser Thr Leu 
                485                 490                 495     


Gly Leu Lys Ser Gln Asn Gly Cys Ile Pro Pro Lys Leu Pro Ser Gly 
            500                 505                 510         


Ser Pro Ser Pro Lys Leu Ser Gln Thr Pro Thr His Met Pro Thr Ile 
        515                 520                 525             


Leu Asp Asp Pro Gly Lys Lys Val Lys Lys Pro Ala Pro Pro Gln His 
    530                 535                 540                 


Phe Ser Pro Arg Thr Ala Gln Gly Leu Pro Gly Thr Ser Asn Ser Asn 
545                 550                 555                 560 


Ser Ser Arg Ser Gly Ser Gln Arg Gln Gly Ser Trp Asp Ser Arg Asp 
                565                 570                 575     


Val Val Leu Ser Thr Ser Pro Lys Leu Leu Ala Thr Ala Thr Ala Asn 
            580                 585                 590         


Gly His Gly Leu Lys Gly Asn Asp Glu Ser Ala Gly Leu Asp Arg Arg 
        595                 600                 605             


Gly Ser Ser Ser Ser Ser Pro Glu His Ser Ala Ser Ser Asp Ser Thr 
    610                 615                 620                 


Lys Ala Pro Gln Thr Pro Arg Ser Gly Ala Ala His Leu Cys Asp Ser 
625                 630                 635                 640 


Gln Glu Thr Asn Cys Ser Thr Ala Gly His Ser Lys Thr Pro Pro Ser 
                645                 650                 655     


Gly Ala Asp Ser Lys Thr Val Lys Leu Lys Ser Pro Val Leu Ser Asn 
            660                 665                 670         


Thr Thr Thr Glu Pro Ala Ser Thr Met Ser Pro Pro Pro Ala Lys Lys 
        675                 680                 685             


Leu Ala Leu Ser Ala Lys Lys Ala Ser Thr Leu Trp Arg Ala Thr Gly 
    690                 695                 700                 


Asn Asp Leu Arg Pro Pro Pro Pro Ser Pro Ser Ser Asp Leu Thr His 
705                 710                 715                 720 


Pro Met Lys Thr Ser His Pro Val Val Ala Ser Thr Trp Pro Val His 
                725                 730                 735     


Arg Ala Arg Ala Val Ser Pro Ala Pro Gln Ser Ser Ser Arg Leu Gln 
            740                 745                 750         


Pro Pro Phe Ser Pro His Pro Thr Leu Leu Ser Ser Thr Pro Lys Pro 
        755                 760                 765             


Pro Gly Thr Ser Glu Pro Arg Ser Cys Ser Ser Ile Ser Thr Ala Leu 
    770                 775                 780                 


Pro Gln Val Asn Glu Asp Leu Val Ser Leu Pro His Gln Leu Pro Glu 
785                 790                 795                 800 


Ala Ser Glu Pro Pro Gln Ser Pro Ser Glu Lys Arg Lys Lys Thr Phe 
                805                 810                 815     


Val Gly Glu Pro Gln Arg Leu Gly Ser Glu Thr Arg Leu Pro Gln His 
            820                 825                 830         


Ile Arg Glu Ala Thr Ala Ala Pro His Gly Lys Arg Lys Arg Lys Lys 
        835                 840                 845             


Lys Lys Arg Pro Glu Asp Thr Ala Ala Ser Ala Leu Gln Glu Gly Gln 
    850                 855                 860                 


Thr Gln Arg Gln Pro Gly Ser Pro Met Tyr Arg Arg Glu Gly Gln Ala 
865                 870                 875                 880 


Gln Leu Pro Ala Val Arg Arg Gln Glu Asp Gly Thr Gln Pro Gln Val 
                885                 890                 895     


Asn Gly Gln Gln Val Gly Cys Val Thr Asp Gly His His Ala Ser Ser 
            900                 905                 910         


Arg Lys Arg Arg Arg Lys Gly Ala Glu Gly Leu Gly Glu Glu Gly Gly 
        915                 920                 925             


Leu His Gln Asp Pro Leu Arg His Ser Cys Ser Pro Met Gly Asp Gly 
    930                 935                 940                 


Asp Pro Glu Ala Met Glu Glu Ser Pro Arg Lys Lys Lys Lys Lys Lys 
945                 950                 955                 960 


Arg Lys Gln Glu Thr Gln Arg Ala Val Glu Glu Asp Gly His Leu Lys 
                965                 970                 975     


Cys Pro Arg Ser Ala Lys Pro Gln Asp Ala Val Val Pro Glu Ser Ser 
            980                 985                 990         


Ser Cys Ala Pro Ser Ala Asn Gly  Trp Cys Pro Gly Asp  Arg Met Gly 
        995                 1000                 1005             


Leu Ser  Gln Ala Pro Pro Val  Ser Trp Asn Gly Glu  Arg Glu Ser 
    1010                 1015                 1020             


Asp Val  Val Gln Glu Leu Leu  Lys Tyr Ser Ser Asp  Lys Ala Tyr 
    1025                 1030                 1035             


Gly Arg  Lys Val Leu Thr Trp  Asp Gly Lys Met Ser  Ala Val Ser 
    1040                 1045                 1050             


Gln Asp  Ala Ile Glu Asp Ser  Arg Gln Ala Arg Thr  Glu Thr Val 
    1055                 1060                 1065             


Val Asp  Asp Trp Asp Glu Glu  Phe Asp Arg Gly Lys  Glu Lys Lys 
    1070                 1075                 1080             


Ile Lys  Lys Phe Lys Arg Glu  Lys Arg Arg Asn Phe  Asn Ala Phe 
    1085                 1090                 1095             


Gln Lys  Leu Gln Thr Arg Arg  Asn Phe Trp Ser Val  Thr His Pro 
    1100                 1105                 1110             


Ala Lys  Ala Ala Ser Leu Ser  Tyr Arg Arg 
    1115                 1120             


<210> 45
<211> 712
<212> PRT
<213> Homo sapiens

<400> 45
Met Leu Ala Met Asp Thr Cys Lys His Val Gly Gln Leu Gln Leu Ala 
1               5                   10                  15      


Gln Asp His Ser Ser Leu Asn Pro Gln Lys Trp His Cys Val Asp Cys 
            20                  25                  30          


Asn Thr Thr Glu Ser Ile Trp Ala Cys Leu Ser Cys Ser His Val Ala 
        35                  40                  45              


Cys Gly Arg Tyr Ile Glu Glu His Ala Leu Lys His Phe Gln Glu Ser 
    50                  55                  60                  


Ser His Pro Val Ala Leu Glu Val Asn Glu Met Tyr Val Phe Cys Tyr 
65                  70                  75                  80  


Leu Cys Asp Asp Tyr Val Leu Asn Asp Asn Thr Thr Gly Asp Leu Lys 
                85                  90                  95      


Leu Leu Arg Arg Thr Leu Ser Ala Ile Lys Ser Gln Asn Tyr His Cys 
            100                 105                 110         


Thr Thr Arg Ser Gly Arg Phe Leu Arg Ser Met Gly Thr Gly Asp Asp 
        115                 120                 125             


Ser Tyr Phe Leu His Asp Gly Ala Gln Ser Leu Leu Gln Ser Glu Asp 
    130                 135                 140                 


Gln Leu Tyr Thr Ala Leu Trp His Arg Arg Arg Ile Leu Met Gly Lys 
145                 150                 155                 160 


Ile Phe Arg Thr Trp Phe Glu Gln Ser Pro Ile Gly Arg Lys Lys Gln 
                165                 170                 175     


Glu Glu Pro Phe Gln Glu Lys Ile Val Val Lys Arg Glu Val Lys Lys 
            180                 185                 190         


Arg Arg Gln Glu Leu Glu Tyr Gln Val Lys Ala Glu Leu Glu Ser Met 
        195                 200                 205             


Pro Pro Arg Lys Ser Leu Arg Leu Gln Gly Leu Ala Gln Ser Thr Ile 
    210                 215                 220                 


Ile Glu Ile Val Ser Val Gln Val Pro Ala Gln Thr Pro Ala Ser Pro 
225                 230                 235                 240 


Ala Lys Asp Lys Val Leu Ser Thr Ser Glu Asn Glu Ile Ser Gln Lys 
                245                 250                 255     


Val Ser Asp Ser Ser Val Lys Arg Arg Pro Ile Val Thr Pro Gly Val 
            260                 265                 270         


Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Val Leu 
        275                 280                 285             


Gln Val Leu Ser His Leu Leu Ile Phe Arg Gln Cys Phe Leu Lys Leu 
    290                 295                 300                 


Asp Leu Asn Gln Trp Leu Ala Met Thr Ala Ser Glu Lys Thr Arg Ser 
305                 310                 315                 320 


Cys Lys His Pro Pro Val Thr Asp Thr Val Val Tyr Gln Met Asn Glu 
                325                 330                 335     


Cys Gln Glu Lys Asp Thr Gly Phe Val Cys Ser Arg Gln Ser Ser Leu 
            340                 345                 350         


Ser Ser Gly Leu Ser Gly Gly Ala Ser Lys Gly Arg Lys Met Glu Leu 
        355                 360                 365             


Ile Gln Pro Lys Glu Pro Thr Ser Gln Tyr Ile Ser Leu Cys His Glu 
    370                 375                 380                 


Leu His Thr Leu Phe Gln Val Met Trp Ser Gly Lys Trp Ala Leu Val 
385                 390                 395                 400 


Ser Pro Phe Ala Met Leu His Ser Val Trp Arg Leu Ile Pro Ala Phe 
                405                 410                 415     


Arg Gly Tyr Ala Gln Gln Asp Ala Gln Glu Phe Leu Cys Glu Leu Leu 
            420                 425                 430         


Asp Lys Ile Gln Arg Glu Leu Glu Thr Thr Gly Thr Ser Leu Pro Ala 
        435                 440                 445             


Leu Ile Pro Thr Ser Gln Arg Lys Leu Ile Lys Gln Val Leu Asn Val 
    450                 455                 460                 


Val Asn Asn Ile Phe His Gly Gln Leu Leu Ser Gln Val Thr Cys Leu 
465                 470                 475                 480 


Ala Cys Asp Asn Lys Ser Asn Thr Ile Glu Pro Phe Trp Asp Leu Ser 
                485                 490                 495     


Leu Glu Phe Pro Glu Arg Tyr Gln Cys Ser Gly Lys Asp Ile Ala Ser 
            500                 505                 510         


Gln Pro Cys Leu Val Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu 
        515                 520                 525             


Ala Leu Glu Gly Lys Ile Tyr Val Cys Asp Gln Cys Asn Ser Lys Arg 
    530                 535                 540                 


Arg Arg Phe Ser Ser Lys Pro Val Val Leu Thr Glu Ala Gln Lys Gln 
545                 550                 555                 560 


Leu Met Ile Cys His Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg 
                565                 570                 575     


Phe Arg Trp Ser Gly Arg Asn Asn Arg Glu Lys Ile Gly Val His Val 
            580                 585                 590         


Gly Phe Glu Glu Ile Leu Asn Met Glu Pro Tyr Cys Cys Arg Glu Thr 
        595                 600                 605             


Leu Lys Ser Leu Arg Pro Glu Cys Phe Ile Tyr Asp Leu Ser Ala Val 
    610                 615                 620                 


Val Met His His Gly Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr 
625                 630                 635                 640 


Cys Tyr Asn Ser Glu Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys 
                645                 650                 655     


Leu Ser Met Cys Thr Met Asp Glu Val Cys Lys Ala Gln Ala Tyr Ile 
            660                 665                 670         


Leu Phe Tyr Thr Gln Arg Val Thr Glu Asn Gly His Ser Lys Leu Leu 
        675                 680                 685             


Pro Pro Glu Leu Leu Leu Gly Ser Gln His Pro Asn Glu Asp Ala Asp 
    690                 695                 700                 


Thr Ser Ser Asn Glu Ile Leu Ser 
705                 710         


<210> 46
<211> 1118
<212> PRT
<213> Homo sapiens

<400> 46
Met Pro Ala Val Ala Ser Val Pro Lys Glu Leu Tyr Leu Ser Ser Ser 
1               5                   10                  15      


Leu Lys Asp Leu Asn Lys Lys Thr Glu Val Lys Pro Glu Lys Ile Ser 
            20                  25                  30          


Thr Lys Ser Tyr Val His Ser Ala Leu Lys Ile Phe Lys Thr Ala Glu 
        35                  40                  45              


Glu Cys Arg Leu Asp Arg Asp Glu Glu Arg Ala Tyr Val Leu Tyr Met 
    50                  55                  60                  


Lys Tyr Val Thr Val Tyr Asn Leu Ile Lys Lys Arg Pro Asp Phe Lys 
65                  70                  75                  80  


Gln Gln Gln Asp Tyr Phe His Ser Ile Leu Gly Pro Gly Asn Ile Lys 
                85                  90                  95      


Lys Ala Val Glu Glu Ala Glu Arg Leu Ser Glu Ser Leu Lys Leu Arg 
            100                 105                 110         


Tyr Glu Glu Ala Glu Val Arg Lys Lys Leu Glu Glu Lys Asp Arg Gln 
        115                 120                 125             


Glu Glu Ala Gln Arg Leu Gln Gln Lys Arg Gln Glu Thr Gly Arg Glu 
    130                 135                 140                 


Asp Gly Gly Thr Leu Ala Lys Gly Ser Leu Glu Asn Val Leu Asp Ser 
145                 150                 155                 160 


Lys Asp Lys Thr Gln Lys Ser Asn Gly Glu Lys Asn Glu Lys Cys Glu 
                165                 170                 175     


Thr Lys Glu Lys Gly Ala Ile Thr Ala Lys Glu Leu Tyr Thr Met Met 
            180                 185                 190         


Thr Asp Lys Asn Ile Ser Leu Ile Ile Met Asp Ala Arg Arg Met Gln 
        195                 200                 205             


Asp Tyr Gln Asp Ser Cys Ile Leu His Ser Leu Ser Val Pro Glu Glu 
    210                 215                 220                 


Ala Ile Ser Pro Gly Val Thr Ala Ser Trp Ile Glu Ala His Leu Pro 
225                 230                 235                 240 


Asp Asp Ser Lys Asp Thr Trp Lys Lys Arg Gly Asn Val Glu Tyr Val 
                245                 250                 255     


Val Leu Leu Asp Trp Phe Ser Ser Ala Lys Asp Leu Gln Ile Gly Thr 
            260                 265                 270         


Thr Leu Arg Ser Leu Lys Asp Ala Leu Phe Lys Trp Glu Ser Lys Thr 
        275                 280                 285             


Val Leu Arg Asn Glu Pro Leu Val Leu Glu Gly Gly Tyr Glu Asn Trp 
    290                 295                 300                 


Leu Leu Cys Tyr Pro Gln Tyr Thr Thr Asn Ala Lys Val Thr Pro Pro 
305                 310                 315                 320 


Pro Arg Arg Gln Asn Glu Glu Val Ser Ile Ser Leu Asp Phe Thr Tyr 
                325                 330                 335     


Pro Ser Leu Glu Glu Ser Ile Pro Ser Lys Pro Ala Ala Gln Thr Pro 
            340                 345                 350         


Pro Ala Ser Ile Glu Val Asp Glu Asn Ile Glu Leu Ile Ser Gly Gln 
        355                 360                 365             


Asn Glu Arg Met Gly Pro Leu Asn Ile Ser Thr Pro Val Glu Pro Val 
    370                 375                 380                 


Ala Ala Ser Lys Ser Asp Val Ser Pro Ile Ile Gln Pro Val Pro Ser 
385                 390                 395                 400 


Ile Lys Asn Val Pro Gln Ile Asp Arg Thr Lys Lys Pro Ala Val Lys 
                405                 410                 415     


Leu Pro Glu Glu His Arg Ile Lys Ser Glu Ser Thr Asn His Glu Gln 
            420                 425                 430         


Gln Ser Pro Gln Ser Gly Lys Val Ile Pro Asp Arg Ser Thr Lys Pro 
        435                 440                 445             


Val Val Phe Ser Pro Thr Leu Met Leu Thr Asp Glu Glu Lys Ala Arg 
    450                 455                 460                 


Ile His Ala Glu Thr Ala Leu Leu Met Glu Lys Asn Lys Gln Glu Lys 
465                 470                 475                 480 


Glu Leu Arg Glu Arg Gln Gln Glu Glu Gln Lys Glu Lys Leu Arg Lys 
                485                 490                 495     


Glu Glu Gln Glu Gln Lys Ala Lys Lys Lys Gln Glu Ala Glu Glu Asn 
            500                 505                 510         


Glu Ile Thr Glu Lys Gln Gln Lys Ala Lys Glu Glu Met Glu Lys Lys 
        515                 520                 525             


Glu Ser Glu Gln Ala Lys Lys Glu Asp Lys Glu Thr Ser Ala Lys Arg 
    530                 535                 540                 


Gly Lys Glu Ile Thr Gly Val Lys Arg Gln Ser Lys Ser Glu His Glu 
545                 550                 555                 560 


Thr Ser Asp Ala Lys Lys Ser Val Glu Asp Arg Gly Lys Arg Cys Pro 
                565                 570                 575     


Thr Pro Glu Ile Gln Lys Lys Ser Thr Gly Asp Val Pro His Thr Ser 
            580                 585                 590         


Val Thr Gly Asp Ser Gly Ser Gly Lys Pro Phe Lys Ile Lys Gly Gln 
        595                 600                 605             


Pro Glu Ser Gly Ile Leu Arg Thr Gly Thr Phe Arg Glu Asp Thr Asp 
    610                 615                 620                 


Asp Thr Glu Arg Asn Lys Ala Gln Arg Glu Pro Leu Thr Arg Ala Arg 
625                 630                 635                 640 


Ser Glu Glu Met Gly Arg Ile Val Pro Gly Leu Pro Ser Gly Trp Ala 
                645                 650                 655     


Lys Phe Leu Asp Pro Ile Thr Gly Thr Phe Arg Tyr Tyr His Ser Pro 
            660                 665                 670         


Thr Asn Thr Val His Met Tyr Pro Pro Glu Met Ala Pro Ser Ser Ala 
        675                 680                 685             


Pro Pro Ser Thr Pro Pro Thr His Lys Ala Lys Pro Gln Ile Pro Ala 
    690                 695                 700                 


Glu Arg Asp Arg Glu Pro Ser Lys Leu Lys Arg Ser Tyr Ser Ser Pro 
705                 710                 715                 720 


Asp Ile Thr Gln Ala Ile Gln Glu Glu Glu Lys Arg Lys Pro Thr Val 
                725                 730                 735     


Thr Pro Thr Val Asn Arg Glu Asn Lys Pro Thr Cys Tyr Pro Lys Ala 
            740                 745                 750         


Glu Ile Ser Arg Leu Ser Ala Ser Gln Ile Arg Asn Leu Asn Pro Val 
        755                 760                 765             


Phe Gly Gly Ser Gly Pro Ala Leu Thr Gly Leu Arg Asn Leu Gly Asn 
    770                 775                 780                 


Thr Cys Tyr Met Asn Ser Ile Leu Gln Cys Leu Cys Asn Ala Pro His 
785                 790                 795                 800 


Leu Ala Asp Tyr Phe Asn Arg Asn Cys Tyr Gln Asp Asp Ile Asn Arg 
                805                 810                 815     


Ser Asn Leu Leu Gly His Lys Gly Glu Val Ala Glu Glu Phe Gly Ile 
            820                 825                 830         


Ile Met Lys Ala Leu Trp Thr Gly Gln Tyr Arg Tyr Ile Ser Pro Lys 
        835                 840                 845             


Asp Phe Lys Ile Thr Ile Gly Lys Ile Asn Asp Gln Phe Ala Gly Tyr 
    850                 855                 860                 


Ser Gln Gln Asp Ser Gln Glu Leu Leu Leu Phe Leu Met Asp Gly Leu 
865                 870                 875                 880 


His Glu Asp Leu Asn Lys Ala Asp Asn Arg Lys Arg Tyr Lys Glu Glu 
                885                 890                 895     


Asn Asn Asp His Leu Asp Asp Phe Lys Ala Ala Glu His Ala Trp Gln 
            900                 905                 910         


Lys His Lys Gln Leu Asn Glu Ser Ile Ile Val Ala Leu Phe Gln Gly 
        915                 920                 925             


Gln Phe Lys Ser Thr Val Gln Cys Leu Thr Cys His Lys Lys Ser Arg 
    930                 935                 940                 


Thr Phe Glu Ala Phe Met Tyr Leu Ser Leu Pro Leu Ala Ser Thr Ser 
945                 950                 955                 960 


Lys Cys Thr Leu Gln Asp Cys Leu Arg Leu Phe Ser Lys Glu Glu Lys 
                965                 970                 975     


Leu Thr Asp Asn Asn Arg Phe Tyr Cys Ser His Cys Arg Ala Arg Arg 
            980                 985                 990         


Asp Ser Leu Lys Lys Ile Glu Ile  Trp Lys Leu Pro Pro  Val Leu Leu 
        995                 1000                 1005             


Val His  Leu Lys Arg Phe Ser  Tyr Asp Gly Arg Trp  Lys Gln Lys 
    1010                 1015                 1020             


Leu Gln  Thr Ser Val Asp Phe  Pro Leu Glu Asn Leu  Asp Leu Ser 
    1025                 1030                 1035             


Gln Tyr  Val Ile Gly Pro Lys  Asn Asn Leu Lys Lys  Tyr Asn Leu 
    1040                 1045                 1050             


Phe Ser  Val Ser Asn His Tyr  Gly Gly Leu Asp Gly  Gly His Tyr 
    1055                 1060                 1065             


Thr Ala  Tyr Cys Lys Asn Ala  Ala Arg Gln Arg Trp  Phe Lys Phe 
    1070                 1075                 1080             


Asp Asp  His Glu Val Ser Asp  Ile Ser Val Ser Ser  Val Lys Ser 
    1085                 1090                 1095             


Ser Ala  Ala Tyr Ile Leu Phe  Tyr Thr Ser Leu Gly  Pro Arg Val 
    1100                 1105                 1110             


Thr Asp  Val Ala Thr 
    1115             


<210> 47
<211> 979
<212> PRT
<213> Homo sapiens

<400> 47
Met Ser Pro Leu Lys Ile His Gly Pro Ile Arg Ile Arg Ser Met Gln 
1               5                   10                  15      


Thr Gly Ile Thr Lys Trp Lys Glu Gly Ser Phe Glu Ile Val Glu Lys 
            20                  25                  30          


Glu Asn Lys Val Ser Leu Val Val His Tyr Asn Thr Gly Gly Ile Pro 
        35                  40                  45              


Arg Ile Phe Gln Leu Ser His Asn Ile Lys Asn Val Val Leu Arg Pro 
    50                  55                  60                  


Ser Gly Ala Lys Gln Ser Arg Leu Met Leu Thr Leu Gln Asp Asn Ser 
65                  70                  75                  80  


Phe Leu Ser Ile Asp Lys Val Pro Ser Lys Asp Ala Glu Glu Met Arg 
                85                  90                  95      


Leu Phe Leu Asp Ala Val His Gln Asn Arg Leu Pro Ala Ala Met Lys 
            100                 105                 110         


Pro Ser Gln Gly Ser Gly Ser Phe Gly Ala Ile Leu Gly Ser Arg Thr 
        115                 120                 125             


Ser Gln Lys Glu Thr Ser Arg Gln Leu Ser Tyr Ser Asp Asn Gln Ala 
    130                 135                 140                 


Ser Ala Lys Arg Gly Ser Leu Glu Thr Lys Asp Asp Ile Pro Phe Arg 
145                 150                 155                 160 


Lys Val Leu Gly Asn Pro Gly Arg Gly Ser Ile Lys Thr Val Ala Gly 
                165                 170                 175     


Ser Gly Ile Ala Arg Thr Ile Pro Ser Leu Thr Ser Thr Ser Thr Pro 
            180                 185                 190         


Leu Arg Ser Gly Leu Leu Glu Asn Arg Thr Glu Lys Arg Lys Arg Met 
        195                 200                 205             


Ile Ser Thr Gly Ser Glu Leu Asn Glu Asp Tyr Pro Lys Glu Asn Asp 
    210                 215                 220                 


Ser Ser Ser Asn Asn Lys Ala Met Thr Asp Pro Ser Arg Lys Tyr Leu 
225                 230                 235                 240 


Thr Ser Ser Arg Glu Lys Gln Leu Ser Leu Lys Gln Ser Glu Glu Asn 
                245                 250                 255     


Arg Thr Ser Gly Leu Leu Pro Leu Gln Ser Ser Ser Phe Tyr Gly Ser 
            260                 265                 270         


Arg Ala Gly Ser Lys Glu His Ser Ser Gly Gly Thr Asn Leu Asp Arg 
        275                 280                 285             


Thr Asn Val Ser Ser Gln Thr Pro Ser Ala Lys Arg Ser Leu Gly Phe 
    290                 295                 300                 


Leu Pro Gln Pro Val Pro Leu Ser Val Lys Lys Leu Arg Cys Asn Gln 
305                 310                 315                 320 


Asp Tyr Thr Gly Trp Asn Lys Pro Arg Val Pro Leu Ser Ser His Gln 
                325                 330                 335     


Gln Gln Gln Leu Gln Gly Phe Ser Asn Leu Gly Asn Thr Cys Tyr Met 
            340                 345                 350         


Asn Ala Ile Leu Gln Ser Leu Phe Ser Leu Gln Ser Phe Ala Asn Asp 
        355                 360                 365             


Leu Leu Lys Gln Gly Ile Pro Trp Lys Lys Ile Pro Leu Asn Ala Leu 
    370                 375                 380                 


Ile Arg Arg Phe Ala His Leu Leu Val Lys Lys Asp Ile Cys Asn Ser 
385                 390                 395                 400 


Glu Thr Lys Lys Asp Leu Leu Lys Lys Val Lys Asn Ala Ile Ser Ala 
                405                 410                 415     


Thr Ala Glu Arg Phe Ser Gly Tyr Met Gln Asn Asp Ala His Glu Phe 
            420                 425                 430         


Leu Ser Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn 
        435                 440                 445             


Lys Thr Trp Lys Thr Glu Pro Val Ser Gly Glu Glu Asn Ser Pro Asp 
    450                 455                 460                 


Ile Ser Ala Thr Arg Ala Tyr Thr Cys Pro Val Ile Thr Asn Leu Glu 
465                 470                 475                 480 


Phe Glu Val Gln His Ser Ile Ile Cys Lys Ala Cys Gly Glu Ile Ile 
                485                 490                 495     


Pro Lys Arg Glu Gln Phe Asn Asp Leu Ser Ile Asp Leu Pro Arg Arg 
            500                 505                 510         


Lys Lys Pro Leu Pro Pro Arg Ser Ile Gln Asp Ser Leu Asp Leu Phe 
        515                 520                 525             


Phe Arg Ala Glu Glu Leu Glu Tyr Ser Cys Glu Lys Cys Gly Gly Lys 
    530                 535                 540                 


Cys Ala Leu Val Arg His Lys Phe Asn Arg Leu Pro Arg Val Leu Ile 
545                 550                 555                 560 


Leu His Leu Lys Arg Tyr Ser Phe Asn Val Ala Leu Ser Leu Asn Asn 
                565                 570                 575     


Lys Ile Gly Gln Gln Val Ile Ile Pro Arg Tyr Leu Thr Leu Ser Ser 
            580                 585                 590         


His Cys Thr Glu Asn Thr Lys Pro Pro Phe Thr Leu Gly Trp Ser Ala 
        595                 600                 605             


His Met Ala Ile Ser Arg Pro Leu Lys Ala Ser Gln Met Val Asn Ser 
    610                 615                 620                 


Cys Ile Thr Ser Pro Ser Thr Pro Ser Lys Lys Phe Thr Phe Lys Ser 
625                 630                 635                 640 


Lys Ser Ser Leu Ala Leu Cys Leu Asp Ser Asp Ser Glu Asp Glu Leu 
                645                 650                 655     


Lys Arg Ser Val Ala Leu Ser Gln Arg Leu Cys Glu Met Leu Gly Asn 
            660                 665                 670         


Glu Gln Gln Gln Glu Asp Leu Glu Lys Asp Ser Lys Leu Cys Pro Ile 
        675                 680                 685             


Glu Pro Asp Lys Ser Glu Leu Glu Asn Ser Gly Phe Asp Arg Met Ser 
    690                 695                 700                 


Glu Glu Glu Leu Leu Ala Ala Val Leu Glu Ile Ser Lys Arg Asp Ala 
705                 710                 715                 720 


Ser Pro Ser Leu Ser His Glu Asp Asp Asp Lys Pro Thr Ser Ser Pro 
                725                 730                 735     


Asp Thr Gly Phe Ala Glu Asp Asp Ile Gln Glu Met Pro Glu Asn Pro 
            740                 745                 750         


Asp Thr Met Glu Thr Glu Lys Pro Lys Thr Ile Thr Glu Leu Asp Pro 
        755                 760                 765             


Ala Ser Phe Thr Glu Ile Thr Lys Asp Cys Asp Glu Asn Lys Glu Asn 
    770                 775                 780                 


Lys Thr Pro Glu Gly Ser Gln Gly Glu Val Asp Trp Leu Gln Gln Tyr 
785                 790                 795                 800 


Asp Met Glu Arg Glu Arg Glu Glu Gln Glu Leu Gln Gln Ala Leu Ala 
                805                 810                 815     


Gln Ser Leu Gln Glu Gln Glu Ala Trp Glu Gln Lys Glu Asp Asp Asp 
            820                 825                 830         


Leu Lys Arg Ala Thr Glu Leu Ser Leu Gln Glu Phe Asn Asn Ser Phe 
        835                 840                 845             


Val Asp Ala Leu Gly Ser Asp Glu Asp Ser Gly Asn Glu Asp Val Phe 
    850                 855                 860                 


Asp Met Glu Tyr Thr Glu Ala Glu Ala Glu Glu Leu Lys Arg Asn Ala 
865                 870                 875                 880 


Glu Thr Gly Asn Leu Pro His Ser Tyr Arg Leu Ile Ser Val Val Ser 
                885                 890                 895     


His Ile Gly Ser Thr Ser Ser Ser Gly His Tyr Ile Ser Asp Val Tyr 
            900                 905                 910         


Asp Ile Lys Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Glu Val Ser 
        915                 920                 925             


Lys Ile Gln Glu Ala Ala Val Gln Ser Asp Arg Asp Arg Ser Gly Tyr 
    930                 935                 940                 


Ile Phe Phe Tyr Met His Lys Glu Ile Phe Asp Glu Leu Leu Glu Thr 
945                 950                 955                 960 


Glu Lys Asn Ser Gln Ser Leu Ser Thr Glu Val Gly Lys Thr Thr Arg 
                965                 970                 975     


Gln Ala Leu 
            


<210> 48
<211> 530
<212> PRT
<213> Homo sapiens

<400> 48
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Leu Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Val Pro Glu Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His Pro Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp Arg Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 49
<211> 530
<212> PRT
<213> Homo sapiens

<400> 49
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ser Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Gly Lys Val Glu Gly Thr Leu Pro Pro Asn Ala Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ala Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 50
<211> 1684
<212> PRT
<213> Homo sapiens

<400> 50
Met Ser Trp Lys Arg Asn Tyr Phe Ser Gly Gly Arg Gly Ser Val Gln 
1               5                   10                  15      


Gly Met Phe Ala Pro Arg Ser Ser Thr Ser Ile Ala Pro Ser Lys Gly 
            20                  25                  30          


Leu Ser Asn Glu Pro Gly Gln Asn Ser Cys Phe Leu Asn Ser Ala Leu 
        35                  40                  45              


Gln Val Leu Trp His Leu Asp Ile Phe Arg Arg Ser Phe Arg Gln Leu 
    50                  55                  60                  


Thr Thr His Lys Cys Met Gly Asp Ser Cys Ile Phe Cys Ala Leu Lys 
65                  70                  75                  80  


Gly Ile Phe Asn Gln Phe Gln Cys Ser Ser Glu Lys Val Leu Pro Ser 
                85                  90                  95      


Asp Thr Leu Arg Ser Ala Leu Ala Lys Thr Phe Gln Asp Glu Gln Arg 
            100                 105                 110         


Phe Gln Leu Gly Ile Met Asp Asp Ala Ala Glu Cys Phe Glu Asn Leu 
        115                 120                 125             


Leu Met Arg Ile His Phe His Ile Ala Asp Glu Thr Lys Glu Asp Ile 
    130                 135                 140                 


Cys Thr Ala Gln His Cys Ile Ser His Gln Lys Phe Ala Met Thr Leu 
145                 150                 155                 160 


Phe Glu Gln Cys Val Cys Thr Ser Cys Gly Ala Thr Ser Asp Pro Leu 
                165                 170                 175     


Pro Phe Ile Gln Met Val His Tyr Ile Ser Thr Thr Ser Leu Cys Asn 
            180                 185                 190         


Gln Ala Ile Cys Met Leu Glu Arg Arg Glu Lys Pro Ser Pro Ser Met 
        195                 200                 205             


Phe Gly Glu Leu Leu Gln Asn Ala Ser Thr Met Gly Asp Leu Arg Asn 
    210                 215                 220                 


Cys Pro Ser Asn Cys Gly Glu Arg Ile Arg Ile Arg Arg Val Leu Met 
225                 230                 235                 240 


Asn Ala Pro Gln Ile Ile Thr Ile Gly Leu Val Trp Asp Ser Asp His 
                245                 250                 255     


Ser Asp Leu Ala Glu Asp Val Ile His Ser Leu Gly Thr Cys Leu Lys 
            260                 265                 270         


Leu Gly Asp Leu Phe Phe Arg Val Thr Asp Asp Arg Ala Lys Gln Ser 
        275                 280                 285             


Glu Leu Tyr Leu Val Gly Met Ile Cys Tyr Tyr Gly Lys His Tyr Ser 
    290                 295                 300                 


Thr Phe Phe Phe Gln Thr Lys Ile Arg Lys Trp Met Tyr Phe Asp Asp 
305                 310                 315                 320 


Ala His Val Lys Glu Ile Gly Pro Lys Trp Lys Asp Val Val Thr Lys 
                325                 330                 335     


Cys Ile Lys Gly His Tyr Gln Pro Leu Leu Leu Leu Tyr Ala Asp Pro 
            340                 345                 350         


Gln Gly Thr Pro Val Ser Thr Gln Asp Leu Pro Pro Gln Ala Glu Phe 
        355                 360                 365             


Gln Ser Tyr Ser Arg Thr Cys Tyr Asp Ser Glu Asp Ser Gly Arg Glu 
    370                 375                 380                 


Pro Ser Ile Ser Ser Asp Thr Arg Thr Asp Ser Ser Thr Glu Ser Tyr 
385                 390                 395                 400 


Pro Tyr Lys His Ser His His Glu Ser Val Val Ser His Phe Ser Ser 
                405                 410                 415     


Asp Ser Gln Gly Thr Val Ile Tyr Asn Val Glu Asn Asp Ser Met Ser 
            420                 425                 430         


Gln Ser Ser Arg Asp Thr Gly His Leu Thr Asp Ser Glu Cys Asn Gln 
        435                 440                 445             


Lys His Thr Ser Lys Lys Gly Ser Leu Ile Glu Arg Lys Arg Ser Ser 
    450                 455                 460                 


Gly Arg Val Arg Arg Lys Gly Asp Glu Pro Gln Ala Ser Gly Tyr His 
465                 470                 475                 480 


Ser Glu Gly Glu Thr Leu Lys Glu Lys Gln Ala Pro Arg Asn Ala Ser 
                485                 490                 495     


Lys Pro Ser Ser Ser Thr Asn Arg Leu Arg Asp Phe Lys Glu Thr Val 
            500                 505                 510         


Ser Asn Met Ile His Asn Arg Pro Ser Leu Ala Ser Gln Thr Asn Val 
        515                 520                 525             


Gly Ser His Cys Arg Gly Arg Gly Gly Asp Gln Pro Asp Lys Lys Pro 
    530                 535                 540                 


Pro Arg Thr Leu Pro Leu His Ser Arg Asp Trp Glu Ile Glu Ser Thr 
545                 550                 555                 560 


Ser Ser Glu Ser Lys Ser Ser Ser Ser Ser Lys Tyr Arg Pro Thr Trp 
                565                 570                 575     


Arg Pro Lys Arg Glu Ser Leu Asn Ile Asp Ser Ile Phe Ser Lys Asp 
            580                 585                 590         


Lys Arg Lys His Cys Gly Tyr Thr Gln Leu Ser Pro Phe Ser Glu Asp 
        595                 600                 605             


Ser Ala Lys Glu Phe Ile Pro Asp Glu Pro Ser Lys Pro Pro Ser Tyr 
    610                 615                 620                 


Asp Ile Lys Phe Gly Gly Pro Ser Pro Gln Tyr Lys Arg Trp Gly Pro 
625                 630                 635                 640 


Ala Arg Pro Gly Ser His Leu Leu Glu Gln His Pro Arg Leu Ile Gln 
                645                 650                 655     


Arg Met Glu Ser Gly Tyr Glu Ser Ser Glu Arg Asn Ser Ser Ser Pro 
            660                 665                 670         


Val Ser Leu Asp Ala Ala Leu Pro Glu Ser Ser Asn Val Tyr Arg Asp 
        675                 680                 685             


Pro Ser Ala Lys Arg Ser Ala Gly Leu Val Pro Ser Trp Arg His Ile 
    690                 695                 700                 


Pro Lys Ser His Ser Ser Ser Ile Leu Glu Val Asp Ser Thr Ala Ser 
705                 710                 715                 720 


Met Gly Gly Trp Thr Lys Ser Gln Pro Phe Ser Gly Glu Glu Ile Ser 
                725                 730                 735     


Ser Lys Ser Glu Leu Asp Glu Leu Gln Glu Glu Val Ala Arg Arg Ala 
            740                 745                 750         


Gln Glu Gln Glu Leu Arg Arg Lys Arg Glu Lys Glu Leu Glu Ala Ala 
        755                 760                 765             


Lys Gly Phe Asn Pro His Pro Ser Arg Phe Met Asp Leu Asp Glu Leu 
    770                 775                 780                 


Gln Asn Gln Gly Arg Ser Asp Gly Phe Glu Arg Ser Leu Gln Glu Ala 
785                 790                 795                 800 


Glu Ser Val Phe Glu Glu Ser Leu His Leu Glu Gln Lys Gly Asp Cys 
                805                 810                 815     


Ala Ala Ala Leu Ala Leu Cys Asn Glu Ala Ile Ser Lys Leu Arg Leu 
            820                 825                 830         


Ala Leu His Gly Ala Ser Cys Ser Thr His Ser Arg Ala Leu Val Asp 
        835                 840                 845             


Lys Lys Leu Gln Ile Ser Ile Arg Lys Ala Arg Ser Leu Gln Asp Arg 
    850                 855                 860                 


Met Gln Gln Gln Gln Ser Pro Gln Gln Pro Ser Gln Pro Ser Ala Cys 
865                 870                 875                 880 


Leu Pro Thr Gln Ala Gly Thr Leu Ser Gln Pro Thr Ser Glu Gln Pro 
                885                 890                 895     


Ile Pro Leu Gln Val Leu Leu Ser Gln Glu Ala Gln Leu Glu Ser Gly 
            900                 905                 910         


Met Asp Thr Glu Phe Gly Ala Ser Ser Phe Phe His Ser Pro Ala Ser 
        915                 920                 925             


Cys His Glu Ser His Ser Ser Leu Ser Pro Glu Ser Ser Ala Pro Gln 
    930                 935                 940                 


His Ser Ser Pro Ser Arg Ser Ala Leu Lys Leu Leu Thr Ser Val Glu 
945                 950                 955                 960 


Val Asp Asn Ile Glu Pro Ser Ala Phe His Arg Gln Gly Leu Pro Lys 
                965                 970                 975     


Ala Pro Gly Trp Thr Glu Lys Asn Ser His His Ser Trp Glu Pro Leu 
            980                 985                 990         


Asp Ala Pro Glu Gly Lys Leu Gln  Gly Ser Arg Cys Asp  Asn Ser Ser 
        995                 1000                 1005             


Cys Ser  Lys Leu Pro Pro Gln  Glu Gly Arg Gly Ile  Ala Gln Glu 
    1010                 1015                 1020             


Gln Leu  Phe Gln Glu Lys Lys  Asp Pro Ala Asn Pro  Ser Pro Val 
    1025                 1030                 1035             


Met Pro  Gly Ile Ala Thr Ser  Glu Arg Gly Asp Glu  His Ser Leu 
    1040                 1045                 1050             


Gly Cys  Ser Pro Ser Asn Ser  Ser Ala Gln Pro Ser  Leu Pro Leu 
    1055                 1060                 1065             


Tyr Arg  Thr Cys His Pro Ile  Met Pro Val Ala Ser  Ser Phe Val 
    1070                 1075                 1080             


Leu His  Cys Pro Asp Pro Val  Gln Lys Thr Asn Gln  Cys Leu Gln 
    1085                 1090                 1095             


Gly Gln  Ser Leu Lys Thr Ser  Leu Thr Leu Lys Val  Asp Arg Gly 
    1100                 1105                 1110             


Ser Glu  Glu Thr Tyr Arg Pro  Glu Phe Pro Ser Thr  Lys Gly Leu 
    1115                 1120                 1125             


Val Arg  Ser Leu Ala Glu Gln  Phe Gln Arg Met Gln  Gly Val Ser 
    1130                 1135                 1140             


Met Arg  Asp Ser Thr Gly Phe  Lys Asp Arg Ser Leu  Ser Gly Ser 
    1145                 1150                 1155             


Leu Arg  Lys Asn Ser Ser Pro  Ser Asp Ser Lys Pro  Pro Phe Ser 
    1160                 1165                 1170             


Gln Gly  Gln Glu Lys Gly His  Trp Pro Trp Ala Lys  Gln Gln Ser 
    1175                 1180                 1185             


Ser Leu  Glu Gly Gly Asp Arg  Pro Leu Ser Trp Glu  Glu Ser Thr 
    1190                 1195                 1200             


Glu His  Ser Ser Leu Ala Leu  Asn Ser Gly Leu Pro  Asn Gly Glu 
    1205                 1210                 1215             


Thr Ser  Ser Gly Gly Gln Pro  Arg Leu Ala Glu Pro  Asp Ile Tyr 
    1220                 1225                 1230             


Gln Glu  Lys Leu Ser Gln Val  Arg Asp Val Arg Ser  Lys Asp Leu 
    1235                 1240                 1245             


Gly Ser  Ser Thr Asp Leu Gly  Thr Ser Leu Pro Leu  Asp Ser Trp 
    1250                 1255                 1260             


Val Asn  Ile Thr Arg Phe Cys  Asp Ser Gln Leu Lys  His Gly Ala 
    1265                 1270                 1275             


Pro Arg  Pro Gly Met Lys Ser  Ser Pro His Asp Ser  His Thr Cys 
    1280                 1285                 1290             


Val Thr  Tyr Pro Glu Arg Asn  His Ile Leu Leu His  Pro His Trp 
    1295                 1300                 1305             


Asn Gln  Asp Thr Glu Gln Glu  Thr Ser Glu Leu Glu  Ser Leu Tyr 
    1310                 1315                 1320             


Gln Ala  Ser Leu Gln Ala Ser  Gln Ala Gly Cys Ser  Gly Trp Gly 
    1325                 1330                 1335             


Gln Gln  Asp Thr Ala Trp His  Pro Leu Ser Gln Thr  Gly Ser Ala 
    1340                 1345                 1350             


Asp Gly  Met Gly Arg Arg Leu  His Ser Ala His Asp  Pro Gly Leu 
    1355                 1360                 1365             


Ser Lys  Thr Ser Thr Ala Glu  Met Glu His Gly Leu  His Glu Ala 
    1370                 1375                 1380             


Arg Thr  Val Arg Thr Ser Gln  Ala Thr Pro Cys Arg  Gly Leu Ser 
    1385                 1390                 1395             


Arg Glu  Cys Gly Glu Asp Glu  Gln Tyr Ser Ala Glu  Asn Leu Arg 
    1400                 1405                 1410             


Arg Ile  Ser Arg Ser Leu Ser  Gly Thr Val Val Ser  Glu Arg Glu 
    1415                 1420                 1425             


Glu Ala  Pro Val Ser Ser His  Ser Phe Asp Ser Ser  Asn Val Arg 
    1430                 1435                 1440             


Lys Pro  Leu Glu Thr Gly His  Arg Cys Ser Ser Ser  Ser Ser Leu 
    1445                 1450                 1455             


Pro Val  Ile His Asp Pro Ser  Val Phe Leu Leu Gly  Pro Gln Leu 
    1460                 1465                 1470             


Tyr Leu  Pro Gln Pro Gln Phe  Leu Ser Pro Asp Val  Leu Met Pro 
    1475                 1480                 1485             


Thr Met  Ala Gly Glu Pro Asn  Arg Leu Pro Gly Thr  Ser Arg Ser 
    1490                 1495                 1500             


Val Gln  Gln Phe Leu Ala Met  Cys Asp Arg Gly Glu  Thr Ser Gln 
    1505                 1510                 1515             


Gly Ala  Lys Tyr Thr Gly Arg  Thr Leu Asn Tyr Gln  Ser Leu Pro 
    1520                 1525                 1530             


His Arg  Ser Arg Thr Asp Asn  Ser Trp Ala Pro Trp  Ser Glu Thr 
    1535                 1540                 1545             


Asn Gln  His Ile Gly Thr Arg  Phe Leu Thr Thr Pro  Gly Cys Asn 
    1550                 1555                 1560             


Pro Gln  Leu Thr Tyr Thr Ala  Thr Leu Pro Glu Arg  Ser Lys Gly 
    1565                 1570                 1575             


Leu Gln  Val Pro His Thr Gln  Ser Trp Ser Asp Leu  Phe His Ser 
    1580                 1585                 1590             


Pro Ser  His Pro Pro Ile Val  His Pro Val Tyr Pro  Pro Ser Ser 
    1595                 1600                 1605             


Ser Leu  His Val Pro Leu Arg  Ser Ala Trp Asn Ser  Asp Pro Val 
    1610                 1615                 1620             


Pro Gly  Ser Arg Thr Pro Gly  Pro Arg Arg Val Asp  Met Pro Pro 
    1625                 1630                 1635             


Asp Asp  Asp Trp Arg Gln Ser  Ser Tyr Ala Ser His  Ser Gly His 
    1640                 1645                 1650             


Arg Arg  Thr Val Gly Glu Gly  Phe Leu Phe Val Leu  Ser Asp Ala 
    1655                 1660                 1665             


Pro Arg  Arg Glu Gln Ile Arg  Ala Arg Val Leu Gln  His Ser Gln 
    1670                 1675                 1680             


Trp 
    


<210> 51
<211> 565
<212> PRT
<213> Homo sapiens

<400> 51
Met Ser Gly Arg Ser Lys Arg Glu Ser Arg Gly Ser Thr Arg Gly Lys 
1               5                   10                  15      


Arg Glu Ser Glu Ser Arg Gly Ser Ser Gly Arg Val Lys Arg Glu Arg 
            20                  25                  30          


Asp Arg Glu Arg Glu Pro Glu Ala Ala Ser Ser Arg Gly Ser Pro Val 
        35                  40                  45              


Arg Val Lys Arg Glu Phe Glu Pro Ala Ser Ala Arg Glu Ala Pro Ala 
    50                  55                  60                  


Ser Val Val Pro Phe Val Arg Val Lys Arg Glu Arg Glu Val Asp Glu 
65                  70                  75                  80  


Asp Ser Glu Pro Glu Arg Glu Val Arg Ala Lys Asn Gly Arg Val Asp 
                85                  90                  95      


Ser Glu Asp Arg Arg Ser Arg His Cys Pro Tyr Leu Asp Thr Ile Asn 
            100                 105                 110         


Arg Ser Val Leu Asp Phe Asp Phe Glu Lys Leu Cys Ser Ile Ser Leu 
        115                 120                 125             


Ser His Ile Asn Ala Tyr Ala Cys Leu Val Cys Gly Lys Tyr Phe Gln 
    130                 135                 140                 


Gly Arg Gly Leu Lys Ser His Ala Tyr Ile His Ser Val Gln Phe Ser 
145                 150                 155                 160 


His His Val Phe Leu Asn Leu His Thr Leu Lys Phe Tyr Cys Leu Pro 
                165                 170                 175     


Asp Asn Tyr Glu Ile Ile Asp Ser Ser Leu Glu Asp Ile Thr Tyr Val 
            180                 185                 190         


Leu Lys Pro Thr Phe Thr Lys Gln Gln Ile Ala Asn Leu Asp Lys Gln 
        195                 200                 205             


Ala Lys Leu Ser Arg Ala Tyr Asp Gly Thr Thr Tyr Leu Pro Gly Ile 
    210                 215                 220                 


Val Gly Leu Asn Asn Ile Lys Ala Asn Asp Tyr Ala Asn Ala Val Leu 
225                 230                 235                 240 


Gln Ala Leu Ser Asn Val Pro Pro Leu Arg Asn Tyr Phe Leu Glu Glu 
                245                 250                 255     


Asp Asn Tyr Lys Asn Ile Lys Arg Pro Pro Gly Asp Ile Met Phe Leu 
            260                 265                 270         


Leu Val Gln Arg Phe Gly Glu Leu Met Arg Lys Leu Trp Asn Pro Arg 
        275                 280                 285             


Asn Phe Lys Ala His Val Ser Pro His Glu Met Leu Gln Ala Val Val 
    290                 295                 300                 


Leu Cys Ser Lys Lys Thr Phe Gln Ile Thr Lys Gln Gly Asp Gly Val 
305                 310                 315                 320 


Asp Phe Leu Ser Trp Phe Leu Asn Ala Leu His Ser Ala Leu Gly Gly 
                325                 330                 335     


Thr Lys Lys Lys Lys Lys Thr Ile Val Thr Asp Val Phe Gln Gly Ser 
            340                 345                 350         


Met Arg Ile Phe Thr Lys Lys Leu Pro His Pro Asp Leu Pro Ala Glu 
        355                 360                 365             


Glu Lys Glu Gln Leu Leu His Asn Asp Glu Tyr Gln Glu Thr Met Val 
    370                 375                 380                 


Glu Ser Thr Phe Met Tyr Leu Thr Leu Asp Leu Pro Thr Ala Pro Leu 
385                 390                 395                 400 


Tyr Lys Asp Glu Lys Glu Gln Leu Ile Ile Pro Gln Val Pro Leu Phe 
                405                 410                 415     


Asn Ile Leu Ala Lys Phe Asn Gly Ile Thr Glu Lys Glu Tyr Lys Thr 
            420                 425                 430         


Tyr Lys Glu Asn Phe Leu Lys Arg Phe Gln Leu Thr Lys Leu Pro Pro 
        435                 440                 445             


Tyr Leu Ile Phe Cys Ile Lys Arg Phe Thr Lys Asn Asn Phe Phe Val 
    450                 455                 460                 


Glu Lys Asn Pro Thr Ile Val Asn Phe Pro Ile Thr Asn Val Asp Leu 
465                 470                 475                 480 


Arg Glu Tyr Leu Ser Glu Glu Val Gln Ala Val His Lys Asn Thr Thr 
                485                 490                 495     


Tyr Asp Leu Ile Ala Asn Ile Val His Asp Gly Lys Pro Ser Glu Gly 
            500                 505                 510         


Ser Tyr Arg Ile His Val Leu His His Gly Thr Gly Lys Trp Tyr Glu 
        515                 520                 525             


Leu Gln Asp Leu Gln Val Thr Asp Ile Leu Pro Gln Met Ile Thr Leu 
    530                 535                 540                 


Ser Glu Ala Tyr Ile Gln Ile Trp Lys Arg Arg Asp Asn Asp Glu Thr 
545                 550                 555                 560 


Asn Gln Gln Gly Ala 
                565 


<210> 52
<211> 1018
<212> PRT
<213> Homo sapiens

<400> 52
Met Asp Lys Ile Leu Glu Ala Val Val Thr Ser Ser Tyr Pro Val Ser 
1               5                   10                  15      


Val Lys Gln Gly Leu Val Arg Arg Val Leu Glu Ala Ala Arg Gln Pro 
            20                  25                  30          


Leu Glu Arg Glu Gln Cys Leu Ala Leu Leu Ala Leu Gly Ala Arg Leu 
        35                  40                  45              


Tyr Val Gly Gly Ala Glu Glu Leu Pro Arg Arg Val Gly Cys Gln Leu 
    50                  55                  60                  


Leu His Val Ala Gly Arg His His Pro Asp Val Phe Ala Glu Phe Phe 
65                  70                  75                  80  


Ser Ala Arg Arg Val Leu Arg Leu Leu Gln Gly Gly Ala Gly Pro Pro 
                85                  90                  95      


Gly Pro Arg Ala Leu Ala Cys Val Gln Leu Gly Leu Gln Leu Leu Pro 
            100                 105                 110         


Glu Gly Pro Ala Ala Asp Glu Val Phe Ala Leu Leu Arg Arg Glu Val 
        115                 120                 125             


Leu Arg Thr Val Cys Glu Arg Pro Gly Pro Ala Ala Cys Ala Gln Val 
    130                 135                 140                 


Ala Arg Leu Leu Ala Arg His Pro Arg Cys Val Pro Asp Gly Pro His 
145                 150                 155                 160 


Arg Leu Leu Phe Cys Gln Gln Leu Val Arg Cys Leu Gly Arg Phe Arg 
                165                 170                 175     


Cys Pro Ala Glu Gly Glu Glu Gly Ala Val Glu Phe Leu Glu Gln Ala 
            180                 185                 190         


Gln Gln Val Ser Gly Leu Leu Ala Gln Leu Trp Arg Ala Gln Pro Ala 
        195                 200                 205             


Ala Ile Leu Pro Cys Leu Lys Glu Leu Phe Ala Val Ile Ser Cys Ala 
    210                 215                 220                 


Glu Glu Glu Pro Pro Ser Ser Ala Leu Ala Ser Val Val Gln His Leu 
225                 230                 235                 240 


Pro Leu Glu Leu Met Asp Gly Val Val Arg Asn Leu Ser Asn Asp Asp 
                245                 250                 255     


Ser Val Thr Asp Ser Gln Met Leu Thr Ala Ile Ser Arg Met Ile Asp 
            260                 265                 270         


Trp Val Ser Trp Pro Leu Gly Lys Asn Ile Asp Lys Trp Ile Ile Ala 
        275                 280                 285             


Leu Leu Lys Gly Leu Ala Ala Val Lys Lys Phe Ser Ile Leu Ile Glu 
    290                 295                 300                 


Val Ser Leu Thr Lys Ile Glu Lys Val Phe Ser Lys Leu Leu Tyr Pro 
305                 310                 315                 320 


Ile Val Arg Gly Ala Ala Leu Ser Val Leu Lys Tyr Met Leu Leu Thr 
                325                 330                 335     


Phe Gln His Ser His Glu Ala Phe His Leu Leu Leu Pro His Ile Pro 
            340                 345                 350         


Pro Met Val Ala Ser Leu Val Lys Glu Asp Ser Asn Ser Gly Thr Ser 
        355                 360                 365             


Cys Leu Glu Gln Leu Ala Glu Leu Val His Cys Met Val Phe Arg Phe 
    370                 375                 380                 


Pro Gly Phe Pro Asp Leu Tyr Glu Pro Val Met Glu Ala Ile Lys Asp 
385                 390                 395                 400 


Leu His Val Pro Asn Glu Asp Arg Ile Lys Gln Leu Leu Gly Gln Asp 
                405                 410                 415     


Ala Trp Thr Ser Gln Lys Ser Glu Leu Ala Gly Phe Tyr Pro Arg Leu 
            420                 425                 430         


Met Ala Lys Ser Asp Thr Gly Lys Ile Gly Leu Ile Asn Leu Gly Asn 
        435                 440                 445             


Thr Cys Tyr Val Asn Ser Ile Leu Gln Ala Leu Phe Met Ala Ser Asp 
    450                 455                 460                 


Phe Arg His Cys Val Leu Arg Leu Thr Glu Asn Asn Ser Gln Pro Leu 
465                 470                 475                 480 


Met Thr Lys Leu Gln Trp Leu Phe Gly Phe Leu Glu His Ser Gln Arg 
                485                 490                 495     


Pro Ala Ile Ser Pro Glu Asn Phe Leu Ser Ala Ser Trp Thr Pro Trp 
            500                 505                 510         


Phe Ser Pro Gly Thr Gln Gln Asp Cys Ser Glu Tyr Leu Lys Tyr Leu 
        515                 520                 525             


Leu Asp Arg Leu His Glu Glu Glu Lys Thr Gly Thr Arg Ile Cys Gln 
    530                 535                 540                 


Lys Leu Lys Gln Ser Ser Ser Pro Ser Pro Pro Glu Glu Pro Pro Ala 
545                 550                 555                 560 


Pro Ser Ser Thr Ser Val Glu Lys Met Phe Gly Gly Lys Ile Val Thr 
                565                 570                 575     


Arg Ile Cys Cys Leu Cys Cys Leu Asn Val Ser Ser Arg Glu Glu Ala 
            580                 585                 590         


Phe Thr Asp Leu Ser Leu Ala Phe Pro Pro Pro Glu Arg Cys Arg Arg 
        595                 600                 605             


Arg Arg Leu Gly Ser Val Met Arg Pro Thr Glu Asp Ile Thr Ala Arg 
    610                 615                 620                 


Glu Leu Pro Pro Pro Thr Ser Ala Gln Gly Pro Gly Arg Val Gly Pro 
625                 630                 635                 640 


Arg Arg Gln Arg Lys His Cys Ile Thr Glu Asp Thr Pro Pro Thr Ser 
                645                 650                 655     


Leu Tyr Ile Glu Gly Leu Asp Ser Lys Glu Ala Gly Gly Gln Ser Ser 
            660                 665                 670         


Gln Glu Glu Arg Ile Glu Arg Glu Glu Glu Gly Lys Glu Glu Arg Thr 
        675                 680                 685             


Glu Lys Glu Glu Val Gly Glu Glu Glu Glu Ser Thr Arg Gly Glu Gly 
    690                 695                 700                 


Glu Arg Glu Lys Glu Glu Glu Val Glu Glu Glu Glu Glu Lys Val Glu 
705                 710                 715                 720 


Lys Glu Thr Glu Lys Glu Ala Glu Gln Glu Lys Glu Glu Asp Ser Leu 
                725                 730                 735     


Gly Ala Gly Thr His Pro Asp Ala Ala Ile Pro Ser Gly Glu Arg Thr 
            740                 745                 750         


Cys Gly Ser Glu Gly Ser Arg Ser Val Leu Asp Leu Val Asn Tyr Phe 
        755                 760                 765             


Leu Ser Pro Glu Lys Leu Thr Ala Glu Asn Arg Tyr Tyr Cys Glu Ser 
    770                 775                 780                 


Cys Ala Ser Leu Gln Asp Ala Glu Lys Val Val Glu Leu Ser Gln Gly 
785                 790                 795                 800 


Pro Cys Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Phe Asp Leu Arg 
                805                 810                 815     


Thr Met Arg Arg Arg Lys Ile Leu Asp Asp Val Ser Ile Pro Leu Leu 
            820                 825                 830         


Leu Arg Leu Pro Leu Ala Gly Gly Arg Gly Gln Ala Tyr Asp Leu Cys 
        835                 840                 845             


Ser Val Val Val His Ser Gly Val Ser Ser Glu Ser Gly His Tyr Tyr 
    850                 855                 860                 


Cys Tyr Ala Arg Glu Gly Ala Ala Arg Pro Ala Ala Ser Leu Gly Thr 
865                 870                 875                 880 


Ala Asp Arg Pro Glu Pro Glu Asn Gln Trp Tyr Leu Phe Asn Asp Thr 
                885                 890                 895     


Arg Val Ser Phe Ser Ser Phe Glu Ser Val Ser Asn Val Thr Ser Phe 
            900                 905                 910         


Phe Pro Lys Asp Thr Ala Tyr Val Leu Phe Tyr Arg Gln Arg Pro Arg 
        915                 920                 925             


Glu Gly Pro Glu Ala Glu Leu Gly Ser Ser Arg Val Arg Thr Glu Pro 
    930                 935                 940                 


Thr Leu His Lys Asp Leu Met Glu Ala Ile Ser Lys Asp Asn Ile Leu 
945                 950                 955                 960 


Tyr Leu Gln Glu Gln Glu Lys Glu Ala Arg Ser Arg Ala Ala Tyr Ile 
                965                 970                 975     


Ser Ala Leu Pro Thr Ser Pro His Trp Gly Arg Gly Phe Asp Glu Asp 
            980                 985                 990         


Lys Asp Glu Asp Glu Gly Ser Pro  Gly Gly Cys Asn Pro  Ala Gly Gly 
        995                 1000                 1005             


Asn Gly  Gly Asp Phe His Arg  Leu Val Phe 
    1010                 1015             


<210> 53
<211> 981
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala Glu Gly Gly Ala Ala Asp Leu Asp Thr Gln Arg Ser Asp Ile 
1               5                   10                  15      


Ala Thr Leu Leu Lys Thr Ser Leu Arg Lys Gly Asp Thr Trp Tyr Leu 
            20                  25                  30          


Val Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr Val Gly Phe Asp 
        35                  40                  45              


Ser Trp Asp Lys Tyr Gln Met Gly Asp Gln Asn Val Tyr Pro Gly Pro 
    50                  55                  60                  


Ile Asp Asn Ser Gly Leu Leu Lys Asp Gly Asp Ala Gln Ser Leu Lys 
65                  70                  75                  80  


Glu His Leu Ile Asp Glu Leu Asp Tyr Ile Leu Leu Pro Thr Glu Gly 
                85                  90                  95      


Trp Asn Lys Leu Val Ser Trp Tyr Thr Leu Met Glu Gly Gln Glu Pro 
            100                 105                 110         


Ile Ala Arg Lys Val Val Glu Gln Gly Met Phe Val Lys His Cys Lys 
        115                 120                 125             


Val Glu Val Tyr Leu Thr Glu Leu Lys Leu Cys Glu Asn Gly Asn Met 
    130                 135                 140                 


Asn Asn Val Val Thr Arg Arg Phe Ser Lys Ala Asp Thr Ile Asp Thr 
145                 150                 155                 160 


Ile Glu Lys Glu Ile Arg Lys Ile Phe Ser Ile Pro Asp Glu Lys Glu 
                165                 170                 175     


Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Phe Glu Pro Leu Asn 
            180                 185                 190         


Lys Pro Asp Ser Thr Ile Gln Asp Ala Gly Leu Tyr Gln Gly Gln Val 
        195                 200                 205             


Leu Val Ile Glu Gln Lys Asn Glu Asp Gly Thr Trp Pro Arg Gly Pro 
    210                 215                 220                 


Ser Thr Pro Lys Ser Pro Gly Ala Ser Asn Phe Ser Thr Leu Pro Lys 
225                 230                 235                 240 


Ile Ser Pro Ser Ser Leu Ser Asn Asn Tyr Asn Asn Met Asn Asn Arg 
                245                 250                 255     


Asn Val Lys Asn Ser Asn Tyr Cys Leu Pro Ser Tyr Thr Ala Tyr Lys 
            260                 265                 270         


Asn Tyr Asp Tyr Ser Glu Pro Gly Arg Asn Asn Glu Gln Pro Gly Leu 
        275                 280                 285             


Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Ile 
    290                 295                 300                 


Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu Tyr Phe Leu Asn Asp 
305                 310                 315                 320 


Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro Leu Gly Met Arg Gly 
                325                 330                 335     


Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly 
            340                 345                 350         


Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys Thr Gln Val Gly Arg 
        355                 360                 365             


Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln Asp Cys Gln Glu Leu 
    370                 375                 380                 


Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Arg 
385                 390                 395                 400 


Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp Gly Arg Pro Asp Lys 
                405                 410                 415     


Val Val Ala Glu Glu Ala Trp Glu Asn His Leu Lys Arg Asn Asp Ser 
            420                 425                 430         


Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys 
        435                 440                 445             


Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu 
    450                 455                 460                 


Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr Leu Glu Val Tyr Leu 
465                 470                 475                 480 


Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln Tyr Lys Val Val Val 
                485                 490                 495     


Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr Ala Leu Ser Ala Leu 
            500                 505                 510         


Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr Asp Ile Tyr Asn His 
        515                 520                 525             


Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn Leu Ser Ser Ile Met 
    530                 535                 540                 


Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn Ile Asn Arg Thr Glu 
545                 550                 555                 560 


Asp Thr Glu His Val Ile Ile Pro Val Cys Leu Arg Glu Lys Phe Arg 
                565                 570                 575     


His Ser Ser Tyr Thr His His Thr Gly Ser Ser Leu Phe Gly Gln Pro 
            580                 585                 590         


Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu Asp Lys Leu Tyr Asn 
        595                 600                 605             


Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys Ile Ser Thr Glu Thr 
    610                 615                 620                 


Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys Asp Gln Asn Ile Asn 
625                 630                 635                 640 


Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly Ser Pro Ser Glu Met 
                645                 650                 655     


Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln Asp Gln Glu Leu Pro 
            660                 665                 670         


Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser Val Gly Gly Asp Asn 
        675                 680                 685             


Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr Cys Lys Gly Gln Leu 
    690                 695                 700                 


Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln Phe Asn Asn Leu Gly 
705                 710                 715                 720 


Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr Arg His Ile Arg Phe 
                725                 730                 735     


Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser Phe Leu Ala Leu Asp 
            740                 745                 750         


Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp Glu Asn Ala Ala Glu 
        755                 760                 765             


Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys Pro Pro Lys Lys Pro 
    770                 775                 780                 


Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe Thr Thr Lys Glu Lys 
785                 790                 795                 800 


Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn Cys Lys Glu His Gln 
                805                 810                 815     


Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu Pro Pro Val Leu Val 
            820                 825                 830         


Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr Met Arg Asp Lys Leu 
        835                 840                 845             


Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu Asp Met Ser Glu Phe 
    850                 855                 860                 


Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr Asn Leu Ile Ala Val 
865                 870                 875                 880 


Ser Asn His Tyr Gly Gly Met Gly Gly Gly His Tyr Thr Ala Phe Ala 
                885                 890                 895     


Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe Asp Asp Ser Ser Val 
            900                 905                 910         


Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys Ala Ala Tyr Val Leu 
        915                 920                 925             


Phe Tyr Gln Arg Gln Asp Thr Phe Ser Gly Thr Gly Phe Phe Pro Leu 
    930                 935                 940                 


Asp Arg Glu Thr Lys Gly Ala Ser Ala Ala Thr Gly Ile Pro Leu Glu 
945                 950                 955                 960 


Ser Asp Glu Asp Ser Asn Asp Asn Asp Asn Asp Ile Glu Asn Glu Asn 
                965                 970                 975     


Cys Met His Thr Asn 
            980     


<210> 54
<211> 922
<212> PRT
<213> Homo sapiens

<400> 54
Met Ile Ser Leu Lys Val Cys Gly Phe Ile Gln Ile Trp Ser Gln Lys 
1               5                   10                  15      


Thr Gly Met Thr Lys Leu Lys Glu Ala Leu Ile Glu Thr Val Gln Arg 
            20                  25                  30          


Gln Lys Glu Ile Lys Leu Val Val Thr Phe Lys Ser Gly Lys Phe Ile 
        35                  40                  45              


Arg Ile Phe Gln Leu Ser Asn Asn Ile Arg Ser Val Val Leu Arg His 
    50                  55                  60                  


Cys Lys Lys Arg Gln Ser His Leu Arg Leu Thr Leu Lys Asn Asn Val 
65                  70                  75                  80  


Phe Leu Phe Ile Asp Lys Leu Ser Tyr Arg Asp Ala Lys Gln Leu Asn 
                85                  90                  95      


Met Phe Leu Asp Ile Ile His Gln Asn Lys Ser Gln Gln Pro Met Lys 
            100                 105                 110         


Ser Asp Asp Asp Trp Ser Val Phe Glu Ser Arg Asn Met Leu Lys Glu 
        115                 120                 125             


Ile Asp Lys Thr Ser Phe Tyr Ser Ile Cys Asn Lys Pro Ser Tyr Gln 
    130                 135                 140                 


Lys Met Pro Leu Phe Met Ser Lys Ser Pro Thr His Val Lys Lys Gly 
145                 150                 155                 160 


Ile Leu Glu Asn Gln Gly Gly Lys Gly Gln Asn Thr Leu Ser Ser Asp 
                165                 170                 175     


Val Gln Thr Asn Glu Asp Ile Leu Lys Glu Asp Asn Pro Val Pro Asn 
            180                 185                 190         


Lys Lys Tyr Lys Thr Asp Ser Leu Lys Tyr Ile Gln Ser Asn Arg Lys 
        195                 200                 205             


Asn Pro Ser Ser Leu Glu Asp Leu Glu Lys Asp Arg Asp Leu Lys Leu 
    210                 215                 220                 


Gly Pro Ser Phe Asn Thr Asn Cys Asn Gly Asn Pro Asn Leu Asp Glu 
225                 230                 235                 240 


Thr Val Leu Ala Thr Gln Thr Leu Asn Ala Lys Asn Gly Leu Thr Ser 
                245                 250                 255     


Pro Leu Glu Pro Glu His Ser Gln Gly Asp Pro Arg Cys Asn Lys Ala 
            260                 265                 270         


Gln Val Pro Leu Asp Ser His Ser Gln Gln Leu Gln Gln Gly Phe Pro 
        275                 280                 285             


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ala Val Leu Gln Ser Leu Phe 
    290                 295                 300                 


Ala Ile Pro Ser Phe Ala Asp Asp Leu Leu Thr Gln Gly Val Pro Trp 
305                 310                 315                 320 


Glu Tyr Ile Pro Phe Glu Ala Leu Ile Met Thr Leu Thr Gln Leu Leu 
                325                 330                 335     


Ala Leu Lys Asp Phe Cys Ser Thr Lys Ile Lys Arg Glu Leu Leu Gly 
            340                 345                 350         


Asn Val Lys Lys Val Ile Ser Ala Val Ala Glu Ile Phe Ser Gly Asn 
        355                 360                 365             


Met Gln Asn Asp Ala His Glu Phe Leu Gly Gln Cys Leu Asp Gln Leu 
    370                 375                 380                 


Lys Glu Asp Met Glu Lys Leu Asn Ala Thr Leu Asn Thr Gly Lys Glu 
385                 390                 395                 400 


Cys Gly Asp Glu Asn Ser Ser Pro Gln Met His Val Gly Ser Ala Ala 
                405                 410                 415     


Thr Lys Val Phe Val Cys Pro Val Val Ala Asn Phe Glu Phe Glu Leu 
            420                 425                 430         


Gln Leu Ser Leu Ile Cys Lys Ala Cys Gly His Ala Val Leu Lys Val 
        435                 440                 445             


Glu Pro Asn Asn Tyr Leu Ser Ile Asn Leu His Gln Glu Thr Lys Pro 
    450                 455                 460                 


Leu Pro Leu Ser Ile Gln Asn Ser Leu Asp Leu Phe Phe Lys Glu Glu 
465                 470                 475                 480 


Glu Leu Glu Tyr Asn Cys Gln Met Cys Lys Gln Lys Ser Cys Val Ala 
                485                 490                 495     


Arg His Thr Phe Ser Arg Leu Ser Arg Val Leu Ile Ile His Leu Lys 
            500                 505                 510         


Arg Tyr Ser Phe Asn Asn Ala Trp Leu Leu Val Lys Asn Asn Glu Gln 
        515                 520                 525             


Val Tyr Ile Pro Lys Ser Leu Ser Leu Ser Ser Tyr Cys Asn Glu Ser 
    530                 535                 540                 


Thr Lys Pro Pro Leu Pro Leu Ser Ser Ser Ala Pro Val Gly Lys Cys 
545                 550                 555                 560 


Glu Val Leu Glu Val Ser Gln Glu Met Ile Ser Glu Ile Asn Ser Pro 
                565                 570                 575     


Leu Thr Pro Ser Met Lys Leu Thr Ser Glu Ser Ser Asp Ser Leu Val 
            580                 585                 590         


Leu Pro Val Glu Pro Asp Lys Asn Ala Asp Leu Gln Arg Phe Gln Arg 
        595                 600                 605             


Asp Cys Gly Asp Ala Ser Gln Glu Gln His Gln Arg Asp Leu Glu Asn 
    610                 615                 620                 


Gly Ser Ala Leu Glu Ser Glu Leu Val His Phe Arg Asp Arg Ala Ile 
625                 630                 635                 640 


Gly Glu Lys Glu Leu Pro Val Ala Asp Ser Leu Met Asp Gln Gly Asp 
                645                 650                 655     


Ile Ser Leu Pro Val Met Tyr Glu Asp Gly Gly Lys Leu Ile Ser Ser 
            660                 665                 670         


Pro Asp Thr Arg Leu Val Glu Val His Leu Gln Glu Val Pro Gln His 
        675                 680                 685             


Pro Glu Leu Gln Lys Tyr Glu Lys Thr Asn Thr Phe Val Glu Phe Asn 
    690                 695                 700                 


Phe Asp Ser Val Thr Glu Ser Thr Asn Gly Phe Tyr Asp Cys Lys Glu 
705                 710                 715                 720 


Asn Arg Ile Pro Glu Gly Ser Gln Gly Met Ala Glu Gln Leu Gln Gln 
                725                 730                 735     


Cys Ile Glu Glu Ser Ile Ile Asp Glu Phe Leu Gln Gln Ala Pro Pro 
            740                 745                 750         


Pro Gly Val Arg Lys Leu Asp Ala Gln Glu His Thr Glu Glu Thr Leu 
        755                 760                 765             


Asn Gln Ser Thr Glu Leu Arg Leu Gln Lys Ala Asp Leu Asn His Leu 
    770                 775                 780                 


Gly Ala Leu Gly Ser Asp Asn Pro Gly Asn Lys Asn Ile Leu Asp Ala 
785                 790                 795                 800 


Glu Asn Thr Arg Gly Glu Ala Lys Glu Leu Thr Arg Asn Val Lys Met 
                805                 810                 815     


Gly Asp Pro Leu Gln Ala Tyr Arg Leu Ile Ser Val Val Ser His Ile 
            820                 825                 830         


Gly Ser Ser Pro Asn Ser Gly His Tyr Ile Ser Asp Val Tyr Asp Phe 
        835                 840                 845             


Gln Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Cys Val Ser Glu Ile 
    850                 855                 860                 


Ser Glu Thr Lys Met Gln Glu Ala Arg Leu His Ser Gly Tyr Ile Phe 
865                 870                 875                 880 


Phe Tyr Met His Asn Gly Ile Phe Glu Glu Leu Leu Arg Lys Ala Glu 
                885                 890                 895     


Asn Ser Arg Leu Pro Ser Thr Gln Ala Gly Val Ile Pro Gln Gly Glu 
            900                 905                 910         


Tyr Glu Gly Asp Ser Leu Tyr Arg Pro Ala 
        915                 920         


<210> 55
<211> 1406
<212> PRT
<213> Homo sapiens

<400> 55
Met Asp Met Val Glu Asn Ala Asp Ser Leu Gln Ala Gln Glu Arg Lys 
1               5                   10                  15      


Asp Ile Leu Met Lys Tyr Asp Lys Gly His Arg Ala Gly Leu Pro Glu 
            20                  25                  30          


Asp Lys Gly Pro Glu Pro Val Gly Ile Asn Ser Ser Ile Asp Arg Phe 
        35                  40                  45              


Gly Ile Leu His Glu Thr Glu Leu Pro Pro Val Thr Ala Arg Glu Ala 
    50                  55                  60                  


Lys Lys Ile Arg Arg Glu Met Thr Arg Thr Ser Lys Trp Met Glu Met 
65                  70                  75                  80  


Leu Gly Glu Trp Glu Thr Tyr Lys His Ser Ser Lys Leu Ile Asp Arg 
                85                  90                  95      


Val Tyr Lys Gly Ile Pro Met Asn Ile Arg Gly Pro Val Trp Ser Val 
            100                 105                 110         


Leu Leu Asn Ile Gln Glu Ile Lys Leu Lys Asn Pro Gly Arg Tyr Gln 
        115                 120                 125             


Ile Met Lys Glu Arg Gly Lys Arg Ser Ser Glu His Ile His His Ile 
    130                 135                 140                 


Asp Leu Asp Val Arg Thr Thr Leu Arg Asn His Val Phe Phe Arg Asp 
145                 150                 155                 160 


Arg Tyr Gly Ala Lys Gln Arg Glu Leu Phe Tyr Ile Leu Leu Ala Tyr 
                165                 170                 175     


Ser Glu Tyr Asn Pro Glu Val Gly Tyr Cys Arg Asp Leu Ser His Ile 
            180                 185                 190         


Thr Ala Leu Phe Leu Leu Tyr Leu Pro Glu Glu Asp Ala Phe Trp Ala 
        195                 200                 205             


Leu Val Gln Leu Leu Ala Ser Glu Arg His Ser Leu Pro Gly Phe His 
    210                 215                 220                 


Ser Pro Asn Gly Gly Thr Val Gln Gly Leu Gln Asp Gln Gln Glu His 
225                 230                 235                 240 


Val Val Pro Lys Ser Gln Pro Lys Thr Met Trp His Gln Asp Lys Glu 
                245                 250                 255     


Gly Leu Cys Gly Gln Cys Ala Ser Leu Gly Cys Leu Leu Arg Asn Leu 
            260                 265                 270         


Ile Asp Gly Ile Ser Leu Gly Leu Thr Leu Arg Leu Trp Asp Val Tyr 
        275                 280                 285             


Leu Val Glu Gly Glu Gln Val Leu Met Pro Ile Thr Ser Ile Ala Leu 
    290                 295                 300                 


Lys Val Gln Gln Lys Arg Leu Met Lys Thr Ser Arg Cys Gly Leu Trp 
305                 310                 315                 320 


Ala Arg Leu Arg Asn Gln Phe Phe Asp Thr Trp Ala Met Asn Asp Asp 
                325                 330                 335     


Thr Val Leu Lys His Leu Arg Ala Ser Thr Lys Lys Leu Thr Arg Lys 
            340                 345                 350         


Gln Gly Asp Leu Pro Pro Pro Ala Lys Arg Glu Gln Gly Ser Leu Ala 
        355                 360                 365             


Pro Arg Pro Val Pro Ala Ser Arg Gly Gly Lys Thr Leu Cys Lys Gly 
    370                 375                 380                 


Tyr Arg Gln Ala Pro Pro Gly Pro Pro Ala Gln Phe Gln Arg Pro Ile 
385                 390                 395                 400 


Cys Ser Ala Ser Pro Pro Trp Ala Ser Arg Phe Ser Thr Pro Cys Pro 
                405                 410                 415     


Gly Gly Ala Val Arg Glu Asp Thr Tyr Pro Val Gly Thr Gln Gly Val 
            420                 425                 430         


Pro Ser Leu Ala Leu Ala Gln Gly Gly Pro Gln Gly Ser Trp Arg Phe 
        435                 440                 445             


Leu Glu Trp Lys Ser Met Pro Arg Leu Pro Thr Asp Leu Asp Ile Gly 
    450                 455                 460                 


Gly Pro Trp Phe Pro His Tyr Asp Phe Glu Trp Ser Cys Trp Val Arg 
465                 470                 475                 480 


Ala Ile Ser Gln Glu Asp Gln Leu Ala Thr Cys Trp Gln Ala Glu His 
                485                 490                 495     


Cys Gly Glu Val His Asn Lys Asp Met Ser Trp Pro Glu Glu Met Ser 
            500                 505                 510         


Phe Thr Ala Asn Ser Ser Lys Ile Asp Arg Gln Lys Val Pro Thr Glu 
        515                 520                 525             


Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn 
    530                 535                 540                 


Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe 
545                 550                 555                 560 


Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly 
                565                 570                 575     


Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu 
            580                 585                 590         


Trp Ser Gly Thr Gln Lys Ser Val Ala Pro Leu Lys Leu Arg Arg Thr 
        595                 600                 605             


Ile Ala Lys Tyr Ala Pro Lys Phe Asp Gly Phe Gln Gln Gln Asp Ser 
    610                 615                 620                 


Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn 
625                 630                 635                 640 


Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg 
                645                 650                 655     


Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg 
            660                 665                 670         


Asn Arg Ser Ile Ile Val Asp Leu Phe His Gly Gln Leu Arg Ser Gln 
        675                 680                 685             


Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Phe 
    690                 695                 700                 


Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met Asp Leu Glu 
705                 710                 715                 720 


Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu 
                725                 730                 735     


Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Arg 
            740                 745                 750         


Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His 
        755                 760                 765             


Asp Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Gln Leu 
    770                 775                 780                 


Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Ser Ser 
785                 790                 795                 800 


Pro Ile Ser Ala Ser Ser Pro Thr Gln Ile Asp Phe Ser Ser Ser Pro 
                805                 810                 815     


Ser Thr Asn Gly Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Lys 
            820                 825                 830         


Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly 
        835                 840                 845             


Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser 
    850                 855                 860                 


Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys 
865                 870                 875                 880 


Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Pro Gln Glu Asn Arg Pro 
                885                 890                 895     


Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg 
            900                 905                 910         


Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Trp Leu Ala 
        915                 920                 925             


Arg Pro Leu Pro Pro Gln Glu Ala Ser Ile His Ala Gln Asp Arg Asp 
    930                 935                 940                 


Asn Cys Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys 
945                 950                 955                 960 


Asp Gly Asn Ser Cys Ala Trp Cys Pro Gln Tyr Arg Phe Cys Arg Gly 
                965                 970                 975     


Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr 
            980                 985                 990         


Ile Ala Val Asp Trp His Pro Thr  Ala Leu His Leu Arg  Tyr Gln Thr 
        995                 1000                 1005             


Ser Gln  Glu Arg Val Val Asp  Lys His Glu Ser Val  Glu Gln Ser 
    1010                 1015                 1020             


Arg Arg  Ala Gln Ala Glu Pro  Ile Asn Leu Asp Ser  Cys Leu Arg 
    1025                 1030                 1035             


Ala Phe  Thr Ser Glu Glu Glu  Leu Gly Glu Ser Glu  Met Tyr Tyr 
    1040                 1045                 1050             


Cys Ser  Lys Cys Lys Thr His  Cys Leu Ala Thr Lys  Lys Leu Asp 
    1055                 1060                 1065             


Leu Trp  Arg Leu Pro Pro Phe  Leu Ile Ile His Leu  Lys Arg Phe 
    1070                 1075                 1080             


Gln Phe  Val Asn Asp Gln Trp  Ile Lys Ser Gln Lys  Ile Val Arg 
    1085                 1090                 1095             


Phe Leu  Arg Glu Ser Phe Asp  Pro Ser Ala Phe Leu  Val Pro Arg 
    1100                 1105                 1110             


Asp Pro  Ala Leu Cys Gln His  Lys Pro Leu Thr Pro  Gln Gly Asp 
    1115                 1120                 1125             


Glu Leu  Ser Lys Pro Arg Ile  Leu Ala Arg Glu Val  Lys Lys Val 
    1130                 1135                 1140             


Asp Ala  Gln Ser Ser Ala Gly  Lys Glu Asp Met Leu  Leu Ser Lys 
    1145                 1150                 1155             


Ser Pro  Ser Ser Leu Ser Ala  Asn Ile Ser Ser Ser  Pro Lys Gly 
    1160                 1165                 1170             


Ser Pro  Ser Ser Ser Arg Lys  Ser Gly Thr Ser Cys  Pro Ser Ser 
    1175                 1180                 1185             


Lys Asn  Ser Ser Pro Asn Ser  Ser Pro Arg Thr Leu  Gly Arg Ser 
    1190                 1195                 1200             


Lys Gly  Arg Leu Arg Leu Pro  Gln Ile Gly Ser Lys  Asn Lys Pro 
    1205                 1210                 1215             


Ser Ser  Ser Lys Lys Asn Leu  Asp Ala Ser Lys Glu  Asn Gly Ala 
    1220                 1225                 1230             


Gly Gln  Ile Cys Glu Leu Ala  Asp Ala Leu Ser Arg  Gly His Met 
    1235                 1240                 1245             


Arg Gly  Gly Ser Gln Pro Glu  Leu Val Thr Pro Gln  Asp His Glu 
    1250                 1255                 1260             


Val Ala  Leu Ala Asn Gly Phe  Leu Tyr Glu His Glu  Ala Cys Gly 
    1265                 1270                 1275             


Asn Gly  Cys Gly Asp Gly Tyr  Ser Asn Gly Gln Leu  Gly Asn His 
    1280                 1285                 1290             


Ser Glu  Glu Asp Ser Thr Asp  Asp Gln Arg Glu Asp  Thr His Ile 
    1295                 1300                 1305             


Lys Pro  Ile Tyr Asn Leu Tyr  Ala Ile Ser Cys His  Ser Gly Ile 
    1310                 1315                 1320             


Leu Ser  Gly Gly His Tyr Ile  Thr Tyr Ala Lys Asn  Pro Asn Cys 
    1325                 1330                 1335             


Lys Trp  Tyr Cys Tyr Asn Asp  Ser Ser Cys Glu Glu  Leu His Pro 
    1340                 1345                 1350             


Asp Glu  Ile Asp Thr Asp Ser  Ala Tyr Ile Leu Phe  Tyr Glu Gln 
    1355                 1360                 1365             


Gln Gly  Ile Asp Tyr Ala Gln  Phe Leu Pro Lys Ile  Asp Gly Lys 
    1370                 1375                 1380             


Lys Met  Ala Asp Thr Ser Ser  Thr Asp Glu Asp Ser  Glu Ser Asp 
    1385                 1390                 1395             


Tyr Glu  Lys Tyr Ser Met Leu  Gln 
    1400                 1405     


<210> 56
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Trp Val Lys Phe Leu Arg Lys Pro Gly Gly Asn Leu Gly Lys 
1               5                   10                  15      


Val Tyr Gln Pro Gly Ser Met Leu Ser Leu Ala Pro Thr Lys Gly Leu 
            20                  25                  30          


Leu Asn Glu Pro Gly Gln Asn Ser Cys Phe Leu Asn Ser Ala Val Gln 
        35                  40                  45              


Val Leu Trp Gln Leu Asp Ile Phe Arg Arg Ser Leu Arg Val Leu Thr 
    50                  55                  60                  


Gly His Val Cys Gln Gly Asp Ala Cys Ile Phe Cys Ala Leu Lys Thr 
65                  70                  75                  80  


Ile Phe Ala Gln Phe Gln His Ser Arg Glu Lys Ala Leu Pro Ser Asp 
                85                  90                  95      


Asn Ile Arg His Ala Leu Ala Glu Ser Phe Lys Asp Glu Gln Arg Phe 
            100                 105                 110         


Gln Leu Gly Leu Met Asp Asp Ala Ala Glu Cys Phe Glu Asn Met Leu 
        115                 120                 125             


Glu Arg Ile His Phe His Ile Val Pro Ser Arg Asp Ala Asp Met Cys 
    130                 135                 140                 


Thr Ser Lys Ser Cys Ile Thr His Gln Lys Phe Ala Met Thr Leu Tyr 
145                 150                 155                 160 


Glu Gln Cys Val Cys Arg Ser Cys Gly Ala Ser Ser Asp Pro Leu Pro 
                165                 170                 175     


Phe Thr Glu Phe Val Arg Tyr Ile Ser Thr Thr Ala Leu Cys Asn Glu 
            180                 185                 190         


Val Glu Arg Met Leu Glu Arg His Glu Arg Phe Lys Pro Glu Met Phe 
        195                 200                 205             


Ala Glu Leu Leu Gln Ala Ala Asn Thr Thr Asp Asp Tyr Arg Lys Cys 
    210                 215                 220                 


Pro Ser Asn Cys Gly Gln Lys Ile Lys Ile Arg Arg Val Leu Met Asn 
225                 230                 235                 240 


Cys Pro Glu Ile Val Thr Ile Gly Leu Val Trp Asp Ser Glu His Ser 
                245                 250                 255     


Asp Leu Thr Glu Ala Val Val Arg Asn Leu Ala Thr His Leu Tyr Leu 
            260                 265                 270         


Pro Gly Leu Phe Tyr Arg Val Thr Asp Glu Asn Ala Lys Asn Ser Glu 
        275                 280                 285             


Leu Asn Leu Val Gly Met Ile Cys Tyr Thr Ser Gln His Tyr Cys Ala 
    290                 295                 300                 


Phe Ala Phe His Thr Lys Ser Ser Lys Trp Val Phe Phe Asp Asp Ala 
305                 310                 315                 320 


Asn Val Lys Glu Ile Gly Thr Arg Trp Lys Asp Val Val Ser Lys Cys 
                325                 330                 335     


Ile Arg Cys His Phe Gln Pro Leu Leu Leu Phe Tyr Ala Asn Pro Asp 
            340                 345                 350         


Gly Thr Ala Val Ser Thr Glu Asp Ala Leu Arg Gln Val Ile Ser Trp 
        355                 360                 365             


Ser His Tyr Lys Ser Val Ala Glu Asn Met Gly Cys Glu Lys Pro Val 
    370                 375                 380                 


Ile His Lys Ser Asp Asn Leu Lys Glu Asn Gly Phe Gly Asp Gln Ala 
385                 390                 395                 400 


Lys Gln Arg Glu Asn Gln Lys Phe Pro Thr Asp Asn Ile Ser Ser Ser 
                405                 410                 415     


Asn Arg Ser His Ser His Thr Gly Val Gly Lys Gly Pro Ala Lys Leu 
            420                 425                 430         


Ser His Ile Asp Gln Arg Glu Lys Ile Lys Asp Ile Ser Arg Glu Cys 
        435                 440                 445             


Ala Leu Lys Ala Ile Glu Gln Lys Asn Leu Leu Ser Ser Gln Arg Lys 
    450                 455                 460                 


Asp Leu Glu Lys Gly Gln Arg Lys Asp Leu Gly Arg His Arg Asp Leu 
465                 470                 475                 480 


Val Asp Glu Asp Leu Ser His Phe Gln Ser Gly Ser Pro Pro Ala Pro 
                485                 490                 495     


Asn Gly Phe Lys Gln His Gly Asn Pro His Leu Tyr His Ser Gln Gly 
            500                 505                 510         


Lys Gly Ser Tyr Lys His Asp Arg Val Val Pro Gln Ser Arg Ala Ser 
        515                 520                 525             


Ala Gln Ile Ile Ser Ser Ser Lys Ser Gln Ile Leu Ala Pro Gly Glu 
    530                 535                 540                 


Lys Ile Thr Gly Lys Val Lys Ser Asp Asn Gly Thr Gly Tyr Asp Thr 
545                 550                 555                 560 


Asp Ser Ser Gln Asp Ser Arg Asp Arg Gly Asn Ser Cys Asp Ser Ser 
                565                 570                 575     


Ser Lys Ser Arg Asn Arg Gly Trp Lys Pro Met Arg Glu Thr Leu Asn 
            580                 585                 590         


Val Asp Ser Ile Phe Ser Glu Ser Glu Lys Arg Gln His Ser Pro Arg 
        595                 600                 605             


His Lys Pro Asn Ile Ser Asn Lys Pro Lys Ser Ser Lys Asp Pro Ser 
    610                 615                 620                 


Phe Ser Asn Trp Pro Lys Glu Asn Pro Lys Gln Lys Gly Leu Met Thr 
625                 630                 635                 640 


Ile Tyr Glu Asp Glu Met Lys Gln Glu Ile Gly Ser Arg Ser Ser Leu 
                645                 650                 655     


Glu Ser Asn Gly Lys Gly Ala Glu Lys Asn Lys Gly Leu Val Glu Gly 
            660                 665                 670         


Lys Val His Gly Asp Asn Trp Gln Met Gln Arg Thr Glu Ser Gly Tyr 
        675                 680                 685             


Glu Ser Ser Asp His Ile Ser Asn Gly Ser Thr Asn Leu Asp Ser Pro 
    690                 695                 700                 


Val Ile Asp Gly Asn Gly Thr Val Met Asp Ile Ser Gly Val Lys Glu 
705                 710                 715                 720 


Thr Val Cys Phe Ser Asp Gln Ile Thr Thr Ser Asn Leu Asn Lys Glu 
                725                 730                 735     


Arg Gly Asp Cys Thr Ser Leu Gln Ser Gln His His Leu Glu Gly Phe 
            740                 745                 750         


Arg Lys Glu Leu Arg Asn Leu Glu Ala Gly Tyr Lys Ser His Glu Phe 
        755                 760                 765             


His Pro Glu Ser His Leu Gln Ile Lys Asn His Leu Ile Lys Arg Ser 
    770                 775                 780                 


His Val His Glu Asp Asn Gly Lys Leu Phe Pro Ser Ser Ser Leu Gln 
785                 790                 795                 800 


Ile Pro Lys Asp His Asn Ala Arg Glu His Ile His Gln Ser Asp Glu 
                805                 810                 815     


Gln Lys Leu Glu Lys Pro Asn Glu Cys Lys Phe Ser Glu Trp Leu Asn 
            820                 825                 830         


Ile Glu Asn Ser Glu Arg Thr Gly Leu Pro Phe His Val Asp Asn Ser 
        835                 840                 845             


Ala Ser Gly Lys Arg Val Asn Ser Asn Glu Pro Ser Ser Leu Trp Ser 
    850                 855                 860                 


Ser His Leu Arg Thr Val Gly Leu Lys Pro Glu Thr Ala Pro Leu Ile 
865                 870                 875                 880 


Gln Gln Gln Asn Ile Met Asp Gln Cys Tyr Phe Glu Asn Ser Leu Ser 
                885                 890                 895     


Thr Glu Cys Ile Ile Arg Ser Ala Ser Arg Ser Asp Gly Cys Gln Met 
            900                 905                 910         


Pro Lys Leu Phe Cys Gln Asn Leu Pro Pro Pro Leu Pro Pro Lys Lys 
        915                 920                 925             


Tyr Ala Ile Thr Ser Val Pro Gln Ser Glu Lys Ser Glu Ser Thr Pro 
    930                 935                 940                 


Asp Val Lys Leu Thr Glu Val Phe Lys Ala Thr Ser His Leu Pro Lys 
945                 950                 955                 960 


His Ser Leu Ser Thr Ala Ser Glu Pro Ser Leu Glu Val Ser Thr His 
                965                 970                 975     


Met Asn Asp Glu Arg His Lys Glu Thr Phe Gln Val Arg Glu Cys Phe 
            980                 985                 990         


Gly Asn Thr Pro Asn Cys Pro Ser  Ser Ser Ser Thr Asn  Asp Phe Gln 
        995                 1000                 1005             


Ala Asn  Ser Gly Ala Ile Asp  Ala Phe Cys Gln Pro  Glu Leu Asp 
    1010                 1015                 1020             


Ser Ile  Ser Thr Cys Pro Asn  Glu Thr Val Ser Leu  Thr Thr Tyr 
    1025                 1030                 1035             


Phe Ser  Val Asp Ser Cys Met  Thr Asp Thr Tyr Arg  Leu Lys Tyr 
    1040                 1045                 1050             


His Gln  Arg Pro Lys Leu Ser  Phe Pro Glu Ser Ser  Gly Phe Cys 
    1055                 1060                 1065             


Asn Asn  Ser Leu Ser 
    1070             


<210> 57
<211> 1060
<212> PRT
<213> Homo sapiens

<400> 57
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe 
    530                 535                 540                 


Asn His Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala 
545                 550                 555                 560 


Glu Ile Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu 
                565                 570                 575     


Thr Arg Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu 
            580                 585                 590         


Ala Pro Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val 
        595                 600                 605             


Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser 
    610                 615                 620                 


Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser 
625                 630                 635                 640 


Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys 
                645                 650                 655     


Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val 
            660                 665                 670         


Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln 
        675                 680                 685             


Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys 
    690                 695                 700                 


Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr 
705                 710                 715                 720 


Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys 
                725                 730                 735     


Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp 
            740                 745                 750         


Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu 
        755                 760                 765             


Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys 
    770                 775                 780                 


Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His 
785                 790                 795                 800 


Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val 
                805                 810                 815     


Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp 
            820                 825                 830         


Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val 
        835                 840                 845             


Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His 
    850                 855                 860                 


Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp 
865                 870                 875                 880 


Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln 
                885                 890                 895     


Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser 
            900                 905                 910         


Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp 
        915                 920                 925             


Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys 
    930                 935                 940                 


Leu Gln Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln 
945                 950                 955                 960 


Glu Ser Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr 
                965                 970                 975     


Lys Pro Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp 
            980                 985                 990         


Val Leu Val Ile His Gln Ser Lys  Tyr Lys Cys Gly Met  Lys Asn His 
        995                 1000                 1005             


His Pro  Glu Gln Gln Ser Ser  Leu Leu Lys Leu Ser  Ser Thr Thr 
    1010                 1015                 1020             


Pro Thr  His Gln Glu Ser Met  Asn Thr Gly Thr Leu  Ala Ser Leu 
    1025                 1030                 1035             


Arg Gly  Arg Ala Arg Arg Ser  Lys Gly Lys Asn Lys  His Ser Lys 
    1040                 1045                 1050             


Arg Ala  Leu Leu Val Cys Gln  
    1055                 1060 


<210> 58
<211> 858
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile 
1               5                   10                  15      


Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe 
            20                  25                  30          


Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn 
        35                  40                  45              


Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys 
    50                  55                  60                  


Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys 
65                  70                  75                  80  


Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro 
                85                  90                  95      


Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu 
            100                 105                 110         


Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr 
        115                 120                 125             


Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg 
    130                 135                 140                 


Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala 
145                 150                 155                 160 


Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val 
                165                 170                 175     


Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile 
            180                 185                 190         


Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu 
        195                 200                 205             


Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe 
    210                 215                 220                 


Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr 
225                 230                 235                 240 


Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala 
                245                 250                 255     


Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu 
            260                 265                 270         


Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys 
        275                 280                 285             


Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile 
    290                 295                 300                 


Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu 
305                 310                 315                 320 


Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
                325                 330                 335     


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            340                 345                 350         


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        355                 360                 365             


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    370                 375                 380                 


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
385                 390                 395                 400 


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                405                 410                 415     


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            420                 425                 430         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        435                 440                 445             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    450                 455                 460                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
465                 470                 475                 480 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                485                 490                 495     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            500                 505                 510         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        515                 520                 525             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    530                 535                 540                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
545                 550                 555                 560 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                565                 570                 575     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            580                 585                 590         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        595                 600                 605             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    610                 615                 620                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
625                 630                 635                 640 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                645                 650                 655     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            660                 665                 670         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        675                 680                 685             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    690                 695                 700                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
705                 710                 715                 720 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                725                 730                 735     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            740                 745                 750         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        755                 760                 765             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    770                 775                 780                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
785                 790                 795                 800 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                805                 810                 815     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            820                 825                 830         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        835                 840                 845             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser 
    850                 855             


<210> 59
<211> 1055
<212> PRT
<213> Homo sapiens

<400> 59
Met Thr Val Glu Gln Asn Val Leu Gln Gln Ser Ala Ala Gln Lys His 
1               5                   10                  15      


Gln Gln Thr Phe Leu Asn Gln Leu Arg Glu Ile Thr Gly Ile Asn Asp 
            20                  25                  30          


Thr Gln Ile Leu Gln Gln Ala Leu Lys Asp Ser Asn Gly Asn Leu Glu 
        35                  40                  45              


Leu Ala Val Ala Phe Leu Thr Ala Lys Asn Ala Lys Thr Pro Gln Gln 
    50                  55                  60                  


Glu Glu Thr Thr Tyr Tyr Gln Thr Ala Leu Pro Gly Asn Asp Arg Tyr 
65                  70                  75                  80  


Ile Ser Val Gly Ser Gln Ala Asp Thr Asn Val Ile Asp Leu Thr Gly 
                85                  90                  95      


Asp Asp Lys Asp Asp Leu Gln Arg Ala Ile Ala Leu Ser Leu Ala Glu 
            100                 105                 110         


Ser Asn Arg Ala Phe Arg Glu Thr Gly Ile Thr Asp Glu Glu Gln Ala 
        115                 120                 125             


Ile Ser Arg Val Leu Glu Ala Ser Ile Ala Glu Asn Lys Ala Cys Leu 
    130                 135                 140                 


Lys Arg Thr Pro Thr Glu Val Trp Arg Asp Ser Arg Asn Pro Tyr Asp 
145                 150                 155                 160 


Arg Lys Arg Gln Asp Lys Ala Pro Val Gly Leu Lys Asn Val Gly Asn 
                165                 170                 175     


Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe Asn Leu Leu Glu 
            180                 185                 190         


Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser Asn Ala Gln Asp 
        195                 200                 205             


Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro Phe Met Arg Glu 
    210                 215                 220                 


Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys Arg Lys Tyr Val 
225                 230                 235                 240 


Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala Phe Lys Ser Asn 
                245                 250                 255     


Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp 
            260                 265                 270         


Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu Glu Thr Asp Glu 
        275                 280                 285             


Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr Gly Arg Phe Leu 
    290                 295                 300                 


Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn Thr Glu Met Phe 
305                 310                 315                 320 


Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp Leu His Glu Cys 
                325                 330                 335     


Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser Leu His Ser Glu 
            340                 345                 350         


Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr Glu Leu Pro Pro 
        355                 360                 365             


Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn Gln Ala Leu Gly 
    370                 375                 380                 


Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro Gln Val Leu Tyr 
385                 390                 395                 400 


Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr Arg Ile Lys Arg 
                405                 410                 415     


Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val Leu Gln Gln Arg 
            420                 425                 430         


Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys Arg Phe Pro Leu 
        435                 440                 445             


Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser Ser Lys Pro Val 
    450                 455                 460                 


Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser Pro Pro Ser Gly 
465                 470                 475                 480 


Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu Gln Gln Gly Ala 
                485                 490                 495     


Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser Val Ala Ala Ile 
            500                 505                 510         


Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln Ser Arg Ile Pro 
        515                 520                 525             


Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile Thr Glu Glu Glu 
    530                 535                 540                 


Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg Thr Glu Ile Glu 
545                 550                 555                 560 


Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg Ile His Arg Thr 
                565                 570                 575     


Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln Val Pro Tyr Arg 
            580                 585                 590         


Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn Ala Gly His Tyr 
        595                 600                 605             


Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp Met Lys Tyr Asn 
    610                 615                 620                 


Asp Ile Ala Val Thr Lys Ser Ser Trp Glu Glu Leu Val Arg Asp Ser 
625                 630                 635                 640 


Phe Gly Gly Tyr Arg Asn Ala Ser Ala Tyr Cys Leu Met Tyr Ile Asn 
                645                 650                 655     


Asp Lys Ala Gln Phe Leu Ile Gln Glu Glu Phe Asn Lys Glu Thr Gly 
            660                 665                 670         


Gln Pro Leu Val Gly Ile Glu Thr Leu Pro Pro Asp Leu Arg Asp Phe 
        675                 680                 685             


Val Glu Glu Asp Asn Gln Arg Phe Glu Lys Glu Leu Glu Glu Trp Asp 
    690                 695                 700                 


Ala Gln Leu Ala Gln Lys Ala Leu Gln Glu Lys Leu Leu Ala Ser Gln 
705                 710                 715                 720 


Lys Leu Arg Glu Ser Glu Thr Ser Val Thr Thr Ala Gln Ala Ala Gly 
                725                 730                 735     


Asp Pro Glu Tyr Leu Glu Gln Pro Ser Arg Ser Asp Phe Ser Lys His 
            740                 745                 750         


Leu Lys Glu Glu Thr Ile Gln Ile Ile Thr Lys Ala Ser His Glu His 
        755                 760                 765             


Glu Asp Lys Ser Pro Glu Thr Val Leu Gln Ser Ala Ile Lys Leu Glu 
    770                 775                 780                 


Tyr Ala Arg Leu Val Lys Leu Ala Gln Glu Asp Thr Pro Pro Glu Thr 
785                 790                 795                 800 


Asp Tyr Arg Leu His His Val Val Val Tyr Phe Ile Gln Asn Gln Ala 
                805                 810                 815     


Pro Lys Lys Ile Ile Glu Lys Thr Leu Leu Glu Gln Phe Gly Asp Arg 
            820                 825                 830         


Asn Leu Ser Phe Asp Glu Arg Cys His Asn Ile Met Lys Val Ala Gln 
        835                 840                 845             


Ala Lys Leu Glu Met Ile Lys Pro Glu Glu Val Asn Leu Glu Glu Tyr 
    850                 855                 860                 


Glu Glu Trp His Gln Asp Tyr Arg Lys Phe Arg Glu Thr Thr Met Tyr 
865                 870                 875                 880 


Leu Ile Ile Gly Leu Glu Asn Phe Gln Arg Glu Ser Tyr Ile Asp Ser 
                885                 890                 895     


Leu Leu Phe Leu Ile Cys Ala Tyr Gln Asn Asn Lys Glu Leu Leu Ser 
            900                 905                 910         


Lys Gly Leu Tyr Arg Gly His Asp Glu Glu Leu Ile Ser His Tyr Arg 
        915                 920                 925             


Arg Glu Cys Leu Leu Lys Leu Asn Glu Gln Ala Ala Glu Leu Phe Glu 
    930                 935                 940                 


Ser Gly Glu Asp Arg Glu Val Asn Asn Gly Leu Ile Ile Met Asn Glu 
945                 950                 955                 960 


Phe Ile Val Pro Phe Leu Pro Leu Leu Leu Val Asp Glu Met Glu Glu 
                965                 970                 975     


Lys Asp Ile Leu Ala Val Glu Asp Met Arg Asn Arg Trp Cys Ser Tyr 
            980                 985                 990         


Leu Gly Gln Glu Met Glu Pro His  Leu Gln Glu Lys Leu  Thr Asp Phe 
        995                 1000                 1005             


Leu Pro  Lys Leu Leu Asp Cys  Ser Met Glu Ile Lys  Ser Phe His 
    1010                 1015                 1020             


Glu Pro  Pro Lys Leu Pro Ser  Tyr Ser Thr His Glu  Leu Cys Glu 
    1025                 1030                 1035             


Arg Phe  Ala Arg Ile Met Leu  Ser Leu Ser Arg Thr  Pro Ala Asp 
    1040                 1045                 1050             


Gly Arg  
    1055 


<210> 60
<211> 942
<212> PRT
<213> Homo sapiens

<400> 60
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Lys Val Leu 
1               5                   10                  15      


Pro His Phe Glu Ser Leu Gly Lys Gln Glu Lys Ile Pro Asn Lys Met 
            20                  25                  30          


Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu Ile 
        35                  40                  45              


Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp Cys 
    50                  55                  60                  


Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys Ser 
65                  70                  75                  80  


Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His Ser 
                85                  90                  95      


Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg Val 
            100                 105                 110         


Trp Cys Tyr Ala Cys Ser Lys Glu Val Phe Leu Asp Arg Lys Leu Gly 
        115                 120                 125             


Thr Gln Pro Ser Leu Pro His Val Arg Gln Pro His Gln Ile Gln Glu 
    130                 135                 140                 


Asn Ser Val Gln Asp Phe Lys Ile Pro Ser Asn Thr Thr Leu Lys Thr 
145                 150                 155                 160 


Pro Leu Val Ala Val Phe Asp Asp Leu Asp Ile Glu Ala Asp Glu Glu 
                165                 170                 175     


Asp Glu Leu Arg Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn 
            180                 185                 190         


Thr Cys Tyr Met Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro 
        195                 200                 205             


Leu Thr Gln Phe Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys 
    210                 215                 220                 


Lys Pro Ala Ile Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp 
225                 230                 235                 240 


His Lys Ser Arg Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly 
                245                 250                 255     


Ile Lys Thr Val Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala 
            260                 265                 270         


Gln Glu Phe Leu Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys 
        275                 280                 285             


Glu Gln Val Met Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu 
    290                 295                 300                 


Glu Thr Met Glu Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser 
305                 310                 315                 320 


Cys Glu Ser Cys Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser 
                325                 330                 335     


Arg Cys Phe Ser Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp 
            340                 345                 350         


Asp Glu Asn Asn Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met 
        355                 360                 365             


Cys Asn Lys Ile Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp 
    370                 375                 380                 


Arg Asp Ser Ile Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val 
385                 390                 395                 400 


Lys Val Gln Ile His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His 
                405                 410                 415     


Ser Asn Asp Leu Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val 
            420                 425                 430         


Asn Pro Arg Leu Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro 
        435                 440                 445             


Gly Leu Ala Pro Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg 
    450                 455                 460                 


Lys Lys Gln His Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp 
465                 470                 475                 480 


Gly Thr Ile Ile Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser 
                485                 490                 495     


Val Thr Leu Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys 
            500                 505                 510         


Glu Asp Leu Ala Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val 
        515                 520                 525             


Lys Ala Gly Ser Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala 
    530                 535                 540                 


Phe Phe Met Glu Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro Ser 
545                 550                 555                 560 


Trp Phe Trp Gly Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala Phe 
                565                 570                 575     


Phe Ala Arg Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu Lys 
            580                 585                 590         


Cys Lys Lys Leu Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn Phe 
        595                 600                 605             


Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu Leu Met 
    610                 615                 620                 


Phe Ser Thr Lys Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly Leu 
625                 630                 635                 640 


Asp Leu Gln Pro Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val Thr 
                645                 650                 655     


Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Ser Ser Gly 
            660                 665                 670         


His Tyr Ile Ala Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr Glu 
        675                 680                 685             


Phe Asp Asp Gln Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln Asn 
    690                 695                 700                 


Ala Glu Ala Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu Ala Gln 
705                 710                 715                 720 


Lys Glu Arg Arg Arg Ile Ser Asn Leu Leu Asn Ile Met Glu Pro Ser 
                725                 730                 735     


Leu Leu Gln Phe Tyr Ile Ser Arg Gln Trp Leu Asn Lys Phe Lys Thr 
            740                 745                 750         


Phe Ala Glu Pro Gly Pro Ile Ser Asn Asn Asp Phe Leu Cys Ile His 
        755                 760                 765             


Gly Gly Val Pro Pro Arg Lys Ala Gly Tyr Ile Glu Asp Leu Val Leu 
    770                 775                 780                 


Met Leu Pro Gln Asn Ile Trp Asp Asn Leu Tyr Ser Arg Tyr Gly Gly 
785                 790                 795                 800 


Gly Pro Ala Val Asn His Leu Tyr Ile Cys His Thr Cys Gln Ile Glu 
                805                 810                 815     


Ala Glu Lys Ile Glu Lys Arg Arg Lys Thr Glu Leu Glu Ile Phe Ile 
            820                 825                 830         


Arg Leu Asn Arg Ala Phe Gln Lys Glu Asp Ser Pro Ala Thr Phe Tyr 
        835                 840                 845             


Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ser Phe Val Lys Gly 
    850                 855                 860                 


Lys Asp Gly Asp Pro Pro Gly Pro Ile Asp Asn Thr Lys Ile Ala Val 
865                 870                 875                 880 


Thr Lys Cys Gly Asn Val Met Leu Arg Gln Gly Ala Asp Ser Gly Gln 
                885                 890                 895     


Ile Ser Glu Glu Thr Trp Asn Phe Leu Gln Ser Ile Tyr Gly Gly Gly 
            900                 905                 910         


Pro Glu Val Ile Leu Arg Pro Pro Val Val His Val Asp Pro Asp Ile 
        915                 920                 925             


Leu Gln Ala Glu Glu Lys Ile Glu Val Glu Thr Arg Ser Leu 
    930                 935                 940         


<210> 61
<211> 565
<212> PRT
<213> Homo sapiens

<400> 61
Met Pro Gln Ala Ser Glu His Arg Leu Gly Arg Thr Arg Glu Pro Pro 
1               5                   10                  15      


Val Asn Ile Gln Pro Arg Val Gly Ser Lys Leu Pro Phe Ala Pro Arg 
            20                  25                  30          


Ala Arg Ser Lys Glu Arg Arg Asn Pro Ala Ser Gly Pro Asn Pro Met 
        35                  40                  45              


Leu Arg Pro Leu Pro Pro Arg Pro Gly Leu Pro Asp Glu Arg Leu Lys 
    50                  55                  60                  


Lys Leu Glu Leu Gly Arg Gly Arg Thr Ser Gly Pro Arg Pro Arg Gly 
65                  70                  75                  80  


Pro Leu Arg Ala Asp His Gly Val Pro Leu Pro Gly Ser Pro Pro Pro 
                85                  90                  95      


Thr Val Ala Leu Pro Leu Pro Ser Arg Thr Asn Leu Ala Arg Ser Lys 
            100                 105                 110         


Ser Val Ser Ser Gly Asp Leu Arg Pro Met Gly Ile Ala Leu Gly Gly 
        115                 120                 125             


His Arg Gly Thr Gly Glu Leu Gly Ala Ala Leu Ser Arg Leu Ala Leu 
    130                 135                 140                 


Arg Pro Glu Pro Pro Thr Leu Arg Arg Ser Thr Ser Leu Arg Arg Leu 
145                 150                 155                 160 


Gly Gly Phe Pro Gly Pro Pro Thr Leu Phe Ser Ile Arg Thr Glu Pro 
                165                 170                 175     


Pro Ala Ser His Gly Ser Phe His Met Ile Ser Ala Arg Ser Ser Glu 
            180                 185                 190         


Pro Phe Tyr Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly 
        195                 200                 205             


Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn 
    210                 215                 220                 


Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys 
225                 230                 235                 240 


Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln 
                245                 250                 255     


Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro 
            260                 265                 270         


Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln 
        275                 280                 285             


Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu 
    290                 295                 300                 


Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg 
305                 310                 315                 320 


Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro 
                325                 330                 335     


Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp 
            340                 345                 350         


Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser 
        355                 360                 365             


Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys 
    370                 375                 380                 


Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu 
385                 390                 395                 400 


Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu 
                405                 410                 415     


Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu 
            420                 425                 430         


Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys 
        435                 440                 445             


Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn 
    450                 455                 460                 


Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val 
465                 470                 475                 480 


Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys 
                485                 490                 495     


Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly 
            500                 505                 510         


Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly 
        515                 520                 525             


Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln 
    530                 535                 540                 


Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu 
545                 550                 555                 560 


Pro Pro Arg Cys Leu 
                565 


<210> 62
<211> 530
<212> PRT
<213> Homo sapiens

<400> 62
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly Tyr Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Glu Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Met Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Met Asn Ser Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 63
<211> 530
<212> PRT
<213> Homo sapiens

<400> 63
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 64
<211> 370
<212> PRT
<213> Homo sapiens

<400> 64
Met Glu Ile Leu Met Thr Val Ser Lys Phe Ala Ser Ile Cys Thr Met 
1               5                   10                  15      


Gly Ala Asn Ala Ser Ala Leu Glu Lys Glu Ile Gly Pro Glu Gln Phe 
            20                  25                  30          


Pro Val Asn Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys 
        35                  40                  45              


Tyr Cys Asn Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg 
    50                  55                  60                  


Glu Lys Val Leu Ala Tyr Lys Ser Gln Pro Arg Lys Lys Glu Ser Leu 
65                  70                  75                  80  


Leu Thr Cys Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys 
                85                  90                  95      


Lys Val Gly Val Ile Pro Pro Lys Lys Phe Ile Thr Arg Leu Arg Lys 
            100                 105                 110         


Glu Asn Glu Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe 
        115                 120                 125             


Leu Asn Tyr Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Arg 
    130                 135                 140                 


Lys Gln Glu Lys Gln Asn Gly Arg Leu Pro Asn Gly Asn Ile Asp Asn 
145                 150                 155                 160 


Glu Asn Asn Asn Ser Thr Pro Asp Pro Thr Trp Val His Glu Ile Phe 
                165                 170                 175     


Gln Gly Thr Leu Thr Asn Glu Thr Arg Cys Leu Thr Cys Glu Thr Ile 
            180                 185                 190         


Ser Ser Lys Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln 
        195                 200                 205             


Asn Thr Ser Ile Thr His Cys Leu Arg Gly Phe Ser Asn Thr Glu Thr 
    210                 215                 220                 


Leu Cys Ser Glu Tyr Lys Tyr Tyr Cys Glu Glu Cys Arg Ser Lys Gln 
225                 230                 235                 240 


Glu Ala His Lys Arg Met Lys Val Lys Lys Leu Pro Met Ile Leu Ala 
                245                 250                 255     


Leu His Leu Lys Arg Phe Lys Tyr Met Asp Gln Leu His Arg Tyr Thr 
            260                 265                 270         


Lys Leu Ser Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn 
        275                 280                 285             


Thr Ser Gly Asp Ala Thr Asn Pro Asp Arg Met Tyr Asp Leu Val Ala 
    290                 295                 300                 


Val Val Val His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Ala 
305                 310                 315                 320 


Ile Val Lys Ser His Asp Phe Trp Leu Leu Phe Asp Asp Asp Ile Val 
                325                 330                 335     


Glu Lys Ile Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser 
            340                 345                 350         


Asp Ile Ser Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser 
        355                 360                 365             


Arg Asp 
    370 


<210> 65
<211> 530
<212> PRT
<213> Homo sapiens

<400> 65
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Asn Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr Leu Leu Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Lys Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 66
<211> 914
<212> PRT
<213> Homo sapiens

<400> 66
Met Gly Asp Ser Arg Asp Leu Cys Pro His Leu Asp Ser Ile Gly Glu 
1               5                   10                  15      


Val Thr Lys Glu Asp Leu Leu Leu Lys Ser Lys Gly Thr Cys Gln Ser 
            20                  25                  30          


Cys Gly Val Thr Gly Pro Asn Leu Trp Ala Cys Leu Gln Val Ala Cys 
        35                  40                  45              


Pro Tyr Val Gly Cys Gly Glu Ser Phe Ala Asp His Ser Thr Ile His 
    50                  55                  60                  


Ala Gln Ala Lys Lys His Asn Leu Thr Val Asn Leu Thr Thr Phe Arg 
65                  70                  75                  80  


Leu Trp Cys Tyr Ala Cys Glu Lys Glu Val Phe Leu Glu Gln Arg Leu 
                85                  90                  95      


Ala Ala Pro Leu Leu Gly Ser Ser Ser Lys Phe Ser Glu Gln Asp Ser 
            100                 105                 110         


Pro Pro Pro Ser His Pro Leu Lys Ala Val Pro Ile Ala Val Ala Asp 
        115                 120                 125             


Glu Gly Glu Ser Glu Ser Glu Asp Asp Asp Leu Lys Pro Arg Gly Leu 
    130                 135                 140                 


Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met Asn Ala Ala Leu 
145                 150                 155                 160 


Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe Phe Leu Glu Cys 
                165                 170                 175     


Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu Cys Lys Ser Tyr 
            180                 185                 190         


Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg Pro Ser Tyr Val 
        195                 200                 205             


Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val Asn Pro Met Phe 
    210                 215                 220                 


Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu Arg Cys Leu Met 
225                 230                 235                 240 


Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val Ala Thr Val Ala 
                245                 250                 255     


Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr Asp Glu Lys Arg 
            260                 265                 270         


Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu Ser Cys Asp Ser 
        275                 280                 285             


Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg Gly Gly Gly Ser 
    290                 295                 300                 


Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu Ala Gly Arg Ala 
305                 310                 315                 320 


Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe Ser Trp Gly Gln 
                325                 330                 335     


Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala Asp Val Asp Thr 
            340                 345                 350         


Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala Gln Pro Pro Ser 
        355                 360                 365             


Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro Asp Asn Asp Ala 
    370                 375                 380                 


His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val His His His Glu 
385                 390                 395                 400 


Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala Ser Pro Val Arg 
                405                 410                 415     


Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val Leu Ser Ala Gly 
            420                 425                 430         


Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val Ile Ser Asp Ile 
        435                 440                 445             


Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu Thr Cys Asp Arg 
    450                 455                 460                 


Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro 
465                 470                 475                 480 


Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile Tyr Gln Asn Val 
                485                 490                 495     


Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala Ala Gln Gly Trp 
            500                 505                 510         


Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val Val Ser Cys Thr 
        515                 520                 525             


Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu Asp Cys Leu Ala 
    530                 535                 540                 


Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys 
545                 550                 555                 560 


Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr Cys Lys Val Leu 
                565                 570                 575     


Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu 
            580                 585                 590         


Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser Phe Pro Leu Glu 
        595                 600                 605             


Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys Thr Ser Gln Ile 
    610                 615                 620                 


Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Gly 
625                 630                 635                 640 


Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile Asn Gly Gln Trp 
                645                 650                 655     


Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His Glu Thr Val Val 
            660                 665                 670         


Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu 
        675                 680                 685             


Ala Met Arg Glu Arg Gln Gln Val Val Ser Leu Ala Ala Met Arg Glu 
    690                 695                 700                 


Pro Ser Leu Leu Arg Phe Tyr Val Ser Arg Glu Trp Leu Asn Lys Phe 
705                 710                 715                 720 


Asn Thr Phe Ala Glu Pro Gly Pro Ile Thr Asn Gln Thr Phe Leu Cys 
                725                 730                 735     


Ser His Gly Gly Ile Pro Pro His Lys Tyr His Tyr Ile Asp Asp Leu 
            740                 745                 750         


Val Val Ile Leu Pro Gln Asn Val Trp Glu His Leu Tyr Asn Arg Phe 
        755                 760                 765             


Gly Gly Gly Pro Ala Val Asn His Leu Tyr Val Cys Ser Ile Cys Gln 
    770                 775                 780                 


Val Glu Ile Glu Ala Leu Ala Lys Arg Arg Arg Ile Glu Ile Asp Thr 
785                 790                 795                 800 


Phe Ile Lys Leu Asn Lys Ala Phe Gln Ala Glu Glu Ser Pro Gly Val 
                805                 810                 815     


Ile Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ala Phe Val 
            820                 825                 830         


Lys Gly Lys Asp Asn Glu Pro Pro Gly Pro Ile Asp Asn Ser Arg Ile 
        835                 840                 845             


Ala Gln Val Lys Gly Ser Gly His Val Gln Leu Lys Gln Gly Ala Asp 
    850                 855                 860                 


Tyr Gly Gln Ile Ser Glu Glu Thr Trp Thr Tyr Leu Asn Ser Leu Tyr 
865                 870                 875                 880 


Gly Gly Gly Pro Glu Ile Ala Ile Arg Gln Ser Val Ala Gln Pro Leu 
                885                 890                 895     


Gly Pro Glu Asn Leu His Gly Glu Gln Lys Ile Glu Ala Glu Thr Arg 
            900                 905                 910         


Ala Val 
        


<210> 67
<211> 366
<212> PRT
<213> Homo sapiens

<400> 67
Met Thr Val Arg Asn Ile Ala Ser Ile Cys Asn Met Gly Thr Asn Ala 
1               5                   10                  15      


Ser Ala Leu Glu Lys Asp Ile Gly Pro Glu Gln Phe Pro Ile Asn Glu 
            20                  25                  30          


His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn Ser 
        35                  40                  45              


Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Asn Val Leu 
    50                  55                  60                  


Ala Tyr Lys Ala Gln Gln Lys Lys Lys Glu Asn Leu Leu Thr Cys Leu 
65                  70                  75                  80  


Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly Val 
                85                  90                  95      


Ile Pro Pro Lys Lys Phe Ile Ser Arg Leu Arg Lys Glu Asn Asp Leu 
            100                 105                 110         


Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr Leu 
        115                 120                 125             


Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Lys Lys Gln Glu Lys 
    130                 135                 140                 


Gln Asn Gly Lys Leu Lys Asn Gly Asn Met Asn Glu Pro Ala Glu Asn 
145                 150                 155                 160 


Asn Lys Pro Glu Leu Thr Trp Val His Glu Ile Phe Gln Gly Thr Leu 
                165                 170                 175     


Thr Asn Glu Thr Arg Cys Leu Asn Cys Glu Thr Val Ser Ser Lys Asp 
            180                 185                 190         


Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser Ile 
        195                 200                 205             


Thr His Cys Leu Arg Asp Phe Ser Asn Thr Glu Thr Leu Cys Ser Glu 
    210                 215                 220                 


Gln Lys Tyr Tyr Cys Glu Thr Cys Cys Ser Lys Gln Glu Ala Gln Lys 
225                 230                 235                 240 


Arg Met Arg Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu Lys 
                245                 250                 255     


Arg Phe Lys Tyr Met Glu Gln Leu His Arg Tyr Thr Lys Leu Ser Tyr 
            260                 265                 270         


Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Ser Asp 
        275                 280                 285             


Ala Val Asn Leu Asp Arg Met Tyr Asp Leu Val Ala Val Val Val His 
    290                 295                 300                 


Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Thr Ile Val Lys Ser 
305                 310                 315                 320 


His Gly Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile Asp 
                325                 330                 335     


Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser Lys 
            340                 345                 350         


Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg Glu 
        355                 360                 365     


<210> 68
<211> 956
<212> PRT
<213> Homo sapiens

<400> 68
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Ala Leu Ser Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala 
305                 310                 315                 320 


Phe Met Ser Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys 
                325                 330                 335     


Pro Lys Ala Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser 
            340                 345                 350         


Glu Leu Phe Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln 
        355                 360                 365             


Ser Lys Ser Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro 
    370                 375                 380                 


Ala Lys Ser Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro 
385                 390                 395                 400 


Pro Leu Gln Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe 
                405                 410                 415     


His Ser Leu Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser 
            420                 425                 430         


Ile Gly His Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu 
        435                 440                 445             


Leu Asn Thr Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro 
    450                 455                 460                 


Gly Asn Ser His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu 
465                 470                 475                 480 


Asn Pro Pro Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly 
                485                 490                 495     


Leu Asn Glu Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly 
            500                 505                 510         


Cys Thr Asp Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu 
        515                 520                 525             


Lys Lys Ala Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg 
    530                 535                 540                 


Phe Ala Ser Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser 
545                 550                 555                 560 


Leu Ala Phe Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro 
                565                 570                 575     


Pro Lys Met Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys 
            580                 585                 590         


Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe 
        595                 600                 605             


Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro 
    610                 615                 620                 


Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu 
625                 630                 635                 640 


Arg Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala 
                645                 650                 655     


Thr Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala 
            660                 665                 670         


Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile 
        675                 680                 685             


Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser 
    690                 695                 700                 


Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu 
705                 710                 715                 720 


Lys Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp 
                725                 730                 735     


Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu 
            740                 745                 750         


Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys 
        755                 760                 765             


Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr 
    770                 775                 780                 


Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg 
785                 790                 795                 800 


Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe 
                805                 810                 815     


Cys Lys Thr Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn 
            820                 825                 830         


His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp 
        835                 840                 845             


Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val 
    850                 855                 860                 


Leu Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys 
865                 870                 875                 880 


Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly 
                885                 890                 895     


Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val 
            900                 905                 910         


Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser 
        915                 920                 925             


Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met 
    930                 935                 940                 


Cys Met Tyr Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950                 955     


<210> 69
<211> 823
<212> PRT
<213> Homo sapiens

<400> 69
Met Gly Lys Lys Arg Thr Lys Gly Lys Thr Val Pro Ile Asp Asp Ser 
1               5                   10                  15      


Ser Glu Thr Leu Glu Pro Val Cys Arg His Ile Arg Lys Gly Leu Glu 
            20                  25                  30          


Gln Gly Asn Leu Lys Lys Ala Leu Val Asn Val Glu Trp Asn Ile Cys 
        35                  40                  45              


Gln Asp Cys Lys Thr Asp Asn Lys Val Lys Asp Lys Ala Glu Glu Glu 
    50                  55                  60                  


Thr Glu Glu Lys Pro Ser Val Trp Leu Cys Leu Lys Cys Gly His Gln 
65                  70                  75                  80  


Gly Cys Gly Arg Asn Ser Gln Glu Gln His Ala Leu Lys His Tyr Leu 
                85                  90                  95      


Thr Pro Arg Ser Glu Pro His Cys Leu Val Leu Ser Leu Asp Asn Trp 
            100                 105                 110         


Ser Val Trp Cys Tyr Val Cys Asp Asn Glu Val Gln Tyr Cys Ser Ser 
        115                 120                 125             


Asn Gln Leu Gly Gln Val Val Asp Tyr Val Arg Lys Gln Ala Ser Ile 
    130                 135                 140                 


Thr Thr Pro Lys Pro Ala Glu Lys Asp Asn Gly Asn Ile Glu Leu Glu 
145                 150                 155                 160 


Asn Lys Lys Leu Glu Lys Glu Ser Lys Asn Glu Gln Glu Arg Glu Lys 
                165                 170                 175     


Lys Glu Asn Met Ala Lys Glu Asn Pro Pro Met Asn Ser Pro Cys Gln 
            180                 185                 190         


Ile Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn 
        195                 200                 205             


Ala Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu 
    210                 215                 220                 


Lys Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp 
225                 230                 235                 240 


Leu Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro 
                245                 250                 255     


Leu Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys 
            260                 265                 270         


Lys Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys 
        275                 280                 285             


Ala Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu 
    290                 295                 300                 


Arg Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser 
305                 310                 315                 320 


Lys Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu 
                325                 330                 335     


Glu Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro 
            340                 345                 350         


Ser Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met 
        355                 360                 365             


Cys Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp 
    370                 375                 380                 


Leu Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn 
385                 390                 395                 400 


Asp Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu 
                405                 410                 415     


Glu Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro 
            420                 425                 430         


Ser Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys 
        435                 440                 445             


Lys Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val 
    450                 455                 460                 


Leu His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu 
465                 470                 475                 480 


Tyr Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn 
                485                 490                 495     


His Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln 
            500                 505                 510         


Lys Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn 
        515                 520                 525             


Gln Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn 
    530                 535                 540                 


Asp Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala 
545                 550                 555                 560 


Tyr Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe 
                565                 570                 575     


Lys Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile 
            580                 585                 590         


Glu Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val 
        595                 600                 605             


Val Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu 
    610                 615                 620                 


Val Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe 
625                 630                 635                 640 


Thr Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val 
                645                 650                 655     


Cys Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu 
            660                 665                 670         


Arg Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu 
        675                 680                 685             


Ala Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly 
    690                 695                 700                 


Phe Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu 
705                 710                 715                 720 


Asp Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu 
                725                 730                 735     


Asn Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly 
            740                 745                 750         


Thr Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala 
        755                 760                 765             


Asn Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp 
    770                 775                 780                 


Phe Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His 
785                 790                 795                 800 


Val Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu 
                805                 810                 815     


Leu Phe Tyr Glu Arg Ile Leu 
            820             


<210> 70
<211> 1137
<212> PRT
<213> Homo sapiens

<400> 70
Met Lys Cys Val Phe Val Thr Val Gly Thr Thr Ser Phe Asp Asp Leu 
1               5                   10                  15      


Ile Ala Cys Val Ser Ala Pro Asp Ser Leu Gln Lys Ile Glu Ser Leu 
            20                  25                  30          


Gly Tyr Asn Arg Leu Ile Leu Gln Ile Gly Arg Gly Thr Val Val Pro 
        35                  40                  45              


Glu Pro Phe Ser Thr Glu Ser Phe Thr Leu Asp Val Tyr Arg Tyr Lys 
    50                  55                  60                  


Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu Val Ile Ser His 
65                  70                  75                  80  


Ala Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys Gly Lys Pro Leu 
                85                  90                  95      


Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His Gln Leu Glu Leu 
            100                 105                 110         


Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr Cys Thr Cys Arg 
        115                 120                 125             


Val Leu Thr Cys Pro Gly Gln Ala Lys Ser Ile Ala Ser Ala Pro Gly 
    130                 135                 140                 


Lys Cys Gln Asp Ser Ala Ala Leu Thr Ser Thr Ala Phe Ser Gly Leu 
145                 150                 155                 160 


Asp Phe Gly Leu Leu Ser Gly Tyr Leu His Lys Gln Ala Leu Val Thr 
                165                 170                 175     


Ala Thr His Pro Thr Cys Thr Leu Leu Phe Pro Ser Cys His Ala Phe 
            180                 185                 190         


Phe Pro Leu Pro Leu Thr Pro Thr Leu Tyr Lys Met His Lys Gly Trp 
        195                 200                 205             


Lys Asn Tyr Cys Ser Gln Lys Ser Leu Asn Glu Ala Ser Met Asp Glu 
    210                 215                 220                 


Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr Ala Lys Asp Ala 
225                 230                 235                 240 


Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe Cys Ser Gln Val 
                245                 250                 255     


His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr Met Arg Glu Asn 
            260                 265                 270         


Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe Glu Lys Tyr Leu 
        275                 280                 285             


Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln Leu Glu Ile Arg 
    290                 295                 300                 


Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu Tyr Arg Phe Pro 
305                 310                 315                 320 


Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr Glu Asp Lys Ile 
                325                 330                 335     


Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser Val Tyr Ser Lys 
            340                 345                 350         


Gln Phe Gln Ser Ser Ala Ala Val Cys Gln Ala Val Leu Tyr Glu Ile 
        355                 360                 365             


Leu Tyr Lys Asp Val Phe Val Val Asp Glu Glu Glu Leu Lys Thr Ala 
    370                 375                 380                 


Ile Lys Leu Phe Arg Ser Gly Ser Lys Lys Asn Arg Asn Asn Ala Val 
385                 390                 395                 400 


Thr Gly Ser Glu Asp Ala His Thr Asp Tyr Lys Ser Ser Asn Gln Asn 
                405                 410                 415     


Arg Met Glu Glu Trp Gly Ala Cys Tyr Asn Ala Glu Asn Ile Pro Glu 
            420                 425                 430         


Gly Tyr Asn Lys Gly Thr Glu Glu Thr Lys Ser Pro Glu Asn Pro Ser 
        435                 440                 445             


Lys Met Pro Phe Pro Tyr Lys Val Leu Lys Ala Leu Asp Pro Glu Ile 
    450                 455                 460                 


Tyr Arg Asn Val Glu Phe Asp Val Trp Leu Asp Ser Arg Lys Glu Leu 
465                 470                 475                 480 


Gln Lys Ser Asp Tyr Met Glu Tyr Ala Gly Arg Gln Tyr Tyr Leu Gly 
                485                 490                 495     


Asp Lys Cys Gln Val Cys Leu Glu Ser Glu Gly Arg Tyr Tyr Asn Ala 
            500                 505                 510         


His Ile Gln Glu Val Gly Asn Glu Asn Asn Ser Val Thr Val Phe Ile 
        515                 520                 525             


Glu Glu Leu Ala Glu Lys His Val Val Pro Leu Ala Asn Leu Lys Pro 
    530                 535                 540                 


Val Thr Gln Val Met Ser Val Pro Ala Trp Asn Ala Met Pro Ser Arg 
545                 550                 555                 560 


Lys Gly Arg Gly Tyr Gln Lys Met Pro Gly Gly Tyr Val Pro Glu Ile 
                565                 570                 575     


Val Ile Ser Glu Met Asp Ile Lys Gln Gln Lys Lys Met Phe Lys Lys 
            580                 585                 590         


Ile Arg Gly Lys Glu Val Tyr Met Thr Met Ala Tyr Gly Lys Gly Asp 
        595                 600                 605             


Pro Leu Leu Pro Pro Arg Leu Gln His Ser Met His Tyr Gly His Asp 
    610                 615                 620                 


Pro Pro Met His Tyr Ser Gln Thr Ala Gly Asn Val Met Ser Asn Glu 
625                 630                 635                 640 


His Phe His Pro Gln His Pro Ser Pro Arg Gln Gly Arg Gly Tyr Gly 
                645                 650                 655     


Met Pro Arg Asn Ser Ser Arg Phe Ile Asn Arg His Asn Met Pro Gly 
            660                 665                 670         


Pro Lys Val Asp Phe Tyr Pro Gly Pro Gly Lys Arg Cys Cys Gln Ser 
        675                 680                 685             


Tyr Asp Asn Phe Ser Tyr Arg Ser Arg Ser Phe Arg Arg Ser His Arg 
    690                 695                 700                 


Gln Met Ser Cys Val Asn Lys Glu Ser Gln Tyr Gly Phe Thr Pro Gly 
705                 710                 715                 720 


Asn Gly Gln Met Pro Arg Gly Leu Glu Glu Thr Ile Thr Phe Tyr Glu 
                725                 730                 735     


Val Glu Glu Gly Asp Glu Thr Ala Tyr Pro Thr Leu Pro Asn His Gly 
            740                 745                 750         


Gly Pro Ser Thr Met Val Pro Ala Thr Ser Gly Tyr Cys Val Gly Arg 
        755                 760                 765             


Arg Gly His Ser Ser Gly Lys Gln Thr Leu Asn Leu Glu Glu Gly Asn 
    770                 775                 780                 


Gly Gln Ser Glu Asn Gly Arg Tyr His Glu Glu Tyr Leu Tyr Arg Ala 
785                 790                 795                 800 


Glu Pro Asp Tyr Glu Thr Ser Gly Val Tyr Ser Thr Thr Ala Ser Thr 
                805                 810                 815     


Ala Asn Leu Ser Leu Gln Asp Arg Lys Ser Cys Ser Met Ser Pro Gln 
            820                 825                 830         


Asp Thr Val Thr Ser Tyr Asn Tyr Pro Gln Lys Met Met Gly Asn Ile 
        835                 840                 845             


Ala Ala Val Ala Ala Ser Cys Ala Asn Asn Val Pro Ala Pro Val Leu 
    850                 855                 860                 


Ser Asn Gly Ala Ala Ala Asn Gln Ala Ile Ser Thr Thr Ser Val Ser 
865                 870                 875                 880 


Ser Gln Asn Ala Ile Gln Pro Leu Phe Val Ser Pro Pro Thr His Gly 
                885                 890                 895     


Arg Pro Val Ile Ala Ser Pro Ser Tyr Pro Cys His Ser Ala Ile Pro 
            900                 905                 910         


His Ala Gly Ala Ser Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    930                 935                 940                 


Pro Ala Leu Asp Val Gly Glu Thr Ser Asn Leu Gln Pro Pro Pro Pro 
945                 950                 955                 960 


Leu Pro Pro Pro Pro Tyr Ser Cys Asp Pro Ser Gly Ser Asp Leu Pro 
                965                 970                 975     


Gln Asp Thr Lys Val Leu Gln Tyr Tyr Phe Asn Leu Gly Leu Gln Cys 
            980                 985                 990         


Tyr Tyr His Ser Tyr Trp His Ser  Met Val Tyr Val Pro  Gln Met Gln 
        995                 1000                 1005             


Gln Gln  Leu His Val Glu Asn  Tyr Pro Val Tyr Thr  Glu Pro Pro 
    1010                 1015                 1020             


Leu Val  Asp Gln Thr Val Pro  Gln Cys Tyr Ser Glu  Val Arg Arg 
    1025                 1030                 1035             


Glu Asp  Gly Ile Gln Ala Glu  Ala Ser Ala Asn Asp  Thr Phe Pro 
    1040                 1045                 1050             


Asn Ala  Asp Ser Ser Ser Val  Pro His Gly Ala Val  Tyr Tyr Pro 
    1055                 1060                 1065             


Val Met  Ser Asp Pro Tyr Gly  Gln Pro Pro Leu Pro  Gly Phe Asp 
    1070                 1075                 1080             


Ser Cys  Leu Pro Val Val Pro  Asp Tyr Ser Cys Val  Pro Pro Trp 
    1085                 1090                 1095             


His Pro  Val Gly Thr Ala Tyr  Gly Gly Ser Ser Gln  Ile His Gly 
    1100                 1105                 1110             


Ala Ile  Asn Pro Gly Pro Ile  Gly Cys Ile Ala Pro  Ser Pro Pro 
    1115                 1120                 1125             


Ala Ser  His Tyr Val Pro Gln  Gly Met 
    1130                 1135         


<210> 71
<211> 348
<212> PRT
<213> Homo sapiens

<400> 71
Met Phe Gly Pro Ala Lys Gly Arg His Phe Gly Val His Pro Ala Pro 
1               5                   10                  15      


Gly Phe Pro Gly Gly Val Ser Gln Gln Ala Ala Gly Thr Lys Ala Gly 
            20                  25                  30          


Pro Ala Gly Ala Trp Pro Val Gly Ser Arg Thr Asp Thr Met Trp Arg 
        35                  40                  45              


Leu Arg Cys Lys Ala Lys Asp Gly Thr His Val Leu Gln Gly Leu Ser 
    50                  55                  60                  


Ser Arg Thr Arg Val Arg Glu Leu Gln Gly Gln Ile Ala Ala Ile Thr 
65                  70                  75                  80  


Gly Ile Ala Pro Gly Gly Gln Arg Ile Leu Val Gly Tyr Pro Pro Glu 
                85                  90                  95      


Cys Leu Asp Leu Ser Asn Gly Asp Thr Ile Leu Glu Asp Leu Pro Ile 
            100                 105                 110         


Gln Ser Gly Asp Met Leu Ile Ile Glu Glu Asp Gln Thr Arg Pro Arg 
        115                 120                 125             


Ser Ser Pro Ala Phe Thr Lys Arg Gly Ala Ser Ser Tyr Val Arg Glu 
    130                 135                 140                 


Thr Leu Pro Val Leu Thr Arg Thr Val Val Pro Ala Asp Asn Ser Cys 
145                 150                 155                 160 


Leu Phe Thr Ser Val Tyr Tyr Val Val Glu Gly Gly Val Leu Asn Pro 
                165                 170                 175     


Ala Cys Ala Pro Glu Met Arg Arg Leu Ile Ala Gln Ile Val Ala Ser 
            180                 185                 190         


Asp Pro Asp Phe Tyr Ser Glu Ala Ile Leu Gly Lys Thr Asn Gln Glu 
        195                 200                 205             


Tyr Cys Asp Trp Ile Lys Arg Asp Asp Thr Trp Gly Gly Ala Ile Glu 
    210                 215                 220                 


Ile Ser Ile Leu Ser Lys Phe Tyr Gln Cys Glu Ile Cys Val Val Asp 
225                 230                 235                 240 


Thr Gln Thr Val Arg Ile Asp Arg Phe Gly Glu Asp Ala Gly Tyr Thr 
                245                 250                 255     


Lys Arg Val Leu Leu Ile Tyr Asp Gly Ile His Tyr Asp Pro Leu Gln 
            260                 265                 270         


Arg Asn Phe Pro Asp Pro Asp Thr Pro Pro Leu Thr Ile Phe Ser Ser 
        275                 280                 285             


Asn Asp Asp Ile Val Leu Val Gln Ala Leu Glu Leu Ala Asp Glu Ala 
    290                 295                 300                 


Arg Arg Arg Arg Gln Phe Thr Asp Val Asn Arg Phe Thr Leu Arg Cys 
305                 310                 315                 320 


Met Val Cys Gln Lys Gly Leu Thr Gly Gln Ala Glu Ala Arg Glu His 
                325                 330                 335     


Ala Lys Glu Thr Gly His Thr Asn Phe Gly Glu Val 
            340                 345             


<210> 72
<211> 481
<212> PRT
<213> Homo sapiens

<400> 72
Met Gln Leu Tyr Ser Ser Val Cys Thr His Tyr Pro Ala Gly Ala Pro 
1               5                   10                  15      


Gly Pro Thr Ala Ala Ala Pro Ala Pro Pro Ala Ala Ala Thr Pro Phe 
            20                  25                  30          


Lys Val Ser Leu Gln Pro Pro Gly Ala Ala Gly Ala Ala Pro Glu Pro 
        35                  40                  45              


Glu Thr Gly Glu Cys Gln Pro Ala Ala Ala Ala Glu His Arg Glu Ala 
    50                  55                  60                  


Ala Ala Val Pro Ala Ala Lys Met Pro Ala Phe Ser Ser Cys Phe Glu 
65                  70                  75                  80  


Val Val Ser Gly Ala Ala Ala Pro Ala Ser Ala Ala Ala Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Cys Lys Pro Pro Leu Pro Pro His Tyr Thr Ser Thr Ala 
            100                 105                 110         


Gln Ile Thr Val Arg Ala Leu Gly Ala Asp Arg Leu Leu Leu His Gly 
        115                 120                 125             


Pro Asp Pro Val Pro Gly Ala Ala Gly Ser Ala Ala Ala Pro Arg Gly 
    130                 135                 140                 


Arg Cys Leu Leu Leu Ala Pro Ala Pro Ala Ala Pro Val Pro Pro Arg 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Trp Leu Leu Glu Glu Leu Leu Arg Pro Asp Cys 
                165                 170                 175     


Pro Glu Pro Ala Gly Leu Asp Ala Thr Arg Glu Gly Pro Asp Arg Asn 
            180                 185                 190         


Phe Arg Leu Ser Glu His Arg Gln Ala Leu Ala Ala Ala Lys His Arg 
        195                 200                 205             


Gly Pro Ala Ala Thr Pro Gly Ser Pro Asp Pro Gly Pro Gly Pro Trp 
    210                 215                 220                 


Gly Glu Glu His Leu Ala Glu Arg Gly Pro Arg Gly Trp Glu Arg Gly 
225                 230                 235                 240 


Gly Asp Arg Cys Asp Ala Pro Gly Gly Asp Ala Ala Arg Arg Pro Asp 
                245                 250                 255     


Pro Glu Ala Glu Ala Pro Pro Ala Gly Ser Ile Glu Ala Ala Pro Ser 
            260                 265                 270         


Ser Ala Ala Glu Pro Val Ile Val Ser Arg Ser Asp Pro Arg Asp Glu 
        275                 280                 285             


Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln Asp Lys Tyr Leu 
    290                 295                 300                 


Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro Asp Gly Asn Cys 
305                 310                 315                 320 


Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp Gln Ser Leu His 
                325                 330                 335     


Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala Asp His Leu Asp 
            340                 345                 350         


His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu Phe Ile Ile Ala 
        355                 360                 365             


Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu Leu Leu Ala Met 
    370                 375                 380                 


Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr Gly Gly Arg Leu 
385                 390                 395                 400 


Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu Gly Pro Glu Asp 
                405                 410                 415     


Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser Asn Gly His Tyr 
            420                 425                 430         


Asp Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu Tyr Asp Asn Trp 
        435                 440                 445             


Cys Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu Glu Leu Ala Lys 
    450                 455                 460                 


Ser Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu Gln Asn Ala Cys 
465                 470                 475                 480 


Ser 
    


<210> 73
<211> 293
<212> PRT
<213> Homo sapiens

<400> 73
Met Glu Ala Val Leu Thr Glu Glu Leu Asp Glu Glu Glu Gln Leu Leu 
1               5                   10                  15      


Arg Arg His Arg Lys Glu Lys Lys Glu Leu Gln Ala Lys Ile Gln Gly 
            20                  25                  30          


Met Lys Asn Ala Val Pro Lys Asn Asp Lys Lys Arg Arg Lys Gln Leu 
        35                  40                  45              


Thr Glu Asp Val Ala Lys Leu Glu Lys Glu Met Glu Gln Lys His Arg 
    50                  55                  60                  


Glu Glu Leu Glu Gln Leu Lys Leu Thr Thr Lys Glu Asn Lys Ile Asp 
65                  70                  75                  80  


Ser Val Ala Val Asn Ile Ser Asn Leu Val Leu Glu Asn Gln Pro Pro 
                85                  90                  95      


Arg Ile Ser Lys Ala Gln Lys Arg Arg Glu Lys Lys Ala Ala Leu Glu 
            100                 105                 110         


Lys Glu Arg Glu Glu Arg Ile Ala Glu Ala Glu Ile Glu Asn Leu Thr 
        115                 120                 125             


Gly Ala Arg His Met Glu Ser Glu Lys Leu Ala Gln Ile Leu Ala Ala 
    130                 135                 140                 


Arg Gln Leu Glu Ile Lys Gln Ile Pro Ser Asp Gly His Cys Met Tyr 
145                 150                 155                 160 


Lys Ala Ile Glu Asp Gln Leu Lys Glu Lys Asp Cys Ala Leu Thr Val 
                165                 170                 175     


Val Ala Leu Arg Ser Gln Thr Ala Glu Tyr Met Gln Ser His Val Glu 
            180                 185                 190         


Asp Phe Leu Pro Phe Leu Thr Asn Pro Asn Thr Gly Asp Met Tyr Thr 
        195                 200                 205             


Pro Glu Glu Phe Gln Lys Tyr Cys Glu Asp Ile Val Asn Thr Ala Ala 
    210                 215                 220                 


Trp Gly Gly Gln Leu Glu Leu Arg Ala Leu Ser His Ile Leu Gln Thr 
225                 230                 235                 240 


Pro Ile Glu Ile Ile Gln Ala Asp Ser Pro Pro Ile Ile Val Gly Glu 
                245                 250                 255     


Glu Tyr Ser Lys Lys Pro Leu Ile Leu Val Tyr Met Arg His Ala Tyr 
            260                 265                 270         


Gly Leu Gly Glu His Tyr Asn Ser Val Thr Arg Leu Val Asn Ile Val 
        275                 280                 285             


Thr Glu Asn Cys Ser 
    290             


<210> 74
<211> 288
<212> PRT
<213> Homo sapiens

<400> 74
Met Asp Asp Pro Lys Ser Glu Gln Gln Arg Ile Leu Arg Arg His Gln 
1               5                   10                  15      


Arg Glu Arg Gln Glu Leu Gln Ala Gln Ile Arg Ser Leu Lys Asn Ser 
            20                  25                  30          


Val Pro Lys Thr Asp Lys Thr Lys Arg Lys Gln Leu Leu Gln Asp Val 
        35                  40                  45              


Ala Arg Met Glu Ala Glu Met Ala Gln Lys His Arg Gln Glu Leu Glu 
    50                  55                  60                  


Lys Phe Gln Asp Asp Ser Ser Ile Glu Ser Val Val Glu Asp Leu Ala 
65                  70                  75                  80  


Lys Met Asn Leu Glu Asn Arg Pro Pro Arg Ser Ser Lys Ala His Arg 
                85                  90                  95      


Lys Arg Glu Arg Met Glu Ser Glu Glu Arg Glu Arg Gln Glu Ser Ile 
            100                 105                 110         


Phe Gln Ala Glu Met Ser Glu His Leu Ala Gly Phe Lys Arg Glu Glu 
        115                 120                 125             


Glu Glu Lys Leu Ala Ala Ile Leu Gly Ala Arg Gly Leu Glu Met Lys 
    130                 135                 140                 


Ala Ile Pro Ala Asp Gly His Cys Met Tyr Arg Ala Ile Gln Asp Gln 
145                 150                 155                 160 


Leu Val Phe Ser Val Ser Val Glu Met Leu Arg Cys Arg Thr Ala Ser 
                165                 170                 175     


Tyr Met Lys Lys His Val Asp Glu Phe Leu Pro Phe Phe Ser Asn Pro 
            180                 185                 190         


Glu Thr Ser Asp Ser Phe Gly Tyr Asp Asp Phe Met Ile Tyr Cys Asp 
        195                 200                 205             


Asn Ile Val Arg Thr Thr Ala Trp Gly Gly Gln Leu Glu Leu Arg Ala 
    210                 215                 220                 


Leu Ser His Val Leu Lys Thr Pro Ile Glu Val Ile Gln Ala Asp Ser 
225                 230                 235                 240 


Pro Thr Leu Ile Ile Gly Glu Glu Tyr Val Lys Lys Pro Ile Ile Leu 
                245                 250                 255     


Val Tyr Leu Arg Tyr Ala Tyr Ser Leu Gly Glu His Tyr Asn Ser Val 
            260                 265                 270         


Thr Pro Leu Glu Ala Gly Ala Ala Gly Gly Val Leu Pro Arg Leu Leu 
        275                 280                 285             


<210> 75
<211> 271
<212> PRT
<213> Homo sapiens

<400> 75
Met Ala Ala Glu Glu Pro Gln Gln Gln Lys Gln Glu Pro Leu Gly Ser 
1               5                   10                  15      


Asp Ser Glu Gly Val Asn Cys Leu Ala Tyr Asp Glu Ala Ile Met Ala 
            20                  25                  30          


Gln Gln Asp Arg Ile Gln Gln Glu Ile Ala Val Gln Asn Pro Leu Val 
        35                  40                  45              


Ser Glu Arg Leu Glu Leu Ser Val Leu Tyr Lys Glu Tyr Ala Glu Asp 
    50                  55                  60                  


Asp Asn Ile Tyr Gln Gln Lys Ile Lys Asp Leu His Lys Lys Tyr Ser 
65                  70                  75                  80  


Tyr Ile Arg Lys Thr Arg Pro Asp Gly Asn Cys Phe Tyr Arg Ala Phe 
                85                  90                  95      


Gly Phe Ser His Leu Glu Ala Leu Leu Asp Asp Ser Lys Glu Leu Gln 
            100                 105                 110         


Arg Phe Lys Ala Val Ser Ala Lys Ser Lys Glu Asp Leu Val Ser Gln 
        115                 120                 125             


Gly Phe Thr Glu Phe Thr Ile Glu Asp Phe His Asn Thr Phe Met Asp 
    130                 135                 140                 


Leu Ile Glu Gln Val Glu Lys Gln Thr Ser Val Ala Asp Leu Leu Ala 
145                 150                 155                 160 


Ser Phe Asn Asp Gln Ser Thr Ser Asp Tyr Leu Val Val Tyr Leu Arg 
                165                 170                 175     


Leu Leu Thr Ser Gly Tyr Leu Gln Arg Glu Ser Lys Phe Phe Glu His 
            180                 185                 190         


Phe Ile Glu Gly Gly Arg Thr Val Lys Glu Phe Cys Gln Gln Glu Val 
        195                 200                 205             


Glu Pro Met Cys Lys Glu Ser Asp His Ile His Ile Ile Ala Leu Ala 
    210                 215                 220                 


Gln Ala Leu Ser Val Ser Ile Gln Val Glu Tyr Met Asp Arg Gly Glu 
225                 230                 235                 240 


Gly Gly Thr Thr Asn Pro His Ile Phe Pro Glu Gly Ser Glu Pro Lys 
                245                 250                 255     


Val Tyr Leu Leu Tyr Arg Pro Gly His Tyr Asp Ile Leu Tyr Lys 
            260                 265                 270     


<210> 76
<211> 926
<212> PRT
<213> Homo sapiens

<400> 76
Met Val Ser Ser Val Leu Pro Asn Pro Thr Ser Ala Glu Cys Trp Ala 
1               5                   10                  15      


Ala Leu Leu His Asp Pro Met Thr Leu Asp Met Asp Ala Val Leu Ser 
            20                  25                  30          


Asp Phe Val Arg Ser Thr Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu 
        35                  40                  45              


Leu Glu Gly Lys Asn Trp Asp Leu Thr Ala Ala Leu Ser Asp Tyr Glu 
    50                  55                  60                  


Gln Leu Arg Gln Val His Thr Ala Asn Leu Pro His Val Phe Asn Glu 
65                  70                  75                  80  


Gly Arg Gly Pro Lys Gln Pro Glu Arg Glu Pro Gln Pro Gly His Lys 
                85                  90                  95      


Val Glu Arg Pro Cys Leu Gln Arg Gln Asp Asp Ile Ala Gln Glu Lys 
            100                 105                 110         


Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ala Ile Val Ser Leu 
        115                 120                 125             


Ala Arg Ser His Val Ala Ser Glu Cys Asn Asn Glu Gln Phe Pro Leu 
    130                 135                 140                 


Glu Met Pro Ile Tyr Thr Phe Gln Leu Pro Asp Leu Ser Val Tyr Ser 
145                 150                 155                 160 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ala Thr 
                165                 170                 175     


Met Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Ser Thr Val 
            180                 185                 190         


Cys Thr Ser Cys Lys Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
        195                 200                 205             


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
    210                 215                 220                 


Arg Asp Leu Val Leu Arg Lys Ala Leu Tyr Thr Met Met Arg Thr Gly 
225                 230                 235                 240 


Ala Glu Arg Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
                245                 250                 255     


Gln Asn Lys Glu Glu Glu Trp Glu Arg Glu Trp Thr Glu Leu Leu Lys 
            260                 265                 270         


Leu Ala Ser Ser Glu Pro Arg Thr His Phe Ser Lys Asn Gly Gly Thr 
        275                 280                 285             


Gly Gly Gly Val Asp Asn Ser Glu Asp Pro Val Tyr Glu Ser Leu Glu 
    290                 295                 300                 


Glu Phe His Val Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Val 
305                 310                 315                 320 


Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala 
                325                 330                 335     


Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Pro Asn 
            340                 345                 350         


Arg Cys His Cys Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe 
        355                 360                 365             


Ser Ala Leu Val Ser Met Glu Gln Arg Asp Gln Gln Arg Glu Gln Ala 
    370                 375                 380                 


Val Ile Pro Leu Thr Asp Ser Glu His Lys Leu Leu Pro Leu His Phe 
385                 390                 395                 400 


Ala Val Asp Pro Gly Lys Asp Trp Glu Trp Gly Lys Asp Asp Asn Asp 
                405                 410                 415     


Asn Ala Arg Leu Ala His Leu Ile Leu Ser Leu Glu Ala Lys Leu Asn 
            420                 425                 430         


Leu Leu His Ser Tyr Met Asn Val Thr Trp Ile Arg Ile Pro Ser Glu 
        435                 440                 445             


Thr Arg Ala Pro Leu Ala Gln Pro Glu Ser Pro Thr Ala Ser Ala Gly 
    450                 455                 460                 


Glu Asp Val Gln Ser Leu Ala Asp Ser Leu Asp Ser Asp Arg Asp Ser 
465                 470                 475                 480 


Val Cys Ser Asn Ser Asn Ser Asn Asn Gly Lys Asn Gly Lys Asp Lys 
                485                 490                 495     


Glu Lys Glu Lys Gln Arg Lys Glu Lys Asp Lys Thr Arg Ala Asp Ser 
            500                 505                 510         


Val Ala Asn Lys Leu Gly Ser Phe Ser Lys Thr Leu Gly Ile Lys Leu 
        515                 520                 525             


Lys Lys Asn Met Gly Gly Leu Gly Gly Leu Val His Gly Lys Met Gly 
    530                 535                 540                 


Arg Ala Asn Ser Ala Asn Gly Lys Asn Gly Asp Ser Ala Glu Arg Gly 
545                 550                 555                 560 


Lys Glu Lys Lys Ala Lys Ser Arg Lys Gly Ser Lys Glu Glu Ser Gly 
                565                 570                 575     


Ala Ser Ala Ser Thr Ser Pro Ser Glu Lys Thr Thr Pro Ser Pro Thr 
            580                 585                 590         


Asp Lys Ala Ala Gly Ala Ser Pro Ala Glu Lys Gly Gly Gly Pro Arg 
        595                 600                 605             


Gly Asp Ala Trp Lys Tyr Ser Thr Asp Val Lys Leu Ser Leu Asn Ile 
    610                 615                 620                 


Leu Arg Ala Ala Met Gln Gly Glu Arg Lys Phe Ile Phe Ala Gly Leu 
625                 630                 635                 640 


Leu Leu Thr Ser His Arg His Gln Phe His Glu Glu Met Ile Gly Tyr 
                645                 650                 655     


Tyr Leu Thr Ser Ala Gln Glu Arg Phe Ser Ala Glu Gln Glu Gln Arg 
            660                 665                 670         


Arg Arg Asp Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        675                 680                 685             


Ala Thr Ala Lys Arg Pro Pro Arg Arg Pro Glu Thr Glu Gly Val Pro 
    690                 695                 700                 


Val Pro Glu Arg Ala Ser Pro Gly Pro Pro Thr Gln Leu Val Leu Lys 
705                 710                 715                 720 


Leu Lys Glu Arg Pro Ser Pro Gly Pro Ala Ala Gly Arg Ala Ala Arg 
                725                 730                 735     


Ala Ala Ala Gly Gly Thr Ala Ser Pro Gly Gly Gly Ala Arg Arg Ala 
            740                 745                 750         


Ser Ala Ser Gly Pro Val Pro Gly Arg Ser Pro Pro Ala Pro Ala Arg 
        755                 760                 765             


Gln Ser Val Ile His Val Gln Ala Ser Gly Ala Arg Asp Glu Ala Cys 
    770                 775                 780                 


Ala Pro Ala Val Gly Ala Leu Arg Pro Cys Ala Thr Tyr Pro Gln Gln 
785                 790                 795                 800 


Asn Arg Ser Leu Ser Ser Gln Ser Tyr Ser Pro Ala Arg Ala Ala Ala 
                805                 810                 815     


Leu Arg Thr Val Asn Thr Val Glu Ser Leu Ala Arg Ala Val Pro Gly 
            820                 825                 830         


Ala Leu Pro Gly Ala Ala Gly Thr Ala Gly Ala Ala Glu His Lys Ser 
        835                 840                 845             


Gln Thr Tyr Thr Asn Gly Phe Gly Ala Leu Arg Asp Gly Leu Glu Phe 
    850                 855                 860                 


Ala Asp Ala Asp Ala Pro Thr Ala Arg Ser Asn Gly Glu Cys Gly Arg 
865                 870                 875                 880 


Gly Gly Pro Gly Pro Val Gln Arg Arg Cys Gln Arg Glu Asn Cys Ala 
                885                 890                 895     


Phe Tyr Gly Arg Ala Glu Thr Glu His Tyr Cys Ser Tyr Cys Tyr Arg 
            900                 905                 910         


Glu Glu Leu Arg Arg Arg Arg Glu Ala Arg Gly Ala Arg Pro 
        915                 920                 925     


<210> 77
<211> 1113
<212> PRT
<213> Homo sapiens

<400> 77
Met Glu Ala Ala Val Gly Val Pro Asp Gly Gly Asp Gln Gly Gly Ala 
1               5                   10                  15      


Gly Pro Arg Glu Asp Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            20                  25                  30          


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        35                  40                  45              


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    50                  55                  60                  


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
65                  70                  75                  80  


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                85                  90                  95      


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            100                 105                 110         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        115                 120                 125             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    130                 135                 140                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser 
145                 150                 155                 160 


Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val 
                165                 170                 175     


Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu 
            180                 185                 190         


Val Ala Asp Glu Asp Asn Ser Glu Ile Ser Asp Ser Glu Asp Asp Ser 
        195                 200                 205             


Cys Lys Ser Lys Thr Ala Ala Ala Ala Ala Asp Val Asn Gly Phe Lys 
    210                 215                 220                 


Pro Leu Ser Gly Asn Glu Gln Leu Lys Asn Asn Gly Asn Ser Thr Ser 
225                 230                 235                 240 


Leu Pro Leu Ser Arg Lys Val Leu Lys Ser Leu Asn Pro Ala Val Tyr 
                245                 250                 255     


Arg Asn Val Glu Tyr Glu Ile Trp Leu Lys Ser Lys Gln Ala Gln Gln 
            260                 265                 270         


