                               SEQUENCE LISTING

<110> PETRICHOR HEALTHCARE CAPITAL MANAGEMENT LP
 
<120> NUCLEAR PROTEIN TARGETING ENGINEERED DEUBIQUITINASES AND METHODS 
      OF USE THEREOF

<130> 723683-PHG-001PC

<140> PCT/US2021/058276
<141> 2021-11-05

<150> 63/110,616
<151> 2020-11-06

<160> 451   

<170> PatentIn version 3.5

<210> 1
<211> 438
<212> PRT
<213> Homo sapiens

<400> 1
Met Cys Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys 
1               5                   10                  15      


Glu Glu Gln Gly Glu Ala Leu Lys Leu Gln Ala Ser Thr Ser Thr Glu 
            20                  25                  30          


Val Ser His Gln Gln Cys Ser Val Pro Gly Leu Gly Glu Lys Phe Pro 
        35                  40                  45              


Thr Trp Glu Thr Thr Lys Pro Glu Leu Glu Leu Leu Gly His Asn Pro 
    50                  55                  60                  


Arg Arg Arg Arg Ile Thr Ser Ser Phe Thr Ile Gly Leu Arg Gly Leu 
65                  70                  75                  80  


Ile Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu 
                85                  90                  95      


Thr His Thr Pro Ile Leu Arg Asp Phe Phe Leu Ser Asp Arg His Arg 
            100                 105                 110         


Cys Glu Met Pro Ser Pro Glu Leu Cys Leu Val Cys Glu Met Ser Ser 
        115                 120                 125             


Leu Phe Arg Glu Leu Tyr Ser Gly Asn Pro Ser Pro His Val Pro Tyr 
    130                 135                 140                 


Lys Leu Leu His Leu Val Trp Ile His Ala Arg His Leu Ala Gly Tyr 
145                 150                 155                 160 


Arg Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp Val Leu 
                165                 170                 175     


His Arg His Cys Lys Gly Asp Asp Val Gly Lys Ala Ala Asn Asn Pro 
            180                 185                 190         


Asn His Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln 
        195                 200                 205             


Ser Asp Val Thr Cys Gln Ala Cys His Gly Val Ser Thr Thr Ile Asp 
    210                 215                 220                 


Pro Cys Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Thr Ser Phe 
225                 230                 235                 240 


Trp Pro Met Ser Pro Gly Arg Glu Ser Ser Val Asn Gly Glu Ser His 
                245                 250                 255     


Ile Pro Gly Ile Thr Thr Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg 
            260                 265                 270         


Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Gly Ser Cys Gln 
        275                 280                 285             


Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Asn Lys Leu Pro Val 
    290                 295                 300                 


Val Ala Cys Phe His Phe Lys Arg Phe Glu His Ser Ala Lys Gln Arg 
305                 310                 315                 320 


Arg Lys Ile Thr Thr Tyr Ile Ser Phe Pro Leu Glu Leu Asp Met Thr 
                325                 330                 335     


Pro Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly Gln Leu Gln 
            340                 345                 350         


Leu Pro Thr Asn Ser Gly Asn Asn Glu Asn Lys Tyr Ser Leu Phe Ala 
        355                 360                 365             


Val Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe 
    370                 375                 380                 


Ile Arg His His Lys Asp Gln Trp Phe Lys Cys Asp Asp Ala Val Ile 
385                 390                 395                 400 


Thr Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu 
                405                 410                 415     


Phe Tyr His Lys Gln Val Leu Glu His Glu Ser Glu Lys Val Lys Glu 
            420                 425                 430         


Met Asn Thr Gln Ala Tyr 
        435             


<210> 2
<211> 1035
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Pro Arg Leu Gln Leu Glu Lys Ala Ala Trp Arg Trp Ala Glu 
1               5                   10                  15      


Thr Val Arg Pro Glu Glu Val Ser Gln Glu His Ile Glu Thr Ala Tyr 
            20                  25                  30          


Arg Ile Trp Leu Glu Pro Cys Ile Arg Gly Val Cys Arg Arg Asn Cys 
        35                  40                  45              


Lys Gly Asn Pro Asn Cys Leu Val Gly Ile Gly Glu His Ile Trp Leu 
    50                  55                  60                  


Gly Glu Ile Asp Glu Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys 
65                  70                  75                  80  


Glu Arg Arg Lys Lys Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala 
                85                  90                  95      


Thr Cys Tyr Val Asn Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu 
            100                 105                 110         


Leu Arg Gln Ala Leu Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met 
        115                 120                 125             


Leu Gly Asp Gly Ile Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile 
    130                 135                 140                 


Cys Glu His Leu Gln Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg 
145                 150                 155                 160 


Arg Tyr Ile Asp Pro Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr 
                165                 170                 175     


Gly Gln Gln Gln Asp Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu 
            180                 185                 190         


Leu Glu Asp Thr Leu Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile 
        195                 200                 205             


Val Gln Gln Gln Phe Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn 
    210                 215                 220                 


Gln Cys Gly Arg Glu Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu 
225                 230                 235                 240 


Leu Asn Ile Gln Gly His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe 
                245                 250                 255     


Leu Lys Glu Glu Lys Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn 
            260                 265                 270         


Cys Gln Ser Lys Gln Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu 
        275                 280                 285             


Pro Cys Thr Leu Asn Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln 
    290                 295                 300                 


Thr Gly His Lys Lys Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile 
305                 310                 315                 320 


Leu Asp Met Glu Pro Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr 
                325                 330                 335     


Glu Leu Ser Ala Val Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly 
            340                 345                 350         


His Tyr Ile Ala His Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys 
        355                 360                 365             


Phe Asn Asp Glu Asp Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu 
    370                 375                 380                 


Gly Ile Glu Glu Asp Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys 
385                 390                 395                 400 


Pro Lys Cys Gly Lys Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu 
                405                 410                 415     


Val Tyr Arg Leu Gln Thr Gln Glu Lys Pro Asn Thr Thr Val Gln Val 
            420                 425                 430         


Pro Ala Phe Leu Gln Glu Leu Val Asp Arg Asp Asn Ser Lys Phe Glu 
        435                 440                 445             


Glu Trp Cys Ile Glu Met Ala Glu Met Arg Lys Gln Ser Val Asp Lys 
    450                 455                 460                 


Gly Lys Ala Lys His Glu Glu Val Lys Glu Leu Tyr Gln Arg Leu Pro 
465                 470                 475                 480 


Ala Gly Ala Glu Pro Tyr Glu Phe Val Ser Leu Glu Trp Leu Gln Lys 
                485                 490                 495     


Trp Leu Asp Glu Ser Thr Pro Thr Lys Pro Ile Asp Asn His Ala Cys 
            500                 505                 510         


Leu Cys Ser His Asp Lys Leu His Pro Asp Lys Ile Ser Ile Met Lys 
        515                 520                 525             


Arg Ile Ser Glu Tyr Ala Ala Asp Ile Phe Tyr Ser Arg Tyr Gly Gly 
    530                 535                 540                 


Gly Pro Arg Leu Thr Val Lys Ala Leu Cys Lys Glu Cys Val Val Glu 
545                 550                 555                 560 


Arg Cys Arg Ile Leu Arg Leu Lys Asn Gln Leu Asn Glu Asp Tyr Lys 
                565                 570                 575     


Thr Val Asn Asn Leu Leu Lys Ala Ala Val Lys Gly Ser Asp Gly Phe 
            580                 585                 590         


Trp Val Gly Lys Ser Ser Leu Arg Ser Trp Arg Gln Leu Ala Leu Glu 
        595                 600                 605             


Gln Leu Asp Glu Gln Asp Gly Asp Ala Glu Gln Ser Asn Gly Lys Met 
    610                 615                 620                 


Asn Gly Ser Thr Leu Asn Lys Asp Glu Ser Lys Glu Glu Arg Lys Glu 
625                 630                 635                 640 


Glu Glu Glu Leu Asn Phe Asn Glu Asp Ile Leu Cys Pro His Gly Glu 
                645                 650                 655     


Leu Cys Ile Ser Glu Asn Glu Arg Arg Leu Val Ser Lys Glu Ala Trp 
            660                 665                 670         


Ser Lys Leu Gln Gln Tyr Phe Pro Lys Ala Pro Glu Phe Pro Ser Tyr 
        675                 680                 685             


Lys Glu Cys Cys Ser Gln Cys Lys Ile Leu Glu Arg Glu Gly Glu Glu 
    690                 695                 700                 


Asn Glu Ala Leu His Lys Met Ile Ala Asn Glu Gln Lys Thr Ser Leu 
705                 710                 715                 720 


Pro Asn Leu Phe Gln Asp Lys Asn Arg Pro Cys Leu Ser Asn Trp Pro 
                725                 730                 735     


Glu Asp Thr Asp Val Leu Tyr Ile Val Ser Gln Phe Phe Val Glu Glu 
            740                 745                 750         


Trp Arg Lys Phe Val Arg Lys Pro Thr Arg Cys Ser Pro Val Ser Ser 
        755                 760                 765             


Val Gly Asn Ser Ala Leu Leu Cys Pro His Gly Gly Leu Met Phe Thr 
    770                 775                 780                 


Phe Ala Ser Met Thr Lys Glu Asp Ser Lys Leu Ile Ala Leu Ile Trp 
785                 790                 795                 800 


Pro Ser Glu Trp Gln Met Ile Gln Lys Leu Phe Val Val Asp His Val 
                805                 810                 815     


Ile Lys Ile Thr Arg Ile Glu Val Gly Asp Val Asn Pro Ser Glu Thr 
            820                 825                 830         


Gln Tyr Ile Ser Glu Pro Lys Leu Cys Pro Glu Cys Arg Glu Gly Leu 
        835                 840                 845             


Leu Cys Gln Gln Gln Arg Asp Leu Arg Glu Tyr Thr Gln Ala Thr Ile 
    850                 855                 860                 


Tyr Val His Lys Val Val Asp Asn Lys Lys Val Met Lys Asp Ser Ala 
865                 870                 875                 880 


Pro Glu Leu Asn Val Ser Ser Ser Glu Thr Glu Glu Asp Lys Glu Glu 
                885                 890                 895     


Ala Lys Pro Asp Gly Glu Lys Asp Pro Asp Phe Asn Gln Ser Asn Gly 
            900                 905                 910         


Gly Thr Lys Arg Gln Lys Ile Ser His Gln Asn Tyr Ile Ala Tyr Gln 
        915                 920                 925             


Lys Gln Val Ile Arg Arg Ser Met Arg His Arg Lys Val Arg Gly Glu 
    930                 935                 940                 


Lys Ala Leu Leu Val Ser Ala Asn Gln Thr Leu Lys Glu Leu Lys Ile 
945                 950                 955                 960 


Gln Ile Met His Ala Phe Ser Val Ala Pro Phe Asp Gln Asn Leu Ser 
                965                 970                 975     


Ile Asp Gly Lys Ile Leu Ser Asp Asp Cys Ala Thr Leu Gly Thr Leu 
            980                 985                 990         


Gly Val Ile Pro Glu Ser Val Ile  Leu Leu Lys Ala Asp  Glu Pro Ile 
        995                 1000                 1005             


Ala Asp  Tyr Ala Ala Met Asp  Asp Val Met Gln Val  Cys Met Pro 
    1010                 1015                 1020             


Glu Glu  Gly Phe Lys Gly Thr  Gly Leu Leu Gly His  
    1025                 1030                 1035 


<210> 3
<211> 520
<212> PRT
<213> Homo sapiens

<400> 3
Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser 
1               5                   10                  15      


Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys 
            20                  25                  30          


Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His 
        35                  40                  45              


Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala 
    50                  55                  60                  


Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val 
65                  70                  75                  80  


Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr 
                85                  90                  95      


Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln 
            100                 105                 110         


Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala 
        115                 120                 125             


Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly 
145                 150                 155                 160 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser 
                165                 170                 175     


Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala 
            180                 185                 190         


Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr 
        195                 200                 205             


Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys 
    210                 215                 220                 


Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr 
                245                 250                 255     


Gln Gln Gln Asp Ala His Glu Phe Met Arg Tyr Leu Leu Asp His Leu 
            260                 265                 270         


His Leu Glu Leu Gln Gly Gly Phe Asn Gly Val Ser Arg Ser Ala Ile 
        275                 280                 285             


Leu Gln Glu Asn Ser Thr Leu Ser Ala Ser Asn Lys Cys Cys Ile Asn 
    290                 295                 300                 


Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln Asn 
305                 310                 315                 320 


Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys Arg 
            340                 345                 350         


Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu 
        355                 360                 365             


Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met 
    370                 375                 380                 


Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp Ile 
385                 390                 395                 400 


Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp 
                405                 410                 415     


Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu 
            420                 425                 430         


Arg Gly Leu Asp Met Lys Cys Tyr Leu Leu Glu Pro Glu Asn Ser Gly 
        435                 440                 445             


Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly 
    450                 455                 460                 


Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly 
465                 470                 475                 480 


Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu 
                485                 490                 495     


Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His Gln 
            500                 505                 510         


Ala Lys Ala Gly Ser Asp Lys Leu 
        515                 520 


<210> 4
<211> 470
<212> PRT
<213> Homo sapiens

<400> 4
Gln Leu Ala Pro Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala 
1               5                   10                  15      


Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
            20                  25                  30          


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
        35                  40                  45              


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
    50                  55                  60                  


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
65                  70                  75                  80  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
                85                  90                  95      


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
            100                 105                 110         


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
        115                 120                 125             


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
    130                 135                 140                 


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
145                 150                 155                 160 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
                165                 170                 175     


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
            180                 185                 190         


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
        195                 200                 205             


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
    210                 215                 220                 


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
225                 230                 235                 240 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
                245                 250                 255     


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
            260                 265                 270         


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
        275                 280                 285             


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
    290                 295                 300                 


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
305                 310                 315                 320 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
                325                 330                 335     


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
            340                 345                 350         


Pro Cys Leu Gln Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala 
        355                 360                 365             


Thr Gln Glu Ser Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn 
    370                 375                 380                 


Lys Thr Lys Pro Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro 
385                 390                 395                 400 


Pro Asp Val Leu Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys 
                405                 410                 415     


Asn His His Pro Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr 
            420                 425                 430         


Thr Pro Thr His Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu 
        435                 440                 445             


Arg Gly Arg Ala Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg 
    450                 455                 460                 


Ala Leu Leu Val Cys Gln 
465                 470 


<210> 5
<211> 785
<212> PRT
<213> Homo sapiens

<400> 5
Met Pro Gly Val Ile Pro Ser Glu Ser Asn Gly Leu Ser Arg Gly Ser 
1               5                   10                  15      


Pro Ser Lys Lys Asn Arg Leu Ser Leu Lys Phe Phe Gln Lys Lys Glu 
            20                  25                  30          


Thr Lys Arg Ala Leu Asp Phe Thr Asp Ser Gln Glu Asn Glu Glu Lys 
        35                  40                  45              


Ala Ser Glu Tyr Arg Ala Ser Glu Ile Asp Gln Val Val Pro Ala Ala 
    50                  55                  60                  


Gln Ser Ser Pro Ile Asn Cys Glu Lys Arg Glu Asn Leu Leu Pro Phe 
65                  70                  75                  80  


Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn Ser Ile Leu 
                85                  90                  95      


Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val Lys His Leu 
            100                 105                 110         


Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp Glu Ala Asn 
        115                 120                 125             


Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala Ser Tyr Glu 
    130                 135                 140                 


Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu Gln Leu Gln 
145                 150                 155                 160 


Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu Leu Ala Thr 
                165                 170                 175     


Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn Pro Met Tyr 
            180                 185                 190         


Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln Cys Ile Leu 
        195                 200                 205             


Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu Glu Val Lys 
    210                 215                 220                 


Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro His Pro Lys 
225                 230                 235                 240 


Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser Met Arg His 
                245                 250                 255     


Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly Lys Arg Lys 
            260                 265                 270         


Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys Leu Ser Lys 
        275                 280                 285             


Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg Ser Lys Arg 
    290                 295                 300                 


Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile Ile Pro Lys 
305                 310                 315                 320 


Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys Lys Ser Arg 
                325                 330                 335     


Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro Ser Ile Leu 
            340                 345                 350         


Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln Gly Val Lys 
        355                 360                 365             


Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp Leu Gly Lys 
    370                 375                 380                 


Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu Ser Pro Gly 
385                 390                 395                 400 


Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro Ile Asn Lys 
                405                 410                 415     


Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu Phe Gln Gly 
            420                 425                 430         


Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser Leu Thr Glu 
        435                 440                 445             


Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln Glu Asp Glu 
    450                 455                 460                 


Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu Pro Lys Thr 
465                 470                 475                 480 


Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala Ser Val Glu 
                485                 490                 495     


Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys His His Tyr 
            500                 505                 510         


Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro Glu Val Ile 
        515                 520                 525             


Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu Phe Asp Cys 
    530                 535                 540                 


Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu Thr Pro Leu 
545                 550                 555                 560 


Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn Asp Ser Tyr 
                565                 570                 575     


Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile Ser Ser Gly 
            580                 585                 590         


His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser Leu Glu Leu 
        595                 600                 605             


Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Ile Gly Lys Pro 
    610                 615                 620                 


Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu Asn Tyr Asn 
625                 630                 635                 640 


Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln Pro Ser Lys 
                645                 650                 655     


Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu Gly Gly Gln 
            660                 665                 670         


Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser Asn Pro Asp 
        675                 680                 685             


Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser Glu Thr Ser 
    690                 695                 700                 


Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu Ser Ser Asp 
705                 710                 715                 720 


Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile Ser Tyr Val 
                725                 730                 735     


Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu Phe Asp Asp 
            740                 745                 750         


Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn Ser Leu Ser 
        755                 760                 765             


Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe Tyr Lys Lys 
    770                 775                 780                 


Leu 
785 


<210> 6
<211> 1235
<212> PRT
<213> Homo sapiens

<400> 6
Met Phe Gly Asp Leu Phe Glu Glu Glu Tyr Ser Thr Val Ser Asn Asn 
1               5                   10                  15      


Gln Tyr Gly Lys Gly Lys Lys Leu Lys Thr Lys Ala Leu Glu Pro Pro 
            20                  25                  30          


Ala Pro Arg Glu Phe Thr Asn Leu Ser Gly Ile Arg Asn Gln Gly Gly 
        35                  40                  45              


Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu His Phe Thr Pro Glu 
    50                  55                  60                  


Phe Arg Glu Ala Leu Phe Ser Leu Gly Pro Glu Glu Leu Gly Leu Phe 
65                  70                  75                  80  


Glu Asp Lys Asp Lys Pro Asp Ala Lys Val Arg Ile Ile Pro Leu Gln 
                85                  90                  95      


Leu Gln Arg Leu Phe Ala Gln Leu Leu Leu Leu Asp Gln Glu Ala Ala 
            100                 105                 110         


Ser Thr Ala Asp Leu Thr Asp Ser Phe Gly Trp Thr Ser Asn Glu Glu 
        115                 120                 125             


Met Arg Gln His Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala 
    130                 135                 140                 


Leu Glu Thr Ser Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg 
145                 150                 155                 160 


Leu Tyr His Gly Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys 
                165                 170                 175     


Asn Val Ser Glu Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val 
            180                 185                 190         


Lys Asn Val Ser Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu 
        195                 200                 205             


Glu Glu Val Phe Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp 
    210                 215                 220                 


Arg Leu Val Lys Ala Ala Lys Ser Ala Lys Leu Arg Lys Leu Pro Pro 
225                 230                 235                 240 


Phe Leu Thr Val Ser Leu Leu Arg Phe Asn Phe Asp Phe Val Lys Cys 
                245                 250                 255     


Glu Arg Tyr Lys Glu Thr Ser Cys Tyr Thr Phe Pro Leu Arg Ile Asn 
            260                 265                 270         


Leu Lys Pro Phe Cys Glu Gln Ser Glu Leu Asp Asp Leu Glu Tyr Ile 
        275                 280                 285             


Tyr Asp Leu Phe Ser Val Ile Ile His Lys Gly Gly Cys Tyr Gly Gly 
    290                 295                 300                 


His Tyr His Val Tyr Ile Lys Asp Val Asp His Leu Gly Asn Trp Gln 
305                 310                 315                 320 


Phe Gln Glu Glu Lys Ser Lys Pro Asp Val Asn Leu Lys Asp Leu Gln 
                325                 330                 335     


Ser Glu Glu Glu Ile Asp His Pro Leu Met Ile Leu Lys Ala Ile Leu 
            340                 345                 350         


Leu Glu Glu Asn Asn Leu Ile Pro Val Asp Gln Leu Gly Gln Lys Leu 
        355                 360                 365             


Leu Lys Lys Ile Gly Ile Ser Trp Asn Lys Lys Tyr Arg Lys Gln His 
    370                 375                 380                 


Gly Pro Leu Arg Lys Phe Leu Gln Leu His Ser Gln Ile Phe Leu Leu 
385                 390                 395                 400 


Ser Ser Asp Glu Ser Thr Val Arg Leu Leu Lys Asn Ser Ser Leu Gln 
                405                 410                 415     


Ala Glu Ser Asp Phe Gln Arg Asn Asp Gln Gln Ile Phe Lys Met Leu 
            420                 425                 430         


Pro Pro Glu Ser Pro Gly Leu Asn Asn Ser Ile Ser Cys Pro His Trp 
        435                 440                 445             


Phe Asp Ile Asn Asp Ser Lys Val Gln Pro Ile Arg Glu Lys Asp Ile 
    450                 455                 460                 


Glu Gln Gln Phe Gln Gly Lys Glu Ser Ala Tyr Met Leu Phe Tyr Arg 
465                 470                 475                 480 


Lys Ser Gln Leu Gln Arg Pro Pro Glu Ala Arg Ala Asn Pro Arg Tyr 
                485                 490                 495     


Gly Val Pro Cys His Leu Leu Asn Glu Met Asp Ala Ala Asn Ile Glu 
            500                 505                 510         


Leu Gln Thr Lys Arg Ala Glu Cys Asp Ser Ala Asn Asn Thr Phe Glu 
        515                 520                 525             


Leu His Leu His Leu Gly Pro Gln Tyr His Phe Phe Asn Gly Ala Leu 
    530                 535                 540                 


His Pro Val Val Ser Gln Thr Glu Ser Val Trp Asp Leu Thr Phe Asp 
545                 550                 555                 560 


Lys Arg Lys Thr Leu Gly Asp Leu Arg Gln Ser Ile Phe Gln Leu Leu 
                565                 570                 575     


Glu Phe Trp Glu Gly Asp Met Val Leu Ser Val Ala Lys Leu Val Pro 
            580                 585                 590         


Ala Gly Leu His Ile Tyr Gln Ser Leu Gly Gly Asp Glu Leu Thr Leu 
        595                 600                 605             


Cys Glu Thr Glu Ile Ala Asp Gly Glu Asp Ile Phe Val Trp Asn Gly 
    610                 615                 620                 


Val Glu Val Gly Gly Val His Ile Gln Thr Gly Ile Asp Cys Glu Pro 
625                 630                 635                 640 


Leu Leu Leu Asn Val Leu His Leu Asp Thr Ser Ser Asp Gly Glu Lys 
                645                 650                 655     


Cys Cys Gln Val Ile Glu Ser Pro His Val Phe Pro Ala Asn Ala Glu 
            660                 665                 670         


Val Gly Thr Val Leu Thr Ala Leu Ala Ile Pro Ala Gly Val Ile Phe 
        675                 680                 685             


Ile Asn Ser Ala Gly Cys Pro Gly Gly Glu Gly Trp Thr Ala Ile Pro 
    690                 695                 700                 


Lys Glu Asp Met Arg Lys Thr Phe Arg Glu Gln Gly Leu Arg Asn Gly 
705                 710                 715                 720 


Ser Ser Ile Leu Ile Gln Asp Ser His Asp Asp Asn Ser Leu Leu Thr 
                725                 730                 735     


Lys Glu Glu Lys Trp Val Thr Ser Met Asn Glu Ile Asp Trp Leu His 
            740                 745                 750         


Val Lys Asn Leu Cys Gln Leu Glu Ser Glu Glu Lys Gln Val Lys Ile 
        755                 760                 765             


Ser Ala Thr Val Asn Thr Met Val Phe Asp Ile Arg Ile Lys Ala Ile 
    770                 775                 780                 


Lys Glu Leu Lys Leu Met Lys Glu Leu Ala Asp Asn Ser Cys Leu Arg 
785                 790                 795                 800 


Pro Ile Asp Arg Asn Gly Lys Leu Leu Cys Pro Val Pro Asp Ser Tyr 
                805                 810                 815     


Thr Leu Lys Glu Ala Glu Leu Lys Met Gly Ser Ser Leu Gly Leu Cys 
            820                 825                 830         


Leu Gly Lys Ala Pro Ser Ser Ser Gln Leu Phe Leu Phe Phe Ala Met 
        835                 840                 845             


Gly Ser Asp Val Gln Pro Gly Thr Glu Met Glu Ile Val Val Glu Glu 
    850                 855                 860                 


Thr Ile Ser Val Arg Asp Cys Leu Lys Leu Met Leu Lys Lys Ser Gly 
865                 870                 875                 880 


Leu Gln Gly Asp Ala Trp His Leu Arg Lys Met Asp Trp Cys Tyr Glu 
                885                 890                 895     


Ala Gly Glu Pro Leu Cys Glu Glu Asp Ala Thr Leu Lys Glu Leu Leu 
            900                 905                 910         


Ile Cys Ser Gly Asp Thr Leu Leu Leu Ile Glu Gly Gln Leu Pro Pro 
        915                 920                 925             


Leu Gly Phe Leu Lys Val Pro Ile Trp Trp Tyr Gln Leu Gln Gly Pro 
    930                 935                 940                 


Ser Gly His Trp Glu Ser His Gln Asp Gln Thr Asn Cys Thr Ser Ser 
945                 950                 955                 960 


Trp Gly Arg Val Trp Arg Ala Thr Ser Ser Gln Gly Ala Ser Gly Asn 
                965                 970                 975     


Glu Pro Ala Gln Val Ser Leu Leu Tyr Leu Gly Asp Ile Glu Ile Ser 
            980                 985                 990         


Glu Asp Ala Thr Leu Ala Glu Leu  Lys Ser Gln Ala Met  Thr Leu Pro 
        995                 1000                 1005             


Pro Phe  Leu Glu Phe Gly Val  Pro Ser Pro Ala His  Leu Arg Ala 
    1010                 1015                 1020             


Trp Thr  Val Glu Arg Lys Arg  Pro Gly Arg Leu Leu  Arg Thr Asp 
    1025                 1030                 1035             


Arg Gln  Pro Leu Arg Glu Tyr  Lys Leu Gly Arg Arg  Ile Glu Ile 
    1040                 1045                 1050             


Cys Leu  Glu Pro Leu Gln Lys  Gly Glu Asn Leu Gly  Pro Gln Asp 
    1055                 1060                 1065             


Val Leu  Leu Arg Thr Gln Val  Arg Ile Pro Gly Glu  Arg Thr Tyr 
    1070                 1075                 1080             


Ala Pro  Ala Leu Asp Leu Val  Trp Asn Ala Ala Gln  Gly Gly Thr 
    1085                 1090                 1095             


Ala Gly  Ser Leu Arg Gln Arg  Val Ala Asp Phe Tyr  Arg Leu Pro 
    1100                 1105                 1110             


Val Glu  Lys Ile Glu Ile Ala  Lys Tyr Phe Pro Glu  Lys Phe Glu 
    1115                 1120                 1125             


Trp Leu  Pro Ile Ser Ser Trp  Asn Gln Gln Ile Thr  Lys Arg Lys 
    1130                 1135                 1140             


Lys Lys  Lys Lys Gln Asp Tyr  Leu Gln Gly Ala Pro  Tyr Tyr Leu 
    1145                 1150                 1155             


Lys Asp  Gly Asp Thr Ile Gly  Val Lys Asn Leu Leu  Ile Asp Asp 
    1160                 1165                 1170             


Asp Asp  Asp Phe Ser Thr Ile  Arg Asp Asp Thr Gly  Lys Glu Lys 
    1175                 1180                 1185             


Gln Lys  Gln Arg Ala Leu Gly  Arg Arg Lys Ser Gln  Glu Ala Leu 
    1190                 1195                 1200             


His Glu  Gln Ser Ser Tyr Ile  Leu Ser Ser Ala Glu  Thr Pro Ala 
    1205                 1210                 1215             


Arg Pro  Arg Ala Pro Glu Thr  Ser Leu Ser Ile His  Val Gly Ser 
    1220                 1225                 1230             


Phe Arg  
    1235 


<210> 7
<211> 1102
<212> PRT
<213> Homo sapiens

<400> 7
Met Asn His Gln Gln Gln Gln Gln Gln Gln Lys Ala Gly Glu Gln Gln 
1               5                   10                  15      


Leu Ser Glu Pro Glu Asp Met Glu Met Glu Ala Gly Asp Thr Asp Asp 
            20                  25                  30          


Pro Pro Arg Ile Thr Gln Asn Pro Val Ile Asn Gly Asn Val Ala Leu 
        35                  40                  45              


Ser Asp Gly His Asn Thr Ala Glu Glu Asp Met Glu Asp Asp Thr Ser 
    50                  55                  60                  


Trp Arg Ser Glu Ala Thr Phe Gln Phe Thr Val Glu Arg Phe Ser Arg 
65                  70                  75                  80  


Leu Ser Glu Ser Val Leu Ser Pro Pro Cys Phe Val Arg Asn Leu Pro 
                85                  90                  95      


Trp Lys Ile Met Val Met Pro Arg Phe Tyr Pro Asp Arg Pro His Gln 
            100                 105                 110         


Lys Ser Val Gly Phe Phe Leu Gln Cys Asn Ala Glu Ser Asp Ser Thr 
        115                 120                 125             


Ser Trp Ser Cys His Ala Gln Ala Val Leu Lys Ile Ile Asn Tyr Arg 
    130                 135                 140                 


Asp Asp Glu Lys Ser Phe Ser Arg Arg Ile Ser His Leu Phe Phe His 
145                 150                 155                 160 


Lys Glu Asn Asp Trp Gly Phe Ser Asn Phe Met Ala Trp Ser Glu Val 
                165                 170                 175     


Thr Asp Pro Glu Lys Gly Phe Ile Asp Asp Asp Lys Val Thr Phe Glu 
            180                 185                 190         


Val Phe Val Gln Ala Asp Ala Pro His Gly Val Ala Trp Asp Ser Lys 
        195                 200                 205             


Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr 
    210                 215                 220                 


Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys 
225                 230                 235                 240 


Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val 
                245                 250                 255     


Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys 
            260                 265                 270         


Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu 
        275                 280                 285             


Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu 
    290                 295                 300                 


Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile 
305                 310                 315                 320 


Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu 
                325                 330                 335     


Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu 
            340                 345                 350         


Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val 
        355                 360                 365             


Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His 
    370                 375                 380                 


Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro 
385                 390                 395                 400 


Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp 
                405                 410                 415     


Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro 
            420                 425                 430         


Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr 
        435                 440                 445             


Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His 
    450                 455                 460                 


Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe 
465                 470                 475                 480 


Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His 
                485                 490                 495     


Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn 
            500                 505                 510         


Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser Glu Val Leu 
        515                 520                 525             


Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val Glu Arg Leu 
    530                 535                 540                 


Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg Lys Glu Arg Gln Glu 
545                 550                 555                 560 


Ala His Leu Tyr Met Gln Val Gln Ile Val Ala Glu Asp Gln Phe Cys 
                565                 570                 575     


Gly His Gln Gly Asn Asp Met Tyr Asp Glu Glu Lys Val Lys Tyr Thr 
            580                 585                 590         


Val Phe Lys Val Leu Lys Asn Ser Ser Leu Ala Glu Phe Val Gln Ser 
        595                 600                 605             


Leu Ser Gln Thr Met Gly Phe Pro Gln Asp Gln Ile Arg Leu Trp Pro 
    610                 615                 620                 


Met Gln Ala Arg Ser Asn Gly Thr Lys Arg Pro Ala Met Leu Asp Asn 
625                 630                 635                 640 


Glu Ala Asp Gly Asn Lys Thr Met Ile Glu Leu Ser Asp Asn Glu Asn 
                645                 650                 655     


Pro Trp Thr Ile Phe Leu Glu Thr Val Asp Pro Glu Leu Ala Ala Ser 
            660                 665                 670         


Gly Ala Thr Leu Pro Lys Phe Asp Lys Asp His Asp Val Met Leu Phe 
        675                 680                 685             


Leu Lys Met Tyr Asp Pro Lys Thr Arg Ser Leu Asn Tyr Cys Gly His 
    690                 695                 700                 


Ile Tyr Thr Pro Ile Ser Cys Lys Ile Arg Asp Leu Leu Pro Val Met 
705                 710                 715                 720 


Cys Asp Arg Ala Gly Phe Ile Gln Asp Thr Ser Leu Ile Leu Tyr Glu 
                725                 730                 735     


Glu Val Lys Pro Asn Leu Thr Glu Arg Ile Gln Asp Tyr Asp Val Ser 
            740                 745                 750         


Leu Asp Lys Ala Leu Asp Glu Leu Met Asp Gly Asp Ile Ile Val Phe 
        755                 760                 765             


Gln Lys Asp Asp Pro Glu Asn Asp Asn Ser Glu Leu Pro Thr Ala Lys 
    770                 775                 780                 


Glu Tyr Phe Arg Asp Leu Tyr His Arg Val Asp Val Ile Phe Cys Asp 
785                 790                 795                 800 


Lys Thr Ile Pro Asn Asp Pro Gly Phe Val Val Thr Leu Ser Asn Arg 
                805                 810                 815     


Met Asn Tyr Phe Gln Val Ala Lys Thr Val Ala Gln Arg Leu Asn Thr 
            820                 825                 830         


Asp Pro Met Leu Leu Gln Phe Phe Lys Ser Gln Gly Tyr Arg Asp Gly 
        835                 840                 845             


Pro Gly Asn Pro Leu Arg His Asn Tyr Glu Gly Thr Leu Arg Asp Leu 
    850                 855                 860                 


Leu Gln Phe Phe Lys Pro Arg Gln Pro Lys Lys Leu Tyr Tyr Gln Gln 
865                 870                 875                 880 


Leu Lys Met Lys Ile Thr Asp Phe Glu Asn Arg Arg Ser Phe Lys Cys 
                885                 890                 895     


Ile Trp Leu Asn Ser Gln Phe Arg Glu Glu Glu Ile Thr Leu Tyr Pro 
            900                 905                 910         


Asp Lys His Gly Cys Val Arg Asp Leu Leu Glu Glu Cys Lys Lys Ala 
        915                 920                 925             


Val Glu Leu Gly Glu Lys Ala Ser Gly Lys Leu Arg Leu Leu Glu Ile 
    930                 935                 940                 


Val Ser Tyr Lys Ile Ile Gly Val His Gln Glu Asp Glu Leu Leu Glu 
945                 950                 955                 960 


Cys Leu Ser Pro Ala Thr Ser Arg Thr Phe Arg Ile Glu Glu Ile Pro 
                965                 970                 975     


Leu Asp Gln Val Asp Ile Asp Lys Glu Asn Glu Met Leu Val Thr Val 
            980                 985                 990         


Ala His Phe His Lys Glu Val Phe  Gly Thr Phe Gly Ile  Pro Phe Leu 
        995                 1000                 1005             


Leu Arg  Ile His Gln Gly Glu  His Phe Arg Glu Val  Met Lys Arg 
    1010                 1015                 1020             


Ile Gln  Ser Leu Leu Asp Ile  Gln Glu Lys Glu Phe  Glu Lys Phe 
    1025                 1030                 1035             


Lys Phe  Ala Ile Val Met Met  Gly Arg His Gln Tyr  Ile Asn Glu 
    1040                 1045                 1050             


Asp Glu  Tyr Glu Val Asn Leu  Lys Asp Phe Glu Pro  Gln Pro Gly 
    1055                 1060                 1065             


Asn Met  Ser His Pro Arg Pro  Trp Leu Gly Leu Asp  His Phe Asn 
    1070                 1075                 1080             


Lys Ala  Pro Lys Arg Ser Arg  Tyr Thr Tyr Leu Glu  Lys Ala Ile 
    1085                 1090                 1095             


Lys Ile  His Asn 
    1100         


<210> 8
<211> 530
<212> PRT
<213> Homo sapiens

<400> 8
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Ala Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 9
<211> 530
<212> PRT
<213> Homo sapiens

<400> 9
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Asn Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr Leu Leu Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 10
<211> 530
<212> PRT
<213> Homo sapiens

<400> 10
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Pro Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Lys Pro Pro Leu Ala Asn Tyr Met Leu Phe Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Ile Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Arg Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp Arg His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Asn Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Pro Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Ser 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Val Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Arg Val Glu Gly Thr Val Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Arg Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 11
<211> 358
<212> PRT
<213> Homo sapiens

<400> 11
Met Asp Gly Val Leu Phe Arg Ala His Gln Cys Gln Tyr Val His Pro 
1               5                   10                  15      


Cys Val His Val Tyr Val Thr Val Gly Leu Met Asp Pro Leu Cys Glu 
            20                  25                  30          