Lys Arg Asp Tyr Ser Ile Ala Ala Gly Leu Gln Tyr Glu Val Gly Asp 
        275                 280                 285             


Lys Cys Gln Val Arg Leu Asp His Asn Gly Lys Phe Leu Asn Ala Asp 
    290                 295                 300                 


Val Gln Gly Ile His Ser Glu Asn Gly Pro Val Leu Val Glu Glu Leu 
305                 310                 315                 320 


Gly Lys Lys His Thr Ser Lys Asn Leu Lys Ala Pro Pro Pro Glu Ser 
                325                 330                 335     


Trp Asn Thr Val Ser Gly Lys Lys Met Lys Lys Pro Ser Thr Ser Gly 
            340                 345                 350         


Gln Asn Phe His Ser Asp Val Asp Tyr Arg Gly Pro Lys Asn Pro Ser 
        355                 360                 365             


Lys Pro Ile Lys Ala Pro Ser Ala Leu Pro Pro Arg Leu Gln His Pro 
    370                 375                 380                 


Ser Gly Val Arg Gln His Ala Phe Ser Ser His Ser Ser Gly Ser Gln 
385                 390                 395                 400 


Ser Gln Lys Phe Ser Ser Glu His Lys Asn Leu Ser Arg Thr Pro Ser 
                405                 410                 415     


Gln Ile Ile Arg Lys Pro Asp Arg Glu Arg Val Glu Asp Phe Asp His 
            420                 425                 430         


Thr Ser Arg Glu Ser Asn Tyr Phe Gly Leu Ser Pro Glu Glu Arg Arg 
        435                 440                 445             


Glu Lys Gln Ala Ile Glu Glu Ser Arg Leu Leu Tyr Glu Ile Gln Asn 
    450                 455                 460                 


Arg Asp Glu Gln Ala Phe Pro Ala Leu Ser Ser Ser Ser Val Asn Gln 
465                 470                 475                 480 


Ser Ala Ser Gln Ser Ser Asn Pro Cys Val Gln Arg Lys Ser Ser His 
                485                 490                 495     


Val Gly Asp Arg Lys Gly Ser Arg Arg Arg Met Asp Thr Glu Glu Arg 
            500                 505                 510         


Lys Asp Lys Asp Ser Ile His Gly His Ser Gln Leu Asp Lys Arg Pro 
        515                 520                 525             


Glu Pro Ser Thr Leu Glu Asn Ile Thr Asp Asp Lys Tyr Ala Thr Val 
    530                 535                 540                 


Ser Ser Pro Ser Lys Ser Lys Lys Leu Glu Cys Pro Ser Pro Ala Glu 
545                 550                 555                 560 


Gln Lys Pro Ala Glu His Val Ser Leu Ser Asn Pro Ala Pro Leu Leu 
                565                 570                 575     


Val Ser Pro Glu Val His Leu Thr Pro Ala Val Pro Ser Leu Pro Ala 
            580                 585                 590         


Thr Val Pro Ala Trp Pro Ser Glu Pro Thr Thr Phe Gly Pro Thr Gly 
        595                 600                 605             


Val Pro Ala Pro Ile Pro Val Leu Ser Val Thr Gln Thr Leu Thr Thr 
    610                 615                 620                 


Gly Pro Asp Ser Ala Val Ser Gln Ala His Leu Thr Pro Ser Pro Val 
625                 630                 635                 640 


Pro Val Ser Ile Gln Ala Val Asn Gln Pro Leu Met Pro Leu Pro Gln 
                645                 650                 655     


Thr Leu Ser Leu Tyr Gln Asp Pro Leu Tyr Pro Gly Phe Pro Cys Asn 
            660                 665                 670         


Glu Lys Gly Asp Arg Ala Ile Val Pro Pro Tyr Ser Leu Cys Gln Thr 
        675                 680                 685             


Gly Glu Asp Leu Pro Lys Asp Lys Asn Ile Leu Arg Phe Phe Phe Asn 
    690                 695                 700                 


Leu Gly Val Lys Ala Tyr Ser Cys Pro Met Trp Ala Pro His Ser Tyr 
705                 710                 715                 720 


Leu Tyr Pro Leu His Gln Ala Tyr Leu Ala Ala Cys Arg Met Tyr Pro 
                725                 730                 735     


Lys Val Pro Val Pro Val Tyr Pro His Asn Pro Trp Phe Gln Glu Ala 
            740                 745                 750         


Pro Ala Ala Gln Asn Glu Ser Asp Cys Thr Cys Thr Asp Ala His Phe 
        755                 760                 765             


Pro Met Gln Thr Glu Ala Ser Val Asn Gly Gln Met Pro Gln Pro Glu 
    770                 775                 780                 


Ile Gly Pro Pro Thr Phe Ser Ser Pro Leu Val Ile Pro Pro Ser Gln 
785                 790                 795                 800 


Val Ser Glu Ser His Gly Gln Leu Ser Tyr Gln Ala Asp Leu Glu Ser 
                805                 810                 815     


Glu Thr Pro Gly Gln Leu Leu His Ala Asp Tyr Glu Glu Ser Leu Ser 
            820                 825                 830         


Gly Lys Asn Met Phe Pro Gln Ser Phe Gly Pro Asn Pro Phe Leu Gly 
        835                 840                 845             


Pro Val Pro Ile Ala Pro Pro Phe Phe Pro His Val Trp Tyr Gly Tyr 
    850                 855                 860                 


Pro Phe Gln Gly Phe Ile Glu Asn Pro Val Met Arg Gln Asn Ile Val 
865                 870                 875                 880 


Leu Pro Ser Asp Glu Lys Gly Glu Leu Asp Leu Ser Leu Glu Asn Leu 
                885                 890                 895     


Asp Leu Ser Lys Asp Cys Gly Ser Val Ser Thr Val Asp Glu Phe Pro 
            900                 905                 910         


Glu Ala Arg Gly Glu His Val His Ser Leu Pro Glu Ala Ser Val Ser 
        915                 920                 925             


Ser Lys Pro Asp Glu Gly Arg Thr Glu Gln Ser Ser Gln Thr Arg Lys 
    930                 935                 940                 


Ala Asp Thr Ala Leu Ala Ser Ile Pro Pro Val Ala Glu Gly Lys Ala 
945                 950                 955                 960 


His Pro Pro Thr Gln Ile Leu Asn Arg Glu Arg Glu Thr Val Pro Val 
                965                 970                 975     


Glu Leu Glu Pro Lys Arg Thr Ile Gln Ser Leu Lys Glu Lys Thr Glu 
            980                 985                 990         


Lys Val Lys Asp Pro Lys Thr Ala  Ala Asp Val Val Ser  Pro Gly Ala 
        995                 1000                 1005             


Asn Ser  Val Asp Ser Arg Val  Gln Arg Pro Lys Glu  Glu Ser Ser 
    1010                 1015                 1020             


Glu Asp  Glu Asn Glu Val Ser  Asn Ile Leu Arg Ser  Gly Arg Ser 
    1025                 1030                 1035             


Lys Gln  Phe Tyr Asn Gln Thr  Tyr Gly Ser Arg Lys  Tyr Lys Ser 
    1040                 1045                 1050             


Asp Trp  Gly Tyr Ser Gly Arg  Gly Gly Tyr Gln His  Val Arg Ser 
    1055                 1060                 1065             


Glu Glu  Ser Trp Lys Gly Gln  Pro Ser Arg Ser Arg  Asp Glu Gly 
    1070                 1075                 1080             


Tyr Gln  Tyr His Arg Asn Val  Arg Gly Arg Pro Phe  Arg Gly Asp 
    1085                 1090                 1095             


Arg Arg  Arg Ser Gly Met Gly  Asp Gly His Arg Gly  Gln His Thr 
    1100                 1105                 1110             


<210> 78
<211> 234
<212> PRT
<213> Homo sapiens

<400> 78
Met Ser Glu Thr Ser Phe Asn Leu Ile Ser Glu Lys Cys Asp Ile Leu 
1               5                   10                  15      


Ser Ile Leu Arg Asp His Pro Glu Asn Arg Ile Tyr Arg Arg Lys Ile 
            20                  25                  30          


Glu Glu Leu Ser Lys Arg Phe Thr Ala Ile Arg Lys Thr Lys Gly Asp 
        35                  40                  45              


Gly Asn Cys Phe Tyr Arg Ala Leu Gly Tyr Ser Tyr Leu Glu Ser Leu 
    50                  55                  60                  


Leu Gly Lys Ser Arg Glu Ile Phe Lys Phe Lys Glu Arg Val Leu Gln 
65                  70                  75                  80  


Thr Pro Asn Asp Leu Leu Ala Ala Gly Phe Glu Glu His Lys Phe Arg 
                85                  90                  95      


Asn Phe Phe Asn Ala Phe Tyr Ser Val Val Glu Leu Val Glu Lys Asp 
            100                 105                 110         


Gly Ser Val Ser Ser Leu Leu Lys Val Phe Asn Asp Gln Ser Ala Ser 
        115                 120                 125             


Asp His Ile Val Gln Phe Leu Arg Leu Leu Thr Ser Ala Phe Ile Arg 
    130                 135                 140                 


Asn Arg Ala Asp Phe Phe Arg His Phe Ile Asp Glu Glu Met Asp Ile 
145                 150                 155                 160 


Lys Asp Phe Cys Thr His Glu Val Glu Pro Met Ala Thr Glu Cys Asp 
                165                 170                 175     


His Ile Gln Ile Thr Ala Leu Ser Gln Ala Leu Ser Ile Ala Leu Gln 
            180                 185                 190         


Val Glu Tyr Val Asp Glu Met Asp Thr Ala Leu Asn His His Val Phe 
        195                 200                 205             


Pro Glu Ala Ala Thr Pro Ser Val Tyr Leu Leu Tyr Lys Thr Ser His 
    210                 215                 220                 


Tyr Asn Ile Leu Tyr Ala Ala Asp Lys His 
225                 230                 


<210> 79
<211> 398
<212> PRT
<213> Homo sapiens

<400> 79
Met Ser Arg Lys Gln Ala Ala Lys Ser Arg Pro Gly Ser Gly Ser Arg 
1               5                   10                  15      


Lys Ala Glu Ala Glu Arg Lys Arg Asp Glu Arg Ala Ala Arg Arg Ala 
            20                  25                  30          


Leu Ala Lys Glu Arg Arg Asn Arg Pro Glu Ser Gly Gly Gly Gly Gly 
        35                  40                  45              


Cys Glu Glu Glu Phe Val Ser Phe Ala Asn Gln Leu Gln Ala Leu Gly 
    50                  55                  60                  


Leu Lys Leu Arg Glu Val Pro Gly Asp Gly Asn Cys Leu Phe Arg Ala 
65                  70                  75                  80  


Leu Gly Asp Gln Leu Glu Gly His Ser Arg Asn His Leu Lys His Arg 
                85                  90                  95      


Gln Glu Thr Val Asp Tyr Met Ile Lys Gln Arg Glu Asp Phe Glu Pro 
            100                 105                 110         


Phe Val Glu Asp Asp Ile Pro Phe Glu Lys His Val Ala Ser Leu Ala 
        115                 120                 125             


Lys Pro Gly Thr Phe Ala Gly Asn Asp Ala Ile Val Ala Phe Ala Arg 
    130                 135                 140                 


Asn His Gln Leu Asn Val Val Ile His Gln Leu Asn Ala Pro Leu Trp 
145                 150                 155                 160 


Gln Ile Arg Gly Thr Glu Lys Ser Ser Val Arg Glu Leu His Ile Ala 
                165                 170                 175     


Tyr Arg Tyr Gly Glu His Tyr Asp Ser Val Arg Arg Ile Asn Asp Asn 
            180                 185                 190         


Ser Glu Ala Pro Ala His Leu Gln Thr Asp Phe Gln Met Leu His Gln 
        195                 200                 205             


Asp Glu Ser Asn Lys Arg Glu Lys Ile Lys Thr Lys Gly Met Asp Ser 
    210                 215                 220                 


Glu Asp Asp Leu Arg Asp Glu Val Glu Asp Ala Val Gln Lys Val Cys 
225                 230                 235                 240 


Asn Ala Thr Gly Cys Ser Asp Phe Asn Leu Ile Val Gln Asn Leu Glu 
                245                 250                 255     


Ala Glu Asn Tyr Asn Ile Glu Ser Ala Ile Ile Ala Val Leu Arg Met 
            260                 265                 270         


Asn Gln Gly Lys Arg Asn Asn Ala Glu Glu Asn Leu Glu Pro Ser Gly 
        275                 280                 285             


Arg Val Leu Lys Gln Cys Gly Pro Leu Trp Glu Glu Gly Gly Ser Gly 
    290                 295                 300                 


Ala Arg Ile Phe Gly Asn Gln Gly Leu Asn Glu Gly Arg Thr Glu Asn 
305                 310                 315                 320 


Asn Lys Ala Gln Ala Ser Pro Ser Glu Glu Asn Lys Ala Asn Lys Asn 
                325                 330                 335     


Gln Leu Ala Lys Val Thr Asn Lys Gln Arg Arg Glu Gln Gln Trp Met 
            340                 345                 350         


Glu Lys Lys Lys Arg Gln Glu Glu Arg His Arg His Lys Ala Leu Glu 
        355                 360                 365             


Ser Arg Gly Ser His Arg Asp Asn Asn Arg Ser Glu Ala Glu Ala Asn 
    370                 375                 380                 


Thr Gln Val Thr Leu Val Lys Thr Phe Ala Ala Leu Asn Ile 
385                 390                 395             


<210> 80
<211> 843
<212> PRT
<213> Homo sapiens

<400> 80
Met Thr Leu Asp Met Asp Ala Val Leu Ser Asp Phe Val Arg Ser Thr 
1               5                   10                  15      


Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu Leu Glu Gly Lys Asn Trp 
            20                  25                  30          


Asp Val Asn Ala Ala Leu Ser Asp Phe Glu Gln Leu Arg Gln Val His 
        35                  40                  45              


Ala Gly Asn Leu Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
    50                  55                  60                  


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
65                  70                  75                  80  


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
                85                  90                  95      


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
            100                 105                 110         


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
        115                 120                 125             


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
    130                 135                 140                 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
145                 150                 155                 160 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
                165                 170                 175     


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
            180                 185                 190         


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
        195                 200                 205             


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
    210                 215                 220                 


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
225                 230                 235                 240 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
                245                 250                 255     


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
            260                 265                 270         


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
        275                 280                 285             


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
    290                 295                 300                 


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
305                 310                 315                 320 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
                325                 330                 335     


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
            340                 345                 350         


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys 
        355                 360                 365             


Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr 
    370                 375                 380                 


Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu 
385                 390                 395                 400 


Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu 
                405                 410                 415     


Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys 
            420                 425                 430         


Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln Pro Glu 
        435                 440                 445             


Ser Pro Thr Ala Ser Ala Gly Asp Glu Pro Arg Ser Thr Pro Glu Ser 
    450                 455                 460                 


Gly Asp Ser Asp Lys Glu Ser Val Gly Ser Ser Ser Thr Ser Asn Glu 
465                 470                 475                 480 


Gly Gly Arg Arg Lys Glu Lys Ser Lys Arg Asp Arg Glu Lys Asp Lys 
                485                 490                 495     


Lys Arg Ala Asp Ser Val Ala Asn Lys Leu Gly Ser Phe Gly Lys Thr 
            500                 505                 510         


Leu Gly Ser Lys Leu Lys Lys Asn Met Gly Gly Leu Met His Ser Lys 
        515                 520                 525             


Gly Ser Lys Pro Gly Gly Val Gly Thr Gly Leu Gly Gly Ser Ser Gly 
    530                 535                 540                 


Thr Glu Thr Leu Glu Lys Lys Lys Lys Asn Ser Leu Lys Ser Trp Lys 
545                 550                 555                 560 


Gly Gly Lys Glu Glu Ala Ala Gly Asp Gly Pro Val Ser Glu Lys Pro 
                565                 570                 575     


Pro Ala Glu Ser Val Gly Asn Gly Gly Ser Lys Tyr Ser Gln Glu Val 
            580                 585                 590         


Met Gln Ser Leu Ser Ile Leu Arg Thr Ala Met Gln Gly Glu Gly Lys 
        595                 600                 605             


Phe Ile Phe Val Gly Thr Leu Lys Met Gly His Arg His Gln Tyr Gln 
    610                 615                 620                 


Glu Glu Met Ile Gln Arg Tyr Leu Ser Asp Ala Glu Glu Arg Phe Leu 
625                 630                 635                 640 


Ala Glu Gln Lys Gln Lys Glu Ala Glu Arg Lys Ile Met Asn Gly Gly 
                645                 650                 655     


Ile Gly Gly Gly Pro Pro Pro Ala Lys Lys Pro Glu Pro Asp Ala Arg 
            660                 665                 670         


Glu Glu Gln Pro Thr Gly Pro Pro Ala Glu Ser Arg Ala Met Ala Phe 
        675                 680                 685             


Ser Thr Gly Tyr Pro Gly Asp Phe Thr Ile Pro Arg Pro Ser Gly Gly 
    690                 695                 700                 


Gly Val His Cys Gln Glu Pro Arg Arg Gln Leu Ala Gly Gly Pro Cys 
705                 710                 715                 720 


Val Gly Gly Leu Pro Pro Tyr Ala Thr Phe Pro Arg Gln Cys Pro Pro 
                725                 730                 735     


Gly Arg Pro Tyr Pro His Gln Asp Ser Ile Pro Ser Leu Glu Pro Gly 
            740                 745                 750         


Ser His Ser Lys Asp Gly Leu His Arg Gly Ala Leu Leu Pro Pro Pro 
        755                 760                 765             


Tyr Arg Val Ala Asp Ser Tyr Ser Asn Gly Tyr Arg Glu Pro Pro Glu 
    770                 775                 780                 


Pro Asp Gly Trp Ala Gly Gly Leu Arg Gly Leu Pro Pro Thr Gln Thr 
785                 790                 795                 800 


Lys Cys Lys Gln Pro Asn Cys Ser Phe Tyr Gly His Pro Glu Thr Asn 
                805                 810                 815     


Asn Phe Cys Ser Cys Cys Tyr Arg Glu Glu Leu Arg Arg Arg Glu Arg 
            820                 825                 830         


Glu Pro Asp Gly Glu Leu Leu Val His Arg Phe 
        835                 840             


<210> 81
<211> 571
<212> PRT
<213> Homo sapiens

<400> 81
Met Thr Ile Leu Pro Lys Lys Lys Pro Pro Pro Pro Asp Ala Asp Pro 
1               5                   10                  15      


Ala Asn Glu Pro Pro Pro Pro Gly Pro Met Pro Pro Ala Pro Arg Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Val Gly Gly Gly Gly Thr Gly Val Gly Gly Gly 
        35                  40                  45              


Asp Arg Asp Arg Asp Ser Gly Val Val Gly Ala Arg Pro Arg Ala Ser 
    50                  55                  60                  


Pro Pro Pro Gln Gly Pro Leu Pro Gly Pro Pro Gly Ala Leu His Arg 
65                  70                  75                  80  


Trp Ala Leu Ala Val Pro Pro Gly Ala Val Ala Gly Pro Arg Pro Gln 
                85                  90                  95      


Gln Ala Ser Pro Pro Pro Cys Gly Gly Pro Gly Gly Pro Gly Gly Gly 
            100                 105                 110         


Pro Gly Asp Ala Leu Gly Ala Ala Ala Ala Gly Val Gly Ala Ala Gly 
        115                 120                 125             


Val Val Val Gly Val Gly Gly Ala Val Gly Val Gly Gly Cys Cys Ser 
    130                 135                 140                 


Gly Pro Gly His Ser Lys Arg Arg Arg Gln Ala Pro Gly Val Gly Ala 
145                 150                 155                 160 


Val Gly Gly Gly Ser Pro Glu Arg Glu Glu Val Gly Ala Gly Tyr Asn 
                165                 170                 175     


Ser Glu Asp Glu Tyr Glu Ala Ala Ala Ala Arg Ile Glu Ala Met Asp 
            180                 185                 190         


Pro Ala Thr Val Glu Gln Gln Glu His Trp Phe Glu Lys Ala Leu Arg 
        195                 200                 205             


Asp Lys Lys Gly Phe Ile Ile Lys Gln Met Lys Glu Asp Gly Ala Cys 
    210                 215                 220                 


Leu Phe Arg Ala Val Ala Asp Gln Val Tyr Gly Asp Gln Asp Met His 
225                 230                 235                 240 


Glu Val Val Arg Lys His Cys Met Asp Tyr Leu Met Lys Asn Ala Asp 
                245                 250                 255     


Tyr Phe Ser Asn Tyr Val Thr Glu Asp Phe Thr Thr Tyr Ile Asn Arg 
            260                 265                 270         


Lys Arg Lys Asn Asn Cys His Gly Asn His Ile Glu Met Gln Ala Met 
        275                 280                 285             


Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr Gln Tyr Ser Thr Gly 
    290                 295                 300                 


Thr Ser Ala Val Glu Pro Ile Asn Thr Phe His Gly Ile His Gln Asn 
305                 310                 315                 320 


Glu Asp Glu Pro Ile Arg Val Ser Tyr His Arg Asn Ile His Tyr Asn 
                325                 330                 335     


Ser Val Val Asn Pro Asn Lys Ala Thr Ile Gly Val Gly Leu Gly Leu 
            340                 345                 350         


Pro Ser Phe Lys Pro Gly Phe Ala Glu Gln Ser Leu Met Lys Asn Ala 
        355                 360                 365             


Ile Lys Thr Ser Glu Glu Ser Trp Ile Glu Gln Gln Met Leu Glu Asp 
    370                 375                 380                 


Lys Lys Arg Ala Thr Asp Trp Glu Ala Thr Asn Glu Ala Ile Glu Glu 
385                 390                 395                 400 


Gln Val Ala Arg Glu Ser Tyr Leu Gln Trp Leu Arg Asp Gln Glu Lys 
                405                 410                 415     


Gln Ala Arg Gln Val Arg Gly Pro Ser Gln Pro Arg Lys Ala Ser Ala 
            420                 425                 430         


Thr Cys Ser Ser Ala Thr Ala Ala Ala Ser Ser Gly Leu Glu Glu Trp 
        435                 440                 445             


Thr Ser Arg Ser Pro Arg Gln Arg Ser Ser Ala Ser Ser Pro Glu His 
    450                 455                 460                 


Pro Glu Leu His Ala Glu Leu Gly Met Lys Pro Pro Ser Pro Gly Thr 
465                 470                 475                 480 


Val Leu Ala Leu Ala Lys Pro Pro Ser Pro Cys Ala Pro Gly Thr Ser 
                485                 490                 495     


Ser Gln Phe Ser Ala Gly Ala Asp Arg Ala Thr Ser Pro Leu Val Ser 
            500                 505                 510         


Leu Tyr Pro Ala Leu Glu Cys Arg Ala Leu Ile Gln Gln Met Ser Pro 
        515                 520                 525             


Ser Ala Phe Gly Leu Asn Asp Trp Asp Asp Asp Glu Ile Leu Ala Ser 
    530                 535                 540                 


Val Leu Ala Val Ser Gln Gln Glu Tyr Leu Asp Ser Met Lys Lys Asn 
545                 550                 555                 560 


Lys Val His Arg Asp Pro Pro Pro Asp Lys Ser 
                565                 570     


<210> 82
<211> 790
<212> PRT
<213> Homo sapiens

<400> 82
Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 
            260                 265                 270         


Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 
        275                 280                 285             


His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 
    290                 295                 300                 


Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 
305                 310                 315                 320 


Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 
                325                 330                 335     


Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 
            340                 345                 350         


Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 
        355                 360                 365             


Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 
    370                 375                 380                 


Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 
385                 390                 395                 400 


Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 
                405                 410                 415     


Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 
            420                 425                 430         


Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 
        435                 440                 445             


Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 
    450                 455                 460                 


Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 
465                 470                 475                 480 


Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 
                485                 490                 495     


Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 
            500                 505                 510         


Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 
        515                 520                 525             


Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 
    530                 535                 540                 


Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 
545                 550                 555                 560 


Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 
                565                 570                 575     


His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 
            580                 585                 590         


Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 
        595                 600                 605             


Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 
    610                 615                 620                 


Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 
625                 630                 635                 640 


Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 
                645                 650                 655     


Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 
            660                 665                 670         


Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 
        675                 680                 685             


Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 
    690                 695                 700                 


Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 
705                 710                 715                 720 


Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 
                725                 730                 735     


Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 
            740                 745                 750         


Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 
        755                 760                 765             


His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 
    770                 775                 780                 


Phe Lys Gln Met Tyr Gly 
785                 790 


<210> 83
<211> 708
<212> PRT
<213> Homo sapiens

<400> 83
Met Ser Glu Arg Gly Ile Lys Trp Ala Cys Glu Tyr Cys Thr Tyr Glu 
1               5                   10                  15      


Asn Trp Pro Ser Ala Ile Lys Cys Thr Met Cys Arg Ala Gln Arg Pro 
            20                  25                  30          


Ser Gly Thr Ile Ile Thr Glu Asp Pro Phe Lys Ser Gly Ser Ser Asp 
        35                  40                  45              


Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly Ser Ser Pro 
    50                  55                  60                  


Leu Ile Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys Ser Ser Tyr 
65                  70                  75                  80  


Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys Thr Tyr Leu 
                85                  90                  95      


Asn Trp Pro Arg Ala Ile Arg Cys Thr Gln Cys Leu Ser Gln Arg Arg 
            100                 105                 110         


Thr Arg Ser Pro Thr Glu Ser Pro Gln Ser Ser Gly Ser Gly Ser Arg 
        115                 120                 125             


Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn Asp Arg Asn 
    130                 135                 140                 


Lys Leu Asn Thr Arg Thr Gln His Trp Thr Cys Ser Val Cys Thr Tyr 
145                 150                 155                 160 


Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp His Pro Arg 
                165                 170                 175     


Pro Asn Asn Ile Glu Ala Ile Glu Leu Ala Glu Thr Glu Glu Ala Ser 
            180                 185                 190         


Ser Ile Ile Asn Glu Gln Asp Arg Ala Arg Trp Arg Gly Ser Cys Ser 
        195                 200                 205             


Ser Gly Asn Ser Gln Arg Arg Ser Pro Pro Ala Thr Lys Arg Asp Ser 
    210                 215                 220                 


Glu Val Lys Met Asp Phe Gln Arg Ile Glu Leu Ala Gly Ala Val Gly 
225                 230                 235                 240 


Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
                245                 250                 255     


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
            260                 265                 270         


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
        275                 280                 285             


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
    290                 295                 300                 


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
305                 310                 315                 320 


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
                325                 330                 335     


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
            340                 345                 350         


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
        355                 360                 365             


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
    370                 375                 380                 


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
385                 390                 395                 400 


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
                405                 410                 415     


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
            420                 425                 430         


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
        435                 440                 445             


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
    450                 455                 460                 


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
465                 470                 475                 480 


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
                485                 490                 495     


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
            500                 505                 510         


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
        515                 520                 525             


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
    530                 535                 540                 


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
545                 550                 555                 560 


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
                565                 570                 575     


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met 
            580                 585                 590         


Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr 
        595                 600                 605             


Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg 
    610                 615                 620                 


Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu 
625                 630                 635                 640 


Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr 
                645                 650                 655     


Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn 
            660                 665                 670         


His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg 
        675                 680                 685             


Gln Ile Arg Pro Cys Thr Ser Leu Ser Asp Gly Glu Glu Asp Glu Asp 
    690                 695                 700                 


Asp Glu Asp Glu 
705             


<210> 84
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 84
Met Ser Gln Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Glu Ala Pro Gln Thr Pro Ser Ser Leu Ala Ser Ala Ala Ala 
            20                  25                  30          


Ser Gly Gly Leu Leu Lys Arg Arg Asp Arg Arg Ile Leu Ser Gly Ser 
        35                  40                  45              


Cys Pro Asp Pro Lys Cys Gln Ala Arg Leu Phe Phe Pro Ala Ser Gly 
    50                  55                  60                  


Ser Val Ser Ile Glu Cys Thr Glu Cys Gly Gln Arg His Glu Gln Gln 
65                  70                  75                  80  


Gln Leu Leu Gly Val Glu Glu Val Thr Asp Pro Asp Val Val Leu His 
                85                  90                  95      


Asn Leu Leu Arg Asn Ala Leu Leu Gly Val Thr Gly Ala Pro Lys Lys 
            100                 105                 110         


Asn Thr Glu Leu Val Lys Val Met Gly Leu Ser Asn Tyr His Cys Lys 
        115                 120                 125             


Leu Leu Ser Pro Ile Leu Ala Arg Tyr Gly Met Asp Lys Gln Thr Gly 
    130                 135                 140                 


Arg Ala Lys Leu Leu Arg Asp Met Asn Gln Gly Glu Leu Phe Asp Cys 
145                 150                 155                 160 


Ala Leu Leu Gly Asp Arg Ala Phe Leu Ile Glu Pro Glu His Val Asn 
                165                 170                 175     


Thr Val Gly Tyr Gly Lys Asp Arg Ser Gly Ser Leu Leu Tyr Leu His 
            180                 185                 190         


Asp Thr Leu Glu Asp Ile Lys Arg Ala Asn Lys Ser Gln Glu Cys Leu 
        195                 200                 205             


Ile Pro Val His Val Asp Gly Asp Gly His Cys Leu Val His Ala Val 
    210                 215                 220                 


Ser Arg Ala Leu Val Gly Arg Glu Leu Phe Trp His Ala Leu Arg Glu 
225                 230                 235                 240 


Asn Leu Lys Gln His Phe Gln Gln His Leu Ala Arg Tyr Gln Ala Leu 
                245                 250                 255     


Phe His Asp Phe Ile Asp Ala Ala Glu Trp Glu Asp Ile Ile Asn Glu 
            260                 265                 270         


Cys Asp Pro Leu Phe Val Pro Pro Glu Gly Val Pro Leu Gly Leu Arg 
        275                 280                 285             


Asn Ile His Ile Phe Gly Leu Ala Asn Val Leu His Arg Pro Ile Ile 
    290                 295                 300                 


Leu Leu Asp Ser Leu Ser Gly Met Arg Ser Ser Gly Asp Tyr Ser Ala 
305                 310                 315                 320 


Thr Phe Leu Pro Gly Leu Ile Pro Ala Glu Lys Cys Thr Gly Lys Asp 
                325                 330                 335     


Gly His Leu Asn Lys Pro Ile Cys Ile Ala Trp Ser Ser Ser Gly Arg 
            340                 345                 350         


Asn His Tyr Ile Pro Leu Val Gly Ile Lys Gly Ala Ala Leu Pro Lys 
        355                 360                 365             


Leu Pro Met Asn Leu Leu Pro Lys Ala Trp Gly Val Pro Gln Asp Leu 
    370                 375                 380                 


Ile Lys Lys Tyr Ile Lys Leu Glu Glu Asp Gly Gly Cys Val Ile Gly 
385                 390                 395                 400 


Gly Asp Arg Ser Leu Gln Asp Lys Tyr Leu Leu Arg Leu Val Ala Ala 
                405                 410                 415     


Met Glu Glu Val Phe Met Asp Lys His Gly Ile His Pro Ser Leu Val 
            420                 425                 430         


Ala Asp Val His Gln Tyr Phe Tyr Arg Arg Thr Gly Val Ile Gly Val 
        435                 440                 445             


Gln Pro Glu Glu Val Thr Ala Ala Ala Lys Lys Ala Val Met Asp Asn 
    450                 455                 460                 


Arg Leu His Lys Cys Leu Leu Cys Gly Ala Leu Ser Glu Leu His Val 
465                 470                 475                 480 


Pro Pro Glu Trp Leu Ala Pro Gly Gly Lys Leu Tyr Asn Leu Ala Lys 
                485                 490                 495     


Ser Thr His Gly Gln Leu Arg Thr Asp Lys Asn Tyr Ser Phe Pro Leu 
            500                 505                 510         


Asn Asn Leu Val Cys Ser Tyr Asp Ser Val Lys Asp Val Leu Val Pro 
        515                 520                 525             


Asp Tyr Gly Met Ser Asn Leu Thr Ala Cys Asn Trp Cys His Gly Thr 
    530                 535                 540                 


Ser Val Arg Lys Val Arg Gly Asp Gly Ser Ile Val Tyr Leu Asp Gly 
545                 550                 555                 560 


Asp Arg Thr Asn Ser Arg Ser Thr Gly Gly Lys Cys Gly Cys Gly Phe 
                565                 570                 575     


Lys His Phe Trp Asp Gly Lys Glu Tyr Asp Asn Leu Pro Glu Ala Phe 
            580                 585                 590         


Pro Ile Thr Leu Glu Trp Gly Gly Arg Val Val Arg Glu Thr Val Tyr 
        595                 600                 605             


Trp Phe Gln Tyr Glu Ser Asp Ser Ser Leu Asn Ser Asn Val Tyr Asp 
    610                 615                 620                 


Val Ala Met Lys Leu Val Thr Lys His Phe Pro Gly Glu Phe Gly Ser 
625                 630                 635                 640 


Glu Ile Leu Val Gln Lys Val Val His Thr Ile Leu His Gln Thr Ala 
                645                 650                 655     


Lys Lys Asn Pro Asp Asp Tyr Thr Pro Val Asn Ile Asp Gly Ala His 
            660                 665                 670         


Ala Gln Arg Val Gly Asp Val Gln Gly Gln Glu Ser Glu Ser Gln Leu 
        675                 680                 685             


Pro Thr Lys Ile Ile Leu Thr Gly Gln Lys Thr Lys Thr Leu His Lys 
    690                 695                 700                 


Glu Glu Leu Asn Met Ser Lys Thr Glu Arg Thr Ile Gln Gln Asn Ile 
705                 710                 715                 720 


Thr Glu Gln Ala Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys 
                725                 730                 735     


Gln Glu Gln Lys Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg 
            740                 745                 750         


Asp Gly Pro Ser Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser 
        755                 760                 765             


Pro Thr Thr Ser Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly 
    770                 775                 780                 


Arg Gln Ser Met Val Thr Leu Lys Ser Ser Thr Thr Phe Phe Glu Leu 
785                 790                 795                 800 


Gln Glu Ser Ile Ala Arg Glu Phe Asn Ile Pro Pro Tyr Leu Gln Cys 
                805                 810                 815     


Ile Arg Tyr Gly Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly 
            820                 825                 830         


Met Glu Lys Glu Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile 
        835                 840                 845             


Glu Ile Leu Lys Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His 
    850                 855                 860                 


Ser Ala His Thr Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu 
865                 870                 875                 880 


Ser Ser Lys Glu Leu Gln Glu Gln Ala Glu Lys Glu Met Tyr Ser Leu 
                885                 890                 895     


Cys Leu Leu Ala Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys 
            900                 905                 910         


Gly Leu Pro His Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met 
        915                 920                 925             


Lys Lys Thr Met Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His 
    930                 935                 940                 


Leu Pro Gly Lys Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg Leu Glu 
945                 950                 955                 960 


Leu Cys Val Asp Ala Ala Gly His Phe Pro Ile Gly Pro Asp Val Glu 
                965                 970                 975     


Asp Leu Val Lys Glu Ala Val Ser Gln Val Arg Ala Glu Ala Thr Thr 
            980                 985                 990         


Arg Ser Arg Glu Ser Ser Pro Ser  His Gly Leu Leu Lys  Leu Gly Ser 
        995                 1000                 1005             


Gly Gly  Val Val Lys Lys Lys  Ser Glu Gln Leu His  Asn Val Thr 
    1010                 1015                 1020             


Ala Phe  Gln Gly Lys Gly His  Ser Leu Gly Thr Ala  Ser Gly Asn 
    1025                 1030                 1035             


Pro His  Leu Asp Pro Arg Ala  Arg Glu Thr Ser Val  Val Arg Lys 
    1040                 1045                 1050             


His Asn  Thr Gly Thr Asp Phe  Ser Asn Ser Ser Thr  Lys Thr Glu 
    1055                 1060                 1065             


Pro Ser  Val Phe Thr Ala Ser  Ser Ser Asn Ser Glu  Leu Ile Arg 
    1070                 1075                 1080             


Ile Ala  Pro Gly Val Val Thr  Met Arg Asp Gly Arg  Gln Leu Asp 
    1085                 1090                 1095             


Pro Asp  Leu Val Glu Ala Gln  Arg Lys Lys Leu Gln  Glu Met Val 
    1100                 1105                 1110             


Ser Ser  Ile Gln Ala Ser Met  Asp Arg His Leu Arg  Asp Gln Ser 
    1115                 1120                 1125             


Thr Glu  Gln Ser Pro Ser Asp  Leu Pro Gln Arg Lys  Thr Glu Val 
    1130                 1135                 1140             


Val Ser  Ser Ser Ala Lys Ser  Gly Ser Leu Gln Thr  Gly Leu Pro 
    1145                 1150                 1155             


Glu Ser  Phe Pro Leu Thr Gly  Gly Thr Glu Asn Leu  Asn Thr Glu 
    1160                 1165                 1170             


Thr Thr  Asp Gly Cys Val Ala  Asp Ala Leu Gly Ala  Ala Phe Ala 
    1175                 1180                 1185             


Thr Arg  Ser Lys Ala Gln Arg  Gly Asn Ser Val Glu  Glu Leu Glu 
    1190                 1195                 1200             


Glu Met  Asp Ser Gln Asp Ala  Glu Met Thr Asn Thr  Thr Glu Pro 
    1205                 1210                 1215             


Met Asp  His Ser 
    1220         


<210> 85
<211> 230
<212> PRT
<213> Homo sapiens

<400> 85
Met Glu Gly Gln Arg Trp Leu Pro Leu Glu Ala Asn Pro Glu Val Thr 
1               5                   10                  15      


Asn Gln Phe Leu Lys Gln Leu Gly Leu His Pro Asn Trp Gln Phe Val 
            20                  25                  30          


Asp Val Tyr Gly Met Asp Pro Glu Leu Leu Ser Met Val Pro Arg Pro 
        35                  40                  45              


Val Cys Ala Val Leu Leu Leu Phe Pro Ile Thr Glu Lys Tyr Glu Val 
    50                  55                  60                  


Phe Arg Thr Glu Glu Glu Glu Lys Ile Lys Ser Gln Gly Gln Asp Val 
65                  70                  75                  80  


Thr Ser Ser Val Tyr Phe Met Lys Gln Thr Ile Ser Asn Ala Cys Gly 
                85                  90                  95      


Thr Ile Gly Leu Ile His Ala Ile Ala Asn Asn Lys Asp Lys Met His 
            100                 105                 110         


Phe Glu Ser Gly Ser Thr Leu Lys Lys Phe Leu Glu Glu Ser Val Ser 
        115                 120                 125             


Met Ser Pro Glu Glu Arg Ala Arg Tyr Leu Glu Asn Tyr Asp Ala Ile 
    130                 135                 140                 


Arg Val Thr His Glu Thr Ser Ala His Glu Gly Gln Thr Glu Ala Pro 
145                 150                 155                 160 


Ser Ile Asp Glu Lys Val Asp Leu His Phe Ile Ala Leu Val His Val 
                165                 170                 175     


Asp Gly His Leu Tyr Glu Leu Asp Gly Arg Lys Pro Phe Pro Ile Asn 
            180                 185                 190         


His Gly Glu Thr Ser Asp Glu Thr Leu Leu Glu Asp Ala Ile Glu Val 
        195                 200                 205             


Cys Lys Lys Phe Met Glu Arg Asp Pro Asp Glu Leu Arg Phe Asn Ala 
    210                 215                 220                 


Ile Ala Leu Ser Ala Ala 
225                 230 


<210> 86
<211> 223
<212> PRT
<213> Homo sapiens

<400> 86
Met Gln Leu Lys Pro Met Glu Ile Asn Pro Glu Met Leu Asn Lys Val 
1               5                   10                  15      


Leu Ser Arg Leu Gly Val Ala Gly Gln Trp Arg Phe Val Asp Val Leu 
            20                  25                  30          


Gly Leu Glu Glu Glu Ser Leu Gly Ser Val Pro Ala Pro Ala Cys Ala 
        35                  40                  45              


Leu Leu Leu Leu Phe Pro Leu Thr Ala Gln His Glu Asn Phe Arg Lys 
    50                  55                  60                  


Lys Gln Ile Glu Glu Leu Lys Gly Gln Glu Val Ser Pro Lys Val Tyr 
65                  70                  75                  80  


Phe Met Lys Gln Thr Ile Gly Asn Ser Cys Gly Thr Ile Gly Leu Ile 
                85                  90                  95      


His Ala Val Ala Asn Asn Gln Asp Lys Leu Gly Phe Glu Asp Gly Ser 
            100                 105                 110         


Val Leu Lys Gln Phe Leu Ser Glu Thr Glu Lys Met Ser Pro Glu Asp 
        115                 120                 125             


Arg Ala Lys Cys Phe Glu Lys Asn Glu Ala Ile Gln Ala Ala His Asp 
    130                 135                 140                 


Ala Val Ala Gln Glu Gly Gln Cys Arg Val Asp Asp Lys Val Asn Phe 
145                 150                 155                 160 


His Phe Ile Leu Phe Asn Asn Val Asp Gly His Leu Tyr Glu Leu Asp 
                165                 170                 175     


Gly Arg Met Pro Phe Pro Val Asn His Gly Ala Ser Ser Glu Asp Thr 
            180                 185                 190         


Leu Leu Lys Asp Ala Ala Lys Val Cys Arg Glu Phe Thr Glu Arg Glu 
        195                 200                 205             


Gln Gly Glu Val Arg Phe Ser Ala Val Ala Leu Cys Lys Ala Ala 
    210                 215                 220             


<210> 87
<211> 329
<212> PRT
<213> Homo sapiens

<400> 87
Met Thr Gly Asn Ala Gly Glu Trp Cys Leu Met Glu Ser Asp Pro Gly 
1               5                   10                  15      


Val Phe Thr Glu Leu Ile Lys Gly Phe Gly Cys Arg Gly Ala Gln Val 
            20                  25                  30          


Glu Glu Ile Trp Ser Leu Glu Pro Glu Asn Phe Glu Lys Leu Lys Pro 
        35                  40                  45              


Val His Gly Leu Ile Phe Leu Phe Lys Trp Gln Pro Gly Glu Glu Pro 
    50                  55                  60                  


Ala Gly Ser Val Val Gln Asp Ser Arg Leu Asp Thr Ile Phe Phe Ala 
65                  70                  75                  80  


Lys Gln Val Ile Asn Asn Ala Cys Ala Thr Gln Ala Ile Val Ser Val 
                85                  90                  95      


Leu Leu Asn Cys Thr His Gln Asp Val His Leu Gly Glu Thr Leu Ser 
            100                 105                 110         


Glu Phe Lys Glu Phe Ser Gln Ser Phe Asp Ala Ala Met Lys Gly Leu 
        115                 120                 125             


Ala Leu Ser Asn Ser Asp Val Ile Arg Gln Val His Asn Ser Phe Ala 
    130                 135                 140                 


Arg Gln Gln Met Phe Glu Phe Asp Thr Lys Thr Ser Ala Lys Glu Glu 
145                 150                 155                 160 


Asp Ala Phe His Phe Val Ser Tyr Val Pro Val Asn Gly Arg Leu Tyr 
                165                 170                 175     


Glu Leu Asp Gly Leu Arg Glu Gly Pro Ile Asp Leu Gly Ala Cys Asn 
            180                 185                 190         


Gln Asp Asp Trp Ile Ser Ala Val Arg Pro Val Ile Glu Lys Arg Ile 
        195                 200                 205             


Gln Lys Tyr Ser Glu Gly Glu Ile Arg Phe Asn Leu Met Ala Ile Val 
    210                 215                 220                 


Ser Asp Arg Lys Met Ile Tyr Glu Gln Lys Ile Ala Glu Leu Gln Arg 
225                 230                 235                 240 


Gln Leu Ala Glu Glu Glu Pro Met Asp Thr Asp Gln Gly Asn Ser Met 
                245                 250                 255     


Leu Ser Ala Ile Gln Ser Glu Val Ala Lys Asn Gln Met Leu Ile Glu 
            260                 265                 270         


Glu Glu Val Gln Lys Leu Lys Arg Tyr Lys Ile Glu Asn Ile Arg Arg 
        275                 280                 285             


Lys His Asn Tyr Leu Pro Phe Ile Met Glu Leu Leu Lys Thr Leu Ala 
    290                 295                 300                 


Glu His Gln Gln Leu Ile Pro Leu Val Glu Lys Ala Lys Glu Lys Gln 
305                 310                 315                 320 


Asn Ala Lys Lys Ala Gln Glu Thr Lys 
                325                 


<210> 88
<211> 361
<212> PRT
<213> Homo sapiens

<400> 88
Met Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Gly Asn Met Asp Asp Ser Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn Ser 
                85                  90                  95      


Pro Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly Lys 
        115                 120                 125             


Gln Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly Tyr 
145                 150                 155                 160 


Ser Ile Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Met Ile Arg Val Gln Gln Met His Arg Pro Lys Leu Ile 
            180                 185                 190         


Gly Glu Glu Leu Ala Gln Leu Lys Glu Gln Arg Val His Lys Thr Asp 
        195                 200                 205             


Leu Glu Arg Val Leu Glu Ala Asn Asp Gly Ser Gly Met Leu Asp Glu 
    210                 215                 220                 


Asp Glu Glu Asp Leu Gln Arg Ala Leu Ala Leu Ser Arg Gln Glu Ile 
225                 230                 235                 240 


Asp Met Glu Asp Glu Glu Ala Asp Leu Arg Arg Ala Ile Gln Leu Ser 
                245                 250                 255     


Met Gln Gly Ser Ser Arg Asn Ile Ser Gln Asp Met Thr Gln Thr Ser 
            260                 265                 270         


Gly Thr Asn Leu Thr Ser Glu Glu Leu Arg Lys Arg Arg Glu Ala Tyr 
        275                 280                 285             


Phe Glu Lys Gln Gln Gln Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gly Asp Leu Ser Gly Gln Ser Ser His Pro Cys Glu Arg Pro Ala 
305                 310                 315                 320 


Thr Ser Ser Gly Ala Leu Gly Ser Asp Leu Gly Asp Ala Met Ser Glu 
                325                 330                 335     


Glu Asp Met Leu Gln Ala Ala Val Thr Met Ser Leu Glu Thr Val Arg 
            340                 345                 350         


Asn Asp Leu Lys Thr Glu Gly Lys Lys 
        355                 360     


<210> 89
<211> 188
<212> PRT
<213> Homo sapiens

<400> 89
Met Ser Gln Ala Pro Gly Ala Gln Pro Ser Pro Pro Thr Val Tyr His 
1               5                   10                  15      


Glu Arg Gln Arg Leu Glu Leu Cys Ala Val His Ala Leu Asn Asn Val 
            20                  25                  30          


Leu Gln Gln Gln Leu Phe Ser Gln Glu Ala Ala Asp Glu Ile Cys Lys 
        35                  40                  45              


Arg Leu Ala Pro Asp Ser Arg Leu Asn Pro His Arg Ser Leu Leu Gly 
    50                  55                  60                  


Thr Gly Asn Tyr Asp Val Asn Val Ile Met Ala Ala Leu Gln Gly Leu 
65                  70                  75                  80  


Gly Leu Ala Ala Val Trp Trp Asp Arg Arg Arg Pro Leu Ser Gln Leu 
                85                  90                  95      


Ala Leu Pro Gln Val Leu Gly Leu Ile Leu Asn Leu Pro Ser Pro Val 
            100                 105                 110         


Ser Leu Gly Leu Leu Ser Leu Pro Leu Arg Arg Arg His Trp Val Ala 
        115                 120                 125             


Leu Arg Gln Val Asp Gly Val Tyr Tyr Asn Leu Asp Ser Lys Leu Arg 
    130                 135                 140                 


Ala Pro Glu Ala Leu Gly Asp Glu Asp Gly Val Arg Ala Phe Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Ala Gln Gly Leu Cys Glu Val Leu Leu Val Val Thr Lys 
                165                 170                 175     


Glu Val Glu Glu Lys Gly Ser Trp Leu Arg Thr Asp 
            180                 185             


<210> 90
<211> 202
<212> PRT
<213> Homo sapiens

<400> 90
Met Ser Cys Val Pro Trp Lys Gly Asp Lys Ala Lys Ser Glu Ser Leu 
1               5                   10                  15      


Glu Leu Pro Gln Ala Ala Pro Pro Gln Ile Tyr His Glu Lys Gln Arg 
            20                  25                  30          


Arg Glu Leu Cys Ala Leu His Ala Leu Asn Asn Val Phe Gln Asp Ser 
        35                  40                  45              


Asn Ala Phe Thr Arg Asp Thr Leu Gln Glu Ile Phe Gln Arg Leu Ser 
    50                  55                  60                  


Pro Asn Thr Met Val Thr Pro His Lys Lys Ser Met Leu Gly Asn Gly 
65                  70                  75                  80  


Asn Tyr Asp Val Asn Val Ile Met Ala Ala Leu Gln Thr Lys Gly Tyr 
                85                  90                  95      


Glu Ala Val Trp Trp Asp Lys Arg Arg Asp Val Gly Val Ile Ala Leu 
            100                 105                 110         


Thr Asn Val Met Gly Phe Ile Met Asn Leu Pro Ser Ser Leu Cys Trp 
        115                 120                 125             


Gly Pro Leu Lys Leu Pro Leu Lys Arg Gln His Trp Ile Cys Val Arg 
    130                 135                 140                 


Glu Val Gly Gly Ala Tyr Tyr Asn Leu Asp Ser Lys Leu Lys Met Pro 
145                 150                 155                 160 


Glu Trp Ile Gly Gly Glu Ser Glu Leu Arg Lys Phe Leu Lys His His 
                165                 170                 175     


Leu Arg Gly Lys Asn Cys Glu Leu Leu Leu Val Val Pro Glu Glu Val 
            180                 185                 190         


Glu Ala His Gln Ser Trp Arg Thr Asp Val 
        195                 200         


<210> 91
<211> 355
<212> PRT
<213> Homo sapiens

<400> 91
Met Asp Phe Ile Phe His Glu Lys Gln Glu Gly Phe Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ala Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Glu Tyr Leu Ala Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Glu Asn Met Asp Asp Thr Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Phe Trp Gly Leu Glu Ile Ile His Phe Asn Asn 
                85                  90                  95      


Pro Glu Tyr Gln Lys Leu Gly Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Gln His Trp Phe Thr Ile Arg Lys Phe Gly Lys 
        115                 120                 125             


His Trp Phe Asn Leu Asn Ser Leu Leu Ala Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Cys Leu Ala Asn Phe Leu Ala Arg Leu Gln Gln Gln Ala Tyr 
145                 150                 155                 160 


Ser Val Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Ile Ile Ser Val Glu Glu Met Asp Thr Pro Lys Leu Asn 
            180                 185                 190         


Gly Lys Lys Leu Val Lys Gln Lys Glu His Arg Val Tyr Lys Thr Val 
        195                 200                 205             


Leu Glu Lys Val Ser Glu Glu Ser Asp Glu Ser Gly Thr Ser Asp Gln 
    210                 215                 220                 


Asp Glu Glu Asp Phe Gln Arg Ala Leu Glu Leu Ser Arg Gln Glu Thr 
225                 230                 235                 240 


Asn Arg Glu Asp Glu His Leu Arg Ser Thr Ile Glu Leu Ser Met Gln 
                245                 250                 255     


Gly Ser Ser Gly Asn Thr Ser Gln Asp Leu Pro Lys Thr Ser Cys Val 
            260                 265                 270         


Thr Pro Ala Ser Glu Gln Pro Lys Lys Ile Lys Glu Asp Tyr Phe Glu 
        275                 280                 285             


Lys His Gln Gln Glu Gln Lys Gln Gln Gln Gln Gln Ser Asp Leu Pro 
    290                 295                 300                 


Gly His Ser Ser Tyr Leu His Glu Arg Pro Thr Thr Ser Ser Arg Ala 
305                 310                 315                 320 


Ile Glu Ser Asp Leu Ser Asp Asp Ile Ser Glu Gly Thr Val Gln Ala 
                325                 330                 335     


Ala Val Asp Thr Ile Leu Glu Ile Met Arg Lys Asn Leu Lys Ile Lys 
            340                 345                 350         


Gly Glu Lys 
        355 


<210> 92
<211> 445
<212> PRT
<213> Homo sapiens

<400> 92
Met Ser Glu Leu Thr Lys Glu Leu Met Glu Leu Val Trp Gly Thr Lys 
1               5                   10                  15      


Ser Ser Pro Gly Leu Ser Asp Thr Ile Phe Cys Arg Trp Thr Gln Gly 
            20                  25                  30          


Phe Val Phe Ser Glu Ser Glu Gly Ser Ala Leu Glu Gln Phe Glu Gly 
        35                  40                  45              


Gly Pro Cys Ala Val Ile Ala Pro Val Gln Ala Phe Leu Leu Lys Lys 
    50                  55                  60                  


Leu Leu Phe Ser Ser Glu Lys Ser Ser Trp Arg Asp Cys Ser Glu Glu 
65                  70                  75                  80  


Glu Gln Lys Glu Leu Leu Cys His Thr Leu Cys Asp Ile Leu Glu Ser 
                85                  90                  95      


Ala Cys Cys Asp His Ser Gly Ser Tyr Cys Leu Val Ser Trp Leu Arg 
            100                 105                 110         


Gly Lys Thr Thr Glu Glu Thr Ala Ser Ile Ser Gly Ser Pro Ala Glu 
        115                 120                 125             


Ser Ser Cys Gln Val Glu His Ser Ser Ala Leu Ala Val Glu Glu Leu 
    130                 135                 140                 


Gly Phe Glu Arg Phe His Ala Leu Ile Gln Lys Arg Ser Phe Arg Ser 
145                 150                 155                 160 


Leu Pro Glu Leu Lys Asp Ala Val Leu Asp Gln Tyr Ser Met Trp Gly 
                165                 170                 175     


Asn Lys Phe Gly Val Leu Leu Phe Leu Tyr Ser Val Leu Leu Thr Lys 
            180                 185                 190         


Gly Ile Glu Asn Ile Lys Asn Glu Ile Glu Asp Ala Ser Glu Pro Leu 
        195                 200                 205             


Ile Asp Pro Val Tyr Gly His Gly Ser Gln Ser Leu Ile Asn Leu Leu 
    210                 215                 220                 


Leu Thr Gly His Ala Val Ser Asn Val Trp Asp Gly Asp Arg Glu Cys 
225                 230                 235                 240 


Ser Gly Met Lys Leu Leu Gly Ile His Glu Gln Ala Ala Val Gly Phe 
                245                 250                 255     


Leu Thr Leu Met Glu Ala Leu Arg Tyr Cys Lys Val Gly Ser Tyr Leu 
            260                 265                 270         


Lys Ser Pro Lys Phe Pro Ile Trp Ile Val Gly Ser Glu Thr His Leu 
        275                 280                 285             


Thr Val Phe Phe Ala Lys Asp Met Ala Leu Val Ala Pro Glu Ala Pro 
    290                 295                 300                 


Ser Glu Gln Ala Arg Arg Val Phe Gln Thr Tyr Asp Pro Glu Asp Asn 
305                 310                 315                 320 


Gly Phe Ile Pro Asp Ser Leu Leu Glu Asp Val Met Lys Ala Leu Asp 
                325                 330                 335     


Leu Val Ser Asp Pro Glu Tyr Ile Asn Leu Met Lys Asn Lys Leu Asp 
            340                 345                 350         


Pro Glu Gly Leu Gly Ile Ile Leu Leu Gly Pro Phe Leu Gln Glu Phe 
        355                 360                 365             


Phe Pro Asp Gln Gly Ser Ser Gly Pro Glu Ser Phe Thr Val Tyr His 
    370                 375                 380                 


Tyr Asn Gly Leu Lys Gln Ser Asn Tyr Asn Glu Lys Val Met Tyr Val 
385                 390                 395                 400 


Glu Gly Thr Ala Val Val Met Gly Phe Glu Asp Pro Met Leu Gln Thr 
                405                 410                 415     


Asp Asp Thr Pro Ile Lys Arg Cys Leu Gln Thr Lys Trp Pro Tyr Ile 
            420                 425                 430         


Glu Leu Leu Trp Thr Thr Asp Arg Ser Pro Ser Leu Asn 
        435                 440                 445 


<210> 93
<211> 469
<212> PRT
<213> Homo sapiens

<400> 93
Met Glu Tyr His Gln Pro Glu Asp Pro Ala Pro Gly Lys Ala Gly Thr 
1               5                   10                  15      


Ala Glu Ala Val Ile Pro Glu Asn His Glu Val Leu Ala Gly Pro Asp 
            20                  25                  30          


Glu His Pro Gln Asp Thr Asp Ala Arg Asp Ala Asp Gly Glu Ala Arg 
        35                  40                  45              


Glu Arg Glu Pro Ala Asp Gln Ala Leu Leu Pro Ser Gln Cys Gly Asp 
    50                  55                  60                  


Asn Leu Glu Ser Pro Leu Pro Glu Ala Ser Ser Ala Pro Pro Gly Pro 
65                  70                  75                  80  


Thr Leu Gly Thr Leu Pro Glu Val Glu Thr Ile Arg Ala Cys Ser Met 
                85                  90                  95      


Pro Gln Glu Leu Pro Gln Ser Pro Arg Thr Arg Gln Pro Glu Pro Asp 
            100                 105                 110         


Phe Tyr Cys Val Lys Trp Ile Pro Trp Lys Gly Glu Gln Thr Pro Ile 
        115                 120                 125             


Ile Thr Gln Ser Thr Asn Gly Pro Cys Pro Leu Leu Ala Ile Met Asn 
    130                 135                 140                 


Ile Leu Phe Leu Gln Trp Lys Val Lys Leu Pro Pro Gln Lys Glu Val 
145                 150                 155                 160 


Ile Thr Ser Asp Glu Leu Met Ala His Leu Gly Asn Cys Leu Leu Ser 
                165                 170                 175     


Ile Lys Pro Gln Glu Lys Ser Glu Gly Leu Gln Leu Asn Phe Gln Gln 
            180                 185                 190         


Asn Val Asp Asp Ala Met Thr Val Leu Pro Lys Leu Ala Thr Gly Leu 
        195                 200                 205             


Asp Val Asn Val Arg Phe Thr Gly Val Ser Asp Phe Glu Tyr Thr Pro 
    210                 215                 220                 


Glu Cys Ser Val Phe Asp Leu Leu Gly Ile Pro Leu Tyr His Gly Trp 
225                 230                 235                 240 


Leu Val Asp Pro Gln Ser Pro Glu Ala Val Arg Ala Val Gly Lys Leu 
                245                 250                 255     


Ser Tyr Asn Gln Leu Val Glu Arg Ile Ile Thr Cys Lys His Ser Ser 
            260                 265                 270         


Asp Thr Asn Leu Val Thr Glu Gly Leu Ile Ala Glu Gln Phe Leu Glu 
        275                 280                 285             


Thr Thr Ala Ala Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ala 
    290                 295                 300                 


Ala Ala Lys Glu Gly Glu Leu Ser Val Phe Phe Arg Asn Asn His Phe 
305                 310                 315                 320 


Ser Thr Met Thr Lys His Lys Ser His Leu Tyr Leu Leu Val Thr Asp 
                325                 330                 335     


Gln Gly Phe Leu Gln Glu Glu Gln Val Val Trp Glu Ser Leu His Asn 
            340                 345                 350         


Val Asp Gly Asp Ser Cys Phe Cys Asp Ser Asp Phe His Leu Ser His 
        355                 360                 365             


Ser Leu Gly Lys Gly Pro Gly Ala Glu Gly Gly Ser Gly Ser Pro Glu 
    370                 375                 380                 


Thr Gln Leu Gln Val Asp Gln Asp Tyr Leu Ile Ala Leu Ser Leu Gln 
385                 390                 395                 400 


Gln Gln Gln Pro Arg Gly Pro Leu Gly Leu Thr Asp Leu Glu Leu Ala 
                405                 410                 415     


Gln Gln Leu Gln Gln Glu Glu Tyr Gln Gln Gln Gln Ala Ala Gln Pro 
            420                 425                 430         


Val Arg Met Arg Thr Arg Val Leu Ser Leu Gln Gly Arg Gly Ala Thr 
        435                 440                 445             


Ser Gly Arg Pro Ala Gly Glu Arg Arg Gln Arg Pro Lys His Glu Ser 
    450                 455                 460                 


Asp Cys Ile Leu Leu 
465                 


<210> 94
<211> 621
<212> PRT
<213> Homo sapiens

<400> 94
Met Glu Ser Ser Pro Glu Ser Leu Gln Pro Leu Glu His Gly Val Ala 
1               5                   10                  15      


Ala Gly Pro Ala Ser Gly Thr Gly Ser Ser Gln Glu Gly Leu Gln Glu 
            20                  25                  30          


Thr Arg Leu Ala Ala Gly Asp Gly Pro Gly Val Trp Ala Ala Glu Thr 
        35                  40                  45              


Ser Gly Gly Asn Gly Leu Gly Ala Ala Ala Ala Arg Arg Ser Leu Pro 
    50                  55                  60                  


Asp Ser Ala Ser Pro Ala Gly Ser Pro Glu Val Pro Gly Pro Cys Ser 
65                  70                  75                  80  


Ser Ser Ala Gly Leu Asp Leu Lys Asp Ser Gly Leu Glu Ser Pro Ala 
                85                  90                  95      


Ala Ala Glu Ala Pro Leu Arg Gly Gln Tyr Lys Val Thr Ala Ser Pro 
            100                 105                 110         


Glu Thr Ala Val Ala Gly Val Gly His Glu Leu Gly Thr Ala Gly Asp 
        115                 120                 125             


Ala Gly Ala Arg Pro Asp Leu Ala Gly Thr Cys Gln Ala Glu Leu Thr 
    130                 135                 140                 


Ala Ala Gly Ser Glu Glu Pro Ser Ser Ala Gly Gly Leu Ser Ser Ser 
145                 150                 155                 160 


Cys Ser Asp Pro Ser Pro Pro Gly Glu Ser Pro Ser Leu Asp Ser Leu 
                165                 170                 175     


Glu Ser Phe Ser Asn Leu His Ser Phe Pro Ser Ser Cys Glu Phe Asn 
            180                 185                 190         


Ser Glu Glu Gly Ala Glu Asn Arg Val Pro Glu Glu Glu Glu Gly Ala 
        195                 200                 205             


Ala Val Leu Pro Gly Ala Val Pro Leu Cys Lys Glu Glu Glu Gly Glu 
    210                 215                 220                 


Glu Thr Ala Gln Val Leu Ala Ala Ser Lys Glu Arg Phe Pro Gly Gln 
225                 230                 235                 240 


Ser Val Tyr His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro 
                245                 250                 255     


Ile Ile Thr Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu 
            260                 265                 270         


Asn Val Leu Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu 
        275                 280                 285             


Ile Ile Thr Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu 
    290                 295                 300                 


Asp Ala Lys Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu 
305                 310                 315                 320 


Gln Asn Met Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly 
                325                 330                 335     


Leu Asp Val Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr 
            340                 345                 350         


Pro Glu Cys Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly 
        355                 360                 365             


Trp Leu Val Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn 
    370                 375                 380                 


Cys Ser Tyr Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser 
385                 390                 395                 400 


Asp Asn Ser Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu 
                405                 410                 415     


Asn Asn Thr Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr 
            420                 425                 430         


Ser Thr Val Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His 
        435                 440                 445             


Phe Ser Thr Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr 
    450                 455                 460                 


Asp Gln Gly Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His 
465                 470                 475                 480 


Asn Val Asp Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg 
                485                 490                 495     


Pro Pro Ser Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile 
            500                 505                 510         


Asp Gln Asp Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser 
        515                 520                 525             


Gln Glu Ile Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu 
    530                 535                 540                 


Leu Ala Lys Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr 
545                 550                 555                 560 


Tyr Gln Glu Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr 
                565                 570                 575     


Gln Ala Gln Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg 
            580                 585                 590         


Gln Ser Gly Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp 
        595                 600                 605             


Lys Glu Lys Glu Lys Glu Lys Asn Ser Cys Val Ile Leu 
    610                 615                 620     


<210> 95
<211> 757
<212> PRT
<213> Homo sapiens

<400> 95
Met Asp Ser Leu Phe Val Glu Glu Val Ala Ala Ser Leu Val Arg Glu 
1               5                   10                  15      


Phe Leu Ser Arg Lys Gly Leu Lys Lys Thr Cys Val Thr Met Asp Gln 
            20                  25                  30          


Glu Arg Pro Arg Ser Asp Leu Ser Ile Asn Asn Arg Asn Asp Leu Arg 
        35                  40                  45              


Lys Val Leu His Leu Glu Phe Leu Tyr Lys Glu Asn Lys Ala Lys Glu 
    50                  55                  60                  


Asn Pro Leu Lys Thr Ser Leu Glu Leu Ile Thr Arg Tyr Phe Leu Asp 
65                  70                  75                  80  


His Phe Gly Asn Thr Ala Asn Asn Phe Thr Gln Asp Thr Pro Ile Pro 
                85                  90                  95      


Ala Leu Ser Val Pro Lys Lys Asn Asn Lys Val Pro Ser Arg Cys Ser 
            100                 105                 110         


Glu Thr Thr Leu Val Asn Ile Tyr Asp Leu Ser Asp Glu Asp Ala Gly 
        115                 120                 125             


Trp Arg Thr Ser Leu Ser Glu Thr Ser Lys Ala Arg His Asp Asn Leu 
    130                 135                 140                 


Asp Gly Asp Val Leu Gly Asn Phe Val Ser Ser Lys Arg Pro Pro His 
145                 150                 155                 160 


Lys Ser Lys Pro Met Gln Thr Val Pro Gly Glu Thr Pro Val Leu Thr 
                165                 170                 175     


Ser Ala Trp Glu Lys Ile Asp Lys Leu His Ser Glu Pro Ser Leu Asp 
            180                 185                 190         


Val Lys Arg Met Gly Glu Asn Ser Arg Pro Lys Ser Gly Leu Ile Val 
        195                 200                 205             


Arg Gly Met Met Ser Gly Pro Ile Ala Ser Ser Pro Gln Asp Ser Phe 
    210                 215                 220                 


His Arg His Tyr Leu Arg Arg Ser Ser Pro Ser Ser Ser Ser Thr Gln 
225                 230                 235                 240 


Pro Gln Glu Glu Ser Arg Lys Val Pro Glu Leu Phe Val Cys Thr Gln 
                245                 250                 255     


Gln Asp Ile Leu Ala Ser Ser Asn Ser Ser Pro Ser Arg Thr Ser Leu 
            260                 265                 270         


Gly Gln Leu Ser Glu Leu Thr Val Glu Arg Gln Lys Thr Thr Ala Ser 
        275                 280                 285             


Ser Pro Pro His Leu Pro Ser Lys Arg Leu Pro Pro Trp Asp Arg Ala 
    290                 295                 300                 


Arg Pro Arg Asp Pro Ser Glu Asp Thr Pro Ala Val Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Thr Asp Arg Met Pro Leu Lys Leu Tyr Leu Pro Gly Gly Asn Ser 
                325                 330                 335     


Arg Met Thr Gln Glu Arg Leu Glu Arg Ala Phe Lys Arg Gln Gly Ser 
            340                 345                 350         


Gln Pro Ala Pro Val Arg Lys Asn Gln Leu Leu Pro Ser Asp Lys Val 
        355                 360                 365             


Asp Gly Glu Leu Gly Ala Leu Arg Leu Glu Asp Val Glu Asp Glu Leu 
    370                 375                 380                 


Ile Arg Glu Glu Val Ile Leu Ser Pro Val Pro Ser Val Leu Lys Leu 
385                 390                 395                 400 


Gln Thr Ala Ser Lys Pro Ile Asp Leu Ser Val Ala Lys Glu Ile Lys 
                405                 410                 415     


Thr Leu Leu Phe Gly Ser Ser Phe Cys Cys Phe Asn Glu Glu Trp Lys 
            420                 425                 430         


Leu Gln Ser Phe Ser Phe Ser Asn Thr Ala Ser Leu Lys Tyr Gly Ile 
        435                 440                 445             


Val Gln Asn Lys Gly Gly Pro Cys Gly Val Leu Ala Ala Val Gln Gly 
    450                 455                 460                 


Cys Val Leu Gln Lys Leu Leu Phe Glu Gly Asp Ser Lys Ala Asp Cys 
465                 470                 475                 480 


Ala Gln Gly Leu Gln Pro Ser Asp Ala His Arg Thr Arg Cys Leu Val 
                485                 490                 495     


Leu Ala Leu Ala Asp Ile Val Trp Arg Ala Gly Gly Arg Glu Arg Ala 
            500                 505                 510         


Val Val Ala Leu Ala Ser Arg Thr Gln Gln Phe Ser Pro Thr Gly Lys 
        515                 520                 525             


Tyr Lys Ala Asp Gly Val Leu Glu Thr Leu Thr Leu His Ser Leu Thr 
    530                 535                 540                 


Cys Tyr Glu Asp Leu Val Thr Phe Leu Gln Gln Ser Ile His Gln Phe 
545                 550                 555                 560 


Glu Val Gly Pro Tyr Gly Cys Ile Leu Leu Thr Leu Ser Ala Ile Leu 
                565                 570                 575     


Ser Arg Ser Thr Glu Leu Ile Arg Gln Asp Phe Asp Val Pro Thr Ser 
            580                 585                 590         


His Leu Ile Gly Ala His Gly Tyr Cys Thr Gln Glu Leu Val Asn Leu 
        595                 600                 605             


Leu Leu Thr Gly Lys Ala Val Ser Asn Val Phe Asn Asp Val Val Glu 
    610                 615                 620                 


Leu Asp Ser Gly Asp Gly Asn Ile Thr Leu Leu Arg Gly Ile Ala Ala 
625                 630                 635                 640 


Arg Ser Asp Ile Gly Phe Leu Ser Leu Phe Glu His Tyr Asn Met Cys 
                645                 650                 655     


Gln Val Gly Cys Phe Leu Lys Thr Pro Arg Phe Pro Ile Trp Val Val 
            660                 665                 670         


Cys Ser Glu Ser His Phe Ser Ile Leu Phe Ser Leu Gln Pro Gly Leu 
        675                 680                 685             


Leu Arg Asp Trp Arg Thr Glu Arg Leu Phe Asp Leu Tyr Tyr Tyr Asp 
    690                 695                 700                 


Gly Leu Ala Asn Gln Gln Glu Gln Ile Arg Leu Thr Ile Asp Thr Thr 
705                 710                 715                 720 


Gln Thr Ile Ser Glu Asp Thr Asp Asn Asp Leu Val Pro Pro Leu Glu 
                725                 730                 735     


Leu Cys Ile Arg Thr Lys Trp Lys Gly Ala Ser Val Asn Trp Asn Gly 
            740                 745                 750         


Ser Asp Pro Ile Leu 
        755         


<210> 96
<211> 424
<212> PRT
<213> Homo sapiens

<400> 96
Met Ser Asp His Gly Asp Val Ser Leu Pro Pro Glu Asp Arg Val Arg 
1               5                   10                  15      


Ala Leu Ser Gln Leu Gly Ser Ala Val Glu Val Asn Glu Asp Ile Pro 
            20                  25                  30          


Pro Arg Arg Tyr Phe Arg Ser Gly Val Glu Ile Ile Arg Met Ala Ser 
        35                  40                  45              


Ile Tyr Ser Glu Glu Gly Asn Ile Glu His Ala Phe Ile Leu Tyr Asn 
    50                  55                  60                  


Lys Tyr Ile Thr Leu Phe Ile Glu Lys Leu Pro Lys His Arg Asp Tyr 
65                  70                  75                  80  


Lys Ser Ala Val Ile Pro Glu Lys Lys Asp Thr Val Lys Lys Leu Lys 
                85                  90                  95      


Glu Ile Ala Phe Pro Lys Ala Glu Glu Leu Lys Ala Glu Leu Leu Lys 
            100                 105                 110         


Arg Tyr Thr Lys Glu Tyr Thr Glu Tyr Asn Glu Glu Lys Lys Lys Glu 
        115                 120                 125             


Ala Glu Glu Leu Ala Arg Asn Met Ala Ile Gln Gln Glu Leu Glu Lys 
    130                 135                 140                 


Glu Lys Gln Arg Val Ala Gln Gln Lys Gln Gln Gln Leu Glu Gln Glu 
145                 150                 155                 160 


Gln Phe His Ala Phe Glu Glu Met Ile Arg Asn Gln Glu Leu Glu Lys 
                165                 170                 175     


Glu Arg Leu Lys Ile Val Gln Glu Phe Gly Lys Val Asp Pro Gly Leu 
            180                 185                 190         


Gly Gly Pro Leu Val Pro Asp Leu Glu Lys Pro Ser Leu Asp Val Phe 
        195                 200                 205             


Pro Thr Leu Thr Val Ser Ser Ile Gln Pro Ser Asp Cys His Thr Thr 
    210                 215                 220                 


Val Arg Pro Ala Lys Pro Pro Val Val Asp Arg Ser Leu Lys Pro Gly 
225                 230                 235                 240 


Ala Leu Ser Asn Ser Glu Ser Ile Pro Thr Ile Asp Gly Leu Arg His 
                245                 250                 255     


Val Val Val Pro Gly Arg Leu Cys Pro Gln Phe Leu Gln Leu Ala Ser 
            260                 265                 270         


Ala Asn Thr Ala Arg Gly Val Glu Thr Cys Gly Ile Leu Cys Gly Lys 
        275                 280                 285             


Leu Met Arg Asn Glu Phe Thr Ile Thr His Val Leu Ile Pro Lys Gln 
    290                 295                 300                 


Ser Ala Gly Ser Asp Tyr Cys Asn Thr Glu Asn Glu Glu Glu Leu Phe 
305                 310                 315                 320 


Leu Ile Gln Asp Gln Gln Gly Leu Ile Thr Leu Gly Trp Ile His Thr 
                325                 330                 335     


His Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His 
            340                 345                 350         


Cys Ser Tyr Gln Met Met Leu Pro Glu Ser Val Ala Ile Val Cys Ser 
        355                 360                 365             


Pro Lys Phe Gln Glu Thr Gly Phe Phe Lys Leu Thr Asp His Gly Leu 
    370                 375                 380                 


Glu Glu Ile Ser Ser Cys Arg Gln Lys Gly Phe His Pro His Ser Lys 
385                 390                 395                 400 


Asp Pro Pro Leu Phe Cys Ser Cys Ser His Val Thr Val Val Asp Arg 
                405                 410                 415     


Ala Val Thr Ile Thr Asp Leu Arg 
            420                 


<210> 97
<211> 471
<212> PRT
<213> Homo sapiens

<400> 97
Met Ala Ala Pro Glu Pro Leu Ser Pro Ala Gly Gly Ala Gly Glu Glu 
1               5                   10                  15      


Ala Pro Glu Glu Asp Glu Asp Glu Ala Glu Ala Glu Asp Pro Glu Arg 
            20                  25                  30          


Pro Asn Ala Gly Ala Gly Gly Gly Arg Ser Gly Gly Gly Gly Ser Ser 
        35                  40                  45              


Val Ser Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Cys Gly 
    50                  55                  60                  


Gly Pro Gly Gly Ala Leu Thr Arg Arg Ala Val Thr Leu Arg Val Leu 
65                  70                  75                  80  


Leu Lys Asp Ala Leu Leu Glu Pro Gly Ala Gly Val Leu Ser Ile Tyr 
                85                  90                  95      


Tyr Leu Gly Lys Lys Phe Leu Gly Asp Leu Gln Pro Asp Gly Arg Ile 
            100                 105                 110         


Met Trp Gln Glu Thr Gly Gln Thr Phe Asn Ser Pro Ser Ala Trp Ala 
        115                 120                 125             


Thr His Cys Lys Lys Leu Val Asn Pro Ala Lys Lys Ser Gly Cys Gly 
    130                 135                 140                 


Trp Ala Ser Val Lys Tyr Lys Gly Gln Lys Leu Asp Lys Tyr Lys Ala 
145                 150                 155                 160 


Thr Trp Leu Arg Leu His Gln Leu His Thr Pro Ala Thr Ala Ala Asp 
                165                 170                 175     


Glu Ser Pro Ala Ser Glu Gly Glu Glu Glu Glu Leu Leu Met Glu Glu 
            180                 185                 190         


Glu Glu Glu Asp Val Leu Ala Gly Val Ser Ala Glu Asp Lys Ser Arg 
        195                 200                 205             


Arg Pro Leu Gly Lys Ser Pro Ser Glu Pro Ala His Pro Glu Ala Thr 
    210                 215                 220                 


Thr Pro Gly Lys Arg Val Asp Ser Lys Ile Arg Val Pro Val Arg Tyr 
225                 230                 235                 240 


Cys Met Leu Gly Ser Arg Asp Leu Ala Arg Asn Pro His Thr Leu Val 
                245                 250                 255     


Glu Val Thr Ser Phe Ala Ala Ile Asn Lys Phe Gln Pro Phe Asn Val 
            260                 265                 270         


Ala Val Ser Ser Asn Val Leu Phe Leu Leu Asp Phe His Ser His Leu 
        275                 280                 285             


Thr Arg Ser Glu Val Val Gly Tyr Leu Gly Gly Arg Trp Asp Val Asn 
    290                 295                 300                 


Ser Gln Met Leu Thr Val Leu Arg Ala Phe Pro Cys Arg Ser Arg Leu 
305                 310                 315                 320 


Gly Asp Ala Glu Thr Ala Ala Ala Ile Glu Glu Glu Ile Tyr Gln Ser 
                325                 330                 335     


Leu Phe Leu Arg Gly Leu Ser Leu Val Gly Trp Tyr His Ser His Pro 
            340                 345                 350         


His Ser Pro Ala Leu Pro Ser Leu Gln Asp Ile Asp Ala Gln Met Asp 
        355                 360                 365             


Tyr Gln Leu Arg Leu Gln Gly Ser Ser Asn Gly Phe Gln Pro Cys Leu 
    370                 375                 380                 


Ala Leu Leu Cys Ser Pro Tyr Tyr Ser Gly Asn Pro Gly Pro Glu Ser 
385                 390                 395                 400 


Lys Ile Ser Pro Phe Trp Val Met Pro Pro Pro Glu Met Leu Leu Val 
                405                 410                 415     


Glu Phe Tyr Lys Gly Ser Pro Asp Leu Val Arg Leu Gln Glu Pro Trp 
            420                 425                 430         


Ser Gln Glu His Thr Tyr Leu Asp Lys Leu Lys Ile Ser Leu Ala Ser 
        435                 440                 445             


Arg Thr Pro Lys Asp Gln Ser Leu Cys His Val Leu Glu Gln Val Cys 
    450                 455                 460                 


Gly Val Leu Lys Gln Gly Ser 
465                 470     


<210> 98
<211> 208
<212> PRT
<213> Homo sapiens

<400> 98
Met Gly Glu Val Glu Ile Ser Ala Leu Ala Tyr Val Lys Met Cys Leu 
1               5                   10                  15      


His Ala Ala Arg Tyr Pro His Ala Ala Val Asn Gly Leu Phe Leu Ala 
            20                  25                  30          


Pro Ala Pro Arg Ser Gly Glu Cys Leu Cys Leu Thr Asp Cys Val Pro 
        35                  40                  45              


Leu Phe His Ser His Leu Ala Leu Ser Val Met Leu Glu Val Ala Leu 
    50                  55                  60                  


Asn Gln Val Asp Val Trp Gly Ala Gln Ala Gly Leu Val Val Ala Gly 
65                  70                  75                  80  


Tyr Tyr His Ala Asn Ala Ala Val Asn Asp Gln Ser Pro Gly Pro Leu 
                85                  90                  95      


Ala Leu Lys Ile Ala Gly Arg Ile Ala Glu Phe Phe Pro Asp Ala Val 
            100                 105                 110         


Leu Ile Met Leu Asp Asn Gln Lys Leu Val Pro Gln Pro Arg Val Pro 
        115                 120                 125             


Pro Val Ile Val Leu Glu Asn Gln Gly Leu Arg Trp Val Pro Lys Asp 
    130                 135                 140                 


Lys Asn Leu Val Met Trp Arg Asp Trp Glu Glu Ser Arg Gln Met Val 
145                 150                 155                 160 


Gly Ala Leu Leu Glu Asp Arg Ala His Gln His Leu Val Asp Phe Asp 
                165                 170                 175     


Cys His Leu Asp Asp Ile Arg Gln Asp Trp Thr Asn Gln Arg Leu Asn 
            180                 185                 190         


Thr Gln Ile Thr Gln Trp Val Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200                 205             


<210> 99
<211> 310
<212> PRT
<213> Homo sapiens

<400> 99
Met Asp Arg Leu Leu Arg Leu Gly Gly Gly Met Pro Gly Leu Gly Gln 
1               5                   10                  15      


Gly Pro Pro Thr Asp Ala Pro Ala Val Asp Thr Ala Glu Gln Val Tyr 
            20                  25                  30          


Ile Ser Ser Leu Ala Leu Leu Lys Met Leu Lys His Gly Arg Ala Gly 
        35                  40                  45              


Val Pro Met Glu Val Met Gly Leu Met Leu Gly Glu Phe Val Asp Asp 
    50                  55                  60                  


Tyr Thr Val Arg Val Ile Asp Val Phe Ala Met Pro Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Val Ser Val Glu Ala Val Asp Pro Val Phe Gln Ala Lys Met Leu 
                85                  90                  95      


Asp Met Leu Lys Gln Thr Gly Arg Pro Glu Met Val Val Gly Trp Tyr 
            100                 105                 110         


His Ser His Pro Gly Phe Gly Cys Trp Leu Ser Gly Val Asp Ile Asn 
        115                 120                 125             


Thr Gln Gln Ser Phe Glu Ala Leu Ser Glu Arg Ala Val Ala Val Val 
    130                 135                 140                 


Val Asp Pro Ile Gln Ser Val Lys Gly Lys Val Val Ile Asp Ala Phe 
145                 150                 155                 160 


Arg Leu Ile Asn Ala Asn Met Met Val Leu Gly His Glu Pro Arg Gln 
                165                 170                 175     


Thr Thr Ser Asn Leu Gly His Leu Asn Lys Pro Ser Ile Gln Ala Leu 
            180                 185                 190         


Ile His Gly Leu Asn Arg His Tyr Tyr Ser Ile Thr Ile Asn Tyr Arg 
        195                 200                 205             


Lys Asn Glu Leu Glu Gln Lys Met Leu Leu Asn Leu His Lys Lys Ser 
    210                 215                 220                 


Trp Met Glu Gly Leu Thr Leu Gln Asp Tyr Ser Glu His Cys Lys His 
225                 230                 235                 240 


Asn Glu Ser Val Val Lys Glu Met Leu Glu Leu Ala Lys Asn Tyr Asn 
                245                 250                 255     


Lys Ala Val Glu Glu Glu Asp Lys Met Thr Pro Glu Gln Leu Ala Ile 
            260                 265                 270         


Lys Asn Val Gly Lys Gln Asp Pro Lys Arg His Leu Glu Glu His Val 
        275                 280                 285             


Asp Val Leu Met Thr Ser Asn Ile Val Gln Cys Leu Ala Ala Met Leu 
    290                 295                 300                 


Asp Thr Val Val Phe Lys 
305                 310 


<210> 100
<211> 828
<212> PRT
<213> Homo sapiens

<400> 100
Met Ala Ala Glu Glu Ala Asp Val Asp Ile Glu Gly Asp Val Val Ala 
1               5                   10                  15      


Ala Ala Gly Ala Gln Pro Gly Ser Gly Glu Asn Thr Ala Ser Val Leu 
            20                  25                  30          


Gln Lys Asp His Tyr Leu Asp Ser Ser Trp Arg Thr Glu Asn Gly Leu 
        35                  40                  45              


Ile Pro Trp Thr Leu Asp Asn Thr Ile Ser Glu Glu Asn Arg Ala Val 
    50                  55                  60                  


Ile Glu Lys Met Leu Leu Glu Glu Glu Tyr Tyr Leu Ser Lys Lys Ser 
65                  70                  75                  80  


Gln Pro Glu Lys Val Trp Leu Asp Gln Lys Glu Asp Asp Lys Lys Tyr 
                85                  90                  95      


Met Lys Ser Leu Gln Lys Thr Ala Lys Ile Met Val His Ser Pro Thr 
            100                 105                 110         


Lys Pro Ala Ser Tyr Ser Val Lys Trp Thr Ile Glu Glu Lys Glu Leu 
        115                 120                 125             


Phe Glu Gln Gly Leu Ala Lys Phe Gly Arg Arg Trp Thr Lys Ile Ser 
    130                 135                 140                 


Lys Leu Ile Gly Ser Arg Thr Val Leu Gln Val Lys Ser Tyr Ala Arg 
145                 150                 155                 160 


Gln Tyr Phe Lys Asn Lys Val Lys Cys Gly Leu Asp Lys Glu Thr Pro 
                165                 170                 175     


Asn Gln Lys Thr Gly His Asn Leu Gln Val Lys Asn Glu Asp Lys Gly 
            180                 185                 190         


Thr Lys Ala Trp Thr Pro Ser Cys Leu Arg Gly Arg Ala Asp Pro Asn 
        195                 200                 205             


Leu Asn Ala Val Lys Ile Glu Lys Leu Ser Asp Asp Glu Glu Val Asp 
    210                 215                 220                 


Ile Thr Asp Glu Val Asp Glu Leu Ser Ser Gln Thr Pro Gln Lys Asn 
225                 230                 235                 240 


Ser Ser Ser Asp Leu Leu Leu Asp Phe Pro Asn Ser Lys Met His Glu 
                245                 250                 255     


Thr Asn Gln Gly Glu Phe Ile Thr Ser Asp Ser Gln Glu Ala Leu Phe 
            260                 265                 270         


Ser Lys Ser Ser Arg Gly Cys Leu Gln Asn Glu Lys Gln Asp Glu Thr 
        275                 280                 285             


Leu Ser Ser Ser Glu Ile Thr Leu Trp Thr Glu Lys Gln Ser Asn Gly 
    290                 295                 300                 


Asp Lys Lys Ser Ile Glu Leu Asn Asp Gln Lys Phe Asn Glu Leu Ile 
305                 310                 315                 320 


Lys Asn Cys Asn Lys His Asp Gly Arg Gly Ile Ile Val Asp Ala Arg 
                325                 330                 335     


Gln Leu Pro Ser Pro Glu Pro Cys Glu Ile Gln Lys Asn Leu Asn Asp 
            340                 345                 350         


Asn Glu Met Leu Phe His Ser Cys Gln Met Val Glu Glu Ser His Glu 
        355                 360                 365             


Glu Glu Glu Leu Lys Pro Pro Glu Gln Glu Ile Glu Ile Asp Arg Asn 
    370                 375                 380                 


Ile Ile Gln Glu Glu Glu Lys Gln Ala Ile Pro Glu Phe Phe Glu Gly 
385                 390                 395                 400 


Arg Gln Ala Lys Thr Pro Glu Arg Tyr Leu Lys Ile Arg Asn Tyr Ile 
                405                 410                 415     


Leu Asp Gln Trp Glu Ile Cys Lys Pro Lys Tyr Leu Asn Lys Thr Ser 
            420                 425                 430         


Val Arg Pro Gly Leu Lys Asn Cys Gly Asp Val Asn Cys Ile Gly Arg 
        435                 440                 445             


Ile His Thr Tyr Leu Glu Leu Ile Gly Ala Ile Asn Phe Gly Cys Glu 
    450                 455                 460                 


Gln Ala Val Tyr Asn Arg Pro Gln Thr Val Asp Lys Val Arg Ile Arg 
465                 470                 475                 480 


Asp Arg Lys Asp Ala Val Glu Ala Tyr Gln Leu Ala Gln Arg Leu Gln 
                485                 490                 495     


Ser Met Arg Thr Arg Arg Arg Arg Val Arg Asp Pro Trp Gly Asn Trp 
            500                 505                 510         


Cys Asp Ala Lys Asp Leu Glu Gly Gln Thr Phe Glu His Leu Ser Ala 
        515                 520                 525             


Glu Glu Leu Ala Lys Arg Arg Glu Glu Glu Lys Gly Arg Pro Val Lys 
    530                 535                 540                 


Ser Leu Lys Val Pro Arg Pro Thr Lys Ser Ser Phe Asp Pro Phe Gln 
545                 550                 555                 560 


Leu Ile Pro Cys Asn Phe Phe Ser Glu Glu Lys Gln Glu Pro Phe Gln 
                565                 570                 575     


Val Lys Val Ala Ser Glu Ala Leu Leu Ile Met Asp Leu His Ala His 
            580                 585                 590         


Val Ser Met Ala Glu Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser Glu 
        595                 600                 605             


Val Asp Lys Val Val Glu Val Cys Ala Ala Glu Pro Cys Asn Ser Leu 
    610                 615                 620                 


Ser Thr Gly Leu Gln Cys Glu Met Asp Pro Val Ser Gln Thr Gln Ala 
625                 630                 635                 640 


Ser Glu Thr Leu Ala Val Arg Gly Phe Ser Val Ile Gly Trp Tyr His 
                645                 650                 655     


Ser His Pro Ala Phe Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp Thr 
            660                 665                 670         


Gln Ala Lys Tyr Gln Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe Ile 
        675                 680                 685             


Gly Met Ile Val Ser Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr Ser 
    690                 695                 700                 


Gln Ile Thr Cys Leu Val Ile Ser Glu Glu Ile Ser Pro Asp Gly Ser 
705                 710                 715                 720 


Tyr Arg Leu Pro Tyr Lys Phe Glu Val Gln Gln Met Leu Glu Glu Pro 
                725                 730                 735     


Gln Trp Gly Leu Val Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys Tyr 
            740                 745                 750         


Arg Leu Ser His Ser Ser Val Pro Met Asp Lys Ile Phe Arg Arg Asp 
        755                 760                 765             


Ser Asp Leu Thr Cys Leu Gln Lys Leu Leu Glu Cys Met Arg Lys Thr 
    770                 775                 780                 


Leu Ser Lys Val Thr Asn Cys Phe Met Ala Glu Glu Phe Leu Thr Glu 
785                 790                 795                 800 


Ile Glu Asn Leu Phe Leu Ser Asn Tyr Lys Ser Asn Gln Glu Asn Gly 
                805                 810                 815     


Val Thr Glu Glu Asn Cys Thr Lys Glu Leu Leu Met 
            820                 825             


<210> 101
<211> 415
<212> PRT
<213> Homo sapiens

<400> 101
Met Ala Ala Ser Ile Ser Gly Tyr Thr Phe Ser Ala Val Cys Phe His 
1               5                   10                  15      


Ser Ala Asn Ser Asn Ala Asp His Glu Gly Phe Leu Leu Gly Glu Val 
            20                  25                  30          


Arg Gln Glu Glu Thr Phe Ser Ile Ser Asp Ser Gln Ile Ser Asn Thr 
        35                  40                  45              


Glu Phe Leu Gln Val Ile Glu Ile His Asn His Gln Pro Cys Ser Lys 
    50                  55                  60                  


Leu Phe Ser Phe Tyr Asp Tyr Ala Ser Lys Val Asn Glu Glu Ser Leu 
65                  70                  75                  80  


Asp Arg Ile Leu Lys Asp Arg Arg Lys Lys Val Ile Gly Trp Tyr Arg 
                85                  90                  95      


Phe Arg Arg Asn Thr Gln Gln Gln Met Ser Tyr Arg Glu Gln Val Leu 
            100                 105                 110         


His Lys Gln Leu Thr Arg Ile Leu Gly Val Pro Asp Leu Val Phe Leu 
        115                 120                 125             


Leu Phe Ser Phe Ile Ser Thr Ala Asn Asn Ser Thr His Ala Leu Glu 
    130                 135                 140                 


Tyr Val Leu Phe Arg Pro Asn Arg Arg Tyr Asn Gln Arg Ile Ser Leu 
145                 150                 155                 160 


Ala Ile Pro Asn Leu Gly Asn Thr Ser Gln Gln Glu Tyr Lys Val Ser 
                165                 170                 175     


Ser Val Pro Asn Thr Ser Gln Ser Tyr Ala Lys Val Ile Lys Glu His 
            180                 185                 190         


Gly Thr Asp Phe Phe Asp Lys Asp Gly Val Met Lys Asp Ile Arg Ala 
        195                 200                 205             


Ile Tyr Gln Val Tyr Asn Ala Leu Gln Glu Lys Val Gln Ala Val Cys 
    210                 215                 220                 


Ala Asp Val Glu Lys Ser Glu Arg Val Val Glu Ser Cys Gln Ala Glu 
225                 230                 235                 240 


Val Asn Lys Leu Arg Arg Gln Ile Thr Gln Arg Lys Asn Glu Lys Glu 
                245                 250                 255     


Gln Glu Arg Arg Leu Gln Gln Ala Val Leu Ser Arg Gln Met Pro Ser 
            260                 265                 270         


Glu Ser Leu Asp Pro Ala Phe Ser Pro Arg Met Pro Ser Ser Gly Phe 
        275                 280                 285             


Ala Ala Glu Gly Arg Ser Thr Leu Gly Asp Ala Glu Ala Ser Asp Pro 
    290                 295                 300                 


Pro Pro Pro Tyr Ser Asp Phe His Pro Asn Asn Gln Glu Ser Thr Leu 
305                 310                 315                 320 


Ser His Ser Arg Met Glu Arg Ser Val Phe Met Pro Arg Pro Gln Ala 
                325                 330                 335     


Val Gly Ser Ser Asn Tyr Ala Ser Thr Ser Ala Gly Leu Lys Tyr Pro 
            340                 345                 350         


Gly Ser Gly Ala Asp Leu Pro Pro Pro Gln Arg Ala Ala Gly Asp Ser 
        355                 360                 365             


Gly Glu Asp Ser Asp Asp Ser Asp Tyr Glu Asn Leu Ile Asp Pro Thr 
    370                 375                 380                 


Glu Pro Ser Asn Ser Glu Tyr Ser His Ser Lys Asp Ser Arg Pro Met 
385                 390                 395                 400 


Ala His Pro Asp Glu Asp Pro Arg Asn Thr Gln Thr Ser Gln Ile 
                405                 410                 415 


<210> 102
<211> 2335
<212> PRT
<213> Homo sapiens

<400> 102
Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210> 103
<211> 608
<212> PRT
<213> Homo sapiens

<400> 103
Met Ala Glu Ser Ile Ile Ile Arg Val Gln Ser Pro Asp Gly Val Lys 
1               5                   10                  15      


Arg Ile Thr Ala Thr Lys Arg Glu Thr Ala Ala Thr Phe Leu Lys Lys 
            20                  25                  30          


Val Ala Lys Glu Phe Gly Phe Gln Asn Asn Gly Phe Ser Val Tyr Ile 
        35                  40                  45              


Asn Arg Asn Lys Thr Gly Glu Ile Thr Ala Ser Ser Asn Lys Ser Leu 
    50                  55                  60                  


Asn Leu Leu Lys Ile Lys His Gly Asp Leu Leu Phe Leu Phe Pro Ser 
65                  70                  75                  80  


Ser Leu Ala Gly Pro Ser Ser Glu Met Glu Thr Ser Val Pro Pro Gly 
                85                  90                  95      


Phe Lys Val Phe Gly Ala Pro Asn Val Val Glu Asp Glu Ile Asp Gln 
            100                 105                 110         


Tyr Leu Ser Lys Gln Asp Gly Lys Ile Tyr Arg Ser Arg Asp Pro Gln 
        115                 120                 125             


Leu Cys Arg His Gly Pro Leu Gly Lys Cys Val His Cys Val Pro Leu 
    130                 135                 140                 


Glu Pro Phe Asp Glu Asp Tyr Leu Asn His Leu Glu Pro Pro Val Lys 
145                 150                 155                 160 


His Met Ser Phe His Ala Tyr Ile Arg Lys Leu Thr Gly Gly Ala Asp 
                165                 170                 175     


Lys Gly Lys Phe Val Ala Leu Glu Asn Ile Ser Cys Lys Ile Lys Ser 
            180                 185                 190         


Gly Cys Glu Gly His Leu Pro Trp Pro Asn Gly Ile Cys Thr Lys Cys 
        195                 200                 205             


Gln Pro Ser Ala Ile Thr Leu Asn Arg Gln Lys Tyr Arg His Val Asp 
    210                 215                 220                 


Asn Ile Met Phe Glu Asn His Thr Val Ala Asp Arg Phe Leu Asp Phe 
225                 230                 235                 240 


Trp Arg Lys Thr Gly Asn Gln His Phe Gly Tyr Leu Tyr Gly Arg Tyr 
                245                 250                 255     


Thr Glu His Lys Asp Ile Pro Leu Gly Ile Arg Ala Glu Val Ala Ala 
            260                 265                 270         


Ile Tyr Glu Pro Pro Gln Ile Gly Thr Gln Asn Ser Leu Glu Leu Leu 
        275                 280                 285             


Glu Asp Pro Lys Ala Glu Val Val Asp Glu Ile Ala Ala Lys Leu Gly 
    290                 295                 300                 


Leu Arg Lys Val Gly Trp Ile Phe Thr Asp Leu Val Ser Glu Asp Thr 
305                 310                 315                 320 


Arg Lys Gly Thr Val Arg Tyr Ser Arg Asn Lys Asp Thr Tyr Phe Leu 
                325                 330                 335     


Ser Ser Glu Glu Cys Ile Thr Ala Gly Asp Phe Gln Asn Lys His Pro 
            340                 345                 350         


Asn Met Cys Arg Leu Ser Pro Asp Gly His Phe Gly Ser Lys Phe Val 
        355                 360                 365             


Thr Ala Val Ala Thr Gly Gly Pro Asp Asn Gln Val His Phe Glu Gly 
    370                 375                 380                 


Tyr Gln Val Ser Asn Gln Cys Met Ala Leu Val Arg Asp Glu Cys Leu 
385                 390                 395                 400 


Leu Pro Cys Lys Asp Ala Pro Glu Leu Gly Tyr Ala Lys Glu Ser Ser 
                405                 410                 415     


Ser Glu Gln Tyr Val Pro Asp Val Phe Tyr Lys Asp Val Asp Lys Phe 
            420                 425                 430         


Gly Asn Glu Ile Thr Gln Leu Ala Arg Pro Leu Pro Val Glu Tyr Leu 
        435                 440                 445             


Ile Ile Asp Ile Thr Thr Thr Phe Pro Lys Asp Pro Val Tyr Thr Phe 
    450                 455                 460                 


Ser Ile Ser Gln Asn Pro Phe Pro Ile Glu Asn Arg Asp Val Leu Gly 
465                 470                 475                 480 


Glu Thr Gln Asp Phe His Ser Leu Ala Thr Tyr Leu Ser Gln Asn Thr 
                485                 490                 495     


Ser Ser Val Phe Leu Asp Thr Ile Ser Asp Phe His Leu Leu Leu Phe 
            500                 505                 510         


Leu Val Thr Asn Glu Val Met Pro Leu Gln Asp Ser Ile Ser Leu Leu 
        515                 520                 525             


Leu Glu Ala Val Arg Thr Arg Asn Glu Glu Leu Ala Gln Thr Trp Lys 
    530                 535                 540                 


Arg Ser Glu Gln Trp Ala Thr Ile Glu Gln Leu Cys Ser Thr Val Gly 
545                 550                 555                 560 


Gly Gln Leu Pro Gly Leu His Glu Tyr Gly Ala Val Gly Gly Ser Thr 
                565                 570                 575     


His Thr Ala Thr Ala Ala Met Trp Ala Cys Gln His Cys Thr Phe Met 
            580                 585                 590         


Asn Gln Pro Gly Thr Gly His Cys Glu Met Cys Ser Leu Pro Arg Thr 
        595                 600                 605             


<210> 104
<211> 210
<212> PRT
<213> Homo sapiens

<400> 104
Met Pro Gly Val Lys Leu Thr Thr Gln Ala Tyr Cys Lys Met Val Leu 
1               5                   10                  15      


His Gly Ala Lys Tyr Pro His Cys Ala Val Asn Gly Leu Leu Val Ala 
            20                  25                  30          


Glu Lys Gln Lys Pro Arg Lys Glu His Leu Pro Leu Gly Gly Pro Gly 
        35                  40                  45              


Ala His His Thr Leu Phe Val Asp Cys Ile Pro Leu Phe His Gly Thr 
    50                  55                  60                  


Leu Ala Leu Ala Pro Met Leu Glu Val Ala Leu Thr Leu Ile Asp Ser 
65                  70                  75                  80  


Trp Cys Lys Asp His Ser Tyr Val Ile Ala Gly Tyr Tyr Gln Ala Asn 
                85                  90                  95      


Glu Arg Val Lys Asp Ala Ser Pro Asn Gln Val Ala Glu Lys Val Ala 
            100                 105                 110         


Ser Arg Ile Ala Glu Gly Phe Ser Asp Thr Ala Leu Ile Met Val Asp 
        115                 120                 125             


Asn Thr Lys Phe Thr Met Asp Cys Val Ala Pro Thr Ile His Val Tyr 
    130                 135                 140                 


Glu His His Glu Asn Arg Trp Arg Cys Arg Asp Pro His His Asp Tyr 
145                 150                 155                 160 


Cys Glu Asp Trp Pro Glu Ala Gln Arg Ile Ser Ala Ser Leu Leu Asp 
                165                 170                 175     


Ser Arg Ser Tyr Glu Thr Leu Val Asp Phe Asp Asn His Leu Asp Asp 
            180                 185                 190         


Ile Arg Asn Asp Trp Thr Asn Pro Glu Ile Asn Lys Ala Val Leu His 
        195                 200                 205             


Leu Cys 
    210 


<210> 105
<211> 409
<212> PRT
<213> Homo sapiens

<400> 105
Met Glu Gly Glu Ser Thr Ser Ala Val Leu Ser Gly Phe Val Leu Gly 
1               5                   10                  15      


Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser Asp Thr Glu Gly Phe 
            20                  25                  30          


Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn Ser Ile Thr Asp Ser 
        35                  40                  45              


Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile Asp Ile Gln Lys Tyr 
    50                  55                  60                  


Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn Ser Ser Gly Glu Val 
65                  70                  75                  80  


Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn Val Lys Lys Asn Val 
                85                  90                  95      


Val Gly Trp Tyr Lys Phe Arg Arg His Ser Asp Gln Ile Met Thr Phe 
            100                 105                 110         


Arg Glu Arg Leu Leu His Lys Asn Leu Gln Glu His Phe Ser Asn Gln 
        115                 120                 125             


Asp Leu Val Phe Leu Leu Leu Thr Pro Ser Ile Ile Thr Glu Ser Cys 
    130                 135                 140                 


Ser Thr His Arg Leu Glu His Ser Leu Tyr Lys Pro Gln Lys Gly Leu 
145                 150                 155                 160 


Phe His Arg Val Pro Leu Val Val Ala Asn Leu Gly Met Ser Glu Gln 
                165                 170                 175     


Leu Gly Tyr Lys Thr Val Ser Gly Ser Cys Met Ser Thr Gly Phe Ser 
            180                 185                 190         


Arg Ala Val Gln Thr His Ser Ser Lys Phe Phe Glu Glu Asp Gly Ser 
        195                 200                 205             


Leu Lys Glu Val His Lys Ile Asn Glu Met Tyr Ala Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Lys Ser Ile Cys Lys Lys Val Glu Asp Ser Glu Gln Ala Val 
225                 230                 235                 240 


Asp Lys Leu Val Lys Asp Val Asn Arg Leu Lys Arg Glu Ile Glu Lys 
                245                 250                 255     


Arg Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu Lys Asn Ile Gln Lys 
            260                 265                 270         


Asp Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala Leu Arg Thr Phe Phe 
        275                 280                 285             


Pro Asn Ser Glu Phe Leu His Ser Cys Val Met Ser Leu Lys Asn Arg 
    290                 295                 300                 


His Val Ser Lys Ser Ser Cys Asn Tyr Asn His His Leu Asp Val Val 
305                 310                 315                 320 


Asp Asn Leu Thr Leu Met Val Glu His Thr Asp Ile Pro Glu Ala Ser 
                325                 330                 335     


Pro Ala Ser Thr Pro Gln Ile Ile Lys His Lys Ala Leu Asp Leu Asp 
            340                 345                 350         


Asp Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu Asp Thr Gln Asp Lys 
        355                 360                 365             


Arg Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln Asp Lys Ala Ser Lys 
    370                 375                 380                 


Met Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu Lys Met Lys Gly Phe 
385                 390                 395                 400 


Gly Glu Tyr Ser Arg Ser Pro Thr Phe 
                405                 


<210> 106
<211> 436
<212> PRT
<213> Homo sapiens

<400> 106
Met Asp Gln Pro Phe Thr Val Asn Ser Leu Lys Lys Leu Ala Ala Met 
1               5                   10                  15      


Pro Asp His Thr Asp Val Ser Leu Ser Pro Glu Glu Arg Val Arg Ala 
            20                  25                  30          


Leu Ser Lys Leu Gly Cys Asn Ile Thr Ile Ser Glu Asp Ile Thr Pro 
        35                  40                  45              


Arg Arg Tyr Phe Arg Ser Gly Val Glu Met Glu Arg Met Ala Ser Val 
    50                  55                  60                  


Tyr Leu Glu Glu Gly Asn Leu Glu Asn Ala Phe Val Leu Tyr Asn Lys 
65                  70                  75                  80  


Phe Ile Thr Leu Phe Val Glu Lys Leu Pro Asn His Arg Asp Tyr Gln 
                85                  90                  95      


Gln Cys Ala Val Pro Glu Lys Gln Asp Ile Met Lys Lys Leu Lys Glu 
            100                 105                 110         


Ile Ala Phe Pro Arg Thr Asp Glu Leu Lys Asn Asp Leu Leu Lys Lys 
        115                 120                 125             


Tyr Asn Val Glu Tyr Gln Glu Tyr Leu Gln Ser Lys Asn Lys Tyr Lys 
    130                 135                 140                 


Ala Glu Ile Leu Lys Lys Leu Glu His Gln Arg Leu Ile Glu Ala Glu 
145                 150                 155                 160 


Arg Lys Arg Ile Ala Gln Met Arg Gln Gln Gln Leu Glu Ser Glu Gln 
                165                 170                 175     


Phe Leu Phe Phe Glu Asp Gln Leu Lys Lys Gln Glu Leu Ala Arg Gly 
            180                 185                 190         


Gln Met Arg Ser Gln Gln Thr Ser Gly Leu Ser Glu Gln Ile Asp Gly 
        195                 200                 205             


Ser Ala Leu Ser Cys Phe Ser Thr His Gln Asn Asn Ser Leu Leu Asn 
    210                 215                 220                 


Val Phe Ala Asp Gln Pro Asn Lys Ser Asp Ala Thr Asn Tyr Ala Ser 
225                 230                 235                 240 


His Ser Pro Pro Val Asn Arg Ala Leu Thr Pro Ala Ala Thr Leu Ser 
                245                 250                 255     


Ala Val Gln Asn Leu Val Val Glu Gly Leu Arg Cys Val Val Leu Pro 
            260                 265                 270         


Glu Asp Leu Cys His Lys Phe Leu Gln Leu Ala Glu Ser Asn Thr Val 
        275                 280                 285             


Arg Gly Ile Glu Thr Cys Gly Ile Leu Cys Gly Lys Leu Thr His Asn 
    290                 295                 300                 


Glu Phe Thr Ile Thr His Val Ile Val Pro Lys Gln Ser Ala Gly Pro 
305                 310                 315                 320 


Asp Tyr Cys Asp Met Glu Asn Val Glu Glu Leu Phe Asn Val Gln Asp 
                325                 330                 335     


Gln His Asp Leu Leu Thr Leu Gly Trp Ile His Thr His Pro Thr Gln 
            340                 345                 350         


Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His Cys Ser Tyr Gln 
        355                 360                 365             


Leu Met Leu Pro Glu Ala Ile Ala Ile Val Cys Ser Pro Lys His Lys 
    370                 375                 380                 


Asp Thr Gly Ile Phe Arg Leu Thr Asn Ala Gly Met Leu Glu Val Ser 
385                 390                 395                 400 


Ala Cys Lys Lys Lys Gly Phe His Pro His Thr Lys Glu Pro Arg Leu 
                405                 410                 415     


Phe Ser Ile Cys Lys His Val Leu Val Lys Asp Ile Lys Ile Ile Val 
            420                 425                 430         


Leu Asp Leu Arg 
        435     


<210> 107
<211> 327
<212> PRT
<213> Homo sapiens

<400> 107
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His 
145                 150                 155                 160 


Thr Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala 
        195                 200                 205             


Thr Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr 
            260                 265                 270         


Asp Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210> 108
<211> 357
<212> PRT
<213> Homo sapiens

<400> 108
Met Ala Thr Pro Ala Val Pro Val Ser Ala Pro Pro Ala Thr Pro Thr 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Pro Ala Ser Val Pro Ala Pro Thr Pro Ala 
            20                  25                  30          


Pro Ala Ala Ala Pro Val Pro Ala Ala Ala Pro Ala Ser Ser Ser Asp 
        35                  40                  45              


Pro Ala Ala Ala Ala Ala Ala Thr Ala Ala Pro Gly Gln Thr Pro Ala 
    50                  55                  60                  


Ser Ala Gln Ala Pro Ala Gln Thr Pro Ala Pro Ala Leu Pro Gly Pro 
65                  70                  75                  80  


Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg Val Val Arg Leu His Pro 
                85                  90                  95      


Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu Arg Arg Asn Glu Gly 
            100                 105                 110         


Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr Val Asp Lys His Ser 
        115                 120                 125             


Val Glu Val Thr Asn Cys Phe Ser Val Pro His Asn Glu Ser Glu Asp 
    130                 135                 140                 


Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn Met Tyr Glu Leu His 
145                 150                 155                 160 


Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly Trp Tyr Ala Thr Gly 
                165                 170                 175     


His Asp Ile Thr Glu His Ser Val Leu Ile His Glu Tyr Tyr Ser Arg 
            180                 185                 190         


Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp Thr Ser Leu Gln Asn 
        195                 200                 205             


Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr Leu Met Gly Val Pro 
    210                 215                 220                 


Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu Thr Val Lys Tyr Ala 
225                 230                 235                 240 


Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu Ile Met Lys Thr Cys 
                245                 250                 255     


Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser Asp Leu Gln Gln Val 
            260                 265                 270         


Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu Ser Thr Val Leu Gln 
        275                 280                 285             


Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser Ala Asp Asn Thr Val 
    290                 295                 300                 


Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val Pro Lys Ile Val Pro 
305                 310                 315                 320 


Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile Asn Asp Leu Leu Met 
                325                 330                 335     


Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln Ile Ala Leu Asn Glu 
            340                 345                 350         


Lys Leu Val Asn Leu 
        355         


<210> 109
<211> 324
<212> PRT
<213> Homo sapiens

<400> 109
Met Pro Glu Leu Ala Val Gln Lys Val Val Val His Pro Leu Val Leu 
1               5                   10                  15      


Leu Ser Val Val Asp His Phe Asn Arg Ile Gly Lys Val Gly Asn Gln 
            20                  25                  30          


Lys Arg Val Val Gly Val Leu Leu Gly Ser Trp Gln Lys Lys Val Leu 
        35                  40                  45              


Asp Val Ser Asn Ser Phe Ala Val Pro Phe Asp Glu Asp Asp Lys Asp 
    50                  55                  60                  


Asp Ser Val Trp Phe Leu Asp His Asp Tyr Leu Glu Asn Met Tyr Gly 
65                  70                  75                  80  


Met Phe Lys Lys Val Asn Ala Arg Glu Arg Ile Val Gly Trp Tyr His 
                85                  90                  95      


Thr Gly Pro Lys Leu His Lys Asn Asp Ile Ala Ile Asn Glu Leu Met 
            100                 105                 110         


Lys Arg Tyr Cys Pro Asn Ser Val Leu Val Ile Ile Asp Val Lys Pro 
        115                 120                 125             


Lys Asp Leu Gly Leu Pro Thr Glu Ala Tyr Ile Ser Val Glu Glu Val 
    130                 135                 140                 


His Asp Asp Gly Thr Pro Thr Ser Lys Thr Phe Glu His Val Thr Ser 
145                 150                 155                 160 


Glu Ile Gly Ala Glu Glu Ala Glu Glu Val Gly Val Glu His Leu Leu 
                165                 170                 175     


Arg Asp Ile Lys Asp Thr Thr Val Gly Thr Leu Ser Gln Arg Ile Thr 
            180                 185                 190         


Asn Gln Val His Gly Leu Lys Gly Leu Asn Ser Lys Leu Leu Asp Ile 
        195                 200                 205             


Arg Ser Tyr Leu Glu Lys Val Ala Thr Gly Lys Leu Pro Ile Asn His 
    210                 215                 220                 


Gln Ile Ile Tyr Gln Leu Gln Asp Val Phe Asn Leu Leu Pro Asp Val 
225                 230                 235                 240 


Ser Leu Gln Glu Phe Val Lys Ala Phe Tyr Leu Lys Thr Asn Asp Gln 
                245                 250                 255     


Met Val Val Val Tyr Leu Ala Ser Leu Ile Arg Ser Val Val Ala Leu 
            260                 265                 270         


His Asn Leu Ile Asn Asn Lys Ile Ala Asn Arg Asp Ala Glu Lys Lys 
        275                 280                 285             


Glu Gly Gln Glu Lys Glu Glu Ser Lys Lys Asp Arg Lys Glu Asp Lys 
    290                 295                 300                 


Glu Lys Asp Lys Asp Lys Glu Lys Ser Asp Val Lys Lys Glu Glu Lys 
305                 310                 315                 320 


Lys Glu Lys Lys 
                


<210> 110
<211> 352
<212> PRT
<213> Homo sapiens

<400> 110
Met Ala Ser Arg Lys Glu Gly Thr Gly Ser Thr Ala Thr Ser Ser Ser 
1               5                   10                  15      


Ser Thr Ala Gly Ala Ala Gly Lys Gly Lys Gly Lys Gly Gly Ser Gly 
            20                  25                  30          


Asp Ser Ala Val Lys Gln Val Gln Ile Asp Gly Leu Val Val Leu Lys 
        35                  40                  45              


Ile Ile Lys His Tyr Gln Glu Glu Gly Gln Gly Thr Glu Val Val Gln 
    50                  55                  60                  


Gly Val Leu Leu Gly Leu Val Val Glu Asp Arg Leu Glu Ile Thr Asn 
65                  70                  75                  80  


Cys Phe Pro Phe Pro Gln His Thr Glu Asp Asp Ala Asp Phe Asp Glu 
                85                  90                  95      


Val Gln Tyr Gln Met Glu Met Met Arg Ser Leu Arg His Val Asn Ile 
            100                 105                 110         


Asp His Leu His Val Gly Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe 
        115                 120                 125             


Val Thr Arg Ala Leu Leu Asp Ser Gln Phe Ser Tyr Gln His Ala Ile 
    130                 135                 140                 


Glu Glu Ser Val Val Leu Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly 
145                 150                 155                 160 


Ser Leu Ser Leu Lys Ala Tyr Arg Leu Thr Pro Lys Leu Met Glu Val 
                165                 170                 175     


Cys Lys Glu Lys Asp Phe Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile 
            180                 185                 190         


Thr Phe Glu Tyr Met Phe Glu Glu Val Pro Ile Val Ile Lys Asn Ser 
        195                 200                 205             


His Leu Ile Asn Val Leu Met Trp Glu Leu Glu Lys Lys Ser Ala Val 
    210                 215                 220                 


Ala Asp Lys His Glu Leu Leu Ser Leu Ala Ser Ser Asn His Leu Gly 
225                 230                 235                 240 


Lys Asn Leu Gln Leu Leu Met Asp Arg Val Asp Glu Met Ser Gln Asp 
                245                 250                 255     


Ile Val Lys Tyr Asn Thr Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln 
            260                 265                 270         


Gln Lys His Gln Tyr Gln Gln Arg Arg Gln Gln Glu Asn Met Gln Arg 
        275                 280                 285             


Gln Ser Arg Gly Glu Pro Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu 
    290                 295                 300                 


Phe Lys Pro Pro Gln Pro Pro Ala Arg Met Asp Ser Leu Leu Ile Ala 
305                 310                 315                 320 


Gly Gln Ile Asn Thr Tyr Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln 
                325                 330                 335     


Asn Leu Gly Lys Leu Phe Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn 
            340                 345                 350         


<210> 111
<211> 334
<212> PRT
<213> Homo sapiens

<400> 111
Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Thr Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Thr Lys Asp 
        35                  40                  45              


His His Tyr Phe Lys Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys 
    50                  55                  60                  


Met Val Met His Ala Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu 
65                  70                  75                  80  


Met Leu Gly Lys Val Asp Gly Glu Thr Met Ile Ile Met Asp Ser Phe 
                85                  90                  95      


Ala Leu Pro Val Glu Gly Thr Glu Thr Arg Val Asn Ala Gln Ala Ala 
            100                 105                 110         


Ala Tyr Glu Tyr Met Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly 
        115                 120                 125             


Arg Leu Glu Asn Ala Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly 
    130                 135                 140                 


Cys Trp Leu Ser Gly Ile Asp Val Ser Thr Gln Met Leu Asn Gln Gln 
145                 150                 155                 160 


Phe Gln Glu Pro Phe Val Ala Val Val Ile Asp Pro Thr Arg Thr Ile 
                165                 170                 175     


Ser Ala Gly Lys Val Asn Leu Gly Ala Phe Arg Thr Tyr Pro Lys Gly 
            180                 185                 190         


Tyr Lys Pro Pro Asp Glu Gly Pro Ser Glu Tyr Gln Thr Ile Pro Leu 
        195                 200                 205             


Asn Lys Ile Glu Asp Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu 
    210                 215                 220                 


Glu Val Ser Tyr Phe Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu 
225                 230                 235                 240 


Leu Trp Asn Lys Tyr Trp Val Asn Thr Leu Ser Ser Ser Ser Leu Leu 
                245                 250                 255     


Thr Asn Ala Asp Tyr Thr Thr Gly Gln Val Phe Asp Leu Ser Glu Lys 
            260                 265                 270         


Leu Glu Gln Ser Glu Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly 
        275                 280                 285             


Leu Glu Thr His Asp Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Thr 
    290                 295                 300                 


Arg Asp Ser Cys Lys Thr Thr Ile Glu Ala Ile His Gly Leu Met Ser 
305                 310                 315                 320 


Gln Val Ile Lys Asp Lys Leu Phe Asn Gln Ile Asn Ile Ser 
                325                 330                 


<210> 112
<211> 316
<212> PRT
<213> Homo sapiens

<400> 112
Met Ala Val Gln Val Val Gln Ala Val Gln Ala Val His Leu Glu Ser 
1               5                   10                  15      


Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu Ser Thr Glu Lys Glu 
            20                  25                  30          


Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn Asp Asp Thr Arg Ser 
        35                  40                  45              


Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met Arg Thr Val Ala Glu 
    50                  55                  60                  


Lys Val Asp Ala Val Arg Ile Val His Ile His Ser Val Ile Ile Leu 
65                  70                  75                  80  


Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu Ile Ser Pro Glu Gln 
                85                  90                  95      


Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu Ala Glu Leu Thr Gly 
            100                 105                 110         


Arg Pro Met Arg Val Val Gly Trp Tyr His Ser His Pro His Ile Thr 
        115                 120                 125             


Val Trp Pro Ser His Val Asp Val Arg Thr Gln Ala Met Tyr Gln Met 
    130                 135                 140                 


Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser Cys Phe Ile Glu Asp 
145                 150                 155                 160 


Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr Cys Phe Gln Ser Ile 
                165                 170                 175     


Gln Ala Gln Lys Ser Ser Glu Ser Leu His Gly Pro Arg Asp Phe Trp 
            180                 185                 190         


Ser Ser Ser Gln His Ile Ser Ile Glu Gly Gln Lys Glu Glu Glu Arg 
        195                 200                 205             


Tyr Glu Arg Ile Glu Ile Pro Ile His Ile Val Pro His Val Thr Ile 
    210                 215                 220                 


Gly Lys Val Cys Leu Glu Ser Ala Val Glu Leu Pro Lys Ile Leu Cys 
225                 230                 235                 240 


Gln Glu Glu Gln Asp Ala Tyr Arg Arg Ile His Ser Leu Thr His Leu 
                245                 250                 255     


Asp Ser Val Thr Lys Ile His Asn Gly Ser Val Phe Thr Lys Asn Leu 
            260                 265                 270         


Cys Ser Gln Met Ser Ala Val Ser Gly Pro Leu Leu Gln Trp Leu Glu 
        275                 280                 285             


Asp Arg Leu Glu Gln Asn Gln Gln His Leu Gln Glu Leu Gln Gln Glu 
    290                 295                 300                 


Lys Glu Glu Leu Met Gln Glu Leu Ser Ser Leu Glu 
305                 310                 315     


<210> 113
<211> 368
<212> PRT
<213> Homo sapiens

<400> 113
Ser Ser Phe Thr Ile Gly Leu Arg Gly Leu Ile Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His Thr Pro Ile Leu 
            20                  25                  30          


Arg Asp Phe Phe Leu Ser Asp Arg His Arg Cys Glu Met Pro Ser Pro 
        35                  40                  45              


Glu Leu Cys Leu Val Cys Glu Met Ser Ser Leu Phe Arg Glu Leu Tyr 
    50                  55                  60                  


Ser Gly Asn Pro Ser Pro His Val Pro Tyr Lys Leu Leu His Leu Val 
65                  70                  75                  80  


Trp Ile His Ala Arg His Leu Ala Gly Tyr Arg Gln Gln Asp Ala His 
                85                  90                  95      


Glu Phe Leu Ile Ala Ala Leu Asp Val Leu His Arg His Cys Lys Gly 
            100                 105                 110         


Asp Asp Val Gly Lys Ala Ala Asn Asn Pro Asn His Cys Asn Cys Ile 
        115                 120                 125             


Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val Thr Cys Gln 
    130                 135                 140                 


Ala Cys His Gly Val Ser Thr Thr Ile Asp Pro Cys Trp Asp Ile Ser 
145                 150                 155                 160 


Leu Asp Leu Pro Gly Ser Cys Thr Ser Phe Trp Pro Met Ser Pro Gly 
                165                 170                 175     


Arg Glu Ser Ser Val Asn Gly Glu Ser His Ile Pro Gly Ile Thr Thr 
            180                 185                 190         


Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg Pro Glu His Leu Gly Ser 
        195                 200                 205             


Ser Ala Lys Ile Lys Cys Gly Ser Cys Gln Ser Tyr Gln Glu Ser Thr 
    210                 215                 220                 


Lys Gln Leu Thr Met Asn Lys Leu Pro Val Val Ala Cys Phe His Phe 
225                 230                 235                 240 


Lys Arg Phe Glu His Ser Ala Lys Gln Arg Arg Lys Ile Thr Thr Tyr 
                245                 250                 255     


Ile Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe Met Ala Ser Ser 
            260                 265                 270         


Lys Glu Ser Arg Met Asn Gly Gln Leu Gln Leu Pro Thr Asn Ser Gly 
        275                 280                 285             


Asn Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val Val Asn His Gln Gly 
    290                 295                 300                 


Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile Arg His His Lys Asp 
305                 310                 315                 320 


Gln Trp Phe Lys Cys Asp Asp Ala Val Ile Thr Lys Ala Ser Ile Lys 
                325                 330                 335     


Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu Phe Tyr His Lys Gln Val 
            340                 345                 350         


Leu Glu His Glu Ser Glu Lys Val Lys Glu Met Asn Thr Gln Ala Tyr 
        355                 360                 365             


<210> 114
<211> 353
<212> PRT
<213> Homo sapiens

<400> 114
Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys Glu Arg Arg Lys Lys 
1               5                   10                  15      


Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala Thr Cys Tyr Val Asn 
            20                  25                  30          


Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu Leu Arg Gln Ala Leu 
        35                  40                  45              


Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met Leu Gly Asp Gly Ile 
    50                  55                  60                  


Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile Cys Glu His Leu Gln 
65                  70                  75                  80  


Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg Arg Tyr Ile Asp Pro 
                85                  90                  95      


Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr Gly Gln Gln Gln Asp 
            100                 105                 110         


Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu Leu Glu Asp Thr Leu 
        115                 120                 125             


Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile Val Gln Gln Gln Phe 
    130                 135                 140                 


Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn Gln Cys Gly Arg Glu 
145                 150                 155                 160 


Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu Leu Asn Ile Gln Gly 
                165                 170                 175     


His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe Leu Lys Glu Glu Lys 
            180                 185                 190         


Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn Cys Gln Ser Lys Gln 
        195                 200                 205             


Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu Pro Cys Thr Leu Asn 
    210                 215                 220                 


Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln Thr Gly His Lys Lys 
225                 230                 235                 240 


Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile Leu Asp Met Glu Pro 
                245                 250                 255     


Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr Glu Leu Ser Ala Val 
            260                 265                 270         


Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly His Tyr Ile Ala His 
        275                 280                 285             


Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys Phe Asn Asp Glu Asp 
    290                 295                 300                 


Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu Gly Ile Glu Glu Asp 
305                 310                 315                 320 


Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys Pro Lys Cys Gly Lys 
                325                 330                 335     


Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu Val Tyr Arg Leu Gln 
            340                 345                 350         


Thr 
    


<210> 115
<211> 359
<212> PRT
<213> Homo sapiens

<400> 115
Thr Ala Ile Cys Ala Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Ile Leu Gln Ser Leu Ser Asn Ile Glu Gln Phe Cys Cys 
            20                  25                  30          


Tyr Phe Lys Glu Leu Pro Ala Val Glu Leu Arg Asn Gly Lys Thr Ala 
        35                  40                  45              


Gly Arg Arg Thr Tyr His Thr Arg Ser Gln Gly Asp Asn Asn Val Ser 
    50                  55                  60                  


Leu Val Glu Glu Phe Arg Lys Thr Leu Cys Ala Leu Trp Gln Gly Ser 
65                  70                  75                  80  


Gln Thr Ala Phe Ser Pro Glu Ser Leu Phe Tyr Val Val Trp Lys Ile 
                85                  90                  95      


Met Pro Asn Phe Arg Gly Tyr Gln Gln Gln Asp Ala His Glu Phe Met 
            100                 105                 110         


Arg Tyr Leu Leu Asp His Leu His Leu Glu Leu Gln Gly Gly Phe Asn 
        115                 120                 125             


Gly Val Ser Arg Ser Ala Ile Leu Gln Glu Asn Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Asn Lys Cys Cys Ile Asn Gly Ala Ser Thr Val Val Thr Ala Ile 
145                 150                 155                 160 


Phe Gly Gly Ile Leu Gln Asn Glu Val Asn Cys Leu Ile Cys Gly Thr 
                165                 170                 175     


Glu Ser Arg Lys Phe Asp Pro Phe Leu Asp Leu Ser Leu Asp Ile Pro 
            180                 185                 190         


Ser Gln Phe Arg Ser Lys Arg Ser Lys Asn Gln Glu Asn Gly Pro Val 
        195                 200                 205             


Cys Ser Leu Arg Asp Cys Leu Arg Ser Phe Thr Asp Leu Glu Glu Leu 
    210                 215                 220                 


Asp Glu Thr Glu Leu Tyr Met Cys His Lys Cys Lys Lys Lys Gln Lys 
225                 230                 235                 240 


Ser Thr Lys Lys Phe Trp Ile Gln Lys Leu Pro Lys Val Leu Cys Leu 
                245                 250                 255     


His Leu Lys Arg Phe His Trp Thr Ala Tyr Leu Arg Asn Lys Val Asp 
            260                 265                 270         


Thr Tyr Val Glu Phe Pro Leu Arg Gly Leu Asp Met Lys Cys Tyr Leu 
        275                 280                 285             


Leu Glu Pro Glu Asn Ser Gly Pro Glu Ser Cys Leu Tyr Asp Leu Ala 
    290                 295                 300                 


Ala Val Val Val His His Gly Ser Gly Val Gly Ser Gly His Tyr Thr 
305                 310                 315                 320 


Ala Tyr Ala Thr His Glu Gly Arg Trp Phe His Phe Asn Asp Ser Thr 
                325                 330                 335     


Val Thr Leu Thr Asp Glu Glu Thr Val Val Lys Ala Lys Ala Tyr Ile 
            340                 345                 350         


Leu Phe Tyr Val Glu His Gln 
        355                 


<210> 116
<211> 300
<212> PRT
<213> Homo sapiens

<400> 116
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 117
<211> 708
<212> PRT
<213> Homo sapiens

<400> 117
Leu Pro Phe Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn 
1               5                   10                  15      


Ser Ile Leu Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val 
            20                  25                  30          


Lys His Leu Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp 
        35                  40                  45              


Glu Ala Asn Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala 
    50                  55                  60                  


Ser Tyr Glu Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu 
                85                  90                  95      


Leu Ala Thr Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn 
            100                 105                 110         


Pro Met Tyr Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln 
        115                 120                 125             


Cys Ile Leu Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu 
    130                 135                 140                 


Glu Val Lys Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro 
145                 150                 155                 160 


His Pro Lys Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser 
                165                 170                 175     


Met Arg His Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly 
            180                 185                 190         


Lys Arg Lys Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys 
        195                 200                 205             


Leu Ser Lys Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg 
    210                 215                 220                 


Ser Lys Arg Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile 
225                 230                 235                 240 


Ile Pro Lys Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys 
                245                 250                 255     


Lys Ser Arg Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro 
            260                 265                 270         


Ser Ile Leu Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln 
        275                 280                 285             


Gly Val Lys Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp 
    290                 295                 300                 


Leu Gly Lys Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu 
305                 310                 315                 320 


Ser Pro Gly Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro 
                325                 330                 335     


Ile Asn Lys Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu 
            340                 345                 350         


Phe Gln Gly Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser 
        355                 360                 365             


Leu Thr Glu Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln 
    370                 375                 380                 


Glu Asp Glu Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu 
385                 390                 395                 400 


Pro Lys Thr Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala 
                405                 410                 415     


Ser Val Glu Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys 
            420                 425                 430         


His His Tyr Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro 
        435                 440                 445             


Glu Val Ile Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu 
    450                 455                 460                 


Phe Asp Cys Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu 
465                 470                 475                 480 


Thr Pro Leu Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn 
                485                 490                 495     


Asp Ser Tyr Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile 
            500                 505                 510         


Ser Ser Gly His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser 
        515                 520                 525             


Leu Glu Leu Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Ile 
    530                 535                 540                 


Gly Lys Pro Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu 
545                 550                 555                 560 


Asn Tyr Asn Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln 
                565                 570                 575     


Pro Ser Lys Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu 
            580                 585                 590         


Gly Gly Gln Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser 
        595                 600                 605             


Asn Pro Asp Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser 
    610                 615                 620                 


Glu Thr Ser Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu 
625                 630                 635                 640 


Ser Ser Asp Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile 
                645                 650                 655     


Ser Tyr Val Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu 
            660                 665                 670         


Phe Asp Asp Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn 
        675                 680                 685             


Ser Leu Ser Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe 
    690                 695                 700                 


Tyr Lys Lys Leu 
705             


<210> 118
<211> 1164
<212> PRT
<213> Homo sapiens

<400> 118
Phe Thr Asn Leu Ser Gly Ile Arg Asn Gln Gly Gly Thr Cys Tyr Leu 
1               5                   10                  15      


Asn Ser Leu Leu Gln Thr Leu His Phe Thr Pro Glu Phe Arg Glu Ala 
            20                  25                  30          


Leu Phe Ser Leu Gly Pro Glu Glu Leu Gly Leu Phe Glu Asp Lys Asp 
        35                  40                  45              


Lys Pro Asp Ala Lys Val Arg Ile Ile Pro Leu Gln Leu Gln Arg Leu 
    50                  55                  60                  


Phe Ala Gln Leu Leu Leu Leu Asp Gln Glu Ala Ala Ser Thr Ala Asp 
65                  70                  75                  80  


Leu Thr Asp Ser Phe Gly Trp Thr Ser Asn Glu Glu Met Arg Gln His 
                85                  90                  95      


Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala Leu Glu Thr Ser 
            100                 105                 110         


Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg Leu Tyr His Gly 
        115                 120                 125             


Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys Asn Val Ser Glu 
    130                 135                 140                 


Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val Lys Asn Val Ser 
145                 150                 155                 160 


Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu Glu Glu Val Phe 
                165                 170                 175     


Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp Arg Leu Val Lys 
            180                 185                 190         


Ala Ala Lys Ser Ala Lys Leu Arg Lys Leu Pro Pro Phe Leu Thr Val 
        195                 200                 205             


Ser Leu Leu Arg Phe Asn Phe Asp Phe Val Lys Cys Glu Arg Tyr Lys 
    210                 215                 220                 


Glu Thr Ser Cys Tyr Thr Phe Pro Leu Arg Ile Asn Leu Lys Pro Phe 
225                 230                 235                 240 


Cys Glu Gln Ser Glu Leu Asp Asp Leu Glu Tyr Ile Tyr Asp Leu Phe 
                245                 250                 255     


Ser Val Ile Ile His Lys Gly Gly Cys Tyr Gly Gly His Tyr His Val 
            260                 265                 270         


Tyr Ile Lys Asp Val Asp His Leu Gly Asn Trp Gln Phe Gln Glu Glu 
        275                 280                 285             


Lys Ser Lys Pro Asp Val Asn Leu Lys Asp Leu Gln Ser Glu Glu Glu 
    290                 295                 300                 


Ile Asp His Pro Leu Met Ile Leu Lys Ala Ile Leu Leu Glu Glu Asn 
305                 310                 315                 320 


Asn Leu Ile Pro Val Asp Gln Leu Gly Gln Lys Leu Leu Lys Lys Ile 
                325                 330                 335     


Gly Ile Ser Trp Asn Lys Lys Tyr Arg Lys Gln His Gly Pro Leu Arg 
            340                 345                 350         


Lys Phe Leu Gln Leu His Ser Gln Ile Phe Leu Leu Ser Ser Asp Glu 
        355                 360                 365             


Ser Thr Val Arg Leu Leu Lys Asn Ser Ser Leu Gln Ala Glu Ser Asp 
    370                 375                 380                 


Phe Gln Arg Asn Asp Gln Gln Ile Phe Lys Met Leu Pro Pro Glu Ser 
385                 390                 395                 400 


Pro Gly Leu Asn Asn Ser Ile Ser Cys Pro His Trp Phe Asp Ile Asn 
                405                 410                 415     


Asp Ser Lys Val Gln Pro Ile Arg Glu Lys Asp Ile Glu Gln Gln Phe 
            420                 425                 430         


Gln Gly Lys Glu Ser Ala Tyr Met Leu Phe Tyr Arg Lys Ser Gln Leu 
        435                 440                 445             


Gln Arg Pro Pro Glu Ala Arg Ala Asn Pro Arg Tyr Gly Val Pro Cys 
    450                 455                 460                 


His Leu Leu Asn Glu Met Asp Ala Ala Asn Ile Glu Leu Gln Thr Lys 
465                 470                 475                 480 


Arg Ala Glu Cys Asp Ser Ala Asn Asn Thr Phe Glu Leu His Leu His 
                485                 490                 495     


Leu Gly Pro Gln Tyr His Phe Phe Asn Gly Ala Leu His Pro Val Val 
            500                 505                 510         


Ser Gln Thr Glu Ser Val Trp Asp Leu Thr Phe Asp Lys Arg Lys Thr 
        515                 520                 525             


Leu Gly Asp Leu Arg Gln Ser Ile Phe Gln Leu Leu Glu Phe Trp Glu 
    530                 535                 540                 


Gly Asp Met Val Leu Ser Val Ala Lys Leu Val Pro Ala Gly Leu His 
545                 550                 555                 560 


Ile Tyr Gln Ser Leu Gly Gly Asp Glu Leu Thr Leu Cys Glu Thr Glu 
                565                 570                 575     


Ile Ala Asp Gly Glu Asp Ile Phe Val Trp Asn Gly Val Glu Val Gly 
            580                 585                 590         


Gly Val His Ile Gln Thr Gly Ile Asp Cys Glu Pro Leu Leu Leu Asn 
        595                 600                 605             


Val Leu His Leu Asp Thr Ser Ser Asp Gly Glu Lys Cys Cys Gln Val 
    610                 615                 620                 


Ile Glu Ser Pro His Val Phe Pro Ala Asn Ala Glu Val Gly Thr Val 
625                 630                 635                 640 


Leu Thr Ala Leu Ala Ile Pro Ala Gly Val Ile Phe Ile Asn Ser Ala 
                645                 650                 655     


Gly Cys Pro Gly Gly Glu Gly Trp Thr Ala Ile Pro Lys Glu Asp Met 
            660                 665                 670         


Arg Lys Thr Phe Arg Glu Gln Gly Leu Arg Asn Gly Ser Ser Ile Leu 
        675                 680                 685             


Ile Gln Asp Ser His Asp Asp Asn Ser Leu Leu Thr Lys Glu Glu Lys 
    690                 695                 700                 


Trp Val Thr Ser Met Asn Glu Ile Asp Trp Leu His Val Lys Asn Leu 
705                 710                 715                 720 


Cys Gln Leu Glu Ser Glu Glu Lys Gln Val Lys Ile Ser Ala Thr Val 
                725                 730                 735     


Asn Thr Met Val Phe Asp Ile Arg Ile Lys Ala Ile Lys Glu Leu Lys 
            740                 745                 750         


Leu Met Lys Glu Leu Ala Asp Asn Ser Cys Leu Arg Pro Ile Asp Arg 
        755                 760                 765             


Asn Gly Lys Leu Leu Cys Pro Val Pro Asp Ser Tyr Thr Leu Lys Glu 
    770                 775                 780                 


Ala Glu Leu Lys Met Gly Ser Ser Leu Gly Leu Cys Leu Gly Lys Ala 
785                 790                 795                 800 


Pro Ser Ser Ser Gln Leu Phe Leu Phe Phe Ala Met Gly Ser Asp Val 
                805                 810                 815     


Gln Pro Gly Thr Glu Met Glu Ile Val Val Glu Glu Thr Ile Ser Val 
            820                 825                 830         


Arg Asp Cys Leu Lys Leu Met Leu Lys Lys Ser Gly Leu Gln Gly Asp 
        835                 840                 845             


Ala Trp His Leu Arg Lys Met Asp Trp Cys Tyr Glu Ala Gly Glu Pro 
    850                 855                 860                 


Leu Cys Glu Glu Asp Ala Thr Leu Lys Glu Leu Leu Ile Cys Ser Gly 
865                 870                 875                 880 


Asp Thr Leu Leu Leu Ile Glu Gly Gln Leu Pro Pro Leu Gly Phe Leu 
                885                 890                 895     


Lys Val Pro Ile Trp Trp Tyr Gln Leu Gln Gly Pro Ser Gly His Trp 
            900                 905                 910         


Glu Ser His Gln Asp Gln Thr Asn Cys Thr Ser Ser Trp Gly Arg Val 
        915                 920                 925             


Trp Arg Ala Thr Ser Ser Gln Gly Ala Ser Gly Asn Glu Pro Ala Gln 
    930                 935                 940                 


Val Ser Leu Leu Tyr Leu Gly Asp Ile Glu Ile Ser Glu Asp Ala Thr 
945                 950                 955                 960 


Leu Ala Glu Leu Lys Ser Gln Ala Met Thr Leu Pro Pro Phe Leu Glu 
                965                 970                 975     


Phe Gly Val Pro Ser Pro Ala His Leu Arg Ala Trp Thr Val Glu Arg 
            980                 985                 990         


Lys Arg Pro Gly Arg Leu Leu Arg  Thr Asp Arg Gln Pro  Leu Arg Glu 
        995                 1000                 1005             


Tyr Lys  Leu Gly Arg Arg Ile  Glu Ile Cys Leu Glu  Pro Leu Gln 
    1010                 1015                 1020             


Lys Gly  Glu Asn Leu Gly Pro  Gln Asp Val Leu Leu  Arg Thr Gln 
    1025                 1030                 1035             


Val Arg  Ile Pro Gly Glu Arg  Thr Tyr Ala Pro Ala  Leu Asp Leu 
    1040                 1045                 1050             


Val Trp  Asn Ala Ala Gln Gly  Gly Thr Ala Gly Ser  Leu Arg Gln 
    1055                 1060                 1065             


Arg Val  Ala Asp Phe Tyr Arg  Leu Pro Val Glu Lys  Ile Glu Ile 
    1070                 1075                 1080             


Ala Lys  Tyr Phe Pro Glu Lys  Phe Glu Trp Leu Pro  Ile Ser Ser 
    1085                 1090                 1095             


Trp Asn  Gln Gln Ile Thr Lys  Arg Lys Lys Lys Lys  Lys Gln Asp 
    1100                 1105                 1110             


Tyr Leu  Gln Gly Ala Pro Tyr  Tyr Leu Lys Asp Gly  Asp Thr Ile 
    1115                 1120                 1125             


Gly Val  Lys Asn Leu Leu Ile  Asp Asp Asp Asp Asp  Phe Ser Thr 
    1130                 1135                 1140             


Ile Arg  Asp Asp Thr Gly Lys  Glu Lys Gln Lys Gln  Arg Ala Leu 
    1145                 1150                 1155             


Gly Arg  Arg Lys Ser Gln 
    1160                 


<210> 119
<211> 311
<212> PRT
<213> Homo sapiens

<400> 119
Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys Ala Val 
            20                  25                  30          


Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val Pro Leu 
        35                  40                  45              


Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys Pro Val 
    50                  55                  60                  


Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu Asp Ser 
65                  70                  75                  80  


Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu Asp Asn 
                85                  90                  95      


Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile Pro Lys 
            100                 105                 110         


Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu Val Asp 
        115                 120                 125             


Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu Ser Ile 
    130                 135                 140                 


Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val Ala Val 
145                 150                 155                 160 


Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His Gly Leu 
                165                 170                 175     


Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro Val Leu 
            180                 185                 190         


His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp Gln Asn 
        195                 200                 205             


Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro Leu Asp 
    210                 215                 220                 


Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr Ile Leu 
225                 230                 235                 240 


His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His Tyr Val 
                245                 250                 255     


Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe Asp Asp 
            260                 265                 270         


Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His Asn Tyr 
        275                 280                 285             


Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn Ala Tyr 
    290                 295                 300                 


Met Leu Val Tyr Ile Arg Glu 
305                 310     


<210> 120
<211> 344
<212> PRT
<213> Homo sapiens

<400> 120
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Ala Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 121
<211> 344
<212> PRT
<213> Homo sapiens

<400> 121
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Leu Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 122
<211> 344
<212> PRT
<213> Homo sapiens

<400> 122
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Lys Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Phe Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Ile Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Arg Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp Arg His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Asn Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Pro 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Ser Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Val 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 123
<211> 307
<212> PRT
<213> Homo sapiens

<400> 123
Trp Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys Cys Leu Asn 
1               5                   10                  15      


Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Ala Arg Ile Leu 
            20                  25                  30          


Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg Arg Ser Val 
        35                  40                  45              


Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp Ser Arg Gln 
    50                  55                  60                  


Lys Ala Val Trp Pro Leu Glu Leu Ala Tyr Cys Leu Gln Lys Tyr Asn 
65                  70                  75                  80  


Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr Leu Lys Leu 
                85                  90                  95      


Trp Asn Leu Ile Lys Asp Gln Ile Ala Asp Val His Leu Val Glu Arg 
            100                 105                 110         


Leu Gln Ala Leu Tyr Met Ile Arg Met Lys Asp Ser Leu Ile Cys Leu 
        115                 120                 125             


Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu Thr Leu Arg 
    130                 135                 140                 


Leu Ser Phe Phe Asp Val Asp Ser Lys Pro Leu Lys Thr Leu Glu Asp 
145                 150                 155                 160 


Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser Lys Ser Lys 
                165                 170                 175     


Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys Gln Val Leu 
            180                 185                 190         


Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu Met Arg Phe 
        195                 200                 205             


Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser Leu Tyr Phe 
    210                 215                 220                 


Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys Arg Glu Ser 
225                 230                 235                 240 


Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu Phe Ala Val 
                245                 250                 255     


Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys Val Tyr Ile 
            260                 265                 270         


Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp Ser Asn Ile 
        275                 280                 285             


Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly Asn Pro Asn 
    290                 295                 300                 


Tyr His Trp 
305         


<210> 124
<211> 511
<212> PRT
<213> Homo sapiens

<400> 124
Ser Glu Thr Gly Lys Thr Gly Leu Ile Asn Leu Gly Asn Thr Cys Tyr 
1               5                   10                  15      


Met Asn Ser Val Ile Gln Ala Leu Phe Met Ala Thr Asp Phe Arg Arg 
            20                  25                  30          


Gln Val Leu Ser Leu Asn Leu Asn Gly Cys Asn Ser Leu Met Lys Lys 
        35                  40                  45              


Leu Gln His Leu Phe Ala Phe Leu Ala His Thr Gln Arg Glu Ala Tyr 
    50                  55                  60                  


Ala Pro Arg Ile Phe Phe Glu Ala Ser Arg Pro Pro Trp Phe Thr Pro 
65                  70                  75                  80  


Arg Ser Gln Gln Asp Cys Ser Glu Tyr Leu Arg Phe Leu Leu Asp Arg 
                85                  90                  95      


Leu His Glu Glu Glu Lys Ile Leu Lys Val Gln Ala Ser His Lys Pro 
            100                 105                 110         


Ser Glu Ile Leu Glu Cys Ser Glu Thr Ser Leu Gln Glu Val Ala Ser 
        115                 120                 125             


Lys Ala Ala Val Leu Thr Glu Thr Pro Arg Thr Ser Asp Gly Glu Lys 
    130                 135                 140                 


Thr Leu Ile Glu Lys Met Phe Gly Gly Lys Leu Arg Thr His Ile Arg 
145                 150                 155                 160 


Cys Leu Asn Cys Arg Ser Thr Ser Gln Lys Val Glu Ala Phe Thr Asp 
                165                 170                 175     


Leu Ser Leu Ala Phe Cys Pro Ser Ser Ser Leu Glu Asn Met Ser Val 
            180                 185                 190         


Gln Asp Pro Ala Ser Ser Pro Ser Ile Gln Asp Gly Gly Leu Met Gln 
        195                 200                 205             


Ala Ser Val Pro Gly Pro Ser Glu Glu Pro Val Val Tyr Asn Pro Thr 
    210                 215                 220                 


Thr Ala Ala Phe Ile Cys Asp Ser Leu Val Asn Glu Lys Thr Ile Gly 
225                 230                 235                 240 


Ser Pro Pro Asn Glu Phe Tyr Cys Ser Glu Asn Thr Ser Val Pro Asn 
                245                 250                 255     


Glu Ser Asn Lys Ile Leu Val Asn Lys Asp Val Pro Gln Lys Pro Gly 
            260                 265                 270         


Gly Glu Thr Thr Pro Ser Val Thr Asp Leu Leu Asn Tyr Phe Leu Ala 
        275                 280                 285             


Pro Glu Ile Leu Thr Gly Asp Asn Gln Tyr Tyr Cys Glu Asn Cys Ala 
    290                 295                 300                 


Ser Leu Gln Asn Ala Glu Lys Thr Met Gln Ile Thr Glu Glu Pro Glu 
305                 310                 315                 320 


Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Tyr Asp Gln Lys Tyr His 
                325                 330                 335     


Val Arg Arg Lys Ile Leu Asp Asn Val Ser Leu Pro Leu Val Leu Glu 
            340                 345                 350         


Leu Pro Val Lys Arg Ile Thr Ser Phe Ser Ser Leu Ser Glu Ser Trp 
        355                 360                 365             


Ser Val Asp Val Asp Phe Thr Asp Leu Ser Glu Asn Leu Ala Lys Lys 
    370                 375                 380                 


Leu Lys Pro Ser Gly Thr Asp Glu Ala Ser Cys Thr Lys Leu Val Pro 
385                 390                 395                 400 


Tyr Leu Leu Ser Ser Val Val Val His Ser Gly Ile Ser Ser Glu Ser 
                405                 410                 415     


Gly His Tyr Tyr Ser Tyr Ala Arg Asn Ile Thr Ser Thr Asp Ser Ser 
            420                 425                 430         


Tyr Gln Met Tyr His Gln Ser Glu Ala Leu Ala Leu Ala Ser Ser Gln 
        435                 440                 445             


Ser His Leu Leu Gly Arg Asp Ser Pro Ser Ala Val Phe Glu Gln Asp 
    450                 455                 460                 


Leu Glu Asn Lys Glu Met Ser Lys Glu Trp Phe Leu Phe Asn Asp Ser 
465                 470                 475                 480 


Arg Val Thr Phe Thr Ser Phe Gln Ser Val Gln Lys Ile Thr Ser Arg 
                485                 490                 495     


Phe Pro Lys Asp Thr Ala Tyr Val Leu Leu Tyr Lys Lys Gln His 
            500                 505                 510     


<210> 125
<211> 616
<212> PRT
<213> Homo sapiens

<400> 125
Arg Pro Pro Gly Ala Gln Gly Leu Lys Asn His Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Val Val Gln Cys Leu Ser Asn Thr Asp Leu Leu Ala Glu 
            20                  25                  30          


Phe Leu Ala Leu Gly Arg Tyr Arg Ala Ala Pro Gly Arg Ala Glu Val 
        35                  40                  45              


Thr Glu Gln Leu Ala Ala Leu Val Arg Ala Leu Trp Thr Arg Glu Tyr 
    50                  55                  60                  


Thr Pro Gln Leu Ser Ala Glu Phe Lys Asn Ala Val Ser Lys Tyr Gly 
65                  70                  75                  80  


Ser Gln Phe Gln Gly Asn Ser Gln His Asp Ala Leu Glu Phe Leu Leu 
                85                  90                  95      


Trp Leu Leu Asp Arg Val His Glu Asp Leu Glu Gly Ser Ser Arg Gly 
            100                 105                 110         


Pro Val Ser Glu Lys Leu Pro Pro Glu Ala Thr Lys Thr Ser Glu Asn 
        115                 120                 125             


Cys Leu Ser Pro Ser Ala Gln Leu Pro Leu Gly Gln Ser Phe Val Gln 
    130                 135                 140                 


Ser His Phe Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys 
145                 150                 155                 160 


Leu Lys Gln Ser Asn Thr Phe Asp Pro Phe Leu Cys Val Ser Leu Pro 
                165                 170                 175     


Ile Pro Leu Arg Gln Thr Arg Phe Leu Ser Val Thr Leu Val Phe Pro 
            180                 185                 190         


Ser Lys Ser Gln Arg Phe Leu Arg Val Gly Leu Ala Val Pro Ile Leu 
        195                 200                 205             


Ser Thr Val Ala Ala Leu Arg Lys Met Val Ala Glu Glu Gly Gly Val 
    210                 215                 220                 


Pro Ala Asp Glu Val Ile Leu Val Glu Leu Tyr Pro Ser Gly Phe Gln 
225                 230                 235                 240 


Arg Ser Phe Phe Asp Glu Glu Asp Leu Asn Thr Ile Ala Glu Gly Asp 
                245                 250                 255     


Asn Val Tyr Ala Phe Gln Val Pro Pro Ser Pro Ser Gln Gly Thr Leu 
            260                 265                 270         


Ser Ala His Pro Leu Gly Leu Ser Ala Ser Pro Arg Leu Ala Ala Arg 
        275                 280                 285             


Glu Gly Gln Arg Phe Ser Leu Ser Leu His Ser Glu Ser Lys Val Leu 
    290                 295                 300                 


Ile Leu Phe Cys Asn Leu Val Gly Ser Gly Gln Gln Ala Ser Arg Phe 
305                 310                 315                 320 


Gly Pro Pro Phe Leu Ile Arg Glu Asp Arg Ala Val Ser Trp Ala Gln 
                325                 330                 335     


Leu Gln Gln Ser Ile Leu Ser Lys Val Arg His Leu Met Lys Ser Glu 
            340                 345                 350         


Ala Pro Val Gln Asn Leu Gly Ser Leu Phe Ser Ile Arg Val Val Gly 
        355                 360                 365             


Leu Ser Val Ala Cys Ser Tyr Leu Ser Pro Lys Asp Ser Arg Pro Leu 
    370                 375                 380                 


Cys His Trp Ala Val Asp Arg Val Leu His Leu Arg Arg Pro Gly Gly 
385                 390                 395                 400 


Pro Pro His Val Lys Leu Ala Val Glu Trp Asp Ser Ser Val Lys Glu 
                405                 410                 415     


Arg Leu Phe Gly Ser Leu Gln Glu Glu Arg Ala Gln Asp Ala Asp Ser 
            420                 425                 430         


Val Trp Gln Gln Gln Gln Ala His Gln Gln His Ser Cys Thr Leu Asp 
        435                 440                 445             


Glu Cys Phe Gln Phe Tyr Thr Lys Glu Glu Gln Leu Ala Gln Asp Asp 
    450                 455                 460                 


Ala Trp Lys Cys Pro His Cys Gln Val Leu Gln Gln Gly Met Val Lys 
465                 470                 475                 480 


Leu Ser Leu Trp Thr Leu Pro Asp Ile Leu Ile Ile His Leu Lys Arg 
                485                 490                 495     


Phe Cys Gln Val Gly Glu Arg Arg Asn Lys Leu Ser Thr Leu Val Lys 
            500                 505                 510         


Phe Pro Leu Ser Gly Leu Asn Met Ala Pro His Val Ala Gln Arg Ser 
        515                 520                 525             


Thr Ser Pro Glu Ala Gly Leu Gly Pro Trp Pro Ser Trp Lys Gln Pro 
    530                 535                 540                 


Asp Cys Leu Pro Thr Ser Tyr Pro Leu Asp Phe Leu Tyr Asp Leu Tyr 
545                 550                 555                 560 


Ala Val Cys Asn His His Gly Asn Leu Gln Gly Gly His Tyr Thr Ala 
                565                 570                 575     


Tyr Cys Arg Asn Ser Leu Asp Gly Gln Trp Tyr Ser Tyr Asp Asp Ser 
            580                 585                 590         


Thr Val Glu Pro Leu Arg Glu Asp Glu Val Asn Thr Arg Gly Ala Tyr 
        595                 600                 605             


Ile Leu Phe Tyr Gln Lys Arg Asn 
    610                 615     


<210> 126
<211> 339
<212> PRT
<213> Homo sapiens

<400> 126
Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp 
            20                  25                  30          


Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn 
        35                  40                  45              


Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile 
    50                  55                  60                  


Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr 
65                  70                  75                  80  


Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp 
                85                  90                  95      


Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val 
            100                 105                 110         


Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His 
        115                 120                 125             


Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu 
    130                 135                 140                 


Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser 
145                 150                 155                 160 


Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro 
                165                 170                 175     


Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val 
            180                 185                 190         


Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp 
        195                 200                 205             


Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys 
    210                 215                 220                 


Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His 
225                 230                 235                 240 


Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr 
                245                 250                 255     


Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser 
            260                 265                 270         


Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His 
        275                 280                 285             


Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro 
    290                 295                 300                 


Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met 
305                 310                 315                 320 


Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu 
                325                 330                 335     


Leu Ala Ser 
            


<210> 127
<211> 628
<212> PRT
<213> Homo sapiens

<400> 127
Leu Ser Val Arg Gly Ile Thr Asn Leu Gly Asn Thr Cys Phe Phe Asn 
1               5                   10                  15      


Ala Val Met Gln Asn Leu Ala Gln Thr Tyr Thr Leu Thr Asp Leu Met 
            20                  25                  30          


Asn Glu Ile Lys Glu Ser Ser Thr Lys Leu Lys Ile Phe Pro Ser Ser 
        35                  40                  45              


Asp Ser Gln Leu Asp Pro Leu Val Val Glu Leu Ser Arg Pro Gly Pro 
    50                  55                  60                  


Leu Thr Ser Ala Leu Phe Leu Phe Leu His Ser Met Lys Glu Thr Glu 
65                  70                  75                  80  


Lys Gly Pro Leu Ser Pro Lys Val Leu Phe Asn Gln Leu Cys Gln Lys 
                85                  90                  95      


Ala Pro Arg Phe Lys Asp Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu 
            100                 105                 110         


His Tyr Leu Leu Asp Ala Val Arg Thr Glu Glu Thr Lys Arg Ile Gln 
        115                 120                 125             


Ala Ser Ile Leu Lys Ala Phe Asn Asn Pro Thr Thr Lys Thr Ala Asp 
    130                 135                 140                 


Asp Glu Thr Arg Lys Lys Val Lys Ala Tyr Gly Lys Glu Gly Val Lys 
145                 150                 155                 160 


Met Asn Phe Ile Asp Arg Ile Phe Ile Gly Glu Leu Thr Ser Thr Val 
                165                 170                 175     


Met Cys Glu Glu Cys Ala Asn Ile Ser Thr Val Lys Asp Pro Phe Ile 
            180                 185                 190         


Asp Ile Ser Leu Pro Ile Ile Glu Glu Arg Val Ser Lys Pro Leu Leu 
        195                 200                 205             


Trp Gly Arg Met Asn Lys Tyr Arg Ser Leu Arg Glu Thr Asp His Asp 
    210                 215                 220                 


Arg Tyr Ser Gly Asn Val Thr Ile Glu Asn Ile His Gln Pro Arg Ala 
225                 230                 235                 240 


Ala Lys Lys His Ser Ser Ser Lys Asp Lys Ser Gln Leu Ile His Asp 
                245                 250                 255     


Arg Lys Cys Ile Arg Lys Leu Ser Ser Gly Glu Thr Val Thr Tyr Gln 
            260                 265                 270         


Lys Asn Glu Asn Leu Glu Met Asn Gly Asp Ser Leu Met Phe Ala Ser 
        275                 280                 285             


Leu Met Asn Ser Glu Ser Arg Leu Asn Glu Ser Pro Thr Asp Asp Ser 
    290                 295                 300                 


Glu Lys Glu Ala Ser His Ser Glu Ser Asn Val Asp Ala Asp Ser Glu 
305                 310                 315                 320 


Pro Ser Glu Ser Glu Ser Ala Ser Lys Gln Thr Gly Leu Phe Arg Ser 
                325                 330                 335     


Ser Ser Gly Ser Gly Val Gln Pro Asp Gly Pro Leu Tyr Pro Leu Ser 
            340                 345                 350         


Ala Gly Lys Leu Leu Tyr Thr Lys Glu Thr Asp Ser Gly Asp Lys Glu 
        355                 360                 365             


Met Ala Glu Ala Ile Ser Glu Leu Arg Leu Ser Ser Thr Val Thr Gly 
    370                 375                 380                 


Asp Gln Asp Phe Asp Arg Glu Asn Gln Pro Leu Asn Ile Ser Asn Asn 
385                 390                 395                 400 


Leu Cys Phe Leu Glu Gly Lys His Leu Arg Ser Tyr Ser Pro Gln Asn 
                405                 410                 415     


Ala Phe Gln Thr Leu Ser Gln Ser Tyr Ile Thr Thr Ser Lys Glu Cys 
            420                 425                 430         


Ser Ile Gln Ser Cys Leu Tyr Gln Phe Thr Ser Met Glu Leu Leu Met 
        435                 440                 445             


Gly Asn Asn Lys Leu Leu Cys Glu Asn Cys Thr Lys Asn Lys Gln Lys 
    450                 455                 460                 


Tyr Gln Glu Glu Thr Ser Phe Ala Glu Lys Lys Val Glu Gly Val Tyr 
465                 470                 475                 480 


Thr Asn Ala Arg Lys Gln Leu Leu Ile Ser Ala Val Pro Ala Val Leu 
                485                 490                 495     


Ile Leu His Leu Lys Arg Phe His Gln Ala Gly Leu Ser Leu Arg Lys 
            500                 505                 510         


Val Asn Arg His Val Asp Phe Pro Leu Met Leu Asp Leu Ala Pro Phe 
        515                 520                 525             


Cys Ser Ala Thr Cys Lys Asn Ala Ser Val Gly Asp Lys Val Leu Tyr 
    530                 535                 540                 


Gly Leu Tyr Gly Ile Val Glu His Ser Gly Ser Met Arg Glu Gly His 
545                 550                 555                 560 


Tyr Thr Ala Tyr Val Lys Val Arg Thr Pro Ser Arg Lys Leu Ser Glu 
                565                 570                 575     


His Asn Thr Lys Lys Lys Asn Val Pro Gly Leu Lys Ala Ala Asp Asn 
            580                 585                 590         


Glu Ser Ala Gly Gln Trp Val His Val Ser Asp Thr Tyr Leu Gln Val 
        595                 600                 605             


Val Pro Glu Ser Arg Ala Leu Ser Ala Gln Ala Tyr Leu Leu Phe Tyr 
    610                 615                 620                 


Glu Arg Val Leu 
625             


<210> 128
<211> 876
<212> PRT
<213> Homo sapiens

<400> 128
Thr Glu Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln 
            20                  25                  30          


Tyr Phe Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro 
        35                  40                  45              


Ile Gly Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln 
    50                  55                  60                  


Glu Leu Trp Ser Gly Thr Gln Lys Asn Val Ala Pro Leu Lys Leu Arg 
65                  70                  75                  80  


Trp Thr Ile Ala Lys Tyr Ala Pro Arg Phe Asn Gly Phe Gln Gln Gln 
                85                  90                  95      


Asp Ser Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp 
            100                 105                 110         


Leu Asn Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp 
        115                 120                 125             


Gly Arg Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu 
    130                 135                 140                 


Arg Arg Asn Arg Ser Ile Val Val Asp Leu Phe His Gly Gln Leu Arg 
145                 150                 155                 160 


Ser Gln Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp 
                165                 170                 175     


Pro Phe Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met His 
            180                 185                 190         


Leu Glu Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr 
        195                 200                 205             


Gly Leu Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln 
    210                 215                 220                 


Leu Ser Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu 
225                 230                 235                 240 


Val His Gly Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val 
                245                 250                 255     


Arg Leu Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro 
            260                 265                 270         


Val Ser Pro Ile Ser Ala Ser Ser Pro Thr Gln Thr Asp Phe Ser Ser 
        275                 280                 285             


Ser Pro Ser Thr Asn Glu Met Phe Thr Leu Thr Thr Asn Gly Asp Leu 
    290                 295                 300                 


Pro Arg Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro 
305                 310                 315                 320 


Cys Gly Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met 
                325                 330                 335     


Pro Ser Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His 
            340                 345                 350         


Arg Lys Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Ser Gln Lys Asn 
        355                 360                 365             


Arg Pro Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His 
    370                 375                 380                 


Thr Arg Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Arg 
385                 390                 395                 400 


Leu Ala Ser Pro Leu Pro Pro Gln Glu Ala Ser Asn His Ala Gln Asp 
                405                 410                 415     


Cys Asp Asp Ser Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val 
            420                 425                 430         


Gln Lys Asp Gly Asn Ser Cys Ala Trp Cys Pro Trp Tyr Arg Phe Cys 
        435                 440                 445             


Arg Gly Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn 
    450                 455                 460                 


Ala Tyr Ile Ala Val Asp Trp Asp Pro Thr Ala Leu His Leu Arg Tyr 
465                 470                 475                 480 


Gln Thr Ser Gln Glu Arg Val Val Asp Glu His Glu Ser Val Glu Gln 
                485                 490                 495     


Ser Arg Arg Ala Gln Ala Glu Pro Ile Asn Leu Asp Ser Cys Leu Arg 
            500                 505                 510         


Ala Phe Thr Ser Glu Glu Glu Leu Gly Glu Asn Glu Met Tyr Tyr Cys 
        515                 520                 525             


Ser Lys Cys Lys Thr His Cys Leu Ala Thr Lys Lys Leu Asp Leu Trp 
    530                 535                 540                 


Arg Leu Pro Pro Ile Leu Ile Ile His Leu Lys Arg Phe Gln Phe Val 
545                 550                 555                 560 


Asn Gly Arg Trp Ile Lys Ser Gln Lys Ile Val Lys Phe Pro Arg Glu 
                565                 570                 575     


Ser Phe Asp Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu Cys 
            580                 585                 590         


Gln His Lys Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Glu Pro Arg 
        595                 600                 605             


Ile Leu Ala Arg Glu Val Lys Lys Val Asp Ala Gln Ser Ser Ala Gly 
    610                 615                 620                 


Glu Glu Asp Val Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn 
625                 630                 635                 640 


Ile Ile Ser Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser Gly 
                645                 650                 655     


Thr Ser Cys Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Ser Pro Arg 
            660                 665                 670         


Thr Leu Gly Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly Ser 
        675                 680                 685             


Lys Asn Lys Leu Ser Ser Ser Lys Glu Asn Leu Asp Ala Ser Lys Glu 
    690                 695                 700                 


Asn Gly Ala Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser Arg Gly 
705                 710                 715                 720 


His Val Leu Gly Gly Ser Gln Pro Glu Leu Val Thr Pro Gln Asp His 
                725                 730                 735     


Glu Val Ala Leu Ala Asn Gly Phe Leu Tyr Glu His Glu Ala Cys Gly 
            740                 745                 750         


Asn Gly Tyr Ser Asn Gly Gln Leu Gly Asn His Ser Glu Glu Asp Ser 
        755                 760                 765             


Thr Asp Asp Gln Arg Glu Asp Thr Arg Ile Lys Pro Ile Tyr Asn Leu 
    770                 775                 780                 


Tyr Ala Ile Ser Cys His Ser Gly Ile Leu Gly Gly Gly His Tyr Val 
785                 790                 795                 800 


Thr Tyr Ala Lys Asn Pro Asn Cys Lys Trp Tyr Cys Tyr Asn Asp Ser 
                805                 810                 815     


Ser Cys Lys Glu Leu His Pro Asp Glu Ile Asp Thr Asp Ser Ala Tyr 
            820                 825                 830         


Ile Leu Phe Tyr Glu Gln Gln Gly Ile Asp Tyr Ala Gln Phe Leu Pro 
        835                 840                 845             


Lys Thr Asp Gly Lys Lys Met Ala Asp Thr Ser Ser Met Asp Glu Asp 
    850                 855                 860                 


Phe Glu Ser Asp Tyr Lys Lys Tyr Cys Val Leu Gln 
865                 870                 875     


<210> 129
<211> 300
<212> PRT
<213> Homo sapiens

<400> 129
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 130
<211> 313
<212> PRT
<213> Homo sapiens

<400> 130
Arg Val Gly Ala Gly Leu Gln Asn Leu Gly Asn Thr Cys Phe Ala Asn 
1               5                   10                  15      


Ala Ala Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser His Glu His Ser Lys Thr Cys His Ala Glu Gly Phe Cys Met 
        35                  40                  45              


Met Cys Thr Met Gln Ala His Ile Thr Gln Ala Leu Ser Asn Pro Gly 
    50                  55                  60                  


Asp Val Ile Lys Pro Met Phe Val Ile Asn Glu Met Arg Arg Ile Ala 
65                  70                  75                  80  


Arg His Phe Arg Phe Gly Asn Gln Glu Asp Ala His Glu Phe Leu Gln 
                85                  90                  95      


Tyr Thr Val Asp Ala Met Gln Lys Ala Cys Leu Asn Gly Ser Asn Lys 
            100                 105                 110         


Leu Asp Arg His Thr Gln Ala Thr Thr Leu Val Cys Gln Ile Phe Gly 
        115                 120                 125             


Gly Tyr Leu Arg Ser Arg Val Lys Cys Leu Asn Cys Lys Gly Val Ser 
    130                 135                 140                 


Asp Thr Phe Asp Pro Tyr Leu Asp Ile Thr Leu Glu Ile Lys Ala Ala 
145                 150                 155                 160 


Gln Ser Val Asn Lys Ala Leu Glu Gln Phe Val Lys Pro Glu Gln Leu 
                165                 170                 175     


Asp Gly Glu Asn Ser Tyr Lys Cys Ser Lys Cys Lys Lys Met Val Pro 
            180                 185                 190         


Ala Ser Lys Arg Phe Thr Ile His Arg Ser Ser Asn Val Leu Thr Leu 
        195                 200                 205             


Ser Leu Lys Arg Phe Ala Asn Phe Thr Gly Gly Lys Ile Ala Lys Asp 
    210                 215                 220                 


Val Lys Tyr Pro Glu Tyr Leu Asp Ile Arg Pro Tyr Met Ser Gln Pro 
225                 230                 235                 240 


Asn Gly Glu Pro Ile Val Tyr Val Leu Tyr Ala Val Leu Val His Thr 
                245                 250                 255     


Gly Phe Asn Cys His Ala Gly His Tyr Phe Cys Tyr Ile Lys Ala Ser 
            260                 265                 270         


Asn Gly Leu Trp Tyr Gln Met Asn Asp Ser Ile Val Ser Thr Ser Asp 
        275                 280                 285             


Ile Arg Ser Val Leu Ser Gln Gln Ala Tyr Val Leu Phe Tyr Ile Arg 
    290                 295                 300                 


Ser His Asp Val Lys Asn Gly Gly Glu 
305                 310             


<210> 131
<211> 344
<212> PRT
<213> Homo sapiens

<400> 131
Ala Val Gly Ala Gly Leu Gln Lys Ile Gly Asn Thr Phe Tyr Val Asn 
1               5                   10                  15      


Val Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ser Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu Asp Ser Gln Thr Cys His Leu His Lys Cys Cys Met 
        35                  40                  45              


Phe Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Val Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Glu Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Leu Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Ala Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Tyr Leu His Cys His Gly Val Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Lys Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Lys Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu Pro Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Lys Cys 
    210                 215                 220                 


Arg Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Gly Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Val Pro Glu Leu 
            340                 


<210> 132
<211> 344
<212> PRT
<213> Homo sapiens

<400> 132
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 133
<211> 533
<212> PRT
<213> Homo sapiens

<400> 133
Tyr Gly Pro Gly Tyr Thr Gly Leu Lys Asn Leu Gly Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Ser Ser Val Met Gln Ala Ile Phe Ser Ile Pro Glu Phe Gln Arg 
            20                  25                  30          


Ala Tyr Val Gly Asn Leu Pro Arg Ile Phe Asp Tyr Ser Pro Leu Asp 
        35                  40                  45              


Pro Thr Gln Asp Phe Asn Thr Gln Met Thr Lys Leu Gly His Gly Leu 
    50                  55                  60                  


Leu Ser Gly Gln Tyr Ser Lys Pro Pro Val Lys Ser Glu Leu Ile Glu 
65                  70                  75                  80  


Gln Val Met Lys Glu Glu His Lys Pro Gln Gln Asn Gly Ile Ser Pro 
                85                  90                  95      


Arg Met Phe Lys Ala Phe Val Ser Lys Ser His Pro Glu Phe Ser Ser 
            100                 105                 110         


Asn Arg Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Val Asn Leu 
        115                 120                 125             


Val Glu Arg Asn Arg Ile Gly Ser Glu Asn Pro Ser Asp Val Phe Arg 
    130                 135                 140                 


Phe Leu Val Glu Glu Arg Ile Gln Cys Cys Gln Thr Arg Lys Val Arg 
145                 150                 155                 160 


Tyr Thr Glu Arg Val Asp Tyr Leu Met Gln Leu Pro Val Ala Met Glu 
                165                 170                 175     


Ala Ala Thr Asn Lys Asp Glu Leu Ile Ala Tyr Glu Leu Thr Arg Arg 
            180                 185                 190         


Glu Ala Glu Ala Asn Arg Arg Pro Leu Pro Glu Leu Val Arg Ala Lys 
        195                 200                 205             


Ile Pro Phe Ser Ala Cys Leu Gln Ala Phe Ser Glu Pro Glu Asn Val 
    210                 215                 220                 


Asp Asp Phe Trp Ser Ser Ala Leu Gln Ala Lys Ser Ala Gly Val Lys 
225                 230                 235                 240 


Thr Ser Arg Phe Ala Ser Phe Pro Glu Tyr Leu Val Val Gln Ile Lys 
                245                 250                 255     


Lys Phe Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Phe Asp Val Ser 
            260                 265                 270         


Ile Asp Met Pro Asp Leu Leu Asp Ile Asn His Leu Arg Ala Arg Gly 
        275                 280                 285             


Leu Gln Pro Gly Glu Glu Glu Leu Pro Asp Ile Ser Pro Pro Ile Val 
    290                 295                 300                 


Ile Pro Asp Asp Ser Lys Asp Arg Leu Met Asn Gln Leu Ile Asp Pro 
305                 310                 315                 320 


Ser Asp Ile Asp Glu Ser Ser Val Met Gln Leu Ala Glu Met Gly Phe 
                325                 330                 335     


Pro Leu Glu Ala Cys Arg Lys Ala Val Tyr Phe Thr Gly Asn Met Gly 
            340                 345                 350         


Ala Glu Val Ala Phe Asn Trp Ile Ile Val His Met Glu Glu Pro Asp 
        355                 360                 365             


Phe Ala Glu Pro Leu Thr Met Pro Gly Tyr Gly Gly Ala Ala Ser Ala 
    370                 375                 380                 


Gly Ala Ser Val Phe Gly Ala Ser Gly Leu Asp Asn Gln Pro Pro Glu 
385                 390                 395                 400 


Glu Ile Val Ala Ile Ile Thr Ser Met Gly Phe Gln Arg Asn Gln Ala 
                405                 410                 415     


Ile Gln Ala Leu Arg Ala Thr Asn Asn Asn Leu Glu Arg Ala Leu Asp 
            420                 425                 430         


Trp Ile Phe Ser His Pro Glu Phe Glu Glu Asp Ser Asp Phe Val Ile 
        435                 440                 445             


Glu Met Glu Asn Asn Ala Asn Ala Asn Ile Ile Ser Glu Ala Lys Pro 
    450                 455                 460                 


Glu Gly Pro Arg Val Lys Asp Gly Ser Gly Thr Tyr Glu Leu Phe Ala 
465                 470                 475                 480 


Phe Ile Ser His Met Gly Thr Ser Thr Met Ser Gly His Tyr Ile Cys 
                485                 490                 495     


His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr Asn Asp His Lys Val 
            500                 505                 510         


Cys Ala Ser Glu Arg Pro Pro Lys Asp Leu Gly Tyr Met Tyr Phe Tyr 
        515                 520                 525             


Arg Arg Ile Pro Ser 
    530             


<210> 134
<211> 629
<212> PRT
<213> Homo sapiens

<400> 134
Lys Gly Gln Pro Gly Ile Cys Gly Leu Thr Asn Leu Gly Asn Thr Cys 
1               5                   10                  15      


Phe Met Asn Ser Ala Leu Gln Cys Leu Ser Asn Val Pro Gln Leu Thr 
            20                  25                  30          


Glu Tyr Phe Leu Asn Asn Cys Tyr Leu Glu Glu Leu Asn Phe Arg Asn 
        35                  40                  45              


Pro Leu Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Asp Leu Val 
    50                  55                  60                  


Lys Gln Ala Trp Ser Gly His His Arg Ser Ile Val Pro His Val Phe 
65                  70                  75                  80  


Lys Asn Lys Val Gly His Phe Ala Ser Gln Phe Leu Gly Tyr Gln Gln 
                85                  90                  95      


His Asp Ser Gln Glu Leu Leu Ser Phe Leu Leu Asp Gly Leu His Glu 
            100                 105                 110         


Asp Leu Asn Arg Val Lys Lys Lys Glu Tyr Val Glu Leu Cys Asp Ala 
        115                 120                 125             


Ala Gly Arg Pro Asp Gln Glu Val Ala Gln Glu Ala Trp Gln Asn His 
    130                 135                 140                 


Lys Arg Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu Phe 
145                 150                 155                 160 


Lys Ser Thr Leu Val Cys Pro Asp Cys Gly Asn Val Ser Val Thr Phe 
                165                 170                 175     


Asp Pro Phe Cys Tyr Leu Ser Val Pro Leu Pro Ile Ser His Lys Arg 
            180                 185                 190         


Val Leu Glu Val Phe Phe Ile Pro Met Asp Pro Arg Arg Lys Pro Glu 
        195                 200                 205             


Gln His Arg Leu Val Val Pro Lys Lys Gly Lys Ile Ser Asp Leu Cys 
    210                 215                 220                 


Val Ala Leu Ser Lys His Thr Gly Ile Ser Pro Glu Arg Met Met Val 
225                 230                 235                 240 


Ala Asp Val Phe Ser His Arg Phe Tyr Lys Leu Tyr Gln Leu Glu Glu 
                245                 250                 255     


Pro Leu Ser Ser Ile Leu Asp Arg Asp Asp Ile Phe Val Tyr Glu Val 
            260                 265                 270         


Ser Gly Arg Ile Glu Ala Ile Glu Gly Ser Arg Glu Asp Ile Val Val 
        275                 280                 285             


Pro Val Tyr Leu Arg Glu Arg Thr Pro Ala Arg Asp Tyr Asn Asn Ser 
    290                 295                 300                 


Tyr Tyr Gly Leu Met Leu Phe Gly His Pro Leu Leu Val Ser Val Pro 
305                 310                 315                 320 


Arg Asp Arg Phe Thr Trp Glu Gly Leu Tyr Asn Val Leu Met Tyr Arg 
                325                 330                 335     


Leu Ser Arg Tyr Val Thr Lys Pro Asn Ser Asp Asp Glu Asp Asp Gly 
            340                 345                 350         


Asp Glu Lys Glu Asp Asp Glu Glu Asp Lys Asp Asp Val Pro Gly Pro 
        355                 360                 365             


Ser Thr Gly Gly Ser Leu Arg Asp Pro Glu Pro Glu Gln Ala Gly Pro 
    370                 375                 380                 


Ser Ser Gly Val Thr Asn Arg Cys Pro Phe Leu Leu Asp Asn Cys Leu 
385                 390                 395                 400 


Gly Thr Ser Gln Trp Pro Pro Arg Arg Arg Arg Lys Gln Leu Phe Thr 
                405                 410                 415     


Leu Gln Thr Val Asn Ser Asn Gly Thr Ser Asp Arg Thr Thr Ser Pro 
            420                 425                 430         


Glu Glu Val His Ala Gln Pro Tyr Ile Ala Ile Asp Trp Glu Pro Glu 
        435                 440                 445             


Met Lys Lys Arg Tyr Tyr Asp Glu Val Glu Ala Glu Gly Tyr Val Lys 
    450                 455                 460                 


His Asp Cys Val Gly Tyr Val Met Lys Lys Ala Pro Val Arg Leu Gln 
465                 470                 475                 480 


Glu Cys Ile Glu Leu Phe Thr Thr Val Glu Thr Leu Glu Lys Glu Asn 
                485                 490                 495     


Pro Trp Tyr Cys Pro Ser Cys Lys Gln His Gln Leu Ala Thr Lys Lys 
            500                 505                 510         


Leu Asp Leu Trp Met Leu Pro Glu Ile Leu Ile Ile His Leu Lys Arg 
        515                 520                 525             


Phe Ser Tyr Thr Lys Phe Ser Arg Glu Lys Leu Asp Thr Leu Val Glu 
    530                 535                 540                 


Phe Pro Ile Arg Asp Leu Asp Phe Ser Glu Phe Val Ile Gln Pro Gln 
545                 550                 555                 560 


Asn Glu Ser Asn Pro Glu Leu Tyr Lys Tyr Asp Leu Ile Ala Val Ser 
                565                 570                 575     


Asn His Tyr Gly Gly Met Arg Asp Gly His Tyr Thr Thr Phe Ala Cys 
            580                 585                 590         


Asn Lys Asp Ser Gly Gln Trp His Tyr Phe Asp Asp Asn Ser Val Ser 
        595                 600                 605             


Pro Val Asn Glu Asn Gln Ile Glu Ser Lys Ala Ala Tyr Val Leu Phe 
    610                 615                 620                 


Tyr Gln Arg Gln Asp 
625                 


<210> 135
<211> 300
<212> PRT
<213> Homo sapiens

<400> 135
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Cys Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Val Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Ile Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 136
<211> 387
<212> PRT
<213> Homo sapiens

<400> 136
Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu Leu 
            20                  25                  30          


Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly Glu 
        35                  40                  45              


Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe Asp 
    50                  55                  60                  


Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu Gln 
65                  70                  75                  80  


Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln Gly 
                85                  90                  95      


Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met Arg 
            100                 105                 110         


Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys Glu 
        115                 120                 125             


Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys Ser 
    130                 135                 140                 


Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys Cys 
145                 150                 155                 160 


Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln Leu 
                165                 170                 175     


Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr Gly 
            180                 185                 190         


Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr Leu 
        195                 200                 205             


Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu Pro 
    210                 215                 220                 


Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys Glu 
225                 230                 235                 240 


Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met Leu 
                245                 250                 255     


Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val Ser 
            260                 265                 270         


Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln Gln 
        275                 280                 285             


Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys Tyr 
    290                 295                 300                 


Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly Tyr 
305                 310                 315                 320 


Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser Ser 
                325                 330                 335     


Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile Lys 
            340                 345                 350         


Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu Arg 
        355                 360                 365             


Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr Gly 
    370                 375                 380                 


Pro Arg Arg 
385         


<210> 137
<211> 630
<212> PRT
<213> Homo sapiens

<400> 137
Ser His Ile Gln Pro Gly Leu Cys Gly Leu Gly Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Phe Met Asn Ser Ala Leu Gln Cys Leu Ser Asn Thr Ala Pro Leu 
            20                  25                  30          


Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu Ala Glu Ile Asn Arg Asp 
        35                  40                  45              


Asn Pro Leu Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Glu Leu 
    50                  55                  60                  


Ile Lys Gln Met Trp Ser Gly Arg Asp Ala His Val Ala Pro Arg Met 
65                  70                  75                  80  


Phe Lys Thr Gln Val Gly Arg Phe Ala Pro Gln Phe Ser Gly Tyr Gln 
                85                  90                  95      


Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His 
            100                 105                 110         


Glu Asp Leu Asn Arg Val Lys Lys Lys Pro Tyr Leu Glu Leu Lys Asp 
        115                 120                 125             


Ala Asn Gly Arg Pro Asp Ala Val Val Ala Lys Glu Ala Trp Glu Asn 
    130                 135                 140                 


His Arg Leu Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu 
145                 150                 155                 160 


Phe Lys Ser Thr Leu Val Cys Pro Glu Cys Ala Lys Val Ser Val Thr 
                165                 170                 175     


Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro Leu Pro Leu Lys Lys Asp 
            180                 185                 190         


Arg Val Met Glu Val Phe Leu Val Pro Ala Asp Pro His Cys Arg Pro 
        195                 200                 205             


Thr Gln Tyr Arg Val Thr Val Pro Leu Met Gly Ala Val Ser Asp Leu 
    210                 215                 220                 


Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile Ala Ala Glu Asn Met Val 
225                 230                 235                 240 


Val Ala Asp Val Tyr Asn His Arg Phe His Lys Ile Phe Gln Met Asp 
                245                 250                 255     


Glu Gly Leu Asn His Ile Met Pro Arg Asp Asp Ile Phe Val Tyr Glu 
            260                 265                 270         


Val Cys Ser Thr Ser Val Asp Gly Ser Glu Cys Val Thr Leu Pro Val 
        275                 280                 285             


Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser Ser Thr Ser Ser Ala Ser 
    290                 295                 300                 


Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser Val Pro Lys His Lys Leu 
305                 310                 315                 320 


Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys Asp Arg Ile Ser Arg Tyr 
                325                 330                 335     


Val Lys Gln Pro Leu Pro Asp Glu Phe Gly Ser Ser Pro Leu Glu Pro 
            340                 345                 350         


Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys Glu Gly Glu Asp Glu Glu 
        355                 360                 365             


Glu Met Glu His Gln Glu Glu Gly Lys Glu Gln Leu Ser Glu Thr Glu 
    370                 375                 380                 


Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp Pro Ser Glu Thr Thr Gln 
385                 390                 395                 400 


Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys Arg Leu Phe Thr Phe Ser 
                405                 410                 415     


Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile Asn Ser Leu Ala Ala Asp 
            420                 425                 430         


Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser Thr Leu Ala Met Asp Trp 
        435                 440                 445             


Asp Ser Glu Thr Arg Arg Leu Tyr Tyr Asp Glu Gln Glu Ser Glu Ala 
    450                 455                 460                 


Tyr Glu Lys His Val Ser Met Leu Gln Pro Gln Lys Lys Lys Lys Thr 
465                 470                 475                 480 


Thr Val Ala Leu Arg Asp Cys Ile Glu Leu Phe Thr Thr Met Glu Thr 
                485                 490                 495     


Leu Gly Glu His Asp Pro Trp Tyr Cys Pro Asn Cys Lys Lys His Gln 
            500                 505                 510         


Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser Leu Pro Lys Ile Leu Val 
        515                 520                 525             


Val His Leu Lys Arg Phe Ser Tyr Asn Arg Tyr Trp Arg Asp Lys Leu 
    530                 535                 540                 


Asp Thr Val Val Glu Phe Pro Ile Arg Gly Leu Asn Met Ser Glu Phe 
545                 550                 555                 560 


Val Cys Asn Leu Ser Ala Arg Pro Tyr Val Tyr Asp Leu Ile Ala Val 
                565                 570                 575     


Ser Asn His Tyr Gly Ala Met Gly Val Gly His Tyr Thr Ala Tyr Ala 
            580                 585                 590         


Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr Phe Asp Asp Ser Asn Val 
        595                 600                 605             


Ser Leu Ala Ser Glu Asp Gln Ile Val Thr Lys Ala Ala Tyr Val Leu 
    610                 615                 620                 


Phe Tyr Gln Arg Arg Asp 
625                 630 


<210> 138
<211> 595
<212> PRT
<213> Homo sapiens

<400> 138
Lys Ile Cys His Gly Leu Pro Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Val Leu Gln Ser Leu Leu Ser Ile Pro Ser Phe Ala Asp Asp Leu 
            20                  25                  30          


Leu Asn Gln Ser Phe Pro Trp Gly Lys Ile Pro Leu Asn Ala Leu Thr 
        35                  40                  45              


Met Cys Leu Ala Arg Leu Leu Phe Phe Lys Asp Thr Tyr Asn Ile Glu 
    50                  55                  60                  


Ile Lys Glu Met Leu Leu Leu Asn Leu Lys Lys Ala Ile Ser Ala Ala 
65                  70                  75                  80  


Ala Glu Ile Phe His Gly Asn Ala Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Ala His Cys Leu Asp Gln Leu Lys Asp Asn Met Glu Lys Leu Asn Thr 
            100                 105                 110         


Ile Trp Lys Pro Lys Ser Glu Phe Gly Glu Asp Asn Phe Pro Lys Gln 
        115                 120                 125             


Val Phe Ala Asp Asp Pro Asp Thr Ser Gly Phe Ser Cys Pro Val Ile 
    130                 135                 140                 


Thr Asn Phe Glu Leu Glu Leu Leu His Ser Ile Ala Cys Lys Ala Cys 
145                 150                 155                 160 


Gly Gln Val Ile Leu Lys Thr Glu Leu Asn Asn Tyr Leu Ser Ile Asn 
                165                 170                 175     


Leu Pro Gln Arg Ile Lys Ala His Pro Ser Ser Ile Gln Ser Thr Phe 
            180                 185                 190         


Asp Leu Phe Phe Gly Ala Glu Glu Leu Glu Tyr Lys Cys Ala Lys Cys 
        195                 200                 205             


Glu His Lys Thr Ser Val Gly Val His Ser Phe Ser Arg Leu Pro Arg 
    210                 215                 220                 


Ile Leu Ile Val His Leu Lys Arg Tyr Ser Leu Asn Glu Phe Cys Ala 
225                 230                 235                 240 


Leu Lys Lys Asn Asp Gln Glu Val Ile Ile Ser Lys Tyr Leu Lys Val 
                245                 250                 255     


Ser Ser His Cys Asn Glu Gly Thr Arg Pro Pro Leu Pro Leu Ser Glu 
            260                 265                 270         


Asp Gly Glu Ile Thr Asp Phe Gln Leu Leu Lys Val Ile Arg Lys Met 
        275                 280                 285             


Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys Glu Ser Lys 
    290                 295                 300                 


Asp Ile Leu Ala Pro His Ile Gly Ser Asp Lys Glu Ser Glu Gln Lys 
305                 310                 315                 320 


Lys Gly Gln Thr Val Phe Lys Gly Ala Ser Arg Arg Gln Gln Gln Lys 
                325                 330                 335     


Tyr Leu Gly Lys Asn Ser Lys Pro Asn Glu Leu Glu Ser Val Tyr Ser 
            340                 345                 350         


Gly Asp Arg Ala Phe Ile Glu Lys Glu Pro Leu Ala His Leu Met Thr 
        355                 360                 365             


Tyr Leu Glu Asp Thr Ser Leu Cys Gln Phe His Lys Ala Gly Gly Lys 
    370                 375                 380                 


Pro Ala Ser Ser Pro Gly Thr Pro Leu Ser Lys Val Asp Phe Gln Thr 
385                 390                 395                 400 


Val Pro Glu Asn Pro Lys Arg Lys Lys Tyr Val Lys Thr Ser Lys Phe 
                405                 410                 415     


Val Ala Phe Asp Arg Ile Ile Asn Pro Thr Lys Asp Leu Tyr Glu Asp 
            420                 425                 430         


Lys Asn Ile Arg Ile Pro Glu Arg Phe Gln Lys Val Ser Glu Gln Thr 
        435                 440                 445             


Gln Gln Cys Asp Gly Met Arg Ile Cys Glu Gln Ala Pro Gln Gln Ala 
    450                 455                 460                 


Leu Pro Gln Ser Phe Pro Lys Pro Gly Thr Gln Gly His Thr Lys Asn 
465                 470                 475                 480 


Leu Leu Arg Pro Thr Lys Leu Asn Leu Gln Lys Ser Asn Arg Asn Ser 
                485                 490                 495     


Leu Leu Ala Leu Gly Ser Asn Lys Asn Pro Arg Asn Lys Asp Ile Leu 
            500                 505                 510         


Asp Lys Ile Lys Ser Lys Ala Lys Glu Thr Lys Arg Asn Asp Asp Lys 
        515                 520                 525             


Gly Asp His Thr Tyr Arg Leu Ile Ser Val Val Ser His Leu Gly Lys 
    530                 535                 540                 


Thr Leu Lys Ser Gly His Tyr Ile Cys Asp Ala Tyr Asp Phe Glu Lys 
545                 550                 555                 560 


Gln Ile Trp Phe Thr Tyr Asp Asp Met Arg Val Leu Gly Ile Gln Glu 
                565                 570                 575     


Ala Gln Met Gln Glu Asp Arg Arg Cys Thr Gly Tyr Ile Phe Phe Tyr 
            580                 585                 590         


Met His Asn 
        595 


<210> 139
<211> 723
<212> PRT
<213> Homo sapiens

<400> 139
Leu Pro Gly Phe Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Val Ile Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe 
            20                  25                  30          


Phe His Asp Arg Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu 
        35                  40                  45              


Gly Thr Gly Gly Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala 
    50                  55                  60                  


Leu Trp Lys Gly Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala 
65                  70                  75                  80  


Ile Val Ala Ser Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp 
                85                  90                  95      


Ala Gln Glu Phe Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu 
            100                 105                 110         


Asn Arg Ile Gln Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly 
        115                 120                 125             


Arg Pro Asp Glu Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met 
    130                 135                 140                 


Arg Asn Asp Ser Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser 
145                 150                 155                 160 


Lys Leu Val Cys Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro 
                165                 170                 175     


Phe Leu Tyr Leu Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro 
            180                 185                 190         


Val Phe Tyr Phe Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu 
        195                 200                 205             


Val Ser Val Ser Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser 
    210                 215                 220                 


Leu Ser Gln Ser Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu 
225                 230                 235                 240 


Val Ile Lys Asn Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu 
                245                 250                 255     


Asp Thr Val Ser Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser 
            260                 265                 270         


Ser Glu Leu Ala Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg 
        275                 280                 285             


Pro Gln Val Pro Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg 
    290                 295                 300                 


Lys Gln Gln Ser Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr 
305                 310                 315                 320 


Arg Val Gly Tyr Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp 
                325                 330                 335     


His Lys Gly Leu Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ala Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu 
        355                 360                 365             


Glu Gly Tyr Ala Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln 
    370                 375                 380                 


Pro Gly Arg Met Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu 
385                 390                 395                 400 


Leu Ser Thr Gly Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile 
                405                 410                 415     


Gln Pro Pro Glu Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr 
            420                 425                 430         


Gly Leu Pro Arg Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser 
        435                 440                 445             


Thr Ser Gly Ile Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val 
    450                 455                 460                 


Gly Ser Leu Pro Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val 
465                 470                 475                 480 


Pro Gly Tyr Gln His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln 
                485                 490                 495     


Phe Phe Ile Tyr Lys Ile Asp Ser Ser Asn Arg Glu Gln Arg Leu Glu 
            500                 505                 510         


Asp Lys Gly Asp Thr Pro Leu Glu Leu Gly Asp Asp Cys Ser Leu Ala 
        515                 520                 525             


Leu Val Trp Arg Asn Asn Glu Arg Leu Gln Glu Phe Val Leu Val Ala 
    530                 535                 540                 


Ser Lys Glu Leu Glu Cys Ala Glu Asp Pro Gly Ser Ala Gly Glu Ala 
545                 550                 555                 560 


Ala Arg Ala Gly His Phe Thr Leu Asp Gln Cys Leu Asn Leu Phe Thr 
                565                 570                 575     


Arg Pro Glu Val Leu Ala Pro Glu Glu Ala Trp Tyr Cys Pro Gln Cys 
            580                 585                 590         


Lys Gln His Arg Glu Ala Ser Lys Gln Leu Leu Leu Trp Arg Leu Pro 
        595                 600                 605             


Asn Val Leu Ile Val Gln Leu Lys Arg Phe Ser Phe Arg Ser Phe Ile 
    610                 615                 620                 


Trp Arg Asp Lys Ile Asn Asp Leu Val Glu Phe Pro Val Arg Asn Leu 
625                 630                 635                 640 


Asp Leu Ser Lys Phe Cys Ile Gly Gln Lys Glu Glu Gln Leu Pro Ser 
                645                 650                 655     


Tyr Asp Leu Tyr Ala Val Ile Asn His Tyr Gly Gly Met Ile Gly Gly 
            660                 665                 670         


His Tyr Thr Ala Cys Ala Arg Leu Pro Asn Asp Arg Ser Ser Gln Arg 
        675                 680                 685             


Ser Asp Val Gly Trp Arg Leu Phe Asp Asp Ser Thr Val Thr Thr Val 
    690                 695                 700                 


Asp Glu Ser Gln Val Val Thr Arg Tyr Ala Tyr Val Leu Phe Tyr Arg 
705                 710                 715                 720 


Arg Arg Asn 
            


<210> 140
<211> 386
<212> PRT
<213> Homo sapiens

<400> 140
Ser Leu Gln Pro Arg Gly Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile 
1               5                   10                  15      


Asn Ala Thr Leu Gln Ala Leu Val Ala Cys Pro Pro Met Tyr His Leu 
            20                  25                  30          


Met Lys Phe Ile Pro Leu Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser 
        35                  40                  45              


Thr Pro Met Ile Asp Ser Phe Val Arg Leu Met Asn Glu Phe Thr Asn 
    50                  55                  60                  


Met Pro Val Pro Pro Lys Pro Arg Gln Ala Leu Gly Asp Lys Ile Val 
65                  70                  75                  80  


Arg Asp Ile Arg Pro Gly Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg 
                85                  90                  95      


Leu Leu Thr Val Asn Lys Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu 
            100                 105                 110         


Asp Ala Glu Glu Tyr Leu Gly Phe Ile Leu Asn Gly Leu His Glu Glu 
        115                 120                 125             


Met Leu Asn Leu Lys Lys Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr 
    130                 135                 140                 


Ile Ser Asn Gly Pro Lys Asn His Ser Val Asn Glu Glu Glu Gln Glu 
145                 150                 155                 160 


Glu Gln Gly Glu Gly Ser Glu Asp Glu Trp Glu Gln Val Gly Pro Arg 
                165                 170                 175     


Asn Lys Thr Ser Val Thr Arg Gln Ala Asp Phe Val Gln Thr Pro Ile 
            180                 185                 190         


Thr Gly Ile Phe Gly Gly His Ile Arg Ser Val Val Tyr Gln Gln Ser 
        195                 200                 205             


Ser Lys Glu Ser Ala Thr Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp 
    210                 215                 220                 


Ile Gln Ser Asp Lys Ile Arg Thr Val Gln Asp Ala Leu Glu Ser Leu 
225                 230                 235                 240 


Val Ala Arg Glu Ser Val Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu 
                245                 250                 255     


Val Glu Ile Ser Arg Arg Val Thr Leu Glu Lys Leu Pro Pro Val Leu 
            260                 265                 270         


Val Leu His Leu Lys Arg Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln 
        275                 280                 285             


Lys Leu Ile Lys Asn Ile Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys 
    290                 295                 300                 


Glu Leu Leu Ser Pro Gly Val Lys Asn Lys Asn Phe Lys Cys His Arg 
305                 310                 315                 320 


Thr Tyr Arg Leu Phe Ala Val Val Tyr His His Gly Asn Ser Ala Thr 
                325                 330                 335     


Gly Gly His Tyr Thr Thr Asp Val Phe Gln Ile Gly Leu Asn Gly Trp 
            340                 345                 350         


Leu Arg Ile Asp Asp Gln Thr Val Lys Val Ile Asn Gln Tyr Gln Val 
        355                 360                 365             


Val Lys Pro Thr Ala Glu Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg 
    370                 375                 380                 


Val Asp 
385     


<210> 141
<211> 658
<212> PRT
<213> Homo sapiens

<400> 141
Met Asp Arg Cys Lys His Val Gly Arg Leu Arg Leu Ala Gln Asp His 
1               5                   10                  15      


Ser Ile Leu Asn Pro Gln Lys Trp Cys Cys Leu Glu Cys Ala Thr Thr 
            20                  25                  30          


Glu Ser Val Trp Ala Cys Leu Lys Cys Ser His Val Ala Cys Gly Arg 
        35                  40                  45              


Tyr Ile Glu Asp His Ala Leu Lys His Phe Glu Glu Thr Gly His Pro 
    50                  55                  60                  


Leu Ala Met Glu Val Arg Asp Leu Tyr Val Phe Cys Tyr Leu Cys Lys 
65                  70                  75                  80  


Asp Tyr Val Leu Asn Asp Asn Pro Glu Gly Asp Leu Lys Leu Leu Arg 
                85                  90                  95      


Ser Ser Leu Leu Ala Val Arg Gly Gln Lys Gln Asp Thr Pro Val Arg 
            100                 105                 110         


Arg Gly Arg Thr Leu Arg Ser Met Ala Ser Gly Glu Asp Val Val Leu 
        115                 120                 125             


Pro Gln Arg Ala Pro Gln Gly Gln Pro Gln Met Leu Thr Ala Leu Trp 
    130                 135                 140                 


Tyr Arg Arg Gln Arg Leu Leu Ala Arg Thr Leu Arg Leu Trp Phe Glu 
145                 150                 155                 160 


Lys Ser Ser Arg Gly Gln Ala Lys Leu Glu Gln Arg Arg Gln Glu Glu 
                165                 170                 175     


Ala Leu Glu Arg Lys Lys Glu Glu Ala Arg Arg Arg Arg Arg Glu Val 
            180                 185                 190         


Lys Arg Arg Leu Leu Glu Glu Leu Ala Ser Thr Pro Pro Arg Lys Ser 
        195                 200                 205             


Ala Arg Leu Leu Leu His Thr Pro Arg Asp Ala Gly Pro Ala Ala Ser 
    210                 215                 220                 


Arg Pro Ala Ala Leu Pro Thr Ser Arg Arg Val Pro Ala Ala Thr Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Gln Pro Ala Met Ala Pro Gly Val Thr Gly Leu Arg 
                245                 250                 255     


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Ile Leu Gln Val Leu Ser 
            260                 265                 270         


His Leu Gln Lys Phe Arg Glu Cys Phe Leu Asn Leu Asp Pro Ser Lys 
        275                 280                 285             


Thr Glu His Leu Phe Pro Lys Ala Thr Asn Gly Lys Thr Gln Leu Ser 
    290                 295                 300                 


Gly Lys Pro Thr Asn Ser Ser Ala Thr Glu Leu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Arg Ala Glu Ala Cys Glu Arg Glu Gly Phe Cys Trp Asn Gly Arg Ala 
                325                 330                 335     


Ser Ile Ser Arg Ser Leu Glu Leu Ile Gln Asn Lys Glu Pro Ser Ser 
            340                 345                 350         


Lys His Ile Ser Leu Cys Arg Glu Leu His Thr Leu Phe Arg Val Met 
        355                 360                 365             


Trp Ser Gly Lys Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser 
    370                 375                 380                 


Val Trp Ser Leu Ile Pro Ala Phe Arg Gly Tyr Asp Gln Gln Asp Ala 
385                 390                 395                 400 


Gln Glu Phe Leu Cys Glu Leu Leu His Lys Val Gln Gln Glu Leu Glu 
                405                 410                 415     


Ser Glu Gly Thr Thr Arg Arg Ile Leu Ile Pro Phe Ser Gln Arg Lys 
            420                 425                 430         


Leu Thr Lys Gln Val Leu Lys Val Val Asn Thr Ile Phe His Gly Gln 
        435                 440                 445             


Leu Leu Ser Gln Val Thr Cys Ile Ser Cys Asn Tyr Lys Ser Asn Thr 
    450                 455                 460                 


Ile Glu Pro Phe Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr His 
465                 470                 475                 480 


Cys Ile Glu Lys Gly Phe Val Pro Leu Asn Gln Thr Glu Cys Leu Leu 
                485                 490                 495     


Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu Ala Leu Glu Gly Arg 
            500                 505                 510         


Ile Tyr Ala Cys Asp Gln Cys Asn Ser Lys Arg Arg Lys Ser Asn Pro 
        515                 520                 525             


Lys Pro Leu Val Leu Ser Glu Ala Arg Lys Gln Leu Met Ile Tyr Arg 
    530                 535                 540                 


Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg Phe Arg Trp Ser Gly 
545                 550                 555                 560 


Arg Asn His Arg Glu Lys Ile Gly Val His Val Val Phe Asp Gln Val 
                565                 570                 575     


Leu Thr Met Glu Pro Tyr Cys Cys Arg Asp Met Leu Ser Ser Leu Asp 
            580                 585                 590         


Lys Glu Thr Phe Ala Tyr Asp Leu Ser Ala Val Val Met His His Gly 
        595                 600                 605             


Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr Cys Tyr Asn Thr Glu 
    610                 615                 620                 


Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys Leu Asn Val Cys Ser 
625                 630                 635                 640 


Val Glu Glu Val Cys Lys Thr Gln Ala Tyr Ile Leu Phe Tyr Thr Gln 
                645                 650                 655     


Arg Thr 
        


<210> 142
<211> 300
<212> PRT
<213> Homo sapiens

<400> 142
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Leu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


Pro Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Cys 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly Tyr Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 143
<211> 311
<212> PRT
<213> Homo sapiens

<400> 143
Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys Ala Val 
            20                  25                  30          


Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val Pro Leu 
        35                  40                  45              


Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys Pro Val 
    50                  55                  60                  


Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu Asp Ser 
65                  70                  75                  80  


Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu Asp Asn 
                85                  90                  95      


Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile Pro Lys 
            100                 105                 110         


Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu Val Asp 
        115                 120                 125             


Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu Ser Ile 
    130                 135                 140                 


Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val Ala Val 
145                 150                 155                 160 


Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His Gly Leu 
                165                 170                 175     


Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro Val Leu 
            180                 185                 190         


His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp Gln Asn 
        195                 200                 205             


Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro Leu Asp 
    210                 215                 220                 


Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr Ile Leu 
225                 230                 235                 240 


His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His Tyr Val 
                245                 250                 255     


Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe Asp Asp 
            260                 265                 270         


Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His Asn Tyr 
        275                 280                 285             


Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn Ala Tyr 
    290                 295                 300                 


Met Leu Val Tyr Ile Arg Glu 
305                 310     


<210> 144
<211> 338
<212> PRT
<213> Homo sapiens

<400> 144
Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp Tyr 
            20                  25                  30          


Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn Ala 
        35                  40                  45              


His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile Trp 
    50                  55                  60                  


Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr Gln 
65                  70                  75                  80  


Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val Asn 
            100                 105                 110         


Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His Leu 
        115                 120                 125             


Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu Arg 
    130                 135                 140                 


Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser Ser 
145                 150                 155                 160 


Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro Phe 
                165                 170                 175     


Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val Thr 
            180                 185                 190         


Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp Gly 
        195                 200                 205             


Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys Ile 
    210                 215                 220                 


Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His Leu 
225                 230                 235                 240 


Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr Phe 
                245                 250                 255     


Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser Glu 
            260                 265                 270         


Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His Ser 
        275                 280                 285             


Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro Gly 
    290                 295                 300                 


Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met Ser 
305                 310                 315                 320 


Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu Leu 
                325                 330                 335     


Ala Ser 
        


<210> 145
<211> 363
<212> PRT
<213> Homo sapiens

<400> 145
Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser Ser Val Leu Asp 
            20                  25                  30          


Thr Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser 
        35                  40                  45              


Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile Val Asn Pro Leu Arg Ile 
    50                  55                  60                  


Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met Lys Leu Arg Lys Ile Leu 
65                  70                  75                  80  


Glu Lys Val Glu Ala Ala Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro 
                85                  90                  95      


Glu Glu Phe Leu Asn Ile Leu Phe His His Ile Leu Arg Val Glu Pro 
            100                 105                 110         


Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe 
        115                 120                 125             


Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Thr Ile 
    130                 135                 140                 


Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala 
145                 150                 155                 160 


Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys Asp 
                165                 170                 175     


Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr 
            180                 185                 190         


Asp Leu Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu 
        195                 200                 205             


Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala 
    210                 215                 220                 


Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr Gln Val His Leu 
225                 230                 235                 240 


His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser Leu Pro Lys 
                245                 250                 255     


Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln Asn 
            260                 265                 270         


Met Glu Leu Phe Ala Val Leu Cys Ile Glu Thr Ser His Tyr Val Ala 
        275                 280                 285             


Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser 
    290                 295                 300                 


Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln Val 
305                 310                 315                 320 


Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp 
                325                 330                 335     


Leu His Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu 
            340                 345                 350         


Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln Ser 
        355                 360             


<210> 146
<211> 300
<212> PRT
<213> Homo sapiens

<400> 146
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 147
<211> 341
<212> PRT
<213> Homo sapiens

<400> 147
Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His 
1               5                   10                  15      


Thr Pro Leu Leu Arg Asp Phe Phe Leu Ser Asp Arg His Arg Cys Glu 
            20                  25                  30          


Met Gln Ser Pro Ser Ser Cys Leu Val Cys Glu Met Ser Ser Leu Phe 
        35                  40                  45              


Gln Glu Phe Tyr Ser Gly His Arg Ser Pro His Ile Pro Tyr Lys Leu 
    50                  55                  60                  


Leu His Leu Val Trp Thr His Ala Arg His Leu Ala Gly Tyr Glu Gln 
65                  70                  75                  80  


Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp Val Leu His Arg 
                85                  90                  95      


His Cys Lys Gly Asp Asp Asn Gly Lys Lys Ala Asn Asn Pro Asn His 
            100                 105                 110         


Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp 
        115                 120                 125             


Val Thr Cys Gln Val Cys His Gly Val Ser Thr Thr Ile Asp Pro Phe 
    130                 135                 140                 


Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Ser Thr Pro Phe Trp Pro 
145                 150                 155                 160 


Leu Ser Pro Gly Ser Glu Gly Asn Val Val Asn Gly Glu Ser His Val 
                165                 170                 175     


Ser Gly Thr Thr Thr Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg Pro 
            180                 185                 190         


Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Ser Gly Cys His Ser 
        195                 200                 205             


Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro Ile Val 
    210                 215                 220                 


Ala Cys Phe His Leu Lys Arg Phe Glu His Ser Ala Lys Leu Arg Arg 
225                 230                 235                 240 


Lys Ile Thr Thr Tyr Val Ser Phe Pro Leu Glu Leu Asp Met Thr Pro 
                245                 250                 255     


Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly Gln Tyr Gln Gln 
            260                 265                 270         


Pro Thr Asp Ser Leu Asn Asn Asp Asn Lys Tyr Ser Leu Phe Ala Val 
        275                 280                 285             


Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile 
    290                 295                 300                 


Arg Gln His Lys Asp Gln Trp Phe Lys Cys Asp Asp Ala Ile Ile Thr 
305                 310                 315                 320 


Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu Phe 
                325                 330                 335     


Tyr His Lys Gln Phe 
            340     


<210> 148
<211> 440
<212> PRT
<213> Homo sapiens

<400> 148
Lys Gly Leu Val Pro Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Leu Leu Gln Gly Leu Ser Ala Cys Pro Ala Phe Ile Arg Trp 
            20                  25                  30          


Leu Glu Glu Phe Thr Ser Gln Tyr Ser Arg Asp Gln Lys Glu Pro Pro 
        35                  40                  45              


Ser His Gln Tyr Leu Ser Leu Thr Leu Leu His Leu Leu Lys Ala Leu 
    50                  55                  60                  


Ser Cys Gln Glu Val Thr Asp Asp Glu Val Leu Asp Ala Ser Cys Leu 
65                  70                  75                  80  


Leu Asp Val Leu Arg Met Tyr Arg Trp Gln Ile Ser Ser Phe Glu Glu 
                85                  90                  95      


Gln Asp Ala His Glu Leu Phe His Val Ile Thr Ser Ser Leu Glu Asp 
            100                 105                 110         


Glu Arg Asp Arg Gln Pro Arg Val Thr His Leu Phe Asp Val His Ser 
        115                 120                 125             


Leu Glu Gln Gln Ser Glu Ile Thr Pro Lys Gln Ile Thr Cys Arg Thr 
    130                 135                 140                 


Arg Gly Ser Pro His Pro Thr Ser Asn His Trp Lys Ser Gln His Pro 
145                 150                 155                 160 


Phe His Gly Arg Leu Thr Ser Asn Met Val Cys Lys His Cys Glu His 
                165                 170                 175     


Gln Ser Pro Val Arg Phe Asp Thr Phe Asp Ser Leu Ser Leu Ser Ile 
            180                 185                 190         


Pro Ala Ala Thr Trp Gly His Pro Leu Thr Leu Asp His Cys Leu His 
        195                 200                 205             


His Phe Ile Ser Ser Glu Ser Val Arg Asp Val Val Cys Asp Asn Cys 
    210                 215                 220                 


Thr Lys Ile Glu Ala Lys Gly Thr Leu Asn Gly Glu Lys Val Glu His 
225                 230                 235                 240 


Gln Arg Thr Thr Phe Val Lys Gln Leu Lys Leu Gly Lys Leu Pro Gln 
                245                 250                 255     


Cys Leu Cys Ile His Leu Gln Arg Leu Ser Trp Ser Ser His Gly Thr 
            260                 265                 270         


Pro Leu Lys Arg His Glu His Val Gln Phe Asn Glu Phe Leu Met Met 
        275                 280                 285             


Asp Ile Tyr Lys Tyr His Leu Leu Gly His Lys Pro Ser Gln His Asn 
    290                 295                 300                 


Pro Lys Leu Asn Lys Asn Pro Gly Pro Thr Leu Glu Leu Gln Asp Gly 
305                 310                 315                 320 


Pro Gly Ala Pro Thr Pro Val Leu Asn Gln Pro Gly Ala Pro Lys Thr 
                325                 330                 335     


Gln Ile Phe Met Asn Gly Ala Cys Ser Pro Ser Leu Leu Pro Thr Leu 
            340                 345                 350         


Ser Ala Pro Met Pro Phe Pro Leu Pro Val Val Pro Asp Tyr Ser Ser 
        355                 360                 365             


Ser Thr Tyr Leu Phe Arg Leu Met Ala Val Val Val His His Gly Asp 
    370                 375                 380                 


Met His Ser Gly His Phe Val Thr Tyr Arg Arg Ser Pro Pro Ser Ala 
385                 390                 395                 400 


Arg Asn Pro Leu Ser Thr Ser Asn Gln Trp Leu Trp Val Ser Asp Asp 
                405                 410                 415     


Thr Val Arg Lys Ala Ser Leu Gln Glu Val Leu Ser Ser Ser Ala Tyr 
            420                 425                 430         


Leu Leu Phe Tyr Glu Arg Val Leu 
        435                 440 


<210> 149
<211> 496
<212> PRT
<213> Homo sapiens

<400> 149
Gly Trp Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser 
1               5                   10                  15      


Ala Val Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val 
            20                  25                  30          


Leu Ser Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His 
        35                  40                  45              


Thr Glu Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe 
    50                  55                  60                  


Ala Leu Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala 
65                  70                  75                  80  


Leu Asp Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln 
                85                  90                  95      


Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala 
            100                 105                 110         


Phe Gln Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn 
        115                 120                 125             


Pro Met Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg 
    130                 135                 140                 


Glu Gly Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu 
145                 150                 155                 160 


Gln Val Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met 
                165                 170                 175     


Val Glu Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr 
            180                 185                 190         


Gly Gln Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu 
        195                 200                 205             


Leu Ser Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile 
    210                 215                 220                 


His Asn Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met 
225                 230                 235                 240 


Tyr Arg Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys 
                245                 250                 255     


Leu Lys Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val 
            260                 265                 270         


Lys Tyr Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys 
        275                 280                 285             


Tyr Val Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro 
    290                 295                 300                 


Pro Glu Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys 
305                 310                 315                 320 


Ser Val Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser 
                325                 330                 335     


Ser Gln Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro 
            340                 345                 350         


Lys Ser Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser 
        355                 360                 365             


Gln Pro Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys 
    370                 375                 380                 


Thr Cys Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp 
385                 390                 395                 400 


Leu Lys Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr 
                405                 410                 415     


Cys Asp Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu 
            420                 425                 430         


Val His Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr 
        435                 440                 445             


Asn Gln Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr 
    450                 455                 460                 


Glu Ser Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg 
465                 470                 475                 480 


Asn Val Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr 
                485                 490                 495     


<210> 150
<211> 300
<212> PRT
<213> Homo sapiens

<400> 150
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Lys Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 151
<211> 644
<212> PRT
<213> Homo sapiens

<400> 151
Pro Val Pro Gly Val Ala Gly Leu Arg Asn His Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Thr Leu Gln Cys Leu Ser Asn Thr Glu Leu Phe Ala Glu 
            20                  25                  30          


Tyr Leu Ala Leu Gly Gln Tyr Arg Ala Gly Arg Pro Glu Pro Ser Pro 
        35                  40                  45              


Asp Pro Glu Gln Pro Ala Gly Arg Gly Ala Gln Gly Gln Gly Glu Val 
    50                  55                  60                  


Thr Glu Gln Leu Ala His Leu Val Arg Ala Leu Trp Thr Leu Glu Tyr 
65                  70                  75                  80  


Thr Pro Gln His Ser Arg Asp Phe Lys Thr Ile Val Ser Lys Asn Ala 
                85                  90                  95      


Leu Gln Tyr Arg Gly Asn Ser Gln His Asp Ala Gln Glu Phe Leu Leu 
            100                 105                 110         


Trp Leu Leu Asp Arg Val His Glu Asp Leu Asn His Ser Val Lys Gln 
        115                 120                 125             


Ser Gly Gln Pro Pro Leu Lys Pro Pro Ser Glu Thr Asp Met Met Pro 
    130                 135                 140                 


Glu Gly Pro Ser Phe Pro Val Cys Ser Thr Phe Val Gln Glu Leu Phe 
145                 150                 155                 160 


Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys Gln Lys Gln 
                165                 170                 175     


Ser Asn Thr Phe Asp Pro Phe Leu Cys Ile Ser Leu Pro Ile Pro Leu 
            180                 185                 190         


Pro His Thr Arg Pro Leu Tyr Val Thr Val Val Tyr Gln Gly Lys Cys 
        195                 200                 205             


Ser His Cys Met Arg Ile Gly Val Ala Val Pro Leu Ser Gly Thr Val 
    210                 215                 220                 


Ala Arg Leu Arg Glu Ala Val Ser Met Glu Thr Lys Ile Pro Thr Asp 
225                 230                 235                 240 


Gln Ile Val Leu Thr Glu Met Tyr Tyr Asp Gly Phe His Arg Ser Phe 
                245                 250                 255     


Cys Asp Thr Asp Asp Leu Glu Thr Val His Glu Ser Asp Cys Ile Phe 
            260                 265                 270         


Ala Phe Glu Thr Pro Glu Ile Phe Arg Pro Glu Gly Ile Leu Ser Gln 
        275                 280                 285             


Arg Gly Ile His Leu Asn Asn Asn Leu Asn His Leu Lys Phe Gly Leu 
    290                 295                 300                 


Asp Tyr His Arg Leu Ser Ser Pro Thr Gln Thr Ala Ala Lys Gln Gly 
305                 310                 315                 320 


Lys Met Asp Ser Pro Thr Ser Arg Ala Gly Ser Asp Lys Ile Val Leu 
                325                 330                 335     


Leu Val Cys Asn Arg Ala Cys Thr Gly Gln Gln Gly Lys Arg Phe Gly 
            340                 345                 350         


Leu Pro Phe Val Leu His Leu Glu Lys Thr Ile Ala Trp Asp Leu Leu 
        355                 360                 365             


Gln Lys Glu Ile Leu Glu Lys Met Lys Tyr Phe Leu Arg Pro Thr Val 
    370                 375                 380                 


Cys Ile Gln Val Cys Pro Phe Ser Leu Arg Val Val Ser Val Val Gly 
385                 390                 395                 400 


Ile Thr Tyr Leu Leu Pro Gln Glu Glu Gln Pro Leu Cys His Pro Ile 
                405                 410                 415     


Val Glu Arg Ala Leu Lys Ser Cys Gly Pro Gly Gly Thr Ala His Val 
            420                 425                 430         


Lys Leu Val Val Glu Trp Asp Lys Glu Thr Arg Asp Phe Leu Phe Val 
        435                 440                 445             


Asn Thr Glu Asp Glu Tyr Ile Pro Asp Ala Glu Ser Val Arg Leu Gln 
    450                 455                 460                 


Arg Glu Arg His His Gln Pro Gln Thr Cys Thr Leu Ser Gln Cys Phe 
465                 470                 475                 480 


Gln Leu Tyr Thr Lys Glu Glu Arg Leu Ala Pro Asp Asp Ala Trp Arg 
                485                 490                 495     


Cys Pro His Cys Lys Gln Leu Gln Gln Gly Ser Ile Thr Leu Ser Leu 
            500                 505                 510         


Trp Thr Leu Pro Asp Val Leu Ile Ile His Leu Lys Arg Phe Arg Gln 
        515                 520                 525             


Glu Gly Asp Arg Arg Met Lys Leu Gln Asn Met Val Lys Phe Pro Leu 
    530                 535                 540                 


Thr Gly Leu Asp Met Thr Pro His Val Val Lys Arg Ser Gln Ser Ser 
545                 550                 555                 560 


Trp Ser Leu Pro Ser His Trp Ser Pro Trp Arg Arg Pro Tyr Gly Leu 
                565                 570                 575     


Gly Arg Asp Pro Glu Asp Tyr Ile Tyr Asp Leu Tyr Ala Val Cys Asn 
            580                 585                 590         


His His Gly Thr Met Gln Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn 
        595                 600                 605             


Ser Val Asp Gly Leu Trp Tyr Cys Phe Asp Asp Ser Asp Val Gln Gln 
    610                 615                 620                 


Leu Ser Glu Asp Glu Val Cys Thr Gln Thr Ala Tyr Ile Leu Phe Tyr 
625                 630                 635                 640 


Gln Arg Arg Thr 
                


<210> 152
<211> 344
<212> PRT
<213> Homo sapiens

<400> 152
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 153
<211> 300
<212> PRT
<213> Homo sapiens

<400> 153
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Asp Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Lys Leu Tyr Met Ser Gln Thr Asn Ser Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 154
<211> 382
<212> PRT
<213> Homo sapiens

<400> 154
Glu Thr Gly Tyr Val Gly Leu Val Asn Gln Ala Met Thr Cys Tyr Leu 
1               5                   10                  15      


Asn Ser Leu Leu Gln Thr Leu Phe Met Thr Pro Glu Phe Arg Asn Ala 
            20                  25                  30          


Leu Tyr Lys Trp Glu Phe Glu Glu Ser Glu Glu Asp Pro Val Thr Ser 
        35                  40                  45              


Ile Pro Tyr Gln Leu Gln Arg Leu Phe Val Leu Leu Gln Thr Ser Lys 
    50                  55                  60                  


Lys Arg Ala Ile Glu Thr Thr Asp Val Thr Arg Ser Phe Gly Trp Asp 
65                  70                  75                  80  


Ser Ser Glu Ala Trp Gln Gln His Asp Val Gln Glu Leu Cys Arg Val 
                85                  90                  95      


Met Phe Asp Ala Leu Glu Gln Lys Trp Lys Gln Thr Glu Gln Ala Asp 
            100                 105                 110         


Leu Ile Asn Glu Leu Tyr Gln Gly Lys Leu Lys Asp Tyr Val Arg Cys 
        115                 120                 125             


Leu Glu Cys Gly Tyr Glu Gly Trp Arg Ile Asp Thr Tyr Leu Asp Ile 
    130                 135                 140                 


Pro Leu Val Ile Arg Pro Tyr Gly Ser Ser Gln Ala Phe Ala Ser Val 
145                 150                 155                 160 


Glu Glu Ala Leu His Ala Phe Ile Gln Pro Glu Ile Leu Asp Gly Pro 
                165                 170                 175     


Asn Gln Tyr Phe Cys Glu Arg Cys Lys Lys Lys Cys Asp Ala Arg Lys 
            180                 185                 190         


Gly Leu Arg Phe Leu His Phe Pro Tyr Leu Leu Thr Leu Gln Leu Lys 
        195                 200                 205             


Arg Phe Asp Phe Asp Tyr Thr Thr Met His Arg Ile Lys Leu Asn Asp 
    210                 215                 220                 


Arg Met Thr Phe Pro Glu Glu Leu Asp Met Ser Thr Phe Ile Asp Val 
225                 230                 235                 240 


Glu Asp Glu Lys Ser Pro Gln Thr Glu Ser Cys Thr Asp Ser Gly Ala 
                245                 250                 255     


Glu Asn Glu Gly Ser Cys His Ser Asp Gln Met Ser Asn Asp Phe Ser 
            260                 265                 270         


Asn Asp Asp Gly Val Asp Glu Gly Ile Cys Leu Glu Thr Asn Ser Gly 
        275                 280                 285             


Thr Glu Lys Ile Ser Lys Ser Gly Leu Glu Lys Asn Ser Leu Ile Tyr 
    290                 295                 300                 


Glu Leu Phe Ser Val Met Val His Ser Gly Ser Ala Ala Gly Gly His 
305                 310                 315                 320 


Tyr Tyr Ala Cys Ile Lys Ser Phe Ser Asp Glu Gln Trp Tyr Ser Phe 
                325                 330                 335     


Asn Asp Gln His Val Ser Arg Ile Thr Gln Glu Asp Ile Lys Lys Thr 
            340                 345                 350         


His Gly Gly Ser Ser Gly Ser Arg Gly Tyr Tyr Ser Ser Ala Phe Ala 
        355                 360                 365             


Ser Ser Thr Asn Ala Tyr Met Leu Ile Tyr Arg Leu Lys Asp 
    370                 375                 380         


<210> 155
<211> 350
<212> PRT
<213> Homo sapiens

<400> 155
Tyr Thr Val Gly Leu Arg Gly Leu Ile Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Cys Ile Val Gln Ala Leu Thr His Ile Pro Leu Leu Lys Asp 
            20                  25                  30          


Phe Phe Leu Ser Asp Lys His Lys Cys Ile Met Thr Ser Pro Ser Leu 
        35                  40                  45              


Cys Leu Val Cys Glu Met Ser Ser Leu Phe His Ala Met Tyr Ser Gly 
    50                  55                  60                  


Ser Arg Thr Pro His Ile Pro Tyr Lys Leu Leu His Leu Ile Trp Ile 
65                  70                  75                  80  


His Ala Glu His Leu Ala Gly Tyr Arg Gln Gln Asp Ala His Glu Phe 
                85                  90                  95      


Leu Ile Ala Ile Leu Asp Val Leu His Arg His Ser Lys Asp Asp Ser 
            100                 105                 110         


Gly Gly Gln Glu Ala Asn Asn Pro Asn Cys Cys Asn Cys Ile Ile Asp 
        115                 120                 125             


Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val Thr Cys Gln Ala Cys 
    130                 135                 140                 


His Ser Val Ser Thr Thr Ile Asp Pro Cys Trp Asp Ile Ser Leu Asp 
145                 150                 155                 160 


Leu Pro Gly Ser Cys Ala Thr Phe Asp Ser Gln Asn Pro Glu Arg Ala 
                165                 170                 175     


Asp Ser Thr Val Ser Arg Asp Asp His Ile Pro Gly Ile Pro Ser Leu 
            180                 185                 190         


Thr Asp Cys Leu Gln Trp Phe Thr Arg Pro Glu His Leu Gly Ser Ser 
        195                 200                 205             


Ala Lys Ile Lys Cys Asn Ser Cys Gln Ser Tyr Gln Glu Ser Thr Lys 
    210                 215                 220                 


Gln Leu Thr Met Lys Lys Leu Pro Ile Val Ala Cys Phe His Leu Lys 
225                 230                 235                 240 


Arg Phe Glu His Val Gly Lys Gln Arg Arg Lys Ile Asn Thr Phe Ile 
                245                 250                 255     


Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe Leu Ala Ser Thr Lys 
            260                 265                 270         


Glu Ser Arg Met Lys Glu Gly Gln Pro Pro Thr Asp Cys Val Pro Asn 
        275                 280                 285             


Glu Asn Lys Tyr Ser Leu Phe Ala Val Ile Asn His His Gly Thr Leu 
    290                 295                 300                 


Glu Ser Gly His Tyr Thr Ser Phe Ile Arg Gln Gln Lys Asp Gln Trp 
305                 310                 315                 320 


Phe Ser Cys Asp Asp Ala Ile Ile Thr Lys Ala Thr Ile Glu Asp Leu 
                325                 330                 335     


Leu Tyr Ser Glu Gly Tyr Leu Leu Phe Tyr His Lys Gln Gly 
            340                 345                 350 


<210> 156
<211> 306
<212> PRT
<213> Homo sapiens

<400> 156
Arg Val Gly Ala Gly Leu His Asn Leu Gly Asn Thr Cys Phe Leu Asn 
1               5                   10                  15      


Ala Thr Ile Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Leu 
            20                  25                  30          


Leu Ser Lys Glu His Ala Arg Ser Cys His Gln Gly Ser Phe Cys Met 
        35                  40                  45              


Leu Cys Val Met Gln Asn His Ile Val Gln Ala Phe Ala Asn Ser Gly 
    50                  55                  60                  


Asn Ala Ile Lys Pro Val Ser Phe Ile Arg Asp Leu Lys Lys Ile Ala 
65                  70                  75                  80  


Arg His Phe Arg Phe Gly Asn Gln Glu Asp Ala His Glu Phe Leu Arg 
                85                  90                  95      


Tyr Thr Ile Asp Ala Met Gln Lys Ala Cys Leu Asn Gly Cys Ala Lys 
            100                 105                 110         


Leu Asp Arg Gln Thr Gln Ala Thr Thr Leu Val His Gln Ile Phe Gly 
        115                 120                 125             


Gly Tyr Leu Arg Ser Arg Val Lys Cys Ser Val Cys Lys Ser Val Ser 
    130                 135                 140                 


Asp Thr Tyr Asp Pro Tyr Leu Asp Val Ala Leu Glu Ile Arg Gln Ala 
145                 150                 155                 160 


Ala Asn Ile Val Arg Ala Leu Glu Leu Phe Val Lys Ala Asp Val Leu 
                165                 170                 175     


Ser Gly Glu Asn Ala Tyr Met Cys Ala Lys Cys Lys Lys Lys Val Pro 
            180                 185                 190         


Ala Ser Lys Arg Phe Thr Ile His Arg Thr Ser Asn Val Leu Thr Leu 
        195                 200                 205             


Ser Leu Lys Arg Phe Ala Asn Phe Ser Gly Gly Lys Ile Thr Lys Asp 
    210                 215                 220                 


Val Gly Tyr Pro Glu Phe Leu Asn Ile Arg Pro Tyr Met Ser Gln Asn 
225                 230                 235                 240 


Asn Gly Asp Pro Val Met Tyr Gly Leu Tyr Ala Val Leu Val His Ser 
                245                 250                 255     


Gly Tyr Ser Cys His Ala Gly His Tyr Tyr Cys Tyr Val Lys Ala Ser 
            260                 265                 270         


Asn Gly Gln Trp Tyr Gln Met Asn Asp Ser Leu Val His Ser Ser Asn 
        275                 280                 285             


Val Lys Val Val Leu Asn Gln Gln Ala Tyr Val Leu Phe Tyr Leu Arg 
    290                 295                 300                 


Ile Pro 
305     


<210> 157
<211> 411
<212> PRT
<213> Homo sapiens

<400> 157
Thr Pro Gly Val Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met 
1               5                   10                  15      


Asn Ser Val Leu Gln Val Leu Ser His Leu Leu Ile Phe Arg Gln Cys 
            20                  25                  30          


Phe Leu Lys Leu Asp Leu Asn Gln Trp Leu Ala Met Thr Ala Ser Glu 
        35                  40                  45              


Lys Thr Arg Ser Cys Lys His Pro Pro Val Thr Asp Thr Val Val Tyr 
    50                  55                  60                  


Gln Met Asn Glu Cys Gln Glu Lys Asp Thr Gly Phe Val Cys Ser Arg 
65                  70                  75                  80  


Gln Ser Ser Leu Ser Ser Gly Leu Ser Gly Gly Ala Ser Lys Gly Arg 
                85                  90                  95      


Lys Met Glu Leu Ile Gln Pro Lys Glu Pro Thr Ser Gln Tyr Ile Ser 
            100                 105                 110         


Leu Cys His Glu Leu His Thr Leu Phe Gln Val Met Trp Ser Gly Lys 
        115                 120                 125             


Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser Val Trp Arg Leu 
    130                 135                 140                 


Ile Pro Ala Phe Arg Gly Tyr Ala Gln Gln Asp Ala Gln Glu Phe Leu 
145                 150                 155                 160 


Cys Glu Leu Leu Asp Lys Ile Gln Arg Glu Leu Glu Thr Thr Gly Thr 
                165                 170                 175     


Ser Leu Pro Ala Leu Ile Pro Thr Ser Gln Arg Lys Leu Ile Lys Gln 
            180                 185                 190         


Val Leu Asn Val Val Asn Asn Ile Phe His Gly Gln Leu Leu Ser Gln 
        195                 200                 205             


Val Thr Cys Leu Ala Cys Asp Asn Lys Ser Asn Thr Ile Glu Pro Phe 
    210                 215                 220                 


Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr Gln Cys Ser Gly Lys 
225                 230                 235                 240 


Asp Ile Ala Ser Gln Pro Cys Leu Val Thr Glu Met Leu Ala Lys Phe 
                245                 250                 255     


Thr Glu Thr Glu Ala Leu Glu Gly Lys Ile Tyr Val Cys Asp Gln Cys 
            260                 265                 270         


Asn Ser Lys Arg Arg Arg Phe Ser Ser Lys Pro Val Val Leu Thr Glu 
        275                 280                 285             


Ala Gln Lys Gln Leu Met Ile Cys His Leu Pro Gln Val Leu Arg Leu 
    290                 295                 300                 


His Leu Lys Arg Phe Arg Trp Ser Gly Arg Asn Asn Arg Glu Lys Ile 
305                 310                 315                 320 


Gly Val His Val Gly Phe Glu Glu Ile Leu Asn Met Glu Pro Tyr Cys 
                325                 330                 335     


Cys Arg Glu Thr Leu Lys Ser Leu Arg Pro Glu Cys Phe Ile Tyr Asp 
            340                 345                 350         


Leu Ser Ala Val Val Met His His Gly Lys Gly Phe Gly Ser Gly His 
        355                 360                 365             


Tyr Thr Ala Tyr Cys Tyr Asn Ser Glu Gly Gly Phe Trp Val His Cys 
    370                 375                 380                 


Asn Asp Ser Lys Leu Ser Met Cys Thr Met Asp Glu Val Cys Lys Ala 
385                 390                 395                 400 


Gln Ala Tyr Ile Leu Phe Tyr Thr Gln Arg Val 
                405                 410     


<210> 158
<211> 337
<212> PRT
<213> Homo sapiens

<400> 158
Pro Ala Leu Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Ile Leu Gln Cys Leu Cys Asn Ala Pro His Leu Ala Asp Tyr Phe 
            20                  25                  30          


Asn Arg Asn Cys Tyr Gln Asp Asp Ile Asn Arg Ser Asn Leu Leu Gly 
        35                  40                  45              


His Lys Gly Glu Val Ala Glu Glu Phe Gly Ile Ile Met Lys Ala Leu 
    50                  55                  60                  


Trp Thr Gly Gln Tyr Arg Tyr Ile Ser Pro Lys Asp Phe Lys Ile Thr 
65                  70                  75                  80  


Ile Gly Lys Ile Asn Asp Gln Phe Ala Gly Tyr Ser Gln Gln Asp Ser 
                85                  90                  95      


Gln Glu Leu Leu Leu Phe Leu Met Asp Gly Leu His Glu Asp Leu Asn 
            100                 105                 110         


Lys Ala Asp Asn Arg Lys Arg Tyr Lys Glu Glu Asn Asn Asp His Leu 
        115                 120                 125             


Asp Asp Phe Lys Ala Ala Glu His Ala Trp Gln Lys His Lys Gln Leu 
    130                 135                 140                 


Asn Glu Ser Ile Ile Val Ala Leu Phe Gln Gly Gln Phe Lys Ser Thr 
145                 150                 155                 160 


Val Gln Cys Leu Thr Cys His Lys Lys Ser Arg Thr Phe Glu Ala Phe 
                165                 170                 175     


Met Tyr Leu Ser Leu Pro Leu Ala Ser Thr Ser Lys Cys Thr Leu Gln 
            180                 185                 190         


Asp Cys Leu Arg Leu Phe Ser Lys Glu Glu Lys Leu Thr Asp Asn Asn 
        195                 200                 205             


Arg Phe Tyr Cys Ser His Cys Arg Ala Arg Arg Asp Ser Leu Lys Lys 
    210                 215                 220                 


Ile Glu Ile Trp Lys Leu Pro Pro Val Leu Leu Val His Leu Lys Arg 
225                 230                 235                 240 


Phe Ser Tyr Asp Gly Arg Trp Lys Gln Lys Leu Gln Thr Ser Val Asp 
                245                 250                 255     


Phe Pro Leu Glu Asn Leu Asp Leu Ser Gln Tyr Val Ile Gly Pro Lys 
            260                 265                 270         


Asn Asn Leu Lys Lys Tyr Asn Leu Phe Ser Val Ser Asn His Tyr Gly 
        275                 280                 285             


Gly Leu Asp Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn Ala Ala Arg 
    290                 295                 300                 


Gln Arg Trp Phe Lys Phe Asp Asp His Glu Val Ser Asp Ile Ser Val 
305                 310                 315                 320 


Ser Ser Val Lys Ser Ser Ala Ala Tyr Ile Leu Phe Tyr Thr Ser Leu 
                325                 330                 335     


Gly 
    


<210> 159
<211> 614
<212> PRT
<213> Homo sapiens

<400> 159
Gln Gln Leu Gln Gly Phe Ser Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Ile Leu Gln Ser Leu Phe Ser Leu Gln Ser Phe Ala Asn Asp Leu 
            20                  25                  30          


Leu Lys Gln Gly Ile Pro Trp Lys Lys Ile Pro Leu Asn Ala Leu Ile 
        35                  40                  45              


Arg Arg Phe Ala His Leu Leu Val Lys Lys Asp Ile Cys Asn Ser Glu 
    50                  55                  60                  


Thr Lys Lys Asp Leu Leu Lys Lys Val Lys Asn Ala Ile Ser Ala Thr 
65                  70                  75                  80  


Ala Glu Arg Phe Ser Gly Tyr Met Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Ser Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn Lys 
            100                 105                 110         


Thr Trp Lys Thr Glu Pro Val Ser Gly Glu Glu Asn Ser Pro Asp Ile 
        115                 120                 125             


Ser Ala Thr Arg Ala Tyr Thr Cys Pro Val Ile Thr Asn Leu Glu Phe 
    130                 135                 140                 


Glu Val Gln His Ser Ile Ile Cys Lys Ala Cys Gly Glu Ile Ile Pro 
145                 150                 155                 160 


Lys Arg Glu Gln Phe Asn Asp Leu Ser Ile Asp Leu Pro Arg Arg Lys 
                165                 170                 175     


Lys Pro Leu Pro Pro Arg Ser Ile Gln Asp Ser Leu Asp Leu Phe Phe 
            180                 185                 190         


Arg Ala Glu Glu Leu Glu Tyr Ser Cys Glu Lys Cys Gly Gly Lys Cys 
        195                 200                 205             


Ala Leu Val Arg His Lys Phe Asn Arg Leu Pro Arg Val Leu Ile Leu 
    210                 215                 220                 


His Leu Lys Arg Tyr Ser Phe Asn Val Ala Leu Ser Leu Asn Asn Lys 
225                 230                 235                 240 


Ile Gly Gln Gln Val Ile Ile Pro Arg Tyr Leu Thr Leu Ser Ser His 
                245                 250                 255     


Cys Thr Glu Asn Thr Lys Pro Pro Phe Thr Leu Gly Trp Ser Ala His 
            260                 265                 270         


Met Ala Ile Ser Arg Pro Leu Lys Ala Ser Gln Met Val Asn Ser Cys 
        275                 280                 285             


Ile Thr Ser Pro Ser Thr Pro Ser Lys Lys Phe Thr Phe Lys Ser Lys 
    290                 295                 300                 


Ser Ser Leu Ala Leu Cys Leu Asp Ser Asp Ser Glu Asp Glu Leu Lys 
305                 310                 315                 320 


Arg Ser Val Ala Leu Ser Gln Arg Leu Cys Glu Met Leu Gly Asn Glu 
                325                 330                 335     


Gln Gln Gln Glu Asp Leu Glu Lys Asp Ser Lys Leu Cys Pro Ile Glu 
            340                 345                 350         


Pro Asp Lys Ser Glu Leu Glu Asn Ser Gly Phe Asp Arg Met Ser Glu 
        355                 360                 365             


Glu Glu Leu Leu Ala Ala Val Leu Glu Ile Ser Lys Arg Asp Ala Ser 
    370                 375                 380                 


Pro Ser Leu Ser His Glu Asp Asp Asp Lys Pro Thr Ser Ser Pro Asp 
385                 390                 395                 400 


Thr Gly Phe Ala Glu Asp Asp Ile Gln Glu Met Pro Glu Asn Pro Asp 
                405                 410                 415     


Thr Met Glu Thr Glu Lys Pro Lys Thr Ile Thr Glu Leu Asp Pro Ala 
            420                 425                 430         


Ser Phe Thr Glu Ile Thr Lys Asp Cys Asp Glu Asn Lys Glu Asn Lys 
        435                 440                 445             


Thr Pro Glu Gly Ser Gln Gly Glu Val Asp Trp Leu Gln Gln Tyr Asp 
    450                 455                 460                 


Met Glu Arg Glu Arg Glu Glu Gln Glu Leu Gln Gln Ala Leu Ala Gln 
465                 470                 475                 480 


Ser Leu Gln Glu Gln Glu Ala Trp Glu Gln Lys Glu Asp Asp Asp Leu 
                485                 490                 495     


Lys Arg Ala Thr Glu Leu Ser Leu Gln Glu Phe Asn Asn Ser Phe Val 
            500                 505                 510         


Asp Ala Leu Gly Ser Asp Glu Asp Ser Gly Asn Glu Asp Val Phe Asp 
        515                 520                 525             


Met Glu Tyr Thr Glu Ala Glu Ala Glu Glu Leu Lys Arg Asn Ala Glu 
    530                 535                 540                 


Thr Gly Asn Leu Pro His Ser Tyr Arg Leu Ile Ser Val Val Ser His 
545                 550                 555                 560 


Ile Gly Ser Thr Ser Ser Ser Gly His Tyr Ile Ser Asp Val Tyr Asp 
                565                 570                 575     


Ile Lys Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Glu Val Ser Lys 
            580                 585                 590         


Ile Gln Glu Ala Ala Val Gln Ser Asp Arg Asp Arg Ser Gly Tyr Ile 
        595                 600                 605             


Phe Phe Tyr Met His Lys 
    610                 


<210> 160
<211> 300
<212> PRT
<213> Homo sapiens

<400> 160
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His Pro Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 161
<211> 300
<212> PRT
<213> Homo sapiens

<400> 161
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ser Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 162
<211> 402
<212> PRT
<213> Homo sapiens

<400> 162
Ala Pro Ser Lys Gly Leu Ser Asn Glu Pro Gly Gln Asn Ser Cys Phe 
1               5                   10                  15      


Leu Asn Ser Ala Leu Gln Val Leu Trp His Leu Asp Ile Phe Arg Arg 
            20                  25                  30          


Ser Phe Arg Gln Leu Thr Thr His Lys Cys Met Gly Asp Ser Cys Ile 
        35                  40                  45              


Phe Cys Ala Leu Lys Gly Ile Phe Asn Gln Phe Gln Cys Ser Ser Glu 
    50                  55                  60                  


Lys Val Leu Pro Ser Asp Thr Leu Arg Ser Ala Leu Ala Lys Thr Phe 
65                  70                  75                  80  


Gln Asp Glu Gln Arg Phe Gln Leu Gly Ile Met Asp Asp Ala Ala Glu 
                85                  90                  95      


Cys Phe Glu Asn Leu Leu Met Arg Ile His Phe His Ile Ala Asp Glu 
            100                 105                 110         


Thr Lys Glu Asp Ile Cys Thr Ala Gln His Cys Ile Ser His Gln Lys 
        115                 120                 125             


Phe Ala Met Thr Leu Phe Glu Gln Cys Val Cys Thr Ser Cys Gly Ala 
    130                 135                 140                 


Thr Ser Asp Pro Leu Pro Phe Ile Gln Met Val His Tyr Ile Ser Thr 
145                 150                 155                 160 


Thr Ser Leu Cys Asn Gln Ala Ile Cys Met Leu Glu Arg Arg Glu Lys 
                165                 170                 175     


Pro Ser Pro Ser Met Phe Gly Glu Leu Leu Gln Asn Ala Ser Thr Met 
            180                 185                 190         


Gly Asp Leu Arg Asn Cys Pro Ser Asn Cys Gly Glu Arg Ile Arg Ile 
        195                 200                 205             


Arg Arg Val Leu Met Asn Ala Pro Gln Ile Ile Thr Ile Gly Leu Val 
    210                 215                 220                 


Trp Asp Ser Asp His Ser Asp Leu Ala Glu Asp Val Ile His Ser Leu 
225                 230                 235                 240 


Gly Thr Cys Leu Lys Leu Gly Asp Leu Phe Phe Arg Val Thr Asp Asp 
                245                 250                 255     


Arg Ala Lys Gln Ser Glu Leu Tyr Leu Val Gly Met Ile Cys Tyr Tyr 
            260                 265                 270         


Gly Lys His Tyr Ser Thr Phe Phe Phe Gln Thr Lys Ile Arg Lys Trp 
        275                 280                 285             


Met Tyr Phe Asp Asp Ala His Val Lys Glu Ile Gly Pro Lys Trp Lys 
    290                 295                 300                 


Asp Val Val Thr Lys Cys Ile Lys Gly His Tyr Gln Pro Leu Leu Leu 
305                 310                 315                 320 


Leu Tyr Ala Asp Pro Gln Gly Thr Pro Val Ser Thr Gln Asp Leu Pro 
                325                 330                 335     


Pro Gln Ala Glu Phe Gln Ser Tyr Ser Arg Thr Cys Tyr Asp Ser Glu 
            340                 345                 350         


Asp Ser Gly Arg Glu Pro Ser Ile Ser Ser Asp Thr Arg Thr Asp Ser 
        355                 360                 365             


Ser Thr Glu Ser Tyr Pro Tyr Lys His Ser His His Glu Ser Val Val 
    370                 375                 380                 


Ser His Phe Ser Ser Asp Ser Gln Gly Thr Val Ile Tyr Asn Val Glu 
385                 390                 395                 400 


Asn Asp 
        


<210> 163
<211> 336
<212> PRT
<213> Homo sapiens

<400> 163
Leu Pro Gly Ile Val Gly Leu Asn Asn Ile Lys Ala Asn Asp Tyr Ala 
1               5                   10                  15      


Asn Ala Val Leu Gln Ala Leu Ser Asn Val Pro Pro Leu Arg Asn Tyr 
            20                  25                  30          


Phe Leu Glu Glu Asp Asn Tyr Lys Asn Ile Lys Arg Pro Pro Gly Asp 
        35                  40                  45              


Ile Met Phe Leu Leu Val Gln Arg Phe Gly Glu Leu Met Arg Lys Leu 
    50                  55                  60                  


Trp Asn Pro Arg Asn Phe Lys Ala His Val Ser Pro His Glu Met Leu 
65                  70                  75                  80  


Gln Ala Val Val Leu Cys Ser Lys Lys Thr Phe Gln Ile Thr Lys Gln 
                85                  90                  95      


Gly Asp Gly Val Asp Phe Leu Ser Trp Phe Leu Asn Ala Leu His Ser 
            100                 105                 110         


Ala Leu Gly Gly Thr Lys Lys Lys Lys Lys Thr Ile Val Thr Asp Val 
        115                 120                 125             


Phe Gln Gly Ser Met Arg Ile Phe Thr Lys Lys Leu Pro His Pro Asp 
    130                 135                 140                 


Leu Pro Ala Glu Glu Lys Glu Gln Leu Leu His Asn Asp Glu Tyr Gln 
145                 150                 155                 160 


Glu Thr Met Val Glu Ser Thr Phe Met Tyr Leu Thr Leu Asp Leu Pro 
                165                 170                 175     


Thr Ala Pro Leu Tyr Lys Asp Glu Lys Glu Gln Leu Ile Ile Pro Gln 
            180                 185                 190         


Val Pro Leu Phe Asn Ile Leu Ala Lys Phe Asn Gly Ile Thr Glu Lys 
        195                 200                 205             


Glu Tyr Lys Thr Tyr Lys Glu Asn Phe Leu Lys Arg Phe Gln Leu Thr 
    210                 215                 220                 


Lys Leu Pro Pro Tyr Leu Ile Phe Cys Ile Lys Arg Phe Thr Lys Asn 
225                 230                 235                 240 


Asn Phe Phe Val Glu Lys Asn Pro Thr Ile Val Asn Phe Pro Ile Thr 
                245                 250                 255     


Asn Val Asp Leu Arg Glu Tyr Leu Ser Glu Glu Val Gln Ala Val His 
            260                 265                 270         


Lys Asn Thr Thr Tyr Asp Leu Ile Ala Asn Ile Val His Asp Gly Lys 
        275                 280                 285             


Pro Ser Glu Gly Ser Tyr Arg Ile His Val Leu His His Gly Thr Gly 
    290                 295                 300                 


Lys Trp Tyr Glu Leu Gln Asp Leu Gln Val Thr Asp Ile Leu Pro Gln 
305                 310                 315                 320 


Met Ile Thr Leu Ser Glu Ala Tyr Ile Gln Ile Trp Lys Arg Arg Asp 
                325                 330                 335     


<210> 164
<211> 492
<212> PRT
<213> Homo sapiens

<400> 164
Ser Asp Thr Gly Lys Ile Gly Leu Ile Asn Leu Gly Asn Thr Cys Tyr 
1               5                   10                  15      


Val Asn Ser Ile Leu Gln Ala Leu Phe Met Ala Ser Asp Phe Arg His 
            20                  25                  30          


Cys Val Leu Arg Leu Thr Glu Asn Asn Ser Gln Pro Leu Met Thr Lys 
        35                  40                  45              


Leu Gln Trp Leu Phe Gly Phe Leu Glu His Ser Gln Arg Pro Ala Ile 
    50                  55                  60                  


Ser Pro Glu Asn Phe Leu Ser Ala Ser Trp Thr Pro Trp Phe Ser Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Asp Cys Ser Glu Tyr Leu Lys Tyr Leu Leu Asp Arg 
                85                  90                  95      


Leu His Glu Glu Glu Lys Thr Gly Thr Arg Ile Cys Gln Lys Leu Lys 
            100                 105                 110         


Gln Ser Ser Ser Pro Ser Pro Pro Glu Glu Pro Pro Ala Pro Ser Ser 
        115                 120                 125             


Thr Ser Val Glu Lys Met Phe Gly Gly Lys Ile Val Thr Arg Ile Cys 
    130                 135                 140                 


Cys Leu Cys Cys Leu Asn Val Ser Ser Arg Glu Glu Ala Phe Thr Asp 
145                 150                 155                 160 


Leu Ser Leu Ala Phe Pro Pro Pro Glu Arg Cys Arg Arg Arg Arg Leu 
                165                 170                 175     


Gly Ser Val Met Arg Pro Thr Glu Asp Ile Thr Ala Arg Glu Leu Pro 
            180                 185                 190         


Pro Pro Thr Ser Ala Gln Gly Pro Gly Arg Val Gly Pro Arg Arg Gln 
        195                 200                 205             


Arg Lys His Cys Ile Thr Glu Asp Thr Pro Pro Thr Ser Leu Tyr Ile 
    210                 215                 220                 


Glu Gly Leu Asp Ser Lys Glu Ala Gly Gly Gln Ser Ser Gln Glu Glu 
225                 230                 235                 240 


Arg Ile Glu Arg Glu Glu Glu Gly Lys Glu Glu Arg Thr Glu Lys Glu 
                245                 250                 255     


Glu Val Gly Glu Glu Glu Glu Ser Thr Arg Gly Glu Gly Glu Arg Glu 
            260                 265                 270         


Lys Glu Glu Glu Val Glu Glu Glu Glu Glu Lys Val Glu Lys Glu Thr 
        275                 280                 285             


Glu Lys Glu Ala Glu Gln Glu Lys Glu Glu Asp Ser Leu Gly Ala Gly 
    290                 295                 300                 


Thr His Pro Asp Ala Ala Ile Pro Ser Gly Glu Arg Thr Cys Gly Ser 
305                 310                 315                 320 


Glu Gly Ser Arg Ser Val Leu Asp Leu Val Asn Tyr Phe Leu Ser Pro 
                325                 330                 335     


Glu Lys Leu Thr Ala Glu Asn Arg Tyr Tyr Cys Glu Ser Cys Ala Ser 
            340                 345                 350         


Leu Gln Asp Ala Glu Lys Val Val Glu Leu Ser Gln Gly Pro Cys Tyr 
        355                 360                 365             


Leu Ile Leu Thr Leu Leu Arg Phe Ser Phe Asp Leu Arg Thr Met Arg 
    370                 375                 380                 


Arg Arg Lys Ile Leu Asp Asp Val Ser Ile Pro Leu Leu Leu Arg Leu 
385                 390                 395                 400 


Pro Leu Ala Gly Gly Arg Gly Gln Ala Tyr Asp Leu Cys Ser Val Val 
                405                 410                 415     


Val His Ser Gly Val Ser Ser Glu Ser Gly His Tyr Tyr Cys Tyr Ala 
            420                 425                 430         


Arg Glu Gly Ala Ala Arg Pro Ala Ala Ser Leu Gly Thr Ala Asp Arg 
        435                 440                 445             


Pro Glu Pro Glu Asn Gln Trp Tyr Leu Phe Asn Asp Thr Arg Val Ser 
    450                 455                 460                 


Phe Ser Ser Phe Glu Ser Val Ser Asn Val Thr Ser Phe Phe Pro Lys 
465                 470                 475                 480 


Asp Thr Ala Tyr Val Leu Phe Tyr Arg Gln Arg Pro 
                485                 490         


<210> 165
<211> 651
<212> PRT
<213> Homo sapiens

<400> 165
Glu Gln Pro Gly Leu Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ala Ile Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu 
            20                  25                  30          


Tyr Phe Leu Asn Asp Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro 
        35                  40                  45              


Leu Gly Met Arg Gly Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys 
    50                  55                  60                  


Gln Met Trp Ser Gly Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys 
65                  70                  75                  80  


Thr Gln Val Gly Arg Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln 
                85                  90                  95      


Asp Cys Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp 
            100                 105                 110         


Leu Asn Arg Ile Arg Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp 
        115                 120                 125             


Gly Arg Pro Asp Lys Val Val Ala Glu Glu Ala Trp Glu Asn His Leu 
    130                 135                 140                 


Lys Arg Asn Asp Ser Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys 
145                 150                 155                 160 


Ser Thr Leu Val Cys Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp 
                165                 170                 175     


Pro Phe Cys Tyr Leu Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr 
            180                 185                 190         


Leu Glu Val Tyr Leu Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln 
        195                 200                 205             


Tyr Lys Val Val Val Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr 
    210                 215                 220                 


Ala Leu Ser Ala Leu Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr 
225                 230                 235                 240 


Asp Ile Tyr Asn His Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn 
                245                 250                 255     


Leu Ser Ser Ile Met Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn 
            260                 265                 270         


Ile Asn Arg Thr Glu Asp Thr Glu His Val Ile Ile Pro Val Cys Leu 
        275                 280                 285             


Arg Glu Lys Phe Arg His Ser Ser Tyr Thr His His Thr Gly Ser Ser 
    290                 295                 300                 


Leu Phe Gly Gln Pro Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu 
305                 310                 315                 320 


Asp Lys Leu Tyr Asn Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys 
                325                 330                 335     


Ile Ser Thr Glu Thr Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys 
            340                 345                 350         


Asp Gln Asn Ile Asn Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly 
        355                 360                 365             


Ser Pro Ser Glu Met Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln 
    370                 375                 380                 


Asp Gln Glu Leu Pro Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser 
385                 390                 395                 400 


Val Gly Gly Asp Asn Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr 
                405                 410                 415     


Cys Lys Gly Gln Leu Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln 
            420                 425                 430         


Phe Asn Asn Leu Gly Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr 
        435                 440                 445             


Arg His Ile Arg Phe Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser 
    450                 455                 460                 


Phe Leu Ala Leu Asp Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp 
465                 470                 475                 480 


Glu Asn Ala Ala Glu Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys 
                485                 490                 495     


Pro Pro Lys Lys Pro Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe 
            500                 505                 510         


Thr Thr Lys Glu Lys Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn 
        515                 520                 525             


Cys Lys Glu His Gln Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu 
    530                 535                 540                 


Pro Pro Val Leu Val Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr 
545                 550                 555                 560 


Met Arg Asp Lys Leu Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu 
                565                 570                 575     


Asp Met Ser Glu Phe Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr 
            580                 585                 590         


Asn Leu Ile Ala Val Ser Asn His Tyr Gly Gly Met Gly Gly Gly His 
        595                 600                 605             


Tyr Thr Ala Phe Ala Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe 
    610                 615                 620                 


Asp Asp Ser Ser Val Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys 
625                 630                 635                 640 


Ala Ala Tyr Val Leu Phe Tyr Gln Arg Gln Asp 
                645                 650     


<210> 166
<211> 604
<212> PRT
<213> Homo sapiens

<400> 166
Gln Leu Gln Gln Gly Phe Pro Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Val Leu Gln Ser Leu Phe Ala Ile Pro Ser Phe Ala Asp Asp Leu 
            20                  25                  30          


Leu Thr Gln Gly Val Pro Trp Glu Tyr Ile Pro Phe Glu Ala Leu Ile 
        35                  40                  45              


Met Thr Leu Thr Gln Leu Leu Ala Leu Lys Asp Phe Cys Ser Thr Lys 
    50                  55                  60                  


Ile Lys Arg Glu Leu Leu Gly Asn Val Lys Lys Val Ile Ser Ala Val 
65                  70                  75                  80  


Ala Glu Ile Phe Ser Gly Asn Met Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Gly Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn Ala 
            100                 105                 110         


Thr Leu Asn Thr Gly Lys Glu Cys Gly Asp Glu Asn Ser Ser Pro Gln 
        115                 120                 125             


Met His Val Gly Ser Ala Ala Thr Lys Val Phe Val Cys Pro Val Val 
    130                 135                 140                 


Ala Asn Phe Glu Phe Glu Leu Gln Leu Ser Leu Ile Cys Lys Ala Cys 
145                 150                 155                 160 


Gly His Ala Val Leu Lys Val Glu Pro Asn Asn Tyr Leu Ser Ile Asn 
                165                 170                 175     


Leu His Gln Glu Thr Lys Pro Leu Pro Leu Ser Ile Gln Asn Ser Leu 
            180                 185                 190         


Asp Leu Phe Phe Lys Glu Glu Glu Leu Glu Tyr Asn Cys Gln Met Cys 
        195                 200                 205             


Lys Gln Lys Ser Cys Val Ala Arg His Thr Phe Ser Arg Leu Ser Arg 
    210                 215                 220                 


Val Leu Ile Ile His Leu Lys Arg Tyr Ser Phe Asn Asn Ala Trp Leu 
225                 230                 235                 240 


Leu Val Lys Asn Asn Glu Gln Val Tyr Ile Pro Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Ser Tyr Cys Asn Glu Ser Thr Lys Pro Pro Leu Pro Leu Ser Ser 
            260                 265                 270         


Ser Ala Pro Val Gly Lys Cys Glu Val Leu Glu Val Ser Gln Glu Met 
        275                 280                 285             


Ile Ser Glu Ile Asn Ser Pro Leu Thr Pro Ser Met Lys Leu Thr Ser 
    290                 295                 300                 


Glu Ser Ser Asp Ser Leu Val Leu Pro Val Glu Pro Asp Lys Asn Ala 
305                 310                 315                 320 


Asp Leu Gln Arg Phe Gln Arg Asp Cys Gly Asp Ala Ser Gln Glu Gln 
                325                 330                 335     


His Gln Arg Asp Leu Glu Asn Gly Ser Ala Leu Glu Ser Glu Leu Val 
            340                 345                 350         


His Phe Arg Asp Arg Ala Ile Gly Glu Lys Glu Leu Pro Val Ala Asp 
        355                 360                 365             


Ser Leu Met Asp Gln Gly Asp Ile Ser Leu Pro Val Met Tyr Glu Asp 
    370                 375                 380                 


Gly Gly Lys Leu Ile Ser Ser Pro Asp Thr Arg Leu Val Glu Val His 
385                 390                 395                 400 


Leu Gln Glu Val Pro Gln His Pro Glu Leu Gln Lys Tyr Glu Lys Thr 
                405                 410                 415     


Asn Thr Phe Val Glu Phe Asn Phe Asp Ser Val Thr Glu Ser Thr Asn 
            420                 425                 430         


Gly Phe Tyr Asp Cys Lys Glu Asn Arg Ile Pro Glu Gly Ser Gln Gly 
        435                 440                 445             


Met Ala Glu Gln Leu Gln Gln Cys Ile Glu Glu Ser Ile Ile Asp Glu 
    450                 455                 460                 


Phe Leu Gln Gln Ala Pro Pro Pro Gly Val Arg Lys Leu Asp Ala Gln 
465                 470                 475                 480 


Glu His Thr Glu Glu Thr Leu Asn Gln Ser Thr Glu Leu Arg Leu Gln 
                485                 490                 495     


Lys Ala Asp Leu Asn His Leu Gly Ala Leu Gly Ser Asp Asn Pro Gly 
            500                 505                 510         


Asn Lys Asn Ile Leu Asp Ala Glu Asn Thr Arg Gly Glu Ala Lys Glu 
        515                 520                 525             


Leu Thr Arg Asn Val Lys Met Gly Asp Pro Leu Gln Ala Tyr Arg Leu 
    530                 535                 540                 


Ile Ser Val Val Ser His Ile Gly Ser Ser Pro Asn Ser Gly His Tyr 
545                 550                 555                 560 


Ile Ser Asp Val Tyr Asp Phe Gln Lys Gln Ala Trp Phe Thr Tyr Asn 
                565                 570                 575     


Asp Leu Cys Val Ser Glu Ile Ser Glu Thr Lys Met Gln Glu Ala Arg 
            580                 585                 590         


Leu His Ser Gly Tyr Ile Phe Phe Tyr Met His Asn 
        595                 600                 


<210> 167
<211> 841
<212> PRT
<213> Homo sapiens

<400> 167
Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn 
1               5                   10                  15      


Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe 
            20                  25                  30          


Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly 
        35                  40                  45              


Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu 
    50                  55                  60                  


Trp Ser Gly Thr Gln Lys Ser Val Ala Pro Leu Lys Leu Arg Arg Thr 
65                  70                  75                  80  


Ile Ala Lys Tyr Ala Pro Lys Phe Asp Gly Phe Gln Gln Gln Asp Ser 
                85                  90                  95      


Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn 
            100                 105                 110         


Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg 
        115                 120                 125             


Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg 
    130                 135                 140                 


Asn Arg Ser Ile Ile Val Asp Leu Phe His Gly Gln Leu Arg Ser Gln 
145                 150                 155                 160 


Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Asn 
                165                 170                 175     


Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met Asp Leu Glu Ile 
            180                 185                 190         


Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu Arg 
        195                 200                 205             


Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Arg Asp 
    210                 215                 220                 


Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His Asp 
225                 230                 235                 240 


Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Gln Leu Ser 
                245                 250                 255     


Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Ser Ser Pro 
            260                 265                 270         


Ile Ser Ala Ser Ser Pro Thr Gln Ile Asp Phe Ser Ser Ser Pro Ser 
        275                 280                 285             


Thr Asn Gly Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Lys Pro 
    290                 295                 300                 


Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly Thr 
305                 310                 315                 320 


Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser Leu 
                325                 330                 335     


Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys Met 
            340                 345                 350         


Met Arg Thr Glu Leu Tyr Phe Leu Ser Pro Gln Glu Asn Arg Pro Ser 
        355                 360                 365             


Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg Lys 
    370                 375                 380                 


Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Trp Leu Ala Arg 
385                 390                 395                 400 


Pro Leu Pro Pro Gln Glu Ala Ser Ile His Ala Gln Asp Arg Asp Asn 
                405                 410                 415     


Cys Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys Asp 
            420                 425                 430         


Gly Asn Ser Cys Ala Trp Cys Pro Gln Tyr Arg Phe Cys Arg Gly Cys 
        435                 440                 445             


Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr Ile 
    450                 455                 460                 


Ala Val Asp Trp His Pro Thr Ala Leu His Leu Arg Tyr Gln Thr Ser 
465                 470                 475                 480 


Gln Glu Arg Val Val Asp Lys His Glu Ser Val Glu Gln Ser Arg Arg 
                485                 490                 495     


Ala Gln Ala Glu Pro Ile Asn Leu Asp Ser Cys Leu Arg Ala Phe Thr 
            500                 505                 510         


Ser Glu Glu Glu Leu Gly Glu Ser Glu Met Tyr Tyr Cys Ser Lys Cys 
        515                 520                 525             


Lys Thr His Cys Leu Ala Thr Lys Lys Leu Asp Leu Trp Arg Leu Pro 
    530                 535                 540                 


Pro Phe Leu Ile Ile His Leu Lys Arg Phe Gln Phe Val Asn Asp Gln 
545                 550                 555                 560 


Trp Ile Lys Ser Gln Lys Ile Val Arg Phe Leu Arg Glu Ser Phe Asp 
                565                 570                 575     


Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu Cys Gln His Lys 
            580                 585                 590         


Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Lys Pro Arg Ile Leu Ala 
        595                 600                 605             


Arg Glu Val Lys Lys Val Asp Ala Gln Ser Ser Ala Gly Lys Glu Asp 
    610                 615                 620                 


Met Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn Ile Ser Ser 
625                 630                 635                 640 


Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser Gly Thr Ser Cys 
                645                 650                 655     


Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Ser Pro Arg Thr Leu Gly 
            660                 665                 670         


Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly Ser Lys Asn Lys 
        675                 680                 685             


Pro Ser Ser Ser Lys Lys Asn Leu Asp Ala Ser Lys Glu Asn Gly Ala 
    690                 695                 700                 


Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser Arg Gly His Met Arg 
705                 710                 715                 720 


Gly Gly Ser Gln Pro Glu Leu Val Thr Pro Gln Asp His Glu Val Ala 
                725                 730                 735     


Leu Ala Asn Gly Phe Leu Tyr Glu His Glu Ala Cys Gly Asn Gly Cys 
            740                 745                 750         


Gly Asp Gly Tyr Ser Asn Gly Gln Leu Gly Asn His Ser Glu Glu Asp 
        755                 760                 765             


Ser Thr Asp Asp Gln Arg Glu Asp Thr His Ile Lys Pro Ile Tyr Asn 
    770                 775                 780                 


Leu Tyr Ala Ile Ser Cys His Ser Gly Ile Leu Ser Gly Gly His Tyr 
785                 790                 795                 800 


Ile Thr Tyr Ala Lys Asn Pro Asn Cys Lys Trp Tyr Cys Tyr Asn Asp 
                805                 810                 815     


Ser Ser Cys Glu Glu Leu His Pro Asp Glu Ile Asp Thr Asp Ser Ala 
            820                 825                 830         


Tyr Ile Leu Phe Tyr Glu Gln Gln Gly 
        835                 840     


<210> 168
<211> 446
<212> PRT
<213> Homo sapiens

<400> 168
Ala Pro Thr Lys Gly Leu Leu Asn Glu Pro Gly Gln Asn Ser Cys Phe 
1               5                   10                  15      


Leu Asn Ser Ala Val Gln Val Leu Trp Gln Leu Asp Ile Phe Arg Arg 
            20                  25                  30          


Ser Leu Arg Val Leu Thr Gly His Val Cys Gln Gly Asp Ala Cys Ile 
        35                  40                  45              


Phe Cys Ala Leu Lys Thr Ile Phe Ala Gln Phe Gln His Ser Arg Glu 
    50                  55                  60                  


Lys Ala Leu Pro Ser Asp Asn Ile Arg His Ala Leu Ala Glu Ser Phe 
65                  70                  75                  80  


Lys Asp Glu Gln Arg Phe Gln Leu Gly Leu Met Asp Asp Ala Ala Glu 
                85                  90                  95      


Cys Phe Glu Asn Met Leu Glu Arg Ile His Phe His Ile Val Pro Ser 
            100                 105                 110         


Arg Asp Ala Asp Met Cys Thr Ser Lys Ser Cys Ile Thr His Gln Lys 
        115                 120                 125             


Phe Ala Met Thr Leu Tyr Glu Gln Cys Val Cys Arg Ser Cys Gly Ala 
    130                 135                 140                 


Ser Ser Asp Pro Leu Pro Phe Thr Glu Phe Val Arg Tyr Ile Ser Thr 
145                 150                 155                 160 


Thr Ala Leu Cys Asn Glu Val Glu Arg Met Leu Glu Arg His Glu Arg 
                165                 170                 175     


Phe Lys Pro Glu Met Phe Ala Glu Leu Leu Gln Ala Ala Asn Thr Thr 
            180                 185                 190         


Asp Asp Tyr Arg Lys Cys Pro Ser Asn Cys Gly Gln Lys Ile Lys Ile 
        195                 200                 205             


Arg Arg Val Leu Met Asn Cys Pro Glu Ile Val Thr Ile Gly Leu Val 
    210                 215                 220                 


Trp Asp Ser Glu His Ser Asp Leu Thr Glu Ala Val Val Arg Asn Leu 
225                 230                 235                 240 


Ala Thr His Leu Tyr Leu Pro Gly Leu Phe Tyr Arg Val Thr Asp Glu 
                245                 250                 255     


Asn Ala Lys Asn Ser Glu Leu Asn Leu Val Gly Met Ile Cys Tyr Thr 
            260                 265                 270         


Ser Gln His Tyr Cys Ala Phe Ala Phe His Thr Lys Ser Ser Lys Trp 
        275                 280                 285             


Val Phe Phe Asp Asp Ala Asn Val Lys Glu Ile Gly Thr Arg Trp Lys 
    290                 295                 300                 


Asp Val Val Ser Lys Cys Ile Arg Cys His Phe Gln Pro Leu Leu Leu 
305                 310                 315                 320 


Phe Tyr Ala Asn Pro Asp Gly Thr Ala Val Ser Thr Glu Asp Ala Leu 
                325                 330                 335     


Arg Gln Val Ile Ser Trp Ser His Tyr Lys Ser Val Ala Glu Asn Met 
            340                 345                 350         


Gly Cys Glu Lys Pro Val Ile His Lys Ser Asp Asn Leu Lys Glu Asn 
        355                 360                 365             


Gly Phe Gly Asp Gln Ala Lys Gln Arg Glu Asn Gln Lys Phe Pro Thr 
    370                 375                 380                 


Asp Asn Ile Ser Ser Ser Asn Arg Ser His Ser His Thr Gly Val Gly 
385                 390                 395                 400 


Lys Gly Pro Ala Lys Leu Ser His Ile Asp Gln Arg Glu Lys Ile Lys 
                405                 410                 415     


Asp Ile Ser Arg Glu Cys Ala Leu Lys Ala Ile Glu Gln Lys Asn Leu 
            420                 425                 430         


Leu Ser Ser Gln Arg Lys Asp Leu Glu Lys Gly Gln Arg Lys 
        435                 440                 445     


<210> 169
<211> 600
<212> PRT
<213> Homo sapiens

<400> 169
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Ala Val Gly Ala 
    290                 295                 300                 


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
305                 310                 315                 320 


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
                325                 330                 335     


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
            340                 345                 350         


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
        355                 360                 365             


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
    370                 375                 380                 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
385                 390                 395                 400 


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
                405                 410                 415     


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
            420                 425                 430         


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
        435                 440                 445             


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
    450                 455                 460                 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
465                 470                 475                 480 


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
                485                 490                 495     


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
            500                 505                 510         


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
        515                 520                 525             


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
    530                 535                 540                 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
545                 550                 555                 560 


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
                565                 570                 575     


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
            580                 585                 590         


Val Leu Phe Tyr Ile Gln Lys Ser 
        595                 600 


<210> 170
<211> 1020
<212> PRT
<213> Homo sapiens

<400> 170
Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            20                  25                  30          


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        35                  40                  45              


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    50                  55                  60                  


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
65                  70                  75                  80  


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                85                  90                  95      


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            100                 105                 110         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        115                 120                 125             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    130                 135                 140                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
145                 150                 155                 160 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                165                 170                 175     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            180                 185                 190         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        195                 200                 205             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    210                 215                 220                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
225                 230                 235                 240 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                245                 250                 255     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            260                 265                 270         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        275                 280                 285             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    290                 295                 300                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
305                 310                 315                 320 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                325                 330                 335     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            340                 345                 350         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        355                 360                 365             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    370                 375                 380                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
385                 390                 395                 400 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                405                 410                 415     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            420                 425                 430         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        435                 440                 445             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    450                 455                 460                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
465                 470                 475                 480 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                485                 490                 495     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            500                 505                 510         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        515                 520                 525             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Lys Ala Pro Val Gly Leu Lys 
    530                 535                 540                 


Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe 
545                 550                 555                 560 


Asn Leu Leu Glu Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser 
                565                 570                 575     


Asn Ala Gln Asp Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro 
            580                 585                 590         


Phe Met Arg Glu Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys 
        595                 600                 605             


Arg Lys Tyr Val Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala 
    610                 615                 620                 


Phe Lys Ser Asn Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His 
625                 630                 635                 640 


Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu 
                645                 650                 655     


Glu Thr Asp Glu Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr 
            660                 665                 670         


Gly Arg Phe Leu Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn 
        675                 680                 685             


Thr Glu Met Phe Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp 
    690                 695                 700                 


Leu His Glu Cys Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser 
705                 710                 715                 720 


Leu His Ser Glu Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr 
                725                 730                 735     


Glu Leu Pro Pro Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn 
            740                 745                 750         


Gln Ala Leu Gly Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro 
        755                 760                 765             


Gln Val Leu Tyr Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr 
    770                 775                 780                 


Arg Ile Lys Arg Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val 
785                 790                 795                 800 


Leu Gln Gln Arg Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys 
                805                 810                 815     


Arg Phe Pro Leu Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser 
            820                 825                 830         


Ser Lys Pro Val Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser 
        835                 840                 845             


Pro Pro Ser Gly Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu 
    850                 855                 860                 


Gln Gln Gly Ala Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser 
865                 870                 875                 880 


Val Ala Ala Ile Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln 
                885                 890                 895     


Ser Arg Ile Pro Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile 
            900                 905                 910         


Thr Glu Glu Glu Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg 
        915                 920                 925             


Thr Glu Ile Glu Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg 
    930                 935                 940                 


Ile His Arg Thr Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln 
945                 950                 955                 960 


Val Pro Tyr Arg Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn 
                965                 970                 975     


Ala Gly His Tyr Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp 
            980                 985                 990         


Met Lys Tyr Asn Asp Ile Ala Val  Thr Lys Ser Ser Trp  Glu Glu Leu 
        995                 1000                 1005             


Val Arg  Asp Ser Phe Gly Gly  Tyr Arg Asn Ala Ser  
    1010                 1015                 1020 


<210> 171
<211> 536
<212> PRT
<213> Homo sapiens

<400> 171
Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn Thr Cys Tyr Met 
1               5                   10                  15      


Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe 
            20                  25                  30          


Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys Lys Pro Ala Ile 
        35                  40                  45              


Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp His Lys Ser Arg 
    50                  55                  60                  


Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly Ile Lys Thr Val 
65                  70                  75                  80  


Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe Leu 
                85                  90                  95      


Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys Glu Gln Val Met 
            100                 105                 110         


Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu Glu Thr Met Glu 
        115                 120                 125             


Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser Cys Glu Ser Cys 
    130                 135                 140                 


Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser Arg Cys Phe Ser 
145                 150                 155                 160 


Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp Asp Glu Asn Asn 
                165                 170                 175     


Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met Cys Asn Lys Ile 
            180                 185                 190         


Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp Arg Asp Ser Ile 
        195                 200                 205             


Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val Lys Val Gln Ile 
    210                 215                 220                 


His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His Ser Asn Asp Leu 
225                 230                 235                 240 


Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val Asn Pro Arg Leu 
                245                 250                 255     


Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro Gly Leu Ala Pro 
            260                 265                 270         


Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg Lys Lys Gln His 
        275                 280                 285             


Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp Gly Thr Ile Ile 
    290                 295                 300                 


Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser Val Thr Leu Glu 
305                 310                 315                 320 


Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys Glu Asp Leu Ala 
                325                 330                 335     


Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val Lys Ala Gly Ser 
            340                 345                 350         


Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala Phe Phe Met Glu 
        355                 360                 365             


Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro Ser Trp Phe Trp Gly 
    370                 375                 380                 


Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala Phe Phe Ala Arg Asp 
385                 390                 395                 400 


Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu Lys Cys Lys Lys Leu 
                405                 410                 415     


Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn Phe Pro Glu Ile Leu 
            420                 425                 430         


Cys Ile His Leu Lys Arg Phe Arg His Glu Leu Met Phe Ser Thr Lys 
        435                 440                 445             


Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly Leu Asp Leu Gln Pro 
    450                 455                 460                 


Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val Thr Tyr Asp Leu Leu 
465                 470                 475                 480 


Ser Val Ile Cys His His Gly Thr Ala Ser Ser Gly His Tyr Ile Ala 
                485                 490                 495     


Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr Glu Phe Asp Asp Gln 
            500                 505                 510         


Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln Asn Ala Glu Ala Tyr 
        515                 520                 525             


Val Leu Phe Tyr Arg Lys Ser Ser 
    530                 535     


<210> 172
<211> 353
<212> PRT
<213> Homo sapiens

<400> 172
Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp 
            20                  25                  30          


Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg 
        35                  40                  45              


Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp 
    50                  55                  60                  


His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val 
65                  70                  75                  80  


Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn 
            100                 105                 110         


Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro 
        115                 120                 125             


Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser 
    130                 135                 140                 


Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu 
145                 150                 155                 160 


Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu 
                165                 170                 175     


Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys 
            180                 185                 190         


Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val 
        195                 200                 205             


Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu 
    210                 215                 220                 


Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser 
225                 230                 235                 240 


Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His 
                245                 250                 255     


Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val 
            260                 265                 270         


Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His 
    290                 295                 300                 


Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln 
305                 310                 315                 320 


Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu 
                325                 330                 335     


Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met 
            340                 345                 350         


Gln 
    


<210> 173
<211> 300
<212> PRT
<213> Homo sapiens

<400> 173
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly Tyr Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 174
<211> 300
<212> PRT
<213> Homo sapiens

<400> 174
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 175
<211> 334
<212> PRT
<213> Homo sapiens

<400> 175
Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn 
1               5                   10                  15      


Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Lys Val 
            20                  25                  30          


Leu Ala Tyr Lys Ser Gln Pro Arg Lys Lys Glu Ser Leu Leu Thr Cys 
        35                  40                  45              


Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly 
    50                  55                  60                  


Val Ile Pro Pro Lys Lys Phe Ile Thr Arg Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr 
                85                  90                  95      


Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Arg Lys Gln Glu 
            100                 105                 110         


Lys Gln Asn Gly Arg Leu Pro Asn Gly Asn Ile Asp Asn Glu Asn Asn 
        115                 120                 125             


Asn Ser Thr Pro Asp Pro Thr Trp Val His Glu Ile Phe Gln Gly Thr 
    130                 135                 140                 


Leu Thr Asn Glu Thr Arg Cys Leu Thr Cys Glu Thr Ile Ser Ser Lys 
145                 150                 155                 160 


Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser 
                165                 170                 175     


Ile Thr His Cys Leu Arg Gly Phe Ser Asn Thr Glu Thr Leu Cys Ser 
            180                 185                 190         


Glu Tyr Lys Tyr Tyr Cys Glu Glu Cys Arg Ser Lys Gln Glu Ala His 
        195                 200                 205             


Lys Arg Met Lys Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu 
    210                 215                 220                 


Lys Arg Phe Lys Tyr Met Asp Gln Leu His Arg Tyr Thr Lys Leu Ser 
225                 230                 235                 240 


Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Gly 
                245                 250                 255     


Asp Ala Thr Asn Pro Asp Arg Met Tyr Asp Leu Val Ala Val Val Val 
            260                 265                 270         


His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Ala Ile Val Lys 
        275                 280                 285             


Ser His Asp Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile 
    290                 295                 300                 


Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser 
305                 310                 315                 320 


Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg 
                325                 330                 


<210> 176
<211> 300
<212> PRT
<213> Homo sapiens

<400> 176
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Leu Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 177
<211> 546
<212> PRT
<213> Homo sapiens

<400> 177
Pro Arg Gly Leu Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met 
1               5                   10                  15      


Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe 
            20                  25                  30          


Phe Leu Glu Cys Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu 
        35                  40                  45              


Cys Lys Ser Tyr Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg 
    50                  55                  60                  


Pro Ser Tyr Val Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val 
65                  70                  75                  80  


Asn Pro Met Phe Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu 
                85                  90                  95      


Arg Cys Leu Met Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val 
            100                 105                 110         


Ala Thr Val Ala Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr 
        115                 120                 125             


Asp Glu Lys Arg Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu 
    130                 135                 140                 


Ser Cys Asp Ser Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg 
145                 150                 155                 160 


Gly Gly Gly Ser Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu 
                165                 170                 175     


Ala Gly Arg Ala Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe 
            180                 185                 190         


Ser Trp Gly Gln Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala 
        195                 200                 205             


Asp Val Asp Thr Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala 
    210                 215                 220                 


Gln Pro Pro Ser Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro 
225                 230                 235                 240 


Asp Asn Asp Ala His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val 
                245                 250                 255     


His His His Glu Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala 
            260                 265                 270         


Ser Pro Val Arg Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val 
        275                 280                 285             


Leu Ser Ala Gly Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val 
    290                 295                 300                 


Ile Ser Asp Ile Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu 
305                 310                 315                 320 


Thr Cys Asp Arg Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser 
                325                 330                 335     


Leu Pro Ile Pro Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile 
            340                 345                 350         


Tyr Gln Asn Val Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala 
        355                 360                 365             


Ala Gln Gly Trp Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val 
    370                 375                 380                 


Val Ser Cys Thr Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu 
385                 390                 395                 400 


Asp Cys Leu Ala Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn 
                405                 410                 415     


Met Tyr Ser Cys Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr 
            420                 425                 430         


Cys Lys Val Leu Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg 
        435                 440                 445             


Phe Arg His Glu Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser 
    450                 455                 460                 


Phe Pro Leu Glu Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys 
465                 470                 475                 480 


Thr Ser Gln Ile Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His 
                485                 490                 495     


Gly Thr Ala Gly Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile 
            500                 505                 510         


Asn Gly Gln Trp Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His 
        515                 520                 525             


Glu Thr Val Val Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys 
    530                 535                 540                 


Ser Ser 
545     


<210> 178
<211> 334
<212> PRT
<213> Homo sapiens

<400> 178
Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn 
1               5                   10                  15      


Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Asn Val 
            20                  25                  30          


Leu Ala Tyr Lys Ala Gln Gln Lys Lys Lys Glu Asn Leu Leu Thr Cys 
        35                  40                  45              


Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly 
    50                  55                  60                  


Val Ile Pro Pro Lys Lys Phe Ile Ser Arg Leu Arg Lys Glu Asn Asp 
65                  70                  75                  80  


Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr 
                85                  90                  95      


Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Lys Lys Gln Glu 
            100                 105                 110         


Lys Gln Asn Gly Lys Leu Lys Asn Gly Asn Met Asn Glu Pro Ala Glu 
        115                 120                 125             


Asn Asn Lys Pro Glu Leu Thr Trp Val His Glu Ile Phe Gln Gly Thr 
    130                 135                 140                 


Leu Thr Asn Glu Thr Arg Cys Leu Asn Cys Glu Thr Val Ser Ser Lys 
145                 150                 155                 160 


Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser 
                165                 170                 175     


Ile Thr His Cys Leu Arg Asp Phe Ser Asn Thr Glu Thr Leu Cys Ser 
            180                 185                 190         


Glu Gln Lys Tyr Tyr Cys Glu Thr Cys Cys Ser Lys Gln Glu Ala Gln 
        195                 200                 205             


Lys Arg Met Arg Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu 
    210                 215                 220                 


Lys Arg Phe Lys Tyr Met Glu Gln Leu His Arg Tyr Thr Lys Leu Ser 
225                 230                 235                 240 


Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Ser 
                245                 250                 255     


Asp Ala Val Asn Leu Asp Arg Met Tyr Asp Leu Val Ala Val Val Val 
            260                 265                 270         


His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Thr Ile Val Lys 
        275                 280                 285             


Ser His Gly Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile 
    290                 295                 300                 


Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser 
305                 310                 315                 320 


Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg 
                325                 330                 


<210> 179
<211> 363
<212> PRT
<213> Homo sapiens

<400> 179
Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp 
1               5                   10                  15      


Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Thr Val 
            20                  25                  30          


Leu Leu Arg Pro Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Thr 
        35                  40                  45              


Gln Glu Leu Leu Arg Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly 
    50                  55                  60                  


Tyr Val Cys Ala Thr Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys 
65                  70                  75                  80  


Val Glu Ala Ala Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu 
                85                  90                  95      


Phe Leu Asn Ile Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu 
            100                 105                 110         


Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln 
        115                 120                 125             


Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln 
    130                 135                 140                 


Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala 
145                 150                 155                 160 


Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys 
                165                 170                 175     


Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu 
            180                 185                 190         


Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met 
        195                 200                 205             


Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys 
    210                 215                 220                 


Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr Gln Val His Leu His Pro 
225                 230                 235                 240 


Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu 
                245                 250                 255     


Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu 
            260                 265                 270         


Leu Phe Ala Val Leu Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val 
        275                 280                 285             


Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala 
    290                 295                 300                 


Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro 
305                 310                 315                 320 


Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His 
                325                 330                 335     


Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys 
            340                 345                 350         


Asp Ala Tyr Met Cys Met Tyr Gln Ser Pro Thr 
        355                 360             


<210> 180
<211> 631
<212> PRT
<213> Homo sapiens

<400> 180
Ile Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn 
1               5                   10                  15      


Ala Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu 
            20                  25                  30          


Lys Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp 
        35                  40                  45              


Leu Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro 
    50                  55                  60                  


Leu Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys 
65                  70                  75                  80  


Lys Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys 
                85                  90                  95      


Ala Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu 
            100                 105                 110         


Arg Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser 
        115                 120                 125             


Lys Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu 
    130                 135                 140                 


Glu Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro 
145                 150                 155                 160 


Ser Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met 
                165                 170                 175     


Cys Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp 
            180                 185                 190         


Leu Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn 
        195                 200                 205             


Asp Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu 
    210                 215                 220                 


Glu Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro 
225                 230                 235                 240 


Ser Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys 
                245                 250                 255     


Lys Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val 
            260                 265                 270         


Leu His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu 
        275                 280                 285             


Tyr Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn 
    290                 295                 300                 


His Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln 
305                 310                 315                 320 


Lys Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn 
                325                 330                 335     


Gln Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn 
            340                 345                 350         


Asp Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala 
        355                 360                 365             


Tyr Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe 
    370                 375                 380                 


Lys Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile 
385                 390                 395                 400 


Glu Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val 
                405                 410                 415     


Val Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu 
            420                 425                 430         


Val Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe 
        435                 440                 445             


Thr Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val 
    450                 455                 460                 


Cys Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu 
465                 470                 475                 480 


Arg Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu 
                485                 490                 495     


Ala Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly 
            500                 505                 510         


Phe Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu 
        515                 520                 525             


Asp Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu 
    530                 535                 540                 


Asn Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly 
545                 550                 555                 560 


Thr Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala 
                565                 570                 575     


Asn Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp 
            580                 585                 590         


Phe Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His 
        595                 600                 605             


Val Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu 
    610                 615                 620                 


Leu Phe Tyr Glu Arg Ile Leu 
625                 630     


<210> 181
<211> 291
<212> PRT
<213> Homo sapiens

<400> 181
Tyr Arg Tyr Lys Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu 
1               5                   10                  15      


Val Ile Ser His Ala Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys 
            20                  25                  30          


Gly Lys Pro Leu Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His 
        35                  40                  45              


Gln Leu Glu Leu Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr 
    50                  55                  60                  


Cys Thr Cys Arg Val Leu Thr Cys Pro Gly Gln Ala Lys Ser Ile Ala 
65                  70                  75                  80  


Ser Ala Pro Gly Lys Cys Gln Asp Ser Ala Ala Leu Thr Ser Thr Ala 
                85                  90                  95      


Phe Ser Gly Leu Asp Phe Gly Leu Leu Ser Gly Tyr Leu His Lys Gln 
            100                 105                 110         


Ala Leu Val Thr Ala Thr His Pro Thr Cys Thr Leu Leu Phe Pro Ser 
        115                 120                 125             


Cys His Ala Phe Phe Pro Leu Pro Leu Thr Pro Thr Leu Tyr Lys Met 
    130                 135                 140                 


His Lys Gly Trp Lys Asn Tyr Cys Ser Gln Lys Ser Leu Asn Glu Ala 
145                 150                 155                 160 


Ser Met Asp Glu Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr 
                165                 170                 175     


Ala Lys Asp Ala Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe 
            180                 185                 190         


Cys Ser Gln Val His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr 
        195                 200                 205             


Met Arg Glu Asn Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe 
    210                 215                 220                 


Glu Lys Tyr Leu Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln 
225                 230                 235                 240 


Leu Glu Ile Arg Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu 
                245                 250                 255     


Tyr Arg Phe Pro Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr 
            260                 265                 270         


Glu Asp Lys Ile Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser 
        275                 280                 285             


Val Tyr Ser 
    290     


<210> 182
<211> 212
<212> PRT
<213> Homo sapiens

<400> 182
Gln Gly Leu Ser Ser Arg Thr Arg Val Arg Glu Leu Gln Gly Gln Ile 
1               5                   10                  15      


Ala Ala Ile Thr Gly Ile Ala Pro Gly Gly Gln Arg Ile Leu Val Gly 
            20                  25                  30          


Tyr Pro Pro Glu Cys Leu Asp Leu Ser Asn Gly Asp Thr Ile Leu Glu 
        35                  40                  45              


Asp Leu Pro Ile Gln Ser Gly Asp Met Leu Ile Ile Glu Glu Asp Gln 
    50                  55                  60                  


Thr Arg Pro Arg Ser Ser Pro Ala Phe Thr Lys Arg Gly Ala Ser Ser 
65                  70                  75                  80  


Tyr Val Arg Glu Thr Leu Pro Val Leu Thr Arg Thr Val Val Pro Ala 
                85                  90                  95      


Asp Asn Ser Cys Leu Phe Thr Ser Val Tyr Tyr Val Val Glu Gly Gly 
            100                 105                 110         


Val Leu Asn Pro Ala Cys Ala Pro Glu Met Arg Arg Leu Ile Ala Gln 
        115                 120                 125             


Ile Val Ala Ser Asp Pro Asp Phe Tyr Ser Glu Ala Ile Leu Gly Lys 
    130                 135                 140                 


Thr Asn Gln Glu Tyr Cys Asp Trp Ile Lys Arg Asp Asp Thr Trp Gly 
145                 150                 155                 160 


Gly Ala Ile Glu Ile Ser Ile Leu Ser Lys Phe Tyr Gln Cys Glu Ile 
                165                 170                 175     


Cys Val Val Asp Thr Gln Thr Val Arg Ile Asp Arg Phe Gly Glu Asp 
            180                 185                 190         


Ala Gly Tyr Thr Lys Arg Val Leu Leu Ile Tyr Asp Gly Ile His Tyr 
        195                 200                 205             


Asp Pro Leu Gln 
    210         


<210> 183
<211> 375
<212> PRT
<213> Homo sapiens

<400> 183
His Arg Glu Ala Ala Ala Val Pro Ala Ala Lys Met Pro Ala Phe Ser 
1               5                   10                  15      


Ser Cys Phe Glu Val Val Ser Gly Ala Ala Ala Pro Ala Ser Ala Ala 
            20                  25                  30          


Ala Gly Pro Pro Gly Ala Ser Cys Lys Pro Pro Leu Pro Pro His Tyr 
        35                  40                  45              


Thr Ser Thr Ala Gln Ile Thr Val Arg Ala Leu Gly Ala Asp Arg Leu 
    50                  55                  60                  


Leu Leu His Gly Pro Asp Pro Val Pro Gly Ala Ala Gly Ser Ala Ala 
65                  70                  75                  80  


Ala Pro Arg Gly Arg Cys Leu Leu Leu Ala Pro Ala Pro Ala Ala Pro 
                85                  90                  95      


Val Pro Pro Arg Arg Gly Ser Ser Ala Trp Leu Leu Glu Glu Leu Leu 
            100                 105                 110         


Arg Pro Asp Cys Pro Glu Pro Ala Gly Leu Asp Ala Thr Arg Glu Gly 
        115                 120                 125             


Pro Asp Arg Asn Phe Arg Leu Ser Glu His Arg Gln Ala Leu Ala Ala 
    130                 135                 140                 


Ala Lys His Arg Gly Pro Ala Ala Thr Pro Gly Ser Pro Asp Pro Gly 
145                 150                 155                 160 


Pro Gly Pro Trp Gly Glu Glu His Leu Ala Glu Arg Gly Pro Arg Gly 
                165                 170                 175     


Trp Glu Arg Gly Gly Asp Arg Cys Asp Ala Pro Gly Gly Asp Ala Ala 
            180                 185                 190         


Arg Arg Pro Asp Pro Glu Ala Glu Ala Pro Pro Ala Gly Ser Ile Glu 
        195                 200                 205             


Ala Ala Pro Ser Ser Ala Ala Glu Pro Val Ile Val Ser Arg Ser Asp 
    210                 215                 220                 


Pro Arg Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln 
225                 230                 235                 240 


Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro 
                245                 250                 255     


Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp 
            260                 265                 270         


Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala 
        275                 280                 285             


Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu 
    290                 295                 300                 


Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu 
305                 310                 315                 320 


Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr 
                325                 330                 335     


Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu 
            340                 345                 350         


Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser 
        355                 360                 365             


Asn Gly His Tyr Asp Ala Val 
    370                 375 


<210> 184
<211> 213
<212> PRT
<213> Homo sapiens

<400> 184
Gln Lys His Arg Glu Glu Leu Glu Gln Leu Lys Leu Thr Thr Lys Glu 
1               5                   10                  15      


Asn Lys Ile Asp Ser Val Ala Val Asn Ile Ser Asn Leu Val Leu Glu 
            20                  25                  30          


Asn Gln Pro Pro Arg Ile Ser Lys Ala Gln Lys Arg Arg Glu Lys Lys 
        35                  40                  45              


Ala Ala Leu Glu Lys Glu Arg Glu Glu Arg Ile Ala Glu Ala Glu Ile 
    50                  55                  60                  


Glu Asn Leu Thr Gly Ala Arg His Met Glu Ser Glu Lys Leu Ala Gln 
65                  70                  75                  80  


Ile Leu Ala Ala Arg Gln Leu Glu Ile Lys Gln Ile Pro Ser Asp Gly 
                85                  90                  95      


His Cys Met Tyr Lys Ala Ile Glu Asp Gln Leu Lys Glu Lys Asp Cys 
            100                 105                 110         


Ala Leu Thr Val Val Ala Leu Arg Ser Gln Thr Ala Glu Tyr Met Gln 
        115                 120                 125             


Ser His Val Glu Asp Phe Leu Pro Phe Leu Thr Asn Pro Asn Thr Gly 
    130                 135                 140                 


Asp Met Tyr Thr Pro Glu Glu Phe Gln Lys Tyr Cys Glu Asp Ile Val 
145                 150                 155                 160 


Asn Thr Ala Ala Trp Gly Gly Gln Leu Glu Leu Arg Ala Leu Ser His 
                165                 170                 175     


Ile Leu Gln Thr Pro Ile Glu Ile Ile Gln Ala Asp Ser Pro Pro Ile 
            180                 185                 190         


Ile Val Gly Glu Glu Tyr Ser Lys Lys Pro Leu Ile Leu Val Tyr Met 
        195                 200                 205             


Arg His Ala Tyr Gly 
    210             


<210> 185
<211> 204
<212> PRT
<213> Homo sapiens

<400> 185
Gln Glu Leu Glu Lys Phe Gln Asp Asp Ser Ser Ile Glu Ser Val Val 
1               5                   10                  15      


Glu Asp Leu Ala Lys Met Asn Leu Glu Asn Arg Pro Pro Arg Ser Ser 
            20                  25                  30          


Lys Ala His Arg Lys Arg Glu Arg Met Glu Ser Glu Glu Arg Glu Arg 
        35                  40                  45              


Gln Glu Ser Ile Phe Gln Ala Glu Met Ser Glu His Leu Ala Gly Phe 
    50                  55                  60                  


Lys Arg Glu Glu Glu Glu Lys Leu Ala Ala Ile Leu Gly Ala Arg Gly 
65                  70                  75                  80  


Leu Glu Met Lys Ala Ile Pro Ala Asp Gly His Cys Met Tyr Arg Ala 
                85                  90                  95      


Ile Gln Asp Gln Leu Val Phe Ser Val Ser Val Glu Met Leu Arg Cys 
            100                 105                 110         


Arg Thr Ala Ser Tyr Met Lys Lys His Val Asp Glu Phe Leu Pro Phe 
        115                 120                 125             


Phe Ser Asn Pro Glu Thr Ser Asp Ser Phe Gly Tyr Asp Asp Phe Met 
    130                 135                 140                 


Ile Tyr Cys Asp Asn Ile Val Arg Thr Thr Ala Trp Gly Gly Gln Leu 
145                 150                 155                 160 


Glu Leu Arg Ala Leu Ser His Val Leu Lys Thr Pro Ile Glu Val Ile 
                165                 170                 175     


Gln Ala Asp Ser Pro Thr Leu Ile Ile Gly Glu Glu Tyr Val Lys Lys 
            180                 185                 190         


Pro Ile Ile Leu Val Tyr Leu Arg Tyr Ala Tyr Ser 
        195                 200                 


<210> 186
<211> 311
<212> PRT
<213> Homo sapiens

<400> 186
Ser Asp Tyr Glu Gln Leu Arg Gln Val His Thr Ala Asn Leu Pro His 
1               5                   10                  15      


Val Phe Asn Glu Gly Arg Gly Pro Lys Gln Pro Glu Arg Glu Pro Gln 
            20                  25                  30          


Pro Gly His Lys Val Glu Arg Pro Cys Leu Gln Arg Gln Asp Asp Ile 
        35                  40                  45              


Ala Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ala 
    50                  55                  60                  


Ile Val Ser Leu Ala Arg Ser His Val Ala Ser Glu Cys Asn Asn Glu 
65                  70                  75                  80  


Gln Phe Pro Leu Glu Met Pro Ile Tyr Thr Phe Gln Leu Pro Asp Leu 
                85                  90                  95      


Ser Val Tyr Ser Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
            100                 105                 110         


Glu Gln Ala Thr Met Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
        115                 120                 125             


Trp Ser Thr Val Cys Thr Ser Cys Lys Arg Leu Leu Pro Leu Ala Thr 
    130                 135                 140                 


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
145                 150                 155                 160 


Gly Phe His Asp Arg Asp Leu Val Leu Arg Lys Ala Leu Tyr Thr Met 
                165                 170                 175     


Met Arg Thr Gly Ala Glu Arg Glu Ala Leu Lys Arg Arg Trp Arg Trp 
            180                 185                 190         


Gln Gln Thr Gln Gln Asn Lys Glu Glu Glu Trp Glu Arg Glu Trp Thr 
        195                 200                 205             


Glu Leu Leu Lys Leu Ala Ser Ser Glu Pro Arg Thr His Phe Ser Lys 
    210                 215                 220                 


Asn Gly Gly Thr Gly Gly Gly Val Asp Asn Ser Glu Asp Pro Val Tyr 
225                 230                 235                 240 


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Ile Leu Arg 
                245                 250                 255     


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
            260                 265                 270         


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
        275                 280                 285             


Val Pro Pro Asn Arg Cys His Cys Ser Pro Leu Val Leu Ala Tyr Asp 
    290                 295                 300                 


Gln Ala His Phe Ser Ala Leu 
305                 310     


<210> 187
<211> 154
<212> PRT
<213> Homo sapiens

<400> 187
Met Glu Ala Ala Val Gly Val Pro Asp Gly Gly Asp Gln Gly Gly Ala 
1               5                   10                  15      


Gly Pro Arg Glu Asp Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            20                  25                  30          


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        35                  40                  45              


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    50                  55                  60                  


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
65                  70                  75                  80  


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                85                  90                  95      


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            100                 105                 110         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        115                 120                 125             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    130                 135                 140                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro 
145                 150                 


<210> 188
<211> 188
<212> PRT
<213> Homo sapiens

<400> 188
Met Ser Arg Lys Gln Ala Ala Lys Ser Arg Pro Gly Ser Gly Ser Arg 
1               5                   10                  15      


Lys Ala Glu Ala Glu Arg Lys Arg Asp Glu Arg Ala Ala Arg Arg Ala 
            20                  25                  30          


Leu Ala Lys Glu Arg Arg Asn Arg Pro Glu Ser Gly Gly Gly Gly Gly 
        35                  40                  45              


Cys Glu Glu Glu Phe Val Ser Phe Ala Asn Gln Leu Gln Ala Leu Gly 
    50                  55                  60                  


Leu Lys Leu Arg Glu Val Pro Gly Asp Gly Asn Cys Leu Phe Arg Ala 
65                  70                  75                  80  


Leu Gly Asp Gln Leu Glu Gly His Ser Arg Asn His Leu Lys His Arg 
                85                  90                  95      


Gln Glu Thr Val Asp Tyr Met Ile Lys Gln Arg Glu Asp Phe Glu Pro 
            100                 105                 110         


Phe Val Glu Asp Asp Ile Pro Phe Glu Lys His Val Ala Ser Leu Ala 
        115                 120                 125             


Lys Pro Gly Thr Phe Ala Gly Asn Asp Ala Ile Val Ala Phe Ala Arg 
    130                 135                 140                 


Asn His Gln Leu Asn Val Val Ile His Gln Leu Asn Ala Pro Leu Trp 
145                 150                 155                 160 


Gln Ile Arg Gly Thr Glu Lys Ser Ser Val Arg Glu Leu His Ile Ala 
                165                 170                 175     


Tyr Arg Tyr Gly Glu His Tyr Asp Ser Val Arg Arg 
            180                 185             


<210> 189
<211> 362
<212> PRT
<213> Homo sapiens

<400> 189
Met Thr Leu Asp Met Asp Ala Val Leu Ser Asp Phe Val Arg Ser Thr 
1               5                   10                  15      


Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu Leu Glu Gly Lys Asn Trp 
            20                  25                  30          


Asp Val Asn Ala Ala Leu Ser Asp Phe Glu Gln Leu Arg Gln Val His 
        35                  40                  45              


Ala Gly Asn Leu Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
    50                  55                  60                  


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
65                  70                  75                  80  


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
                85                  90                  95      


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
            100                 105                 110         


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
        115                 120                 125             


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
    130                 135                 140                 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
145                 150                 155                 160 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
                165                 170                 175     


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
            180                 185                 190         


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
        195                 200                 205             


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
    210                 215                 220                 


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
225                 230                 235                 240 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
                245                 250                 255     


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
            260                 265                 270         


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
        275                 280                 285             


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
    290                 295                 300                 


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
305                 310                 315                 320 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
                325                 330                 335     


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
            340                 345                 350         


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu 
        355                 360         


<210> 190
<211> 338
<212> PRT
<213> Homo sapiens

<400> 190
Met Thr Ile Leu Pro Lys Lys Lys Pro Pro Pro Pro Asp Ala Asp Pro 
1               5                   10                  15      


Ala Asn Glu Pro Pro Pro Pro Gly Pro Met Pro Pro Ala Pro Arg Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Val Gly Gly Gly Gly Thr Gly Val Gly Gly Gly 
        35                  40                  45              


Asp Arg Asp Arg Asp Ser Gly Val Val Gly Ala Arg Pro Arg Ala Ser 
    50                  55                  60                  


Pro Pro Pro Gln Gly Pro Leu Pro Gly Pro Pro Gly Ala Leu His Arg 
65                  70                  75                  80  


Trp Ala Leu Ala Val Pro Pro Gly Ala Val Ala Gly Pro Arg Pro Gln 
                85                  90                  95      


Gln Ala Ser Pro Pro Pro Cys Gly Gly Pro Gly Gly Pro Gly Gly Gly 
            100                 105                 110         


Pro Gly Asp Ala Leu Gly Ala Ala Ala Ala Gly Val Gly Ala Ala Gly 
        115                 120                 125             


Val Val Val Gly Val Gly Gly Ala Val Gly Val Gly Gly Cys Cys Ser 
    130                 135                 140                 


Gly Pro Gly His Ser Lys Arg Arg Arg Gln Ala Pro Gly Val Gly Ala 
145                 150                 155                 160 


Val Gly Gly Gly Ser Pro Glu Arg Glu Glu Val Gly Ala Gly Tyr Asn 
                165                 170                 175     


Ser Glu Asp Glu Tyr Glu Ala Ala Ala Ala Arg Ile Glu Ala Met Asp 
            180                 185                 190         


Pro Ala Thr Val Glu Gln Gln Glu His Trp Phe Glu Lys Ala Leu Arg 
        195                 200                 205             


Asp Lys Lys Gly Phe Ile Ile Lys Gln Met Lys Glu Asp Gly Ala Cys 
    210                 215                 220                 


Leu Phe Arg Ala Val Ala Asp Gln Val Tyr Gly Asp Gln Asp Met His 
225                 230                 235                 240 


Glu Val Val Arg Lys His Cys Met Asp Tyr Leu Met Lys Asn Ala Asp 
                245                 250                 255     


Tyr Phe Ser Asn Tyr Val Thr Glu Asp Phe Thr Thr Tyr Ile Asn Arg 
            260                 265                 270         


Lys Arg Lys Asn Asn Cys His Gly Asn His Ile Glu Met Gln Ala Met 
        275                 280                 285             


Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr Gln Tyr Ser Thr Gly 
    290                 295                 300                 


Thr Ser Ala Val Glu Pro Ile Asn Thr Phe His Gly Ile His Gln Asn 
305                 310                 315                 320 


Glu Asp Glu Pro Ile Arg Val Ser Tyr His Arg Asn Ile His Tyr Asn 
                325                 330                 335     


Ser Val 
        


<210> 191
<211> 260
<212> PRT
<213> Homo sapiens

<400> 191
Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu 
            260 


<210> 192
<211> 589
<212> PRT
<213> Homo sapiens

<400> 192
Met Ser Glu Arg Gly Ile Lys Trp Ala Cys Glu Tyr Cys Thr Tyr Glu 
1               5                   10                  15      


Asn Trp Pro Ser Ala Ile Lys Cys Thr Met Cys Arg Ala Gln Arg Pro 
            20                  25                  30          


Ser Gly Thr Ile Ile Thr Glu Asp Pro Phe Lys Ser Gly Ser Ser Asp 
        35                  40                  45              


Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly Ser Ser Pro 
    50                  55                  60                  


Leu Ile Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys Ser Ser Tyr 
65                  70                  75                  80  


Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys Thr Tyr Leu 
                85                  90                  95      


Asn Trp Pro Arg Ala Ile Arg Cys Thr Gln Cys Leu Ser Gln Arg Arg 
            100                 105                 110         


Thr Arg Ser Pro Thr Glu Ser Pro Gln Ser Ser Gly Ser Gly Ser Arg 
        115                 120                 125             


Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn Asp Arg Asn 
    130                 135                 140                 


Lys Leu Asn Thr Arg Thr Gln His Trp Thr Cys Ser Val Cys Thr Tyr 
145                 150                 155                 160 


Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp His Pro Arg 
                165                 170                 175     


Pro Asn Asn Ile Glu Ala Ile Glu Leu Ala Glu Thr Glu Glu Ala Ser 
            180                 185                 190         


Ser Ile Ile Asn Glu Gln Asp Arg Ala Arg Trp Arg Gly Ser Cys Ser 
        195                 200                 205             


Ser Gly Asn Ser Gln Arg Arg Ser Pro Pro Ala Thr Lys Arg Asp Ser 
    210                 215                 220                 


Glu Val Lys Met Asp Phe Gln Arg Ile Glu Leu Ala Gly Ala Val Gly 
225                 230                 235                 240 


Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
                245                 250                 255     


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
            260                 265                 270         


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
        275                 280                 285             


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
    290                 295                 300                 


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
305                 310                 315                 320 


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
                325                 330                 335     


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
            340                 345                 350         


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
        355                 360                 365             


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
    370                 375                 380                 


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
385                 390                 395                 400 


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
                405                 410                 415     


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
            420                 425                 430         


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
        435                 440                 445             


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
    450                 455                 460                 


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
465                 470                 475                 480 


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
                485                 490                 495     


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
            500                 505                 510         


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
        515                 520                 525             


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
    530                 535                 540                 


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
545                 550                 555                 560 


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
                565                 570                 575     


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu 
            580                 585                 


<210> 193
<211> 298
<212> PRT
<213> Homo sapiens

<400> 193
Pro Ala Ser Gly Ser Val Ser Ile Glu Cys Thr Glu Cys Gly Gln Arg 
1               5                   10                  15      


His Glu Gln Gln Gln Leu Leu Gly Val Glu Glu Val Thr Asp Pro Asp 
            20                  25                  30          


Val Val Leu His Asn Leu Leu Arg Asn Ala Leu Leu Gly Val Thr Gly 
        35                  40                  45              


Ala Pro Lys Lys Asn Thr Glu Leu Val Lys Val Met Gly Leu Ser Asn 
    50                  55                  60                  


Tyr His Cys Lys Leu Leu Ser Pro Ile Leu Ala Arg Tyr Gly Met Asp 
65                  70                  75                  80  


Lys Gln Thr Gly Arg Ala Lys Leu Leu Arg Asp Met Asn Gln Gly Glu 
                85                  90                  95      


Leu Phe Asp Cys Ala Leu Leu Gly Asp Arg Ala Phe Leu Ile Glu Pro 
            100                 105                 110         


Glu His Val Asn Thr Val Gly Tyr Gly Lys Asp Arg Ser Gly Ser Leu 
        115                 120                 125             


Leu Tyr Leu His Asp Thr Leu Glu Asp Ile Lys Arg Ala Asn Lys Ser 
    130                 135                 140                 


Gln Glu Cys Leu Ile Pro Val His Val Asp Gly Asp Gly His Cys Leu 
145                 150                 155                 160 


Val His Ala Val Ser Arg Ala Leu Val Gly Arg Glu Leu Phe Trp His 
                165                 170                 175     


Ala Leu Arg Glu Asn Leu Lys Gln His Phe Gln Gln His Leu Ala Arg 
            180                 185                 190         


Tyr Gln Ala Leu Phe His Asp Phe Ile Asp Ala Ala Glu Trp Glu Asp 
        195                 200                 205             


Ile Ile Asn Glu Cys Asp Pro Leu Phe Val Pro Pro Glu Gly Val Pro 
    210                 215                 220                 


Leu Gly Leu Arg Asn Ile His Ile Phe Gly Leu Ala Asn Val Leu His 
225                 230                 235                 240 


Arg Pro Ile Ile Leu Leu Asp Ser Leu Ser Gly Met Arg Ser Ser Gly 
                245                 250                 255     


Asp Tyr Ser Ala Thr Phe Leu Pro Gly Leu Ile Pro Ala Glu Lys Cys 
            260                 265                 270         


Thr Gly Lys Asp Gly His Leu Asn Lys Pro Ile Cys Ile Ala Trp Ser 
        275                 280                 285             


Ser Ser Gly Arg Asn His Tyr Ile Pro Leu 
    290                 295             


<210> 194
<211> 227
<212> PRT
<213> Homo sapiens

<400> 194
Gln Arg Trp Leu Pro Leu Glu Ala Asn Pro Glu Val Thr Asn Gln Phe 
1               5                   10                  15      


Leu Lys Gln Leu Gly Leu His Pro Asn Trp Gln Phe Val Asp Val Tyr 
            20                  25                  30          


Gly Met Asp Pro Glu Leu Leu Ser Met Val Pro Arg Pro Val Cys Ala 
        35                  40                  45              


Val Leu Leu Leu Phe Pro Ile Thr Glu Lys Tyr Glu Val Phe Arg Thr 
    50                  55                  60                  


Glu Glu Glu Glu Lys Ile Lys Ser Gln Gly Gln Asp Val Thr Ser Ser 
65                  70                  75                  80  


Val Tyr Phe Met Lys Gln Thr Ile Ser Asn Ala Cys Gly Thr Ile Gly 
                85                  90                  95      


Leu Ile His Ala Ile Ala Asn Asn Lys Asp Lys Met His Phe Glu Ser 
            100                 105                 110         


Gly Ser Thr Leu Lys Lys Phe Leu Glu Glu Ser Val Ser Met Ser Pro 
        115                 120                 125             


Glu Glu Arg Ala Arg Tyr Leu Glu Asn Tyr Asp Ala Ile Arg Val Thr 
    130                 135                 140                 


His Glu Thr Ser Ala His Glu Gly Gln Thr Glu Ala Pro Ser Ile Asp 
145                 150                 155                 160 


Glu Lys Val Asp Leu His Phe Ile Ala Leu Val His Val Asp Gly His 
                165                 170                 175     


Leu Tyr Glu Leu Asp Gly Arg Lys Pro Phe Pro Ile Asn His Gly Glu 
            180                 185                 190         


Thr Ser Asp Glu Thr Leu Leu Glu Asp Ala Ile Glu Val Cys Lys Lys 
        195                 200                 205             


Phe Met Glu Arg Asp Pro Asp Glu Leu Arg Phe Asn Ala Ile Ala Leu 
    210                 215                 220                 


Ser Ala Ala 
225         


<210> 195
<211> 223
<212> PRT
<213> Homo sapiens

<400> 195
Gly Glu Trp Cys Leu Met Glu Ser Asp Pro Gly Val Phe Thr Glu Leu 
1               5                   10                  15      


Ile Lys Gly Phe Gly Cys Arg Gly Ala Gln Val Glu Glu Ile Trp Ser 
            20                  25                  30          


Leu Glu Pro Glu Asn Phe Glu Lys Leu Lys Pro Val His Gly Leu Ile 
        35                  40                  45              


Phe Leu Phe Lys Trp Gln Pro Gly Glu Glu Pro Ala Gly Ser Val Val 
    50                  55                  60                  


Gln Asp Ser Arg Leu Asp Thr Ile Phe Phe Ala Lys Gln Val Ile Asn 
65                  70                  75                  80  


Asn Ala Cys Ala Thr Gln Ala Ile Val Ser Val Leu Leu Asn Cys Thr 
                85                  90                  95      


His Gln Asp Val His Leu Gly Glu Thr Leu Ser Glu Phe Lys Glu Phe 
            100                 105                 110         


Ser Gln Ser Phe Asp Ala Ala Met Lys Gly Leu Ala Leu Ser Asn Ser 
        115                 120                 125             


Asp Val Ile Arg Gln Val His Asn Ser Phe Ala Arg Gln Gln Met Phe 
    130                 135                 140                 


Glu Phe Asp Thr Lys Thr Ser Ala Lys Glu Glu Asp Ala Phe His Phe 
145                 150                 155                 160 


Val Ser Tyr Val Pro Val Asn Gly Arg Leu Tyr Glu Leu Asp Gly Leu 
                165                 170                 175     


Arg Glu Gly Pro Ile Asp Leu Gly Ala Cys Asn Gln Asp Asp Trp Ile 
            180                 185                 190         


Ser Ala Val Arg Pro Val Ile Glu Lys Arg Ile Gln Lys Tyr Ser Glu 
        195                 200                 205             


Gly Glu Ile Arg Phe Asn Leu Met Ala Ile Val Ser Asp Arg Lys 
    210                 215                 220             


<210> 196
<211> 165
<212> PRT
<213> Homo sapiens

<400> 196
Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln His 
1               5                   10                  15      


Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu Leu 
            20                  25                  30          


Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met Ala 
        35                  40                  45              


Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Gln Pro 
    50                  55                  60                  


Ser Gly Asn Met Asp Asp Ser Gly Phe Phe Ser Ile Gln Val Ile Ser 
65                  70                  75                  80  


Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn Ser Pro 
                85                  90                  95      


Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser Phe Ile 
            100                 105                 110         


Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly Lys Gln 
        115                 120                 125             


Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile Ser Asp 
    130                 135                 140                 


Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly Tyr Ser 
145                 150                 155                 160 


Ile Phe Val Val Lys 
                165 


<210> 197
<211> 163
<212> PRT
<213> Homo sapiens

<400> 197
Pro Thr Val Tyr His Glu Arg Gln Arg Leu Glu Leu Cys Ala Val His 
1               5                   10                  15      


Ala Leu Asn Asn Val Leu Gln Gln Gln Leu Phe Ser Gln Glu Ala Ala 
            20                  25                  30          


Asp Glu Ile Cys Lys Arg Leu Ala Pro Asp Ser Arg Leu Asn Pro His 
        35                  40                  45              


Arg Ser Leu Leu Gly Thr Gly Asn Tyr Asp Val Asn Val Ile Met Ala 
    50                  55                  60                  


Ala Leu Gln Gly Leu Gly Leu Ala Ala Val Trp Trp Asp Arg Arg Arg 
65                  70                  75                  80  


Pro Leu Ser Gln Leu Ala Leu Pro Gln Val Leu Gly Leu Ile Leu Asn 
                85                  90                  95      


Leu Pro Ser Pro Val Ser Leu Gly Leu Leu Ser Leu Pro Leu Arg Arg 
            100                 105                 110         


Arg His Trp Val Ala Leu Arg Gln Val Asp Gly Val Tyr Tyr Asn Leu 
        115                 120                 125             


Asp Ser Lys Leu Arg Ala Pro Glu Ala Leu Gly Asp Glu Asp Gly Val 
    130                 135                 140                 


Arg Ala Phe Leu Ala Ala Ala Leu Ala Gln Gly Leu Cys Glu Val Leu 
145                 150                 155                 160 


Leu Val Val 
            


<210> 198
<211> 170
<212> PRT
<213> Homo sapiens

<400> 198
Pro Gln Ala Ala Pro Pro Gln Ile Tyr His Glu Lys Gln Arg Arg Glu 
1               5                   10                  15      


Leu Cys Ala Leu His Ala Leu Asn Asn Val Phe Gln Asp Ser Asn Ala 
            20                  25                  30          


Phe Thr Arg Asp Thr Leu Gln Glu Ile Phe Gln Arg Leu Ser Pro Asn 
        35                  40                  45              


Thr Met Val Thr Pro His Lys Lys Ser Met Leu Gly Asn Gly Asn Tyr 
    50                  55                  60                  


Asp Val Asn Val Ile Met Ala Ala Leu Gln Thr Lys Gly Tyr Glu Ala 
65                  70                  75                  80  


Val Trp Trp Asp Lys Arg Arg Asp Val Gly Val Ile Ala Leu Thr Asn 
                85                  90                  95      


Val Met Gly Phe Ile Met Asn Leu Pro Ser Ser Leu Cys Trp Gly Pro 
            100                 105                 110         


Leu Lys Leu Pro Leu Lys Arg Gln His Trp Ile Cys Val Arg Glu Val 
        115                 120                 125             


Gly Gly Ala Tyr Tyr Asn Leu Asp Ser Lys Leu Lys Met Pro Glu Trp 
    130                 135                 140                 


Ile Gly Gly Glu Ser Glu Leu Arg Lys Phe Leu Lys His His Leu Arg 
145                 150                 155                 160 


Gly Lys Asn Cys Glu Leu Leu Leu Val Val 
                165                 170 


<210> 199
<211> 165
<212> PRT
<213> Homo sapiens

<400> 199
Asp Phe Ile Phe His Glu Lys Gln Glu Gly Phe Leu Cys Ala Gln His 
1               5                   10                  15      


Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu Leu 
            20                  25                  30          


Ala Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met Ala 
        35                  40                  45              


Glu Gly Gly Val Thr Ser Glu Glu Tyr Leu Ala Phe Leu Gln Gln Pro 
    50                  55                  60                  


Ser Glu Asn Met Asp Asp Thr Gly Phe Phe Ser Ile Gln Val Ile Ser 
65                  70                  75                  80  


Asn Ala Leu Lys Phe Trp Gly Leu Glu Ile Ile His Phe Asn Asn Pro 
                85                  90                  95      


Glu Tyr Gln Lys Leu Gly Ile Asp Pro Ile Asn Glu Arg Ser Phe Ile 
            100                 105                 110         


Cys Asn Tyr Lys Gln His Trp Phe Thr Ile Arg Lys Phe Gly Lys His 
        115                 120                 125             


Trp Phe Asn Leu Asn Ser Leu Leu Ala Gly Pro Glu Leu Ile Ser Asp 
    130                 135                 140                 


Thr Cys Leu Ala Asn Phe Leu Ala Arg Leu Gln Gln Gln Ala Tyr Ser 
145                 150                 155                 160 


Val Phe Val Val Lys 
                165 


<210> 200
<211> 419
<212> PRT
<213> Homo sapiens

<400> 200
Cys Arg Trp Thr Gln Gly Phe Val Phe Ser Glu Ser Glu Gly Ser Ala 
1               5                   10                  15      


Leu Glu Gln Phe Glu Gly Gly Pro Cys Ala Val Ile Ala Pro Val Gln 
            20                  25                  30          


Ala Phe Leu Leu Lys Lys Leu Leu Phe Ser Ser Glu Lys Ser Ser Trp 
        35                  40                  45              


Arg Asp Cys Ser Glu Glu Glu Gln Lys Glu Leu Leu Cys His Thr Leu 
    50                  55                  60                  


Cys Asp Ile Leu Glu Ser Ala Cys Cys Asp His Ser Gly Ser Tyr Cys 
65                  70                  75                  80  


Leu Val Ser Trp Leu Arg Gly Lys Thr Thr Glu Glu Thr Ala Ser Ile 
                85                  90                  95      


Ser Gly Ser Pro Ala Glu Ser Ser Cys Gln Val Glu His Ser Ser Ala 
            100                 105                 110         


Leu Ala Val Glu Glu Leu Gly Phe Glu Arg Phe His Ala Leu Ile Gln 
        115                 120                 125             


Lys Arg Ser Phe Arg Ser Leu Pro Glu Leu Lys Asp Ala Val Leu Asp 
    130                 135                 140                 


Gln Tyr Ser Met Trp Gly Asn Lys Phe Gly Val Leu Leu Phe Leu Tyr 
145                 150                 155                 160 


Ser Val Leu Leu Thr Lys Gly Ile Glu Asn Ile Lys Asn Glu Ile Glu 
                165                 170                 175     


Asp Ala Ser Glu Pro Leu Ile Asp Pro Val Tyr Gly His Gly Ser Gln 
            180                 185                 190         


Ser Leu Ile Asn Leu Leu Leu Thr Gly His Ala Val Ser Asn Val Trp 
        195                 200                 205             


Asp Gly Asp Arg Glu Cys Ser Gly Met Lys Leu Leu Gly Ile His Glu 
    210                 215                 220                 


Gln Ala Ala Val Gly Phe Leu Thr Leu Met Glu Ala Leu Arg Tyr Cys 
225                 230                 235                 240 


Lys Val Gly Ser Tyr Leu Lys Ser Pro Lys Phe Pro Ile Trp Ile Val 
                245                 250                 255     


Gly Ser Glu Thr His Leu Thr Val Phe Phe Ala Lys Asp Met Ala Leu 
            260                 265                 270         


Val Ala Pro Glu Ala Pro Ser Glu Gln Ala Arg Arg Val Phe Gln Thr 
        275                 280                 285             


Tyr Asp Pro Glu Asp Asn Gly Phe Ile Pro Asp Ser Leu Leu Glu Asp 
    290                 295                 300                 


Val Met Lys Ala Leu Asp Leu Val Ser Asp Pro Glu Tyr Ile Asn Leu 
305                 310                 315                 320 


Met Lys Asn Lys Leu Asp Pro Glu Gly Leu Gly Ile Ile Leu Leu Gly 
                325                 330                 335     


Pro Phe Leu Gln Glu Phe Phe Pro Asp Gln Gly Ser Ser Gly Pro Glu 
            340                 345                 350         


Ser Phe Thr Val Tyr His Tyr Asn Gly Leu Lys Gln Ser Asn Tyr Asn 
        355                 360                 365             


Glu Lys Val Met Tyr Val Glu Gly Thr Ala Val Val Met Gly Phe Glu 
    370                 375                 380                 


Asp Pro Met Leu Gln Thr Asp Asp Thr Pro Ile Lys Arg Cys Leu Gln 
385                 390                 395                 400 


Thr Lys Trp Pro Tyr Ile Glu Leu Leu Trp Thr Thr Asp Arg Ser Pro 
                405                 410                 415     


Ser Leu Asn 
            


<210> 201
<211> 356
<212> PRT
<213> Homo sapiens

<400> 201
Tyr Cys Val Lys Trp Ile Pro Trp Lys Gly Glu Gln Thr Pro Ile Ile 
1               5                   10                  15      


Thr Gln Ser Thr Asn Gly Pro Cys Pro Leu Leu Ala Ile Met Asn Ile 
            20                  25                  30          


Leu Phe Leu Gln Trp Lys Val Lys Leu Pro Pro Gln Lys Glu Val Ile 
        35                  40                  45              


Thr Ser Asp Glu Leu Met Ala His Leu Gly Asn Cys Leu Leu Ser Ile 
    50                  55                  60                  


Lys Pro Gln Glu Lys Ser Glu Gly Leu Gln Leu Asn Phe Gln Gln Asn 
65                  70                  75                  80  


Val Asp Asp Ala Met Thr Val Leu Pro Lys Leu Ala Thr Gly Leu Asp 
                85                  90                  95      


Val Asn Val Arg Phe Thr Gly Val Ser Asp Phe Glu Tyr Thr Pro Glu 
            100                 105                 110         


Cys Ser Val Phe Asp Leu Leu Gly Ile Pro Leu Tyr His Gly Trp Leu 
        115                 120                 125             


Val Asp Pro Gln Ser Pro Glu Ala Val Arg Ala Val Gly Lys Leu Ser 
    130                 135                 140                 


Tyr Asn Gln Leu Val Glu Arg Ile Ile Thr Cys Lys His Ser Ser Asp 
145                 150                 155                 160 


Thr Asn Leu Val Thr Glu Gly Leu Ile Ala Glu Gln Phe Leu Glu Thr 
                165                 170                 175     


Thr Ala Ala Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ala Ala 
            180                 185                 190         


Ala Lys Glu Gly Glu Leu Ser Val Phe Phe Arg Asn Asn His Phe Ser 
        195                 200                 205             


Thr Met Thr Lys His Lys Ser His Leu Tyr Leu Leu Val Thr Asp Gln 
    210                 215                 220                 


Gly Phe Leu Gln Glu Glu Gln Val Val Trp Glu Ser Leu His Asn Val 
225                 230                 235                 240 