Arg Lys Glu Lys Ala Ser Lys Gln Glu Arg Glu Asn Pro Leu Ala His 
        35                  40                  45              


Leu Ala Ala Trp Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Ala 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Trp Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Tyr Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Ala Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Met Ile Arg Met Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Leu Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Arg Leu Ser Phe Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp 
        355             


<210> 12
<211> 1042
<212> PRT
<213> Homo sapiens

<400> 12
Met Asp Lys Ile Leu Glu Gly Leu Val Ser Ser Ser His Pro Leu Pro 
1               5                   10                  15      


Leu Lys Arg Val Ile Val Arg Lys Val Val Glu Ser Ala Glu His Trp 
            20                  25                  30          


Leu Asp Glu Ala Gln Cys Glu Ala Met Phe Asp Leu Thr Thr Arg Leu 
        35                  40                  45              


Ile Leu Glu Gly Gln Asp Pro Phe Gln Arg Gln Val Gly His Gln Val 
    50                  55                  60                  


Leu Glu Ala Tyr Ala Arg Tyr His Arg Pro Glu Phe Glu Ser Phe Phe 
65                  70                  75                  80  


Asn Lys Thr Phe Val Leu Gly Leu Leu His Gln Gly Tyr His Ser Leu 
                85                  90                  95      


Asp Arg Lys Asp Val Ala Ile Leu Asp Tyr Ile His Asn Gly Leu Lys 
            100                 105                 110         


Leu Ile Met Ser Cys Pro Ser Val Leu Asp Leu Phe Ser Leu Leu Gln 
        115                 120                 125             


Val Glu Val Leu Arg Met Val Cys Glu Arg Pro Glu Pro Gln Leu Cys 
    130                 135                 140                 


Ala Arg Leu Ser Asp Leu Leu Thr Asp Phe Val Gln Cys Ile Pro Lys 
145                 150                 155                 160 


Gly Lys Leu Ser Ile Thr Phe Cys Gln Gln Leu Val Arg Thr Ile Gly 
                165                 170                 175     


His Phe Gln Cys Val Ser Thr Gln Glu Arg Glu Leu Arg Glu Tyr Val 
            180                 185                 190         


Ser Gln Val Thr Lys Val Ser Asn Leu Leu Gln Asn Ile Trp Lys Ala 
        195                 200                 205             


Glu Pro Ala Thr Leu Leu Pro Ser Leu Gln Glu Val Phe Ala Ser Ile 
    210                 215                 220                 


Ser Ser Thr Asp Ala Ser Phe Glu Pro Ser Val Ala Leu Ala Ser Leu 
225                 230                 235                 240 


Val Gln His Ile Pro Leu Gln Met Ile Thr Val Leu Ile Arg Ser Leu 
                245                 250                 255     


Thr Thr Asp Pro Asn Val Lys Asp Ala Ser Met Thr Gln Ala Leu Cys 
            260                 265                 270         


Arg Met Ile Asp Trp Leu Ser Trp Pro Leu Ala Gln His Val Asp Thr 
        275                 280                 285             


Trp Val Ile Ala Leu Leu Lys Gly Leu Ala Ala Val Gln Lys Phe Thr 
    290                 295                 300                 


Ile Leu Ile Asp Val Thr Leu Leu Lys Ile Glu Leu Val Phe Asn Arg 
305                 310                 315                 320 


Leu Trp Phe Pro Leu Val Arg Pro Gly Ala Leu Ala Val Leu Ser His 
                325                 330                 335     


Met Leu Leu Ser Phe Gln His Ser Pro Glu Ala Phe His Leu Ile Val 
            340                 345                 350         


Pro His Val Val Asn Leu Val His Ser Phe Lys Asn Asp Gly Leu Pro 
        355                 360                 365             


Ser Ser Thr Ala Phe Leu Val Gln Leu Thr Glu Leu Ile His Cys Met 
    370                 375                 380                 


Met Tyr His Tyr Ser Gly Phe Pro Asp Leu Tyr Glu Pro Ile Leu Glu 
385                 390                 395                 400 


Ala Ile Lys Asp Phe Pro Lys Pro Ser Glu Glu Lys Ile Lys Leu Ile 
                405                 410                 415     


Leu Asn Gln Ser Ala Trp Thr Ser Gln Ser Asn Ser Leu Ala Ser Cys 
            420                 425                 430         


Leu Ser Arg Leu Ser Gly Lys Ser Glu Thr Gly Lys Thr Gly Leu Ile 
        435                 440                 445             


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Val Ile Gln Ala Leu Phe 
    450                 455                 460                 


Met Ala Thr Asp Phe Arg Arg Gln Val Leu Ser Leu Asn Leu Asn Gly 
465                 470                 475                 480 


Cys Asn Ser Leu Met Lys Lys Leu Gln His Leu Phe Ala Phe Leu Ala 
                485                 490                 495     


His Thr Gln Arg Glu Ala Tyr Ala Pro Arg Ile Phe Phe Glu Ala Ser 
            500                 505                 510         


Arg Pro Pro Trp Phe Thr Pro Arg Ser Gln Gln Asp Cys Ser Glu Tyr 
        515                 520                 525             


Leu Arg Phe Leu Leu Asp Arg Leu His Glu Glu Glu Lys Ile Leu Lys 
    530                 535                 540                 


Val Gln Ala Ser His Lys Pro Ser Glu Ile Leu Glu Cys Ser Glu Thr 
545                 550                 555                 560 


Ser Leu Gln Glu Val Ala Ser Lys Ala Ala Val Leu Thr Glu Thr Pro 
                565                 570                 575     


Arg Thr Ser Asp Gly Glu Lys Thr Leu Ile Glu Lys Met Phe Gly Gly 
            580                 585                 590         


Lys Leu Arg Thr His Ile Arg Cys Leu Asn Cys Arg Ser Thr Ser Gln 
        595                 600                 605             


Lys Val Glu Ala Phe Thr Asp Leu Ser Leu Ala Phe Cys Pro Ser Ser 
    610                 615                 620                 


Ser Leu Glu Asn Met Ser Val Gln Asp Pro Ala Ser Ser Pro Ser Ile 
625                 630                 635                 640 


Gln Asp Gly Gly Leu Met Gln Ala Ser Val Pro Gly Pro Ser Glu Glu 
                645                 650                 655     


Pro Val Val Tyr Asn Pro Thr Thr Ala Ala Phe Ile Cys Asp Ser Leu 
            660                 665                 670         


Val Asn Glu Lys Thr Ile Gly Ser Pro Pro Asn Glu Phe Tyr Cys Ser 
        675                 680                 685             


Glu Asn Thr Ser Val Pro Asn Glu Ser Asn Lys Ile Leu Val Asn Lys 
    690                 695                 700                 


Asp Val Pro Gln Lys Pro Gly Gly Glu Thr Thr Pro Ser Val Thr Asp 
705                 710                 715                 720 


Leu Leu Asn Tyr Phe Leu Ala Pro Glu Ile Leu Thr Gly Asp Asn Gln 
                725                 730                 735     


Tyr Tyr Cys Glu Asn Cys Ala Ser Leu Gln Asn Ala Glu Lys Thr Met 
            740                 745                 750         


Gln Ile Thr Glu Glu Pro Glu Tyr Leu Ile Leu Thr Leu Leu Arg Phe 
        755                 760                 765             


Ser Tyr Asp Gln Lys Tyr His Val Arg Arg Lys Ile Leu Asp Asn Val 
    770                 775                 780                 


Ser Leu Pro Leu Val Leu Glu Leu Pro Val Lys Arg Ile Thr Ser Phe 
785                 790                 795                 800 


Ser Ser Leu Ser Glu Ser Trp Ser Val Asp Val Asp Phe Thr Asp Leu 
                805                 810                 815     


Ser Glu Asn Leu Ala Lys Lys Leu Lys Pro Ser Gly Thr Asp Glu Ala 
            820                 825                 830         


Ser Cys Thr Lys Leu Val Pro Tyr Leu Leu Ser Ser Val Val Val His 
        835                 840                 845             


Ser Gly Ile Ser Ser Glu Ser Gly His Tyr Tyr Ser Tyr Ala Arg Asn 
    850                 855                 860                 


Ile Thr Ser Thr Asp Ser Ser Tyr Gln Met Tyr His Gln Ser Glu Ala 
865                 870                 875                 880 


Leu Ala Leu Ala Ser Ser Gln Ser His Leu Leu Gly Arg Asp Ser Pro 
                885                 890                 895     


Ser Ala Val Phe Glu Gln Asp Leu Glu Asn Lys Glu Met Ser Lys Glu 
            900                 905                 910         


Trp Phe Leu Phe Asn Asp Ser Arg Val Thr Phe Thr Ser Phe Gln Ser 
        915                 920                 925             


Val Gln Lys Ile Thr Ser Arg Phe Pro Lys Asp Thr Ala Tyr Val Leu 
    930                 935                 940                 


Leu Tyr Lys Lys Gln His Ser Thr Asn Gly Leu Ser Gly Asn Asn Pro 
945                 950                 955                 960 


Thr Ser Gly Leu Trp Ile Asn Gly Asp Pro Pro Leu Gln Lys Glu Leu 
                965                 970                 975     


Met Asp Ala Ile Thr Lys Asp Asn Lys Leu Tyr Leu Gln Glu Gln Glu 
            980                 985                 990         


Leu Asn Ala Arg Ala Arg Ala Leu  Gln Ala Ala Ser Ala  Ser Cys Ser 
        995                 1000                 1005             


Phe Arg  Pro Asn Gly Phe Asp  Asp Asn Asp Pro Pro  Gly Ser Cys 
    1010                 1015                 1020             


Gly Pro  Thr Gly Gly Gly Gly  Gly Gly Gly Phe Asn  Thr Val Gly 
    1025                 1030                 1035             


Arg Leu  Val Phe 
    1040         


<210> 13
<211> 1123
<212> PRT
<213> Homo sapiens

<400> 13
Met Asp Leu Gly Pro Gly Asp Ala Ala Gly Gly Gly Pro Leu Ala Pro 
1               5                   10                  15      


Arg Pro Arg Arg Arg Arg Ser Leu Arg Arg Leu Phe Ser Arg Phe Leu 
            20                  25                  30          


Leu Ala Leu Gly Ser Arg Ser Arg Pro Gly Asp Ser Pro Pro Arg Pro 
        35                  40                  45              


Gln Pro Gly His Cys Asp Gly Asp Gly Glu Gly Gly Phe Ala Cys Ala 
    50                  55                  60                  


Pro Gly Pro Val Pro Ala Ala Pro Gly Ser Pro Gly Glu Glu Arg Pro 
65                  70                  75                  80  


Pro Gly Pro Gln Pro Gln Leu Gln Leu Pro Ala Gly Asp Gly Ala Arg 
                85                  90                  95      


Pro Pro Gly Ala Gln Gly Leu Lys Asn His Gly Asn Thr Cys Phe Met 
            100                 105                 110         


Asn Ala Val Val Gln Cys Leu Ser Asn Thr Asp Leu Leu Ala Glu Phe 
        115                 120                 125             


Leu Ala Leu Gly Arg Tyr Arg Ala Ala Pro Gly Arg Ala Glu Val Thr 
    130                 135                 140                 


Glu Gln Leu Ala Ala Leu Val Arg Ala Leu Trp Thr Arg Glu Tyr Thr 
145                 150                 155                 160 


Pro Gln Leu Ser Ala Glu Phe Lys Asn Ala Val Ser Lys Tyr Gly Ser 
                165                 170                 175     


Gln Phe Gln Gly Asn Ser Gln His Asp Ala Leu Glu Phe Leu Leu Trp 
            180                 185                 190         


Leu Leu Asp Arg Val His Glu Asp Leu Glu Gly Ser Ser Arg Gly Pro 
        195                 200                 205             


Val Ser Glu Lys Leu Pro Pro Glu Ala Thr Lys Thr Ser Glu Asn Cys 
    210                 215                 220                 


Leu Ser Pro Ser Ala Gln Leu Pro Leu Gly Gln Ser Phe Val Gln Ser 
225                 230                 235                 240 


His Phe Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys Leu 
                245                 250                 255     


Lys Gln Ser Asn Thr Phe Asp Pro Phe Leu Cys Val Ser Leu Pro Ile 
            260                 265                 270         


Pro Leu Arg Gln Thr Arg Phe Leu Ser Val Thr Leu Val Phe Pro Ser 
        275                 280                 285             


Lys Ser Gln Arg Phe Leu Arg Val Gly Leu Ala Val Pro Ile Leu Ser 
    290                 295                 300                 


Thr Val Ala Ala Leu Arg Lys Met Val Ala Glu Glu Gly Gly Val Pro 
305                 310                 315                 320 


Ala Asp Glu Val Ile Leu Val Glu Leu Tyr Pro Ser Gly Phe Gln Arg 
                325                 330                 335     


Ser Phe Phe Asp Glu Glu Asp Leu Asn Thr Ile Ala Glu Gly Asp Asn 
            340                 345                 350         


Val Tyr Ala Phe Gln Val Pro Pro Ser Pro Ser Gln Gly Thr Leu Ser 
        355                 360                 365             


Ala His Pro Leu Gly Leu Ser Ala Ser Pro Arg Leu Ala Ala Arg Glu 
    370                 375                 380                 


Gly Gln Arg Phe Ser Leu Ser Leu His Ser Glu Ser Lys Val Leu Ile 
385                 390                 395                 400 


Leu Phe Cys Asn Leu Val Gly Ser Gly Gln Gln Ala Ser Arg Phe Gly 
                405                 410                 415     


Pro Pro Phe Leu Ile Arg Glu Asp Arg Ala Val Ser Trp Ala Gln Leu 
            420                 425                 430         


Gln Gln Ser Ile Leu Ser Lys Val Arg His Leu Met Lys Ser Glu Ala 
        435                 440                 445             


Pro Val Gln Asn Leu Gly Ser Leu Phe Ser Ile Arg Val Val Gly Leu 
    450                 455                 460                 


Ser Val Ala Cys Ser Tyr Leu Ser Pro Lys Asp Ser Arg Pro Leu Cys 
465                 470                 475                 480 


His Trp Ala Val Asp Arg Val Leu His Leu Arg Arg Pro Gly Gly Pro 
                485                 490                 495     


Pro His Val Lys Leu Ala Val Glu Trp Asp Ser Ser Val Lys Glu Arg 
            500                 505                 510         


Leu Phe Gly Ser Leu Gln Glu Glu Arg Ala Gln Asp Ala Asp Ser Val 
        515                 520                 525             


Trp Gln Gln Gln Gln Ala His Gln Gln His Ser Cys Thr Leu Asp Glu 
    530                 535                 540                 


Cys Phe Gln Phe Tyr Thr Lys Glu Glu Gln Leu Ala Gln Asp Asp Ala 
545                 550                 555                 560 


Trp Lys Cys Pro His Cys Gln Val Leu Gln Gln Gly Met Val Lys Leu 
                565                 570                 575     


Ser Leu Trp Thr Leu Pro Asp Ile Leu Ile Ile His Leu Lys Arg Phe 
            580                 585                 590         


Cys Gln Val Gly Glu Arg Arg Asn Lys Leu Ser Thr Leu Val Lys Phe 
        595                 600                 605             


Pro Leu Ser Gly Leu Asn Met Ala Pro His Val Ala Gln Arg Ser Thr 
    610                 615                 620                 


Ser Pro Glu Ala Gly Leu Gly Pro Trp Pro Ser Trp Lys Gln Pro Asp 
625                 630                 635                 640 


Cys Leu Pro Thr Ser Tyr Pro Leu Asp Phe Leu Tyr Asp Leu Tyr Ala 
                645                 650                 655     


Val Cys Asn His His Gly Asn Leu Gln Gly Gly His Tyr Thr Ala Tyr 
            660                 665                 670         


Cys Arg Asn Ser Leu Asp Gly Gln Trp Tyr Ser Tyr Asp Asp Ser Thr 
        675                 680                 685             


Val Glu Pro Leu Arg Glu Asp Glu Val Asn Thr Arg Gly Ala Tyr Ile 
    690                 695                 700                 


Leu Phe Tyr Gln Lys Arg Asn Ser Ile Pro Pro Trp Ser Ala Ser Ser 
705                 710                 715                 720 


Ser Met Arg Gly Ser Thr Ser Ser Ser Leu Ser Asp His Trp Leu Leu 
                725                 730                 735     


Arg Leu Gly Ser His Ala Gly Ser Thr Arg Gly Ser Leu Leu Ser Trp 
            740                 745                 750         


Ser Ser Ala Pro Cys Pro Ser Leu Pro Gln Val Pro Asp Ser Pro Ile 
        755                 760                 765             


Phe Thr Asn Ser Leu Cys Asn Gln Glu Lys Gly Gly Leu Glu Pro Arg 
    770                 775                 780                 


Arg Leu Val Arg Gly Val Lys Gly Arg Ser Ile Ser Met Lys Ala Pro 
785                 790                 795                 800 


Thr Thr Ser Arg Ala Lys Gln Gly Pro Phe Lys Thr Met Pro Leu Arg 
                805                 810                 815     


Trp Ser Phe Gly Ser Lys Glu Lys Pro Pro Gly Ala Ser Val Glu Leu 
            820                 825                 830         


Val Glu Tyr Leu Glu Ser Arg Arg Arg Pro Arg Ser Thr Ser Gln Ser 
        835                 840                 845             


Ile Val Ser Leu Leu Thr Gly Thr Ala Gly Glu Asp Glu Lys Ser Ala 
    850                 855                 860                 


Ser Pro Arg Ser Asn Val Ala Leu Pro Ala Asn Ser Glu Asp Gly Gly 
865                 870                 875                 880 


Arg Ala Ile Glu Arg Gly Pro Ala Gly Val Pro Cys Pro Ser Ala Gln 
                885                 890                 895     


Pro Asn His Cys Leu Ala Pro Gly Asn Ser Asp Gly Pro Asn Thr Ala 
            900                 905                 910         


Arg Lys Leu Lys Glu Asn Ala Gly Gln Asp Ile Lys Leu Pro Arg Lys 
        915                 920                 925             


Phe Asp Leu Pro Leu Thr Val Met Pro Ser Val Glu His Glu Lys Pro 
    930                 935                 940                 


Ala Arg Pro Glu Gly Gln Lys Ala Met Asn Trp Lys Glu Ser Phe Gln 
945                 950                 955                 960 


Met Gly Ser Lys Ser Ser Pro Pro Ser Pro Tyr Met Gly Phe Ser Gly 
                965                 970                 975     


Asn Ser Lys Asp Ser Arg Arg Gly Thr Ser Glu Leu Asp Arg Pro Leu 
            980                 985                 990         


Gln Gly Thr Leu Thr Leu Leu Arg  Ser Val Phe Arg Lys  Lys Glu Asn 
        995                 1000                 1005             


Arg Arg  Asn Glu Arg Ala Glu  Val Ser Pro Gln Val  Pro Pro Val 
    1010                 1015                 1020             


Ser Leu  Val Ser Gly Gly Leu  Ser Pro Ala Met Asp  Gly Gln Ala 
    1025                 1030                 1035             


Pro Gly  Ser Pro Pro Ala Leu  Arg Ile Pro Glu Gly  Leu Ala Arg 
    1040                 1045                 1050             


Gly Leu  Gly Ser Arg Leu Glu  Arg Asp Val Trp Ser  Ala Pro Ser 
    1055                 1060                 1065             


Ser Leu  Arg Leu Pro Arg Lys  Ala Ser Arg Ala Pro  Arg Gly Ser 
    1070                 1075                 1080             


Ala Leu  Gly Met Ser Gln Arg  Thr Val Pro Gly Glu  Gln Ala Ser 
    1085                 1090                 1095             


Tyr Gly  Thr Phe Gln Arg Val  Lys Tyr His Thr Leu  Ser Leu Gly 
    1100                 1105                 1110             


Arg Lys  Lys Thr Leu Pro Glu  Ser Ser Phe 
    1115                 1120             


<210> 14
<211> 605
<212> PRT
<213> Homo sapiens

<400> 14
Met Ser Gln Leu Ser Ser Thr Leu Lys Arg Tyr Thr Glu Ser Ala Arg 
1               5                   10                  15      


Tyr Thr Asp Ala His Tyr Ala Lys Ser Gly Tyr Gly Ala Tyr Thr Pro 
            20                  25                  30          


Ser Ser Tyr Gly Ala Asn Leu Ala Ala Ser Leu Leu Glu Lys Glu Lys 
        35                  40                  45              


Leu Gly Phe Lys Pro Val Pro Thr Ser Ser Phe Leu Thr Arg Pro Arg 
    50                  55                  60                  


Thr Tyr Gly Pro Ser Ser Leu Leu Asp Tyr Asp Arg Gly Arg Pro Leu 
65                  70                  75                  80  


Leu Arg Pro Asp Ile Thr Gly Gly Gly Lys Arg Ala Glu Ser Gln Thr 
                85                  90                  95      


Arg Gly Thr Glu Arg Pro Leu Gly Ser Gly Leu Ser Gly Gly Ser Gly 
            100                 105                 110         


Phe Pro Tyr Gly Val Thr Asn Asn Cys Leu Ser Tyr Leu Pro Ile Asn 
        115                 120                 125             


Ala Tyr Asp Gln Gly Val Thr Leu Thr Gln Lys Leu Asp Ser Gln Ser 
    130                 135                 140                 


Asp Leu Ala Arg Asp Phe Ser Ser Leu Arg Thr Ser Asp Ser Tyr Arg 
145                 150                 155                 160 


Ile Asp Pro Arg Asn Leu Gly Arg Ser Pro Met Leu Ala Arg Thr Arg 
                165                 170                 175     


Lys Glu Leu Cys Thr Leu Gln Gly Leu Tyr Gln Thr Ala Ser Cys Pro 
            180                 185                 190         


Glu Tyr Leu Val Asp Tyr Leu Glu Asn Tyr Gly Arg Lys Gly Ser Ala 
        195                 200                 205             


Ser Gln Val Pro Ser Gln Ala Pro Pro Ser Arg Val Pro Glu Ile Ile 
    210                 215                 220                 


Ser Pro Thr Tyr Arg Pro Ile Gly Arg Tyr Thr Leu Trp Glu Thr Gly 
225                 230                 235                 240 


Lys Gly Gln Ala Pro Gly Pro Ser Arg Ser Ser Ser Pro Gly Arg Asp 
                245                 250                 255     


Gly Met Asn Ser Lys Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu 
            260                 265                 270         


Gly Asn Thr Cys Phe Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr 
        275                 280                 285             


Arg Glu Leu Arg Asp Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu 
    290                 295                 300                 


His His Gly Ser Asn Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys 
305                 310                 315                 320 


Leu Ile Gln Thr Ile Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro 
                325                 330                 335     


Ser Glu Phe Lys Thr Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly 
            340                 345                 350         


Tyr Asn Gln Gln Asp Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly 
        355                 360                 365             


Leu His Asn Glu Val Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro 
    370                 375                 380                 


Glu Asn Leu Asp His Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp 
385                 390                 395                 400 


Arg Lys Tyr Leu Glu Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val 
                405                 410                 415     


Gly Gln Leu Lys Ser Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser 
            420                 425                 430         


Thr Val Phe Asp Pro Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg 
        435                 440                 445             


Gly Tyr Pro Glu Val Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys 
    450                 455                 460                 


Glu Asp Val Leu Asp Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg 
465                 470                 475                 480 


Gly Arg Lys Arg Cys Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys 
                485                 490                 495     


Ile Leu Val Leu His Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr 
            500                 505                 510         


Ser Lys Leu Thr Thr Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu 
        515                 520                 525             


Arg Glu Phe Ala Ser Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr 
    530                 535                 540                 


Ala Val Ser Asn His Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala 
545                 550                 555                 560 


Tyr Cys Arg Ser Pro Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser 
                565                 570                 575     


Ser Val Thr Pro Met Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr 
            580                 585                 590         


Leu Leu Phe Tyr Glu Leu Ala Ser Pro Pro Ser Arg Met 
        595                 600                 605 


<210> 15
<211> 814
<212> PRT
<213> Homo sapiens

<400> 15
Met Arg Val Lys Asp Pro Thr Lys Ala Leu Pro Glu Lys Ala Lys Arg 
1               5                   10                  15      


Ser Lys Arg Pro Thr Val Pro His Asp Glu Asp Ser Ser Asp Asp Ile 
            20                  25                  30          


Ala Val Gly Leu Thr Cys Gln His Val Ser His Ala Ile Ser Val Asn 
        35                  40                  45              


His Val Lys Arg Ala Ile Ala Glu Asn Leu Trp Ser Val Cys Ser Glu 
    50                  55                  60                  


Cys Leu Lys Glu Arg Arg Phe Tyr Asp Gly Gln Leu Val Leu Thr Ser 
65                  70                  75                  80  


Asp Ile Trp Leu Cys Leu Lys Cys Gly Phe Gln Gly Cys Gly Lys Asn 
                85                  90                  95      


Ser Glu Ser Gln His Ser Leu Lys His Phe Lys Ser Ser Arg Thr Glu 
            100                 105                 110         


Pro His Cys Ile Ile Ile Asn Leu Ser Thr Trp Ile Ile Trp Cys Tyr 
        115                 120                 125             


Glu Cys Asp Glu Lys Leu Ser Thr His Cys Asn Lys Lys Val Leu Ala 
    130                 135                 140                 


Gln Ile Val Asp Phe Leu Gln Lys His Ala Ser Lys Thr Gln Thr Ser 
145                 150                 155                 160 


Ala Phe Ser Arg Ile Met Lys Leu Cys Glu Glu Lys Cys Glu Thr Asp 
                165                 170                 175     


Glu Ile Gln Lys Gly Gly Lys Cys Arg Asn Leu Ser Val Arg Gly Ile 
            180                 185                 190         


Thr Asn Leu Gly Asn Thr Cys Phe Phe Asn Ala Val Met Gln Asn Leu 
        195                 200                 205             


Ala Gln Thr Tyr Thr Leu Thr Asp Leu Met Asn Glu Ile Lys Glu Ser 
    210                 215                 220                 


Ser Thr Lys Leu Lys Ile Phe Pro Ser Ser Asp Ser Gln Leu Asp Pro 
225                 230                 235                 240 


Leu Val Val Glu Leu Ser Arg Pro Gly Pro Leu Thr Ser Ala Leu Phe 
                245                 250                 255     


Leu Phe Leu His Ser Met Lys Glu Thr Glu Lys Gly Pro Leu Ser Pro 
            260                 265                 270         


Lys Val Leu Phe Asn Gln Leu Cys Gln Lys Ala Pro Arg Phe Lys Asp 
        275                 280                 285             


Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu His Tyr Leu Leu Asp Ala 
    290                 295                 300                 


Val Arg Thr Glu Glu Thr Lys Arg Ile Gln Ala Ser Ile Leu Lys Ala 
305                 310                 315                 320 


Phe Asn Asn Pro Thr Thr Lys Thr Ala Asp Asp Glu Thr Arg Lys Lys 
                325                 330                 335     


Val Lys Ala Tyr Gly Lys Glu Gly Val Lys Met Asn Phe Ile Asp Arg 
            340                 345                 350         


Ile Phe Ile Gly Glu Leu Thr Ser Thr Val Met Cys Glu Glu Cys Ala 
        355                 360                 365             


Asn Ile Ser Thr Val Lys Asp Pro Phe Ile Asp Ile Ser Leu Pro Ile 
    370                 375                 380                 


Ile Glu Glu Arg Val Ser Lys Pro Leu Leu Trp Gly Arg Met Asn Lys 
385                 390                 395                 400 


Tyr Arg Ser Leu Arg Glu Thr Asp His Asp Arg Tyr Ser Gly Asn Val 
                405                 410                 415     


Thr Ile Glu Asn Ile His Gln Pro Arg Ala Ala Lys Lys His Ser Ser 
            420                 425                 430         


Ser Lys Asp Lys Ser Gln Leu Ile His Asp Arg Lys Cys Ile Arg Lys 
        435                 440                 445             


Leu Ser Ser Gly Glu Thr Val Thr Tyr Gln Lys Asn Glu Asn Leu Glu 
    450                 455                 460                 


Met Asn Gly Asp Ser Leu Met Phe Ala Ser Leu Met Asn Ser Glu Ser 
465                 470                 475                 480 


Arg Leu Asn Glu Ser Pro Thr Asp Asp Ser Glu Lys Glu Ala Ser His 
                485                 490                 495     


Ser Glu Ser Asn Val Asp Ala Asp Ser Glu Pro Ser Glu Ser Glu Ser 
            500                 505                 510         


Ala Ser Lys Gln Thr Gly Leu Phe Arg Ser Ser Ser Gly Ser Gly Val 
        515                 520                 525             


Gln Pro Asp Gly Pro Leu Tyr Pro Leu Ser Ala Gly Lys Leu Leu Tyr 
    530                 535                 540                 


Thr Lys Glu Thr Asp Ser Gly Asp Lys Glu Met Ala Glu Ala Ile Ser 
545                 550                 555                 560 


Glu Leu Arg Leu Ser Ser Thr Val Thr Gly Asp Gln Asp Phe Asp Arg 
                565                 570                 575     


Glu Asn Gln Pro Leu Asn Ile Ser Asn Asn Leu Cys Phe Leu Glu Gly 
            580                 585                 590         


Lys His Leu Arg Ser Tyr Ser Pro Gln Asn Ala Phe Gln Thr Leu Ser 
        595                 600                 605             


Gln Ser Tyr Ile Thr Thr Ser Lys Glu Cys Ser Ile Gln Ser Cys Leu 
    610                 615                 620                 


Tyr Gln Phe Thr Ser Met Glu Leu Leu Met Gly Asn Asn Lys Leu Leu 
625                 630                 635                 640 


Cys Glu Asn Cys Thr Lys Asn Lys Gln Lys Tyr Gln Glu Glu Thr Ser 
                645                 650                 655     


Phe Ala Glu Lys Lys Val Glu Gly Val Tyr Thr Asn Ala Arg Lys Gln 
            660                 665                 670         


Leu Leu Ile Ser Ala Val Pro Ala Val Leu Ile Leu His Leu Lys Arg 
        675                 680                 685             


Phe His Gln Ala Gly Leu Ser Leu Arg Lys Val Asn Arg His Val Asp 
    690                 695                 700                 


Phe Pro Leu Met Leu Asp Leu Ala Pro Phe Cys Ser Ala Thr Cys Lys 
705                 710                 715                 720 


Asn Ala Ser Val Gly Asp Lys Val Leu Tyr Gly Leu Tyr Gly Ile Val 
                725                 730                 735     


Glu His Ser Gly Ser Met Arg Glu Gly His Tyr Thr Ala Tyr Val Lys 
            740                 745                 750         


Val Arg Thr Pro Ser Arg Lys Leu Ser Glu His Asn Thr Lys Lys Lys 
        755                 760                 765             


Asn Val Pro Gly Leu Lys Ala Ala Asp Asn Glu Ser Ala Gly Gln Trp 
    770                 775                 780                 


Val His Val Ser Asp Thr Tyr Leu Gln Val Val Pro Glu Ser Arg Ala 
785                 790                 795                 800 


Leu Ser Ala Gln Ala Tyr Leu Leu Phe Tyr Glu Arg Val Leu 
                805                 810                 


<210> 16
<211> 1604
<212> PRT
<213> Homo sapiens

<400> 16
Met Gly Ala Lys Glu Ser Arg Ile Gly Phe Leu Ser Tyr Glu Glu Ala 
1               5                   10                  15      


Leu Arg Arg Val Thr Asp Val Glu Leu Lys Arg Leu Lys Asp Ala Phe 
            20                  25                  30          


Lys Arg Thr Cys Gly Leu Ser Tyr Tyr Met Gly Gln His Cys Phe Ile 
        35                  40                  45              


Arg Glu Val Leu Gly Asp Gly Val Pro Pro Lys Val Ala Glu Val Ile 
    50                  55                  60                  


Tyr Cys Ser Phe Gly Gly Thr Ser Lys Gly Leu His Phe Asn Asn Leu 
65                  70                  75                  80  


Ile Val Gly Leu Val Leu Leu Thr Arg Gly Lys Asp Glu Glu Lys Ala 
                85                  90                  95      


Lys Tyr Ile Phe Ser Leu Phe Ser Ser Glu Ser Gly Asn Tyr Val Ile 
            100                 105                 110         


Arg Glu Glu Met Glu Arg Met Leu His Val Val Asp Gly Lys Val Pro 
        115                 120                 125             


Asp Thr Leu Arg Lys Cys Phe Ser Glu Gly Glu Lys Val Asn Tyr Glu 
    130                 135                 140                 


Lys Phe Arg Asn Trp Leu Phe Leu Asn Lys Asp Ala Phe Thr Phe Ser 
145                 150                 155                 160 


Arg Trp Leu Leu Ser Gly Gly Val Tyr Val Thr Leu Thr Asp Asp Ser 
                165                 170                 175     


Asp Thr Pro Thr Phe Tyr Gln Thr Leu Ala Gly Val Thr His Leu Glu 
            180                 185                 190         


Glu Ser Asp Ile Ile Asp Leu Glu Lys Arg Tyr Trp Leu Leu Lys Ala 
        195                 200                 205             


Gln Ser Arg Thr Gly Arg Phe Asp Leu Glu Thr Phe Gly Pro Leu Val 
    210                 215                 220                 


Ser Pro Pro Ile Arg Pro Ser Leu Ser Glu Gly Leu Phe Asn Ala Phe 
225                 230                 235                 240 


Asp Glu Asn Arg Asp Asn His Ile Asp Phe Lys Glu Ile Ser Cys Gly 
                245                 250                 255     


Leu Ser Ala Cys Cys Arg Gly Pro Leu Ala Glu Arg Gln Lys Phe Cys 
            260                 265                 270         


Phe Lys Val Phe Asp Val Asp Arg Asp Gly Val Leu Ser Arg Val Glu 
        275                 280                 285             


Leu Arg Asp Met Val Val Ala Leu Leu Glu Val Trp Lys Asp Asn Arg 
    290                 295                 300                 


Thr Asp Asp Ile Pro Glu Leu His Met Asp Leu Ser Asp Ile Val Glu 
305                 310                 315                 320 


Gly Ile Leu Asn Ala His Asp Thr Thr Lys Met Gly His Leu Thr Leu 
                325                 330                 335     


Glu Asp Tyr Gln Ile Trp Ser Val Lys Asn Val Leu Ala Asn Glu Phe 
            340                 345                 350         


Leu Asn Leu Leu Phe Gln Val Cys His Ile Val Leu Gly Leu Arg Pro 
        355                 360                 365             


Ala Thr Pro Glu Glu Glu Gly Gln Ile Ile Arg Gly Trp Leu Glu Arg 
    370                 375                 380                 


Glu Ser Arg Tyr Gly Leu Gln Ala Gly His Asn Trp Phe Ile Ile Ser 
385                 390                 395                 400 


Met Gln Trp Trp Gln Gln Trp Lys Glu Tyr Val Lys Tyr Asp Ala Asn 
                405                 410                 415     


Pro Val Val Ile Glu Pro Ser Ser Val Leu Asn Gly Gly Lys Tyr Ser 
            420                 425                 430         


Phe Gly Thr Ala Ala His Pro Met Glu Gln Val Glu Asp Arg Ile Gly 
        435                 440                 445             


Ser Ser Leu Ser Tyr Val Asn Thr Thr Glu Glu Lys Phe Ser Asp Asn 
    450                 455                 460                 


Ile Ser Thr Ala Ser Glu Ala Ser Glu Thr Ala Gly Ser Gly Phe Leu 
465                 470                 475                 480 


Tyr Ser Ala Thr Pro Gly Ala Asp Val Cys Phe Ala Arg Gln His Asn 
                485                 490                 495     


Thr Ser Asp Asn Asn Asn Gln Cys Leu Leu Gly Ala Asn Gly Asn Ile 
            500                 505                 510         


Leu Leu His Leu Asn Pro Gln Lys Pro Gly Ala Ile Asp Asn Gln Pro 
        515                 520                 525             


Leu Val Thr Gln Glu Pro Val Lys Ala Thr Ser Leu Thr Leu Glu Gly 
    530                 535                 540                 


Gly Arg Leu Lys Arg Thr Pro Gln Leu Ile His Gly Arg Asp Tyr Glu 
545                 550                 555                 560 


Met Val Pro Glu Pro Val Trp Arg Ala Leu Tyr His Trp Tyr Gly Ala 
                565                 570                 575     


Asn Leu Ala Leu Pro Arg Pro Val Ile Lys Asn Ser Lys Thr Asp Ile 
            580                 585                 590         


Pro Glu Leu Glu Leu Phe Pro Arg Tyr Leu Leu Phe Leu Arg Gln Gln 
        595                 600                 605             


Pro Ala Thr Arg Thr Gln Gln Ser Asn Ile Trp Val Asn Met Gly Asn 
    610                 615                 620                 


Val Pro Ser Pro Asn Ala Pro Leu Lys Arg Val Leu Ala Tyr Thr Gly 
625                 630                 635                 640 


Cys Phe Ser Arg Met Gln Thr Ile Lys Glu Ile His Glu Tyr Leu Ser 
                645                 650                 655     


Gln Arg Leu Arg Ile Lys Glu Glu Asp Met Arg Leu Trp Leu Tyr Asn 
            660                 665                 670         


Ser Glu Asn Tyr Leu Thr Leu Leu Asp Asp Glu Asp His Lys Leu Glu 
        675                 680                 685             


Tyr Leu Lys Ile Gln Asp Glu Gln His Leu Val Ile Glu Val Arg Asn 
    690                 695                 700                 


Lys Asp Met Ser Trp Pro Glu Glu Met Ser Phe Ile Ala Asn Ser Ser 
705                 710                 715                 720 


Lys Ile Asp Arg His Lys Val Pro Thr Glu Lys Gly Ala Thr Gly Leu 
                725                 730                 735     


Ser Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ser Ile Gln Cys Val 
            740                 745                 750         


Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe Ile Ser Gly Arg His Leu 
        755                 760                 765             


Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly Met Lys Gly His Met Ala 
    770                 775                 780                 


Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu Trp Ser Gly Thr Gln Lys 
785                 790                 795                 800 


Asn Val Ala Pro Leu Lys Leu Arg Trp Thr Ile Ala Lys Tyr Ala Pro 
                805                 810                 815     


Arg Phe Asn Gly Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe 
            820                 825                 830         


Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val His Glu Lys Pro 
        835                 840                 845             


Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg Pro Asp Trp Glu Val Ala 
    850                 855                 860                 


Ala Glu Ala Trp Asp Asn His Leu Arg Arg Asn Arg Ser Ile Val Val 
865                 870                 875                 880 


Asp Leu Phe His Gly Gln Leu Arg Ser Gln Val Lys Cys Lys Thr Cys 
                885                 890                 895     


Gly His Ile Ser Val Arg Phe Asp Pro Phe Asn Phe Leu Ser Leu Pro 
            900                 905                 910         


Leu Pro Met Asp Ser Tyr Met His Leu Glu Ile Thr Val Ile Lys Leu 
        915                 920                 925             


Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu Arg Leu Asn Met Asp Glu 
    930                 935                 940                 


Lys Tyr Thr Gly Leu Lys Lys Gln Leu Ser Asp Leu Cys Gly Leu Asn 
945                 950                 955                 960 


Ser Glu Gln Ile Leu Leu Ala Glu Val His Gly Ser Asn Ile Lys Asn 
                965                 970                 975     


Phe Pro Gln Asp Asn Gln Lys Val Arg Leu Ser Val Ser Gly Phe Leu 
            980                 985                 990         


Cys Ala Phe Glu Ile Pro Val Pro  Val Ser Pro Ile Ser  Ala Ser Ser 
        995                 1000                 1005             


Pro Thr  Gln Thr Asp Phe Ser  Ser Ser Pro Ser Thr  Asn Glu Met 
    1010                 1015                 1020             


Phe Thr  Leu Thr Thr Asn Gly  Asp Leu Pro Arg Pro  Ile Phe Ile 
    1025                 1030                 1035             


Pro Asn  Gly Met Pro Asn Thr  Val Val Pro Cys Gly  Thr Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Asn Gly Met Val  Asn Gly His Met Pro  Ser Leu Pro 
    1055                 1060                 1065             


Asp Ser  Pro Phe Thr Gly Tyr  Ile Ile Ala Val His  Arg Lys Met 
    1070                 1075                 1080             


Met Arg  Thr Glu Leu Tyr Phe  Leu Ser Ser Gln Lys  Asn Arg Pro 
    1085                 1090                 1095             


Ser Leu  Phe Gly Met Pro Leu  Ile Val Pro Cys Thr  Val His Thr 
    1100                 1105                 1110             


Arg Lys  Lys Asp Leu Tyr Asp  Ala Val Trp Ile Gln  Val Ser Arg 
    1115                 1120                 1125             


Leu Ala  Ser Pro Leu Pro Pro  Gln Glu Ala Ser Asn  His Ala Gln 
    1130                 1135                 1140             


Asp Cys  Asp Asp Ser Met Gly  Tyr Gln Tyr Pro Phe  Thr Leu Arg 
    1145                 1150                 1155             


Val Val  Gln Lys Asp Gly Asn  Ser Cys Ala Trp Cys  Pro Trp Tyr 
    1160                 1165                 1170             


Arg Phe  Cys Arg Gly Cys Lys  Ile Asp Cys Gly Glu  Asp Arg Ala 
    1175                 1180                 1185             


Phe Ile  Gly Asn Ala Tyr Ile  Ala Val Asp Trp Asp  Pro Thr Ala 
    1190                 1195                 1200             


Leu His  Leu Arg Tyr Gln Thr  Ser Gln Glu Arg Val  Val Asp Glu 
    1205                 1210                 1215             


His Glu  Ser Val Glu Gln Ser  Arg Arg Ala Gln Ala  Glu Pro Ile 
    1220                 1225                 1230             


Asn Leu  Asp Ser Cys Leu Arg  Ala Phe Thr Ser Glu  Glu Glu Leu 
    1235                 1240                 1245             


Gly Glu  Asn Glu Met Tyr Tyr  Cys Ser Lys Cys Lys  Thr His Cys 
    1250                 1255                 1260             


Leu Ala  Thr Lys Lys Leu Asp  Leu Trp Arg Leu Pro  Pro Ile Leu 
    1265                 1270                 1275             


Ile Ile  His Leu Lys Arg Phe  Gln Phe Val Asn Gly  Arg Trp Ile 
    1280                 1285                 1290             


Lys Ser  Gln Lys Ile Val Lys  Phe Pro Arg Glu Ser  Phe Asp Pro 
    1295                 1300                 1305             


Ser Ala  Phe Leu Val Pro Arg  Asp Pro Ala Leu Cys  Gln His Lys 
    1310                 1315                 1320             


Pro Leu  Thr Pro Gln Gly Asp  Glu Leu Ser Glu Pro  Arg Ile Leu 
    1325                 1330                 1335             


Ala Arg  Glu Val Lys Lys Val  Asp Ala Gln Ser Ser  Ala Gly Glu 
    1340                 1345                 1350             


Glu Asp  Val Leu Leu Ser Lys  Ser Pro Ser Ser Leu  Ser Ala Asn 
    1355                 1360                 1365             


Ile Ile  Ser Ser Pro Lys Gly  Ser Pro Ser Ser Ser  Arg Lys Ser 
    1370                 1375                 1380             


Gly Thr  Ser Cys Pro Ser Ser  Lys Asn Ser Ser Pro  Asn Ser Ser 
    1385                 1390                 1395             


Pro Arg  Thr Leu Gly Arg Ser  Lys Gly Arg Leu Arg  Leu Pro Gln 
    1400                 1405                 1410             


Ile Gly  Ser Lys Asn Lys Leu  Ser Ser Ser Lys Glu  Asn Leu Asp 
    1415                 1420                 1425             


Ala Ser  Lys Glu Asn Gly Ala  Gly Gln Ile Cys Glu  Leu Ala Asp 
    1430                 1435                 1440             


Ala Leu  Ser Arg Gly His Val  Leu Gly Gly Ser Gln  Pro Glu Leu 
    1445                 1450                 1455             


Val Thr  Pro Gln Asp His Glu  Val Ala Leu Ala Asn  Gly Phe Leu 
    1460                 1465                 1470             


Tyr Glu  His Glu Ala Cys Gly  Asn Gly Tyr Ser Asn  Gly Gln Leu 
    1475                 1480                 1485             


Gly Asn  His Ser Glu Glu Asp  Ser Thr Asp Asp Gln  Arg Glu Asp 
    1490                 1495                 1500             


Thr Arg  Ile Lys Pro Ile Tyr  Asn Leu Tyr Ala Ile  Ser Cys His 
    1505                 1510                 1515             


Ser Gly  Ile Leu Gly Gly Gly  His Tyr Val Thr Tyr  Ala Lys Asn 
    1520                 1525                 1530             


Pro Asn  Cys Lys Trp Tyr Cys  Tyr Asn Asp Ser Ser  Cys Lys Glu 
    1535                 1540                 1545             


Leu His  Pro Asp Glu Ile Asp  Thr Asp Ser Ala Tyr  Ile Leu Phe 
    1550                 1555                 1560             


Tyr Glu  Gln Gln Gly Ile Asp  Tyr Ala Gln Phe Leu  Pro Lys Thr 
    1565                 1570                 1575             


Asp Gly  Lys Lys Met Ala Asp  Thr Ser Ser Met Asp  Glu Asp Phe 
    1580                 1585                 1590             


Glu Ser  Asp Tyr Lys Lys Tyr  Cys Val Leu Gln 
    1595                 1600                 


<210> 17
<211> 398
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ser Glu Asp 
385                 390                 395             


<210> 18
<211> 1324
<212> PRT
<213> Homo sapiens

<400> 18
Met Thr Ile Val Asp Lys Ala Ser Glu Ser Ser Asp Pro Ser Ala Tyr 
1               5                   10                  15      


Gln Asn Gln Pro Gly Ser Ser Glu Ala Val Ser Pro Gly Asp Met Asp 
            20                  25                  30          


Ala Gly Ser Ala Ser Trp Gly Ala Val Ser Ser Leu Asn Asp Val Ser 
        35                  40                  45              


Asn His Thr Leu Ser Leu Gly Pro Val Pro Gly Ala Val Val Tyr Ser 
    50                  55                  60                  


Ser Ser Ser Val Pro Asp Lys Ser Lys Pro Ser Pro Gln Lys Asp Gln 
65                  70                  75                  80  


Ala Leu Gly Asp Gly Ile Ala Pro Pro Gln Lys Val Leu Phe Pro Ser 
                85                  90                  95      


Glu Lys Ile Cys Leu Lys Trp Gln Gln Thr His Arg Val Gly Ala Gly 
            100                 105                 110         


Leu Gln Asn Leu Gly Asn Thr Cys Phe Ala Asn Ala Ala Leu Gln Cys 
        115                 120                 125             


Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser His Glu His 
    130                 135                 140                 


Ser Lys Thr Cys His Ala Glu Gly Phe Cys Met Met Cys Thr Met Gln 
145                 150                 155                 160 


Ala His Ile Thr Gln Ala Leu Ser Asn Pro Gly Asp Val Ile Lys Pro 
                165                 170                 175     


Met Phe Val Ile Asn Glu Met Arg Arg Ile Ala Arg His Phe Arg Phe 
            180                 185                 190         


Gly Asn Gln Glu Asp Ala His Glu Phe Leu Gln Tyr Thr Val Asp Ala 
        195                 200                 205             


Met Gln Lys Ala Cys Leu Asn Gly Ser Asn Lys Leu Asp Arg His Thr 
    210                 215                 220                 


Gln Ala Thr Thr Leu Val Cys Gln Ile Phe Gly Gly Tyr Leu Arg Ser 
225                 230                 235                 240 


Arg Val Lys Cys Leu Asn Cys Lys Gly Val Ser Asp Thr Phe Asp Pro 
                245                 250                 255     


Tyr Leu Asp Ile Thr Leu Glu Ile Lys Ala Ala Gln Ser Val Asn Lys 
            260                 265                 270         


Ala Leu Glu Gln Phe Val Lys Pro Glu Gln Leu Asp Gly Glu Asn Ser 
        275                 280                 285             


Tyr Lys Cys Ser Lys Cys Lys Lys Met Val Pro Ala Ser Lys Arg Phe 
    290                 295                 300                 


Thr Ile His Arg Ser Ser Asn Val Leu Thr Leu Ser Leu Lys Arg Phe 
305                 310                 315                 320 


Ala Asn Phe Thr Gly Gly Lys Ile Ala Lys Asp Val Lys Tyr Pro Glu 
                325                 330                 335     


Tyr Leu Asp Ile Arg Pro Tyr Met Ser Gln Pro Asn Gly Glu Pro Ile 
            340                 345                 350         


Val Tyr Val Leu Tyr Ala Val Leu Val His Thr Gly Phe Asn Cys His 
        355                 360                 365             


Ala Gly His Tyr Phe Cys Tyr Ile Lys Ala Ser Asn Gly Leu Trp Tyr 
    370                 375                 380                 


Gln Met Asn Asp Ser Ile Val Ser Thr Ser Asp Ile Arg Ser Val Leu 
385                 390                 395                 400 


Ser Gln Gln Ala Tyr Val Leu Phe Tyr Ile Arg Ser His Asp Val Lys 
                405                 410                 415     


Asn Gly Gly Glu Leu Thr His Pro Thr His Ser Pro Gly Gln Ser Ser 
            420                 425                 430         


Pro Arg Pro Val Ile Ser Gln Arg Val Val Thr Asn Lys Gln Ala Ala 
        435                 440                 445             


Pro Gly Phe Ile Gly Pro Gln Leu Pro Ser His Met Ile Lys Asn Pro 
    450                 455                 460                 


Pro His Leu Asn Gly Thr Gly Pro Leu Lys Asp Thr Pro Ser Ser Ser 
465                 470                 475                 480 


Met Ser Ser Pro Asn Gly Asn Ser Ser Val Asn Arg Ala Ser Pro Val 
                485                 490                 495     


Asn Ala Ser Ala Ser Val Gln Asn Trp Ser Val Asn Arg Ser Ser Val 
            500                 505                 510         


Ile Pro Glu His Pro Lys Lys Gln Lys Ile Thr Ile Ser Ile His Asn 
        515                 520                 525             


Lys Leu Pro Val Arg Gln Cys Gln Ser Gln Pro Asn Leu His Ser Asn 
    530                 535                 540                 


Ser Leu Glu Asn Pro Thr Lys Pro Val Pro Ser Ser Thr Ile Thr Asn 
545                 550                 555                 560 


Ser Ala Val Gln Ser Thr Ser Asn Ala Ser Thr Met Ser Val Ser Ser 
                565                 570                 575     


Lys Val Thr Lys Pro Ile Pro Arg Ser Glu Ser Cys Ser Gln Pro Val 
            580                 585                 590         


Met Asn Gly Lys Ser Lys Leu Asn Ser Ser Val Leu Val Pro Tyr Gly 
        595                 600                 605             


Ala Glu Ser Ser Glu Asp Ser Asp Glu Glu Ser Lys Gly Leu Gly Lys 
    610                 615                 620                 


Glu Asn Gly Ile Gly Thr Ile Val Ser Ser His Ser Pro Gly Gln Asp 
625                 630                 635                 640 


Ala Glu Asp Glu Glu Ala Thr Pro His Glu Leu Gln Glu Pro Met Thr 
                645                 650                 655     


Leu Asn Gly Ala Asn Ser Ala Asp Ser Asp Ser Asp Pro Lys Glu Asn 
            660                 665                 670         


Gly Leu Ala Pro Asp Gly Ala Ser Cys Gln Gly Gln Pro Ala Leu His 
        675                 680                 685             


Ser Glu Asn Pro Phe Ala Lys Ala Asn Gly Leu Pro Gly Lys Leu Met 
    690                 695                 700                 


Pro Ala Pro Leu Leu Ser Leu Pro Glu Asp Lys Ile Leu Glu Thr Phe 
705                 710                 715                 720 


Arg Leu Ser Asn Lys Leu Lys Gly Ser Thr Asp Glu Met Ser Ala Pro 
                725                 730                 735     


Gly Ala Glu Arg Gly Pro Pro Glu Asp Arg Asp Ala Glu Pro Gln Pro 
            740                 745                 750         


Gly Ser Pro Ala Ala Glu Ser Leu Glu Glu Pro Asp Ala Ala Ala Gly 
        755                 760                 765             


Leu Ser Ser Thr Lys Lys Ala Pro Pro Pro Arg Asp Pro Gly Thr Pro 
    770                 775                 780                 


Ala Thr Lys Glu Gly Ala Trp Glu Ala Met Ala Val Ala Pro Glu Glu 
785                 790                 795                 800 


Pro Pro Pro Ser Ala Gly Glu Asp Ile Val Gly Asp Thr Ala Pro Pro 
                805                 810                 815     


Asp Leu Cys Asp Pro Gly Ser Leu Thr Gly Asp Ala Ser Pro Leu Ser 
            820                 825                 830         


Gln Asp Ala Lys Gly Met Ile Ala Glu Gly Pro Arg Asp Ser Ala Leu 
        835                 840                 845             


Ala Glu Ala Pro Glu Gly Leu Ser Pro Ala Pro Pro Ala Arg Ser Glu 
    850                 855                 860                 


Glu Pro Cys Glu Gln Pro Leu Leu Val His Pro Ser Gly Asp His Ala 
865                 870                 875                 880 


Arg Asp Ala Gln Asp Pro Ser Gln Ser Leu Gly Ala Pro Glu Ala Ala 
                885                 890                 895     


Glu Arg Pro Pro Ala Pro Val Leu Asp Met Ala Pro Ala Gly His Pro 
            900                 905                 910         


Glu Gly Asp Ala Glu Pro Ser Pro Gly Glu Arg Val Glu Asp Ala Ala 
        915                 920                 925             


Ala Pro Lys Ala Pro Gly Pro Ser Pro Ala Lys Glu Lys Ile Gly Ser 
    930                 935                 940                 


Leu Arg Lys Val Asp Arg Gly His Tyr Arg Ser Arg Arg Glu Arg Ser 
945                 950                 955                 960 


Ser Ser Gly Glu Pro Ala Arg Glu Ser Arg Ser Lys Thr Glu Gly His 
                965                 970                 975     


Arg His Arg Arg Arg Arg Thr Cys Pro Arg Glu Arg Asp Arg Gln Asp 
            980                 985                 990         


Arg His Ala Pro Glu His His Pro  Gly His Gly Asp Arg  Leu Ser Pro 
        995                 1000                 1005             


Gly Glu  Arg Arg Ser Leu Gly  Arg Cys Ser His His  His Ser Arg 
    1010                 1015                 1020             


His Arg  Ser Gly Val Glu Leu  Asp Trp Val Arg His  His Tyr Thr 
    1025                 1030                 1035             


Glu Gly  Glu Arg Gly Trp Gly  Arg Glu Lys Phe Tyr  Pro Asp Arg 
    1040                 1045                 1050             


Pro Arg  Trp Asp Arg Cys Arg  Tyr Tyr His Asp Arg  Tyr Ala Leu 
    1055                 1060                 1065             


Tyr Ala  Ala Arg Asp Trp Lys  Pro Phe His Gly Gly  Arg Glu His 
    1070                 1075                 1080             


Glu Arg  Ala Gly Leu His Glu  Arg Pro His Lys Asp  His Asn Arg 
    1085                 1090                 1095             


Gly Arg  Arg Gly Cys Glu Pro  Ala Arg Glu Arg Glu  Arg His Arg 
    1100                 1105                 1110             


Pro Ser  Ser Pro Arg Ala Gly  Ala Pro His Ala Leu  Ala Pro His 
    1115                 1120                 1125             


Pro Asp  Arg Phe Ser His Asp  Arg Thr Ala Leu Val  Ala Gly Asp 
    1130                 1135                 1140             


Asn Cys  Asn Leu Ser Asp Arg  Phe His Glu His Glu  Asn Gly Lys 
    1145                 1150                 1155             


Ser Arg  Lys Arg Arg His Asp  Ser Val Glu Asn Ser  Asp Ser His 
    1160                 1165                 1170             


Val Glu  Lys Lys Ala Arg Arg  Ser Glu Gln Lys Asp  Pro Leu Glu 
    1175                 1180                 1185             


Glu Pro  Lys Ala Lys Lys His  Lys Lys Ser Lys Lys  Lys Lys Lys 
    1190                 1195                 1200             


Ser Lys  Asp Lys His Arg Asp  Arg Asp Ser Arg His  Gln Gln Asp 
    1205                 1210                 1215             


Ser Asp  Leu Ser Ala Ala Cys  Ser Asp Ala Asp Leu  His Arg His 
    1220                 1225                 1230             


Lys Lys  Lys Lys Lys Lys Lys  Lys Arg His Ser Arg  Lys Ser Glu 
    1235                 1240                 1245             


Asp Phe  Val Lys Asp Ser Glu  Leu His Leu Pro Arg  Val Thr Ser 
    1250                 1255                 1260             


Leu Glu  Thr Val Ala Gln Phe  Arg Arg Ala Gln Gly  Gly Phe Pro 
    1265                 1270                 1275             


Leu Ser  Gly Gly Pro Pro Leu  Glu Gly Val Gly Pro  Phe Arg Glu 
    1280                 1285                 1290             


Lys Thr  Lys His Leu Arg Met  Glu Ser Arg Asp Asp  Arg Cys Arg 
    1295                 1300                 1305             


Leu Phe  Glu Tyr Gly Gln Gly  Lys Arg Arg Tyr Leu  Glu Leu Gly 
    1310                 1315                 1320             


Arg 
    


<210> 19
<211> 530
<212> PRT
<213> Homo sapiens

<400> 19
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Asp Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Leu Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Ser Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Phe Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Lys Ile Gly Asn Thr Phe Tyr Val Asn Val Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ser Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


Asp Ser Gln Thr Cys His Leu His Lys Cys Cys Met Phe Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Val Leu Ala Ala Gly Phe His Arg Gly Glu Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Leu Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Ala Tyr Trp Arg Ser Gln Ile Lys Tyr Leu 
        195                 200                 205             


His Cys His Gly Val Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Lys Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Lys Ala Pro Ala Ser Lys Thr Leu Thr Leu Pro Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Lys Cys Arg Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Gly Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Lys Pro Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Ser Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Asn Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 20
<211> 530
<212> PRT
<213> Homo sapiens

<400> 20
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 21
<211> 863
<212> PRT
<213> Homo sapiens

<400> 21
Met Gln Arg Arg Gly Ala Leu Phe Gly Met Pro Gly Gly Ser Gly Gly 
1               5                   10                  15      


Arg Lys Met Ala Ala Gly Asp Ile Gly Glu Leu Leu Val Pro His Met 
            20                  25                  30          


Pro Thr Ile Arg Val Pro Arg Ser Gly Asp Arg Val Tyr Lys Asn Glu 
        35                  40                  45              


Cys Ala Phe Ser Tyr Asp Ser Pro Asn Ser Glu Gly Gly Leu Tyr Val 
    50                  55                  60                  


Cys Met Asn Thr Phe Leu Ala Phe Gly Arg Glu His Val Glu Arg His 
65                  70                  75                  80  


Phe Arg Lys Thr Gly Gln Ser Val Tyr Met His Leu Lys Arg His Val 
                85                  90                  95      


Arg Glu Lys Val Arg Gly Ala Ser Gly Gly Ala Leu Pro Lys Arg Arg 
            100                 105                 110         


Asn Ser Lys Ile Phe Leu Asp Leu Asp Thr Asp Asp Asp Leu Asn Ser 
        115                 120                 125             


Asp Asp Tyr Glu Tyr Glu Asp Glu Ala Lys Leu Val Ile Phe Pro Asp 
    130                 135                 140                 


His Tyr Glu Ile Ala Leu Pro Asn Ile Glu Glu Leu Pro Ala Leu Val 
145                 150                 155                 160 


Thr Ile Ala Cys Asp Ala Val Leu Ser Ser Lys Ser Pro Tyr Arg Lys 
                165                 170                 175     


Gln Asp Pro Asp Thr Trp Glu Asn Glu Leu Pro Val Ser Lys Tyr Ala 
            180                 185                 190         


Asn Asn Leu Thr Gln Leu Asp Asn Gly Val Arg Ile Pro Pro Ser Gly 
        195                 200                 205             


Trp Lys Cys Ala Arg Cys Asp Leu Arg Glu Asn Leu Trp Leu Asn Leu 
    210                 215                 220                 


Thr Asp Gly Ser Val Leu Cys Gly Lys Trp Phe Phe Asp Ser Ser Gly 
225                 230                 235                 240 


Gly Asn Gly His Ala Leu Glu His Tyr Arg Asp Met Gly Tyr Pro Leu 
                245                 250                 255     


Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala Asp Val Tyr Ser 
            260                 265                 270         


Phe Gln Glu Glu Glu Pro Val Leu Asp Pro His Leu Ala Lys His Leu 
        275                 280                 285             


Ala His Phe Gly Ile Asp Met Leu His Met His Gly Thr Glu Asn Gly 
    290                 295                 300                 


Leu Gln Asp Asn Asp Ile Lys Leu Arg Val Ser Glu Trp Glu Val Ile 
305                 310                 315                 320 


Gln Glu Ser Gly Thr Lys Leu Lys Pro Met Tyr Gly Pro Gly Tyr Thr 
                325                 330                 335     


Gly Leu Lys Asn Leu Gly Asn Ser Cys Tyr Leu Ser Ser Val Met Gln 
            340                 345                 350         


Ala Ile Phe Ser Ile Pro Glu Phe Gln Arg Ala Tyr Val Gly Asn Leu 
        355                 360                 365             


Pro Arg Ile Phe Asp Tyr Ser Pro Leu Asp Pro Thr Gln Asp Phe Asn 
    370                 375                 380                 


Thr Gln Met Thr Lys Leu Gly His Gly Leu Leu Ser Gly Gln Tyr Ser 
385                 390                 395                 400 


Lys Pro Pro Val Lys Ser Glu Leu Ile Glu Gln Val Met Lys Glu Glu 
                405                 410                 415     


His Lys Pro Gln Gln Asn Gly Ile Ser Pro Arg Met Phe Lys Ala Phe 
            420                 425                 430         


Val Ser Lys Ser His Pro Glu Phe Ser Ser Asn Arg Gln Gln Asp Ala 
        435                 440                 445             


Gln Glu Phe Phe Leu His Leu Val Asn Leu Val Glu Arg Asn Arg Ile 
    450                 455                 460                 


Gly Ser Glu Asn Pro Ser Asp Val Phe Arg Phe Leu Val Glu Glu Arg 
465                 470                 475                 480 


Ile Gln Cys Cys Gln Thr Arg Lys Val Arg Tyr Thr Glu Arg Val Asp 
                485                 490                 495     


Tyr Leu Met Gln Leu Pro Val Ala Met Glu Ala Ala Thr Asn Lys Asp 
            500                 505                 510         


Glu Leu Ile Ala Tyr Glu Leu Thr Arg Arg Glu Ala Glu Ala Asn Arg 
        515                 520                 525             


Arg Pro Leu Pro Glu Leu Val Arg Ala Lys Ile Pro Phe Ser Ala Cys 
    530                 535                 540                 


Leu Gln Ala Phe Ser Glu Pro Glu Asn Val Asp Asp Phe Trp Ser Ser 
545                 550                 555                 560 


Ala Leu Gln Ala Lys Ser Ala Gly Val Lys Thr Ser Arg Phe Ala Ser 
                565                 570                 575     


Phe Pro Glu Tyr Leu Val Val Gln Ile Lys Lys Phe Thr Phe Gly Leu 
            580                 585                 590         


Asp Trp Val Pro Lys Lys Phe Asp Val Ser Ile Asp Met Pro Asp Leu 
        595                 600                 605             


Leu Asp Ile Asn His Leu Arg Ala Arg Gly Leu Gln Pro Gly Glu Glu 
    610                 615                 620                 


Glu Leu Pro Asp Ile Ser Pro Pro Ile Val Ile Pro Asp Asp Ser Lys 
625                 630                 635                 640 


Asp Arg Leu Met Asn Gln Leu Ile Asp Pro Ser Asp Ile Asp Glu Ser 
                645                 650                 655     


Ser Val Met Gln Leu Ala Glu Met Gly Phe Pro Leu Glu Ala Cys Arg 
            660                 665                 670         


Lys Ala Val Tyr Phe Thr Gly Asn Met Gly Ala Glu Val Ala Phe Asn 
        675                 680                 685             


Trp Ile Ile Val His Met Glu Glu Pro Asp Phe Ala Glu Pro Leu Thr 
    690                 695                 700                 


Met Pro Gly Tyr Gly Gly Ala Ala Ser Ala Gly Ala Ser Val Phe Gly 
705                 710                 715                 720 


Ala Ser Gly Leu Asp Asn Gln Pro Pro Glu Glu Ile Val Ala Ile Ile 
                725                 730                 735     


Thr Ser Met Gly Phe Gln Arg Asn Gln Ala Ile Gln Ala Leu Arg Ala 
            740                 745                 750         


Thr Asn Asn Asn Leu Glu Arg Ala Leu Asp Trp Ile Phe Ser His Pro 
        755                 760                 765             


Glu Phe Glu Glu Asp Ser Asp Phe Val Ile Glu Met Glu Asn Asn Ala 
    770                 775                 780                 


Asn Ala Asn Ile Ile Ser Glu Ala Lys Pro Glu Gly Pro Arg Val Lys 
785                 790                 795                 800 


Asp Gly Ser Gly Thr Tyr Glu Leu Phe Ala Phe Ile Ser His Met Gly 
                805                 810                 815     


Thr Ser Thr Met Ser Gly His Tyr Ile Cys His Ile Lys Lys Glu Gly 
            820                 825                 830         


Arg Trp Val Ile Tyr Asn Asp His Lys Val Cys Ala Ser Glu Arg Pro 
        835                 840                 845             


Pro Lys Asp Leu Gly Tyr Met Tyr Phe Tyr Arg Arg Ile Pro Ser 
    850                 855                 860             


<210> 22
<211> 963
<212> PRT
<213> Homo sapiens

<400> 22
Met Ala Val Ala Pro Arg Leu Phe Gly Gly Leu Cys Phe Arg Phe Arg 
1               5                   10                  15      


Asp Gln Asn Pro Glu Val Ala Val Glu Gly Arg Leu Pro Ile Ser His 
            20                  25                  30          


Ser Cys Val Gly Cys Arg Arg Glu Arg Thr Ala Met Ala Thr Val Ala 
        35                  40                  45              


Ala Asn Pro Ala Ala Ala Ala Ala Ala Val Ala Ala Ala Ala Ala Val 
    50                  55                  60                  


Thr Glu Asp Arg Glu Pro Gln His Glu Glu Leu Pro Gly Leu Asp Ser 
65                  70                  75                  80  


Gln Trp Arg Gln Ile Glu Asn Gly Glu Ser Gly Arg Glu Arg Pro Leu 
                85                  90                  95      


Arg Ala Gly Glu Ser Trp Phe Leu Val Glu Lys His Trp Tyr Lys Gln 
            100                 105                 110         


Trp Glu Ala Tyr Val Gln Gly Gly Asp Gln Asp Ser Ser Thr Phe Pro 
        115                 120                 125             


Gly Cys Ile Asn Asn Ala Thr Leu Phe Gln Asp Glu Ile Asn Trp Arg 
    130                 135                 140                 


Leu Lys Glu Gly Leu Val Glu Gly Glu Asp Tyr Val Leu Leu Pro Ala 
145                 150                 155                 160 


Ala Ala Trp His Tyr Leu Val Ser Trp Tyr Gly Leu Glu His Gly Gln 
                165                 170                 175     


Pro Pro Ile Glu Arg Lys Val Ile Glu Leu Pro Asn Ile Gln Lys Val 
            180                 185                 190         


Glu Val Tyr Pro Val Glu Leu Leu Leu Val Arg His Asn Asp Leu Gly 
        195                 200                 205             


Lys Ser His Thr Val Gln Phe Ser His Thr Asp Ser Ile Gly Leu Val 
    210                 215                 220                 


Leu Arg Thr Ala Arg Glu Arg Phe Leu Val Glu Pro Gln Glu Asp Thr 
225                 230                 235                 240 


Arg Leu Trp Ala Lys Asn Ser Glu Gly Ser Leu Asp Arg Leu Tyr Asp 
                245                 250                 255     


Thr His Ile Thr Val Leu Asp Ala Ala Leu Glu Thr Gly Gln Leu Ile 
            260                 265                 270         


Ile Met Glu Thr Arg Lys Lys Asp Gly Thr Trp Pro Ser Ala Gln Leu 
        275                 280                 285             


His Val Met Asn Asn Asn Met Ser Glu Glu Asp Glu Asp Phe Lys Gly 
    290                 295                 300                 


Gln Pro Gly Ile Cys Gly Leu Thr Asn Leu Gly Asn Thr Cys Phe Met 
305                 310                 315                 320 


Asn Ser Ala Leu Gln Cys Leu Ser Asn Val Pro Gln Leu Thr Glu Tyr 
                325                 330                 335     


Phe Leu Asn Asn Cys Tyr Leu Glu Glu Leu Asn Phe Arg Asn Pro Leu 
            340                 345                 350         


Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Asp Leu Val Lys Gln 
        355                 360                 365             


Ala Trp Ser Gly His His Arg Ser Ile Val Pro His Val Phe Lys Asn 
    370                 375                 380                 


Lys Val Gly His Phe Ala Ser Gln Phe Leu Gly Tyr Gln Gln His Asp 
385                 390                 395                 400 


Ser Gln Glu Leu Leu Ser Phe Leu Leu Asp Gly Leu His Glu Asp Leu 
                405                 410                 415     


Asn Arg Val Lys Lys Lys Glu Tyr Val Glu Leu Cys Asp Ala Ala Gly 
            420                 425                 430         


Arg Pro Asp Gln Glu Val Ala Gln Glu Ala Trp Gln Asn His Lys Arg 
        435                 440                 445             


Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu Phe Lys Ser 
    450                 455                 460                 


Thr Leu Val Cys Pro Asp Cys Gly Asn Val Ser Val Thr Phe Asp Pro 
465                 470                 475                 480 


Phe Cys Tyr Leu Ser Val Pro Leu Pro Ile Ser His Lys Arg Val Leu 
                485                 490                 495     


Glu Val Phe Phe Ile Pro Met Asp Pro Arg Arg Lys Pro Glu Gln His 
            500                 505                 510         


Arg Leu Val Val Pro Lys Lys Gly Lys Ile Ser Asp Leu Cys Val Ala 
        515                 520                 525             


Leu Ser Lys His Thr Gly Ile Ser Pro Glu Arg Met Met Val Ala Asp 
    530                 535                 540                 


Val Phe Ser His Arg Phe Tyr Lys Leu Tyr Gln Leu Glu Glu Pro Leu 
545                 550                 555                 560 


Ser Ser Ile Leu Asp Arg Asp Asp Ile Phe Val Tyr Glu Val Ser Gly 
                565                 570                 575     


Arg Ile Glu Ala Ile Glu Gly Ser Arg Glu Asp Ile Val Val Pro Val 
            580                 585                 590         


Tyr Leu Arg Glu Arg Thr Pro Ala Arg Asp Tyr Asn Asn Ser Tyr Tyr 
        595                 600                 605             


Gly Leu Met Leu Phe Gly His Pro Leu Leu Val Ser Val Pro Arg Asp 
    610                 615                 620                 


Arg Phe Thr Trp Glu Gly Leu Tyr Asn Val Leu Met Tyr Arg Leu Ser 
625                 630                 635                 640 


Arg Tyr Val Thr Lys Pro Asn Ser Asp Asp Glu Asp Asp Gly Asp Glu 
                645                 650                 655     


Lys Glu Asp Asp Glu Glu Asp Lys Asp Asp Val Pro Gly Pro Ser Thr 
            660                 665                 670         


Gly Gly Ser Leu Arg Asp Pro Glu Pro Glu Gln Ala Gly Pro Ser Ser 
        675                 680                 685             


Gly Val Thr Asn Arg Cys Pro Phe Leu Leu Asp Asn Cys Leu Gly Thr 
    690                 695                 700                 


Ser Gln Trp Pro Pro Arg Arg Arg Arg Lys Gln Leu Phe Thr Leu Gln 
705                 710                 715                 720 


Thr Val Asn Ser Asn Gly Thr Ser Asp Arg Thr Thr Ser Pro Glu Glu 
                725                 730                 735     


Val His Ala Gln Pro Tyr Ile Ala Ile Asp Trp Glu Pro Glu Met Lys 
            740                 745                 750         


Lys Arg Tyr Tyr Asp Glu Val Glu Ala Glu Gly Tyr Val Lys His Asp 
        755                 760                 765             


Cys Val Gly Tyr Val Met Lys Lys Ala Pro Val Arg Leu Gln Glu Cys 
    770                 775                 780                 


Ile Glu Leu Phe Thr Thr Val Glu Thr Leu Glu Lys Glu Asn Pro Trp 
785                 790                 795                 800 


Tyr Cys Pro Ser Cys Lys Gln His Gln Leu Ala Thr Lys Lys Leu Asp 
                805                 810                 815     


Leu Trp Met Leu Pro Glu Ile Leu Ile Ile His Leu Lys Arg Phe Ser 
            820                 825                 830         


Tyr Thr Lys Phe Ser Arg Glu Lys Leu Asp Thr Leu Val Glu Phe Pro 
        835                 840                 845             


Ile Arg Asp Leu Asp Phe Ser Glu Phe Val Ile Gln Pro Gln Asn Glu 
    850                 855                 860                 


Ser Asn Pro Glu Leu Tyr Lys Tyr Asp Leu Ile Ala Val Ser Asn His 
865                 870                 875                 880 