Asp Gly Asp Ser Cys Phe Cys Asp Ser Asp Phe His Leu Ser His Ser 
                245                 250                 255     


Leu Gly Lys Gly Pro Gly Ala Glu Gly Gly Ser Gly Ser Pro Glu Thr 
            260                 265                 270         


Gln Leu Gln Val Asp Gln Asp Tyr Leu Ile Ala Leu Ser Leu Gln Gln 
        275                 280                 285             


Gln Gln Pro Arg Gly Pro Leu Gly Leu Thr Asp Leu Glu Leu Ala Gln 
    290                 295                 300                 


Gln Leu Gln Gln Glu Glu Tyr Gln Gln Gln Gln Ala Ala Gln Pro Val 
305                 310                 315                 320 


Arg Met Arg Thr Arg Val Leu Ser Leu Gln Gly Arg Gly Ala Thr Ser 
                325                 330                 335     


Gly Arg Pro Ala Gly Glu Arg Arg Gln Arg Pro Lys His Glu Ser Asp 
            340                 345                 350         


Cys Ile Leu Leu 
        355     


<210> 202
<211> 379
<212> PRT
<213> Homo sapiens

<400> 202
Tyr His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro Ile Ile 
1               5                   10                  15      


Thr Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu Asn Val 
            20                  25                  30          


Leu Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu Ile Ile 
        35                  40                  45              


Thr Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu Asp Ala 
    50                  55                  60                  


Lys Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu Gln Asn 
65                  70                  75                  80  


Met Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly Leu Asp 
                85                  90                  95      


Val Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr Pro Glu 
            100                 105                 110         


Cys Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly Trp Leu 
        115                 120                 125             


Val Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn Cys Ser 
    130                 135                 140                 


Tyr Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser Asp Asn 
145                 150                 155                 160 


Ser Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu Asn Asn 
                165                 170                 175     


Thr Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ser Thr 
            180                 185                 190         


Val Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His Phe Ser 
        195                 200                 205             


Thr Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr Asp Gln 
    210                 215                 220                 


Gly Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His Asn Val 
225                 230                 235                 240 


Asp Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg Pro Pro 
                245                 250                 255     


Ser Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile Asp Gln 
            260                 265                 270         


Asp Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser Gln Glu 
        275                 280                 285             


Ile Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu Leu Ala 
    290                 295                 300                 


Lys Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr Tyr Gln 
305                 310                 315                 320 


Glu Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr Gln Ala 
                325                 330                 335     


Gln Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg Gln Ser 
            340                 345                 350         


Gly Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp Lys Glu 
        355                 360                 365             


Lys Glu Lys Glu Lys Asn Ser Cys Val Ile Leu 
    370                 375                 


<210> 203
<211> 334
<212> PRT
<213> Homo sapiens

<400> 203
Phe Cys Cys Phe Asn Glu Glu Trp Lys Leu Gln Ser Phe Ser Phe Ser 
1               5                   10                  15      


Asn Thr Ala Ser Leu Lys Tyr Gly Ile Val Gln Asn Lys Gly Gly Pro 
            20                  25                  30          


Cys Gly Val Leu Ala Ala Val Gln Gly Cys Val Leu Gln Lys Leu Leu 
        35                  40                  45              


Phe Glu Gly Asp Ser Lys Ala Asp Cys Ala Gln Gly Leu Gln Pro Ser 
    50                  55                  60                  


Asp Ala His Arg Thr Arg Cys Leu Val Leu Ala Leu Ala Asp Ile Val 
65                  70                  75                  80  


Trp Arg Ala Gly Gly Arg Glu Arg Ala Val Val Ala Leu Ala Ser Arg 
                85                  90                  95      


Thr Gln Gln Phe Ser Pro Thr Gly Lys Tyr Lys Ala Asp Gly Val Leu 
            100                 105                 110         


Glu Thr Leu Thr Leu His Ser Leu Thr Cys Tyr Glu Asp Leu Val Thr 
        115                 120                 125             


Phe Leu Gln Gln Ser Ile His Gln Phe Glu Val Gly Pro Tyr Gly Cys 
    130                 135                 140                 


Ile Leu Leu Thr Leu Ser Ala Ile Leu Ser Arg Ser Thr Glu Leu Ile 
145                 150                 155                 160 


Arg Gln Asp Phe Asp Val Pro Thr Ser His Leu Ile Gly Ala His Gly 
                165                 170                 175     


Tyr Cys Thr Gln Glu Leu Val Asn Leu Leu Leu Thr Gly Lys Ala Val 
            180                 185                 190         


Ser Asn Val Phe Asn Asp Val Val Glu Leu Asp Ser Gly Asp Gly Asn 
        195                 200                 205             


Ile Thr Leu Leu Arg Gly Ile Ala Ala Arg Ser Asp Ile Gly Phe Leu 
    210                 215                 220                 


Ser Leu Phe Glu His Tyr Asn Met Cys Gln Val Gly Cys Phe Leu Lys 
225                 230                 235                 240 


Thr Pro Arg Phe Pro Ile Trp Val Val Cys Ser Glu Ser His Phe Ser 
                245                 250                 255     


Ile Leu Phe Ser Leu Gln Pro Gly Leu Leu Arg Asp Trp Arg Thr Glu 
            260                 265                 270         


Arg Leu Phe Asp Leu Tyr Tyr Tyr Asp Gly Leu Ala Asn Gln Gln Glu 
        275                 280                 285             


Gln Ile Arg Leu Thr Ile Asp Thr Thr Gln Thr Ile Ser Glu Asp Thr 
    290                 295                 300                 


Asp Asn Asp Leu Val Pro Pro Leu Glu Leu Cys Ile Arg Thr Lys Trp 
305                 310                 315                 320 


Lys Gly Ala Ser Val Asn Trp Asn Gly Ser Asp Pro Ile Leu 
                325                 330                 


<210> 204
<211> 167
<212> PRT
<213> Homo sapiens

<400> 204
Val Val Pro Gly Arg Leu Cys Pro Gln Phe Leu Gln Leu Ala Ser Ala 
1               5                   10                  15      


Asn Thr Ala Arg Gly Val Glu Thr Cys Gly Ile Leu Cys Gly Lys Leu 
            20                  25                  30          


Met Arg Asn Glu Phe Thr Ile Thr His Val Leu Ile Pro Lys Gln Ser 
        35                  40                  45              


Ala Gly Ser Asp Tyr Cys Asn Thr Glu Asn Glu Glu Glu Leu Phe Leu 
    50                  55                  60                  


Ile Gln Asp Gln Gln Gly Leu Ile Thr Leu Gly Trp Ile His Thr His 
65                  70                  75                  80  


Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His Cys 
                85                  90                  95      


Ser Tyr Gln Met Met Leu Pro Glu Ser Val Ala Ile Val Cys Ser Pro 
            100                 105                 110         


Lys Phe Gln Glu Thr Gly Phe Phe Lys Leu Thr Asp His Gly Leu Glu 
        115                 120                 125             


Glu Ile Ser Ser Cys Arg Gln Lys Gly Phe His Pro His Ser Lys Asp 
    130                 135                 140                 


Pro Pro Leu Phe Cys Ser Cys Ser His Val Thr Val Val Asp Arg Ala 
145                 150                 155                 160 


Val Thr Ile Thr Asp Leu Arg 
                165         


<210> 205
<211> 200
<212> PRT
<213> Homo sapiens

<400> 205
Val Ala Val Ser Ser Asn Val Leu Phe Leu Leu Asp Phe His Ser His 
1               5                   10                  15      


Leu Thr Arg Ser Glu Val Val Gly Tyr Leu Gly Gly Arg Trp Asp Val 
            20                  25                  30          


Asn Ser Gln Met Leu Thr Val Leu Arg Ala Phe Pro Cys Arg Ser Arg 
        35                  40                  45              


Leu Gly Asp Ala Glu Thr Ala Ala Ala Ile Glu Glu Glu Ile Tyr Gln 
    50                  55                  60                  


Ser Leu Phe Leu Arg Gly Leu Ser Leu Val Gly Trp Tyr His Ser His 
65                  70                  75                  80  


Pro His Ser Pro Ala Leu Pro Ser Leu Gln Asp Ile Asp Ala Gln Met 
                85                  90                  95      


Asp Tyr Gln Leu Arg Leu Gln Gly Ser Ser Asn Gly Phe Gln Pro Cys 
            100                 105                 110         


Leu Ala Leu Leu Cys Ser Pro Tyr Tyr Ser Gly Asn Pro Gly Pro Glu 
        115                 120                 125             


Ser Lys Ile Ser Pro Phe Trp Val Met Pro Pro Pro Glu Met Leu Leu 
    130                 135                 140                 


Val Glu Phe Tyr Lys Gly Ser Pro Asp Leu Val Arg Leu Gln Glu Pro 
145                 150                 155                 160 


Trp Ser Gln Glu His Thr Tyr Leu Asp Lys Leu Lys Ile Ser Leu Ala 
                165                 170                 175     


Ser Arg Thr Pro Lys Asp Gln Ser Leu Cys His Val Leu Glu Gln Val 
            180                 185                 190         


Cys Gly Val Leu Lys Gln Gly Ser 
        195                 200 


<210> 206
<211> 201
<212> PRT
<213> Homo sapiens

<400> 206
Ala Leu Ala Tyr Val Lys Met Cys Leu His Ala Ala Arg Tyr Pro His 
1               5                   10                  15      


Ala Ala Val Asn Gly Leu Phe Leu Ala Pro Ala Pro Arg Ser Gly Glu 
            20                  25                  30          


Cys Leu Cys Leu Thr Asp Cys Val Pro Leu Phe His Ser His Leu Ala 
        35                  40                  45              


Leu Ser Val Met Leu Glu Val Ala Leu Asn Gln Val Asp Val Trp Gly 
    50                  55                  60                  


Ala Gln Ala Gly Leu Val Val Ala Gly Tyr Tyr His Ala Asn Ala Ala 
65                  70                  75                  80  


Val Asn Asp Gln Ser Pro Gly Pro Leu Ala Leu Lys Ile Ala Gly Arg 
                85                  90                  95      


Ile Ala Glu Phe Phe Pro Asp Ala Val Leu Ile Met Leu Asp Asn Gln 
            100                 105                 110         


Lys Leu Val Pro Gln Pro Arg Val Pro Pro Val Ile Val Leu Glu Asn 
        115                 120                 125             


Gln Gly Leu Arg Trp Val Pro Lys Asp Lys Asn Leu Val Met Trp Arg 
    130                 135                 140                 


Asp Trp Glu Glu Ser Arg Gln Met Val Gly Ala Leu Leu Glu Asp Arg 
145                 150                 155                 160 


Ala His Gln His Leu Val Asp Phe Asp Cys His Leu Asp Asp Ile Arg 
                165                 170                 175     


Gln Asp Trp Thr Asn Gln Arg Leu Asn Thr Gln Ile Thr Gln Trp Val 
            180                 185                 190         


Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200     


<210> 207
<211> 281
<212> PRT
<213> Homo sapiens

<400> 207
Gln Val Tyr Ile Ser Ser Leu Ala Leu Leu Lys Met Leu Lys His Gly 
1               5                   10                  15      


Arg Ala Gly Val Pro Met Glu Val Met Gly Leu Met Leu Gly Glu Phe 
            20                  25                  30          


Val Asp Asp Tyr Thr Val Arg Val Ile Asp Val Phe Ala Met Pro Gln 
        35                  40                  45              


Ser Gly Thr Gly Val Ser Val Glu Ala Val Asp Pro Val Phe Gln Ala 
    50                  55                  60                  


Lys Met Leu Asp Met Leu Lys Gln Thr Gly Arg Pro Glu Met Val Val 
65                  70                  75                  80  


Gly Trp Tyr His Ser His Pro Gly Phe Gly Cys Trp Leu Ser Gly Val 
                85                  90                  95      


Asp Ile Asn Thr Gln Gln Ser Phe Glu Ala Leu Ser Glu Arg Ala Val 
            100                 105                 110         


Ala Val Val Val Asp Pro Ile Gln Ser Val Lys Gly Lys Val Val Ile 
        115                 120                 125             


Asp Ala Phe Arg Leu Ile Asn Ala Asn Met Met Val Leu Gly His Glu 
    130                 135                 140                 


Pro Arg Gln Thr Thr Ser Asn Leu Gly His Leu Asn Lys Pro Ser Ile 
145                 150                 155                 160 


Gln Ala Leu Ile His Gly Leu Asn Arg His Tyr Tyr Ser Ile Thr Ile 
                165                 170                 175     


Asn Tyr Arg Lys Asn Glu Leu Glu Gln Lys Met Leu Leu Asn Leu His 
            180                 185                 190         


Lys Lys Ser Trp Met Glu Gly Leu Thr Leu Gln Asp Tyr Ser Glu His 
        195                 200                 205             


Cys Lys His Asn Glu Ser Val Val Lys Glu Met Leu Glu Leu Ala Lys 
    210                 215                 220                 


Asn Tyr Asn Lys Ala Val Glu Glu Glu Asp Lys Met Thr Pro Glu Gln 
225                 230                 235                 240 


Leu Ala Ile Lys Asn Val Gly Lys Gln Asp Pro Lys Arg His Leu Glu 
                245                 250                 255     


Glu His Val Asp Val Leu Met Thr Ser Asn Ile Val Gln Cys Leu Ala 
            260                 265                 270         


Ala Met Leu Asp Thr Val Val Phe Lys 
        275                 280     


<210> 208
<211> 253
<212> PRT
<213> Homo sapiens

<400> 208
Gln Val Lys Val Ala Ser Glu Ala Leu Leu Ile Met Asp Leu His Ala 
1               5                   10                  15      


His Val Ser Met Ala Glu Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser 
            20                  25                  30          


Glu Val Asp Lys Val Val Glu Val Cys Ala Ala Glu Pro Cys Asn Ser 
        35                  40                  45              


Leu Ser Thr Gly Leu Gln Cys Glu Met Asp Pro Val Ser Gln Thr Gln 
    50                  55                  60                  


Ala Ser Glu Thr Leu Ala Val Arg Gly Phe Ser Val Ile Gly Trp Tyr 
65                  70                  75                  80  


His Ser His Pro Ala Phe Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp 
                85                  90                  95      


Thr Gln Ala Lys Tyr Gln Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe 
            100                 105                 110         


Ile Gly Met Ile Val Ser Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr 
        115                 120                 125             


Ser Gln Ile Thr Cys Leu Val Ile Ser Glu Glu Ile Ser Pro Asp Gly 
    130                 135                 140                 


Ser Tyr Arg Leu Pro Tyr Lys Phe Glu Val Gln Gln Met Leu Glu Glu 
145                 150                 155                 160 


Pro Gln Trp Gly Leu Val Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys 
                165                 170                 175     


Tyr Arg Leu Ser His Ser Ser Val Pro Met Asp Lys Ile Phe Arg Arg 
            180                 185                 190         


Asp Ser Asp Leu Thr Cys Leu Gln Lys Leu Leu Glu Cys Met Arg Lys 
        195                 200                 205             


Thr Leu Ser Lys Val Thr Asn Cys Phe Met Ala Glu Glu Phe Leu Thr 
    210                 215                 220                 


Glu Ile Glu Asn Leu Phe Leu Ser Asn Tyr Lys Ser Asn Gln Glu Asn 
225                 230                 235                 240 


Gly Val Thr Glu Glu Asn Cys Thr Lys Glu Leu Leu Met 
                245                 250             


<210> 209
<211> 404
<212> PRT
<213> Homo sapiens

<400> 209
Ala Val Cys Phe His Ser Ala Asn Ser Asn Ala Asp His Glu Gly Phe 
1               5                   10                  15      


Leu Leu Gly Glu Val Arg Gln Glu Glu Thr Phe Ser Ile Ser Asp Ser 
            20                  25                  30          


Gln Ile Ser Asn Thr Glu Phe Leu Gln Val Ile Glu Ile His Asn His 
        35                  40                  45              


Gln Pro Cys Ser Lys Leu Phe Ser Phe Tyr Asp Tyr Ala Ser Lys Val 
    50                  55                  60                  


Asn Glu Glu Ser Leu Asp Arg Ile Leu Lys Asp Arg Arg Lys Lys Val 
65                  70                  75                  80  


Ile Gly Trp Tyr Arg Phe Arg Arg Asn Thr Gln Gln Gln Met Ser Tyr 
                85                  90                  95      


Arg Glu Gln Val Leu His Lys Gln Leu Thr Arg Ile Leu Gly Val Pro 
            100                 105                 110         


Asp Leu Val Phe Leu Leu Phe Ser Phe Ile Ser Thr Ala Asn Asn Ser 
        115                 120                 125             


Thr His Ala Leu Glu Tyr Val Leu Phe Arg Pro Asn Arg Arg Tyr Asn 
    130                 135                 140                 


Gln Arg Ile Ser Leu Ala Ile Pro Asn Leu Gly Asn Thr Ser Gln Gln 
145                 150                 155                 160 


Glu Tyr Lys Val Ser Ser Val Pro Asn Thr Ser Gln Ser Tyr Ala Lys 
                165                 170                 175     


Val Ile Lys Glu His Gly Thr Asp Phe Phe Asp Lys Asp Gly Val Met 
            180                 185                 190         


Lys Asp Ile Arg Ala Ile Tyr Gln Val Tyr Asn Ala Leu Gln Glu Lys 
        195                 200                 205             


Val Gln Ala Val Cys Ala Asp Val Glu Lys Ser Glu Arg Val Val Glu 
    210                 215                 220                 


Ser Cys Gln Ala Glu Val Asn Lys Leu Arg Arg Gln Ile Thr Gln Arg 
225                 230                 235                 240 


Lys Asn Glu Lys Glu Gln Glu Arg Arg Leu Gln Gln Ala Val Leu Ser 
                245                 250                 255     


Arg Gln Met Pro Ser Glu Ser Leu Asp Pro Ala Phe Ser Pro Arg Met 
            260                 265                 270         


Pro Ser Ser Gly Phe Ala Ala Glu Gly Arg Ser Thr Leu Gly Asp Ala 
        275                 280                 285             


Glu Ala Ser Asp Pro Pro Pro Pro Tyr Ser Asp Phe His Pro Asn Asn 
    290                 295                 300                 


Gln Glu Ser Thr Leu Ser His Ser Arg Met Glu Arg Ser Val Phe Met 
305                 310                 315                 320 


Pro Arg Pro Gln Ala Val Gly Ser Ser Asn Tyr Ala Ser Thr Ser Ala 
                325                 330                 335     


Gly Leu Lys Tyr Pro Gly Ser Gly Ala Asp Leu Pro Pro Pro Gln Arg 
            340                 345                 350         


Ala Ala Gly Asp Ser Gly Glu Asp Ser Asp Asp Ser Asp Tyr Glu Asn 
        355                 360                 365             


Leu Ile Asp Pro Thr Glu Pro Ser Asn Ser Glu Tyr Ser His Ser Lys 
    370                 375                 380                 


Asp Ser Arg Pro Met Ala His Pro Asp Glu Asp Pro Arg Asn Thr Gln 
385                 390                 395                 400 


Thr Ser Gln Ile 
                


<210> 210
<211> 526
<212> PRT
<213> Homo sapiens

<400> 210
Phe Asn Pro Arg Thr Gly Gln Leu Phe Leu Lys Ile Ile His Thr Ser 
1               5                   10                  15      


Val Trp Ala Gly Gln Lys Arg Leu Gly Gln Leu Ala Lys Trp Lys Thr 
            20                  25                  30          


Ala Glu Glu Val Ala Ala Leu Ile Arg Ser Leu Pro Val Glu Glu Gln 
        35                  40                  45              


Pro Lys Gln Ile Ile Val Thr Arg Lys Gly Met Leu Asp Pro Leu Glu 
    50                  55                  60                  


Val His Leu Leu Asp Phe Pro Asn Ile Val Ile Lys Gly Ser Glu Leu 
65                  70                  75                  80  


Gln Leu Pro Phe Gln Ala Cys Leu Lys Val Glu Lys Phe Gly Asp Leu 
                85                  90                  95      


Ile Leu Lys Ala Thr Glu Pro Gln Met Val Leu Phe Asn Leu Tyr Asp 
            100                 105                 110         


Asp Trp Leu Lys Thr Ile Ser Ser Tyr Thr Ala Phe Ser Arg Leu Ile 
        115                 120                 125             


Leu Ile Leu Arg Ala Leu His Val Asn Asn Asp Arg Ala Lys Val Ile 
    130                 135                 140                 


Leu Lys Pro Asp Lys Thr Thr Ile Thr Glu Pro His His Ile Trp Pro 
145                 150                 155                 160 


Thr Leu Thr Asp Glu Glu Trp Ile Lys Val Glu Val Gln Leu Lys Asp 
                165                 170                 175     


Leu Ile Leu Ala Asp Tyr Gly Lys Lys Asn Asn Val Asn Val Ala Ser 
            180                 185                 190         


Leu Thr Gln Ser Glu Ile Arg Asp Ile Ile Leu Gly Met Glu Ile Ser 
        195                 200                 205             


Ala Pro Ser Gln Gln Arg Gln Gln Ile Ala Glu Ile Glu Lys Gln Thr 
    210                 215                 220                 


Lys Glu Gln Ser Gln Leu Thr Ala Thr Gln Thr Arg Thr Val Asn Lys 
225                 230                 235                 240 


His Gly Asp Glu Ile Ile Thr Ser Thr Thr Ser Asn Tyr Glu Thr Gln 
                245                 250                 255     


Thr Phe Ser Ser Lys Thr Glu Trp Arg Val Arg Ala Ile Ser Ala Ala 
            260                 265                 270         


Asn Leu His Leu Arg Thr Asn His Ile Tyr Val Ser Ser Asp Asp Ile 
        275                 280                 285             


Lys Glu Thr Gly Tyr Thr Tyr Ile Leu Pro Lys Asn Val Leu Lys Lys 
    290                 295                 300                 


Phe Ile Cys Ile Ser Asp Leu Arg Ala Gln Ile Ala Gly Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Ser Pro Pro Asp Asn Pro Gln Val Lys Glu Ile Arg Cys Ile 
                325                 330                 335     


Val Met Val Pro Gln Trp Gly Thr His Gln Thr Val His Leu Pro Gly 
            340                 345                 350         


Gln Leu Pro Gln His Glu Tyr Leu Lys Glu Met Glu Pro Leu Gly Trp 
        355                 360                 365             


Ile His Thr Gln Pro Asn Glu Ser Pro Gln Leu Ser Pro Gln Asp Val 
    370                 375                 380                 


Thr Thr His Ala Lys Ile Met Ala Asp Asn Pro Ser Trp Asp Gly Glu 
385                 390                 395                 400 


Lys Thr Ile Ile Ile Thr Cys Ser Phe Thr Pro Gly Ser Cys Thr Leu 
                405                 410                 415     


Thr Ala Tyr Lys Leu Thr Pro Ser Gly Tyr Glu Trp Gly Arg Gln Asn 
            420                 425                 430         


Thr Asp Lys Gly Asn Asn Pro Lys Gly Tyr Leu Pro Ser His Tyr Glu 
        435                 440                 445             


Arg Val Gln Met Leu Leu Ser Asp Arg Phe Leu Gly Phe Phe Met Val 
    450                 455                 460                 


Pro Ala Gln Ser Ser Trp Asn Tyr Asn Phe Met Gly Val Arg His Asp 
465                 470                 475                 480 


Pro Asn Met Lys Tyr Glu Leu Gln Leu Ala Asn Pro Lys Glu Phe Tyr 
                485                 490                 495     


His Glu Val His Arg Pro Ser His Phe Leu Asn Phe Ala Leu Leu Gln 
            500                 505                 510         


Glu Gly Glu Val Tyr Ser Ala Asp Arg Glu Asp Leu Tyr Ala 
        515                 520                 525     


<210> 211
<211> 400
<212> PRT
<213> Homo sapiens

<400> 211
Gln Pro Ser Ala Ile Thr Leu Asn Arg Gln Lys Tyr Arg His Val Asp 
1               5                   10                  15      


Asn Ile Met Phe Glu Asn His Thr Val Ala Asp Arg Phe Leu Asp Phe 
            20                  25                  30          


Trp Arg Lys Thr Gly Asn Gln His Phe Gly Tyr Leu Tyr Gly Arg Tyr 
        35                  40                  45              


Thr Glu His Lys Asp Ile Pro Leu Gly Ile Arg Ala Glu Val Ala Ala 
    50                  55                  60                  


Ile Tyr Glu Pro Pro Gln Ile Gly Thr Gln Asn Ser Leu Glu Leu Leu 
65                  70                  75                  80  


Glu Asp Pro Lys Ala Glu Val Val Asp Glu Ile Ala Ala Lys Leu Gly 
                85                  90                  95      


Leu Arg Lys Val Gly Trp Ile Phe Thr Asp Leu Val Ser Glu Asp Thr 
            100                 105                 110         


Arg Lys Gly Thr Val Arg Tyr Ser Arg Asn Lys Asp Thr Tyr Phe Leu 
        115                 120                 125             


Ser Ser Glu Glu Cys Ile Thr Ala Gly Asp Phe Gln Asn Lys His Pro 
    130                 135                 140                 


Asn Met Cys Arg Leu Ser Pro Asp Gly His Phe Gly Ser Lys Phe Val 
145                 150                 155                 160 


Thr Ala Val Ala Thr Gly Gly Pro Asp Asn Gln Val His Phe Glu Gly 
                165                 170                 175     


Tyr Gln Val Ser Asn Gln Cys Met Ala Leu Val Arg Asp Glu Cys Leu 
            180                 185                 190         


Leu Pro Cys Lys Asp Ala Pro Glu Leu Gly Tyr Ala Lys Glu Ser Ser 
        195                 200                 205             


Ser Glu Gln Tyr Val Pro Asp Val Phe Tyr Lys Asp Val Asp Lys Phe 
    210                 215                 220                 


Gly Asn Glu Ile Thr Gln Leu Ala Arg Pro Leu Pro Val Glu Tyr Leu 
225                 230                 235                 240 


Ile Ile Asp Ile Thr Thr Thr Phe Pro Lys Asp Pro Val Tyr Thr Phe 
                245                 250                 255     


Ser Ile Ser Gln Asn Pro Phe Pro Ile Glu Asn Arg Asp Val Leu Gly 
            260                 265                 270         


Glu Thr Gln Asp Phe His Ser Leu Ala Thr Tyr Leu Ser Gln Asn Thr 
        275                 280                 285             


Ser Ser Val Phe Leu Asp Thr Ile Ser Asp Phe His Leu Leu Leu Phe 
    290                 295                 300                 


Leu Val Thr Asn Glu Val Met Pro Leu Gln Asp Ser Ile Ser Leu Leu 
305                 310                 315                 320 


Leu Glu Ala Val Arg Thr Arg Asn Glu Glu Leu Ala Gln Thr Trp Lys 
                325                 330                 335     


Arg Ser Glu Gln Trp Ala Thr Ile Glu Gln Leu Cys Ser Thr Val Gly 
            340                 345                 350         


Gly Gln Leu Pro Gly Leu His Glu Tyr Gly Ala Val Gly Gly Ser Thr 
        355                 360                 365             


His Thr Ala Thr Ala Ala Met Trp Ala Cys Gln His Cys Thr Phe Met 
    370                 375                 380                 


Asn Gln Pro Gly Thr Gly His Cys Glu Met Cys Ser Leu Pro Arg Thr 
385                 390                 395                 400 


<210> 212
<211> 203
<212> PRT
<213> Homo sapiens

<400> 212
Thr Gln Ala Tyr Cys Lys Met Val Leu His Gly Ala Lys Tyr Pro His 
1               5                   10                  15      


Cys Ala Val Asn Gly Leu Leu Val Ala Glu Lys Gln Lys Pro Arg Lys 
            20                  25                  30          


Glu His Leu Pro Leu Gly Gly Pro Gly Ala His His Thr Leu Phe Val 
        35                  40                  45              


Asp Cys Ile Pro Leu Phe His Gly Thr Leu Ala Leu Ala Pro Met Leu 
    50                  55                  60                  


Glu Val Ala Leu Thr Leu Ile Asp Ser Trp Cys Lys Asp His Ser Tyr 
65                  70                  75                  80  


Val Ile Ala Gly Tyr Tyr Gln Ala Asn Glu Arg Val Lys Asp Ala Ser 
                85                  90                  95      


Pro Asn Gln Val Ala Glu Lys Val Ala Ser Arg Ile Ala Glu Gly Phe 
            100                 105                 110         


Ser Asp Thr Ala Leu Ile Met Val Asp Asn Thr Lys Phe Thr Met Asp 
        115                 120                 125             


Cys Val Ala Pro Thr Ile His Val Tyr Glu His His Glu Asn Arg Trp 
    130                 135                 140                 


Arg Cys Arg Asp Pro His His Asp Tyr Cys Glu Asp Trp Pro Glu Ala 
145                 150                 155                 160 


Gln Arg Ile Ser Ala Ser Leu Leu Asp Ser Arg Ser Tyr Glu Thr Leu 
                165                 170                 175     


Val Asp Phe Asp Asn His Leu Asp Asp Ile Arg Asn Asp Trp Thr Asn 
            180                 185                 190         


Pro Glu Ile Asn Lys Ala Val Leu His Leu Cys 
        195                 200             


<210> 213
<211> 398
<212> PRT
<213> Homo sapiens

<400> 213
Gly Phe Val Leu Gly Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser 
1               5                   10                  15      


Asp Thr Glu Gly Phe Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn 
            20                  25                  30          


Ser Ile Thr Asp Ser Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile 
        35                  40                  45              


Asp Ile Gln Lys Tyr Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn 
    50                  55                  60                  


Ser Ser Gly Glu Val Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn 
65                  70                  75                  80  


Val Lys Lys Asn Val Val Gly Trp Tyr Lys Phe Arg Arg His Ser Asp 
                85                  90                  95      


Gln Ile Met Thr Phe Arg Glu Arg Leu Leu His Lys Asn Leu Gln Glu 
            100                 105                 110         


His Phe Ser Asn Gln Asp Leu Val Phe Leu Leu Leu Thr Pro Ser Ile 
        115                 120                 125             


Ile Thr Glu Ser Cys Ser Thr His Arg Leu Glu His Ser Leu Tyr Lys 
    130                 135                 140                 


Pro Gln Lys Gly Leu Phe His Arg Val Pro Leu Val Val Ala Asn Leu 
145                 150                 155                 160 


Gly Met Ser Glu Gln Leu Gly Tyr Lys Thr Val Ser Gly Ser Cys Met 
                165                 170                 175     


Ser Thr Gly Phe Ser Arg Ala Val Gln Thr His Ser Ser Lys Phe Phe 
            180                 185                 190         


Glu Glu Asp Gly Ser Leu Lys Glu Val His Lys Ile Asn Glu Met Tyr 
        195                 200                 205             


Ala Ser Leu Gln Glu Glu Leu Lys Ser Ile Cys Lys Lys Val Glu Asp 
    210                 215                 220                 


Ser Glu Gln Ala Val Asp Lys Leu Val Lys Asp Val Asn Arg Leu Lys 
225                 230                 235                 240 


Arg Glu Ile Glu Lys Arg Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu 
                245                 250                 255     


Lys Asn Ile Gln Lys Asp Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala 
            260                 265                 270         


Leu Arg Thr Phe Phe Pro Asn Ser Glu Phe Leu His Ser Cys Val Met 
        275                 280                 285             


Ser Leu Lys Asn Arg His Val Ser Lys Ser Ser Cys Asn Tyr Asn His 
    290                 295                 300                 


His Leu Asp Val Val Asp Asn Leu Thr Leu Met Val Glu His Thr Asp 
305                 310                 315                 320 


Ile Pro Glu Ala Ser Pro Ala Ser Thr Pro Gln Ile Ile Lys His Lys 
                325                 330                 335     


Ala Leu Asp Leu Asp Asp Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


Asp Thr Gln Asp Lys Arg Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln 
        355                 360                 365             


Asp Lys Ala Ser Lys Met Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu 
    370                 375                 380                 


Lys Met Lys Gly Phe Gly Glu Tyr Ser Arg Ser Pro Thr Phe 
385                 390                 395             


<210> 214
<211> 168
<212> PRT
<213> Homo sapiens

<400> 214
Val Val Leu Pro Glu Asp Leu Cys His Lys Phe Leu Gln Leu Ala Glu 
1               5                   10                  15      


Ser Asn Thr Val Arg Gly Ile Glu Thr Cys Gly Ile Leu Cys Gly Lys 
            20                  25                  30          


Leu Thr His Asn Glu Phe Thr Ile Thr His Val Ile Val Pro Lys Gln 
        35                  40                  45              


Ser Ala Gly Pro Asp Tyr Cys Asp Met Glu Asn Val Glu Glu Leu Phe 
    50                  55                  60                  


Asn Val Gln Asp Gln His Asp Leu Leu Thr Leu Gly Trp Ile His Thr 
65                  70                  75                  80  


His Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His 
                85                  90                  95      


Cys Ser Tyr Gln Leu Met Leu Pro Glu Ala Ile Ala Ile Val Cys Ser 
            100                 105                 110         


Pro Lys His Lys Asp Thr Gly Ile Phe Arg Leu Thr Asn Ala Gly Met 
        115                 120                 125             


Leu Glu Val Ser Ala Cys Lys Lys Lys Gly Phe His Pro His Thr Lys 
    130                 135                 140                 


Glu Pro Arg Leu Phe Ser Ile Cys Lys His Val Leu Val Lys Asp Ile 
145                 150                 155                 160 


Lys Ile Ile Val Leu Asp Leu Arg 
                165             


<210> 215
<211> 287
<212> PRT
<213> Homo sapiens

<400> 215
Val Ala Leu His Pro Leu Val Ile Leu Asn Ile Ser Asp His Trp Ile 
1               5                   10                  15      


Arg Met Arg Ser Gln Glu Gly Arg Pro Val Gln Val Ile Gly Ala Leu 
            20                  25                  30          


Ile Gly Lys Gln Glu Gly Arg Asn Ile Glu Val Met Asn Ser Phe Glu 
        35                  40                  45              


Leu Leu Ser His Thr Val Glu Glu Lys Ile Ile Ile Asp Lys Glu Tyr 
    50                  55                  60                  


Tyr Tyr Thr Lys Glu Glu Gln Phe Lys Gln Val Phe Lys Glu Leu Glu 
65                  70                  75                  80  


Phe Leu Gly Trp Tyr Thr Thr Gly Gly Pro Pro Asp Pro Ser Asp Ile 
                85                  90                  95      


His Val His Lys Gln Val Cys Glu Ile Ile Glu Ser Pro Leu Phe Leu 
            100                 105                 110         


Lys Leu Asn Pro Met Thr Lys His Thr Asp Leu Pro Val Ser Val Phe 
        115                 120                 125             


Glu Ser Val Ile Asp Ile Ile Asn Gly Glu Ala Thr Met Leu Phe Ala 
    130                 135                 140                 


Glu Leu Thr Tyr Thr Leu Ala Thr Glu Glu Ala Glu Arg Ile Gly Val 
145                 150                 155                 160 


Asp His Val Ala Arg Met Thr Ala Thr Gly Ser Gly Glu Asn Ser Thr 
                165                 170                 175     


Val Ala Glu His Leu Ile Ala Gln His Ser Ala Ile Lys Met Leu His 
            180                 185                 190         


Ser Arg Val Lys Leu Ile Leu Glu Tyr Val Lys Ala Ser Glu Ala Gly 
        195                 200                 205             


Glu Val Pro Phe Asn His Glu Ile Leu Arg Glu Ala Tyr Ala Leu Cys 
    210                 215                 220                 


His Cys Leu Pro Val Leu Ser Thr Asp Lys Phe Lys Thr Asp Phe Tyr 
225                 230                 235                 240 


Asp Gln Cys Asn Asp Val Gly Leu Met Ala Tyr Leu Gly Thr Ile Thr 
                245                 250                 255     


Lys Thr Cys Asn Thr Met Asn Gln Phe Val Asn Lys Phe Asn Val Leu 
            260                 265                 270         


Tyr Asp Arg Gln Gly Ile Gly Arg Arg Met Arg Gly Leu Phe Phe 
        275                 280                 285         


<210> 216
<211> 266
<212> PRT
<213> Homo sapiens

<400> 216
Val Arg Leu His Pro Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu 
1               5                   10                  15      


Arg Arg Asn Glu Gly Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr 
            20                  25                  30          


Val Asp Lys His Ser Val Glu Val Thr Asn Cys Phe Ser Val Pro His 
        35                  40                  45              


Asn Glu Ser Glu Asp Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn 
    50                  55                  60                  


Met Tyr Glu Leu His Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly 
65                  70                  75                  80  


Trp Tyr Ala Thr Gly His Asp Ile Thr Glu His Ser Val Leu Ile His 
                85                  90                  95      


Glu Tyr Tyr Ser Arg Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp 
            100                 105                 110         


Thr Ser Leu Gln Asn Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr 
        115                 120                 125             


Leu Met Gly Val Pro Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu 
    130                 135                 140                 


Thr Val Lys Tyr Ala Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu 
145                 150                 155                 160 


Ile Met Lys Thr Cys Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser 
                165                 170                 175     


Asp Leu Gln Gln Val Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu 
            180                 185                 190         


Ser Thr Val Leu Gln Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser 
        195                 200                 205             


Ala Asp Asn Thr Val Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val 
    210                 215                 220                 


Pro Lys Ile Val Pro Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile 
225                 230                 235                 240 


Asn Asp Leu Leu Met Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln 
                245                 250                 255     


Ile Ala Leu Asn Glu Lys Leu Val Asn Leu 
            260                 265     


<210> 217
<211> 316
<212> PRT
<213> Homo sapiens

<400> 217
Val Val Val His Pro Leu Val Leu Leu Ser Val Val Asp His Phe Asn 
1               5                   10                  15      


Arg Ile Gly Lys Val Gly Asn Gln Lys Arg Val Val Gly Val Leu Leu 
            20                  25                  30          


Gly Ser Trp Gln Lys Lys Val Leu Asp Val Ser Asn Ser Phe Ala Val 
        35                  40                  45              


Pro Phe Asp Glu Asp Asp Lys Asp Asp Ser Val Trp Phe Leu Asp His 
    50                  55                  60                  


Asp Tyr Leu Glu Asn Met Tyr Gly Met Phe Lys Lys Val Asn Ala Arg 
65                  70                  75                  80  


Glu Arg Ile Val Gly Trp Tyr His Thr Gly Pro Lys Leu His Lys Asn 
                85                  90                  95      


Asp Ile Ala Ile Asn Glu Leu Met Lys Arg Tyr Cys Pro Asn Ser Val 
            100                 105                 110         


Leu Val Ile Ile Asp Val Lys Pro Lys Asp Leu Gly Leu Pro Thr Glu 
        115                 120                 125             


Ala Tyr Ile Ser Val Glu Glu Val His Asp Asp Gly Thr Pro Thr Ser 
    130                 135                 140                 


Lys Thr Phe Glu His Val Thr Ser Glu Ile Gly Ala Glu Glu Ala Glu 
145                 150                 155                 160 


Glu Val Gly Val Glu His Leu Leu Arg Asp Ile Lys Asp Thr Thr Val 
                165                 170                 175     


Gly Thr Leu Ser Gln Arg Ile Thr Asn Gln Val His Gly Leu Lys Gly 
            180                 185                 190         


Leu Asn Ser Lys Leu Leu Asp Ile Arg Ser Tyr Leu Glu Lys Val Ala 
        195                 200                 205             


Thr Gly Lys Leu Pro Ile Asn His Gln Ile Ile Tyr Gln Leu Gln Asp 
    210                 215                 220                 


Val Phe Asn Leu Leu Pro Asp Val Ser Leu Gln Glu Phe Val Lys Ala 
225                 230                 235                 240 


Phe Tyr Leu Lys Thr Asn Asp Gln Met Val Val Val Tyr Leu Ala Ser 
                245                 250                 255     


Leu Ile Arg Ser Val Val Ala Leu His Asn Leu Ile Asn Asn Lys Ile 
            260                 265                 270         


Ala Asn Arg Asp Ala Glu Lys Lys Glu Gly Gln Glu Lys Glu Glu Ser 
        275                 280                 285             


Lys Lys Asp Arg Lys Glu Asp Lys Glu Lys Asp Lys Asp Lys Glu Lys 
    290                 295                 300                 


Ser Asp Val Lys Lys Glu Glu Lys Lys Glu Lys Lys 
305                 310                 315     


<210> 218
<211> 314
<212> PRT
<213> Homo sapiens

<400> 218
Val Gln Ile Asp Gly Leu Val Val Leu Lys Ile Ile Lys His Tyr Gln 
1               5                   10                  15      


Glu Glu Gly Gln Gly Thr Glu Val Val Gln Gly Val Leu Leu Gly Leu 
            20                  25                  30          


Val Val Glu Asp Arg Leu Glu Ile Thr Asn Cys Phe Pro Phe Pro Gln 
        35                  40                  45              


His Thr Glu Asp Asp Ala Asp Phe Asp Glu Val Gln Tyr Gln Met Glu 
    50                  55                  60                  


Met Met Arg Ser Leu Arg His Val Asn Ile Asp His Leu His Val Gly 
65                  70                  75                  80  


Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe Val Thr Arg Ala Leu Leu 
                85                  90                  95      


Asp Ser Gln Phe Ser Tyr Gln His Ala Ile Glu Glu Ser Val Val Leu 
            100                 105                 110         


Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly Ser Leu Ser Leu Lys Ala 
        115                 120                 125             


Tyr Arg Leu Thr Pro Lys Leu Met Glu Val Cys Lys Glu Lys Asp Phe 
    130                 135                 140                 


Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile Thr Phe Glu Tyr Met Phe 
145                 150                 155                 160 


Glu Glu Val Pro Ile Val Ile Lys Asn Ser His Leu Ile Asn Val Leu 
                165                 170                 175     


Met Trp Glu Leu Glu Lys Lys Ser Ala Val Ala Asp Lys His Glu Leu 
            180                 185                 190         


Leu Ser Leu Ala Ser Ser Asn His Leu Gly Lys Asn Leu Gln Leu Leu 
        195                 200                 205             


Met Asp Arg Val Asp Glu Met Ser Gln Asp Ile Val Lys Tyr Asn Thr 
    210                 215                 220                 


Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln Gln Lys His Gln Tyr Gln 
225                 230                 235                 240 


Gln Arg Arg Gln Gln Glu Asn Met Gln Arg Gln Ser Arg Gly Glu Pro 
                245                 250                 255     


Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu Phe Lys Pro Pro Gln Pro 
            260                 265                 270         


Pro Ala Arg Met Asp Ser Leu Leu Ile Ala Gly Gln Ile Asn Thr Tyr 
        275                 280                 285             


Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln Asn Leu Gly Lys Leu Phe 
    290                 295                 300                 


Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn 
305                 310                 


<210> 219
<211> 281
<212> PRT
<213> Homo sapiens

<400> 219
Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys Met Val Met His Ala 
1               5                   10                  15      


Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu Met Leu Gly Lys Val 
            20                  25                  30          


Asp Gly Glu Thr Met Ile Ile Met Asp Ser Phe Ala Leu Pro Val Glu 
        35                  40                  45              


Gly Thr Glu Thr Arg Val Asn Ala Gln Ala Ala Ala Tyr Glu Tyr Met 
    50                  55                  60                  


Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly Arg Leu Glu Asn Ala 
65                  70                  75                  80  


Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly Cys Trp Leu Ser Gly 
                85                  90                  95      


Ile Asp Val Ser Thr Gln Met Leu Asn Gln Gln Phe Gln Glu Pro Phe 
            100                 105                 110         


Val Ala Val Val Ile Asp Pro Thr Arg Thr Ile Ser Ala Gly Lys Val 
        115                 120                 125             


Asn Leu Gly Ala Phe Arg Thr Tyr Pro Lys Gly Tyr Lys Pro Pro Asp 
    130                 135                 140                 


Glu Gly Pro Ser Glu Tyr Gln Thr Ile Pro Leu Asn Lys Ile Glu Asp 
145                 150                 155                 160 


Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu Glu Val Ser Tyr Phe 
                165                 170                 175     


Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu Leu Trp Asn Lys Tyr 
            180                 185                 190         


Trp Val Asn Thr Leu Ser Ser Ser Ser Leu Leu Thr Asn Ala Asp Tyr 
        195                 200                 205             


Thr Thr Gly Gln Val Phe Asp Leu Ser Glu Lys Leu Glu Gln Ser Glu 
    210                 215                 220                 


Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly Leu Glu Thr His Asp 
225                 230                 235                 240 


Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Thr Arg Asp Ser Cys Lys 
                245                 250                 255     


Thr Thr Ile Glu Ala Ile His Gly Leu Met Ser Gln Val Ile Lys Asp 
            260                 265                 270         


Lys Leu Phe Asn Gln Ile Asn Ile Ser 
        275                 280     


<210> 220
<211> 305
<212> PRT
<213> Homo sapiens

<400> 220
Val His Leu Glu Ser Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu 
1               5                   10                  15      


Ser Thr Glu Lys Glu Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn 
            20                  25                  30          


Asp Asp Thr Arg Ser Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met 
        35                  40                  45              


Arg Thr Val Ala Glu Lys Val Asp Ala Val Arg Ile Val His Ile His 
    50                  55                  60                  


Ser Val Ile Ile Leu Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu 
65                  70                  75                  80  


Ile Ser Pro Glu Gln Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu 
                85                  90                  95      


Ala Glu Leu Thr Gly Arg Pro Met Arg Val Val Gly Trp Tyr His Ser 
            100                 105                 110         


His Pro His Ile Thr Val Trp Pro Ser His Val Asp Val Arg Thr Gln 
        115                 120                 125             


Ala Met Tyr Gln Met Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser 
    130                 135                 140                 


Cys Phe Ile Glu Asp Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr 
145                 150                 155                 160 


Cys Phe Gln Ser Ile Gln Ala Gln Lys Ser Ser Glu Ser Leu His Gly 
                165                 170                 175     


Pro Arg Asp Phe Trp Ser Ser Ser Gln His Ile Ser Ile Glu Gly Gln 
            180                 185                 190         


Lys Glu Glu Glu Arg Tyr Glu Arg Ile Glu Ile Pro Ile His Ile Val 
        195                 200                 205             


Pro His Val Thr Ile Gly Lys Val Cys Leu Glu Ser Ala Val Glu Leu 
    210                 215                 220                 


Pro Lys Ile Leu Cys Gln Glu Glu Gln Asp Ala Tyr Arg Arg Ile His 
225                 230                 235                 240 


Ser Leu Thr His Leu Asp Ser Val Thr Lys Ile His Asn Gly Ser Val 
                245                 250                 255     


Phe Thr Lys Asn Leu Cys Ser Gln Met Ser Ala Val Ser Gly Pro Leu 
            260                 265                 270         


Leu Gln Trp Leu Glu Asp Arg Leu Glu Gln Asn Gln Gln His Leu Gln 
        275                 280                 285             


Glu Leu Gln Gln Glu Lys Glu Glu Leu Met Gln Glu Leu Ser Ser Leu 
    290                 295                 300                 


Glu 
305 


<210> 221
<211> 960
<212> PRT
<213> Homo sapiens

<400> 221
Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
            900                 905                 910         


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
        915                 920                 925             


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
    930                 935                 940                 


Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 960 


<210> 222
<211> 1465
<212> PRT
<213> Homo sapiens

<400> 222
Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Val Ala Thr Ser Thr Val Arg Ile 
    50                  55                  60                  


Leu Gly Met Thr Cys Gln Ser Cys Val Lys Ser Ile Glu Asp Arg Ile 
65                  70                  75                  80  


Ser Asn Leu Lys Gly Ile Ile Ser Met Lys Val Ser Leu Glu Gln Gly 
                85                  90                  95      


Ser Ala Thr Val Lys Tyr Val Pro Ser Val Val Cys Leu Gln Gln Val 
            100                 105                 110         


Cys His Gln Ile Gly Asp Met Gly Phe Glu Ala Ser Ile Ala Glu Gly 
        115                 120                 125             


Lys Ala Ala Ser Trp Pro Ser Arg Ser Leu Pro Ala Gln Glu Ala Val 
    130                 135                 140                 


Val Lys Leu Arg Val Glu Gly Met Thr Cys Gln Ser Cys Val Ser Ser 
145                 150                 155                 160 


Ile Glu Gly Lys Val Arg Lys Leu Gln Gly Val Val Arg Val Lys Val 
                165                 170                 175     


Ser Leu Ser Asn Gln Glu Ala Val Ile Thr Tyr Gln Pro Tyr Leu Ile 
            180                 185                 190         


Gln Pro Glu Asp Leu Arg Asp His Val Asn Asp Met Gly Phe Glu Ala 
        195                 200                 205             


Ala Ile Lys Ser Lys Val Ala Pro Leu Ser Leu Gly Pro Ile Asp Ile 
    210                 215                 220                 


Glu Arg Leu Gln Ser Thr Asn Pro Lys Arg Pro Leu Ser Ser Ala Asn 
225                 230                 235                 240 


Gln Asn Phe Asn Asn Ser Glu Thr Leu Gly His Gln Gly Ser His Val 
                245                 250                 255     


Val Thr Leu Gln Leu Arg Ile Asp Gly Met His Cys Lys Ser Cys Val 
            260                 265                 270         


Leu Asn Ile Glu Glu Asn Ile Gly Gln Leu Leu Gly Val Gln Ser Ile 
        275                 280                 285             


Gln Val Ser Leu Glu Asn Lys Thr Ala Gln Val Lys Tyr Asp Pro Ser 
    290                 295                 300                 


Cys Thr Ser Pro Val Ala Leu Gln Arg Ala Ile Glu Ala Leu Pro Pro 
305                 310                 315                 320 


Gly Asn Phe Lys Val Ser Leu Pro Asp Gly Ala Glu Gly Ser Gly Thr 
                325                 330                 335     


Asp His Arg Ser Ser Ser Ser His Ser Pro Gly Ser Pro Pro Arg Asn 
            340                 345                 350         


Gln Val Gln Gly Thr Cys Ser Thr Thr Leu Ile Ala Ile Ala Gly Met 
        355                 360                 365             


Thr Cys Ala Ser Cys Val His Ser Ile Glu Gly Met Ile Ser Gln Leu 
    370                 375                 380                 


Glu Gly Val Gln Gln Ile Ser Val Ser Leu Ala Glu Gly Thr Ala Thr 
385                 390                 395                 400 


Val Leu Tyr Asn Pro Ser Val Ile Ser Pro Glu Glu Leu Arg Ala Ala 
                405                 410                 415     


Ile Glu Asp Met Gly Phe Glu Ala Ser Val Val Ser Glu Ser Cys Ser 
            420                 425                 430         


Thr Asn Pro Leu Gly Asn His Ser Ala Gly Asn Ser Met Val Gln Thr 
        435                 440                 445             


Thr Asp Gly Thr Pro Thr Ser Val Gln Glu Val Ala Pro His Thr Gly 
    450                 455                 460                 


Arg Leu Pro Ala Asn His Ala Pro Asp Ile Leu Ala Lys Ser Pro Gln 
465                 470                 475                 480 


Ser Thr Arg Ala Val Ala Pro Gln Lys Cys Phe Leu Gln Ile Lys Gly 
                485                 490                 495     


Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu Gln Lys 
            500                 505                 510         


Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly Lys Ala 
        515                 520                 525             


Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile Ala Gln 
    530                 535                 540                 


Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp Tyr Ala 
545                 550                 555                 560 


Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr Cys Ala 
                565                 570                 575     


Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn Gly Ile 
            580                 585                 590         


Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val Lys Phe 
        595                 600                 605             


Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile Glu Glu 
    610                 615                 620                 


Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala His His 
625                 630                 635                 640 


Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe Leu Cys 
                645                 650                 655     


Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr Met Leu 
            660                 665                 670         


Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His Asn Ile 
        675                 680                 685             


Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu Cys Thr 
    690                 695                 700                 


Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala Tyr Lys 
705                 710                 715                 720 


Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val Leu Ala 
                725                 730                 735     


Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val Ala Val 
            740                 745                 750         


Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr Pro Pro 
        755                 760                 765             


Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His Leu Ala 
    770                 775                 780                 


Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu Gln Ala 
785                 790                 795                 800 


Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile Ile Arg 
                805                 810                 815     


Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile Val Lys 
            820                 825                 830         


Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu Glu Gly 
        835                 840                 845             


Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met Pro Val 
    850                 855                 860                 


Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn Ala His 
865                 870                 875                 880 


Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr Thr Leu 
                885                 890                 895     


Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys Ala Pro 
            900                 905                 910         


Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro Phe Ile 
        915                 920                 925             


Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile Gly Phe 
    930                 935                 940                 


Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn Lys His 
945                 950                 955                 960 


Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr Ser Ile 
                965                 970                 975     


Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala Thr Pro 
            980                 985                 990         


Thr Ala Val Met Val Gly Thr Gly  Val Ala Ala Gln Asn  Gly Ile Leu 
        995                 1000                 1005             


Ile Lys  Gly Gly Lys Pro Leu  Glu Met Ala His Lys  Ile Lys Thr 
    1010                 1015                 1020             


Val Met  Phe Asp Lys Thr Gly  Thr Ile Thr His Gly  Val Pro Arg 
    1025                 1030                 1035             


Val Met  Arg Val Leu Leu Leu  Gly Asp Val Ala Thr  Leu Pro Leu 
    1040                 1045                 1050             


Arg Lys  Val Leu Ala Val Val  Gly Thr Ala Glu Ala  Ser Ser Glu 
    1055                 1060                 1065             


His Pro  Leu Gly Val Ala Val  Thr Lys Tyr Cys Lys  Glu Glu Leu 
    1070                 1075                 1080             


Gly Thr  Glu Thr Leu Gly Tyr  Cys Thr Asp Phe Gln  Ala Val Pro 
    1085                 1090                 1095             


Gly Cys  Gly Ile Gly Cys Lys  Val Ser Asn Val Glu  Gly Ile Leu 
    1100                 1105                 1110             


Ala His  Ser Glu Arg Pro Leu  Ser Ala Pro Ala Ser  His Leu Asn 
    1115                 1120                 1125             


Glu Ala  Gly Ser Leu Pro Ala  Glu Lys Asp Ala Val  Pro Gln Thr 
    1130                 1135                 1140             


Phe Ser  Val Leu Ile Gly Asn  Arg Glu Trp Leu Arg  Arg Asn Gly 
    1145                 1150                 1155             


Leu Thr  Ile Ser Ser Asp Val  Ser Asp Ala Met Thr  Asp His Glu 
    1160                 1165                 1170             


Met Lys  Gly Gln Thr Ala Ile  Leu Val Ala Ile Asp  Gly Val Leu 
    1175                 1180                 1185             


Cys Gly  Met Ile Ala Ile Ala  Asp Ala Val Lys Gln  Glu Ala Ala 
    1190                 1195                 1200             


Leu Ala  Val His Thr Leu Gln  Ser Met Gly Val Asp  Val Val Leu 
    1205                 1210                 1215             


Ile Thr  Gly Asp Asn Arg Lys  Thr Ala Arg Ala Ile  Ala Thr Gln 
    1220                 1225                 1230             


Val Gly  Ile Asn Lys Val Phe  Ala Glu Val Leu Pro  Ser His Lys 
    1235                 1240                 1245             


Val Ala  Lys Val Gln Glu Leu  Gln Asn Lys Gly Lys  Lys Val Ala 
    1250                 1255                 1260             


Met Val  Gly Asp Gly Val Asn  Asp Ser Pro Ala Leu  Ala Gln Ala 
    1265                 1270                 1275             


Asp Met  Gly Val Ala Ile Gly  Thr Gly Thr Asp Val  Ala Ile Glu 
    1280                 1285                 1290             


Ala Ala  Asp Val Val Leu Ile  Arg Asn Asp Leu Leu  Asp Val Val 
    1295                 1300                 1305             


Ala Ser  Ile His Leu Ser Lys  Arg Thr Val Arg Arg  Ile Arg Ile 
    1310                 1315                 1320             


Asn Leu  Val Leu Ala Leu Ile  Tyr Asn Leu Val Gly  Ile Pro Ile 
    1325                 1330                 1335             


Ala Ala  Gly Val Phe Met Pro  Ile Gly Ile Val Leu  Gln Pro Trp 
    1340                 1345                 1350             


Met Gly  Ser Ala Ala Met Ala  Ala Ser Ser Val Ser  Val Val Leu 
    1355                 1360                 1365             


Ser Ser  Leu Gln Leu Lys Cys  Tyr Lys Lys Pro Asp  Leu Glu Arg 
    1370                 1375                 1380             


Tyr Glu  Ala Gln Ala His Gly  His Met Lys Pro Leu  Thr Ala Ser 
    1385                 1390                 1395             


Gln Val  Ser Val His Ile Gly  Met Asp Asp Arg Trp  Arg Asp Ser 
    1400                 1405                 1410             


Pro Arg  Ala Thr Pro Trp Asp  Gln Val Ser Tyr Val  Ser Gln Val 
    1415                 1420                 1425             


Ser Leu  Ser Ser Leu Thr Ser  Asp Lys Pro Ser Arg  His Ser Ala 
    1430                 1435                 1440             


Ala Ala  Asp Asp Asp Gly Asp  Lys Trp Ser Leu Leu  Leu Asn Gly 
    1445                 1450                 1455             


Arg Asp  Glu Glu Gln Tyr Ile  
    1460                 1465 


<210> 223
<211> 594
<212> PRT
<213> Homo sapiens

<400> 223
Met Ala Pro Ile Gly Leu Lys Ala Val Val Gly Glu Lys Ile Met His 
1               5                   10                  15      


Asp Val Ile Lys Lys Val Lys Lys Lys Gly Glu Trp Lys Val Leu Val 
            20                  25                  30          


Val Asp Gln Leu Ser Met Arg Met Leu Ser Ser Cys Cys Lys Met Thr 
        35                  40                  45              


Asp Ile Met Thr Glu Gly Ile Thr Ile Val Glu Asp Ile Asn Lys Arg 
    50                  55                  60                  


Arg Glu Pro Leu Pro Ser Leu Glu Ala Val Tyr Leu Ile Thr Pro Ser 
65                  70                  75                  80  


Glu Lys Ser Val His Ser Leu Ile Ser Asp Phe Lys Asp Pro Pro Thr 
                85                  90                  95      


Ala Lys Tyr Arg Ala Ala His Val Phe Phe Thr Asp Ser Cys Pro Asp 
            100                 105                 110         


Ala Leu Phe Asn Glu Leu Val Lys Ser Arg Ala Ala Lys Val Ile Lys 
        115                 120                 125             


Thr Leu Thr Glu Ile Asn Ile Ala Phe Leu Pro Tyr Glu Ser Gln Val 
    130                 135                 140                 


Tyr Ser Leu Asp Ser Ala Asp Ser Phe Gln Ser Phe Tyr Ser Pro His 
145                 150                 155                 160 


Lys Ala Gln Met Lys Asn Pro Ile Leu Glu Arg Leu Ala Glu Gln Ile 
                165                 170                 175     


Ala Thr Leu Cys Ala Thr Leu Lys Glu Tyr Pro Ala Val Arg Tyr Arg 
            180                 185                 190         


Gly Glu Tyr Lys Asp Asn Ala Leu Leu Ala Gln Leu Ile Gln Asp Lys 
        195                 200                 205             


Leu Asp Ala Tyr Lys Ala Asp Asp Pro Thr Met Gly Glu Gly Pro Asp 
    210                 215                 220                 


Lys Ala Arg Ser Gln Leu Leu Ile Leu Asp Arg Gly Phe Asp Pro Ser 
225                 230                 235                 240 


Ser Pro Val Leu His Glu Leu Thr Phe Gln Ala Met Ser Tyr Asp Leu 
                245                 250                 255     


Leu Pro Ile Glu Asn Asp Val Tyr Lys Tyr Glu Thr Ser Gly Ile Gly 
            260                 265                 270         


Glu Ala Arg Val Lys Glu Val Leu Leu Asp Glu Asp Asp Asp Leu Trp 
        275                 280                 285             


Ile Ala Leu Arg His Lys His Ile Ala Glu Val Ser Gln Glu Val Thr 
    290                 295                 300                 


Arg Ser Leu Lys Asp Phe Ser Ser Ser Lys Arg Met Asn Thr Gly Glu 
305                 310                 315                 320 


Lys Thr Thr Met Arg Asp Leu Ser Gln Met Leu Lys Lys Met Pro Gln 
                325                 330                 335     


Tyr Gln Lys Glu Leu Ser Lys Tyr Ser Thr His Leu His Leu Ala Glu 
            340                 345                 350         


Asp Cys Met Lys His Tyr Gln Gly Thr Val Asp Lys Leu Cys Arg Val 
        355                 360                 365             


Glu Gln Asp Leu Ala Met Gly Thr Asp Ala Glu Gly Glu Lys Ile Lys 
    370                 375                 380                 


Asp Pro Met Arg Ala Ile Val Pro Ile Leu Leu Asp Ala Asn Val Ser 
385                 390                 395                 400 


Thr Tyr Asp Lys Ile Arg Ile Ile Leu Leu Tyr Ile Phe Leu Lys Asn 
                405                 410                 415     


Gly Ile Thr Glu Glu Asn Leu Asn Lys Leu Ile Gln His Ala Gln Ile 
            420                 425                 430         


Pro Pro Glu Asp Ser Glu Ile Ile Thr Asn Met Ala His Leu Gly Val 
        435                 440                 445             


Pro Ile Val Thr Asp Ser Thr Leu Arg Arg Arg Ser Lys Pro Glu Arg 
    450                 455                 460                 


Lys Glu Arg Ile Ser Glu Gln Thr Tyr Gln Leu Ser Arg Trp Thr Pro 
465                 470                 475                 480 


Ile Ile Lys Asp Ile Met Glu Asp Thr Ile Glu Asp Lys Leu Asp Thr 
                485                 490                 495     


Lys His Tyr Pro Tyr Ile Ser Thr Arg Ser Ser Ala Ser Phe Ser Thr 
            500                 505                 510         


Thr Ala Val Ser Ala Arg Tyr Gly His Trp His Lys Asn Lys Ala Pro 
        515                 520                 525             


Gly Glu Tyr Arg Ser Gly Pro Arg Leu Ile Ile Phe Ile Leu Gly Gly 
    530                 535                 540                 


Val Ser Leu Asn Glu Met Arg Cys Ala Tyr Glu Val Thr Gln Ala Asn 
545                 550                 555                 560 


Gly Lys Trp Glu Val Leu Ile Gly Ser Thr His Ile Leu Thr Pro Gln 
                565                 570                 575     


Lys Leu Leu Asp Thr Leu Lys Lys Leu Asn Lys Thr Asp Glu Glu Ile 
            580                 585                 590         


Ser Ser 
        


<210> 224
<211> 1343
<212> PRT
<213> Homo sapiens

<400> 224
Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala Met 
1               5                   10                  15      


Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg Thr 
            20                  25                  30          


Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg Phe 
        35                  40                  45              


Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu Ile 
    50                  55                  60                  


His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn Lys 
65                  70                  75                  80  


Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His Gly 
                85                  90                  95      


Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg Pro 
        115                 120                 125             


Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg Thr 
    130                 135                 140                 


Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile Leu 
145                 150                 155                 160 


Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln Ser 
                165                 170                 175     


Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser Ala 
            180                 185                 190         


Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys Pro 
        195                 200                 205             


Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr Thr 
    210                 215                 220                 


Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg Asp 
225                 230                 235                 240 


Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp Asn 
                245                 250                 255     


Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala Arg 
            260                 265                 270         


Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp Asp 
        275                 280                 285             


Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly Asp 
    290                 295                 300                 


Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala Val 
305                 310                 315                 320 


Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg Lys 
                325                 330                 335     


Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala Thr 
            340                 345                 350         


Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu Pro 
        355                 360                 365             


Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala Val 
385                 390                 395                 400 


Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu Leu 
                405                 410                 415     


Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu Cys 
            420                 425                 430         


Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val Ala 
        435                 440                 445             


Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp Phe 
    450                 455                 460                 


Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg Glu 
465                 470                 475                 480 


His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu Glu 
                485                 490                 495     


Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly Glu 
            500                 505                 510         


Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp Pro 
        515                 520                 525             


Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu Arg 
    530                 535                 540                 


Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys Val 
545                 550                 555                 560 


Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg Cys 
                565                 570                 575     


Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala Ser 
            580                 585                 590         


Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe 
        595                 600                 605             


Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu Thr 
    610                 615                 620                 


Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe Thr 
625                 630                 635                 640 


Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu Glu 
                645                 650                 655     


Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp Thr 
            660                 665                 670         


Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu 
        675                 680                 685             


Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu Ser 
    690                 695                 700                 


Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn Asp 
705                 710                 715                 720 


Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser Arg 
                725                 730                 735     


Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro Ser 
            740                 745                 750         


Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Ile Asp 
        755                 760                 765             


Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser Met Asp Met Ala 
    770                 775                 780                 


Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro Pro Gly 
785                 790                 795                 800 


Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Leu Ala Arg Ser 
                805                 810                 815     


Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr Glu Pro Glu Gln 
            820                 825                 830         


Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu Asp Leu Gln Gly 
        835                 840                 845             


Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val Ser Asn Leu Ala 
    850                 855                 860                 


Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser Leu Thr Ala Ala 
865                 870                 875                 880 


Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser Gln Gly Ser Gly 
                885                 890                 895     


Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln Met Gly Val Thr 
            900                 905                 910         


Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro Leu Ser Phe Gln 
        915                 920                 925             


Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly Pro Pro Gly Gly 
    930                 935                 940                 


His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser His His His His 
945                 950                 955                 960 


His His His His His His Arg Gly Gly Glu Pro Pro Gly Asp Thr Phe 
                965                 970                 975     


Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu Ser Ser Gly Val 
            980                 985                 990         


Pro Lys Pro Pro Ala Ala Ser Ile  Leu His Ser His Ser  Tyr Ser Asp 
        995                 1000                 1005             


Glu Phe  Gly Pro Ser Gly Thr  Asp Phe Thr Arg Arg  Gln Leu Ser 
    1010                 1015                 1020             


Leu Gln  Asp Asn Leu Gln His  Met Leu Ser Pro Pro  Gln Ile Thr 
    1025                 1030                 1035             


Ile Gly  Pro Gln Arg Pro Ala  Pro Ser Gly Pro Gly  Gly Gly Ser 
    1040                 1045                 1050             


Gly Gly  Gly Ser Gly Gly Gly  Gly Gly Gly Gln Pro  Pro Pro Leu 
    1055                 1060                 1065             


Gln Arg  Gly Lys Ser Gln Gln  Leu Thr Val Ser Ala  Ala Gln Lys 
    1070                 1075                 1080             


Pro Arg  Pro Ser Ser Gly Asn  Leu Leu Gln Ser Pro  Glu Pro Ser 
    1085                 1090                 1095             


Tyr Gly  Pro Ala Arg Pro Arg  Gln Gln Ser Leu Ser  Lys Glu Gly 
    1100                 1105                 1110             


Ser Ile  Gly Gly Ser Gly Gly  Ser Gly Gly Gly Gly  Gly Gly Gly 
    1115                 1120                 1125             


Leu Lys  Pro Ser Ile Thr Lys  Gln His Ser Gln Thr  Pro Ser Thr 
    1130                 1135                 1140             


Leu Asn  Pro Thr Met Pro Ala  Ser Glu Arg Thr Val  Ala Trp Val 
    1145                 1150                 1155             


Ser Asn  Met Pro His Leu Ser  Ala Asp Ile Glu Ser  Ala His Ile 
    1160                 1165                 1170             


Glu Arg  Glu Glu Tyr Lys Leu  Lys Glu Tyr Ser Lys  Ser Met Asp 
    1175                 1180                 1185             


Glu Ser  Arg Leu Asp Arg Val  Lys Glu Tyr Glu Glu  Glu Ile His 
    1190                 1195                 1200             


Ser Leu  Lys Glu Arg Leu His  Met Ser Asn Arg Lys  Leu Glu Glu 
    1205                 1210                 1215             


Tyr Glu  Arg Arg Leu Leu Ser  Gln Glu Glu Gln Thr  Ser Lys Ile 
    1220                 1225                 1230             


Leu Met  Gln Tyr Gln Ala Arg  Leu Glu Gln Ser Glu  Lys Arg Leu 
    1235                 1240                 1245             


Arg Gln  Gln Gln Ala Glu Lys  Asp Ser Gln Ile Lys  Ser Ile Ile 
    1250                 1255                 1260             


Gly Arg  Leu Met Leu Val Glu  Glu Glu Leu Arg Arg  Asp His Pro 
    1265                 1270                 1275             


Ala Met  Ala Glu Pro Leu Pro  Glu Pro Lys Lys Arg  Leu Leu Asp 
    1280                 1285                 1290             


Ala Gln  Glu Arg Gln Leu Pro  Pro Leu Gly Pro Thr  Asn Pro Arg 
    1295                 1300                 1305             


Val Thr  Leu Ala Pro Pro Trp  Asn Gly Leu Ala Pro  Pro Ala Pro 
    1310                 1315                 1320             


Pro Pro  Pro Pro Arg Leu Gln  Ile Thr Glu Asn Gly  Glu Phe Arg 
    1325                 1330                 1335             


Asn Thr  Ala Asp His 
    1340             


<210> 225
<211> 593
<212> PRT
<213> Homo sapiens

<400> 225
Met Trp Thr Leu Val Ser Trp Val Ala Leu Thr Ala Gly Leu Val Ala 
1               5                   10                  15      


Gly Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu 
            20                  25                  30          


Asp Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys 
        35                  40                  45              


Trp Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp 
    50                  55                  60                  


Ala His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr 
65                  70                  75                  80  


Ser Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His 
                85                  90                  95      


His Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys 
            100                 105                 110         


Phe Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp 
        115                 120                 125             


Ser Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp 
    130                 135                 140                 


Gly Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp 
145                 150                 155                 160 


Arg Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr 
                165                 170                 175     


Arg Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro 
            180                 185                 190         


Ala Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys 
        195                 200                 205             


Pro Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu 
    210                 215                 220                 


Pro Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys 
225                 230                 235                 240 


Ser Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile 
                245                 250                 255     


Gln Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr 
            260                 265                 270         


Lys Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val 
        275                 280                 285             


Ser Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp 
    290                 295                 300                 


Gly Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His 
305                 310                 315                 320 


Cys Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu 
                325                 330                 335     


Gln Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu 
            340                 345                 350         


Ser Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn 
        355                 360                 365             


Val Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly 
    370                 375                 380                 


Glu Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His 
385                 390                 395                 400 


Gln His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys 
                405                 410                 415     


Gln Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg 
            420                 425                 430         


Arg Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr 
        435                 440                 445             


Ser Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp 
    450                 455                 460                 


Ala Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His 
465                 470                 475                 480 


Cys Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu 
                485                 490                 495     


Lys Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro 
            500                 505                 510         


His Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His 
        515                 520                 525             


Asp Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys 
    530                 535                 540                 


Pro Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro 
545                 550                 555                 560 


Ala Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu 
                565                 570                 575     


Ala Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu 
            580                 585                 590         


Leu 
    


<210> 226
<211> 1218
<212> PRT
<213> Homo sapiens

<400> 226
Met Arg Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 
1               5                   10                  15      


Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 
            20                  25                  30          


Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly Glu 
        35                  40                  45              


Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro Gly Asp Arg 
    50                  55                  60                  


Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe Lys Val Cys Leu Lys 
65                  70                  75                  80  


Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly Pro Cys Ser Phe Gly Ser 
                85                  90                  95      


Gly Ser Thr Pro Val Ile Gly Gly Asn Thr Phe Asn Leu Lys Ala Ser 
            100                 105                 110         


Arg Gly Asn Asp Arg Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 
        115                 120                 125             


Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 
    130                 135                 140                 


Thr Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 
145                 150                 155                 160 


Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly Val 
                165                 170                 175     


Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp Tyr Tyr Tyr 
            180                 185                 190         


Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg Asp Asp Phe Phe Gly 
        195                 200                 205             


His Tyr Ala Cys Asp Gln Asn Gly Asn Lys Thr Cys Met Glu Gly Trp 
    210                 215                 220                 


Met Gly Pro Glu Cys Asn Arg Ala Ile Cys Arg Gln Gly Cys Ser Pro 
225                 230                 235                 240 


Lys His Gly Ser Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 
                245                 250                 255     


Trp Gln Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 
            260                 265                 270         


His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 
        275                 280                 285             


Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His Gln 
    290                 295                 300                 


Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro Asp Lys Tyr 
305                 310                 315                 320 


Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly Pro Asn Cys Glu Ile Ala 
                325                 330                 335     


Glu His Ala Cys Leu Ser Asp Pro Cys His Asn Arg Gly Ser Cys Lys 
            340                 345                 350         


Glu Thr Ser Leu Gly Phe Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 
        355                 360                 365             


Pro Thr Cys Ser Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 
    370                 375                 380                 


His Gly Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 
385                 390                 395                 400 


Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys 
                405                 410                 415     


Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu Ile Ala 
            420                 425                 430         


Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly Gln Asn Cys Asp 
        435                 440                 445             


Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys Gln Asn Asp Ala Ser Cys 
    450                 455                 460                 


Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile Cys Pro Pro Gly Tyr Ala 
465                 470                 475                 480 


Gly Asp His Cys Glu Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 
                485                 490                 495     


Leu Asn Gly Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 
            500                 505                 510         


Cys Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 
        515                 520                 525             


Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala 
    530                 535                 540                 


Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys Asn Cys 
545                 550                 555                 560 


Ser His Leu Lys Asp His Cys Arg Thr Thr Pro Cys Glu Val Ile Asp 
                565                 570                 575     


Ser Cys Thr Val Ala Met Ala Ser Asn Asp Thr Pro Glu Gly Val Arg 
            580                 585                 590         


Tyr Ile Ser Ser Asn Val Cys Gly Pro His Gly Lys Cys Lys Ser Gln 
        595                 600                 605             


Ser Gly Gly Lys Phe Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 
    610                 615                 620                 


Tyr Cys His Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 
625                 630                 635                 640 


Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 
                645                 650                 655     


Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys Ser 
            660                 665                 670         


Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu Val Asn Asp 
        675                 680                 685             


Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly Lys Thr Cys His Ser 
    690                 695                 700                 


Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys Asn Asn Gly Gly Thr Cys 
705                 710                 715                 720 


Tyr Asp Glu Gly Asp Ala Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 
                725                 730                 735     


Gly Thr Thr Cys Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 
            740                 745                 750         


Cys His Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 
        755                 760                 765             


Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 
    770                 775                 780                 


Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp Gly 
785                 790                 795                 800 


Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp 
                805                 810                 815     


Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser Ser Pro Cys Ala Phe Gly 
            820                 825                 830         


Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr Arg Cys Val Cys Pro Pro 
        835                 840                 845             


Gly His Ser Gly Ala Lys Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 
    850                 855                 860                 


Thr Met Gly Ser Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 
865                 870                 875                 880 


Asn Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 
                885                 890                 895     


Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro 
            900                 905                 910         


Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe Val His 
        915                 920                 925             


Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser Leu Gln Pro Val 
    930                 935                 940                 


Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr Gln Asp Asn Cys Ala Asn 
945                 950                 955                 960 


Ile Thr Phe Thr Phe Asn Lys Glu Met Met Ser Pro Gly Leu Thr Thr 
                965                 970                 975     


Glu His Ile Cys Ser Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 
            980                 985                 990         


Ser Ala Glu Tyr Ser Ile Tyr Ile  Ala Cys Glu Pro Ser  Pro Ser Ala 
        995                 1000                 1005             


Asn Asn  Glu Ile His Val Ala  Ile Ser Ala Glu Asp  Ile Arg Asp 
    1010                 1015                 1020             


Asp Gly  Asn Pro Ile Lys Glu  Ile Thr Asp Lys Ile  Ile Asp Leu 
    1025                 1030                 1035             


Val Ser  Lys Arg Asp Gly Asn  Ser Ser Leu Ile Ala  Ala Val Ala 
    1040                 1045                 1050             


Glu Val  Arg Val Gln Arg Arg  Pro Leu Lys Asn Arg  Thr Asp Phe 
    1055                 1060                 1065             


Leu Val  Pro Leu Leu Ser Ser  Val Leu Thr Val Ala  Trp Ile Cys 
    1070                 1075                 1080             


Cys Leu  Val Thr Ala Phe Tyr  Trp Cys Leu Arg Lys  Arg Arg Lys 
    1085                 1090                 1095             


Pro Gly  Ser His Thr His Ser  Ala Ser Glu Asp Asn  Thr Thr Asn 
    1100                 1105                 1110             


Asn Val  Arg Glu Gln Leu Asn  Gln Ile Lys Asn Pro  Ile Glu Lys 
    1115                 1120                 1125             


His Gly  Ala Asn Thr Val Pro  Ile Lys Asp Tyr Glu  Asn Lys Asn 
    1130                 1135                 1140             


Ser Lys  Met Ser Lys Ile Arg  Thr His Asn Ser Glu  Val Glu Glu 
    1145                 1150                 1155             


Asp Asp  Met Asp Lys His Gln  Gln Lys Ala Arg Phe  Ala Lys Gln 
    1160                 1165                 1170             


Pro Ala  Tyr Thr Leu Val Asp  Arg Glu Glu Lys Pro  Pro Asn Gly 
    1175                 1180                 1185             


Thr Pro  Thr Lys His Pro Asn  Trp Thr Asn Lys Gln  Asp Asn Arg 
    1190                 1195                 1200             


Asp Leu  Glu Ser Ala Gln Ser  Leu Asn Arg Met Glu  Tyr Ile Val 
    1205                 1210                 1215             


<210> 227
<211> 1603
<212> PRT
<213> Homo sapiens

<400> 227
Met Arg Thr Thr Lys Val Tyr Lys Leu Val Ile His Lys Lys Gly Phe 
1               5                   10                  15      


Gly Gly Ser Asp Asp Glu Leu Val Val Asn Pro Lys Val Phe Pro His 
            20                  25                  30          


Ile Lys Leu Gly Asp Ile Val Glu Ile Ala His Pro Asn Asp Glu Tyr 
        35                  40                  45              


Ser Pro Leu Leu Leu Gln Val Lys Ser Leu Lys Glu Asp Leu Gln Lys 
    50                  55                  60                  


Glu Thr Ile Ser Val Asp Gln Thr Val Thr Gln Val Phe Arg Leu Arg 
65                  70                  75                  80  


Pro Tyr Gln Asp Val Tyr Val Asn Val Val Asp Pro Lys Asp Val Thr 
                85                  90                  95      


Leu Asp Leu Val Glu Leu Thr Phe Lys Asp Gln Tyr Ile Gly Arg Gly 
            100                 105                 110         


Asp Met Trp Arg Leu Lys Lys Ser Leu Val Ser Thr Cys Ala Tyr Ile 
        115                 120                 125             


Thr Gln Lys Val Glu Phe Ala Gly Ile Arg Ala Gln Ala Gly Glu Leu 
    130                 135                 140                 


Trp Val Lys Asn Glu Lys Val Met Cys Gly Tyr Ile Ser Glu Asp Thr 
145                 150                 155                 160 


Arg Val Val Phe Arg Ser Thr Ser Ala Met Val Tyr Ile Phe Ile Gln 
                165                 170                 175     


Met Ser Cys Glu Met Trp Asp Phe Asp Ile Tyr Gly Asp Leu Tyr Phe 
            180                 185                 190         


Glu Lys Ala Val Asn Gly Phe Leu Ala Asp Leu Phe Thr Lys Trp Lys 
        195                 200                 205             


Glu Lys Asn Cys Ser His Glu Val Thr Val Val Leu Phe Ser Arg Thr 
    210                 215                 220                 


Phe Tyr Asp Ala Lys Ser Val Asp Glu Phe Pro Glu Ile Asn Arg Ala 
225                 230                 235                 240 


Ser Ile Arg Gln Asp His Lys Gly Arg Phe Tyr Glu Asp Phe Tyr Lys 
                245                 250                 255     


Val Val Val Gln Asn Glu Arg Arg Glu Glu Trp Thr Ser Leu Leu Val 
            260                 265                 270         


Thr Ile Lys Lys Leu Phe Ile Gln Tyr Pro Val Leu Val Arg Leu Glu 
        275                 280                 285             


Gln Ala Glu Gly Phe Pro Gln Gly Asp Asn Ser Thr Ser Ala Gln Gly 
    290                 295                 300                 


Asn Tyr Leu Glu Ala Ile Asn Leu Ser Phe Asn Val Phe Asp Lys His 
305                 310                 315                 320 


Tyr Ile Asn Arg Asn Phe Asp Arg Thr Gly Gln Met Ser Val Val Ile 
                325                 330                 335     


Thr Pro Gly Val Gly Val Phe Glu Val Asp Arg Leu Leu Met Ile Leu 
            340                 345                 350         


Thr Lys Gln Arg Met Ile Asp Asn Gly Ile Gly Val Asp Leu Val Cys 
        355                 360                 365             


Met Gly Glu Gln Pro Leu His Ala Val Pro Leu Phe Lys Leu His Asn 
    370                 375                 380                 


Arg Ser Ala Pro Arg Asp Ser Arg Leu Gly Asp Asp Tyr Asn Ile Pro 
385                 390                 395                 400 


His Trp Ile Asn His Ser Phe Tyr Thr Ser Lys Ser Gln Leu Phe Cys 
                405                 410                 415     


Asn Ser Phe Thr Pro Arg Ile Lys Leu Ala Gly Lys Lys Pro Ala Ser 
            420                 425                 430         


Glu Lys Ala Lys Asn Gly Arg Asp Thr Ser Leu Gly Ser Pro Lys Glu 
        435                 440                 445             


Ser Glu Asn Ala Leu Pro Ile Gln Val Asp Tyr Asp Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Val Phe Arg Leu Pro Gly Pro Ser Arg Ala Gln Cys Leu Thr Thr 
465                 470                 475                 480 


Cys Arg Ser Val Arg Glu Arg Glu Ser His Ser Arg Lys Ser Ala Ser 
                485                 490                 495     


Ser Cys Asp Val Ser Ser Ser Pro Ser Leu Pro Ser Arg Thr Leu Pro 
            500                 505                 510         


Thr Glu Glu Val Arg Ser Gln Ala Ser Asp Asp Ser Ser Leu Gly Lys 
        515                 520                 525             


Ser Ala Asn Ile Leu Met Ile Pro His Pro His Leu His Gln Tyr Glu 
    530                 535                 540                 


Val Ser Ser Ser Leu Gly Tyr Thr Ser Thr Arg Asp Val Leu Glu Asn 
545                 550                 555                 560 


Met Met Glu Pro Pro Gln Arg Asp Ser Ser Ala Pro Gly Arg Phe His 
                565                 570                 575     


Val Gly Ser Ala Glu Ser Met Leu His Val Arg Pro Gly Gly Tyr Thr 
            580                 585                 590         


Pro Gln Arg Ala Leu Ile Asn Pro Phe Ala Pro Ser Arg Met Pro Met 
        595                 600                 605             


Lys Leu Thr Ser Asn Arg Arg Arg Trp Met His Thr Phe Pro Val Gly 
    610                 615                 620                 


Pro Ser Gly Glu Ala Ile Gln Ile His His Gln Thr Arg Gln Asn Met 
625                 630                 635                 640 


Ala Glu Leu Gln Gly Ser Gly Gln Arg Asp Pro Thr His Ser Ser Ala 
                645                 650                 655     


Glu Leu Leu Glu Leu Ala Tyr His Glu Ala Ala Gly Arg His Ser Asn 
            660                 665                 670         


Ser Arg Gln Pro Gly Asp Gly Met Ser Phe Leu Asn Phe Ser Gly Thr 
        675                 680                 685             


Glu Glu Leu Ser Val Gly Leu Leu Ser Asn Ser Gly Ala Gly Met Asn 
    690                 695                 700                 


Pro Arg Thr Gln Asn Lys Asp Ser Leu Glu Asp Ser Val Ser Thr Ser 
705                 710                 715                 720 


Pro Asp Pro Ile Leu Thr Leu Ser Ala Pro Pro Val Val Pro Gly Phe 
                725                 730                 735     


Cys Cys Thr Val Gly Val Asp Trp Lys Ser Leu Thr Thr Pro Ala Cys 
            740                 745                 750         


Leu Pro Leu Thr Thr Asp Tyr Phe Pro Asp Arg Gln Gly Leu Gln Asn 
        755                 760                 765             


Asp Tyr Thr Glu Gly Cys Tyr Asp Leu Leu Pro Glu Ala Asp Ile Asp 
    770                 775                 780                 


Arg Arg Asp Glu Asp Gly Val Gln Met Thr Ala Gln Gln Val Phe Glu 
785                 790                 795                 800 


Glu Phe Ile Cys Gln Arg Leu Met Gln Gly Tyr Gln Ile Ile Val Gln 
                805                 810                 815     


Pro Lys Thr Gln Lys Pro Asn Pro Ala Val Pro Pro Pro Leu Ser Ser 
            820                 825                 830         


Ser Pro Leu Tyr Ser Arg Gly Leu Val Ser Arg Asn Arg Pro Glu Glu 
        835                 840                 845             


Glu Asp Gln Tyr Trp Leu Ser Met Gly Arg Thr Phe His Lys Val Thr 
    850                 855                 860                 


Leu Lys Asp Lys Met Ile Thr Val Thr Arg Tyr Leu Pro Lys Tyr Pro 
865                 870                 875                 880 


Tyr Glu Ser Ala Gln Ile His Tyr Thr Tyr Ser Leu Cys Pro Ser His 
                885                 890                 895     


Ser Asp Ser Glu Phe Val Ser Cys Trp Val Glu Phe Ser His Glu Arg 
            900                 905                 910         


Leu Glu Glu Tyr Lys Trp Asn Tyr Leu Asp Gln Tyr Ile Cys Ser Ala 
        915                 920                 925             


Gly Ser Glu Asp Phe Ser Leu Ile Glu Ser Leu Lys Phe Trp Arg Thr 
    930                 935                 940                 


Arg Phe Leu Leu Leu Pro Ala Cys Val Thr Ala Thr Lys Arg Ile Thr 
945                 950                 955                 960 


Glu Gly Glu Ala His Cys Asp Ile Tyr Gly Asp Arg Pro Arg Ala Asp 
                965                 970                 975     


Glu Asp Glu Trp Gln Leu Leu Asp Gly Phe Val Arg Phe Val Glu Gly 
            980                 985                 990         


Leu Asn Arg Ile Arg Arg Arg His  Arg Ser Asp Arg Met  Met Arg Lys 
        995                 1000                 1005             


Gly Thr  Ala Met Lys Gly Leu  Gln Met Thr Gly Pro  Ile Ser Thr 
    1010                 1015                 1020             


His Ser  Leu Glu Ser Thr Ala  Pro Pro Val Gly Lys  Lys Gly Thr 
    1025                 1030                 1035             


Ser Ala  Leu Ser Ala Leu Leu  Glu Met Glu Ala Ser  Gln Lys Cys 
    1040                 1045                 1050             


Leu Gly  Glu Gln Gln Ala Ala  Val His Gly Gly Lys  Ser Ser Ala 
    1055                 1060                 1065             


Gln Ser  Ala Glu Ser Ser Ser  Val Ala Met Thr Pro  Thr Tyr Met 
    1070                 1075                 1080             


Asp Ser  Pro Arg Lys Asp Gly  Ala Phe Phe Met Glu  Phe Val Arg 
    1085                 1090                 1095             


Ser Pro  Arg Thr Ala Ser Ser  Ala Phe Tyr Pro Gln  Val Ser Val 
    1100                 1105                 1110             


Asp Gln  Thr Ala Thr Pro Met  Leu Asp Gly Thr Ser  Leu Gly Ile 
    1115                 1120                 1125             


Cys Thr  Gly Gln Ser Met Asp  Arg Gly Asn Ser Gln  Thr Phe Gly 
    1130                 1135                 1140             


Asn Ser  Gln Asn Ile Gly Glu  Gln Gly Tyr Ser Ser  Thr Asn Ser 
    1145                 1150                 1155             


Ser Asp  Ser Ser Ser Gln Gln  Leu Val Ala Ser Ser  Leu Thr Ser 
    1160                 1165                 1170             


Ser Ser  Thr Leu Thr Glu Ile  Leu Glu Ala Met Lys  His Pro Ser 
    1175                 1180                 1185             


Thr Gly  Val Gln Leu Leu Ser  Glu Gln Lys Gly Leu  Ser Pro Tyr 
    1190                 1195                 1200             


Cys Phe  Ile Ser Ala Glu Val  Val His Trp Leu Val  Asn His Val 
    1205                 1210                 1215             


Glu Gly  Ile Gln Thr Gln Ala  Met Ala Ile Asp Ile  Met Gln Lys 
    1220                 1225                 1230             


Met Leu  Glu Glu Gln Leu Ile  Thr His Ala Ser Gly  Glu Ala Trp 
    1235                 1240                 1245             


Arg Thr  Phe Ile Tyr Gly Phe  Tyr Phe Tyr Lys Ile  Val Thr Asp 
    1250                 1255                 1260             


Lys Glu  Pro Asp Arg Val Ala  Met Gln Gln Pro Ala  Thr Thr Trp 
    1265                 1270                 1275             


His Thr  Ala Gly Val Asp Asp  Phe Ala Ser Phe Gln  Arg Lys Trp 
    1280                 1285                 1290             


Phe Glu  Val Ala Phe Val Ala  Glu Glu Leu Val His  Ser Glu Ile 
    1295                 1300                 1305             


Pro Ala  Phe Leu Leu Pro Trp  Leu Pro Ser Arg Pro  Ala Ser Tyr 
    1310                 1315                 1320             


Ala Ser  Arg His Ser Ser Phe  Ser Arg Ser Phe Gly  Gly Arg Ser 
    1325                 1330                 1335             


Gln Ala  Ala Ala Leu Leu Ala  Ala Thr Val Pro Glu  Gln Arg Thr 
    1340                 1345                 1350             


Val Thr  Leu Asp Val Asp Val  Asn Asn Arg Thr Asp  Arg Leu Glu 
    1355                 1360                 1365             


Trp Cys  Ser Cys Tyr Tyr His  Gly Asn Phe Ser Leu  Asn Ala Ala 
    1370                 1375                 1380             


Phe Glu  Ile Lys Leu His Trp  Met Ala Val Thr Ala  Ala Val Leu 
    1385                 1390                 1395             


Phe Glu  Met Val Gln Gly Trp  His Arg Lys Ala Thr  Ser Cys Gly 
    1400                 1405                 1410             


Phe Leu  Leu Val Pro Val Leu  Glu Gly Pro Phe Ala  Leu Pro Ser 
    1415                 1420                 1425             


Tyr Leu  Tyr Gly Asp Pro Leu  Arg Ala Gln Leu Phe  Ile Pro Leu 
    1430                 1435                 1440             


Asn Ile  Ser Cys Leu Leu Lys  Glu Gly Ser Glu His  Leu Phe Asp 
    1445                 1450                 1455             


Ser Phe  Glu Pro Glu Thr Tyr  Trp Asp Arg Met His  Leu Phe Gln 
    1460                 1465                 1470             


Glu Ala  Ile Ala His Arg Phe  Gly Phe Val Gln Asp  Lys Tyr Ser 
    1475                 1480                 1485             


Ala Ser  Ala Phe Asn Phe Pro  Ala Glu Asn Lys Pro  Gln Tyr Ile 
    1490                 1495                 1500             


His Val  Thr Gly Thr Val Phe  Leu Gln Leu Pro Tyr  Ser Lys Arg 
    1505                 1510                 1515             


Lys Phe  Ser Gly Gln Gln Arg  Arg Arg Arg Asn Ser  Thr Ser Ser 
    1520                 1525                 1530             


Thr Asn  Gln Asn Met Phe Cys  Glu Glu Arg Val Gly  Tyr Asn Trp 
    1535                 1540                 1545             


Ala Tyr  Asn Thr Met Leu Thr  Lys Thr Trp Arg Ser  Ser Ala Thr 
    1550                 1555                 1560             


Gly Asp  Glu Lys Phe Ala Asp  Arg Leu Leu Lys Asp  Phe Thr Asp 
    1565                 1570                 1575             


Phe Cys  Ile Asn Arg Asp Asn  Arg Leu Val Thr Phe  Trp Thr Ser 
    1580                 1585                 1590             


Cys Leu  Glu Lys Met His Ala  Ser Ala Pro 
    1595                 1600             


<210> 228
<211> 1807
<212> PRT
<213> Homo sapiens

<400> 228
Met Ala Lys Pro Thr Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys 
1               5                   10                  15      


Ile Leu Leu Gly Leu Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu 
            20                  25                  30          


Gly Lys Gln Thr Glu Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu 
        35                  40                  45              


Ser Met Glu Cys Gly Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile 
    50                  55                  60                  


Cys Glu Val Ala Lys Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala 
65                  70                  75                  80  


Leu Trp Lys Ala Val Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu 
                85                  90                  95      


Ala Arg His Ala Val Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln 
            100                 105                 110         


Gly Glu Arg Leu Gly Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys 
        115                 120                 125             


Asp Tyr Pro Ser Asn Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys 
    130                 135                 140                 


Ala Leu Thr Asp Asn Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu 
145                 150                 155                 160 


Ala Asp Phe Val Leu Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe 
                165                 170                 175     


Leu Leu Val Leu Val Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp 
            180                 185                 190         


Glu Tyr Ile Ala Arg Met Val Gln Met Ile Cys Leu Leu Cys Val Arg 
        195                 200                 205             


Thr Ala Ser Ser Val Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala 
    210                 215                 220                 


Val Val Cys Tyr Asn Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile 
225                 230                 235                 240 


Val Thr Leu Cys Arg Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys 
                245                 250                 255     


Trp Lys Leu Met Arg Asn Leu Leu Gly Thr His Leu Gly His Ser Ala 
            260                 265                 270         


Ile Tyr Asn Met Cys His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp 
        275                 280                 285             


Ala Pro Leu Leu Arg Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp 
    290                 295                 300                 


Gly Ala His Arg Leu Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu 
305                 310                 315                 320 


Pro Ser Phe Tyr Gln Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr 
                325                 330                 335     


Glu Ile Val Leu Ser Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu 
            340                 345                 350         


Leu Gln Val Val Ala Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu 
        355                 360                 365             


Leu Gln Gln Leu Gln Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val 
    370                 375                 380                 


His Asp Leu Leu Thr Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe 
385                 390                 395                 400 


His Gly Ser Gln Glu Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp 
                405                 410                 415     


Gln Arg Pro Glu Ser Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln 
            420                 425                 430         


Ser Ile His Pro Ala Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu 
        435                 440                 445             


Met Glu Arg Phe Phe Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys 
    450                 455                 460                 


Val Leu Asp Val Leu Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr 
465                 470                 475                 480 


Glu Glu Glu Leu Ile Asn Ser Val Val Ile Ser Gln Leu Ser His Ile 
                485                 490                 495     


Pro Glu Asp Lys Asp His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu 
            500                 505                 510         


Val Asp Leu Ala Glu Gly Cys His Thr His His Phe Asn Ser Leu Leu 
        515                 520                 525             


Asp Ile Ile Glu Lys Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu 
    530                 535                 540                 


Leu Glu Glu Arg Asp Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val 
545                 550                 555                 560 


Lys Thr Ala Val Leu Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr 
                565                 570                 575     


Thr Leu Pro Ala Ser His Ala Thr Arg Val Tyr Glu Met Leu Val Ser 
            580                 585                 590         


His Ile Gln Leu His Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser 
        595                 600                 605             


Ser Ile Arg Leu Gln Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp 
    610                 615                 620                 


Ser Leu His Arg Leu Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe 
625                 630                 635                 640 


Ser Pro Tyr Cys Val Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu 
                645                 650                 655     


Lys Lys Thr Ser Gly Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro 
            660                 665                 670         


Ala Pro Ala Gly Pro Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu 
        675                 680                 685             


Leu Phe Arg Val Leu Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys 
    690                 695                 700                 


Val Leu Lys Leu Val Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys 
705                 710                 715                 720 


Val Leu Ile Phe Thr Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala 
                725                 730                 735     


Leu Cys Ser Met Leu Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly 
            740                 745                 750         


Ala Pro Glu Gly Phe Ser Arg Thr Asp Leu His Leu Ala Val Val Pro 
        755                 760                 765             


Val Leu Thr Ala Leu Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys 
    770                 775                 780                 


Gln Arg Glu Met Val Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys 
785                 790                 795                 800 


Ala Ser Gln Cys Val Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro 
                805                 810                 815     


Asp Ile Ile Ile Lys Ala Leu Pro Val Leu Val Val Lys Leu Thr His 
            820                 825                 830         


Ile Ser Ala Thr Ala Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser 
        835                 840                 845             


Thr Leu Ala Arg Leu Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln 
    850                 855                 860                 


Tyr Ala Ser Val Phe Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys 
865                 870                 875                 880 


Phe Asn Gln Tyr Ile Val Cys Leu Ala His His Val Ile Ala Met Trp 
                885                 890                 895     


Phe Ile Arg Cys Arg Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile 
            900                 905                 910         


Thr Lys Gly Leu Arg Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro 
        915                 920                 925             


Glu Lys Asp Ser Phe Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro 
    930                 935                 940                 


Lys Ser Leu Arg Ile Ala Arg Pro Pro Lys Gln Gly Leu Asn Asn Ser 
945                 950                 955                 960 


Pro Pro Val Lys Glu Phe Lys Glu Ser Ser Ala Ala Glu Ala Phe Arg 
                965                 970                 975     


Cys Arg Ser Ile Ser Val Ser Glu His Val Val Arg Ser Arg Ile Gln 
            980                 985                 990         


Thr Ser Leu Thr Ser Ala Ser Leu  Gly Ser Ala Asp Glu  Asn Ser Val 
        995                 1000                 1005             


Ala Gln  Ala Asp Asp Ser Leu  Lys Asn Leu His Leu  Glu Leu Thr 
    1010                 1015                 1020             


Glu Thr  Cys Leu Asp Met Met  Ala Arg Tyr Val Phe  Ser Asn Phe 
    1025                 1030                 1035             


Thr Ala  Val Pro Lys Arg Ser  Pro Val Gly Glu Phe  Leu Leu Ala 
    1040                 1045                 1050             


Gly Gly  Arg Thr Lys Thr Trp  Leu Val Gly Asn Lys  Leu Val Thr 
    1055                 1060                 1065             


Val Thr  Thr Ser Val Gly Thr  Gly Thr Arg Ser Leu  Leu Gly Leu 
    1070                 1075                 1080             


Asp Ser  Gly Glu Leu Gln Ser  Gly Pro Glu Ser Ser  Ser Ser Pro 
    1085                 1090                 1095             


Gly Val  His Val Arg Gln Thr  Lys Glu Ala Pro Ala  Lys Leu Glu 
    1100                 1105                 1110             


Ser Gln  Ala Gly Gln Gln Val  Ser Arg Gly Ala Arg  Asp Arg Val 
    1115                 1120                 1125             


Arg Ser  Met Ser Gly Gly His  Gly Leu Arg Val Gly  Ala Leu Asp 
    1130                 1135                 1140             


Val Pro  Ala Ser Gln Phe Leu  Gly Ser Ala Thr Ser  Pro Gly Pro 
    1145                 1150                 1155             


Arg Thr  Ala Pro Ala Ala Lys  Pro Glu Lys Ala Ser  Ala Gly Thr 
    1160                 1165                 1170             


Arg Val  Pro Val Gln Glu Lys  Thr Asn Leu Ala Ala  Tyr Val Pro 
    1175                 1180                 1185             


Leu Leu  Thr Gln Gly Trp Ala  Glu Ile Leu Val Arg  Arg Pro Thr 
    1190                 1195                 1200             


Gly Asn  Thr Ser Trp Leu Met  Ser Leu Glu Asn Pro  Leu Ser Pro 
    1205                 1210                 1215             


Phe Ser  Ser Asp Ile Asn Asn  Met Pro Leu Gln Glu  Leu Ser Asn 
    1220                 1225                 1230             


Ala Leu  Met Ala Ala Glu Arg  Phe Lys Glu His Arg  Asp Thr Ala 
    1235                 1240                 1245             


Leu Tyr  Lys Ser Leu Ser Val  Pro Ala Ala Ser Thr  Ala Lys Pro 
    1250                 1255                 1260             


Pro Pro  Leu Pro Arg Ser Asn  Thr Val Ala Ser Phe  Ser Ser Leu 
    1265                 1270                 1275             


Tyr Gln  Ser Ser Cys Gln Gly  Gln Leu His Arg Ser  Val Ser Trp 
    1280                 1285                 1290             


Ala Asp  Ser Ala Val Val Met  Glu Glu Gly Ser Pro  Gly Glu Val 
    1295                 1300                 1305             


Pro Val  Leu Val Glu Pro Pro  Gly Leu Glu Asp Val  Glu Ala Ala 
    1310                 1315                 1320             


Leu Gly  Met Asp Arg Arg Thr  Asp Ala Tyr Ser Arg  Ser Ser Ser 
    1325                 1330                 1335             


Val Ser  Ser Gln Glu Glu Lys  Ser Leu His Ala Glu  Glu Leu Val 
    1340                 1345                 1350             


Gly Arg  Gly Ile Pro Ile Glu  Arg Val Val Ser Ser  Glu Gly Gly 
    1355                 1360                 1365             


Arg Pro  Ser Val Asp Leu Ser  Phe Gln Pro Ser Gln  Pro Leu Ser 
    1370                 1375                 1380             


Lys Ser  Ser Ser Ser Pro Glu  Leu Gln Thr Leu Gln  Asp Ile Leu 
    1385                 1390                 1395             


Gly Asp  Pro Gly Asp Lys Ala  Asp Val Gly Arg Leu  Ser Pro Glu 
    1400                 1405                 1410             


Val Lys  Ala Arg Ser Gln Ser  Gly Thr Leu Asp Gly  Glu Ser Ala 
    1415                 1420                 1425             


Ala Trp  Ser Ala Ser Gly Glu  Asp Ser Arg Gly Gln  Pro Glu Gly 
    1430                 1435                 1440             


Pro Leu  Pro Ser Ser Ser Pro  Arg Ser Pro Ser Gly  Leu Arg Pro 
    1445                 1450                 1455             


Arg Gly  Tyr Thr Ile Ser Asp  Ser Ala Pro Ser Arg  Arg Gly Lys 
    1460                 1465                 1470             


Arg Val  Glu Arg Asp Ala Leu  Lys Ser Arg Ala Thr  Ala Ser Asn 
    1475                 1480                 1485             


Ala Glu  Lys Val Pro Gly Ile  Asn Pro Ser Phe Val  Phe Leu Gln 
    1490                 1495                 1500             


Leu Tyr  His Ser Pro Phe Phe  Gly Asp Glu Ser Asn  Lys Pro Ile 
    1505                 1510                 1515             


Leu Leu  Pro Asn Glu Ser Gln  Ser Phe Glu Arg Ser  Val Gln Leu 
    1520                 1525                 1530             


Leu Asp  Gln Ile Pro Ser Tyr  Asp Thr His Lys Ile  Ala Val Leu 
    1535                 1540                 1545             


Tyr Val  Gly Glu Gly Gln Ser  Asn Ser Glu Leu Ala  Ile Leu Ser 
    1550                 1555                 1560             


Asn Glu  His Gly Ser Tyr Arg  Tyr Thr Glu Phe Leu  Thr Gly Leu 
    1565                 1570                 1575             


Gly Arg  Leu Ile Glu Leu Lys  Asp Cys Gln Pro Asp  Lys Val Tyr 
    1580                 1585                 1590             


Leu Gly  Gly Leu Asp Val Cys  Gly Glu Asp Gly Gln  Phe Thr Tyr 
    1595                 1600                 1605             


Cys Trp  His Asp Asp Ile Met  Gln Ala Val Phe His  Ile Ala Thr 
    1610                 1615                 1620             


Leu Met  Pro Thr Lys Asp Val  Asp Lys His Arg Cys  Asp Lys Lys 
    1625                 1630                 1635             


Arg His  Leu Gly Asn Asp Phe  Val Ser Ile Val Tyr  Asn Asp Ser 
    1640                 1645                 1650             


Gly Glu  Asp Phe Lys Leu Gly  Thr Ile Lys Gly Gln  Phe Asn Phe 
    1655                 1660                 1665             


Val His  Val Ile Val Thr Pro  Leu Asp Tyr Glu Cys  Asn Leu Val 
    1670                 1675                 1680             


Ser Leu  Gln Cys Arg Lys Asp  Met Glu Gly Leu Val  Asp Thr Ser 
    1685                 1690                 1695             


Val Ala  Lys Ile Val Ser Asp  Arg Asn Leu Pro Phe  Val Ala Arg 
    1700                 1705                 1710             


Gln Met  Ala Leu His Ala Asn  Met Ala Ser Gln Val  His His Ser 
    1715                 1720                 1725             


Arg Ser  Asn Pro Thr Asp Ile  Tyr Pro Ser Lys Trp  Ile Ala Arg 
    1730                 1735                 1740             


Leu Arg  His Ile Lys Arg Leu  Arg Gln Arg Ile Cys  Glu Glu Ala 
    1745                 1750                 1755             


Ala Tyr  Ser Asn Pro Ser Leu  Pro Leu Val His Pro  Pro Ser His 
    1760                 1765                 1770             


Ser Lys  Ala Pro Ala Gln Thr  Pro Ala Glu Pro Thr  Pro Gly Tyr 
    1775                 1780                 1785             


Glu Val  Gly Gln Arg Lys Arg  Leu Ile Ser Ser Val  Glu Asp Phe 
    1790                 1795                 1800             


Thr Glu  Phe Val 
    1805         


<210> 229
<211> 1164
<212> PRT
<213> Homo sapiens

<400> 229
Met Ala Gln Gln Ala Asn Val Gly Glu Leu Leu Ala Met Leu Asp Ser 
1               5                   10                  15      


Pro Met Leu Gly Val Arg Asp Asp Val Thr Ala Val Phe Lys Glu Asn 
            20                  25                  30          


Leu Asn Ser Asp Arg Gly Pro Met Leu Val Asn Thr Leu Val Asp Tyr 
        35                  40                  45              


Tyr Leu Glu Thr Ser Ser Gln Pro Ala Leu His Ile Leu Thr Thr Leu 
    50                  55                  60                  


Gln Glu Pro His Asp Lys His Leu Leu Asp Arg Ile Asn Glu Tyr Val 
65                  70                  75                  80  


Gly Lys Ala Ala Thr Arg Leu Ser Ile Leu Ser Leu Leu Gly His Val 
                85                  90                  95      


Ile Arg Leu Gln Pro Ser Trp Lys His Lys Leu Ser Gln Ala Pro Leu 
            100                 105                 110         


Leu Pro Ser Leu Leu Lys Cys Leu Lys Met Asp Thr Asp Val Val Val 
        115                 120                 125             


Leu Thr Thr Gly Val Leu Val Leu Ile Thr Met Leu Pro Met Ile Pro 
    130                 135                 140                 


Gln Ser Gly Lys Gln His Leu Leu Asp Phe Phe Asp Ile Phe Gly Arg 
145                 150                 155                 160 


Leu Ser Ser Trp Cys Leu Lys Lys Pro Gly His Val Ala Glu Val Tyr 
                165                 170                 175     


Leu Val His Leu His Ala Ser Val Tyr Ala Leu Phe His Arg Leu Tyr 
            180                 185                 190         


Gly Met Tyr Pro Cys Asn Phe Val Ser Phe Leu Arg Ser His Tyr Ser 
        195                 200                 205             


Met Lys Glu Asn Leu Glu Thr Phe Glu Glu Val Val Lys Pro Met Met 
    210                 215                 220                 


Glu His Val Arg Ile His Pro Glu Leu Val Thr Gly Ser Lys Asp His 
225                 230                 235                 240 


Glu Leu Asp Pro Arg Arg Trp Lys Arg Leu Glu Thr His Asp Val Val 
                245                 250                 255     


Ile Glu Cys Ala Lys Ile Ser Leu Asp Pro Thr Glu Ala Ser Tyr Glu 
            260                 265                 270         


Asp Gly Tyr Ser Val Ser His Gln Ile Ser Ala Arg Phe Pro His Arg 
        275                 280                 285             


Ser Ala Asp Val Thr Thr Ser Pro Tyr Ala Asp Thr Gln Asn Ser Tyr 
    290                 295                 300                 


Gly Cys Ala Thr Ser Thr Pro Tyr Ser Thr Ser Arg Leu Met Leu Leu 
305                 310                 315                 320 


Asn Met Pro Gly Gln Leu Pro Gln Thr Leu Ser Ser Pro Ser Thr Arg 
                325                 330                 335     


Leu Ile Thr Glu Pro Pro Gln Ala Thr Leu Trp Ser Pro Ser Met Val 
            340                 345                 350         


Cys Gly Met Thr Thr Pro Pro Thr Ser Pro Gly Asn Val Pro Pro Asp 
        355                 360                 365             


Leu Ser His Pro Tyr Ser Lys Val Phe Gly Thr Thr Ala Gly Gly Lys 
    370                 375                 380                 


Gly Thr Pro Leu Gly Thr Pro Ala Thr Ser Pro Pro Pro Ala Pro Leu 
385                 390                 395                 400 


Cys His Ser Asp Asp Tyr Val His Ile Ser Leu Pro Gln Ala Thr Val 
                405                 410                 415     


Thr Pro Pro Arg Lys Glu Glu Arg Met Asp Ser Ala Arg Pro Cys Leu 
            420                 425                 430         


His Arg Gln His His Leu Leu Asn Asp Arg Gly Ser Glu Glu Pro Pro 
        435                 440                 445             


Gly Ser Lys Gly Ser Val Thr Leu Ser Asp Leu Pro Gly Phe Leu Gly 
    450                 455                 460                 


Asp Leu Ala Ser Glu Glu Asp Ser Ile Glu Lys Asp Lys Glu Glu Ala 
465                 470                 475                 480 


Ala Ile Ser Arg Glu Leu Ser Glu Ile Thr Thr Ala Glu Ala Glu Pro 
                485                 490                 495     


Val Val Pro Arg Gly Gly Phe Asp Ser Pro Phe Tyr Arg Asp Ser Leu 
            500                 505                 510         


Pro Gly Ser Gln Arg Lys Thr His Ser Ala Ala Ser Ser Ser Gln Gly 
        515                 520                 525             


Ala Ser Val Asn Pro Glu Pro Leu His Ser Ser Leu Asp Lys Leu Gly 
    530                 535                 540                 


Pro Asp Thr Pro Lys Gln Ala Phe Thr Pro Ile Asp Leu Pro Cys Gly 
545                 550                 555                 560 


Ser Ala Asp Glu Ser Pro Ala Gly Asp Arg Glu Cys Gln Thr Ser Leu 
                565                 570                 575     


Glu Thr Ser Ile Phe Thr Pro Ser Pro Cys Lys Ile Pro Pro Pro Thr 
            580                 585                 590         


Arg Val Gly Phe Gly Ser Gly Gln Pro Pro Pro Tyr Asp His Leu Phe 
        595                 600                 605             


Glu Val Ala Leu Pro Lys Thr Ala His His Phe Val Ile Arg Lys Thr 
    610                 615                 620                 


Glu Glu Leu Leu Lys Lys Ala Lys Gly Asn Thr Glu Glu Asp Gly Val 
625                 630                 635                 640 


Pro Ser Thr Ser Pro Met Glu Val Leu Asp Arg Leu Ile Gln Gln Gly 
                645                 650                 655     


Ala Asp Ala His Ser Lys Glu Leu Asn Lys Leu Pro Leu Pro Ser Lys 
            660                 665                 670         


Ser Val Asp Trp Thr His Phe Gly Gly Ser Pro Pro Ser Asp Glu Ile 
        675                 680                 685             


Arg Thr Leu Arg Asp Gln Leu Leu Leu Leu His Asn Gln Leu Leu Tyr 
    690                 695                 700                 


Glu Arg Phe Lys Arg Gln Gln His Ala Leu Arg Asn Arg Arg Leu Leu 
705                 710                 715                 720 


Arg Lys Val Ile Lys Ala Ala Ala Leu Glu Glu His Asn Ala Ala Met 
                725                 730                 735     


Lys Asp Gln Leu Lys Leu Gln Glu Lys Asp Ile Gln Met Trp Lys Val 
            740                 745                 750         


Ser Leu Gln Lys Glu Gln Ala Arg Tyr Asn Gln Leu Gln Glu Gln Arg 
        755                 760                 765             


Asp Thr Met Val Thr Lys Leu His Ser Gln Ile Arg Gln Leu Gln His 
    770                 775                 780                 


Asp Arg Glu Glu Phe Tyr Asn Gln Ser Gln Glu Leu Gln Thr Lys Leu 
785                 790                 795                 800 


Glu Asp Cys Arg Asn Met Ile Ala Glu Leu Arg Ile Glu Leu Lys Lys 
                805                 810                 815     


Ala Asn Asn Lys Val Cys His Thr Glu Leu Leu Leu Ser Gln Val Ser 
            820                 825                 830         


Gln Lys Leu Ser Asn Ser Glu Ser Val Gln Gln Gln Met Glu Phe Leu 
        835                 840                 845             


Asn Arg Gln Leu Leu Val Leu Gly Glu Val Asn Glu Leu Tyr Leu Glu 
    850                 855                 860                 


Gln Leu Gln Asn Lys His Ser Asp Thr Thr Lys Glu Val Glu Met Met 
865                 870                 875                 880 


Lys Ala Ala Tyr Arg Lys Glu Leu Glu Lys Asn Arg Ser His Val Leu 
                885                 890                 895     


Gln Gln Thr Gln Arg Leu Asp Thr Ser Gln Lys Arg Ile Leu Glu Leu 
            900                 905                 910         


Glu Ser His Leu Ala Lys Lys Asp His Leu Leu Leu Glu Gln Lys Lys 
        915                 920                 925             


Tyr Leu Glu Asp Val Lys Leu Gln Ala Arg Gly Gln Leu Gln Ala Ala 
    930                 935                 940                 


Glu Ser Arg Tyr Glu Ala Gln Lys Arg Ile Thr Gln Val Phe Glu Leu 
945                 950                 955                 960 


Glu Ile Leu Asp Leu Tyr Gly Arg Leu Glu Lys Asp Gly Leu Leu Lys 
                965                 970                 975     


Lys Leu Glu Glu Glu Lys Ala Glu Ala Ala Glu Ala Ala Glu Glu Arg 
            980                 985                 990         


Leu Asp Cys Cys Asn Asp Gly Cys  Ser Asp Ser Met Val  Gly His Asn 
        995                 1000                 1005             


Glu Glu  Ala Ser Gly His Asn  Gly Glu Thr Lys Thr  Pro Arg Pro 
    1010                 1015                 1020             


Ser Ser  Ala Arg Gly Ser Ser  Gly Ser Arg Gly Gly  Gly Gly Ser 
    1025                 1030                 1035             


Ser Ser  Ser Ser Ser Glu Leu  Ser Thr Pro Glu Lys  Pro Pro His 
    1040                 1045                 1050             


Gln Arg  Ala Gly Pro Phe Ser  Ser Arg Trp Glu Thr  Thr Met Gly 
    1055                 1060                 1065             


Glu Ala  Ser Ala Ser Ile Pro  Thr Thr Val Gly Ser  Leu Pro Ser 
    1070                 1075                 1080             


Ser Lys  Ser Phe Leu Gly Met  Lys Ala Arg Glu Leu  Phe Arg Asn 
    1085                 1090                 1095             


Lys Ser  Glu Ser Gln Cys Asp  Glu Asp Gly Met Thr  Ser Ser Leu 
    1100                 1105                 1110             


Ser Glu  Ser Leu Lys Thr Glu  Leu Gly Lys Asp Leu  Gly Val Glu 
    1115                 1120                 1125             


Ala Lys  Ile Pro Leu Asn Leu  Asp Gly Pro His Pro  Ser Pro Pro 
    1130                 1135                 1140             


Thr Pro  Asp Ser Val Gly Gln  Leu His Ile Met Asp  Tyr Asn Glu 
    1145                 1150                 1155             


Thr His  His Glu His Ser 
    1160                 


<210> 230
<211> 1690
<212> PRT
<213> Homo sapiens

<400> 230
Met Ala Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn 
1               5                   10                  15      


Ser Arg Glu Met Ser Arg Asp Ser Lys Cys Ile Ile Gln Met Ser Gly 
            20                  25                  30          


Ser Thr Thr Thr Ile Val Asn Pro Lys Gln Pro Lys Glu Thr Pro Lys 
        35                  40                  45              


Ser Phe Ser Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Pro Glu Asp 
    50                  55                  60                  


Ile Asn Tyr Ala Ser Gln Lys Gln Val Tyr Arg Asp Ile Gly Glu Glu 
65                  70                  75                  80  


Met Leu Gln His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr 
                85                  90                  95      


Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Lys Gln Glu 
            100                 105                 110         


Lys Asp Gln Gln Gly Ile Ile Pro Gln Leu Cys Glu Asp Leu Phe Ser 
        115                 120                 125             


Arg Ile Asn Asp Thr Thr Asn Asp Asn Met Ser Tyr Ser Val Glu Val 
    130                 135                 140                 


Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro 
145                 150                 155                 160 


Lys Asn Lys Gly Asn Leu Arg Val Arg Glu His Pro Leu Leu Gly Pro 
                165                 170                 175     


Tyr Val Glu Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Asn Asp Ile 
            180                 185                 190         


Gln Asp Leu Met Asp Ser Gly Asn Lys Ala Arg Thr Val Ala Ala Thr 
        195                 200                 205             


Asn Met Asn Glu Thr Ser Ser Arg Ser His Ala Val Phe Asn Ile Ile 
    210                 215                 220                 


Phe Thr Gln Lys Arg His Asp Ala Glu Thr Asn Ile Thr Thr Glu Lys 
225                 230                 235                 240 


Val Ser Lys Ile Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Asp 
                245                 250                 255     


Ser Thr Gly Ala Lys Gly Thr Arg Leu Lys Glu Gly Ala Asn Ile Asn 
            260                 265                 270         


Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Glu Met 
        275                 280                 285             


Asp Ser Gly Pro Asn Lys Asn Lys Lys Lys Lys Lys Thr Asp Phe Ile 
    290                 295                 300                 


Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Arg Glu Asn Leu Gly 
305                 310                 315                 320 


Gly Asn Ser Arg Thr Ala Met Val Ala Ala Leu Ser Pro Ala Asp Ile 
                325                 330                 335     


Asn Tyr Asp Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys 
            340                 345                 350         


Gln Ile Arg Cys Asn Ala Val Ile Asn Glu Asp Pro Asn Asn Lys Leu 
        355                 360                 365             


Ile Arg Glu Leu Lys Asp Glu Val Thr Arg Leu Arg Asp Leu Leu Tyr 
    370                 375                 380                 


Ala Gln Gly Leu Gly Asp Ile Thr Asp Met Thr Asn Ala Leu Val Gly 
385                 390                 395                 400 


Met Ser Pro Ser Ser Ser Leu Ser Ala Leu Ser Ser Arg Ala Ala Ser 
                405                 410                 415     


Val Ser Ser Leu His Glu Arg Ile Leu Phe Ala Pro Gly Ser Glu Glu 
            420                 425                 430         


Ala Ile Glu Arg Leu Lys Glu Thr Glu Lys Ile Ile Ala Glu Leu Asn 
        435                 440                 445             


Glu Thr Trp Glu Glu Lys Leu Arg Arg Thr Glu Ala Ile Arg Met Glu 
    450                 455                 460                 


Arg Glu Ala Leu Leu Ala Glu Met Gly Val Ala Met Arg Glu Asp Gly 
465                 470                 475                 480 


Gly Thr Leu Gly Val Phe Ser Pro Lys Lys Thr Pro His Leu Val Asn 
                485                 490                 495     


Leu Asn Glu Asp Pro Leu Met Ser Glu Cys Leu Leu Tyr Tyr Ile Lys 
            500                 505                 510         


Asp Gly Ile Thr Arg Val Gly Arg Glu Asp Gly Glu Arg Arg Gln Asp 
        515                 520                 525             


Ile Val Leu Ser Gly His Phe Ile Lys Glu Glu His Cys Val Phe Arg 
    530                 535                 540                 


Ser Asp Ser Arg Gly Gly Ser Glu Ala Val Val Thr Leu Glu Pro Cys 
545                 550                 555                 560 


Glu Gly Ala Asp Thr Tyr Val Asn Gly Lys Lys Val Thr Glu Pro Ser 
                565                 570                 575     


Ile Leu Arg Ser Gly Asn Arg Ile Ile Met Gly Lys Ser His Val Phe 
            580                 585                 590         


Arg Phe Asn His Pro Glu Gln Ala Arg Gln Glu Arg Glu Arg Thr Pro 
        595                 600                 605             


Cys Ala Glu Thr Pro Ala Glu Pro Val Asp Trp Ala Phe Ala Gln Arg 
    610                 615                 620                 


Glu Leu Leu Glu Lys Gln Gly Ile Asp Met Lys Gln Glu Met Glu Gln 
625                 630                 635                 640 


Arg Leu Gln Glu Leu Glu Asp Gln Tyr Arg Arg Glu Arg Glu Glu Ala 
                645                 650                 655     


Thr Tyr Leu Leu Glu Gln Gln Arg Leu Asp Tyr Glu Ser Lys Leu Glu 
            660                 665                 670         


Ala Leu Gln Lys Gln Met Asp Ser Arg Tyr Tyr Pro Glu Val Asn Glu 
        675                 680                 685             


Glu Glu Glu Glu Pro Glu Asp Glu Val Gln Trp Thr Glu Arg Glu Cys 
    690                 695                 700                 


Glu Leu Ala Leu Trp Ala Phe Arg Lys Trp Lys Trp Tyr Gln Phe Thr 
705                 710                 715                 720 


Ser Leu Arg Asp Leu Leu Trp Gly Asn Ala Ile Phe Leu Lys Glu Ala 
                725                 730                 735     


Asn Ala Ile Ser Val Glu Leu Lys Lys Lys Val Gln Phe Gln Phe Val 
            740                 745                 750         


Leu Leu Thr Asp Thr Leu Tyr Ser Pro Leu Pro Pro Asp Leu Leu Pro 
        755                 760                 765             


Pro Glu Ala Ala Lys Asp Arg Glu Thr Arg Pro Phe Pro Arg Thr Ile 
    770                 775                 780                 


Val Ala Val Glu Val Gln Asp Gln Lys Asn Gly Ala Thr His Tyr Trp 
785                 790                 795                 800 


Thr Leu Glu Lys Leu Arg Gln Arg Leu Asp Leu Met Arg Glu Met Tyr 
                805                 810                 815     


Asp Arg Ala Ala Glu Val Pro Ser Ser Val Ile Glu Asp Cys Asp Asn 
            820                 825                 830         


Val Val Thr Gly Gly Asp Pro Phe Tyr Asp Arg Phe Pro Trp Phe Arg 
        835                 840                 845             


Leu Val Gly Arg Ala Phe Val Tyr Leu Ser Asn Leu Leu Tyr Pro Val 
    850                 855                 860                 


Pro Leu Val His Arg Val Ala Ile Val Ser Glu Lys Gly Glu Val Lys 
865                 870                 875                 880 


Gly Phe Leu Arg Val Ala Val Gln Ala Ile Ser Ala Asp Glu Glu Ala 
                885                 890                 895     


Pro Asp Tyr Gly Ser Gly Val Arg Gln Ser Gly Thr Ala Lys Ile Ser 
            900                 905                 910         


Phe Asp Asp Gln His Phe Glu Lys Phe Gln Ser Glu Ser Cys Pro Val 
        915                 920                 925             


Val Gly Met Ser Arg Ser Gly Thr Ser Gln Glu Glu Leu Arg Ile Val 
    930                 935                 940                 


Glu Gly Gln Gly Gln Gly Ala Asp Val Gly Pro Ser Ala Asp Glu Val 
945                 950                 955                 960 


Asn Asn Asn Thr Cys Ser Ala Val Pro Pro Glu Gly Leu Leu Leu Asp 
                965                 970                 975     


Ser Ser Glu Lys Ala Ala Leu Asp Gly Pro Leu Asp Ala Ala Leu Asp 
            980                 985                 990         


His Leu Arg Leu Gly Asn Thr Phe  Thr Phe Arg Val Thr  Val Leu Gln 
        995                 1000                 1005             


Ala Ser  Ser Ile Ser Ala Glu  Tyr Ala Asp Ile Phe  Cys Gln Phe 
    1010                 1015                 1020             


Asn Phe  Ile His Arg His Asp  Glu Ala Phe Ser Thr  Glu Pro Leu 
    1025                 1030                 1035             


Lys Asn  Thr Gly Arg Gly Pro  Pro Leu Gly Phe Tyr  His Val Gln 
    1040                 1045                 1050             


Asn Ile  Ala Val Glu Val Thr  Lys Ser Phe Ile Glu  Tyr Ile Lys 
    1055                 1060                 1065             


Ser Gln  Pro Ile Val Phe Glu  Val Phe Gly His Tyr  Gln Gln His 
    1070                 1075                 1080             


Pro Phe  Pro Pro Leu Cys Lys  Asp Val Leu Ser Pro  Leu Arg Pro 
    1085                 1090                 1095             


Ser Arg  Arg His Phe Pro Arg  Val Met Pro Leu Ser  Lys Pro Val 
    1100                 1105                 1110             


Pro Ala  Thr Lys Leu Ser Thr  Leu Thr Arg Pro Cys  Pro Gly Pro 
    1115                 1120                 1125             


Cys His  Cys Lys Tyr Asp Leu  Leu Val Tyr Phe Glu  Ile Cys Glu 
    1130                 1135                 1140             


Leu Glu  Ala Asn Gly Asp Tyr  Ile Pro Ala Val Val  Asp His Arg 
    1145                 1150                 1155             


Gly Gly  Met Pro Cys Met Gly  Thr Phe Leu Leu His  Gln Gly Ile 
    1160                 1165                 1170             


Gln Arg  Arg Ile Thr Val Thr  Leu Leu His Glu Thr  Gly Ser His 
    1175                 1180                 1185             


Ile Arg  Trp Lys Glu Val Arg  Glu Leu Val Val Gly  Arg Ile Arg 
    1190                 1195                 1200             


Asn Thr  Pro Glu Thr Asp Glu  Ser Leu Ile Asp Pro  Asn Ile Leu 
    1205                 1210                 1215             


Ser Leu  Asn Ile Leu Ser Ser  Gly Tyr Ile His Pro  Ala Gln Asp 
    1220                 1225                 1230             


Asp Arg  Thr Phe Tyr Gln Phe  Glu Ala Ala Trp Asp  Ser Ser Met 
    1235                 1240                 1245             


His Asn  Ser Leu Leu Leu Asn  Arg Val Thr Pro Tyr  Arg Glu Lys 
    1250                 1255                 1260             


Ile Tyr  Met Thr Leu Ser Ala  Tyr Ile Glu Met Glu  Asn Cys Thr 
    1265                 1270                 1275             


Gln Pro  Ala Val Val Thr Lys  Asp Phe Cys Met Val  Phe Tyr Ser 
    1280                 1285                 1290             


Arg Asp  Ala Lys Leu Pro Ala  Ser Arg Ser Ile Arg  Asn Leu Phe 
    1295                 1300                 1305             


Gly Ser  Gly Ser Leu Arg Ala  Ser Glu Ser Asn Arg  Val Thr Gly 
    1310                 1315                 1320             


Val Tyr  Glu Leu Ser Leu Cys  His Val Ala Asp Ala  Gly Ser Pro 
    1325                 1330                 1335             


Gly Met  Gln Arg Arg Arg Arg  Arg Val Leu Asp Thr  Ser Val Ala 
    1340                 1345                 1350             


Tyr Val  Arg Gly Glu Glu Asn  Leu Ala Gly Trp Arg  Pro Arg Ser 
    1355                 1360                 1365             


Asp Ser  Leu Ile Leu Asp His  Gln Trp Glu Leu Glu  Lys Leu Ser 
    1370                 1375                 1380             


Leu Leu  Gln Glu Val Glu Lys  Thr Arg His Tyr Leu  Leu Leu Arg 
    1385                 1390                 1395             


Glu Lys  Leu Glu Thr Ala Gln  Arg Pro Val Pro Glu  Ala Leu Ser 
    1400                 1405                 1410             


Pro Ala  Phe Ser Glu Asp Ser  Glu Ser His Gly Ser  Ser Ser Ala 
    1415                 1420                 1425             


Ser Ser  Pro Leu Ser Ala Glu  Gly Arg Pro Ser Pro  Leu Glu Ala 
    1430                 1435                 1440             


Pro Asn  Glu Arg Gln Arg Glu  Leu Ala Val Lys Cys  Leu Arg Leu 
    1445                 1450                 1455             


Leu Thr  His Thr Phe Asn Arg  Glu Tyr Thr His Ser  His Val Cys 
    1460                 1465                 1470             


Val Ser  Ala Ser Glu Ser Lys  Leu Ser Glu Met Ser  Val Thr Leu 
    1475                 1480                 1485             


Leu Arg  Asp Pro Ser Met Ser  Pro Leu Gly Val Ala  Thr Leu Thr 
    1490                 1495                 1500             


Pro Ser  Ser Thr Cys Pro Ser  Leu Val Glu Gly Arg  Tyr Gly Ala 
    1505                 1510                 1515             


Thr Asp  Leu Arg Thr Pro Gln  Pro Cys Ser Arg Pro  Ala Ser Pro 
    1520                 1525                 1530             


Glu Pro  Glu Leu Leu Pro Glu  Ala Asp Ser Lys Lys  Leu Pro Ser 
    1535                 1540                 1545             


Pro Ala  Arg Ala Thr Glu Thr  Asp Lys Glu Pro Gln  Arg Leu Leu 
    1550                 1555                 1560             


Val Pro  Asp Ile Gln Glu Ile  Arg Val Ser Pro Ile  Val Ser Lys 
    1565                 1570                 1575             


Lys Gly  Tyr Leu His Phe Leu  Glu Pro His Thr Ser  Gly Trp Ala 
    1580                 1585                 1590             


Arg Arg  Phe Val Val Val Arg  Arg Pro Tyr Ala Tyr  Met Tyr Asn 
    1595                 1600                 1605             


Ser Asp  Lys Asp Thr Val Glu  Arg Phe Val Leu Asn  Leu Ala Thr 
    1610                 1615                 1620             


Ala Gln  Val Glu Tyr Ser Glu  Asp Gln Gln Ala Met  Leu Lys Thr 
    1625                 1630                 1635             


Pro Asn  Thr Phe Ala Val Cys  Thr Glu His Arg Gly  Ile Leu Leu 
    1640                 1645                 1650             


Gln Ala  Ala Ser Asp Lys Asp  Met His Asp Trp Leu  Tyr Ala Phe 
    1655                 1660                 1665             


Asn Pro  Leu Leu Ala Gly Thr  Ile Arg Ser Lys Leu  Ser Arg Arg 
    1670                 1675                 1680             


Arg Ser  Ala Gln Met Arg Val  
    1685                 1690 


<210> 231
<211> 864
<212> PRT
<213> Homo sapiens

<400> 231
Met Gly Asn Arg Gly Met Glu Asp Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Ile Gly Gln Asn Ala Asp Leu Asp Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Asn Ala Thr Thr Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Glu Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
            100                 105                 110         


Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Val Asp Leu Pro Gly Met Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Phe Gln Ile Arg Asp Met Leu 
145                 150                 155                 160 


Met Gln Phe Val Thr Lys Glu Asn Cys Leu Ile Leu Ala Val Ser Pro 
                165                 170                 175     


Ala Asn Ser Asp Leu Ala Asn Ser Asp Ala Leu Lys Val Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Gln Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Thr Ala Ala Leu Ala Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ser Tyr Arg His Leu Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro Tyr Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Gly Leu Arg Asn Lys Leu Gln Ser Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp 
305                 310                 315                 320 


Asp Pro Ala Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Ile Asp 
            340                 345                 350         


Thr Tyr Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Thr Ile Val Lys Lys Gln 
                405                 410                 415     


Val Lys Lys Ile Arg Glu Pro Cys Leu Lys Cys Val Asp Met Val Ile 
            420                 425                 430         


Ser Glu Leu Ile Ser Thr Val Arg Gln Cys Thr Lys Lys Leu Gln Gln 
        435                 440                 445             


Tyr Pro Arg Leu Arg Glu Glu Met Glu Arg Ile Val Thr Thr His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Arg Thr Lys Glu Gln Val Met Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Glu Leu Ala Tyr Met Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Asn Gln Met Asn Lys Lys Lys Thr Ser 
            500                 505                 510         


Gly Asn Gln Asp Glu Ile Leu Val Ile Arg Lys Gly Trp Leu Thr Ile 
        515                 520                 525             


Asn Asn Ile Gly Ile Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val 
    530                 535                 540                 


Leu Thr Ala Glu Asn Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu 
545                 550                 555                 560 


Lys Lys Tyr Met Leu Ser Val Asp Asn Leu Lys Leu Arg Asp Val Glu 
                565                 570                 575     


Lys Gly Phe Met Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu 
            580                 585                 590         


Gln Arg Asn Val Tyr Lys Asp Tyr Arg Gln Leu Glu Leu Ala Cys Glu 
        595                 600                 605             


Thr Gln Glu Glu Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly 
    610                 615                 620                 


Val Tyr Pro Glu Arg Val Gly Asp Lys Glu Lys Ala Ser Glu Thr Glu 
625                 630                 635                 640 


Glu Asn Gly Ser Asp Ser Phe Met His Ser Met Asp Pro Gln Leu Glu 
                645                 650                 655     


Arg Gln Val Glu Thr Ile Arg Asn Leu Val Asp Ser Tyr Met Ala Ile 
            660                 665                 670         


Val Asn Lys Thr Val Arg Asp Leu Met Pro Lys Thr Ile Met His Leu 
        675                 680                 685             


Met Ile Asn Asn Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ala Asn 
    690                 695                 700                 


Leu Tyr Ser Cys Gly Asp Gln Asn Thr Leu Met Glu Glu Ser Ala Glu 
705                 710                 715                 720 


Gln Ala Gln Arg Arg Asp Glu Met Leu Arg Met Tyr His Ala Leu Lys 
                725                 730                 735     


Glu Ala Leu Ser Ile Ile Gly Asp Ile Asn Thr Thr Thr Val Ser Thr 
            740                 745                 750         


Pro Met Pro Pro Pro Val Asp Asp Ser Trp Leu Gln Val Gln Ser Val 
        755                 760                 765             


Pro Ala Gly Arg Arg Ser Pro Thr Ser Ser Pro Thr Pro Gln Arg Arg 
    770                 775                 780                 


Ala Pro Ala Val Pro Pro Ala Arg Pro Gly Ser Arg Gly Pro Ala Pro 
785                 790                 795                 800 


Gly Pro Pro Pro Ala Gly Ser Ala Leu Gly Gly Ala Pro Pro Val Pro 
                805                 810                 815     


Ser Arg Pro Gly Ala Ser Pro Asp Pro Phe Gly Pro Pro Pro Gln Val 
            820                 825                 830         


Pro Ser Arg Pro Asn Arg Ala Pro Pro Gly Val Pro Ser Arg Ser Gly 
        835                 840                 845             


Gln Ala Ser Pro Ser Arg Pro Glu Ser Pro Arg Pro Pro Phe Asp Leu 
    850                 855                 860                 


<210> 232
<211> 1731
<212> PRT
<213> Homo sapiens

<400> 232
Met Asp Gly Pro Gly Ala Ser Ala Val Val Val Arg Val Gly Ile Pro 
1               5                   10                  15      


Asp Leu Gln Gln Thr Lys Cys Leu Arg Leu Asp Pro Ala Ala Pro Val 
            20                  25                  30          


Trp Ala Ala Lys Gln Arg Val Leu Cys Ala Leu Asn His Ser Leu Gln 
        35                  40                  45              


Asp Ala Leu Asn Tyr Gly Leu Phe Gln Pro Pro Ser Arg Gly Arg Ala 
    50                  55                  60                  


Gly Lys Phe Leu Asp Glu Glu Arg Leu Leu Gln Glu Tyr Pro Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Pro Leu Pro Tyr Leu Glu Phe Arg Tyr Lys Arg Arg Val 
                85                  90                  95      


Tyr Ala Gln Asn Leu Ile Asp Asp Lys Gln Phe Ala Lys Leu His Thr 
            100                 105                 110         


Lys Ala Asn Leu Lys Lys Phe Met Asp Tyr Val Gln Leu His Ser Thr 
        115                 120                 125             


Asp Lys Val Ala Arg Leu Leu Asp Lys Gly Leu Asp Pro Asn Phe His 
    130                 135                 140                 


Asp Pro Asp Ser Gly Glu Cys Pro Leu Ser Leu Ala Ala Gln Leu Asp 
145                 150                 155                 160 


Asn Ala Thr Asp Leu Leu Lys Val Leu Lys Asn Gly Gly Ala His Leu 
                165                 170                 175     


Asp Phe Arg Thr Arg Asp Gly Leu Thr Ala Val His Cys Ala Thr Arg 
            180                 185                 190         


Gln Arg Asn Ala Ala Ala Leu Thr Thr Leu Leu Asp Leu Gly Ala Ser 
        195                 200                 205             


Pro Asp Tyr Lys Asp Ser Arg Gly Leu Thr Pro Leu Tyr His Ser Ala 
    210                 215                 220                 


Leu Gly Gly Gly Asp Ala Leu Cys Cys Glu Leu Leu Leu His Asp His 
225                 230                 235                 240 


Ala Gln Leu Gly Ile Thr Asp Glu Asn Gly Trp Gln Glu Ile His Gln 
                245                 250                 255     


Ala Cys Arg Phe Gly His Val Gln His Leu Glu His Leu Leu Phe Tyr 
            260                 265                 270         


Gly Ala Asp Met Gly Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His 
        275                 280                 285             


Ile Cys Ala Leu Tyr Asn Gln Glu Ser Cys Ala Arg Val Leu Leu Phe 
    290                 295                 300                 


Arg Gly Ala Asn Arg Asp Val Arg Asn Tyr Asn Ser Gln Thr Ala Phe 
305                 310                 315                 320 


Gln Val Ala Ile Ile Ala Gly Asn Phe Glu Leu Ala Glu Val Ile Lys 
                325                 330                 335     


Thr His Lys Asp Ser Asp Val Val Pro Phe Arg Glu Thr Pro Ser Tyr 
            340                 345                 350         


Ala Lys Arg Arg Arg Leu Ala Gly Pro Ser Gly Leu Ala Ser Pro Arg 
        355                 360                 365             


Pro Leu Gln Arg Ser Ala Ser Asp Ile Asn Leu Lys Gly Glu Ala Gln 
    370                 375                 380                 


Pro Ala Ala Ser Pro Gly Pro Ser Leu Arg Ser Leu Pro His Gln Leu 
385                 390                 395                 400 


Leu Leu Gln Arg Leu Gln Glu Glu Lys Asp Arg Asp Arg Asp Ala Asp 
                405                 410                 415     


Gln Glu Ser Asn Ile Ser Gly Pro Leu Ala Gly Arg Ala Gly Gln Ser 
            420                 425                 430         


Lys Ile Ser Pro Ser Gly Pro Gly Gly Pro Gly Pro Ala Pro Gly Pro 
        435                 440                 445             


Gly Pro Ala Pro Pro Ala Pro Pro Ala Pro Pro Pro Arg Gly Pro Lys 
    450                 455                 460                 


Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys Phe Ile Ala Val Lys 
465                 470                 475                 480 


Ala His Ser Pro Gln Gly Glu Gly Glu Ile Pro Leu His Arg Gly Glu 
                485                 490                 495     


Ala Val Lys Val Leu Ser Ile Gly Glu Gly Gly Phe Trp Glu Gly Thr 
            500                 505                 510         


Val Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp Cys Val Glu Glu Val 
        515                 520                 525             


Gln Met Arg Gln His Asp Thr Arg Pro Glu Thr Arg Glu Asp Arg Thr 
    530                 535                 540                 


Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser Tyr Asp Ser Leu Thr 
545                 550                 555                 560 


Ser His Ser Asp Tyr Val Ile Asp Asp Lys Val Ala Val Leu Gln Lys 
                565                 570                 575     


Arg Asp His Glu Gly Phe Gly Phe Val Leu Arg Gly Ala Lys Ala Glu 
            580                 585                 590         


Thr Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala Phe Pro Ala Leu Gln 
        595                 600                 605             


Tyr Leu Glu Ser Val Asp Val Glu Gly Val Ala Trp Arg Ala Gly Leu 
    610                 615                 620                 


Arg Thr Gly Asp Phe Leu Ile Glu Val Asn Gly Val Asn Val Val Lys 
625                 630                 635                 640 


Val Gly His Lys Gln Val Val Ala Leu Ile Arg Gln Gly Gly Asn Arg 
                645                 650                 655     


Leu Val Met Lys Val Val Ser Val Thr Arg Lys Pro Glu Glu Asp Gly 
            660                 665                 670         


Ala Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg Ala Pro Ser Thr Thr 
        675                 680                 685             


Leu Thr Leu Arg Ser Lys Ser Met Thr Ala Glu Leu Glu Glu Leu Ala 
    690                 695                 700                 


Ser Ile Arg Arg Arg Lys Gly Glu Lys Leu Asp Glu Met Leu Ala Ala 
705                 710                 715                 720 


Ala Ala Glu Pro Thr Leu Arg Pro Asp Ile Ala Asp Ala Asp Ser Arg 
                725                 730                 735     


Ala Ala Thr Val Lys Gln Arg Pro Thr Ser Arg Arg Ile Thr Pro Ala 
            740                 745                 750         


Glu Ile Ser Ser Leu Phe Glu Arg Gln Gly Leu Pro Gly Pro Glu Lys 
        755                 760                 765             


Leu Pro Gly Ser Leu Arg Lys Gly Ile Pro Arg Thr Lys Ser Val Gly 
    770                 775                 780                 


Glu Asp Glu Lys Leu Ala Ser Leu Leu Glu Gly Arg Phe Pro Arg Ser 
785                 790                 795                 800 


Thr Ser Met Gln Asp Pro Val Arg Glu Gly Arg Gly Ile Pro Pro Pro 
                805                 810                 815     


Pro Gln Thr Ala Pro Pro Pro Pro Pro Ala Pro Tyr Tyr Phe Asp Ser 
            820                 825                 830         


Gly Pro Pro Pro Ala Phe Ser Pro Pro Pro Pro Pro Gly Arg Ala Tyr 
        835                 840                 845             


Asp Thr Val Arg Ser Ser Phe Lys Pro Gly Leu Glu Ala Arg Leu Gly 
    850                 855                 860                 


Ala Gly Ala Ala Gly Leu Tyr Glu Pro Gly Ala Ala Leu Gly Pro Leu 
865                 870                 875                 880 


Pro Tyr Pro Glu Arg Gln Lys Arg Ala Arg Ser Met Ile Ile Leu Gln 
                885                 890                 895     


Asp Ser Ala Pro Glu Ser Gly Asp Ala Pro Arg Pro Pro Pro Ala Ala 
            900                 905                 910         


Thr Pro Pro Glu Arg Pro Lys Arg Arg Pro Arg Pro Pro Gly Pro Asp 
        915                 920                 925             


Ser Pro Tyr Ala Asn Leu Gly Ala Phe Ser Ala Ser Leu Phe Ala Pro 
    930                 935                 940                 


Ser Lys Pro Gln Arg Arg Lys Ser Pro Leu Val Lys Gln Leu Gln Val 
945                 950                 955                 960 


Glu Asp Ala Gln Glu Arg Ala Ala Leu Ala Val Gly Ser Pro Gly Pro 
                965                 970                 975     


Gly Gly Gly Ser Phe Ala Arg Glu Pro Ser Pro Thr His Arg Gly Pro 
            980                 985                 990         


Arg Pro Gly Gly Leu Asp Tyr Gly  Ala Gly Asp Gly Pro  Gly Leu Ala 
        995                 1000                 1005             


Phe Gly  Gly Pro Gly Pro Ala  Lys Asp Arg Arg Leu  Glu Glu Arg 
    1010                 1015                 1020             


Arg Arg  Ser Thr Val Phe Leu  Ser Val Gly Ala Ile  Glu Gly Ser 
    1025                 1030                 1035             


Ala Pro  Gly Ala Asp Leu Pro  Ser Leu Gln Pro Ser  Arg Ser Ile 
    1040                 1045                 1050             


Asp Glu  Arg Leu Leu Gly Thr  Gly Pro Thr Ala Gly  Arg Asp Leu 
    1055                 1060                 1065             


Leu Leu  Pro Ser Pro Val Ser  Ala Leu Lys Pro Leu  Val Ser Gly 
    1070                 1075                 1080             


Pro Ser  Leu Gly Pro Ser Gly  Ser Thr Phe Ile His  Pro Leu Thr 
    1085                 1090                 1095             


Gly Lys  Pro Leu Asp Pro Ser  Ser Pro Leu Ala Leu  Ala Leu Ala 
    1100                 1105                 1110             


Ala Arg  Glu Arg Ala Leu Ala  Ser Gln Ala Pro Ser  Arg Ser Pro 
    1115                 1120                 1125             


Thr Pro  Val His Ser Pro Asp  Ala Asp Arg Pro Gly  Pro Leu Phe 
    1130                 1135                 1140             


Val Asp  Val Gln Ala Arg Asp  Pro Glu Arg Gly Ser  Leu Ala Ser 
    1145                 1150                 1155             


Pro Ala  Phe Ser Pro Arg Ser  Pro Ala Trp Ile Pro  Val Pro Ala 
    1160                 1165                 1170             


Arg Arg  Glu Ala Glu Lys Val  Pro Arg Glu Glu Arg  Lys Ser Pro 
    1175                 1180                 1185             


Glu Asp  Lys Lys Ser Met Ile  Leu Ser Val Leu Asp  Thr Ser Leu 
    1190                 1195                 1200             


Gln Arg  Pro Ala Gly Leu Ile  Val Val His Ala Thr  Ser Asn Gly 
    1205                 1210                 1215             


Gln Glu  Pro Ser Arg Leu Gly  Gly Ala Glu Glu Glu  Arg Pro Gly 
    1220                 1225                 1230             


Thr Pro  Glu Leu Ala Pro Ala  Pro Met Gln Ser Ala  Ala Val Ala 
    1235                 1240                 1245             


Glu Pro  Leu Pro Ser Pro Arg  Ala Gln Pro Pro Gly  Gly Thr Pro 
    1250                 1255                 1260             


Ala Asp  Ala Gly Pro Gly Gln  Gly Ser Ser Glu Glu  Glu Pro Glu 
    1265                 1270                 1275             


Leu Val  Phe Ala Val Asn Leu  Pro Pro Ala Gln Leu  Ser Ser Ser 
    1280                 1285                 1290             


Asp Glu  Glu Thr Arg Glu Glu  Leu Ala Arg Ile Gly  Leu Val Pro 
    1295                 1300                 1305             


Pro Pro  Glu Glu Phe Ala Asn  Gly Val Leu Leu Ala  Thr Pro Leu 
    1310                 1315                 1320             


Ala Gly  Pro Gly Pro Ser Pro  Thr Thr Val Pro Ser  Pro Ala Ser 
    1325                 1330                 1335             


Gly Lys  Pro Ser Ser Glu Pro  Pro Pro Ala Pro Glu  Ser Ala Ala 
    1340                 1345                 1350             


Asp Ser  Gly Val Glu Glu Ala  Asp Thr Arg Ser Ser  Ser Asp Pro 
    1355                 1360                 1365             


His Leu  Glu Thr Thr Ser Thr  Ile Ser Thr Val Ser  Ser Met Ser 
    1370                 1375                 1380             


Thr Leu  Ser Ser Glu Ser Gly  Glu Leu Thr Asp Thr  His Thr Ser 
    1385                 1390                 1395             


Phe Ala  Asp Gly His Thr Phe  Leu Leu Glu Lys Pro  Pro Val Pro 
    1400                 1405                 1410             


Pro Lys  Pro Lys Leu Lys Ser  Pro Leu Gly Lys Gly  Pro Val Thr 
    1415                 1420                 1425             


Phe Arg  Asp Pro Leu Leu Lys  Gln Ser Ser Asp Ser  Glu Leu Met 
    1430                 1435                 1440             


Ala Gln  Gln His His Ala Ala  Ser Ala Gly Leu Ala  Ser Ala Ala 
    1445                 1450                 1455             


Gly Pro  Ala Arg Pro Arg Tyr  Leu Phe Gln Arg Arg  Ser Lys Leu 
    1460                 1465                 1470             


Trp Gly  Asp Pro Val Glu Ser  Arg Gly Leu Pro Gly  Pro Glu Asp 
    1475                 1480                 1485             


Asp Lys  Pro Thr Val Ile Ser  Glu Leu Ser Ser Arg  Leu Gln Gln 
    1490                 1495                 1500             


Leu Asn  Lys Asp Thr Arg Ser  Leu Gly Glu Glu Pro  Val Gly Gly 
    1505                 1510                 1515             


Leu Gly  Ser Leu Leu Asp Pro  Ala Lys Lys Ser Pro  Ile Ala Ala 
    1520                 1525                 1530             


Ala Arg  Leu Phe Ser Ser Leu  Gly Glu Leu Ser Ser  Ile Ser Ala 
    1535                 1540                 1545             


Gln Arg  Ser Pro Gly Gly Pro  Gly Gly Gly Ala Ser  Tyr Ser Val 
    1550                 1555                 1560             


Arg Pro  Ser Gly Arg Tyr Pro  Val Ala Arg Arg Ala  Pro Ser Pro 
    1565                 1570                 1575             


Val Lys  Pro Ala Ser Leu Glu  Arg Val Glu Gly Leu  Gly Ala Gly 
    1580                 1585                 1590             


Ala Gly  Gly Ala Gly Arg Pro  Phe Gly Leu Thr Pro  Pro Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Ser Ser Leu Ser  Ile Pro His Glu Pro  Lys Glu Val 
    1610                 1615                 1620             


Arg Phe  Val Val Arg Ser Val  Ser Ala Arg Ser Arg  Ser Pro Ser 
    1625                 1630                 1635             


Pro Ser  Pro Leu Pro Ser Pro  Ala Ser Gly Pro Gly  Pro Gly Ala 
    1640                 1645                 1650             


Pro Gly  Pro Arg Arg Pro Phe  Gln Gln Lys Pro Leu  Gln Leu Trp 
    1655                 1660                 1665             


Ser Lys  Phe Asp Val Gly Asp  Trp Leu Glu Ser Ile  His Leu Gly 
    1670                 1675                 1680             


Glu His  Arg Asp Arg Phe Glu  Asp His Glu Ile Glu  Gly Ala His 
    1685                 1690                 1695             


Leu Pro  Ala Leu Thr Lys Asp  Asp Phe Val Glu Leu  Gly Val Thr 
    1700                 1705                 1710             


Arg Val  Gly His Arg Met Asn  Ile Glu Arg Ala Leu  Arg Gln Leu 
    1715                 1720                 1725             


Asp Gly  Ser 
    1730     


<210> 233
<211> 3685
<212> PRT
<213> Homo sapiens

<400> 233
Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Lys Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210> 234
<211> 2156
<212> PRT
<213> Homo sapiens

<400> 234
Met Ser Asp Thr Pro Ser Thr Gly Phe Ser Ile Ile His Pro Thr Ser 
1               5                   10                  15      


Ser Glu Gly Gln Val Pro Pro Pro Arg His Leu Ser Leu Thr His Pro 
            20                  25                  30          


Val Val Ala Lys Arg Ile Ser Phe Tyr Lys Ser Gly Asp Pro Gln Phe 
        35                  40                  45              


Gly Gly Val Arg Val Val Val Asn Pro Arg Ser Phe Lys Ser Phe Asp 
    50                  55                  60                  


Ala Leu Leu Asp Asn Leu Ser Arg Lys Val Pro Leu Pro Phe Gly Val 
65                  70                  75                  80  


Arg Asn Ile Ser Thr Pro Arg Gly Arg His Ser Ile Thr Arg Leu Glu 
                85                  90                  95      


Glu Leu Glu Asp Gly Glu Ser Tyr Leu Cys Ser His Gly Arg Lys Val 
            100                 105                 110         


Gln Pro Val Asp Leu Asp Lys Ala Arg Arg Arg Pro Arg Pro Trp Leu 
        115                 120                 125             


Ser Ser Arg Ala Ile Ser Ala His Ser Pro Pro His Pro Val Ala Val 
    130                 135                 140                 


Ala Ala Pro Gly Met Pro Arg Pro Pro Arg Ser Leu Val Val Phe Arg 
145                 150                 155                 160 


Asn Gly Asp Pro Lys Thr Arg Arg Ala Val Leu Leu Ser Arg Arg Val 
                165                 170                 175     


Thr Gln Ser Phe Glu Ala Phe Leu Gln His Leu Thr Glu Val Met Gln 
            180                 185                 190         


Arg Pro Val Val Lys Leu Tyr Ala Thr Asp Gly Arg Arg Val Pro Ser 
        195                 200                 205             


Leu Gln Ala Val Ile Leu Ser Ser Gly Ala Val Val Ala Ala Gly Arg 
    210                 215                 220                 


Glu Pro Phe Lys Pro Gly Asn Tyr Asp Ile Gln Lys Tyr Leu Leu Pro 
225                 230                 235                 240 


Ala Arg Leu Pro Gly Ile Ser Gln Arg Val Tyr Pro Lys Gly Asn Ala 
                245                 250                 255     


Lys Ser Glu Ser Arg Lys Ile Ser Thr His Met Ser Ser Ser Ser Arg 
            260                 265                 270         


Ser Gln Ile Tyr Ser Val Ser Ser Glu Lys Thr His Asn Asn Asp Cys 
        275                 280                 285             


Tyr Leu Asp Tyr Ser Phe Val Pro Glu Lys Tyr Leu Ala Leu Glu Lys 
    290                 295                 300                 


Asn Asp Ser Gln Asn Leu Pro Ile Tyr Pro Ser Glu Asp Asp Ile Glu 
305                 310                 315                 320 


Lys Ser Ile Ile Phe Asn Gln Asp Gly Thr Met Thr Val Glu Met Lys 
                325                 330                 335     


Val Arg Phe Arg Ile Lys Glu Glu Glu Thr Ile Lys Trp Thr Thr Thr 
            340                 345                 350         


Val Ser Lys Thr Gly Pro Ser Asn Asn Asp Glu Lys Ser Glu Met Ser 
        355                 360                 365             


Phe Pro Gly Arg Thr Glu Ser Arg Ser Ser Gly Leu Lys Leu Ala Ala 
    370                 375                 380                 


Cys Ser Phe Ser Ala Asp Val Ser Pro Met Glu Arg Ser Ser Asn Gln 
385                 390                 395                 400 


Glu Gly Ser Leu Ala Glu Glu Ile Asn Ile Gln Met Thr Asp Gln Val 
                405                 410                 415     


Ala Glu Thr Cys Ser Ser Ala Ser Trp Glu Asn Ala Thr Val Asp Thr 
            420                 425                 430         


Asp Ile Ile Gln Gly Thr Gln Asp Gln Ala Lys His Arg Phe Tyr Arg 
        435                 440                 445             


Pro Pro Thr Pro Gly Leu Arg Arg Val Arg Gln Lys Lys Ser Val Ile 
    450                 455                 460                 


Gly Ser Val Thr Leu Val Ser Glu Thr Glu Val Gln Glu Lys Met Ile 
465                 470                 475                 480 


Gly Gln Phe Ser Tyr Ser Glu Glu Arg Glu Ser Gly Glu Asn Lys Ser 
                485                 490                 495     


Glu Tyr His Met Phe Thr His Ser Cys Ser Lys Met Ser Ser Val Ser 
            500                 505                 510         


Asn Lys Pro Val Leu Val Gln Ile Asn Asn Asn Asp Gln Met Glu Glu 
        515                 520                 525             


Ser Ser Leu Glu Arg Lys Lys Glu Asn Ser Leu Leu Lys Ser Ser Ala 
    530                 535                 540                 


Ile Ser Ala Gly Val Ile Glu Ile Thr Ser Gln Lys Met Leu Glu Met 
545                 550                 555                 560 


Ser His Asn Asn Gly Leu Pro Ser Thr Ile Ser Asn Asn Ser Ile Val 
                565                 570                 575     


Glu Glu Asp Val Val Asp Cys Val Val Leu Asp Asn Lys Thr Gly Ile 
            580                 585                 590         


Lys Asn Phe Lys Thr Tyr Gly Asn Thr Asn Asp Arg Phe Ser Pro Ile 
        595                 600                 605             


Ser Ala Asp Ala Thr His Phe Ser Ser Asn Asn Ser Gly Thr Asp Lys 
    610                 615                 620                 


Asn Ile Ser Glu Ala Pro Ala Ser Glu Ala Ser Ser Thr Val Thr Ala 
625                 630                 635                 640 


Arg Ile Asp Arg Leu Ile Asn Glu Phe Ala Gln Cys Gly Leu Thr Lys 
                645                 650                 655     


Leu Pro Lys Asn Glu Lys Lys Ile Leu Ser Ser Val Ala Ser Lys Lys 
            660                 665                 670         


Lys Lys Lys Ser Arg Gln Gln Ala Ile Asn Ser Arg Tyr Gln Asp Gly 
        675                 680                 685             


Gln Leu Ala Thr Lys Gly Ile Leu Asn Lys Asn Glu Arg Ile Asn Thr 
    690                 695                 700                 


Lys Gly Arg Ile Thr Lys Glu Met Ile Val Gln Asp Ser Asp Ser Pro 
705                 710                 715                 720 


Leu Lys Gly Gly Ile Leu Cys Glu Glu Asp Leu Gln Lys Ser Asp Thr 
                725                 730                 735     


Val Ile Glu Ser Asn Thr Phe Cys Ser Lys Ser Asn Leu Asn Ser Thr 
            740                 745                 750         


Ile Ser Lys Asn Phe His Arg Asn Lys Leu Asn Thr Thr Gln Asn Ser 
        755                 760                 765             


Lys Val Gln Gly Leu Leu Thr Lys Arg Lys Ser Arg Ser Leu Asn Lys 
    770                 775                 780                 


Ile Ser Leu Gly Ala Pro Lys Lys Arg Glu Ile Gly Gln Arg Asp Lys 
785                 790                 795                 800 


Val Phe Pro His Asn Glu Ser Lys Tyr Cys Lys Ser Thr Phe Glu Asn 
                805                 810                 815     


Lys Ser Leu Phe His Val Phe Asn Ile Leu Glu Gln Lys Pro Lys Asp 
            820                 825                 830         


Phe Tyr Ala Pro Gln Ser Gln Ala Glu Val Ala Ser Gly Tyr Leu Arg 
        835                 840                 845             


Gly Met Ala Lys Lys Ser Leu Val Ser Lys Val Thr Asp Ser His Ile 
    850                 855                 860                 


Thr Leu Lys Ser Gln Lys Lys Arg Lys Gly Asp Lys Val Lys Ala Ser 
865                 870                 875                 880 


Ala Ile Leu Ser Lys Gln His Ala Thr Thr Arg Ala Asn Ser Leu Ala 
                885                 890                 895     


Ser Leu Lys Lys Pro Asp Phe Pro Glu Ala Ile Ala His His Ser Ile 
            900                 905                 910         


Gln Asn Tyr Ile Gln Ser Trp Leu Gln Asn Ile Asn Pro Tyr Pro Thr 
        915                 920                 925             


Leu Lys Pro Ile Lys Ser Ala Pro Val Cys Arg Asn Glu Thr Ser Val 
    930                 935                 940                 


Val Asn Cys Ser Asn Asn Ser Phe Ser Gly Asn Asp Pro His Thr Asn 
945                 950                 955                 960 


Ser Gly Lys Ile Ser Asn Phe Val Met Glu Ser Asn Lys His Ile Thr 
                965                 970                 975     


Lys Ile Ala Gly Leu Thr Gly Asp Asn Leu Cys Lys Glu Gly Asp Lys 
            980                 985                 990         


Ser Phe Ile Ala Asn Asp Thr Gly  Glu Glu Asp Leu His  Glu Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Leu Asn Asp Ala  Tyr Leu Val Pro Leu  His Glu His 
    1010                 1015                 1020             


Cys Thr  Leu Ser Gln Ser Ala  Ile Asn Asp His Asn  Thr Lys Ser 
    1025                 1030                 1035             


His Ile  Ala Ala Glu Lys Ser  Gly Pro Glu Lys Lys  Leu Val Tyr 
    1040                 1045                 1050             


Gln Glu  Ile Asn Leu Ala Arg  Lys Arg Gln Ser Val  Glu Ala Ala 
    1055                 1060                 1065             


Ile Gln  Val Asp Pro Ile Glu  Glu Glu Thr Pro Lys  Asp Leu Leu 
    1070                 1075                 1080             


Pro Val  Leu Met Leu His Gln  Leu Gln Ala Ser Val  Pro Gly Ile 
    1085                 1090                 1095             


His Lys  Thr Gln Asn Gly Val  Val Gln Met Pro Gly  Ser Leu Ala 
    1100                 1105                 1110             


Gly Val  Pro Phe His Ser Ala  Ile Cys Asn Ser Ser  Thr Asn Leu 
    1115                 1120                 1125             


Leu Leu  Ala Trp Leu Leu Val  Leu Asn Leu Lys Gly  Ser Met Asn 
    1130                 1135                 1140             


Ser Phe  Cys Gln Val Asp Ala  His Lys Ala Thr Asn  Lys Ser Ser 
    1145                 1150                 1155             


Glu Thr  Leu Ala Leu Leu Glu  Ile Leu Lys His Ile  Ala Ile Thr 
    1160                 1165                 1170             


Glu Glu  Ala Asp Asp Leu Lys  Ala Ala Val Ala Asn  Leu Val Glu 
    1175                 1180                 1185             


Ser Thr  Thr Ser His Phe Gly  Leu Ser Glu Lys Glu  Gln Asp Met 
    1190                 1195                 1200             


Val Pro  Ile Asp Leu Ser Ala  Asn Cys Ser Thr Val  Asn Ile Gln 
    1205                 1210                 1215             


Ser Val  Pro Lys Cys Ser Glu  Asn Glu Arg Thr Gln  Gly Ile Ser 
    1220                 1225                 1230             


Ser Leu  Asp Gly Gly Cys Ser  Ala Ser Glu Ala Cys  Ala Pro Glu 
    1235                 1240                 1245             


Val Cys  Val Leu Glu Val Thr  Cys Ser Pro Cys Glu  Met Cys Thr 
    1250                 1255                 1260             