Tyr Gly Gly Met Arg Asp Gly His Tyr Thr Thr Phe Ala Cys Asn Lys 
                885                 890                 895     


Asp Ser Gly Gln Trp His Tyr Phe Asp Asp Asn Ser Val Ser Pro Val 
            900                 905                 910         


Asn Glu Asn Gln Ile Glu Ser Lys Ala Ala Tyr Val Leu Phe Tyr Gln 
        915                 920                 925             


Arg Gln Asp Val Ala Arg Arg Leu Leu Ser Pro Ala Gly Ser Ser Gly 
    930                 935                 940                 


Ala Pro Ala Ser Pro Ala Cys Ser Ser Pro Pro Ser Ser Glu Phe Met 
945                 950                 955                 960 


Asp Val Asn 
            


<210> 23
<211> 530
<212> PRT
<213> Homo sapiens

<400> 23
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Cys Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Val Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Ile Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Gly Lys Val Glu Gly Thr Leu Pro Pro Asn Ala Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ala Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 24
<211> 494
<212> PRT
<213> Homo sapiens

<400> 24
Met Pro Leu Tyr Ser Val Thr Val Lys Trp Gly Lys Glu Lys Phe Glu 
1               5                   10                  15      


Gly Val Glu Leu Asn Thr Asp Glu Pro Pro Met Val Phe Lys Ala Gln 
            20                  25                  30          


Leu Phe Ala Leu Thr Gly Val Gln Pro Ala Arg Gln Lys Val Met Val 
        35                  40                  45              


Lys Gly Gly Thr Leu Lys Asp Asp Asp Trp Gly Asn Ile Lys Ile Lys 
    50                  55                  60                  


Asn Gly Met Thr Leu Leu Met Met Gly Ser Ala Asp Ala Leu Pro Glu 
65                  70                  75                  80  


Glu Pro Ser Ala Lys Thr Val Phe Val Glu Asp Met Thr Glu Glu Gln 
                85                  90                  95      


Leu Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn 
            100                 105                 110         


Thr Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu 
        115                 120                 125             


Leu Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly 
    130                 135                 140                 


Glu Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe 
145                 150                 155                 160 


Asp Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu 
                165                 170                 175     


Gln Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln 
            180                 185                 190         


Gly Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met 
        195                 200                 205             


Arg Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys 
    210                 215                 220                 


Glu Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys 
225                 230                 235                 240 


Ser Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys 
                245                 250                 255     


Cys Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln 
            260                 265                 270         


Leu Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr 
        275                 280                 285             


Gly Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr 
    290                 295                 300                 


Leu Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu 
305                 310                 315                 320 


Pro Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys 
                325                 330                 335     


Glu Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met 
            340                 345                 350         


Leu Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val 
        355                 360                 365             


Ser Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln 
    370                 375                 380                 


Gln Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys 
385                 390                 395                 400 


Tyr Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly 
                405                 410                 415     


Tyr Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser 
            420                 425                 430         


Ser Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile 
        435                 440                 445             


Lys Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu 
    450                 455                 460                 


Arg Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr 
465                 470                 475                 480 


Gly Pro Arg Arg Val Glu Ile Met Glu Glu Glu Ser Glu Gln 
                485                 490                 


<210> 25
<211> 963
<212> PRT
<213> Homo sapiens

<400> 25
Met Ala Glu Gly Gly Gly Cys Arg Glu Arg Pro Asp Ala Glu Thr Gln 
1               5                   10                  15      


Lys Ser Glu Leu Gly Pro Leu Met Arg Thr Thr Leu Gln Arg Gly Ala 
            20                  25                  30          


Gln Trp Tyr Leu Ile Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr 
        35                  40                  45              


Val Gly Phe Asp Ser Trp Asp Met Tyr Asn Val Gly Glu His Asn Leu 
    50                  55                  60                  


Phe Pro Gly Pro Ile Asp Asn Ser Gly Leu Phe Ser Asp Pro Glu Ser 
65                  70                  75                  80  


Gln Thr Leu Lys Glu His Leu Ile Asp Glu Leu Asp Tyr Val Leu Val 
                85                  90                  95      


Pro Thr Glu Ala Trp Asn Lys Leu Leu Asn Trp Tyr Gly Cys Val Glu 
            100                 105                 110         


Gly Gln Gln Pro Ile Val Arg Lys Val Val Glu His Gly Leu Phe Val 
        115                 120                 125             


Lys His Cys Lys Val Glu Val Tyr Leu Leu Glu Leu Lys Leu Cys Glu 
    130                 135                 140                 


Asn Ser Asp Pro Thr Asn Val Leu Ser Cys His Phe Ser Lys Ala Asp 
145                 150                 155                 160 


Thr Ile Ala Thr Ile Glu Lys Glu Met Arg Lys Leu Phe Asn Ile Pro 
                165                 170                 175     


Ala Glu Arg Glu Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Tyr 
            180                 185                 190         


Glu Gln Leu Ser Lys Leu Asp Asn Thr Val Gln Asp Ala Gly Leu Tyr 
        195                 200                 205             


Gln Gly Gln Val Leu Val Ile Glu Pro Gln Asn Glu Asp Gly Thr Trp 
    210                 215                 220                 


Pro Arg Gln Thr Leu Gln Ser Lys Ser Ser Thr Ala Pro Ser Arg Asn 
225                 230                 235                 240 


Phe Thr Thr Ser Pro Lys Ser Ser Ala Ser Pro Tyr Ser Ser Val Ser 
                245                 250                 255     


Ala Ser Leu Ile Ala Asn Gly Asp Ser Thr Ser Thr Cys Gly Met His 
            260                 265                 270         


Ser Ser Gly Val Ser Arg Gly Gly Ser Gly Phe Ser Ala Ser Tyr Asn 
        275                 280                 285             


Cys Gln Glu Pro Pro Ser Ser His Ile Gln Pro Gly Leu Cys Gly Leu 
    290                 295                 300                 


Gly Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Leu Gln Cys Leu 
305                 310                 315                 320 


Ser Asn Thr Ala Pro Leu Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu 
                325                 330                 335     


Ala Glu Ile Asn Arg Asp Asn Pro Leu Gly Met Lys Gly Glu Ile Ala 
            340                 345                 350         


Glu Ala Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly Arg Asp Ala 
        355                 360                 365             


His Val Ala Pro Arg Met Phe Lys Thr Gln Val Gly Arg Phe Ala Pro 
    370                 375                 380                 


Gln Phe Ser Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe 
385                 390                 395                 400 


Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Val Lys Lys Lys Pro 
                405                 410                 415     


Tyr Leu Glu Leu Lys Asp Ala Asn Gly Arg Pro Asp Ala Val Val Ala 
            420                 425                 430         


Lys Glu Ala Trp Glu Asn His Arg Leu Arg Asn Asp Ser Val Ile Val 
        435                 440                 445             


Asp Thr Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys Pro Glu Cys 
    450                 455                 460                 


Ala Lys Val Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro 
465                 470                 475                 480 


Leu Pro Leu Lys Lys Asp Arg Val Met Glu Val Phe Leu Val Pro Ala 
                485                 490                 495     


Asp Pro His Cys Arg Pro Thr Gln Tyr Arg Val Thr Val Pro Leu Met 
            500                 505                 510         


Gly Ala Val Ser Asp Leu Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile 
        515                 520                 525             


Ala Ala Glu Asn Met Val Val Ala Asp Val Tyr Asn His Arg Phe His 
    530                 535                 540                 


Lys Ile Phe Gln Met Asp Glu Gly Leu Asn His Ile Met Pro Arg Asp 
545                 550                 555                 560 


Asp Ile Phe Val Tyr Glu Val Cys Ser Thr Ser Val Asp Gly Ser Glu 
                565                 570                 575     


Cys Val Thr Leu Pro Val Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser 
            580                 585                 590         


Ser Thr Ser Ser Ala Ser Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser 
        595                 600                 605             


Val Pro Lys His Lys Leu Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys 
    610                 615                 620                 


Asp Arg Ile Ser Arg Tyr Val Lys Gln Pro Leu Pro Asp Glu Phe Gly 
625                 630                 635                 640 


Ser Ser Pro Leu Glu Pro Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys 
                645                 650                 655     


Glu Gly Glu Asp Glu Glu Glu Met Glu His Gln Glu Glu Gly Lys Glu 
            660                 665                 670         


Gln Leu Ser Glu Thr Glu Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp 
        675                 680                 685             


Pro Ser Glu Thr Thr Gln Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys 
    690                 695                 700                 


Arg Leu Phe Thr Phe Ser Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile 
705                 710                 715                 720 


Asn Ser Leu Ala Ala Asp Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser 
                725                 730                 735     


Thr Leu Ala Met Asp Trp Asp Ser Glu Thr Arg Arg Leu Tyr Tyr Asp 
            740                 745                 750         


Glu Gln Glu Ser Glu Ala Tyr Glu Lys His Val Ser Met Leu Gln Pro 
        755                 760                 765             


Gln Lys Lys Lys Lys Thr Thr Val Ala Leu Arg Asp Cys Ile Glu Leu 
    770                 775                 780                 


Phe Thr Thr Met Glu Thr Leu Gly Glu His Asp Pro Trp Tyr Cys Pro 
785                 790                 795                 800 


Asn Cys Lys Lys His Gln Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser 
                805                 810                 815     


Leu Pro Lys Ile Leu Val Val His Leu Lys Arg Phe Ser Tyr Asn Arg 
            820                 825                 830         


Tyr Trp Arg Asp Lys Leu Asp Thr Val Val Glu Phe Pro Ile Arg Gly 
        835                 840                 845             


Leu Asn Met Ser Glu Phe Val Cys Asn Leu Ser Ala Arg Pro Tyr Val 
    850                 855                 860                 


Tyr Asp Leu Ile Ala Val Ser Asn His Tyr Gly Ala Met Gly Val Gly 
865                 870                 875                 880 


His Tyr Thr Ala Tyr Ala Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr 
                885                 890                 895     


Phe Asp Asp Ser Asn Val Ser Leu Ala Ser Glu Asp Gln Ile Val Thr 
            900                 905                 910         


Lys Ala Ala Tyr Val Leu Phe Tyr Gln Arg Arg Asp Asp Glu Phe Tyr 
        915                 920                 925             


Lys Thr Pro Ser Leu Ser Ser Ser Gly Ser Ser Asp Gly Gly Thr Arg 
    930                 935                 940                 


Pro Ser Ser Ser Gln Gln Gly Phe Gly Asp Asp Glu Ala Cys Ser Met 
945                 950                 955                 960 


Asp Thr Asn 
            


<210> 26
<211> 913
<212> PRT
<213> Homo sapiens

<400> 26
Met Ala Ala Leu Phe Leu Arg Gly Phe Val Gln Ile Gly Asn Cys Lys 
1               5                   10                  15      


Thr Gly Ile Ser Lys Ser Lys Glu Ala Phe Ile Glu Ala Val Glu Arg 
            20                  25                  30          


Lys Lys Lys Asp Arg Leu Val Leu Tyr Phe Lys Ser Gly Lys Tyr Ser 
        35                  40                  45              


Thr Phe Arg Leu Ser Asp Asn Ile Gln Asn Val Val Leu Lys Ser Tyr 
    50                  55                  60                  


Arg Gly Asn Gln Asn His Leu His Leu Thr Leu Gln Asn Asn Asn Gly 
65                  70                  75                  80  


Leu Phe Ile Glu Gly Leu Ser Ser Thr Asp Ala Glu Gln Leu Lys Ile 
                85                  90                  95      


Phe Leu Asp Arg Val His Gln Asn Glu Val Gln Pro Pro Val Arg Pro 
            100                 105                 110         


Gly Lys Gly Gly Ser Val Phe Ser Ser Thr Thr Gln Lys Glu Ile Asn 
        115                 120                 125             


Lys Thr Ser Phe His Lys Val Asp Glu Lys Ser Ser Ser Lys Ser Phe 
    130                 135                 140                 


Glu Ile Ala Lys Gly Ser Gly Thr Gly Val Leu Gln Arg Met Pro Leu 
145                 150                 155                 160 


Leu Thr Ser Lys Leu Thr Leu Thr Cys Gly Glu Leu Ser Glu Asn Gln 
                165                 170                 175     


His Lys Lys Arg Lys Arg Met Leu Ser Ser Ser Ser Glu Met Asn Glu 
            180                 185                 190         


Glu Phe Leu Lys Glu Asn Asn Ser Val Glu Tyr Lys Lys Ser Lys Ala 
        195                 200                 205             


Asp Cys Ser Arg Cys Val Ser Tyr Asn Arg Glu Lys Gln Leu Lys Leu 
    210                 215                 220                 


Lys Glu Leu Glu Glu Asn Lys Lys Leu Glu Cys Glu Ser Ser Cys Ile 
225                 230                 235                 240 


Met Asn Ala Thr Gly Asn Pro Tyr Leu Asp Asp Ile Gly Leu Leu Gln 
                245                 250                 255     


Ala Leu Thr Glu Lys Met Val Leu Val Phe Leu Leu Gln Gln Gly Tyr 
            260                 265                 270         


Ser Asp Gly Tyr Thr Lys Trp Asp Lys Leu Lys Leu Phe Phe Glu Leu 
        275                 280                 285             


Phe Pro Glu Lys Ile Cys His Gly Leu Pro Asn Leu Gly Asn Thr Cys 
    290                 295                 300                 


Tyr Met Asn Ala Val Leu Gln Ser Leu Leu Ser Ile Pro Ser Phe Ala 
305                 310                 315                 320 


Asp Asp Leu Leu Asn Gln Ser Phe Pro Trp Gly Lys Ile Pro Leu Asn 
                325                 330                 335     


Ala Leu Thr Met Cys Leu Ala Arg Leu Leu Phe Phe Lys Asp Thr Tyr 
            340                 345                 350         


Asn Ile Glu Ile Lys Glu Met Leu Leu Leu Asn Leu Lys Lys Ala Ile 
        355                 360                 365             


Ser Ala Ala Ala Glu Ile Phe His Gly Asn Ala Gln Asn Asp Ala His 
    370                 375                 380                 


Glu Phe Leu Ala His Cys Leu Asp Gln Leu Lys Asp Asn Met Glu Lys 
385                 390                 395                 400 


Leu Asn Thr Ile Trp Lys Pro Lys Ser Glu Phe Gly Glu Asp Asn Phe 
                405                 410                 415     


Pro Lys Gln Val Phe Ala Asp Asp Pro Asp Thr Ser Gly Phe Ser Cys 
            420                 425                 430         


Pro Val Ile Thr Asn Phe Glu Leu Glu Leu Leu His Ser Ile Ala Cys 
        435                 440                 445             


Lys Ala Cys Gly Gln Val Ile Leu Lys Thr Glu Leu Asn Asn Tyr Leu 
    450                 455                 460                 


Ser Ile Asn Leu Pro Gln Arg Ile Lys Ala His Pro Ser Ser Ile Gln 
465                 470                 475                 480 


Ser Thr Phe Asp Leu Phe Phe Gly Ala Glu Glu Leu Glu Tyr Lys Cys 
                485                 490                 495     


Ala Lys Cys Glu His Lys Thr Ser Val Gly Val His Ser Phe Ser Arg 
            500                 505                 510         


Leu Pro Arg Ile Leu Ile Val His Leu Lys Arg Tyr Ser Leu Asn Glu 
        515                 520                 525             


Phe Cys Ala Leu Lys Lys Asn Asp Gln Glu Val Ile Ile Ser Lys Tyr 
    530                 535                 540                 


Leu Lys Val Ser Ser His Cys Asn Glu Gly Thr Arg Pro Pro Leu Pro 
545                 550                 555                 560 


Leu Ser Glu Asp Gly Glu Ile Thr Asp Phe Gln Leu Leu Lys Val Ile 
                565                 570                 575     


Arg Lys Met Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys 
            580                 585                 590         


Glu Ser Lys Asp Ile Leu Ala Pro His Ile Gly Ser Asp Lys Glu Ser 
        595                 600                 605             


Glu Gln Lys Lys Gly Gln Thr Val Phe Lys Gly Ala Ser Arg Arg Gln 
    610                 615                 620                 


Gln Gln Lys Tyr Leu Gly Lys Asn Ser Lys Pro Asn Glu Leu Glu Ser 
625                 630                 635                 640 


Val Tyr Ser Gly Asp Arg Ala Phe Ile Glu Lys Glu Pro Leu Ala His 
                645                 650                 655     


Leu Met Thr Tyr Leu Glu Asp Thr Ser Leu Cys Gln Phe His Lys Ala 
            660                 665                 670         


Gly Gly Lys Pro Ala Ser Ser Pro Gly Thr Pro Leu Ser Lys Val Asp 
        675                 680                 685             


Phe Gln Thr Val Pro Glu Asn Pro Lys Arg Lys Lys Tyr Val Lys Thr 
    690                 695                 700                 


Ser Lys Phe Val Ala Phe Asp Arg Ile Ile Asn Pro Thr Lys Asp Leu 
705                 710                 715                 720 


Tyr Glu Asp Lys Asn Ile Arg Ile Pro Glu Arg Phe Gln Lys Val Ser 
                725                 730                 735     


Glu Gln Thr Gln Gln Cys Asp Gly Met Arg Ile Cys Glu Gln Ala Pro 
            740                 745                 750         


Gln Gln Ala Leu Pro Gln Ser Phe Pro Lys Pro Gly Thr Gln Gly His 
        755                 760                 765             


Thr Lys Asn Leu Leu Arg Pro Thr Lys Leu Asn Leu Gln Lys Ser Asn 
    770                 775                 780                 


Arg Asn Ser Leu Leu Ala Leu Gly Ser Asn Lys Asn Pro Arg Asn Lys 
785                 790                 795                 800 


Asp Ile Leu Asp Lys Ile Lys Ser Lys Ala Lys Glu Thr Lys Arg Asn 
                805                 810                 815     


Asp Asp Lys Gly Asp His Thr Tyr Arg Leu Ile Ser Val Val Ser His 
            820                 825                 830         


Leu Gly Lys Thr Leu Lys Ser Gly His Tyr Ile Cys Asp Ala Tyr Asp 
        835                 840                 845             


Phe Glu Lys Gln Ile Trp Phe Thr Tyr Asp Asp Met Arg Val Leu Gly 
    850                 855                 860                 


Ile Gln Glu Ala Gln Met Gln Glu Asp Arg Arg Cys Thr Gly Tyr Ile 
865                 870                 875                 880 


Phe Phe Tyr Met His Asn Glu Ile Phe Glu Glu Met Leu Lys Arg Glu 
                885                 890                 895     


Glu Asn Ala Gln Leu Asn Ser Lys Glu Val Glu Glu Thr Leu Gln Lys 
            900                 905                 910         


Glu 
    


<210> 27
<211> 1318
<212> PRT
<213> Homo sapiens

<400> 27
Met Ser Gly Gly Ala Ser Ala Thr Gly Pro Arg Arg Gly Pro Pro Gly 
1               5                   10                  15      


Leu Glu Asp Thr Thr Ser Lys Lys Lys Gln Lys Asp Arg Ala Asn Gln 
            20                  25                  30          


Glu Ser Lys Asp Gly Asp Pro Arg Lys Glu Thr Gly Ser Arg Tyr Val 
        35                  40                  45              


Ala Gln Ala Gly Leu Glu Pro Leu Ala Ser Gly Asp Pro Ser Ala Ser 
    50                  55                  60                  


Ala Ser His Ala Ala Gly Ile Thr Gly Ser Arg His Arg Thr Arg Leu 
65                  70                  75                  80  


Phe Phe Pro Ser Ser Ser Gly Ser Ala Ser Thr Pro Gln Glu Glu Gln 
                85                  90                  95      


Thr Lys Glu Gly Ala Cys Glu Asp Pro His Asp Leu Leu Ala Thr Pro 
            100                 105                 110         


Thr Pro Glu Leu Leu Leu Asp Trp Arg Gln Ser Ala Glu Glu Val Ile 
        115                 120                 125             


Val Lys Leu Arg Val Gly Val Gly Pro Leu Gln Leu Glu Asp Val Asp 
    130                 135                 140                 


Ala Ala Phe Thr Asp Thr Asp Cys Val Val Arg Phe Ala Gly Gly Gln 
145                 150                 155                 160 


Gln Trp Gly Gly Val Phe Tyr Ala Glu Ile Lys Ser Ser Cys Ala Lys 
                165                 170                 175     


Val Gln Thr Arg Lys Gly Ser Leu Leu His Leu Thr Leu Pro Lys Lys 
            180                 185                 190         


Val Pro Met Leu Thr Trp Pro Ser Leu Leu Val Glu Ala Asp Glu Gln 
        195                 200                 205             


Leu Cys Ile Pro Pro Leu Asn Ser Gln Thr Cys Leu Leu Gly Ser Glu 
    210                 215                 220                 


Glu Asn Leu Ala Pro Leu Ala Gly Glu Lys Ala Val Pro Pro Gly Asn 
225                 230                 235                 240 


Asp Pro Val Ser Pro Ala Met Val Arg Ser Arg Asn Pro Gly Lys Asp 
                245                 250                 255     


Asp Cys Ala Lys Glu Glu Met Ala Val Ala Ala Asp Ala Ala Thr Leu 
            260                 265                 270         


Val Asp Glu Pro Glu Ser Met Val Asn Leu Ala Phe Val Lys Asn Asp 
        275                 280                 285             


Ser Tyr Glu Lys Gly Pro Asp Ser Val Val Val His Val Tyr Val Lys 
    290                 295                 300                 


Glu Ile Cys Arg Asp Thr Ser Arg Val Leu Phe Arg Glu Gln Asp Phe 
305                 310                 315                 320 


Thr Leu Ile Phe Gln Thr Arg Asp Gly Asn Phe Leu Arg Leu His Pro 
                325                 330                 335     


Gly Cys Gly Pro His Thr Thr Phe Arg Trp Gln Val Lys Leu Arg Asn 
            340                 345                 350         


Leu Ile Glu Pro Glu Gln Cys Thr Phe Cys Phe Thr Ala Ser Arg Ile 
        355                 360                 365             


Asp Ile Cys Leu Arg Lys Arg Gln Ser Gln Arg Trp Gly Gly Leu Glu 
    370                 375                 380                 


Ala Pro Ala Ala Arg Val Gly Gly Ala Lys Val Ala Val Pro Thr Gly 
385                 390                 395                 400 


Pro Thr Pro Leu Asp Ser Thr Pro Pro Gly Gly Ala Pro His Pro Leu 
                405                 410                 415     


Thr Gly Gln Glu Glu Ala Arg Ala Val Glu Lys Asp Lys Ser Lys Ala 
            420                 425                 430         


Arg Ser Glu Asp Thr Gly Leu Asp Ser Val Ala Thr Arg Thr Pro Met 
        435                 440                 445             


Glu His Val Thr Pro Lys Pro Glu Thr His Leu Ala Ser Pro Lys Pro 
    450                 455                 460                 


Thr Cys Met Val Pro Pro Met Pro His Ser Pro Val Ser Gly Asp Ser 
465                 470                 475                 480 


Val Glu Glu Glu Glu Glu Glu Glu Lys Lys Val Cys Leu Pro Gly Phe 
                485                 490                 495     


Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Val Ile 
            500                 505                 510         


Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe Phe His Asp Arg 
        515                 520                 525             


Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu Gly Thr Gly Gly 
    530                 535                 540                 


Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala Leu Trp Lys Gly 
545                 550                 555                 560 


Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala Ile Val Ala Ser 
                565                 570                 575     


Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp Ala Gln Glu Phe 
            580                 585                 590         


Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Gln 
        595                 600                 605             


Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly Arg Pro Asp Glu 
    610                 615                 620                 


Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met Arg Asn Asp Ser 
625                 630                 635                 640 


Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser Lys Leu Val Cys 
                645                 650                 655     


Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro Phe Leu Tyr Leu 
            660                 665                 670         


Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro Val Phe Tyr Phe 
        675                 680                 685             


Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu Val Ser Val Ser 
    690                 695                 700                 


Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser Leu Ser Gln Ser 
705                 710                 715                 720 


Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu Val Ile Lys Asn 
                725                 730                 735     


Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu Asp Thr Val Ser 
            740                 745                 750         


Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser Ser Glu Leu Ala 
        755                 760                 765             


Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg Pro Gln Val Pro 
    770                 775                 780                 


Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg Lys Gln Gln Ser 
785                 790                 795                 800 


Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr Arg Val Gly Tyr 
                805                 810                 815     


Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp His Lys Gly Leu 
            820                 825                 830         


Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val Ser Val Pro Ala 
        835                 840                 845             


Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu Glu Gly Tyr Ala 
    850                 855                 860                 


Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln Pro Gly Arg Met 
865                 870                 875                 880 


Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu Leu Ser Thr Gly 
                885                 890                 895     


Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile Gln Pro Pro Glu 
            900                 905                 910         


Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr Gly Leu Pro Arg 
        915                 920                 925             


Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser Thr Ser Gly Ile 
    930                 935                 940                 


Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val Gly Ser Leu Pro 
945                 950                 955                 960 


Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val Pro Gly Tyr Gln 
                965                 970                 975     


His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln Phe Phe Ile Tyr 
            980                 985                 990         


Lys Ile Asp Ser Ser Asn Arg Glu  Gln Arg Leu Glu Asp  Lys Gly Asp 
        995                 1000                 1005             


Thr Pro  Leu Glu Leu Gly Asp  Asp Cys Ser Leu Ala  Leu Val Trp 
    1010                 1015                 1020             


Arg Asn  Asn Glu Arg Leu Gln  Glu Phe Val Leu Val  Ala Ser Lys 
    1025                 1030                 1035             


Glu Leu  Glu Cys Ala Glu Asp  Pro Gly Ser Ala Gly  Glu Ala Ala 
    1040                 1045                 1050             


Arg Ala  Gly His Phe Thr Leu  Asp Gln Cys Leu Asn  Leu Phe Thr 
    1055                 1060                 1065             


Arg Pro  Glu Val Leu Ala Pro  Glu Glu Ala Trp Tyr  Cys Pro Gln 
    1070                 1075                 1080             


Cys Lys  Gln His Arg Glu Ala  Ser Lys Gln Leu Leu  Leu Trp Arg 
    1085                 1090                 1095             


Leu Pro  Asn Val Leu Ile Val  Gln Leu Lys Arg Phe  Ser Phe Arg 
    1100                 1105                 1110             


Ser Phe  Ile Trp Arg Asp Lys  Ile Asn Asp Leu Val  Glu Phe Pro 
    1115                 1120                 1125             


Val Arg  Asn Leu Asp Leu Ser  Lys Phe Cys Ile Gly  Gln Lys Glu 
    1130                 1135                 1140             


Glu Gln  Leu Pro Ser Tyr Asp  Leu Tyr Ala Val Ile  Asn His Tyr 
    1145                 1150                 1155             


Gly Gly  Met Ile Gly Gly His  Tyr Thr Ala Cys Ala  Arg Leu Pro 
    1160                 1165                 1170             


Asn Asp  Arg Ser Ser Gln Arg  Ser Asp Val Gly Trp  Arg Leu Phe 
    1175                 1180                 1185             


Asp Asp  Ser Thr Val Thr Thr  Val Asp Glu Ser Gln  Val Val Thr 
    1190                 1195                 1200             


Arg Tyr  Ala Tyr Val Leu Phe  Tyr Arg Arg Arg Asn  Ser Pro Val 
    1205                 1210                 1215             


Glu Arg  Pro Pro Arg Ala Gly  His Ser Glu His His  Pro Asp Leu 
    1220                 1225                 1230             


Gly Pro  Ala Ala Glu Ala Ala  Ala Ser Gln Ala Ser  Arg Ile Trp 
    1235                 1240                 1245             


Gln Glu  Leu Glu Ala Glu Glu  Glu Pro Val Pro Glu  Gly Ser Gly 
    1250                 1255                 1260             


Pro Leu  Gly Pro Trp Gly Pro  Gln Asp Trp Val Gly  Pro Leu Pro 
    1265                 1270                 1275             


Arg Gly  Pro Thr Thr Pro Asp  Glu Gly Cys Leu Arg  Tyr Phe Val 
    1280                 1285                 1290             


Leu Gly  Thr Val Ala Ala Leu  Val Ala Leu Val Leu  Asn Val Phe 
    1295                 1300                 1305             


Tyr Pro  Leu Val Ser Gln Ser  Arg Trp Arg 
    1310                 1315             


<210> 28
<211> 798
<212> PRT
<213> Homo sapiens

<400> 28
Met Ala Leu His Ser Pro Gln Tyr Ile Phe Gly Asp Phe Ser Pro Asp 
1               5                   10                  15      


Glu Phe Asn Gln Phe Phe Val Thr Pro Arg Ser Ser Val Glu Leu Pro 
            20                  25                  30          


Pro Tyr Ser Gly Thr Val Leu Cys Gly Thr Gln Ala Val Asp Lys Leu 
        35                  40                  45              


Pro Asp Gly Gln Glu Tyr Gln Arg Ile Glu Phe Gly Val Asp Glu Val 
    50                  55                  60                  


Ile Glu Pro Ser Asp Thr Leu Pro Arg Thr Pro Ser Tyr Ser Ile Ser 
65                  70                  75                  80  


Ser Thr Leu Asn Pro Gln Ala Pro Glu Phe Ile Leu Gly Cys Thr Ala 
                85                  90                  95      


Ser Lys Ile Thr Pro Asp Gly Ile Thr Lys Glu Ala Ser Tyr Gly Ser 
            100                 105                 110         


Ile Asp Cys Gln Tyr Pro Gly Ser Ala Leu Ala Leu Asp Gly Ser Ser 
        115                 120                 125             


Asn Val Glu Ala Glu Val Leu Glu Asn Asp Gly Val Ser Gly Gly Leu 
    130                 135                 140                 


Gly Gln Arg Glu Arg Lys Lys Lys Lys Lys Arg Pro Pro Gly Tyr Tyr 
145                 150                 155                 160 


Ser Tyr Leu Lys Asp Gly Gly Asp Asp Ser Ile Ser Thr Glu Ala Leu 
                165                 170                 175     


Val Asn Gly His Ala Asn Ser Ala Val Pro Asn Ser Val Ser Ala Glu 
            180                 185                 190         


Asp Ala Glu Phe Met Gly Asp Met Pro Pro Ser Val Thr Pro Arg Thr 
        195                 200                 205             


Cys Asn Ser Pro Gln Asn Ser Thr Asp Ser Val Ser Asp Ile Val Pro 
    210                 215                 220                 


Asp Ser Pro Phe Pro Gly Ala Leu Gly Ser Asp Thr Arg Thr Ala Gly 
225                 230                 235                 240 


Gln Pro Glu Gly Gly Pro Gly Ala Asp Phe Gly Gln Ser Cys Phe Pro 
                245                 250                 255     


Ala Glu Ala Gly Arg Asp Thr Leu Ser Arg Thr Ala Gly Ala Gln Pro 
            260                 265                 270         


Cys Val Gly Thr Asp Thr Thr Glu Asn Leu Gly Val Ala Asn Gly Gln 
        275                 280                 285             


Ile Leu Glu Ser Ser Gly Glu Gly Thr Ala Thr Asn Gly Val Glu Leu 
    290                 295                 300                 


His Thr Thr Glu Ser Ile Asp Leu Asp Pro Thr Lys Pro Glu Ser Ala 
305                 310                 315                 320 


Ser Pro Pro Ala Asp Gly Thr Gly Ser Ala Ser Gly Thr Leu Pro Val 
                325                 330                 335     


Ser Gln Pro Lys Ser Trp Ala Ser Leu Phe His Asp Ser Lys Pro Ser 
            340                 345                 350         


Ser Ser Ser Pro Val Ala Tyr Val Glu Thr Lys Tyr Ser Pro Pro Ala 
        355                 360                 365             


Ile Ser Pro Leu Val Ser Glu Lys Gln Val Glu Val Lys Glu Gly Leu 
    370                 375                 380                 


Val Pro Val Ser Glu Asp Pro Val Ala Ile Lys Ile Ala Glu Leu Leu 
385                 390                 395                 400 


Glu Asn Val Thr Leu Ile His Lys Pro Val Ser Leu Gln Pro Arg Gly 
                405                 410                 415     


Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile Asn Ala Thr Leu Gln Ala 
            420                 425                 430         


Leu Val Ala Cys Pro Pro Met Tyr His Leu Met Lys Phe Ile Pro Leu 
        435                 440                 445             


Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser Thr Pro Met Ile Asp Ser 
    450                 455                 460                 


Phe Val Arg Leu Met Asn Glu Phe Thr Asn Met Pro Val Pro Pro Lys 
465                 470                 475                 480 


Pro Arg Gln Ala Leu Gly Asp Lys Ile Val Arg Asp Ile Arg Pro Gly 
                485                 490                 495     


Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg Leu Leu Thr Val Asn Lys 
            500                 505                 510         


Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu Asp Ala Glu Glu Tyr Leu 
        515                 520                 525             


Gly Phe Ile Leu Asn Gly Leu His Glu Glu Met Leu Asn Leu Lys Lys 
    530                 535                 540                 


Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr Ile Ser Asn Gly Pro Lys 
545                 550                 555                 560 


Asn His Ser Val Asn Glu Glu Glu Gln Glu Glu Gln Gly Glu Gly Ser 
                565                 570                 575     


Glu Asp Glu Trp Glu Gln Val Gly Pro Arg Asn Lys Thr Ser Val Thr 
            580                 585                 590         


Arg Gln Ala Asp Phe Val Gln Thr Pro Ile Thr Gly Ile Phe Gly Gly 
        595                 600                 605             


His Ile Arg Ser Val Val Tyr Gln Gln Ser Ser Lys Glu Ser Ala Thr 
    610                 615                 620                 


Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp Ile Gln Ser Asp Lys Ile 
625                 630                 635                 640 


Arg Thr Val Gln Asp Ala Leu Glu Ser Leu Val Ala Arg Glu Ser Val 
                645                 650                 655     


Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu Val Glu Ile Ser Arg Arg 
            660                 665                 670         


Val Thr Leu Glu Lys Leu Pro Pro Val Leu Val Leu His Leu Lys Arg 
        675                 680                 685             


Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln Lys Leu Ile Lys Asn Ile 
    690                 695                 700                 


Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys Glu Leu Leu Ser Pro Gly 
705                 710                 715                 720 


Val Lys Asn Lys Asn Phe Lys Cys His Arg Thr Tyr Arg Leu Phe Ala 
                725                 730                 735     


Val Val Tyr His His Gly Asn Ser Ala Thr Gly Gly His Tyr Thr Thr 
            740                 745                 750         


Asp Val Phe Gln Ile Gly Leu Asn Gly Trp Leu Arg Ile Asp Asp Gln 
        755                 760                 765             


Thr Val Lys Val Ile Asn Gln Tyr Gln Val Val Lys Pro Thr Ala Glu 
    770                 775                 780                 


Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg Val Asp Leu Leu 
785                 790                 795             


<210> 29
<211> 688
<212> PRT
<213> Homo sapiens

<400> 29
Met Asp Arg Cys Lys His Val Gly Arg Leu Arg Leu Ala Gln Asp His 
1               5                   10                  15      


Ser Ile Leu Asn Pro Gln Lys Trp Cys Cys Leu Glu Cys Ala Thr Thr 
            20                  25                  30          


Glu Ser Val Trp Ala Cys Leu Lys Cys Ser His Val Ala Cys Gly Arg 
        35                  40                  45              


Tyr Ile Glu Asp His Ala Leu Lys His Phe Glu Glu Thr Gly His Pro 
    50                  55                  60                  


Leu Ala Met Glu Val Arg Asp Leu Tyr Val Phe Cys Tyr Leu Cys Lys 
65                  70                  75                  80  


Asp Tyr Val Leu Asn Asp Asn Pro Glu Gly Asp Leu Lys Leu Leu Arg 
                85                  90                  95      


Ser Ser Leu Leu Ala Val Arg Gly Gln Lys Gln Asp Thr Pro Val Arg 
            100                 105                 110         


Arg Gly Arg Thr Leu Arg Ser Met Ala Ser Gly Glu Asp Val Val Leu 
        115                 120                 125             


Pro Gln Arg Ala Pro Gln Gly Gln Pro Gln Met Leu Thr Ala Leu Trp 
    130                 135                 140                 


Tyr Arg Arg Gln Arg Leu Leu Ala Arg Thr Leu Arg Leu Trp Phe Glu 
145                 150                 155                 160 


Lys Ser Ser Arg Gly Gln Ala Lys Leu Glu Gln Arg Arg Gln Glu Glu 
                165                 170                 175     


Ala Leu Glu Arg Lys Lys Glu Glu Ala Arg Arg Arg Arg Arg Glu Val 
            180                 185                 190         


Lys Arg Arg Leu Leu Glu Glu Leu Ala Ser Thr Pro Pro Arg Lys Ser 
        195                 200                 205             


Ala Arg Leu Leu Leu His Thr Pro Arg Asp Ala Gly Pro Ala Ala Ser 
    210                 215                 220                 


Arg Pro Ala Ala Leu Pro Thr Ser Arg Arg Val Pro Ala Ala Thr Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Gln Pro Ala Met Ala Pro Gly Val Thr Gly Leu Arg 
                245                 250                 255     


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Ile Leu Gln Val Leu Ser 
            260                 265                 270         


His Leu Gln Lys Phe Arg Glu Cys Phe Leu Asn Leu Asp Pro Ser Lys 
        275                 280                 285             


Thr Glu His Leu Phe Pro Lys Ala Thr Asn Gly Lys Thr Gln Leu Ser 
    290                 295                 300                 


Gly Lys Pro Thr Asn Ser Ser Ala Thr Glu Leu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Arg Ala Glu Ala Cys Glu Arg Glu Gly Phe Cys Trp Asn Gly Arg Ala 
                325                 330                 335     


Ser Ile Ser Arg Ser Leu Glu Leu Ile Gln Asn Lys Glu Pro Ser Ser 
            340                 345                 350         


Lys His Ile Ser Leu Cys Arg Glu Leu His Thr Leu Phe Arg Val Met 
        355                 360                 365             


Trp Ser Gly Lys Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser 
    370                 375                 380                 


Val Trp Ser Leu Ile Pro Ala Phe Arg Gly Tyr Asp Gln Gln Asp Ala 
385                 390                 395                 400 


Gln Glu Phe Leu Cys Glu Leu Leu His Lys Val Gln Gln Glu Leu Glu 
                405                 410                 415     


Ser Glu Gly Thr Thr Arg Arg Ile Leu Ile Pro Phe Ser Gln Arg Lys 
            420                 425                 430         


Leu Thr Lys Gln Val Leu Lys Val Val Asn Thr Ile Phe His Gly Gln 
        435                 440                 445             


Leu Leu Ser Gln Val Thr Cys Ile Ser Cys Asn Tyr Lys Ser Asn Thr 
    450                 455                 460                 


Ile Glu Pro Phe Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr His 
465                 470                 475                 480 


Cys Ile Glu Lys Gly Phe Val Pro Leu Asn Gln Thr Glu Cys Leu Leu 
                485                 490                 495     


Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu Ala Leu Glu Gly Arg 
            500                 505                 510         


Ile Tyr Ala Cys Asp Gln Cys Asn Ser Lys Arg Arg Lys Ser Asn Pro 
        515                 520                 525             


Lys Pro Leu Val Leu Ser Glu Ala Arg Lys Gln Leu Met Ile Tyr Arg 
    530                 535                 540                 


Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg Phe Arg Trp Ser Gly 
545                 550                 555                 560 


Arg Asn His Arg Glu Lys Ile Gly Val His Val Val Phe Asp Gln Val 
                565                 570                 575     


Leu Thr Met Glu Pro Tyr Cys Cys Arg Asp Met Leu Ser Ser Leu Asp 
            580                 585                 590         


Lys Glu Thr Phe Ala Tyr Asp Leu Ser Ala Val Val Met His His Gly 
        595                 600                 605             


Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr Cys Tyr Asn Thr Glu 
    610                 615                 620                 


Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys Leu Asn Val Cys Ser 
625                 630                 635                 640 


Val Glu Glu Val Cys Lys Thr Gln Ala Tyr Ile Leu Phe Tyr Thr Gln 
                645                 650                 655     


Arg Thr Val Gln Gly Asn Ala Arg Ile Ser Glu Thr His Leu Gln Ala 
            660                 665                 670         


Gln Val Gln Ser Ser Asn Asn Asp Glu Gly Arg Pro Gln Thr Phe Ser 
        675                 680                 685             


<210> 30
<211> 530
<212> PRT
<213> Homo sapiens

<400> 30
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Pro Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Leu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr Pro Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Cys Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly Tyr Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Glu Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Met Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Met Asn Ser Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 31
<211> 350
<212> PRT
<213> Homo sapiens

<400> 31
Gly Ser Lys Lys His Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala 
1               5                   10                  15      


Thr Cys Tyr Met Asn Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln 
            20                  25                  30          


Leu Arg Lys Ala Val Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser 
        35                  40                  45              


Lys Ser Val Pro Leu Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His 
    50                  55                  60                  


Ser Asp Lys Pro Val Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp 
65                  70                  75                  80  


Glu Thr Leu Asp Ser Phe Met Gln His Asp Val Gln Glu Leu Cys Arg 
                85                  90                  95      


Val Leu Leu Asp Asn Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu 
            100                 105                 110         


Gly Thr Ile Pro Lys Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln 
        115                 120                 125             


Cys Lys Glu Val Asp Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp 
    130                 135                 140                 


Ile Gln Leu Ser Ile Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val 
145                 150                 155                 160 


Asp Tyr Val Ala Val Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala 
                165                 170                 175     


Gly Glu His Gly Leu Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr 
            180                 185                 190         


Leu Pro Pro Val Leu His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro 
        195                 200                 205             


Gln Thr Asp Gln Asn Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu 
    210                 215                 220                 


Gln Leu Pro Leu Asp Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro 
225                 230                 235                 240 


Ala Asn Tyr Ile Leu His Ala Val Leu Val His Ser Gly Asp Asn His 
                245                 250                 255     


Gly Gly His Tyr Val Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp 
            260                 265                 270         


Cys Lys Phe Asp Asp Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala 
        275                 280                 285             


Ile Glu His Asn Tyr Gly Gly His Asp Asp Asp Leu Ser Val Arg His 
    290                 295                 300                 


Cys Thr Asn Ala Tyr Met Leu Val Tyr Ile Arg Glu Ser Lys Leu Ser 
305                 310                 315                 320 


Glu Val Leu Gln Ala Val Thr Asp His Asp Ile Pro Gln Gln Leu Val 
                325                 330                 335     


Glu Arg Leu Gln Glu Glu Lys Arg Ile Glu Ala Gln Lys Arg 
            340                 345                 350 


<210> 32
<211> 343
<212> PRT
<213> Homo sapiens

<400> 32
Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp Tyr 
            20                  25                  30          


Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn Ala 
        35                  40                  45              


His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile Trp 
    50                  55                  60                  


Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr Gln 
65                  70                  75                  80  


Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val Asn 
            100                 105                 110         


Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His Leu 
        115                 120                 125             


Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu Arg 
    130                 135                 140                 


Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser Ser 
145                 150                 155                 160 


Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro Phe 
                165                 170                 175     


Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val Thr 
            180                 185                 190         


Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp Gly 
        195                 200                 205             


Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys Ile 
    210                 215                 220                 


Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His Leu 
225                 230                 235                 240 


Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr Phe 
                245                 250                 255     


Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser Glu 
            260                 265                 270         


Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His Ser 
        275                 280                 285             


Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro Gly 
    290                 295                 300                 


Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met Ser 
305                 310                 315                 320 


Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu Leu 
                325                 330                 335     


Ala Ser Pro Pro Ser Arg Met 
            340             


<210> 33
<211> 374
<212> PRT
<213> Homo sapiens

<400> 33
Gly Leu Glu Ile Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr 
1               5                   10                  15      


Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser 
            20                  25                  30          


Ser Val Leu Asp Thr Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Val 
        35                  40                  45              


Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile Val Asn 
    50                  55                  60                  


Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met Lys Leu 
65                  70                  75                  80  


Arg Lys Ile Leu Glu Lys Val Glu Ala Ala Ser Gly Phe Thr Ser Glu 
                85                  90                  95      


Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile Leu Phe His His Ile Leu 
            100                 105                 110         


Arg Val Glu Pro Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln 
        115                 120                 125             


Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly 
    130                 135                 140                 


Val Pro Thr Ile Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn 
145                 150                 155                 160 


Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg 
                165                 170                 175     


Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu 
            180                 185                 190         


Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile 
        195                 200                 205             


Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro 
    210                 215                 220                 


Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr 
225                 230                 235                 240 


Gln Val His Leu His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val 
                245                 250                 255     


Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile 
            260                 265                 270         


Pro Cys Gln Asn Met Glu Leu Phe Ala Val Leu Cys Ile Glu Thr Ser 
        275                 280                 285             


His Tyr Val Ala Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu 
    290                 295                 300                 


Phe Phe Asp Ser Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn 
305                 310                 315                 320 


Ile Pro Gln Val Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met 
                325                 330                 335     


Ser Leu Glu Asp Leu His Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys 
            340                 345                 350         


Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln Ser Pro 
        355                 360                 365             


Thr Met Ser Leu Tyr Lys 
    370                 


<210> 34
<211> 530
<212> PRT
<213> Homo sapiens

<400> 34
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 35
<211> 525
<212> PRT
<213> Homo sapiens

<400> 35
Met Val Ser Arg Pro Glu Pro Glu Gly Glu Ala Met Asp Ala Glu Leu 
1               5                   10                  15      


Ala Val Ala Pro Pro Gly Cys Ser His Leu Gly Ser Phe Lys Val Asp 
            20                  25                  30          


Asn Trp Lys Gln Asn Leu Arg Ala Ile Tyr Gln Cys Phe Val Trp Ser 
        35                  40                  45              


Gly Thr Ala Glu Ala Arg Lys Arg Lys Ala Lys Ser Cys Ile Cys His 
    50                  55                  60                  


Val Cys Gly Val His Leu Asn Arg Leu His Ser Cys Leu Tyr Cys Val 
65                  70                  75                  80  


Phe Phe Gly Cys Phe Thr Lys Lys His Ile His Glu His Ala Lys Ala 
                85                  90                  95      


Lys Arg His Asn Leu Ala Ile Asp Leu Met Tyr Gly Gly Ile Tyr Cys 
            100                 105                 110         


Phe Leu Cys Gln Asp Tyr Ile Tyr Asp Lys Asp Met Glu Ile Ile Ala 
        115                 120                 125             


Lys Glu Glu Gln Arg Lys Ala Trp Lys Met Gln Gly Val Gly Glu Lys 
    130                 135                 140                 


Phe Ser Thr Trp Glu Pro Thr Lys Arg Glu Leu Glu Leu Leu Lys His 
145                 150                 155                 160 


Asn Pro Lys Arg Arg Lys Ile Thr Ser Asn Cys Thr Ile Gly Leu Arg 
                165                 170                 175     


Gly Leu Ile Asn Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln 
            180                 185                 190         


Ala Leu Thr His Thr Pro Leu Leu Arg Asp Phe Phe Leu Ser Asp Arg 
        195                 200                 205             


His Arg Cys Glu Met Gln Ser Pro Ser Ser Cys Leu Val Cys Glu Met 
    210                 215                 220                 


Ser Ser Leu Phe Gln Glu Phe Tyr Ser Gly His Arg Ser Pro His Ile 
225                 230                 235                 240 


Pro Tyr Lys Leu Leu His Leu Val Trp Thr His Ala Arg His Leu Ala 
                245                 250                 255     


Gly Tyr Glu Gln Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp 
            260                 265                 270         


Val Leu His Arg His Cys Lys Gly Asp Asp Asn Gly Lys Lys Ala Asn 
        275                 280                 285             


Asn Pro Asn His Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly 
    290                 295                 300                 


Leu Gln Ser Asp Val Thr Cys Gln Val Cys His Gly Val Ser Thr Thr 
305                 310                 315                 320 


Ile Asp Pro Phe Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Ser Thr 
                325                 330                 335     


Pro Phe Trp Pro Leu Ser Pro Gly Ser Glu Gly Asn Val Val Asn Gly 
            340                 345                 350         


Glu Ser His Val Ser Gly Thr Thr Thr Leu Thr Asp Cys Leu Arg Arg 
        355                 360                 365             


Phe Thr Arg Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Ser 
    370                 375                 380                 


Gly Cys His Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys 
385                 390                 395                 400 


Leu Pro Ile Val Ala Cys Phe His Leu Lys Arg Phe Glu His Ser Ala 
                405                 410                 415     


Lys Leu Arg Arg Lys Ile Thr Thr Tyr Val Ser Phe Pro Leu Glu Leu 
            420                 425                 430         


Asp Met Thr Pro Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly 
        435                 440                 445             


Gln Tyr Gln Gln Pro Thr Asp Ser Leu Asn Asn Asp Asn Lys Tyr Ser 
    450                 455                 460                 


Leu Phe Ala Val Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr 
465                 470                 475                 480 


Thr Ser Phe Ile Arg Gln His Lys Asp Gln Trp Phe Lys Cys Asp Asp 
                485                 490                 495     


Ala Ile Ile Thr Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly 
            500                 505                 510         


Tyr Leu Leu Phe Tyr His Lys Gln Phe Leu Glu Tyr Glu 
        515                 520                 525 


<210> 36
<211> 372
<212> PRT
<213> Homo sapiens

<400> 36
Met Ser Lys Ala Phe Gly Leu Leu Arg Gln Ile Cys Gln Ser Ile Leu 
1               5                   10                  15      


Ala Glu Ser Ser Gln Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu 
            20                  25                  30          


Asp Ser Asn Met Lys Arg Glu Gln Pro Arg Glu Arg Pro Arg Ala Trp 
        35                  40                  45              


Asp Tyr Pro His Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Thr 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Cys Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Thr Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Thr Ile Arg Val Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp Gln Glu Thr Ala Tyr Leu Leu Val Tyr Met 
        355                 360                 365             


Lys Met Glu Cys 
    370         


<210> 37
<211> 1077
<212> PRT
<213> Homo sapiens

<400> 37
Met Thr Ala Glu Leu Gln Gln Asp Asp Ala Ala Gly Ala Ala Asp Gly 
1               5                   10                  15      


His Gly Ser Ser Cys Gln Met Leu Leu Asn Gln Leu Arg Glu Ile Thr 
            20                  25                  30          


Gly Ile Gln Asp Pro Ser Phe Leu His Glu Ala Leu Lys Ala Ser Asn 
        35                  40                  45              


Gly Asp Ile Thr Gln Ala Val Ser Leu Leu Thr Asp Glu Arg Val Lys 
    50                  55                  60                  


Glu Pro Ser Gln Asp Thr Val Ala Thr Glu Pro Ser Glu Val Glu Gly 
65                  70                  75                  80  


Ser Ala Ala Asn Lys Glu Val Leu Ala Lys Val Ile Asp Leu Thr His 
                85                  90                  95      


Asp Asn Lys Asp Asp Leu Gln Ala Ala Ile Ala Leu Ser Leu Leu Glu 
            100                 105                 110         


Ser Pro Lys Ile Gln Ala Asp Gly Arg Asp Leu Asn Arg Met His Glu 
        115                 120                 125             


Ala Thr Ser Ala Glu Thr Lys Arg Ser Lys Arg Lys Arg Cys Glu Val 
    130                 135                 140                 


Trp Gly Glu Asn Pro Asn Pro Asn Asp Trp Arg Arg Val Asp Gly Trp 
145                 150                 155                 160 


Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val 
                165                 170                 175     


Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val Leu Ser 
            180                 185                 190         


Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His Thr Glu 
        195                 200                 205             


Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe Ala Leu 
    210                 215                 220                 


Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala Leu Asp 
225                 230                 235                 240 


Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln Asp Val 
                245                 250                 255     


Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln 
            260                 265                 270         


Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn Pro Met 
        275                 280                 285             


Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg Glu Gly 
    290                 295                 300                 


Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu Gln Val 
305                 310                 315                 320 


Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met Val Glu 
                325                 330                 335     


Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr Gly Gln 
            340                 345                 350         


Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu Leu Ser 
        355                 360                 365             


Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile His Asn 
    370                 375                 380                 


Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met Tyr Arg 
385                 390                 395                 400 


Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys Leu Lys 
                405                 410                 415     


Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val Lys Tyr 
            420                 425                 430         


Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys Tyr Val 
        435                 440                 445             


Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro Pro Glu 
    450                 455                 460                 


Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys Ser Val 
465                 470                 475                 480 


Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser Ser Gln 
                485                 490                 495     


Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro Lys Ser 
            500                 505                 510         


Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser Gln Pro 
        515                 520                 525             


Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys Thr Cys 
    530                 535                 540                 


Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp Leu Lys 
545                 550                 555                 560 


Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr Cys Asp 
                565                 570                 575     


Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu Val His 
            580                 585                 590         


Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr Asn Gln 
        595                 600                 605             


Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr Glu Ser 
    610                 615                 620                 


Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg Asn Val 
625                 630                 635                 640 


Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr Phe Asn 
                645                 650                 655     


Ala Glu Ala Ala Pro Thr Glu Ser Asp Gln Met Ser Glu Val Glu Ala 
            660                 665                 670         


Leu Ser Val Glu Leu Lys His Tyr Ile Gln Glu Asp Asn Trp Arg Phe 
        675                 680                 685             


Glu Gln Glu Val Glu Glu Trp Glu Glu Glu Gln Ser Cys Lys Ile Pro 
    690                 695                 700                 


Gln Met Glu Ser Ser Thr Asn Ser Ser Ser Gln Asp Tyr Ser Thr Ser 
705                 710                 715                 720 


Gln Glu Pro Ser Val Ala Ser Ser His Gly Val Arg Cys Leu Ser Ser 
                725                 730                 735     


Glu His Ala Val Ile Val Lys Glu Gln Thr Ala Gln Ala Ile Ala Asn 
            740                 745                 750         


Thr Ala Arg Ala Tyr Glu Lys Ser Gly Val Glu Ala Ala Leu Ser Glu 
        755                 760                 765             


Val Met Leu Ser Pro Ala Met Gln Gly Val Ile Leu Ala Ile Ala Lys 
    770                 775                 780                 


Ala Arg Gln Thr Phe Asp Arg Asp Gly Ser Glu Ala Gly Leu Ile Lys 
785                 790                 795                 800 


Ala Phe His Glu Glu Tyr Ser Arg Leu Tyr Gln Leu Ala Lys Glu Thr 
                805                 810                 815     


Pro Thr Ser His Ser Asp Pro Arg Leu Gln His Val Leu Val Tyr Phe 
            820                 825                 830         


Phe Gln Asn Glu Ala Pro Lys Arg Val Val Glu Arg Thr Leu Leu Glu 
        835                 840                 845             


Gln Phe Ala Asp Lys Asn Leu Ser Tyr Asp Glu Arg Ser Ile Ser Ile 
    850                 855                 860                 


Met Lys Val Ala Gln Ala Lys Leu Lys Glu Ile Gly Pro Asp Asp Met 
865                 870                 875                 880 


Asn Met Glu Glu Tyr Lys Lys Trp His Glu Asp Tyr Ser Leu Phe Arg 
                885                 890                 895     


Lys Val Ser Val Tyr Leu Leu Thr Gly Leu Glu Leu Tyr Gln Lys Gly 
            900                 905                 910         


Lys Tyr Gln Glu Ala Leu Ser Tyr Leu Val Tyr Ala Tyr Gln Ser Asn 
        915                 920                 925             


Ala Ala Leu Leu Met Lys Gly Pro Arg Arg Gly Val Lys Glu Ser Val 
    930                 935                 940                 


Ile Ala Leu Tyr Arg Arg Lys Cys Leu Leu Glu Leu Asn Ala Lys Ala 
945                 950                 955                 960 


Ala Ser Leu Phe Glu Thr Asn Asp Asp His Ser Val Thr Glu Gly Ile 
                965                 970                 975     


Asn Val Met Asn Glu Leu Ile Ile Pro Cys Ile His Leu Ile Ile Asn 
            980                 985                 990         


Asn Asp Ile Ser Lys Asp Asp Leu  Asp Ala Ile Glu Val  Met Arg Asn 
        995                 1000                 1005             


His Trp  Cys Ser Tyr Leu Gly  Gln Asp Ile Ala Glu  Asn Leu Gln 
    1010                 1015                 1020             


Leu Cys  Leu Gly Glu Phe Leu  Pro Arg Leu Leu Asp  Pro Ser Ala 
    1025                 1030                 1035             


Glu Ile  Ile Val Leu Lys Glu  Pro Pro Thr Ile Arg  Pro Asn Ser 
    1040                 1045                 1050             


Pro Tyr  Asp Leu Cys Ser Arg  Phe Ala Ala Val Met  Glu Ser Ile 
    1055                 1060                 1065             


Gln Gly  Val Ser Thr Val Thr  Val Lys 
    1070                 1075         


<210> 38
<211> 530
<212> PRT
<213> Homo sapiens

<400> 38
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Ala Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Lys Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Lys Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu Arg Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Val Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 39
<211> 1352
<212> PRT
<213> Homo sapiens

<400> 39
Met Ser Lys Val Thr Ala Pro Gly Ser Gly Pro Pro Ala Ala Ala Ser 
1               5                   10                  15      


Gly Lys Glu Lys Arg Ser Phe Ser Lys Arg Leu Phe Arg Ser Gly Arg 
            20                  25                  30          


Ala Gly Gly Gly Gly Ala Gly Gly Pro Gly Ala Ser Gly Pro Ala Ala 
        35                  40                  45              


Pro Ser Ser Pro Ser Ser Pro Ser Ser Ala Arg Ser Val Gly Ser Phe 
    50                  55                  60                  


Met Ser Arg Val Leu Lys Thr Leu Ser Thr Leu Ser His Leu Ser Ser 
65                  70                  75                  80  


Glu Gly Ala Ala Pro Asp Arg Gly Gly Leu Arg Ser Cys Phe Pro Pro 
                85                  90                  95      


Gly Pro Ala Ala Ala Pro Thr Pro Pro Pro Cys Pro Pro Pro Pro Ala 
            100                 105                 110         


Ser Pro Ala Pro Pro Ala Cys Ala Ala Glu Pro Val Pro Gly Val Ala 
        115                 120                 125             


Gly Leu Arg Asn His Gly Asn Thr Cys Phe Met Asn Ala Thr Leu Gln 
    130                 135                 140                 


Cys Leu Ser Asn Thr Glu Leu Phe Ala Glu Tyr Leu Ala Leu Gly Gln 
145                 150                 155                 160 


Tyr Arg Ala Gly Arg Pro Glu Pro Ser Pro Asp Pro Glu Gln Pro Ala 
                165                 170                 175     


Gly Arg Gly Ala Gln Gly Gln Gly Glu Val Thr Glu Gln Leu Ala His 
            180                 185                 190         


Leu Val Arg Ala Leu Trp Thr Leu Glu Tyr Thr Pro Gln His Ser Arg 
        195                 200                 205             


Asp Phe Lys Thr Ile Val Ser Lys Asn Ala Leu Gln Tyr Arg Gly Asn 
    210                 215                 220                 


Ser Gln His Asp Ala Gln Glu Phe Leu Leu Trp Leu Leu Asp Arg Val 
225                 230                 235                 240 


His Glu Asp Leu Asn His Ser Val Lys Gln Ser Gly Gln Pro Pro Leu 
                245                 250                 255     


Lys Pro Pro Ser Glu Thr Asp Met Met Pro Glu Gly Pro Ser Phe Pro 
            260                 265                 270         


Val Cys Ser Thr Phe Val Gln Glu Leu Phe Gln Ala Gln Tyr Arg Ser 
        275                 280                 285             


Ser Leu Thr Cys Pro His Cys Gln Lys Gln Ser Asn Thr Phe Asp Pro 
    290                 295                 300                 


Phe Leu Cys Ile Ser Leu Pro Ile Pro Leu Pro His Thr Arg Pro Leu 
305                 310                 315                 320 


Tyr Val Thr Val Val Tyr Gln Gly Lys Cys Ser His Cys Met Arg Ile 
                325                 330                 335     


Gly Val Ala Val Pro Leu Ser Gly Thr Val Ala Arg Leu Arg Glu Ala 
            340                 345                 350         


Val Ser Met Glu Thr Lys Ile Pro Thr Asp Gln Ile Val Leu Thr Glu 
        355                 360                 365             


Met Tyr Tyr Asp Gly Phe His Arg Ser Phe Cys Asp Thr Asp Asp Leu 
    370                 375                 380                 


Glu Thr Val His Glu Ser Asp Cys Ile Phe Ala Phe Glu Thr Pro Glu 
385                 390                 395                 400 


Ile Phe Arg Pro Glu Gly Ile Leu Ser Gln Arg Gly Ile His Leu Asn 
                405                 410                 415     


Asn Asn Leu Asn His Leu Lys Phe Gly Leu Asp Tyr His Arg Leu Ser 
            420                 425                 430         


Ser Pro Thr Gln Thr Ala Ala Lys Gln Gly Lys Met Asp Ser Pro Thr 
        435                 440                 445             


Ser Arg Ala Gly Ser Asp Lys Ile Val Leu Leu Val Cys Asn Arg Ala 
    450                 455                 460                 


Cys Thr Gly Gln Gln Gly Lys Arg Phe Gly Leu Pro Phe Val Leu His 
465                 470                 475                 480 


Leu Glu Lys Thr Ile Ala Trp Asp Leu Leu Gln Lys Glu Ile Leu Glu 
                485                 490                 495     


Lys Met Lys Tyr Phe Leu Arg Pro Thr Val Cys Ile Gln Val Cys Pro 
            500                 505                 510         


Phe Ser Leu Arg Val Val Ser Val Val Gly Ile Thr Tyr Leu Leu Pro 
        515                 520                 525             


Gln Glu Glu Gln Pro Leu Cys His Pro Ile Val Glu Arg Ala Leu Lys 
    530                 535                 540                 


Ser Cys Gly Pro Gly Gly Thr Ala His Val Lys Leu Val Val Glu Trp 
545                 550                 555                 560 


Asp Lys Glu Thr Arg Asp Phe Leu Phe Val Asn Thr Glu Asp Glu Tyr 
                565                 570                 575     


Ile Pro Asp Ala Glu Ser Val Arg Leu Gln Arg Glu Arg His His Gln 
            580                 585                 590         


Pro Gln Thr Cys Thr Leu Ser Gln Cys Phe Gln Leu Tyr Thr Lys Glu 
        595                 600                 605             


Glu Arg Leu Ala Pro Asp Asp Ala Trp Arg Cys Pro His Cys Lys Gln 
    610                 615                 620                 


Leu Gln Gln Gly Ser Ile Thr Leu Ser Leu Trp Thr Leu Pro Asp Val 
625                 630                 635                 640 


Leu Ile Ile His Leu Lys Arg Phe Arg Gln Glu Gly Asp Arg Arg Met 
                645                 650                 655     


Lys Leu Gln Asn Met Val Lys Phe Pro Leu Thr Gly Leu Asp Met Thr 
            660                 665                 670         


Pro His Val Val Lys Arg Ser Gln Ser Ser Trp Ser Leu Pro Ser His 
        675                 680                 685             


Trp Ser Pro Trp Arg Arg Pro Tyr Gly Leu Gly Arg Asp Pro Glu Asp 
    690                 695                 700                 


Tyr Ile Tyr Asp Leu Tyr Ala Val Cys Asn His His Gly Thr Met Gln 
705                 710                 715                 720 


Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn Ser Val Asp Gly Leu Trp 
                725                 730                 735     


Tyr Cys Phe Asp Asp Ser Asp Val Gln Gln Leu Ser Glu Asp Glu Val 
            740                 745                 750         


Cys Thr Gln Thr Ala Tyr Ile Leu Phe Tyr Gln Arg Arg Thr Ala Ile 
        755                 760                 765             


Pro Ser Trp Ser Ala Asn Ser Ser Val Ala Gly Ser Thr Ser Ser Ser 
    770                 775                 780                 


Leu Cys Glu His Trp Val Ser Arg Leu Pro Gly Ser Lys Pro Ala Ser 
785                 790                 795                 800 


Val Thr Ser Ala Ala Ser Ser Arg Arg Thr Ser Leu Ala Ser Leu Ser 
                805                 810                 815     


Glu Ser Val Glu Met Thr Gly Glu Arg Ser Glu Asp Asp Gly Gly Phe 
            820                 825                 830         


Ser Thr Arg Pro Phe Val Arg Ser Val Gln Arg Gln Ser Leu Ser Ser 
        835                 840                 845             


Arg Ser Ser Val Thr Ser Pro Leu Ala Val Asn Glu Asn Cys Met Arg 
    850                 855                 860                 


Pro Ser Trp Ser Leu Ser Ala Lys Leu Gln Met Arg Ser Asn Ser Pro 
865                 870                 875                 880 


Ser Arg Phe Ser Gly Asp Ser Pro Ile His Ser Ser Ala Ser Thr Leu 
                885                 890                 895     


Glu Lys Ile Gly Glu Ala Ala Asp Asp Lys Val Ser Ile Ser Cys Phe 
            900                 905                 910         


Gly Ser Leu Arg Asn Leu Ser Ser Ser Tyr Gln Glu Pro Ser Asp Ser 
        915                 920                 925             


His Ser Arg Arg Glu His Lys Ala Val Gly Arg Ala Pro Leu Ala Val 
    930                 935                 940                 


Met Glu Gly Val Phe Lys Asp Glu Ser Asp Thr Arg Arg Leu Asn Ser 
945                 950                 955                 960 


Ser Val Val Asp Thr Gln Ser Lys His Ser Ala Gln Gly Asp Arg Leu 
                965                 970                 975     


Pro Pro Leu Ser Gly Pro Phe Asp Asn Asn Asn Gln Ile Ala Tyr Val 
            980                 985                 990         


Asp Gln Ser Asp Ser Val Asp Ser  Ser Pro Val Lys Glu  Val Lys Ala 
        995                 1000                 1005             


Pro Ser  His Pro Gly Ser Leu  Ala Lys Lys Pro Glu  Ser Thr Thr 
    1010                 1015                 1020             


Lys Arg  Ser Pro Ser Ser Lys  Gly Thr Ser Glu Pro  Glu Lys Ser 
    1025                 1030                 1035             


Leu Arg  Lys Gly Arg Pro Ala  Leu Ala Ser Gln Glu  Ser Ser Leu 
    1040                 1045                 1050             


Ser Ser  Thr Ser Pro Ser Ser  Pro Leu Pro Val Lys  Val Ser Leu 
    1055                 1060                 1065             


Lys Pro  Ser Arg Ser Arg Ser  Lys Ala Asp Ser Ser  Ser Arg Gly 
    1070                 1075                 1080             


Ser Gly  Arg His Ser Ser Pro  Ala Pro Ala Gln Pro  Lys Lys Glu 
    1085                 1090                 1095             


Ser Ser  Pro Lys Ser Gln Asp  Ser Val Ser Ser Pro  Ser Pro Gln 
    1100                 1105                 1110             


Lys Gln  Lys Ser Ala Ser Ala  Leu Thr Tyr Thr Ala  Ser Ser Thr 
    1115                 1120                 1125             


Ser Ala  Lys Lys Ala Ser Gly  Pro Ala Thr Arg Ser  Pro Phe Pro 
    1130                 1135                 1140             


Pro Gly  Lys Ser Arg Thr Ser  Asp His Ser Leu Ser  Arg Glu Gly 
    1145                 1150                 1155             


Ser Arg  Gln Ser Leu Gly Ser  Asp Arg Ala Ser Ala  Thr Ser Thr 
    1160                 1165                 1170             


Ser Lys  Pro Asn Ser Pro Arg  Val Ser Gln Ala Arg  Ala Gly Glu 
    1175                 1180                 1185             


Gly Arg  Gly Ala Gly Lys His  Val Arg Ser Ser Ser  Met Ala Ser 
    1190                 1195                 1200             


Leu Arg  Ser Pro Ser Thr Ser  Ile Lys Ser Gly Leu  Lys Arg Asp 
    1205                 1210                 1215             


Ser Lys  Ser Glu Asp Lys Gly  Leu Ser Phe Phe Lys  Ser Ala Leu 
    1220                 1225                 1230             


Arg Gln  Lys Glu Thr Arg Arg  Ser Thr Asp Leu Gly  Lys Thr Ala 
    1235                 1240                 1245             


Leu Leu  Ser Lys Lys Ala Gly  Gly Ser Ser Val Lys  Ser Val Cys 
    1250                 1255                 1260             


Lys Asn  Thr Gly Asp Asp Glu  Ala Glu Arg Gly His  Gln Pro Pro 
    1265                 1270                 1275             


Ala Ser  Gln Gln Pro Asn Ala  Asn Thr Thr Gly Lys  Glu Gln Leu 
    1280                 1285                 1290             


Val Thr  Lys Asp Pro Ala Ser  Ala Lys His Ser Leu  Leu Ser Ala 
    1295                 1300                 1305             


Arg Lys  Ser Lys Ser Ser Gln  Leu Asp Ser Gly Val  Pro Ser Ser 
    1310                 1315                 1320             


Pro Gly  Gly Arg Gln Ser Ala  Glu Lys Ser Ser Lys  Lys Leu Ser 
    1325                 1330                 1335             


Ser Ser  Met Gln Thr Ser Ala  Arg Pro Ser Gln Lys  Pro Gln 
    1340                 1345                 1350         


<210> 40
<211> 530
<212> PRT
<213> Homo sapiens

<400> 40
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Lys Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 41
<211> 553
<212> PRT
<213> Homo sapiens

<400> 41
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Asp Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Lys 
    290                 295                 300                 


Leu Tyr Met Ser Gln Thr Asn Ser Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln Trp Ser Gln Trp Lys Tyr Arg Pro Thr Arg Arg Gly Ala His 
    530                 535                 540                 


Thr His Ala His Thr Gln Thr His Thr 
545                 550             


<210> 42
<211> 1375
<212> PRT
<213> Homo sapiens

<400> 42
Met Val Pro Gly Glu Glu Asn Gln Leu Val Pro Lys Glu Asp Val Phe 
1               5                   10                  15      


Trp Arg Cys Arg Gln Asn Ile Phe Asp Glu Met Lys Lys Lys Phe Leu 
            20                  25                  30          


Gln Ile Glu Asn Ala Ala Glu Glu Pro Arg Val Leu Cys Ile Ile Gln 
        35                  40                  45              


Asp Thr Thr Asn Ser Lys Thr Val Asn Glu Arg Ile Thr Leu Asn Leu 
    50                  55                  60                  


Pro Ala Ser Thr Pro Val Arg Lys Leu Phe Glu Asp Val Ala Asn Lys 
65                  70                  75                  80  


Val Gly Tyr Ile Asn Gly Thr Phe Asp Leu Val Trp Gly Asn Gly Ile 
                85                  90                  95      


Asn Thr Ala Asp Met Ala Pro Leu Asp His Thr Ser Asp Lys Ser Leu 
            100                 105                 110         


Leu Asp Ala Asn Phe Glu Pro Gly Lys Lys Asn Phe Leu His Leu Thr 
        115                 120                 125             


Asp Lys Asp Gly Glu Gln Pro Gln Ile Leu Leu Glu Asp Ser Ser Ala 
    130                 135                 140                 


Gly Glu Asp Ser Val His Asp Arg Phe Ile Gly Pro Leu Pro Arg Glu 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Thr Ser Asp Tyr Val Ser Gln Ser Tyr Ser Tyr 
                165                 170                 175     


Ser Ser Ile Leu Asn Lys Ser Glu Thr Gly Tyr Val Gly Leu Val Asn 
            180                 185                 190         


Gln Ala Met Thr Cys Tyr Leu Asn Ser Leu Leu Gln Thr Leu Phe Met 
        195                 200                 205             


Thr Pro Glu Phe Arg Asn Ala Leu Tyr Lys Trp Glu Phe Glu Glu Ser 
    210                 215                 220                 


Glu Glu Asp Pro Val Thr Ser Ile Pro Tyr Gln Leu Gln Arg Leu Phe 
225                 230                 235                 240 


Val Leu Leu Gln Thr Ser Lys Lys Arg Ala Ile Glu Thr Thr Asp Val 
                245                 250                 255     


Thr Arg Ser Phe Gly Trp Asp Ser Ser Glu Ala Trp Gln Gln His Asp 
            260                 265                 270         


Val Gln Glu Leu Cys Arg Val Met Phe Asp Ala Leu Glu Gln Lys Trp 
        275                 280                 285             


Lys Gln Thr Glu Gln Ala Asp Leu Ile Asn Glu Leu Tyr Gln Gly Lys 
    290                 295                 300                 


Leu Lys Asp Tyr Val Arg Cys Leu Glu Cys Gly Tyr Glu Gly Trp Arg 
305                 310                 315                 320 


Ile Asp Thr Tyr Leu Asp Ile Pro Leu Val Ile Arg Pro Tyr Gly Ser 
                325                 330                 335     


Ser Gln Ala Phe Ala Ser Val Glu Glu Ala Leu His Ala Phe Ile Gln 
            340                 345                 350         


Pro Glu Ile Leu Asp Gly Pro Asn Gln Tyr Phe Cys Glu Arg Cys Lys 
        355                 360                 365             


Lys Lys Cys Asp Ala Arg Lys Gly Leu Arg Phe Leu His Phe Pro Tyr 
    370                 375                 380                 


Leu Leu Thr Leu Gln Leu Lys Arg Phe Asp Phe Asp Tyr Thr Thr Met 
385                 390                 395                 400 


His Arg Ile Lys Leu Asn Asp Arg Met Thr Phe Pro Glu Glu Leu Asp 
                405                 410                 415     


Met Ser Thr Phe Ile Asp Val Glu Asp Glu Lys Ser Pro Gln Thr Glu 
            420                 425                 430         


Ser Cys Thr Asp Ser Gly Ala Glu Asn Glu Gly Ser Cys His Ser Asp 
        435                 440                 445             


Gln Met Ser Asn Asp Phe Ser Asn Asp Asp Gly Val Asp Glu Gly Ile 
    450                 455                 460                 