Val Asn  Lys Ala Tyr Ser Pro  Lys Glu Thr Cys Asn  Pro Ser Asp 
    1265                 1270                 1275             


Thr Phe  Phe Pro Ser Asp Gly  Tyr Gly Val Asp Gln  Thr Ser Met 
    1280                 1285                 1290             


Asn Lys  Ala Cys Phe Leu Gly  Glu Val Cys Ser Leu  Thr Asp Thr 
    1295                 1300                 1305             


Val Phe  Ser Asp Lys Ala Cys  Ala Gln Lys Glu Asn  His Thr Tyr 
    1310                 1315                 1320             


Glu Gly  Ala Cys Pro Ile Asp  Glu Thr Tyr Val Pro  Val Asn Val 
    1325                 1330                 1335             


Cys Asn  Thr Ile Asp Phe Leu  Asn Ser Lys Glu Asn  Thr Tyr Thr 
    1340                 1345                 1350             


Asp Asn  Leu Asp Ser Thr Glu  Glu Leu Glu Arg Gly  Asp Asp Ile 
    1355                 1360                 1365             


Gln Lys  Asp Leu Asn Ile Leu  Thr Asp Pro Glu Tyr  Lys Asn Gly 
    1370                 1375                 1380             


Phe Asn  Thr Leu Val Ser His  Gln Asn Val Ser Asn  Leu Ser Ser 
    1385                 1390                 1395             


Cys Gly  Leu Cys Leu Ser Glu  Lys Glu Ala Glu Leu  Asp Lys Lys 
    1400                 1405                 1410             


His Ser  Ser Leu Asp Asp Phe  Glu Asn Cys Ser Leu  Arg Lys Phe 
    1415                 1420                 1425             


Gln Asp  Glu Asn Ala Tyr Thr  Ser Phe Asp Met Glu  Glu Pro Arg 
    1430                 1435                 1440             


Thr Ser  Glu Glu Pro Gly Ser  Ile Thr Asn Ser Met  Thr Ser Ser 
    1445                 1450                 1455             


Glu Arg  Asn Ile Ser Glu Leu  Glu Ser Phe Glu Glu  Leu Glu Asn 
    1460                 1465                 1470             


His Asp  Thr Asp Ile Phe Asn  Thr Val Val Asn Gly  Gly Glu Gln 
    1475                 1480                 1485             


Ala Thr  Glu Glu Leu Ile Gln  Glu Glu Val Glu Ala  Ser Lys Thr 
    1490                 1495                 1500             


Leu Glu  Leu Ile Asp Ile Ser  Ser Lys Asn Ile Met  Glu Glu Lys 
    1505                 1510                 1515             


Arg Met  Asn Gly Ile Ile Tyr  Glu Ile Ile Ser Lys  Arg Leu Ala 
    1520                 1525                 1530             


Thr Pro  Pro Ser Leu Asp Phe  Cys Tyr Asp Ser Lys  Gln Asn Ser 
    1535                 1540                 1545             


Glu Lys  Glu Thr Asn Glu Gly  Glu Thr Lys Met Val  Lys Met Met 
    1550                 1555                 1560             


Val Lys  Thr Met Glu Thr Gly  Ser Tyr Ser Glu Ser  Ser Pro Asp 
    1565                 1570                 1575             


Leu Lys  Lys Cys Ile Lys Ser  Pro Val Thr Ser Asp  Trp Ser Asp 
    1580                 1585                 1590             


Tyr Arg  Pro Asp Ser Asp Ser  Glu Gln Pro Tyr Lys  Thr Ser Ser 
    1595                 1600                 1605             


Asp Asp  Pro Asn Asp Ser Gly  Glu Leu Thr Gln Glu  Lys Glu Tyr 
    1610                 1615                 1620             


Asn Ile  Gly Phe Val Lys Arg  Ala Ile Glu Lys Leu  Tyr Gly Lys 
    1625                 1630                 1635             


Ala Asp  Ile Ile Lys Pro Ser  Phe Phe Pro Gly Ser  Thr Arg Lys 
    1640                 1645                 1650             


Ser Gln  Val Cys Pro Tyr Asn  Ser Val Glu Phe Gln  Cys Ser Arg 
    1655                 1660                 1665             


Lys Ala  Ser Leu Tyr Asp Ser  Glu Gly Gln Ser Phe  Gly Ser Ser 
    1670                 1675                 1680             


Glu Gln  Val Ser Ser Ser Ser  Ser Met Leu Gln Glu  Phe Gln Glu 
    1685                 1690                 1695             


Glu Arg  Gln Asp Lys Cys Asp  Val Ser Ala Val Arg  Asp Asn Tyr 
    1700                 1705                 1710             


Cys Arg  Gly Asp Ile Val Glu  Pro Gly Thr Lys Gln  Asn Asp Asp 
    1715                 1720                 1725             


Ser Arg  Ile Leu Thr Asp Ile  Glu Glu Gly Val Leu  Ile Asp Lys 
    1730                 1735                 1740             


Gly Lys  Trp Leu Leu Lys Glu  Asn His Leu Leu Arg  Met Ser Ser 
    1745                 1750                 1755             


Glu Asn  Pro Gly Met Cys Gly  Asn Ala Asp Thr Thr  Ser Val Asp 
    1760                 1765                 1770             


Thr Leu  Leu Asp Asn Asn Ser  Ser Glu Val Pro Tyr  Ser His Phe 
    1775                 1780                 1785             


Gly Asn  Leu Ala Pro Gly Pro  Thr Met Asp Glu Leu  Ser Ser Ser 
    1790                 1795                 1800             


Glu Leu  Glu Glu Leu Thr Gln  Pro Leu Glu Leu Lys  Cys Asn Tyr 
    1805                 1810                 1815             


Phe Asn  Met Pro His Gly Ser  Asp Ser Glu Pro Phe  His Glu Asp 
    1820                 1825                 1830             


Leu Leu  Asp Val Arg Asn Glu  Thr Cys Ala Lys Glu  Arg Ile Ala 
    1835                 1840                 1845             


Asn His  His Thr Glu Glu Lys  Gly Ser His Gln Ser  Glu Arg Val 
    1850                 1855                 1860             


Cys Thr  Ser Val Thr His Ser  Phe Ile Ser Ala Gly  Asn Lys Val 
    1865                 1870                 1875             


Tyr Pro  Val Ser Asp Asp Ala  Ile Lys Asn Gln Pro  Leu Pro Gly 
    1880                 1885                 1890             


Ser Asn  Met Ile His Gly Thr  Leu Gln Glu Ala Asp  Ser Leu Asp 
    1895                 1900                 1905             


Lys Leu  Tyr Ala Leu Cys Gly  Gln His Cys Pro Ile  Leu Thr Val 
    1910                 1915                 1920             


Ile Ile  Gln Pro Met Asn Glu  Glu Asp Arg Gly Phe  Ala Tyr Arg 
    1925                 1930                 1935             


Lys Glu  Ser Asp Ile Glu Asn  Phe Leu Gly Phe Tyr  Leu Trp Met 
    1940                 1945                 1950             


Lys Ile  His Pro Tyr Leu Leu  Gln Thr Asp Lys Asn  Val Phe Arg 
    1955                 1960                 1965             


Glu Glu  Asn Asn Lys Ala Ser  Met Arg Gln Asn Leu  Ile Asp Asn 
    1970                 1975                 1980             


Ala Ile  Gly Asp Ile Phe Asp  Gln Phe Tyr Phe Ser  Asn Thr Phe 
    1985                 1990                 1995             


Asp Leu  Met Gly Lys Arg Arg  Lys Gln Lys Arg Ile  Asn Phe Leu 
    2000                 2005                 2010             


Gly Leu  Glu Glu Glu Gly Asn  Leu Lys Lys Phe Gln  Pro Asp Leu 
    2015                 2020                 2025             


Lys Glu  Arg Phe Cys Met Asn  Phe Leu His Thr Ser  Leu Leu Val 
    2030                 2035                 2040             


Val Gly  Asn Val Asp Ser Asn  Thr Gln Asp Leu Ser  Gly Gln Thr 
    2045                 2050                 2055             


Asn Glu  Ile Phe Lys Ala Val  Asp Glu Asn Asn Asn  Leu Leu Asn 
    2060                 2065                 2070             


Asn Arg  Phe Gln Gly Ser Arg  Thr Asn Leu Asn Gln  Val Val Arg 
    2075                 2080                 2085             


Glu Asn  Ile Asn Cys His Tyr  Phe Phe Glu Met Leu  Gly Gln Ala 
    2090                 2095                 2100             


Cys Leu  Leu Asp Ile Cys Gln  Val Glu Thr Ser Leu  Asn Ile Ser 
    2105                 2110                 2115             


Asn Arg  Asn Ile Leu Glu Leu  Cys Met Phe Glu Gly  Glu Asn Leu 
    2120                 2125                 2130             


Phe Ile  Trp Glu Glu Glu Asp  Ile Leu Asn Leu Thr  Asp Leu Glu 
    2135                 2140                 2145             


Ser Ser  Arg Glu Gln Glu Asp  Leu 
    2150                 2155     


<210> 235
<211> 34350
<212> PRT
<213> Homo sapiens

<400> 235
Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val 
1               5                   10                  15      


Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe 
            20                  25                  30          


Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr 
        35                  40                  45              


Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys 
    50                  55                  60                  


Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu 
65                  70                  75                  80  


Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu 
                85                  90                  95      


Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser 
            100                 105                 110         


Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr 
        115                 120                 125             


Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile 
    130                 135                 140                 


Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val 
                165                 170                 175     


Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu 
            180                 185                 190         


Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val 
        195                 200                 205             


Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys 
    210                 215                 220                 


Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val 
225                 230                 235                 240 


Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro Pro Arg 
                245                 250                 255     


Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala 
            260                 265                 270         


Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His 
        275                 280                 285             


Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val 
    290                 295                 300                 


Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser 
305                 310                 315                 320 


Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala 
                325                 330                 335     


Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala 
            340                 345                 350         


Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr 
        355                 360                 365             


Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu 
    370                 375                 380                 


Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val 
                405                 410                 415     


Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala 
            420                 425                 430         


Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln 
        435                 440                 445             


Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln 
    450                 455                 460                 


Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val 
465                 470                 475                 480 


Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys 
                485                 490                 495     


Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln 
            500                 505                 510         


Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser 
        515                 520                 525             


Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr 
    530                 535                 540                 


Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Arg Gln Glu Thr Glu 
545                 550                 555                 560 


Ile Thr Ala Ala Ser Met Val Val Val Ala Thr Ala Lys Ser Thr Lys 
                565                 570                 575     


Leu Glu Thr Val Pro Gly Ala Gln Glu Glu Thr Thr Thr Gln Gln Asp 
            580                 585                 590         


Gln Met His Leu Ser Tyr Glu Lys Ile Met Lys Glu Thr Arg Lys Thr 
        595                 600                 605             


Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu Gln Asp 
    610                 615                 620                 


Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu Gln Val 
625                 630                 635                 640 


Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr Ala Leu 
                645                 650                 655     


Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu Thr Ile 
            660                 665                 670         


Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile Gln Val 
        675                 680                 685             


Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val Ala Thr 
    690                 695                 700                 


Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg Glu Pro 
705                 710                 715                 720 


Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu Tyr Gly 
                725                 730                 735     


Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro Gln Arg 
            740                 745                 750         


Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro Arg Val 
        755                 760                 765             


Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln Lys Gly 
    770                 775                 780                 


Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr Thr Glu 
785                 790                 795                 800 


Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro His Phe 
                805                 810                 815     


Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr Glu Ala 
            820                 825                 830         


Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu Ser Ala 
        835                 840                 845             


Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro Thr Val 
    850                 855                 860                 


Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu Pro Gln 
865                 870                 875                 880 


Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala Gly Val 
                885                 890                 895     


Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr Val Arg 
            900                 905                 910         


Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val Thr Glu 
        915                 920                 925             


Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro Pro Thr 
    930                 935                 940                 


Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu Ser Val 
945                 950                 955                 960 


Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val Thr Trp 
                965                 970                 975     


Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln Ile Thr 
            980                 985                 990         


Phe Gln Ser Gly Ile Ala Arg Leu  Met Ile Arg Glu Ala  Phe Ala Glu 
        995                 1000                 1005             


Asp Ser  Gly Arg Phe Thr Cys  Ser Ala Val Asn Glu  Ala Gly Thr 
    1010                 1015                 1020             


Val Ser  Thr Ser Cys Tyr Leu  Ala Val Gln Val Ser  Glu Glu Phe 
    1025                 1030                 1035             


Glu Lys  Glu Thr Thr Ala Val  Thr Glu Lys Phe Thr  Thr Glu Glu 
    1040                 1045                 1050             


Lys Arg  Phe Val Glu Ser Arg  Asp Val Val Met Thr  Asp Thr Ser 
    1055                 1060                 1065             


Leu Thr  Glu Glu Gln Ala Gly  Pro Gly Glu Pro Ala  Ala Pro Tyr 
    1070                 1075                 1080             


Phe Ile  Thr Lys Pro Val Val  Gln Lys Leu Val Glu  Gly Gly Ser 
    1085                 1090                 1095             


Val Val  Phe Gly Cys Gln Val  Gly Gly Asn Pro Lys  Pro His Val 
    1100                 1105                 1110             


Tyr Trp  Lys Lys Ser Gly Val  Pro Leu Thr Thr Gly  Tyr Arg Tyr 
    1115                 1120                 1125             


Lys Val  Ser Tyr Asn Lys Gln  Thr Gly Glu Cys Lys  Leu Val Ile 
    1130                 1135                 1140             


Ser Met  Thr Phe Ala Asp Asp  Ala Gly Glu Tyr Thr  Ile Val Val 
    1145                 1150                 1155             


Arg Asn  Lys His Gly Glu Thr  Ser Ala Ser Ala Ser  Leu Leu Glu 
    1160                 1165                 1170             


Glu Ala  Asp Tyr Glu Leu Leu  Met Lys Ser Gln Gln  Glu Met Leu 
    1175                 1180                 1185             


Tyr Gln  Thr Gln Val Thr Ala  Phe Val Gln Glu Pro  Lys Val Gly 
    1190                 1195                 1200             


Glu Thr  Ala Pro Gly Phe Val  Tyr Ser Glu Tyr Glu  Lys Glu Tyr 
    1205                 1210                 1215             


Glu Lys  Glu Gln Ala Leu Ile  Arg Lys Lys Met Ala  Lys Asp Thr 
    1220                 1225                 1230             


Val Val  Val Arg Thr Tyr Val  Glu Asp Gln Glu Phe  His Ile Ser 
    1235                 1240                 1245             


Ser Phe  Glu Glu Arg Leu Ile  Lys Glu Ile Glu Tyr  Arg Ile Ile 
    1250                 1255                 1260             


Lys Thr  Thr Leu Glu Glu Leu  Leu Glu Glu Asp Gly  Glu Glu Lys 
    1265                 1270                 1275             


Met Ala  Val Asp Ile Ser Glu  Ser Glu Ala Val Glu  Ser Gly Phe 
    1280                 1285                 1290             


Asp Ser  Arg Ile Lys Asn Tyr  Arg Ile Leu Glu Gly  Met Gly Val 
    1295                 1300                 1305             


Thr Phe  His Cys Lys Met Ser  Gly Tyr Pro Leu Pro  Lys Ile Ala 
    1310                 1315                 1320             


Trp Tyr  Lys Asp Gly Lys Arg  Ile Lys His Gly Glu  Arg Tyr Gln 
    1325                 1330                 1335             


Met Asp  Phe Leu Gln Asp Gly  Arg Ala Ser Leu Arg  Ile Pro Val 
    1340                 1345                 1350             


Val Leu  Pro Glu Asp Glu Gly  Ile Tyr Thr Ala Phe  Ala Ser Asn 
    1355                 1360                 1365             


Ile Lys  Gly Asn Ala Ile Cys  Ser Gly Lys Leu Tyr  Val Glu Pro 
    1370                 1375                 1380             


Ala Ala  Pro Leu Gly Ala Pro  Thr Tyr Ile Pro Thr  Leu Glu Pro 
    1385                 1390                 1395             


Val Ser  Arg Ile Arg Ser Leu  Ser Pro Arg Ser Val  Ser Arg Ser 
    1400                 1405                 1410             


Pro Ile  Arg Met Ser Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser 
    1415                 1420                 1425             


Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser Pro Gly  Arg Arg Leu 
    1430                 1435                 1440             


Glu Glu  Thr Asp Glu Ser Gln  Leu Glu Arg Leu Tyr  Lys Pro Val 
    1445                 1450                 1455             


Phe Val  Leu Lys Pro Val Ser  Phe Lys Cys Leu Glu  Gly Gln Thr 
    1460                 1465                 1470             


Ala Arg  Phe Asp Leu Lys Val  Val Gly Arg Pro Met  Pro Glu Thr 
    1475                 1480                 1485             


Phe Trp  Phe His Asp Gly Gln  Gln Ile Val Asn Asp  Tyr Thr His 
    1490                 1495                 1500             


Lys Val  Val Ile Lys Glu Asp  Gly Thr Gln Ser Leu  Ile Ile Val 
    1505                 1510                 1515             


Pro Ala  Thr Pro Ser Asp Ser  Gly Glu Trp Thr Val  Val Ala Gln 
    1520                 1525                 1530             


Asn Arg  Ala Gly Arg Ser Ser  Ile Ser Val Ile Leu  Thr Val Glu 
    1535                 1540                 1545             


Ala Val  Glu His Gln Val Lys  Pro Met Phe Val Glu  Lys Leu Lys 
    1550                 1555                 1560             


Asn Val  Asn Ile Lys Glu Gly  Ser Arg Leu Glu Met  Lys Val Arg 
    1565                 1570                 1575             


Ala Thr  Gly Asn Pro Asn Pro  Asp Ile Val Trp Leu  Lys Asn Ser 
    1580                 1585                 1590             


Asp Ile  Ile Val Pro His Lys  Tyr Pro Lys Ile Arg  Ile Glu Gly 
    1595                 1600                 1605             


Thr Lys  Gly Glu Ala Ala Leu  Lys Ile Asp Ser Thr  Val Ser Gln 
    1610                 1615                 1620             


Asp Ser  Ala Trp Tyr Thr Ala  Thr Ala Ile Asn Lys  Ala Gly Arg 
    1625                 1630                 1635             


Asp Thr  Thr Arg Cys Lys Val  Asn Val Glu Val Glu  Phe Ala Glu 
    1640                 1645                 1650             


Pro Glu  Pro Glu Arg Lys Leu  Ile Ile Pro Arg Gly  Thr Tyr Arg 
    1655                 1660                 1665             


Ala Lys  Glu Ile Ala Ala Pro  Glu Leu Glu Pro Leu  His Leu Arg 
    1670                 1675                 1680             


Tyr Gly  Gln Glu Gln Trp Glu  Glu Gly Asp Leu Tyr  Asp Lys Glu 
    1685                 1690                 1695             


Lys Gln  Gln Lys Pro Phe Phe  Lys Lys Lys Leu Thr  Ser Leu Arg 
    1700                 1705                 1710             


Leu Lys  Arg Phe Gly Pro Ala  His Phe Glu Cys Arg  Leu Thr Pro 
    1715                 1720                 1725             


Ile Gly  Asp Pro Thr Met Val  Val Glu Trp Leu His  Asp Gly Lys 
    1730                 1735                 1740             


Pro Leu  Glu Ala Ala Asn Arg  Leu Arg Met Ile Asn  Glu Phe Gly 
    1745                 1750                 1755             


Tyr Cys  Ser Leu Asp Tyr Gly  Val Ala Tyr Ser Arg  Asp Ser Gly 
    1760                 1765                 1770             


Ile Ile  Thr Cys Arg Ala Thr  Asn Lys Tyr Gly Thr  Asp His Thr 
    1775                 1780                 1785             


Ser Ala  Thr Leu Ile Val Lys  Asp Glu Lys Ser Leu  Val Glu Glu 
    1790                 1795                 1800             


Ser Gln  Leu Pro Glu Gly Arg  Lys Gly Leu Gln Arg  Ile Glu Glu 
    1805                 1810                 1815             


Leu Glu  Arg Met Ala His Glu  Gly Ala Leu Thr Gly  Val Thr Thr 
    1820                 1825                 1830             


Asp Gln  Lys Glu Lys Gln Lys  Pro Asp Ile Val Leu  Tyr Pro Glu 
    1835                 1840                 1845             


Pro Val  Arg Val Leu Glu Gly  Glu Thr Ala Arg Phe  Arg Cys Arg 
    1850                 1855                 1860             


Val Thr  Gly Tyr Pro Gln Pro  Lys Val Asn Trp Tyr  Leu Asn Gly 
    1865                 1870                 1875             


Gln Leu  Ile Arg Lys Ser Lys  Arg Phe Arg Val Arg  Tyr Asp Gly 
    1880                 1885                 1890             


Ile His  Tyr Leu Asp Ile Val  Asp Cys Lys Ser Tyr  Asp Thr Gly 
    1895                 1900                 1905             


Glu Val  Lys Val Thr Ala Glu  Asn Pro Glu Gly Val  Ile Glu His 
    1910                 1915                 1920             


Lys Val  Lys Leu Glu Ile Gln  Gln Arg Glu Asp Phe  Arg Ser Val 
    1925                 1930                 1935             


Leu Arg  Arg Ala Pro Glu Pro  Arg Pro Glu Phe His  Val His Glu 
    1940                 1945                 1950             


Pro Gly  Lys Leu Gln Phe Glu  Val Gln Lys Val Asp  Arg Pro Val 
    1955                 1960                 1965             


Asp Thr  Thr Glu Thr Lys Glu  Val Val Lys Leu Lys  Arg Ala Glu 
    1970                 1975                 1980             


Arg Ile  Thr His Glu Lys Val  Pro Glu Glu Ser Glu  Glu Leu Arg 
    1985                 1990                 1995             


Ser Lys  Phe Lys Arg Arg Thr  Glu Glu Gly Tyr Tyr  Glu Ala Ile 
    2000                 2005                 2010             


Thr Ala  Val Glu Leu Lys Ser  Arg Lys Lys Asp Glu  Ser Tyr Glu 
    2015                 2020                 2025             


Glu Leu  Leu Arg Lys Thr Lys  Asp Glu Leu Leu His  Trp Thr Lys 
    2030                 2035                 2040             


Glu Leu  Thr Glu Glu Glu Lys  Lys Ala Leu Ala Glu  Glu Gly Lys 
    2045                 2050                 2055             


Ile Thr  Ile Pro Thr Phe Lys  Pro Asp Lys Ile Glu  Leu Ser Pro 
    2060                 2065                 2070             


Ser Met  Glu Ala Pro Lys Ile  Phe Glu Arg Ile Gln  Ser Gln Thr 
    2075                 2080                 2085             


Val Gly  Gln Gly Ser Asp Ala  His Phe Arg Val Arg  Val Val Gly 
    2090                 2095                 2100             


Lys Pro  Asp Pro Glu Cys Glu  Trp Tyr Lys Asn Gly  Val Lys Ile 
    2105                 2110                 2115             


Glu Arg  Ser Asp Arg Ile Tyr  Trp Tyr Trp Pro Glu  Asp Asn Val 
    2120                 2125                 2130             


Cys Glu  Leu Val Ile Arg Asp  Val Thr Ala Glu Asp  Ser Ala Ser 
    2135                 2140                 2145             


Ile Met  Val Lys Ala Ile Asn  Ile Ala Gly Glu Thr  Ser Ser His 
    2150                 2155                 2160             


Ala Phe  Leu Leu Val Gln Ala  Lys Gln Leu Ile Thr  Phe Thr Gln 
    2165                 2170                 2175             


Glu Leu  Gln Asp Val Val Ala  Lys Glu Lys Asp Thr  Met Ala Thr 
    2180                 2185                 2190             


Phe Glu  Cys Glu Thr Ser Glu  Pro Phe Val Lys Val  Lys Trp Tyr 
    2195                 2200                 2205             


Lys Asp  Gly Met Glu Val His  Glu Gly Asp Lys Tyr  Arg Met His 
    2210                 2215                 2220             


Ser Asp  Arg Lys Val His Phe  Leu Ser Ile Leu Thr  Ile Asp Thr 
    2225                 2230                 2235             


Ser Asp  Ala Glu Asp Tyr Ser  Cys Val Leu Val Glu  Asp Glu Asn 
    2240                 2245                 2250             


Val Lys  Thr Thr Ala Lys Leu  Ile Val Glu Gly Ala  Val Val Glu 
    2255                 2260                 2265             


Phe Val  Lys Glu Leu Gln Asp  Ile Glu Val Pro Glu  Ser Tyr Ser 
    2270                 2275                 2280             


Gly Glu  Leu Glu Cys Ile Val  Ser Pro Glu Asn Ile  Glu Gly Lys 
    2285                 2290                 2295             


Trp Tyr  His Asn Asp Val Glu  Leu Lys Ser Asn Gly  Lys Tyr Thr 
    2300                 2305                 2310             


Ile Thr  Ser Arg Arg Gly Arg  Gln Asn Leu Thr Val  Lys Asp Val 
    2315                 2320                 2325             


Thr Lys  Glu Asp Gln Gly Glu  Tyr Ser Phe Val Ile  Asp Gly Lys 
    2330                 2335                 2340             


Lys Thr  Thr Cys Lys Leu Lys  Met Lys Pro Arg Pro  Ile Ala Ile 
    2345                 2350                 2355             


Leu Gln  Gly Leu Ser Asp Gln  Lys Val Cys Glu Gly  Asp Ile Val 
    2360                 2365                 2370             


Gln Leu  Glu Val Lys Val Ser  Leu Glu Ser Val Glu  Gly Val Trp 
    2375                 2380                 2385             


Met Lys  Asp Gly Gln Glu Val  Gln Pro Ser Asp Arg  Val His Ile 
    2390                 2395                 2400             


Val Ile  Asp Lys Gln Ser His  Met Leu Leu Ile Glu  Asp Met Thr 
    2405                 2410                 2415             


Lys Glu  Asp Ala Gly Asn Tyr  Ser Phe Thr Ile Pro  Ala Leu Gly 
    2420                 2425                 2430             


Leu Ser  Thr Ser Gly Arg Val  Ser Val Tyr Ser Val  Asp Val Ile 
    2435                 2440                 2445             


Thr Pro  Leu Lys Asp Val Asn  Val Ile Glu Gly Thr  Lys Ala Val 
    2450                 2455                 2460             


Leu Glu  Cys Lys Val Ser Val  Pro Asp Val Thr Ser  Val Lys Trp 
    2465                 2470                 2475             


Tyr Leu  Asn Asp Glu Gln Ile  Lys Pro Asp Asp Arg  Val Gln Ala 
    2480                 2485                 2490             


Ile Val  Lys Gly Thr Lys Gln  Arg Leu Val Ile Asn  Arg Thr His 
    2495                 2500                 2505             


Ala Ser  Asp Glu Gly Pro Tyr  Lys Leu Ile Val Gly  Arg Val Glu 
    2510                 2515                 2520             


Thr Asn  Cys Asn Leu Ser Val  Glu Lys Ile Lys Ile  Ile Arg Gly 
    2525                 2530                 2535             


Leu Arg  Asp Leu Thr Cys Thr  Glu Thr Gln Asn Val  Val Phe Glu 
    2540                 2545                 2550             


Val Glu  Leu Ser His Ser Gly  Ile Asp Val Leu Trp  Asn Phe Lys 
    2555                 2560                 2565             


Asp Lys  Glu Ile Lys Pro Ser  Ser Lys Tyr Lys Ile  Glu Ala His 
    2570                 2575                 2580             


Gly Lys  Ile Tyr Lys Leu Thr  Val Leu Asn Met Met  Lys Asp Asp 
    2585                 2590                 2595             


Glu Gly  Lys Tyr Thr Phe Tyr  Ala Gly Glu Asn Met  Thr Ser Gly 
    2600                 2605                 2610             


Lys Leu  Thr Val Ala Gly Gly  Ala Ile Ser Lys Pro  Leu Thr Asp 
    2615                 2620                 2625             


Gln Thr  Val Ala Glu Ser Gln  Glu Ala Val Phe Glu  Cys Glu Val 
    2630                 2635                 2640             


Ala Asn  Pro Asp Ser Lys Gly  Glu Trp Leu Arg Asp  Gly Lys His 
    2645                 2650                 2655             


Leu Pro  Leu Thr Asn Asn Ile  Arg Ser Glu Ser Asp  Gly His Lys 
    2660                 2665                 2670             


Arg Arg  Leu Ile Ile Ala Ala  Thr Lys Leu Asp Asp  Ile Gly Glu 
    2675                 2680                 2685             


Tyr Thr  Tyr Lys Val Ala Thr  Ser Lys Thr Ser Ala  Lys Leu Lys 
    2690                 2695                 2700             


Val Glu  Ala Val Lys Ile Lys  Lys Thr Leu Lys Asn  Leu Thr Val 
    2705                 2710                 2715             


Thr Glu  Thr Gln Asp Ala Val  Phe Thr Val Glu Leu  Thr His Pro 
    2720                 2725                 2730             


Asn Val  Lys Gly Val Gln Trp  Ile Lys Asn Gly Val  Val Leu Glu 
    2735                 2740                 2745             


Ser Asn  Glu Lys Tyr Ala Ile  Ser Val Lys Gly Thr  Ile Tyr Ser 
    2750                 2755                 2760             


Leu Arg  Ile Lys Asn Cys Ala  Ile Val Asp Glu Ser  Val Tyr Gly 
    2765                 2770                 2775             


Phe Arg  Leu Gly Arg Leu Gly  Ala Ser Ala Arg Leu  His Val Glu 
    2780                 2785                 2790             


Thr Val  Lys Ile Ile Lys Lys  Pro Lys Asp Val Thr  Ala Leu Glu 
    2795                 2800                 2805             


Asn Ala  Thr Val Ala Phe Glu  Val Ser Val Ser His  Asp Thr Val 
    2810                 2815                 2820             


Pro Val  Lys Trp Phe His Lys  Ser Val Glu Ile Lys  Pro Ser Asp 
    2825                 2830                 2835             


Lys His  Arg Leu Val Ser Glu  Arg Lys Val His Lys  Leu Met Leu 
    2840                 2845                 2850             


Gln Asn  Ile Ser Pro Ser Asp  Ala Gly Glu Tyr Thr  Ala Val Val 
    2855                 2860                 2865             


Gly Gln  Leu Glu Cys Lys Ala  Lys Leu Phe Val Glu  Thr Leu His 
    2870                 2875                 2880             


Ile Thr  Lys Thr Met Lys Asn  Ile Glu Val Pro Glu  Thr Lys Thr 
    2885                 2890                 2895             


Ala Ser  Phe Glu Cys Glu Val  Ser His Phe Asn Val  Pro Ser Met 
    2900                 2905                 2910             


Trp Leu  Lys Asn Gly Val Glu  Ile Glu Met Ser Glu  Lys Phe Lys 
    2915                 2920                 2925             


Ile Val  Val Gln Gly Lys Leu  His Gln Leu Ile Ile  Met Asn Thr 
    2930                 2935                 2940             


Ser Thr  Glu Asp Ser Ala Glu  Tyr Thr Phe Val Cys  Gly Asn Asp 
    2945                 2950                 2955             


Gln Val  Ser Ala Thr Leu Thr  Val Thr Pro Ile Met  Ile Thr Ser 
    2960                 2965                 2970             


Met Leu  Lys Asp Ile Asn Ala  Glu Glu Lys Asp Thr  Ile Thr Phe 
    2975                 2980                 2985             


Glu Val  Thr Val Asn Tyr Glu  Gly Ile Ser Tyr Lys  Trp Leu Lys 
    2990                 2995                 3000             


Asn Gly  Val Glu Ile Lys Ser  Thr Asp Lys Cys Gln  Met Arg Thr 
    3005                 3010                 3015             


Lys Lys  Leu Thr His Ser Leu  Asn Ile Arg Asn Val  His Phe Gly 
    3020                 3025                 3030             


Asp Ala  Ala Asp Tyr Thr Phe  Val Ala Gly Lys Ala  Thr Ser Thr 
    3035                 3040                 3045             


Ala Thr  Leu Tyr Val Glu Ala  Arg His Ile Glu Phe  Arg Lys His 
    3050                 3055                 3060             


Ile Lys  Asp Ile Lys Val Leu  Glu Lys Lys Arg Ala  Met Phe Glu 
    3065                 3070                 3075             


Cys Glu  Val Ser Glu Pro Asp  Ile Thr Val Gln Trp  Met Lys Asp 
    3080                 3085                 3090             


Asp Gln  Glu Leu Gln Ile Thr  Asp Arg Ile Lys Ile  Gln Lys Glu 
    3095                 3100                 3105             


Lys Tyr  Val His Arg Leu Leu  Ile Pro Ser Thr Arg  Met Ser Asp 
    3110                 3115                 3120             


Ala Gly  Lys Tyr Thr Val Val  Ala Gly Gly Asn Val  Ser Thr Ala 
    3125                 3130                 3135             


Lys Leu  Phe Val Glu Gly Arg  Asp Val Arg Ile Arg  Ser Ile Lys 
    3140                 3145                 3150             


Lys Glu  Val Gln Val Ile Glu  Lys Gln Arg Ala Val  Val Glu Phe 
    3155                 3160                 3165             


Glu Val  Asn Glu Asp Asp Val  Asp Ala His Trp Tyr  Lys Asp Gly 
    3170                 3175                 3180             


Ile Glu  Ile Asn Phe Gln Val  Gln Glu Arg His Lys  Tyr Val Val 
    3185                 3190                 3195             


Glu Arg  Arg Ile His Arg Met  Phe Ile Ser Glu Thr  Arg Gln Ser 
    3200                 3205                 3210             


Asp Ala  Gly Glu Tyr Thr Phe  Val Ala Gly Arg Asn  Arg Ser Ser 
    3215                 3220                 3225             


Val Thr  Leu Tyr Val Asn Ala  Pro Glu Pro Pro Gln  Val Leu Gln 
    3230                 3235                 3240             


Glu Leu  Gln Pro Val Thr Val  Gln Ser Gly Lys Pro  Ala Arg Phe 
    3245                 3250                 3255             


Cys Ala  Val Ile Ser Gly Arg  Pro Gln Pro Lys Ile  Ser Trp Tyr 
    3260                 3265                 3270             


Lys Glu  Glu Gln Leu Leu Ser  Thr Gly Phe Lys Cys  Lys Phe Leu 
    3275                 3280                 3285             


His Asp  Gly Gln Glu Tyr Thr  Leu Leu Leu Ile Glu  Ala Phe Pro 
    3290                 3295                 3300             


Glu Asp  Ala Ala Val Tyr Thr  Cys Glu Ala Lys Asn  Asp Tyr Gly 
    3305                 3310                 3315             


Val Ala  Thr Thr Ser Ala Ser  Leu Ser Val Glu Val  Pro Glu Val 
    3320                 3325                 3330             


Val Ser  Pro Asp Gln Glu Met  Pro Val Tyr Pro Pro  Ala Ile Ile 
    3335                 3340                 3345             


Thr Pro  Leu Gln Asp Thr Val  Thr Ser Glu Gly Gln  Pro Ala Arg 
    3350                 3355                 3360             


Phe Gln  Cys Arg Val Ser Gly  Thr Asp Leu Lys Val  Ser Trp Tyr 
    3365                 3370                 3375             


Ser Lys  Asp Lys Lys Ile Lys  Pro Ser Arg Phe Phe  Arg Met Thr 
    3380                 3385                 3390             


Gln Phe  Glu Asp Thr Tyr Gln  Leu Glu Ile Ala Glu  Ala Tyr Pro 
    3395                 3400                 3405             


Glu Asp  Glu Gly Thr Tyr Thr  Phe Val Ala Ser Asn  Ala Val Gly 
    3410                 3415                 3420             


Gln Val  Ser Ser Thr Ala Asn  Leu Ser Leu Glu Ala  Pro Glu Ser 
    3425                 3430                 3435             


Ile Leu  His Glu Arg Ile Glu  Gln Glu Ile Glu Met  Glu Met Lys 
    3440                 3445                 3450             


Glu Phe  Ser Ser Ser Phe Leu  Ser Ala Glu Glu Glu  Gly Leu His 
    3455                 3460                 3465             


Ser Ala  Glu Leu Gln Leu Ser  Lys Ile Asn Glu Thr  Leu Glu Leu 
    3470                 3475                 3480             


Leu Ser  Glu Ser Pro Val Tyr  Pro Thr Lys Phe Asp  Ser Glu Lys 
    3485                 3490                 3495             


Glu Gly  Thr Gly Pro Ile Phe  Ile Lys Glu Val Ser  Asn Ala Asp 
    3500                 3505                 3510             


Ile Ser  Met Gly Asp Val Ala  Thr Leu Ser Val Thr  Val Ile Gly 
    3515                 3520                 3525             


Ile Pro  Lys Pro Lys Ile Gln  Trp Phe Phe Asn Gly  Val Leu Leu 
    3530                 3535                 3540             


Thr Pro  Ser Ala Asp Tyr Lys  Phe Val Phe Asp Gly  Asp Asp His 
    3545                 3550                 3555             


Ser Leu  Ile Ile Leu Phe Thr  Lys Leu Glu Asp Glu  Gly Glu Tyr 
    3560                 3565                 3570             


Thr Cys  Met Ala Ser Asn Asp  Tyr Gly Lys Thr Ile  Cys Ser Ala 
    3575                 3580                 3585             


Tyr Leu  Lys Ile Asn Ser Lys  Gly Glu Gly His Lys  Asp Thr Glu 
    3590                 3595                 3600             


Thr Glu  Ser Ala Val Ala Lys  Ser Leu Glu Lys Leu  Gly Gly Pro 
    3605                 3610                 3615             


Cys Pro  Pro His Phe Leu Lys  Glu Leu Lys Pro Ile  Arg Cys Ala 
    3620                 3625                 3630             


Gln Gly  Leu Pro Ala Ile Phe  Glu Tyr Thr Val Val  Gly Glu Pro 
    3635                 3640                 3645             


Ala Pro  Thr Val Thr Trp Phe  Lys Glu Asn Lys Gln  Leu Cys Thr 
    3650                 3655                 3660             


Ser Val  Tyr Tyr Thr Ile Ile  His Asn Pro Asn Gly  Ser Gly Thr 
    3665                 3670                 3675             


Phe Ile  Val Asn Asp Pro Gln  Arg Glu Asp Ser Gly  Leu Tyr Ile 
    3680                 3685                 3690             


Cys Lys  Ala Glu Asn Met Leu  Gly Glu Ser Thr Cys  Ala Ala Glu 
    3695                 3700                 3705             


Leu Leu  Val Leu Leu Glu Asp  Thr Asp Met Thr Asp  Thr Pro Cys 
    3710                 3715                 3720             


Lys Ala  Lys Ser Thr Pro Glu  Ala Pro Glu Asp Phe  Pro Gln Thr 
    3725                 3730                 3735             


Pro Leu  Lys Gly Pro Ala Val  Glu Ala Leu Asp Ser  Glu Gln Glu 
    3740                 3745                 3750             


Ile Ala  Thr Phe Val Lys Asp  Thr Ile Leu Lys Ala  Ala Leu Ile 
    3755                 3760                 3765             


Thr Glu  Glu Asn Gln Gln Leu  Ser Tyr Glu His Ile  Ala Lys Ala 
    3770                 3775                 3780             


Asn Glu  Leu Ser Ser Gln Leu  Pro Leu Gly Ala Gln  Glu Leu Gln 
    3785                 3790                 3795             


Ser Ile  Leu Glu Gln Asp Lys  Leu Thr Pro Glu Ser  Thr Arg Glu 
    3800                 3805                 3810             


Phe Leu  Cys Ile Asn Gly Ser  Ile His Phe Gln Pro  Leu Lys Glu 
    3815                 3820                 3825             


Pro Ser  Pro Asn Leu Gln Leu  Gln Ile Val Gln Ser  Gln Lys Thr 
    3830                 3835                 3840             


Phe Ser  Lys Glu Gly Ile Leu  Met Pro Glu Glu Pro  Glu Thr Gln 
    3845                 3850                 3855             


Ala Val  Leu Ser Asp Thr Glu  Lys Ile Phe Pro Ser  Ala Met Ser 
    3860                 3865                 3870             


Ile Glu  Gln Ile Asn Ser Leu  Thr Val Glu Pro Leu  Lys Thr Leu 
    3875                 3880                 3885             


Leu Ala  Glu Pro Glu Gly Asn  Tyr Pro Gln Ser Ser  Ile Glu Pro 
    3890                 3895                 3900             


Pro Met  His Ser Tyr Leu Thr  Ser Val Ala Glu Glu  Val Leu Ser 
    3905                 3910                 3915             


Pro Lys  Glu Lys Thr Val Ser  Asp Thr Asn Arg Glu  Gln Arg Val 
    3920                 3925                 3930             


Thr Leu  Gln Lys Gln Glu Ala  Gln Ser Ala Leu Ile  Leu Ser Gln 
    3935                 3940                 3945             


Ser Leu  Ala Glu Gly His Val  Glu Ser Leu Gln Ser  Pro Asp Val 
    3950                 3955                 3960             


Met Ile  Ser Gln Val Asn Tyr  Glu Pro Leu Val Pro  Ser Glu His 
    3965                 3970                 3975             


Ser Cys  Thr Glu Gly Gly Lys  Ile Leu Ile Glu Ser  Ala Asn Pro 
    3980                 3985                 3990             


Leu Glu  Asn Ala Gly Gln Asp  Ser Ala Val Arg Ile  Glu Glu Gly 
    3995                 4000                 4005             


Lys Ser  Leu Arg Phe Pro Leu  Ala Leu Glu Glu Lys  Gln Val Leu 
    4010                 4015                 4020             


Leu Lys  Glu Glu His Ser Asp  Asn Val Val Met Pro  Pro Asp Gln 
    4025                 4030                 4035             


Ile Ile  Glu Ser Lys Arg Glu  Pro Val Ala Ile Lys  Lys Val Gln 
    4040                 4045                 4050             


Glu Val  Gln Gly Arg Asp Leu  Leu Ser Lys Glu Ser  Leu Leu Ser 
    4055                 4060                 4065             


Gly Ile  Pro Glu Glu Gln Arg  Leu Asn Leu Lys Ile  Gln Ile Cys 
    4070                 4075                 4080             


Arg Ala  Leu Gln Ala Ala Val  Ala Ser Glu Gln Pro  Gly Leu Phe 
    4085                 4090                 4095             


Ser Glu  Trp Leu Arg Asn Ile  Glu Lys Val Glu Val  Glu Ala Val 
    4100                 4105                 4110             


Asn Ile  Thr Gln Glu Pro Arg  His Ile Met Cys Met  Tyr Leu Val 
    4115                 4120                 4125             


Thr Ser  Ala Lys Ser Val Thr  Glu Glu Val Thr Ile  Ile Ile Glu 
    4130                 4135                 4140             


Asp Val  Asp Pro Gln Met Ala  Asn Leu Lys Met Glu  Leu Arg Asp 
    4145                 4150                 4155             


Ala Leu  Cys Ala Ile Ile Tyr  Glu Glu Ile Asp Ile  Leu Thr Ala 
    4160                 4165                 4170             


Glu Gly  Pro Arg Ile Gln Gln  Gly Ala Lys Thr Ser  Leu Gln Glu 
    4175                 4180                 4185             


Glu Met  Asp Ser Phe Ser Gly  Ser Gln Lys Val Glu  Pro Ile Thr 
    4190                 4195                 4200             


Glu Pro  Glu Val Glu Ser Lys  Tyr Leu Ile Ser Thr  Glu Glu Val 
    4205                 4210                 4215             


Ser Tyr  Phe Asn Val Gln Ser  Arg Val Lys Tyr Leu  Asp Ala Thr 
    4220                 4225                 4230             


Pro Val  Thr Lys Gly Val Ala  Ser Ala Val Val Ser  Asp Glu Lys 
    4235                 4240                 4245             


Gln Asp  Glu Ser Leu Lys Pro  Ser Glu Glu Lys Glu  Glu Ser Ser 
    4250                 4255                 4260             


Ser Glu  Ser Gly Thr Glu Glu  Val Ala Thr Val Lys  Ile Gln Glu 
    4265                 4270                 4275             


Ala Glu  Gly Gly Leu Ile Lys  Glu Asp Gly Pro Met  Ile His Thr 
    4280                 4285                 4290             


Pro Leu  Val Asp Thr Val Ser  Glu Glu Gly Asp Ile  Val His Leu 
    4295                 4300                 4305             


Thr Thr  Ser Ile Thr Asn Ala  Lys Glu Val Asn Trp  Tyr Phe Glu 
    4310                 4315                 4320             


Asn Lys  Leu Val Pro Ser Asp  Glu Lys Phe Lys Cys  Leu Gln Asp 
    4325                 4330                 4335             


Gln Asn  Thr Tyr Thr Leu Val  Ile Asp Lys Val Asn  Thr Glu Asp 
    4340                 4345                 4350             


His Gln  Gly Glu Tyr Val Cys  Glu Ala Leu Asn Asp  Ser Gly Lys 
    4355                 4360                 4365             


Thr Ala  Thr Ser Ala Lys Leu  Thr Val Val Lys Arg  Ala Ala Pro 
    4370                 4375                 4380             


Val Ile  Lys Arg Lys Ile Glu  Pro Leu Glu Val Ala  Leu Gly His 
    4385                 4390                 4395             


Leu Ala  Lys Phe Thr Cys Glu  Ile Gln Ser Ala Pro  Asn Val Arg 
    4400                 4405                 4410             


Phe Gln  Trp Phe Lys Ala Gly  Arg Glu Ile Tyr Glu  Ser Asp Lys 
    4415                 4420                 4425             


Cys Ser  Ile Arg Ser Ser Lys  Tyr Ile Ser Ser Leu  Glu Ile Leu 
    4430                 4435                 4440             


Arg Thr  Gln Val Val Asp Cys  Gly Glu Tyr Thr Cys  Lys Ala Ser 
    4445                 4450                 4455             


Asn Glu  Tyr Gly Ser Val Ser  Cys Thr Ala Thr Leu  Thr Val Thr 
    4460                 4465                 4470             


Glu Ala  Tyr Pro Pro Thr Phe  Leu Ser Arg Pro Lys  Ser Leu Thr 
    4475                 4480                 4485             


Thr Phe  Val Gly Lys Ala Ala  Lys Phe Ile Cys Thr  Val Thr Gly 
    4490                 4495                 4500             


Thr Pro  Val Ile Glu Thr Ile  Trp Gln Lys Asp Gly  Ala Ala Leu 
    4505                 4510                 4515             


Ser Pro  Ser Pro Asn Trp Arg  Ile Ser Asp Ala Glu  Asn Lys His 
    4520                 4525                 4530             


Ile Leu  Glu Leu Ser Asn Leu  Thr Ile Gln Asp Arg  Gly Val Tyr 
    4535                 4540                 4545             


Ser Cys  Lys Ala Ser Asn Lys  Phe Gly Ala Asp Ile  Cys Gln Ala 
    4550                 4555                 4560             


Glu Leu  Ile Ile Ile Asp Lys  Pro His Phe Ile Lys  Glu Leu Glu 
    4565                 4570                 4575             


Pro Val  Gln Ser Ala Ile Asn  Lys Lys Val His Leu  Glu Cys Gln 
    4580                 4585                 4590             


Val Asp  Glu Asp Arg Lys Val  Thr Val Thr Trp Ser  Lys Asp Gly 
    4595                 4600                 4605             


Gln Lys  Leu Pro Pro Gly Lys  Asp Tyr Lys Ile Cys  Phe Glu Asp 
    4610                 4615                 4620             


Lys Ile  Ala Thr Leu Glu Ile  Pro Leu Ala Lys Leu  Lys Asp Ser 
    4625                 4630                 4635             


Gly Thr  Tyr Val Cys Thr Ala  Ser Asn Glu Ala Gly  Ser Ser Ser 
    4640                 4645                 4650             


Cys Ser  Ala Thr Val Thr Val  Arg Glu Pro Pro Ser  Phe Val Lys 
    4655                 4660                 4665             


Lys Val  Asp Pro Ser Tyr Leu  Met Leu Pro Gly Glu  Ser Ala Arg 
    4670                 4675                 4680             


Leu His  Cys Lys Leu Lys Gly  Ser Pro Val Ile Gln  Val Thr Trp 
    4685                 4690                 4695             


Phe Lys  Asn Asn Lys Glu Leu  Ser Glu Ser Asn Thr  Val Arg Met 
    4700                 4705                 4710             


Tyr Phe  Val Asn Ser Glu Ala  Ile Leu Asp Ile Thr  Asp Val Lys 
    4715                 4720                 4725             


Val Glu  Asp Ser Gly Ser Tyr  Ser Cys Glu Ala Val  Asn Asp Val 
    4730                 4735                 4740             


Gly Ser  Asp Ser Cys Ser Thr  Glu Ile Val Ile Lys  Glu Pro Pro 
    4745                 4750                 4755             


Ser Phe  Ile Lys Thr Leu Glu  Pro Ala Asp Ile Val  Arg Gly Thr 
    4760                 4765                 4770             


Asn Ala  Leu Leu Gln Cys Glu  Val Ser Gly Thr Gly  Pro Phe Glu 
    4775                 4780                 4785             


Ile Ser  Trp Phe Lys Asp Lys  Lys Gln Ile Arg Ser  Ser Lys Lys 
    4790                 4795                 4800             


Tyr Arg  Leu Phe Ser Gln Lys  Ser Leu Val Cys Leu  Glu Ile Phe 
    4805                 4810                 4815             


Ser Phe  Asn Ser Ala Asp Val  Gly Glu Tyr Glu Cys  Val Val Ala 
    4820                 4825                 4830             


Asn Glu  Val Gly Lys Cys Gly  Cys Met Ala Thr His  Leu Leu Lys 
    4835                 4840                 4845             


Glu Pro  Pro Thr Phe Val Lys  Lys Val Asp Asp Leu  Ile Ala Leu 
    4850                 4855                 4860             


Gly Gly  Gln Thr Val Thr Leu  Gln Ala Ala Val Arg  Gly Ser Glu 
    4865                 4870                 4875             


Pro Ile  Ser Val Thr Trp Met  Lys Gly Gln Glu Val  Ile Arg Glu 
    4880                 4885                 4890             


Asp Gly  Lys Ile Lys Met Ser  Phe Ser Asn Gly Val  Ala Val Leu 
    4895                 4900                 4905             


Ile Ile  Pro Asp Val Gln Ile  Ser Phe Gly Gly Lys  Tyr Thr Cys 
    4910                 4915                 4920             


Leu Ala  Glu Asn Glu Ala Gly  Ser Gln Thr Ser Val  Gly Glu Leu 
    4925                 4930                 4935             


Ile Val  Lys Glu Pro Ala Lys  Ile Ile Glu Arg Ala  Glu Leu Ile 
    4940                 4945                 4950             


Gln Val  Thr Ala Gly Asp Pro  Ala Thr Leu Glu Tyr  Thr Val Ala 
    4955                 4960                 4965             


Gly Thr  Pro Glu Leu Lys Pro  Lys Trp Tyr Lys Asp  Gly Arg Pro 
    4970                 4975                 4980             


Leu Val  Ala Ser Lys Lys Tyr  Arg Ile Ser Phe Lys  Asn Asn Val 
    4985                 4990                 4995             


Ala Gln  Leu Lys Phe Tyr Ser  Ala Glu Leu His Asp  Ser Gly Gln 
    5000                 5005                 5010             


Tyr Thr  Phe Glu Ile Ser Asn  Glu Val Gly Ser Ser  Ser Cys Glu 
    5015                 5020                 5025             


Thr Thr  Phe Thr Val Leu Asp  Arg Asp Ile Ala Pro  Phe Phe Thr 
    5030                 5035                 5040             


Lys Pro  Leu Arg Asn Val Asp  Ser Val Val Asn Gly  Thr Cys Arg 
    5045                 5050                 5055             


Leu Asp  Cys Lys Ile Ala Gly  Ser Leu Pro Met Arg  Val Ser Trp 
    5060                 5065                 5070             


Phe Lys  Asp Gly Lys Glu Ile  Ala Ala Ser Asp Arg  Tyr Arg Ile 
    5075                 5080                 5085             


Ala Phe  Val Glu Gly Thr Ala  Ser Leu Glu Ile Ile  Arg Val Asp 
    5090                 5095                 5100             


Met Asn  Asp Ala Gly Asn Phe  Thr Cys Arg Ala Thr  Asn Ser Val 
    5105                 5110                 5115             


Gly Ser  Lys Asp Ser Ser Gly  Ala Leu Ile Val Gln  Glu Pro Pro 
    5120                 5125                 5130             


Ser Phe  Val Thr Lys Pro Gly  Ser Lys Asp Val Leu  Pro Gly Ser 
    5135                 5140                 5145             


Ala Val  Cys Leu Lys Ser Thr  Phe Gln Gly Ser Thr  Pro Leu Thr 
    5150                 5155                 5160             


Ile Arg  Trp Phe Lys Gly Asn  Lys Glu Leu Val Ser  Gly Gly Ser 
    5165                 5170                 5175             


Cys Tyr  Ile Thr Lys Glu Ala  Leu Glu Ser Ser Leu  Glu Leu Tyr 
    5180                 5185                 5190             


Leu Val  Lys Thr Ser Asp Ser  Gly Thr Tyr Thr Cys  Lys Val Ser 
    5195                 5200                 5205             


Asn Val  Ala Gly Gly Val Glu  Cys Ser Ala Asn Leu  Phe Val Lys 
    5210                 5215                 5220             


Glu Pro  Ala Thr Phe Val Glu  Lys Leu Glu Pro Ser  Gln Leu Leu 
    5225                 5230                 5235             


Lys Lys  Gly Asp Ala Thr Gln  Leu Ala Cys Lys Val  Thr Gly Thr 
    5240                 5245                 5250             


Pro Pro  Ile Lys Ile Thr Trp  Phe Ala Asn Asp Arg  Glu Ile Lys 
    5255                 5260                 5265             


Glu Ser  Ser Lys His Arg Met  Ser Phe Val Glu Ser  Thr Ala Val 
    5270                 5275                 5280             


Leu Arg  Leu Thr Asp Val Gly  Ile Glu Asp Ser Gly  Glu Tyr Met 
    5285                 5290                 5295             


Cys Glu  Ala Gln Asn Glu Ala  Gly Ser Asp His Cys  Ser Ser Ile 
    5300                 5305                 5310             


Val Ile  Val Lys Glu Ser Pro  Tyr Phe Thr Lys Glu  Phe Lys Pro 
    5315                 5320                 5325             


Ile Glu  Val Leu Lys Glu Tyr  Asp Val Met Leu Leu  Ala Glu Val 
    5330                 5335                 5340             


Ala Gly  Thr Pro Pro Phe Glu  Ile Thr Trp Phe Lys  Asp Asn Thr 
    5345                 5350                 5355             


Ile Leu  Arg Ser Gly Arg Lys  Tyr Lys Thr Phe Ile  Gln Asp His 
    5360                 5365                 5370             


Leu Val  Ser Leu Gln Ile Leu  Lys Phe Val Ala Ala  Asp Ala Gly 
    5375                 5380                 5385             


Glu Tyr  Gln Cys Arg Val Thr  Asn Glu Val Gly Ser  Ser Ile Cys 
    5390                 5395                 5400             


Ser Ala  Arg Val Thr Leu Arg  Glu Pro Pro Ser Phe  Ile Lys Lys 
    5405                 5410                 5415             


Ile Glu  Ser Thr Ser Ser Leu  Arg Gly Gly Thr Ala  Ala Phe Gln 
    5420                 5425                 5430             


Ala Thr  Leu Lys Gly Ser Leu  Pro Ile Thr Val Thr  Trp Leu Lys 
    5435                 5440                 5445             


Asp Ser  Asp Glu Ile Thr Glu  Asp Asp Asn Ile Arg  Met Thr Phe 
    5450                 5455                 5460             


Glu Asn  Asn Val Ala Ser Leu  Tyr Leu Ser Gly Ile  Glu Val Lys 
    5465                 5470                 5475             


His Asp  Gly Lys Tyr Val Cys  Gln Ala Lys Asn Asp  Ala Gly Ile 
    5480                 5485                 5490             


Gln Arg  Cys Ser Ala Leu Leu  Ser Val Lys Glu Pro  Ala Thr Ile 
    5495                 5500                 5505             


Thr Glu  Glu Ala Val Ser Ile  Asp Val Thr Gln Gly  Asp Pro Ala 
    5510                 5515                 5520             


Thr Leu  Gln Val Lys Phe Ser  Gly Thr Lys Glu Ile  Thr Ala Lys 
    5525                 5530                 5535             


Trp Phe  Lys Asp Gly Gln Glu  Leu Thr Leu Gly Ser  Lys Tyr Lys 
    5540                 5545                 5550             


Ile Ser  Val Thr Asp Thr Val  Ser Ile Leu Lys Ile  Ile Ser Thr 
    5555                 5560                 5565             


Glu Lys  Lys Asp Ser Gly Glu  Tyr Thr Phe Glu Val  Gln Asn Asp 
    5570                 5575                 5580             


Val Gly  Arg Ser Ser Cys Lys  Ala Arg Ile Asn Val  Leu Asp Leu 
    5585                 5590                 5595             


Ile Ile  Pro Pro Ser Phe Thr  Lys Lys Leu Lys Lys  Met Asp Ser 
    5600                 5605                 5610             


Ile Lys  Gly Ser Phe Ile Asp  Leu Glu Cys Ile Val  Ala Gly Ser 
    5615                 5620                 5625             


His Pro  Ile Ser Ile Gln Trp  Phe Lys Asp Asp Gln  Glu Ile Ser 
    5630                 5635                 5640             


Ala Ser  Glu Lys Tyr Lys Phe  Ser Phe His Asp Asn  Thr Ala Phe 
    5645                 5650                 5655             


Leu Glu  Ile Ser Gln Leu Glu  Gly Thr Asp Ser Gly  Thr Tyr Thr 
    5660                 5665                 5670             


Cys Ser  Ala Thr Asn Lys Ala  Gly His Asn Gln Cys  Ser Gly His 
    5675                 5680                 5685             


Leu Thr  Val Lys Glu Pro Pro  Tyr Phe Val Glu Lys  Pro Gln Ser 
    5690                 5695                 5700             


Gln Asp  Val Asn Pro Asn Thr  Arg Val Gln Leu Lys  Ala Leu Val 
    5705                 5710                 5715             


Gly Gly  Thr Ala Pro Met Thr  Ile Lys Trp Phe Lys  Asp Asn Lys 
    5720                 5725                 5730             


Glu Leu  His Ser Gly Ala Ala  Arg Ser Val Trp Lys  Asp Asp Thr 
    5735                 5740                 5745             


Ser Thr  Ser Leu Glu Leu Phe  Ala Ala Lys Ala Thr  Asp Ser Gly 
    5750                 5755                 5760             


Thr Tyr  Ile Cys Gln Leu Ser  Asn Asp Val Gly Thr  Ala Thr Ser 
    5765                 5770                 5775             


Lys Ala  Thr Leu Phe Val Lys  Glu Pro Pro Gln Phe  Ile Lys Lys 
    5780                 5785                 5790             


Pro Ser  Pro Val Leu Val Leu  Arg Asn Gly Gln Ser  Thr Thr Phe 
    5795                 5800                 5805             


Glu Cys  Gln Ile Thr Gly Thr  Pro Lys Ile Arg Val  Ser Trp Tyr 
    5810                 5815                 5820             


Leu Asp  Gly Asn Glu Ile Thr  Ala Ile Gln Lys His  Gly Ile Ser 
    5825                 5830                 5835             


Phe Ile  Asp Gly Leu Ala Thr  Phe Gln Ile Ser Gly  Ala Arg Val 
    5840                 5845                 5850             


Glu Asn  Ser Gly Thr Tyr Val  Cys Glu Ala Arg Asn  Asp Ala Gly 
    5855                 5860                 5865             


Thr Ala  Ser Cys Ser Ile Glu  Leu Lys Val Lys Glu  Pro Pro Thr 
    5870                 5875                 5880             


Phe Ile  Arg Glu Leu Lys Pro  Val Glu Val Val Lys  Tyr Ser Asp 
    5885                 5890                 5895             


Val Glu  Leu Glu Cys Glu Val  Thr Gly Thr Pro Pro  Phe Glu Val 
    5900                 5905                 5910             


Thr Trp  Leu Lys Asn Asn Arg  Glu Ile Arg Ser Ser  Lys Lys Tyr 
    5915                 5920                 5925             


Thr Leu  Thr Asp Arg Val Ser  Val Phe Asn Leu His  Ile Thr Lys 
    5930                 5935                 5940             


Cys Asp  Pro Ser Asp Thr Gly  Glu Tyr Gln Cys Ile  Val Ser Asn 
    5945                 5950                 5955             


Glu Gly  Gly Ser Cys Ser Cys  Ser Thr Arg Val Ala  Leu Lys Glu 
    5960                 5965                 5970             


Pro Pro  Ser Phe Ile Lys Lys  Ile Glu Asn Thr Thr  Thr Val Leu 
    5975                 5980                 5985             


Lys Ser  Ser Ala Thr Phe Gln  Ser Thr Val Ala Gly  Ser Pro Pro 
    5990                 5995                 6000             


Ile Ser  Ile Thr Trp Leu Lys  Asp Asp Gln Ile Leu  Asp Glu Asp 
    6005                 6010                 6015             


Asp Asn  Val Tyr Ile Ser Phe  Val Asp Ser Val Ala  Thr Leu Gln 
    6020                 6025                 6030             


Ile Arg  Ser Val Asp Asn Gly  His Ser Gly Arg Tyr  Thr Cys Gln 
    6035                 6040                 6045             


Ala Lys  Asn Glu Ser Gly Val  Glu Arg Cys Tyr Ala  Phe Leu Leu 
    6050                 6055                 6060             


Val Gln  Glu Pro Ala Gln Ile  Val Glu Lys Ala Lys  Ser Val Asp 
    6065                 6070                 6075             


Val Thr  Glu Lys Asp Pro Met  Thr Leu Glu Cys Val  Val Ala Gly 
    6080                 6085                 6090             


Thr Pro  Glu Leu Lys Val Lys  Trp Leu Lys Asp Gly  Lys Gln Ile 
    6095                 6100                 6105             


Val Pro  Ser Arg Tyr Phe Ser  Met Ser Phe Glu Asn  Asn Val Ala 
    6110                 6115                 6120             


Ser Phe  Arg Ile Gln Ser Val  Met Lys Gln Asp Ser  Gly Gln Tyr 
    6125                 6130                 6135             


Thr Phe  Lys Val Glu Asn Asp  Phe Gly Ser Ser Ser  Cys Asp Ala 
    6140                 6145                 6150             


Tyr Leu  Arg Val Leu Asp Gln  Asn Ile Pro Pro Ser  Phe Thr Lys 
    6155                 6160                 6165             


Lys Leu  Thr Lys Met Asp Lys  Val Leu Gly Ser Ser  Ile His Met 
    6170                 6175                 6180             


Glu Cys  Lys Val Ser Gly Ser  Leu Pro Ile Ser Ala  Gln Trp Phe 
    6185                 6190                 6195             


Lys Asp  Gly Lys Glu Ile Ser  Thr Ser Ala Lys Tyr  Arg Leu Val 
    6200                 6205                 6210             


Cys His  Glu Arg Ser Val Ser  Leu Glu Val Asn Asn  Leu Glu Leu 
    6215                 6220                 6225             


Glu Asp  Thr Ala Asn Tyr Thr  Cys Lys Val Ser Asn  Val Ala Gly 
    6230                 6235                 6240             


Asp Asp  Ala Cys Ser Gly Ile  Leu Thr Val Lys Glu  Pro Pro Ser 
    6245                 6250                 6255             


Phe Leu  Val Lys Pro Gly Arg  Gln Gln Ala Ile Pro  Asp Ser Thr 
    6260                 6265                 6270             


Val Glu  Phe Lys Ala Ile Leu  Lys Gly Thr Pro Pro  Phe Lys Ile 
    6275                 6280                 6285             


Lys Trp  Phe Lys Asp Asp Val  Glu Leu Val Ser Gly  Pro Lys Cys 
    6290                 6295                 6300             


Phe Ile  Gly Leu Glu Gly Ser  Thr Ser Phe Leu Asn  Leu Tyr Ser 
    6305                 6310                 6315             


Val Asp  Ala Ser Lys Thr Gly  Gln Tyr Thr Cys His  Val Thr Asn 
    6320                 6325                 6330             


Asp Val  Gly Ser Asp Ser Cys  Thr Thr Met Leu Leu  Val Thr Glu 
    6335                 6340                 6345             


Pro Pro  Lys Phe Val Lys Lys  Leu Glu Ala Ser Lys  Ile Val Lys 
    6350                 6355                 6360             


Ala Gly  Asp Ser Ser Arg Leu  Glu Cys Lys Ile Ala  Gly Ser Pro 
    6365                 6370                 6375             


Glu Ile  Arg Val Val Trp Phe  Arg Asn Glu His Glu  Leu Pro Ala 
    6380                 6385                 6390             


Ser Asp  Lys Tyr Arg Met Thr  Phe Ile Asp Ser Val  Ala Val Ile 
    6395                 6400                 6405             


Gln Met  Asn Asn Leu Ser Thr  Glu Asp Ser Gly Asp  Phe Ile Cys 
    6410                 6415                 6420             


Glu Ala  Gln Asn Pro Ala Gly  Ser Thr Ser Cys Ser  Thr Lys Val 
    6425                 6430                 6435             


Ile Val  Lys Glu Pro Pro Val  Phe Ser Ser Phe Pro  Pro Ile Val 
    6440                 6445                 6450             


Glu Thr  Leu Lys Asn Ala Glu  Val Ser Leu Glu Cys  Glu Leu Ser 
    6455                 6460                 6465             


Gly Thr  Pro Pro Phe Glu Val  Val Trp Tyr Lys Asp  Lys Arg Gln 
    6470                 6475                 6480             


Leu Arg  Ser Ser Lys Lys Tyr  Lys Ile Ala Ser Lys  Asn Phe His 
    6485                 6490                 6495             


Thr Ser  Ile His Ile Leu Asn  Val Asp Thr Ser Asp  Ile Gly Glu 
    6500                 6505                 6510             


Tyr His  Cys Lys Ala Gln Asn  Glu Val Gly Ser Asp  Thr Cys Val 
    6515                 6520                 6525             


Cys Thr  Val Lys Leu Lys Glu  Pro Pro Arg Phe Val  Ser Lys Leu 
    6530                 6535                 6540             


Asn Ser  Leu Thr Val Val Ala  Gly Glu Pro Ala Glu  Leu Gln Ala 
    6545                 6550                 6555             


Ser Ile  Glu Gly Ala Gln Pro  Ile Phe Val Gln Trp  Leu Lys Glu 
    6560                 6565                 6570             


Lys Glu  Glu Val Ile Arg Glu  Ser Glu Asn Ile Arg  Ile Thr Phe 
    6575                 6580                 6585             


Val Glu  Asn Val Ala Thr Leu  Gln Phe Ala Lys Ala  Glu Pro Ala 
    6590                 6595                 6600             


Asn Ala  Gly Lys Tyr Ile Cys  Gln Ile Lys Asn Asp  Gly Gly Met 
    6605                 6610                 6615             


Arg Glu  Asn Met Ala Thr Leu  Met Val Leu Glu Pro  Ala Val Ile 
    6620                 6625                 6630             


Val Glu  Lys Ala Gly Pro Met  Thr Val Thr Val Gly  Glu Thr Cys 
    6635                 6640                 6645             


Thr Leu  Glu Cys Lys Val Ala  Gly Thr Pro Glu Leu  Ser Val Glu 
    6650                 6655                 6660             


Trp Tyr  Lys Asp Gly Lys Leu  Leu Thr Ser Ser Gln  Lys His Lys 
    6665                 6670                 6675             


Phe Ser  Phe Tyr Asn Lys Ile  Ser Ser Leu Arg Ile  Leu Ser Val 
    6680                 6685                 6690             


Glu Arg  Gln Asp Ala Gly Thr  Tyr Thr Phe Gln Val  Gln Asn Asn 
    6695                 6700                 6705             


Val Gly  Lys Ser Ser Cys Thr  Ala Val Val Asp Val  Ser Asp Arg 
    6710                 6715                 6720             


Ala Val  Pro Pro Ser Phe Thr  Arg Arg Leu Lys Asn  Thr Gly Gly 
    6725                 6730                 6735             


Val Leu  Gly Ala Ser Cys Ile  Leu Glu Cys Lys Val  Ala Gly Ser 
    6740                 6745                 6750             


Ser Pro  Ile Ser Val Ala Trp  Phe His Glu Lys Thr  Lys Ile Val 
    6755                 6760                 6765             


Ser Gly  Ala Lys Tyr Gln Thr  Thr Phe Ser Asp Asn  Val Cys Thr 
    6770                 6775                 6780             


Leu Gln  Leu Asn Ser Leu Asp  Ser Ser Asp Met Gly  Asn Tyr Thr 
    6785                 6790                 6795             


Cys Val  Ala Ala Asn Val Ala  Gly Ser Asp Glu Cys  Arg Ala Val 
    6800                 6805                 6810             


Leu Thr  Val Gln Glu Pro Pro  Ser Phe Val Lys Glu  Pro Glu Pro 
    6815                 6820                 6825             


Leu Glu  Val Leu Pro Gly Lys  Asn Val Thr Phe Thr  Ser Val Ile 
    6830                 6835                 6840             


Arg Gly  Thr Pro Pro Phe Lys  Val Asn Trp Phe Arg  Gly Ala Arg 
    6845                 6850                 6855             


Glu Leu  Val Lys Gly Asp Arg  Cys Asn Ile Tyr Phe  Glu Asp Thr 
    6860                 6865                 6870             


Val Ala  Glu Leu Glu Leu Phe  Asn Ile Asp Ile Ser  Gln Ser Gly 
    6875                 6880                 6885             


Glu Tyr  Thr Cys Val Val Ser  Asn Asn Ala Gly Gln  Ala Ser Cys 
    6890                 6895                 6900             


Thr Thr  Arg Leu Phe Val Lys  Glu Pro Ala Ala Phe  Leu Lys Arg 
    6905                 6910                 6915             


Leu Ser  Asp His Ser Val Glu  Pro Gly Lys Ser Ile  Ile Leu Glu 
    6920                 6925                 6930             


Ser Thr  Tyr Thr Gly Thr Leu  Pro Ile Ser Val Thr  Trp Lys Lys 
    6935                 6940                 6945             


Asp Gly  Phe Asn Ile Thr Thr  Ser Glu Lys Cys Asn  Ile Val Thr 
    6950                 6955                 6960             


Thr Glu  Lys Thr Cys Ile Leu  Glu Ile Leu Asn Ser  Thr Lys Arg 
    6965                 6970                 6975             


Asp Ala  Gly Gln Tyr Ser Cys  Glu Ile Glu Asn Glu  Ala Gly Arg 
    6980                 6985                 6990             


Asp Val  Cys Gly Ala Leu Val  Ser Thr Leu Glu Pro  Pro Tyr Phe 
    6995                 7000                 7005             


Val Thr  Glu Leu Glu Pro Leu  Glu Ala Ala Val Gly  Asp Ser Val 
    7010                 7015                 7020             


Ser Leu  Gln Cys Gln Val Ala  Gly Thr Pro Glu Ile  Thr Val Ser 
    7025                 7030                 7035             


Trp Tyr  Lys Gly Asp Thr Lys  Leu Arg Pro Thr Pro  Glu Tyr Arg 
    7040                 7045                 7050             


Thr Tyr  Phe Thr Asn Asn Val  Ala Thr Leu Val Phe  Asn Lys Val 
    7055                 7060                 7065             


Asn Ile  Asn Asp Ser Gly Glu  Tyr Thr Cys Lys Ala  Glu Asn Ser 
    7070                 7075                 7080             


Ile Gly  Thr Ala Ser Ser Lys  Thr Val Phe Arg Ile  Gln Glu Arg 
    7085                 7090                 7095             


Gln Leu  Pro Pro Ser Phe Ala  Arg Gln Leu Lys Asp  Ile Glu Gln 
    7100                 7105                 7110             


Thr Val  Gly Leu Pro Val Thr  Leu Thr Cys Arg Leu  Asn Gly Ser 
    7115                 7120                 7125             


Ala Pro  Ile Gln Val Cys Trp  Tyr Arg Asp Gly Val  Leu Leu Arg 
    7130                 7135                 7140             


Asp Asp  Glu Asn Leu Gln Thr  Ser Phe Val Asp Asn  Val Ala Thr 
    7145                 7150                 7155             


Leu Lys  Ile Leu Gln Thr Asp  Leu Ser His Ser Gly  Gln Tyr Ser 
    7160                 7165                 7170             


Cys Ser  Ala Ser Asn Pro Leu  Gly Thr Ala Ser Ser  Ser Ala Arg 
    7175                 7180                 7185             


Leu Thr  Ala Arg Glu Pro Lys  Lys Ser Pro Phe Phe  Asp Ile Lys 
    7190                 7195                 7200             


Pro Val  Ser Ile Asp Val Ile  Ala Gly Glu Ser Ala  Asp Phe Glu 
    7205                 7210                 7215             


Cys His  Val Thr Gly Ala Gln  Pro Met Arg Ile Thr  Trp Ser Lys 
    7220                 7225                 7230             


Asp Asn  Lys Glu Ile Arg Pro  Gly Gly Asn Tyr Thr  Ile Thr Cys 
    7235                 7240                 7245             


Val Gly  Asn Thr Pro His Leu  Arg Ile Leu Lys Val  Gly Lys Gly 
    7250                 7255                 7260             


Asp Ser  Gly Gln Tyr Thr Cys  Gln Ala Thr Asn Asp  Val Gly Lys 
    7265                 7270                 7275             


Asp Met  Cys Ser Ala Gln Leu  Ser Val Lys Glu Pro  Pro Lys Phe 
    7280                 7285                 7290             


Val Lys  Lys Leu Glu Ala Ser  Lys Val Ala Lys Gln  Gly Glu Ser 
    7295                 7300                 7305             


Ile Gln  Leu Glu Cys Lys Ile  Ser Gly Ser Pro Glu  Ile Lys Val 
    7310                 7315                 7320             


Ser Trp  Phe Arg Asn Asp Ser  Glu Leu His Glu Ser  Trp Lys Tyr 
    7325                 7330                 7335             


Asn Met  Ser Phe Ile Asn Ser  Val Ala Leu Leu Thr  Ile Asn Glu 
    7340                 7345                 7350             


Ala Ser  Ala Glu Asp Ser Gly  Asp Tyr Ile Cys Glu  Ala His Asn 
    7355                 7360                 7365             


Gly Val  Gly Asp Ala Ser Cys  Ser Thr Ala Leu Thr  Val Lys Ala 
    7370                 7375                 7380             


Pro Pro  Val Phe Thr Gln Lys  Pro Ser Pro Val Gly  Ala Leu Lys 
    7385                 7390                 7395             


Gly Ser  Asp Val Ile Leu Gln  Cys Glu Ile Ser Gly  Thr Pro Pro 
    7400                 7405                 7410             


Phe Glu  Val Val Trp Val Lys  Asp Arg Lys Gln Val  Arg Asn Ser 
    7415                 7420                 7425             


Lys Lys  Phe Lys Ile Thr Ser  Lys His Phe Asp Thr  Ser Leu His 
    7430                 7435                 7440             


Ile Leu  Asn Leu Glu Ala Ser  Asp Val Gly Glu Tyr  His Cys Lys 
    7445                 7450                 7455             


Ala Thr  Asn Glu Val Gly Ser  Asp Thr Cys Ser Cys  Ser Val Lys 
    7460                 7465                 7470             


Phe Lys  Glu Pro Pro Arg Phe  Val Lys Lys Leu Ser  Asp Thr Ser 
    7475                 7480                 7485             


Thr Leu  Ile Gly Asp Ala Val  Glu Leu Arg Ala Ile  Val Glu Gly 
    7490                 7495                 7500             


Phe Gln  Pro Ile Ser Val Val  Trp Leu Lys Asp Arg  Gly Glu Val 
    7505                 7510                 7515             


Ile Arg  Glu Ser Glu Asn Thr  Arg Ile Ser Phe Ile  Asp Asn Ile 
    7520                 7525                 7530             


Ala Thr  Leu Gln Leu Gly Ser  Pro Glu Ala Ser Asn  Ser Gly Lys 
    7535                 7540                 7545             


Tyr Ile  Cys Gln Ile Lys Asn  Asp Ala Gly Met Arg  Glu Cys Ser 
    7550                 7555                 7560             


Ala Val  Leu Thr Val Leu Glu  Pro Ala Arg Ile Ile  Glu Lys Pro 
    7565                 7570                 7575             


Glu Pro  Met Thr Val Thr Thr  Gly Asn Pro Phe Ala  Leu Glu Cys 
    7580                 7585                 7590             


Val Val  Thr Gly Thr Pro Glu  Leu Ser Ala Lys Trp  Phe Lys Asp 
    7595                 7600                 7605             


Gly Arg  Glu Leu Ser Ala Asp  Ser Lys His His Ile  Thr Phe Ile 
    7610                 7615                 7620             


Asn Lys  Val Ala Ser Leu Lys  Ile Pro Cys Ala Glu  Met Ser Asp 
    7625                 7630                 7635             


Lys Gly  Leu Tyr Ser Phe Glu  Val Lys Asn Ser Val  Gly Lys Ser 
    7640                 7645                 7650             


Asn Cys  Thr Val Ser Val His  Val Ser Asp Arg Ile  Val Pro Pro 
    7655                 7660                 7665             


Ser Phe  Ile Arg Lys Leu Lys  Asp Val Asn Ala Ile  Leu Gly Ala 
    7670                 7675                 7680             


Ser Val  Val Leu Glu Cys Arg  Val Ser Gly Ser Ala  Pro Ile Ser 
    7685                 7690                 7695             


Val Gly  Trp Phe Gln Asp Gly  Asn Glu Ile Val Ser  Gly Pro Lys 
    7700                 7705                 7710             


Cys Gln  Ser Ser Phe Ser Glu  Asn Val Cys Thr Leu  Asn Leu Ser 
    7715                 7720                 7725             


Leu Leu  Glu Pro Ser Asp Thr  Gly Ile Tyr Thr Cys  Val Ala Ala 
    7730                 7735                 7740             


Asn Val  Ala Gly Ser Asp Glu  Cys Ser Ala Val Leu  Thr Val Gln 
    7745                 7750                 7755             


Glu Pro  Pro Ser Phe Glu Gln  Thr Pro Asp Ser Val  Glu Val Leu 
    7760                 7765                 7770             


Pro Gly  Met Ser Leu Thr Phe  Thr Ser Val Ile Arg  Gly Thr Pro 
    7775                 7780                 7785             


Pro Phe  Lys Val Lys Trp Phe  Lys Gly Ser Arg Glu  Leu Val Pro 
    7790                 7795                 7800             


Gly Glu  Ser Cys Asn Ile Ser  Leu Glu Asp Phe Val  Thr Glu Leu 
    7805                 7810                 7815             


Glu Leu  Phe Glu Val Gln Pro  Leu Glu Ser Gly Asp  Tyr Ser Cys 
    7820                 7825                 7830             


Leu Val  Thr Asn Asp Ala Gly  Ser Ala Ser Cys Thr  Thr His Leu 
    7835                 7840                 7845             


Phe Val  Lys Glu Pro Ala Thr  Phe Val Lys Arg Leu  Ala Asp Phe 
    7850                 7855                 7860             


Ser Val  Glu Thr Gly Ser Pro  Ile Val Leu Glu Ala  Thr Tyr Thr 
    7865                 7870                 7875             


Gly Thr  Pro Pro Ile Ser Val  Ser Trp Ile Lys Asp  Glu Tyr Leu 
    7880                 7885                 7890             


Ile Ser  Gln Ser Glu Arg Cys  Ser Ile Thr Met Thr  Glu Lys Ser 
    7895                 7900                 7905             


Thr Ile  Leu Glu Ile Leu Glu  Ser Thr Ile Glu Asp  Tyr Ala Gln 
    7910                 7915                 7920             


Tyr Ser  Cys Leu Ile Glu Asn  Glu Ala Gly Gln Asp  Ile Cys Glu 
    7925                 7930                 7935             


Ala Leu  Val Ser Val Leu Glu  Pro Pro Tyr Phe Ile  Glu Pro Leu 
    7940                 7945                 7950             


Glu His  Val Glu Ala Val Ile  Gly Glu Pro Ala Thr  Leu Gln Cys 
    7955                 7960                 7965             


Lys Val  Asp Gly Thr Pro Glu  Ile Arg Ile Ser Trp  Tyr Lys Glu 
    7970                 7975                 7980             


His Thr  Lys Leu Arg Ser Ala  Pro Ala Tyr Lys Met  Gln Phe Lys 
    7985                 7990                 7995             


Asn Asn  Val Ala Ser Leu Val  Ile Asn Lys Val Asp  His Ser Asp 
    8000                 8005                 8010             


Val Gly  Glu Tyr Ser Cys Lys  Ala Asp Asn Ser Val  Gly Ala Val 
    8015                 8020                 8025             


Ala Ser  Ser Ala Val Leu Val  Ile Lys Ala Arg Lys  Leu Pro Pro 
    8030                 8035                 8040             


Phe Phe  Ala Arg Lys Leu Lys  Asp Val His Glu Thr  Leu Gly Phe 
    8045                 8050                 8055             


Pro Val  Ala Phe Glu Cys Arg  Ile Asn Gly Ser Glu  Pro Leu Gln 
    8060                 8065                 8070             


Val Ser  Trp Tyr Lys Asp Gly  Val Leu Leu Lys Asp  Asp Ala Asn 
    8075                 8080                 8085             


Leu Gln  Thr Ser Phe Val His  Asn Val Ala Thr Leu  Gln Ile Leu 
    8090                 8095                 8100             


Gln Thr  Asp Gln Ser His Ile  Gly Gln Tyr Asn Cys  Ser Ala Ser 
    8105                 8110                 8115             


Asn Pro  Leu Gly Thr Ala Ser  Ser Ser Ala Lys Leu  Ile Leu Ser 
    8120                 8125                 8130             


Glu His  Glu Val Pro Pro Phe  Phe Asp Leu Lys Pro  Val Ser Val 
    8135                 8140                 8145             


Asp Leu  Ala Leu Gly Glu Ser  Gly Thr Phe Lys Cys  His Val Thr 
    8150                 8155                 8160             


Gly Thr  Ala Pro Ile Lys Ile  Thr Trp Ala Lys Asp  Asn Arg Glu 
    8165                 8170                 8175             


Ile Arg  Pro Gly Gly Asn Tyr  Lys Met Thr Leu Val  Glu Asn Thr 
    8180                 8185                 8190             


Ala Thr  Leu Thr Val Leu Lys  Val Gly Lys Gly Asp  Ala Gly Gln 
    8195                 8200                 8205             


Tyr Thr  Cys Tyr Ala Ser Asn  Ile Ala Gly Lys Asp  Ser Cys Ser 
    8210                 8215                 8220             


Ala Gln  Leu Gly Val Gln Glu  Pro Pro Arg Phe Ile  Lys Lys Leu 
    8225                 8230                 8235             


Glu Pro  Ser Arg Ile Val Lys  Gln Asp Glu Phe Thr  Arg Tyr Glu 
    8240                 8245                 8250             


Cys Lys  Ile Gly Gly Ser Pro  Glu Ile Lys Val Leu  Trp Tyr Lys 
    8255                 8260                 8265             


Asp Glu  Thr Glu Ile Gln Glu  Ser Ser Lys Phe Arg  Met Ser Phe 
    8270                 8275                 8280             


Val Asp  Ser Val Ala Val Leu  Glu Met His Asn Leu  Ser Val Glu 
    8285                 8290                 8295             


Asp Ser  Gly Asp Tyr Thr Cys  Glu Ala His Asn Ala  Ala Gly Ser 
    8300                 8305                 8310             


Ala Ser  Ser Ser Thr Ser Leu  Lys Val Lys Glu Pro  Pro Ile Phe 
    8315                 8320                 8325             


Arg Lys  Lys Pro His Pro Ile  Glu Thr Leu Lys Gly  Ala Asp Val 
    8330                 8335                 8340             


His Leu  Glu Cys Glu Leu Gln  Gly Thr Pro Pro Phe  His Val Ser 
    8345                 8350                 8355             


Trp Tyr  Lys Asp Lys Arg Glu  Leu Arg Ser Gly Lys  Lys Tyr Lys 
    8360                 8365                 8370             


Ile Met  Ser Glu Asn Phe Leu  Thr Ser Ile His Ile  Leu Asn Val 
    8375                 8380                 8385             


Asp Ala  Ala Asp Ile Gly Glu  Tyr Gln Cys Lys Ala  Thr Asn Asp 
    8390                 8395                 8400             


Val Gly  Ser Asp Thr Cys Val  Gly Ser Ile Ala Leu  Lys Ala Pro 
    8405                 8410                 8415             


Pro Arg  Phe Val Lys Lys Leu  Ser Asp Ile Ser Thr  Val Val Gly 
    8420                 8425                 8430             


Lys Glu  Val Gln Leu Gln Thr  Thr Ile Glu Gly Ala  Glu Pro Ile 
    8435                 8440                 8445             


Ser Val  Val Trp Phe Lys Asp  Lys Gly Glu Ile Val  Arg Glu Ser 
    8450                 8455                 8460             


Asp Asn  Ile Trp Ile Ser Tyr  Ser Glu Asn Ile Ala  Thr Leu Gln 
    8465                 8470                 8475             


Phe Ser  Arg Val Glu Pro Ala  Asn Ala Gly Lys Tyr  Thr Cys Gln 
    8480                 8485                 8490             


Ile Lys  Asn Asp Ala Gly Met  Gln Glu Cys Phe Ala  Thr Leu Ser 
    8495                 8500                 8505             


Val Leu  Glu Pro Ala Thr Ile  Val Glu Lys Pro Glu  Ser Ile Lys 
    8510                 8515                 8520             


Val Thr  Thr Gly Asp Thr Cys  Thr Leu Glu Cys Thr  Val Ala Gly 
    8525                 8530                 8535             


Thr Pro  Glu Leu Ser Thr Lys  Trp Phe Lys Asp Gly  Lys Glu Leu 
    8540                 8545                 8550             


Thr Ser  Asp Asn Lys Tyr Lys  Ile Ser Phe Phe Asn  Lys Val Ser 
    8555                 8560                 8565             


Gly Leu  Lys Ile Ile Asn Val  Ala Pro Ser Asp Ser  Gly Val Tyr 
    8570                 8575                 8580             


Ser Phe  Glu Val Gln Asn Pro  Val Gly Lys Asp Ser  Cys Thr Ala 
    8585                 8590                 8595             


Ser Leu  Gln Val Ser Asp Arg  Thr Val Pro Pro Ser  Phe Thr Arg 
    8600                 8605                 8610             


Lys Leu  Lys Glu Thr Asn Gly  Leu Ser Gly Ser Ser  Val Val Met 
    8615                 8620                 8625             


Glu Cys  Lys Val Tyr Gly Ser  Pro Pro Ile Ser Val  Ser Trp Phe 
    8630                 8635                 8640             


His Glu  Gly Asn Glu Ile Ser  Ser Gly Arg Lys Tyr  Gln Thr Thr 
    8645                 8650                 8655             


Leu Thr  Asp Asn Thr Cys Ala  Leu Thr Val Asn Met  Leu Glu Glu 
    8660                 8665                 8670             


Ser Asp  Ser Gly Asp Tyr Thr  Cys Ile Ala Thr Asn  Met Ala Gly 
    8675                 8680                 8685             


Ser Asp  Glu Cys Ser Ala Pro  Leu Thr Val Arg Glu  Pro Pro Ser 
    8690                 8695                 8700             


Phe Val  Gln Lys Pro Asp Pro  Met Asp Val Leu Thr  Gly Thr Asn 
    8705                 8710                 8715             


Val Thr  Phe Thr Ser Ile Val  Lys Gly Thr Pro Pro  Phe Ser Val 
    8720                 8725                 8730             


Ser Trp  Phe Lys Gly Ser Ser  Glu Leu Val Pro Gly  Asp Arg Cys 
    8735                 8740                 8745             


Asn Val  Ser Leu Glu Asp Ser  Val Ala Glu Leu Glu  Leu Phe Asp 
    8750                 8755                 8760             


Val Asp  Thr Ser Gln Ser Gly  Glu Tyr Thr Cys Ile  Val Ser Asn 
    8765                 8770                 8775             


Glu Ala  Gly Lys Ala Ser Cys  Thr Thr His Leu Tyr  Ile Lys Ala 
    8780                 8785                 8790             


Pro Ala  Lys Phe Val Lys Arg  Leu Asn Asp Tyr Ser  Ile Glu Lys 
    8795                 8800                 8805             


Gly Lys  Pro Leu Ile Leu Glu  Gly Thr Phe Thr Gly  Thr Pro Pro 
    8810                 8815                 8820             


Ile Ser  Val Thr Trp Lys Lys  Asn Gly Ile Asn Val  Thr Pro Ser 
    8825                 8830                 8835             


Gln Arg  Cys Asn Ile Thr Thr  Thr Glu Lys Ser Ala  Ile Leu Glu 
    8840                 8845                 8850             


Ile Pro  Ser Ser Thr Val Glu  Asp Ala Gly Gln Tyr  Asn Cys Tyr 
    8855                 8860                 8865             


Ile Glu  Asn Ala Ser Gly Lys  Asp Ser Cys Ser Ala  Gln Ile Leu 
    8870                 8875                 8880             


Ile Leu  Glu Pro Pro Tyr Phe  Val Lys Gln Leu Glu  Pro Val Lys 
    8885                 8890                 8895             


Val Ser  Val Gly Asp Ser Ala  Ser Leu Gln Cys Gln  Leu Ala Gly 
    8900                 8905                 8910             


Thr Pro  Glu Ile Gly Val Ser  Trp Tyr Lys Gly Asp  Thr Lys Leu 
    8915                 8920                 8925             


Arg Pro  Thr Thr Thr Tyr Lys  Met His Phe Arg Asn  Asn Val Ala 
    8930                 8935                 8940             


Thr Leu  Val Phe Asn Gln Val  Asp Ile Asn Asp Ser  Gly Glu Tyr 
    8945                 8950                 8955             


Ile Cys  Lys Ala Glu Asn Ser  Val Gly Glu Val Ser  Ala Ser Thr 
    8960                 8965                 8970             


Phe Leu  Thr Val Gln Glu Gln  Lys Leu Pro Pro Ser  Phe Ser Arg 
    8975                 8980                 8985             


Gln Leu  Arg Asp Val Gln Glu  Thr Val Gly Leu Pro  Val Val Phe 
    8990                 8995                 9000             


Asp Cys  Ala Ile Ser Gly Ser  Glu Pro Ile Ser Val  Ser Trp Tyr 
    9005                 9010                 9015             


Lys Asp  Gly Lys Pro Leu Lys  Asp Ser Pro Asn Val  Gln Thr Ser 
    9020                 9025                 9030             


Phe Leu  Asp Asn Thr Ala Thr  Leu Asn Ile Phe Lys  Thr Asp Arg 
    9035                 9040                 9045             


Ser Leu  Ala Gly Gln Tyr Ser  Cys Thr Ala Thr Asn  Pro Ile Gly 
    9050                 9055                 9060             


Ser Ala  Ser Ser Ser Ala Arg  Leu Ile Leu Thr Glu  Gly Lys Asn 
    9065                 9070                 9075             


Pro Pro  Phe Phe Asp Ile Arg  Leu Ala Pro Val Asp  Ala Val Val 
    9080                 9085                 9090             


Gly Glu  Ser Ala Asp Phe Glu  Cys His Val Thr Gly  Thr Gln Pro 
    9095                 9100                 9105             


Ile Lys  Val Ser Trp Ala Lys  Asp Ser Arg Glu Ile  Arg Ser Gly 
    9110                 9115                 9120             


Gly Lys  Tyr Gln Ile Ser Tyr  Leu Glu Asn Ser Ala  His Leu Thr 
    9125                 9130                 9135             


Val Leu  Lys Val Asp Lys Gly  Asp Ser Gly Gln Tyr  Thr Cys Tyr 
    9140                 9145                 9150             


Ala Val  Asn Glu Val Gly Lys  Asp Ser Cys Thr Ala  Gln Leu Asn 
    9155                 9160                 9165             


Ile Lys  Glu Arg Leu Ile Pro  Pro Ser Phe Thr Lys  Arg Leu Ser 
    9170                 9175                 9180             


Glu Thr  Val Glu Glu Thr Glu  Gly Asn Ser Phe Lys  Leu Glu Gly 
    9185                 9190                 9195             


Arg Val  Ala Gly Ser Gln Pro  Ile Thr Val Ala Trp  Tyr Lys Asn 
    9200                 9205                 9210             


Asn Ile  Glu Ile Gln Pro Thr  Ser Asn Cys Glu Ile  Thr Phe Lys 
    9215                 9220                 9225             


Asn Asn  Thr Leu Val Leu Gln  Val Arg Lys Ala Gly  Met Asn Asp 
    9230                 9235                 9240             


Ala Gly  Leu Tyr Thr Cys Lys  Val Ser Asn Asp Ala  Gly Ser Ala 
    9245                 9250                 9255             


Leu Cys  Thr Ser Ser Ile Val  Ile Lys Glu Pro Lys  Lys Pro Pro 
    9260                 9265                 9270             


Val Phe  Asp Gln His Leu Thr  Pro Val Thr Val Ser  Glu Gly Glu 
    9275                 9280                 9285             


Tyr Val  Gln Leu Ser Cys His  Val Gln Gly Ser Glu  Pro Ile Arg 
    9290                 9295                 9300             


Ile Gln  Trp Leu Lys Ala Gly  Arg Glu Ile Lys Pro  Ser Asp Arg 
    9305                 9310                 9315             


Cys Ser  Phe Ser Phe Ala Ser  Gly Thr Ala Val Leu  Glu Leu Arg 
    9320                 9325                 9330             


Asp Val  Ala Lys Ala Asp Ser  Gly Asp Tyr Val Cys  Lys Ala Ser 
    9335                 9340                 9345             


Asn Val  Ala Gly Ser Asp Thr  Thr Lys Ser Lys Val  Thr Ile Lys 
    9350                 9355                 9360             


Asp Lys  Pro Ala Val Ala Pro  Ala Thr Lys Lys Ala  Ala Val Asp 
    9365                 9370                 9375             


Gly Arg  Leu Phe Phe Val Ser  Glu Pro Gln Ser Ile  Arg Val Val 
    9380                 9385                 9390             


Glu Lys  Thr Thr Ala Thr Phe  Ile Ala Lys Val Gly  Gly Asp Pro 
    9395                 9400                 9405             


Ile Pro  Asn Val Lys Trp Thr  Lys Gly Lys Trp Arg  Gln Leu Asn 
    9410                 9415                 9420             


Gln Gly  Gly Arg Val Phe Ile  His Gln Lys Gly Asp  Glu Ala Lys 
    9425                 9430                 9435             


Leu Glu  Ile Arg Asp Thr Thr  Lys Thr Asp Ser Gly  Leu Tyr Arg 
    9440                 9445                 9450             


Cys Val  Ala Phe Asn Glu His  Gly Glu Ile Glu Ser  Asn Val Asn 
    9455                 9460                 9465             


Leu Gln  Val Asp Glu Arg Lys  Lys Gln Glu Lys Ile  Glu Gly Asp 
    9470                 9475                 9480             


Leu Arg  Ala Met Leu Lys Lys  Thr Pro Ile Leu Lys  Lys Gly Ala 
    9485                 9490                 9495             


Gly Glu  Glu Glu Glu Ile Asp  Ile Met Glu Leu Leu  Lys Asn Val 
    9500                 9505                 9510             


Asp Pro  Lys Glu Tyr Glu Lys  Tyr Ala Arg Met Tyr  Gly Ile Thr 
    9515                 9520                 9525             


Asp Phe  Arg Gly Leu Leu Gln  Ala Phe Glu Leu Leu  Lys Gln Ser 
    9530                 9535                 9540             


Gln Glu  Glu Glu Thr His Arg  Leu Glu Ile Glu Glu  Ile Glu Arg 
    9545                 9550                 9555             


Ser Glu  Arg Asp Glu Lys Glu  Phe Glu Glu Leu Val  Ser Phe Ile 
    9560                 9565                 9570             


Gln Gln  Arg Leu Ser Gln Thr  Glu Pro Val Thr Leu  Ile Lys Asp 
    9575                 9580                 9585             


Ile Glu  Asn Gln Thr Val Leu  Lys Asp Asn Asp Ala  Val Phe Glu 
    9590                 9595                 9600             


Ile Asp  Ile Lys Ile Asn Tyr  Pro Glu Ile Lys Leu  Ser Trp Tyr 
    9605                 9610                 9615             


Lys Gly  Thr Glu Lys Leu Glu  Pro Ser Asp Lys Phe  Glu Ile Ser 
    9620                 9625                 9630             


Ile Asp  Gly Asp Arg His Thr  Leu Arg Val Lys Asn  Cys Gln Leu 
    9635                 9640                 9645             


Lys Asp  Gln Gly Asn Tyr Arg  Leu Val Cys Gly Pro  His Ile Ala 
    9650                 9655                 9660             


Ser Ala  Lys Leu Thr Val Ile  Glu Pro Ala Trp Glu  Arg His Leu 
    9665                 9670                 9675             


Gln Asp  Val Thr Leu Lys Glu  Gly Gln Thr Cys Thr  Met Thr Cys 
    9680                 9685                 9690             


Gln Phe  Ser Val Pro Asn Val  Lys Ser Glu Trp Phe  Arg Asn Gly 
    9695                 9700                 9705             


Arg Ile  Leu Lys Pro Gln Gly  Arg His Lys Thr Glu  Val Glu His 
    9710                 9715                 9720             


Lys Val  His Lys Leu Thr Ile  Ala Asp Val Arg Ala  Glu Asp Gln 
    9725                 9730                 9735             


Gly Gln  Tyr Thr Cys Lys Tyr  Glu Asp Leu Glu Thr  Ser Ala Glu 
    9740                 9745                 9750             


Leu Arg  Ile Glu Ala Glu Pro  Ile Gln Phe Thr Lys  Arg Ile Gln 
    9755                 9760                 9765             


Asn Ile  Val Val Ser Glu His  Gln Ser Ala Thr Phe  Glu Cys Glu 
    9770                 9775                 9780             


Val Ser  Phe Asp Asp Ala Ile  Val Thr Trp Tyr Lys  Gly Pro Thr 
    9785                 9790                 9795             


Glu Leu  Thr Glu Ser Gln Lys  Tyr Asn Phe Arg Asn  Asp Gly Arg 
    9800                 9805                 9810             


Cys His  Tyr Met Thr Ile His  Asn Val Thr Pro Asp  Asp Glu Gly 
    9815                 9820                 9825             


Val Tyr  Ser Val Ile Ala Arg  Leu Glu Pro Arg Gly  Glu Ala Arg 
    9830                 9835                 9840             


Ser Thr  Ala Glu Leu Tyr Leu  Thr Thr Lys Glu Ile  Lys Leu Glu 
    9845                 9850                 9855             


Leu Lys  Pro Pro Asp Ile Pro  Asp Ser Arg Val Pro  Ile Pro Thr 
    9860                 9865                 9870             


Met Pro  Ile Arg Ala Val Pro  Pro Glu Glu Ile Pro  Pro Val Val 
    9875                 9880                 9885             


Ala Pro  Pro Ile Pro Leu Leu  Leu Pro Thr Pro Glu  Glu Lys Lys 
    9890                 9895                 9900             


Pro Pro  Pro Lys Arg Ile Glu  Val Thr Lys Lys Ala  Val Lys Lys 
    9905                 9910                 9915             


Asp Ala  Lys Lys Val Val Ala  Lys Pro Lys Glu Met  Thr Pro Arg 
    9920                 9925                 9930             


Glu Glu  Ile Val Lys Lys Pro  Pro Pro Pro Thr Thr  Leu Ile Pro 
    9935                 9940                 9945             


Ala Lys  Ala Pro Glu Ile Ile  Asp Val Ser Ser Lys  Ala Glu Glu 
    9950                 9955                 9960             


Val Lys  Ile Met Thr Ile Thr  Arg Lys Lys Glu Val  Gln Lys Glu 
    9965                 9970                 9975             


Lys Glu  Ala Val Tyr Glu Lys  Lys Gln Ala Val His  Lys Glu Lys 
    9980                 9985                 9990             


Arg Val  Phe Ile Glu Ser Phe   Glu Glu Pro Tyr Asp   Glu Leu Glu 
    9995                 10000                 10005             


Val Glu   Pro Tyr Thr Glu Pro   Phe Glu Gln Pro Tyr   Tyr Glu Glu 
    10010                 10015                 10020             


Pro Asp   Glu Asp Tyr Glu Glu   Ile Lys Val Glu Ala   Lys Lys Glu 
    10025                 10030                 10035             


Val His   Glu Glu Trp Glu Glu   Asp Phe Glu Glu Gly   Gln Glu Tyr 
    10040                 10045                 10050             


Tyr Glu   Arg Glu Glu Gly Tyr   Asp Glu Gly Glu Glu   Glu Trp Glu 
    10055                 10060                 10065             


Glu Ala   Tyr Gln Glu Arg Glu   Val Ile Gln Val Gln   Lys Glu Val 
    10070                 10075                 10080             


Tyr Glu   Glu Ser His Glu Arg   Lys Val Pro Ala Lys   Val Pro Glu 
    10085                 10090                 10095             


Lys Lys   Ala Pro Pro Pro Pro   Lys Val Ile Lys Lys   Pro Val Ile 
    10100                 10105                 10110             


Glu Lys   Ile Glu Lys Thr Ser   Arg Arg Met Glu Glu   Glu Lys Val 
    10115                 10120                 10125             


Gln Val   Thr Lys Val Pro Glu   Val Ser Lys Lys Ile   Val Pro Gln 
    10130                 10135                 10140             


Lys Pro   Ser Arg Thr Pro Val   Gln Glu Glu Val Ile   Glu Val Lys 
    10145                 10150                 10155             


Val Pro   Ala Val His Thr Lys   Lys Met Val Ile Ser   Glu Glu Lys 
    10160                 10165                 10170             


Met Phe   Phe Ala Ser His Thr   Glu Glu Glu Val Ser   Val Thr Val 
    10175                 10180                 10185             


Pro Glu   Val Gln Lys Glu Ile   Val Thr Glu Glu Lys   Ile His Val 
    10190                 10195                 10200             


Ala Ile   Ser Lys Arg Val Glu   Pro Pro Pro Lys Val   Pro Glu Leu 
    10205                 10210                 10215             


Pro Glu   Lys Pro Ala Pro Glu   Glu Val Ala Pro Val   Pro Ile Pro 
    10220                 10225                 10230             


Lys Lys   Val Glu Pro Pro Ala   Pro Lys Val Pro Glu   Val Pro Lys 
    10235                 10240                 10245             


Lys Pro   Val Pro Glu Glu Lys   Lys Pro Val Pro Val   Pro Lys Lys 
    10250                 10255                 10260             


Glu Pro   Ala Ala Pro Pro Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10265                 10270                 10275             


Val Pro   Glu Glu Lys Ile Pro   Val Pro Val Ala Lys   Lys Lys Glu 
    10280                 10285                 10290             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Gln Lys Gly   Val Val Thr 
    10295                 10300                 10305             


Glu Glu   Lys Ile Thr Ile Val   Thr Gln Arg Glu Glu   Ser Pro Pro 
    10310                 10315                 10320             


Pro Ala   Val Pro Glu Ile Pro   Lys Lys Lys Val Pro   Glu Glu Arg 
    10325                 10330                 10335             


Lys Pro   Val Pro Arg Lys Glu   Glu Glu Val Pro Pro   Pro Pro Lys 
    10340                 10345                 10350             


Val Pro   Ala Leu Pro Lys Lys   Pro Val Pro Glu Glu   Lys Val Ala 
    10355                 10360                 10365             


Val Pro   Val Pro Val Ala Lys   Lys Ala Pro Pro Pro   Arg Ala Glu 
    10370                 10375                 10380             


Val Ser   Lys Lys Thr Val Val   Glu Glu Lys Arg Phe   Val Ala Glu 
    10385                 10390                 10395             


Glu Lys   Leu Ser Phe Ala Val   Pro Gln Arg Val Glu   Val Thr Arg 
    10400                 10405                 10410             


His Glu   Val Ser Ala Glu Glu   Glu Trp Ser Tyr Ser   Glu Glu Glu 
    10415                 10420                 10425             


Glu Gly   Val Ser Ile Ser Val   Tyr Arg Glu Glu Glu   Arg Glu Glu 
    10430                 10435                 10440             


Glu Glu   Glu Ala Glu Val Thr   Glu Tyr Glu Val Met   Glu Glu Pro 
    10445                 10450                 10455             


Glu Glu   Tyr Val Val Glu Glu   Lys Leu His Ile Ile   Ser Lys Arg 
    10460                 10465                 10470             


Val Glu   Ala Glu Pro Ala Glu   Val Thr Glu Arg Gln   Glu Lys Lys 
    10475                 10480                 10485             


Ile Val   Leu Lys Pro Lys Ile   Pro Ala Lys Ile Glu   Glu Pro Pro 
    10490                 10495                 10500             


Pro Ala   Lys Val Pro Glu Ala   Pro Lys Lys Ile Val   Pro Glu Lys 
    10505                 10510                 10515             


Lys Val   Pro Ala Pro Val Pro   Lys Lys Glu Lys Val   Pro Pro Pro 
    10520                 10525                 10530             


Lys Val   Pro Glu Glu Pro Lys   Lys Pro Val Pro Glu   Lys Lys Val 
    10535                 10540                 10545             


Pro Pro   Lys Val Ile Lys Met   Glu Glu Pro Leu Pro   Ala Lys Val 
    10550                 10555                 10560             


Thr Glu   Arg His Met Gln Ile   Thr Gln Glu Glu Lys   Val Leu Val 
    10565                 10570                 10575             


Ala Val   Thr Lys Lys Glu Ala   Pro Pro Lys Ala Arg   Val Pro Glu 
    10580                 10585                 10590             


Glu Pro   Lys Arg Ala Val Pro   Glu Glu Lys Val Leu   Lys Leu Lys 
    10595                 10600                 10605             


Pro Lys   Arg Glu Glu Glu Pro   Pro Ala Lys Val Thr   Glu Phe Arg 
    10610                 10615                 10620             


Lys Arg   Val Val Lys Glu Glu   Lys Val Ser Ile Glu   Ala Pro Lys 
    10625                 10630                 10635             


Arg Glu   Pro Gln Pro Ile Lys   Glu Val Thr Ile Met   Glu Glu Lys 
    10640                 10645                 10650             


Glu Arg   Ala Tyr Thr Leu Glu   Glu Glu Ala Val Ser   Val Gln Arg 
    10655                 10660                 10665             


Glu Glu   Glu Tyr Glu Glu Tyr   Glu Glu Tyr Asp Tyr   Lys Glu Phe 
    10670                 10675                 10680             


Glu Glu   Tyr Glu Pro Thr Glu   Glu Tyr Asp Gln Tyr   Glu Glu Tyr 
    10685                 10690                 10695             


Glu Glu   Arg Glu Tyr Glu Arg   Tyr Glu Glu His Glu   Glu Tyr Ile 
    10700                 10705                 10710             


Thr Glu   Pro Glu Lys Pro Ile   Pro Val Lys Pro Val   Pro Glu Glu 
    10715                 10720                 10725             


Pro Val   Pro Thr Lys Pro Lys   Ala Pro Pro Ala Lys   Val Leu Lys 
    10730                 10735                 10740             


Lys Ala   Val Pro Glu Glu Lys   Val Pro Val Pro Ile   Pro Lys Lys 
    10745                 10750                 10755             


Leu Lys   Pro Pro Pro Pro Lys   Val Pro Glu Glu Pro   Lys Lys Val 
    10760                 10765                 10770             


Phe Glu   Glu Lys Ile Arg Ile   Ser Ile Thr Lys Arg   Glu Lys Glu 
    10775                 10780                 10785             


Gln Val   Thr Glu Pro Ala Ala   Lys Val Pro Met Lys   Pro Lys Arg 
    10790                 10795                 10800             


Val Val   Ala Glu Glu Lys Val   Pro Val Pro Arg Lys   Glu Val Ala 
    10805                 10810                 10815             


Pro Pro   Val Arg Val Pro Glu   Val Pro Lys Glu Leu   Glu Pro Glu 
    10820                 10825                 10830             


Glu Val   Ala Phe Glu Glu Glu   Val Val Thr His Val   Glu Glu Tyr 
    10835                 10840                 10845             


Leu Val   Glu Glu Glu Glu Glu   Tyr Ile His Glu Glu   Glu Glu Phe 
    10850                 10855                 10860             


Ile Thr   Glu Glu Glu Val Val   Pro Val Ile Pro Val   Lys Val Pro 
    10865                 10870                 10875             


Glu Val   Pro Arg Lys Pro Val   Pro Glu Glu Lys Lys   Pro Val Pro 
    10880                 10885                 10890             


Val Pro   Lys Lys Lys Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val 
    10895                 10900                 10905             


Pro Lys   Lys Pro Glu Glu Lys   Val Pro Val Leu Ile   Pro Lys Lys 
    10910                 10915                 10920             


Glu Lys   Pro Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10925                 10930                 10935             


Val Pro   Glu Glu Lys Val Pro   Val Pro Val Pro Lys   Lys Val Glu 
    10940                 10945                 10950             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Pro Val Pro 
    10955                 10960                 10965             


Glu Lys   Lys Val Pro Val Pro   Ala Pro Lys Lys Val   Glu Ala Pro 
    10970                 10975                 10980             


Pro Ala   Lys Val Pro Glu Val   Pro Lys Lys Leu Ile   Pro Glu Glu 
    10985                 10990                 10995             


Lys Lys   Pro Thr Pro Val Pro   Lys Lys Val Glu Ala   Pro Pro Pro 
    11000                 11005                 11010             


Lys Val   Pro Lys Lys Arg Glu   Pro Val Pro Val Pro   Val Ala Leu 
    11015                 11020                 11025             


Pro Gln   Glu Glu Glu Val Leu   Phe Glu Glu Glu Ile   Val Pro Glu 
    11030                 11035                 11040             


Glu Glu   Val Leu Pro Glu Glu   Glu Glu Val Leu Pro   Glu Glu Glu 
    11045                 11050                 11055             


Glu Val   Leu Pro Glu Glu Glu   Glu Val Leu Pro Glu   Glu Glu Glu 
    11060                 11065                 11070             


Ile Pro   Pro Glu Glu Glu Glu   Val Pro Pro Glu Glu   Glu Tyr Val 
    11075                 11080                 11085             


Pro Glu   Glu Glu Glu Phe Val   Pro Glu Glu Glu Val   Leu Pro Glu 
    11090                 11095                 11100             


Val Lys   Pro Lys Val Pro Val   Pro Ala Pro Val Pro   Glu Ile Lys 
    11105                 11110                 11115             


Lys Lys   Val Thr Glu Lys Lys   Val Val Ile Pro Lys   Lys Glu Glu 
    11120                 11125                 11130             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Val Glu Glu 
    11135                 11140                 11145             


Lys Arg   Ile Ile Leu Pro Lys   Glu Glu Glu Val Leu   Pro Val Glu 
    11150                 11155                 11160             


Val Thr   Glu Glu Pro Glu Glu   Glu Pro Ile Ser Glu   Glu Glu Ile 
    11165                 11170                 11175             


Pro Glu   Glu Pro Pro Ser Ile   Glu Glu Val Glu Glu   Val Ala Pro 
    11180                 11185                 11190             


Pro Arg   Val Pro Glu Val Ile   Lys Lys Ala Val Pro   Glu Ala Pro 
    11195                 11200                 11205             


Thr Pro   Val Pro Lys Lys Val   Glu Ala Pro Pro Ala   Lys Val Ser 
    11210                 11215                 11220             


Lys Lys   Ile Pro Glu Glu Lys   Val Pro Val Pro Val   Gln Lys Lys 
    11225                 11230                 11235             


Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val Pro Lys   Lys Val Pro 
    11240                 11245                 11250             


Glu Lys   Lys Val Leu Val Pro   Lys Lys Glu Ala Val   Pro Pro Ala 
    11255                 11260                 11265             


Lys Gly   Arg Thr Val Leu Glu   Glu Lys Val Ser Val   Ala Phe Arg 
    11270                 11275                 11280             


Gln Glu   Val Val Val Lys Glu   Arg Leu Glu Leu Glu   Val Val Glu 
    11285                 11290                 11295             


Ala Glu   Val Glu Glu Ile Pro   Glu Glu Glu Glu Phe   His Glu Val 
    11300                 11305                 11310             


Glu Glu   Tyr Phe Glu Glu Gly   Glu Phe His Glu Val   Glu Glu Phe 
    11315                 11320                 11325             


Ile Lys   Leu Glu Gln His Arg   Val Glu Glu Glu His   Arg Val Glu 
    11330                 11335                 11340             


Lys Val   His Arg Val Ile Glu   Val Phe Glu Ala Glu   Glu Val Glu 
    11345                 11350                 11355             


Val Phe   Glu Lys Pro Lys Ala   Pro Pro Lys Gly Pro   Glu Ile Ser 
    11360                 11365                 11370             


Glu Lys   Ile Ile Pro Pro Lys   Lys Pro Pro Thr Lys   Val Val Pro 
    11375                 11380                 11385             


Arg Lys   Glu Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Ile 
    11390                 11395                 11400             


Val Val   Glu Glu Lys Val Arg   Val Pro Glu Glu Pro   Arg Val Pro 
    11405                 11410                 11415             


Pro Thr   Lys Val Pro Glu Val   Leu Pro Pro Lys Glu   Val Val Pro 
    11420                 11425                 11430             


Glu Lys   Lys Val Pro Val Pro   Pro Ala Lys Lys Pro   Glu Ala Pro 
    11435                 11440                 11445             


Pro Pro   Lys Val Pro Glu Ala   Pro Lys Glu Val Val   Pro Glu Lys 
    11450                 11455                 11460             


Lys Val   Pro Val Pro Pro Pro   Lys Lys Pro Glu Val   Pro Pro Thr 
    11465                 11470                 11475             


Lys Val   Pro Glu Val Pro Lys   Ala Ala Val Pro Glu   Lys Lys Val 
    11480                 11485                 11490             


Pro Glu   Ala Ile Pro Pro Lys   Pro Glu Ser Pro Pro   Pro Glu Val 
    11495                 11500                 11505             


Pro Glu   Ala Pro Lys Glu Val   Val Pro Glu Lys Lys   Val Pro Ala 
    11510                 11515                 11520             


Ala Pro   Pro Lys Lys Pro Glu   Val Thr Pro Val Lys   Val Pro Glu 
    11525                 11530                 11535             


Ala Pro   Lys Glu Val Val Pro   Glu Lys Lys Val Pro   Val Pro Pro 
    11540                 11545                 11550             


Pro Lys   Lys Pro Glu Val Pro   Pro Thr Lys Val Pro   Glu Val Pro 
    11555                 11560                 11565             


Lys Val   Ala Val Pro Glu Lys   Lys Val Pro Glu Ala   Ile Pro Pro 
    11570                 11575                 11580             


Lys Pro   Glu Ser Pro Pro Pro   Glu Val Phe Glu Glu   Pro Glu Glu 
    11585                 11590                 11595             


Val Ala   Leu Glu Glu Pro Pro   Ala Glu Val Val Glu   Glu Pro Glu 
    11600                 11605                 11610             


Pro Ala   Ala Pro Pro Gln Val   Thr Val Pro Pro Lys   Lys Pro Val 
    11615                 11620                 11625             


Pro Glu   Lys Lys Ala Pro Ala   Val Val Ala Lys Lys   Pro Glu Leu 
    11630                 11635                 11640             


Pro Pro   Val Lys Val Pro Glu   Val Pro Lys Glu Val   Val Pro Glu 
    11645                 11650                 11655             


Lys Lys   Val Pro Leu Val Val   Pro Lys Lys Pro Glu   Ala Pro Pro 
    11660                 11665                 11670             


Ala Lys   Val Pro Glu Val Pro   Lys Glu Val Val Pro   Glu Lys Lys 
    11675                 11680                 11685             


Val Ala   Val Pro Lys Lys Pro   Glu Val Pro Pro Ala   Lys Val Pro 
    11690                 11695                 11700             


Glu Val   Pro Lys Lys Pro Val   Leu Glu Glu Lys Pro   Ala Val Pro 
    11705                 11710                 11715             


Val Pro   Glu Arg Ala Glu Ser   Pro Pro Pro Glu Val   Tyr Glu Glu 
    11720                 11725                 11730             


Pro Glu   Glu Ile Ala Pro Glu   Glu Glu Ile Ala Pro   Glu Glu Glu 
    11735                 11740                 11745             


Lys Pro   Val Pro Val Ala Glu   Glu Glu Glu Pro Glu   Val Pro Pro 
    11750                 11755                 11760             


Pro Ala   Val Pro Glu Glu Pro   Lys Lys Ile Ile Pro   Glu Lys Lys 
    11765                 11770                 11775             


Val Pro   Val Ile Lys Lys Pro   Glu Ala Pro Pro Pro   Lys Glu Pro 
    11780                 11785                 11790             


Glu Pro   Glu Lys Val Ile Glu   Lys Pro Lys Leu Lys   Pro Arg Pro 
    11795                 11800                 11805             


Pro Pro   Pro Pro Pro Ala Pro   Pro Lys Glu Asp Val   Lys Glu Lys 
    11810                 11815                 11820             


Ile Phe   Gln Leu Lys Ala Ile   Pro Lys Lys Lys Val   Pro Glu Lys 
    11825                 11830                 11835             


Pro Gln   Val Pro Glu Lys Val   Glu Leu Thr Pro Leu   Lys Val Pro 
    11840                 11845                 11850             


Gly Gly   Glu Lys Lys Val Arg   Lys Leu Leu Pro Glu   Arg Lys Pro 
    11855                 11860                 11865             


Glu Pro   Lys Glu Glu Val Val   Leu Lys Ser Val Leu   Arg Lys Arg 
    11870                 11875                 11880             


Pro Glu   Glu Glu Glu Pro Lys   Val Glu Pro Lys Lys   Leu Glu Lys 
    11885                 11890                 11895             


Val Lys   Lys Pro Ala Val Pro   Glu Pro Pro Pro Pro   Lys Pro Val 
    11900                 11905                 11910             


Glu Glu   Val Glu Val Pro Thr   Val Thr Lys Arg Glu   Arg Lys Ile 
    11915                 11920                 11925             


Pro Glu   Pro Thr Lys Val Pro   Glu Ile Lys Pro Ala   Ile Pro Leu 
    11930                 11935                 11940             


Pro Ala   Pro Glu Pro Lys Pro   Lys Pro Glu Ala Glu   Val Lys Thr 
    11945                 11950                 11955             


Ile Lys   Pro Pro Pro Val Glu   Pro Glu Pro Thr Pro   Ile Ala Ala 
    11960                 11965                 11970             


Pro Val   Thr Val Pro Val Val   Gly Lys Lys Ala Glu   Ala Lys Ala 
    11975                 11980                 11985             


Pro Lys   Glu Glu Ala Ala Lys   Pro Lys Gly Pro Ile   Lys Gly Val 
    11990                 11995                 12000             


Pro Lys   Lys Thr Pro Ser Pro   Ile Glu Ala Glu Arg   Arg Lys Leu 
    12005                 12010                 12015             


Arg Pro   Gly Ser Gly Gly Glu   Lys Pro Pro Asp Glu   Ala Pro Phe 
    12020                 12025                 12030             


Thr Tyr   Gln Leu Lys Ala Val   Pro Leu Lys Phe Val   Lys Glu Ile 
    12035                 12040                 12045             


Lys Asp   Ile Ile Leu Thr Glu   Ser Glu Phe Val Gly   Ser Ser Ala 
    12050                 12055                 12060             


Ile Phe   Glu Cys Leu Val Ser   Pro Ser Thr Ala Ile   Thr Thr Trp 
    12065                 12070                 12075             


Met Lys   Asp Gly Ser Asn Ile   Arg Glu Ser Pro Lys   His Arg Phe 
    12080                 12085                 12090             


Ile Ala   Asp Gly Lys Asp Arg   Lys Leu His Ile Ile   Asp Val Gln 
    12095                 12100                 12105             


Leu Ser   Asp Ala Gly Glu Tyr   Thr Cys Val Leu Arg   Leu Gly Asn 
    12110                 12115                 12120             


Lys Glu   Lys Thr Ser Thr Ala   Lys Leu Val Val Glu   Glu Leu Pro 
    12125                 12130                 12135             


Val Arg   Phe Val Lys Thr Leu   Glu Glu Glu Val Thr   Val Val Lys 
    12140                 12145                 12150             


Gly Gln   Pro Leu Tyr Leu Ser   Cys Glu Leu Asn Lys   Glu Arg Asp 
    12155                 12160                 12165             


Val Val   Trp Arg Lys Asp Gly   Lys Ile Val Val Glu   Lys Pro Gly 
    12170                 12175                 12180             


Arg Ile   Val Pro Gly Val Ile   Gly Leu Met Arg Ala   Leu Thr Ile 
    12185                 12190                 12195             


Asn Asp   Ala Asp Asp Thr Asp   Ala Gly Thr Tyr Thr   Val Thr Val 
    12200                 12205                 12210             


Glu Asn   Ala Asn Asn Leu Glu   Cys Ser Ser Cys Val   Lys Val Val 
    12215                 12220                 12225             


Glu Val   Ile Arg Asp Trp Leu   Val Lys Pro Ile Arg   Asp Gln His 
    12230                 12235                 12240             


Val Lys   Pro Lys Gly Thr Ala   Ile Phe Ala Cys Asp   Ile Ala Lys 
    12245                 12250                 12255             


Asp Thr   Pro Asn Ile Lys Trp   Phe Lys Gly Tyr Asp   Glu Ile Pro 
    12260                 12265                 12270             


Ala Glu   Pro Asn Asp Lys Thr   Glu Ile Leu Arg Asp   Gly Asn His 
    12275                 12280                 12285             


Leu Tyr   Leu Lys Ile Lys Asn   Ala Met Pro Glu Asp   Ile Ala Glu 
    12290                 12295                 12300             


Tyr Ala   Val Glu Ile Glu Gly   Lys Arg Tyr Pro Ala   Lys Leu Thr 
    12305                 12310                 12315             


Leu Gly   Glu Arg Glu Val Glu   Leu Leu Lys Pro Ile   Glu Asp Val 
    12320                 12325                 12330             


Thr Ile   Tyr Glu Lys Glu Ser   Ala Ser Phe Asp Ala   Glu Ile Ser 
    12335                 12340                 12345             


Glu Ala   Asp Ile Pro Gly Gln   Trp Lys Leu Lys Gly   Glu Leu Leu 
    12350                 12355                 12360             


Arg Pro   Ser Pro Thr Cys Glu   Ile Lys Ala Glu Gly   Gly Lys Arg 
    12365                 12370                 12375             


Phe Leu   Thr Leu His Lys Val   Lys Leu Asp Gln Ala   Gly Glu Val 
    12380                 12385                 12390             


Leu Tyr   Gln Ala Leu Asn Ala   Ile Thr Thr Ala Ile   Leu Thr Val 
    12395                 12400                 12405             


Lys Glu   Ile Glu Leu Asp Phe   Ala Val Pro Leu Lys   Asp Val Thr 
    12410                 12415                 12420             


Val Pro   Glu Arg Arg Gln Ala   Arg Phe Glu Cys Val   Leu Thr Arg 
    12425                 12430                 12435             


Glu Ala   Asn Val Ile Trp Ser   Lys Gly Pro Asp Ile   Ile Lys Ser 
    12440                 12445                 12450             


Ser Asp   Lys Phe Asp Ile Ile   Ala Asp Gly Lys Lys   His Ile Leu 
    12455                 12460                 12465             


Val Ile   Asn Asp Ser Gln Phe   Asp Asp Glu Gly Val   Tyr Thr Ala 
    12470                 12475                 12480             


Glu Val   Glu Gly Lys Lys Thr   Ser Ala Arg Leu Phe   Val Thr Gly 
    12485                 12490                 12495             


Ile Arg   Leu Lys Phe Met Ser   Pro Leu Glu Asp Gln   Thr Val Lys 
    12500                 12505                 12510             


Glu Gly   Glu Thr Ala Thr Phe   Val Cys Glu Leu Ser   His Glu Lys 
    12515                 12520                 12525             


Met His   Val Val Trp Phe Lys   Asn Asp Ala Lys Leu   His Thr Ser 
    12530                 12535                 12540             


Arg Thr   Val Leu Ile Ser Ser   Glu Gly Lys Thr His   Lys Leu Glu 
    12545                 12550                 12555             


Met Lys   Glu Val Thr Leu Asp   Asp Ile Ser Gln Ile   Lys Ala Gln 
    12560                 12565                 12570             


Val Lys   Glu Leu Ser Ser Thr   Ala Gln Leu Lys Val   Leu Glu Ala 
    12575                 12580                 12585             


Asp Pro   Tyr Phe Thr Val Lys   Leu His Asp Lys Thr   Ala Val Glu 
    12590                 12595                 12600             


Lys Asp   Glu Ile Thr Leu Lys   Cys Glu Val Ser Lys   Asp Val Pro 
    12605                 12610                 12615             


Val Lys   Trp Phe Lys Asp Gly   Glu Glu Ile Val Pro   Ser Pro Lys 
    12620                 12625                 12630             


Tyr Ser   Ile Lys Ala Asp Gly   Leu Arg Arg Ile Leu   Lys Ile Lys 
    12635                 12640                 12645             


Lys Ala   Asp Leu Lys Asp Lys   Gly Glu Tyr Val Cys   Asp Cys Gly 
    12650                 12655                 12660             


Thr Asp   Lys Thr Lys Ala Asn   Val Thr Val Glu Ala   Arg Leu Ile 
    12665                 12670                 12675             


Lys Val   Glu Lys Pro Leu Tyr   Gly Val Glu Val Phe   Val Gly Glu 
    12680                 12685                 12690             


Thr Ala   His Phe Glu Ile Glu   Leu Ser Glu Pro Asp   Val His Gly 
    12695                 12700                 12705             


Gln Trp   Lys Leu Lys Gly Gln   Pro Leu Thr Ala Ser   Pro Asp Cys 
    12710                 12715                 12720             


Glu Ile   Ile Glu Asp Gly Lys   Lys His Ile Leu Ile   Leu His Asn 
    12725                 12730                 12735             


Cys Gln   Leu Gly Met Thr Gly   Glu Val Ser Phe Gln   Ala Ala Asn 
    12740                 12745                 12750             


Ala Lys   Ser Ala Ala Asn Leu   Lys Val Lys Glu Leu   Pro Leu Ile 
    12755                 12760                 12765             


Phe Ile   Thr Pro Leu Ser Asp   Val Lys Val Phe Glu   Lys Asp Glu 
    12770                 12775                 12780             


Ala Lys   Phe Glu Cys Glu Val   Ser Arg Glu Pro Lys   Thr Phe Arg 
    12785                 12790                 12795             


Trp Leu   Lys Gly Thr Gln Glu   Ile Thr Gly Asp Asp   Arg Phe Glu 
    12800                 12805                 12810             


Leu Ile   Lys Asp Gly Thr Lys   His Ser Met Val Ile   Lys Ser Ala 
    12815                 12820                 12825             


Ala Phe   Glu Asp Glu Ala Lys   Tyr Met Phe Glu Ala   Glu Asp Lys 
    12830                 12835                 12840             


His Thr   Ser Gly Lys Leu Ile   Ile Glu Gly Ile Arg   Leu Lys Phe 
    12845                 12850                 12855             


Leu Thr   Pro Leu Lys Asp Val   Thr Ala Lys Glu Lys   Glu Ser Ala 
    12860                 12865                 12870             


Val Phe   Thr Val Glu Leu Ser   His Asp Asn Ile Arg   Val Lys Trp 
    12875                 12880                 12885             


Phe Lys   Asn Asp Gln Arg Leu   His Thr Thr Arg Ser   Val Ser Met 
    12890                 12895                 12900             


Gln Asp   Glu Gly Lys Thr His   Ser Ile Thr Phe Lys   Asp Leu Ser 
    12905                 12910                 12915             


Ile Asp   Asp Thr Ser Gln Ile   Arg Val Glu Ala Met   Gly Met Ser 
    12920                 12925                 12930             


Ser Glu   Ala Lys Leu Thr Val   Leu Glu Gly Asp Pro   Tyr Phe Thr 
    12935                 12940                 12945             


Gly Lys   Leu Gln Asp Tyr Thr   Gly Val Glu Lys Asp   Glu Val Ile 
    12950                 12955                 12960             


Leu Gln   Cys Glu Ile Ser Lys   Ala Asp Ala Pro Val   Lys Trp Phe 
    12965                 12970                 12975             


Lys Asp   Gly Lys Glu Ile Lys   Pro Ser Lys Asn Ala   Val Ile Lys 
    12980                 12985                 12990             


Ala Asp   Gly Lys Lys Arg Met   Leu Ile Leu Lys Lys   Ala Leu Lys 
    12995                 13000                 13005             


Ser Asp   Ile Gly Gln Tyr Thr   Cys Asp Cys Gly Thr   Asp Lys Thr 
    13010                 13015                 13020             


Ser Gly   Lys Leu Asp Ile Glu   Asp Arg Glu Ile Lys   Leu Val Arg 
    13025                 13030                 13035             


Pro Leu   His Ser Val Glu Val   Met Glu Thr Glu Thr   Ala Arg Phe 
    13040                 13045                 13050             


Glu Thr   Glu Ile Ser Glu Asp   Asp Ile His Ala Asn   Trp Lys Leu 
    13055                 13060                 13065             


Lys Gly   Glu Ala Leu Leu Gln   Thr Pro Asp Cys Glu   Ile Lys Glu 
    13070                 13075                 13080             


Glu Gly   Lys Ile His Ser Leu   Val Leu His Asn Cys   Arg Leu Asp 
    13085                 13090                 13095             


Gln Thr   Gly Gly Val Asp Phe   Gln Ala Ala Asn Val   Lys Ser Ser 
    13100                 13105                 13110             


Ala His   Leu Arg Val Lys Pro   Arg Val Ile Gly Leu   Leu Arg Pro 
    13115                 13120                 13125             


Leu Lys   Asp Val Thr Val Thr   Ala Gly Glu Thr Ala   Thr Phe Asp 
    13130                 13135                 13140             


Cys Glu   Leu Ser Tyr Glu Asp   Ile Pro Val Glu Trp   Tyr Leu Lys 
    13145                 13150                 13155             


Gly Lys   Lys Leu Glu Pro Ser   Asp Lys Val Val Pro   Arg Ser Glu 
    13160                 13165                 13170             


Gly Lys   Val His Thr Leu Thr   Leu Arg Asp Val Lys   Leu Glu Asp 
    13175                 13180                 13185             


Ala Gly   Glu Val Gln Leu Thr   Ala Lys Asp Phe Lys   Thr His Ala 
    13190                 13195                 13200             


Asn Leu   Phe Val Lys Glu Pro   Pro Val Glu Phe Thr   Lys Pro Leu 
    13205                 13210                 13215             


Glu Asp   Gln Thr Val Glu Glu   Gly Ala Thr Ala Val   Leu Glu Cys 
    13220                 13225                 13230             


Glu Val   Ser Arg Glu Asn Ala   Lys Val Lys Trp Phe   Lys Asn Gly 
    13235                 13240                 13245             


Thr Glu   Ile Leu Lys Ser Lys   Lys Tyr Glu Ile Val   Ala Asp Gly 
    13250                 13255                 13260             


Arg Val   Arg Lys Leu Val Ile   His Asp Cys Thr Pro   Glu Asp Ile 
    13265                 13270                 13275             


Lys Thr   Tyr Thr Cys Asp Ala   Lys Asp Phe Lys Thr   Ser Cys Asn 
    13280                 13285                 13290             


Leu Asn   Val Val Pro Pro His   Val Glu Phe Leu Arg   Pro Leu Thr 
    13295                 13300                 13305             


Asp Leu   Gln Val Arg Glu Lys   Glu Met Ala Arg Phe   Glu Cys Glu 
    13310                 13315                 13320             


Leu Ser   Arg Glu Asn Ala Lys   Val Lys Trp Phe Lys   Asp Gly Ala 
    13325                 13330                 13335             


Glu Ile   Lys Lys Gly Lys Lys   Tyr Asp Ile Ile Ser   Lys Gly Ala 
    13340                 13345                 13350             


Val Arg   Ile Leu Val Ile Asn   Lys Cys Leu Leu Asp   Asp Glu Ala 
    13355                 13360                 13365             


Glu Tyr   Ser Cys Glu Val Arg   Thr Ala Arg Thr Ser   Gly Met Leu 
    13370                 13375                 13380             


Thr Val   Leu Glu Glu Glu Ala   Val Phe Thr Lys Asn   Leu Ala Asn 
    13385                 13390                 13395             


Ile Glu   Val Ser Glu Thr Asp   Thr Ile Lys Leu Val   Cys Glu Val 
    13400                 13405                 13410             


Ser Lys   Pro Gly Ala Glu Val   Ile Trp Tyr Lys Gly   Asp Glu Glu 
    13415                 13420                 13425             


Ile Ile   Glu Thr Gly Arg Tyr   Glu Ile Leu Thr Glu   Gly Arg Lys 
    13430                 13435                 13440             


Arg Ile   Leu Val Ile Gln Asn   Ala His Leu Glu Asp   Ala Gly Asn 
    13445                 13450                 13455             


Tyr Asn   Cys Arg Leu Pro Ser   Ser Arg Thr Asp Gly   Lys Val Lys 
    13460                 13465                 13470             


Val His   Glu Leu Ala Ala Glu   Phe Ile Ser Lys Pro   Gln Asn Leu 
    13475                 13480                 13485             


Glu Ile   Leu Glu Gly Glu Lys   Ala Glu Phe Val Cys   Ser Ile Ser 
    13490                 13495                 13500             


Lys Glu   Ser Phe Pro Val Gln   Trp Lys Arg Asp Asp   Lys Thr Leu 
    13505                 13510                 13515             


Glu Ser   Gly Asp Lys Tyr Asp   Val Ile Ala Asp Gly   Lys Lys Arg 
    13520                 13525                 13530             


Val Leu   Val Val Lys Asp Ala   Thr Leu Gln Asp Met   Gly Thr Tyr 
    13535                 13540                 13545             


Val Val   Met Val Gly Ala Ala   Arg Ala Ala Ala His   Leu Thr Val 
    13550                 13555                 13560             


Ile Glu   Lys Leu Arg Ile Val   Val Pro Leu Lys Asp   Thr Arg Val 
    13565                 13570                 13575             


Lys Glu   Gln Gln Glu Val Val   Phe Asn Cys Glu Val   Asn Thr Glu 
    13580                 13585                 13590             


Gly Ala   Lys Ala Lys Trp Phe   Arg Asn Glu Glu Ala   Ile Phe Asp 
    13595                 13600                 13605             


Ser Ser   Lys Tyr Ile Ile Leu   Gln Lys Asp Leu Val   Tyr Thr Leu 
    13610                 13615                 13620             


Arg Ile   Arg Asp Ala His Leu   Asp Asp Gln Ala Asn   Tyr Asn Val 
    13625                 13630                 13635             


Ser Leu   Thr Asn His Arg Gly   Glu Asn Val Lys Ser   Ala Ala Asn 
    13640                 13645                 13650             


Leu Ile   Val Glu Glu Glu Asp   Leu Arg Ile Val Glu   Pro Leu Lys 
    13655                 13660                 13665             


Asp Ile   Glu Thr Met Glu Lys   Lys Ser Val Thr Phe   Trp Cys Lys 
    13670                 13675                 13680             


Val Asn   Arg Leu Asn Val Thr   Leu Lys Trp Thr Lys   Asn Gly Glu 
    13685                 13690                 13695             


Glu Val   Pro Phe Asp Asn Arg   Val Ser Tyr Arg Val   Asp Lys Tyr 
    13700                 13705                 13710             


Lys His   Met Leu Thr Ile Lys   Asp Cys Gly Phe Pro   Asp Glu Gly 
    13715                 13720                 13725             


Glu Tyr   Ile Val Thr Ala Gly   Gln Asp Lys Ser Val   Ala Glu Leu 
    13730                 13735                 13740             


Leu Ile   Ile Glu Ala Pro Thr   Glu Phe Val Glu His   Leu Glu Asp 
    13745                 13750                 13755             


Gln Thr   Val Thr Glu Phe Asp   Asp Ala Val Phe Ser   Cys Gln Leu 
    13760                 13765                 13770             


Ser Arg   Glu Lys Ala Asn Val   Lys Trp Tyr Arg Asn   Gly Arg Glu 
    13775                 13780                 13785             


Ile Lys   Glu Gly Lys Lys Tyr   Lys Phe Glu Lys Asp   Gly Ser Ile 
    13790                 13795                 13800             


His Arg   Leu Ile Ile Lys Asp   Cys Arg Leu Asp Asp   Glu Cys Glu 
    13805                 13810                 13815             


Tyr Ala   Cys Gly Val Glu Asp   Arg Lys Ser Arg Ala   Arg Leu Phe 
    13820                 13825                 13830             


Val Glu   Glu Ile Pro Val Glu   Ile Ile Arg Pro Pro   Gln Asp Ile 
    13835                 13840                 13845             


Leu Glu   Ala Pro Gly Ala Asp   Val Val Phe Leu Ala   Glu Leu Asn 
    13850                 13855                 13860             


Lys Asp   Lys Val Glu Val Gln   Trp Leu Arg Asn Asn   Met Val Val 
    13865                 13870                 13875             


Val Gln   Gly Asp Lys His Gln   Met Met Ser Glu Gly   Lys Ile His 
    13880                 13885                 13890             


Arg Leu   Gln Ile Cys Asp Ile   Lys Pro Arg Asp Gln   Gly Glu Tyr 
    13895                 13900                 13905             


Arg Phe   Ile Ala Lys Asp Lys   Glu Ala Arg Ala Lys   Leu Glu Leu 
    13910                 13915                 13920             


Ala Ala   Ala Pro Lys Ile Lys   Thr Ala Asp Gln Asp   Leu Val Val 
    13925                 13930                 13935             


Asp Val   Gly Lys Pro Leu Thr   Met Val Val Pro Tyr   Asp Ala Tyr 
    13940                 13945                 13950             


Pro Lys   Ala Glu Ala Glu Trp   Phe Lys Glu Asn Glu   Pro Leu Ser 
    13955                 13960                 13965             


Thr Lys   Thr Ile Asp Thr Thr   Ala Glu Gln Thr Ser   Phe Arg Ile 
    13970                 13975                 13980             


Leu Glu   Ala Lys Lys Gly Asp   Lys Gly Arg Tyr Lys   Ile Val Leu 
    13985                 13990                 13995             


Gln Asn   Lys His Gly Lys Ala   Glu Gly Phe Ile Asn   Leu Lys Val 
    14000                 14005                 14010             


Ile Asp   Val Pro Gly Pro Val   Arg Asn Leu Glu Val   Thr Glu Thr 
    14015                 14020                 14025             


Phe Asp   Gly Glu Val Ser Leu   Ala Trp Glu Glu Pro   Leu Thr Asp 
    14030                 14035                 14040             


Gly Gly   Ser Lys Ile Ile Gly   Tyr Val Val Glu Arg   Arg Asp Ile 
    14045                 14050                 14055             


Lys Arg   Lys Thr Trp Val Leu   Ala Thr Asp Arg Ala   Glu Ser Cys 
    14060                 14065                 14070             


Glu Phe   Thr Val Thr Gly Leu   Gln Lys Gly Gly Val   Glu Tyr Leu 
    14075                 14080                 14085             


Phe Arg   Val Ser Ala Arg Asn   Arg Val Gly Thr Gly   Glu Pro Val 
    14090                 14095                 14100             


Glu Thr   Asp Asn Pro Val Glu   Ala Arg Ser Lys Tyr   Asp Val Pro 
    14105                 14110                 14115             


Gly Pro   Pro Leu Asn Val Thr   Ile Thr Asp Val Asn   Arg Phe Gly 
    14120                 14125                 14130             


Val Ser   Leu Thr Trp Glu Pro   Pro Glu Tyr Asp Gly   Gly Ala Glu 
    14135                 14140                 14145             


Ile Thr   Asn Tyr Val Ile Glu   Leu Arg Asp Lys Thr   Ser Ile Arg 
    14150                 14155                 14160             


Trp Asp   Thr Ala Met Thr Val   Arg Ala Glu Asp Leu   Ser Ala Thr 
    14165                 14170                 14175             


Val Thr   Asp Val Val Glu Gly   Gln Glu Tyr Ser Phe   Arg Val Arg 
    14180                 14185                 14190             


Ala Gln   Asn Arg Ile Gly Val   Gly Lys Pro Ser Ala   Ala Thr Pro 
    14195                 14200                 14205             


Phe Val   Lys Val Ala Asp Pro   Ile Glu Arg Pro Ser   Pro Pro Val 
    14210                 14215                 14220             


Asn Leu   Thr Ser Ser Asp Gln   Thr Gln Ser Ser Val   Gln Leu Lys 
    14225                 14230                 14235             


Trp Glu   Pro Pro Leu Lys Asp   Gly Gly Ser Pro Ile   Leu Gly Tyr 
    14240                 14245                 14250             


Ile Ile   Glu Arg Cys Glu Glu   Gly Lys Asp Asn Trp   Ile Arg Cys 
    14255                 14260                 14265             


Asn Met   Lys Leu Val Pro Glu   Leu Thr Tyr Lys Val   Thr Gly Leu 
    14270                 14275                 14280             


Glu Lys   Gly Asn Lys Tyr Leu   Tyr Arg Val Ser Ala   Glu Asn Lys 
    14285                 14290                 14295             


Ala Gly   Val Ser Asp Pro Ser   Glu Ile Leu Gly Pro   Leu Thr Ala 
    14300                 14305                 14310             


Asp Asp   Ala Phe Val Glu Pro   Thr Met Asp Leu Ser   Ala Phe Lys 
    14315                 14320                 14325             


Asp Gly   Leu Glu Val Ile Val   Pro Asn Pro Ile Thr   Ile Leu Val 
    14330                 14335                 14340             


Pro Ser   Thr Gly Tyr Pro Arg   Pro Thr Ala Thr Trp   Cys Phe Gly 
    14345                 14350                 14355             


Asp Lys   Val Leu Glu Thr Gly   Asp Arg Val Lys Met   Lys Thr Leu 
    14360                 14365                 14370             


Ser Ala   Tyr Ala Glu Leu Val   Ile Ser Pro Ser Glu   Arg Ser Asp 
    14375                 14380                 14385             


Lys Gly   Ile Tyr Thr Leu Lys   Leu Glu Asn Arg Val   Lys Thr Ile 
    14390                 14395                 14400             


Ser Gly   Glu Ile Asp Val Asn   Val Ile Ala Arg Pro   Ser Ala Pro 
    14405                 14410                 14415             


Lys Glu   Leu Lys Phe Gly Asp   Ile Thr Lys Asp Ser   Val His Leu 
    14420                 14425                 14430             


Thr Trp   Glu Pro Pro Asp Asp   Asp Gly Gly Ser Pro   Leu Thr Gly 
    14435                 14440                 14445             


Tyr Val   Val Glu Lys Arg Glu   Val Ser Arg Lys Thr   Trp Thr Lys 
    14450                 14455                 14460             


Val Met   Asp Phe Val Thr Asp   Leu Glu Phe Thr Val   Pro Asp Leu 
    14465                 14470                 14475             


Val Gln   Gly Lys Glu Tyr Leu   Phe Lys Val Cys Ala   Arg Asn Lys 
    14480                 14485                 14490             


Cys Gly   Pro Gly Glu Pro Ala   Tyr Val Asp Glu Pro   Val Asn Met 
    14495                 14500                 14505             


Ser Thr   Pro Ala Thr Val Pro   Asp Pro Pro Glu Asn   Val Lys Trp 
    14510                 14515                 14520             


Arg Asp   Arg Thr Ala Asn Ser   Ile Phe Leu Thr Trp   Asp Pro Pro 
    14525                 14530                 14535             


Lys Asn   Asp Gly Gly Ser Arg   Ile Lys Gly Tyr Ile   Val Glu Arg 
    14540                 14545                 14550             


Cys Pro   Arg Gly Ser Asp Lys   Trp Val Ala Cys Gly   Glu Pro Val 
    14555                 14560                 14565             


Ala Glu   Thr Lys Met Glu Val   Thr Gly Leu Glu Glu   Gly Lys Trp 
    14570                 14575                 14580             


Tyr Ala   Tyr Arg Val Lys Ala   Leu Asn Arg Gln Gly   Ala Ser Lys 
    14585                 14590                 14595             


Pro Ser   Arg Pro Thr Glu Glu   Ile Gln Ala Val Asp   Thr Gln Glu 
    14600                 14605                 14610             


Ala Pro   Glu Ile Phe Leu Asp   Val Lys Leu Leu Ala   Gly Leu Thr 
    14615                 14620                 14625             


Val Lys   Ala Gly Thr Lys Ile   Glu Leu Pro Ala Thr   Val Thr Gly 
    14630                 14635                 14640             


Lys Pro   Glu Pro Lys Ile Thr   Trp Thr Lys Ala Asp   Met Ile Leu 
    14645                 14650                 14655             


Lys Gln   Asp Lys Arg Ile Thr   Ile Glu Asn Val Pro   Lys Lys Ser 
    14660                 14665                 14670             


Thr Val   Thr Ile Val Asp Ser   Lys Arg Ser Asp Thr   Gly Thr Tyr 
    14675                 14680                 14685             


Ile Ile   Glu Ala Val Asn Val   Cys Gly Arg Ala Thr   Ala Val Val 
    14690                 14695                 14700             


Glu Val   Asn Val Leu Asp Lys   Pro Gly Pro Pro Ala   Ala Phe Asp 
    14705                 14710                 14715             


Ile Thr   Asp Val Thr Asn Glu   Ser Cys Leu Leu Thr   Trp Asn Pro 
    14720                 14725                 14730             


Pro Arg   Asp Asp Gly Gly Ser   Lys Ile Thr Asn Tyr   Val Val Glu 
    14735                 14740                 14745             


Arg Arg   Ala Thr Asp Ser Glu   Val Trp His Lys Leu   Ser Ser Thr 
    14750                 14755                 14760             


Val Lys   Asp Thr Asn Phe Lys   Ala Thr Lys Leu Ile   Pro Asn Lys 
    14765                 14770                 14775             


Glu Tyr   Ile Phe Arg Val Ala   Ala Glu Asn Met Tyr   Gly Val Gly 
    14780                 14785                 14790             


Glu Pro   Val Gln Ala Ser Pro   Ile Thr Ala Lys Tyr   Gln Phe Asp 
    14795                 14800                 14805             


Pro Pro   Gly Pro Pro Thr Arg   Leu Glu Pro Ser Asp   Ile Thr Lys 
    14810                 14815                 14820             


Asp Ala   Val Thr Leu Thr Trp   Cys Glu Pro Asp Asp   Asp Gly Gly 
    14825                 14830                 14835             


Ser Pro   Ile Thr Gly Tyr Trp   Val Glu Arg Leu Asp   Pro Asp Thr 
    14840                 14845                 14850             


Asp Lys   Trp Val Arg Cys Asn   Lys Met Pro Val Lys   Asp Thr Thr 
    14855                 14860                 14865             


Tyr Arg   Val Lys Gly Leu Thr   Asn Lys Lys Lys Tyr   Arg Phe Arg 
    14870                 14875                 14880             


Val Leu   Ala Glu Asn Leu Ala   Gly Pro Gly Lys Pro   Ser Lys Ser 
    14885                 14890                 14895             


Thr Glu   Pro Ile Leu Ile Lys   Asp Pro Ile Asp Pro   Pro Trp Pro 
    14900                 14905                 14910             


Pro Gly   Lys Pro Thr Val Lys   Asp Val Gly Lys Thr   Ser Val Arg 
    14915                 14920                 14925             


Leu Asn   Trp Thr Lys Pro Glu   His Asp Gly Gly Ala   Lys Ile Glu 
    14930                 14935                 14940             


Ser Tyr   Val Ile Glu Met Leu   Lys Thr Gly Thr Asp   Glu Trp Val 
    14945                 14950                 14955             


Arg Val   Ala Glu Gly Val Pro   Thr Thr Gln His Leu   Leu Pro Gly 
    14960                 14965                 14970             


Leu Met   Glu Gly Gln Glu Tyr   Ser Phe Arg Val Arg   Ala Val Asn 
    14975                 14980                 14985             


Lys Ala   Gly Glu Ser Glu Pro   Ser Glu Pro Ser Asp   Pro Val Leu 
    14990                 14995                 15000             


Cys Arg   Glu Lys Leu Tyr Pro   Pro Ser Pro Pro Arg   Trp Leu Glu 
    15005                 15010                 15015             


Val Ile   Asn Ile Thr Lys Asn   Thr Ala Asp Leu Lys   Trp Thr Val 
    15020                 15025                 15030             


Pro Glu   Lys Asp Gly Gly Ser   Pro Ile Thr Asn Tyr   Ile Val Glu 
    15035                 15040                 15045             


Lys Arg   Asp Val Arg Arg Lys   Gly Trp Gln Thr Val   Asp Thr Thr 
    15050                 15055                 15060             


Val Lys   Asp Thr Lys Cys Thr   Val Thr Pro Leu Thr   Glu Gly Ser 
    15065                 15070                 15075             


Leu Tyr   Val Phe Arg Val Ala   Ala Glu Asn Ala Ile   Gly Gln Ser 
    15080                 15085                 15090             


Asp Tyr   Thr Glu Ile Glu Asp   Ser Val Leu Ala Lys   Asp Thr Phe 
    15095                 15100                 15105             


Thr Thr   Pro Gly Pro Pro Tyr   Ala Leu Ala Val Val   Asp Val Thr 
    15110                 15115                 15120             


Lys Arg   His Val Asp Leu Lys   Trp Glu Pro Pro Lys   Asn Asp Gly 
    15125                 15130                 15135             


Gly Arg   Pro Ile Gln Arg Tyr   Val Ile Glu Lys Lys   Glu Arg Leu 
    15140                 15145                 15150             


Gly Thr   Arg Trp Val Lys Ala   Gly Lys Thr Ala Gly   Pro Asp Cys 
    15155                 15160                 15165             


Asn Phe   Arg Val Thr Asp Val   Ile Glu Gly Thr Glu   Val Gln Phe 
    15170                 15175                 15180             


Gln Val   Arg Ala Glu Asn Glu   Ala Gly Val Gly His   Pro Ser Glu 
    15185                 15190                 15195             


Pro Thr   Glu Ile Leu Ser Ile   Glu Asp Pro Thr Ser   Pro Pro Ser 
    15200                 15205                 15210             


Pro Pro   Leu Asp Leu His Val   Thr Asp Ala Gly Arg   Lys His Ile 
    15215                 15220                 15225             


Ala Ile   Ala Trp Lys Pro Pro   Glu Lys Asn Gly Gly   Ser Pro Ile 
    15230                 15235                 15240             


Ile Gly   Tyr His Val Glu Met   Cys Pro Val Gly Thr   Glu Lys Trp 
    15245                 15250                 15255             


Met Arg   Val Asn Ser Arg Pro   Ile Lys Asp Leu Lys   Phe Lys Val 
    15260                 15265                 15270             


Glu Glu   Gly Val Val Pro Asp   Lys Glu Tyr Val Leu   Arg Val Arg 
    15275                 15280                 15285             


Ala Val   Asn Ala Ile Gly Val   Ser Glu Pro Ser Glu   Ile Ser Glu 
    15290                 15295                 15300             


Asn Val   Val Ala Lys Asp Pro   Asp Cys Lys Pro Thr   Ile Asp Leu 
    15305                 15310                 15315             


Glu Thr   His Asp Ile Ile Val   Ile Glu Gly Glu Lys   Leu Ser Ile 
    15320                 15325                 15330             


Pro Val   Pro Phe Arg Ala Val   Pro Val Pro Thr Val   Ser Trp His 
    15335                 15340                 15345             


Lys Asp   Gly Lys Glu Val Lys   Ala Ser Asp Arg Leu   Thr Met Lys 
    15350                 15355                 15360             


Asn Asp   His Ile Ser Ala His   Leu Glu Val Pro Lys   Ser Val Arg 
    15365                 15370                 15375             


Ala Asp   Ala Gly Ile Tyr Thr   Ile Thr Leu Glu Asn   Lys Leu Gly 
    15380                 15385                 15390             


Ser Ala   Thr Ala Ser Ile Asn   Val Lys Val Ile Gly   Leu Pro Gly 
    15395                 15400                 15405             


Pro Cys   Lys Asp Ile Lys Ala   Ser Asp Ile Thr Lys   Ser Ser Cys 
    15410                 15415                 15420             


Lys Leu   Thr Trp Glu Pro Pro   Glu Phe Asp Gly Gly   Thr Pro Ile 
    15425                 15430                 15435             


Leu His   Tyr Val Leu Glu Arg   Arg Glu Ala Gly Arg   Arg Thr Tyr 
    15440                 15445                 15450             


Ile Pro   Val Met Ser Gly Glu   Asn Lys Leu Ser Trp   Thr Val Lys 
    15455                 15460                 15465             


Asp Leu   Ile Pro Asn Gly Glu   Tyr Phe Phe Arg Val   Lys Ala Val 
    15470                 15475                 15480             


Asn Lys   Val Gly Gly Gly Glu   Tyr Ile Glu Leu Lys   Asn Pro Val 
    15485                 15490                 15495             


Ile Ala   Gln Asp Pro Lys Gln   Pro Pro Asp Pro Pro   Val Asp Val 
    15500                 15505                 15510             


Glu Val   His Asn Pro Thr Ala   Glu Ala Met Thr Ile   Thr Trp Lys 
    15515                 15520                 15525             


Pro Pro   Leu Tyr Asp Gly Gly   Ser Lys Ile Met Gly   Tyr Ile Ile 
    15530                 15535                 15540             


Glu Lys   Ile Ala Lys Gly Glu   Glu Arg Trp Lys Arg   Cys Asn Glu 
    15545                 15550                 15555             


His Leu   Val Pro Ile Leu Thr   Tyr Thr Ala Lys Gly   Leu Glu Glu 
    15560                 15565                 15570             


Gly Lys   Glu Tyr Gln Phe Arg   Val Arg Ala Glu Asn   Ala Ala Gly 
    15575                 15580                 15585             


Ile Ser   Glu Pro Ser Arg Ala   Thr Pro Pro Thr Lys   Ala Val Asp 
    15590                 15595                 15600             


Pro Ile   Asp Ala Pro Lys Val   Ile Leu Arg Thr Ser   Leu Glu Val 
    15605                 15610                 15615             


Lys Arg   Gly Asp Glu Ile Ala   Leu Asp Ala Ser Ile   Ser Gly Ser 
    15620                 15625                 15630             


Pro Tyr   Pro Thr Ile Thr Trp   Ile Lys Asp Glu Asn   Val Ile Val 
    15635                 15640                 15645             


Pro Glu   Glu Ile Lys Lys Arg   Ala Ala Pro Leu Val   Arg Arg Arg 
    15650                 15655                 15660             


Lys Gly   Glu Val Gln Glu Glu   Glu Pro Phe Val Leu   Pro Leu Thr 
    15665                 15670                 15675             


Gln Arg   Leu Ser Ile Asp Asn   Ser Lys Lys Gly Glu   Ser Gln Leu 
    15680                 15685                 15690             


Arg Val   Arg Asp Ser Leu Arg   Pro Asp His Gly Leu   Tyr Met Ile 
    15695                 15700                 15705             


Lys Val   Glu Asn Asp His Gly   Ile Ala Lys Ala Pro   Cys Thr Val 
    15710                 15715                 15720             


Ser Val   Leu Asp Thr Pro Gly   Pro Pro Ile Asn Phe   Val Phe Glu 
    15725                 15730                 15735             


Asp Ile   Arg Lys Thr Ser Val   Leu Cys Lys Trp Glu   Pro Pro Leu 
    15740                 15745                 15750             


Asp Asp   Gly Gly Ser Glu Ile   Ile Asn Tyr Thr Leu   Glu Lys Lys 
    15755                 15760                 15765             


Asp Lys   Thr Lys Pro Asp Ser   Glu Trp Ile Val Val   Thr Ser Thr 
    15770                 15775                 15780             


Leu Arg   His Cys Lys Tyr Ser   Val Thr Lys Leu Ile   Glu Gly Lys 
    15785                 15790                 15795             


Glu Tyr   Leu Phe Arg Val Arg   Ala Glu Asn Arg Phe   Gly Pro Gly 
    15800                 15805                 15810             


Pro Pro   Cys Val Ser Lys Pro   Leu Val Ala Lys Asp   Pro Phe Gly 
    15815                 15820                 15825             


Pro Pro   Asp Ala Pro Asp Lys   Pro Ile Val Glu Asp   Val Thr Ser 
    15830                 15835                 15840             


Asn Ser   Met Leu Val Lys Trp   Asn Glu Pro Lys Asp   Asn Gly Ser 
    15845                 15850                 15855             


Pro Ile   Leu Gly Tyr Trp Leu   Glu Lys Arg Glu Val   Asn Ser Thr 
    15860                 15865                 15870             


His Trp   Ser Arg Val Asn Lys   Ser Leu Leu Asn Ala   Leu Lys Ala 
    15875                 15880                 15885             


Asn Val   Asp Gly Leu Leu Glu   Gly Leu Thr Tyr Val   Phe Arg Val 
    15890                 15895                 15900             


Cys Ala   Glu Asn Ala Ala Gly   Pro Gly Lys Phe Ser   Pro Pro Ser 
    15905                 15910                 15915             


Asp Pro   Lys Thr Ala His Asp   Pro Ile Ser Pro Pro   Gly Pro Pro 
    15920                 15925                 15930             


Ile Pro   Arg Val Thr Asp Thr   Ser Ser Thr Thr Ile   Glu Leu Glu 
    15935                 15940                 15945             


Trp Glu   Pro Pro Ala Phe Asn   Gly Gly Gly Glu Ile   Val Gly Tyr 
    15950                 15955                 15960             


Phe Val   Asp Lys Gln Leu Val   Gly Thr Asn Glu Trp   Ser Arg Cys 
    15965                 15970                 15975             


Thr Glu   Lys Met Ile Lys Val   Arg Gln Tyr Thr Val   Lys Glu Ile 
    15980                 15985                 15990             


Arg Glu   Gly Ala Asp Tyr Lys   Leu Arg Val Ser Ala   Val Asn Ala 
    15995                 16000                 16005             


Ala Gly   Glu Gly Pro Pro Gly   Glu Thr Gln Pro Val   Thr Val Ala 
    16010                 16015                 16020             


Glu Pro   Gln Glu Pro Pro Ala   Val Glu Leu Asp Val   Ser Val Lys 
    16025                 16030                 16035             


Gly Gly   Ile Gln Ile Met Ala   Gly Lys Thr Leu Arg   Ile Pro Ala 
    16040                 16045                 16050             


Val Val   Thr Gly Arg Pro Val   Pro Thr Lys Val Trp   Thr Lys Glu 
    16055                 16060                 16065             


Glu Gly   Glu Leu Asp Lys Asp   Arg Val Val Ile Asp   Asn Val Gly 
    16070                 16075                 16080             


Thr Lys   Ser Glu Leu Ile Ile   Lys Asp Ala Leu Arg   Lys Asp His 
    16085                 16090                 16095             


Gly Arg   Tyr Val Ile Thr Ala   Thr Asn Ser Cys Gly   Ser Lys Phe 
    16100                 16105                 16110             


Ala Ala   Ala Arg Val Glu Val   Phe Asp Val Pro Gly   Pro Val Leu 
    16115                 16120                 16125             


Asp Leu   Lys Pro Val Val Thr   Asn Arg Lys Met Cys   Leu Leu Asn 
    16130                 16135                 16140             


Trp Ser   Asp Pro Glu Asp Asp   Gly Gly Ser Glu Ile   Thr Gly Phe 
    16145                 16150                 16155             


Ile Ile   Glu Arg Lys Asp Ala   Lys Met His Thr Trp   Arg Gln Pro 
    16160                 16165                 16170             


Ile Glu   Thr Glu Arg Ser Lys   Cys Asp Ile Thr Gly   Leu Leu Glu 
    16175                 16180                 16185             


Gly Gln   Glu Tyr Lys Phe Arg   Val Ile Ala Lys Asn   Lys Phe Gly 
    16190                 16195                 16200             


Cys Gly   Pro Pro Val Glu Ile   Gly Pro Ile Leu Ala   Val Asp Pro 
    16205                 16210                 16215             


Leu Gly   Pro Pro Thr Ser Pro   Glu Arg Leu Thr Tyr   Thr Glu Arg 
    16220                 16225                 16230             


Thr Lys   Ser Thr Ile Thr Leu   Asp Trp Lys Glu Pro   Arg Ser Asn 
    16235                 16240                 16245             


Gly Gly   Ser Pro Ile Gln Gly   Tyr Ile Ile Glu Lys   Arg Arg His 
    16250                 16255                 16260             


Asp Lys   Pro Asp Phe Glu Arg   Val Asn Lys Arg Leu   Cys Pro Thr 
    16265                 16270                 16275             


Thr Ser   Phe Leu Val Glu Asn   Leu Asp Glu His Gln   Met Tyr Glu 
    16280                 16285                 16290             


Phe Arg   Val Lys Ala Val Asn   Glu Ile Gly Glu Ser   Glu Pro Ser 
    16295                 16300                 16305             


Leu Pro   Leu Asn Val Val Ile   Gln Asp Asp Glu Val   Pro Pro Thr 
    16310                 16315                 16320             