Cys Leu Glu Thr Asn Ser Gly Thr Glu Lys Ile Ser Lys Ser Gly Leu 
465                 470                 475                 480 


Glu Lys Asn Ser Leu Ile Tyr Glu Leu Phe Ser Val Met Val His Ser 
                485                 490                 495     


Gly Ser Ala Ala Gly Gly His Tyr Tyr Ala Cys Ile Lys Ser Phe Ser 
            500                 505                 510         


Asp Glu Gln Trp Tyr Ser Phe Asn Asp Gln His Val Ser Arg Ile Thr 
        515                 520                 525             


Gln Glu Asp Ile Lys Lys Thr His Gly Gly Ser Ser Gly Ser Arg Gly 
    530                 535                 540                 


Tyr Tyr Ser Ser Ala Phe Ala Ser Ser Thr Asn Ala Tyr Met Leu Ile 
545                 550                 555                 560 


Tyr Arg Leu Lys Asp Pro Ala Arg Asn Ala Lys Phe Leu Glu Val Asp 
                565                 570                 575     


Glu Tyr Pro Glu His Ile Lys Asn Leu Val Gln Lys Glu Arg Glu Leu 
            580                 585                 590         


Glu Glu Gln Glu Lys Arg Gln Arg Glu Ile Glu Arg Asn Thr Cys Lys 
        595                 600                 605             


Ile Lys Leu Phe Cys Leu His Pro Thr Lys Gln Val Met Met Glu Asn 
    610                 615                 620                 


Lys Leu Glu Val His Lys Asp Lys Thr Leu Lys Glu Ala Val Glu Met 
625                 630                 635                 640 


Ala Tyr Lys Met Met Asp Leu Glu Glu Val Ile Pro Leu Asp Cys Cys 
                645                 650                 655     


Arg Leu Val Lys Tyr Asp Glu Phe His Asp Tyr Leu Glu Arg Ser Tyr 
            660                 665                 670         


Glu Gly Glu Glu Asp Thr Pro Met Gly Leu Leu Leu Gly Gly Val Lys 
        675                 680                 685             


Ser Thr Tyr Met Phe Asp Leu Leu Leu Glu Thr Arg Lys Pro Asp Gln 
    690                 695                 700                 


Val Phe Gln Ser Tyr Lys Pro Gly Glu Val Met Val Lys Val His Val 
705                 710                 715                 720 


Val Asp Leu Lys Ala Glu Ser Val Ala Ala Pro Ile Thr Val Arg Ala 
                725                 730                 735     


Tyr Leu Asn Gln Thr Val Thr Glu Phe Lys Gln Leu Ile Ser Lys Ala 
            740                 745                 750         


Ile His Leu Pro Ala Glu Thr Met Arg Ile Val Leu Glu Arg Cys Tyr 
        755                 760                 765             


Asn Asp Leu Arg Leu Leu Ser Val Ser Ser Lys Thr Leu Lys Ala Glu 
    770                 775                 780                 


Gly Phe Phe Arg Ser Asn Lys Val Phe Val Glu Ser Ser Glu Thr Leu 
785                 790                 795                 800 


Asp Tyr Gln Met Ala Phe Ala Asp Ser His Leu Trp Lys Leu Leu Asp 
                805                 810                 815     


Arg His Ala Asn Thr Ile Arg Leu Phe Val Leu Leu Pro Glu Gln Ser 
            820                 825                 830         


Pro Val Ser Tyr Ser Lys Arg Thr Ala Tyr Gln Lys Ala Gly Gly Asp 
        835                 840                 845             


Ser Gly Asn Val Asp Asp Asp Cys Glu Arg Val Lys Gly Pro Val Gly 
    850                 855                 860                 


Ser Leu Lys Ser Val Glu Ala Ile Leu Glu Glu Ser Thr Glu Lys Leu 
865                 870                 875                 880 


Lys Ser Leu Ser Leu Gln Gln Gln Gln Asp Gly Asp Asn Gly Asp Ser 
                885                 890                 895     


Ser Lys Ser Thr Glu Thr Ser Asp Phe Glu Asn Ile Glu Ser Pro Leu 
            900                 905                 910         


Asn Glu Arg Asp Ser Ser Ala Ser Val Asp Asn Arg Glu Leu Glu Gln 
        915                 920                 925             


His Ile Gln Thr Ser Asp Pro Glu Asn Phe Gln Ser Glu Glu Arg Ser 
    930                 935                 940                 


Asp Ser Asp Val Asn Asn Asp Arg Ser Thr Ser Ser Val Asp Ser Asp 
945                 950                 955                 960 


Ile Leu Ser Ser Ser His Ser Ser Asp Thr Leu Cys Asn Ala Asp Asn 
                965                 970                 975     


Ala Gln Ile Pro Leu Ala Asn Gly Leu Asp Ser His Ser Ile Thr Ser 
            980                 985                 990         


Ser Arg Arg Thr Lys Ala Asn Glu  Gly Lys Lys Glu Thr  Trp Asp Thr 
        995                 1000                 1005             


Ala Glu  Glu Asp Ser Gly Thr  Asp Ser Glu Tyr Asp  Glu Ser Gly 
    1010                 1015                 1020             


Lys Ser  Arg Gly Glu Met Gln  Tyr Met Tyr Phe Lys  Ala Glu Pro 
    1025                 1030                 1035             


Tyr Ala  Ala Asp Glu Gly Ser  Gly Glu Gly His Lys  Trp Leu Met 
    1040                 1045                 1050             


Val His  Val Asp Lys Arg Ile  Thr Leu Ala Ala Phe  Lys Gln His 
    1055                 1060                 1065             


Leu Glu  Pro Phe Val Gly Val  Leu Ser Ser His Phe  Lys Val Phe 
    1070                 1075                 1080             


Arg Val  Tyr Ala Ser Asn Gln  Glu Phe Glu Ser Val  Arg Leu Asn 
    1085                 1090                 1095             


Glu Thr  Leu Ser Ser Phe Ser  Asp Asp Asn Lys Ile  Thr Ile Arg 
    1100                 1105                 1110             


Leu Gly  Arg Ala Leu Lys Lys  Gly Glu Tyr Arg Val  Lys Val Tyr 
    1115                 1120                 1125             


Gln Leu  Leu Val Asn Glu Gln  Glu Pro Cys Lys Phe  Leu Leu Asp 
    1130                 1135                 1140             


Ala Val  Phe Ala Lys Gly Met  Thr Val Arg Gln Ser  Lys Glu Glu 
    1145                 1150                 1155             


Leu Ile  Pro Gln Leu Arg Glu  Gln Cys Gly Leu Glu  Leu Ser Ile 
    1160                 1165                 1170             


Asp Arg  Phe Arg Leu Arg Lys  Lys Thr Trp Lys Asn  Pro Gly Thr 
    1175                 1180                 1185             


Val Phe  Leu Asp Tyr His Ile  Tyr Glu Glu Asp Ile  Asn Ile Ser 
    1190                 1195                 1200             


Ser Asn  Trp Glu Val Phe Leu  Glu Val Leu Asp Gly  Val Glu Lys 
    1205                 1210                 1215             


Met Lys  Ser Met Ser Gln Leu  Ala Val Leu Ser Arg  Arg Trp Lys 
    1220                 1225                 1230             


Pro Ser  Glu Met Lys Leu Asp  Pro Phe Gln Glu Val  Val Leu Glu 
    1235                 1240                 1245             


Ser Ser  Ser Val Asp Glu Leu  Arg Glu Lys Leu Ser  Glu Ile Ser 
    1250                 1255                 1260             


Gly Ile  Pro Leu Asp Asp Ile  Glu Phe Ala Lys Gly  Arg Gly Thr 
    1265                 1270                 1275             


Phe Pro  Cys Asp Ile Ser Val  Leu Asp Ile His Gln  Asp Leu Asp 
    1280                 1285                 1290             


Trp Asn  Pro Lys Val Ser Thr  Leu Asn Val Trp Pro  Leu Tyr Ile 
    1295                 1300                 1305             


Cys Asp  Asp Gly Ala Val Ile  Phe Tyr Arg Asp Lys  Thr Glu Glu 
    1310                 1315                 1320             


Leu Met  Glu Leu Thr Asp Glu  Gln Arg Asn Glu Leu  Met Lys Lys 
    1325                 1330                 1335             


Glu Ser  Ser Arg Leu Gln Lys  Thr Gly His Arg Val  Thr Tyr Ser 
    1340                 1345                 1350             


Pro Arg  Lys Glu Lys Ala Leu  Lys Ile Tyr Leu Asp  Gly Ala Pro 
    1355                 1360                 1365             


Asn Lys  Asp Leu Thr Gln Asp  
    1370                 1375 


<210> 43
<211> 711
<212> PRT
<213> Homo sapiens

<400> 43
Met Ala Gln Val Arg Glu Thr Ser Leu Pro Ser Gly Ser Gly Val Arg 
1               5                   10                  15      


Trp Ile Ser Gly Gly Gly Gly Gly Ala Ser Pro Glu Glu Ala Val Glu 
            20                  25                  30          


Lys Ala Gly Lys Met Glu Glu Ala Ala Ala Gly Ala Thr Lys Ala Ser 
        35                  40                  45              


Ser Arg Arg Glu Ala Glu Glu Met Lys Leu Glu Pro Leu Gln Glu Arg 
    50                  55                  60                  


Glu Pro Ala Pro Glu Glu Asn Leu Thr Trp Ser Ser Ser Gly Gly Asp 
65                  70                  75                  80  


Glu Lys Val Leu Pro Ser Ile Pro Leu Arg Cys His Ser Ser Ser Ser 
                85                  90                  95      


Pro Val Cys Pro Arg Arg Lys Pro Arg Pro Arg Pro Gln Pro Arg Ala 
            100                 105                 110         


Arg Ser Arg Ser Gln Pro Gly Leu Ser Ala Pro Pro Pro Pro Pro Ala 
        115                 120                 125             


Arg Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Arg Pro 
    130                 135                 140                 


Arg Ala Trp Arg Gly Ser Arg Arg Arg Ser Arg Pro Gly Ser Arg Pro 
145                 150                 155                 160 


Gln Thr Arg Arg Ser Cys Ser Gly Asp Leu Asp Gly Ser Gly Asp Pro 
                165                 170                 175     


Gly Gly Leu Gly Asp Trp Leu Leu Glu Val Glu Phe Gly Gln Gly Pro 
            180                 185                 190         


Thr Gly Cys Ser His Val Glu Ser Phe Lys Val Gly Lys Asn Trp Gln 
        195                 200                 205             


Lys Asn Leu Arg Leu Ile Tyr Gln Arg Phe Val Trp Ser Gly Thr Pro 
    210                 215                 220                 


Glu Thr Arg Lys Arg Lys Ala Lys Ser Cys Ile Cys His Val Cys Ser 
225                 230                 235                 240 


Thr His Met Asn Arg Leu His Ser Cys Leu Ser Cys Val Phe Phe Gly 
                245                 250                 255     


Cys Phe Thr Glu Lys His Ile His Lys His Ala Glu Thr Lys Gln His 
            260                 265                 270         


His Leu Ala Val Asp Leu Tyr His Gly Val Ile Tyr Cys Phe Met Cys 
        275                 280                 285             


Lys Asp Tyr Val Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys Glu Thr 
    290                 295                 300                 


Lys Glu Lys Ile Leu Arg Leu Leu Thr Ser Thr Ser Thr Asp Val Ser 
305                 310                 315                 320 


His Gln Gln Phe Met Thr Ser Gly Phe Glu Asp Lys Gln Ser Thr Cys 
                325                 330                 335     


Glu Thr Lys Glu Gln Glu Pro Lys Leu Val Lys Pro Lys Lys Lys Arg 
            340                 345                 350         


Arg Lys Lys Ser Val Tyr Thr Val Gly Leu Arg Gly Leu Ile Asn Leu 
        355                 360                 365             


Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His Ile 
    370                 375                 380                 


Pro Leu Leu Lys Asp Phe Phe Leu Ser Asp Lys His Lys Cys Ile Met 
385                 390                 395                 400 


Thr Ser Pro Ser Leu Cys Leu Val Cys Glu Met Ser Ser Leu Phe His 
                405                 410                 415     


Ala Met Tyr Ser Gly Ser Arg Thr Pro His Ile Pro Tyr Lys Leu Leu 
            420                 425                 430         


His Leu Ile Trp Ile His Ala Glu His Leu Ala Gly Tyr Arg Gln Gln 
        435                 440                 445             


Asp Ala His Glu Phe Leu Ile Ala Ile Leu Asp Val Leu His Arg His 
    450                 455                 460                 


Ser Lys Asp Asp Ser Gly Gly Gln Glu Ala Asn Asn Pro Asn Cys Cys 
465                 470                 475                 480 


Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val 
                485                 490                 495     


Thr Cys Gln Ala Cys His Ser Val Ser Thr Thr Ile Asp Pro Cys Trp 
            500                 505                 510         


Asp Ile Ser Leu Asp Leu Pro Gly Ser Cys Ala Thr Phe Asp Ser Gln 
        515                 520                 525             


Asn Pro Glu Arg Ala Asp Ser Thr Val Ser Arg Asp Asp His Ile Pro 
    530                 535                 540                 


Gly Ile Pro Ser Leu Thr Asp Cys Leu Gln Trp Phe Thr Arg Pro Glu 
545                 550                 555                 560 


His Leu Gly Ser Ser Ala Lys Ile Lys Cys Asn Ser Cys Gln Ser Tyr 
                565                 570                 575     


Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro Ile Val Ala 
            580                 585                 590         


Cys Phe His Leu Lys Arg Phe Glu His Val Gly Lys Gln Arg Arg Lys 
        595                 600                 605             


Ile Asn Thr Phe Ile Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe 
    610                 615                 620                 


Leu Ala Ser Thr Lys Glu Ser Arg Met Lys Glu Gly Gln Pro Pro Thr 
625                 630                 635                 640 


Asp Cys Val Pro Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val Ile Asn 
                645                 650                 655     


His His Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile Arg Gln 
            660                 665                 670         


Gln Lys Asp Gln Trp Phe Ser Cys Asp Asp Ala Ile Ile Thr Lys Ala 
        675                 680                 685             


Thr Ile Glu Asp Leu Leu Tyr Ser Glu Gly Tyr Leu Leu Phe Tyr His 
    690                 695                 700                 


Lys Gln Gly Leu Glu Lys Asp 
705                 710     


<210> 44
<211> 1123
<212> PRT
<213> Homo sapiens

<400> 44
Met Pro Ile Val Asp Lys Leu Lys Glu Ala Leu Lys Pro Gly Arg Lys 
1               5                   10                  15      


Asp Ser Ala Asp Asp Gly Glu Leu Gly Lys Leu Leu Ala Ser Ser Ala 
            20                  25                  30          


Lys Lys Val Leu Leu Gln Lys Ile Glu Phe Glu Pro Ala Ser Lys Ser 
        35                  40                  45              


Phe Ser Tyr Gln Leu Glu Ala Leu Lys Ser Lys Tyr Val Leu Leu Asn 
    50                  55                  60                  


Pro Lys Thr Glu Gly Ala Ser Arg His Lys Ser Gly Asp Asp Pro Pro 
65                  70                  75                  80  


Ala Arg Arg Gln Gly Ser Glu His Thr Tyr Glu Ser Cys Gly Asp Gly 
                85                  90                  95      


Val Pro Ala Pro Gln Lys Val Leu Phe Pro Thr Glu Arg Leu Ser Leu 
            100                 105                 110         


Arg Trp Glu Arg Val Phe Arg Val Gly Ala Gly Leu His Asn Leu Gly 
        115                 120                 125             


Asn Thr Cys Phe Leu Asn Ala Thr Ile Gln Cys Leu Thr Tyr Thr Pro 
    130                 135                 140                 


Pro Leu Ala Asn Tyr Leu Leu Ser Lys Glu His Ala Arg Ser Cys His 
145                 150                 155                 160 


Gln Gly Ser Phe Cys Met Leu Cys Val Met Gln Asn His Ile Val Gln 
                165                 170                 175     


Ala Phe Ala Asn Ser Gly Asn Ala Ile Lys Pro Val Ser Phe Ile Arg 
            180                 185                 190         


Asp Leu Lys Lys Ile Ala Arg His Phe Arg Phe Gly Asn Gln Glu Asp 
        195                 200                 205             


Ala His Glu Phe Leu Arg Tyr Thr Ile Asp Ala Met Gln Lys Ala Cys 
    210                 215                 220                 


Leu Asn Gly Cys Ala Lys Leu Asp Arg Gln Thr Gln Ala Thr Thr Leu 
225                 230                 235                 240 


Val His Gln Ile Phe Gly Gly Tyr Leu Arg Ser Arg Val Lys Cys Ser 
                245                 250                 255     


Val Cys Lys Ser Val Ser Asp Thr Tyr Asp Pro Tyr Leu Asp Val Ala 
            260                 265                 270         


Leu Glu Ile Arg Gln Ala Ala Asn Ile Val Arg Ala Leu Glu Leu Phe 
        275                 280                 285             


Val Lys Ala Asp Val Leu Ser Gly Glu Asn Ala Tyr Met Cys Ala Lys 
    290                 295                 300                 


Cys Lys Lys Lys Val Pro Ala Ser Lys Arg Phe Thr Ile His Arg Thr 
305                 310                 315                 320 


Ser Asn Val Leu Thr Leu Ser Leu Lys Arg Phe Ala Asn Phe Ser Gly 
                325                 330                 335     


Gly Lys Ile Thr Lys Asp Val Gly Tyr Pro Glu Phe Leu Asn Ile Arg 
            340                 345                 350         


Pro Tyr Met Ser Gln Asn Asn Gly Asp Pro Val Met Tyr Gly Leu Tyr 
        355                 360                 365             


Ala Val Leu Val His Ser Gly Tyr Ser Cys His Ala Gly His Tyr Tyr 
    370                 375                 380                 


Cys Tyr Val Lys Ala Ser Asn Gly Gln Trp Tyr Gln Met Asn Asp Ser 
385                 390                 395                 400 


Leu Val His Ser Ser Asn Val Lys Val Val Leu Asn Gln Gln Ala Tyr 
                405                 410                 415     


Val Leu Phe Tyr Leu Arg Ile Pro Gly Ser Lys Lys Ser Pro Glu Gly 
            420                 425                 430         


Leu Ile Ser Arg Thr Gly Ser Ser Ser Leu Pro Gly Arg Pro Ser Val 
        435                 440                 445             


Ile Pro Asp His Ser Lys Lys Asn Ile Gly Asn Gly Ile Ile Ser Ser 
    450                 455                 460                 


Pro Leu Thr Gly Lys Arg Gln Asp Ser Gly Thr Met Lys Lys Pro His 
465                 470                 475                 480 


Thr Thr Glu Glu Ile Gly Val Pro Ile Ser Arg Asn Gly Ser Thr Leu 
                485                 490                 495     


Gly Leu Lys Ser Gln Asn Gly Cys Ile Pro Pro Lys Leu Pro Ser Gly 
            500                 505                 510         


Ser Pro Ser Pro Lys Leu Ser Gln Thr Pro Thr His Met Pro Thr Ile 
        515                 520                 525             


Leu Asp Asp Pro Gly Lys Lys Val Lys Lys Pro Ala Pro Pro Gln His 
    530                 535                 540                 


Phe Ser Pro Arg Thr Ala Gln Gly Leu Pro Gly Thr Ser Asn Ser Asn 
545                 550                 555                 560 


Ser Ser Arg Ser Gly Ser Gln Arg Gln Gly Ser Trp Asp Ser Arg Asp 
                565                 570                 575     


Val Val Leu Ser Thr Ser Pro Lys Leu Leu Ala Thr Ala Thr Ala Asn 
            580                 585                 590         


Gly His Gly Leu Lys Gly Asn Asp Glu Ser Ala Gly Leu Asp Arg Arg 
        595                 600                 605             


Gly Ser Ser Ser Ser Ser Pro Glu His Ser Ala Ser Ser Asp Ser Thr 
    610                 615                 620                 


Lys Ala Pro Gln Thr Pro Arg Ser Gly Ala Ala His Leu Cys Asp Ser 
625                 630                 635                 640 


Gln Glu Thr Asn Cys Ser Thr Ala Gly His Ser Lys Thr Pro Pro Ser 
                645                 650                 655     


Gly Ala Asp Ser Lys Thr Val Lys Leu Lys Ser Pro Val Leu Ser Asn 
            660                 665                 670         


Thr Thr Thr Glu Pro Ala Ser Thr Met Ser Pro Pro Pro Ala Lys Lys 
        675                 680                 685             


Leu Ala Leu Ser Ala Lys Lys Ala Ser Thr Leu Trp Arg Ala Thr Gly 
    690                 695                 700                 


Asn Asp Leu Arg Pro Pro Pro Pro Ser Pro Ser Ser Asp Leu Thr His 
705                 710                 715                 720 


Pro Met Lys Thr Ser His Pro Val Val Ala Ser Thr Trp Pro Val His 
                725                 730                 735     


Arg Ala Arg Ala Val Ser Pro Ala Pro Gln Ser Ser Ser Arg Leu Gln 
            740                 745                 750         


Pro Pro Phe Ser Pro His Pro Thr Leu Leu Ser Ser Thr Pro Lys Pro 
        755                 760                 765             


Pro Gly Thr Ser Glu Pro Arg Ser Cys Ser Ser Ile Ser Thr Ala Leu 
    770                 775                 780                 


Pro Gln Val Asn Glu Asp Leu Val Ser Leu Pro His Gln Leu Pro Glu 
785                 790                 795                 800 


Ala Ser Glu Pro Pro Gln Ser Pro Ser Glu Lys Arg Lys Lys Thr Phe 
                805                 810                 815     


Val Gly Glu Pro Gln Arg Leu Gly Ser Glu Thr Arg Leu Pro Gln His 
            820                 825                 830         


Ile Arg Glu Ala Thr Ala Ala Pro His Gly Lys Arg Lys Arg Lys Lys 
        835                 840                 845             


Lys Lys Arg Pro Glu Asp Thr Ala Ala Ser Ala Leu Gln Glu Gly Gln 
    850                 855                 860                 


Thr Gln Arg Gln Pro Gly Ser Pro Met Tyr Arg Arg Glu Gly Gln Ala 
865                 870                 875                 880 


Gln Leu Pro Ala Val Arg Arg Gln Glu Asp Gly Thr Gln Pro Gln Val 
                885                 890                 895     


Asn Gly Gln Gln Val Gly Cys Val Thr Asp Gly His His Ala Ser Ser 
            900                 905                 910         


Arg Lys Arg Arg Arg Lys Gly Ala Glu Gly Leu Gly Glu Glu Gly Gly 
        915                 920                 925             


Leu His Gln Asp Pro Leu Arg His Ser Cys Ser Pro Met Gly Asp Gly 
    930                 935                 940                 


Asp Pro Glu Ala Met Glu Glu Ser Pro Arg Lys Lys Lys Lys Lys Lys 
945                 950                 955                 960 


Arg Lys Gln Glu Thr Gln Arg Ala Val Glu Glu Asp Gly His Leu Lys 
                965                 970                 975     


Cys Pro Arg Ser Ala Lys Pro Gln Asp Ala Val Val Pro Glu Ser Ser 
            980                 985                 990         


Ser Cys Ala Pro Ser Ala Asn Gly  Trp Cys Pro Gly Asp  Arg Met Gly 
        995                 1000                 1005             


Leu Ser  Gln Ala Pro Pro Val  Ser Trp Asn Gly Glu  Arg Glu Ser 
    1010                 1015                 1020             


Asp Val  Val Gln Glu Leu Leu  Lys Tyr Ser Ser Asp  Lys Ala Tyr 
    1025                 1030                 1035             


Gly Arg  Lys Val Leu Thr Trp  Asp Gly Lys Met Ser  Ala Val Ser 
    1040                 1045                 1050             


Gln Asp  Ala Ile Glu Asp Ser  Arg Gln Ala Arg Thr  Glu Thr Val 
    1055                 1060                 1065             


Val Asp  Asp Trp Asp Glu Glu  Phe Asp Arg Gly Lys  Glu Lys Lys 
    1070                 1075                 1080             


Ile Lys  Lys Phe Lys Arg Glu  Lys Arg Arg Asn Phe  Asn Ala Phe 
    1085                 1090                 1095             


Gln Lys  Leu Gln Thr Arg Arg  Asn Phe Trp Ser Val  Thr His Pro 
    1100                 1105                 1110             


Ala Lys  Ala Ala Ser Leu Ser  Tyr Arg Arg 
    1115                 1120             


<210> 45
<211> 712
<212> PRT
<213> Homo sapiens

<400> 45
Met Leu Ala Met Asp Thr Cys Lys His Val Gly Gln Leu Gln Leu Ala 
1               5                   10                  15      


Gln Asp His Ser Ser Leu Asn Pro Gln Lys Trp His Cys Val Asp Cys 
            20                  25                  30          


Asn Thr Thr Glu Ser Ile Trp Ala Cys Leu Ser Cys Ser His Val Ala 
        35                  40                  45              


Cys Gly Arg Tyr Ile Glu Glu His Ala Leu Lys His Phe Gln Glu Ser 
    50                  55                  60                  


Ser His Pro Val Ala Leu Glu Val Asn Glu Met Tyr Val Phe Cys Tyr 
65                  70                  75                  80  


Leu Cys Asp Asp Tyr Val Leu Asn Asp Asn Thr Thr Gly Asp Leu Lys 
                85                  90                  95      


Leu Leu Arg Arg Thr Leu Ser Ala Ile Lys Ser Gln Asn Tyr His Cys 
            100                 105                 110         


Thr Thr Arg Ser Gly Arg Phe Leu Arg Ser Met Gly Thr Gly Asp Asp 
        115                 120                 125             


Ser Tyr Phe Leu His Asp Gly Ala Gln Ser Leu Leu Gln Ser Glu Asp 
    130                 135                 140                 


Gln Leu Tyr Thr Ala Leu Trp His Arg Arg Arg Ile Leu Met Gly Lys 
145                 150                 155                 160 


Ile Phe Arg Thr Trp Phe Glu Gln Ser Pro Ile Gly Arg Lys Lys Gln 
                165                 170                 175     


Glu Glu Pro Phe Gln Glu Lys Ile Val Val Lys Arg Glu Val Lys Lys 
            180                 185                 190         


Arg Arg Gln Glu Leu Glu Tyr Gln Val Lys Ala Glu Leu Glu Ser Met 
        195                 200                 205             


Pro Pro Arg Lys Ser Leu Arg Leu Gln Gly Leu Ala Gln Ser Thr Ile 
    210                 215                 220                 


Ile Glu Ile Val Ser Val Gln Val Pro Ala Gln Thr Pro Ala Ser Pro 
225                 230                 235                 240 


Ala Lys Asp Lys Val Leu Ser Thr Ser Glu Asn Glu Ile Ser Gln Lys 
                245                 250                 255     


Val Ser Asp Ser Ser Val Lys Arg Arg Pro Ile Val Thr Pro Gly Val 
            260                 265                 270         


Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Val Leu 
        275                 280                 285             


Gln Val Leu Ser His Leu Leu Ile Phe Arg Gln Cys Phe Leu Lys Leu 
    290                 295                 300                 


Asp Leu Asn Gln Trp Leu Ala Met Thr Ala Ser Glu Lys Thr Arg Ser 
305                 310                 315                 320 


Cys Lys His Pro Pro Val Thr Asp Thr Val Val Tyr Gln Met Asn Glu 
                325                 330                 335     


Cys Gln Glu Lys Asp Thr Gly Phe Val Cys Ser Arg Gln Ser Ser Leu 
            340                 345                 350         


Ser Ser Gly Leu Ser Gly Gly Ala Ser Lys Gly Arg Lys Met Glu Leu 
        355                 360                 365             


Ile Gln Pro Lys Glu Pro Thr Ser Gln Tyr Ile Ser Leu Cys His Glu 
    370                 375                 380                 


Leu His Thr Leu Phe Gln Val Met Trp Ser Gly Lys Trp Ala Leu Val 
385                 390                 395                 400 


Ser Pro Phe Ala Met Leu His Ser Val Trp Arg Leu Ile Pro Ala Phe 
                405                 410                 415     


Arg Gly Tyr Ala Gln Gln Asp Ala Gln Glu Phe Leu Cys Glu Leu Leu 
            420                 425                 430         


Asp Lys Ile Gln Arg Glu Leu Glu Thr Thr Gly Thr Ser Leu Pro Ala 
        435                 440                 445             


Leu Ile Pro Thr Ser Gln Arg Lys Leu Ile Lys Gln Val Leu Asn Val 
    450                 455                 460                 


Val Asn Asn Ile Phe His Gly Gln Leu Leu Ser Gln Val Thr Cys Leu 
465                 470                 475                 480 


Ala Cys Asp Asn Lys Ser Asn Thr Ile Glu Pro Phe Trp Asp Leu Ser 
                485                 490                 495     


Leu Glu Phe Pro Glu Arg Tyr Gln Cys Ser Gly Lys Asp Ile Ala Ser 
            500                 505                 510         


Gln Pro Cys Leu Val Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu 
        515                 520                 525             


Ala Leu Glu Gly Lys Ile Tyr Val Cys Asp Gln Cys Asn Ser Lys Arg 
    530                 535                 540                 


Arg Arg Phe Ser Ser Lys Pro Val Val Leu Thr Glu Ala Gln Lys Gln 
545                 550                 555                 560 


Leu Met Ile Cys His Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg 
                565                 570                 575     


Phe Arg Trp Ser Gly Arg Asn Asn Arg Glu Lys Ile Gly Val His Val 
            580                 585                 590         


Gly Phe Glu Glu Ile Leu Asn Met Glu Pro Tyr Cys Cys Arg Glu Thr 
        595                 600                 605             


Leu Lys Ser Leu Arg Pro Glu Cys Phe Ile Tyr Asp Leu Ser Ala Val 
    610                 615                 620                 


Val Met His His Gly Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr 
625                 630                 635                 640 


Cys Tyr Asn Ser Glu Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys 
                645                 650                 655     


Leu Ser Met Cys Thr Met Asp Glu Val Cys Lys Ala Gln Ala Tyr Ile 
            660                 665                 670         


Leu Phe Tyr Thr Gln Arg Val Thr Glu Asn Gly His Ser Lys Leu Leu 
        675                 680                 685             


Pro Pro Glu Leu Leu Leu Gly Ser Gln His Pro Asn Glu Asp Ala Asp 
    690                 695                 700                 


Thr Ser Ser Asn Glu Ile Leu Ser 
705                 710         


<210> 46
<211> 1118
<212> PRT
<213> Homo sapiens

<400> 46
Met Pro Ala Val Ala Ser Val Pro Lys Glu Leu Tyr Leu Ser Ser Ser 
1               5                   10                  15      


Leu Lys Asp Leu Asn Lys Lys Thr Glu Val Lys Pro Glu Lys Ile Ser 
            20                  25                  30          


Thr Lys Ser Tyr Val His Ser Ala Leu Lys Ile Phe Lys Thr Ala Glu 
        35                  40                  45              


Glu Cys Arg Leu Asp Arg Asp Glu Glu Arg Ala Tyr Val Leu Tyr Met 
    50                  55                  60                  


Lys Tyr Val Thr Val Tyr Asn Leu Ile Lys Lys Arg Pro Asp Phe Lys 
65                  70                  75                  80  


Gln Gln Gln Asp Tyr Phe His Ser Ile Leu Gly Pro Gly Asn Ile Lys 
                85                  90                  95      


Lys Ala Val Glu Glu Ala Glu Arg Leu Ser Glu Ser Leu Lys Leu Arg 
            100                 105                 110         


Tyr Glu Glu Ala Glu Val Arg Lys Lys Leu Glu Glu Lys Asp Arg Gln 
        115                 120                 125             


Glu Glu Ala Gln Arg Leu Gln Gln Lys Arg Gln Glu Thr Gly Arg Glu 
    130                 135                 140                 


Asp Gly Gly Thr Leu Ala Lys Gly Ser Leu Glu Asn Val Leu Asp Ser 
145                 150                 155                 160 


Lys Asp Lys Thr Gln Lys Ser Asn Gly Glu Lys Asn Glu Lys Cys Glu 
                165                 170                 175     


Thr Lys Glu Lys Gly Ala Ile Thr Ala Lys Glu Leu Tyr Thr Met Met 
            180                 185                 190         


Thr Asp Lys Asn Ile Ser Leu Ile Ile Met Asp Ala Arg Arg Met Gln 
        195                 200                 205             


Asp Tyr Gln Asp Ser Cys Ile Leu His Ser Leu Ser Val Pro Glu Glu 
    210                 215                 220                 


Ala Ile Ser Pro Gly Val Thr Ala Ser Trp Ile Glu Ala His Leu Pro 
225                 230                 235                 240 


Asp Asp Ser Lys Asp Thr Trp Lys Lys Arg Gly Asn Val Glu Tyr Val 
                245                 250                 255     


Val Leu Leu Asp Trp Phe Ser Ser Ala Lys Asp Leu Gln Ile Gly Thr 
            260                 265                 270         


Thr Leu Arg Ser Leu Lys Asp Ala Leu Phe Lys Trp Glu Ser Lys Thr 
        275                 280                 285             


Val Leu Arg Asn Glu Pro Leu Val Leu Glu Gly Gly Tyr Glu Asn Trp 
    290                 295                 300                 


Leu Leu Cys Tyr Pro Gln Tyr Thr Thr Asn Ala Lys Val Thr Pro Pro 
305                 310                 315                 320 


Pro Arg Arg Gln Asn Glu Glu Val Ser Ile Ser Leu Asp Phe Thr Tyr 
                325                 330                 335     


Pro Ser Leu Glu Glu Ser Ile Pro Ser Lys Pro Ala Ala Gln Thr Pro 
            340                 345                 350         


Pro Ala Ser Ile Glu Val Asp Glu Asn Ile Glu Leu Ile Ser Gly Gln 
        355                 360                 365             


Asn Glu Arg Met Gly Pro Leu Asn Ile Ser Thr Pro Val Glu Pro Val 
    370                 375                 380                 


Ala Ala Ser Lys Ser Asp Val Ser Pro Ile Ile Gln Pro Val Pro Ser 
385                 390                 395                 400 


Ile Lys Asn Val Pro Gln Ile Asp Arg Thr Lys Lys Pro Ala Val Lys 
                405                 410                 415     


Leu Pro Glu Glu His Arg Ile Lys Ser Glu Ser Thr Asn His Glu Gln 
            420                 425                 430         


Gln Ser Pro Gln Ser Gly Lys Val Ile Pro Asp Arg Ser Thr Lys Pro 
        435                 440                 445             


Val Val Phe Ser Pro Thr Leu Met Leu Thr Asp Glu Glu Lys Ala Arg 
    450                 455                 460                 


Ile His Ala Glu Thr Ala Leu Leu Met Glu Lys Asn Lys Gln Glu Lys 
465                 470                 475                 480 


Glu Leu Arg Glu Arg Gln Gln Glu Glu Gln Lys Glu Lys Leu Arg Lys 
                485                 490                 495     


Glu Glu Gln Glu Gln Lys Ala Lys Lys Lys Gln Glu Ala Glu Glu Asn 
            500                 505                 510         


Glu Ile Thr Glu Lys Gln Gln Lys Ala Lys Glu Glu Met Glu Lys Lys 
        515                 520                 525             


Glu Ser Glu Gln Ala Lys Lys Glu Asp Lys Glu Thr Ser Ala Lys Arg 
    530                 535                 540                 


Gly Lys Glu Ile Thr Gly Val Lys Arg Gln Ser Lys Ser Glu His Glu 
545                 550                 555                 560 


Thr Ser Asp Ala Lys Lys Ser Val Glu Asp Arg Gly Lys Arg Cys Pro 
                565                 570                 575     


Thr Pro Glu Ile Gln Lys Lys Ser Thr Gly Asp Val Pro His Thr Ser 
            580                 585                 590         


Val Thr Gly Asp Ser Gly Ser Gly Lys Pro Phe Lys Ile Lys Gly Gln 
        595                 600                 605             


Pro Glu Ser Gly Ile Leu Arg Thr Gly Thr Phe Arg Glu Asp Thr Asp 
    610                 615                 620                 


Asp Thr Glu Arg Asn Lys Ala Gln Arg Glu Pro Leu Thr Arg Ala Arg 
625                 630                 635                 640 


Ser Glu Glu Met Gly Arg Ile Val Pro Gly Leu Pro Ser Gly Trp Ala 
                645                 650                 655     


Lys Phe Leu Asp Pro Ile Thr Gly Thr Phe Arg Tyr Tyr His Ser Pro 
            660                 665                 670         


Thr Asn Thr Val His Met Tyr Pro Pro Glu Met Ala Pro Ser Ser Ala 
        675                 680                 685             


Pro Pro Ser Thr Pro Pro Thr His Lys Ala Lys Pro Gln Ile Pro Ala 
    690                 695                 700                 


Glu Arg Asp Arg Glu Pro Ser Lys Leu Lys Arg Ser Tyr Ser Ser Pro 
705                 710                 715                 720 


Asp Ile Thr Gln Ala Ile Gln Glu Glu Glu Lys Arg Lys Pro Thr Val 
                725                 730                 735     


Thr Pro Thr Val Asn Arg Glu Asn Lys Pro Thr Cys Tyr Pro Lys Ala 
            740                 745                 750         


Glu Ile Ser Arg Leu Ser Ala Ser Gln Ile Arg Asn Leu Asn Pro Val 
        755                 760                 765             


Phe Gly Gly Ser Gly Pro Ala Leu Thr Gly Leu Arg Asn Leu Gly Asn 
    770                 775                 780                 


Thr Cys Tyr Met Asn Ser Ile Leu Gln Cys Leu Cys Asn Ala Pro His 
785                 790                 795                 800 


Leu Ala Asp Tyr Phe Asn Arg Asn Cys Tyr Gln Asp Asp Ile Asn Arg 
                805                 810                 815     


Ser Asn Leu Leu Gly His Lys Gly Glu Val Ala Glu Glu Phe Gly Ile 
            820                 825                 830         


Ile Met Lys Ala Leu Trp Thr Gly Gln Tyr Arg Tyr Ile Ser Pro Lys 
        835                 840                 845             


Asp Phe Lys Ile Thr Ile Gly Lys Ile Asn Asp Gln Phe Ala Gly Tyr 
    850                 855                 860                 


Ser Gln Gln Asp Ser Gln Glu Leu Leu Leu Phe Leu Met Asp Gly Leu 
865                 870                 875                 880 


His Glu Asp Leu Asn Lys Ala Asp Asn Arg Lys Arg Tyr Lys Glu Glu 
                885                 890                 895     


Asn Asn Asp His Leu Asp Asp Phe Lys Ala Ala Glu His Ala Trp Gln 
            900                 905                 910         


Lys His Lys Gln Leu Asn Glu Ser Ile Ile Val Ala Leu Phe Gln Gly 
        915                 920                 925             


Gln Phe Lys Ser Thr Val Gln Cys Leu Thr Cys His Lys Lys Ser Arg 
    930                 935                 940                 


Thr Phe Glu Ala Phe Met Tyr Leu Ser Leu Pro Leu Ala Ser Thr Ser 
945                 950                 955                 960 


Lys Cys Thr Leu Gln Asp Cys Leu Arg Leu Phe Ser Lys Glu Glu Lys 
                965                 970                 975     


Leu Thr Asp Asn Asn Arg Phe Tyr Cys Ser His Cys Arg Ala Arg Arg 
            980                 985                 990         


Asp Ser Leu Lys Lys Ile Glu Ile  Trp Lys Leu Pro Pro  Val Leu Leu 
        995                 1000                 1005             


Val His  Leu Lys Arg Phe Ser  Tyr Asp Gly Arg Trp  Lys Gln Lys 
    1010                 1015                 1020             


Leu Gln  Thr Ser Val Asp Phe  Pro Leu Glu Asn Leu  Asp Leu Ser 
    1025                 1030                 1035             


Gln Tyr  Val Ile Gly Pro Lys  Asn Asn Leu Lys Lys  Tyr Asn Leu 
    1040                 1045                 1050             


Phe Ser  Val Ser Asn His Tyr  Gly Gly Leu Asp Gly  Gly His Tyr 
    1055                 1060                 1065             


Thr Ala  Tyr Cys Lys Asn Ala  Ala Arg Gln Arg Trp  Phe Lys Phe 
    1070                 1075                 1080             


Asp Asp  His Glu Val Ser Asp  Ile Ser Val Ser Ser  Val Lys Ser 
    1085                 1090                 1095             


Ser Ala  Ala Tyr Ile Leu Phe  Tyr Thr Ser Leu Gly  Pro Arg Val 
    1100                 1105                 1110             


Thr Asp  Val Ala Thr 
    1115             


<210> 47
<211> 979
<212> PRT
<213> Homo sapiens

<400> 47
Met Ser Pro Leu Lys Ile His Gly Pro Ile Arg Ile Arg Ser Met Gln 
1               5                   10                  15      


Thr Gly Ile Thr Lys Trp Lys Glu Gly Ser Phe Glu Ile Val Glu Lys 
            20                  25                  30          


Glu Asn Lys Val Ser Leu Val Val His Tyr Asn Thr Gly Gly Ile Pro 
        35                  40                  45              


Arg Ile Phe Gln Leu Ser His Asn Ile Lys Asn Val Val Leu Arg Pro 
    50                  55                  60                  


Ser Gly Ala Lys Gln Ser Arg Leu Met Leu Thr Leu Gln Asp Asn Ser 
65                  70                  75                  80  


Phe Leu Ser Ile Asp Lys Val Pro Ser Lys Asp Ala Glu Glu Met Arg 
                85                  90                  95      


Leu Phe Leu Asp Ala Val His Gln Asn Arg Leu Pro Ala Ala Met Lys 
            100                 105                 110         


Pro Ser Gln Gly Ser Gly Ser Phe Gly Ala Ile Leu Gly Ser Arg Thr 
        115                 120                 125             


Ser Gln Lys Glu Thr Ser Arg Gln Leu Ser Tyr Ser Asp Asn Gln Ala 
    130                 135                 140                 


Ser Ala Lys Arg Gly Ser Leu Glu Thr Lys Asp Asp Ile Pro Phe Arg 
145                 150                 155                 160 


Lys Val Leu Gly Asn Pro Gly Arg Gly Ser Ile Lys Thr Val Ala Gly 
                165                 170                 175     


Ser Gly Ile Ala Arg Thr Ile Pro Ser Leu Thr Ser Thr Ser Thr Pro 
            180                 185                 190         


Leu Arg Ser Gly Leu Leu Glu Asn Arg Thr Glu Lys Arg Lys Arg Met 
        195                 200                 205             


Ile Ser Thr Gly Ser Glu Leu Asn Glu Asp Tyr Pro Lys Glu Asn Asp 
    210                 215                 220                 


Ser Ser Ser Asn Asn Lys Ala Met Thr Asp Pro Ser Arg Lys Tyr Leu 
225                 230                 235                 240 


Thr Ser Ser Arg Glu Lys Gln Leu Ser Leu Lys Gln Ser Glu Glu Asn 
                245                 250                 255     


Arg Thr Ser Gly Leu Leu Pro Leu Gln Ser Ser Ser Phe Tyr Gly Ser 
            260                 265                 270         


Arg Ala Gly Ser Lys Glu His Ser Ser Gly Gly Thr Asn Leu Asp Arg 
        275                 280                 285             


Thr Asn Val Ser Ser Gln Thr Pro Ser Ala Lys Arg Ser Leu Gly Phe 
    290                 295                 300                 


Leu Pro Gln Pro Val Pro Leu Ser Val Lys Lys Leu Arg Cys Asn Gln 
305                 310                 315                 320 


Asp Tyr Thr Gly Trp Asn Lys Pro Arg Val Pro Leu Ser Ser His Gln 
                325                 330                 335     


Gln Gln Gln Leu Gln Gly Phe Ser Asn Leu Gly Asn Thr Cys Tyr Met 
            340                 345                 350         


Asn Ala Ile Leu Gln Ser Leu Phe Ser Leu Gln Ser Phe Ala Asn Asp 
        355                 360                 365             


Leu Leu Lys Gln Gly Ile Pro Trp Lys Lys Ile Pro Leu Asn Ala Leu 
    370                 375                 380                 


Ile Arg Arg Phe Ala His Leu Leu Val Lys Lys Asp Ile Cys Asn Ser 
385                 390                 395                 400 


Glu Thr Lys Lys Asp Leu Leu Lys Lys Val Lys Asn Ala Ile Ser Ala 
                405                 410                 415     


Thr Ala Glu Arg Phe Ser Gly Tyr Met Gln Asn Asp Ala His Glu Phe 
            420                 425                 430         


Leu Ser Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn 
        435                 440                 445             


Lys Thr Trp Lys Thr Glu Pro Val Ser Gly Glu Glu Asn Ser Pro Asp 
    450                 455                 460                 


Ile Ser Ala Thr Arg Ala Tyr Thr Cys Pro Val Ile Thr Asn Leu Glu 
465                 470                 475                 480 


Phe Glu Val Gln His Ser Ile Ile Cys Lys Ala Cys Gly Glu Ile Ile 
                485                 490                 495     


Pro Lys Arg Glu Gln Phe Asn Asp Leu Ser Ile Asp Leu Pro Arg Arg 
            500                 505                 510         


Lys Lys Pro Leu Pro Pro Arg Ser Ile Gln Asp Ser Leu Asp Leu Phe 
        515                 520                 525             


Phe Arg Ala Glu Glu Leu Glu Tyr Ser Cys Glu Lys Cys Gly Gly Lys 
    530                 535                 540                 


Cys Ala Leu Val Arg His Lys Phe Asn Arg Leu Pro Arg Val Leu Ile 
545                 550                 555                 560 


Leu His Leu Lys Arg Tyr Ser Phe Asn Val Ala Leu Ser Leu Asn Asn 
                565                 570                 575     


Lys Ile Gly Gln Gln Val Ile Ile Pro Arg Tyr Leu Thr Leu Ser Ser 
            580                 585                 590         


His Cys Thr Glu Asn Thr Lys Pro Pro Phe Thr Leu Gly Trp Ser Ala 
        595                 600                 605             


His Met Ala Ile Ser Arg Pro Leu Lys Ala Ser Gln Met Val Asn Ser 
    610                 615                 620                 


Cys Ile Thr Ser Pro Ser Thr Pro Ser Lys Lys Phe Thr Phe Lys Ser 
625                 630                 635                 640 


Lys Ser Ser Leu Ala Leu Cys Leu Asp Ser Asp Ser Glu Asp Glu Leu 
                645                 650                 655     


Lys Arg Ser Val Ala Leu Ser Gln Arg Leu Cys Glu Met Leu Gly Asn 
            660                 665                 670         


Glu Gln Gln Gln Glu Asp Leu Glu Lys Asp Ser Lys Leu Cys Pro Ile 
        675                 680                 685             


Glu Pro Asp Lys Ser Glu Leu Glu Asn Ser Gly Phe Asp Arg Met Ser 
    690                 695                 700                 


Glu Glu Glu Leu Leu Ala Ala Val Leu Glu Ile Ser Lys Arg Asp Ala 
705                 710                 715                 720 


Ser Pro Ser Leu Ser His Glu Asp Asp Asp Lys Pro Thr Ser Ser Pro 
                725                 730                 735     


Asp Thr Gly Phe Ala Glu Asp Asp Ile Gln Glu Met Pro Glu Asn Pro 
            740                 745                 750         


Asp Thr Met Glu Thr Glu Lys Pro Lys Thr Ile Thr Glu Leu Asp Pro 
        755                 760                 765             


Ala Ser Phe Thr Glu Ile Thr Lys Asp Cys Asp Glu Asn Lys Glu Asn 
    770                 775                 780                 


Lys Thr Pro Glu Gly Ser Gln Gly Glu Val Asp Trp Leu Gln Gln Tyr 
785                 790                 795                 800 


Asp Met Glu Arg Glu Arg Glu Glu Gln Glu Leu Gln Gln Ala Leu Ala 
                805                 810                 815     


Gln Ser Leu Gln Glu Gln Glu Ala Trp Glu Gln Lys Glu Asp Asp Asp 
            820                 825                 830         


Leu Lys Arg Ala Thr Glu Leu Ser Leu Gln Glu Phe Asn Asn Ser Phe 
        835                 840                 845             


Val Asp Ala Leu Gly Ser Asp Glu Asp Ser Gly Asn Glu Asp Val Phe 
    850                 855                 860                 


Asp Met Glu Tyr Thr Glu Ala Glu Ala Glu Glu Leu Lys Arg Asn Ala 
865                 870                 875                 880 


Glu Thr Gly Asn Leu Pro His Ser Tyr Arg Leu Ile Ser Val Val Ser 
                885                 890                 895     


His Ile Gly Ser Thr Ser Ser Ser Gly His Tyr Ile Ser Asp Val Tyr 
            900                 905                 910         


Asp Ile Lys Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Glu Val Ser 
        915                 920                 925             


Lys Ile Gln Glu Ala Ala Val Gln Ser Asp Arg Asp Arg Ser Gly Tyr 
    930                 935                 940                 


Ile Phe Phe Tyr Met His Lys Glu Ile Phe Asp Glu Leu Leu Glu Thr 
945                 950                 955                 960 


Glu Lys Asn Ser Gln Ser Leu Ser Thr Glu Val Gly Lys Thr Thr Arg 
                965                 970                 975     


Gln Ala Leu 
            


<210> 48
<211> 530
<212> PRT
<213> Homo sapiens

<400> 48
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Leu Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Val Pro Glu Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His Pro Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp Arg Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 49
<211> 530
<212> PRT
<213> Homo sapiens

<400> 49
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ser Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Lys Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Gly Lys Val Glu Gly Thr Leu Pro Pro Asn Ala Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Arg Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ala Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 50
<211> 1684
<212> PRT
<213> Homo sapiens

<400> 50
Met Ser Trp Lys Arg Asn Tyr Phe Ser Gly Gly Arg Gly Ser Val Gln 
1               5                   10                  15      


Gly Met Phe Ala Pro Arg Ser Ser Thr Ser Ile Ala Pro Ser Lys Gly 
            20                  25                  30          


Leu Ser Asn Glu Pro Gly Gln Asn Ser Cys Phe Leu Asn Ser Ala Leu 
        35                  40                  45              


Gln Val Leu Trp His Leu Asp Ile Phe Arg Arg Ser Phe Arg Gln Leu 
    50                  55                  60                  


Thr Thr His Lys Cys Met Gly Asp Ser Cys Ile Phe Cys Ala Leu Lys 
65                  70                  75                  80  


Gly Ile Phe Asn Gln Phe Gln Cys Ser Ser Glu Lys Val Leu Pro Ser 
                85                  90                  95      


Asp Thr Leu Arg Ser Ala Leu Ala Lys Thr Phe Gln Asp Glu Gln Arg 
            100                 105                 110         


Phe Gln Leu Gly Ile Met Asp Asp Ala Ala Glu Cys Phe Glu Asn Leu 
        115                 120                 125             


Leu Met Arg Ile His Phe His Ile Ala Asp Glu Thr Lys Glu Asp Ile 
    130                 135                 140                 


Cys Thr Ala Gln His Cys Ile Ser His Gln Lys Phe Ala Met Thr Leu 
145                 150                 155                 160 


Phe Glu Gln Cys Val Cys Thr Ser Cys Gly Ala Thr Ser Asp Pro Leu 
                165                 170                 175     


Pro Phe Ile Gln Met Val His Tyr Ile Ser Thr Thr Ser Leu Cys Asn 
            180                 185                 190         


Gln Ala Ile Cys Met Leu Glu Arg Arg Glu Lys Pro Ser Pro Ser Met 
        195                 200                 205             


Phe Gly Glu Leu Leu Gln Asn Ala Ser Thr Met Gly Asp Leu Arg Asn 
    210                 215                 220                 


Cys Pro Ser Asn Cys Gly Glu Arg Ile Arg Ile Arg Arg Val Leu Met 
225                 230                 235                 240 


Asn Ala Pro Gln Ile Ile Thr Ile Gly Leu Val Trp Asp Ser Asp His 
                245                 250                 255     


Ser Asp Leu Ala Glu Asp Val Ile His Ser Leu Gly Thr Cys Leu Lys 
            260                 265                 270         


Leu Gly Asp Leu Phe Phe Arg Val Thr Asp Asp Arg Ala Lys Gln Ser 
        275                 280                 285             


Glu Leu Tyr Leu Val Gly Met Ile Cys Tyr Tyr Gly Lys His Tyr Ser 
    290                 295                 300                 


Thr Phe Phe Phe Gln Thr Lys Ile Arg Lys Trp Met Tyr Phe Asp Asp 
305                 310                 315                 320 


Ala His Val Lys Glu Ile Gly Pro Lys Trp Lys Asp Val Val Thr Lys 
                325                 330                 335     


Cys Ile Lys Gly His Tyr Gln Pro Leu Leu Leu Leu Tyr Ala Asp Pro 
            340                 345                 350         


Gln Gly Thr Pro Val Ser Thr Gln Asp Leu Pro Pro Gln Ala Glu Phe 
        355                 360                 365             


Gln Ser Tyr Ser Arg Thr Cys Tyr Asp Ser Glu Asp Ser Gly Arg Glu 
    370                 375                 380                 


Pro Ser Ile Ser Ser Asp Thr Arg Thr Asp Ser Ser Thr Glu Ser Tyr 
385                 390                 395                 400 


Pro Tyr Lys His Ser His His Glu Ser Val Val Ser His Phe Ser Ser 
                405                 410                 415     


Asp Ser Gln Gly Thr Val Ile Tyr Asn Val Glu Asn Asp Ser Met Ser 
            420                 425                 430         


Gln Ser Ser Arg Asp Thr Gly His Leu Thr Asp Ser Glu Cys Asn Gln 
        435                 440                 445             


Lys His Thr Ser Lys Lys Gly Ser Leu Ile Glu Arg Lys Arg Ser Ser 
    450                 455                 460                 


Gly Arg Val Arg Arg Lys Gly Asp Glu Pro Gln Ala Ser Gly Tyr His 
465                 470                 475                 480 


Ser Glu Gly Glu Thr Leu Lys Glu Lys Gln Ala Pro Arg Asn Ala Ser 
                485                 490                 495     


Lys Pro Ser Ser Ser Thr Asn Arg Leu Arg Asp Phe Lys Glu Thr Val 
            500                 505                 510         


Ser Asn Met Ile His Asn Arg Pro Ser Leu Ala Ser Gln Thr Asn Val 
        515                 520                 525             


Gly Ser His Cys Arg Gly Arg Gly Gly Asp Gln Pro Asp Lys Lys Pro 
    530                 535                 540                 


Pro Arg Thr Leu Pro Leu His Ser Arg Asp Trp Glu Ile Glu Ser Thr 
545                 550                 555                 560 


Ser Ser Glu Ser Lys Ser Ser Ser Ser Ser Lys Tyr Arg Pro Thr Trp 
                565                 570                 575     


Arg Pro Lys Arg Glu Ser Leu Asn Ile Asp Ser Ile Phe Ser Lys Asp 
            580                 585                 590         


Lys Arg Lys His Cys Gly Tyr Thr Gln Leu Ser Pro Phe Ser Glu Asp 
        595                 600                 605             


Ser Ala Lys Glu Phe Ile Pro Asp Glu Pro Ser Lys Pro Pro Ser Tyr 
    610                 615                 620                 


Asp Ile Lys Phe Gly Gly Pro Ser Pro Gln Tyr Lys Arg Trp Gly Pro 
625                 630                 635                 640 


Ala Arg Pro Gly Ser His Leu Leu Glu Gln His Pro Arg Leu Ile Gln 
                645                 650                 655     


Arg Met Glu Ser Gly Tyr Glu Ser Ser Glu Arg Asn Ser Ser Ser Pro 
            660                 665                 670         


Val Ser Leu Asp Ala Ala Leu Pro Glu Ser Ser Asn Val Tyr Arg Asp 
        675                 680                 685             


Pro Ser Ala Lys Arg Ser Ala Gly Leu Val Pro Ser Trp Arg His Ile 
    690                 695                 700                 


Pro Lys Ser His Ser Ser Ser Ile Leu Glu Val Asp Ser Thr Ala Ser 
705                 710                 715                 720 


Met Gly Gly Trp Thr Lys Ser Gln Pro Phe Ser Gly Glu Glu Ile Ser 
                725                 730                 735     


Ser Lys Ser Glu Leu Asp Glu Leu Gln Glu Glu Val Ala Arg Arg Ala 
            740                 745                 750         


Gln Glu Gln Glu Leu Arg Arg Lys Arg Glu Lys Glu Leu Glu Ala Ala 
        755                 760                 765             


Lys Gly Phe Asn Pro His Pro Ser Arg Phe Met Asp Leu Asp Glu Leu 
    770                 775                 780                 


Gln Asn Gln Gly Arg Ser Asp Gly Phe Glu Arg Ser Leu Gln Glu Ala 
785                 790                 795                 800 


Glu Ser Val Phe Glu Glu Ser Leu His Leu Glu Gln Lys Gly Asp Cys 
                805                 810                 815     


Ala Ala Ala Leu Ala Leu Cys Asn Glu Ala Ile Ser Lys Leu Arg Leu 
            820                 825                 830         


Ala Leu His Gly Ala Ser Cys Ser Thr His Ser Arg Ala Leu Val Asp 
        835                 840                 845             


Lys Lys Leu Gln Ile Ser Ile Arg Lys Ala Arg Ser Leu Gln Asp Arg 
    850                 855                 860                 


Met Gln Gln Gln Gln Ser Pro Gln Gln Pro Ser Gln Pro Ser Ala Cys 
865                 870                 875                 880 


Leu Pro Thr Gln Ala Gly Thr Leu Ser Gln Pro Thr Ser Glu Gln Pro 
                885                 890                 895     


Ile Pro Leu Gln Val Leu Leu Ser Gln Glu Ala Gln Leu Glu Ser Gly 
            900                 905                 910         


Met Asp Thr Glu Phe Gly Ala Ser Ser Phe Phe His Ser Pro Ala Ser 
        915                 920                 925             


Cys His Glu Ser His Ser Ser Leu Ser Pro Glu Ser Ser Ala Pro Gln 
    930                 935                 940                 


His Ser Ser Pro Ser Arg Ser Ala Leu Lys Leu Leu Thr Ser Val Glu 
945                 950                 955                 960 


Val Asp Asn Ile Glu Pro Ser Ala Phe His Arg Gln Gly Leu Pro Lys 
                965                 970                 975     


Ala Pro Gly Trp Thr Glu Lys Asn Ser His His Ser Trp Glu Pro Leu 
            980                 985                 990         


Asp Ala Pro Glu Gly Lys Leu Gln  Gly Ser Arg Cys Asp  Asn Ser Ser 
        995                 1000                 1005             


Cys Ser  Lys Leu Pro Pro Gln  Glu Gly Arg Gly Ile  Ala Gln Glu 
    1010                 1015                 1020             


Gln Leu  Phe Gln Glu Lys Lys  Asp Pro Ala Asn Pro  Ser Pro Val 
    1025                 1030                 1035             


Met Pro  Gly Ile Ala Thr Ser  Glu Arg Gly Asp Glu  His Ser Leu 
    1040                 1045                 1050             


Gly Cys  Ser Pro Ser Asn Ser  Ser Ala Gln Pro Ser  Leu Pro Leu 
    1055                 1060                 1065             


Tyr Arg  Thr Cys His Pro Ile  Met Pro Val Ala Ser  Ser Phe Val 
    1070                 1075                 1080             


Leu His  Cys Pro Asp Pro Val  Gln Lys Thr Asn Gln  Cys Leu Gln 
    1085                 1090                 1095             


Gly Gln  Ser Leu Lys Thr Ser  Leu Thr Leu Lys Val  Asp Arg Gly 
    1100                 1105                 1110             


Ser Glu  Glu Thr Tyr Arg Pro  Glu Phe Pro Ser Thr  Lys Gly Leu 
    1115                 1120                 1125             


Val Arg  Ser Leu Ala Glu Gln  Phe Gln Arg Met Gln  Gly Val Ser 
    1130                 1135                 1140             


Met Arg  Asp Ser Thr Gly Phe  Lys Asp Arg Ser Leu  Ser Gly Ser 
    1145                 1150                 1155             


Leu Arg  Lys Asn Ser Ser Pro  Ser Asp Ser Lys Pro  Pro Phe Ser 
    1160                 1165                 1170             


Gln Gly  Gln Glu Lys Gly His  Trp Pro Trp Ala Lys  Gln Gln Ser 
    1175                 1180                 1185             


Ser Leu  Glu Gly Gly Asp Arg  Pro Leu Ser Trp Glu  Glu Ser Thr 
    1190                 1195                 1200             


Glu His  Ser Ser Leu Ala Leu  Asn Ser Gly Leu Pro  Asn Gly Glu 
    1205                 1210                 1215             


Thr Ser  Ser Gly Gly Gln Pro  Arg Leu Ala Glu Pro  Asp Ile Tyr 
    1220                 1225                 1230             


Gln Glu  Lys Leu Ser Gln Val  Arg Asp Val Arg Ser  Lys Asp Leu 
    1235                 1240                 1245             


Gly Ser  Ser Thr Asp Leu Gly  Thr Ser Leu Pro Leu  Asp Ser Trp 
    1250                 1255                 1260             


Val Asn  Ile Thr Arg Phe Cys  Asp Ser Gln Leu Lys  His Gly Ala 
    1265                 1270                 1275             


Pro Arg  Pro Gly Met Lys Ser  Ser Pro His Asp Ser  His Thr Cys 
    1280                 1285                 1290             


Val Thr  Tyr Pro Glu Arg Asn  His Ile Leu Leu His  Pro His Trp 
    1295                 1300                 1305             


Asn Gln  Asp Thr Glu Gln Glu  Thr Ser Glu Leu Glu  Ser Leu Tyr 
    1310                 1315                 1320             


Gln Ala  Ser Leu Gln Ala Ser  Gln Ala Gly Cys Ser  Gly Trp Gly 
    1325                 1330                 1335             


Gln Gln  Asp Thr Ala Trp His  Pro Leu Ser Gln Thr  Gly Ser Ala 
    1340                 1345                 1350             


Asp Gly  Met Gly Arg Arg Leu  His Ser Ala His Asp  Pro Gly Leu 
    1355                 1360                 1365             


Ser Lys  Thr Ser Thr Ala Glu  Met Glu His Gly Leu  His Glu Ala 
    1370                 1375                 1380             


Arg Thr  Val Arg Thr Ser Gln  Ala Thr Pro Cys Arg  Gly Leu Ser 
    1385                 1390                 1395             


Arg Glu  Cys Gly Glu Asp Glu  Gln Tyr Ser Ala Glu  Asn Leu Arg 
    1400                 1405                 1410             


Arg Ile  Ser Arg Ser Leu Ser  Gly Thr Val Val Ser  Glu Arg Glu 
    1415                 1420                 1425             


Glu Ala  Pro Val Ser Ser His  Ser Phe Asp Ser Ser  Asn Val Arg 
    1430                 1435                 1440             


Lys Pro  Leu Glu Thr Gly His  Arg Cys Ser Ser Ser  Ser Ser Leu 
    1445                 1450                 1455             


Pro Val  Ile His Asp Pro Ser  Val Phe Leu Leu Gly  Pro Gln Leu 
    1460                 1465                 1470             


Tyr Leu  Pro Gln Pro Gln Phe  Leu Ser Pro Asp Val  Leu Met Pro 
    1475                 1480                 1485             


Thr Met  Ala Gly Glu Pro Asn  Arg Leu Pro Gly Thr  Ser Arg Ser 
    1490                 1495                 1500             


Val Gln  Gln Phe Leu Ala Met  Cys Asp Arg Gly Glu  Thr Ser Gln 
    1505                 1510                 1515             


Gly Ala  Lys Tyr Thr Gly Arg  Thr Leu Asn Tyr Gln  Ser Leu Pro 
    1520                 1525                 1530             


His Arg  Ser Arg Thr Asp Asn  Ser Trp Ala Pro Trp  Ser Glu Thr 
    1535                 1540                 1545             


Asn Gln  His Ile Gly Thr Arg  Phe Leu Thr Thr Pro  Gly Cys Asn 
    1550                 1555                 1560             


Pro Gln  Leu Thr Tyr Thr Ala  Thr Leu Pro Glu Arg  Ser Lys Gly 
    1565                 1570                 1575             


Leu Gln  Val Pro His Thr Gln  Ser Trp Ser Asp Leu  Phe His Ser 
    1580                 1585                 1590             


Pro Ser  His Pro Pro Ile Val  His Pro Val Tyr Pro  Pro Ser Ser 
    1595                 1600                 1605             


Ser Leu  His Val Pro Leu Arg  Ser Ala Trp Asn Ser  Asp Pro Val 
    1610                 1615                 1620             


Pro Gly  Ser Arg Thr Pro Gly  Pro Arg Arg Val Asp  Met Pro Pro 
    1625                 1630                 1635             


Asp Asp  Asp Trp Arg Gln Ser  Ser Tyr Ala Ser His  Ser Gly His 
    1640                 1645                 1650             


Arg Arg  Thr Val Gly Glu Gly  Phe Leu Phe Val Leu  Ser Asp Ala 
    1655                 1660                 1665             


Pro Arg  Arg Glu Gln Ile Arg  Ala Arg Val Leu Gln  His Ser Gln 
    1670                 1675                 1680             


Trp 
    


<210> 51
<211> 565
<212> PRT
<213> Homo sapiens

<400> 51
Met Ser Gly Arg Ser Lys Arg Glu Ser Arg Gly Ser Thr Arg Gly Lys 
1               5                   10                  15      


Arg Glu Ser Glu Ser Arg Gly Ser Ser Gly Arg Val Lys Arg Glu Arg 
            20                  25                  30          


Asp Arg Glu Arg Glu Pro Glu Ala Ala Ser Ser Arg Gly Ser Pro Val 
        35                  40                  45              


Arg Val Lys Arg Glu Phe Glu Pro Ala Ser Ala Arg Glu Ala Pro Ala 
    50                  55                  60                  


Ser Val Val Pro Phe Val Arg Val Lys Arg Glu Arg Glu Val Asp Glu 
65                  70                  75                  80  


Asp Ser Glu Pro Glu Arg Glu Val Arg Ala Lys Asn Gly Arg Val Asp 
                85                  90                  95      


Ser Glu Asp Arg Arg Ser Arg His Cys Pro Tyr Leu Asp Thr Ile Asn 
            100                 105                 110         


Arg Ser Val Leu Asp Phe Asp Phe Glu Lys Leu Cys Ser Ile Ser Leu 
        115                 120                 125             


Ser His Ile Asn Ala Tyr Ala Cys Leu Val Cys Gly Lys Tyr Phe Gln 
    130                 135                 140                 


Gly Arg Gly Leu Lys Ser His Ala Tyr Ile His Ser Val Gln Phe Ser 
145                 150                 155                 160 


His His Val Phe Leu Asn Leu His Thr Leu Lys Phe Tyr Cys Leu Pro 
                165                 170                 175     


Asp Asn Tyr Glu Ile Ile Asp Ser Ser Leu Glu Asp Ile Thr Tyr Val 
            180                 185                 190         


Leu Lys Pro Thr Phe Thr Lys Gln Gln Ile Ala Asn Leu Asp Lys Gln 
        195                 200                 205             


Ala Lys Leu Ser Arg Ala Tyr Asp Gly Thr Thr Tyr Leu Pro Gly Ile 
    210                 215                 220                 


Val Gly Leu Asn Asn Ile Lys Ala Asn Asp Tyr Ala Asn Ala Val Leu 
225                 230                 235                 240 


Gln Ala Leu Ser Asn Val Pro Pro Leu Arg Asn Tyr Phe Leu Glu Glu 
                245                 250                 255     


Asp Asn Tyr Lys Asn Ile Lys Arg Pro Pro Gly Asp Ile Met Phe Leu 
            260                 265                 270         


Leu Val Gln Arg Phe Gly Glu Leu Met Arg Lys Leu Trp Asn Pro Arg 
        275                 280                 285             


Asn Phe Lys Ala His Val Ser Pro His Glu Met Leu Gln Ala Val Val 
    290                 295                 300                 


Leu Cys Ser Lys Lys Thr Phe Gln Ile Thr Lys Gln Gly Asp Gly Val 
305                 310                 315                 320 


Asp Phe Leu Ser Trp Phe Leu Asn Ala Leu His Ser Ala Leu Gly Gly 
                325                 330                 335     


Thr Lys Lys Lys Lys Lys Thr Ile Val Thr Asp Val Phe Gln Gly Ser 
            340                 345                 350         


Met Arg Ile Phe Thr Lys Lys Leu Pro His Pro Asp Leu Pro Ala Glu 
        355                 360                 365             


Glu Lys Glu Gln Leu Leu His Asn Asp Glu Tyr Gln Glu Thr Met Val 
    370                 375                 380                 


Glu Ser Thr Phe Met Tyr Leu Thr Leu Asp Leu Pro Thr Ala Pro Leu 
385                 390                 395                 400 


Tyr Lys Asp Glu Lys Glu Gln Leu Ile Ile Pro Gln Val Pro Leu Phe 
                405                 410                 415     


Asn Ile Leu Ala Lys Phe Asn Gly Ile Thr Glu Lys Glu Tyr Lys Thr 
            420                 425                 430         


Tyr Lys Glu Asn Phe Leu Lys Arg Phe Gln Leu Thr Lys Leu Pro Pro 
        435                 440                 445             


Tyr Leu Ile Phe Cys Ile Lys Arg Phe Thr Lys Asn Asn Phe Phe Val 
    450                 455                 460                 


Glu Lys Asn Pro Thr Ile Val Asn Phe Pro Ile Thr Asn Val Asp Leu 
465                 470                 475                 480 


Arg Glu Tyr Leu Ser Glu Glu Val Gln Ala Val His Lys Asn Thr Thr 
                485                 490                 495     


Tyr Asp Leu Ile Ala Asn Ile Val His Asp Gly Lys Pro Ser Glu Gly 
            500                 505                 510         


Ser Tyr Arg Ile His Val Leu His His Gly Thr Gly Lys Trp Tyr Glu 
        515                 520                 525             


Leu Gln Asp Leu Gln Val Thr Asp Ile Leu Pro Gln Met Ile Thr Leu 
    530                 535                 540                 


Ser Glu Ala Tyr Ile Gln Ile Trp Lys Arg Arg Asp Asn Asp Glu Thr 
545                 550                 555                 560 


Asn Gln Gln Gly Ala 
                565 


<210> 52
<211> 1018
<212> PRT
<213> Homo sapiens

<400> 52
Met Asp Lys Ile Leu Glu Ala Val Val Thr Ser Ser Tyr Pro Val Ser 
1               5                   10                  15      


Val Lys Gln Gly Leu Val Arg Arg Val Leu Glu Ala Ala Arg Gln Pro 
            20                  25                  30          


Leu Glu Arg Glu Gln Cys Leu Ala Leu Leu Ala Leu Gly Ala Arg Leu 
        35                  40                  45              


Tyr Val Gly Gly Ala Glu Glu Leu Pro Arg Arg Val Gly Cys Gln Leu 
    50                  55                  60                  


Leu His Val Ala Gly Arg His His Pro Asp Val Phe Ala Glu Phe Phe 
65                  70                  75                  80  


Ser Ala Arg Arg Val Leu Arg Leu Leu Gln Gly Gly Ala Gly Pro Pro 
                85                  90                  95      


Gly Pro Arg Ala Leu Ala Cys Val Gln Leu Gly Leu Gln Leu Leu Pro 
            100                 105                 110         


Glu Gly Pro Ala Ala Asp Glu Val Phe Ala Leu Leu Arg Arg Glu Val 
        115                 120                 125             


Leu Arg Thr Val Cys Glu Arg Pro Gly Pro Ala Ala Cys Ala Gln Val 
    130                 135                 140                 


Ala Arg Leu Leu Ala Arg His Pro Arg Cys Val Pro Asp Gly Pro His 
145                 150                 155                 160 


Arg Leu Leu Phe Cys Gln Gln Leu Val Arg Cys Leu Gly Arg Phe Arg 
                165                 170                 175     


Cys Pro Ala Glu Gly Glu Glu Gly Ala Val Glu Phe Leu Glu Gln Ala 
            180                 185                 190         


Gln Gln Val Ser Gly Leu Leu Ala Gln Leu Trp Arg Ala Gln Pro Ala 
        195                 200                 205             


Ala Ile Leu Pro Cys Leu Lys Glu Leu Phe Ala Val Ile Ser Cys Ala 
    210                 215                 220                 


Glu Glu Glu Pro Pro Ser Ser Ala Leu Ala Ser Val Val Gln His Leu 
225                 230                 235                 240 


Pro Leu Glu Leu Met Asp Gly Val Val Arg Asn Leu Ser Asn Asp Asp 
                245                 250                 255     


Ser Val Thr Asp Ser Gln Met Leu Thr Ala Ile Ser Arg Met Ile Asp 
            260                 265                 270         


Trp Val Ser Trp Pro Leu Gly Lys Asn Ile Asp Lys Trp Ile Ile Ala 
        275                 280                 285             


Leu Leu Lys Gly Leu Ala Ala Val Lys Lys Phe Ser Ile Leu Ile Glu 
    290                 295                 300                 


Val Ser Leu Thr Lys Ile Glu Lys Val Phe Ser Lys Leu Leu Tyr Pro 
305                 310                 315                 320 


Ile Val Arg Gly Ala Ala Leu Ser Val Leu Lys Tyr Met Leu Leu Thr 
                325                 330                 335     