Ile Lys   Leu Arg Leu Ser Val   Arg Gly Asp Thr Ile   Lys Val Lys 
    16325                 16330                 16335             


Ala Gly   Glu Pro Val His Ile   Pro Ala Asp Val Thr   Gly Leu Pro 
    16340                 16345                 16350             


Met Pro   Lys Ile Glu Trp Ser   Lys Asn Glu Thr Val   Ile Glu Lys 
    16355                 16360                 16365             


Pro Thr   Asp Ala Leu Gln Ile   Thr Lys Glu Glu Val   Ser Arg Ser 
    16370                 16375                 16380             


Glu Ala   Lys Thr Glu Leu Ser   Ile Pro Lys Ala Val   Arg Glu Asp 
    16385                 16390                 16395             


Lys Gly   Thr Tyr Thr Val Thr   Ala Ser Asn Arg Leu   Gly Ser Val 
    16400                 16405                 16410             


Phe Arg   Asn Val His Val Glu   Val Tyr Asp Arg Pro   Ser Pro Pro 
    16415                 16420                 16425             


Arg Asn   Leu Ala Val Thr Asp   Ile Lys Ala Glu Ser   Cys Tyr Leu 
    16430                 16435                 16440             


Thr Trp   Asp Ala Pro Leu Asp   Asn Gly Gly Ser Glu   Ile Thr His 
    16445                 16450                 16455             


Tyr Val   Ile Asp Lys Arg Asp   Ala Ser Arg Lys Lys   Ala Glu Trp 
    16460                 16465                 16470             


Glu Glu   Val Thr Asn Thr Ala   Val Glu Lys Arg Tyr   Gly Ile Trp 
    16475                 16480                 16485             


Lys Leu   Ile Pro Asn Gly Gln   Tyr Glu Phe Arg Val   Arg Ala Val 
    16490                 16495                 16500             


Asn Lys   Tyr Gly Ile Ser Asp   Glu Cys Lys Ser Asp   Lys Val Val 
    16505                 16510                 16515             


Ile Gln   Asp Pro Tyr Arg Leu   Pro Gly Pro Pro Gly   Lys Pro Lys 
    16520                 16525                 16530             


Val Leu   Ala Arg Thr Lys Gly   Ser Met Leu Val Ser   Trp Thr Pro 
    16535                 16540                 16545             


Pro Leu   Asp Asn Gly Gly Ser   Pro Ile Thr Gly Tyr   Trp Leu Glu 
    16550                 16555                 16560             


Lys Arg   Glu Glu Gly Ser Pro   Tyr Trp Ser Arg Val   Ser Arg Ala 
    16565                 16570                 16575             


Pro Ile   Thr Lys Val Gly Leu   Lys Gly Val Glu Phe   Asn Val Pro 
    16580                 16585                 16590             


Arg Leu   Leu Glu Gly Val Lys   Tyr Gln Phe Arg Ala   Met Ala Ile 
    16595                 16600                 16605             


Asn Ala   Ala Gly Ile Gly Pro   Pro Ser Glu Pro Ser   Asp Pro Glu 
    16610                 16615                 16620             


Val Ala   Gly Asp Pro Ile Phe   Pro Pro Gly Pro Pro   Ser Cys Pro 
    16625                 16630                 16635             


Glu Val   Lys Asp Lys Thr Lys   Ser Ser Ile Ser Leu   Gly Trp Lys 
    16640                 16645                 16650             


Pro Pro   Ala Lys Asp Gly Gly   Ser Pro Ile Lys Gly   Tyr Ile Val 
    16655                 16660                 16665             


Glu Met   Gln Glu Glu Gly Thr   Thr Asp Trp Lys Arg   Val Asn Glu 
    16670                 16675                 16680             


Pro Asp   Lys Leu Ile Thr Thr   Cys Glu Cys Val Val   Pro Asn Leu 
    16685                 16690                 16695             


Lys Glu   Leu Arg Lys Tyr Arg   Phe Arg Val Lys Ala   Val Asn Glu 
    16700                 16705                 16710             


Ala Gly   Glu Ser Glu Pro Ser   Asp Thr Thr Gly Glu   Ile Pro Ala 
    16715                 16720                 16725             


Thr Asp   Ile Gln Glu Glu Pro   Glu Val Phe Ile Asp   Ile Gly Ala 
    16730                 16735                 16740             


Gln Asp   Cys Leu Val Cys Lys   Ala Gly Ser Gln Ile   Arg Ile Pro 
    16745                 16750                 16755             


Ala Val   Ile Lys Gly Arg Pro   Thr Pro Lys Ser Ser   Trp Glu Phe 
    16760                 16765                 16770             


Asp Gly   Lys Ala Lys Lys Ala   Met Lys Asp Gly Val   His Asp Ile 
    16775                 16780                 16785             


Pro Glu   Asp Ala Gln Leu Glu   Thr Ala Glu Asn Ser   Ser Val Ile 
    16790                 16795                 16800             


Ile Ile   Pro Glu Cys Lys Arg   Ser His Thr Gly Lys   Tyr Ser Ile 
    16805                 16810                 16815             


Thr Ala   Lys Asn Lys Ala Gly   Gln Lys Thr Ala Asn   Cys Arg Val 
    16820                 16825                 16830             


Lys Val   Met Asp Val Pro Gly   Pro Pro Lys Asp Leu   Lys Val Ser 
    16835                 16840                 16845             


Asp Ile   Thr Arg Gly Ser Cys   Arg Leu Ser Trp Lys   Met Pro Asp 
    16850                 16855                 16860             


Asp Asp   Gly Gly Asp Arg Ile   Lys Gly Tyr Val Ile   Glu Lys Arg 
    16865                 16870                 16875             


Thr Ile   Asp Gly Lys Ala Trp   Thr Lys Val Asn Pro   Asp Cys Gly 
    16880                 16885                 16890             


Ser Thr   Thr Phe Val Val Pro   Asp Leu Leu Ser Glu   Gln Gln Tyr 
    16895                 16900                 16905             


Phe Phe   Arg Val Arg Ala Glu   Asn Arg Phe Gly Ile   Gly Pro Pro 
    16910                 16915                 16920             


Val Glu   Thr Ile Gln Arg Thr   Thr Ala Arg Asp Pro   Ile Tyr Pro 
    16925                 16930                 16935             


Pro Asp   Pro Pro Ile Lys Leu   Lys Ile Gly Leu Ile   Thr Lys Asn 
    16940                 16945                 16950             


Thr Val   His Leu Ser Trp Lys   Pro Pro Lys Asn Asp   Gly Gly Ser 
    16955                 16960                 16965             


Pro Val   Thr His Tyr Ile Val   Glu Cys Leu Ala Trp   Asp Pro Thr 
    16970                 16975                 16980             


Gly Thr   Lys Lys Glu Ala Trp   Arg Gln Cys Asn Lys   Arg Asp Val 
    16985                 16990                 16995             


Glu Glu   Leu Gln Phe Thr Val   Glu Asp Leu Val Glu   Gly Gly Glu 
    17000                 17005                 17010             


Tyr Glu   Phe Arg Val Lys Ala   Val Asn Ala Ala Gly   Val Ser Lys 
    17015                 17020                 17025             


Pro Ser   Ala Thr Val Gly Pro   Val Thr Val Lys Asp   Gln Thr Cys 
    17030                 17035                 17040             


Pro Pro   Ser Ile Asp Leu Lys   Glu Phe Met Glu Val   Glu Glu Gly 
    17045                 17050                 17055             


Thr Asn   Val Asn Ile Val Ala   Lys Ile Lys Gly Val   Pro Phe Pro 
    17060                 17065                 17070             


Thr Leu   Thr Trp Phe Lys Ala   Pro Pro Lys Lys Pro   Asp Asn Lys 
    17075                 17080                 17085             


Glu Pro   Val Leu Tyr Asp Thr   His Val Asn Lys Leu   Val Val Asp 
    17090                 17095                 17100             


Asp Thr   Cys Thr Leu Val Ile   Pro Gln Ser Arg Arg   Ser Asp Thr 
    17105                 17110                 17115             


Gly Leu   Tyr Thr Ile Thr Ala   Val Asn Asn Leu Gly   Thr Ala Ser 
    17120                 17125                 17130             


Lys Glu   Met Arg Leu Asn Val   Leu Gly Arg Pro Gly   Pro Pro Val 
    17135                 17140                 17145             


Gly Pro   Ile Lys Phe Glu Ser   Val Ser Ala Asp Gln   Met Thr Leu 
    17150                 17155                 17160             


Ser Trp   Phe Pro Pro Lys Asp   Asp Gly Gly Ser Lys   Ile Thr Asn 
    17165                 17170                 17175             


Tyr Val   Ile Glu Lys Arg Glu   Ala Asn Arg Lys Thr   Trp Val His 
    17180                 17185                 17190             


Val Ser   Ser Glu Pro Lys Glu   Cys Thr Tyr Thr Ile   Pro Lys Leu 
    17195                 17200                 17205             


Leu Glu   Gly His Glu Tyr Val   Phe Arg Ile Met Ala   Gln Asn Lys 
    17210                 17215                 17220             


Tyr Gly   Ile Gly Glu Pro Leu   Asp Ser Glu Pro Glu   Thr Ala Arg 
    17225                 17230                 17235             


Asn Leu   Phe Ser Val Pro Gly   Ala Pro Asp Lys Pro   Thr Val Ser 
    17240                 17245                 17250             


Ser Val   Thr Arg Asn Ser Met   Thr Val Asn Trp Glu   Glu Pro Glu 
    17255                 17260                 17265             


Tyr Asp   Gly Gly Ser Pro Val   Thr Gly Tyr Trp Leu   Glu Met Lys 
    17270                 17275                 17280             


Asp Thr   Thr Ser Lys Arg Trp   Lys Arg Val Asn Arg   Asp Pro Ile 
    17285                 17290                 17295             


Lys Ala   Met Thr Leu Gly Val   Ser Tyr Lys Val Thr   Gly Leu Ile 
    17300                 17305                 17310             


Glu Gly   Ser Asp Tyr Gln Phe   Arg Val Tyr Ala Ile   Asn Ala Ala 
    17315                 17320                 17325             


Gly Val   Gly Pro Ala Ser Leu   Pro Ser Asp Pro Ala   Thr Ala Arg 
    17330                 17335                 17340             


Asp Pro   Ile Ala Pro Pro Gly   Pro Pro Phe Pro Lys   Val Thr Asp 
    17345                 17350                 17355             


Trp Thr   Lys Ser Ser Ala Asp   Leu Glu Trp Ser Pro   Pro Leu Lys 
    17360                 17365                 17370             


Asp Gly   Gly Ser Lys Val Thr   Gly Tyr Ile Val Glu   Tyr Lys Glu 
    17375                 17380                 17385             


Glu Gly   Lys Glu Glu Trp Glu   Lys Gly Lys Asp Lys   Glu Val Arg 
    17390                 17395                 17400             


Gly Thr   Lys Leu Val Val Thr   Gly Leu Lys Glu Gly   Ala Phe Tyr 
    17405                 17410                 17415             


Lys Phe   Arg Val Arg Ala Val   Asn Ile Ala Gly Ile   Gly Glu Pro 
    17420                 17425                 17430             


Gly Glu   Val Thr Asp Val Ile   Glu Met Lys Asp Arg   Leu Val Ser 
    17435                 17440                 17445             


Pro Asp   Leu Gln Leu Asp Ala   Ser Val Arg Asp Arg   Ile Val Val 
    17450                 17455                 17460             


His Ala   Gly Gly Val Ile Arg   Ile Ile Ala Tyr Val   Ser Gly Lys 
    17465                 17470                 17475             


Pro Pro   Pro Thr Val Thr Trp   Asn Met Asn Glu Arg   Thr Leu Pro 
    17480                 17485                 17490             


Gln Glu   Ala Thr Ile Glu Thr   Thr Ala Ile Ser Ser   Ser Met Val 
    17495                 17500                 17505             


Ile Lys   Asn Cys Gln Arg Ser   His Gln Gly Val Tyr   Ser Leu Leu 
    17510                 17515                 17520             


Ala Lys   Asn Glu Ala Gly Glu   Arg Lys Lys Thr Ile   Ile Val Asp 
    17525                 17530                 17535             


Val Leu   Asp Val Pro Gly Pro   Val Gly Thr Pro Phe   Leu Ala His 
    17540                 17545                 17550             


Asn Leu   Thr Asn Glu Ser Cys   Lys Leu Thr Trp Phe   Ser Pro Glu 
    17555                 17560                 17565             


Asp Asp   Gly Gly Ser Pro Ile   Thr Asn Tyr Val Ile   Glu Lys Arg 
    17570                 17575                 17580             


Glu Ser   Asp Arg Arg Ala Trp   Thr Pro Val Thr Tyr   Thr Val Thr 
    17585                 17590                 17595             


Arg Gln   Asn Ala Thr Val Gln   Gly Leu Ile Gln Gly   Lys Ala Tyr 
    17600                 17605                 17610             


Phe Phe   Arg Ile Ala Ala Glu   Asn Ser Ile Gly Met   Gly Pro Phe 
    17615                 17620                 17625             


Val Glu   Thr Ser Glu Ala Leu   Val Ile Arg Glu Pro   Ile Thr Val 
    17630                 17635                 17640             


Pro Glu   Arg Pro Glu Asp Leu   Glu Val Lys Glu Val   Thr Lys Asn 
    17645                 17650                 17655             


Thr Val   Thr Leu Thr Trp Asn   Pro Pro Lys Tyr Asp   Gly Gly Ser 
    17660                 17665                 17670             


Glu Ile   Ile Asn Tyr Val Leu   Glu Ser Arg Leu Ile   Gly Thr Glu 
    17675                 17680                 17685             


Lys Phe   His Lys Val Thr Asn   Asp Asn Leu Leu Ser   Arg Lys Tyr 
    17690                 17695                 17700             


Thr Val   Lys Gly Leu Lys Glu   Gly Asp Thr Tyr Glu   Tyr Arg Val 
    17705                 17710                 17715             


Ser Ala   Val Asn Ile Val Gly   Gln Gly Lys Pro Ser   Phe Cys Thr 
    17720                 17725                 17730             


Lys Pro   Ile Thr Cys Lys Asp   Glu Leu Ala Pro Pro   Thr Leu His 
    17735                 17740                 17745             


Leu Asp   Phe Arg Asp Lys Leu   Thr Ile Arg Val Gly   Glu Ala Phe 
    17750                 17755                 17760             


Ala Leu   Thr Gly Arg Tyr Ser   Gly Lys Pro Lys Pro   Lys Val Ser 
    17765                 17770                 17775             


Trp Phe   Lys Asp Glu Ala Asp   Val Leu Glu Asp Asp   Arg Thr His 
    17780                 17785                 17790             


Ile Lys   Thr Thr Pro Ala Thr   Leu Ala Leu Glu Lys   Ile Lys Ala 
    17795                 17800                 17805             


Lys Arg   Ser Asp Ser Gly Lys   Tyr Cys Val Val Val   Glu Asn Ser 
    17810                 17815                 17820             


Thr Gly   Ser Arg Lys Gly Phe   Cys Gln Val Asn Val   Val Asp Arg 
    17825                 17830                 17835             


Pro Gly   Pro Pro Val Gly Pro   Val Ser Phe Asp Glu   Val Thr Lys 
    17840                 17845                 17850             


Asp Tyr   Met Val Ile Ser Trp   Lys Pro Pro Leu Asp   Asp Gly Gly 
    17855                 17860                 17865             


Ser Lys   Ile Thr Asn Tyr Ile   Ile Glu Lys Lys Glu   Val Gly Lys 
    17870                 17875                 17880             


Asp Val   Trp Met Pro Val Thr   Ser Ala Ser Ala Lys   Thr Thr Cys 
    17885                 17890                 17895             


Lys Val   Ser Lys Leu Leu Glu   Gly Lys Asp Tyr Ile   Phe Arg Ile 
    17900                 17905                 17910             


His Ala   Glu Asn Leu Tyr Gly   Ile Ser Asp Pro Leu   Val Ser Asp 
    17915                 17920                 17925             


Ser Met   Lys Ala Lys Asp Arg   Phe Arg Val Pro Asp   Ala Pro Asp 
    17930                 17935                 17940             


Gln Pro   Ile Val Thr Glu Val   Thr Lys Asp Ser Ala   Leu Val Thr 
    17945                 17950                 17955             


Trp Asn   Lys Pro His Asp Gly   Gly Lys Pro Ile Thr   Asn Tyr Ile 
    17960                 17965                 17970             


Leu Glu   Lys Arg Glu Thr Met   Ser Lys Arg Trp Ala   Arg Val Thr 
    17975                 17980                 17985             


Lys Asp   Pro Ile His Pro Tyr   Thr Lys Phe Arg Val   Pro Asp Leu 
    17990                 17995                 18000             


Leu Glu   Gly Cys Gln Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Glu 
    18005                 18010                 18015             


Ile Gly   Ile Gly Asp Pro Ser   Pro Pro Ser Lys Pro   Val Phe Ala 
    18020                 18025                 18030             


Lys Asp   Pro Ile Ala Lys Pro   Ser Pro Pro Val Asn   Pro Glu Ala 
    18035                 18040                 18045             


Ile Asp   Thr Thr Cys Asn Ser   Val Asp Leu Thr Trp   Gln Pro Pro 
    18050                 18055                 18060             


Arg His   Asp Gly Gly Ser Lys   Ile Leu Gly Tyr Ile   Val Glu Tyr 
    18065                 18070                 18075             


Gln Lys   Val Gly Asp Glu Glu   Trp Arg Arg Ala Asn   His Thr Pro 
    18080                 18085                 18090             


Glu Ser   Cys Pro Glu Thr Lys   Tyr Lys Val Thr Gly   Leu Arg Asp 
    18095                 18100                 18105             


Gly Gln   Thr Tyr Lys Phe Arg   Val Leu Ala Val Asn   Ala Ala Gly 
    18110                 18115                 18120             


Glu Ser   Asp Pro Ala His Val   Pro Glu Pro Val Leu   Val Lys Asp 
    18125                 18130                 18135             


Arg Leu   Glu Pro Pro Glu Leu   Ile Leu Asp Ala Asn   Met Ala Arg 
    18140                 18145                 18150             


Glu Gln   His Ile Lys Val Gly   Asp Thr Leu Arg Leu   Ser Ala Ile 
    18155                 18160                 18165             


Ile Lys   Gly Val Pro Phe Pro   Lys Val Thr Trp Lys   Lys Glu Asp 
    18170                 18175                 18180             


Arg Asp   Ala Pro Thr Lys Ala   Arg Ile Asp Val Thr   Pro Val Gly 
    18185                 18190                 18195             


Ser Lys   Leu Glu Ile Arg Asn   Ala Ala His Glu Asp   Gly Gly Ile 
    18200                 18205                 18210             


Tyr Ser   Leu Thr Val Glu Asn   Pro Ala Gly Ser Lys   Thr Val Ser 
    18215                 18220                 18225             


Val Lys   Val Leu Val Leu Asp   Lys Pro Gly Pro Pro   Arg Asp Leu 
    18230                 18235                 18240             


Glu Val   Ser Glu Ile Arg Lys   Asp Ser Cys Tyr Leu   Thr Trp Lys 
    18245                 18250                 18255             


Glu Pro   Leu Asp Asp Gly Gly   Ser Val Ile Thr Asn   Tyr Val Val 
    18260                 18265                 18270             


Glu Arg   Arg Asp Val Ala Ser   Ala Gln Trp Ser Pro   Leu Ser Ala 
    18275                 18280                 18285             


Thr Ser   Lys Lys Lys Ser His   Phe Ala Lys His Leu   Asn Glu Gly 
    18290                 18295                 18300             


Asn Gln   Tyr Leu Phe Arg Val   Ala Ala Glu Asn Gln   Tyr Gly Arg 
    18305                 18310                 18315             


Gly Pro   Phe Val Glu Thr Pro   Lys Pro Ile Lys Ala   Leu Asp Pro 
    18320                 18325                 18330             


Leu His   Pro Pro Gly Pro Pro   Lys Asp Leu His His   Val Asp Val 
    18335                 18340                 18345             


Asp Lys   Thr Glu Val Ser Leu   Val Trp Asn Lys Pro   Asp Arg Asp 
    18350                 18355                 18360             


Gly Gly   Ser Pro Ile Thr Gly   Tyr Leu Val Glu Tyr   Gln Glu Glu 
    18365                 18370                 18375             


Gly Thr   Gln Asp Trp Ile Lys   Phe Lys Thr Val Thr   Asn Leu Glu 
    18380                 18385                 18390             


Cys Val   Val Thr Gly Leu Gln   Gln Gly Lys Thr Tyr   Arg Phe Arg 
    18395                 18400                 18405             


Val Lys   Ala Glu Asn Ile Val   Gly Leu Gly Leu Pro   Asp Thr Thr 
    18410                 18415                 18420             


Ile Pro   Ile Glu Cys Gln Glu   Lys Leu Val Pro Pro   Ser Val Glu 
    18425                 18430                 18435             


Leu Asp   Val Lys Leu Ile Glu   Gly Leu Val Val Lys   Ala Gly Thr 
    18440                 18445                 18450             


Thr Val   Arg Phe Pro Ala Ile   Ile Arg Gly Val Pro   Val Pro Thr 
    18455                 18460                 18465             


Ala Lys   Trp Thr Thr Asp Gly   Ser Glu Ile Lys Thr   Asp Glu His 
    18470                 18475                 18480             


Tyr Thr   Val Glu Thr Asp Asn   Phe Ser Ser Val Leu   Thr Ile Lys 
    18485                 18490                 18495             


Asn Cys   Leu Arg Arg Asp Thr   Gly Glu Tyr Gln Ile   Thr Val Ser 
    18500                 18505                 18510             


Asn Ala   Ala Gly Ser Lys Thr   Val Ala Val His Leu   Thr Val Leu 
    18515                 18520                 18525             


Asp Val   Pro Gly Pro Pro Thr   Gly Pro Ile Asn Ile   Leu Asp Val 
    18530                 18535                 18540             


Thr Pro   Glu His Met Thr Ile   Ser Trp Gln Pro Pro   Lys Asp Asp 
    18545                 18550                 18555             


Gly Gly   Ser Pro Val Ile Asn   Tyr Ile Val Glu Lys   Gln Asp Thr 
    18560                 18565                 18570             


Arg Lys   Asp Thr Trp Gly Val   Val Ser Ser Gly Ser   Ser Lys Thr 
    18575                 18580                 18585             


Lys Leu   Lys Ile Pro His Leu   Gln Lys Gly Cys Glu   Tyr Val Phe 
    18590                 18595                 18600             


Arg Val   Arg Ala Glu Asn Lys   Ile Gly Val Gly Pro   Pro Leu Asp 
    18605                 18610                 18615             


Ser Thr   Pro Thr Val Ala Lys   His Lys Phe Ser Pro   Pro Ser Pro 
    18620                 18625                 18630             


Pro Gly   Lys Pro Val Val Thr   Asp Ile Thr Glu Asn   Ala Ala Thr 
    18635                 18640                 18645             


Val Ser   Trp Thr Leu Pro Lys   Ser Asp Gly Gly Ser   Pro Ile Thr 
    18650                 18655                 18660             


Gly Tyr   Tyr Met Glu Arg Arg   Glu Val Thr Gly Lys   Trp Val Arg 
    18665                 18670                 18675             


Val Asn   Lys Thr Pro Ile Ala   Asp Leu Lys Phe Arg   Val Thr Gly 
    18680                 18685                 18690             


Leu Tyr   Glu Gly Asn Thr Tyr   Glu Phe Arg Val Phe   Ala Glu Asn 
    18695                 18700                 18705             


Leu Ala   Gly Leu Ser Lys Pro   Ser Pro Ser Ser Asp   Pro Ile Lys 
    18710                 18715                 18720             


Ala Cys   Arg Pro Ile Lys Pro   Pro Gly Pro Pro Ile   Asn Pro Lys 
    18725                 18730                 18735             


Leu Lys   Asp Lys Ser Arg Glu   Thr Ala Asp Leu Val   Trp Thr Lys 
    18740                 18745                 18750             


Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu Gly Tyr   Val Val Glu 
    18755                 18760                 18765             


Cys Gln   Lys Pro Gly Thr Ala   Gln Trp Asn Arg Ile   Asn Lys Asp 
    18770                 18775                 18780             


Glu Leu   Ile Arg Gln Cys Ala   Phe Arg Val Pro Gly   Leu Ile Glu 
    18785                 18790                 18795             


Gly Asn   Glu Tyr Arg Phe Arg   Ile Lys Ala Ala Asn   Ile Val Gly 
    18800                 18805                 18810             


Glu Gly   Glu Pro Arg Glu Leu   Ala Glu Ser Val Ile   Ala Lys Asp 
    18815                 18820                 18825             


Ile Leu   His Pro Pro Glu Val   Glu Leu Asp Val Thr   Cys Arg Asp 
    18830                 18835                 18840             


Val Ile   Thr Val Arg Val Gly   Gln Thr Ile Arg Ile   Leu Ala Arg 
    18845                 18850                 18855             


Val Lys   Gly Arg Pro Glu Pro   Asp Ile Thr Trp Thr   Lys Glu Gly 
    18860                 18865                 18870             


Lys Val   Leu Val Arg Glu Lys   Arg Val Asp Leu Ile   Gln Asp Leu 
    18875                 18880                 18885             


Pro Arg   Val Glu Leu Gln Ile   Lys Glu Ala Val Arg   Ala Asp His 
    18890                 18895                 18900             


Gly Lys   Tyr Ile Ile Ser Ala   Lys Asn Ser Ser Gly   His Ala Gln 
    18905                 18910                 18915             


Gly Ser   Ala Ile Val Asn Val   Leu Asp Arg Pro Gly   Pro Cys Gln 
    18920                 18925                 18930             


Asn Leu   Lys Val Thr Asn Val   Thr Lys Glu Asn Cys   Thr Ile Ser 
    18935                 18940                 18945             


Trp Glu   Asn Pro Leu Asp Asn   Gly Gly Ser Glu Ile   Thr Asn Phe 
    18950                 18955                 18960             


Ile Val   Glu Tyr Arg Lys Pro   Asn Gln Lys Gly Trp   Ser Ile Val 
    18965                 18970                 18975             


Ala Ser   Asp Val Thr Lys Arg   Leu Ile Lys Ala Asn   Leu Leu Ala 
    18980                 18985                 18990             


Asn Asn   Glu Tyr Tyr Phe Arg   Val Cys Ala Glu Asn   Lys Val Gly 
    18995                 19000                 19005             


Val Gly   Pro Thr Ile Glu Thr   Lys Thr Pro Ile Leu   Ala Ile Asn 
    19010                 19015                 19020             


Pro Ile   Asp Arg Pro Gly Glu   Pro Glu Asn Leu His   Ile Ala Asp 
    19025                 19030                 19035             


Lys Gly   Lys Thr Phe Val Tyr   Leu Lys Trp Arg Arg   Pro Asp Tyr 
    19040                 19045                 19050             


Asp Gly   Gly Ser Pro Asn Leu   Ser Tyr His Val Glu   Arg Arg Leu 
    19055                 19060                 19065             


Lys Gly   Ser Asp Asp Trp Glu   Arg Val His Lys Gly   Ser Ile Lys 
    19070                 19075                 19080             


Glu Thr   His Tyr Met Val Asp   Arg Cys Val Glu Asn   Gln Ile Tyr 
    19085                 19090                 19095             


Glu Phe   Arg Val Gln Thr Lys   Asn Glu Gly Gly Glu   Ser Asp Trp 
    19100                 19105                 19110             


Val Lys   Thr Glu Glu Val Val   Val Lys Glu Asp Leu   Gln Lys Pro 
    19115                 19120                 19125             


Val Leu   Asp Leu Lys Leu Ser   Gly Val Leu Thr Val   Lys Ala Gly 
    19130                 19135                 19140             


Asp Thr   Ile Arg Leu Glu Ala   Gly Val Arg Gly Lys   Pro Phe Pro 
    19145                 19150                 19155             


Glu Val   Ala Trp Thr Lys Asp   Lys Asp Ala Thr Asp   Leu Thr Arg 
    19160                 19165                 19170             


Ser Pro   Arg Val Lys Ile Asp   Thr Arg Ala Asp Ser   Ser Lys Phe 
    19175                 19180                 19185             


Ser Leu   Thr Lys Ala Lys Arg   Ser Asp Gly Gly Lys   Tyr Val Val 
    19190                 19195                 19200             


Thr Ala   Thr Asn Thr Ala Gly   Ser Phe Val Ala Tyr   Ala Thr Val 
    19205                 19210                 19215             


Asn Val   Leu Asp Lys Pro Gly   Pro Val Arg Asn Leu   Lys Ile Val 
    19220                 19225                 19230             


Asp Val   Ser Ser Asp Arg Cys   Thr Val Cys Trp Asp   Pro Pro Glu 
    19235                 19240                 19245             


Asp Asp   Gly Gly Cys Glu Ile   Gln Asn Tyr Ile Leu   Glu Lys Cys 
    19250                 19255                 19260             


Glu Thr   Lys Arg Met Val Trp   Ser Thr Tyr Ser Ala   Thr Val Leu 
    19265                 19270                 19275             


Thr Pro   Gly Thr Thr Val Thr   Arg Leu Ile Glu Gly   Asn Glu Tyr 
    19280                 19285                 19290             


Ile Phe   Arg Val Arg Ala Glu   Asn Lys Ile Gly Thr   Gly Pro Pro 
    19295                 19300                 19305             


Thr Glu   Ser Lys Pro Val Ile   Ala Lys Thr Lys Tyr   Asp Lys Pro 
    19310                 19315                 19320             


Gly Arg   Pro Asp Pro Pro Glu   Val Thr Lys Val Ser   Lys Glu Glu 
    19325                 19330                 19335             


Met Thr   Val Val Trp Asn Pro   Pro Glu Tyr Asp Gly   Gly Lys Ser 
    19340                 19345                 19350             


Ile Thr   Gly Tyr Phe Leu Glu   Lys Lys Glu Lys His   Ser Thr Arg 
    19355                 19360                 19365             


Trp Val   Pro Val Asn Lys Ser   Ala Ile Pro Glu Arg   Arg Met Lys 
    19370                 19375                 19380             


Val Gln   Asn Leu Leu Pro Asp   His Glu Tyr Gln Phe   Arg Val Lys 
    19385                 19390                 19395             


Ala Glu   Asn Glu Ile Gly Ile   Gly Glu Pro Ser Leu   Pro Ser Arg 
    19400                 19405                 19410             


Pro Val   Val Ala Lys Asp Pro   Ile Glu Pro Pro Gly   Pro Pro Thr 
    19415                 19420                 19425             


Asn Phe   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Thr Leu Gly 
    19430                 19435                 19440             


Trp Gly   Lys Pro Val Tyr Asp   Gly Gly Ala Pro Ile   Ile Gly Tyr 
    19445                 19450                 19455             


Val Val   Glu Met Arg Pro Lys   Ile Ala Asp Ala Ser   Pro Asp Glu 
    19460                 19465                 19470             


Gly Trp   Lys Arg Cys Asn Ala   Ala Ala Gln Leu Val   Arg Lys Glu 
    19475                 19480                 19485             


Phe Thr   Val Thr Ser Leu Asp   Glu Asn Gln Glu Tyr   Glu Phe Arg 
    19490                 19495                 19500             


Val Cys   Ala Gln Asn Gln Val   Gly Ile Gly Arg Pro   Ala Glu Leu 
    19505                 19510                 19515             


Lys Glu   Ala Ile Lys Pro Lys   Glu Ile Leu Glu Pro   Pro Glu Ile 
    19520                 19525                 19530             


Asp Leu   Asp Ala Ser Met Arg   Lys Leu Val Ile Val   Arg Ala Gly 
    19535                 19540                 19545             


Cys Pro   Ile Arg Leu Phe Ala   Ile Val Arg Gly Arg   Pro Ala Pro 
    19550                 19555                 19560             


Lys Val   Thr Trp Arg Lys Val   Gly Ile Asp Asn Val   Val Arg Lys 
    19565                 19570                 19575             


Gly Gln   Val Asp Leu Val Asp   Thr Met Ala Phe Leu   Val Ile Pro 
    19580                 19585                 19590             


Asn Ser   Thr Arg Asp Asp Ser   Gly Lys Tyr Ser Leu   Thr Leu Val 
    19595                 19600                 19605             


Asn Pro   Ala Gly Glu Lys Ala   Val Phe Val Asn Val   Arg Val Leu 
    19610                 19615                 19620             


Asp Thr   Pro Gly Pro Val Ser   Asp Leu Lys Val Ser   Asp Val Thr 
    19625                 19630                 19635             


Lys Thr   Ser Cys His Val Ser   Trp Ala Pro Pro Glu   Asn Asp Gly 
    19640                 19645                 19650             


Gly Ser   Gln Val Thr His Tyr   Ile Val Glu Lys Arg   Glu Ala Asp 
    19655                 19660                 19665             


Arg Lys   Thr Trp Ser Thr Val   Thr Pro Glu Val Lys   Lys Thr Ser 
    19670                 19675                 19680             


Phe His   Val Thr Asn Leu Val   Pro Gly Asn Glu Tyr   Tyr Phe Arg 
    19685                 19690                 19695             


Val Thr   Ala Val Asn Glu Tyr   Gly Pro Gly Val Pro   Thr Asp Val 
    19700                 19705                 19710             


Pro Lys   Pro Val Leu Ala Ser   Asp Pro Leu Ser Glu   Pro Asp Pro 
    19715                 19720                 19725             


Pro Arg   Lys Leu Glu Val Thr   Glu Met Thr Lys Asn   Ser Ala Thr 
    19730                 19735                 19740             


Leu Ala   Trp Leu Pro Pro Leu   Arg Asp Gly Gly Ala   Lys Ile Asp 
    19745                 19750                 19755             


Gly Tyr   Ile Thr Ser Tyr Arg   Glu Glu Glu Gln Pro   Ala Asp Arg 
    19760                 19765                 19770             


Trp Thr   Glu Tyr Ser Val Val   Lys Asp Leu Ser Leu   Val Val Thr 
    19775                 19780                 19785             


Gly Leu   Lys Glu Gly Lys Lys   Tyr Lys Phe Arg Val   Ala Ala Arg 
    19790                 19795                 19800             


Asn Ala   Val Gly Val Ser Leu   Pro Arg Glu Ala Glu   Gly Val Tyr 
    19805                 19810                 19815             


Glu Ala   Lys Glu Gln Leu Leu   Pro Pro Lys Ile Leu   Met Pro Glu 
    19820                 19825                 19830             


Gln Ile   Thr Ile Lys Ala Gly   Lys Lys Leu Arg Ile   Glu Ala His 
    19835                 19840                 19845             


Val Tyr   Gly Lys Pro His Pro   Thr Cys Lys Trp Lys   Lys Gly Glu 
    19850                 19855                 19860             


Asp Glu   Val Val Thr Ser Ser   His Leu Ala Val His   Lys Ala Asp 
    19865                 19870                 19875             


Ser Ser   Ser Ile Leu Ile Ile   Lys Asp Val Thr Arg   Lys Asp Ser 
    19880                 19885                 19890             


Gly Tyr   Tyr Ser Leu Thr Ala   Glu Asn Ser Ser Gly   Thr Asp Thr 
    19895                 19900                 19905             


Gln Lys   Ile Lys Val Val Val   Met Asp Ala Pro Gly   Pro Pro Gln 
    19910                 19915                 19920             


Pro Pro   Phe Asp Ile Ser Asp   Ile Asp Ala Asp Ala   Cys Ser Leu 
    19925                 19930                 19935             


Ser Trp   His Ile Pro Leu Glu   Asp Gly Gly Ser Asn   Ile Thr Asn 
    19940                 19945                 19950             


Tyr Ile   Val Glu Lys Cys Asp   Val Ser Arg Gly Asp   Trp Val Thr 
    19955                 19960                 19965             


Ala Leu   Ala Ser Val Thr Lys   Thr Ser Cys Arg Val   Gly Lys Leu 
    19970                 19975                 19980             


Ile Pro   Gly Gln Glu Tyr Ile   Phe Arg Val Arg Ala   Glu Asn Arg 
    19985                 19990                 19995             


Phe Gly   Ile Ser Glu Pro Leu   Thr Ser Pro Lys Met   Val Ala Gln 
    20000                 20005                 20010             


Phe Pro   Phe Gly Val Pro Ser   Glu Pro Lys Asn Ala   Arg Val Thr 
    20015                 20020                 20025             


Lys Val   Asn Lys Asp Cys Ile   Phe Val Ala Trp Asp   Arg Pro Asp 
    20030                 20035                 20040             


Ser Asp   Gly Gly Ser Pro Ile   Ile Gly Tyr Leu Ile   Glu Arg Lys 
    20045                 20050                 20055             


Glu Arg   Asn Ser Leu Leu Trp   Val Lys Ala Asn Asp   Thr Leu Val 
    20060                 20065                 20070             


Arg Ser   Thr Glu Tyr Pro Cys   Ala Gly Leu Val Glu   Gly Leu Glu 
    20075                 20080                 20085             


Tyr Ser   Phe Arg Ile Tyr Ala   Leu Asn Lys Ala Gly   Ser Ser Pro 
    20090                 20095                 20100             


Pro Ser   Lys Pro Thr Glu Tyr   Val Thr Ala Arg Met   Pro Val Asp 
    20105                 20110                 20115             


Pro Pro   Gly Lys Pro Glu Val   Ile Asp Val Thr Lys   Ser Thr Val 
    20120                 20125                 20130             


Ser Leu   Ile Trp Ala Arg Pro   Lys His Asp Gly Gly   Ser Lys Ile 
    20135                 20140                 20145             


Ile Gly   Tyr Phe Val Glu Ala   Cys Lys Leu Pro Gly   Asp Lys Trp 
    20150                 20155                 20160             


Val Arg   Cys Asn Thr Ala Pro   His Gln Ile Pro Gln   Glu Glu Tyr 
    20165                 20170                 20175             


Thr Ala   Thr Gly Leu Glu Glu   Lys Ala Gln Tyr Gln   Phe Arg Ala 
    20180                 20185                 20190             


Ile Ala   Arg Thr Ala Val Asn   Ile Ser Pro Pro Ser   Glu Pro Ser 
    20195                 20200                 20205             


Asp Pro   Val Thr Ile Leu Ala   Glu Asn Val Pro Pro   Arg Ile Asp 
    20210                 20215                 20220             


Leu Ser   Val Ala Met Lys Ser   Leu Leu Thr Val Lys   Ala Gly Thr 
    20225                 20230                 20235             


Asn Val   Cys Leu Asp Ala Thr   Val Phe Gly Lys Pro   Met Pro Thr 
    20240                 20245                 20250             


Val Ser   Trp Lys Lys Asp Gly   Thr Leu Leu Lys Pro   Ala Glu Gly 
    20255                 20260                 20265             


Ile Lys   Met Ala Met Gln Arg   Asn Leu Cys Thr Leu   Glu Leu Phe 
    20270                 20275                 20280             


Ser Val   Asn Arg Lys Asp Ser   Gly Asp Tyr Thr Ile   Thr Ala Glu 
    20285                 20290                 20295             


Asn Ser   Ser Gly Ser Lys Ser   Ala Thr Ile Lys Leu   Lys Val Leu 
    20300                 20305                 20310             


Asp Lys   Pro Gly Pro Pro Ala   Ser Val Lys Ile Asn   Lys Met Tyr 
    20315                 20320                 20325             


Ser Asp   Arg Ala Met Leu Ser   Trp Glu Pro Pro Leu   Glu Asp Gly 
    20330                 20335                 20340             


Gly Ser   Glu Ile Thr Asn Tyr   Ile Val Asp Lys Arg   Glu Thr Ser 
    20345                 20350                 20355             


Arg Pro   Asn Trp Ala Gln Val   Ser Ala Thr Val Pro   Ile Thr Ser 
    20360                 20365                 20370             


Cys Ser   Val Glu Lys Leu Ile   Glu Gly His Glu Tyr   Gln Phe Arg 
    20375                 20380                 20385             


Ile Cys   Ala Glu Asn Lys Tyr   Gly Val Gly Asp Pro   Val Phe Thr 
    20390                 20395                 20400             


Glu Pro   Ala Ile Ala Lys Asn   Pro Tyr Asp Pro Pro   Gly Arg Cys 
    20405                 20410                 20415             


Asp Pro   Pro Val Ile Ser Asn   Ile Thr Lys Asp His   Met Thr Val 
    20420                 20425                 20430             


Ser Trp   Lys Pro Pro Ala Asp   Asp Gly Gly Ser Pro   Ile Thr Gly 
    20435                 20440                 20445             


Tyr Leu   Leu Glu Lys Arg Glu   Thr Gln Ala Val Asn   Trp Thr Lys 
    20450                 20455                 20460             


Val Asn   Arg Lys Pro Ile Ile   Glu Arg Thr Leu Lys   Ala Thr Gly 
    20465                 20470                 20475             


Leu Gln   Glu Gly Thr Glu Tyr   Glu Phe Arg Val Thr   Ala Ile Asn 
    20480                 20485                 20490             


Lys Ala   Gly Pro Gly Lys Pro   Ser Asp Ala Ser Lys   Ala Ala Tyr 
    20495                 20500                 20505             


Ala Arg   Asp Pro Gln Tyr Pro   Pro Gly Pro Pro Ala   Phe Pro Lys 
    20510                 20515                 20520             


Val Tyr   Asp Thr Thr Arg Ser   Ser Val Ser Leu Ser   Trp Gly Lys 
    20525                 20530                 20535             


Pro Ala   Tyr Asp Gly Gly Ser   Pro Ile Ile Gly Tyr   Leu Val Glu 
    20540                 20545                 20550             


Val Lys   Arg Ala Asp Ser Asp   Asn Trp Val Arg Cys   Asn Leu Pro 
    20555                 20560                 20565             


Gln Asn   Leu Gln Lys Thr Arg   Phe Glu Val Thr Gly   Leu Met Glu 
    20570                 20575                 20580             


Asp Thr   Gln Tyr Gln Phe Arg   Val Tyr Ala Val Asn   Lys Ile Gly 
    20585                 20590                 20595             


Tyr Ser   Asp Pro Ser Asp Val   Pro Asp Lys His Tyr   Pro Lys Asp 
    20600                 20605                 20610             


Ile Leu   Ile Pro Pro Glu Gly   Glu Leu Asp Ala Asp   Leu Arg Lys 
    20615                 20620                 20625             


Thr Leu   Ile Leu Arg Ala Gly   Val Thr Met Arg Leu   Tyr Val Pro 
    20630                 20635                 20640             


Val Lys   Gly Arg Pro Pro Pro   Lys Ile Thr Trp Ser   Lys Pro Asn 
    20645                 20650                 20655             


Val Asn   Leu Arg Asp Arg Ile   Gly Leu Asp Ile Lys   Ser Thr Asp 
    20660                 20665                 20670             


Phe Asp   Thr Phe Leu Arg Cys   Glu Asn Val Asn Lys   Tyr Asp Ala 
    20675                 20680                 20685             


Gly Lys   Tyr Ile Leu Thr Leu   Glu Asn Ser Cys Gly   Lys Lys Glu 
    20690                 20695                 20700             


Tyr Thr   Ile Val Val Lys Val   Leu Asp Thr Pro Gly   Pro Pro Val 
    20705                 20710                 20715             


Asn Val   Thr Val Lys Glu Ile   Ser Lys Asp Ser Ala   Tyr Val Thr 
    20720                 20725                 20730             


Trp Glu   Pro Pro Ile Ile Asp   Gly Gly Ser Pro Ile   Ile Asn Tyr 
    20735                 20740                 20745             


Val Val   Gln Lys Arg Asp Ala   Glu Arg Lys Ser Trp   Ser Thr Val 
    20750                 20755                 20760             


Thr Thr   Glu Cys Ser Lys Thr   Ser Phe Arg Val Ala   Asn Leu Glu 
    20765                 20770                 20775             


Glu Gly   Lys Ser Tyr Phe Phe   Arg Val Phe Ala Glu   Asn Glu Tyr 
    20780                 20785                 20790             


Gly Ile   Gly Asp Pro Gly Glu   Thr Arg Asp Ala Val   Lys Ala Ser 
    20795                 20800                 20805             


Gln Thr   Pro Gly Pro Val Val   Asp Leu Lys Val Arg   Ser Val Ser 
    20810                 20815                 20820             


Lys Ser   Ser Cys Ser Ile Gly   Trp Lys Lys Pro His   Ser Asp Gly 
    20825                 20830                 20835             


Gly Ser   Arg Ile Ile Gly Tyr   Val Val Asp Phe Leu   Thr Glu Glu 
    20840                 20845                 20850             


Asn Lys   Trp Gln Arg Val Met   Lys Ser Leu Ser Leu   Gln Tyr Ser 
    20855                 20860                 20865             


Ala Lys   Asp Leu Thr Glu Gly   Lys Glu Tyr Thr Phe   Arg Val Ser 
    20870                 20875                 20880             


Ala Glu   Asn Glu Asn Gly Glu   Gly Thr Pro Ser Glu   Ile Thr Val 
    20885                 20890                 20895             


Val Ala   Arg Asp Asp Val Val   Ala Pro Asp Leu Asp   Leu Lys Gly 
    20900                 20905                 20910             


Leu Pro   Asp Leu Cys Tyr Leu   Ala Lys Glu Asn Ser   Asn Phe Arg 
    20915                 20920                 20925             


Leu Lys   Ile Pro Ile Lys Gly   Lys Pro Ala Pro Ser   Val Ser Trp 
    20930                 20935                 20940             


Lys Lys   Gly Glu Asp Pro Leu   Ala Thr Asp Thr Arg   Val Ser Val 
    20945                 20950                 20955             


Glu Ser   Ser Ala Val Asn Thr   Thr Leu Ile Val Tyr   Asp Cys Gln 
    20960                 20965                 20970             


Lys Ser   Asp Ala Gly Lys Tyr   Thr Ile Thr Leu Lys   Asn Val Ala 
    20975                 20980                 20985             


Gly Thr   Lys Glu Gly Thr Ile   Ser Ile Lys Val Val   Gly Lys Pro 
    20990                 20995                 21000             


Gly Ile   Pro Thr Gly Pro Ile   Lys Phe Asp Glu Val   Thr Ala Glu 
    21005                 21010                 21015             


Ala Met   Thr Leu Lys Trp Ala   Pro Pro Lys Asp Asp   Gly Gly Ser 
    21020                 21025                 21030             


Glu Ile   Thr Asn Tyr Ile Leu   Glu Lys Arg Asp Ser   Val Asn Asn 
    21035                 21040                 21045             


Lys Trp   Val Thr Cys Ala Ser   Ala Val Gln Lys Thr   Thr Phe Arg 
    21050                 21055                 21060             


Val Thr   Arg Leu His Glu Gly   Met Glu Tyr Thr Phe   Arg Val Ser 
    21065                 21070                 21075             


Ala Glu   Asn Lys Tyr Gly Val   Gly Glu Gly Leu Lys   Ser Glu Pro 
    21080                 21085                 21090             


Ile Val   Ala Arg His Pro Phe   Asp Val Pro Asp Ala   Pro Pro Pro 
    21095                 21100                 21105             


Pro Asn   Ile Val Asp Val Arg   His Asp Ser Val Ser   Leu Thr Trp 
    21110                 21115                 21120             


Thr Asp   Pro Lys Lys Thr Gly   Gly Ser Pro Ile Thr   Gly Tyr His 
    21125                 21130                 21135             


Leu Glu   Phe Lys Glu Arg Asn   Ser Leu Leu Trp Lys   Arg Ala Asn 
    21140                 21145                 21150             


Lys Thr   Pro Ile Arg Met Arg   Asp Phe Lys Val Thr   Gly Leu Thr 
    21155                 21160                 21165             


Glu Gly   Leu Glu Tyr Glu Phe   Arg Val Met Ala Ile   Asn Leu Ala 
    21170                 21175                 21180             


Gly Val   Gly Lys Pro Ser Leu   Pro Ser Glu Pro Val   Val Ala Leu 
    21185                 21190                 21195             


Asp Pro   Ile Asp Pro Pro Gly   Lys Pro Glu Val Ile   Asn Ile Thr 
    21200                 21205                 21210             


Arg Asn   Ser Val Thr Leu Ile   Trp Thr Glu Pro Lys   Tyr Asp Gly 
    21215                 21220                 21225             


Gly His   Lys Leu Thr Gly Tyr   Ile Val Glu Lys Arg   Asp Leu Pro 
    21230                 21235                 21240             


Ser Lys   Ser Trp Met Lys Ala   Asn His Val Asn Val   Pro Glu Cys 
    21245                 21250                 21255             


Ala Phe   Thr Val Thr Asp Leu   Val Glu Gly Gly Lys   Tyr Glu Phe 
    21260                 21265                 21270             


Arg Ile   Arg Ala Lys Asn Thr   Ala Gly Ala Ile Ser   Ala Pro Ser 
    21275                 21280                 21285             


Glu Ser   Thr Glu Thr Ile Ile   Cys Lys Asp Glu Tyr   Glu Ala Pro 
    21290                 21295                 21300             


Thr Ile   Val Leu Asp Pro Thr   Ile Lys Asp Gly Leu   Thr Ile Lys 
    21305                 21310                 21315             


Ala Gly   Asp Thr Ile Val Leu   Asn Ala Ile Ser Ile   Leu Gly Lys 
    21320                 21325                 21330             


Pro Leu   Pro Lys Ser Ser Trp   Ser Lys Ala Gly Lys   Asp Ile Arg 
    21335                 21340                 21345             


Pro Ser   Asp Ile Thr Gln Ile   Thr Ser Thr Pro Thr   Ser Ser Met 
    21350                 21355                 21360             


Leu Thr   Ile Lys Tyr Ala Thr   Arg Lys Asp Ala Gly   Glu Tyr Thr 
    21365                 21370                 21375             


Ile Thr   Ala Thr Asn Pro Phe   Gly Thr Lys Val Glu   His Val Lys 
    21380                 21385                 21390             


Val Thr   Val Leu Asp Val Pro   Gly Pro Pro Gly Pro   Val Glu Ile 
    21395                 21400                 21405             


Ser Asn   Val Ser Ala Glu Lys   Ala Thr Leu Thr Trp   Thr Pro Pro 
    21410                 21415                 21420             


Leu Glu   Asp Gly Gly Ser Pro   Ile Lys Ser Tyr Ile   Leu Glu Lys 
    21425                 21430                 21435             


Arg Glu   Thr Ser Arg Leu Leu   Trp Thr Val Val Ser   Glu Asp Ile 
    21440                 21445                 21450             


Gln Ser   Cys Arg His Val Ala   Thr Lys Leu Ile Gln   Gly Asn Glu 
    21455                 21460                 21465             


Tyr Ile   Phe Arg Val Ser Ala   Val Asn His Tyr Gly   Lys Gly Glu 
    21470                 21475                 21480             


Pro Val   Gln Ser Glu Pro Val   Lys Met Val Asp Arg   Phe Gly Pro 
    21485                 21490                 21495             


Pro Gly   Pro Pro Glu Lys Pro   Glu Val Ser Asn Val   Thr Lys Asn 
    21500                 21505                 21510             


Thr Ala   Thr Val Ser Trp Lys   Arg Pro Val Asp Asp   Gly Gly Ser 
    21515                 21520                 21525             


Glu Ile   Thr Gly Tyr His Val   Glu Arg Arg Glu Lys   Lys Ser Leu 
    21530                 21535                 21540             


Arg Trp   Val Arg Ala Ile Lys   Thr Pro Val Ser Asp   Leu Arg Cys 
    21545                 21550                 21555             


Lys Val   Thr Gly Leu Gln Glu   Gly Ser Thr Tyr Glu   Phe Arg Val 
    21560                 21565                 21570             


Ser Ala   Glu Asn Arg Ala Gly   Ile Gly Pro Pro Ser   Glu Ala Ser 
    21575                 21580                 21585             


Asp Ser   Val Leu Met Lys Asp   Ala Ala Tyr Pro Pro   Gly Pro Pro 
    21590                 21595                 21600             


Ser Asn   Pro His Val Thr Asp   Thr Thr Lys Lys Ser   Ala Ser Leu 
    21605                 21610                 21615             


Ala Trp   Gly Lys Pro His Tyr   Asp Gly Gly Leu Glu   Ile Thr Gly 
    21620                 21625                 21630             


Tyr Val   Val Glu His Gln Lys   Val Gly Asp Glu Ala   Trp Ile Lys 
    21635                 21640                 21645             


Asp Thr   Thr Gly Thr Ala Leu   Arg Ile Thr Gln Phe   Val Val Pro 
    21650                 21655                 21660             


Asp Leu   Gln Thr Lys Glu Lys   Tyr Asn Phe Arg Ile   Ser Ala Ile 
    21665                 21670                 21675             


Asn Asp   Ala Gly Val Gly Glu   Pro Ala Val Ile Pro   Asp Val Glu 
    21680                 21685                 21690             


Ile Val   Glu Arg Glu Met Ala   Pro Asp Phe Glu Leu   Asp Ala Glu 
    21695                 21700                 21705             


Leu Arg   Arg Thr Leu Val Val   Arg Ala Gly Leu Ser   Ile Arg Ile 
    21710                 21715                 21720             


Phe Val   Pro Ile Lys Gly Arg   Pro Ala Pro Glu Val   Thr Trp Thr 
    21725                 21730                 21735             


Lys Asp   Asn Ile Asn Leu Lys   Asn Arg Ala Asn Ile   Glu Asn Thr 
    21740                 21745                 21750             


Glu Ser   Phe Thr Leu Leu Ile   Ile Pro Glu Cys Asn   Arg Tyr Asp 
    21755                 21760                 21765             


Thr Gly   Lys Phe Val Met Thr   Ile Glu Asn Pro Ala   Gly Lys Lys 
    21770                 21775                 21780             


Ser Gly   Phe Val Asn Val Arg   Val Leu Asp Thr Pro   Gly Pro Val 
    21785                 21790                 21795             


Leu Asn   Leu Arg Pro Thr Asp   Ile Thr Lys Asp Ser   Val Thr Leu 
    21800                 21805                 21810             


His Trp   Asp Leu Pro Leu Ile   Asp Gly Gly Ser Arg   Ile Thr Asn 
    21815                 21820                 21825             


Tyr Ile   Val Glu Lys Arg Glu   Ala Thr Arg Lys Ser   Tyr Ser Thr 
    21830                 21835                 21840             


Ala Thr   Thr Lys Cys His Lys   Cys Thr Tyr Lys Val   Thr Gly Leu 
    21845                 21850                 21855             


Ser Glu   Gly Cys Glu Tyr Phe   Phe Arg Val Met Ala   Glu Asn Glu 
    21860                 21865                 21870             


Tyr Gly   Ile Gly Glu Pro Thr   Glu Thr Thr Glu Pro   Val Lys Ala 
    21875                 21880                 21885             


Ser Glu   Ala Pro Ser Pro Pro   Asp Ser Leu Asn Ile   Met Asp Ile 
    21890                 21895                 21900             


Thr Lys   Ser Thr Val Ser Leu   Ala Trp Pro Lys Pro   Lys His Asp 
    21905                 21910                 21915             


Gly Gly   Ser Lys Ile Thr Gly   Tyr Val Ile Glu Ala   Gln Arg Lys 
    21920                 21925                 21930             


Gly Ser   Asp Gln Trp Thr His   Ile Thr Thr Val Lys   Gly Leu Glu 
    21935                 21940                 21945             


Cys Val   Val Arg Asn Leu Thr   Glu Gly Glu Glu Tyr   Thr Phe Gln 
    21950                 21955                 21960             


Val Met   Ala Val Asn Ser Ala   Gly Arg Ser Ala Pro   Arg Glu Ser 
    21965                 21970                 21975             


Arg Pro   Val Ile Val Lys Glu   Gln Thr Met Leu Pro   Glu Leu Asp 
    21980                 21985                 21990             


Leu Arg   Gly Ile Tyr Gln Lys   Leu Val Ile Ala Lys   Ala Gly Asp 
    21995                 22000                 22005             


Asn Ile   Lys Val Glu Ile Pro   Val Leu Gly Arg Pro   Lys Pro Thr 
    22010                 22015                 22020             


Val Thr   Trp Lys Lys Gly Asp   Gln Ile Leu Lys Gln   Thr Gln Arg 
    22025                 22030                 22035             


Val Asn   Phe Glu Thr Thr Ala   Thr Ser Thr Ile Leu   Asn Ile Asn 
    22040                 22045                 22050             


Glu Cys   Val Arg Ser Asp Ser   Gly Pro Tyr Pro Leu   Thr Ala Arg 
    22055                 22060                 22065             


Asn Ile   Val Gly Glu Val Gly   Asp Val Ile Thr Ile   Gln Val His 
    22070                 22075                 22080             


Asp Ile   Pro Gly Pro Pro Thr   Gly Pro Ile Lys Phe   Asp Glu Val 
    22085                 22090                 22095             


Ser Ser   Asp Phe Val Thr Phe   Ser Trp Asp Pro Pro   Glu Asn Asp 
    22100                 22105                 22110             


Gly Gly   Val Pro Ile Ser Asn   Tyr Val Val Glu Met   Arg Gln Thr 
    22115                 22120                 22125             


Asp Ser   Thr Thr Trp Val Glu   Leu Ala Thr Thr Val   Ile Arg Thr 
    22130                 22135                 22140             


Thr Tyr   Lys Ala Thr Arg Leu   Thr Thr Gly Leu Glu   Tyr Gln Phe 
    22145                 22150                 22155             


Arg Val   Lys Ala Gln Asn Arg   Tyr Gly Val Gly Pro   Gly Ile Thr 
    22160                 22165                 22170             


Ser Ala   Cys Ile Val Ala Asn   Tyr Pro Phe Lys Val   Pro Gly Pro 
    22175                 22180                 22185             


Pro Gly   Thr Pro Gln Val Thr   Ala Val Thr Lys Asp   Ser Met Thr 
    22190                 22195                 22200             


Ile Ser   Trp His Glu Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu 
    22205                 22210                 22215             


Gly Tyr   His Val Glu Arg Lys   Glu Arg Asn Gly Ile   Leu Trp Gln 
    22220                 22225                 22230             


Thr Val   Ser Lys Ala Leu Val   Pro Gly Asn Ile Phe   Lys Ser Ser 
    22235                 22240                 22245             


Gly Leu   Thr Asp Gly Ile Ala   Tyr Glu Phe Arg Val   Ile Ala Glu 
    22250                 22255                 22260             


Asn Met   Ala Gly Lys Ser Lys   Pro Ser Lys Pro Ser   Glu Pro Met 
    22265                 22270                 22275             


Leu Ala   Leu Asp Pro Ile Asp   Pro Pro Gly Lys Pro   Val Pro Leu 
    22280                 22285                 22290             


Asn Ile   Thr Arg His Thr Val   Thr Leu Lys Trp Ala   Lys Pro Glu 
    22295                 22300                 22305             


Tyr Thr   Gly Gly Phe Lys Ile   Thr Ser Tyr Ile Val   Glu Lys Arg 
    22310                 22315                 22320             


Asp Leu   Pro Asn Gly Arg Trp   Leu Lys Ala Asn Phe   Ser Asn Ile 
    22325                 22330                 22335             


Leu Glu   Asn Glu Phe Thr Val   Ser Gly Leu Thr Glu   Asp Ala Ala 
    22340                 22345                 22350             


Tyr Glu   Phe Arg Val Ile Ala   Lys Asn Ala Ala Gly   Ala Ile Ser 
    22355                 22360                 22365             


Pro Pro   Ser Glu Pro Ser Asp   Ala Ile Thr Cys Arg   Asp Asp Val 
    22370                 22375                 22380             


Glu Ala   Pro Lys Ile Lys Val   Asp Val Lys Phe Lys   Asp Thr Val 
    22385                 22390                 22395             


Ile Leu   Lys Ala Gly Glu Ala   Phe Arg Leu Glu Ala   Asp Val Ser 
    22400                 22405                 22410             


Gly Arg   Pro Pro Pro Thr Met   Glu Trp Ser Lys Asp   Gly Lys Glu 
    22415                 22420                 22425             


Leu Glu   Gly Thr Ala Lys Leu   Glu Ile Lys Ile Ala   Asp Phe Ser 
    22430                 22435                 22440             


Thr Asn   Leu Val Asn Lys Asp   Ser Thr Arg Arg Asp   Ser Gly Ala 
    22445                 22450                 22455             


Tyr Thr   Leu Thr Ala Thr Asn   Pro Gly Gly Phe Ala   Lys His Ile 
    22460                 22465                 22470             


Phe Asn   Val Lys Val Leu Asp   Arg Pro Gly Pro Pro   Glu Gly Pro 
    22475                 22480                 22485             


Leu Ala   Val Thr Glu Val Thr   Ser Glu Lys Cys Val   Leu Ser Trp 
    22490                 22495                 22500             


Phe Pro   Pro Leu Asp Asp Gly   Gly Ala Lys Ile Asp   His Tyr Ile 
    22505                 22510                 22515             


Val Gln   Lys Arg Glu Thr Ser   Arg Leu Ala Trp Thr   Asn Val Ala 
    22520                 22525                 22530             


Ser Glu   Val Gln Val Thr Lys   Leu Lys Val Thr Lys   Leu Leu Lys 
    22535                 22540                 22545             


Gly Asn   Glu Tyr Ile Phe Arg   Val Met Ala Val Asn   Lys Tyr Gly 
    22550                 22555                 22560             


Val Gly   Glu Pro Leu Glu Ser   Glu Pro Val Leu Ala   Val Asn Pro 
    22565                 22570                 22575             


Tyr Gly   Pro Pro Asp Pro Pro   Lys Asn Pro Glu Val   Thr Thr Ile 
    22580                 22585                 22590             


Thr Lys   Asp Ser Met Val Val   Cys Trp Gly His Pro   Asp Ser Asp 
    22595                 22600                 22605             


Gly Gly   Ser Glu Ile Ile Asn   Tyr Ile Val Glu Arg   Arg Asp Lys 
    22610                 22615                 22620             


Ala Gly   Gln Arg Trp Ile Lys   Cys Asn Lys Lys Thr   Leu Thr Asp 
    22625                 22630                 22635             


Leu Arg   Tyr Lys Val Ser Gly   Leu Thr Glu Gly His   Glu Tyr Glu 
    22640                 22645                 22650             


Phe Arg   Ile Met Ala Glu Asn   Ala Ala Gly Ile Ser   Ala Pro Ser 
    22655                 22660                 22665             


Pro Thr   Ser Pro Phe Tyr Lys   Ala Cys Asp Thr Val   Phe Lys Pro 
    22670                 22675                 22680             


Gly Pro   Pro Gly Asn Pro Arg   Val Leu Asp Thr Ser   Arg Ser Ser 
    22685                 22690                 22695             


Ile Ser   Ile Ala Trp Asn Lys   Pro Ile Tyr Asp Gly   Gly Ser Glu 
    22700                 22705                 22710             


Ile Thr   Gly Tyr Met Val Glu   Ile Ala Leu Pro Glu   Glu Asp Glu 
    22715                 22720                 22725             


Trp Gln   Ile Val Thr Pro Pro   Ala Gly Leu Lys Ala   Thr Ser Tyr 
    22730                 22735                 22740             


Thr Ile   Thr Gly Leu Thr Glu   Asn Gln Glu Tyr Lys   Ile Arg Ile 
    22745                 22750                 22755             


Tyr Ala   Met Asn Ser Glu Gly   Leu Gly Glu Pro Ala   Leu Val Pro 
    22760                 22765                 22770             


Gly Thr   Pro Lys Ala Glu Asp   Arg Met Leu Pro Pro   Glu Ile Glu 
    22775                 22780                 22785             


Leu Asp   Ala Asp Leu Arg Lys   Val Val Thr Ile Arg   Ala Cys Cys 
    22790                 22795                 22800             


Thr Leu   Arg Leu Phe Val Pro   Ile Lys Gly Arg Pro   Ala Pro Glu 
    22805                 22810                 22815             


Val Lys   Trp Ala Arg Asp His   Gly Glu Ser Leu Asp   Lys Ala Ser 
    22820                 22825                 22830             


Ile Glu   Ser Thr Ser Ser Tyr   Thr Leu Leu Ile Val   Gly Asn Val 
    22835                 22840                 22845             


Asn Arg   Phe Asp Ser Gly Lys   Tyr Ile Leu Thr Val   Glu Asn Ser 
    22850                 22855                 22860             


Ser Gly   Ser Lys Ser Ala Phe   Val Asn Val Arg Val   Leu Asp Thr 
    22865                 22870                 22875             


Pro Gly   Pro Pro Gln Asp Leu   Lys Val Lys Glu Val   Thr Lys Thr 
    22880                 22885                 22890             


Ser Val   Thr Leu Thr Trp Asp   Pro Pro Leu Leu Asp   Gly Gly Ser 
    22895                 22900                 22905             


Lys Ile   Lys Asn Tyr Ile Val   Glu Lys Arg Glu Ser   Thr Arg Lys 
    22910                 22915                 22920             


Ala Tyr   Ser Thr Val Ala Thr   Asn Cys His Lys Thr   Ser Trp Lys 
    22925                 22930                 22935             


Val Asp   Gln Leu Gln Glu Gly   Cys Ser Tyr Tyr Phe   Arg Val Leu 
    22940                 22945                 22950             


Ala Glu   Asn Glu Tyr Gly Ile   Gly Leu Pro Ala Glu   Thr Ala Glu 
    22955                 22960                 22965             


Ser Val   Lys Ala Ser Glu Arg   Pro Leu Pro Pro Gly   Lys Ile Thr 
    22970                 22975                 22980             


Leu Met   Asp Val Thr Arg Asn   Ser Val Ser Leu Ser   Trp Glu Lys 
    22985                 22990                 22995             


Pro Glu   His Asp Gly Gly Ser   Arg Ile Leu Gly Tyr   Ile Val Glu 
    23000                 23005                 23010             


Met Gln   Thr Lys Gly Ser Asp   Lys Trp Ala Thr Cys   Ala Thr Val 
    23015                 23020                 23025             


Lys Val   Thr Glu Ala Thr Ile   Thr Gly Leu Ile Gln   Gly Glu Glu 
    23030                 23035                 23040             


Tyr Ser   Phe Arg Val Ser Ala   Gln Asn Glu Lys Gly   Ile Ser Asp 
    23045                 23050                 23055             


Pro Arg   Gln Leu Ser Val Pro   Val Ile Ala Lys Asp   Leu Val Ile 
    23060                 23065                 23070             


Pro Pro   Ala Phe Lys Leu Leu   Phe Asn Thr Phe Thr   Val Leu Ala 
    23075                 23080                 23085             


Gly Glu   Asp Leu Lys Val Asp   Val Pro Phe Ile Gly   Arg Pro Thr 
    23090                 23095                 23100             


Pro Ala   Val Thr Trp His Lys   Asp Asn Val Pro Leu   Lys Gln Thr 
    23105                 23110                 23115             


Thr Arg   Val Asn Ala Glu Ser   Thr Glu Asn Asn Ser   Leu Leu Thr 
    23120                 23125                 23130             


Ile Lys   Asp Ala Cys Arg Glu   Asp Val Gly His Tyr   Val Val Lys 
    23135                 23140                 23145             


Leu Thr   Asn Ser Ala Gly Glu   Ala Ile Glu Thr Leu   Asn Val Ile 
    23150                 23155                 23160             


Val Leu   Asp Lys Pro Gly Pro   Pro Thr Gly Pro Val   Lys Met Asp 
    23165                 23170                 23175             


Glu Val   Thr Ala Asp Ser Ile   Thr Leu Ser Trp Gly   Pro Pro Lys 
    23180                 23185                 23190             


Tyr Asp   Gly Gly Ser Ser Ile   Asn Asn Tyr Ile Val   Glu Lys Arg 
    23195                 23200                 23205             


Asp Thr   Ser Thr Thr Thr Trp   Gln Ile Val Ser Ala   Thr Val Ala 
    23210                 23215                 23220             


Arg Thr   Thr Ile Lys Ala Cys   Arg Leu Lys Thr Gly   Cys Glu Tyr 
    23225                 23230                 23235             


Gln Phe   Arg Ile Ala Ala Glu   Asn Arg Tyr Gly Lys   Ser Thr Tyr 
    23240                 23245                 23250             


Leu Asn   Ser Glu Pro Thr Val   Ala Gln Tyr Pro Phe   Lys Val Pro 
    23255                 23260                 23265             


Gly Pro   Pro Gly Thr Pro Val   Val Thr Leu Ser Ser   Arg Asp Ser 
    23270                 23275                 23280             


Met Glu   Val Gln Trp Asn Glu   Pro Ile Ser Asp Gly   Gly Ser Arg 
    23285                 23290                 23295             


Val Ile   Gly Tyr His Leu Glu   Arg Lys Glu Arg Asn   Ser Ile Leu 
    23300                 23305                 23310             


Trp Val   Lys Leu Asn Lys Thr   Pro Ile Pro Gln Thr   Lys Phe Lys 
    23315                 23320                 23325             


Thr Thr   Gly Leu Glu Glu Gly   Val Glu Tyr Glu Phe   Arg Val Ser 
    23330                 23335                 23340             


Ala Glu   Asn Ile Val Gly Ile   Gly Lys Pro Ser Lys   Val Ser Glu 
    23345                 23350                 23355             


Cys Tyr   Val Ala Arg Asp Pro   Cys Asp Pro Pro Gly   Arg Pro Glu 
    23360                 23365                 23370             


Ala Ile   Ile Val Thr Arg Asn   Ser Val Thr Leu Gln   Trp Lys Lys 
    23375                 23380                 23385             


Pro Thr   Tyr Asp Gly Gly Ser   Lys Ile Thr Gly Tyr   Ile Val Glu 
    23390                 23395                 23400             


Lys Lys   Glu Leu Pro Glu Gly   Arg Trp Met Lys Ala   Ser Phe Thr 
    23405                 23410                 23415             


Asn Ile   Ile Asp Thr His Phe   Glu Val Thr Gly Leu   Val Glu Asp 
    23420                 23425                 23430             


His Arg   Tyr Glu Phe Arg Val   Ile Ala Arg Asn Ala   Ala Gly Val 
    23435                 23440                 23445             


Phe Ser   Glu Pro Ser Glu Ser   Thr Gly Ala Ile Thr   Ala Arg Asp 
    23450                 23455                 23460             


Glu Val   Asp Pro Pro Arg Ile   Ser Met Asp Pro Lys   Tyr Lys Asp 
    23465                 23470                 23475             


Thr Ile   Val Val His Ala Gly   Glu Ser Phe Lys Val   Asp Ala Asp 
    23480                 23485                 23490             


Ile Tyr   Gly Lys Pro Ile Pro   Thr Ile Gln Trp Ile   Lys Gly Asp 
    23495                 23500                 23505             


Gln Glu   Leu Ser Asn Thr Ala   Arg Leu Glu Ile Lys   Ser Thr Asp 
    23510                 23515                 23520             


Phe Ala   Thr Ser Leu Ser Val   Lys Asp Ala Val Arg   Val Asp Ser 
    23525                 23530                 23535             


Gly Asn   Tyr Ile Leu Lys Ala   Lys Asn Val Ala Gly   Glu Arg Ser 
    23540                 23545                 23550             


Val Thr   Val Asn Val Lys Val   Leu Asp Arg Pro Gly   Pro Pro Glu 
    23555                 23560                 23565             


Gly Pro   Val Val Ile Ser Gly   Val Thr Ala Glu Lys   Cys Thr Leu 
    23570                 23575                 23580             


Ala Trp   Lys Pro Pro Leu Gln   Asp Gly Gly Ser Asp   Ile Ile Asn 
    23585                 23590                 23595             


Tyr Ile   Val Glu Arg Arg Glu   Thr Ser Arg Leu Val   Trp Thr Val 
    23600                 23605                 23610             


Val Asp   Ala Asn Val Gln Thr   Leu Ser Cys Lys Val   Thr Lys Leu 
    23615                 23620                 23625             


Leu Glu   Gly Asn Glu Tyr Thr   Phe Arg Ile Met Ala   Val Asn Lys 
    23630                 23635                 23640             


Tyr Gly   Val Gly Glu Pro Leu   Glu Ser Glu Pro Val   Val Ala Lys 
    23645                 23650                 23655             


Asn Pro   Phe Val Val Pro Asp   Ala Pro Lys Ala Pro   Glu Val Thr 
    23660                 23665                 23670             


Thr Val   Thr Lys Asp Ser Met   Ile Val Val Trp Glu   Arg Pro Ala 
    23675                 23680                 23685             


Ser Asp   Gly Gly Ser Glu Ile   Leu Gly Tyr Val Leu   Glu Lys Arg 
    23690                 23695                 23700             


Asp Lys   Glu Gly Ile Arg Trp   Thr Arg Cys His Lys   Arg Leu Ile 
    23705                 23710                 23715             


Gly Glu   Leu Arg Leu Arg Val   Thr Gly Leu Ile Glu   Asn His Asp 
    23720                 23725                 23730             


Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Ala Ala Gly   Leu Ser Glu 
    23735                 23740                 23745             


Pro Ser   Pro Pro Ser Ala Tyr   Gln Lys Ala Cys Asp   Pro Ile Tyr 
    23750                 23755                 23760             


Lys Pro   Gly Pro Pro Asn Asn   Pro Lys Val Ile Asp   Ile Thr Arg 
    23765                 23770                 23775             


Ser Ser   Val Phe Leu Ser Trp   Ser Lys Pro Ile Tyr   Asp Gly Gly 
    23780                 23785                 23790             


Cys Glu   Ile Gln Gly Tyr Ile   Val Glu Lys Cys Asp   Val Ser Val 
    23795                 23800                 23805             


Gly Glu   Trp Thr Met Cys Thr   Pro Pro Thr Gly Ile   Asn Lys Thr 
    23810                 23815                 23820             


Asn Ile   Glu Val Glu Lys Leu   Leu Glu Lys His Glu   Tyr Asn Phe 
    23825                 23830                 23835             


Arg Ile   Cys Ala Ile Asn Lys   Ala Gly Val Gly Glu   His Ala Asp 
    23840                 23845                 23850             


Val Pro   Gly Pro Ile Ile Val   Glu Glu Lys Leu Glu   Ala Pro Asp 
    23855                 23860                 23865             


Ile Asp   Leu Asp Leu Glu Leu   Arg Lys Ile Ile Asn   Ile Arg Ala 
    23870                 23875                 23880             


Gly Gly   Ser Leu Arg Leu Phe   Val Pro Ile Lys Gly   Arg Pro Thr 
    23885                 23890                 23895             


Pro Glu   Val Lys Trp Gly Lys   Val Asp Gly Glu Ile   Arg Asp Ala 
    23900                 23905                 23910             


Ala Ile   Ile Asp Val Thr Ser   Ser Phe Thr Ser Leu   Val Leu Asp 
    23915                 23920                 23925             


Asn Val   Asn Arg Tyr Asp Ser   Gly Lys Tyr Thr Leu   Thr Leu Glu 
    23930                 23935                 23940             


Asn Ser   Ser Gly Thr Lys Ser   Ala Phe Val Thr Val   Arg Val Leu 
    23945                 23950                 23955             


Asp Thr   Pro Ser Pro Pro Val   Asn Leu Lys Val Thr   Glu Ile Thr 
    23960                 23965                 23970             


Lys Asp   Ser Val Ser Ile Thr   Trp Glu Pro Pro Leu   Leu Asp Gly 
    23975                 23980                 23985             


Gly Ser   Lys Ile Lys Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Thr 
    23990                 23995                 24000             


Arg Lys   Ser Tyr Ala Ala Val   Val Thr Asn Cys His   Lys Asn Ser 
    24005                 24010                 24015             


Trp Lys   Ile Asp Gln Leu Gln   Glu Gly Cys Ser Tyr   Tyr Phe Arg 
    24020                 24025                 24030             


Val Thr   Ala Glu Asn Glu Tyr   Gly Ile Gly Leu Pro   Ala Gln Thr 
    24035                 24040                 24045             


Ala Asp   Pro Ile Lys Val Ala   Glu Val Pro Gln Pro   Pro Gly Lys 
    24050                 24055                 24060             


Ile Thr   Val Asp Asp Val Thr   Arg Asn Ser Val Ser   Leu Ser Trp 
    24065                 24070                 24075             


Thr Lys   Pro Glu His Asp Gly   Gly Ser Lys Ile Ile   Gln Tyr Ile 
    24080                 24085                 24090             


Val Glu   Met Gln Ala Lys His   Ser Glu Lys Trp Ser   Glu Cys Ala 
    24095                 24100                 24105             


Arg Val   Lys Ser Leu Gln Ala   Val Ile Thr Asn Leu   Thr Gln Gly 
    24110                 24115                 24120             


Glu Glu   Tyr Leu Phe Arg Val   Val Ala Val Asn Glu   Lys Gly Arg 
    24125                 24130                 24135             


Ser Asp   Pro Arg Ser Leu Ala   Val Pro Ile Val Ala   Lys Asp Leu 
    24140                 24145                 24150             


Val Ile   Glu Pro Asp Val Lys   Pro Ala Phe Ser Ser   Tyr Ser Val 
    24155                 24160                 24165             


Gln Val   Gly Gln Asp Leu Lys   Ile Glu Val Pro Ile   Ser Gly Arg 
    24170                 24175                 24180             


Pro Lys   Pro Thr Ile Thr Trp   Thr Lys Asp Gly Leu   Pro Leu Lys 
    24185                 24190                 24195             


Gln Thr   Thr Arg Ile Asn Val   Thr Asp Ser Leu Asp   Leu Thr Thr 
    24200                 24205                 24210             


Leu Ser   Ile Lys Glu Thr His   Lys Asp Asp Gly Gly   Gln Tyr Gly 
    24215                 24220                 24225             


Ile Thr   Val Ala Asn Val Val   Gly Gln Lys Thr Ala   Ser Ile Glu 
    24230                 24235                 24240             


Ile Val   Thr Leu Asp Lys Pro   Asp Pro Pro Lys Gly   Pro Val Lys 
    24245                 24250                 24255             


Phe Asp   Asp Val Ser Ala Glu   Ser Ile Thr Leu Ser   Trp Asn Pro 
    24260                 24265                 24270             


Pro Leu   Tyr Thr Gly Gly Cys   Gln Ile Thr Asn Tyr   Ile Val Gln 
    24275                 24280                 24285             


Lys Arg   Asp Thr Thr Thr Thr   Val Trp Asp Val Val   Ser Ala Thr 
    24290                 24295                 24300             


Val Ala   Arg Thr Thr Leu Lys   Val Thr Lys Leu Lys   Thr Gly Thr 
    24305                 24310                 24315             


Glu Tyr   Gln Phe Arg Ile Phe   Ala Glu Asn Arg Tyr   Gly Gln Ser 
    24320                 24325                 24330             


Phe Ala   Leu Glu Ser Asp Pro   Ile Val Ala Gln Tyr   Pro Tyr Lys 
    24335                 24340                 24345             


Glu Pro   Gly Pro Pro Gly Thr   Pro Phe Ala Thr Ala   Ile Ser Lys 
    24350                 24355                 24360             


Asp Ser   Met Val Ile Gln Trp   His Glu Pro Val Asn   Asn Gly Gly 
    24365                 24370                 24375             


Ser Pro   Val Ile Gly Tyr His   Leu Glu Arg Lys Glu   Arg Asn Ser 
    24380                 24385                 24390             


Ile Leu   Trp Thr Lys Val Asn   Lys Thr Ile Ile His   Asp Thr Gln 
    24395                 24400                 24405             


Phe Lys   Ala Gln Asn Leu Glu   Glu Gly Ile Glu Tyr   Glu Phe Arg 
    24410                 24415                 24420             


Val Tyr   Ala Glu Asn Ile Val   Gly Val Gly Lys Ala   Ser Lys Asn 
    24425                 24430                 24435             


Ser Glu   Cys Tyr Val Ala Arg   Asp Pro Cys Asp Pro   Pro Gly Thr 
    24440                 24445                 24450             


Pro Glu   Pro Ile Met Val Lys   Arg Asn Glu Ile Thr   Leu Gln Trp 
    24455                 24460                 24465             


Thr Lys   Pro Val Tyr Asp Gly   Gly Ser Met Ile Thr   Gly Tyr Ile 
    24470                 24475                 24480             


Val Glu   Lys Arg Asp Leu Pro   Asp Gly Arg Trp Met   Lys Ala Ser 
    24485                 24490                 24495             


Phe Thr   Asn Val Ile Glu Thr   Gln Phe Thr Val Ser   Gly Leu Thr 
    24500                 24505                 24510             


Glu Asp   Gln Arg Tyr Glu Phe   Arg Val Ile Ala Lys   Asn Ala Ala 
    24515                 24520                 24525             


Gly Ala   Ile Ser Lys Pro Ser   Asp Ser Thr Gly Pro   Ile Thr Ala 
    24530                 24535                 24540             


Lys Asp   Glu Val Glu Leu Pro   Arg Ile Ser Met Asp   Pro Lys Phe 
    24545                 24550                 24555             


Arg Asp   Thr Ile Val Val Asn   Ala Gly Glu Thr Phe   Arg Leu Glu 
    24560                 24565                 24570             


Ala Asp   Val His Gly Lys Pro   Leu Pro Thr Ile Glu   Trp Leu Arg 
    24575                 24580                 24585             


Gly Asp   Lys Glu Ile Glu Glu   Ser Ala Arg Cys Glu   Ile Lys Asn 
    24590                 24595                 24600             


Thr Asp   Phe Lys Ala Leu Leu   Ile Val Lys Asp Ala   Ile Arg Ile 
    24605                 24610                 24615             


Asp Gly   Gly Gln Tyr Ile Leu   Arg Ala Ser Asn Val   Ala Gly Ser 
    24620                 24625                 24630             


Lys Ser   Phe Pro Val Asn Val   Lys Val Leu Asp Arg   Pro Gly Pro 
    24635                 24640                 24645             


Pro Glu   Gly Pro Val Gln Val   Thr Gly Val Thr Ser   Glu Lys Cys 
    24650                 24655                 24660             


Ser Leu   Thr Trp Ser Pro Pro   Leu Gln Asp Gly Gly   Ser Asp Ile 
    24665                 24670                 24675             


Ser His   Tyr Val Val Glu Lys   Arg Glu Thr Ser Arg   Leu Ala Trp 
    24680                 24685                 24690             


Thr Val   Val Ala Ser Glu Val   Val Thr Asn Ser Leu   Lys Val Thr 
    24695                 24700                 24705             


Lys Leu   Leu Glu Gly Asn Glu   Tyr Val Phe Arg Ile   Met Ala Val 
    24710                 24715                 24720             


Asn Lys   Tyr Gly Val Gly Glu   Pro Leu Glu Ser Ala   Pro Val Leu 
    24725                 24730                 24735             


Met Lys   Asn Pro Phe Val Leu   Pro Gly Pro Pro Lys   Ser Leu Glu 
    24740                 24745                 24750             


Val Thr   Asn Ile Ala Lys Asp   Ser Met Thr Val Cys   Trp Asn Arg 
    24755                 24760                 24765             


Pro Asp   Ser Asp Gly Gly Ser   Glu Ile Ile Gly Tyr   Ile Val Glu 
    24770                 24775                 24780             


Lys Arg   Asp Arg Ser Gly Ile   Arg Trp Ile Lys Cys   Asn Lys Arg 
    24785                 24790                 24795             


Arg Ile   Thr Asp Leu Arg Leu   Arg Val Thr Gly Leu   Thr Glu Asp 
    24800                 24805                 24810             


His Glu   Tyr Glu Phe Arg Val   Ser Ala Glu Asn Ala   Ala Gly Val 
    24815                 24820                 24825             


Gly Glu   Pro Ser Pro Ala Thr   Val Tyr Tyr Lys Ala   Cys Asp Pro 
    24830                 24835                 24840             


Val Phe   Lys Pro Gly Pro Pro   Thr Asn Ala His Ile   Val Asp Thr 
    24845                 24850                 24855             


Thr Lys   Asn Ser Ile Thr Leu   Ala Trp Gly Lys Pro   Ile Tyr Asp 
    24860                 24865                 24870             


Gly Gly   Ser Glu Ile Leu Gly   Tyr Val Val Glu Ile   Cys Lys Ala 
    24875                 24880                 24885             


Asp Glu   Glu Glu Trp Gln Ile   Val Thr Pro Gln Thr   Gly Leu Arg 
    24890                 24895                 24900             


Val Thr   Arg Phe Glu Ile Ser   Lys Leu Thr Glu His   Gln Glu Tyr 
    24905                 24910                 24915             


Lys Ile   Arg Val Cys Ala Leu   Asn Lys Val Gly Leu   Gly Glu Ala 
    24920                 24925                 24930             


Thr Ser   Val Pro Gly Thr Val   Lys Pro Glu Asp Lys   Leu Glu Ala 
    24935                 24940                 24945             


Pro Glu   Leu Asp Leu Asp Ser   Glu Leu Arg Lys Gly   Ile Val Val 
    24950                 24955                 24960             


Arg Ala   Gly Gly Ser Ala Arg   Ile His Ile Pro Phe   Lys Gly Arg 
    24965                 24970                 24975             


Pro Thr   Pro Glu Ile Thr Trp   Ser Arg Glu Glu Gly   Glu Phe Thr 
    24980                 24985                 24990             


Asp Lys   Val Gln Ile Glu Lys   Gly Val Asn Tyr Thr   Gln Leu Ser 
    24995                 25000                 25005             


Ile Asp   Asn Cys Asp Arg Asn   Asp Ala Gly Lys Tyr   Ile Leu Lys 
    25010                 25015                 25020             


Leu Glu   Asn Ser Ser Gly Ser   Lys Ser Ala Phe Val   Thr Val Lys 
    25025                 25030                 25035             


Val Leu   Asp Thr Pro Gly Pro   Pro Gln Asn Leu Ala   Val Lys Glu 
    25040                 25045                 25050             


Val Arg   Lys Asp Ser Ala Phe   Leu Val Trp Glu Pro   Pro Ile Ile 
    25055                 25060                 25065             


Asp Gly   Gly Ala Lys Val Lys   Asn Tyr Val Ile Asp   Lys Arg Glu 
    25070                 25075                 25080             


Ser Thr   Arg Lys Ala Tyr Ala   Asn Val Ser Ser Lys   Cys Ser Lys 
    25085                 25090                 25095             


Thr Ser   Phe Lys Val Glu Asn   Leu Thr Glu Gly Ala   Ile Tyr Tyr 
    25100                 25105                 25110             


Phe Arg   Val Met Ala Glu Asn   Glu Phe Gly Val Gly   Val Pro Val 
    25115                 25120                 25125             


Glu Thr   Val Asp Ala Val Lys   Ala Ala Glu Pro Pro   Ser Pro Pro 
    25130                 25135                 25140             


Gly Lys   Val Thr Leu Thr Asp   Val Ser Gln Thr Ser   Ala Ser Leu 
    25145                 25150                 25155             


Met Trp   Glu Lys Pro Glu His   Asp Gly Gly Ser Arg   Val Leu Gly 
    25160                 25165                 25170             


Tyr Val   Val Glu Met Gln Pro   Lys Gly Thr Glu Lys   Trp Ser Ile 
    25175                 25180                 25185             


Val Ala   Glu Ser Lys Val Cys   Asn Ala Val Val Thr   Gly Leu Ser 
    25190                 25195                 25200             


Ser Gly   Gln Glu Tyr Gln Phe   Arg Val Lys Ala Tyr   Asn Glu Lys 
    25205                 25210                 25215             


Gly Lys   Ser Asp Pro Arg Val   Leu Gly Val Pro Val   Ile Ala Lys 
    25220                 25225                 25230             


Asp Leu   Thr Ile Gln Pro Ser   Leu Lys Leu Pro Phe   Asn Thr Tyr 
    25235                 25240                 25245             


Ser Ile   Gln Ala Gly Glu Asp   Leu Lys Ile Glu Ile   Pro Val Ile 
    25250                 25255                 25260             


Gly Arg   Pro Arg Pro Asn Ile   Ser Trp Val Lys Asp   Gly Glu Pro 
    25265                 25270                 25275             


Leu Lys   Gln Thr Thr Arg Val   Asn Val Glu Glu Thr   Ala Thr Ser 
    25280                 25285                 25290             


Thr Val   Leu His Ile Lys Glu   Gly Asn Lys Asp Asp   Phe Gly Lys 
    25295                 25300                 25305             


Tyr Thr   Val Thr Ala Thr Asn   Ser Ala Gly Thr Ala   Thr Glu Asn 
    25310                 25315                 25320             


Leu Ser   Val Ile Val Leu Glu   Lys Pro Gly Pro Pro   Val Gly Pro 
    25325                 25330                 25335             


Val Arg   Phe Asp Glu Val Ser   Ala Asp Phe Val Val   Ile Ser Trp 
    25340                 25345                 25350             


Glu Pro   Pro Ala Tyr Thr Gly   Gly Cys Gln Ile Ser   Asn Tyr Ile 
    25355                 25360                 25365             


Val Glu   Lys Arg Asp Thr Thr   Thr Thr Thr Trp His   Met Val Ser 
    25370                 25375                 25380             


Ala Thr   Val Ala Arg Thr Thr   Ile Lys Ile Thr Lys   Leu Lys Thr 
    25385                 25390                 25395             


Gly Thr   Glu Tyr Gln Phe Arg   Ile Phe Ala Glu Asn   Arg Tyr Gly 
    25400                 25405                 25410             


Lys Ser   Ala Pro Leu Asp Ser   Lys Ala Val Ile Val   Gln Tyr Pro 
    25415                 25420                 25425             


Phe Lys   Glu Pro Gly Pro Pro   Gly Thr Pro Phe Val   Thr Ser Ile 
    25430                 25435                 25440             


Ser Lys   Asp Gln Met Leu Val   Gln Trp His Glu Pro   Val Asn Asp 
    25445                 25450                 25455             


Gly Gly   Thr Lys Ile Ile Gly   Tyr His Leu Glu Gln   Lys Glu Lys 
    25460                 25465                 25470             


Asn Ser   Ile Leu Trp Val Lys   Leu Asn Lys Thr Pro   Ile Gln Asp 
    25475                 25480                 25485             


Thr Lys   Phe Lys Thr Thr Gly   Leu Asp Glu Gly Leu   Glu Tyr Glu 
    25490                 25495                 25500             


Phe Lys   Val Ser Ala Glu Asn   Ile Val Gly Ile Gly   Lys Pro Ser 
    25505                 25510                 25515             


Lys Val   Ser Glu Cys Phe Val   Ala Arg Asp Pro Cys   Asp Pro Pro 
    25520                 25525                 25530             


Gly Arg   Pro Glu Ala Ile Val   Ile Thr Arg Asn Asn   Val Thr Leu 
    25535                 25540                 25545             


Lys Trp   Lys Lys Pro Ala Tyr   Asp Gly Gly Ser Lys   Ile Thr Gly 
    25550                 25555                 25560             


Tyr Ile   Val Glu Lys Lys Asp   Leu Pro Asp Gly Arg   Trp Met Lys 
    25565                 25570                 25575             


Ala Ser   Phe Thr Asn Val Leu   Glu Thr Glu Phe Thr   Val Ser Gly 
    25580                 25585                 25590             


Leu Val   Glu Asp Gln Arg Tyr   Glu Phe Arg Val Ile   Ala Arg Asn 
    25595                 25600                 25605             


Ala Ala   Gly Asn Phe Ser Glu   Pro Ser Asp Ser Ser   Gly Ala Ile 
    25610                 25615                 25620             


Thr Ala   Arg Asp Glu Ile Asp   Ala Pro Asn Ala Ser   Leu Asp Pro 
    25625                 25630                 25635             


Lys Tyr   Lys Asp Val Ile Val   Val His Ala Gly Glu   Thr Phe Val 
    25640                 25645                 25650             


Leu Glu   Ala Asp Ile Arg Gly   Lys Pro Ile Pro Asp   Val Val Trp 
    25655                 25660                 25665             


Ser Lys   Asp Gly Lys Glu Leu   Glu Glu Thr Ala Ala   Arg Met Glu 
    25670                 25675                 25680             


Ile Lys   Ser Thr Ile Gln Lys   Thr Thr Leu Val Val   Lys Asp Cys 
    25685                 25690                 25695             


Ile Arg   Thr Asp Gly Gly Gln   Tyr Ile Leu Lys Leu   Ser Asn Val 
    25700                 25705                 25710             


Gly Gly   Thr Lys Ser Ile Pro   Ile Thr Val Lys Val   Leu Asp Arg 
    25715                 25720                 25725             


Pro Gly   Pro Pro Glu Gly Pro   Leu Lys Val Thr Gly   Val Thr Ala 
    25730                 25735                 25740             


Glu Lys   Cys Tyr Leu Ala Trp   Asn Pro Pro Leu Gln   Asp Gly Gly 
    25745                 25750                 25755             


Ala Asn   Ile Ser His Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg 
    25760                 25765                 25770             


Leu Ser   Trp Thr Gln Val Ser   Thr Glu Val Gln Ala   Leu Asn Tyr 
    25775                 25780                 25785             


Lys Val   Thr Lys Leu Leu Pro   Gly Asn Glu Tyr Ile   Phe Arg Val 
    25790                 25795                 25800             


Met Ala   Val Asn Lys Tyr Gly   Ile Gly Glu Pro Leu   Glu Ser Gly 
    25805                 25810                 25815             


Pro Val   Thr Ala Cys Asn Pro   Tyr Lys Pro Pro Gly   Pro Pro Ser 
    25820                 25825                 25830             


Thr Pro   Glu Val Ser Ala Ile   Thr Lys Asp Ser Met   Val Val Thr 
    25835                 25840                 25845             


Trp Ala   Arg Pro Val Asp Asp   Gly Gly Thr Glu Ile   Glu Gly Tyr 
    25850                 25855                 25860             


Ile Leu   Glu Lys Arg Asp Lys   Glu Gly Val Arg Trp   Thr Lys Cys 
    25865                 25870                 25875             


Asn Lys   Lys Thr Leu Thr Asp   Leu Arg Leu Arg Val   Thr Gly Leu 
    25880                 25885                 25890             


Thr Glu   Gly His Ser Tyr Glu   Phe Arg Val Ala Ala   Glu Asn Ala 
    25895                 25900                 25905             


Ala Gly   Val Gly Glu Pro Ser   Glu Pro Ser Val Phe   Tyr Arg Ala 
    25910                 25915                 25920             


Cys Asp   Ala Leu Tyr Pro Pro   Gly Pro Pro Ser Asn   Pro Lys Val 
    25925                 25930                 25935             


Thr Asp   Thr Ser Arg Ser Ser   Val Ser Leu Ala Trp   Ser Lys Pro 
    25940                 25945                 25950             


Ile Tyr   Asp Gly Gly Ala Pro   Val Lys Gly Tyr Val   Val Glu Val 
    25955                 25960                 25965             


Lys Glu   Ala Ala Ala Asp Glu   Trp Thr Thr Cys Thr   Pro Pro Thr 
    25970                 25975                 25980             


Gly Leu   Gln Gly Lys Gln Phe   Thr Val Thr Lys Leu   Lys Glu Asn 
    25985                 25990                 25995             


Thr Glu   Tyr Asn Phe Arg Ile   Cys Ala Ile Asn Ser   Glu Gly Val 
    26000                 26005                 26010             


Gly Glu   Pro Ala Thr Leu Pro   Gly Ser Val Val Ala   Gln Glu Arg 
    26015                 26020                 26025             


Ile Glu   Pro Pro Glu Ile Glu   Leu Asp Ala Asp Leu   Arg Lys Val 
    26030                 26035                 26040             


Val Val   Leu Arg Ala Ser Ala   Thr Leu Arg Leu Phe   Val Thr Ile 
    26045                 26050                 26055             


Lys Gly   Arg Pro Glu Pro Glu   Val Lys Trp Glu Lys   Ala Glu Gly 
    26060                 26065                 26070             


Ile Leu   Thr Asp Arg Ala Gln   Ile Glu Val Thr Ser   Ser Phe Thr 
    26075                 26080                 26085             


Met Leu   Val Ile Asp Asn Val   Thr Arg Phe Asp Ser   Gly Arg Tyr 
    26090                 26095                 26100             


Asn Leu   Thr Leu Glu Asn Asn   Ser Gly Ser Lys Thr   Ala Phe Val 
    26105                 26110                 26115             


Asn Val   Arg Val Leu Asp Ser   Pro Ser Ala Pro Val   Asn Leu Thr 
    26120                 26125                 26130             


Ile Arg   Glu Val Lys Lys Asp   Ser Val Thr Leu Ser   Trp Glu Pro 
    26135                 26140                 26145             


Pro Leu   Ile Asp Gly Gly Ala   Lys Ile Thr Asn Tyr   Ile Val Glu 
    26150                 26155                 26160             


Lys Arg   Glu Thr Thr Arg Lys   Ala Tyr Ala Thr Ile   Thr Asn Asn 
    26165                 26170                 26175             


Cys Thr   Lys Thr Thr Phe Arg   Ile Glu Asn Leu Gln   Glu Gly Cys 
    26180                 26185                 26190             


Ser Tyr   Tyr Phe Arg Val Leu   Ala Ser Asn Glu Tyr   Gly Ile Gly 
    26195                 26200                 26205             


Leu Pro   Ala Glu Thr Thr Glu   Pro Val Lys Val Ser   Glu Pro Pro 
    26210                 26215                 26220             


Leu Pro   Pro Gly Arg Val Thr   Leu Val Asp Val Thr   Arg Asn Thr 
    26225                 26230                 26235             


Ala Thr   Ile Lys Trp Glu Lys   Pro Glu Ser Asp Gly   Gly Ser Lys 
    26240                 26245                 26250             


Ile Thr   Gly Tyr Val Val Glu   Met Gln Thr Lys Gly   Ser Glu Lys 
    26255                 26260                 26265             


Trp Ser   Thr Cys Thr Gln Val   Lys Thr Leu Glu Ala   Thr Ile Ser 
    26270                 26275                 26280             


Gly Leu   Thr Ala Gly Glu Glu   Tyr Val Phe Arg Val   Ala Ala Val 
    26285                 26290                 26295             


Asn Glu   Lys Gly Arg Ser Asp   Pro Arg Gln Leu Gly   Val Pro Val 
    26300                 26305                 26310             


Ile Ala   Arg Asp Ile Glu Ile   Lys Pro Ser Val Glu   Leu Pro Phe 
    26315                 26320                 26325             


His Thr   Phe Asn Val Lys Ala   Arg Glu Gln Leu Lys   Ile Asp Val 
    26330                 26335                 26340             


Pro Phe   Lys Gly Arg Pro Gln   Ala Thr Val Asn Trp   Arg Lys Asp 
    26345                 26350                 26355             


Gly Gln   Thr Leu Lys Glu Thr   Thr Arg Val Asn Val   Ser Ser Ser 
    26360                 26365                 26370             


Lys Thr   Val Thr Ser Leu Ser   Ile Lys Glu Ala Ser   Lys Glu Asp 
    26375                 26380                 26385             


Val Gly   Thr Tyr Glu Leu Cys   Val Ser Asn Ser Ala   Gly Ser Ile 
    26390                 26395                 26400             


Thr Val   Pro Ile Thr Ile Ile   Val Leu Asp Arg Pro   Gly Pro Pro 
    26405                 26410                 26415             


Gly Pro   Ile Arg Ile Asp Glu   Val Ser Cys Asp Ser   Ile Thr Ile 
    26420                 26425                 26430             


Ser Trp   Asn Pro Pro Glu Tyr   Asp Gly Gly Cys Gln   Ile Ser Asn 
    26435                 26440                 26445             


Tyr Ile   Val Glu Lys Lys Glu   Thr Thr Ser Thr Thr   Trp His Ile 
    26450                 26455                 26460             


Val Ser   Gln Ala Val Ala Arg   Thr Ser Ile Lys Ile   Val Arg Leu 
    26465                 26470                 26475             


Thr Thr   Gly Ser Glu Tyr Gln   Phe Arg Val Cys Ala   Glu Asn Arg 
    26480                 26485                 26490             


Tyr Gly   Lys Ser Ser Tyr Ser   Glu Ser Ser Ala Val   Val Ala Glu 
    26495                 26500                 26505             


Tyr Pro   Phe Ser Pro Pro Gly   Pro Pro Gly Thr Pro   Lys Val Val 
    26510                 26515                 26520             


His Ala   Thr Lys Ser Thr Met   Leu Val Thr Trp Gln   Val Pro Val 
    26525                 26530                 26535             


Asn Asp   Gly Gly Ser Arg Val   Ile Gly Tyr His Leu   Glu Tyr Lys 
    26540                 26545                 26550             


Glu Arg   Ser Ser Ile Leu Trp   Ser Lys Ala Asn Lys   Ile Leu Ile 
    26555                 26560                 26565             


Ala Asp   Thr Gln Met Lys Val   Ser Gly Leu Asp Glu   Gly Leu Met 
    26570                 26575                 26580             


Tyr Glu   Tyr Arg Val Tyr Ala   Glu Asn Ile Ala Gly   Ile Gly Lys 
    26585                 26590                 26595             


Cys Ser   Lys Ser Cys Glu Pro   Val Pro Ala Arg Asp   Pro Cys Asp 
    26600                 26605                 26610             


Pro Pro   Gly Gln Pro Glu Val   Thr Asn Ile Thr Arg   Lys Ser Val 
    26615                 26620                 26625             


Ser Leu   Lys Trp Ser Lys Pro   His Tyr Asp Gly Gly   Ala Lys Ile 
    26630                 26635                 26640             


Thr Gly   Tyr Ile Val Glu Arg   Arg Glu Leu Pro Asp   Gly Arg Trp 
    26645                 26650                 26655             


Leu Lys   Cys Asn Tyr Thr Asn   Ile Gln Glu Thr Tyr   Phe Glu Val 
    26660                 26665                 26670             


Thr Glu   Leu Thr Glu Asp Gln   Arg Tyr Glu Phe Arg   Val Phe Ala 
    26675                 26680                 26685             


Arg Asn   Ala Ala Asp Ser Val   Ser Glu Pro Ser Glu   Ser Thr Gly 
    26690                 26695                 26700             


Pro Ile   Ile Val Lys Asp Asp   Val Glu Pro Pro Arg   Val Met Met 
    26705                 26710                 26715             


Asp Val   Lys Phe Arg Asp Val   Ile Val Val Lys Ala   Gly Glu Val 
    26720                 26725                 26730             


Leu Lys   Ile Asn Ala Asp Ile   Ala Gly Arg Pro Leu   Pro Val Ile 
    26735                 26740                 26745             


Ser Trp   Ala Lys Asp Gly Ile   Glu Ile Glu Glu Arg   Ala Arg Thr 
    26750                 26755                 26760             


Glu Ile   Ile Ser Thr Asp Asn   His Thr Leu Leu Thr   Val Lys Asp 
    26765                 26770                 26775             


Cys Ile   Arg Arg Asp Thr Gly   Gln Tyr Val Leu Thr   Leu Lys Asn 
    26780                 26785                 26790             


Val Ala   Gly Thr Arg Ser Val   Ala Val Asn Cys Lys   Val Leu Asp 
    26795                 26800                 26805             


Lys Pro   Gly Pro Pro Ala Gly   Pro Leu Glu Ile Asn   Gly Leu Thr 
    26810                 26815                 26820             


Ala Glu   Lys Cys Ser Leu Ser   Trp Gly Arg Pro Gln   Glu Asp Gly 
    26825                 26830                 26835             


Gly Ala   Asp Ile Asp Tyr Tyr   Ile Val Glu Lys Arg   Glu Thr Ser 
    26840                 26845                 26850             


His Leu   Ala Trp Thr Ile Cys   Glu Gly Glu Leu Gln   Met Thr Ser 
    26855                 26860                 26865             


Cys Lys   Val Thr Lys Leu Leu   Lys Gly Asn Glu Tyr   Ile Phe Arg 
    26870                 26875                 26880             


Val Thr   Gly Val Asn Lys Tyr   Gly Val Gly Glu Pro   Leu Glu Ser 
    26885                 26890                 26895             


Val Ala   Ile Lys Ala Leu Asp   Pro Phe Thr Val Pro   Ser Pro Pro 
    26900                 26905                 26910             


Thr Ser   Leu Glu Ile Thr Ser   Val Thr Lys Glu Ser   Met Thr Leu 
    26915                 26920                 26925             


Cys Trp   Ser Arg Pro Glu Ser   Asp Gly Gly Ser Glu   Ile Ser Gly 
    26930                 26935                 26940             


Tyr Ile   Ile Glu Arg Arg Glu   Lys Asn Ser Leu Arg   Trp Val Arg 
    26945                 26950                 26955             


Val Asn   Lys Lys Pro Val Tyr   Asp Leu Arg Val Lys   Ser Thr Gly 
    26960                 26965                 26970             


Leu Arg   Glu Gly Cys Glu Tyr   Glu Tyr Arg Val Tyr   Ala Glu Asn 
    26975                 26980                 26985             


Ala Ala   Gly Leu Ser Leu Pro   Ser Glu Thr Ser Pro   Leu Ile Arg 
    26990                 26995                 27000             


Ala Glu   Asp Pro Val Phe Leu   Pro Ser Pro Pro Ser   Lys Pro Lys 
    27005                 27010                 27015             


Ile Val   Asp Ser Gly Lys Thr   Thr Ile Thr Ile Ala   Trp Val Lys 
    27020                 27025                 27030             


Pro Leu   Phe Asp Gly Gly Ala   Pro Ile Thr Gly Tyr   Thr Val Glu 
    27035                 27040                 27045             


Tyr Lys   Lys Ser Asp Asp Thr   Asp Trp Lys Thr Ser   Ile Gln Ser 
    27050                 27055                 27060             


Leu Arg   Gly Thr Glu Tyr Thr   Ile Ser Gly Leu Thr   Thr Gly Ala 
    27065                 27070                 27075             


Glu Tyr   Val Phe Arg Val Lys   Ser Val Asn Lys Val   Gly Ala Ser 
    27080                 27085                 27090             


Asp Pro   Ser Asp Ser Ser Asp   Pro Gln Ile Ala Lys   Glu Arg Glu 
    27095                 27100                 27105             


Glu Glu   Pro Leu Phe Asp Ile   Asp Ser Glu Met Arg   Lys Thr Leu 
    27110                 27115                 27120             


Ile Val   Lys Ala Gly Ala Ser   Phe Thr Met Thr Val   Pro Phe Arg 
    27125                 27130                 27135             


Gly Arg   Pro Val Pro Asn Val   Leu Trp Ser Lys Pro   Asp Thr Asp 
    27140                 27145                 27150             


Leu Arg   Thr Arg Ala Tyr Val   Asp Thr Thr Asp Ser   Arg Thr Ser 
    27155                 27160                 27165             


Leu Thr   Ile Glu Asn Ala Asn   Arg Asn Asp Ser Gly   Lys Tyr Thr 
    27170                 27175                 27180             


Leu Thr   Ile Gln Asn Val Leu   Ser Ala Ala Ser Leu   Thr Leu Val 
    27185                 27190                 27195             


Val Lys   Val Leu Asp Thr Pro   Gly Pro Pro Thr Asn   Ile Thr Val 
    27200                 27205                 27210             


Gln Asp   Val Thr Lys Glu Ser   Ala Val Leu Ser Trp   Asp Val Pro 
    27215                 27220                 27225             


Glu Asn   Asp Gly Gly Ala Pro   Val Lys Asn Tyr His   Ile Glu Lys 
    27230                 27235                 27240             


Arg Glu   Ala Ser Lys Lys Ala   Trp Val Ser Val Thr   Asn Asn Cys 
    27245                 27250                 27255             


Asn Arg   Leu Ser Tyr Lys Val   Thr Asn Leu Gln Glu   Gly Ala Ile 
    27260                 27265                 27270             


Tyr Tyr   Phe Arg Val Ser Gly   Glu Asn Glu Phe Gly   Val Gly Ile 
    27275                 27280                 27285             


Pro Ala   Glu Thr Lys Glu Gly   Val Lys Ile Thr Glu   Lys Pro Ser 
    27290                 27295                 27300             


Pro Pro   Glu Lys Leu Gly Val   Thr Ser Ile Ser Lys   Asp Ser Val 
    27305                 27310                 27315             


Ser Leu   Thr Trp Leu Lys Pro   Glu His Asp Gly Gly   Ser Arg Ile 
    27320                 27325                 27330             


Val His   Tyr Val Val Glu Ala   Leu Glu Lys Gly Gln   Lys Asn Trp 
    27335                 27340                 27345             


Val Lys   Cys Ala Val Ala Lys   Ser Thr His His Val   Val Ser Gly 
    27350                 27355                 27360             


Leu Arg   Glu Asn Ser Glu Tyr   Phe Phe Arg Val Phe   Ala Glu Asn 
    27365                 27370                 27375             


Gln Ala   Gly Leu Ser Asp Pro   Arg Glu Leu Leu Leu   Pro Val Leu 
    27380                 27385                 27390             


Ile Lys   Glu Gln Leu Glu Pro   Pro Glu Ile Asp Met   Lys Asn Phe 
    27395                 27400                 27405             


Pro Ser   His Thr Val Tyr Val   Arg Ala Gly Ser Asn   Leu Lys Val 
    27410                 27415                 27420             


Asp Ile   Pro Ile Ser Gly Lys   Pro Leu Pro Lys Val   Thr Leu Ser 
    27425                 27430                 27435             


Arg Asp   Gly Val Pro Leu Lys   Ala Thr Met Arg Phe   Asn Thr Glu 
    27440                 27445                 27450             


Ile Thr   Ala Glu Asn Leu Thr   Ile Asn Leu Lys Glu   Ser Val Thr 
    27455                 27460                 27465             


Ala Asp   Ala Gly Arg Tyr Glu   Ile Thr Ala Ala Asn   Ser Ser Gly 
    27470                 27475                 27480             


Thr Thr   Lys Ala Phe Ile Asn   Ile Val Val Leu Asp   Arg Pro Gly 
    27485                 27490                 27495             


Pro Pro   Thr Gly Pro Val Val   Ile Ser Asp Ile Thr   Glu Glu Ser 
    27500                 27505                 27510             


Val Thr   Leu Lys Trp Glu Pro   Pro Lys Tyr Asp Gly   Gly Ser Gln 
    27515                 27520                 27525             


Val Thr   Asn Tyr Ile Leu Leu   Lys Arg Glu Thr Ser   Thr Ala Val 
    27530                 27535                 27540             


Trp Thr   Glu Val Ser Ala Thr   Val Ala Arg Thr Met   Met Lys Val 
    27545                 27550                 27555             


Met Lys   Leu Thr Thr Gly Glu   Glu Tyr Gln Phe Arg   Ile Lys Ala 
    27560                 27565                 27570             


Glu Asn   Arg Phe Gly Ile Ser   Asp His Ile Asp Ser   Ala Cys Val 
    27575                 27580                 27585             


Thr Val   Lys Leu Pro Tyr Thr   Thr Pro Gly Pro Pro   Ser Thr Pro 
    27590                 27595                 27600             


Trp Val   Thr Asn Val Thr Arg   Glu Ser Ile Thr Val   Gly Trp His 
    27605                 27610                 27615             


Glu Pro   Val Ser Asn Gly Gly   Ser Ala Val Val Gly   Tyr His Leu 
    27620                 27625                 27630             


Glu Met   Lys Asp Arg Asn Ser   Ile Leu Trp Gln Lys   Ala Asn Lys 
    27635                 27640                 27645             


Leu Val   Ile Arg Thr Thr His   Phe Lys Val Thr Thr   Ile Ser Ala 
    27650                 27655                 27660             


Gly Leu   Ile Tyr Glu Phe Arg   Val Tyr Ala Glu Asn   Ala Ala Gly 
    27665                 27670                 27675             


Val Gly   Lys Pro Ser His Pro   Ser Glu Pro Val Leu   Ala Ile Asp 
    27680                 27685                 27690             


Ala Cys   Glu Pro Pro Arg Asn   Val Arg Ile Thr Asp   Ile Ser Lys 
    27695                 27700                 27705             


Asn Ser   Val Ser Leu Ser Trp   Gln Gln Pro Ala Phe   Asp Gly Gly 
    27710                 27715                 27720             


Ser Lys   Ile Thr Gly Tyr Ile   Val Glu Arg Arg Asp   Leu Pro Asp 
    27725                 27730                 27735             


Gly Arg   Trp Thr Lys Ala Ser   Phe Thr Asn Val Thr   Glu Thr Gln 
    27740                 27745                 27750             


Phe Ile   Ile Ser Gly Leu Thr   Gln Asn Ser Gln Tyr   Glu Phe Arg 
    27755                 27760                 27765             


Val Phe   Ala Arg Asn Ala Val   Gly Ser Ile Ser Asn   Pro Ser Glu 
    27770                 27775                 27780             


Val Val   Gly Pro Ile Thr Cys   Ile Asp Ser Tyr Gly   Gly Pro Val 
    27785                 27790                 27795             


Ile Asp   Leu Pro Leu Glu Tyr   Thr Glu Val Val Lys   Tyr Arg Ala 
    27800                 27805                 27810             


Gly Thr   Ser Val Lys Leu Arg   Ala Gly Ile Ser Gly   Lys Pro Ala 
    27815                 27820                 27825             


Pro Thr   Ile Glu Trp Tyr Lys   Asp Asp Lys Glu Leu   Gln Thr Asn 
    27830                 27835                 27840             


Ala Leu   Val Cys Val Glu Asn   Thr Thr Asp Leu Ala   Ser Ile Leu 
    27845                 27850                 27855             


Ile Lys   Asp Ala Asp Arg Leu   Asn Ser Gly Cys Tyr   Glu Leu Lys 
    27860                 27865                 27870             


Leu Arg   Asn Ala Met Gly Ser   Ala Ser Ala Thr Ile   Arg Val Gln 
    27875                 27880                 27885             


Ile Leu   Asp Lys Pro Gly Pro   Pro Gly Gly Pro Ile   Glu Phe Lys 
    27890                 27895                 27900             


Thr Val   Thr Ala Glu Lys Ile   Thr Leu Leu Trp Arg   Pro Pro Ala 
    27905                 27910                 27915             


Asp Asp   Gly Gly Ala Lys Ile   Thr His Tyr Ile Val   Glu Lys Arg 
    27920                 27925                 27930             


Glu Thr   Ser Arg Val Val Trp   Ser Met Val Ser Glu   His Leu Glu 
    27935                 27940                 27945             


Glu Cys   Ile Ile Thr Thr Thr   Lys Ile Ile Lys Gly   Asn Glu Tyr 
    27950                 27955                 27960             


Ile Phe   Arg Val Arg Ala Val   Asn Lys Tyr Gly Ile   Gly Glu Pro 
    27965                 27970                 27975             


Leu Glu   Ser Asp Ser Val Val   Ala Lys Asn Ala Phe   Val Thr Pro 
    27980                 27985                 27990             


Gly Pro   Pro Gly Ile Pro Glu   Val Thr Lys Ile Thr   Lys Asn Ser 
    27995                 28000                 28005             


Met Thr   Val Val Trp Ser Arg   Pro Ile Ala Asp Gly   Gly Ser Asp 
    28010                 28015                 28020             


Ile Ser   Gly Tyr Phe Leu Glu   Lys Arg Asp Lys Lys   Ser Leu Gly 
    28025                 28030                 28035             


Trp Phe   Lys Val Leu Lys Glu   Thr Ile Arg Asp Thr   Arg Gln Lys 
    28040                 28045                 28050             


Val Thr   Gly Leu Thr Glu Asn   Ser Asp Tyr Gln Tyr   Arg Val Cys 
    28055                 28060                 28065             


Ala Val   Asn Ala Ala Gly Gln   Gly Pro Phe Ser Glu   Pro Ser Glu 
    28070                 28075                 28080             


Phe Tyr   Lys Ala Ala Asp Pro   Ile Asp Pro Pro Gly   Pro Pro Ala 
    28085                 28090                 28095             


Lys Ile   Arg Ile Ala Asp Ser   Thr Lys Ser Ser Ile   Thr Leu Gly 
    28100                 28105                 28110             


Trp Ser   Lys Pro Val Tyr Asp   Gly Gly Ser Ala Val   Thr Gly Tyr 
    28115                 28120                 28125             


Val Val   Glu Ile Arg Gln Gly   Glu Glu Glu Glu Trp   Thr Thr Val 
    28130                 28135                 28140             


Ser Thr   Lys Gly Glu Val Arg   Thr Thr Glu Tyr Val   Val Ser Asn 
    28145                 28150                 28155             


Leu Lys   Pro Gly Val Asn Tyr   Tyr Phe Arg Val Ser   Ala Val Asn 
    28160                 28165                 28170             


Cys Ala   Gly Gln Gly Glu Pro   Ile Glu Met Asn Glu   Pro Val Gln 
    28175                 28180                 28185             


Ala Lys   Asp Ile Leu Glu Ala   Pro Glu Ile Asp Leu   Asp Val Ala 
    28190                 28195                 28200             


Leu Arg   Thr Ser Val Ile Ala   Lys Ala Gly Glu Asp   Val Gln Val 
    28205                 28210                 28215             


Leu Ile   Pro Phe Lys Gly Arg   Pro Pro Pro Thr Val   Thr Trp Arg 
    28220                 28225                 28230             


Lys Asp   Glu Lys Asn Leu Gly   Ser Asp Ala Arg Tyr   Ser Ile Glu 
    28235                 28240                 28245             


Asn Thr   Asp Ser Ser Ser Leu   Leu Thr Ile Pro Gln   Val Thr Arg 
    28250                 28255                 28260             


Asn Asp   Thr Gly Lys Tyr Ile   Leu Thr Ile Glu Asn   Gly Val Gly 
    28265                 28270                 28275             


Glu Pro   Lys Ser Ser Thr Val   Ser Val Lys Val Leu   Asp Thr Pro 
    28280                 28285                 28290             


Ala Ala   Cys Gln Lys Leu Gln   Val Lys His Val Ser   Arg Gly Thr 
    28295                 28300                 28305             


Val Thr   Leu Leu Trp Asp Pro   Pro Leu Ile Asp Gly   Gly Ser Pro 
    28310                 28315                 28320             


Ile Ile   Asn Tyr Val Ile Glu   Lys Arg Asp Ala Thr   Lys Arg Thr 
    28325                 28330                 28335             


Trp Ser   Val Val Ser His Lys   Cys Ser Ser Thr Ser   Phe Lys Leu 
    28340                 28345                 28350             


Ile Asp   Leu Ser Glu Lys Thr   Pro Phe Phe Phe Arg   Val Leu Ala 
    28355                 28360                 28365             


Glu Asn   Glu Ile Gly Ile Gly   Glu Pro Cys Glu Thr   Thr Glu Pro 
    28370                 28375                 28380             


Val Lys   Ala Ala Glu Val Pro   Ala Pro Ile Arg Asp   Leu Ser Met 
    28385                 28390                 28395             


Lys Asp   Ser Thr Lys Thr Ser   Val Ile Leu Ser Trp   Thr Lys Pro 
    28400                 28405                 28410             


Asp Phe   Asp Gly Gly Ser Val   Ile Thr Glu Tyr Val   Val Glu Arg 
    28415                 28420                 28425             


Lys Gly   Lys Gly Glu Gln Thr   Trp Ser His Ala Gly   Ile Ser Lys 
    28430                 28435                 28440             


Thr Cys   Glu Ile Glu Val Ser   Gln Leu Lys Glu Gln   Ser Val Leu 
    28445                 28450                 28455             


Glu Phe   Arg Val Phe Ala Lys   Asn Glu Lys Gly Leu   Ser Asp Pro 
    28460                 28465                 28470             


Val Thr   Ile Gly Pro Ile Thr   Val Lys Glu Leu Ile   Ile Thr Pro 
    28475                 28480                 28485             


Glu Val   Asp Leu Ser Asp Ile   Pro Gly Ala Gln Val   Thr Val Arg 
    28490                 28495                 28500             


Ile Gly   His Asn Val His Leu   Glu Leu Pro Tyr Lys   Gly Lys Pro 
    28505                 28510                 28515             


Lys Pro   Ser Ile Ser Trp Leu   Lys Asp Gly Leu Pro   Leu Lys Glu 
    28520                 28525                 28530             


Ser Glu   Phe Val Arg Phe Ser   Lys Thr Glu Asn Lys   Ile Thr Leu 
    28535                 28540                 28545             


Ser Ile   Lys Asn Ala Lys Lys   Glu His Gly Gly Lys   Tyr Thr Val 
    28550                 28555                 28560             


Ile Leu   Asp Asn Ala Val Cys   Arg Ile Ala Val Pro   Ile Thr Val 
    28565                 28570                 28575             


Ile Thr   Leu Gly Pro Pro Ser   Lys Pro Lys Gly Pro   Ile Arg Phe 
    28580                 28585                 28590             


Asp Glu   Ile Lys Ala Asp Ser   Val Ile Leu Ser Trp   Asp Val Pro 
    28595                 28600                 28605             


Glu Asp   Asn Gly Gly Gly Glu   Ile Thr Cys Tyr Ser   Ile Glu Lys 
    28610                 28615                 28620             


Arg Glu   Thr Ser Gln Thr Asn   Trp Lys Met Val Cys   Ser Ser Val 
    28625                 28630                 28635             


Ala Arg   Thr Thr Phe Lys Val   Pro Asn Leu Val Lys   Asp Ala Glu 
    28640                 28645                 28650             


Tyr Gln   Phe Arg Val Arg Ala   Glu Asn Arg Tyr Gly   Val Ser Gln 
    28655                 28660                 28665             


Pro Leu   Val Ser Ser Ile Ile   Val Ala Lys His Gln   Phe Arg Ile 
    28670                 28675                 28680             


Pro Gly   Pro Pro Gly Lys Pro   Val Ile Tyr Asn Val   Thr Ser Asp 
    28685                 28690                 28695             


Gly Met   Ser Leu Thr Trp Asp   Ala Pro Val Tyr Asp   Gly Gly Ser 
    28700                 28705                 28710             


Glu Val   Thr Gly Phe His Val   Glu Lys Lys Glu Arg   Asn Ser Ile 
    28715                 28720                 28725             


Leu Trp   Gln Lys Val Asn Thr   Ser Pro Ile Ser Gly   Arg Glu Tyr 
    28730                 28735                 28740             


Arg Ala   Thr Gly Leu Val Glu   Gly Leu Asp Tyr Gln   Phe Arg Val 
    28745                 28750                 28755             


Tyr Ala   Glu Asn Ser Ala Gly   Leu Ser Ser Pro Ser   Asp Pro Ser 
    28760                 28765                 28770             


Lys Phe   Thr Leu Ala Val Ser   Pro Val Asp Pro Pro   Gly Thr Pro 
    28775                 28780                 28785             


Asp Tyr   Ile Asp Val Thr Arg   Glu Thr Ile Thr Leu   Lys Trp Asn 
    28790                 28795                 28800             


Pro Pro   Leu Arg Asp Gly Gly   Ser Lys Ile Val Gly   Tyr Ser Ile 
    28805                 28810                 28815             


Glu Lys   Arg Gln Gly Asn Glu   Arg Trp Val Arg Cys   Asn Phe Thr 
    28820                 28825                 28830             


Asp Val   Ser Glu Cys Gln Tyr   Thr Val Thr Gly Leu   Ser Pro Gly 
    28835                 28840                 28845             


Asp Arg   Tyr Glu Phe Arg Ile   Ile Ala Arg Asn Ala   Val Gly Thr 
    28850                 28855                 28860             


Ile Ser   Pro Pro Ser Gln Ser   Ser Gly Ile Ile Met   Thr Arg Asp 
    28865                 28870                 28875             


Glu Asn   Val Pro Pro Ile Val   Glu Phe Gly Pro Glu   Tyr Phe Asp 
    28880                 28885                 28890             


Gly Leu   Ile Ile Lys Ser Gly   Glu Ser Leu Arg Ile   Lys Ala Leu 
    28895                 28900                 28905             


Val Gln   Gly Arg Pro Val Pro   Arg Val Thr Trp Phe   Lys Asp Gly 
    28910                 28915                 28920             


Val Glu   Ile Glu Lys Arg Met   Asn Met Glu Ile Thr   Asp Val Leu 
    28925                 28930                 28935             


Gly Ser   Thr Ser Leu Phe Val   Arg Asp Ala Thr Arg   Asp His Arg 
    28940                 28945                 28950             


Gly Val   Tyr Thr Val Glu Ala   Lys Asn Ala Ser Gly   Ser Ala Lys 
    28955                 28960                 28965             


Ala Glu   Ile Lys Val Lys Val   Gln Asp Thr Pro Gly   Lys Val Val 
    28970                 28975                 28980             


Gly Pro   Ile Arg Phe Thr Asn   Ile Thr Gly Glu Lys   Met Thr Leu 
    28985                 28990                 28995             


Trp Trp   Asp Ala Pro Leu Asn   Asp Gly Cys Ala Pro   Ile Thr His 
    29000                 29005                 29010             


Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg Leu Ala   Trp Ala Leu 
    29015                 29020                 29025             


Ile Glu   Asp Lys Cys Glu Ala   Gln Ser Tyr Thr Ala   Ile Lys Leu 
    29030                 29035                 29040             


Ile Asn   Gly Asn Glu Tyr Gln   Phe Arg Val Ser Ala   Val Asn Lys 
    29045                 29050                 29055             


Phe Gly   Val Gly Arg Pro Leu   Asp Ser Asp Pro Val   Val Ala Gln 
    29060                 29065                 29070             


Ile Gln   Tyr Thr Val Pro Asp   Ala Pro Gly Ile Pro   Glu Pro Ser 
    29075                 29080                 29085             


Asn Ile   Thr Gly Asn Ser Ile   Thr Leu Thr Trp Ala   Arg Pro Glu 
    29090                 29095                 29100             


Ser Asp   Gly Gly Ser Glu Ile   Gln Gln Tyr Ile Leu   Glu Arg Arg 
    29105                 29110                 29115             


Glu Lys   Lys Ser Thr Arg Trp   Val Lys Val Ile Ser   Lys Arg Pro 
    29120                 29125                 29130             


Ile Ser   Glu Thr Arg Phe Lys   Val Thr Gly Leu Thr   Glu Gly Asn 
    29135                 29140                 29145             


Glu Tyr   Glu Phe His Val Met   Ala Glu Asn Ala Ala   Gly Val Gly 
    29150                 29155                 29160             


Pro Ala   Ser Gly Ile Ser Arg   Leu Ile Lys Cys Arg   Glu Pro Val 
    29165                 29170                 29175             


Asn Pro   Pro Gly Pro Pro Thr   Val Val Lys Val Thr   Asp Thr Ser 
    29180                 29185                 29190             


Lys Thr   Thr Val Ser Leu Glu   Trp Ser Lys Pro Val   Phe Asp Gly 
    29195                 29200                 29205             


Gly Met   Glu Ile Ile Gly Tyr   Ile Ile Glu Met Cys   Lys Ala Asp 
    29210                 29215                 29220             


Leu Gly   Asp Trp His Lys Val   Asn Ala Glu Ala Cys   Val Lys Thr 
    29225                 29230                 29235             


Arg Tyr   Thr Val Thr Asp Leu   Gln Ala Gly Glu Glu   Tyr Lys Phe 
    29240                 29245                 29250             


Arg Val   Ser Ala Ile Asn Gly   Ala Gly Lys Gly Asp   Ser Cys Glu 
    29255                 29260                 29265             


Val Thr   Gly Thr Ile Lys Ala   Val Asp Arg Leu Thr   Ala Pro Glu 
    29270                 29275                 29280             


Leu Asp   Ile Asp Ala Asn Phe   Lys Gln Thr His Val   Val Arg Ala 
    29285                 29290                 29295             


Gly Ala   Ser Ile Arg Leu Phe   Ile Ala Tyr Gln Gly   Arg Pro Thr 
    29300                 29305                 29310             


Pro Thr   Ala Val Trp Ser Lys   Pro Asp Ser Asn Leu   Ser Leu Arg 
    29315                 29320                 29325             


Ala Asp   Ile His Thr Thr Asp   Ser Phe Ser Thr Leu   Thr Val Glu 
    29330                 29335                 29340             


Asn Cys   Asn Arg Asn Asp Ala   Gly Lys Tyr Thr Leu   Thr Val Glu 
    29345                 29350                 29355             


Asn Asn   Ser Gly Ser Lys Ser   Ile Thr Phe Thr Val   Lys Val Leu 
    29360                 29365                 29370             


Asp Thr   Pro Gly Pro Pro Gly   Pro Ile Thr Phe Lys   Asp Val Thr 
    29375                 29380                 29385             


Arg Gly   Ser Ala Thr Leu Met   Trp Asp Ala Pro Leu   Leu Asp Gly 
    29390                 29395                 29400             


Gly Ala   Arg Ile His His Tyr   Val Val Glu Lys Arg   Glu Ala Ser 
    29405                 29410                 29415             


Arg Arg   Ser Trp Gln Val Ile   Ser Glu Lys Cys Thr   Arg Gln Ile 
    29420                 29425                 29430             


Phe Lys   Val Asn Asp Leu Ala   Glu Gly Val Pro Tyr   Tyr Phe Arg 
    29435                 29440                 29445             


Val Ser   Ala Val Asn Glu Tyr   Gly Val Gly Glu Pro   Tyr Glu Met 
    29450                 29455                 29460             


Pro Glu   Pro Ile Val Ala Thr   Glu Gln Pro Ala Pro   Pro Arg Arg 
    29465                 29470                 29475             


Leu Asp   Val Val Asp Thr Ser   Lys Ser Ser Ala Val   Leu Ala Trp 
    29480                 29485                 29490             


Leu Lys   Pro Asp His Asp Gly   Gly Ser Arg Ile Thr   Gly Tyr Leu 
    29495                 29500                 29505             


Leu Glu   Met Arg Gln Lys Gly   Ser Asp Phe Trp Val   Glu Ala Gly 
    29510                 29515                 29520             


His Thr   Lys Gln Leu Thr Phe   Thr Val Glu Arg Leu   Val Glu Lys 
    29525                 29530                 29535             


Thr Glu   Tyr Glu Phe Arg Val   Lys Ala Lys Asn Asp   Ala Gly Tyr 
    29540                 29545                 29550             


Ser Glu   Pro Arg Glu Ala Phe   Ser Ser Val Ile Ile   Lys Glu Pro 
    29555                 29560                 29565             


Gln Ile   Glu Pro Thr Ala Asp   Leu Thr Gly Ile Thr   Asn Gln Leu 
    29570                 29575                 29580             


Ile Thr   Cys Lys Ala Gly Ser   Pro Phe Thr Ile Asp   Val Pro Ile 
    29585                 29590                 29595             


Ser Gly   Arg Pro Ala Pro Lys   Val Thr Trp Lys Leu   Glu Glu Met 
    29600                 29605                 29610             


Arg Leu   Lys Glu Thr Asp Arg   Val Ser Ile Thr Thr   Thr Lys Asp 
    29615                 29620                 29625             


Arg Thr   Thr Leu Thr Val Lys   Asp Ser Met Arg Gly   Asp Ser Gly 
    29630                 29635                 29640             


Arg Tyr   Phe Leu Thr Leu Glu   Asn Thr Ala Gly Val   Lys Thr Phe 
    29645                 29650                 29655             


Ser Val   Thr Val Val Val Ile   Gly Arg Pro Gly Pro   Val Thr Gly 
    29660                 29665                 29670             


Pro Ile   Glu Val Ser Ser Val   Ser Ala Glu Ser Cys   Val Leu Ser 
    29675                 29680                 29685             


Trp Gly   Glu Pro Lys Asp Gly   Gly Gly Thr Glu Ile   Thr Asn Tyr 
    29690                 29695                 29700             


Ile Val   Glu Lys Arg Glu Ser   Gly Thr Thr Ala Trp   Gln Leu Val 
    29705                 29710                 29715             


Asn Ser   Ser Val Lys Arg Thr   Gln Ile Lys Val Thr   His Leu Thr 
    29720                 29725                 29730             


Lys Tyr   Met Glu Tyr Ser Phe   Arg Val Ser Ser Glu   Asn Arg Phe 
    29735                 29740                 29745             


Gly Val   Ser Lys Pro Leu Glu   Ser Ala Pro Ile Ile   Ala Glu His 
    29750                 29755                 29760             


Pro Phe   Val Pro Pro Ser Ala   Pro Thr Arg Pro Glu   Val Tyr His 
    29765                 29770                 29775             


Val Ser   Ala Asn Ala Met Ser   Ile Arg Trp Glu Glu   Pro Tyr His 
    29780                 29785                 29790             


Asp Gly   Gly Ser Lys Ile Ile   Gly Tyr Trp Val Glu   Lys Lys Glu 
    29795                 29800                 29805             


Arg Asn   Thr Ile Leu Trp Val   Lys Glu Asn Lys Val   Pro Cys Leu 
    29810                 29815                 29820             


Glu Cys   Asn Tyr Lys Val Thr   Gly Leu Val Glu Gly   Leu Glu Tyr 
    29825                 29830                 29835             


Gln Phe   Arg Thr Tyr Ala Leu   Asn Ala Ala Gly Val   Ser Lys Ala 
    29840                 29845                 29850             


Ser Glu   Ala Ser Arg Pro Ile   Met Ala Gln Asn Pro   Val Asp Ala 
    29855                 29860                 29865             


Pro Gly   Arg Pro Glu Val Thr   Asp Val Thr Arg Ser   Thr Val Ser 
    29870                 29875                 29880             


Leu Ile   Trp Ser Ala Pro Ala   Tyr Asp Gly Gly Ser   Lys Val Val 
    29885                 29890                 29895             


Gly Tyr   Ile Ile Glu Arg Lys   Pro Val Ser Glu Val   Gly Asp Gly 
    29900                 29905                 29910             


Arg Trp   Leu Lys Cys Asn Tyr   Thr Ile Val Ser Asp   Asn Phe Phe 
    29915                 29920                 29925             


Thr Val   Thr Ala Leu Ser Glu   Gly Asp Thr Tyr Glu   Phe Arg Val 
    29930                 29935                 29940             


Leu Ala   Lys Asn Ala Ala Gly   Val Ile Ser Lys Gly   Ser Glu Ser 
    29945                 29950                 29955             


Thr Gly   Pro Val Thr Cys Arg   Asp Glu Tyr Ala Pro   Pro Lys Ala 
    29960                 29965                 29970             


Glu Leu   Asp Ala Arg Leu His   Gly Asp Leu Val Thr   Ile Arg Ala 
    29975                 29980                 29985             


Gly Ser   Asp Leu Val Leu Asp   Ala Ala Val Gly Gly   Lys Pro Glu 
    29990                 29995                 30000             


Pro Lys   Ile Ile Trp Thr Lys   Gly Asp Lys Glu Leu   Asp Leu Cys 
    30005                 30010                 30015             


Glu Lys   Val Ser Leu Gln Tyr   Thr Gly Lys Arg Ala   Thr Ala Val 
    30020                 30025                 30030             


Ile Lys   Phe Cys Asp Arg Ser   Asp Ser Gly Lys Tyr   Thr Leu Thr 
    30035                 30040                 30045             


Val Lys   Asn Ala Ser Gly Thr   Lys Ala Val Ser Val   Met Val Lys 
    30050                 30055                 30060             


Val Leu   Asp Ser Pro Gly Pro   Cys Gly Lys Leu Thr   Val Ser Arg 
    30065                 30070                 30075             


Val Thr   Gln Glu Lys Cys Thr   Leu Ala Trp Ser Leu   Pro Gln Glu 
    30080                 30085                 30090             


Asp Gly   Gly Ala Glu Ile Thr   His Tyr Ile Val Glu   Arg Arg Glu 
    30095                 30100                 30105             


Thr Ser   Arg Leu Asn Trp Val   Ile Val Glu Gly Glu   Cys Pro Thr 
    30110                 30115                 30120             


Leu Ser   Tyr Val Val Thr Arg   Leu Ile Lys Asn Asn   Glu Tyr Ile 
    30125                 30130                 30135             


Phe Arg   Val Arg Ala Val Asn   Lys Tyr Gly Pro Gly   Val Pro Val 
    30140                 30145                 30150             


Glu Ser   Glu Pro Ile Val Ala   Arg Asn Ser Phe Thr   Ile Pro Ser 
    30155                 30160                 30165             


Pro Pro   Gly Ile Pro Glu Glu   Val Gly Thr Gly Lys   Glu His Ile 
    30170                 30175                 30180             


Ile Ile   Gln Trp Thr Lys Pro   Glu Ser Asp Gly Gly   Asn Glu Ile 
    30185                 30190                 30195             


Ser Asn   Tyr Leu Val Asp Lys   Arg Glu Lys Lys Ser   Leu Arg Trp 
    30200                 30205                 30210             


Thr Arg   Val Asn Lys Asp Tyr   Val Val Tyr Asp Thr   Arg Leu Lys 
    30215                 30220                 30225             


Val Thr   Ser Leu Met Glu Gly   Cys Asp Tyr Gln Phe   Arg Val Thr 
    30230                 30235                 30240             


Ala Val   Asn Ala Ala Gly Asn   Ser Glu Pro Ser Glu   Ala Ser Asn 
    30245                 30250                 30255             


Phe Ile   Ser Cys Arg Glu Pro   Ser Tyr Thr Pro Gly   Pro Pro Ser 
    30260                 30265                 30270             


Ala Pro   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Ser Leu Ala 
    30275                 30280                 30285             


Trp Thr   Lys Pro Met Tyr Asp   Gly Gly Thr Asp Ile   Val Gly Tyr 
    30290                 30295                 30300             


Val Leu   Glu Met Gln Glu Lys   Asp Thr Asp Gln Trp   Tyr Arg Val 
    30305                 30310                 30315             


His Thr   Asn Ala Thr Ile Arg   Asn Thr Glu Phe Thr   Val Pro Asp 
    30320                 30325                 30330             


Leu Lys   Met Gly Gln Lys Tyr   Ser Phe Arg Val Ala   Ala Val Asn 
    30335                 30340                 30345             


Val Lys   Gly Met Ser Glu Tyr   Ser Glu Ser Ile Ala   Glu Ile Glu 
    30350                 30355                 30360             


Pro Val   Glu Arg Ile Glu Ile   Pro Asp Leu Glu Leu   Ala Asp Asp 
    30365                 30370                 30375             


Leu Lys   Lys Thr Val Thr Ile   Arg Ala Gly Ala Ser   Leu Arg Leu 
    30380                 30385                 30390             


Met Val   Ser Val Ser Gly Arg   Pro Pro Pro Val Ile   Thr Trp Ser 
    30395                 30400                 30405             


Lys Gln   Gly Ile Asp Leu Ala   Ser Arg Ala Ile Ile   Asp Thr Thr 
    30410                 30415                 30420             


Glu Ser   Tyr Ser Leu Leu Ile   Val Asp Lys Val Asn   Arg Tyr Asp 
    30425                 30430                 30435             


Ala Gly   Lys Tyr Thr Ile Glu   Ala Glu Asn Gln Ser   Gly Lys Lys 
    30440                 30445                 30450             


Ser Ala   Thr Val Leu Val Lys   Val Tyr Asp Thr Pro   Gly Pro Cys 
    30455                 30460                 30465             


Pro Ser   Val Lys Val Lys Glu   Val Ser Arg Asp Ser   Val Thr Ile 
    30470                 30475                 30480             


Thr Trp   Glu Ile Pro Thr Ile   Asp Gly Gly Ala Pro   Val Asn Asn 
    30485                 30490                 30495             


Tyr Ile   Val Glu Lys Arg Glu   Ala Ala Met Arg Ala   Phe Lys Thr 
    30500                 30505                 30510             


Val Thr   Thr Lys Cys Ser Lys   Thr Leu Tyr Arg Ile   Ser Gly Leu 
    30515                 30520                 30525             


Val Glu   Gly Thr Met Tyr Tyr   Phe Arg Val Leu Pro   Glu Asn Ile 
    30530                 30535                 30540             


Tyr Gly   Ile Gly Glu Pro Cys   Glu Thr Ser Asp Ala   Val Leu Val 
    30545                 30550                 30555             


Ser Glu   Val Pro Leu Val Pro   Ala Lys Leu Glu Val   Val Asp Val 
    30560                 30565                 30570             


Thr Lys   Ser Thr Val Thr Leu   Ala Trp Glu Lys Pro   Leu Tyr Asp 
    30575                 30580                 30585             


Gly Gly   Ser Arg Leu Thr Gly   Tyr Val Leu Glu Ala   Cys Lys Ala 
    30590                 30595                 30600             


Gly Thr   Glu Arg Trp Met Lys   Val Val Thr Leu Lys   Pro Thr Val 
    30605                 30610                 30615             


Leu Glu   His Thr Val Thr Ser   Leu Asn Glu Gly Glu   Gln Tyr Leu 
    30620                 30625                 30630             


Phe Arg   Ile Arg Ala Gln Asn   Glu Lys Gly Val Ser   Glu Pro Arg 
    30635                 30640                 30645             


Glu Thr   Val Thr Ala Val Thr   Val Gln Asp Leu Arg   Val Leu Pro 
    30650                 30655                 30660             


Thr Ile   Asp Leu Ser Thr Met   Pro Gln Lys Thr Ile   His Val Pro 
    30665                 30670                 30675             


Ala Gly   Arg Pro Val Glu Leu   Val Ile Pro Ile Ala   Gly Arg Pro 
    30680                 30685                 30690             


Pro Pro   Ala Ala Ser Trp Phe   Phe Ala Gly Ser Lys   Leu Arg Glu 
    30695                 30700                 30705             


Ser Glu   Arg Val Thr Val Glu   Thr His Thr Lys Val   Ala Lys Leu 
    30710                 30715                 30720             


Thr Ile   Arg Glu Thr Thr Ile   Arg Asp Thr Gly Glu   Tyr Thr Leu 
    30725                 30730                 30735             


Glu Leu   Lys Asn Val Thr Gly   Thr Thr Ser Glu Thr   Ile Lys Val 
    30740                 30745                 30750             


Ile Ile   Leu Asp Lys Pro Gly   Pro Pro Thr Gly Pro   Ile Lys Ile 
    30755                 30760                 30765             


Asp Glu   Ile Asp Ala Thr Ser   Ile Thr Ile Ser Trp   Glu Pro Pro 
    30770                 30775                 30780             


Glu Leu   Asp Gly Gly Ala Pro   Leu Ser Gly Tyr Val   Val Glu Gln 
    30785                 30790                 30795             


Arg Asp   Ala His Arg Pro Gly   Trp Leu Pro Val Ser   Glu Ser Val 
    30800                 30805                 30810             


Thr Arg   Ser Thr Phe Lys Phe   Thr Arg Leu Thr Glu   Gly Asn Glu 
    30815                 30820                 30825             


Tyr Val   Phe Arg Val Ala Ala   Thr Asn Arg Phe Gly   Ile Gly Ser 
    30830                 30835                 30840             


Tyr Leu   Gln Ser Glu Val Ile   Glu Cys Arg Ser Ser   Ile Arg Ile 
    30845                 30850                 30855             


Pro Gly   Pro Pro Glu Thr Leu   Gln Ile Phe Asp Val   Ser Arg Asp 
    30860                 30865                 30870             


Gly Met   Thr Leu Thr Trp Tyr   Pro Pro Glu Asp Asp   Gly Gly Ser 
    30875                 30880                 30885             


Gln Val   Thr Gly Tyr Ile Val   Glu Arg Lys Glu Val   Arg Ala Asp 
    30890                 30895                 30900             


Arg Trp   Val Arg Val Asn Lys   Val Pro Val Thr Met   Thr Arg Tyr 
    30905                 30910                 30915             


Arg Ser   Thr Gly Leu Thr Glu   Gly Leu Glu Tyr Glu   His Arg Val 
    30920                 30925                 30930             


Thr Ala   Ile Asn Ala Arg Gly   Ser Gly Lys Pro Ser   Arg Pro Ser 
    30935                 30940                 30945             


Lys Pro   Ile Val Ala Met Asp   Pro Ile Ala Pro Pro   Gly Lys Pro 
    30950                 30955                 30960             


Gln Asn   Pro Arg Val Thr Asp   Thr Thr Arg Thr Ser   Val Ser Leu 
    30965                 30970                 30975             


Ala Trp   Ser Val Pro Glu Asp   Glu Gly Gly Ser Lys   Val Thr Gly 
    30980                 30985                 30990             


Tyr Leu   Ile Glu Met Gln Lys   Val Asp Gln His Glu   Trp Thr Lys 
    30995                 31000                 31005             


Cys Asn   Thr Thr Pro Thr Lys   Ile Arg Glu Tyr Thr   Leu Thr His 
    31010                 31015                 31020             


Leu Pro   Gln Gly Ala Glu Tyr   Arg Phe Arg Val Leu   Ala Cys Asn 
    31025                 31030                 31035             


Ala Gly   Gly Pro Gly Glu Pro   Ala Glu Val Pro Gly   Thr Val Lys 
    31040                 31045                 31050             


Val Thr   Glu Met Leu Glu Tyr   Pro Asp Tyr Glu Leu   Asp Glu Arg 
    31055                 31060                 31065             


Tyr Gln   Glu Gly Ile Phe Val   Arg Gln Gly Gly Val   Ile Arg Leu 
    31070                 31075                 31080             


Thr Ile   Pro Ile Lys Gly Lys   Pro Phe Pro Ile Cys   Lys Trp Thr 
    31085                 31090                 31095             


Lys Glu   Gly Gln Asp Ile Ser   Lys Arg Ala Met Ile   Ala Thr Ser 
    31100                 31105                 31110             


Glu Thr   His Thr Glu Leu Val   Ile Lys Glu Ala Asp   Arg Gly Asp 
    31115                 31120                 31125             


Ser Gly   Thr Tyr Asp Leu Val   Leu Glu Asn Lys Cys   Gly Lys Lys 
    31130                 31135                 31140             


Ala Val   Tyr Ile Lys Val Arg   Val Ile Gly Ser Pro   Asn Ser Pro 
    31145                 31150                 31155             


Glu Gly   Pro Leu Glu Tyr Asp   Asp Ile Gln Val Arg   Ser Val Arg 
    31160                 31165                 31170             


Val Ser   Trp Arg Pro Pro Ala   Asp Asp Gly Gly Ala   Asp Ile Leu 
    31175                 31180                 31185             


Gly Tyr   Ile Leu Glu Arg Arg   Glu Val Pro Lys Ala   Ala Trp Tyr 
    31190                 31195                 31200             


Thr Ile   Asp Ser Arg Val Arg   Gly Thr Ser Leu Val   Val Lys Gly 
    31205                 31210                 31215             


Leu Lys   Glu Asn Val Glu Tyr   His Phe Arg Val Ser   Ala Glu Asn 
    31220                 31225                 31230             


Gln Phe   Gly Ile Ser Lys Pro   Leu Lys Ser Glu Glu   Pro Val Thr 
    31235                 31240                 31245             


Pro Lys   Thr Pro Leu Asn Pro   Pro Glu Pro Pro Ser   Asn Pro Pro 
    31250                 31255                 31260             


Glu Val   Leu Asp Val Thr Lys   Ser Ser Val Ser Leu   Ser Trp Ser 
    31265                 31270                 31275             


Arg Pro   Lys Asp Asp Gly Gly   Ser Arg Val Thr Gly   Tyr Tyr Ile 
    31280                 31285                 31290             


Glu Arg   Lys Glu Thr Ser Thr   Asp Lys Trp Val Arg   His Asn Lys 
    31295                 31300                 31305             


Thr Gln   Ile Thr Thr Thr Met   Tyr Thr Val Thr Gly   Leu Val Pro 
    31310                 31315                 31320             


Asp Ala   Glu Tyr Gln Phe Arg   Ile Ile Ala Gln Asn   Asp Val Gly 
    31325                 31330                 31335             


Leu Ser   Glu Thr Ser Pro Ala   Ser Glu Pro Val Val   Cys Lys Asp 
    31340                 31345                 31350             


Pro Phe   Asp Lys Pro Ser Gln   Pro Gly Glu Leu Glu   Ile Leu Ser 
    31355                 31360                 31365             


Ile Ser   Lys Asp Ser Val Thr   Leu Gln Trp Glu Lys   Pro Glu Cys 
    31370                 31375                 31380             


Asp Gly   Gly Lys Glu Ile Leu   Gly Tyr Trp Val Glu   Tyr Arg Gln 
    31385                 31390                 31395             


Ser Gly   Asp Ser Ala Trp Lys   Lys Ser Asn Lys Glu   Arg Ile Lys 
    31400                 31405                 31410             


Asp Lys   Gln Phe Thr Ile Gly   Gly Leu Leu Glu Ala   Thr Glu Tyr 
    31415                 31420                 31425             


Glu Phe   Arg Val Phe Ala Glu   Asn Glu Thr Gly Leu   Ser Arg Pro 
    31430                 31435                 31440             


Arg Arg   Thr Ala Met Ser Ile   Lys Thr Lys Leu Thr   Ser Gly Glu 
    31445                 31450                 31455             


Ala Pro   Gly Ile Arg Lys Glu   Met Lys Asp Val Thr   Thr Lys Leu 
    31460                 31465                 31470             


Gly Glu   Ala Ala Gln Leu Ser   Cys Gln Ile Val Gly   Arg Pro Leu 
    31475                 31480                 31485             


Pro Asp   Ile Lys Trp Tyr Arg   Phe Gly Lys Glu Leu   Ile Gln Ser 
    31490                 31495                 31500             


Arg Lys   Tyr Lys Met Ser Ser   Asp Gly Arg Thr His   Thr Leu Thr 
    31505                 31510                 31515             


Val Met   Thr Glu Glu Gln Glu   Asp Glu Gly Val Tyr   Thr Cys Ile 
    31520                 31525                 31530             


Ala Thr   Asn Glu Val Gly Glu   Val Glu Thr Ser Ser   Lys Leu Leu 
    31535                 31540                 31545             


Leu Gln   Ala Thr Pro Gln Phe   His Pro Gly Tyr Pro   Leu Lys Glu 
    31550                 31555                 31560             


Lys Tyr   Tyr Gly Ala Val Gly   Ser Thr Leu Arg Leu   His Val Met 
    31565                 31570                 31575             


Tyr Ile   Gly Arg Pro Val Pro   Ala Met Thr Trp Phe   His Gly Gln 
    31580                 31585                 31590             


Lys Leu   Leu Gln Asn Ser Glu   Asn Ile Thr Ile Glu   Asn Thr Glu 
    31595                 31600                 31605             


His Tyr   Thr His Leu Val Met   Lys Asn Val Gln Arg   Lys Thr His 
    31610                 31615                 31620             


Ala Gly   Lys Tyr Lys Val Gln   Leu Ser Asn Val Phe   Gly Thr Val 
    31625                 31630                 31635             


Asp Ala   Ile Leu Asp Val Glu   Ile Gln Asp Lys Pro   Asp Lys Pro 
    31640                 31645                 31650             


Thr Gly   Pro Ile Val Ile Glu   Ala Leu Leu Lys Asn   Ser Ala Val 
    31655                 31660                 31665             


Ile Ser   Trp Lys Pro Pro Ala   Asp Asp Gly Gly Ser   Trp Ile Thr 
    31670                 31675                 31680             


Asn Tyr   Val Val Glu Lys Cys   Glu Ala Lys Glu Gly   Ala Glu Trp 
    31685                 31690                 31695             


Gln Leu   Val Ser Ser Ala Ile   Ser Val Thr Thr Cys   Arg Ile Val 
    31700                 31705                 31710             


Asn Leu   Thr Glu Asn Ala Gly   Tyr Tyr Phe Arg Val   Ser Ala Gln 
    31715                 31720                 31725             


Asn Thr   Phe Gly Ile Ser Asp   Pro Leu Glu Val Ser   Ser Val Val 
    31730                 31735                 31740             


Ile Ile   Lys Ser Pro Phe Glu   Lys Pro Gly Ala Pro   Gly Lys Pro 
    31745                 31750                 31755             


Thr Ile   Thr Ala Val Thr Lys   Asp Ser Cys Val Val   Ala Trp Lys 
    31760                 31765                 31770             


Pro Pro   Ala Ser Asp Gly Gly   Ala Lys Ile Arg Asn   Tyr Tyr Leu 
    31775                 31780                 31785             


Glu Lys   Arg Glu Lys Lys Gln   Asn Lys Trp Ile Ser   Val Thr Thr 
    31790                 31795                 31800             


Glu Glu   Ile Arg Glu Thr Val   Phe Ser Val Lys Asn   Leu Ile Glu 
    31805                 31810                 31815             


Gly Leu   Glu Tyr Glu Phe Arg   Val Lys Cys Glu Asn   Leu Gly Gly 
    31820                 31825                 31830             


Glu Ser   Glu Trp Ser Glu Ile   Ser Glu Pro Ile Thr   Pro Lys Ser 
    31835                 31840                 31845             


Asp Val   Pro Ile Gln Ala Pro   His Phe Lys Glu Glu   Leu Arg Asn 
    31850                 31855                 31860             


Leu Asn   Val Arg Tyr Gln Ser   Asn Ala Thr Leu Val   Cys Lys Val 
    31865                 31870                 31875             


Thr Gly   His Pro Lys Pro Ile   Val Lys Trp Tyr Arg   Gln Gly Lys 
    31880                 31885                 31890             


Glu Ile   Ile Ala Asp Gly Leu   Lys Tyr Arg Ile Gln   Glu Phe Lys 
    31895                 31900                 31905             


Gly Gly   Tyr His Gln Leu Ile   Ile Ala Ser Val Thr   Asp Asp Asp 
    31910                 31915                 31920             


Ala Thr   Val Tyr Gln Val Arg   Ala Thr Asn Gln Gly   Gly Ser Val 
    31925                 31930                 31935             


Ser Gly   Thr Ala Ser Leu Glu   Val Glu Val Pro Ala   Lys Ile His 
    31940                 31945                 31950             


Leu Pro   Lys Thr Leu Glu Gly   Met Gly Ala Val His   Ala Leu Arg 
    31955                 31960                 31965             


Gly Glu   Val Val Ser Ile Lys   Ile Pro Phe Ser Gly   Lys Pro Asp 
    31970                 31975                 31980             


Pro Val   Ile Thr Trp Gln Lys   Gly Gln Asp Leu Ile   Asp Asn Asn 
    31985                 31990                 31995             


Gly His   Tyr Gln Val Ile Val   Thr Arg Ser Phe Thr   Ser Leu Val 
    32000                 32005                 32010             


Phe Pro   Asn Gly Val Glu Arg   Lys Asp Ala Gly Phe   Tyr Val Val 
    32015                 32020                 32025             


Cys Ala   Lys Asn Arg Phe Gly   Ile Asp Gln Lys Thr   Val Glu Leu 
    32030                 32035                 32040             


Asp Val   Ala Asp Val Pro Asp   Pro Pro Arg Gly Val   Lys Val Ser 
    32045                 32050                 32055             


Asp Val   Ser Arg Asp Ser Val   Asn Leu Thr Trp Thr   Glu Pro Ala 
    32060                 32065                 32070             


Ser Asp   Gly Gly Ser Lys Ile   Thr Asn Tyr Ile Val   Glu Lys Cys 
    32075                 32080                 32085             


Ala Thr   Thr Ala Glu Arg Trp   Leu Arg Val Gly Gln   Ala Arg Glu 
    32090                 32095                 32100             


Thr Arg   Tyr Thr Val Ile Asn   Leu Phe Gly Lys Thr   Ser Tyr Gln 
    32105                 32110                 32115             


Phe Arg   Val Ile Ala Glu Asn   Lys Phe Gly Leu Ser   Lys Pro Ser 
    32120                 32125                 32130             


Glu Pro   Ser Glu Pro Thr Ile   Thr Lys Glu Asp Lys   Thr Arg Ala 
    32135                 32140                 32145             


Met Asn   Tyr Asp Glu Glu Val   Asp Glu Thr Arg Glu   Val Ser Met 
    32150                 32155                 32160             


Thr Lys   Ala Ser His Ser Ser   Thr Lys Glu Leu Tyr   Glu Lys Tyr 
    32165                 32170                 32175             


Met Ile   Ala Glu Asp Leu Gly   Arg Gly Glu Phe Gly   Ile Val His 
    32180                 32185                 32190             


Arg Cys   Val Glu Thr Ser Ser   Lys Lys Thr Tyr Met   Ala Lys Phe 
    32195                 32200                 32205             


Val Lys   Val Lys Gly Thr Asp   Gln Val Leu Val Lys   Lys Glu Ile 
    32210                 32215                 32220             


Ser Ile   Leu Asn Ile Ala Arg   His Arg Asn Ile Leu   His Leu His 
    32225                 32230                 32235             


Glu Ser   Phe Glu Ser Met Glu   Glu Leu Val Met Ile   Phe Glu Phe 
    32240                 32245                 32250             


Ile Ser   Gly Leu Asp Ile Phe   Glu Arg Ile Asn Thr   Ser Ala Phe 
    32255                 32260                 32265             


Glu Leu   Asn Glu Arg Glu Ile   Val Ser Tyr Val His   Gln Val Cys 
    32270                 32275                 32280             


Glu Ala   Leu Gln Phe Leu His   Ser His Asn Ile Gly   His Phe Asp 
    32285                 32290                 32295             


Ile Arg   Pro Glu Asn Ile Ile   Tyr Gln Thr Arg Arg   Ser Ser Thr 
    32300                 32305                 32310             


Ile Lys   Ile Ile Glu Phe Gly   Gln Ala Arg Gln Leu   Lys Pro Gly 
    32315                 32320                 32325             


Asp Asn   Phe Arg Leu Leu Phe   Thr Ala Pro Glu Tyr   Tyr Ala Pro 
    32330                 32335                 32340             


Glu Val   His Gln His Asp Val   Val Ser Thr Ala Thr   Asp Met Trp 
    32345                 32350                 32355             


Ser Leu   Gly Thr Leu Val Tyr   Val Leu Leu Ser Gly   Ile Asn Pro 
    32360                 32365                 32370             


Phe Leu   Ala Glu Thr Asn Gln   Gln Ile Ile Glu Asn   Ile Met Asn 
    32375                 32380                 32385             


Ala Glu   Tyr Thr Phe Asp Glu   Glu Ala Phe Lys Glu   Ile Ser Ile 
    32390                 32395                 32400             


Glu Ala   Met Asp Phe Val Asp   Arg Leu Leu Val Lys   Glu Arg Lys 
    32405                 32410                 32415             


Ser Arg   Met Thr Ala Ser Glu   Ala Leu Gln His Pro   Trp Leu Lys 
    32420                 32425                 32430             


Gln Lys   Ile Glu Arg Val Ser   Thr Lys Val Ile Arg   Thr Leu Lys 
    32435                 32440                 32445             


His Arg   Arg Tyr Tyr His Thr   Leu Ile Lys Lys Asp   Leu Asn Met 
    32450                 32455                 32460             


Val Val   Ser Ala Ala Arg Ile   Ser Cys Gly Gly Ala   Ile Arg Ser 
    32465                 32470                 32475             


Gln Lys   Gly Val Ser Val Ala   Lys Val Lys Val Ala   Ser Ile Glu 
    32480                 32485                 32490             


Ile Gly   Pro Val Ser Gly Gln   Ile Met His Ala Val   Gly Glu Glu 
    32495                 32500                 32505             


Gly Gly   His Val Lys Tyr Val   Cys Lys Ile Glu Asn   Tyr Asp Gln 
    32510                 32515                 32520             


Ser Thr   Gln Val Thr Trp Tyr   Phe Gly Val Arg Gln   Leu Glu Asn 
    32525                 32530                 32535             


Ser Glu   Lys Tyr Glu Ile Thr   Tyr Glu Asp Gly Val   Ala Ile Leu 
    32540                 32545                 32550             


Tyr Val   Lys Asp Ile Thr Lys   Leu Asp Asp Gly Thr   Tyr Arg Cys 
    32555                 32560                 32565             


Lys Val   Val Asn Asp Tyr Gly   Glu Asp Ser Ser Tyr   Ala Glu Leu 
    32570                 32575                 32580             


Phe Val   Lys Gly Val Arg Glu   Val Tyr Asp Tyr Tyr   Cys Arg Arg 
    32585                 32590                 32595             


Thr Met   Lys Lys Ile Lys Arg   Arg Thr Asp Thr Met   Arg Leu Leu 
    32600                 32605                 32610             


Glu Arg   Pro Pro Glu Phe Thr   Leu Pro Leu Tyr Asn   Lys Thr Ala 
    32615                 32620                 32625             


Tyr Val   Gly Glu Asn Val Arg   Phe Gly Val Thr Ile   Thr Val His 
    32630                 32635                 32640             


Pro Glu   Pro His Val Thr Trp   Tyr Lys Ser Gly Gln   Lys Ile Lys 
    32645                 32650                 32655             


Pro Gly   Asp Asn Asp Lys Lys   Tyr Thr Phe Glu Ser   Asp Lys Gly 
    32660                 32665                 32670             


Leu Tyr   Gln Leu Thr Ile Asn   Ser Val Thr Thr Asp   Asp Asp Ala 
    32675                 32680                 32685             


Glu Tyr   Thr Val Val Ala Arg   Asn Lys Tyr Gly Glu   Asp Ser Cys 
    32690                 32695                 32700             


Lys Ala   Lys Leu Thr Val Thr   Leu His Pro Pro Pro   Thr Asp Ser 
    32705                 32710                 32715             


Thr Leu   Arg Pro Met Phe Lys   Arg Leu Leu Ala Asn   Ala Glu Cys 
    32720                 32725                 32730             


Gln Glu   Gly Gln Ser Val Cys   Phe Glu Ile Arg Val   Ser Gly Ile 
    32735                 32740                 32745             


Pro Pro   Pro Thr Leu Lys Trp   Glu Lys Asp Gly Gln   Pro Leu Ser 
    32750                 32755                 32760             


Leu Gly   Pro Asn Ile Glu Ile   Ile His Glu Gly Leu   Asp Tyr Tyr 
    32765                 32770                 32775             


Ala Leu   His Ile Arg Asp Thr   Leu Pro Glu Asp Thr   Gly Tyr Tyr 
    32780                 32785                 32790             


Arg Val   Thr Ala Thr Asn Thr   Ala Gly Ser Thr Ser   Cys Gln Ala 
    32795                 32800                 32805             


His Leu   Gln Val Glu Arg Leu   Arg Tyr Lys Lys Gln   Glu Phe Lys 
    32810                 32815                 32820             


Ser Lys   Glu Glu His Glu Arg   His Val Gln Lys Gln   Ile Asp Lys 
    32825                 32830                 32835             


Thr Leu   Arg Met Ala Glu Ile   Leu Ser Gly Thr Glu   Ser Val Pro 
    32840                 32845                 32850             


Leu Thr   Gln Val Ala Lys Glu   Ala Leu Arg Glu Ala   Ala Val Leu 
    32855                 32860                 32865             


Tyr Lys   Pro Ala Val Ser Thr   Lys Thr Val Lys Gly   Glu Phe Arg 
    32870                 32875                 32880             


Leu Glu   Ile Glu Glu Lys Lys   Glu Glu Arg Lys Leu   Arg Met Pro 
    32885                 32890                 32895             


Tyr Asp   Val Pro Glu Pro Arg   Lys Tyr Lys Gln Thr   Thr Ile Glu 
    32900                 32905                 32910             


Glu Asp   Gln Arg Ile Lys Gln   Phe Val Pro Met Ser   Asp Met Lys 
    32915                 32920                 32925             


Trp Tyr   Lys Lys Ile Arg Asp   Gln Tyr Glu Met Pro   Gly Lys Leu 
    32930                 32935                 32940             


Asp Arg   Val Val Gln Lys Arg   Pro Lys Arg Ile Arg   Leu Ser Arg 
    32945                 32950                 32955             


Trp Glu   Gln Phe Tyr Val Met   Pro Leu Pro Arg Ile   Thr Asp Gln 
    32960                 32965                 32970             


Tyr Arg   Pro Lys Trp Arg Ile   Pro Lys Leu Ser Gln   Asp Asp Leu 
    32975                 32980                 32985             


Glu Ile   Val Arg Pro Ala Arg   Arg Arg Thr Pro Ser   Pro Asp Tyr 
    32990                 32995                 33000             


Asp Phe   Tyr Tyr Arg Pro Arg   Arg Arg Ser Leu Gly   Asp Ile Ser 
    33005                 33010                 33015             


Asp Glu   Glu Leu Leu Leu Pro   Ile Asp Asp Tyr Leu   Ala Met Lys 
    33020                 33025                 33030             


Arg Thr   Glu Glu Glu Arg Leu   Arg Leu Glu Glu Glu   Leu Glu Leu 
    33035                 33040                 33045             


Gly Phe   Ser Ala Ser Pro Pro   Ser Arg Ser Pro Pro   His Phe Glu 
    33050                 33055                 33060             


Leu Ser   Ser Leu Arg Tyr Ser   Ser Pro Gln Ala His   Val Lys Val 
    33065                 33070                 33075             


Glu Glu   Thr Arg Lys Asp Phe   Arg Tyr Ser Thr Tyr   His Ile Pro 
    33080                 33085                 33090             


Thr Lys   Ala Glu Ala Ser Thr   Ser Tyr Ala Glu Leu   Arg Glu Arg 
    33095                 33100                 33105             


His Ala   Gln Ala Ala Tyr Arg   Gln Pro Lys Gln Arg   Gln Arg Ile 
    33110                 33115                 33120             


Met Ala   Glu Arg Glu Asp Glu   Glu Leu Leu Arg Pro   Val Thr Thr 
    33125                 33130                 33135             


Thr Gln   His Leu Ser Glu Tyr   Lys Ser Glu Leu Asp   Phe Met Ser 
    33140                 33145                 33150             


Lys Glu   Glu Lys Ser Arg Lys   Lys Ser Arg Arg Gln   Arg Glu Val 
    33155                 33160                 33165             


Thr Glu   Ile Thr Glu Ile Glu   Glu Glu Tyr Glu Ile   Ser Lys His 
    33170                 33175                 33180             


Ala Gln   Arg Glu Ser Ser Ser   Ser Ala Ser Arg Leu   Leu Arg Arg 
    33185                 33190                 33195             


Arg Arg   Ser Leu Ser Pro Thr   Tyr Ile Glu Leu Met   Arg Pro Val 
    33200                 33205                 33210             


Ser Glu   Leu Ile Arg Ser Arg   Pro Gln Pro Ala Glu   Glu Tyr Glu 
    33215                 33220                 33225             


Asp Asp   Thr Glu Arg Arg Ser   Pro Thr Pro Glu Arg   Thr Arg Pro 
    33230                 33235                 33240             


Arg Ser   Pro Ser Pro Val Ser   Ser Glu Arg Ser Leu   Ser Arg Phe 
    33245                 33250                 33255             


Glu Arg   Ser Ala Arg Phe Asp   Ile Phe Ser Arg Tyr   Glu Ser Met 
    33260                 33265                 33270             


Lys Ala   Ala Leu Lys Thr Gln   Lys Thr Ser Glu Arg   Lys Tyr Glu 
    33275                 33280                 33285             


Val Leu   Ser Gln Gln Pro Phe   Thr Leu Asp His Ala   Pro Arg Ile 
    33290                 33295                 33300             


Thr Leu   Arg Met Arg Ser His   Arg Val Pro Cys Gly   Gln Asn Thr 
    33305                 33310                 33315             


Arg Phe   Ile Leu Asn Val Gln   Ser Lys Pro Thr Ala   Glu Val Lys 
    33320                 33325                 33330             


Trp Tyr   His Asn Gly Val Glu   Leu Gln Glu Ser Ser   Lys Ile His 
    33335                 33340                 33345             


Tyr Thr   Asn Thr Ser Gly Val   Leu Thr Leu Glu Ile   Leu Asp Cys 
    33350                 33355                 33360             


His Thr   Asp Asp Ser Gly Thr   Tyr Arg Ala Val Cys   Thr Asn Tyr 
    33365                 33370                 33375             


Lys Gly   Glu Ala Ser Asp Tyr   Ala Thr Leu Asp Val   Thr Gly Gly 
    33380                 33385                 33390             


Asp Tyr   Thr Thr Tyr Ala Ser   Gln Arg Arg Asp Glu   Glu Val Pro 
    33395                 33400                 33405             


Arg Ser   Val Phe Pro Glu Leu   Thr Arg Thr Glu Ala   Tyr Ala Val 
    33410                 33415                 33420             


Ser Ser   Phe Lys Lys Thr Ser   Glu Met Glu Ala Ser   Ser Ser Val 
    33425                 33430                 33435             


Arg Glu   Val Lys Ser Gln Met   Thr Glu Thr Arg Glu   Ser Leu Ser 
    33440                 33445                 33450             


Ser Tyr   Glu His Ser Ala Ser   Ala Glu Met Lys Ser   Ala Ala Leu 
    33455                 33460                 33465             


Glu Glu   Lys Ser Leu Glu Glu   Lys Ser Thr Thr Arg   Lys Ile Lys 
    33470                 33475                 33480             


Thr Thr   Leu Ala Ala Arg Ile   Leu Thr Lys Pro Arg   Ser Met Thr 
    33485                 33490                 33495             


Val Tyr   Glu Gly Glu Ser Ala   Arg Phe Ser Cys Asp   Thr Asp Gly 
    33500                 33505                 33510             


Glu Pro   Val Pro Thr Val Thr   Trp Leu Arg Lys Gly   Gln Val Leu 
    33515                 33520                 33525             


Ser Thr   Ser Ala Arg His Gln   Val Thr Thr Thr Lys   Tyr Lys Ser 
    33530                 33535                 33540             


Thr Phe   Glu Ile Ser Ser Val   Gln Ala Ser Asp Glu   Gly Asn Tyr 
    33545                 33550                 33555             


Ser Val   Val Val Glu Asn Ser   Glu Gly Lys Gln Glu   Ala Glu Phe 
    33560                 33565                 33570             


Thr Leu   Thr Ile Gln Lys Ala   Arg Val Thr Glu Lys   Ala Val Thr 
    33575                 33580                 33585             


Ser Pro   Pro Arg Val Lys Ser   Pro Glu Pro Arg Val   Lys Ser Pro 
    33590                 33595                 33600             


Glu Ala   Val Lys Ser Pro Lys   Arg Val Lys Ser Pro   Glu Pro Ser 
    33605                 33610                 33615             


His Pro   Lys Ala Val Ser Pro   Thr Glu Thr Lys Pro   Thr Pro Thr 
    33620                 33625                 33630             


Glu Lys   Val Gln His Leu Pro   Val Ser Ala Pro Pro   Lys Ile Thr 
    33635                 33640                 33645             


Gln Phe   Leu Lys Ala Glu Ala   Ser Lys Glu Ile Ala   Lys Leu Thr 
    33650                 33655                 33660             


Cys Val   Val Glu Ser Ser Val   Leu Arg Ala Lys Glu   Val Thr Trp 
    33665                 33670                 33675             


Tyr Lys   Asp Gly Lys Lys Leu   Lys Glu Asn Gly His   Phe Gln Phe 
    33680                 33685                 33690             


His Tyr   Ser Ala Asp Gly Thr   Tyr Glu Leu Lys Ile   Asn Asn Leu 
    33695                 33700                 33705             


Thr Glu   Ser Asp Gln Gly Glu   Tyr Val Cys Glu Ile   Ser Gly Glu 
    33710                 33715                 33720             


Gly Gly   Thr Ser Lys Thr Asn   Leu Gln Phe Met Gly   Gln Ala Phe 
    33725                 33730                 33735             


Lys Ser   Ile His Glu Lys Val   Ser Lys Ile Ser Glu   Thr Lys Lys 
    33740                 33745                 33750             


Ser Asp   Gln Lys Thr Thr Glu   Ser Thr Val Thr Arg   Lys Thr Glu 
    33755                 33760                 33765             


Pro Lys   Ala Pro Glu Pro Ile   Ser Ser Lys Pro Val   Ile Val Thr 
    33770                 33775                 33780             


Gly Leu   Gln Asp Thr Thr Val   Ser Ser Asp Ser Val   Ala Lys Phe 
    33785                 33790                 33795             


Ala Val   Lys Ala Thr Gly Glu   Pro Arg Pro Thr Ala   Ile Trp Thr 
    33800                 33805                 33810             


Lys Asp   Gly Lys Ala Ile Thr   Gln Gly Gly Lys Tyr   Lys Leu Ser 
    33815                 33820                 33825             


Glu Asp   Lys Gly Gly Phe Phe   Leu Glu Ile His Lys   Thr Asp Thr 
    33830                 33835                 33840             


Ser Asp   Ser Gly Leu Tyr Thr   Cys Thr Val Lys Asn   Ser Ala Gly 
    33845                 33850                 33855             


Ser Val   Ser Ser Ser Cys Lys   Leu Thr Ile Lys Ala   Ile Lys Asp 
    33860                 33865                 33870             


Thr Glu   Ala Gln Lys Val Ser   Thr Gln Lys Thr Ser   Glu Ile Thr 
    33875                 33880                 33885             


Pro Gln   Lys Lys Ala Val Val   Gln Glu Glu Ile Ser   Gln Lys Ala 
    33890                 33895                 33900             


Leu Arg   Ser Glu Glu Ile Lys   Met Ser Glu Ala Lys   Ser Gln Glu 
    33905                 33910                 33915             


Lys Leu   Ala Leu Lys Glu Glu   Ala Ser Lys Val Leu   Ile Ser Glu 
    33920                 33925                 33930             


Glu Val   Lys Lys Ser Ala Ala   Thr Ser Leu Glu Lys   Ser Ile Val 
    33935                 33940                 33945             


His Glu   Glu Ile Thr Lys Thr   Ser Gln Ala Ser Glu   Glu Val Arg 
    33950                 33955                 33960             


Thr His   Ala Glu Ile Lys Ala   Phe Ser Thr Gln Met   Ser Ile Asn 
    33965                 33970                 33975             


Glu Gly   Gln Arg Leu Val Leu   Lys Ala Asn Ile Ala   Gly Ala Thr 
    33980                 33985                 33990             


Asp Val   Lys Trp Val Leu Asn   Gly Val Glu Leu Thr   Asn Ser Glu 
    33995                 34000                 34005             


Glu Tyr   Arg Tyr Gly Val Ser   Gly Ser Asp Gln Thr   Leu Thr Ile 
    34010                 34015                 34020             


Lys Gln   Ala Ser His Arg Asp   Glu Gly Ile Leu Thr   Cys Ile Ser 
    34025                 34030                 34035             


Lys Thr   Lys Glu Gly Ile Val   Lys Cys Gln Tyr Asp   Leu Thr Leu 
    34040                 34045                 34050             


Ser Lys   Glu Leu Ser Asp Ala   Pro Ala Phe Ile Ser   Gln Pro Arg 
    34055                 34060                 34065             


Ser Gln   Asn Ile Asn Glu Gly   Gln Asn Val Leu Phe   Thr Cys Glu 
    34070                 34075                 34080             


Ile Ser   Gly Glu Pro Ser Pro   Glu Ile Glu Trp Phe   Lys Asn Asn 
    34085                 34090                 34095             


Leu Pro   Ile Ser Ile Ser Ser   Asn Val Ser Ile Ser   Arg Ser Arg 
    34100                 34105                 34110             


Asn Val   Tyr Ser Leu Glu Ile   Arg Asn Ala Ser Val   Ser Asp Ser 
    34115                 34120                 34125             


Gly Lys   Tyr Thr Ile Lys Ala   Lys Asn Phe Arg Gly   Gln Cys Ser 
    34130                 34135                 34140             


Ala Thr   Ala Ser Leu Met Val   Leu Pro Leu Val Glu   Glu Pro Ser 
    34145                 34150                 34155             


Arg Glu   Val Val Leu Arg Thr   Ser Gly Asp Thr Ser   Leu Gln Gly 
    34160                 34165                 34170             


Ser Phe   Ser Ser Gln Ser Val   Gln Met Ser Ala Ser   Lys Gln Glu 
    34175                 34180                 34185             


Ala Ser   Phe Ser Ser Phe Ser   Ser Ser Ser Ala Ser   Ser Met Thr 
    34190                 34195                 34200             


Glu Met   Lys Phe Ala Ser Met   Ser Ala Gln Ser Met   Ser Ser Met 
    34205                 34210                 34215             


Gln Glu   Ser Phe Val Glu Met   Ser Ser Ser Ser Phe   Met Gly Ile 
    34220                 34225                 34230             


Ser Asn   Met Thr Gln Leu Glu   Ser Ser Thr Ser Lys   Met Leu Lys 
    34235                 34240                 34245             


Ala Gly   Ile Arg Gly Ile Pro   Pro Lys Ile Glu Ala   Leu Pro Ser 
    34250                 34255                 34260             


Asp Ile   Ser Ile Asp Glu Gly   Lys Val Leu Thr Val   Ala Cys Ala 
    34265                 34270                 34275             


Phe Thr   Gly Glu Pro Thr Pro   Glu Val Thr Trp Ser   Cys Gly Gly 
    34280                 34285                 34290             


Arg Lys   Ile His Ser Gln Glu   Gln Gly Arg Phe His   Ile Glu Asn 
    34295                 34300                 34305             


Thr Asp   Asp Leu Thr Thr Leu   Ile Ile Met Asp Val   Gln Lys Gln 
    34310                 34315                 34320             


Asp Gly   Gly Leu Tyr Thr Leu   Ser Leu Gly Asn Glu   Phe Gly Ser 
    34325                 34330                 34335             


Asp Ser   Ala Thr Val Asn Ile   His Ile Arg Ser Ile   
    34340                 34345                 34350 


<210> 236
<211> 4646
<212> PRT
<213> Homo sapiens

<400> 236
Met Ser Glu Pro Gly Gly Gly Gly Gly Glu Asp Gly Ser Ala Gly Leu 
1               5                   10                  15      


Glu Val Ser Ala Val Gln Asn Val Ala Asp Val Ser Val Leu Gln Lys 
            20                  25                  30          


His Leu Arg Lys Leu Val Pro Leu Leu Leu Glu Asp Gly Gly Glu Ala 
        35                  40                  45              


Pro Ala Ala Leu Glu Ala Ala Leu Glu Glu Lys Ser Ala Leu Glu Gln 
    50                  55                  60                  


Met Arg Lys Phe Leu Ser Asp Pro Gln Val His Thr Val Leu Val Glu 
65                  70                  75                  80  


Arg Ser Thr Leu Lys Glu Asp Val Gly Asp Glu Gly Glu Glu Glu Lys 
                85                  90                  95      


Glu Phe Ile Ser Tyr Asn Ile Asn Ile Asp Ile His Tyr Gly Val Lys 
            100                 105                 110         


Ser Asn Ser Leu Ala Phe Ile Lys Arg Thr Pro Val Ile Asp Ala Asp 
        115                 120                 125             


Lys Pro Val Ser Ser Gln Leu Arg Val Leu Thr Leu Ser Glu Asp Ser 
    130                 135                 140                 


Pro Tyr Glu Thr Leu His Ser Phe Ile Ser Asn Ala Val Ala Pro Phe 
145                 150                 155                 160 


Phe Lys Ser Tyr Ile Arg Glu Ser Gly Lys Ala Asp Arg Asp Gly Asp 
                165                 170                 175     


Lys Met Ala Pro Ser Val Glu Lys Lys Ile Ala Glu Leu Glu Met Gly 
            180                 185                 190         


Leu Leu His Leu Gln Gln Asn Ile Glu Ile Pro Glu Ile Ser Leu Pro 
        195                 200                 205             


Ile His Pro Met Ile Thr Asn Val Ala Lys Gln Cys Tyr Glu Arg Gly 
    210                 215                 220                 


Glu Lys Pro Lys Val Thr Asp Phe Gly Asp Lys Val Glu Asp Pro Thr 
225                 230                 235                 240 


Phe Leu Asn Gln Leu Gln Ser Gly Val Asn Arg Trp Ile Arg Glu Ile 
                245                 250                 255     


Gln Lys Val Thr Lys Leu Asp Arg Asp Pro Ala Ser Gly Thr Ala Leu 
            260                 265                 270         


Gln Glu Ile Ser Phe Trp Leu Asn Leu Glu Arg Ala Leu Tyr Arg Ile 
        275                 280                 285             


Gln Glu Lys Arg Glu Ser Pro Glu Val Leu Leu Thr Leu Asp Ile Leu 
    290                 295                 300                 


Lys His Gly Lys Arg Phe His Ala Thr Val Ser Phe Asp Thr Asp Thr 
305                 310                 315                 320 


Gly Leu Lys Gln Ala Leu Glu Thr Val Asn Asp Tyr Asn Pro Leu Met 
                325                 330                 335     


Lys Asp Phe Pro Leu Asn Asp Leu Leu Ser Ala Thr Glu Leu Asp Lys 
            340                 345                 350         


Ile Arg Gln Ala Leu Val Ala Ile Phe Thr His Leu Arg Lys Ile Arg 
        355                 360                 365             


Asn Thr Lys Tyr Pro Ile Gln Arg Ala Leu Arg Leu Val Glu Ala Ile 
    370                 375                 380                 


Ser Arg Asp Leu Ser Ser Gln Leu Leu Lys Val Leu Gly Thr Arg Lys 
385                 390                 395                 400 


Leu Met His Val Ala Tyr Glu Glu Phe Glu Lys Val Met Val Ala Cys 
                405                 410                 415     


Phe Glu Val Phe Gln Thr Trp Asp Asp Glu Tyr Glu Lys Leu Gln Val 
            420                 425                 430         


Leu Leu Arg Asp Ile Val Lys Arg Lys Arg Glu Glu Asn Leu Lys Met 
        435                 440                 445             


Val Trp Arg Ile Asn Pro Ala His Arg Lys Leu Gln Ala Arg Leu Asp 
    450                 455                 460                 


Gln Met Arg Lys Phe Arg Arg Gln His Glu Gln Leu Arg Ala Val Ile 
465                 470                 475                 480 


Val Arg Val Leu Arg Pro Gln Val Thr Ala Val Ala Gln Gln Asn Gln 
                485                 490                 495     


Gly Glu Val Pro Glu Pro Gln Asp Met Lys Val Ala Glu Val Leu Phe 
            500                 505                 510         


Asp Ala Ala Asp Ala Asn Ala Ile Glu Glu Val Asn Leu Ala Tyr Glu 
        515                 520                 525             


Asn Val Lys Glu Val Asp Gly Leu Asp Val Ser Lys Glu Gly Thr Glu 
    530                 535                 540                 


Ala Trp Glu Ala Ala Met Lys Arg Tyr Asp Glu Arg Ile Asp Arg Val 
545                 550                 555                 560 


Glu Thr Arg Ile Thr Ala Arg Leu Arg Asp Gln Leu Gly Thr Ala Lys 
                565                 570                 575     


Asn Ala Asn Glu Met Phe Arg Ile Phe Ser Arg Phe Asn Ala Leu Phe 
            580                 585                 590         


Val Arg Pro His Ile Arg Gly Ala Ile Arg Glu Tyr Gln Thr Gln Leu 
        595                 600                 605             


Ile Gln Arg Val Lys Asp Asp Ile Glu Ser Leu His Asp Lys Phe Lys 
    610                 615                 620                 


Val Gln Tyr Pro Gln Ser Gln Ala Cys Lys Met Ser His Val Arg Asp 
625                 630                 635                 640 


Leu Pro Pro Val Ser Gly Ser Ile Ile Trp Ala Lys Gln Ile Asp Arg 
                645                 650                 655     


Gln Leu Thr Ala Tyr Met Lys Arg Val Glu Asp Val Leu Gly Lys Gly 
            660                 665                 670         


Trp Glu Asn His Val Glu Gly Gln Lys Leu Lys Gln Asp Gly Asp Ser 
        675                 680                 685             


Phe Arg Met Lys Leu Asn Thr Gln Glu Ile Phe Asp Asp Trp Ala Arg 
    690                 695                 700                 


Lys Val Gln Gln Arg Asn Leu Gly Val Ser Gly Arg Ile Phe Thr Ile 
705                 710                 715                 720 


Glu Ser Thr Arg Val Arg Gly Arg Thr Gly Asn Val Leu Lys Leu Lys 
                725                 730                 735     


Val Asn Phe Leu Pro Glu Ile Ile Thr Leu Ser Lys Glu Val Arg Asn 
            740                 745                 750         


Leu Lys Trp Leu Gly Phe Arg Val Pro Leu Ala Ile Val Asn Lys Ala 
        755                 760                 765             


His Gln Ala Asn Gln Leu Tyr Pro Phe Ala Ile Ser Leu Ile Glu Ser 
    770                 775                 780                 


Val Arg Thr Tyr Glu Arg Thr Cys Glu Lys Val Glu Glu Arg Asn Thr 
785                 790                 795                 800 


Ile Ser Leu Leu Val Ala Gly Leu Lys Lys Glu Val Gln Ala Leu Ile 
                805                 810                 815     


Ala Glu Gly Ile Ala Leu Val Trp Glu Ser Tyr Lys Leu Asp Pro Tyr 
            820                 825                 830         


Val Gln Arg Leu Ala Glu Thr Val Phe Asn Phe Gln Glu Lys Val Asp 
        835                 840                 845             


Asp Leu Leu Ile Ile Glu Glu Lys Ile Asp Leu Glu Val Arg Ser Leu 
    850                 855                 860                 


Glu Thr Cys Met Tyr Asp His Lys Thr Phe Ser Glu Ile Leu Asn Arg 
865                 870                 875                 880 


Val Gln Lys Ala Val Asp Asp Leu Asn Leu His Ser Tyr Ser Asn Leu 
                885                 890                 895     


Pro Ile Trp Val Asn Lys Leu Asp Met Glu Ile Glu Arg Ile Leu Gly 
            900                 905                 910         


Val Arg Leu Gln Ala Gly Leu Arg Ala Trp Thr Gln Val Leu Leu Gly 
        915                 920                 925             


Gln Ala Glu Asp Lys Ala Glu Val Asp Met Asp Thr Asp Ala Pro Gln 
    930                 935                 940                 


Val Ser His Lys Pro Gly Gly Glu Pro Lys Ile Lys Asn Val Val His 
945                 950                 955                 960 


Glu Leu Arg Ile Thr Asn Gln Val Ile Tyr Leu Asn Pro Pro Ile Glu 
                965                 970                 975     


Glu Cys Arg Tyr Lys Leu Tyr Gln Glu Met Phe Ala Trp Lys Met Val 
            980                 985                 990         


Val Leu Ser Leu Pro Arg Ile Gln  Ser Gln Arg Tyr Gln  Val Gly Val 
        995                 1000                 1005             


His Tyr  Glu Leu Thr Glu Glu  Glu Lys Phe Tyr Arg  Asn Ala Leu 
    1010                 1015                 1020             


Thr Arg  Met Pro Asp Gly Pro  Val Ala Leu Glu Glu  Ser Tyr Ser 
    1025                 1030                 1035             


Ala Val  Met Gly Ile Val Ser  Glu Val Glu Gln Tyr  Val Lys Val 
    1040                 1045                 1050             


Trp Leu  Gln Tyr Gln Cys Leu  Trp Asp Met Gln Ala  Glu Asn Ile 
    1055                 1060                 1065             


Tyr Asn  Arg Leu Gly Glu Asp  Leu Asn Lys Trp Gln  Ala Leu Leu 
    1070                 1075                 1080             


Val Gln  Ile Arg Lys Ala Arg  Gly Thr Phe Asp Asn  Ala Glu Thr 
    1085                 1090                 1095             


Lys Lys  Glu Phe Gly Pro Val  Val Ile Asp Tyr Gly  Lys Val Gln 
    1100                 1105                 1110             


Ser Lys  Val Asn Leu Lys Tyr  Asp Ser Trp His Lys  Glu Val Leu 
    1115                 1120                 1125             


Ser Lys  Phe Gly Gln Met Leu  Gly Ser Asn Met Thr  Glu Phe His 
    1130                 1135                 1140             


Ser Gln  Ile Ser Lys Ser Arg  Gln Glu Leu Glu Gln  His Ser Val 
    1145                 1150                 1155             


Asp Thr  Ala Ser Thr Ser Asp  Ala Val Thr Phe Ile  Thr Tyr Val 
    1160                 1165                 1170             


Gln Ser  Leu Lys Arg Lys Ile  Lys Gln Phe Glu Lys  Gln Val Glu 
    1175                 1180                 1185             


Leu Tyr  Arg Asn Gly Gln Arg  Leu Leu Glu Lys Gln  Arg Phe Gln 
    1190                 1195                 1200             


Phe Pro  Pro Ser Trp Leu Tyr  Ile Asp Asn Ile Glu  Gly Glu Trp 
    1205                 1210                 1215             


Gly Ala  Phe Asn Asp Ile Met  Arg Arg Lys Asp Ser  Ala Ile Gln 
    1220                 1225                 1230             


Gln Gln  Val Ala Asn Leu Gln  Met Lys Ile Val Gln  Glu Asp Arg 
    1235                 1240                 1245             


Ala Val  Glu Ser Arg Thr Thr  Asp Leu Leu Thr Asp  Trp Glu Lys 
    1250                 1255                 1260             


Thr Lys  Pro Val Thr Gly Asn  Leu Arg Pro Glu Glu  Ala Leu Gln 
    1265                 1270                 1275             


Ala Leu  Thr Ile Tyr Glu Gly  Lys Phe Gly Arg Leu  Lys Asp Asp 
    1280                 1285                 1290             


Arg Glu  Lys Cys Ala Lys Ala  Lys Glu Ala Leu Glu  Leu Thr Asp 
    1295                 1300                 1305             


Thr Gly  Leu Leu Ser Gly Ser  Glu Glu Arg Val Gln  Val Ala Leu 
    1310                 1315                 1320             


Glu Glu  Leu Gln Asp Leu Lys  Gly Val Trp Ser Glu  Leu Ser Lys 
    1325                 1330                 1335             


Val Trp  Glu Gln Ile Asp Gln  Met Lys Glu Gln Pro  Trp Val Ser 
    1340                 1345                 1350             


Val Gln  Pro Arg Lys Leu Arg  Gln Asn Leu Asp Ala  Leu Leu Asn 
    1355                 1360                 1365             


Gln Leu  Lys Ser Phe Pro Ala  Arg Leu Arg Gln Tyr  Ala Ser Tyr 
    1370                 1375                 1380             


Glu Phe  Val Gln Arg Leu Leu  Lys Gly Tyr Met Lys  Ile Asn Met 
    1385                 1390                 1395             


Leu Val  Ile Glu Leu Lys Ser  Glu Ala Leu Lys Asp  Arg His Trp 
    1400                 1405                 1410             


Lys Gln  Leu Met Lys Arg Leu  His Val Asn Trp Val  Val Ser Glu 
    1415                 1420                 1425             


Leu Thr  Leu Gly Gln Ile Trp  Asp Val Asp Leu Gln  Lys Asn Glu 
    1430                 1435                 1440             


Ala Ile  Val Lys Asp Val Leu  Leu Val Ala Gln Gly  Glu Met Ala 
    1445                 1450                 1455             


Leu Glu  Glu Phe Leu Lys Gln  Ile Arg Glu Val Trp  Asn Thr Tyr 
    1460                 1465                 1470             


Glu Leu  Asp Leu Val Asn Tyr  Gln Asn Lys Cys Arg  Leu Ile Arg 
    1475                 1480                 1485             


Gly Trp  Asp Asp Leu Phe Asn  Lys Val Lys Glu His  Ile Asn Ser 
    1490                 1495                 1500             


Val Ser  Ala Met Lys Leu Ser  Pro Tyr Tyr Lys Val  Phe Glu Glu 
    1505                 1510                 1515             


Asp Ala  Leu Ser Trp Glu Asp  Lys Leu Asn Arg Ile  Met Ala Leu 
    1520                 1525                 1530             


Phe Asp  Val Trp Ile Asp Val  Gln Arg Arg Trp Val  Tyr Leu Glu 
    1535                 1540                 1545             


Gly Ile  Phe Thr Gly Ser Ala  Asp Ile Lys His Leu  Leu Pro Val 
    1550                 1555                 1560             


Glu Thr  Gln Arg Phe Gln Ser  Ile Ser Thr Glu Phe  Leu Ala Leu 
    1565                 1570                 1575             


Met Lys  Lys Val Ser Lys Ser  Pro Leu Val Met Asp  Val Leu Asn 
    1580                 1585                 1590             


Ile Gln  Gly Val Gln Arg Ser  Leu Glu Arg Leu Ala  Asp Leu Leu 
    1595                 1600                 1605             


Gly Lys  Ile Gln Lys Ala Leu  Gly Glu Tyr Leu Glu  Arg Glu Arg 
    1610                 1615                 1620             


Ser Ser  Phe Pro Arg Phe Tyr  Phe Val Gly Asp Glu  Asp Leu Leu 
    1625                 1630                 1635             


Glu Ile  Ile Gly Asn Ser Lys  Asn Val Ala Lys Leu  Gln Lys His 
    1640                 1645                 1650             


Phe Lys  Lys Met Phe Ala Gly  Val Ser Ser Ile Ile  Leu Asn Glu 
    1655                 1660                 1665             


Asp Asn  Ser Val Val Leu Gly  Ile Ser Ser Arg Glu  Gly Glu Glu 
    1670                 1675                 1680             


Val Met  Phe Lys Thr Pro Val  Ser Ile Thr Glu His  Pro Lys Ile 
    1685                 1690                 1695             


Asn Glu  Trp Leu Thr Leu Val  Glu Lys Glu Met Arg  Val Thr Leu 
    1700                 1705                 1710             


Ala Lys  Leu Leu Ala Glu Ser  Val Thr Glu Val Glu  Ile Phe Gly 
    1715                 1720                 1725             


Lys Ala  Thr Ser Ile Asp Pro  Asn Thr Tyr Ile Thr  Trp Ile Asp 
    1730                 1735                 1740             


Lys Tyr  Gln Ala Gln Leu Val  Val Leu Ser Ala Gln  Ile Ala Trp 
    1745                 1750                 1755             


Ser Glu  Asn Val Glu Thr Ala  Leu Ser Ser Met Gly  Gly Gly Gly 
    1760                 1765                 1770             


Asp Ala  Ala Pro Leu His Ser  Val Leu Ser Asn Val  Glu Val Thr 
    1775                 1780                 1785             


Leu Asn  Val Leu Ala Asp Ser  Val Leu Met Glu Gln  Pro Pro Leu 
    1790                 1795                 1800             


Arg Arg  Arg Lys Leu Glu His  Leu Ile Thr Glu Leu  Val His Gln 
    1805                 1810                 1815             


Arg Asp  Val Thr Arg Ser Leu  Ile Lys Ser Lys Ile  Asp Asn Ala 
    1820                 1825                 1830             


Lys Ser  Phe Glu Trp Leu Ser  Gln Met Arg Phe Tyr  Phe Asp Pro 
    1835                 1840                 1845             


Lys Gln  Thr Asp Val Leu Gln  Gln Leu Ser Ile Gln  Met Ala Asn 
    1850                 1855                 1860             


Ala Lys  Phe Asn Tyr Gly Phe  Glu Tyr Leu Gly Val  Gln Asp Lys 
    1865                 1870                 1875             


Leu Val  Gln Thr Pro Leu Thr  Asp Arg Cys Tyr Leu  Thr Met Thr 
    1880                 1885                 1890             


Gln Ala  Leu Glu Ala Arg Leu  Gly Gly Ser Pro Phe  Gly Pro Ala 
    1895                 1900                 1905             


Gly Thr  Gly Lys Thr Glu Ser  Val Lys Ala Leu Gly  His Gln Leu 
    1910                 1915                 1920             


Gly Arg  Phe Val Leu Val Phe  Asn Cys Asp Glu Thr  Phe Asp Phe 
    1925                 1930                 1935             


Gln Ala  Met Gly Arg Ile Phe  Val Gly Leu Cys Gln  Val Gly Ala 
    1940                 1945                 1950             


Trp Gly  Cys Phe Asp Glu Phe  Asn Arg Leu Glu Glu  Arg Met Leu 
    1955                 1960                 1965             


Ser Ala  Val Ser Gln Gln Val  Gln Cys Ile Gln Glu  Ala Leu Arg 
    1970                 1975                 1980             


Glu His  Ser Asn Pro Asn Tyr  Asp Lys Thr Ser Ala  Pro Ile Thr 
    1985                 1990                 1995             


Cys Glu  Leu Leu Asn Lys Gln  Val Lys Val Ser Pro  Asp Met Ala 
    2000                 2005                 2010             


Ile Phe  Ile Thr Met Asn Pro  Gly Tyr Ala Gly Arg  Ser Asn Leu 
    2015                 2020                 2025             


Pro Asp  Asn Leu Lys Lys Leu  Phe Arg Ser Leu Ala  Met Thr Lys 
    2030                 2035                 2040             


Pro Asp  Arg Gln Leu Ile Ala  Gln Val Met Leu Tyr  Ser Gln Gly 
    2045                 2050                 2055             


Phe Arg  Thr Ala Glu Val Leu  Ala Asn Lys Ile Val  Pro Phe Phe 
    2060                 2065                 2070             


Lys Leu  Cys Asp Glu Gln Leu  Ser Ser Gln Ser His  Tyr Asp Phe 
    2075                 2080                 2085             


Gly Leu  Arg Ala Leu Lys Ser  Val Leu Val Ser Ala  Gly Asn Val 
    2090                 2095                 2100             


Lys Arg  Glu Arg Ile Gln Lys  Ile Lys Arg Glu Lys  Glu Glu Arg 
    2105                 2110                 2115             


Gly Glu  Ala Val Asp Glu Gly  Glu Ile Ala Glu Asn  Leu Pro Glu 
    2120                 2125                 2130             


Gln Glu  Ile Leu Ile Gln Ser  Val Cys Glu Thr Met  Val Pro Lys 
    2135                 2140                 2145             


Leu Val  Ala Glu Asp Ile Pro  Leu Leu Phe Ser Leu  Leu Ser Asp 
    2150                 2155                 2160             


Val Phe  Pro Gly Val Gln Tyr  His Arg Gly Glu Met  Thr Ala Leu 
    2165                 2170                 2175             


Arg Glu  Glu Leu Lys Lys Val  Cys Gln Glu Met Tyr  Leu Thr Tyr 
    2180                 2185                 2190             


Gly Asp  Gly Glu Glu Val Gly  Gly Met Trp Val Glu  Lys Val Leu 
    2195                 2200                 2205             


Gln Leu  Tyr Gln Ile Thr Gln  Ile Asn His Gly Leu  Met Met Val 
    2210                 2215                 2220             


Gly Pro  Ser Gly Ser Gly Lys  Ser Met Ala Trp Arg  Val Leu Leu 
    2225                 2230                 2235             


Lys Ala  Leu Glu Arg Leu Glu  Gly Val Glu Gly Val  Ala His Ile 
    2240                 2245                 2250             


Ile Asp  Pro Lys Ala Ile Ser  Lys Asp His Leu Tyr  Gly Thr Leu 
    2255                 2260                 2265             


Asp Pro  Asn Thr Arg Glu Trp  Thr Asp Gly Leu Phe  Thr His Val 
    2270                 2275                 2280             


Leu Arg  Lys Ile Ile Asp Ser  Val Arg Gly Glu Leu  Gln Lys Arg 
    2285                 2290                 2295             


Gln Trp  Ile Val Phe Asp Gly  Asp Val Asp Pro Glu  Trp Val Glu 
    2300                 2305                 2310             


Asn Leu  Asn Ser Val Leu Asp  Asp Asn Lys Leu Leu  Thr Leu Pro 
    2315                 2320                 2325             


Asn Gly  Glu Arg Leu Ser Leu  Pro Pro Asn Val Arg  Ile Met Phe 
    2330                 2335                 2340             


Glu Val  Gln Asp Leu Lys Tyr  Ala Thr Leu Ala Thr  Val Ser Arg 
    2345                 2350                 2355             


Cys Gly  Met Val Trp Phe Ser  Glu Asp Val Leu Ser  Thr Asp Met 
    2360                 2365                 2370             


Ile Phe  Asn Asn Phe Leu Ala  Arg Leu Arg Ser Ile  Pro Leu Asp 
    2375                 2380                 2385             


Glu Gly  Glu Asp Glu Ala Gln  Arg Arg Arg Lys Gly  Lys Glu Asp 
    2390                 2395                 2400             


Glu Gly  Glu Glu Ala Ala Ser  Pro Met Leu Gln Ile  Gln Arg Asp 
    2405                 2410                 2415             


Ala Ala  Thr Ile Met Gln Pro  Tyr Phe Thr Ser Asn  Gly Leu Val 
    2420                 2425                 2430             


Thr Lys  Ala Leu Glu His Ala  Phe Gln Leu Glu His  Ile Met Asp 
    2435                 2440                 2445             


Leu Thr  Arg Leu Arg Cys Leu  Gly Ser Leu Phe Ser  Met Leu His 
    2450                 2455                 2460             


Gln Ala  Cys Arg Asn Val Ala  Gln Tyr Asn Ala Asn  His Pro Asp 
    2465                 2470                 2475             


Phe Pro  Met Gln Ile Glu Gln  Leu Glu Arg Tyr Ile  Gln Arg Tyr 
    2480                 2485                 2490             


Leu Val  Tyr Ala Ile Leu Trp  Ser Leu Ser Gly Asp  Ser Arg Leu 
    2495                 2500                 2505             


Lys Met  Arg Ala Glu Leu Gly  Glu Tyr Ile Arg Arg  Ile Thr Thr 
    2510                 2515                 2520             


Val Pro  Leu Pro Thr Ala Pro  Asn Ile Pro Ile Ile  Asp Tyr Glu 
    2525                 2530                 2535             


Val Ser  Ile Ser Gly Glu Trp  Ser Pro Trp Gln Ala  Lys Val Pro 
    2540                 2545                 2550             


Gln Ile  Glu Val Glu Thr His  Lys Val Ala Ala Pro  Asp Val Val 
    2555                 2560                 2565             


Val Pro  Thr Leu Asp Thr Val  Arg His Glu Ala Leu  Leu Tyr Thr 
    2570                 2575                 2580             


Trp Leu  Ala Glu His Lys Pro  Leu Val Leu Cys Gly  Pro Pro Gly 
    2585                 2590                 2595             


Ser Gly  Lys Thr Met Thr Leu  Phe Ser Ala Leu Arg  Ala Leu Pro 
    2600                 2605                 2610             


Asp Met  Glu Val Val Gly Leu  Asn Phe Ser Ser Ala  Thr Thr Pro 
    2615                 2620                 2625             


Glu Leu  Leu Leu Lys Thr Phe  Asp His Tyr Cys Glu  Tyr Arg Arg 
    2630                 2635                 2640             


Thr Pro  Asn Gly Val Val Leu  Ala Pro Val Gln Leu  Gly Lys Trp 
    2645                 2650                 2655             


Leu Val  Leu Phe Cys Asp Glu  Ile Asn Leu Pro Asp  Met Asp Lys 
    2660                 2665                 2670             


Tyr Gly  Thr Gln Arg Val Ile  Ser Phe Ile Arg Gln  Met Val Glu 
    2675                 2680                 2685             


His Gly  Gly Phe Tyr Arg Thr  Ser Asp Gln Thr Trp  Val Lys Leu 
    2690                 2695                 2700             


Glu Arg  Ile Gln Phe Val Gly  Ala Cys Asn Pro Pro  Thr Asp Pro 
    2705                 2710                 2715             


Gly Arg  Lys Pro Leu Ser His  Arg Phe Leu Arg His  Val Pro Val 
    2720                 2725                 2730             


Val Tyr  Val Asp Tyr Pro Gly  Pro Ala Ser Leu Thr  Gln Ile Tyr 
    2735                 2740                 2745             


Gly Thr  Phe Asn Arg Ala Met  Leu Arg Leu Ile Pro  Ser Leu Arg 
    2750                 2755                 2760             


Thr Tyr  Ala Glu Pro Leu Thr  Ala Ala Met Val Glu  Phe Tyr Thr 
    2765                 2770                 2775             


Met Ser  Gln Glu Arg Phe Thr  Gln Asp Thr Gln Pro  His Tyr Ile 
    2780                 2785                 2790             


Tyr Ser  Pro Arg Glu Met Thr  Arg Trp Val Arg Gly  Ile Phe Glu 
    2795                 2800                 2805             


Ala Leu  Arg Pro Leu Glu Thr  Leu Pro Val Glu Gly  Leu Ile Arg 
    2810                 2815                 2820             


Ile Trp  Ala His Glu Ala Leu  Arg Leu Phe Gln Asp  Arg Leu Val 
    2825                 2830                 2835             


Glu Asp  Glu Glu Arg Arg Trp  Thr Asp Glu Asn Ile  Asp Thr Val 
    2840                 2845                 2850             


Ala Leu  Lys His Phe Pro Asn  Ile Asp Arg Glu Lys  Ala Met Ser 
    2855                 2860                 2865             


Arg Pro  Ile Leu Tyr Ser Asn  Trp Leu Ser Lys Asp  Tyr Ile Pro 
    2870                 2875                 2880             


Val Asp  Gln Glu Glu Leu Arg  Asp Tyr Val Lys Ala  Arg Leu Lys 
    2885                 2890                 2895             


Val Phe  Tyr Glu Glu Glu Leu  Asp Val Pro Leu Val  Leu Phe Asn 
    2900                 2905                 2910             


Glu Val  Leu Asp His Val Leu  Arg Ile Asp Arg Ile  Phe Arg Gln 
    2915                 2920                 2925             


Pro Gln  Gly His Leu Leu Leu  Ile Gly Val Ser Gly  Ala Gly Lys 
    2930                 2935                 2940             


Thr Thr  Leu Ser Arg Phe Val  Ala Trp Met Asn Gly  Leu Ser Val 
    2945                 2950                 2955             


Tyr Gln  Ile Lys Val His Arg  Lys Tyr Thr Gly Glu  Asp Phe Asp 
    2960                 2965                 2970             


Glu Asp  Leu Arg Thr Val Leu  Arg Arg Ser Gly Cys  Lys Asn Glu 
    2975                 2980                 2985             


Lys Ile  Ala Phe Ile Met Asp  Glu Ser Asn Val Leu  Asp Ser Gly 
    2990                 2995                 3000             


Phe Leu  Glu Arg Met Asn Thr  Leu Leu Ala Asn Gly  Glu Val Pro 
    3005                 3010                 3015             


Gly Leu  Phe Glu Gly Asp Glu  Tyr Ala Thr Leu Met  Thr Gln Cys 
    3020                 3025                 3030             


Lys Glu  Gly Ala Gln Lys Glu  Gly Leu Met Leu Asp  Ser His Glu 
    3035                 3040                 3045             


Glu Leu  Tyr Lys Trp Phe Thr  Ser Gln Val Ile Arg  Asn Leu His 
    3050                 3055                 3060             


Val Val  Phe Thr Met Asn Pro  Ser Ser Glu Gly Leu  Lys Asp Arg 
    3065                 3070                 3075             


Ala Ala  Thr Ser Pro Ala Leu  Phe Asn Arg Cys Val  Leu Asn Trp 
    3080                 3085                 3090             


Phe Gly  Asp Trp Ser Thr Glu  Ala Leu Tyr Gln Val  Gly Lys Glu 
    3095                 3100                 3105             


Phe Thr  Ser Lys Met Asp Leu  Glu Lys Pro Asn Tyr  Ile Val Pro 
    3110                 3115                 3120             


Asp Tyr  Met Pro Val Val Tyr  Asp Lys Leu Pro Gln  Pro Pro Ser 
    3125                 3130                 3135             


His Arg  Glu Ala Ile Val Asn  Ser Cys Val Phe Val  His Gln Thr 
    3140                 3145                 3150             


Leu His  Gln Ala Asn Ala Arg  Leu Ala Lys Arg Gly  Gly Arg Thr 
    3155                 3160                 3165             


Met Ala  Ile Thr Pro Arg His  Tyr Leu Asp Phe Ile  Asn His Tyr 
    3170                 3175                 3180             


Ala Asn  Leu Phe His Glu Lys  Arg Ser Glu Leu Glu  Glu Gln Gln 
    3185                 3190                 3195             


Met His  Leu Asn Val Gly Leu  Arg Lys Ile Lys Glu  Thr Val Asp 
    3200                 3205                 3210             


Gln Val  Glu Glu Leu Arg Arg  Asp Leu Arg Ile Lys  Ser Gln Glu 
    3215                 3220                 3225             


Leu Glu  Val Lys Asn Ala Ala  Ala Asn Asp Lys Leu  Lys Lys Met 
    3230                 3235                 3240             


Val Lys  Asp Gln Gln Glu Ala  Glu Lys Lys Lys Val  Met Ser Gln 
    3245                 3250                 3255             


Glu Ile  Gln Glu Gln Leu His  Lys Gln Gln Glu Val  Ile Ala Asp 
    3260                 3265                 3270             


Lys Gln  Met Ser Val Lys Glu  Asp Leu Asp Lys Val  Glu Pro Ala 
    3275                 3280                 3285             


Val Ile  Glu Ala Gln Asn Ala  Val Lys Ser Ile Lys  Lys Gln His 
    3290                 3295                 3300             


Leu Val  Glu Val Arg Ser Met  Ala Asn Pro Pro Ala  Ala Val Lys 
    3305                 3310                 3315             


Leu Ala  Leu Glu Ser Ile Cys  Leu Leu Leu Gly Glu  Ser Thr Thr 
    3320                 3325                 3330             


Asp Trp  Lys Gln Ile Arg Ser  Ile Ile Met Arg Glu  Asn Phe Ile 
    3335                 3340                 3345             


Pro Thr  Ile Val Asn Phe Ser  Ala Glu Glu Ile Ser  Asp Ala Ile 
    3350                 3355                 3360             


Arg Glu  Lys Met Lys Lys Asn  Tyr Met Ser Asn Pro  Ser Tyr Asn 
    3365                 3370                 3375             


Tyr Glu  Ile Val Asn Arg Ala  Ser Leu Ala Cys Gly  Pro Met Val 
    3380                 3385                 3390             


Lys Trp  Ala Ile Ala Gln Leu  Asn Tyr Ala Asp Met  Leu Lys Arg 
    3395                 3400                 3405             


Val Glu  Pro Leu Arg Asn Glu  Leu Gln Lys Leu Glu  Asp Asp Ala 
    3410                 3415                 3420             


Lys Asp  Asn Gln Gln Lys Ala  Asn Glu Val Glu Gln  Met Ile Arg 
    3425                 3430                 3435             


Asp Leu  Glu Ala Ser Ile Ala  Arg Tyr Lys Glu Glu  Tyr Ala Val 
    3440                 3445                 3450             


Leu Ile  Ser Glu Ala Gln Ala  Ile Lys Ala Asp Leu  Ala Ala Val 
    3455                 3460                 3465             


Glu Ala  Lys Val Asn Arg Ser  Thr Ala Leu Leu Lys  Ser Leu Ser 
    3470                 3475                 3480             


Ala Glu  Arg Glu Arg Trp Glu  Lys Thr Ser Glu Thr  Phe Lys Asn 
    3485                 3490                 3495             


Gln Met  Ser Thr Ile Ala Gly  Asp Cys Leu Leu Ser  Ala Ala Phe 
    3500                 3505                 3510             


Ile Ala  Tyr Ala Gly Tyr Phe  Asp Gln Gln Met Arg  Gln Asn Leu 
    3515                 3520                 3525             


Phe Thr  Thr Trp Ser His His  Leu Gln Gln Ala Asn  Ile Gln Phe 
    3530                 3535                 3540             


Arg Thr  Asp Ile Ala Arg Thr  Glu Tyr Leu Ser Asn  Ala Asp Glu 
    3545                 3550                 3555             


Arg Leu  Arg Trp Gln Ala Ser  Ser Leu Pro Ala Asp  Asp Leu Cys 
    3560                 3565                 3570             


Thr Glu  Asn Ala Ile Met Leu  Lys Arg Phe Asn Arg  Tyr Pro Leu 
    3575                 3580                 3585             


Ile Ile  Asp Pro Ser Gly Gln  Ala Thr Glu Phe Ile  Met Asn Glu 
    3590                 3595                 3600             


Tyr Lys  Asp Arg Lys Ile Thr  Arg Thr Ser Phe Leu  Asp Asp Ala 
    3605                 3610                 3615             


Phe Arg  Lys Asn Leu Glu Ser  Ala Leu Arg Phe Gly  Asn Pro Leu 
    3620                 3625                 3630             


Leu Val  Gln Asp Val Glu Ser  Tyr Asp Pro Val Leu  Asn Pro Val 
    3635                 3640                 3645             


Leu Asn  Arg Glu Val Arg Arg  Thr Gly Gly Arg Val  Leu Ile Thr 
    3650                 3655                 3660             


Leu Gly  Asp Gln Asp Ile Asp  Leu Ser Pro Ser Phe  Val Ile Phe 
    3665                 3670                 3675             


Leu Ser  Thr Arg Asp Pro Thr  Val Glu Phe Pro Pro  Asp Leu Cys 
    3680                 3685                 3690             


Ser Arg  Val Thr Phe Val Asn  Phe Thr Val Thr Arg  Ser Ser Leu 
    3695                 3700                 3705             


Gln Ser  Gln Cys Leu Asn Glu  Val Leu Lys Ala Glu  Arg Pro Asp 
    3710                 3715                 3720             


Val Asp  Glu Lys Arg Ser Asp  Leu Leu Lys Leu Gln  Gly Glu Phe 
    3725                 3730                 3735             


Gln Leu  Arg Leu Arg Gln Leu  Glu Lys Ser Leu Leu  Gln Ala Leu 
    3740                 3745                 3750             


Asn Glu  Val Lys Gly Arg Ile  Leu Asp Asp Asp Thr  Ile Ile Thr 
    3755                 3760                 3765             


Thr Leu  Glu Asn Leu Lys Arg  Glu Ala Ala Glu Val  Thr Arg Lys 
    3770                 3775                 3780             


Val Glu  Glu Thr Asp Ile Val  Met Gln Glu Val Glu  Thr Val Ser 
    3785                 3790                 3795             


Gln Gln  Tyr Leu Pro Leu Ser  Thr Ala Cys Ser Ser  Ile Tyr Phe 
    3800                 3805                 3810             


Thr Met  Glu Ser Leu Lys Gln  Ile His Phe Leu Tyr  Gln Tyr Ser 
    3815                 3820                 3825             


Leu Gln  Phe Phe Leu Asp Ile  Tyr His Asn Val Leu  Tyr Glu Asn 
    3830                 3835                 3840             


Pro Asn  Leu Lys Gly Val Thr  Asp His Thr Gln Arg  Leu Ser Ile 
    3845                 3850                 3855             


Ile Thr  Lys Asp Leu Phe Gln  Val Ala Phe Asn Arg  Val Ala Arg 
    3860                 3865                 3870             


Gly Met  Leu His Gln Asp His  Ile Thr Phe Ala Met  Leu Leu Ala 
    3875                 3880                 3885             


Arg Ile  Lys Leu Lys Gly Thr  Val Gly Glu Pro Thr  Tyr Asp Ala 
    3890                 3895                 3900             


Glu Phe  Gln His Phe Leu Arg  Gly Asn Glu Ile Val  Leu Ser Ala 
    3905                 3910                 3915             


Gly Ser  Thr Pro Arg Ile Gln  Gly Leu Thr Val Glu  Gln Ala Glu 
    3920                 3925                 3930             


Ala Val  Val Arg Leu Ser Cys  Leu Pro Ala Phe Lys  Asp Leu Ile 
    3935                 3940                 3945             


Ala Lys  Val Gln Ala Asp Glu  Gln Phe Gly Ile Trp  Leu Asp Ser 
    3950                 3955                 3960             


Ser Ser  Pro Glu Gln Thr Val  Pro Tyr Leu Trp Ser  Glu Glu Thr 
    3965                 3970                 3975             


Pro Ala  Thr Pro Ile Gly Gln  Ala Ile His Arg Leu  Leu Leu Ile 
    3980                 3985                 3990             


Gln Ala  Phe Arg Pro Asp Arg  Leu Leu Ala Met Ala  His Met Phe 
    3995                 4000                 4005             


Val Ser  Thr Asn Leu Gly Glu  Ser Phe Met Ser Ile  Met Glu Gln 
    4010                 4015                 4020             


Pro Leu  Asp Leu Thr His Ile  Val Gly Thr Glu Val  Lys Pro Asn 
    4025                 4030                 4035             


Thr Pro  Val Leu Met Cys Ser  Val Pro Gly Tyr Asp  Ala Ser Gly 
    4040                 4045                 4050             


His Val  Glu Asp Leu Ala Ala  Glu Gln Asn Thr Gln  Ile Thr Ser 
    4055                 4060                 4065             


Ile Ala  Ile Gly Ser Ala Glu  Gly Phe Asn Gln Ala  Asp Lys Ala 
    4070                 4075                 4080             


Ile Asn  Thr Ala Val Lys Ser  Gly Arg Trp Val Met  Leu Lys Asn 
    4085                 4090                 4095             


Val His  Leu Ala Pro Gly Trp  Leu Met Gln Leu Glu  Lys Lys Leu 
    4100                 4105                 4110             


His Ser  Leu Gln Pro His Ala  Cys Phe Arg Leu Phe  Leu Thr Met 
    4115                 4120                 4125             


Glu Ile  Asn Pro Lys Val Pro  Val Asn Leu Leu Arg  Ala Gly Arg 
    4130                 4135                 4140             


Ile Phe  Val Phe Glu Pro Pro  Pro Gly Val Lys Ala  Asn Met Leu 
    4145                 4150                 4155             


Arg Thr  Phe Ser Ser Ile Pro  Val Ser Arg Ile Cys  Lys Ser Pro 
    4160                 4165                 4170             


Asn Glu  Arg Ala Arg Leu Tyr  Phe Leu Leu Ala Trp  Phe His Ala 
    4175                 4180                 4185             


Ile Ile  Gln Glu Arg Leu Arg  Tyr Ala Pro Leu Gly  Trp Ser Lys 
    4190                 4195                 4200             


Lys Tyr  Glu Phe Gly Glu Ser  Asp Leu Arg Ser Ala  Cys Asp Thr 
    4205                 4210                 4215             


Val Asp  Thr Trp Leu Asp Asp  Thr Ala Lys Gly Arg  Gln Asn Ile 
    4220                 4225                 4230             


Ser Pro  Asp Lys Ile Pro Trp  Ser Ala Leu Lys Thr  Leu Met Ala 
    4235                 4240                 4245             


Gln Ser  Ile Tyr Gly Gly Arg  Val Asp Asn Glu Phe  Asp Gln Arg 
    4250                 4255                 4260             


Leu Leu  Asn Thr Phe Leu Glu  Arg Leu Phe Thr Thr  Arg Ser Phe 
    4265                 4270                 4275             


Asp Ser  Glu Phe Lys Leu Ala  Cys Lys Val Asp Gly  His Lys Asp 
    4280                 4285                 4290             


Ile Gln  Met Pro Asp Gly Ile  Arg Arg Glu Glu Phe  Val Gln Trp 
    4295                 4300                 4305             


Val Glu  Leu Leu Pro Asp Thr  Gln Thr Pro Ser Trp  Leu Gly Leu 
    4310                 4315                 4320             


Pro Asn  Asn Ala Glu Arg Val  Leu Leu Thr Thr Gln  Gly Val Asp 
    4325                 4330                 4335             


Met Ile  Ser Lys Met Leu Lys  Met Gln Met Leu Glu  Asp Glu Asp 
    4340                 4345                 4350             


Asp Leu  Ala Tyr Ala Glu Thr  Glu Lys Lys Thr Arg  Thr Asp Ser 
    4355                 4360                 4365             


Thr Ser  Asp Gly Arg Pro Ala  Trp Met Arg Thr Leu  His Thr Thr 
    4370                 4375                 4380             


Ala Ser  Asn Trp Leu His Leu  Ile Pro Gln Thr Leu  Ser His Leu 
    4385                 4390                 4395             


Lys Arg  Thr Val Glu Asn Ile  Lys Asp Pro Leu Phe  Arg Phe Phe 
    4400                 4405                 4410             


Glu Arg  Glu Val Lys Met Gly  Ala Lys Leu Leu Gln  Asp Val Arg 
    4415                 4420                 4425             


Gln Asp  Leu Ala Asp Val Val  Gln Val Cys Glu Gly  Lys Lys Lys 
    4430                 4435                 4440             


Gln Thr  Asn Tyr Leu Arg Thr  Leu Ile Asn Glu Leu  Val Lys Gly 
    4445                 4450                 4455             


Ile Leu  Pro Arg Ser Trp Ser  His Tyr Thr Val Pro  Ala Gly Met 
    4460                 4465                 4470             


Thr Val  Ile Gln Trp Val Ser  Asp Phe Ser Glu Arg  Ile Lys Gln 
    4475                 4480                 4485             


Leu Gln  Asn Ile Ser Leu Ala  Ala Ala Ser Gly Gly  Ala Lys Glu 
    4490                 4495                 4500             


Leu Lys  Asn Ile His Val Cys  Leu Gly Gly Leu Phe  Val Pro Glu 
    4505                 4510                 4515             


Ala Tyr  Ile Thr Ala Thr Arg  Gln Tyr Val Ala Gln  Ala Asn Ser 
    4520                 4525                 4530             


Trp Ser  Leu Glu Glu Leu Cys  Leu Glu Val Asn Val  Thr Thr Ser 
    4535                 4540                 4545             


Gln Gly  Ala Thr Leu Asp Ala  Cys Ser Phe Gly Val  Thr Gly Leu 
    4550                 4555                 4560             


Lys Leu  Gln Gly Ala Thr Cys  Asn Asn Asn Lys Leu  Ser Leu Ser 
    4565                 4570                 4575             


Asn Ala  Ile Ser Thr Ala Leu  Pro Leu Thr Gln Leu  Arg Trp Val 
    4580                 4585                 4590             


Lys Gln  Thr Asn Thr Glu Lys  Lys Ala Ser Val Val  Thr Leu Pro 
    4595                 4600                 4605             


Val Tyr  Leu Asn Phe Thr Arg  Ala Asp Leu Ile Phe  Thr Val Asp 
    4610                 4615                 4620             


Phe Glu  Ile Ala Thr Lys Glu  Asp Pro Arg Ser Phe  Tyr Glu Arg 
    4625                 4630                 4635             


Gly Val  Ala Val Leu Cys Thr  Glu 
    4640                 4645     


<210> 237
<211> 2363
<212> PRT
<213> Homo sapiens

<400> 237
Met Glu Glu Val Pro Gly Asp Ala Leu Cys Glu His Phe Glu Ala Asn 
1               5                   10                  15      


Ile Leu Thr Gln Asn Arg Cys Gln Asn Cys Phe His Pro Glu Glu Ala 
            20                  25                  30          


His Gly Ala Arg Tyr Gln Glu Leu Arg Ser Pro Ser Gly Ala Glu Val 
        35                  40                  45              


Pro Tyr Cys Asp Leu Pro Arg Cys Pro Pro Ala Pro Glu Asp Pro Leu 
    50                  55                  60                  


Ser Ala Ser Thr Ser Gly Cys Gln Ser Val Val Asp Pro Gly Leu Arg 
65                  70                  75                  80  


Pro Gly Pro Lys Arg Gly Pro Ser Pro Ser Ala Gly Leu Pro Glu Glu 
                85                  90                  95      


Gly Pro Thr Ala Ala Pro Arg Ser Arg Ser Arg Glu Leu Glu Ala Val 
            100                 105                 110         


Pro Tyr Leu Glu Gly Leu Thr Thr Ser Leu Cys Gly Ser Cys Asn Glu 
        115                 120                 125             


Asp Pro Gly Ser Asp Pro Thr Ser Ser Pro Asp Ser Ala Thr Pro Asp 
    130                 135                 140                 


Asp Thr Ser Asn Ser Ser Ser Val Asp Trp Asp Thr Val Glu Arg Gln 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Ser Trp Asp Glu Leu Ala Val Met Ile Pro Arg 
                165                 170                 175     


Arg Pro Arg Glu Gly Pro Arg Ala Asp Ser Ser Gln Arg Ala Pro Ser 
            180                 185                 190         


Leu Leu Thr Arg Ser Pro Val Gly Gly Asp Ala Ala Gly Gln Lys Lys 
        195                 200                 205             


Glu Asp Thr Gly Gly Gly Gly Arg Ser Ala Gly Gln His Trp Ala Arg 
    210                 215                 220                 


Leu Arg Gly Glu Ser Gly Leu Ser Leu Glu Arg His Arg Ser Thr Leu 
225                 230                 235                 240 


Thr Gln Ala Ser Ser Met Thr Pro His Ser Gly Pro Arg Ser Thr Thr 
                245                 250                 255     


Ser Gln Ala Ser Pro Ala Gln Arg Asp Thr Ala Gln Ala Ala Ser Thr 
            260                 265                 270         


Arg Glu Ile Pro Arg Ala Ser Ser Pro His Arg Ile Thr Gln Arg Asp 
        275                 280                 285             


Thr Ser Arg Ala Ser Ser Thr Gln Gln Glu Ile Ser Arg Ala Ser Ser 
    290                 295                 300                 


Thr Gln Gln Glu Thr Ser Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro 
305                 310                 315                 320 


Arg Ala Ser Ser Thr Gln Glu Asp Thr Pro Arg Ala Ser Ser Thr Gln 
                325                 330                 335     


Trp Asn Thr Pro Arg Ala Ser Ser Pro Ser Arg Ser Thr Gln Leu Asp 
            340                 345                 350         


Asn Pro Arg Thr Ser Ser Thr Gln Gln Asp Asn Pro Gln Thr Ser Phe 
        355                 360                 365             


Pro Thr Cys Thr Pro Gln Arg Glu Asn Pro Arg Thr Pro Cys Val Gln 
    370                 375                 380                 


Gln Asp Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Arg Glu 
385                 390                 395                 400 


Asn Ser Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Lys Ala Ser Arg 
                405                 410                 415     


Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys 
            420                 425                 430         


Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr Arg 
        435                 440                 445             


Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser 
    450                 455                 460                 


Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser 
465                 470                 475                 480 


Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser Arg Ala Thr 
                485                 490                 495     


Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala 
            500                 505                 510         


Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg Thr 
        515                 520                 525             


Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg Ala 
    530                 535                 540                 


Ala Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg 
545                 550                 555                 560 


Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro Arg 
                565                 570                 575     


Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn Arg 
            580                 585                 590         


Ala Thr Arg Asp Asn Pro Thr Thr Ser Cys Ala Gln Arg Asp Asn Pro 
        595                 600                 605             


Arg Ala Ser Arg Thr Ser Ser Pro Asn Arg Ala Thr Arg Asp Asn Pro 
    610                 615                 620                 


Arg Thr Ser Cys Ala Gln Arg Asp Asn Pro Arg Ala Ser Ser Pro Asn 
625                 630                 635                 640 


Arg Thr Thr Gln Gln Asp Ser Pro Arg Thr Ser Cys Ala Arg Arg Asp 
                645                 650                 655     


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Pro 
            660                 665                 670         


Arg Thr Ser Cys Ala Leu Arg Asp Asn Pro Arg Ala Ser Ser Pro Ser 
        675                 680                 685             


Arg Thr Ile Gln Gln Glu Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
    690                 695                 700                 


Asp Pro Arg Ala Ser Ser Pro Asn Arg Thr Thr Gln Gln Glu Asn Pro 
705                 710                 715                 720 


Arg Thr Ser Cys Ala Arg Arg Asp Asn Pro Arg Ala Ser Ser Arg Asn 
                725                 730                 735     


Arg Thr Ile Gln Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp 
            740                 745                 750         


Asn Pro Arg Ala Ser Ser Pro Asn Arg Thr Ile Gln Gln Glu Asn Leu 
        755                 760                 765             


Arg Thr Ser Cys Thr Arg Gln Asp Asn Pro Arg Thr Ser Ser Pro Asn 
    770                 775                 780                 


Arg Ala Thr Arg Asp Asn Pro Arg Thr Ser Cys Ala Gln Arg Asp Asn 
785                 790                 795                 800 


Leu Arg Ala Ser Ser Pro Ile Arg Ala Thr Gln Gln Asp Asn Pro Arg 
                805                 810                 815     


Thr Cys Ile Gln Gln Asn Ile Pro Arg Ser Ser Ser Thr Gln Gln Asp 
            820                 825                 830         


Asn Pro Lys Thr Ser Cys Thr Lys Arg Asp Asn Leu Arg Pro Thr Cys 
        835                 840                 845             


Thr Gln Arg Asp Arg Thr Gln Ser Phe Ser Phe Gln Arg Asp Asn Pro 
    850                 855                 860                 


Gly Thr Ser Ser Ser Gln Cys Cys Thr Gln Lys Glu Asn Leu Arg Pro 
865                 870                 875                 880 


Ser Ser Pro His Arg Ser Thr Gln Trp Asn Asn Pro Arg Asn Ser Ser 
                885                 890                 895     


Pro His Arg Thr Asn Lys Asp Ile Pro Trp Ala Ser Phe Pro Leu Arg 
            900                 905                 910         


Pro Thr Gln Ser Asp Gly Pro Arg Thr Ser Ser Pro Ser Arg Ser Lys 
        915                 920                 925             


Gln Ser Glu Val Pro Trp Ala Ser Ile Ala Leu Arg Pro Thr Gln Gly 
    930                 935                 940                 


Asp Arg Pro Gln Thr Ser Ser Pro Ser Arg Pro Ala Gln His Asp Pro 
945                 950                 955                 960 


Pro Gln Ser Ser Phe Gly Pro Thr Gln Tyr Asn Leu Pro Ser Arg Ala 
                965                 970                 975     


Thr Ser Ser Ser His Asn Pro Gly His Gln Ser Thr Ser Arg Thr Ser 
            980                 985                 990         


Ser Pro Val Tyr Pro Ala Ala Tyr  Gly Ala Pro Leu Thr  Ser Pro Glu 
        995                 1000                 1005             


Pro Ser  Gln Pro Pro Cys Ala  Val Cys Ile Gly His  Arg Asp Ala 
    1010                 1015                 1020             


Pro Arg  Ala Ser Ser Pro Pro  Arg Tyr Leu Gln His  Asp Pro Phe 
    1025                 1030                 1035             


Pro Phe  Phe Pro Glu Pro Arg  Ala Pro Glu Ser Glu  Pro Pro His 
    1040                 1045                 1050             


His Glu  Pro Pro Tyr Ile Pro  Pro Ala Val Cys Ile  Gly His Arg 
    1055                 1060                 1065             


Asp Ala  Pro Arg Ala Ser Ser  Pro Pro Arg His Thr  Gln Phe Asp 
    1070                 1075                 1080             


Pro Phe  Pro Phe Leu Pro Asp  Thr Ser Asp Ala Glu  His Gln Cys 
    1085                 1090                 1095             


Gln Ser  Pro Gln His Glu Pro  Leu Gln Leu Pro Ala  Pro Val Cys 
    1100                 1105                 1110             


Ile Gly  Tyr Arg Asp Ala Pro  Arg Ala Ser Ser Pro  Pro Arg Gln 
    1115                 1120                 1125             


Ala Pro  Glu Pro Ser Leu Leu  Phe Gln Asp Leu Pro  Arg Ala Ser 
    1130                 1135                 1140             


Thr Glu  Ser Leu Val Pro Ser  Met Asp Ser Leu His  Glu Cys Pro 
    1145                 1150                 1155             


His Ile  Pro Thr Pro Val Cys  Ile Gly His Arg Asp  Ala Pro Ser 
    1160                 1165                 1170             


Phe Ser  Ser Pro Pro Arg Gln  Ala Pro Glu Pro Ser  Leu Phe Phe 
    1175                 1180                 1185             


Gln Asp  Pro Pro Gly Thr Ser  Met Glu Ser Leu Ala  Pro Ser Thr 
    1190                 1195                 1200             


Asp Ser  Leu His Gly Ser Pro  Val Leu Ile Pro Gln  Val Cys Ile 
    1205                 1210                 1215             


Gly His  Arg Asp Ala Pro Arg  Ala Ser Ser Pro Pro  Arg His Pro 
    1220                 1225                 1230             


Pro Ser  Asp Leu Ala Phe Leu  Ala Pro Ser Pro Ser  Pro Gly Ser 
    1235                 1240                 1245             


Ser Gly  Gly Ser Arg Gly Ser  Ala Pro Pro Gly Glu  Thr Arg His 
    1250                 1255                 1260             


Asn Leu  Glu Arg Glu Glu Tyr  Thr Val Leu Ala Asp  Leu Pro Pro 
    1265                 1270                 1275             


Pro Arg  Arg Leu Ala Gln Arg  Gln Pro Gly Pro Gln  Ala Gln Cys 
    1280                 1285                 1290             


Ser Ser  Gly Gly Arg Thr His  Ser Pro Gly Arg Ala  Glu Val Glu 
    1295                 1300                 1305             


Arg Leu  Phe Gly Gln Glu Arg  Arg Lys Ser Glu Ala  Ala Gly Ala 
    1310                 1315                 1320             


Phe Gln  Ala Gln Asp Glu Gly  Arg Ser Gln Gln Pro  Ser Gln Gly 
    1325                 1330                 1335             


Gln Ser  Gln Leu Leu Arg Arg  Gln Ser Ser Pro Ala  Pro Ser Arg 
    1340                 1345                 1350             


Gln Val  Thr Met Leu Pro Ala  Lys Gln Ala Glu Leu  Thr Arg Arg 
    1355                 1360                 1365             


Ser Gln  Ala Glu Pro Pro His  Pro Trp Ser Pro Glu  Lys Arg Pro 
    1370                 1375                 1380             


Glu Gly  Asp Arg Gln Leu Gln  Gly Ser Pro Leu Pro  Pro Arg Thr 
    1385                 1390                 1395             


Ser Ala  Arg Thr Pro Glu Arg  Glu Leu Arg Thr Gln  Arg Pro Leu 
    1400                 1405                 1410             


Glu Ser  Gly Gln Ala Gly Pro  Arg Gln Pro Leu Gly  Val Trp Gln 
    1415                 1420                 1425             


Ser Gln  Glu Glu Pro Pro Gly  Ser Gln Gly Pro His  Arg His Leu 
    1430                 1435                 1440             


Glu Arg  Ser Trp Ser Ser Gln  Glu Gly Gly Leu Gly  Pro Gly Gly 
    1445                 1450                 1455             


Trp Trp  Gly Cys Gly Glu Pro  Ser Leu Gly Ala Ala  Lys Ala Pro 
    1460                 1465                 1470             


Glu Gly  Ala Trp Gly Gly Thr  Ser Arg Glu Tyr Lys  Glu Ser Trp 
    1475                 1480                 1485             


Gly Gln  Pro Glu Ala Trp Glu  Glu Lys Pro Thr His  Glu Leu Pro 
    1490                 1495                 1500             


Arg Glu  Leu Gly Lys Arg Ser  Pro Leu Thr Ser Pro  Pro Glu Asn 
    1505                 1510                 1515             


Trp Gly  Gly Pro Ala Glu Ser  Ser Gln Ser Trp His  Ser Gly Thr 
    1520                 1525                 1530             


Pro Thr  Ala Val Gly Trp Gly  Ala Glu Gly Ala Cys  Pro Tyr Pro 
    1535                 1540                 1545             


Arg Gly  Ser Glu Arg Arg Pro  Glu Leu Asp Trp Arg  Asp Leu Leu 
    1550                 1555                 1560             


Gly Leu  Leu Arg Ala Pro Gly  Glu Gly Val Trp Ala  Arg Val Pro 
    1565                 1570                 1575             


Ser Leu  Asp Trp Glu Gly Leu  Leu Glu Leu Leu Gln  Ala Arg Leu 
    1580                 1585                 1590             


Pro Arg  Lys Asp Pro Ala Gly  His Arg Asp Asp Leu  Ala Arg Ala 
    1595                 1600                 1605             


Leu Gly  Pro Glu Leu Gly Pro  Pro Gly Thr Asn Asp  Val Pro Glu 
    1610                 1615                 1620             


Gln Glu  Ser His Ser Gln Pro  Glu Gly Trp Ala Glu  Ala Thr Pro 
    1625                 1630                 1635             


Val Asn  Gly His Ser Pro Ala  Leu Gln Ser Gln Ser  Pro Val Gln 
    1640                 1645                 1650             


Leu Pro  Ser Ala Cys Thr Ser  Thr Gln Trp Pro Lys  Ile Lys Val 
    1655                 1660                 1665             


Thr Arg  Gly Pro Ala Thr Ala  Thr Leu Ala Gly Leu  Glu Gln Thr 
    1670                 1675                 1680             


Gly Pro  Leu Gly Ser Arg Ser  Thr Ala Lys Gly Pro  Ser Leu Pro 
    1685                 1690                 1695             


Glu Leu  Gln Phe Gln Pro Glu  Glu Pro Glu Glu Ser  Glu Pro Ser 
    1700                 1705                 1710             


Arg Gly  Asp Pro Leu Thr Asp  Gln Lys Gln Ala Asp  Ser Ala Asp 
    1715                 1720                 1725             


Lys Arg  Pro Ala Glu Gly Lys  Ala Gly Ser Pro Leu  Lys Gly Arg 
    1730                 1735                 1740             


Leu Val  Thr Ser Trp Arg Met  Pro Gly Asp Arg Pro  Thr Leu Phe 
    1745                 1750                 1755             


Asn Pro  Phe Leu Leu Ser Leu  Gly Val Leu Arg Trp  Arg Arg Pro 
    1760                 1765                 1770             


Asp Leu  Leu Asn Phe Lys Lys  Gly Trp Met Ser Ile  Leu Asp Glu 
    1775                 1780                 1785             


Pro Gly  Glu Pro Pro Ser Pro  Ser Leu Thr Thr Thr  Ser Thr Ser 
    1790                 1795                 1800             


Gln Trp  Lys Lys His Trp Phe  Val Leu Thr Asp Ser  Ser Leu Lys 
    1805                 1810                 1815             


Tyr Tyr  Arg Asp Ser Thr Ala  Glu Glu Ala Asp Glu  Leu Asp Gly 
    1820                 1825                 1830             


Glu Ile  Asp Leu Arg Ser Cys  Thr Asp Val Thr Glu  Tyr Ala Val 
    1835                 1840                 1845             


Gln Arg  Asn Tyr Gly Phe Gln  Ile His Thr Lys Asp  Ala Val Tyr 
    1850                 1855                 1860             


Thr Leu  Ser Ala Met Thr Ser  Gly Ile Arg Arg Asn  Trp Ile Glu 
    1865                 1870                 1875             


Ala Leu  Arg Lys Thr Val Arg  Pro Thr Ser Ala Pro  Asp Val Thr 
    1880                 1885                 1890             


Lys Leu  Ser Asp Ser Asn Lys  Glu Asn Ala Leu His  Ser Tyr Ser 
    1895                 1900                 1905             


Thr Gln  Lys Gly Pro Leu Lys  Ala Gly Glu Gln Arg  Ala Gly Ser 
    1910                 1915                 1920             


Glu Val  Ile Ser Arg Gly Gly  Pro Arg Lys Ala Asp  Gly Gln Arg 
    1925                 1930                 1935             


Gln Ala  Leu Asp Tyr Val Glu  Leu Ser Pro Leu Thr  Gln Ala Ser 
    1940                 1945                 1950             


Pro Gln  Arg Ala Arg Thr Pro  Ala Arg Thr Pro Asp  Arg Leu Ala 
    1955                 1960                 1965             


Lys Gln  Glu Glu Leu Glu Arg  Asp Leu Ala Gln Arg  Ser Glu Glu 
    1970                 1975                 1980             


Arg Arg  Lys Trp Phe Glu Ala  Thr Asp Ser Arg Thr  Pro Glu Val 
    1985                 1990                 1995             


Pro Ala  Gly Glu Gly Pro Arg  Arg Gly Leu Gly Ala  Pro Leu Thr 
    2000                 2005                 2010             


Glu Asp  Gln Gln Asn Arg Leu  Ser Glu Glu Ile Glu  Lys Lys Trp 
    2015                 2020                 2025             


Gln Glu  Leu Glu Lys Leu Pro  Leu Arg Glu Asn Lys  Arg Val Pro 
    2030                 2035                 2040             


Leu Thr  Ala Leu Leu Asn Gln  Ser Arg Gly Glu Arg  Arg Gly Pro 
    2045                 2050                 2055             


Pro Ser  Asp Gly His Glu Ala  Leu Glu Lys Glu Val  Gln Ala Leu 
    2060                 2065                 2070             


Arg Ala  Gln Leu Glu Ala Trp  Arg Leu Gln Gly Glu  Ala Pro Gln 
    2075                 2080                 2085             


Ser Ala  Leu Arg Ser Gln Glu  Asp Gly His Ile Pro  Pro Gly Tyr 
    2090                 2095                 2100             


Ile Ser  Gln Glu Ala Cys Glu  Arg Ser Leu Ala Glu  Met Glu Ser 
    2105                 2110                 2115             


Ser His  Gln Gln Val Met Glu  Glu Leu Gln Arg His  His Glu Arg 
    2120                 2125                 2130             


Glu Leu  Gln Arg Leu Gln Gln  Glu Lys Glu Trp Leu  Leu Ala Glu 
    2135                 2140                 2145             


Glu Thr  Ala Ala Thr Ala Ser  Ala Ile Glu Ala Met  Lys Lys Ala 
    2150                 2155                 2160             


Tyr Gln  Glu Glu Leu Ser Arg  Glu Leu Ser Lys Thr  Arg Ser Leu 
    2165                 2170                 2175             


Gln Gln  Gly Pro Asp Gly Leu  Arg Lys Gln His Gln  Ser Asp Val 
    2180                 2185                 2190             


Glu Ala  Leu Lys Arg Glu Leu  Gln Val Leu Ser Glu  Gln Tyr Ser 
    2195                 2200                 2205             


Gln Lys  Cys Leu Glu Ile Gly  Ala Leu Met Arg Gln  Ala Glu Glu 
    2210                 2215                 2220             


Arg Glu  His Thr Leu Arg Arg  Cys Gln Gln Glu Gly  Gln Glu Leu 
    2225                 2230                 2235             


Leu Arg  His Asn Gln Glu Leu  His Gly Arg Leu Ser  Glu Glu Ile 
    2240                 2245                 2250             


Asp Gln  Leu Arg Gly Phe Ile  Ala Ser Gln Gly Met  Gly Asn Gly 
    2255                 2260                 2265             


Cys Gly  Arg Ser Asn Glu Arg  Ser Ser Cys Glu Leu  Glu Val Leu 
    2270                 2275                 2280             


Leu Arg  Val Lys Glu Asn Glu  Leu Gln Tyr Leu Lys  Lys Glu Val 
    2285                 2290                 2295             


Gln Cys  Leu Arg Asp Glu Leu  Gln Met Met Gln Lys  Asp Lys Arg 
    2300                 2305                 2310             


Phe Thr  Ser Gly Lys Tyr Gln  Asp Val Tyr Val Glu  Leu Ser His 
    2315                 2320                 2325             


Ile Lys  Thr Arg Ser Glu Arg  Glu Ile Glu Gln Leu  Lys Glu His 
    2330                 2335                 2340             


Leu Arg  Leu Ala Met Ala Ala  Leu Gln Glu Lys Glu  Ser Met Arg 
    2345                 2350                 2355             


Asn Ser  Leu Ala Glu 
    2360             


<210> 238
<211> 2554
<212> PRT
<213> Homo sapiens

<400> 238
Met Thr Ala Thr Thr Arg Gly Ser Pro Val Gly Gly Asn Asp Asn Gln 
1               5                   10                  15      


Gly Gln Ala Pro Asp Gly Gln Ser Gln Pro Pro Leu Gln Gln Asn Gln 
            20                  25                  30          


Thr Ser Ser Pro Asp Ser Ser Asn Glu Asn Ser Pro Ala Thr Pro Pro 
        35                  40                  45              


Asp Glu Gln Gly Gln Gly Asp Ala Pro Pro Gln Leu Glu Asp Glu Glu 
    50                  55                  60                  


Pro Ala Phe Pro His Thr Asp Leu Ala Lys Leu Asp Asp Met Ile Asn 
65                  70                  75                  80  


Arg Pro Arg Trp Val Val Pro Val Leu Pro Lys Gly Glu Leu Glu Val 
                85                  90                  95      


Leu Leu Glu Ala Ala Ile Asp Leu Ser Lys Lys Gly Leu Asp Val Lys 
            100                 105                 110         


Ser Glu Ala Cys Gln Arg Phe Phe Arg Asp Gly Leu Thr Ile Ser Phe 
        115                 120                 125             


Thr Lys Ile Leu Thr Asp Glu Ala Val Ser Gly Trp Lys Phe Glu Ile 
    130                 135                 140                 


His Arg Cys Ile Ile Asn Asn Thr His Arg Leu Val Glu Leu Cys Val 
145                 150                 155                 160 


Ala Lys Leu Ser Gln Asp Trp Phe Pro Leu Leu Glu Leu Leu Ala Met 
                165                 170                 175     


Ala Leu Asn Pro His Cys Lys Phe His Ile Tyr Asn Gly Thr Arg Pro 
            180                 185                 190         


Cys Glu Ser Val Ser Ser Ser Val Gln Leu Pro Glu Asp Glu Leu Phe 
        195                 200                 205             


Ala Arg Ser Pro Asp Pro Arg Ser Pro Lys Gly Trp Leu Val Asp Leu 
    210                 215                 220                 


Leu Asn Lys Phe Gly Thr Leu Asn Gly Phe Gln Ile Leu His Asp Arg 
225                 230                 235                 240 


Phe Ile Asn Gly Ser Ala Leu Asn Val Gln Ile Ile Ala Ala Leu Ile 
                245                 250                 255     


Lys Pro Phe Gly Gln Cys Tyr Glu Phe Leu Thr Leu His Thr Val Lys 
            260                 265                 270         


Lys Tyr Phe Leu Pro Ile Ile Glu Met Val Pro Gln Phe Leu Glu Asn 
        275                 280                 285             


Leu Thr Asp Glu Glu Leu Lys Lys Glu Ala Lys Asn Glu Ala Lys Asn 
    290                 295                 300                 


Asp Ala Leu Ser Met Ile Ile Lys Ser Leu Lys Asn Leu Ala Ser Arg 
305                 310                 315                 320 


Val Pro Gly Gln Glu Glu Thr Val Lys Asn Leu Glu Ile Phe Arg Leu 
                325                 330                 335     


Lys Met Ile Leu Arg Leu Leu Gln Ile Ser Ser Phe Asn Gly Lys Met 
            340                 345                 350         


Asn Ala Leu Asn Glu Val Asn Lys Val Ile Ser Ser Val Ser Tyr Tyr 
        355                 360                 365             


Thr His Arg His Gly Asn Pro Glu Glu Glu Glu Trp Leu Thr Ala Glu 
    370                 375                 380                 


Arg Met Ala Glu Trp Ile Gln Gln Asn Asn Ile Leu Ser Ile Val Leu 
385                 390                 395                 400 


Arg Asp Ser Leu His Gln Pro Gln Tyr Val Glu Lys Leu Glu Lys Ile 
                405                 410                 415     


Leu Arg Phe Val Ile Lys Glu Lys Ala Leu Thr Leu Gln Asp Leu Asp 
            420                 425                 430         


Asn Ile Trp Ala Ala Gln Ala Gly Lys His Glu Ala Ile Val Lys Asn 
        435                 440                 445             


Val His Asp Leu Leu Ala Lys Leu Ala Trp Asp Phe Ser Pro Glu Gln 
    450                 455                 460                 


Leu Asp His Leu Phe Asp Cys Phe Lys Ala Ser Trp Thr Asn Ala Ser 
465                 470                 475                 480 


Lys Lys Gln Arg Glu Lys Leu Leu Glu Leu Ile Arg Arg Leu Ala Glu 
                485                 490                 495     


Asp Asp Lys Asp Gly Val Met Ala His Lys Val Leu Asn Leu Leu Trp 
            500                 505                 510         


Asn Leu Ala His Ser Asp Asp Val Pro Val Asp Ile Met Asp Leu Ala 
        515                 520                 525             


Leu Ser Ala His Ile Lys Ile Leu Asp Tyr Ser Cys Ser Gln Asp Arg 
    530                 535                 540                 


Asp Thr Gln Lys Ile Gln Trp Ile Asp Arg Phe Ile Glu Glu Leu Arg 
545                 550                 555                 560 


Thr Asn Asp Lys Trp Val Ile Pro Ala Leu Lys Gln Ile Arg Glu Ile 
                565                 570                 575     


Cys Ser Leu Phe Gly Glu Ala Pro Gln Asn Leu Ser Gln Thr Gln Arg 
            580                 585                 590         


Ser Pro His Val Phe Tyr Arg His Asp Leu Ile Asn Gln Leu Gln His 
        595                 600                 605             


Asn His Ala Leu Val Thr Leu Val Ala Glu Asn Leu Ala Thr Tyr Met 
    610                 615                 620                 


Glu Ser Met Arg Leu Tyr Ala Arg Asp His Glu Asp Tyr Asp Pro Gln 
625                 630                 635                 640 


Thr Val Arg Leu Gly Ser Arg Tyr Ser His Val Gln Glu Val Gln Glu 
                645                 650                 655     


Arg Leu Asn Phe Leu Arg Phe Leu Leu Lys Asp Gly Gln Leu Trp Leu 
            660                 665                 670         


Cys Ala Pro Gln Ala Lys Gln Ile Trp Lys Cys Leu Ala Glu Asn Ala 
        675                 680                 685             


Val Tyr Leu Cys Asp Arg Glu Ala Cys Phe Lys Trp Tyr Ser Lys Leu 
    690                 695                 700                 


Met Gly Asp Glu Pro Asp Leu Asp Pro Asp Ile Asn Lys Asp Phe Phe 
705                 710                 715                 720 


Glu Ser Asn Val Leu Gln Leu Asp Pro Ser Leu Leu Thr Glu Asn Gly 
                725                 730                 735     


Met Lys Cys Phe Glu Arg Phe Phe Lys Ala Val Asn Cys Arg Glu Gly 
            740                 745                 750         


Lys Leu Val Ala Lys Arg Arg Ala Tyr Met Met Asp Asp Leu Glu Leu 
        755                 760                 765             


Ile Gly Leu Asp Tyr Leu Trp Arg Val Val Ile Gln Ser Asn Asp Asp 
    770                 775                 780                 


Ile Ala Ser Arg Ala Ile Asp Leu Leu Lys Glu Ile Tyr Thr Asn Leu 
785                 790                 795                 800 


Gly Pro Arg Leu Gln Val Asn Gln Val Val Ile His Glu Asp Phe Ile 
                805                 810                 815     


Gln Ser Cys Phe Asp Arg Leu Lys Ala Ser Tyr Asp Thr Leu Cys Val 
            820                 825                 830         


Leu Asp Gly Asp Lys Asp Ser Val Asn Cys Ala Arg Gln Glu Ala Val 
        835                 840                 845             


Arg Met Val Arg Val Leu Thr Val Leu Arg Glu Tyr Ile Asn Glu Cys 
    850                 855                 860                 


Asp Ser Asp Tyr His Glu Glu Arg Thr Ile Leu Pro Met Ser Arg Ala 
865                 870                 875                 880 


Phe Arg Gly Lys His Leu Ser Phe Val Val Arg Phe Pro Asn Gln Gly 
                885                 890                 895     


Arg Gln Val Asp Asp Leu Glu Val Trp Ser His Thr Asn Asp Thr Ile 
            900                 905                 910         


Gly Ser Val Arg Arg Cys Ile Leu Asn Arg Ile Lys Ala Asn Val Ala 
        915                 920                 925             


His Thr Lys Ile Glu Leu Phe Val Gly Gly Glu Leu Ile Asp Pro Ala 
    930                 935                 940                 


Asp Asp Arg Lys Leu Ile Gly Gln Leu Asn Leu Lys Asp Lys Ser Leu 
945                 950                 955                 960 


Ile Thr Ala Lys Leu Thr Gln Ile Ser Ser Asn Met Pro Ser Ser Pro 
                965                 970                 975     


Asp Ser Ser Ser Asp Ser Ser Thr Gly Ser Pro Gly Asn His Gly Asn 
            980                 985                 990         


His Tyr Ser Asp Gly Pro Asn Pro  Glu Val Glu Ser Cys  Leu Pro Gly 
        995                 1000                 1005             


Val Ile  Met Ser Leu His Pro  Arg Tyr Ile Ser Phe  Leu Trp Gln 
    1010                 1015                 1020             


Val Ala  Asp Leu Gly Ser Ser  Leu Asn Met Pro Pro  Leu Arg Asp 
    1025                 1030                 1035             


Gly Ala  Arg Val Leu Met Lys  Leu Met Pro Pro Asp  Ser Thr Thr 
    1040                 1045                 1050             


Ile Glu  Lys Leu Arg Ala Ile  Cys Leu Asp His Ala  Lys Leu Gly 
    1055                 1060                 1065             


Glu Ser  Ser Leu Ser Pro Ser  Leu Asp Ser Leu Phe  Phe Gly Pro 
    1070                 1075                 1080             


Ser Ala  Ser Gln Val Leu Tyr  Leu Thr Glu Val Val  Tyr Ala Leu 
    1085                 1090                 1095             


Leu Met  Pro Ala Gly Ala Pro  Leu Ala Asp Asp Ser  Ser Asp Phe 
    1100                 1105                 1110             


Gln Phe  His Phe Leu Lys Ser  Gly Gly Leu Pro Leu  Val Leu Ser 
    1115                 1120                 1125             


Met Leu  Thr Arg Asn Asn Phe  Leu Pro Asn Ala Asp  Met Glu Thr 
    1130                 1135                 1140             


Arg Arg  Gly Ala Tyr Leu Asn  Ala Leu Lys Ile Ala  Lys Leu Leu 
    1145                 1150                 1155             


Leu Thr  Ala Ile Gly Tyr Gly  His Val Arg Ala Val  Ala Glu Ala 
    1160                 1165                 1170             


Cys Gln  Pro Gly Val Glu Gly  Val Asn Pro Met Thr  Gln Ile Asn 
    1175                 1180                 1185             


Gln Val  Thr His Asp Gln Ala  Val Val Leu Gln Ser  Ala Leu Gln 
    1190                 1195                 1200             


Ser Ile  Pro Asn Pro Ser Ser  Glu Cys Met Leu Arg  Asn Val Ser 
    1205                 1210                 1215             


Val Arg  Leu Ala Gln Gln Ile  Ser Asp Glu Ala Ser  Arg Tyr Met 
    1220                 1225                 1230             


Pro Asp  Ile Cys Val Ile Arg  Ala Ile Gln Lys Ile  Ile Trp Ala 
    1235                 1240                 1245             


Ser Gly  Cys Gly Ser Leu Gln  Leu Val Phe Ser Pro  Asn Glu Glu 
    1250                 1255                 1260             


Ile Thr  Lys Ile Tyr Glu Lys  Thr Asn Ala Gly Asn  Glu Pro Asp 
    1265                 1270                 1275             


Leu Glu  Asp Glu Gln Val Cys  Cys Glu Ala Leu Glu  Val Met Thr 
    1280                 1285                 1290             


Leu Cys  Phe Ala Leu Ile Pro  Thr Ala Leu Asp Ala  Leu Ser Lys 
    1295                 1300                 1305             


Glu Lys  Ala Trp Gln Thr Phe  Ile Ile Asp Leu Leu  Leu His Cys 
    1310                 1315                 1320             


His Ser  Lys Thr Val Arg Gln  Val Ala Gln Glu Gln  Phe Phe Leu 
    1325                 1330                 1335             


Met Cys  Thr Arg Cys Cys Met  Gly His Arg Pro Leu  Leu Phe Phe 
    1340                 1345                 1350             


Ile Thr  Leu Leu Phe Thr Val  Leu Gly Ser Thr Ala  Arg Glu Arg 
    1355                 1360                 1365             


Ala Lys  His Ser Gly Asp Tyr  Phe Thr Leu Leu Arg  His Leu Leu 
    1370                 1375                 1380             


Asn Tyr  Ala Tyr Asn Ser Asn  Ile Asn Val Pro Asn  Ala Glu Val 
    1385                 1390                 1395             


Leu Leu  Asn Asn Glu Ile Asp  Trp Leu Lys Arg Ile  Arg Asp Asp 
    1400                 1405                 1410             


Val Lys  Arg Thr Gly Glu Thr  Gly Ile Glu Glu Thr  Ile Leu Glu 
    1415                 1420                 1425             


Gly His  Leu Gly Val Thr Lys  Glu Leu Leu Ala Phe  Gln Thr Ser 
    1430                 1435                 1440             


Glu Lys  Lys Phe His Ile Gly  Cys Glu Lys Gly Gly  Ala Asn Leu 
    1445                 1450                 1455             


Ile Lys  Glu Leu Ile Asp Asp  Phe Ile Phe Pro Ala  Ser Asn Val 
    1460                 1465                 1470             


Tyr Leu  Gln Tyr Met Arg Asn  Gly Glu Leu Pro Ala  Glu Gln Ala 
    1475                 1480                 1485             


Ile Pro  Val Cys Gly Ser Pro  Pro Thr Ile Asn Ala  Gly Phe Glu 
    1490                 1495                 1500             


Leu Leu  Val Ala Leu Ala Val  Gly Cys Val Arg Asn  Leu Lys Gln 
    1505                 1510                 1515             


Ile Val  Asp Ser Leu Thr Glu  Met Tyr Tyr Ile Gly  Thr Ala Ile 
    1520                 1525                 1530             


Thr Thr  Cys Glu Ala Leu Thr  Glu Trp Glu Tyr Leu  Pro Pro Val 
    1535                 1540                 1545             


Gly Pro  Arg Pro Pro Lys Gly  Phe Val Gly Leu Lys  Asn Ala Gly 
    1550                 1555                 1560             


Ala Thr  Cys Tyr Met Asn Ser  Val Ile Gln Gln Leu  Tyr Met Ile 
    1565                 1570                 1575             


Pro Ser  Ile Arg Asn Gly Ile  Leu Ala Ile Glu Gly  Thr Gly Ser 
    1580                 1585                 1590             


Asp Val  Asp Asp Asp Met Ser  Gly Asp Glu Lys Gln  Asp Asn Glu 
    1595                 1600                 1605             


Ser Asn  Val Asp Pro Arg Asp  Asp Val Phe Gly Tyr  Pro Gln Gln 
    1610                 1615                 1620             


Phe Glu  Asp Lys Pro Ala Leu  Ser Lys Thr Glu Asp  Arg Lys Glu 
    1625                 1630                 1635             


Tyr Asn  Ile Gly Val Leu Arg  His Leu Gln Val Ile  Phe Gly His 
    1640                 1645                 1650             


Leu Ala  Ala Ser Arg Leu Gln  Tyr Tyr Val Pro Arg  Gly Phe Trp 
    1655                 1660                 1665             


Lys Gln  Phe Arg Leu Trp Gly  Glu Pro Val Asn Leu  Arg Glu Gln 
    1670                 1675                 1680             


His Asp  Ala Leu Glu Phe Phe  Asn Ser Leu Val Asp  Ser Leu Asp 
    1685                 1690                 1695             


Glu Ala  Leu Lys Ala Leu Gly  His Pro Ala Met Leu  Ser Lys Val 
    1700                 1705                 1710             


Leu Gly  Gly Ser Phe Ala Asp  Gln Lys Ile Cys Gln  Gly Cys Pro 
    1715                 1720                 1725             


His Arg  Tyr Glu Cys Glu Glu  Ser Phe Thr Thr Leu  Asn Val Asp 
    1730                 1735                 1740             


Ile Arg  Asn His Gln Asn Leu  Leu Asp Ser Leu Glu  Gln Tyr Val 
    1745                 1750                 1755             


Lys Gly  Asp Leu Leu Glu Gly  Ala Asn Ala Tyr His  Cys Glu Lys 
    1760                 1765                 1770             


Cys Asn  Lys Lys Val Asp Thr  Val Lys Arg Leu Leu  Ile Lys Lys 
    1775                 1780                 1785             


Leu Pro  Pro Val Leu Ala Ile  Gln Leu Lys Arg Phe  Asp Tyr Asp 
    1790                 1795                 1800             


Trp Glu  Arg Glu Cys Ala Ile  Lys Phe Asn Asp Tyr  Phe Glu Phe 
    1805                 1810                 1815             


Pro Arg  Glu Leu Asp Met Glu  Pro Tyr Thr Val Ala  Gly Val Ala 
    1820                 1825                 1830             


Lys Leu  Glu Gly Asp Asn Val  Asn Pro Glu Ser Gln  Leu Ile Gln 
    1835                 1840                 1845             


Gln Ser  Glu Gln Ser Glu Ser  Glu Thr Ala Gly Ser  Thr Lys Tyr 
    1850                 1855                 1860             


Arg Leu  Val Gly Val Leu Val  His Ser Gly Gln Ala  Ser Gly Gly 
    1865                 1870                 1875             


His Tyr  Tyr Ser Tyr Ile Ile  Gln Arg Asn Gly Gly  Asp Gly Glu 
    1880                 1885                 1890             


Arg Asn  Arg Trp Tyr Lys Phe  Asp Asp Gly Asp Val  Thr Glu Cys 
    1895                 1900                 1905             


Lys Met  Asp Asp Asp Glu Glu  Met Lys Asn Gln Cys  Phe Gly Gly 
    1910                 1915                 1920             


Glu Tyr  Met Gly Glu Val Phe  Asp His Met Met Lys  Arg Met Ser 
    1925                 1930                 1935             


Tyr Arg  Arg Gln Lys Arg Trp  Trp Asn Ala Tyr Ile  Leu Phe Tyr 
    1940                 1945                 1950             


Glu Arg  Met Asp Thr Ile Asp  Gln Asp Asp Glu Leu  Ile Arg Tyr 
    1955                 1960                 1965             


Ile Ser  Glu Leu Ala Ile Thr  Thr Arg Pro His Gln  Ile Ile Met 
    1970                 1975                 1980             


Pro Ser  Ala Ile Glu Arg Ser  Val Arg Lys Gln Asn  Val Gln Phe 
    1985                 1990                 1995             


Met His  Asn Arg Met Gln Tyr  Ser Met Glu Tyr Phe  Gln Phe Met 
    2000                 2005                 2010             


Lys Lys  Leu Leu Thr Cys Asn  Gly Val Tyr Leu Asn  Pro Pro Pro 
    2015                 2020                 2025             


Gly Gln  Asp His Leu Leu Pro  Glu Ala Glu Glu Ile  Thr Met Ile 
    2030                 2035                 2040             


Ser Ile  Gln Leu Ala Ala Arg  Phe Leu Phe Thr Thr  Gly Phe His 
    2045                 2050                 2055             


Thr Lys  Lys Val Val Arg Gly  Ser Ala Ser Asp Trp  Tyr Asp Ala 
    2060                 2065                 2070             


Leu Cys  Ile Leu Leu Arg His  Ser Lys Asn Val Arg  Phe Trp Phe 
    2075                 2080                 2085             


Ala His  Asn Val Leu Phe Asn  Val Ser Asn Arg Phe  Ser Glu Tyr 
    2090                 2095                 2100             


Leu Leu  Glu Cys Pro Ser Ala  Glu Val Arg Gly Ala  Phe Ala Lys 
    2105                 2110                 2115             


Leu Ile  Val Phe Ile Ala His  Phe Ser Leu Gln Asp  Gly Pro Cys 
    2120                 2125                 2130             


Pro Ser  Pro Phe Ala Ser Pro  Gly Pro Ser Ser Gln  Ala Tyr Asp 
    2135                 2140                 2145             


Asn Leu  Ser Leu Ser Asp His  Leu Leu Arg Ala Val  Leu Asn Leu 
    2150                 2155                 2160             


Leu Arg  Arg Glu Val Ser Glu  His Gly Arg His Leu  Gln Gln Tyr 
    2165                 2170                 2175             


Phe Asn  Leu Phe Val Met Tyr  Ala Asn Leu Gly Val  Ala Glu Lys 
    2180                 2185                 2190             


Thr Gln  Leu Leu Lys Leu Ser  Val Pro Ala Thr Phe  Met Leu Val 
    2195                 2200                 2205             


Ser Leu  Asp Glu Gly Pro Gly  Pro Pro Ile Lys Tyr  Gln Tyr Ala 
    2210                 2215                 2220             


Glu Leu  Gly Lys Leu Tyr Ser  Val Val Ser Gln Leu  Ile Arg Cys 
    2225                 2230                 2235             


Cys Asn  Val Ser Ser Arg Met  Gln Ser Ser Ile Asn  Gly Asn Pro 
    2240                 2245                 2250             


Pro Leu  Pro Asn Pro Phe Gly  Asp Pro Asn Leu Ser  Gln Pro Ile 
    2255                 2260                 2265             


Met Pro  Ile Gln Gln Asn Val  Ala Asp Ile Leu Phe  Val Arg Thr 
    2270                 2275                 2280             


Ser Tyr  Val Lys Lys Ile Ile  Glu Asp Cys Ser Asn  Ser Glu Glu 
    2285                 2290                 2295             


Thr Val  Lys Leu Leu Arg Phe  Cys Cys Trp Glu Asn  Pro Gln Phe 
    2300                 2305                 2310             


Ser Ser  Thr Val Leu Ser Glu  Leu Leu Trp Gln Val  Ala Tyr Ser 
    2315                 2320                 2325             


Tyr Thr  Tyr Glu Leu Arg Pro  Tyr Leu Asp Leu Leu  Leu Gln Ile 
    2330                 2335                 2340             


Leu Leu  Ile Glu Asp Ser Trp  Gln Thr His Arg Ile  His Asn Ala 
    2345                 2350                 2355             


Leu Lys  Gly Ile Pro Asp Asp  Arg Asp Gly Leu Phe  Asp Thr Ile 
    2360                 2365                 2370             


Gln Arg  Ser Lys Asn His Tyr  Gln Lys Arg Ala Tyr  Gln Cys Ile 
    2375                 2380                 2385             


Lys Cys  Met Val Ala Leu Phe  Ser Asn Cys Pro Val  Ala Tyr Gln 
    2390                 2395                 2400             


Ile Leu  Gln Gly Asn Gly Asp  Leu Lys Arg Lys Trp  Thr Trp Ala 
    2405                 2410                 2415             


Val Glu  Trp Leu Gly Asp Glu  Leu Glu Arg Arg Pro  Tyr Thr Gly 
    2420                 2425                 2430             


Asn Pro  Gln Tyr Thr Tyr Asn  Asn Trp Ser Pro Pro  Val Gln Ser 
    2435                 2440                 2445             


Asn Glu  Thr Ser Asn Gly Tyr  Phe Leu Glu Arg Ser  His Ser Ala 
    2450                 2455                 2460             


Arg Met  Thr Leu Ala Lys Ala  Cys Glu Leu Cys Pro  Glu Glu Glu 
    2465                 2470                 2475             


Pro Asp  Asp Gln Asp Ala Pro  Asp Glu His Glu Ser  Pro Pro Pro 
    2480                 2485                 2490             


Glu Asp  Ala Pro Leu Tyr Pro  His Ser Pro Gly Ser  Gln Tyr Gln 
    2495                 2500                 2505             


Gln Asn  Asn His Val His Gly  Gln Pro Tyr Thr Gly  Pro Ala Ala 
    2510                 2515                 2520             


His His  Met Asn Asn Pro Gln  Arg Thr Gly Gln Arg  Ala Gln Glu 
    2525                 2530                 2535             


Asn Tyr  Glu Gly Ser Glu Glu  Val Ser Pro Pro Gln  Thr Lys Asp 
    2540                 2545                 2550             


Gln 
    


<210> 239
<211> 509
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 239
Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro 
            500                 505                 


<210> 240
<211> 543
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 240
Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Arg Pro Glu Asn Thr Pro Glu Pro Val Ser Thr Ser Val Ser His Tyr 
            20                  25                  30          


Gly Ala Glu Pro Thr Thr Val Ser Pro Cys Pro Ser Ser Ser Ala Lys 
        35                  40                  45              


Gly Thr Ala Val Asn Phe Ser Ser Leu Ser Met Thr Pro Phe Gly Gly 
    50                  55                  60                  


Ser Ser Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val 
65                  70                  75                  80  


Val Pro Ser Ser Tyr Pro Ala Gly Leu Thr Gly Gly Val Thr Ile Phe 
                85                  90                  95      


Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe 
            100                 105                 110         


Lys Lys Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp 
        115                 120                 125             


Trp Glu Ala Arg Ser Ile Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser 
    130                 135                 140                 


Asn Tyr Val Ala Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe 
145                 150                 155                 160 


Gly Lys Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly 
                165                 170                 175     


Asn Gln Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly 
            180                 185                 190         


Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn 
        195                 200                 205             


Val Lys His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile 
    210                 215                 220                 


Thr Thr Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr 
225                 230                 235                 240 


Thr Glu His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro 
                245                 250                 255     


Thr Val Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile 
            260                 265                 270         


Pro Arg Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe 
        275                 280                 285             


Gly Glu Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile 
    290                 295                 300                 


Lys Thr Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu 
305                 310                 315                 320 


Ala Gln Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr 
                325                 330                 335     


Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser 
            340                 345                 350         


Lys Gly Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu 
        355                 360                 365             


Lys Leu Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met 
    370                 375                 380                 


Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
385                 390                 395                 400 


Asn Ile Leu Val Gly Glu Asn Leu Val Cys Lys Ile Ala Asp Phe Gly 
                405                 410                 415     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala 
            420                 425                 430         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg 
        435                 440                 445             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu 
    450                 455                 460                 


Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu 
465                 470                 475                 480 


Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly 
                485                 490                 495     


Cys Pro Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp 
            500                 505                 510         


Pro Asp Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp 
        515                 520                 525             


Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535                 540             


<210> 241
<211> 403
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 241
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Val Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210> 242
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 242
Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210> 243
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 243
Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210> 244
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 244
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 245
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 245
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 246
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 246
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 247
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 247
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 248
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 248
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Arg Tyr 
            20                  25                  30          


Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 249
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 249
Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
            20                  25                  30          


Phe Tyr His Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Tyr Val Ser Tyr 
65                  70                  75                  80  


Pro Glu Tyr Tyr Phe Pro Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95  


<210> 250
<211> 98
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 250
Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
            20                  25                  30          


Tyr Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Trp Tyr Tyr Tyr 
65                  70                  75                  80  


Asp Asp Glu Tyr Tyr Met Asn Glu Ser Ser Pro Ile Ser Ile Asn Tyr 
                85                  90                  95      


Arg Thr 
        


<210> 251
<211> 93
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 251
Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Val 
            20                  25                  30          


His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Ile Asp Phe Tyr 
65                  70                  75                  80  


Trp Gly Ser Tyr Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90              


<210> 252
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 252
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 253
<211> 195
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 253
Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln Asp Lys 
1               5                   10                  15      


Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro Asp Gly 
            20                  25                  30          


Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp Gln Ser 
        35                  40                  45              


Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala Asp His 
    50                  55                  60                  


Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu Phe Ile 
65                  70                  75                  80  


Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu Leu Leu 
                85                  90                  95      


Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr Gly Gly 
            100                 105                 110         


Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu Gly Pro 
        115                 120                 125             


Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser Asn Gly 
    130                 135                 140                 


His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu Tyr Asp 
145                 150                 155                 160 


Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu Glu Leu 
                165                 170                 175     


Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu Gln Asn 
            180                 185                 190         


Ala Cys Ser 
        195 


<210> 254
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 254
Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys Asn Arg Met Lys 
1               5                   10                  15      


Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly Val Val Glu Gly 
            20                  25                  30          


Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly Gly Asp Ile Ala 
        35                  40                  45              


Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn Arg Pro Ser Ala 
    50                  55                  60                  


Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile Arg Phe Gln Arg 
65                  70                  75                  80  


Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser Gln Gln Ala Ala 
                85                  90                  95      


Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr Glu Gln Ile Arg 
            100                 105                 110         


Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly Asp Phe Ala Cys 
        115                 120                 125             


Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro Ala Asp Ile Glu 
    130                 135                 140                 


Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp Glu Val Leu Asp 
145                 150                 155                 160 


Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro Ile Ile Asn Trp 
                165                 170                 175     


Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu Tyr Ala Leu Trp 
            180                 185                 190         


Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val Leu Gln Ala Thr 
        195                 200                 205             


Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys Ala Leu His Asp 
    210                 215                 220                 


Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg Trp Lys Asp Trp 
225                 230                 235                 240 


Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe Ser Leu Arg Glu 
                245                 250                 255     


Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser Leu Ala Ser Gln 
            260                 265                 270         


Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val Leu Ala His Ile 
        275                 280                 285             


Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr Tyr Lys Ser Phe 
    290                 295                 300                 


Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly Val Tyr Leu Pro 
305                 310                 315                 320 


Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro Ile Ala Leu Gly 
                325                 330                 335     


Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met Glu Asn Asp Gly 
            340                 345                 350         


Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr Asp Asp Asp Val 
        355                 360                 365             


Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg Lys Leu Leu His 
    370                 375                 380                 


Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu Glu Gln Gln Glu 
385                 390                 395                 400 


Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr Glu Gly Gly Val 
                405                 410                 415     


Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn His Pro Leu Val 
            420                 425                 430         


Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg Gln Ile Arg Pro 
        435                 440                 445             


Cys Thr Ser Leu Ser 
    450             


<210> 255
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 255
Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly Ser Gly His 
1               5                   10                  15      


Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn Ala Val Leu 
            20                  25                  30          


Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys Leu Arg Arg 
        35                  40                  45              


Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln Glu Leu Thr 
    50                  55                  60                  


Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro Asp Ser Cys 
65                  70                  75                  80  


Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln Lys Tyr Val 
                85                  90                  95      


Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe Leu Lys 
            100                 105                 110         


Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg Gly Arg Arg 
        115                 120                 125             


Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro Pro Arg Arg 
    130                 135                 140                 


Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp Asp Arg Ala 
145                 150                 155                 160 


Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser Lys Ile Val 
                165                 170                 175     


Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys Gln Ala Cys 
            180                 185                 190         


Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu Ser Leu Pro 
        195                 200                 205             


Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu Arg Asp Cys 
    210                 215                 220                 


Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu Asn Ala Pro 
225                 230                 235                 240 


Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys Lys Leu Thr 
                245                 250                 255     


Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn Arg Phe Ser 
            260                 265                 270         


Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val Asp Phe Pro 
        275                 280                 285             


Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys Ala Gly Ser 
    290                 295                 300                 


Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly Ser Val His 
305                 310                 315                 320 


Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly Trp His Val 
                325                 330                 335     


Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln Val Ala Ser 
            340                 345                 350         


Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu Pro Pro Arg 
        355                 360                 365             


Cys Leu 
    370 


<210> 256
<211> 175
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 256
Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu Gly Leu Tyr Arg Lys 
1               5                   10                  15      


Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg Ala Val Ala Glu Gln 
            20                  25                  30          


Val Leu His Ser Gln Ser Arg His Val Glu Val Arg Met Ala Cys Ile 
        35                  40                  45              


His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala Phe Ile Glu Gly 
    50                  55                  60                  


Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro Gln Glu Trp Val 
65                  70                  75                  80  


Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr Arg Lys Asp Phe 
                85                  90                  95      


Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln Val Thr Glu Asn 
            100                 105                 110         


Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn Gly Asn His Tyr 
        115                 120                 125             


Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser Ala Met Cys Gln 
    130                 135                 140                 


Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe Lys Thr Asp Val 
145                 150                 155                 160 


Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val Ala Asp Glu 
                165                 170                 175 


<210> 257
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 257
Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser 
1               5                   10                  15      


Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys 
            20                  25                  30          


Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His 
        35                  40                  45              


Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala 
    50                  55                  60                  


Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val 
65                  70                  75                  80  


Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr 
                85                  90                  95      


Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln 
            100                 105                 110         


Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala 
        115                 120                 125             


Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly 
145                 150                 155                 160 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser 
                165                 170                 175     


Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala 
            180                 185                 190         


Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr 
        195                 200                 205             


Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys 
    210                 215                 220                 


Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr 
                245                 250                 255     


Gln Gln Gln Asp Ala His Glu Phe Met Arg Tyr Leu Leu Asp His Leu 
            260                 265                 270         


His Leu Glu Leu Gln Gly Gly Phe Asn Gly Val Ser Arg Ser Ala Ile 
        275                 280                 285             


Leu Gln Glu Asn Ser Thr Leu Ser Ala Ser Asn Lys Cys Cys Ile Asn 
    290                 295                 300                 


Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln Asn 
305                 310                 315                 320 


Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys Arg 
            340                 345                 350         


Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu 
        355                 360                 365             


Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met 
    370                 375                 380                 


Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp Ile 
385                 390                 395                 400 


Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp 
                405                 410                 415     


Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu 
            420                 425                 430         


Arg Gly Leu Asp Met Lys Cys Tyr Leu Leu Glu Pro Glu Asn Ser Gly 
        435                 440                 445             


Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly 
    450                 455                 460                 


Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly 
465                 470                 475                 480 


Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu 
                485                 490                 495     


Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His Gln 
            500                 505                 510         


Ala Lys Ala Gly Ser Asp Lys Leu 
        515                 520 


<210> 258
<211> 1005
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 258
Met Gly Cys Gly Cys Ser Ser His Pro Glu Asp Asp Trp Met Glu Asn 
1               5                   10                  15      


Ile Asp Val Cys Glu Asn Cys His Tyr Pro Ile Val Pro Leu Asp Gly 
            20                  25                  30          


Lys Gly Thr Leu Leu Ile Arg Asn Gly Ser Glu Val Arg Asp Pro Leu 
        35                  40                  45              


Val Thr Tyr Glu Gly Ser Asn Pro Pro Ala Ser Pro Leu Gln Asp Asn 
    50                  55                  60                  


Leu Val Ile Ala Leu His Ser Tyr Glu Pro Ser His Asp Gly Asp Leu 
65                  70                  75                  80  


Gly Phe Glu Lys Gly Glu Gln Leu Arg Ile Leu Glu Gln Ser Gly Glu 
                85                  90                  95      


Trp Trp Lys Ala Gln Ser Leu Thr Thr Gly Gln Glu Gly Phe Ile Pro 
            100                 105                 110         


Phe Asn Phe Val Ala Lys Ala Asn Ser Leu Glu Pro Glu Pro Trp Phe 
        115                 120                 125             


Phe Lys Asn Leu Ser Arg Lys Asp Ala Glu Arg Gln Leu Leu Ala Pro 
    130                 135                 140                 


Gly Asn Thr His Gly Ser Phe Leu Ile Arg Glu Ser Glu Ser Thr Ala 
145                 150                 155                 160 


Gly Ser Phe Ser Leu Ser Val Arg Asp Phe Asp Gln Asn Gln Gly Glu 
                165                 170                 175     


Val Val Lys His Tyr Lys Ile Arg Asn Leu Asp Asn Gly Gly Phe Tyr 
            180                 185                 190         


Ile Ser Pro Arg Ile Thr Phe Pro Gly Leu His Glu Leu Val Arg His 
        195                 200                 205             


Tyr Thr Asn Ala Ser Asp Gly Leu Cys Thr Arg Leu Ser Arg Pro Cys 
    210                 215                 220                 


Gln Thr Gln Lys Pro Gln Lys Pro Trp Trp Glu Asp Glu Trp Glu Val 
225                 230                 235                 240 


Pro Arg Glu Thr Leu Lys Leu Val Glu Arg Leu Gly Ala Gly Gln Phe 
                245                 250                 255     


Gly Glu Val Trp Met Gly Tyr Tyr Asn Gly His Thr Lys Val Ala Val 
            260                 265                 270         


Lys Ser Leu Lys Gln Gly Ser Met Ser Pro Asp Ala Phe Leu Ala Glu 
        275                 280                 285             


Ala Asn Leu Met Lys Gln Leu Gln His Gln Arg Leu Val Arg Leu Tyr 
    290                 295                 300                 


Ala Val Val Thr Gln Glu Pro Ile Tyr Ile Ile Thr Glu Tyr Met Glu 
305                 310                 315                 320 


Asn Gly Ser Leu Val Asp Phe Leu Lys Thr Pro Ser Gly Ile Lys Leu 
                325                 330                 335     


Thr Ile Asn Lys Leu Leu Asp Met Ala Ala Gln Ile Ala Glu Gly Met 
            340                 345                 350         


Ala Phe Ile Glu Glu Arg Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
        355                 360                 365             


Asn Ile Leu Val Ser Asp Thr Leu Ser Cys Lys Ile Ala Asp Phe Gly 
    370                 375                 380                 


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Glu Gly Ala 
385                 390                 395                 400 


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ile Asn Tyr Gly Thr 
                405                 410                 415     


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Thr Glu 
            420                 425                 430         


Ile Val Thr His Gly Arg Ile Pro Tyr Pro Gly Met Thr Asn Pro Glu 
        435                 440                 445             


Val Ile Gln Asn Leu Glu Arg Gly Tyr Arg Met Val Arg Pro Asp Asn 
    450                 455                 460                 


Cys Pro Glu Glu Leu Tyr Gln Leu Met Arg Leu Cys Trp Lys Glu Arg 
465                 470                 475                 480 


Pro Glu Asp Arg Pro Thr Phe Asp Tyr Leu Arg Ser Val Leu Glu Asp 
                485                 490                 495     


Phe Phe Thr Ala Thr Glu Gly Gln Tyr Gln Pro Gln Pro Val Ser Lys 
            500                 505                 510         


Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp 
        515                 520                 525             


Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly 
    530                 535                 540                 


Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly 
545                 550                 555                 560 


Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly 
                565                 570                 575     


Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe 
            580                 585                 590         


Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe 
        595                 600                 605             


Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu 
    610                 615                 620                 


Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys 
625                 630                 635                 640 


Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser 
                645                 650                 655     


His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val 
            660                 665                 670         


Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala 
        675                 680                 685             


Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu 
    690                 695                 700                 


Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro 
705                 710                 715                 720 


Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala 
                725                 730                 735     


Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Ser Gly Ala Thr 
            740                 745                 750         


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
        755                 760                 765             


Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu 
    770                 775                 780                 


Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu 
785                 790                 795                 800 


Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln 
                805                 810                 815     


Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp 
            820                 825                 830         


Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys 
        835                 840                 845             


His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly 
    850                 855                 860                 


Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr 
865                 870                 875                 880 


Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val 
                885                 890                 895     


Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys 
            900                 905                 910         


Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp 
        915                 920                 925             


Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly 
    930                 935                 940                 


Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro 
945                 950                 955                 960 


Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr 
                965                 970                 975     


Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu 
            980                 985                 990         


Gly Arg His Ser Thr Gly Gly Met  Asp Glu Leu Tyr Lys  
        995                 1000                 1005 


<210> 259
<211> 1039
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 259
Met Gly Cys Ile Lys Ser Lys Glu Asn Lys Ser Pro Ala Ile Lys Tyr 
1               5                   10                  15      


Arg Pro Glu Asn Thr Pro Glu Pro Val Ser Thr Ser Val Ser His Tyr 
            20                  25                  30          


Gly Ala Glu Pro Thr Thr Val Ser Pro Cys Pro Ser Ser Ser Ala Lys 
        35                  40                  45              


Gly Thr Ala Val Asn Phe Ser Ser Leu Ser Met Thr Pro Phe Gly Gly 
    50                  55                  60                  


Ser Ser Gly Val Thr Pro Phe Gly Gly Ala Ser Ser Ser Phe Ser Val 
65                  70                  75                  80  


Val Pro Ser Ser Tyr Pro Ala Gly Leu Thr Gly Gly Val Thr Ile Phe 
                85                  90                  95      


Val Ala Leu Tyr Asp Tyr Glu Ala Arg Thr Thr Glu Asp Leu Ser Phe 
            100                 105                 110         


Lys Lys Gly Glu Arg Phe Gln Ile Ile Asn Asn Thr Glu Gly Asp Trp 
        115                 120                 125             


Trp Glu Ala Arg Ser Ile Ala Thr Gly Lys Asn Gly Tyr Ile Pro Ser 
    130                 135                 140                 


Asn Tyr Val Ala Pro Ala Asp Ser Ile Gln Ala Glu Glu Trp Tyr Phe 
145                 150                 155                 160 


Gly Lys Met Gly Arg Lys Asp Ala Glu Arg Leu Leu Leu Asn Pro Gly 
                165                 170                 175     


Asn Gln Arg Gly Ile Phe Leu Val Arg Glu Ser Glu Thr Thr Lys Gly 
            180                 185                 190         


Ala Tyr Ser Leu Ser Ile Arg Asp Trp Asp Glu Ile Arg Gly Asp Asn 
        195                 200                 205             


Val Lys His Tyr Lys Ile Arg Lys Leu Asp Asn Gly Gly Tyr Tyr Ile 
    210                 215                 220                 


Thr Thr Arg Ala Gln Phe Asp Thr Leu Gln Lys Leu Val Lys His Tyr 
225                 230                 235                 240 


Thr Glu His Ala Asp Gly Leu Cys His Lys Leu Thr Thr Val Cys Pro 
                245                 250                 255     


Thr Val Lys Pro Gln Thr Gln Gly Leu Ala Lys Asp Ala Trp Glu Ile 
            260                 265                 270         


Pro Arg Glu Ser Leu Arg Leu Glu Val Lys Leu Gly Gln Gly Cys Phe 
        275                 280                 285             


Gly Glu Val Trp Met Gly Thr Trp Asn Gly Thr Thr Lys Val Ala Ile 
    290                 295                 300                 


Lys Thr Leu Lys Pro Gly Thr Met Met Pro Glu Ala Phe Leu Gln Glu 
305                 310                 315                 320 


Ala Gln Ile Met Lys Lys Leu Arg His Asp Lys Leu Val Pro Leu Tyr 
                325                 330                 335     


Ala Val Val Ser Glu Glu Pro Ile Tyr Ile Val Thr Glu Phe Met Ser 
            340                 345                 350         


Lys Gly Ser Leu Leu Asp Phe Leu Lys Glu Gly Asp Gly Lys Tyr Leu 
        355                 360                 365             


Lys Leu Pro Gln Leu Val Asp Met Ala Ala Gln Ile Ala Asp Gly Met 
    370                 375                 380                 


Ala Tyr Ile Glu Arg Met Asn Tyr Ile His Arg Asp Leu Arg Ala Ala 
385                 390                 395                 400 


Asn Ile Leu Val Gly Glu Asn Leu Val Cys Lys Ile Ala Asp Phe Gly 
                405                 410                 415     


Leu Ala Arg Leu Ile Glu Asp Asn Glu Tyr Thr Ala Arg Gln Gly Ala 
            420                 425                 430         


Lys Phe Pro Ile Lys Trp Thr Ala Pro Glu Ala Ala Leu Tyr Gly Arg 
        435                 440                 445             


Phe Thr Ile Lys Ser Asp Val Trp Ser Phe Gly Ile Leu Gln Thr Glu 
    450                 455                 460                 


Leu Val Thr Lys Gly Arg Val Pro Tyr Pro Gly Met Val Asn Arg Glu 
465                 470                 475                 480 


Val Leu Glu Gln Val Glu Arg Gly Tyr Arg Met Pro Cys Pro Gln Gly 
                485                 490                 495     


Cys Pro Glu Ser Leu His Glu Leu Met Asn Leu Cys Trp Lys Lys Asp 
            500                 505                 510         


Pro Asp Glu Arg Pro Thr Phe Glu Tyr Ile Gln Ser Phe Leu Glu Asp 
        515                 520                 525             


Tyr Phe Thr Ala Thr Glu Pro Gln Tyr Gln Pro Gly Glu Asn Leu Val 
    530                 535                 540                 


Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
545                 550                 555                 560 


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
                565                 570                 575     


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
            580                 585                 590         


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly 
        595                 600                 605             


Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His 
    610                 615                 620                 


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
625                 630                 635                 640 


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
                645                 650                 655     


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
            660                 665                 670         


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
        675                 680                 685             


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
    690                 695                 700                 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
705                 710                 715                 720 


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
                725                 730                 735     


Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys 
            740                 745                 750         


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
        755                 760                 765             


Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Ser Gly 
    770                 775                 780                 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
785                 790                 795                 800 


Pro Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile 
                805                 810                 815     


Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly 
            820                 825                 830         


His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly 
        835                 840                 845             


Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe 
    850                 855                 860                 


Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr 
865                 870                 875                 880 


Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro 
                885                 890                 895     


Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val 
            900                 905                 910         


Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr 
        915                 920                 925             


Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met 
    930                 935                 940                 


Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro 
945                 950                 955                 960 


Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys 
                965                 970                 975     


Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys 
            980                 985                 990         


Lys Pro Val Gln Leu Pro Gly Ala  Tyr Asn Val Asn Ile  Lys Leu Asp 
        995                 1000                 1005             


Ile Thr  Ser His Asn Glu Asp  Tyr Thr Ile Val Glu  Gln Tyr Glu 
    1010                 1015                 1020             


Arg Ala  Glu Gly Arg His Ser  Thr Gly Gly Met Asp  Glu Leu Tyr 
    1025                 1030                 1035             


Lys 
    


<210> 260
<211> 899
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 260
Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Val Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro 
                405                 410                 415     


Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val 
            420                 425                 430         


Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys 
        435                 440                 445             


Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val 
    450                 455                 460                 


Thr Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His 
465                 470                 475                 480 


Met Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val 
                485                 490                 495     


Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg 
            500                 505                 510         


Ala Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu 
        515                 520                 525             


Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu 
    530                 535                 540                 


Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln 
545                 550                 555                 560 


Lys Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp 
                565                 570                 575     


Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly 
            580                 585                 590         


Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser 
        595                 600                 605             


Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu 
    610                 615                 620                 


Glu Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr 
625                 630                 635                 640 


Lys Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
                645                 650                 655     


Val Glu Glu Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn 
            660                 665                 670         


Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly 
        675                 680                 685             


Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg 
    690                 695                 700                 


Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly 
705                 710                 715                 720 


Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly 
                725                 730                 735     


Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys 
            740                 745                 750         


Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu 
        755                 760                 765             


Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly 
    770                 775                 780                 


Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp 
785                 790                 795                 800 


Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu 
                805                 810                 815     


Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg 
            820                 825                 830         


Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr 
        835                 840                 845             


Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn 
    850                 855                 860                 


Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu 
865                 870                 875                 880 


Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu 
                885                 890                 895     


Leu Tyr Lys 
            


<210> 261
<211> 655
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 261
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser 
            260                 265                 270         


Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro 
        275                 280                 285             


Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu 
    290                 295                 300                 


Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg 
305                 310                 315                 320 


Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro 
                325                 330                 335     


Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr 
            340                 345                 350         


Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser 
        355                 360                 365             


Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser 
    370                 375                 380                 


Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp 
385                 390                 395                 400 


Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His 
                405                 410                 415     


Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys 
            420                 425                 430         


Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr 
        435                 440                 445             


Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln 
    450                 455                 460                 


Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met 
465                 470                 475                 480 


His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu 
                485                 490                 495     


Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala 
            500                 505                 510         


His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg 
        515                 520                 525             


Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr 
    530                 535                 540                 


Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val 
545                 550                 555                 560 


Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln 
                565                 570                 575     


Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu 
            580                 585                 590         


Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp 
        595                 600                 605             


Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile 
    610                 615                 620                 


Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val 
625                 630                 635                 640 


Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                645                 650                 655 


<210> 262
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 262
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val 
            260                 265                 270         


Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His 
        275                 280                 285             


Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val 
    290                 295                 300                 


Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His 
305                 310                 315                 320 


Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp 
                325                 330                 335     


Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly 
            340                 345                 350         


Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His 
        355                 360                 365             


Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile 
    370                 375                 380                 


His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser 
385                 390                 395                 400 


Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro 
                405                 410                 415     


Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys 
            420                 425                 430         


Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met 
        435                 440                 445             


Tyr Ile Glu Gln Asn Ala Cys Ser 
    450                 455     


<210> 263
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 263
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile 
            260                 265                 270         


Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val 
        275                 280                 285             


Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser 
    290                 295                 300                 


Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu 
305                 310                 315                 320 


Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala 
                325                 330                 335     


Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val 
            340                 345                 350         


Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu 
        355                 360                 365             


Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys 
    370                 375                 380                 


Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu 
385                 390                 395                 400 


Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe 
                405                 410                 415     


Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser 
            420                 425                 430         


Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg 
        435                 440                 445             


Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser 
    450                 455                 460                 


Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg 
465                 470                 475                 480 


Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr 
                485                 490                 495     


Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His 
            500                 505                 510         


Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu 
        515                 520                 525             


Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe 
    530                 535                 540                 


Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys 
545                 550                 555                 560 


Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln 
                565                 570                 575     


Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser 
            580                 585                 590         


Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala 
        595                 600                 605             


Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn 
    610                 615                 620                 


Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu 
625                 630                 635                 640 


Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn 
                645                 650                 655     


Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val 
            660                 665                 670         


Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg 
        675                 680                 685             


Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr 
    690                 695                 700                 


Arg Gln Ile Arg Pro Cys Thr Ser Leu Ser 
705                 710                 


<210> 264
<211> 631
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 264
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ser Asp Asp Lys Met Ala His His Thr Leu Leu 
            260                 265                 270         


Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
        275                 280                 285             


Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp 
    290                 295                 300                 


Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg 
305                 310                 315                 320 


Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp 
                325                 330                 335     


His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val 
            340                 345                 350         


Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala 
        355                 360                 365             


Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn 
    370                 375                 380                 


Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro 
385                 390                 395                 400 


Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser 
                405                 410                 415     


Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu 
            420                 425                 430         


Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu 
        435                 440                 445             


Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys 
    450                 455                 460                 


Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val 
465                 470                 475                 480 


Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu 
                485                 490                 495     


Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser 
            500                 505                 510         


Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His 
        515                 520                 525             


Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val 
    530                 535                 540                 


Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser 
545                 550                 555                 560 


Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His 
                565                 570                 575     


Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln 
            580                 585                 590         


Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu 
        595                 600                 605             


Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met 
    610                 615                 620                 


Gln Glu Pro Pro Arg Cys Leu 
625                 630     


<210> 265
<211> 436
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 265
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            260                 265                 270         


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        275                 280                 285             


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    290                 295                 300                 


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
305                 310                 315                 320 


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                325                 330                 335     


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            340                 345                 350         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        355                 360                 365             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    370                 375                 380                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser 
385                 390                 395                 400 


Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val 
                405                 410                 415     


Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu 
            420                 425                 430         


Val Ala Asp Glu 
        435     


<210> 266
<211> 770
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 266
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser 
    370                 375                 380                 


Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr 
385                 390                 395                 400 


Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu 
                405                 410                 415     


Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser 
            420                 425                 430         


Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn 
        435                 440                 445             


Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu 
    450                 455                 460                 


Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
465                 470                 475                 480 


Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
                485                 490                 495     


Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr 
            500                 505                 510         


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
        515                 520                 525             


Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu 
    530                 535                 540                 


Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp 
545                 550                 555                 560 


Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp 
                565                 570                 575     


Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu 
            580                 585                 590         


Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu 
        595                 600                 605             


Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe 
    610                 615                 620                 


Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr 
625                 630                 635                 640 


Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly 
                645                 650                 655     


Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser 
            660                 665                 670         


Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser 
        675                 680                 685             


Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr 
    690                 695                 700                 


Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly 
705                 710                 715                 720 


Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala 
                725                 730                 735     


Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr 
            740                 745                 750         


Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu 
        755                 760                 765             


Ala Gln 
    770 


<210> 267
<211> 571
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 267
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Asp Glu Lys Leu Ala Leu Tyr Leu 
    370                 375                 380                 


Ala Glu Val Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr 
385                 390                 395                 400 


Arg Phe His Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser 
                405                 410                 415     


Lys Thr Val Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln 
            420                 425                 430         


Thr Val His Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile 
        435                 440                 445             


Glu Gly Asp Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala 
    450                 455                 460                 


Trp Ala Gly Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val 
465                 470                 475                 480 


Asn Ile His Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser 
                485                 490                 495     


Thr Met Ile His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile 
            500                 505                 510         


Trp Leu Ser Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His 
        515                 520                 525             


Ser Tyr Pro Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val 
    530                 535                 540                 


Gln Arg Lys Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu 
545                 550                 555                 560 


Ser Lys Met Tyr Ile Glu Gln Asn Ala Cys Ser 
                565                 570     


<210> 268
<211> 828
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 268
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Leu Glu Val Asp Phe Lys Lys Leu 
    370                 375                 380                 


Lys Gln Ile Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn 
385                 390                 395                 400 


Ala Cys Val Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr 
                405                 410                 415     


Lys Ser Ser Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val 
            420                 425                 430         


Arg Leu Leu Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val 
        435                 440                 445             


His Leu Ala Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu 
    450                 455                 460                 


Thr Glu Val Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys 
465                 470                 475                 480 


Pro Glu Leu Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His 
                485                 490                 495     


Gln Arg Lys Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr 
            500                 505                 510         


Phe Thr Leu Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu 
        515                 520                 525             


Lys Leu Phe Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu 
    530                 535                 540                 


Glu Glu Ser Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu 
545                 550                 555                 560 


Asp Ser Arg Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu 
                565                 570                 575     


Leu Asp Ser Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser 
            580                 585                 590         


Val Leu Arg Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp 
        595                 600                 605             


Phe Tyr Thr Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe 
    610                 615                 620                 


Gly Leu His Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala 
625                 630                 635                 640 


Phe Ile Leu Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr 
                645                 650                 655     


His Ile Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr 
            660                 665                 670         


Gly Val Lys Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr 
        675                 680                 685             


Arg Phe Gln Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys 
    690                 695                 700                 


Trp Lys Ser Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala 
705                 710                 715                 720 


Leu Val Ala Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala 
                725                 730                 735     


Asn Leu Asn Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val 
            740                 745                 750         


Asp Ser Glu Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu 
        755                 760                 765             


Leu Gly Asn Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp 
    770                 775                 780                 


Cys Cys Val Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser 
785                 790                 795                 800 


Arg Arg Arg Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu 
                805                 810                 815     


Asp Arg Tyr Arg Gln Ile Arg Pro Cys Thr Ser Leu 
            820                 825             


<210> 269
<211> 746
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 269
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Ser Asp Asp Lys Met Ala His His 
    370                 375                 380                 


Thr Leu Leu Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn 
385                 390                 395                 400 


Thr Cys Phe Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro 
                405                 410                 415     


Leu Arg Asp Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly 
            420                 425                 430         


Gly Gly Arg Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly 
        435                 440                 445             


Ala Leu Trp His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe 
    450                 455                 460                 


Arg Ala Val Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln 
465                 470                 475                 480 


Gln Asp Ala Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu 
                485                 490                 495     


Glu Ile Asn Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly 
            500                 505                 510         


Pro Val Pro Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro 
        515                 520                 525             


Glu Leu Ser Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu 
    530                 535                 540                 


Glu Arg Glu Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys 
545                 550                 555                 560 


Ser Cys Leu Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu 
                565                 570                 575     


Val Phe Cys Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly 
            580                 585                 590         


Gly Lys Val Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu 
        595                 600                 605             


Glu Leu Glu Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys 
    610                 615                 620                 


Thr Arg Ser Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu 
625                 630                 635                 640 


Val Leu His Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys 
                645                 650                 655     


Ser Ser Val Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp 
            660                 665                 670         


Phe Ala Ser Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu 
        675                 680                 685             


Cys Asn His Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys 
    690                 695                 700                 


Arg Cys Gln Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro 
705                 710                 715                 720 


Val Ser Glu Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr 
                725                 730                 735     


Gln Leu Met Gln Glu Pro Pro Arg Cys Leu 
            740                 745     


<210> 270
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 270
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Ala Thr Pro Met Asp Ala Tyr Leu 
    370                 375                 380                 


Arg Lys Leu Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys 
385                 390                 395                 400 


Leu Phe Arg Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His 
                405                 410                 415     


Val Glu Val Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu 
            420                 425                 430         


Lys Phe Glu Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg 
        435                 440                 445             


Leu Glu Asn Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu 
    450                 455                 460                 


Ser Leu Met Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val 
465                 470                 475                 480 


Ser Pro Ser Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu 
                485                 490                 495     


Cys Phe Ser Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr 
            500                 505                 510         


Lys Glu Ser Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr 
        515                 520                 525             


Glu Lys Val Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp 
    530                 535                 540                 


Thr Leu Glu Val Ala Asp Glu 
545                 550     


<210> 271
<211> 750
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 271
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Leu Tyr Tyr Leu Ile Thr Tyr Gly Glu Thr Gly Asp 
    290                 295                 300                 


His Trp Ser Gly His Gln Ala Phe Glu Val Pro Gly Ser Lys Ser Thr 
305                 310                 315                 320 


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
                325                 330                 335     


Tyr Ala His Ala Glu Ser Tyr Gly Glu Ser Tyr Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
        355                 360                 365             


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
    370                 375                 380                 


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
385                 390                 395                 400 


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
                405                 410                 415     


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
            420                 425                 430         


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
        435                 440                 445             


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
    450                 455                 460                 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
465                 470                 475                 480 


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
                485                 490                 495     


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
            500                 505                 510         


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
        515                 520                 525             


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
    530                 535                 540                 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
545                 550                 555                 560 


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
                565                 570                 575     


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
            580                 585                 590         


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
        595                 600                 605             


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
    610                 615                 620                 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
625                 630                 635                 640 


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
                645                 650                 655     


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys 
            660                 665                 670         


Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr 
        675                 680                 685             


Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu 
    690                 695                 700                 


Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu 
705                 710                 715                 720 


Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys 
                725                 730                 735     


Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            740                 745                 750 


<210> 272
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 272
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Leu Tyr Tyr Leu Ile Thr Tyr Gly Glu Thr Gly Asp 
    290                 295                 300                 


His Trp Ser Gly His Gln Ala Phe Glu Val Pro Gly Ser Lys Ser Thr 
305                 310                 315                 320 


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
                325                 330                 335     


Tyr Ala His Ala Glu Ser Tyr Gly Glu Ser Tyr Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu 
        355                 360                 365             


Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile 
    370                 375                 380                 


Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr 
385                 390                 395                 400 


Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr 
                405                 410                 415     


Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val 
            420                 425                 430         


Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr 
        435                 440                 445             


Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu 
    450                 455                 460                 


Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His 
465                 470                 475                 480 


Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp 
                485                 490                 495     


Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro Asn 
            500                 505                 510         


Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys Arg 
        515                 520                 525             


Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met Tyr 
    530                 535                 540                 


Ile Glu Gln Asn Ala Cys Ser 
545                 550     


<210> 273
<211> 809
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 273
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Leu Tyr Tyr Leu Ile Thr Tyr Gly Glu Thr Gly Asp 
    290                 295                 300                 


His Trp Ser Gly His Gln Ala Phe Glu Val Pro Gly Ser Lys Ser Thr 
305                 310                 315                 320 


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
                325                 330                 335     


Tyr Ala His Ala Glu Ser Tyr Gly Glu Ser Tyr Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
        355                 360                 365             


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
    370                 375                 380                 


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
385                 390                 395                 400 


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
                405                 410                 415     


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
            420                 425                 430         


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
        435                 440                 445             


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
    450                 455                 460                 


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
465                 470                 475                 480 


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
                485                 490                 495     


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
            500                 505                 510         


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
        515                 520                 525             


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
    530                 535                 540                 


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
545                 550                 555                 560 


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
                565                 570                 575     


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
            580                 585                 590         


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
        595                 600                 605             


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
    610                 615                 620                 


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
625                 630                 635                 640 


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
                645                 650                 655     


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
            660                 665                 670         


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
        675                 680                 685             


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met 
    690                 695                 700                 


Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr 
705                 710                 715                 720 


Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg 
                725                 730                 735     


Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu 
            740                 745                 750         


Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr 
        755                 760                 765             


Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn 
    770                 775                 780                 


His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg 
785                 790                 795                 800 


Gln Ile Arg Pro Cys Thr Ser Leu Ser 
                805                 


<210> 274
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 274
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Gly Ser Val Ser Ser Val Pro Thr Lys Leu 
                245                 250                 255     


Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala 
            260                 265                 270         


Pro Ala Val Thr Val Leu Tyr Tyr Leu Ile Thr Tyr Gly Glu Thr Gly 
        275                 280                 285             


Asp His Trp Ser Gly His Gln Ala Phe Glu Val Pro Gly Ser Lys Ser 
    290                 295                 300                 


Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 
305                 310                 315                 320 


Val Tyr Ala His Ala Glu Ser Tyr Gly Glu Ser Tyr Ser Pro Ile Ser 
                325                 330                 335     


Ile Asn Tyr Arg Thr Ser Asp Asp Lys Met Ala His His Thr Leu Leu 
            340                 345                 350         


Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
        355                 360                 365             


Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp 
    370                 375                 380                 


Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg 
385                 390                 395                 400 


Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp 
                405                 410                 415     


His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val 
            420                 425                 430         


Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala 
        435                 440                 445             


Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn 
    450                 455                 460                 


Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro 
465                 470                 475                 480 


Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser 
                485                 490                 495     


Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu 
            500                 505                 510         


Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu 
        515                 520                 525             


Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys 
    530                 535                 540                 


Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val 
545                 550                 555                 560 


Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu 
                565                 570                 575     


Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser 
            580                 585                 590         


Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His 
        595                 600                 605             


Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val 
    610                 615                 620                 


Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser 
625                 630                 635                 640 


Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His 
                645                 650                 655     


Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln 
            660                 665                 670         


Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu 
        675                 680                 685             


Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met 
    690                 695                 700                 


Gln Glu Pro Pro Arg Cys Leu 
705                 710     


<210> 275
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 275
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Leu Tyr Tyr Leu Ile Thr Tyr Gly Glu Thr Gly Asp 
    290                 295                 300                 


His Trp Ser Gly His Gln Ala Phe Glu Val Pro Gly Ser Lys Ser Thr 
305                 310                 315                 320 


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
                325                 330                 335     


Tyr Ala His Ala Glu Ser Tyr Gly Glu Ser Tyr Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu Gly 
        355                 360                 365             


Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg Ala 
    370                 375                 380                 


Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val Arg 
385                 390                 395                 400 


Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala 
                405                 410                 415     


Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro 
            420                 425                 430         


Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr 
        435                 440                 445             


Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln 
    450                 455                 460                 


Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn 
465                 470                 475                 480 


Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser 
                485                 490                 495     


Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe 
            500                 505                 510         


Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val 
        515                 520                 525             


Ala Asp Glu 
    530     


<210> 276
<211> 753
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 276
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Tyr Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Trp Tyr Tyr Tyr Asp Asp Glu Tyr Tyr Met Asn Glu Ser Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Pro Pro Ser Phe Ser Glu Gly Ser Gly 
        355                 360                 365             


Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg 
    370                 375                 380                 


Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys 
385                 390                 395                 400 


Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu 
                405                 410                 415     


Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu 
            420                 425                 430         


His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr 
        435                 440                 445             


Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu 
    450                 455                 460                 


Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp 
465                 470                 475                 480 


Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr 
                485                 490                 495     


Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly 
            500                 505                 510         


Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met 
        515                 520                 525             


Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln 
    530                 535                 540                 


Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu 
545                 550                 555                 560 


Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro 
                565                 570                 575     


Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser 
            580                 585                 590         


Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val 
        595                 600                 605             


Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met 
    610                 615                 620                 


Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly 
625                 630                 635                 640 


Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro 
                645                 650                 655     


Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met 
            660                 665                 670         


Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp 
        675                 680                 685             


Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys 
    690                 695                 700                 


Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser 
705                 710                 715                 720 


Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met 
                725                 730                 735     


Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala 
            740                 745                 750         


Gln 
    


<210> 277
<211> 554
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 277
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Tyr Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Trp Tyr Tyr Tyr Asp Asp Glu Tyr Tyr Met Asn Glu Ser Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Asp Glu Lys Leu Ala Leu Tyr Leu Ala 
        355                 360                 365             


Glu Val Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg 
    370                 375                 380                 


Phe His Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys 
385                 390                 395                 400 


Thr Val Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr 
                405                 410                 415     


Val His Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu 
            420                 425                 430         


Gly Asp Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp 
        435                 440                 445             


Ala Gly Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn 
    450                 455                 460                 


Ile His Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr 
465                 470                 475                 480 


Met Ile His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp 
                485                 490                 495     


Leu Ser Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser 
            500                 505                 510         


Tyr Pro Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln 
        515                 520                 525             


Arg Lys Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser 
    530                 535                 540                 


Lys Met Tyr Ile Glu Gln Asn Ala Cys Ser 
545                 550                 


<210> 278
<211> 812
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 278
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Tyr Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Trp Tyr Tyr Tyr Asp Asp Glu Tyr Tyr Met Asn Glu Ser Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Leu Glu Val Asp Phe Lys Lys Leu Lys 
        355                 360                 365             


Gln Ile Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala 
    370                 375                 380                 


Cys Val Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys 
385                 390                 395                 400 


Ser Ser Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg 
                405                 410                 415     


Leu Leu Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His 
            420                 425                 430         


Leu Ala Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr 
        435                 440                 445             


Glu Val Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro 
    450                 455                 460                 


Glu Leu Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln 
465                 470                 475                 480 


Arg Lys Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe 
                485                 490                 495     


Thr Leu Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys 
            500                 505                 510         


Leu Phe Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu 
        515                 520                 525             


Glu Ser Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp 
    530                 535                 540                 


Ser Arg Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu 
545                 550                 555                 560 


Asp Ser Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val 
                565                 570                 575     


Leu Arg Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe 
            580                 585                 590         


Tyr Thr Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly 
        595                 600                 605             


Leu His Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe 
    610                 615                 620                 


Ile Leu Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His 
625                 630                 635                 640 


Ile Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly 
                645                 650                 655     


Val Lys Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg 
            660                 665                 670         


Phe Gln Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp 
        675                 680                 685             


Lys Ser Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu 
    690                 695                 700                 


Val Ala Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn 
705                 710                 715                 720 


Leu Asn Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp 
                725                 730                 735     


Ser Glu Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu 
            740                 745                 750         


Gly Asn Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys 
        755                 760                 765             


Cys Val Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg 
    770                 775                 780                 


Arg Arg Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp 
785                 790                 795                 800 


Arg Tyr Arg Gln Ile Arg Pro Cys Thr Ser Leu Ser 
                805                 810         


<210> 279
<211> 729
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 279
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Tyr Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Trp Tyr Tyr Tyr Asp Asp Glu Tyr Tyr Met Asn Glu Ser Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Ser Asp Asp Lys Met Ala His His Thr 
        355                 360                 365             


Leu Leu Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr 
    370                 375                 380                 


Cys Phe Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu 
385                 390                 395                 400 


Arg Asp Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly 
                405                 410                 415     


Gly Arg Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala 
            420                 425                 430         


Leu Trp His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg 
        435                 440                 445             


Ala Val Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln 
    450                 455                 460                 


Asp Ala Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu 
465                 470                 475                 480 


Ile Asn Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro 
                485                 490                 495     


Val Pro Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu 
            500                 505                 510         


Leu Ser Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu 
        515                 520                 525             


Arg Glu Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser 
    530                 535                 540                 


Cys Leu Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val 
545                 550                 555                 560 


Phe Cys Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly 
                565                 570                 575     


Lys Val Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu 
            580                 585                 590         


Leu Glu Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr 
        595                 600                 605             


Arg Ser Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val 
    610                 615                 620                 


Leu His Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser 
625                 630                 635                 640 


Ser Val Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe 
                645                 650                 655     


Ala Ser Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys 
            660                 665                 670         


Asn His Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg 
        675                 680                 685             


Cys Gln Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val 
    690                 695                 700                 


Ser Glu Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln 
705                 710                 715                 720 


Leu Met Gln Glu Pro Pro Arg Cys Leu 
                725                 


<210> 280
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 280
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Tyr Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Trp Tyr Tyr Tyr Asp Asp Glu Tyr Tyr Met Asn Glu Ser Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Ala Thr Pro Met Asp Ala Tyr Leu Arg 
        355                 360                 365             


Lys Leu Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu 
    370                 375                 380                 


Phe Arg Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val 
385                 390                 395                 400 


Glu Val Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys 
                405                 410                 415     


Phe Glu Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu 
            420                 425                 430         


Glu Asn Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser 
        435                 440                 445             


Leu Met Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser 
    450                 455                 460                 


Pro Ser Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys 
465                 470                 475                 480 


Phe Ser Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys 
                485                 490                 495     


Glu Ser Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu 
            500                 505                 510         


Lys Val Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr 
        515                 520                 525             


Leu Glu Val Ala Asp Glu 
    530                 


<210> 281
<211> 748
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 281
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Ile Asp Phe Tyr Trp Gly Ser Tyr Ser Pro Ile Ser Ile Asn Tyr 
            340                 345                 350         


Arg Thr Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro 
        355                 360                 365             


Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile 
    370                 375                 380                 


Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly 
385                 390                 395                 400 


Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val 
                405                 410                 415     


Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met 
            420                 425                 430         


Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp 
        435                 440                 445             


Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val 
    450                 455                 460                 


Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro 
465                 470                 475                 480 


Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys 
                485                 490                 495     


Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp 
            500                 505                 510         


Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu 
        515                 520                 525             


Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn 
    530                 535                 540                 


Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp 
545                 550                 555                 560 


Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly 
                565                 570                 575     


Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val 
            580                 585                 590         


Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu 
        595                 600                 605             


Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly 
    610                 615                 620                 


Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu 
625                 630                 635                 640 


Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr 
                645                 650                 655     


Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn 
            660                 665                 670         


Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu 
        675                 680                 685             


Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly 
    690                 695                 700                 


Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu 
705                 710                 715                 720 


Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile 
                725                 730                 735     


Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            740                 745             


<210> 282
<211> 549
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 282
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Ile Asp Phe Tyr Trp Gly Ser Tyr Ser Pro Ile Ser Ile Asn Tyr 
            340                 345                 350         


Arg Thr Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln 
        355                 360                 365             


Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro 
    370                 375                 380                 


Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp 
385                 390                 395                 400 


Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala 
                405                 410                 415     


Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu 
            420                 425                 430         


Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu 
        435                 440                 445             


Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr 
    450                 455                 460                 


Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu 
465                 470                 475                 480 


Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser 
                485                 490                 495     


Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu 
            500                 505                 510         


Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu 
        515                 520                 525             


Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu 
    530                 535                 540                 


Gln Asn Ala Cys Ser 
545                 


<210> 283
<211> 807
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 283
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Ile Asp Phe Tyr Trp Gly Ser Tyr Ser Pro Ile Ser Ile Asn Tyr 
            340                 345                 350         


Arg Thr Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys Asn Arg 
        355                 360                 365             


Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly Val Val 
    370                 375                 380                 


Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly Gly Asp 
385                 390                 395                 400 


Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn Arg Pro 
                405                 410                 415     


Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile Arg Phe 
            420                 425                 430         


Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser Gln Gln 
        435                 440                 445             


Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr Glu Gln 
    450                 455                 460                 


Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly Asp Phe 
465                 470                 475                 480 


Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro Ala Asp 
                485                 490                 495     


Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp Glu Val 
            500                 505                 510         


Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro Ile Ile 
        515                 520                 525             


Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu Tyr Ala 
    530                 535                 540                 


Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val Leu Gln 
545                 550                 555                 560 


Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys Ala Leu 
                565                 570                 575     


His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg Trp Lys 
            580                 585                 590         


Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe Ser Leu 
        595                 600                 605             


Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser Leu Ala 
    610                 615                 620                 


Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val Leu Ala 
625                 630                 635                 640 


His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr Tyr Lys 
                645                 650                 655     


Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly Val Tyr 
            660                 665                 670         


Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro Ile Ala 
        675                 680                 685             


Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met Glu Asn 
    690                 695                 700                 


Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr Asp Asp 
705                 710                 715                 720 


Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg Lys Leu 
                725                 730                 735     


Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu Glu Gln 
            740                 745                 750         


Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr Glu Gly 
        755                 760                 765             


Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn His Pro 
    770                 775                 780                 


Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg Gln Ile 
785                 790                 795                 800 


Arg Pro Cys Thr Ser Leu Ser 
                805         


<210> 284
<211> 724
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 284
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Ile Asp Phe Tyr Trp Gly Ser Tyr Ser Pro Ile Ser Ile Asn Tyr 
            340                 345                 350         


Arg Thr Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly Ser 
        355                 360                 365             


Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn Ala 
    370                 375                 380                 


Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys Leu 
385                 390                 395                 400 


Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln Glu 
                405                 410                 415     


Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro Asp 
            420                 425                 430         


Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln Lys 
        435                 440                 445             


Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe 
    450                 455                 460                 


Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg Gly 
465                 470                 475                 480 


Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro Pro 
                485                 490                 495     


Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp Asp 
            500                 505                 510         


Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser Lys 
        515                 520                 525             


Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys Gln 
    530                 535                 540                 


Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu Ser 
545                 550                 555                 560 


Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu Arg 
                565                 570                 575     


Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu Asn 
            580                 585                 590         


Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys Lys 
        595                 600                 605             


Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn Arg 
    610                 615                 620                 


Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val Asp 
625                 630                 635                 640 


Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys Ala 
                645                 650                 655     


Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly Ser 
            660                 665                 670         


Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly Trp 
        675                 680                 685             


His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln Val 
    690                 695                 700                 


Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu Pro 
705                 710                 715                 720 


Pro Arg Cys Leu 
                


<210> 285
<211> 529
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 285
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Ile Asp Phe Tyr Trp Gly Ser Tyr Ser Pro Ile Ser Ile Asn Tyr 
            340                 345                 350         


Arg Thr Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu Gly Leu Tyr 
        355                 360                 365             


Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg Ala Val Ala 
    370                 375                 380                 


Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val Arg Met Ala 
385                 390                 395                 400 


Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala Phe Ile 
                405                 410                 415     


Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro Gln Glu 
            420                 425                 430         


Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr Arg Lys 
        435                 440                 445             


Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln Val Thr 
    450                 455                 460                 


Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn Gly Asn 
465                 470                 475                 480 


His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser Ala Met 
                485                 490                 495     


Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe Lys Thr 
            500                 505                 510         


Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val Ala Asp 
        515                 520                 525             


Glu 
    


<210> 286
<211> 394
<212> PRT
<213> Homo sapiens

<400> 286
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 287
<211> 97
<212> PRT
<213> Homo sapiens

<400> 287
Met Ala Ser Ser Ala Glu Leu Asp Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Ser Leu Ile Arg Thr 
            20                  25                  30          


Ile Ser Leu Gly Lys Glu Leu Gln Thr Val Pro Gln Thr Glu Val Asp 
        35                  40                  45              


Lys Ala Asn Gly Lys Gln Leu Val Glu Ile Phe Thr Ser His Ser Cys 
    50                  55                  60                  


Ser Tyr Trp Ala Gly Met Ala Ala Ile Gln Val Phe Glu Lys Met Asn 
65                  70                  75                  80  


Gln Thr His Leu Ser Gly Arg Ala Asp Glu His Cys Val Met Pro Pro 
                85                  90                  95      


Pro 
    


<210> 288
<211> 98
<212> PRT
<213> Homo sapiens

<400> 288
Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 
1               5                   10                  15      


Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 
            20                  25                  30          


Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe 
    50                  55                  60                  


Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu 
65                  70                  75                  80  


Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr 
                85                  90                  95      


Tyr Phe 
        


<210> 289
<211> 104
<212> PRT
<213> Homo sapiens

<400> 289
Met Ala Gly Lys Ala His Arg Leu Ser Ala Glu Glu Arg Asp Gln Leu 
1               5                   10                  15      


Leu Pro Asn Leu Arg Ala Val Gly Trp Asn Glu Leu Glu Gly Arg Asp 
            20                  25                  30          


Ala Ile Phe Lys Gln Phe His Phe Lys Asp Phe Asn Arg Ala Phe Gly 
        35                  40                  45              


Phe Met Thr Arg Val Ala Leu Gln Ala Glu Lys Leu Asp His His Pro 
    50                  55                  60                  


Glu Trp Phe Asn Val Tyr Asn Lys Val His Ile Thr Leu Ser Thr His 
65                  70                  75                  80  


Glu Cys Ala Gly Leu Ser Glu Arg Asp Ile Asn Leu Ala Ser Phe Ile 
                85                  90                  95      


Glu Gln Val Ala Val Ser Met Thr 
            100                 


<210> 290
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 290
Gly Phe Ser Phe Ser Asn Phe Pro 
1               5               


<210> 291
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 291
Ile Asn Gln Asp Gly Arg Asn Thr 
1               5               


<210> 292
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 292
Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser 
1               5                   10      


<210> 293
<211> 118
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 293
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210> 294
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 294
Gly Phe Thr Phe Ser Asn Tyr Arg 
1               5               


<210> 295
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 295
Ile Asp Arg Ser Gly Thr Tyr Thr 
1               5               


<210> 296
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 296
Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
1               5                   10                  15      


His 
    


<210> 297
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 297
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210> 298
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 298
Gly Phe Ile Phe Ser Ser Tyr Gln 
1               5               


<210> 299
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 299
Ile Asn Thr Gly Gly Trp Asn Thr 
1               5               


<210> 300
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 300
Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
1               5                   10                  15      


Phe Asp Ser 
            


<210> 301
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 301
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210> 302
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 302
Gly Phe Ala Phe Gly Ser Tyr Asp 
1               5               


<210> 303
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 303
Ile Thr Pro Gly Gly Gly Gly Thr 
1               5               


<210> 304
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 304
Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly 
1               5                   10          


<210> 305
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 305
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210> 306
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 306
Gly Phe Thr Phe Gly Thr His Ala 
1               5               


<210> 307
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 307
Ile Ser Ser Gly Gly Gly Gly Thr 
1               5               


<210> 308
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 308
Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn 
1               5                   10  


<210> 309
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 309
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210> 310
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 310
Glu Arg Thr Phe Gly His Tyr Ala 
1               5               


<210> 311
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 311
Ile Ser Trp Lys Gly Gly Thr Thr 
1               5               


<210> 312
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 312
Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
1               5                   10                  15      


Tyr 
    


<210> 313
<211> 124
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 313
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210> 314
<211> 256
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 314
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe Pro Met Met Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Ala Asp Ile Asn Gln Asp 
            180                 185                 190         


Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Asn Leu 
    210                 215                 220                 


Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gln Ala Ile Arg Thr Thr 
225                 230                 235                 240 


Thr His Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


<210> 315
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 315
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                165                 170                 175     


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
                245                 250                 255     


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265             


<210> 316
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 316
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
                165                 170                 175     


Ser Tyr Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp 
                245                 250                 255     


Leu Asp Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


<210> 317
<211> 258
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 317
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr Asp Met Ser Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val Ser Ala Ile Thr Pro 
            180                 185                 190         


Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Thr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser 
        


<210> 318
<211> 254
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 318
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ala Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Gly Thr His Ala Met His Trp Val Arg Trp 
                165                 170                 175     


Ala Pro Gly Lys Gly Phe Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Gly Gly Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asp Asn Leu Lys 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ser Pro Ser Asn Ile Ala 
225                 230                 235                 240 


Asn Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 


<210> 319
<211> 268
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 319
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
                165                 170                 175     


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265             


<210> 320
<211> 512
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 320
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
        115                 120                 125             


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
    130                 135                 140                 


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
145                 150                 155                 160 


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
                165                 170                 175     


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
            180                 185                 190         


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
        195                 200                 205             


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
    210                 215                 220                 


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
225                 230                 235                 240 


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
                245                 250                 255     


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
            260                 265                 270         


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
        275                 280                 285             


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
    290                 295                 300                 


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
305                 310                 315                 320 


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
                325                 330                 335     


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
            340                 345                 350         


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
        355                 360                 365             


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
    370                 375                 380                 


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
385                 390                 395                 400 


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
                405                 410                 415     


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
            420                 425                 430         


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
        435                 440                 445             


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
    450                 455                 460                 


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
465                 470                 475                 480 


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
                485                 490                 495     


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            500                 505                 510         


<210> 321
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 321
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Pro Pro Ser Phe 
        115                 120                 125             


Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp 
    130                 135                 140                 


Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp 
145                 150                 155                 160 


Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser 
                165                 170                 175     


Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly 
            180                 185                 190         


Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln 
        195                 200                 205             


Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu 
    210                 215                 220                 


Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly 
225                 230                 235                 240 


Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu 
                245                 250                 255     


Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser 
            260                 265                 270         


Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala 
        275                 280                 285             


Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg 
    290                 295                 300                 


Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val 
305                 310                 315                 320 


Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu 
                325                 330                 335     


Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys 
            340                 345                 350         


Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu 
        355                 360                 365             


Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val 
    370                 375                 380                 


Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro 
385                 390                 395                 400 


Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln 
                405                 410                 415     


Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser 
            420                 425                 430         


Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val 
        435                 440                 445             


Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala 
    450                 455                 460                 


Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn 
465                 470                 475                 480 


Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu 
                485                 490                 495     


Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala 
            500                 505                 510         


Gln Ala Pro Leu Ala Gln 
        515             


<210> 322
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 322
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Pro Pro 
        115                 120                 125             


Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe 
    130                 135                 140                 


Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln 
145                 150                 155                 160 


Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala 
                165                 170                 175     


Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly 
            180                 185                 190         


Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala 
        195                 200                 205             


Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe 
    210                 215                 220                 


Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln 
225                 230                 235                 240 


Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg 
                245                 250                 255     


Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala 
            260                 265                 270         


Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg 
        275                 280                 285             


Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu 
    290                 295                 300                 


Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly 
305                 310                 315                 320 


Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile 
                325                 330                 335     


Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala 
            340                 345                 350         


Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu 
        355                 360                 365             


Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile 
    370                 375                 380                 


Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe 
385                 390                 395                 400 


Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala 
                405                 410                 415     


Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His 
            420                 425                 430         


Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln 
        435                 440                 445             


Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His 
    450                 455                 460                 


Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser 
465                 470                 475                 480 


Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu 
                485                 490                 495     


His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser 
            500                 505                 510         


Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520 


<210> 323
<211> 513
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 323
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly 
        115                 120                 125             


Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg 
    130                 135                 140                 


Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys 
145                 150                 155                 160 


Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu 
                165                 170                 175     


Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu 
            180                 185                 190         


His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr 
        195                 200                 205             


Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu 
    210                 215                 220                 


Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp 
225                 230                 235                 240 


Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr 
                245                 250                 255     


Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly 
            260                 265                 270         


Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met 
        275                 280                 285             


Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln 
    290                 295                 300                 


Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu 
305                 310                 315                 320 


Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro 
                325                 330                 335     


Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser 
            340                 345                 350         


Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val 
        355                 360                 365             


Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met 
    370                 375                 380                 


Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly 
385                 390                 395                 400 


Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro 
                405                 410                 415     


Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met 
            420                 425                 430         


Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp 
        435                 440                 445             


Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys 
    450                 455                 460                 


Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser 
465                 470                 475                 480 


Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met 
                485                 490                 495     


Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala 
            500                 505                 510         


Gln 
    


<210> 324
<211> 511
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 324
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser 
        115                 120                 125             


Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro 
    130                 135                 140                 


Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu 
145                 150                 155                 160 


Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg 
                165                 170                 175     


Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro 
            180                 185                 190         


Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr 
        195                 200                 205             


Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser 
    210                 215                 220                 


Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser 
225                 230                 235                 240 


Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp 
                245                 250                 255     


Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His 
            260                 265                 270         


Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys 
        275                 280                 285             


Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr 
    290                 295                 300                 


Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln 
305                 310                 315                 320 


Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met 
                325                 330                 335     


His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu 
            340                 345                 350         


Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala 
        355                 360                 365             


His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg 
    370                 375                 380                 


Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr 
385                 390                 395                 400 


Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val 
                405                 410                 415     


Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln 
            420                 425                 430         


Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu 
        435                 440                 445             


Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp 
    450                 455                 460                 


Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile 
465                 470                 475                 480 


Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val 
                485                 490                 495     


Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            500                 505                 510     


<210> 325
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 325
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Pro Pro Ser Phe 
        115                 120                 125             


Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp 
    130                 135                 140                 


Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp 
145                 150                 155                 160 


Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser 
                165                 170                 175     


Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly 
            180                 185                 190         


Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln 
        195                 200                 205             


Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu 
    210                 215                 220                 


Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly 
225                 230                 235                 240 


Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu 
                245                 250                 255     


Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser 
            260                 265                 270         


Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala 
        275                 280                 285             


Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg 
    290                 295                 300                 


Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val 
305                 310                 315                 320 


Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu 
                325                 330                 335     


Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys 
            340                 345                 350         


Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu 
        355                 360                 365             


Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val 
    370                 375                 380                 


Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro 
385                 390                 395                 400 


Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln 
                405                 410                 415     


Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser 
            420                 425                 430         


Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val 
        435                 440                 445             


Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala 
    450                 455                 460                 


Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn 
465                 470                 475                 480 


Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu 
                485                 490                 495     


Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala 
            500                 505                 510         


Gln Ala Pro Leu Ala Gln 
        515             


<210> 326
<211> 517
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 326
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser 
        115                 120                 125             


Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg 
    130                 135                 140                 


Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile 
145                 150                 155                 160 


Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser 
                165                 170                 175     


Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly 
            180                 185                 190         


Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu 
        195                 200                 205             


Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg 
    210                 215                 220                 


Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg 
225                 230                 235                 240 


Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro 
                245                 250                 255     


Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu 
            260                 265                 270         


Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu 
        275                 280                 285             


Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg 
    290                 295                 300                 


Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr 
305                 310                 315                 320 


Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala 
                325                 330                 335     


Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly 
            340                 345                 350         


Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe 
        355                 360                 365             


His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val 
    370                 375                 380                 


Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile 
385                 390                 395                 400 


Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys 
                405                 410                 415     


His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala 
            420                 425                 430         


Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile 
        435                 440                 445             


Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val 
    450                 455                 460                 


Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val 
465                 470                 475                 480 


Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu 
                485                 490                 495     


His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln 
            500                 505                 510         


Ala Pro Leu Ala Gln 
        515         


<210> 327
<211> 523
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 327
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu 
    130                 135                 140                 


Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu 
145                 150                 155                 160 


Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile 
                165                 170                 175     


Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser 
            180                 185                 190         


Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro 
        195                 200                 205             


Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe 
    210                 215                 220                 


Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala 
225                 230                 235                 240 


Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr 
                245                 250                 255     


Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu 
            260                 265                 270         


Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu 
        275                 280                 285             


Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys 
    290                 295                 300                 


Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys 
305                 310                 315                 320 


Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn 
                325                 330                 335     


Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr 
            340                 345                 350         


Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr 
        355                 360                 365             


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg 
    370                 375                 380                 


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
385                 390                 395                 400 


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
                405                 410                 415     


Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp 
            420                 425                 430         


Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr 
        435                 440                 445             


Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu 
    450                 455                 460                 


Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys 
465                 470                 475                 480 


Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu 
                485                 490                 495     


Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro 
            500                 505                 510         


Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520             


<210> 328
<211> 525
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 328
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
        115                 120                 125             


Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr 
    130                 135                 140                 


Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro 
145                 150                 155                 160 


Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg 
                165                 170                 175     


Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His 
            180                 185                 190         


Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu 
        195                 200                 205             


Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu 
    210                 215                 220                 


Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu 
225                 230                 235                 240 


Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp 
                245                 250                 255     


Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn 
            260                 265                 270         


Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg 
        275                 280                 285             


Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val 
    290                 295                 300                 


Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln 
305                 310                 315                 320 


Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu 
                325                 330                 335     


Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu 
            340                 345                 350         


Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro 
        355                 360                 365             


Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val 
    370                 375                 380                 


Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser 
385                 390                 395                 400 


Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro 
                405                 410                 415     


Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala 
            420                 425                 430         


Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu 
        435                 440                 445             


Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys 
    450                 455                 460                 


Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp 
465                 470                 475                 480 


Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser 
                485                 490                 495     


Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp 
            500                 505                 510         


Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520                 525 


<210> 329
<211> 518
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 329
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe 
        115                 120                 125             


Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp 
    130                 135                 140                 


Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp 
145                 150                 155                 160 


Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser 
                165                 170                 175     


Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly 
            180                 185                 190         


Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln 
        195                 200                 205             


Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu 
    210                 215                 220                 


Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly 
225                 230                 235                 240 


Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu 
                245                 250                 255     


Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser 
            260                 265                 270         


Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala 
        275                 280                 285             


Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg 
    290                 295                 300                 


Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val 
305                 310                 315                 320 


Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu 
                325                 330                 335     


Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys 
            340                 345                 350         


Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu 
        355                 360                 365             


Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val 
    370                 375                 380                 


Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro 
385                 390                 395                 400 


Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln 
                405                 410                 415     


Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser 
            420                 425                 430         


Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val 
        435                 440                 445             


Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala 
    450                 455                 460                 


Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn 
465                 470                 475                 480 


Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu 
                485                 490                 495     


Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala 
            500                 505                 510         


Gln Ala Pro Leu Ala Gln 
        515             


<210> 330
<211> 516
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 330
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu 
        115                 120                 125             


Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu 
    130                 135                 140                 


Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val 
145                 150                 155                 160 


Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile 
                165                 170                 175     


Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly 
            180                 185                 190         


Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro 
        195                 200                 205             


Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp 
    210                 215                 220                 


Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu 
225                 230                 235                 240 


Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu 
                245                 250                 255     


Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly 
            260                 265                 270         


Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr 
        275                 280                 285             


Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp 
    290                 295                 300                 


Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr 
305                 310                 315                 320 


Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser 
                325                 330                 335     


Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly 
            340                 345                 350         


Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His 
        355                 360                 365             


Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala 
    370                 375                 380                 


Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro 
385                 390                 395                 400 


Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His 
                405                 410                 415     


Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu 
            420                 425                 430         


Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro 
        435                 440                 445             


Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp 
    450                 455                 460                 


Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg 
465                 470                 475                 480 


Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His 
                485                 490                 495     


Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala 
            500                 505                 510         


Pro Leu Ala Gln 
        515     


<210> 331
<211> 523
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 331
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu 
    130                 135                 140                 


Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu 
145                 150                 155                 160 


Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile 
                165                 170                 175     


Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser 
            180                 185                 190         


Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro 
        195                 200                 205             


Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe 
    210                 215                 220                 


Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala 
225                 230                 235                 240 


Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr 
                245                 250                 255     


Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu 
            260                 265                 270         


Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu 
        275                 280                 285             


Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys 
    290                 295                 300                 


Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys 
305                 310                 315                 320 


Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn 
                325                 330                 335     


Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr 
            340                 345                 350         


Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr 
        355                 360                 365             


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg 
    370                 375                 380                 


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
385                 390                 395                 400 


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
                405                 410                 415     


Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp 
            420                 425                 430         


Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr 
        435                 440                 445             


Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu 
    450                 455                 460                 


Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys 
465                 470                 475                 480 


Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu 
                485                 490                 495     


Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro 
            500                 505                 510         


Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520             


<210> 332
<211> 522
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 332
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
        115                 120                 125             


Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
    130                 135                 140                 


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
145                 150                 155                 160 


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
                165                 170                 175     


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
            180                 185                 190         


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
        195                 200                 205             


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
    210                 215                 220                 


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
225                 230                 235                 240 


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
                245                 250                 255     


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
            260                 265                 270         


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
        275                 280                 285             


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
    290                 295                 300                 


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
305                 310                 315                 320 


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
                325                 330                 335     


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
            340                 345                 350         


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
        355                 360                 365             


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
    370                 375                 380                 


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
385                 390                 395                 400 


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
                405                 410                 415     


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
            420                 425                 430         


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
        435                 440                 445             


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
    450                 455                 460                 


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
465                 470                 475                 480 


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
                485                 490                 495     


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
            500                 505                 510         


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520         


<210> 333
<211> 528
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 333
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
    130                 135                 140                 


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
145                 150                 155                 160 


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
                165                 170                 175     


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
            180                 185                 190         


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
        195                 200                 205             


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
    210                 215                 220                 


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
225                 230                 235                 240 


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
                245                 250                 255     


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
            260                 265                 270         


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
        275                 280                 285             


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
    290                 295                 300                 


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
305                 310                 315                 320 


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
                325                 330                 335     


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
            340                 345                 350         


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
        355                 360                 365             


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
    370                 375                 380                 


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
385                 390                 395                 400 


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
                405                 410                 415     


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
            420                 425                 430         


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
        435                 440                 445             


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
    450                 455                 460                 


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
465                 470                 475                 480 


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
                485                 490                 495     


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
            500                 505                 510         


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520                 525             


<210> 334
<211> 530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 334
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
        115                 120                 125             


Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser 
    130                 135                 140                 


Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr 
145                 150                 155                 160 


Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu 
                165                 170                 175     


Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser 
            180                 185                 190         


Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn 
        195                 200                 205             


Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu 
    210                 215                 220                 


Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
225                 230                 235                 240 


Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
                245                 250                 255     


Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr 
            260                 265                 270         


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
        275                 280                 285             


Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu 
    290                 295                 300                 


Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp 
305                 310                 315                 320 


Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp 
                325                 330                 335     


Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu 
            340                 345                 350         


Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu 
        355                 360                 365             


Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe 
    370                 375                 380                 


Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr 
385                 390                 395                 400 


Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly 
                405                 410                 415     


Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser 
            420                 425                 430         


Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser 
        435                 440                 445             


Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr 
    450                 455                 460                 


Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly 
465                 470                 475                 480 


Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala 
                485                 490                 495     


Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr 
            500                 505                 510         


Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu 
        515                 520                 525             


Ala Gln 
    530 


<210> 335
<211> 523
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 335
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu 
    130                 135                 140                 


Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu 
145                 150                 155                 160 


Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile 
                165                 170                 175     


Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser 
            180                 185                 190         


Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro 
        195                 200                 205             


Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe 
    210                 215                 220                 


Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala 
225                 230                 235                 240 


Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr 
                245                 250                 255     


Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu 
            260                 265                 270         


Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu 
        275                 280                 285             


Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys 
    290                 295                 300                 


Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys 
305                 310                 315                 320 


Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn 
                325                 330                 335     


Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr 
            340                 345                 350         


Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr 
        355                 360                 365             


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg 
    370                 375                 380                 


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
385                 390                 395                 400 


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
                405                 410                 415     


Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp 
            420                 425                 430         


Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr 
        435                 440                 445             


Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu 
    450                 455                 460                 


Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys 
465                 470                 475                 480 


Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu 
                485                 490                 495     


Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro 
            500                 505                 510         


Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520             


<210> 336
<211> 521
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 336
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro 
        115                 120                 125             


Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly 
    130                 135                 140                 


Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg 
145                 150                 155                 160 


Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His 
                165                 170                 175     


Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn 
            180                 185                 190         


Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys 
        195                 200                 205             


Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser 
    210                 215                 220                 


Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu 
225                 230                 235                 240 


Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln 
                245                 250                 255     


Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His 
            260                 265                 270         


Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu 
        275                 280                 285             


Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala 
    290                 295                 300                 


Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser 
305                 310                 315                 320 


Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu 
                325                 330                 335     


Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly 
            340                 345                 350         


Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser 
        355                 360                 365             


Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro 
    370                 375                 380                 


Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala 
385                 390                 395                 400 


Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro 
                405                 410                 415     


Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala 
            420                 425                 430         


His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu 
        435                 440                 445             


Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu 
    450                 455                 460                 


His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp 
465                 470                 475                 480 


Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys 
                485                 490                 495     


Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser 
            500                 505                 510         


Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520     


<210> 337
<211> 528
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 337
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
    130                 135                 140                 


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
145                 150                 155                 160 


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
                165                 170                 175     


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
            180                 185                 190         


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
        195                 200                 205             


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
    210                 215                 220                 


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
225                 230                 235                 240 


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
                245                 250                 255     


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
            260                 265                 270         


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
        275                 280                 285             


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
    290                 295                 300                 


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
305                 310                 315                 320 


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
                325                 330                 335     


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
            340                 345                 350         


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
        355                 360                 365             


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
    370                 375                 380                 


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
385                 390                 395                 400 


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
                405                 410                 415     


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
            420                 425                 430         


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
        435                 440                 445             


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
    450                 455                 460                 


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
465                 470                 475                 480 


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
                485                 490                 495     


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
            500                 505                 510         


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520                 525             


<210> 338
<211> 527
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 338
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
        115                 120                 125             


Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser 
    130                 135                 140                 


Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro 
145                 150                 155                 160 


Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu 
                165                 170                 175     


Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg 
            180                 185                 190         


Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro 
        195                 200                 205             


Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr 
    210                 215                 220                 


Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser 
225                 230                 235                 240 


Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser 
                245                 250                 255     


Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp 
            260                 265                 270         


Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His 
        275                 280                 285             


Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys 
    290                 295                 300                 


Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr 
305                 310                 315                 320 


Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln 
                325                 330                 335     


Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met 
            340                 345                 350         


His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu 
        355                 360                 365             


Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala 
    370                 375                 380                 


His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg 
385                 390                 395                 400 


Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr 
                405                 410                 415     


Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val 
            420                 425                 430         


Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln 
        435                 440                 445             


Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu 
    450                 455                 460                 


Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp 
465                 470                 475                 480 


Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile 
                485                 490                 495     


Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val 
            500                 505                 510         


Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520                 525         


<210> 339
<211> 533
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 339
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser 
    130                 135                 140                 


Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg 
145                 150                 155                 160 


Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile 
                165                 170                 175     


Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser 
            180                 185                 190         


Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly 
        195                 200                 205             


Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu 
    210                 215                 220                 


Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg 
225                 230                 235                 240 


Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg 
                245                 250                 255     


Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro 
            260                 265                 270         


Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu 
        275                 280                 285             


Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu 
    290                 295                 300                 


Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg 
305                 310                 315                 320 


Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr 
                325                 330                 335     


Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala 
            340                 345                 350         


Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly 
        355                 360                 365             


Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe 
    370                 375                 380                 


His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val 
385                 390                 395                 400 


Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile 
                405                 410                 415     


Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys 
            420                 425                 430         


His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala 
        435                 440                 445             


Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile 
    450                 455                 460                 


Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val 
465                 470                 475                 480 


Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val 
                485                 490                 495     


Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu 
            500                 505                 510         


His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln 
        515                 520                 525             


Ala Pro Leu Ala Gln 
    530             


<210> 340
<211> 535
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 340
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
        115                 120                 125             


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser 
    130                 135                 140                 


Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser 
145                 150                 155                 160 


Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp 
                165                 170                 175     


Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser 
            180                 185                 190         


Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly 
        195                 200                 205             


Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe 
    210                 215                 220                 


Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile 
225                 230                 235                 240 


Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala 
                245                 250                 255     


Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu 
            260                 265                 270         


Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala 
        275                 280                 285             


Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys 
    290                 295                 300                 


Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys 
305                 310                 315                 320 


Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu 
                325                 330                 335     


Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys 
            340                 345                 350         


Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn 
        355                 360                 365             


Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu 
    370                 375                 380                 


Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val 
385                 390                 395                 400 


Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala 
                405                 410                 415     


Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser 
            420                 425                 430         


Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe 
        435                 440                 445             


Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala 
    450                 455                 460                 


Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe 
465                 470                 475                 480 


Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp 
                485                 490                 495     


Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His 
            500                 505                 510         


Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp 
        515                 520                 525             


Ala Gln Ala Pro Leu Ala Gln 
    530                 535 


<210> 341
<211> 528
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 341
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
    130                 135                 140                 


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
145                 150                 155                 160 


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
                165                 170                 175     


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
            180                 185                 190         


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
        195                 200                 205             


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
    210                 215                 220                 


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
225                 230                 235                 240 


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
                245                 250                 255     


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
            260                 265                 270         


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
        275                 280                 285             


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
    290                 295                 300                 


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
305                 310                 315                 320 


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
                325                 330                 335     


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
            340                 345                 350         


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
        355                 360                 365             


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
    370                 375                 380                 


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
385                 390                 395                 400 


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
                405                 410                 415     


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
            420                 425                 430         


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
        435                 440                 445             


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
    450                 455                 460                 


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
465                 470                 475                 480 


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
                485                 490                 495     


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
            500                 505                 510         


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520                 525             


<210> 342
<211> 526
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 342
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly 
        115                 120                 125             


Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
    130                 135                 140                 


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
145                 150                 155                 160 


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
                165                 170                 175     


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
            180                 185                 190         


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
        195                 200                 205             


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
    210                 215                 220                 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
225                 230                 235                 240 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
                245                 250                 255     


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
            260                 265                 270         


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
        275                 280                 285             


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
    290                 295                 300                 


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
305                 310                 315                 320 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
                325                 330                 335     


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
            340                 345                 350         


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
        355                 360                 365             


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
    370                 375                 380                 


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
385                 390                 395                 400 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
                405                 410                 415     


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
            420                 425                 430         


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys 
        435                 440                 445             


Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr 
    450                 455                 460                 


Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu 
465                 470                 475                 480 


Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu 
                485                 490                 495     


Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys 
            500                 505                 510         


Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        515                 520                 525     


<210> 343
<211> 533
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 343
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser 
    130                 135                 140                 


Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg 
145                 150                 155                 160 


Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile 
                165                 170                 175     


Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser 
            180                 185                 190         


Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly 
        195                 200                 205             


Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu 
    210                 215                 220                 


Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg 
225                 230                 235                 240 


Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg 
                245                 250                 255     


Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro 
            260                 265                 270         


Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu 
        275                 280                 285             


Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu 
    290                 295                 300                 


Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg 
305                 310                 315                 320 


Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr 
                325                 330                 335     


Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala 
            340                 345                 350         


Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly 
        355                 360                 365             


Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe 
    370                 375                 380                 


His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val 
385                 390                 395                 400 


Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile 
                405                 410                 415     


Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys 
            420                 425                 430         


His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala 
        435                 440                 445             


Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile 
    450                 455                 460                 


Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val 
465                 470                 475                 480 


Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val 
                485                 490                 495     


Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu 
            500                 505                 510         


His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln 
        515                 520                 525             


Ala Pro Leu Ala Gln 
    530             


<210> 344
<211> 650
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 344
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe Pro Met Met Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Ala Asp Ile Asn Gln Asp 
            180                 185                 190         


Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Asn Leu 
    210                 215                 220                 


Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gln Ala Ile Arg Thr Thr 
225                 230                 235                 240 


Thr His Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
            260                 265                 270         


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
        275                 280                 285             


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
    290                 295                 300                 


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
305                 310                 315                 320 


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
                325                 330                 335     


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
            340                 345                 350         


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
        355                 360                 365             


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
    370                 375                 380                 


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
385                 390                 395                 400 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
                405                 410                 415     


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
            420                 425                 430         


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
        435                 440                 445             


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
    450                 455                 460                 


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
465                 470                 475                 480 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
                485                 490                 495     


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
            500                 505                 510         


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
        515                 520                 525             


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
    530                 535                 540                 


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
545                 550                 555                 560 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
                565                 570                 575     


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
            580                 585                 590         


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
        595                 600                 605             


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
    610                 615                 620                 


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
625                 630                 635                 640 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                645                 650 


<210> 345
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 345
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                165                 170                 175     


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
                245                 250                 255     


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Pro Pro Ser Phe 
            260                 265                 270         


Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp 
        275                 280                 285             


Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp 
    290                 295                 300                 


Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser 
305                 310                 315                 320 


Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly 
                325                 330                 335     


Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln 
            340                 345                 350         


Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu 
        355                 360                 365             


Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly 
    370                 375                 380                 


Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser 
                405                 410                 415     


Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala 
            420                 425                 430         


Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg 
        435                 440                 445             


Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val 
    450                 455                 460                 


Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu 
465                 470                 475                 480 


Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys 
                485                 490                 495     


Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu 
            500                 505                 510         


Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val 
        515                 520                 525             


Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro 
    530                 535                 540                 


Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln 
545                 550                 555                 560 


Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser 
                565                 570                 575     


Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val 
            580                 585                 590         


Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala 
        595                 600                 605             


Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn 
    610                 615                 620                 


Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu 
625                 630                 635                 640 


Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala 
                645                 650                 655     


Gln Ala Pro Leu Ala Gln 
            660         


<210> 346
<211> 666
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 346
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
                165                 170                 175     


Ser Tyr Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp 
                245                 250                 255     


Leu Asp Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
        275                 280                 285             


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
    290                 295                 300                 


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
305                 310                 315                 320 


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
                325                 330                 335     


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
            340                 345                 350         


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
        355                 360                 365             


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
    370                 375                 380                 


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
385                 390                 395                 400 


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
                405                 410                 415     


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
            420                 425                 430         


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
        435                 440                 445             


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
    450                 455                 460                 


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
465                 470                 475                 480 


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
                485                 490                 495     


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
            500                 505                 510         


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
        515                 520                 525             


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
    530                 535                 540                 


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
545                 550                 555                 560 


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
                565                 570                 575     


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
            580                 585                 590         


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
        595                 600                 605             


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
    610                 615                 620                 


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
625                 630                 635                 640 


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
                645                 650                 655     


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            660                 665     


<210> 347
<211> 652
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 347
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr Asp Met Ser Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val Ser Ala Ile Thr Pro 
            180                 185                 190         


Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Thr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro 
            260                 265                 270         


Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile 
        275                 280                 285             


Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly 
    290                 295                 300                 


Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val 
305                 310                 315                 320 


Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met 
                325                 330                 335     


Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp 
            340                 345                 350         


Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val 
        355                 360                 365             


Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro 
    370                 375                 380                 


Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys 
385                 390                 395                 400 


Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp 
                405                 410                 415     


Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu 
            420                 425                 430         


Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn 
        435                 440                 445             


Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp 
    450                 455                 460                 


Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly 
465                 470                 475                 480 


Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val 
                485                 490                 495     


Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu 
            500                 505                 510         


Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly 
        515                 520                 525             


Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu 
    530                 535                 540                 


Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr 
545                 550                 555                 560 


Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn 
                565                 570                 575     


Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu 
            580                 585                 590         


Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly 
        595                 600                 605             


Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu 
    610                 615                 620                 


Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile 
625                 630                 635                 640 


Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                645                 650         


<210> 348
<211> 648
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 348
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ala Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Gly Thr His Ala Met His Trp Val Arg Trp 
                165                 170                 175     


Ala Pro Gly Lys Gly Phe Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Gly Gly Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asp Asn Leu Lys 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ser Pro Ser Asn Ile Ala 
225                 230                 235                 240 


Asn Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Pro Pro 
                245                 250                 255     


Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe 
            260                 265                 270         


Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln 
        275                 280                 285             


Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala 
    290                 295                 300                 


Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala 
                325                 330                 335     


Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe 
            340                 345                 350         


Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln 
        355                 360                 365             


Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg 
    370                 375                 380                 


Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala 
385                 390                 395                 400 


Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg 
                405                 410                 415     


Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu 
            420                 425                 430         


Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly 
        435                 440                 445             


Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile 
    450                 455                 460                 


Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala 
465                 470                 475                 480 


Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu 
                485                 490                 495     


Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile 
            500                 505                 510         


Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe 
        515                 520                 525             


Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala 
    530                 535                 540                 


Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His 
545                 550                 555                 560 


Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln 
                565                 570                 575     


Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His 
            580                 585                 590         


Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser 
        595                 600                 605             


Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu 
    610                 615                 620                 


His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser 
625                 630                 635                 640 


Asp Ala Gln Ala Pro Leu Ala Gln 
                645             


<210> 349
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 349
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
                165                 170                 175     


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Pro Pro Ser Phe 
            260                 265                 270         


Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp 
        275                 280                 285             


Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp 
    290                 295                 300                 


Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser 
305                 310                 315                 320 


Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly 
                325                 330                 335     


Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln 
            340                 345                 350         


Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu 
        355                 360                 365             


Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly 
    370                 375                 380                 


Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser 
                405                 410                 415     


Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala 
            420                 425                 430         


Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg 
        435                 440                 445             


Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val 
    450                 455                 460                 


Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu 
465                 470                 475                 480 


Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys 
                485                 490                 495     


Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu 
            500                 505                 510         


Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val 
        515                 520                 525             


Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro 
    530                 535                 540                 


Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln 
545                 550                 555                 560 


Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser 
                565                 570                 575     


Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val 
            580                 585                 590         


Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala 
        595                 600                 605             


Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn 
    610                 615                 620                 


Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu 
625                 630                 635                 640 


Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala 
                645                 650                 655     


Gln Ala Pro Leu Ala Gln 
            660         


<210> 350
<211> 655
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 350
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe Pro Met Met Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Ala Asp Ile Asn Gln Asp 
            180                 185                 190         


Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Asn Leu 
    210                 215                 220                 


Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gln Ala Ile Arg Thr Thr 
225                 230                 235                 240 


Thr His Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser 
            260                 265                 270         


Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro 
        275                 280                 285             


Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu 
    290                 295                 300                 


Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg 
305                 310                 315                 320 


Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro 
                325                 330                 335     


Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr 
            340                 345                 350         


Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser 
        355                 360                 365             


Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser 
    370                 375                 380                 


Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp 
385                 390                 395                 400 


Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His 
                405                 410                 415     


Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys 
            420                 425                 430         


Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr 
        435                 440                 445             


Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln 
    450                 455                 460                 


Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met 
465                 470                 475                 480 


His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu 
                485                 490                 495     


Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala 
            500                 505                 510         


His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg 
        515                 520                 525             


Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr 
    530                 535                 540                 


Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val 
545                 550                 555                 560 


Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln 
                565                 570                 575     


Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu 
            580                 585                 590         


Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp 
        595                 600                 605             


Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile 
    610                 615                 620                 


Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val 
625                 630                 635                 640 


Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                645                 650                 655 


<210> 351
<211> 667
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 351
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                165                 170                 175     


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
                245                 250                 255     


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
            260                 265                 270         


Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu 
        275                 280                 285             


Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu 
    290                 295                 300                 


Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile 
305                 310                 315                 320 


Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser 
                325                 330                 335     


Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro 
            340                 345                 350         


Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe 
        355                 360                 365             


Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala 
    370                 375                 380                 


Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr 
385                 390                 395                 400 


Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu 
                405                 410                 415     


Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu 
            420                 425                 430         


Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys 
        435                 440                 445             


Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys 
    450                 455                 460                 


Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn 
465                 470                 475                 480 


Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr 
                485                 490                 495     


Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr 
            500                 505                 510         


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg 
        515                 520                 525             


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
    530                 535                 540                 


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
545                 550                 555                 560 


Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp 
                565                 570                 575     


Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr 
            580                 585                 590         


Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu 
        595                 600                 605             


Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys 
    610                 615                 620                 


Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu 
625                 630                 635                 640 


Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro 
                645                 650                 655     


Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            660                 665         


<210> 352
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 352
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
                165                 170                 175     


Ser Tyr Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp 
                245                 250                 255     


Leu Asp Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser 
        275                 280                 285             


Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro 
    290                 295                 300                 


Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu 
305                 310                 315                 320 


Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg 
                325                 330                 335     


Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro 
            340                 345                 350         


Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr 
        355                 360                 365             


Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser 
    370                 375                 380                 


Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser 
385                 390                 395                 400 


Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp 
                405                 410                 415     


Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His 
            420                 425                 430         


Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys 
        435                 440                 445             


Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr 
    450                 455                 460                 


Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln 
465                 470                 475                 480 


Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met 
                485                 490                 495     


His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu 
            500                 505                 510         


Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala 
        515                 520                 525             


His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg 
    530                 535                 540                 


Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr 
545                 550                 555                 560 


Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val 
                565                 570                 575     


Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln 
            580                 585                 590         


Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu 
        595                 600                 605             


Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp 
    610                 615                 620                 


Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile 
625                 630                 635                 640 


Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val 
                645                 650                 655     


Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            660                 665                 670     


<210> 353
<211> 657
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 353
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr Asp Met Ser Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val Ser Ala Ile Thr Pro 
            180                 185                 190         


Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Thr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly 
            260                 265                 270         


Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg 
        275                 280                 285             


Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys 
    290                 295                 300                 


Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu 
305                 310                 315                 320 


Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu 
                325                 330                 335     


His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr 
            340                 345                 350         


Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu 
        355                 360                 365             


Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp 
    370                 375                 380                 


Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr 
385                 390                 395                 400 


Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly 
                405                 410                 415     


Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met 
            420                 425                 430         


Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln 
        435                 440                 445             


Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu 
    450                 455                 460                 


Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro 
465                 470                 475                 480 


Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser 
                485                 490                 495     


Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val 
            500                 505                 510         


Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met 
        515                 520                 525             


Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly 
    530                 535                 540                 


Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro 
545                 550                 555                 560 


Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met 
                565                 570                 575     


Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp 
            580                 585                 590         


Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys 
        595                 600                 605             


Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser 
    610                 615                 620                 


Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met 
625                 630                 635                 640 


Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala 
                645                 650                 655     


Gln 
    


<210> 354
<211> 653
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 354
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ala Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Gly Thr His Ala Met His Trp Val Arg Trp 
                165                 170                 175     


Ala Pro Gly Lys Gly Phe Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Gly Gly Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asp Asn Leu Lys 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ser Pro Ser Asn Ile Ala 
225                 230                 235                 240 


Asn Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
                245                 250                 255     


Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr 
            260                 265                 270         


Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro 
        275                 280                 285             


Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg 
    290                 295                 300                 


Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His 
305                 310                 315                 320 


Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu 
                325                 330                 335     


Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu 
            340                 345                 350         


Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu 
        355                 360                 365             


Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp 
    370                 375                 380                 


Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn 
385                 390                 395                 400 


Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg 
                405                 410                 415     


Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val 
            420                 425                 430         


Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln 
        435                 440                 445             


Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu 
    450                 455                 460                 


Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu 
465                 470                 475                 480 


Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro 
                485                 490                 495     


Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val 
            500                 505                 510         


Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser 
        515                 520                 525             


Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro 
    530                 535                 540                 


Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala 
545                 550                 555                 560 


Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu 
                565                 570                 575     


Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys 
            580                 585                 590         


Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp 
        595                 600                 605             


Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser 
    610                 615                 620                 


Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp 
625                 630                 635                 640 


Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                645                 650             


<210> 355
<211> 667
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 355
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
                165                 170                 175     


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
            260                 265                 270         


Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu 
        275                 280                 285             


Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu 
    290                 295                 300                 


Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile 
305                 310                 315                 320 


Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser 
                325                 330                 335     


Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro 
            340                 345                 350         


Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe 
        355                 360                 365             


Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala 
    370                 375                 380                 


Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr 
385                 390                 395                 400 


Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu 
                405                 410                 415     


Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu 
            420                 425                 430         


Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys 
        435                 440                 445             


Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys 
    450                 455                 460                 


Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn 
465                 470                 475                 480 


Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr 
                485                 490                 495     


Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr 
            500                 505                 510         


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg 
        515                 520                 525             


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
    530                 535                 540                 


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
545                 550                 555                 560 


Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp 
                565                 570                 575     


Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr 
            580                 585                 590         


Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu 
        595                 600                 605             


Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys 
    610                 615                 620                 


Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu 
625                 630                 635                 640 


Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro 
                645                 650                 655     


Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            660                 665         


<210> 356
<211> 660
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 356
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe Pro Met Met Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Ala Asp Ile Asn Gln Asp 
            180                 185                 190         


Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Asn Leu 
    210                 215                 220                 


Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gln Ala Ile Arg Thr Thr 
225                 230                 235                 240 


Thr His Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu 
            260                 265                 270         


Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu 
        275                 280                 285             


Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val 
    290                 295                 300                 


Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile 
305                 310                 315                 320 


Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly 
                325                 330                 335     


Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro 
            340                 345                 350         


Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp 
        355                 360                 365             


Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu 
    370                 375                 380                 


Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu 
385                 390                 395                 400 


Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly 
                405                 410                 415     


Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr 
            420                 425                 430         


Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp 
        435                 440                 445             


Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr 
    450                 455                 460                 


Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser 
465                 470                 475                 480 


Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly 
                485                 490                 495     


Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His 
            500                 505                 510         


Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala 
        515                 520                 525             


Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro 
    530                 535                 540                 


Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His 
545                 550                 555                 560 


Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu 
                565                 570                 575     


Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro 
            580                 585                 590         


Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp 
        595                 600                 605             


Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg 
    610                 615                 620                 


Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His 
625                 630                 635                 640 


Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala 
                645                 650                 655     


Pro Leu Ala Gln 
            660 


<210> 357
<211> 672
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 357
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                165                 170                 175     


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
                245                 250                 255     


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
            260                 265                 270         


Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
        275                 280                 285             


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
    290                 295                 300                 


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
305                 310                 315                 320 


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
                325                 330                 335     


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
            340                 345                 350         


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
        355                 360                 365             


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
    370                 375                 380                 


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
385                 390                 395                 400 


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
                405                 410                 415     


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
            420                 425                 430         


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
        435                 440                 445             


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
    450                 455                 460                 


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
465                 470                 475                 480 


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
                485                 490                 495     


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
            500                 505                 510         


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
        515                 520                 525             


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
    530                 535                 540                 


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
545                 550                 555                 560 


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
                565                 570                 575     


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
            580                 585                 590         


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
        595                 600                 605             


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
    610                 615                 620                 


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
625                 630                 635                 640 


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
                645                 650                 655     


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            660                 665                 670         


<210> 358
<211> 676
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 358
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
                165                 170                 175     


Ser Tyr Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp 
                245                 250                 255     


Leu Asp Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu 
        275                 280                 285             


Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu 
    290                 295                 300                 


Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val 
305                 310                 315                 320 


Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile 
                325                 330                 335     


Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly 
            340                 345                 350         


Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro 
        355                 360                 365             


Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp 
    370                 375                 380                 


Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu 
385                 390                 395                 400 


Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu 
                405                 410                 415     


Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly 
            420                 425                 430         


Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr 
        435                 440                 445             


Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp 
    450                 455                 460                 


Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr 
465                 470                 475                 480 


Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser 
                485                 490                 495     


Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly 
            500                 505                 510         


Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His 
        515                 520                 525             


Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala 
    530                 535                 540                 


Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro 
545                 550                 555                 560 


Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His 
                565                 570                 575     


Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu 
            580                 585                 590         


Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro 
        595                 600                 605             


Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp 
    610                 615                 620                 


Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg 
625                 630                 635                 640 


Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His 
                645                 650                 655     


Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala 
            660                 665                 670         


Pro Leu Ala Gln 
        675     


<210> 359
<211> 662
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 359
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr Asp Met Ser Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val Ser Ala Ile Thr Pro 
            180                 185                 190         


Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Thr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe 
            260                 265                 270         


Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp 
        275                 280                 285             


Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp 
    290                 295                 300                 


Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser 
305                 310                 315                 320 


Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly 
                325                 330                 335     


Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln 
            340                 345                 350         


Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu 
        355                 360                 365             


Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly 
    370                 375                 380                 


Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser 
                405                 410                 415     


Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala 
            420                 425                 430         


Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg 
        435                 440                 445             


Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val 
    450                 455                 460                 


Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu 
465                 470                 475                 480 


Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys 
                485                 490                 495     


Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu 
            500                 505                 510         


Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val 
        515                 520                 525             


Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro 
    530                 535                 540                 


Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln 
545                 550                 555                 560 


Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser 
                565                 570                 575     


Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val 
            580                 585                 590         


Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala 
        595                 600                 605             


Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn 
    610                 615                 620                 


Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu 
625                 630                 635                 640 


Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala 
                645                 650                 655     


Gln Ala Pro Leu Ala Gln 
            660         


<210> 360
<211> 658
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 360
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ala Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Gly Thr His Ala Met His Trp Val Arg Trp 
                165                 170                 175     


Ala Pro Gly Lys Gly Phe Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Gly Gly Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asp Asn Leu Lys 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ser Pro Ser Asn Ile Ala 
225                 230                 235                 240 


Asn Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
                245                 250                 255     


Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser 
            260                 265                 270         


Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr 
        275                 280                 285             


Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu 
    290                 295                 300                 


Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser 
305                 310                 315                 320 


Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn 
                325                 330                 335     


Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu 
            340                 345                 350         


Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
        355                 360                 365             


Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
    370                 375                 380                 


Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr 
385                 390                 395                 400 


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
                405                 410                 415     


Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu 
            420                 425                 430         


Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp 
        435                 440                 445             


Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp 
    450                 455                 460                 


Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu 
465                 470                 475                 480 


Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu 
                485                 490                 495     


Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe 
            500                 505                 510         


Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr 
        515                 520                 525             


Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly 
    530                 535                 540                 


Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser 
545                 550                 555                 560 


Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser 
                565                 570                 575     


Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr 
            580                 585                 590         


Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly 
        595                 600                 605             


Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala 
    610                 615                 620                 


Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr 
625                 630                 635                 640 


Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu 
                645                 650                 655     


Ala Gln 
        


<210> 361
<211> 672
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 361
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
                165                 170                 175     


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
            260                 265                 270         


Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
        275                 280                 285             


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
    290                 295                 300                 


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
305                 310                 315                 320 


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
                325                 330                 335     


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
            340                 345                 350         


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
        355                 360                 365             


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
    370                 375                 380                 


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
385                 390                 395                 400 


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
                405                 410                 415     


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
            420                 425                 430         


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
        435                 440                 445             


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
    450                 455                 460                 


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
465                 470                 475                 480 


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
                485                 490                 495     


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
            500                 505                 510         


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
        515                 520                 525             


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
    530                 535                 540                 


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
545                 550                 555                 560 


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
                565                 570                 575     


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
            580                 585                 590         


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
        595                 600                 605             


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
    610                 615                 620                 


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
625                 630                 635                 640 


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
                645                 650                 655     


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            660                 665                 670         


<210> 362
<211> 665
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 362
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe 
            20                  25                  30          


Pro Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Arg Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Gln Asp Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asn Leu Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Gln Ala Ile Arg Thr Thr Thr His Phe Asp Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Phe Ser Phe Ser Asn Phe Pro Met Met Trp Val Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Gly Arg Glu Trp Val Ala Asp Ile Asn Gln Asp 
            180                 185                 190         


Gly Arg Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        195                 200                 205             


Ser Arg Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Asn Leu 
    210                 215                 220                 


Asn Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gln Ala Ile Arg Thr Thr 
225                 230                 235                 240 


Thr His Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro 
            260                 265                 270         


Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly 
        275                 280                 285             


Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg 
    290                 295                 300                 


Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His 
305                 310                 315                 320 


Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn 
                325                 330                 335     


Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys 
            340                 345                 350         


Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser 
        355                 360                 365             


Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu 
    370                 375                 380                 


Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln 
385                 390                 395                 400 


Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His 
                405                 410                 415     


Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu 
            420                 425                 430         


Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala 
        435                 440                 445             


Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser 
    450                 455                 460                 


Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu 
465                 470                 475                 480 


Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly 
                485                 490                 495     


Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser 
            500                 505                 510         


Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro 
        515                 520                 525             


Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala 
    530                 535                 540                 


Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro 
545                 550                 555                 560 


Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala 
                565                 570                 575     


His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu 
            580                 585                 590         


Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu 
        595                 600                 605             


His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp 
    610                 615                 620                 


Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys 
625                 630                 635                 640 


Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser 
                645                 650                 655     


Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            660                 665 


<210> 363
<211> 677
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 363
Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
            100                 105                 110         


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Leu Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
                165                 170                 175     


Arg Met Tyr Trp Val Arg Met Ala Pro Gly Lys Gly Leu Glu Trp Val 
            180                 185                 190         


Ser Asp Ile Asp Arg Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Asp Arg Arg Leu Ile Val Asp Leu Thr Pro Glu Val Tyr Asp 
                245                 250                 255     


His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
            260                 265                 270         


Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser 
        275                 280                 285             


Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg 
    290                 295                 300                 


Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile 
305                 310                 315                 320 


Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser 
                325                 330                 335     


Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly 
            340                 345                 350         


Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu 
        355                 360                 365             


Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg 
    370                 375                 380                 


Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg 
385                 390                 395                 400 


Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro 
                405                 410                 415     


Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu 
            420                 425                 430         


Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu 
        435                 440                 445             


Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg 
    450                 455                 460                 


Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr 
465                 470                 475                 480 


Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala 
                485                 490                 495     


Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly 
            500                 505                 510         


Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe 
        515                 520                 525             


His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val 
    530                 535                 540                 


Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile 
545                 550                 555                 560 


Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys 
                565                 570                 575     


His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala 
            580                 585                 590         


Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile 
        595                 600                 605             


Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val 
    610                 615                 620                 


Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val 
625                 630                 635                 640 


Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu 
                645                 650                 655     


His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln 
            660                 665                 670         


Ala Pro Leu Ala Gln 
        675         


<210> 364
<211> 681
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 364
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp Leu Asp 
            100                 105                 110         


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
                165                 170                 175     


Ser Tyr Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
            180                 185                 190         


Trp Val Ala Asp Ile Asn Thr Gly Gly Trp Asn Thr Tyr Tyr Ala Asp 
        195                 200                 205             


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
    210                 215                 220                 


Leu Tyr Leu Glu Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
225                 230                 235                 240 


Tyr Cys Ala Ala Asp Arg Trp Met Val Ala Lys Ile Val Gly Gly Asp 
                245                 250                 255     


Leu Asp Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            260                 265                 270         


Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro 
        275                 280                 285             


Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly 
    290                 295                 300                 


Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg 
305                 310                 315                 320 


Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His 
                325                 330                 335     


Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn 
            340                 345                 350         


Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys 
        355                 360                 365             


Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser 
    370                 375                 380                 


Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu 
385                 390                 395                 400 


Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln 
                405                 410                 415     


Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His 
            420                 425                 430         


Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu 
        435                 440                 445             


Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala 
    450                 455                 460                 


Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser 
465                 470                 475                 480 


Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu 
                485                 490                 495     


Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly 
            500                 505                 510         


Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser 
        515                 520                 525             


Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro 
    530                 535                 540                 


Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala 
545                 550                 555                 560 


Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro 
                565                 570                 575     


Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala 
            580                 585                 590         


His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu 
        595                 600                 605             


Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu 
    610                 615                 620                 


His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp 
625                 630                 635                 640 


Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys 
                645                 650                 655     


Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser 
            660                 665                 670         


Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        675                 680     


<210> 365
<211> 667
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 365
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Phe Ala Phe Gly Ser Tyr Asp Met Ser Trp Val 
                165                 170                 175     


Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Val Ser Ala Ile Thr Pro 
            180                 185                 190         


Gly Gly Gly Gly Thr Phe Tyr Ala Tyr Tyr Ser Asp Ser Val Lys Gly 
        195                 200                 205             


Arg Phe Ala Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Thr Leu Gln 
    210                 215                 220                 


Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
225                 230                 235                 240 


Asn Phe Tyr Gly Asn Gly Gly Arg Gly His Gly Thr Gln Val Thr Val 
                245                 250                 255     


Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser 
            260                 265                 270         


Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu 
        275                 280                 285             


Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu 
    290                 295                 300                 


Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile 
305                 310                 315                 320 


Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser 
                325                 330                 335     


Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro 
            340                 345                 350         


Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe 
        355                 360                 365             


Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala 
    370                 375                 380                 


Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr 
385                 390                 395                 400 


Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu 
                405                 410                 415     


Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu 
            420                 425                 430         


Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys 
        435                 440                 445             


Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys 
    450                 455                 460                 


Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn 
465                 470                 475                 480 


Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr 
                485                 490                 495     


Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr 
            500                 505                 510         


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg 
        515                 520                 525             


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
    530                 535                 540                 


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
545                 550                 555                 560 


Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp 
                565                 570                 575     


Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr 
            580                 585                 590         


Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu 
        595                 600                 605             


Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys 
    610                 615                 620                 


Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu 
625                 630                 635                 640 


Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro 
                645                 650                 655     


Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            660                 665         


<210> 366
<211> 663
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 366
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr His 
            20                  25                  30          


Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ala Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Phe Thr Phe Gly Thr His Ala Met His Trp Val Arg Trp 
                165                 170                 175     


Ala Pro Gly Lys Gly Phe Glu Trp Val Ser Thr Ile Ser Ser Gly Gly 
            180                 185                 190         


Gly Gly Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        195                 200                 205             


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asp Asn Leu Lys 
    210                 215                 220                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ser Pro Ser Asn Ile Ala 
225                 230                 235                 240 


Asn Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser 
                245                 250                 255     


Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser 
            260                 265                 270         


Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser 
        275                 280                 285             


Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp 
    290                 295                 300                 


Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser 
305                 310                 315                 320 


Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly 
                325                 330                 335     


Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe 
            340                 345                 350         


Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile 
        355                 360                 365             


Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala 
    370                 375                 380                 


Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu 
385                 390                 395                 400 


Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala 
                405                 410                 415     


Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys 
            420                 425                 430         


Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys 
        435                 440                 445             


Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu 
    450                 455                 460                 


Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys 
465                 470                 475                 480 


Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn 
                485                 490                 495     


Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu 
            500                 505                 510         


Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val 
        515                 520                 525             


Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala 
    530                 535                 540                 


Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser 
545                 550                 555                 560 


Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe 
                565                 570                 575     


Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala 
            580                 585                 590         


Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe 
        595                 600                 605             


Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp 
    610                 615                 620                 


Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His 
625                 630                 635                 640 


Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp 
                645                 650                 655     


Ala Gln Ala Pro Leu Ala Gln 
            660             


<210> 367
<211> 677
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 367
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Ala 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Arg Thr Phe Gly His Tyr 
                165                 170                 175     


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
            180                 185                 190         


Ala Thr Ile Ser Trp Lys Gly Gly Thr Thr Gly Tyr Ala His Ser Val 
        195                 200                 205             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Ala Lys Asn Met Val Tyr 
    210                 215                 220                 


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Ala Ala Arg Asn Thr Met Ser Gly Ser Met Ser Ser Ser Ala Tyr Pro 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ser Ser Ser 
            260                 265                 270         


Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Pro Pro Ser Phe Ser 
        275                 280                 285             


Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg 
    290                 295                 300                 


Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile 
305                 310                 315                 320 


Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser 
                325                 330                 335     


Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly 
            340                 345                 350         


Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu 
        355                 360                 365             


Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg 
    370                 375                 380                 


Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg 
385                 390                 395                 400 


Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro 
                405                 410                 415     


Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu 
            420                 425                 430         


Gly Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu 
        435                 440                 445             


Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg 
    450                 455                 460                 


Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr 
465                 470                 475                 480 


Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala 
                485                 490                 495     


Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly 
            500                 505                 510         


Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe 
        515                 520                 525             


His Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val 
    530                 535                 540                 


Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile 
545                 550                 555                 560 


Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys 
                565                 570                 575     


His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala 
            580                 585                 590         


Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile 
        595                 600                 605             


Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val 
    610                 615                 620                 


Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val 
625                 630                 635                 640 


Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu 
                645                 650                 655     


His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln 
            660                 665                 670         


Ala Pro Leu Ala Gln 
        675         


<210> 368
<211> 132
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 368
Met Gly Ser His His His His His His Ser Gly Lys Ser Met Asp Glu 
1               5                   10                  15      


Ser Arg Leu Asp Arg Val Lys Glu Tyr Glu Glu Glu Ile His Ser Leu 
            20                  25                  30          


Lys Glu Arg Leu His Met Ser Asn Arg Lys Leu Glu Glu Tyr Glu Arg 
        35                  40                  45              


Arg Leu Leu Ser Gln Glu Glu Gln Thr Ser Lys Ile Leu Met Gln Tyr 
    50                  55                  60                  


Gln Ala Arg Leu Glu Gln Ser Glu Lys Arg Leu Arg Gln Gln Gln Ala 
65                  70                  75                  80  


Glu Lys Asp Ser Gln Ile Lys Ser Ile Ile Gly Arg Leu Met Leu Val 
                85                  90                  95      


Glu Glu Glu Leu Arg Arg Asp His Pro Ala Met Ala Glu Pro Leu Pro 
            100                 105                 110         


Glu Pro Lys Lys Arg Leu Leu Asp Ala Gln Glu Arg Gln Leu Pro Pro 
        115                 120                 125             


Leu Gly Pro Thr 
    130         


<210> 369
<211> 1252
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 369
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Gln Val Gln Leu Val Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Ala Gly Ala Ser Leu Arg Leu Ser Cys Ala Ala 
        595                 600                 605             


Ser Glu Arg Thr Phe Gly His Tyr Ala Met Gly Trp Phe Arg Gln Ala 
    610                 615                 620                 


Pro Gly Lys Glu Arg Glu Phe Val Ala Thr Ile Ser Trp Lys Gly Gly 
625                 630                 635                 640 


Thr Thr Gly Tyr Ala His Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                645                 650                 655     


Asp Ser Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            660                 665                 670         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Asn Thr Met Ser Gly 
        675                 680                 685             


Ser Met Ser Ser Ser Ala Tyr Pro Tyr Trp Gly Gln Gly Thr Gln Val 
    690                 695                 700                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
                725                 730                 735     


Gly Gly Leu Val Gln Ala Gly Ala Ser Leu Arg Leu Ser Cys Ala Ala 
            740                 745                 750         


Ser Glu Arg Thr Phe Gly His Tyr Ala Met Gly Trp Phe Arg Gln Ala 
        755                 760                 765             


Pro Gly Lys Glu Arg Glu Phe Val Ala Thr Ile Ser Trp Lys Gly Gly 
    770                 775                 780                 


Thr Thr Gly Tyr Ala His Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
785                 790                 795                 800 


Asp Ser Ala Lys Asn Met Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
                805                 810                 815     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Asn Thr Met Ser Gly 
            820                 825                 830         


Ser Met Ser Ser Ser Ala Tyr Pro Tyr Trp Gly Gln Gly Thr Gln Val 
        835                 840                 845             


Thr Val Ser Ser Gly Ala Pro Gly Ser Gly Pro Pro Ser Phe Ser Glu 
    850                 855                 860                 


Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu 
865                 870                 875                 880 


Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val 
                885                 890                 895     


Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile 
            900                 905                 910         


Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly 
        915                 920                 925             


Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro 
    930                 935                 940                 


Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp 
945                 950                 955                 960 


Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu 
                965                 970                 975     


Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu 
            980                 985                 990         


Ala Thr Thr Gly Asp Gly Asn Cys  Leu Leu His Ala Ala  Ser Leu Gly 
        995                 1000                 1005             


Met Trp  Gly Phe His Asp Arg  Asp Leu Met Leu Arg  Lys Ala Leu 
    1010                 1015                 1020             


Tyr Ala  Leu Met Glu Lys Gly  Val Glu Lys Glu Ala  Leu Lys Arg 
    1025                 1030                 1035             


Arg Trp  Arg Trp Gln Gln Thr  Gln Gln Asn Lys Glu  Ser Gly Leu 
    1040                 1045                 1050             


Val Tyr  Thr Glu Asp Glu Trp  Gln Lys Glu Trp Asn  Glu Leu Ile 
    1055                 1060                 1065             


Lys Leu  Ala Ser Ser Glu Pro  Arg Met His Leu Gly  Thr Asn Gly 
    1070                 1075                 1080             


Ala Asn  Cys Gly Gly Val Glu  Ser Ser Glu Glu Pro  Val Tyr Glu 
    1085                 1090                 1095             


Ser Leu  Glu Glu Phe His Val  Phe Val Leu Ala His  Val Leu Arg 
    1100                 1105                 1110             


Arg Pro  Ile Val Val Val Ala  Asp Thr Met Leu Arg  Asp Ser Gly 
    1115                 1120                 1125             


Gly Glu  Ala Phe Ala Pro Ile  Pro Phe Gly Gly Ile  Tyr Leu Pro 
    1130                 1135                 1140             


Leu Glu  Val Pro Ala Ser Gln  Cys His Arg Ser Pro  Leu Val Leu 
    1145                 1150                 1155             


Ala Tyr  Asp Gln Ala His Phe  Ser Ala Leu Val Ser  Met Glu Gln 
    1160                 1165                 1170             


Lys Glu  Asn Thr Lys Glu Gln  Ala Val Ile Pro Leu  Thr Asp Ser 
    1175                 1180                 1185             


Glu Tyr  Lys Leu Leu Pro Leu  His Phe Ala Val Asp  Pro Gly Lys 
    1190                 1195                 1200             


Gly Trp  Glu Trp Gly Lys Asp  Asp Ser Asp Asn Val  Arg Leu Ala 
    1205                 1210                 1215             


Ser Val  Ile Leu Ser Leu Glu  Val Lys Leu His Leu  Leu His Ser 
    1220                 1225                 1230             


Tyr Met  Asn Val Lys Trp Ile  Pro Leu Ser Ser Asp  Ala Gln Ala 
    1235                 1240                 1245             


Pro Leu  Ala Gln 
    1250         


<210> 370
<211> 1238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 370
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Gln Val Gln Leu Val Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ala Cys Ala Ala 
        595                 600                 605             


Ser Gly Phe Thr Phe Gly Thr His Ala Met His Trp Val Arg Trp Ala 
    610                 615                 620                 


Pro Gly Lys Gly Phe Glu Trp Val Ser Thr Ile Ser Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                645                 650                 655     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asp Asn Leu Lys Pro 
            660                 665                 670         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Ser Pro Ser Asn Ile Ala Asn 
        675                 680                 685             


Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    690                 695                 700                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
705                 710                 715                 720 


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
                725                 730                 735     


Gly Ser Leu Arg Leu Ala Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr 
            740                 745                 750         


His Ala Met His Trp Val Arg Trp Ala Pro Gly Lys Gly Phe Glu Trp 
        755                 760                 765             


Val Ser Thr Ile Ser Ser Gly Gly Gly Gly Thr Arg Tyr Ala Asp Ser 
    770                 775                 780                 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
785                 790                 795                 800 


Tyr Leu Gln Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
                805                 810                 815     


Cys Asn Ser Pro Ser Asn Ile Ala Asn Asp Asn Trp Gly Gln Gly Thr 
            820                 825                 830         


Gln Val Thr Val Ser Ser Gly Ala Pro Gly Ser Gly Pro Pro Ser Phe 
        835                 840                 845             


Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp 
    850                 855                 860                 


Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp 
865                 870                 875                 880 


Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser 
                885                 890                 895     


Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly 
            900                 905                 910         


Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln 
        915                 920                 925             


Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu 
    930                 935                 940                 


Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly 
945                 950                 955                 960 


Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu 
                965                 970                 975     


Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser 
            980                 985                 990         


Leu Gly Met Trp Gly Phe His Asp  Arg Asp Leu Met Leu  Arg Lys Ala 
        995                 1000                 1005             


Leu Tyr  Ala Leu Met Glu Lys  Gly Val Glu Lys Glu  Ala Leu Lys 
    1010                 1015                 1020             


Arg Arg  Trp Arg Trp Gln Gln  Thr Gln Gln Asn Lys  Glu Ser Gly 
    1025                 1030                 1035             


Leu Val  Tyr Thr Glu Asp Glu  Trp Gln Lys Glu Trp  Asn Glu Leu 
    1040                 1045                 1050             


Ile Lys  Leu Ala Ser Ser Glu  Pro Arg Met His Leu  Gly Thr Asn 
    1055                 1060                 1065             


Gly Ala  Asn Cys Gly Gly Val  Glu Ser Ser Glu Glu  Pro Val Tyr 
    1070                 1075                 1080             


Glu Ser  Leu Glu Glu Phe His  Val Phe Val Leu Ala  His Val Leu 
    1085                 1090                 1095             


Arg Arg  Pro Ile Val Val Val  Ala Asp Thr Met Leu  Arg Asp Ser 
    1100                 1105                 1110             


Gly Gly  Glu Ala Phe Ala Pro  Ile Pro Phe Gly Gly  Ile Tyr Leu 
    1115                 1120                 1125             


Pro Leu  Glu Val Pro Ala Ser  Gln Cys His Arg Ser  Pro Leu Val 
    1130                 1135                 1140             


Leu Ala  Tyr Asp Gln Ala His  Phe Ser Ala Leu Val  Ser Met Glu 
    1145                 1150                 1155             


Gln Lys  Glu Asn Thr Lys Glu  Gln Ala Val Ile Pro  Leu Thr Asp 
    1160                 1165                 1170             


Ser Glu  Tyr Lys Leu Leu Pro  Leu His Phe Ala Val  Asp Pro Gly 
    1175                 1180                 1185             


Lys Gly  Trp Glu Trp Gly Lys  Asp Asp Ser Asp Asn  Val Arg Leu 
    1190                 1195                 1200             


Ala Ser  Val Ile Leu Ser Leu  Glu Val Lys Leu His  Leu Leu His 
    1205                 1210                 1215             


Ser Tyr  Met Asn Val Lys Trp  Ile Pro Leu Ser Ser  Asp Ala Gln 
    1220                 1225                 1230             


Ala Pro  Leu Ala Gln 
    1235             


<210> 371
<211> 1242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 371
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Gln Val Gln Leu Val Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        595                 600                 605             


Ser Gly Phe Ala Phe Gly Ser Tyr Asp Met Ser Trp Val Arg Gln Ala 
    610                 615                 620                 


Pro Gly Gln Gly Pro Glu Trp Val Ser Ala Ile Thr Pro Gly Gly Gly 
625                 630                 635                 640 


Gly Thr Phe Tyr Ala Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Ala 
                645                 650                 655     


Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Thr Leu Gln Met Asn Ser 
            660                 665                 670         


Leu Lys Pro Asp Asp Thr Ala Met Tyr Tyr Cys Ala Lys Asn Phe Tyr 
        675                 680                 685             


Gly Asn Gly Gly Arg Gly His Gly Thr Gln Val Thr Val Ser Ser Gly 
    690                 695                 700                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
705                 710                 715                 720 


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                725                 730                 735     


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe 
            740                 745                 750         


Gly Ser Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro 
        755                 760                 765             


Glu Trp Val Ser Ala Ile Thr Pro Gly Gly Gly Gly Thr Phe Tyr Ala 
    770                 775                 780                 


Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn 
785                 790                 795                 800 


Ala Lys Asn Thr Leu Thr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp 
                805                 810                 815     


Thr Ala Met Tyr Tyr Cys Ala Lys Asn Phe Tyr Gly Asn Gly Gly Arg 
            820                 825                 830         


Gly His Gly Thr Gln Val Thr Val Ser Ser Gly Ala Pro Gly Ser Gly 
        835                 840                 845             


Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
    850                 855                 860                 


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
865                 870                 875                 880 


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
                885                 890                 895     


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
            900                 905                 910         


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
        915                 920                 925             


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
    930                 935                 940                 


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
945                 950                 955                 960 


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
                965                 970                 975     


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
            980                 985                 990         


His Ala Ala Ser Leu Gly Met Trp  Gly Phe His Asp Arg  Asp Leu Met 
        995                 1000                 1005             


Leu Arg  Lys Ala Leu Tyr Ala  Leu Met Glu Lys Gly  Val Glu Lys 
    1010                 1015                 1020             


Glu Ala  Leu Lys Arg Arg Trp  Arg Trp Gln Gln Thr  Gln Gln Asn 
    1025                 1030                 1035             


Lys Glu  Ser Gly Leu Val Tyr  Thr Glu Asp Glu Trp  Gln Lys Glu 
    1040                 1045                 1050             


Trp Asn  Glu Leu Ile Lys Leu  Ala Ser Ser Glu Pro  Arg Met His 
    1055                 1060                 1065             


Leu Gly  Thr Asn Gly Ala Asn  Cys Gly Gly Val Glu  Ser Ser Glu 
    1070                 1075                 1080             


Glu Pro  Val Tyr Glu Ser Leu  Glu Glu Phe His Val  Phe Val Leu 
    1085                 1090                 1095             


Ala His  Val Leu Arg Arg Pro  Ile Val Val Val Ala  Asp Thr Met 
    1100                 1105                 1110             


Leu Arg  Asp Ser Gly Gly Glu  Ala Phe Ala Pro Ile  Pro Phe Gly 
    1115                 1120                 1125             


Gly Ile  Tyr Leu Pro Leu Glu  Val Pro Ala Ser Gln  Cys His Arg 
    1130                 1135                 1140             


Ser Pro  Leu Val Leu Ala Tyr  Asp Gln Ala His Phe  Ser Ala Leu 
    1145                 1150                 1155             


Val Ser  Met Glu Gln Lys Glu  Asn Thr Lys Glu Gln  Ala Val Ile 
    1160                 1165                 1170             


Pro Leu  Thr Asp Ser Glu Tyr  Lys Leu Leu Pro Leu  His Phe Ala 
    1175                 1180                 1185             


Val Asp  Pro Gly Lys Gly Trp  Glu Trp Gly Lys Asp  Asp Ser Asp 
    1190                 1195                 1200             


Asn Val  Arg Leu Ala Ser Val  Ile Leu Ser Leu Glu  Val Lys Leu 
    1205                 1210                 1215             


His Leu  Leu His Ser Tyr Met  Asn Val Lys Trp Ile  Pro Leu Ser 
    1220                 1225                 1230             


Ser Asp  Ala Gln Ala Pro Leu  Ala Gln 
    1235                 1240         


<210> 372
<211> 1256
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 372
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Gln Val Gln Leu Val Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        595                 600                 605             


Ser Gly Phe Ile Phe Ser Ser Tyr Gln Met Ala Trp Val Arg Gln Ala 
    610                 615                 620                 


Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Ile Asn Thr Gly Gly Trp 
625                 630                 635                 640 


Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                645                 650                 655     


Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Asn Ser Leu Lys Pro 
            660                 665                 670         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Arg Trp Met Val Ala 
        675                 680                 685             


Lys Ile Val Gly Gly Asp Leu Asp Phe Asp Ser Trp Gly Gln Gly Thr 
    690                 695                 700                 


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
                725                 730                 735     


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            740                 745                 750         


Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr Gln Met Ala Trp Val Arg 
        755                 760                 765             


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Asp Ile Asn Thr Gly 
    770                 775                 780                 


Gly Trp Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
785                 790                 795                 800 


Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Asn Ser Leu 
                805                 810                 815     


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Arg Trp Met 
            820                 825                 830         


Val Ala Lys Ile Val Gly Gly Asp Leu Asp Phe Asp Ser Trp Gly Gln 
        835                 840                 845             


Gly Thr Gln Val Thr Val Ser Ser Gly Ala Pro Gly Ser Gly Pro Pro 
    850                 855                 860                 


Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe 
865                 870                 875                 880 


Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln 
                885                 890                 895     


Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala 
            900                 905                 910         


Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly 
        915                 920                 925             


Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala 
    930                 935                 940                 


Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe 
945                 950                 955                 960 


Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln 
                965                 970                 975     


Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg 
            980                 985                 990         


Leu Leu Pro Leu Ala Thr Thr Gly  Asp Gly Asn Cys Leu  Leu His Ala 
        995                 1000                 1005             


Ala Ser  Leu Gly Met Trp Gly  Phe His Asp Arg Asp  Leu Met Leu 
    1010                 1015                 1020             


Arg Lys  Ala Leu Tyr Ala Leu  Met Glu Lys Gly Val  Glu Lys Glu 
    1025                 1030                 1035             


Ala Leu  Lys Arg Arg Trp Arg  Trp Gln Gln Thr Gln  Gln Asn Lys 
    1040                 1045                 1050             


Glu Ser  Gly Leu Val Tyr Thr  Glu Asp Glu Trp Gln  Lys Glu Trp 
    1055                 1060                 1065             


Asn Glu  Leu Ile Lys Leu Ala  Ser Ser Glu Pro Arg  Met His Leu 
    1070                 1075                 1080             


Gly Thr  Asn Gly Ala Asn Cys  Gly Gly Val Glu Ser  Ser Glu Glu 
    1085                 1090                 1095             


Pro Val  Tyr Glu Ser Leu Glu  Glu Phe His Val Phe  Val Leu Ala 
    1100                 1105                 1110             


His Val  Leu Arg Arg Pro Ile  Val Val Val Ala Asp  Thr Met Leu 
    1115                 1120                 1125             


Arg Asp  Ser Gly Gly Glu Ala  Phe Ala Pro Ile Pro  Phe Gly Gly 
    1130                 1135                 1140             


Ile Tyr  Leu Pro Leu Glu Val  Pro Ala Ser Gln Cys  His Arg Ser 
    1145                 1150                 1155             


Pro Leu  Val Leu Ala Tyr Asp  Gln Ala His Phe Ser  Ala Leu Val 
    1160                 1165                 1170             


Ser Met  Glu Gln Lys Glu Asn  Thr Lys Glu Gln Ala  Val Ile Pro 
    1175                 1180                 1185             


Leu Thr  Asp Ser Glu Tyr Lys  Leu Leu Pro Leu His  Phe Ala Val 
    1190                 1195                 1200             


Asp Pro  Gly Lys Gly Trp Glu  Trp Gly Lys Asp Asp  Ser Asp Asn 
    1205                 1210                 1215             


Val Arg  Leu Ala Ser Val Ile  Leu Ser Leu Glu Val  Lys Leu His 
    1220                 1225                 1230             


Leu Leu  His Ser Tyr Met Asn  Val Lys Trp Ile Pro  Leu Ser Ser 
    1235                 1240                 1245             


Asp Ala  Gln Ala Pro Leu Ala  Gln 
    1250                 1255     


<210> 373
<211> 1108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 373
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Gln Leu Gln Leu Val Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Glu Ser Leu Arg Leu Ser Cys Ala Ala 
        595                 600                 605             


Ser Gly Phe Thr Phe Ser Asn Tyr Arg Met Tyr Trp Val Arg Met Ala 
    610                 615                 620                 


Pro Gly Lys Gly Leu Glu Trp Val Ser Asp Ile Asp Arg Ser Gly Thr 
625                 630                 635                 640 


Tyr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ala Ile Ser Arg 
                645                 650                 655     


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            660                 665                 670         


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp Arg Arg Leu Ile Val 
        675                 680                 685             


Asp Leu Thr Pro Glu Val Tyr Asp His Trp Gly Gln Gly Thr Gln Val 
    690                 695                 700                 


Thr Val Ser Ser Gly Ala Pro Gly Ser Gly Pro Pro Ser Phe Ser Glu 
705                 710                 715                 720 


Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu 
                725                 730                 735     


Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val 
            740                 745                 750         


Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile 
        755                 760                 765             


Val Ser Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly 
    770                 775                 780                 


Ser Asn Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro 
785                 790                 795                 800 


Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp 
                805                 810                 815     


Leu Ile Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu 
            820                 825                 830         


Asn Trp Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu 
        835                 840                 845             


Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly 
    850                 855                 860                 


Met Trp Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr 
865                 870                 875                 880 


Ala Leu Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp 
                885                 890                 895     


Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr 
            900                 905                 910         


Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser 
        915                 920                 925             


Ser Glu Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly 
    930                 935                 940                 


Val Glu Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His 
945                 950                 955                 960 


Val Phe Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala 
                965                 970                 975     


Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro 
            980                 985                 990         


Phe Gly Gly Ile Tyr Leu Pro Leu  Glu Val Pro Ala Ser  Gln Cys His 
        995                 1000                 1005             


Arg Ser  Pro Leu Val Leu Ala  Tyr Asp Gln Ala His  Phe Ser Ala 
    1010                 1015                 1020             


Leu Val  Ser Met Glu Gln Lys  Glu Asn Thr Lys Glu  Gln Ala Val 
    1025                 1030                 1035             


Ile Pro  Leu Thr Asp Ser Glu  Tyr Lys Leu Leu Pro  Leu His Phe 
    1040                 1045                 1050             


Ala Val  Asp Pro Gly Lys Gly  Trp Glu Trp Gly Lys  Asp Asp Ser 
    1055                 1060                 1065             


Asp Asn  Val Arg Leu Ala Ser  Val Ile Leu Ser Leu  Glu Val Lys 
    1070                 1075                 1080             


Leu His  Leu Leu His Ser Tyr  Met Asn Val Lys Trp  Ile Pro Leu 
    1085                 1090                 1095             


Ser Ser  Asp Ala Gln Ala Pro  Leu Ala Gln 
    1100                 1105             


<210> 374
<211> 1102
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 374
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Gln Val Gln Leu Val Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        595                 600                 605             


Ser Gly Phe Ser Phe Ser Asn Phe Pro Met Met Trp Val Arg Gln Ala 
    610                 615                 620                 


Pro Gly Lys Gly Arg Glu Trp Val Ala Asp Ile Asn Gln Asp Gly Arg 
625                 630                 635                 640 


Asn Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                645                 650                 655     


Asp Asn Ala Lys Thr Thr Val Tyr Leu Gln Met Asn Asn Leu Asn Pro 
            660                 665                 670         


Glu Asp Thr Ala Val Tyr Tyr Cys Gln Ala Ile Arg Thr Thr Thr His 
        675                 680                 685             


Phe Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ala 
    690                 695                 700                 


Pro Gly Ser Gly Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
705                 710                 715                 720 


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
                725                 730                 735     


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
            740                 745                 750         


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
        755                 760                 765             


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
    770                 775                 780                 


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
785                 790                 795                 800 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
                805                 810                 815     


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
            820                 825                 830         


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
        835                 840                 845             


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
    850                 855                 860                 


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
865                 870                 875                 880 


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
                885                 890                 895     


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
            900                 905                 910         


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
        915                 920                 925             


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
    930                 935                 940                 


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
945                 950                 955                 960 


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
                965                 970                 975     


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
            980                 985                 990         


Pro Leu Glu Val Pro Ala Ser Gln  Cys His Arg Ser Pro  Leu Val Leu 
        995                 1000                 1005             


Ala Tyr  Asp Gln Ala His Phe  Ser Ala Leu Val Ser  Met Glu Gln 
    1010                 1015                 1020             


Lys Glu  Asn Thr Lys Glu Gln  Ala Val Ile Pro Leu  Thr Asp Ser 
    1025                 1030                 1035             


Glu Tyr  Lys Leu Leu Pro Leu  His Phe Ala Val Asp  Pro Gly Lys 
    1040                 1045                 1050             


Gly Trp  Glu Trp Gly Lys Asp  Asp Ser Asp Asn Val  Arg Leu Ala 
    1055                 1060                 1065             


Ser Val  Ile Leu Ser Leu Glu  Val Lys Leu His Leu  Leu His Ser 
    1070                 1075                 1080             


Tyr Met  Asn Val Lys Trp Ile  Pro Leu Ser Ser Asp  Ala Gln Ala 
    1085                 1090                 1095             


Pro Leu  Ala Gln 
    1100         


<210> 375
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 375
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 376
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 376
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 377
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 377
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 378
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 378
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 379
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 379
Gly Gly Gly Gly Ser 
1               5   


<210> 380
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 380
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 381
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 381
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210> 382
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 382
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210> 383
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 383
Ser Gly Gly Gly Gly 
1               5   


<210> 384
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 384
Gly Gly Ser Gly Gly 
1               5   


<210> 385
<211> 170
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 385
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
            20                  25                  30          


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
        35                  40                  45              


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
145                 150                 155                 160 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
                165                 170 


<210> 386
<211> 554
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 386
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys 
545                 550                 


<210> 387
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 387
Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu Pro 
1               5                   10                  15  


<210> 388
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 388
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 389
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 389
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 390
<211> 1924
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 390
Met Asp Gly Pro Gly Ala Ser Ala Val Val Val Arg Val Gly Ile Pro 
1               5                   10                  15      


Asp Leu Gln Gln Thr Lys Cys Leu Arg Leu Asp Pro Ala Ala Pro Val 
            20                  25                  30          


Trp Ala Ala Lys Gln Arg Val Leu Cys Ala Leu Asn His Ser Leu Gln 
        35                  40                  45              


Asp Ala Leu Asn Tyr Gly Leu Phe Gln Pro Pro Ser Arg Gly Arg Ala 
    50                  55                  60                  


Gly Lys Phe Leu Asp Glu Glu Arg Leu Leu Gln Glu Tyr Pro Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Pro Leu Pro Tyr Leu Glu Phe Arg Tyr Lys Arg Arg Val 
                85                  90                  95      


Tyr Ala Gln Asn Leu Ile Asp Asp Lys Gln Phe Ala Lys Leu His Thr 
            100                 105                 110         


Lys Ala Asn Leu Lys Lys Phe Met Asp Tyr Val Gln Leu His Ser Thr 
        115                 120                 125             


Asp Lys Val Ala Arg Leu Leu Asp Lys Gly Leu Asp Pro Asn Phe His 
    130                 135                 140                 


Asp Pro Asp Ser Gly Glu Cys Pro Leu Ser Leu Ala Ala Gln Leu Asp 
145                 150                 155                 160 


Asn Ala Thr Asp Leu Leu Lys Val Leu Lys Asn Gly Gly Ala His Leu 
                165                 170                 175     


Asp Phe Arg Thr Arg Asp Gly Leu Thr Ala Val His Cys Ala Thr Arg 
            180                 185                 190         


Gln Arg Asn Ala Ala Ala Leu Thr Thr Leu Leu Asp Leu Gly Ala Ser 
        195                 200                 205             


Pro Asp Tyr Lys Asp Ser Arg Gly Leu Thr Pro Leu Tyr His Ser Ala 
    210                 215                 220                 


Leu Gly Gly Gly Asp Ala Leu Cys Cys Glu Leu Leu Leu His Asp His 
225                 230                 235                 240 


Ala Gln Leu Gly Ile Thr Asp Glu Asn Gly Trp Gln Glu Ile His Gln 
                245                 250                 255     


Ala Cys Arg Phe Gly His Val Gln His Leu Glu His Leu Leu Phe Tyr 
            260                 265                 270         


Gly Ala Asp Met Gly Ala Gln Asn Ala Ser Gly Asn Thr Ala Leu His 
        275                 280                 285             


Ile Cys Ala Leu Tyr Asn Gln Glu Ser Cys Ala Arg Val Leu Leu Phe 
    290                 295                 300                 


Arg Gly Ala Asn Arg Asp Val Arg Asn Tyr Asn Ser Gln Thr Ala Phe 
305                 310                 315                 320 


Gln Val Ala Ile Ile Ala Gly Asn Phe Glu Leu Ala Glu Val Ile Lys 
                325                 330                 335     


Thr His Lys Asp Ser Asp Val Val Pro Phe Arg Glu Thr Pro Ser Tyr 
            340                 345                 350         


Ala Lys Arg Arg Arg Leu Ala Gly Pro Ser Gly Leu Ala Ser Pro Arg 
        355                 360                 365             


Pro Leu Gln Arg Ser Ala Ser Asp Ile Asn Leu Lys Gly Glu Ala Gln 
    370                 375                 380                 


Pro Ala Ala Ser Pro Gly Pro Ser Leu Arg Ser Leu Pro His Gln Leu 
385                 390                 395                 400 


Leu Leu Gln Arg Leu Gln Glu Glu Lys Asp Arg Asp Arg Asp Ala Asp 
                405                 410                 415     


Gln Glu Ser Asn Ile Ser Gly Pro Leu Ala Gly Arg Ala Gly Gln Ser 
            420                 425                 430         


Lys Ile Ser Pro Ser Gly Pro Gly Gly Pro Gly Pro Ala Pro Gly Pro 
        435                 440                 445             


Gly Pro Ala Pro Pro Ala Pro Pro Ala Pro Pro Pro Arg Gly Pro Lys 
    450                 455                 460                 


Arg Lys Leu Tyr Ser Ala Val Pro Gly Arg Lys Phe Ile Ala Val Lys 
465                 470                 475                 480 


Ala His Ser Pro Gln Gly Glu Gly Glu Ile Pro Leu His Arg Gly Glu 
                485                 490                 495     


Ala Val Lys Val Leu Ser Ile Gly Glu Gly Gly Phe Trp Glu Gly Thr 
            500                 505                 510         


Val Lys Gly Arg Thr Gly Trp Phe Pro Ala Asp Cys Val Glu Glu Val 
        515                 520                 525             


Gln Met Arg Gln His Asp Thr Arg Pro Glu Thr Arg Glu Asp Arg Thr 
    530                 535                 540                 


Lys Arg Leu Phe Arg His Tyr Thr Val Gly Ser Tyr Asp Ser Leu Thr 
545                 550                 555                 560 


Ser His Ser Asp Tyr Val Ile Asp Asp Lys Val Ala Val Leu Gln Lys 
                565                 570                 575     


Arg Asp His Glu Gly Phe Gly Phe Val Leu Arg Gly Ala Lys Ala Glu 
            580                 585                 590         


Thr Pro Ile Glu Glu Phe Thr Pro Thr Pro Ala Phe Pro Ala Leu Gln 
        595                 600                 605             


Tyr Leu Glu Ser Val Asp Val Glu Gly Val Ala Trp Arg Ala Gly Leu 
    610                 615                 620                 


Arg Thr Gly Asp Phe Leu Ile Glu Val Asn Gly Val Asn Val Val Lys 
625                 630                 635                 640 


Val Gly His Lys Gln Val Val Ala Leu Ile Arg Gln Gly Gly Asn Arg 
                645                 650                 655     


Leu Val Met Lys Val Val Ser Val Thr Arg Lys Pro Glu Glu Asp Gly 
            660                 665                 670         


Ala Arg Arg Arg Ala Pro Pro Pro Pro Lys Arg Ala Pro Ser Thr Thr 
        675                 680                 685             


Leu Thr Leu Arg Ser Lys Ser Met Thr Ala Glu Leu Glu Glu Leu Ala 
    690                 695                 700                 


Ser Ile Arg Arg Arg Lys Gly Glu Lys Leu Asp Glu Met Leu Ala Ala 
705                 710                 715                 720 


Ala Ala Glu Pro Thr Leu Arg Pro Asp Ile Ala Asp Ala Asp Ser Arg 
                725                 730                 735     


Ala Ala Thr Val Lys Gln Arg Pro Thr Ser Arg Arg Ile Thr Pro Ala 
            740                 745                 750         


Glu Ile Ser Ser Leu Phe Glu Arg Gln Gly Leu Pro Gly Pro Glu Lys 
        755                 760                 765             


Leu Pro Gly Ser Leu Arg Lys Gly Ile Pro Arg Thr Lys Ser Val Gly 
    770                 775                 780                 


Glu Asp Glu Lys Leu Ala Ser Leu Leu Glu Gly Arg Phe Pro Arg Ser 
785                 790                 795                 800 


Thr Ser Met Gln Asp Pro Val Arg Glu Gly Arg Gly Ile Pro Pro Pro 
                805                 810                 815     


Pro Gln Thr Ala Pro Pro Pro Pro Pro Ala Pro Tyr Tyr Phe Asp Ser 
            820                 825                 830         


Gly Pro Pro Pro Ala Phe Ser Pro Pro Pro Pro Pro Gly Arg Ala Tyr 
        835                 840                 845             


Asp Thr Val Arg Ser Ser Phe Lys Pro Gly Leu Glu Ala Arg Leu Gly 
    850                 855                 860                 


Ala Gly Ala Ala Gly Leu Tyr Glu Pro Gly Ala Ala Leu Gly Pro Leu 
865                 870                 875                 880 


Pro Tyr Pro Glu Arg Gln Lys Arg Ala Arg Ser Met Ile Ile Leu Gln 
                885                 890                 895     


Asp Ser Ala Pro Glu Ser Gly Asp Ala Pro Arg Pro Pro Pro Ala Ala 
            900                 905                 910         


Thr Pro Pro Glu Arg Pro Lys Arg Arg Pro Arg Pro Pro Gly Pro Asp 
        915                 920                 925             


Ser Pro Tyr Ala Asn Leu Gly Ala Phe Ser Ala Ser Leu Phe Ala Pro 
    930                 935                 940                 


Ser Lys Pro Gln Arg Arg Lys Ser Pro Leu Val Lys Gln Leu Gln Val 
945                 950                 955                 960 


Glu Asp Ala Gln Glu Arg Ala Ala Leu Ala Val Gly Ser Pro Gly Pro 
                965                 970                 975     


Gly Gly Gly Ser Phe Ala Arg Glu Pro Ser Pro Thr His Arg Gly Pro 
            980                 985                 990         


Arg Pro Gly Gly Leu Asp Tyr Gly  Ala Gly Asp Gly Pro  Gly Leu Ala 
        995                 1000                 1005             


Phe Gly  Gly Pro Gly Pro Ala  Lys Asp Arg Arg Leu  Glu Glu Arg 
    1010                 1015                 1020             


Arg Arg  Ser Thr Val Phe Leu  Ser Val Gly Ala Ile  Glu Gly Ser 
    1025                 1030                 1035             


Ala Pro  Gly Ala Asp Leu Pro  Ser Leu Gln Pro Ser  Arg Ser Ile 
    1040                 1045                 1050             


Asp Glu  Arg Leu Leu Gly Thr  Gly Pro Thr Ala Gly  Arg Asp Leu 
    1055                 1060                 1065             


Leu Leu  Pro Ser Pro Val Ser  Ala Leu Lys Pro Leu  Val Ser Gly 
    1070                 1075                 1080             


Pro Ser  Leu Gly Pro Ser Gly  Ser Thr Phe Ile His  Pro Leu Thr 
    1085                 1090                 1095             


Gly Lys  Pro Leu Asp Pro Ser  Ser Pro Leu Ala Leu  Ala Leu Ala 
    1100                 1105                 1110             


Ala Arg  Glu Arg Ala Leu Ala  Ser Gln Ala Pro Ser  Arg Ser Pro 
    1115                 1120                 1125             


Thr Pro  Val His Ser Pro Asp  Ala Asp Arg Pro Gly  Pro Leu Phe 
    1130                 1135                 1140             


Val Asp  Val Gln Ala Arg Asp  Pro Glu Arg Gly Ser  Leu Ala Ser 
    1145                 1150                 1155             


Pro Ala  Phe Ser Pro Arg Ser  Pro Ala Trp Ile Pro  Val Pro Ala 
    1160                 1165                 1170             


Arg Arg  Glu Ala Glu Lys Val  Pro Arg Glu Glu Arg  Lys Ser Pro 
    1175                 1180                 1185             


Glu Asp  Lys Lys Ser Met Ile  Leu Ser Val Leu Asp  Thr Ser Leu 
    1190                 1195                 1200             


Gln Arg  Pro Ala Gly Leu Ile  Val Val His Ala Thr  Ser Asn Gly 
    1205                 1210                 1215             


Gln Glu  Pro Ser Arg Leu Gly  Gly Ala Glu Glu Glu  Arg Pro Gly 
    1220                 1225                 1230             


Thr Pro  Glu Leu Ala Pro Ala  Pro Met Gln Ser Ala  Ala Val Ala 
    1235                 1240                 1245             


Glu Pro  Leu Pro Ser Pro Arg  Ala Gln Pro Pro Gly  Gly Thr Pro 
    1250                 1255                 1260             


Ala Asp  Ala Gly Pro Gly Gln  Gly Ser Ser Glu Glu  Glu Pro Glu 
    1265                 1270                 1275             


Leu Val  Phe Ala Val Asn Leu  Pro Pro Ala Gln Leu  Ser Ser Ser 
    1280                 1285                 1290             


Asp Glu  Glu Thr Arg Glu Glu  Leu Ala Arg Ile Gly  Leu Val Pro 
    1295                 1300                 1305             


Pro Pro  Glu Glu Phe Ala Asn  Gly Val Leu Leu Ala  Thr Pro Leu 
    1310                 1315                 1320             


Ala Gly  Pro Gly Pro Ser Pro  Thr Thr Val Pro Ser  Pro Ala Ser 
    1325                 1330                 1335             


Gly Lys  Pro Ser Ser Glu Pro  Pro Pro Ala Pro Glu  Ser Ala Ala 
    1340                 1345                 1350             


Asp Ser  Gly Val Glu Glu Ala  Asp Thr Arg Ser Ser  Ser Asp Pro 
    1355                 1360                 1365             


His Leu  Glu Thr Thr Ser Thr  Ile Ser Thr Val Ser  Ser Met Ser 
    1370                 1375                 1380             


Thr Leu  Ser Ser Glu Ser Gly  Glu Leu Thr Asp Thr  His Thr Ser 
    1385                 1390                 1395             


Phe Ala  Asp Gly His Thr Phe  Leu Leu Glu Lys Pro  Pro Val Pro 
    1400                 1405                 1410             


Pro Lys  Pro Lys Leu Lys Ser  Pro Leu Gly Lys Gly  Pro Val Thr 
    1415                 1420                 1425             


Phe Arg  Asp Pro Leu Leu Lys  Gln Ser Ser Asp Ser  Glu Leu Met 
    1430                 1435                 1440             


Ala Gln  Gln His His Ala Ala  Ser Ala Gly Leu Ala  Ser Ala Ala 
    1445                 1450                 1455             


Gly Pro  Ala Arg Pro Arg Tyr  Leu Phe Gln Arg Arg  Ser Lys Leu 
    1460                 1465                 1470             


Trp Gly  Asp Pro Val Glu Ser  Arg Gly Leu Pro Gly  Pro Glu Asp 
    1475                 1480                 1485             


Asp Lys  Pro Thr Val Ile Ser  Glu Leu Ser Ser Arg  Leu Gln Gln 
    1490                 1495                 1500             


Leu Asn  Lys Asp Thr Arg Ser  Leu Gly Glu Glu Pro  Val Gly Gly 
    1505                 1510                 1515             


Leu Gly  Ser Leu Leu Asp Pro  Ala Lys Lys Ser Pro  Ile Ala Ala 
    1520                 1525                 1530             


Ala Arg  Leu Phe Ser Ser Leu  Gly Glu Leu Ser Ser  Ile Ser Ala 
    1535                 1540                 1545             


Gln Arg  Ser Pro Gly Gly Pro  Gly Gly Gly Ala Ser  Tyr Ser Val 
    1550                 1555                 1560             


Arg Pro  Ser Gly Arg Tyr Pro  Val Ala Arg Arg Ala  Pro Ser Pro 
    1565                 1570                 1575             


Val Lys  Pro Ala Ser Leu Glu  Arg Val Glu Gly Leu  Gly Ala Gly 
    1580                 1585                 1590             


Ala Gly  Gly Ala Gly Arg Pro  Phe Gly Leu Thr Pro  Pro Thr Ile 
    1595                 1600                 1605             


Leu Lys  Ser Ser Ser Leu Ser  Ile Pro His Glu Pro  Lys Glu Val 
    1610                 1615                 1620             


Arg Phe  Val Val Arg Ser Val  Ser Ala Arg Ser Arg  Ser Pro Ser 
    1625                 1630                 1635             


Pro Ser  Pro Leu Pro Ser Pro  Ala Ser Gly Pro Gly  Pro Gly Ala 
    1640                 1645                 1650             


Pro Gly  Pro Arg Arg Pro Phe  Gln Gln Lys Pro Leu  Gln Leu Trp 
    1655                 1660                 1665             


Ser Lys  Phe Asp Val Gly Asp  Trp Leu Glu Ser Ile  His Leu Gly 
    1670                 1675                 1680             


Glu His  Arg Asp Arg Phe Glu  Asp His Glu Ile Glu  Gly Ala His 
    1685                 1690                 1695             


Leu Pro  Ala Leu Thr Lys Asp  Asp Phe Val Glu Leu  Gly Val Thr 
    1700                 1705                 1710             


Arg Val  Gly His Arg Met Asn  Ile Glu Arg Ala Leu  Arg Gln Leu 
    1715                 1720                 1725             


Asp Gly  Ser Lys Val Pro Val  Phe Thr Leu Glu Asp  Phe Val Gly 
    1730                 1735                 1740             


Asp Trp  Arg Gln Thr Ala Gly  Tyr Asn Leu Asp Gln  Val Leu Glu 
    1745                 1750                 1755             


Gln Gly  Gly Val Ser Ser Leu  Phe Gln Asn Leu Gly  Val Ser Val 
    1760                 1765                 1770             


Thr Pro  Ile Gln Arg Ile Val  Leu Ser Gly Glu Asn  Gly Leu Lys 
    1775                 1780                 1785             


Ile Asp  Ile His Val Ile Ile  Pro Tyr Glu Gly Leu  Ser Gly Asp 
    1790                 1795                 1800             


Gln Met  Gly Gln Ile Glu Lys  Ile Phe Lys Val Val  Tyr Pro Val 
    1805                 1810                 1815             


Asp Asp  His His Phe Lys Val  Ile Leu His Tyr Gly  Thr Leu Val 
    1820                 1825                 1830             


Ile Asp  Gly Val Thr Pro Asn  Met Ile Asp Tyr Phe  Gly Arg Pro 
    1835                 1840                 1845             


Tyr Glu  Gly Ile Ala Val Phe  Asp Gly Lys Lys Ile  Thr Val Thr 
    1850                 1855                 1860             


Gly Thr  Leu Trp Asn Gly Asn  Lys Ile Ile Asp Glu  Arg Leu Ile 
    1865                 1870                 1875             


Asn Pro  Asp Gly Ser Leu Leu  Phe Arg Val Thr Ile  Asn Gly Val 
    1880                 1885                 1890             


Thr Gly  Trp Arg Leu Cys Glu  Arg Ile Leu Ala Gly  Gly Gly Gly 
    1895                 1900                 1905             


Ser Pro  Ser Arg Leu Glu Glu  Glu Leu Arg Arg Arg  Leu Thr Glu 
    1910                 1915                 1920             


Pro 
    


<210> 391
<211> 1153
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 391
Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
            900                 905                 910         


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
        915                 920                 925             


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
    930                 935                 940                 


Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 960 


Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 
                965                 970                 975     


Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 
            980                 985                 990         


Ser Leu Phe Gln Asn Leu Gly Val  Ser Val Thr Pro Ile  Gln Arg Ile 
        995                 1000                 1005             


Val Leu  Ser Gly Glu Asn Gly  Leu Lys Ile Asp Ile  His Val Ile 
    1010                 1015                 1020             


Ile Pro  Tyr Glu Gly Leu Ser  Gly Asp Gln Met Gly  Gln Ile Glu 
    1025                 1030                 1035             


Lys Ile  Phe Lys Val Val Tyr  Pro Val Asp Asp His  His Phe Lys 
    1040                 1045                 1050             


Val Ile  Leu His Tyr Gly Thr  Leu Val Ile Asp Gly  Val Thr Pro 
    1055                 1060                 1065             


Asn Met  Ile Asp Tyr Phe Gly  Arg Pro Tyr Glu Gly  Ile Ala Val 
    1070                 1075                 1080             


Phe Asp  Gly Lys Lys Ile Thr  Val Thr Gly Thr Leu  Trp Asn Gly 
    1085                 1090                 1095             


Asn Lys  Ile Ile Asp Glu Arg  Leu Ile Asn Pro Asp  Gly Ser Leu 
    1100                 1105                 1110             


Leu Phe  Arg Val Thr Ile Asn  Gly Val Thr Gly Trp  Arg Leu Cys 
    1115                 1120                 1125             


Glu Arg  Ile Leu Ala Gly Gly  Gly Gly Ser Pro Ser  Arg Leu Glu 
    1130                 1135                 1140             


Glu Glu  Leu Arg Arg Arg Leu  Thr Glu Pro 
    1145                 1150             


<210> 392
<211> 787
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 392
Met Ala Pro Ile Gly Leu Lys Ala Val Val Gly Glu Lys Ile Met His 
1               5                   10                  15      


Asp Val Ile Lys Lys Val Lys Lys Lys Gly Glu Trp Lys Val Leu Val 
            20                  25                  30          


Val Asp Gln Leu Ser Met Arg Met Leu Ser Ser Cys Cys Lys Met Thr 
        35                  40                  45              


Asp Ile Met Thr Glu Gly Ile Thr Ile Val Glu Asp Ile Asn Lys Arg 
    50                  55                  60                  


Arg Glu Pro Leu Pro Ser Leu Glu Ala Val Tyr Leu Ile Thr Pro Ser 
65                  70                  75                  80  


Glu Lys Ser Val His Ser Leu Ile Ser Asp Phe Lys Asp Pro Pro Thr 
                85                  90                  95      


Ala Lys Tyr Arg Ala Ala His Val Phe Phe Thr Asp Ser Cys Pro Asp 
            100                 105                 110         


Ala Leu Phe Asn Glu Leu Val Lys Ser Arg Ala Ala Lys Val Ile Lys 
        115                 120                 125             


Thr Leu Thr Glu Ile Asn Ile Ala Phe Leu Pro Tyr Glu Ser Gln Val 
    130                 135                 140                 


Tyr Ser Leu Asp Ser Ala Asp Ser Phe Gln Ser Phe Tyr Ser Pro His 
145                 150                 155                 160 


Lys Ala Gln Met Lys Asn Pro Ile Leu Glu Arg Leu Ala Glu Gln Ile 
                165                 170                 175     


Ala Thr Leu Cys Ala Thr Leu Lys Glu Tyr Pro Ala Val Arg Tyr Arg 
            180                 185                 190         


Gly Glu Tyr Lys Asp Asn Ala Leu Leu Ala Gln Leu Ile Gln Asp Lys 
        195                 200                 205             


Leu Asp Ala Tyr Lys Ala Asp Asp Pro Thr Met Gly Glu Gly Pro Asp 
    210                 215                 220                 


Lys Ala Arg Ser Gln Leu Leu Ile Leu Asp Arg Gly Phe Asp Pro Ser 
225                 230                 235                 240 


Ser Pro Val Leu His Glu Leu Thr Phe Gln Ala Met Ser Tyr Asp Leu 
                245                 250                 255     


Leu Pro Ile Glu Asn Asp Val Tyr Lys Tyr Glu Thr Ser Gly Ile Gly 
            260                 265                 270         


Glu Ala Arg Val Lys Glu Val Leu Leu Asp Glu Asp Asp Asp Leu Trp 
        275                 280                 285             


Ile Ala Leu Arg His Lys His Ile Ala Glu Val Ser Gln Glu Val Thr 
    290                 295                 300                 


Arg Ser Leu Lys Asp Phe Ser Ser Ser Lys Arg Met Asn Thr Gly Glu 
305                 310                 315                 320 


Lys Thr Thr Met Arg Asp Leu Ser Gln Met Leu Lys Lys Met Pro Gln 
                325                 330                 335     


Tyr Gln Lys Glu Leu Ser Lys Tyr Ser Thr His Leu His Leu Ala Glu 
            340                 345                 350         


Asp Cys Met Lys His Tyr Gln Gly Thr Val Asp Lys Leu Cys Arg Val 
        355                 360                 365             


Glu Gln Asp Leu Ala Met Gly Thr Asp Ala Glu Gly Glu Lys Ile Lys 
    370                 375                 380                 


Asp Pro Met Arg Ala Ile Val Pro Ile Leu Leu Asp Ala Asn Val Ser 
385                 390                 395                 400 


Thr Tyr Asp Lys Ile Arg Ile Ile Leu Leu Tyr Ile Phe Leu Lys Asn 
                405                 410                 415     


Gly Ile Thr Glu Glu Asn Leu Asn Lys Leu Ile Gln His Ala Gln Ile 
            420                 425                 430         


Pro Pro Glu Asp Ser Glu Ile Ile Thr Asn Met Ala His Leu Gly Val 
        435                 440                 445             


Pro Ile Val Thr Asp Ser Thr Leu Arg Arg Arg Ser Lys Pro Glu Arg 
    450                 455                 460                 


Lys Glu Arg Ile Ser Glu Gln Thr Tyr Gln Leu Ser Arg Trp Thr Pro 
465                 470                 475                 480 


Ile Ile Lys Asp Ile Met Glu Asp Thr Ile Glu Asp Lys Leu Asp Thr 
                485                 490                 495     


Lys His Tyr Pro Tyr Ile Ser Thr Arg Ser Ser Ala Ser Phe Ser Thr 
            500                 505                 510         


Thr Ala Val Ser Ala Arg Tyr Gly His Trp His Lys Asn Lys Ala Pro 
        515                 520                 525             


Gly Glu Tyr Arg Ser Gly Pro Arg Leu Ile Ile Phe Ile Leu Gly Gly 
    530                 535                 540                 


Val Ser Leu Asn Glu Met Arg Cys Ala Tyr Glu Val Thr Gln Ala Asn 
545                 550                 555                 560 


Gly Lys Trp Glu Val Leu Ile Gly Ser Thr His Ile Leu Thr Pro Gln 
                565                 570                 575     


Lys Leu Leu Asp Thr Leu Lys Lys Leu Asn Lys Thr Asp Glu Glu Ile 
            580                 585                 590         


Ser Ser Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp 
        595                 600                 605             


Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly 
    610                 615                 620                 


Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln 
625                 630                 635                 640 


Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val 
                645                 650                 655     


Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu 
            660                 665                 670         


Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val 
        675                 680                 685             


Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met 
    690                 695                 700                 


Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly 
705                 710                 715                 720 


Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile 
                725                 730                 735     


Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr 
            740                 745                 750         


Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly 
        755                 760                 765             


Gly Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu 
    770                 775                 780                 


Thr Glu Pro 
785         


<210> 393
<211> 1057
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 393
Met Gly Asn Arg Gly Met Glu Asp Leu Ile Pro Leu Val Asn Arg Leu 
1               5                   10                  15      


Gln Asp Ala Phe Ser Ala Ile Gly Gln Asn Ala Asp Leu Asp Leu Pro 
            20                  25                  30          


Gln Ile Ala Val Val Gly Gly Gln Ser Ala Gly Lys Ser Ser Val Leu 
        35                  40                  45              


Glu Asn Phe Val Gly Arg Asp Phe Leu Pro Arg Gly Ser Gly Ile Val 
    50                  55                  60                  


Thr Arg Arg Pro Leu Val Leu Gln Leu Val Asn Ala Thr Thr Glu Tyr 
65                  70                  75                  80  


Ala Glu Phe Leu His Cys Lys Gly Lys Lys Phe Thr Asp Phe Glu Glu 
                85                  90                  95      


Val Arg Leu Glu Ile Glu Ala Glu Thr Asp Arg Val Thr Gly Thr Asn 
            100                 105                 110         


Lys Gly Ile Ser Pro Val Pro Ile Asn Leu Arg Val Tyr Ser Pro His 
        115                 120                 125             


Val Leu Asn Leu Thr Leu Val Asp Leu Pro Gly Met Thr Lys Val Pro 
    130                 135                 140                 


Val Gly Asp Gln Pro Pro Asp Ile Glu Phe Gln Ile Arg Asp Met Leu 
145                 150                 155                 160 


Met Gln Phe Val Thr Lys Glu Asn Cys Leu Ile Leu Ala Val Ser Pro 
                165                 170                 175     


Ala Asn Ser Asp Leu Ala Asn Ser Asp Ala Leu Lys Val Ala Lys Glu 
            180                 185                 190         


Val Asp Pro Gln Gly Gln Arg Thr Ile Gly Val Ile Thr Lys Leu Asp 
        195                 200                 205             


Leu Met Asp Glu Gly Thr Asp Ala Arg Asp Val Leu Glu Asn Lys Leu 
    210                 215                 220                 


Leu Pro Leu Arg Arg Gly Tyr Ile Gly Val Val Asn Arg Ser Gln Lys 
225                 230                 235                 240 


Asp Ile Asp Gly Lys Lys Asp Ile Thr Ala Ala Leu Ala Ala Glu Arg 
                245                 250                 255     


Lys Phe Phe Leu Ser His Pro Ser Tyr Arg His Leu Ala Asp Arg Met 
            260                 265                 270         


Gly Thr Pro Tyr Leu Gln Lys Val Leu Asn Gln Gln Leu Thr Asn His 
        275                 280                 285             


Ile Arg Asp Thr Leu Pro Gly Leu Arg Asn Lys Leu Gln Ser Gln Leu 
    290                 295                 300                 


Leu Ser Ile Glu Lys Glu Val Glu Glu Tyr Lys Asn Phe Arg Pro Asp 
305                 310                 315                 320 


Asp Pro Ala Arg Lys Thr Lys Ala Leu Leu Gln Met Val Gln Gln Phe 
                325                 330                 335     


Ala Val Asp Phe Glu Lys Arg Ile Glu Gly Ser Gly Asp Gln Ile Asp 
            340                 345                 350         


Thr Tyr Glu Leu Ser Gly Gly Ala Arg Ile Asn Arg Ile Phe His Glu 
        355                 360                 365             


Arg Phe Pro Phe Glu Leu Val Lys Met Glu Phe Asp Glu Lys Glu Leu 
    370                 375                 380                 


Arg Arg Glu Ile Ser Tyr Ala Ile Lys Asn Ile His Gly Ile Arg Thr 
385                 390                 395                 400 


Gly Leu Phe Thr Pro Asp Met Ala Phe Glu Thr Ile Val Lys Lys Gln 
                405                 410                 415     


Val Lys Lys Ile Arg Glu Pro Cys Leu Lys Cys Val Asp Met Val Ile 
            420                 425                 430         


Ser Glu Leu Ile Ser Thr Val Arg Gln Cys Thr Lys Lys Leu Gln Gln 
        435                 440                 445             


Tyr Pro Arg Leu Arg Glu Glu Met Glu Arg Ile Val Thr Thr His Ile 
    450                 455                 460                 


Arg Glu Arg Glu Gly Arg Thr Lys Glu Gln Val Met Leu Leu Ile Asp 
465                 470                 475                 480 


Ile Glu Leu Ala Tyr Met Asn Thr Asn His Glu Asp Phe Ile Gly Phe 
                485                 490                 495     


Ala Asn Ala Gln Gln Arg Ser Asn Gln Met Asn Lys Lys Lys Thr Ser 
            500                 505                 510         


Gly Asn Gln Asp Glu Ile Leu Val Ile Arg Lys Gly Trp Leu Thr Ile 
        515                 520                 525             


Asn Asn Ile Gly Ile Met Lys Gly Gly Ser Lys Glu Tyr Trp Phe Val 
    530                 535                 540                 


Leu Thr Ala Glu Asn Leu Ser Trp Tyr Lys Asp Asp Glu Glu Lys Glu 
545                 550                 555                 560 


Lys Lys Tyr Met Leu Ser Val Asp Asn Leu Lys Leu Arg Asp Val Glu 
                565                 570                 575     


Lys Gly Phe Met Ser Ser Lys His Ile Phe Ala Leu Phe Asn Thr Glu 
            580                 585                 590         


Gln Arg Asn Val Tyr Lys Asp Tyr Arg Gln Leu Glu Leu Ala Cys Glu 
        595                 600                 605             


Thr Gln Glu Glu Val Asp Ser Trp Lys Ala Ser Phe Leu Arg Ala Gly 
    610                 615                 620                 


Val Tyr Pro Glu Arg Val Gly Asp Lys Glu Lys Ala Ser Glu Thr Glu 
625                 630                 635                 640 


Glu Asn Gly Ser Asp Ser Phe Met His Ser Met Asp Pro Gln Leu Glu 
                645                 650                 655     


Arg Gln Val Glu Thr Ile Arg Asn Leu Val Asp Ser Tyr Met Ala Ile 
            660                 665                 670         


Val Asn Lys Thr Val Arg Asp Leu Met Pro Lys Thr Ile Met His Leu 
        675                 680                 685             


Met Ile Asn Asn Thr Lys Glu Phe Ile Phe Ser Glu Leu Leu Ala Asn 
    690                 695                 700                 


Leu Tyr Ser Cys Gly Asp Gln Asn Thr Leu Met Glu Glu Ser Ala Glu 
705                 710                 715                 720 


Gln Ala Gln Arg Arg Asp Glu Met Leu Arg Met Tyr His Ala Leu Lys 
                725                 730                 735     


Glu Ala Leu Ser Ile Ile Gly Asp Ile Asn Thr Thr Thr Val Ser Thr 
            740                 745                 750         


Pro Met Pro Pro Pro Val Asp Asp Ser Trp Leu Gln Val Gln Ser Val 
        755                 760                 765             


Pro Ala Gly Arg Arg Ser Pro Thr Ser Ser Pro Thr Pro Gln Arg Arg 
    770                 775                 780                 


Ala Pro Ala Val Pro Pro Ala Arg Pro Gly Ser Arg Gly Pro Ala Pro 
785                 790                 795                 800 


Gly Pro Pro Pro Ala Gly Ser Ala Leu Gly Gly Ala Pro Pro Val Pro 
                805                 810                 815     


Ser Arg Pro Gly Ala Ser Pro Asp Pro Phe Gly Pro Pro Pro Gln Val 
            820                 825                 830         


Pro Ser Arg Pro Asn Arg Ala Pro Pro Gly Val Pro Ser Arg Ser Gly 
        835                 840                 845             


Gln Ala Ser Pro Ser Arg Pro Glu Ser Pro Arg Pro Pro Phe Asp Leu 
    850                 855                 860                 


Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 
865                 870                 875                 880 


Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 
                885                 890                 895     


Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 
            900                 905                 910         


Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 
        915                 920                 925             


Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 
    930                 935                 940                 


Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 
945                 950                 955                 960 


His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 
                965                 970                 975     


Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 
            980                 985                 990         


Ile Thr Val Thr Gly Thr Leu Trp  Asn Gly Asn Lys Ile  Ile Asp Glu 
        995                 1000                 1005             


Arg Leu  Ile Asn Pro Asp Gly  Ser Leu Leu Phe Arg  Val Thr Ile 
    1010                 1015                 1020             


Asn Gly  Val Thr Gly Trp Arg  Leu Cys Glu Arg Ile  Leu Ala Gly 
    1025                 1030                 1035             


Gly Gly  Gly Ser Pro Ser Arg  Leu Glu Glu Glu Leu  Arg Arg Arg 
    1040                 1045                 1050             


Leu Thr  Glu Pro 
    1055         


<210> 394
<211> 1883
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 394
Met Ala Gly Ala Ser Val Lys Val Ala Val Arg Val Arg Pro Phe Asn 
1               5                   10                  15      


Ser Arg Glu Met Ser Arg Asp Ser Lys Cys Ile Ile Gln Met Ser Gly 
            20                  25                  30          


Ser Thr Thr Thr Ile Val Asn Pro Lys Gln Pro Lys Glu Thr Pro Lys 
        35                  40                  45              


Ser Phe Ser Phe Asp Tyr Ser Tyr Trp Ser His Thr Ser Pro Glu Asp 
    50                  55                  60                  


Ile Asn Tyr Ala Ser Gln Lys Gln Val Tyr Arg Asp Ile Gly Glu Glu 
65                  70                  75                  80  


Met Leu Gln His Ala Phe Glu Gly Tyr Asn Val Cys Ile Phe Ala Tyr 
                85                  90                  95      


Gly Gln Thr Gly Ala Gly Lys Ser Tyr Thr Met Met Gly Lys Gln Glu 
            100                 105                 110         


Lys Asp Gln Gln Gly Ile Ile Pro Gln Leu Cys Glu Asp Leu Phe Ser 
        115                 120                 125             


Arg Ile Asn Asp Thr Thr Asn Asp Asn Met Ser Tyr Ser Val Glu Val 
    130                 135                 140                 


Ser Tyr Met Glu Ile Tyr Cys Glu Arg Val Arg Asp Leu Leu Asn Pro 
145                 150                 155                 160 


Lys Asn Lys Gly Asn Leu Arg Val Arg Glu His Pro Leu Leu Gly Pro 
                165                 170                 175     


Tyr Val Glu Asp Leu Ser Lys Leu Ala Val Thr Ser Tyr Asn Asp Ile 
            180                 185                 190         


Gln Asp Leu Met Asp Ser Gly Asn Lys Ala Arg Thr Val Ala Ala Thr 
        195                 200                 205             


Asn Met Asn Glu Thr Ser Ser Arg Ser His Ala Val Phe Asn Ile Ile 
    210                 215                 220                 


Phe Thr Gln Lys Arg His Asp Ala Glu Thr Asn Ile Thr Thr Glu Lys 
225                 230                 235                 240 


Val Ser Lys Ile Ser Leu Val Asp Leu Ala Gly Ser Glu Arg Ala Asp 
                245                 250                 255     


Ser Thr Gly Ala Lys Gly Thr Arg Leu Lys Glu Gly Ala Asn Ile Asn 
            260                 265                 270         


Lys Ser Leu Thr Thr Leu Gly Lys Val Ile Ser Ala Leu Ala Glu Met 
        275                 280                 285             


Asp Ser Gly Pro Asn Lys Asn Lys Lys Lys Lys Lys Thr Asp Phe Ile 
    290                 295                 300                 


Pro Tyr Arg Asp Ser Val Leu Thr Trp Leu Leu Arg Glu Asn Leu Gly 
305                 310                 315                 320 


Gly Asn Ser Arg Thr Ala Met Val Ala Ala Leu Ser Pro Ala Asp Ile 
                325                 330                 335     


Asn Tyr Asp Glu Thr Leu Ser Thr Leu Arg Tyr Ala Asp Arg Ala Lys 
            340                 345                 350         


Gln Ile Arg Cys Asn Ala Val Ile Asn Glu Asp Pro Asn Asn Lys Leu 
        355                 360                 365             


Ile Arg Glu Leu Lys Asp Glu Val Thr Arg Leu Arg Asp Leu Leu Tyr 
    370                 375                 380                 


Ala Gln Gly Leu Gly Asp Ile Thr Asp Met Thr Asn Ala Leu Val Gly 
385                 390                 395                 400 


Met Ser Pro Ser Ser Ser Leu Ser Ala Leu Ser Ser Arg Ala Ala Ser 
                405                 410                 415     


Val Ser Ser Leu His Glu Arg Ile Leu Phe Ala Pro Gly Ser Glu Glu 
            420                 425                 430         


Ala Ile Glu Arg Leu Lys Glu Thr Glu Lys Ile Ile Ala Glu Leu Asn 
        435                 440                 445             


Glu Thr Trp Glu Glu Lys Leu Arg Arg Thr Glu Ala Ile Arg Met Glu 
    450                 455                 460                 


Arg Glu Ala Leu Leu Ala Glu Met Gly Val Ala Met Arg Glu Asp Gly 
465                 470                 475                 480 


Gly Thr Leu Gly Val Phe Ser Pro Lys Lys Thr Pro His Leu Val Asn 
                485                 490                 495     


Leu Asn Glu Asp Pro Leu Met Ser Glu Cys Leu Leu Tyr Tyr Ile Lys 
            500                 505                 510         


Asp Gly Ile Thr Arg Val Gly Arg Glu Asp Gly Glu Arg Arg Gln Asp 
        515                 520                 525             


Ile Val Leu Ser Gly His Phe Ile Lys Glu Glu His Cys Val Phe Arg 
    530                 535                 540                 


Ser Asp Ser Arg Gly Gly Ser Glu Ala Val Val Thr Leu Glu Pro Cys 
545                 550                 555                 560 


Glu Gly Ala Asp Thr Tyr Val Asn Gly Lys Lys Val Thr Glu Pro Ser 
                565                 570                 575     


Ile Leu Arg Ser Gly Asn Arg Ile Ile Met Gly Lys Ser His Val Phe 
            580                 585                 590         


Arg Phe Asn His Pro Glu Gln Ala Arg Gln Glu Arg Glu Arg Thr Pro 
        595                 600                 605             


Cys Ala Glu Thr Pro Ala Glu Pro Val Asp Trp Ala Phe Ala Gln Arg 
    610                 615                 620                 


Glu Leu Leu Glu Lys Gln Gly Ile Asp Met Lys Gln Glu Met Glu Gln 
625                 630                 635                 640 


Arg Leu Gln Glu Leu Glu Asp Gln Tyr Arg Arg Glu Arg Glu Glu Ala 
                645                 650                 655     


Thr Tyr Leu Leu Glu Gln Gln Arg Leu Asp Tyr Glu Ser Lys Leu Glu 
            660                 665                 670         


Ala Leu Gln Lys Gln Met Asp Ser Arg Tyr Tyr Pro Glu Val Asn Glu 
        675                 680                 685             


Glu Glu Glu Glu Pro Glu Asp Glu Val Gln Trp Thr Glu Arg Glu Cys 
    690                 695                 700                 


Glu Leu Ala Leu Trp Ala Phe Arg Lys Trp Lys Trp Tyr Gln Phe Thr 
705                 710                 715                 720 


Ser Leu Arg Asp Leu Leu Trp Gly Asn Ala Ile Phe Leu Lys Glu Ala 
                725                 730                 735     


Asn Ala Ile Ser Val Glu Leu Lys Lys Lys Val Gln Phe Gln Phe Val 
            740                 745                 750         


Leu Leu Thr Asp Thr Leu Tyr Ser Pro Leu Pro Pro Asp Leu Leu Pro 
        755                 760                 765             


Pro Glu Ala Ala Lys Asp Arg Glu Thr Arg Pro Phe Pro Arg Thr Ile 
    770                 775                 780                 


Val Ala Val Glu Val Gln Asp Gln Lys Asn Gly Ala Thr His Tyr Trp 
785                 790                 795                 800 


Thr Leu Glu Lys Leu Arg Gln Arg Leu Asp Leu Met Arg Glu Met Tyr 
                805                 810                 815     


Asp Arg Ala Ala Glu Val Pro Ser Ser Val Ile Glu Asp Cys Asp Asn 
            820                 825                 830         


Val Val Thr Gly Gly Asp Pro Phe Tyr Asp Arg Phe Pro Trp Phe Arg 
        835                 840                 845             


Leu Val Gly Arg Ala Phe Val Tyr Leu Ser Asn Leu Leu Tyr Pro Val 
    850                 855                 860                 


Pro Leu Val His Arg Val Ala Ile Val Ser Glu Lys Gly Glu Val Lys 
865                 870                 875                 880 


Gly Phe Leu Arg Val Ala Val Gln Ala Ile Ser Ala Asp Glu Glu Ala 
                885                 890                 895     


Pro Asp Tyr Gly Ser Gly Val Arg Gln Ser Gly Thr Ala Lys Ile Ser 
            900                 905                 910         


Phe Asp Asp Gln His Phe Glu Lys Phe Gln Ser Glu Ser Cys Pro Val 
        915                 920                 925             


Val Gly Met Ser Arg Ser Gly Thr Ser Gln Glu Glu Leu Arg Ile Val 
    930                 935                 940                 


Glu Gly Gln Gly Gln Gly Ala Asp Val Gly Pro Ser Ala Asp Glu Val 
945                 950                 955                 960 


Asn Asn Asn Thr Cys Ser Ala Val Pro Pro Glu Gly Leu Leu Leu Asp 
                965                 970                 975     


Ser Ser Glu Lys Ala Ala Leu Asp Gly Pro Leu Asp Ala Ala Leu Asp 
            980                 985                 990         


His Leu Arg Leu Gly Asn Thr Phe  Thr Phe Arg Val Thr  Val Leu Gln 
        995                 1000                 1005             


Ala Ser  Ser Ile Ser Ala Glu  Tyr Ala Asp Ile Phe  Cys Gln Phe 
    1010                 1015                 1020             


Asn Phe  Ile His Arg His Asp  Glu Ala Phe Ser Thr  Glu Pro Leu 
    1025                 1030                 1035             


Lys Asn  Thr Gly Arg Gly Pro  Pro Leu Gly Phe Tyr  His Val Gln 
    1040                 1045                 1050             


Asn Ile  Ala Val Glu Val Thr  Lys Ser Phe Ile Glu  Tyr Ile Lys 
    1055                 1060                 1065             


Ser Gln  Pro Ile Val Phe Glu  Val Phe Gly His Tyr  Gln Gln His 
    1070                 1075                 1080             


Pro Phe  Pro Pro Leu Cys Lys  Asp Val Leu Ser Pro  Leu Arg Pro 
    1085                 1090                 1095             


Ser Arg  Arg His Phe Pro Arg  Val Met Pro Leu Ser  Lys Pro Val 
    1100                 1105                 1110             


Pro Ala  Thr Lys Leu Ser Thr  Leu Thr Arg Pro Cys  Pro Gly Pro 
    1115                 1120                 1125             


Cys His  Cys Lys Tyr Asp Leu  Leu Val Tyr Phe Glu  Ile Cys Glu 
    1130                 1135                 1140             


Leu Glu  Ala Asn Gly Asp Tyr  Ile Pro Ala Val Val  Asp His Arg 
    1145                 1150                 1155             


Gly Gly  Met Pro Cys Met Gly  Thr Phe Leu Leu His  Gln Gly Ile 
    1160                 1165                 1170             


Gln Arg  Arg Ile Thr Val Thr  Leu Leu His Glu Thr  Gly Ser His 
    1175                 1180                 1185             


Ile Arg  Trp Lys Glu Val Arg  Glu Leu Val Val Gly  Arg Ile Arg 
    1190                 1195                 1200             


Asn Thr  Pro Glu Thr Asp Glu  Ser Leu Ile Asp Pro  Asn Ile Leu 
    1205                 1210                 1215             


Ser Leu  Asn Ile Leu Ser Ser  Gly Tyr Ile His Pro  Ala Gln Asp 
    1220                 1225                 1230             


Asp Arg  Thr Phe Tyr Gln Phe  Glu Ala Ala Trp Asp  Ser Ser Met 
    1235                 1240                 1245             


His Asn  Ser Leu Leu Leu Asn  Arg Val Thr Pro Tyr  Arg Glu Lys 
    1250                 1255                 1260             


Ile Tyr  Met Thr Leu Ser Ala  Tyr Ile Glu Met Glu  Asn Cys Thr 
    1265                 1270                 1275             


Gln Pro  Ala Val Val Thr Lys  Asp Phe Cys Met Val  Phe Tyr Ser 
    1280                 1285                 1290             


Arg Asp  Ala Lys Leu Pro Ala  Ser Arg Ser Ile Arg  Asn Leu Phe 
    1295                 1300                 1305             


Gly Ser  Gly Ser Leu Arg Ala  Ser Glu Ser Asn Arg  Val Thr Gly 
    1310                 1315                 1320             


Val Tyr  Glu Leu Ser Leu Cys  His Val Ala Asp Ala  Gly Ser Pro 
    1325                 1330                 1335             


Gly Met  Gln Arg Arg Arg Arg  Arg Val Leu Asp Thr  Ser Val Ala 
    1340                 1345                 1350             


Tyr Val  Arg Gly Glu Glu Asn  Leu Ala Gly Trp Arg  Pro Arg Ser 
    1355                 1360                 1365             


Asp Ser  Leu Ile Leu Asp His  Gln Trp Glu Leu Glu  Lys Leu Ser 
    1370                 1375                 1380             


Leu Leu  Gln Glu Val Glu Lys  Thr Arg His Tyr Leu  Leu Leu Arg 
    1385                 1390                 1395             


Glu Lys  Leu Glu Thr Ala Gln  Arg Pro Val Pro Glu  Ala Leu Ser 
    1400                 1405                 1410             


Pro Ala  Phe Ser Glu Asp Ser  Glu Ser His Gly Ser  Ser Ser Ala 
    1415                 1420                 1425             


Ser Ser  Pro Leu Ser Ala Glu  Gly Arg Pro Ser Pro  Leu Glu Ala 
    1430                 1435                 1440             


Pro Asn  Glu Arg Gln Arg Glu  Leu Ala Val Lys Cys  Leu Arg Leu 
    1445                 1450                 1455             


Leu Thr  His Thr Phe Asn Arg  Glu Tyr Thr His Ser  His Val Cys 
    1460                 1465                 1470             


Val Ser  Ala Ser Glu Ser Lys  Leu Ser Glu Met Ser  Val Thr Leu 
    1475                 1480                 1485             


Leu Arg  Asp Pro Ser Met Ser  Pro Leu Gly Val Ala  Thr Leu Thr 
    1490                 1495                 1500             


Pro Ser  Ser Thr Cys Pro Ser  Leu Val Glu Gly Arg  Tyr Gly Ala 
    1505                 1510                 1515             


Thr Asp  Leu Arg Thr Pro Gln  Pro Cys Ser Arg Pro  Ala Ser Pro 
    1520                 1525                 1530             


Glu Pro  Glu Leu Leu Pro Glu  Ala Asp Ser Lys Lys  Leu Pro Ser 
    1535                 1540                 1545             


Pro Ala  Arg Ala Thr Glu Thr  Asp Lys Glu Pro Gln  Arg Leu Leu 
    1550                 1555                 1560             


Val Pro  Asp Ile Gln Glu Ile  Arg Val Ser Pro Ile  Val Ser Lys 
    1565                 1570                 1575             


Lys Gly  Tyr Leu His Phe Leu  Glu Pro His Thr Ser  Gly Trp Ala 
    1580                 1585                 1590             


Arg Arg  Phe Val Val Val Arg  Arg Pro Tyr Ala Tyr  Met Tyr Asn 
    1595                 1600                 1605             


Ser Asp  Lys Asp Thr Val Glu  Arg Phe Val Leu Asn  Leu Ala Thr 
    1610                 1615                 1620             


Ala Gln  Val Glu Tyr Ser Glu  Asp Gln Gln Ala Met  Leu Lys Thr 
    1625                 1630                 1635             


Pro Asn  Thr Phe Ala Val Cys  Thr Glu His Arg Gly  Ile Leu Leu 
    1640                 1645                 1650             


Gln Ala  Ala Ser Asp Lys Asp  Met His Asp Trp Leu  Tyr Ala Phe 
    1655                 1660                 1665             


Asn Pro  Leu Leu Ala Gly Thr  Ile Arg Ser Lys Leu  Ser Arg Arg 
    1670                 1675                 1680             


Arg Ser  Ala Gln Met Arg Val  Lys Val Pro Val Phe  Thr Leu Glu 
    1685                 1690                 1695             


Asp Phe  Val Gly Asp Trp Arg  Gln Thr Ala Gly Tyr  Asn Leu Asp 
    1700                 1705                 1710             


Gln Val  Leu Glu Gln Gly Gly  Val Ser Ser Leu Phe  Gln Asn Leu 
    1715                 1720                 1725             


Gly Val  Ser Val Thr Pro Ile  Gln Arg Ile Val Leu  Ser Gly Glu 
    1730                 1735                 1740             


Asn Gly  Leu Lys Ile Asp Ile  His Val Ile Ile Pro  Tyr Glu Gly 
    1745                 1750                 1755             


Leu Ser  Gly Asp Gln Met Gly  Gln Ile Glu Lys Ile  Phe Lys Val 
    1760                 1765                 1770             


Val Tyr  Pro Val Asp Asp His  His Phe Lys Val Ile  Leu His Tyr 
    1775                 1780                 1785             


Gly Thr  Leu Val Ile Asp Gly  Val Thr Pro Asn Met  Ile Asp Tyr 
    1790                 1795                 1800             


Phe Gly  Arg Pro Tyr Glu Gly  Ile Ala Val Phe Asp  Gly Lys Lys 
    1805                 1810                 1815             


Ile Thr  Val Thr Gly Thr Leu  Trp Asn Gly Asn Lys  Ile Ile Asp 
    1820                 1825                 1830             


Glu Arg  Leu Ile Asn Pro Asp  Gly Ser Leu Leu Phe  Arg Val Thr 
    1835                 1840                 1845             


Ile Asn  Gly Val Thr Gly Trp  Arg Leu Cys Glu Arg  Ile Leu Ala 
    1850                 1855                 1860             


Gly Gly  Gly Gly Ser Pro Ser  Arg Leu Glu Glu Glu  Leu Arg Arg 
    1865                 1870                 1875             


Arg Leu  Thr Glu Pro 
    1880             


<210> 395
<211> 1536
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 395
Met Ser Arg Ser Arg Ala Ser Ile His Arg Gly Ser Ile Pro Ala Met 
1               5                   10                  15      


Ser Tyr Ala Pro Phe Arg Asp Val Arg Gly Pro Ser Met His Arg Thr 
            20                  25                  30          


Gln Tyr Val His Ser Pro Tyr Asp Arg Pro Gly Trp Asn Pro Arg Phe 
        35                  40                  45              


Cys Ile Ile Ser Gly Asn Gln Leu Leu Met Leu Asp Glu Asp Glu Ile 
    50                  55                  60                  


His Pro Leu Leu Ile Arg Asp Arg Arg Ser Glu Ser Ser Arg Asn Lys 
65                  70                  75                  80  


Leu Leu Arg Arg Thr Val Ser Val Pro Val Glu Gly Arg Pro His Gly 
                85                  90                  95      


Glu His Glu Tyr His Leu Gly Arg Ser Arg Arg Lys Ser Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Tyr Ser Met Glu Gly Ala Pro Ala Ala Pro Phe Arg Pro 
        115                 120                 125             


Ser Gln Gly Phe Leu Ser Arg Arg Leu Lys Ser Ser Ile Lys Arg Thr 
    130                 135                 140                 


Lys Ser Gln Pro Lys Leu Asp Arg Thr Ser Ser Phe Arg Gln Ile Leu 
145                 150                 155                 160 


Pro Arg Phe Arg Ser Ala Asp His Asp Arg Ala Arg Leu Met Gln Ser 
                165                 170                 175     


Phe Lys Glu Ser His Ser His Glu Ser Leu Leu Ser Pro Ser Ser Ala 
            180                 185                 190         


Ala Glu Ala Leu Glu Leu Asn Leu Asp Glu Asp Ser Ile Ile Lys Pro 
        195                 200                 205             


Val His Ser Ser Ile Leu Gly Gln Glu Phe Cys Phe Glu Val Thr Thr 
    210                 215                 220                 


Ser Ser Gly Thr Lys Cys Phe Ala Cys Arg Ser Ala Ala Glu Arg Asp 
225                 230                 235                 240 


Lys Trp Ile Glu Asn Leu Gln Arg Ala Val Lys Pro Asn Lys Asp Asn 
                245                 250                 255     


Ser Arg Arg Val Asp Asn Val Leu Lys Leu Trp Ile Ile Glu Ala Arg 
            260                 265                 270         


Glu Leu Pro Pro Lys Lys Arg Tyr Tyr Cys Glu Leu Cys Leu Asp Asp 
        275                 280                 285             


Met Leu Tyr Ala Arg Thr Thr Ser Lys Pro Arg Ser Ala Ser Gly Asp 
    290                 295                 300                 


Thr Val Phe Trp Gly Glu His Phe Glu Phe Asn Asn Leu Pro Ala Val 
305                 310                 315                 320 


Arg Ala Leu Arg Leu His Leu Tyr Arg Asp Ser Asp Lys Lys Arg Lys 
                325                 330                 335     


Lys Asp Lys Ala Gly Tyr Val Gly Leu Val Thr Val Pro Val Ala Thr 
            340                 345                 350         


Leu Ala Gly Arg His Phe Thr Glu Gln Trp Tyr Pro Val Thr Leu Pro 
        355                 360                 365             


Thr Gly Ser Gly Gly Ser Gly Gly Met Gly Ser Gly Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Ser Gly Gly Lys Gly Lys Gly Gly Cys Pro Ala Val 
385                 390                 395                 400 


Arg Leu Lys Ala Arg Tyr Gln Thr Met Ser Ile Leu Pro Met Glu Leu 
                405                 410                 415     


Tyr Lys Glu Phe Ala Glu Tyr Val Thr Asn His Tyr Arg Met Leu Cys 
            420                 425                 430         


Ala Val Leu Glu Pro Ala Leu Asn Val Lys Gly Lys Glu Glu Val Ala 
        435                 440                 445             


Ser Ala Leu Val His Ile Leu Gln Ser Thr Gly Lys Ala Lys Asp Phe 
    450                 455                 460                 


Leu Ser Asp Met Ala Met Ser Glu Val Asp Arg Phe Met Glu Arg Glu 
465                 470                 475                 480 


His Leu Ile Phe Arg Glu Asn Thr Leu Ala Thr Lys Ala Ile Glu Glu 
                485                 490                 495     


Tyr Met Arg Leu Ile Gly Gln Lys Tyr Leu Lys Asp Ala Ile Gly Glu 
            500                 505                 510         


Phe Ile Arg Ala Leu Tyr Glu Ser Glu Glu Asn Cys Glu Val Asp Pro 
        515                 520                 525             


Ile Lys Cys Thr Ala Ser Ser Leu Ala Glu His Gln Ala Asn Leu Arg 
    530                 535                 540                 


Met Cys Cys Glu Leu Ala Leu Cys Lys Val Val Asn Ser His Cys Val 
545                 550                 555                 560 


Phe Pro Arg Glu Leu Lys Glu Val Phe Ala Ser Trp Arg Leu Arg Cys 
                565                 570                 575     


Ala Glu Arg Gly Arg Glu Asp Ile Ala Asp Arg Leu Ile Ser Ala Ser 
            580                 585                 590         


Leu Phe Leu Arg Phe Leu Cys Pro Ala Ile Met Ser Pro Ser Leu Phe 
        595                 600                 605             


Gly Leu Met Gln Glu Tyr Pro Asp Glu Gln Thr Ser Arg Thr Leu Thr 
    610                 615                 620                 


Leu Ile Ala Lys Val Ile Gln Asn Leu Ala Asn Phe Ser Lys Phe Thr 
625                 630                 635                 640 


Ser Lys Glu Asp Phe Leu Gly Phe Met Asn Glu Phe Leu Glu Leu Glu 
                645                 650                 655     


Trp Gly Ser Met Gln Gln Phe Leu Tyr Glu Ile Ser Asn Leu Asp Thr 
            660                 665                 670         


Leu Thr Asn Ser Ser Ser Phe Glu Gly Tyr Ile Asp Leu Gly Arg Glu 
        675                 680                 685             


Leu Ser Thr Leu His Ala Leu Leu Trp Glu Val Leu Pro Gln Leu Ser 
    690                 695                 700                 


Lys Glu Ala Leu Leu Lys Leu Gly Pro Leu Pro Arg Leu Leu Asn Asp 
705                 710                 715                 720 


Ile Ser Thr Ala Leu Arg Asn Pro Asn Ile Gln Arg Gln Pro Ser Arg 
                725                 730                 735     


Gln Ser Glu Arg Pro Arg Pro Gln Pro Val Val Leu Arg Gly Pro Ser 
            740                 745                 750         


Ala Glu Met Gln Gly Tyr Met Met Arg Asp Leu Asn Ser Ser Ile Asp 
        755                 760                 765             


Leu Gln Ser Phe Met Ala Arg Gly Leu Asn Ser Ser Met Asp Met Ala 
    770                 775                 780                 


Arg Leu Pro Ser Pro Thr Lys Glu Lys Pro Pro Pro Pro Pro Pro Gly 
785                 790                 795                 800 


Gly Gly Lys Asp Leu Phe Tyr Val Ser Arg Pro Pro Leu Ala Arg Ser 
                805                 810                 815     


Ser Pro Ala Tyr Cys Thr Ser Ser Ser Asp Ile Thr Glu Pro Glu Gln 
            820                 825                 830         


Lys Met Leu Ser Val Asn Lys Ser Val Ser Met Leu Asp Leu Gln Gly 
        835                 840                 845             


Asp Gly Pro Gly Gly Arg Leu Asn Ser Ser Ser Val Ser Asn Leu Ala 
    850                 855                 860                 


Ala Val Gly Asp Leu Leu His Ser Ser Gln Ala Ser Leu Thr Ala Ala 
865                 870                 875                 880 


Leu Gly Leu Arg Pro Ala Pro Ala Gly Arg Leu Ser Gln Gly Ser Gly 
                885                 890                 895     


Ser Ser Ile Thr Ala Ala Gly Met Arg Leu Ser Gln Met Gly Val Thr 
            900                 905                 910         


Thr Asp Gly Val Pro Ala Gln Gln Leu Arg Ile Pro Leu Ser Phe Gln 
        915                 920                 925             


Asn Pro Leu Phe His Met Ala Ala Asp Gly Pro Gly Pro Pro Gly Gly 
    930                 935                 940                 


His Gly Gly Gly Gly Gly His Gly Pro Pro Ser Ser His His His His 
945                 950                 955                 960 


His His His His His His Arg Gly Gly Glu Pro Pro Gly Asp Thr Phe 
                965                 970                 975     


Ala Pro Phe His Gly Tyr Ser Lys Ser Glu Asp Leu Ser Ser Gly Val 
            980                 985                 990         


Pro Lys Pro Pro Ala Ala Ser Ile  Leu His Ser His Ser  Tyr Ser Asp 
        995                 1000                 1005             


Glu Phe  Gly Pro Ser Gly Thr  Asp Phe Thr Arg Arg  Gln Leu Ser 
    1010                 1015                 1020             


Leu Gln  Asp Asn Leu Gln His  Met Leu Ser Pro Pro  Gln Ile Thr 
    1025                 1030                 1035             


Ile Gly  Pro Gln Arg Pro Ala  Pro Ser Gly Pro Gly  Gly Gly Ser 
    1040                 1045                 1050             


Gly Gly  Gly Ser Gly Gly Gly  Gly Gly Gly Gln Pro  Pro Pro Leu 
    1055                 1060                 1065             


Gln Arg  Gly Lys Ser Gln Gln  Leu Thr Val Ser Ala  Ala Gln Lys 
    1070                 1075                 1080             


Pro Arg  Pro Ser Ser Gly Asn  Leu Leu Gln Ser Pro  Glu Pro Ser 
    1085                 1090                 1095             


Tyr Gly  Pro Ala Arg Pro Arg  Gln Gln Ser Leu Ser  Lys Glu Gly 
    1100                 1105                 1110             


Ser Ile  Gly Gly Ser Gly Gly  Ser Gly Gly Gly Gly  Gly Gly Gly 
    1115                 1120                 1125             


Leu Lys  Pro Ser Ile Thr Lys  Gln His Ser Gln Thr  Pro Ser Thr 
    1130                 1135                 1140             


Leu Asn  Pro Thr Met Pro Ala  Ser Glu Arg Thr Val  Ala Trp Val 
    1145                 1150                 1155             


Ser Asn  Met Pro His Leu Ser  Ala Asp Ile Glu Ser  Ala His Ile 
    1160                 1165                 1170             


Glu Arg  Glu Glu Tyr Lys Leu  Lys Glu Tyr Ser Lys  Ser Met Asp 
    1175                 1180                 1185             


Glu Ser  Arg Leu Asp Arg Val  Lys Glu Tyr Glu Glu  Glu Ile His 
    1190                 1195                 1200             


Ser Leu  Lys Glu Arg Leu His  Met Ser Asn Arg Lys  Leu Glu Glu 
    1205                 1210                 1215             


Tyr Glu  Arg Arg Leu Leu Ser  Gln Glu Glu Gln Thr  Ser Lys Ile 
    1220                 1225                 1230             


Leu Met  Gln Tyr Gln Ala Arg  Leu Glu Gln Ser Glu  Lys Arg Leu 
    1235                 1240                 1245             


Arg Gln  Gln Gln Ala Glu Lys  Asp Ser Gln Ile Lys  Ser Ile Ile 
    1250                 1255                 1260             


Gly Arg  Leu Met Leu Val Glu  Glu Glu Leu Arg Arg  Asp His Pro 
    1265                 1270                 1275             


Ala Met  Ala Glu Pro Leu Pro  Glu Pro Lys Lys Arg  Leu Leu Asp 
    1280                 1285                 1290             


Ala Gln  Glu Arg Gln Leu Pro  Pro Leu Gly Pro Thr  Asn Pro Arg 
    1295                 1300                 1305             


Val Thr  Leu Ala Pro Pro Trp  Asn Gly Leu Ala Pro  Pro Ala Pro 
    1310                 1315                 1320             


Pro Pro  Pro Pro Arg Leu Gln  Ile Thr Glu Asn Gly  Glu Phe Arg 
    1325                 1330                 1335             


Asn Thr  Ala Asp His Lys Val  Pro Val Phe Thr Leu  Glu Asp Phe 
    1340                 1345                 1350             


Val Gly  Asp Trp Arg Gln Thr  Ala Gly Tyr Asn Leu  Asp Gln Val 
    1355                 1360                 1365             


Leu Glu  Gln Gly Gly Val Ser  Ser Leu Phe Gln Asn  Leu Gly Val 
    1370                 1375                 1380             


Ser Val  Thr Pro Ile Gln Arg  Ile Val Leu Ser Gly  Glu Asn Gly 
    1385                 1390                 1395             


Leu Lys  Ile Asp Ile His Val  Ile Ile Pro Tyr Glu  Gly Leu Ser 
    1400                 1405                 1410             


Gly Asp  Gln Met Gly Gln Ile  Glu Lys Ile Phe Lys  Val Val Tyr 
    1415                 1420                 1425             


Pro Val  Asp Asp His His Phe  Lys Val Ile Leu His  Tyr Gly Thr 
    1430                 1435                 1440             


Leu Val  Ile Asp Gly Val Thr  Pro Asn Met Ile Asp  Tyr Phe Gly 
    1445                 1450                 1455             


Arg Pro  Tyr Glu Gly Ile Ala  Val Phe Asp Gly Lys  Lys Ile Thr 
    1460                 1465                 1470             


Val Thr  Gly Thr Leu Trp Asn  Gly Asn Lys Ile Ile  Asp Glu Arg 
    1475                 1480                 1485             


Leu Ile  Asn Pro Asp Gly Ser  Leu Leu Phe Arg Val  Thr Ile Asn 
    1490                 1495                 1500             


Gly Val  Thr Gly Trp Arg Leu  Cys Glu Arg Ile Leu  Ala Gly Gly 
    1505                 1510                 1515             


Gly Gly  Ser Pro Ser Arg Leu  Glu Glu Glu Leu Arg  Arg Arg Leu 
    1520                 1525                 1530             


Thr Glu  Pro 
    1535     


<210> 396
<211> 290
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 396
Met Ala Ser Ser Ala Glu Leu Asp Phe Asn Leu Gln Ala Leu Leu Glu 
1               5                   10                  15      


Gln Leu Ser Gln Asp Glu Leu Ser Lys Phe Lys Ser Leu Ile Arg Thr 
            20                  25                  30          


Ile Ser Leu Gly Lys Glu Leu Gln Thr Val Pro Gln Thr Glu Val Asp 
        35                  40                  45              


Lys Ala Asn Gly Lys Gln Leu Val Glu Ile Phe Thr Ser His Ser Cys 
    50                  55                  60                  


Ser Tyr Trp Ala Gly Met Ala Ala Ile Gln Val Phe Glu Lys Met Asn 
65                  70                  75                  80  


Gln Thr His Leu Ser Gly Arg Ala Asp Glu His Cys Val Met Pro Pro 
                85                  90                  95      


Pro Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg 
            100                 105                 110         


Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val 
        115                 120                 125             


Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg 
    130                 135                 140                 


Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile 
145                 150                 155                 160 


Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys 
                165                 170                 175     


Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile 
            180                 185                 190         


Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile 
        195                 200                 205             


Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys 
    210                 215                 220                 


Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp 
225                 230                 235                 240 


Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile 
                245                 250                 255     


Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly 
            260                 265                 270         


Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr 
        275                 280                 285             


Glu Pro 
    290 


<210> 397
<211> 291
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 397
Met Met Cys Gly Ala Pro Ser Ala Thr Gln Pro Ala Thr Ala Glu Thr 
1               5                   10                  15      


Gln His Ile Ala Asp Gln Val Arg Ser Gln Leu Glu Glu Lys Glu Asn 
            20                  25                  30          


Lys Lys Phe Pro Val Phe Lys Ala Val Ser Phe Lys Ser Gln Val Val 
        35                  40                  45              


Ala Gly Thr Asn Tyr Phe Ile Lys Val His Val Gly Asp Glu Asp Phe 
    50                  55                  60                  


Val His Leu Arg Val Phe Gln Ser Leu Pro His Glu Asn Lys Pro Leu 
65                  70                  75                  80  


Thr Leu Ser Asn Tyr Gln Thr Asn Lys Ala Lys His Asp Glu Leu Thr 
                85                  90                  95      


Tyr Phe Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp 
            100                 105                 110         


Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly 
        115                 120                 125             


Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln 
    130                 135                 140                 


Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val 
145                 150                 155                 160 


Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu 
                165                 170                 175     


Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val 
            180                 185                 190         


Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met 
        195                 200                 205             


Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly 
    210                 215                 220                 


Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile 
225                 230                 235                 240 


Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr 
                245                 250                 255     


Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly 
            260                 265                 270         


Gly Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu 
        275                 280                 285             


Thr Glu Pro 
    290     


<210> 398
<211> 297
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 398
Met Ala Gly Lys Ala His Arg Leu Ser Ala Glu Glu Arg Asp Gln Leu 
1               5                   10                  15      


Leu Pro Asn Leu Arg Ala Val Gly Trp Asn Glu Leu Glu Gly Arg Asp 
            20                  25                  30          


Ala Ile Phe Lys Gln Phe His Phe Lys Asp Phe Asn Arg Ala Phe Gly 
        35                  40                  45              


Phe Met Thr Arg Val Ala Leu Gln Ala Glu Lys Leu Asp His His Pro 
    50                  55                  60                  


Glu Trp Phe Asn Val Tyr Asn Lys Val His Ile Thr Leu Ser Thr His 
65                  70                  75                  80  


Glu Cys Ala Gly Leu Ser Glu Arg Asp Ile Asn Leu Ala Ser Phe Ile 
                85                  90                  95      


Glu Gln Val Ala Val Ser Met Thr Lys Val Pro Val Phe Thr Leu Glu 
            100                 105                 110         


Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln 
        115                 120                 125             


Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly Val 
    130                 135                 140                 


Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly Leu 
145                 150                 155                 160 


Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp 
                165                 170                 175     


Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro Val Asp 
            180                 185                 190         


Asp His His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val Ile Asp 
        195                 200                 205             


Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly 
    210                 215                 220                 


Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp 
225                 230                 235                 240 


Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser 
                245                 250                 255     


Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg Leu Cys 
            260                 265                 270         


Glu Arg Ile Leu Ala Gly Gly Gly Gly Ser Pro Ser Arg Leu Glu Glu 
        275                 280                 285             


Glu Leu Arg Arg Arg Leu Thr Glu Pro 
    290                 295         


<210> 399
<211> 706
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 399
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Glu Val Gln Leu Gln Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
        595                 600                 605             


Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr 
    610                 615                 620                 


Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser Glu 
625                 630                 635                 640 


Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val 
                645                 650                 655     


Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu 
            660                 665                 670         


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg 
        675                 680                 685             


Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    690                 695                 700                 


Ser Ser 
705     


<210> 400
<211> 976
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 400
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
            580                 585                 590         


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
        595                 600                 605             


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
    610                 615                 620                 


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
625                 630                 635                 640 


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
                645                 650                 655     


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
            660                 665                 670         


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
        675                 680                 685             


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
    690                 695                 700                 


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
705                 710                 715                 720 


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
                725                 730                 735     


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
            740                 745                 750         


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
        755                 760                 765             


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
    770                 775                 780                 


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
785                 790                 795                 800 


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
                805                 810                 815     


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
            820                 825                 830         


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
        835                 840                 845             


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
    850                 855                 860                 


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
865                 870                 875                 880 


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
                885                 890                 895     


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
            900                 905                 910         


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
        915                 920                 925             


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
    930                 935                 940                 


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
945                 950                 955                 960 


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                965                 970                 975     


<210> 401
<211> 1106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 401
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Glu Val Gln Leu Gln Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
        595                 600                 605             


Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr 
    610                 615                 620                 


Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser Glu 
625                 630                 635                 640 


Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val 
                645                 650                 655     


Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu 
            660                 665                 670         


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg 
        675                 680                 685             


Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    690                 695                 700                 


Ser Ser Gly Ala Pro Gly Ser Gly Pro Pro Ser Phe Ser Glu Gly Ser 
705                 710                 715                 720 


Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr 
                725                 730                 735     


Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu 
            740                 745                 750         


Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser 
        755                 760                 765             


Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn 
    770                 775                 780                 


Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu 
785                 790                 795                 800 


Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
                805                 810                 815     


Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
            820                 825                 830         


Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr 
        835                 840                 845             


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
    850                 855                 860                 


Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu 
865                 870                 875                 880 


Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp 
                885                 890                 895     


Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp 
            900                 905                 910         


Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu 
        915                 920                 925             


Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu 
    930                 935                 940                 


Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe 
945                 950                 955                 960 


Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr 
                965                 970                 975     


Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly 
            980                 985                 990         


Gly Ile Tyr Leu Pro Leu Glu Val  Pro Ala Ser Gln Cys  His Arg Ser 
        995                 1000                 1005             


Pro Leu  Val Leu Ala Tyr Asp  Gln Ala His Phe Ser  Ala Leu Val 
    1010                 1015                 1020             


Ser Met  Glu Gln Lys Glu Asn  Thr Lys Glu Gln Ala  Val Ile Pro 
    1025                 1030                 1035             


Leu Thr  Asp Ser Glu Tyr Lys  Leu Leu Pro Leu His  Phe Ala Val 
    1040                 1045                 1050             


Asp Pro  Gly Lys Gly Trp Glu  Trp Gly Lys Asp Asp  Ser Asp Asn 
    1055                 1060                 1065             


Val Arg  Leu Ala Ser Val Ile  Leu Ser Leu Glu Val  Lys Leu His 
    1070                 1075                 1080             


Leu Leu  His Ser Tyr Met Asn  Val Lys Trp Ile Pro  Leu Ser Ser 
    1085                 1090                 1095             


Asp Ala  Gln Ala Pro Leu Ala  Gln 
    1100                 1105     


<210> 402
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 402
Ala His Phe Lys Ile Ser Gly Glu Lys Arg Pro Ser Thr Asp Pro Gly 
1               5                   10                  15      


Lys Lys Ala Lys Asn Pro Lys Lys Lys Lys Lys Lys Asp Pro 
            20                  25                  30  


<210> 403
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 403
Ala His Arg Ala Lys Lys Met Ser Lys Thr His Ala 
1               5                   10          


<210> 404
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 404
Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
1               5                   10                  


<210> 405
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 405
Cys Thr Lys Arg Pro Arg Trp 
1               5           


<210> 406
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 406
Asp Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg 
1               5                   10                  15      


<210> 407
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 407
Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile Tyr Ala 
1               5                   10                  15  


<210> 408
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 408
Glu Glu Gln Leu Arg Arg Arg Lys Asn Ser Arg Leu Asn Asn Thr Gly 
1               5                   10                  15      


<210> 409
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 409
Glu Val Leu Lys Val Ile Arg Thr Gly Lys Arg Lys Lys Lys Ala Trp 
1               5                   10                  15      


Lys Arg Met Val Thr Lys Val Cys 
            20                  


<210> 410
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 410
His His His His His His His His His His His His Gln Pro His 
1               5                   10                  15  


<210> 411
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 411
His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210> 412
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 412
His Lys Arg Thr Lys Lys Asn Leu Ser 
1               5                   


<210> 413
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 413
Ile Ile Asn Gly Arg Lys Leu Lys Leu Lys Lys Ser Arg Arg Arg Ser 
1               5                   10                  15      


Ser Gln Thr Ser Asn Asn Ser Phe Thr Ser Arg Arg Ser 
            20                  25                  


<210> 414
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 414
Lys Ala Glu Gln Glu Arg Arg Lys 
1               5               


<210> 415
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 415
Lys Glu Lys Arg Lys Arg Arg Glu Glu Leu Phe Ile Glu Gln Lys Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 416
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 416
Lys Lys Gly Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro 
1               5                   10                  


<210> 417
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 417
Lys Lys Gly Pro Ser Val Gln Lys Arg Lys Lys Thr Asn Leu Ser 
1               5                   10                  15  


<210> 418
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 418
Lys Lys Lys Thr Val Ile Asn Asp Leu Leu His Tyr Lys Lys Glu Lys 
1               5                   10                  15      


<210> 419
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 419
Lys Lys Asn Gly Gly Lys Gly Lys Asn Lys Pro Ser Ala Lys Ile Lys 
1               5                   10                  15      


Lys 
    


<210> 420
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 420
Lys Lys Pro Lys Trp Asp Asp Phe Lys Lys Lys Lys Lys 
1               5                   10              


<210> 421
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 421
Lys Lys Arg Lys Lys Asp Asn Leu Ser 
1               5                   


<210> 422
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 422
Lys Lys Arg Arg Lys Arg Arg Arg Lys 
1               5                   


<210> 423
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 423
Lys Lys Arg Arg Arg Arg Ala Arg Lys 
1               5                   


<210> 424
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 424
Lys Lys Ser Lys Arg Gly Arg 
1               5           


<210> 425
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 425
Lys Lys Ser Arg Lys Arg Gly Ser 
1               5               


<210> 426
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 426
Lys Lys Ser Thr Ala Leu Ser Arg Glu Leu Gly Lys Ile Met Arg Arg 
1               5                   10                  15      


Arg 
    


<210> 427
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 427
Lys Lys Ser Tyr Gln Asp Pro Glu Ile Ile Ala His Ser Arg Pro Arg 
1               5                   10                  15      


Lys 
    


<210> 428
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 428
Lys Lys Thr Gly Lys Asn Arg Lys Leu Lys Ser Lys Arg Val Lys Thr 
1               5                   10                  15      


Arg 
    


<210> 429
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 429
Lys Lys Val Ser Ile Ala Gly Gln Ser Gly Lys Leu Trp Arg Trp Lys 
1               5                   10                  15      


Arg 
    


<210> 430
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 430
Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210> 431
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 431
Lys Asn Lys Lys Arg Lys 
1               5       


<210> 432
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 432
Lys Pro Lys Lys Lys Arg 
1               5       


<210> 433
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 433
Lys Arg Ala Met Lys Asp Asp Ser His Gly Asn Ser Thr Ser Pro Lys 
1               5                   10                  15      


Arg Arg Lys 
            


<210> 434
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 434
Lys Arg Ala Asn Ser Asn Leu Val Ala Ala Tyr Glu Lys Ala Lys Lys 
1               5                   10                  15      


Lys 
    


<210> 435
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 435
Lys Arg Ala Ser Glu Asp Thr Thr Ser Gly Ser Pro Pro Lys Lys Ser 
1               5                   10                  15      


Ser Ala Gly Pro Lys Arg 
            20          


<210> 436
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 436
Lys Arg Phe Lys Arg Arg Trp Met Val Arg Lys Met Lys Thr Lys Lys 
1               5                   10                  15      


<210> 437
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 437
Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys 
1               5                   10                  15      


<210> 438
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 438
Lys Arg Gly Asn Ser Ser Ile Gly Pro Asn Asp Leu Ser Lys Arg Lys 
1               5                   10                  15      


Gln Arg Lys Lys 
            20  


<210> 439
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 439
Lys Arg Ile His Ser Val Ser Leu Ser Gln Ser Gln Ile Asp Pro Ser 
1               5                   10                  15      


Lys Lys Val Lys Arg Ala Lys 
            20              


<210> 440
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 440
Lys Arg Lys Gly Lys Leu Lys Asn Lys Gly Ser Lys Arg Lys Lys 
1               5                   10                  15  


<210> 441
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 441
Lys Arg Arg Arg Arg Arg Arg Arg Glu Lys Arg Lys Arg 
1               5                   10              


<210> 442
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 442
Lys Arg Ser Asn Asp Arg Thr Tyr Ser Pro Glu Glu Glu Lys Gln Arg 
1               5                   10                  15      


Arg Ala 
        


<210> 443
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 443
Lys Arg Thr Val Ala Thr Asn Gly Asp Ala Ser Gly Ala His Arg Ala 
1               5                   10                  15      


Lys Lys Met Ser Lys 
            20      


<210> 444
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 444
Lys Arg Val Tyr Asn Lys Gly Glu Asp Glu Gln Glu His Leu Pro Lys 
1               5                   10                  15      


Gly Lys Lys Arg 
            20  


<210> 445
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 445
Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn Ser 
1               5                   10                  15      


Asn Lys 
        


<210> 446
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 446
Lys Val Asn Phe Leu Asp Met Ser Leu Asp Asp Ile Ile Ile Tyr Lys 
1               5                   10                  15      


Glu Leu Glu 
            


<210> 447
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 447
Lys Val Gln His Arg Ile Ala Lys Lys Thr Thr Arg Arg Arg Arg 
1               5                   10                  15  


<210> 448
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 448
Leu Ser Pro Ser Leu Ser Pro Leu 
1               5               


<210> 449
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 449
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210> 450
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 450
Met Pro Gln Asn Glu Tyr Ile Glu Leu His Arg Lys Arg Tyr Gly Tyr 
1               5                   10                  15      


Arg Leu Asp Tyr His Glu Lys Lys Arg Lys Lys Glu Ser Arg Glu Ala 
            20                  25                  30          


His Glu Arg Ser Lys Lys Ala Lys Lys Met Ile Gly Leu Lys Ala Lys 
        35                  40                  45              


Leu Tyr His Lys 
    50          


<210> 451
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 451
Met Val Gln Leu Arg Pro Arg Ala Ser Arg 
1               5                   10  


<210> 452
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 452
Asn Asn Lys Leu Leu Ala Lys Arg Arg Lys Gly Gly Ala Ser Pro Lys 
1               5                   10                  15      


Asp Asp Pro Met Asp Asp Ile Lys 
            20                  


<210> 453
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 453
Asn Tyr Lys Arg Pro Met Asp Gly Thr Tyr Gly Pro Pro Ala Lys Arg 
1               5                   10                  15      


His Glu Gly Glu 
            20  


<210> 454
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 454
Pro Asp Thr Lys Arg Ala Lys Leu Asp Ser Ser Glu Thr Thr Met Val 
1               5                   10                  15      


Lys Lys Lys 
            


<210> 455
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 455
Pro Glu Lys Arg Thr Lys Ile 
1               5           


<210> 456
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 456
Pro Gly Gly Arg Gly Lys Lys Lys 
1               5               


<210> 457
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 457
Pro Gly Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg 
1               5                   10                  15      


Pro Tyr 
        


<210> 458
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 458
Pro Lys Lys Gly Asp Lys Tyr Asp Lys Thr Asp 
1               5                   10      


<210> 459
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 459
Pro Lys Lys Lys Ser Arg Lys 
1               5           


<210> 460
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 460
Pro Lys Lys Asn Lys Pro Glu 
1               5           


<210> 461
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 461
Pro Lys Lys Arg Ala Lys Val 
1               5           


<210> 462
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 462
Pro Lys Pro Lys Lys Leu Lys Val Glu 
1               5                   


<210> 463
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 463
Pro Lys Arg Gly Arg Gly Arg 
1               5           


<210> 464
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 464
Pro Lys Arg Arg Leu Val Asp Asp Ala 
1               5                   


<210> 465
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 465
Pro Lys Arg Arg Arg Thr Tyr 
1               5           


<210> 466
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 466
Pro Leu Phe Lys Arg Arg 
1               5       


<210> 467
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 467
Pro Leu Arg Lys Ala Lys Arg 
1               5           


<210> 468
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 468
Pro Pro Ala Lys Arg Lys Cys Ile Phe 
1               5                   


<210> 469
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 469
Pro Pro Ala Arg Arg Arg Arg Leu 
1               5               


<210> 470
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 470
Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


<210> 471
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 471
Pro Pro Asn Lys Arg Met Lys Val Lys His 
1               5                   10  


<210> 472
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 472
Pro Pro Arg Ile Tyr Pro Gln Leu Pro Ser Ala Pro Thr 
1               5                   10              


<210> 473
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 473
Pro Gln Arg Ser Pro Phe Pro Lys Ser Ser Val Lys Arg 
1               5                   10              


<210> 474
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 474
Pro Arg Pro Arg Lys Val Pro Arg 
1               5               


<210> 475
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 475
Pro Arg Arg Arg Val Gln Arg Lys Arg 
1               5                   


<210> 476
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 476
Pro Arg Arg Val Arg Leu Lys 
1               5           


<210> 477
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 477
Pro Ser Arg Lys Arg Pro Arg 
1               5           


<210> 478
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 478
Pro Ser Ser Lys Lys Arg Lys Val 
1               5               


<210> 479
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 479
Pro Thr Lys Lys Arg Val Lys 
1               5           


<210> 480
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 480
Gln Arg Pro Gly Pro Tyr Asp Arg Pro 
1               5                   


<210> 481
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 481
Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210> 482
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 482
Arg Lys Ala Gly Lys Gly Gly Gly Gly His Lys Thr Thr Lys Lys Arg 
1               5                   10                  15      


Ser Ala Lys Asp Glu Lys Val Pro 
            20                  


<210> 483
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 483
Arg Lys Ile Lys Leu Lys Arg Ala Lys 
1               5                   


<210> 484
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 484
Arg Lys Ile Lys Arg Lys Arg Ala Lys 
1               5                   


<210> 485
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 485
Arg Lys Lys Glu Ala Pro Gly Pro Arg Glu Glu Leu Arg Ser Arg Gly 
1               5                   10                  15      


Arg 
    


<210> 486
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 486
Arg Lys Lys Arg Lys Gly Lys 
1               5           


<210> 487
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 487
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210> 488
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 488
Arg Lys Lys Ser Ile Pro Leu Ser Ile Lys Asn Leu Lys Arg Lys His 
1               5                   10                  15      


Lys Arg Lys Lys Asn Lys Ile Thr Arg 
            20                  25  


<210> 489
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 489
Arg Lys Leu Val Lys Pro Lys Asn Thr Lys Met Lys Thr Lys Leu Arg 
1               5                   10                  15      


Thr Asn Pro Tyr 
            20  


<210> 490
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 490
Arg Lys Arg Leu Ile Leu Ser Asp Lys Gly Gln Leu Asp Trp Lys Lys 
1               5                   10                  15      


<210> 491
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 491
Arg Lys Arg Leu Lys Ser Lys 
1               5           


<210> 492
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 492
Arg Lys Arg Arg Val Arg Asp Asn Met 
1               5                   


<210> 493
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 493
Arg Lys Arg Ser Pro Lys Asp Lys Lys Glu Lys Asp Leu Asp Gly Ala 
1               5                   10                  15      


Gly Lys Arg Arg Lys Thr 
            20          


<210> 494
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 494
Arg Lys Arg Thr Pro Arg Val Asp Gly Gln Thr Gly Glu Asn Asp Met 
1               5                   10                  15      


Asn Lys Arg Arg Arg Lys 
            20          


<210> 495
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 495
Arg Leu Pro Val Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210> 496
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 496
Arg Leu Arg Phe Arg Lys Pro Lys Ser Lys 
1               5                   10  


<210> 497
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 497
Arg Gln Gln Arg Lys Arg 
1               5       


<210> 498
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 498
Arg Arg Asp Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys 
1               5                   10                  15      


<210> 499
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 499
Arg Arg Asp Arg Ala Lys Leu Arg 
1               5               


<210> 500
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 500
Arg Arg Gly Asp Gly Arg Arg Arg 
1               5               


<210> 501
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 501
Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln 
1               5                   10      


<210> 502
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 502
Arg Arg Lys Lys Arg Arg 
1               5       


<210> 503
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 503
Arg Arg Lys Arg Ser Lys Ser Glu Asp Met Asp Ser Val Glu Ser Lys 
1               5                   10                  15      


Arg Arg Arg 
            


<210> 504
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 504
Arg Arg Lys Arg Ser Arg 
1               5       


<210> 505
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 505
Arg Arg Pro Lys Gly Lys Thr Leu Gln Lys Arg Lys Pro Lys 
1               5                   10                  


<210> 506
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 506
Arg Arg Arg Gly Phe Glu Arg Phe Gly Pro Asp Asn Met Gly Arg Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 507
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 507
Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln Asn Cys Arg Lys 
1               5                   10                  15  


<210> 508
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 508
Arg Arg Arg Lys Arg Arg Asn Leu Ser 
1               5                   


<210> 509
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 509
Arg Arg Arg Gln Lys Gln Lys Gly Gly Ala Ser Arg Arg Arg 
1               5                   10                  


<210> 510
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 510
Arg Arg Arg Arg Glu Gly Pro Arg Ala Arg Arg Arg Arg 
1               5                   10              


<210> 511
<211> 61
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 511
Arg Arg Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser 
1               5                   10                  15      


Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe 
            20                  25                  30          


His Lys Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly 
        35                  40                  45              


Arg Met Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu 
    50                  55                  60      


<210> 512
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 512
Arg Arg Val Pro Gln Arg Lys Glu Val Ser Arg Cys Arg Lys Cys Arg 
1               5                   10                  15      


Lys 
    


<210> 513
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 513
Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu Leu 
1               5                   10                  15      


Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg Pro 
            20                  25                  30          


<210> 514
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 514
Arg Val Val Lys Leu Arg Ile Ala Pro 
1               5                   


<210> 515
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 515
Arg Val Val Arg Arg Arg 
1               5       


<210> 516
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 516
Ser Lys Arg Lys Thr Lys Ile Ser Arg Lys Thr Arg 
1               5                   10          


<210> 517
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 517
Ser Tyr Val Lys Thr Val Pro Asn Arg Thr Arg Thr Tyr Ile Lys Leu 
1               5                   10                  15      


<210> 518
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 518
Thr Gly Lys Asn Glu Ala Lys Lys Arg Lys Ile Ala 
1               5                   10          


<210> 519
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 519
Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser Val Ser Cys Pro Val Ile 
1               5                   10                  15      


Pro Ala Ser Thr Asp Glu Ser Pro Gly Ser Ala Leu Asn Ile 
            20                  25                  30  


<210> 520
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 520
Gly Ser Ser Ser Ser 
1               5   


<210> 521
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 521
Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
1               5                   10  


<210> 522
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 522
Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
1               5                   10                  15  


<210> 523
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 523
His His His His His His 
1               5       