Phe Gln His Ser His Glu Ala Phe His Leu Leu Leu Pro His Ile Pro 
            340                 345                 350         


Pro Met Val Ala Ser Leu Val Lys Glu Asp Ser Asn Ser Gly Thr Ser 
        355                 360                 365             


Cys Leu Glu Gln Leu Ala Glu Leu Val His Cys Met Val Phe Arg Phe 
    370                 375                 380                 


Pro Gly Phe Pro Asp Leu Tyr Glu Pro Val Met Glu Ala Ile Lys Asp 
385                 390                 395                 400 


Leu His Val Pro Asn Glu Asp Arg Ile Lys Gln Leu Leu Gly Gln Asp 
                405                 410                 415     


Ala Trp Thr Ser Gln Lys Ser Glu Leu Ala Gly Phe Tyr Pro Arg Leu 
            420                 425                 430         


Met Ala Lys Ser Asp Thr Gly Lys Ile Gly Leu Ile Asn Leu Gly Asn 
        435                 440                 445             


Thr Cys Tyr Val Asn Ser Ile Leu Gln Ala Leu Phe Met Ala Ser Asp 
    450                 455                 460                 


Phe Arg His Cys Val Leu Arg Leu Thr Glu Asn Asn Ser Gln Pro Leu 
465                 470                 475                 480 


Met Thr Lys Leu Gln Trp Leu Phe Gly Phe Leu Glu His Ser Gln Arg 
                485                 490                 495     


Pro Ala Ile Ser Pro Glu Asn Phe Leu Ser Ala Ser Trp Thr Pro Trp 
            500                 505                 510         


Phe Ser Pro Gly Thr Gln Gln Asp Cys Ser Glu Tyr Leu Lys Tyr Leu 
        515                 520                 525             


Leu Asp Arg Leu His Glu Glu Glu Lys Thr Gly Thr Arg Ile Cys Gln 
    530                 535                 540                 


Lys Leu Lys Gln Ser Ser Ser Pro Ser Pro Pro Glu Glu Pro Pro Ala 
545                 550                 555                 560 


Pro Ser Ser Thr Ser Val Glu Lys Met Phe Gly Gly Lys Ile Val Thr 
                565                 570                 575     


Arg Ile Cys Cys Leu Cys Cys Leu Asn Val Ser Ser Arg Glu Glu Ala 
            580                 585                 590         


Phe Thr Asp Leu Ser Leu Ala Phe Pro Pro Pro Glu Arg Cys Arg Arg 
        595                 600                 605             


Arg Arg Leu Gly Ser Val Met Arg Pro Thr Glu Asp Ile Thr Ala Arg 
    610                 615                 620                 


Glu Leu Pro Pro Pro Thr Ser Ala Gln Gly Pro Gly Arg Val Gly Pro 
625                 630                 635                 640 


Arg Arg Gln Arg Lys His Cys Ile Thr Glu Asp Thr Pro Pro Thr Ser 
                645                 650                 655     


Leu Tyr Ile Glu Gly Leu Asp Ser Lys Glu Ala Gly Gly Gln Ser Ser 
            660                 665                 670         


Gln Glu Glu Arg Ile Glu Arg Glu Glu Glu Gly Lys Glu Glu Arg Thr 
        675                 680                 685             


Glu Lys Glu Glu Val Gly Glu Glu Glu Glu Ser Thr Arg Gly Glu Gly 
    690                 695                 700                 


Glu Arg Glu Lys Glu Glu Glu Val Glu Glu Glu Glu Glu Lys Val Glu 
705                 710                 715                 720 


Lys Glu Thr Glu Lys Glu Ala Glu Gln Glu Lys Glu Glu Asp Ser Leu 
                725                 730                 735     


Gly Ala Gly Thr His Pro Asp Ala Ala Ile Pro Ser Gly Glu Arg Thr 
            740                 745                 750         


Cys Gly Ser Glu Gly Ser Arg Ser Val Leu Asp Leu Val Asn Tyr Phe 
        755                 760                 765             


Leu Ser Pro Glu Lys Leu Thr Ala Glu Asn Arg Tyr Tyr Cys Glu Ser 
    770                 775                 780                 


Cys Ala Ser Leu Gln Asp Ala Glu Lys Val Val Glu Leu Ser Gln Gly 
785                 790                 795                 800 


Pro Cys Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Phe Asp Leu Arg 
                805                 810                 815     


Thr Met Arg Arg Arg Lys Ile Leu Asp Asp Val Ser Ile Pro Leu Leu 
            820                 825                 830         


Leu Arg Leu Pro Leu Ala Gly Gly Arg Gly Gln Ala Tyr Asp Leu Cys 
        835                 840                 845             


Ser Val Val Val His Ser Gly Val Ser Ser Glu Ser Gly His Tyr Tyr 
    850                 855                 860                 


Cys Tyr Ala Arg Glu Gly Ala Ala Arg Pro Ala Ala Ser Leu Gly Thr 
865                 870                 875                 880 


Ala Asp Arg Pro Glu Pro Glu Asn Gln Trp Tyr Leu Phe Asn Asp Thr 
                885                 890                 895     


Arg Val Ser Phe Ser Ser Phe Glu Ser Val Ser Asn Val Thr Ser Phe 
            900                 905                 910         


Phe Pro Lys Asp Thr Ala Tyr Val Leu Phe Tyr Arg Gln Arg Pro Arg 
        915                 920                 925             


Glu Gly Pro Glu Ala Glu Leu Gly Ser Ser Arg Val Arg Thr Glu Pro 
    930                 935                 940                 


Thr Leu His Lys Asp Leu Met Glu Ala Ile Ser Lys Asp Asn Ile Leu 
945                 950                 955                 960 


Tyr Leu Gln Glu Gln Glu Lys Glu Ala Arg Ser Arg Ala Ala Tyr Ile 
                965                 970                 975     


Ser Ala Leu Pro Thr Ser Pro His Trp Gly Arg Gly Phe Asp Glu Asp 
            980                 985                 990         


Lys Asp Glu Asp Glu Gly Ser Pro  Gly Gly Cys Asn Pro  Ala Gly Gly 
        995                 1000                 1005             


Asn Gly  Gly Asp Phe His Arg  Leu Val Phe 
    1010                 1015             


<210> 53
<211> 981
<212> PRT
<213> Homo sapiens

<400> 53
Met Ala Glu Gly Gly Ala Ala Asp Leu Asp Thr Gln Arg Ser Asp Ile 
1               5                   10                  15      


Ala Thr Leu Leu Lys Thr Ser Leu Arg Lys Gly Asp Thr Trp Tyr Leu 
            20                  25                  30          


Val Asp Ser Arg Trp Phe Lys Gln Trp Lys Lys Tyr Val Gly Phe Asp 
        35                  40                  45              


Ser Trp Asp Lys Tyr Gln Met Gly Asp Gln Asn Val Tyr Pro Gly Pro 
    50                  55                  60                  


Ile Asp Asn Ser Gly Leu Leu Lys Asp Gly Asp Ala Gln Ser Leu Lys 
65                  70                  75                  80  


Glu His Leu Ile Asp Glu Leu Asp Tyr Ile Leu Leu Pro Thr Glu Gly 
                85                  90                  95      


Trp Asn Lys Leu Val Ser Trp Tyr Thr Leu Met Glu Gly Gln Glu Pro 
            100                 105                 110         


Ile Ala Arg Lys Val Val Glu Gln Gly Met Phe Val Lys His Cys Lys 
        115                 120                 125             


Val Glu Val Tyr Leu Thr Glu Leu Lys Leu Cys Glu Asn Gly Asn Met 
    130                 135                 140                 


Asn Asn Val Val Thr Arg Arg Phe Ser Lys Ala Asp Thr Ile Asp Thr 
145                 150                 155                 160 


Ile Glu Lys Glu Ile Arg Lys Ile Phe Ser Ile Pro Asp Glu Lys Glu 
                165                 170                 175     


Thr Arg Leu Trp Asn Lys Tyr Met Ser Asn Thr Phe Glu Pro Leu Asn 
            180                 185                 190         


Lys Pro Asp Ser Thr Ile Gln Asp Ala Gly Leu Tyr Gln Gly Gln Val 
        195                 200                 205             


Leu Val Ile Glu Gln Lys Asn Glu Asp Gly Thr Trp Pro Arg Gly Pro 
    210                 215                 220                 


Ser Thr Pro Lys Ser Pro Gly Ala Ser Asn Phe Ser Thr Leu Pro Lys 
225                 230                 235                 240 


Ile Ser Pro Ser Ser Leu Ser Asn Asn Tyr Asn Asn Met Asn Asn Arg 
                245                 250                 255     


Asn Val Lys Asn Ser Asn Tyr Cys Leu Pro Ser Tyr Thr Ala Tyr Lys 
            260                 265                 270         


Asn Tyr Asp Tyr Ser Glu Pro Gly Arg Asn Asn Glu Gln Pro Gly Leu 
        275                 280                 285             


Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn Ser Ala Ile 
    290                 295                 300                 


Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu Tyr Phe Leu Asn Asp 
305                 310                 315                 320 


Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro Leu Gly Met Arg Gly 
                325                 330                 335     


Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys Gln Met Trp Ser Gly 
            340                 345                 350         


Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys Thr Gln Val Gly Arg 
        355                 360                 365             


Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln Asp Cys Gln Glu Leu 
    370                 375                 380                 


Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn Arg Ile Arg 
385                 390                 395                 400 


Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp Gly Arg Pro Asp Lys 
                405                 410                 415     


Val Val Ala Glu Glu Ala Trp Glu Asn His Leu Lys Arg Asn Asp Ser 
            420                 425                 430         


Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys Ser Thr Leu Val Cys 
        435                 440                 445             


Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp Pro Phe Cys Tyr Leu 
    450                 455                 460                 


Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr Leu Glu Val Tyr Leu 
465                 470                 475                 480 


Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln Tyr Lys Val Val Val 
                485                 490                 495     


Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr Ala Leu Ser Ala Leu 
            500                 505                 510         


Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr Asp Ile Tyr Asn His 
        515                 520                 525             


Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn Leu Ser Ser Ile Met 
    530                 535                 540                 


Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn Ile Asn Arg Thr Glu 
545                 550                 555                 560 


Asp Thr Glu His Val Ile Ile Pro Val Cys Leu Arg Glu Lys Phe Arg 
                565                 570                 575     


His Ser Ser Tyr Thr His His Thr Gly Ser Ser Leu Phe Gly Gln Pro 
            580                 585                 590         


Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu Asp Lys Leu Tyr Asn 
        595                 600                 605             


Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys Ile Ser Thr Glu Thr 
    610                 615                 620                 


Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys Asp Gln Asn Ile Asn 
625                 630                 635                 640 


Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly Ser Pro Ser Glu Met 
                645                 650                 655     


Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln Asp Gln Glu Leu Pro 
            660                 665                 670         


Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser Val Gly Gly Asp Asn 
        675                 680                 685             


Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr Cys Lys Gly Gln Leu 
    690                 695                 700                 


Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln Phe Asn Asn Leu Gly 
705                 710                 715                 720 


Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr Arg His Ile Arg Phe 
                725                 730                 735     


Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser Phe Leu Ala Leu Asp 
            740                 745                 750         


Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp Glu Asn Ala Ala Glu 
        755                 760                 765             


Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys Pro Pro Lys Lys Pro 
    770                 775                 780                 


Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe Thr Thr Lys Glu Lys 
785                 790                 795                 800 


Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn Cys Lys Glu His Gln 
                805                 810                 815     


Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu Pro Pro Val Leu Val 
            820                 825                 830         


Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr Met Arg Asp Lys Leu 
        835                 840                 845             


Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu Asp Met Ser Glu Phe 
    850                 855                 860                 


Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr Asn Leu Ile Ala Val 
865                 870                 875                 880 


Ser Asn His Tyr Gly Gly Met Gly Gly Gly His Tyr Thr Ala Phe Ala 
                885                 890                 895     


Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe Asp Asp Ser Ser Val 
            900                 905                 910         


Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys Ala Ala Tyr Val Leu 
        915                 920                 925             


Phe Tyr Gln Arg Gln Asp Thr Phe Ser Gly Thr Gly Phe Phe Pro Leu 
    930                 935                 940                 


Asp Arg Glu Thr Lys Gly Ala Ser Ala Ala Thr Gly Ile Pro Leu Glu 
945                 950                 955                 960 


Ser Asp Glu Asp Ser Asn Asp Asn Asp Asn Asp Ile Glu Asn Glu Asn 
                965                 970                 975     


Cys Met His Thr Asn 
            980     


<210> 54
<211> 922
<212> PRT
<213> Homo sapiens

<400> 54
Met Ile Ser Leu Lys Val Cys Gly Phe Ile Gln Ile Trp Ser Gln Lys 
1               5                   10                  15      


Thr Gly Met Thr Lys Leu Lys Glu Ala Leu Ile Glu Thr Val Gln Arg 
            20                  25                  30          


Gln Lys Glu Ile Lys Leu Val Val Thr Phe Lys Ser Gly Lys Phe Ile 
        35                  40                  45              


Arg Ile Phe Gln Leu Ser Asn Asn Ile Arg Ser Val Val Leu Arg His 
    50                  55                  60                  


Cys Lys Lys Arg Gln Ser His Leu Arg Leu Thr Leu Lys Asn Asn Val 
65                  70                  75                  80  


Phe Leu Phe Ile Asp Lys Leu Ser Tyr Arg Asp Ala Lys Gln Leu Asn 
                85                  90                  95      


Met Phe Leu Asp Ile Ile His Gln Asn Lys Ser Gln Gln Pro Met Lys 
            100                 105                 110         


Ser Asp Asp Asp Trp Ser Val Phe Glu Ser Arg Asn Met Leu Lys Glu 
        115                 120                 125             


Ile Asp Lys Thr Ser Phe Tyr Ser Ile Cys Asn Lys Pro Ser Tyr Gln 
    130                 135                 140                 


Lys Met Pro Leu Phe Met Ser Lys Ser Pro Thr His Val Lys Lys Gly 
145                 150                 155                 160 


Ile Leu Glu Asn Gln Gly Gly Lys Gly Gln Asn Thr Leu Ser Ser Asp 
                165                 170                 175     


Val Gln Thr Asn Glu Asp Ile Leu Lys Glu Asp Asn Pro Val Pro Asn 
            180                 185                 190         


Lys Lys Tyr Lys Thr Asp Ser Leu Lys Tyr Ile Gln Ser Asn Arg Lys 
        195                 200                 205             


Asn Pro Ser Ser Leu Glu Asp Leu Glu Lys Asp Arg Asp Leu Lys Leu 
    210                 215                 220                 


Gly Pro Ser Phe Asn Thr Asn Cys Asn Gly Asn Pro Asn Leu Asp Glu 
225                 230                 235                 240 


Thr Val Leu Ala Thr Gln Thr Leu Asn Ala Lys Asn Gly Leu Thr Ser 
                245                 250                 255     


Pro Leu Glu Pro Glu His Ser Gln Gly Asp Pro Arg Cys Asn Lys Ala 
            260                 265                 270         


Gln Val Pro Leu Asp Ser His Ser Gln Gln Leu Gln Gln Gly Phe Pro 
        275                 280                 285             


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ala Val Leu Gln Ser Leu Phe 
    290                 295                 300                 


Ala Ile Pro Ser Phe Ala Asp Asp Leu Leu Thr Gln Gly Val Pro Trp 
305                 310                 315                 320 


Glu Tyr Ile Pro Phe Glu Ala Leu Ile Met Thr Leu Thr Gln Leu Leu 
                325                 330                 335     


Ala Leu Lys Asp Phe Cys Ser Thr Lys Ile Lys Arg Glu Leu Leu Gly 
            340                 345                 350         


Asn Val Lys Lys Val Ile Ser Ala Val Ala Glu Ile Phe Ser Gly Asn 
        355                 360                 365             


Met Gln Asn Asp Ala His Glu Phe Leu Gly Gln Cys Leu Asp Gln Leu 
    370                 375                 380                 


Lys Glu Asp Met Glu Lys Leu Asn Ala Thr Leu Asn Thr Gly Lys Glu 
385                 390                 395                 400 


Cys Gly Asp Glu Asn Ser Ser Pro Gln Met His Val Gly Ser Ala Ala 
                405                 410                 415     


Thr Lys Val Phe Val Cys Pro Val Val Ala Asn Phe Glu Phe Glu Leu 
            420                 425                 430         


Gln Leu Ser Leu Ile Cys Lys Ala Cys Gly His Ala Val Leu Lys Val 
        435                 440                 445             


Glu Pro Asn Asn Tyr Leu Ser Ile Asn Leu His Gln Glu Thr Lys Pro 
    450                 455                 460                 


Leu Pro Leu Ser Ile Gln Asn Ser Leu Asp Leu Phe Phe Lys Glu Glu 
465                 470                 475                 480 


Glu Leu Glu Tyr Asn Cys Gln Met Cys Lys Gln Lys Ser Cys Val Ala 
                485                 490                 495     


Arg His Thr Phe Ser Arg Leu Ser Arg Val Leu Ile Ile His Leu Lys 
            500                 505                 510         


Arg Tyr Ser Phe Asn Asn Ala Trp Leu Leu Val Lys Asn Asn Glu Gln 
        515                 520                 525             


Val Tyr Ile Pro Lys Ser Leu Ser Leu Ser Ser Tyr Cys Asn Glu Ser 
    530                 535                 540                 


Thr Lys Pro Pro Leu Pro Leu Ser Ser Ser Ala Pro Val Gly Lys Cys 
545                 550                 555                 560 


Glu Val Leu Glu Val Ser Gln Glu Met Ile Ser Glu Ile Asn Ser Pro 
                565                 570                 575     


Leu Thr Pro Ser Met Lys Leu Thr Ser Glu Ser Ser Asp Ser Leu Val 
            580                 585                 590         


Leu Pro Val Glu Pro Asp Lys Asn Ala Asp Leu Gln Arg Phe Gln Arg 
        595                 600                 605             


Asp Cys Gly Asp Ala Ser Gln Glu Gln His Gln Arg Asp Leu Glu Asn 
    610                 615                 620                 


Gly Ser Ala Leu Glu Ser Glu Leu Val His Phe Arg Asp Arg Ala Ile 
625                 630                 635                 640 


Gly Glu Lys Glu Leu Pro Val Ala Asp Ser Leu Met Asp Gln Gly Asp 
                645                 650                 655     


Ile Ser Leu Pro Val Met Tyr Glu Asp Gly Gly Lys Leu Ile Ser Ser 
            660                 665                 670         


Pro Asp Thr Arg Leu Val Glu Val His Leu Gln Glu Val Pro Gln His 
        675                 680                 685             


Pro Glu Leu Gln Lys Tyr Glu Lys Thr Asn Thr Phe Val Glu Phe Asn 
    690                 695                 700                 


Phe Asp Ser Val Thr Glu Ser Thr Asn Gly Phe Tyr Asp Cys Lys Glu 
705                 710                 715                 720 


Asn Arg Ile Pro Glu Gly Ser Gln Gly Met Ala Glu Gln Leu Gln Gln 
                725                 730                 735     


Cys Ile Glu Glu Ser Ile Ile Asp Glu Phe Leu Gln Gln Ala Pro Pro 
            740                 745                 750         


Pro Gly Val Arg Lys Leu Asp Ala Gln Glu His Thr Glu Glu Thr Leu 
        755                 760                 765             


Asn Gln Ser Thr Glu Leu Arg Leu Gln Lys Ala Asp Leu Asn His Leu 
    770                 775                 780                 


Gly Ala Leu Gly Ser Asp Asn Pro Gly Asn Lys Asn Ile Leu Asp Ala 
785                 790                 795                 800 


Glu Asn Thr Arg Gly Glu Ala Lys Glu Leu Thr Arg Asn Val Lys Met 
                805                 810                 815     


Gly Asp Pro Leu Gln Ala Tyr Arg Leu Ile Ser Val Val Ser His Ile 
            820                 825                 830         


Gly Ser Ser Pro Asn Ser Gly His Tyr Ile Ser Asp Val Tyr Asp Phe 
        835                 840                 845             


Gln Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Cys Val Ser Glu Ile 
    850                 855                 860                 


Ser Glu Thr Lys Met Gln Glu Ala Arg Leu His Ser Gly Tyr Ile Phe 
865                 870                 875                 880 


Phe Tyr Met His Asn Gly Ile Phe Glu Glu Leu Leu Arg Lys Ala Glu 
                885                 890                 895     


Asn Ser Arg Leu Pro Ser Thr Gln Ala Gly Val Ile Pro Gln Gly Glu 
            900                 905                 910         


Tyr Glu Gly Asp Ser Leu Tyr Arg Pro Ala 
        915                 920         


<210> 55
<211> 1406
<212> PRT
<213> Homo sapiens

<400> 55
Met Asp Met Val Glu Asn Ala Asp Ser Leu Gln Ala Gln Glu Arg Lys 
1               5                   10                  15      


Asp Ile Leu Met Lys Tyr Asp Lys Gly His Arg Ala Gly Leu Pro Glu 
            20                  25                  30          


Asp Lys Gly Pro Glu Pro Val Gly Ile Asn Ser Ser Ile Asp Arg Phe 
        35                  40                  45              


Gly Ile Leu His Glu Thr Glu Leu Pro Pro Val Thr Ala Arg Glu Ala 
    50                  55                  60                  


Lys Lys Ile Arg Arg Glu Met Thr Arg Thr Ser Lys Trp Met Glu Met 
65                  70                  75                  80  


Leu Gly Glu Trp Glu Thr Tyr Lys His Ser Ser Lys Leu Ile Asp Arg 
                85                  90                  95      


Val Tyr Lys Gly Ile Pro Met Asn Ile Arg Gly Pro Val Trp Ser Val 
            100                 105                 110         


Leu Leu Asn Ile Gln Glu Ile Lys Leu Lys Asn Pro Gly Arg Tyr Gln 
        115                 120                 125             


Ile Met Lys Glu Arg Gly Lys Arg Ser Ser Glu His Ile His His Ile 
    130                 135                 140                 


Asp Leu Asp Val Arg Thr Thr Leu Arg Asn His Val Phe Phe Arg Asp 
145                 150                 155                 160 


Arg Tyr Gly Ala Lys Gln Arg Glu Leu Phe Tyr Ile Leu Leu Ala Tyr 
                165                 170                 175     


Ser Glu Tyr Asn Pro Glu Val Gly Tyr Cys Arg Asp Leu Ser His Ile 
            180                 185                 190         


Thr Ala Leu Phe Leu Leu Tyr Leu Pro Glu Glu Asp Ala Phe Trp Ala 
        195                 200                 205             


Leu Val Gln Leu Leu Ala Ser Glu Arg His Ser Leu Pro Gly Phe His 
    210                 215                 220                 


Ser Pro Asn Gly Gly Thr Val Gln Gly Leu Gln Asp Gln Gln Glu His 
225                 230                 235                 240 


Val Val Pro Lys Ser Gln Pro Lys Thr Met Trp His Gln Asp Lys Glu 
                245                 250                 255     


Gly Leu Cys Gly Gln Cys Ala Ser Leu Gly Cys Leu Leu Arg Asn Leu 
            260                 265                 270         


Ile Asp Gly Ile Ser Leu Gly Leu Thr Leu Arg Leu Trp Asp Val Tyr 
        275                 280                 285             


Leu Val Glu Gly Glu Gln Val Leu Met Pro Ile Thr Ser Ile Ala Leu 
    290                 295                 300                 


Lys Val Gln Gln Lys Arg Leu Met Lys Thr Ser Arg Cys Gly Leu Trp 
305                 310                 315                 320 


Ala Arg Leu Arg Asn Gln Phe Phe Asp Thr Trp Ala Met Asn Asp Asp 
                325                 330                 335     


Thr Val Leu Lys His Leu Arg Ala Ser Thr Lys Lys Leu Thr Arg Lys 
            340                 345                 350         


Gln Gly Asp Leu Pro Pro Pro Ala Lys Arg Glu Gln Gly Ser Leu Ala 
        355                 360                 365             


Pro Arg Pro Val Pro Ala Ser Arg Gly Gly Lys Thr Leu Cys Lys Gly 
    370                 375                 380                 


Tyr Arg Gln Ala Pro Pro Gly Pro Pro Ala Gln Phe Gln Arg Pro Ile 
385                 390                 395                 400 


Cys Ser Ala Ser Pro Pro Trp Ala Ser Arg Phe Ser Thr Pro Cys Pro 
                405                 410                 415     


Gly Gly Ala Val Arg Glu Asp Thr Tyr Pro Val Gly Thr Gln Gly Val 
            420                 425                 430         


Pro Ser Leu Ala Leu Ala Gln Gly Gly Pro Gln Gly Ser Trp Arg Phe 
        435                 440                 445             


Leu Glu Trp Lys Ser Met Pro Arg Leu Pro Thr Asp Leu Asp Ile Gly 
    450                 455                 460                 


Gly Pro Trp Phe Pro His Tyr Asp Phe Glu Trp Ser Cys Trp Val Arg 
465                 470                 475                 480 


Ala Ile Ser Gln Glu Asp Gln Leu Ala Thr Cys Trp Gln Ala Glu His 
                485                 490                 495     


Cys Gly Glu Val His Asn Lys Asp Met Ser Trp Pro Glu Glu Met Ser 
            500                 505                 510         


Phe Thr Ala Asn Ser Ser Lys Ile Asp Arg Gln Lys Val Pro Thr Glu 
        515                 520                 525             


Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn 
    530                 535                 540                 


Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe 
545                 550                 555                 560 


Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly 
                565                 570                 575     


Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu 
            580                 585                 590         


Trp Ser Gly Thr Gln Lys Ser Val Ala Pro Leu Lys Leu Arg Arg Thr 
        595                 600                 605             


Ile Ala Lys Tyr Ala Pro Lys Phe Asp Gly Phe Gln Gln Gln Asp Ser 
    610                 615                 620                 


Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn 
625                 630                 635                 640 


Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg 
                645                 650                 655     


Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg 
            660                 665                 670         


Asn Arg Ser Ile Ile Val Asp Leu Phe His Gly Gln Leu Arg Ser Gln 
        675                 680                 685             


Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Phe 
    690                 695                 700                 


Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met Asp Leu Glu 
705                 710                 715                 720 


Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu 
                725                 730                 735     


Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Arg 
            740                 745                 750         


Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His 
        755                 760                 765             


Asp Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Gln Leu 
    770                 775                 780                 


Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Ser Ser 
785                 790                 795                 800 


Pro Ile Ser Ala Ser Ser Pro Thr Gln Ile Asp Phe Ser Ser Ser Pro 
                805                 810                 815     


Ser Thr Asn Gly Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Lys 
            820                 825                 830         


Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly 
        835                 840                 845             


Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser 
    850                 855                 860                 


Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys 
865                 870                 875                 880 


Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Pro Gln Glu Asn Arg Pro 
                885                 890                 895     


Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg 
            900                 905                 910         


Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Trp Leu Ala 
        915                 920                 925             


Arg Pro Leu Pro Pro Gln Glu Ala Ser Ile His Ala Gln Asp Arg Asp 
    930                 935                 940                 


Asn Cys Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys 
945                 950                 955                 960 


Asp Gly Asn Ser Cys Ala Trp Cys Pro Gln Tyr Arg Phe Cys Arg Gly 
                965                 970                 975     


Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr 
            980                 985                 990         


Ile Ala Val Asp Trp His Pro Thr  Ala Leu His Leu Arg  Tyr Gln Thr 
        995                 1000                 1005             


Ser Gln  Glu Arg Val Val Asp  Lys His Glu Ser Val  Glu Gln Ser 
    1010                 1015                 1020             


Arg Arg  Ala Gln Ala Glu Pro  Ile Asn Leu Asp Ser  Cys Leu Arg 
    1025                 1030                 1035             


Ala Phe  Thr Ser Glu Glu Glu  Leu Gly Glu Ser Glu  Met Tyr Tyr 
    1040                 1045                 1050             


Cys Ser  Lys Cys Lys Thr His  Cys Leu Ala Thr Lys  Lys Leu Asp 
    1055                 1060                 1065             


Leu Trp  Arg Leu Pro Pro Phe  Leu Ile Ile His Leu  Lys Arg Phe 
    1070                 1075                 1080             


Gln Phe  Val Asn Asp Gln Trp  Ile Lys Ser Gln Lys  Ile Val Arg 
    1085                 1090                 1095             


Phe Leu  Arg Glu Ser Phe Asp  Pro Ser Ala Phe Leu  Val Pro Arg 
    1100                 1105                 1110             


Asp Pro  Ala Leu Cys Gln His  Lys Pro Leu Thr Pro  Gln Gly Asp 
    1115                 1120                 1125             


Glu Leu  Ser Lys Pro Arg Ile  Leu Ala Arg Glu Val  Lys Lys Val 
    1130                 1135                 1140             


Asp Ala  Gln Ser Ser Ala Gly  Lys Glu Asp Met Leu  Leu Ser Lys 
    1145                 1150                 1155             


Ser Pro  Ser Ser Leu Ser Ala  Asn Ile Ser Ser Ser  Pro Lys Gly 
    1160                 1165                 1170             


Ser Pro  Ser Ser Ser Arg Lys  Ser Gly Thr Ser Cys  Pro Ser Ser 
    1175                 1180                 1185             


Lys Asn  Ser Ser Pro Asn Ser  Ser Pro Arg Thr Leu  Gly Arg Ser 
    1190                 1195                 1200             


Lys Gly  Arg Leu Arg Leu Pro  Gln Ile Gly Ser Lys  Asn Lys Pro 
    1205                 1210                 1215             


Ser Ser  Ser Lys Lys Asn Leu  Asp Ala Ser Lys Glu  Asn Gly Ala 
    1220                 1225                 1230             


Gly Gln  Ile Cys Glu Leu Ala  Asp Ala Leu Ser Arg  Gly His Met 
    1235                 1240                 1245             


Arg Gly  Gly Ser Gln Pro Glu  Leu Val Thr Pro Gln  Asp His Glu 
    1250                 1255                 1260             


Val Ala  Leu Ala Asn Gly Phe  Leu Tyr Glu His Glu  Ala Cys Gly 
    1265                 1270                 1275             


Asn Gly  Cys Gly Asp Gly Tyr  Ser Asn Gly Gln Leu  Gly Asn His 
    1280                 1285                 1290             


Ser Glu  Glu Asp Ser Thr Asp  Asp Gln Arg Glu Asp  Thr His Ile 
    1295                 1300                 1305             


Lys Pro  Ile Tyr Asn Leu Tyr  Ala Ile Ser Cys His  Ser Gly Ile 
    1310                 1315                 1320             


Leu Ser  Gly Gly His Tyr Ile  Thr Tyr Ala Lys Asn  Pro Asn Cys 
    1325                 1330                 1335             


Lys Trp  Tyr Cys Tyr Asn Asp  Ser Ser Cys Glu Glu  Leu His Pro 
    1340                 1345                 1350             


Asp Glu  Ile Asp Thr Asp Ser  Ala Tyr Ile Leu Phe  Tyr Glu Gln 
    1355                 1360                 1365             


Gln Gly  Ile Asp Tyr Ala Gln  Phe Leu Pro Lys Ile  Asp Gly Lys 
    1370                 1375                 1380             


Lys Met  Ala Asp Thr Ser Ser  Thr Asp Glu Asp Ser  Glu Ser Asp 
    1385                 1390                 1395             


Tyr Glu  Lys Tyr Ser Met Leu  Gln 
    1400                 1405     


<210> 56
<211> 1073
<212> PRT
<213> Homo sapiens

<400> 56
Met Ala Trp Val Lys Phe Leu Arg Lys Pro Gly Gly Asn Leu Gly Lys 
1               5                   10                  15      


Val Tyr Gln Pro Gly Ser Met Leu Ser Leu Ala Pro Thr Lys Gly Leu 
            20                  25                  30          


Leu Asn Glu Pro Gly Gln Asn Ser Cys Phe Leu Asn Ser Ala Val Gln 
        35                  40                  45              


Val Leu Trp Gln Leu Asp Ile Phe Arg Arg Ser Leu Arg Val Leu Thr 
    50                  55                  60                  


Gly His Val Cys Gln Gly Asp Ala Cys Ile Phe Cys Ala Leu Lys Thr 
65                  70                  75                  80  


Ile Phe Ala Gln Phe Gln His Ser Arg Glu Lys Ala Leu Pro Ser Asp 
                85                  90                  95      


Asn Ile Arg His Ala Leu Ala Glu Ser Phe Lys Asp Glu Gln Arg Phe 
            100                 105                 110         


Gln Leu Gly Leu Met Asp Asp Ala Ala Glu Cys Phe Glu Asn Met Leu 
        115                 120                 125             


Glu Arg Ile His Phe His Ile Val Pro Ser Arg Asp Ala Asp Met Cys 
    130                 135                 140                 


Thr Ser Lys Ser Cys Ile Thr His Gln Lys Phe Ala Met Thr Leu Tyr 
145                 150                 155                 160 


Glu Gln Cys Val Cys Arg Ser Cys Gly Ala Ser Ser Asp Pro Leu Pro 
                165                 170                 175     


Phe Thr Glu Phe Val Arg Tyr Ile Ser Thr Thr Ala Leu Cys Asn Glu 
            180                 185                 190         


Val Glu Arg Met Leu Glu Arg His Glu Arg Phe Lys Pro Glu Met Phe 
        195                 200                 205             


Ala Glu Leu Leu Gln Ala Ala Asn Thr Thr Asp Asp Tyr Arg Lys Cys 
    210                 215                 220                 


Pro Ser Asn Cys Gly Gln Lys Ile Lys Ile Arg Arg Val Leu Met Asn 
225                 230                 235                 240 


Cys Pro Glu Ile Val Thr Ile Gly Leu Val Trp Asp Ser Glu His Ser 
                245                 250                 255     


Asp Leu Thr Glu Ala Val Val Arg Asn Leu Ala Thr His Leu Tyr Leu 
            260                 265                 270         


Pro Gly Leu Phe Tyr Arg Val Thr Asp Glu Asn Ala Lys Asn Ser Glu 
        275                 280                 285             


Leu Asn Leu Val Gly Met Ile Cys Tyr Thr Ser Gln His Tyr Cys Ala 
    290                 295                 300                 


Phe Ala Phe His Thr Lys Ser Ser Lys Trp Val Phe Phe Asp Asp Ala 
305                 310                 315                 320 


Asn Val Lys Glu Ile Gly Thr Arg Trp Lys Asp Val Val Ser Lys Cys 
                325                 330                 335     


Ile Arg Cys His Phe Gln Pro Leu Leu Leu Phe Tyr Ala Asn Pro Asp 
            340                 345                 350         


Gly Thr Ala Val Ser Thr Glu Asp Ala Leu Arg Gln Val Ile Ser Trp 
        355                 360                 365             


Ser His Tyr Lys Ser Val Ala Glu Asn Met Gly Cys Glu Lys Pro Val 
    370                 375                 380                 


Ile His Lys Ser Asp Asn Leu Lys Glu Asn Gly Phe Gly Asp Gln Ala 
385                 390                 395                 400 


Lys Gln Arg Glu Asn Gln Lys Phe Pro Thr Asp Asn Ile Ser Ser Ser 
                405                 410                 415     


Asn Arg Ser His Ser His Thr Gly Val Gly Lys Gly Pro Ala Lys Leu 
            420                 425                 430         


Ser His Ile Asp Gln Arg Glu Lys Ile Lys Asp Ile Ser Arg Glu Cys 
        435                 440                 445             


Ala Leu Lys Ala Ile Glu Gln Lys Asn Leu Leu Ser Ser Gln Arg Lys 
    450                 455                 460                 


Asp Leu Glu Lys Gly Gln Arg Lys Asp Leu Gly Arg His Arg Asp Leu 
465                 470                 475                 480 


Val Asp Glu Asp Leu Ser His Phe Gln Ser Gly Ser Pro Pro Ala Pro 
                485                 490                 495     


Asn Gly Phe Lys Gln His Gly Asn Pro His Leu Tyr His Ser Gln Gly 
            500                 505                 510         


Lys Gly Ser Tyr Lys His Asp Arg Val Val Pro Gln Ser Arg Ala Ser 
        515                 520                 525             


Ala Gln Ile Ile Ser Ser Ser Lys Ser Gln Ile Leu Ala Pro Gly Glu 
    530                 535                 540                 


Lys Ile Thr Gly Lys Val Lys Ser Asp Asn Gly Thr Gly Tyr Asp Thr 
545                 550                 555                 560 


Asp Ser Ser Gln Asp Ser Arg Asp Arg Gly Asn Ser Cys Asp Ser Ser 
                565                 570                 575     


Ser Lys Ser Arg Asn Arg Gly Trp Lys Pro Met Arg Glu Thr Leu Asn 
            580                 585                 590         


Val Asp Ser Ile Phe Ser Glu Ser Glu Lys Arg Gln His Ser Pro Arg 
        595                 600                 605             


His Lys Pro Asn Ile Ser Asn Lys Pro Lys Ser Ser Lys Asp Pro Ser 
    610                 615                 620                 


Phe Ser Asn Trp Pro Lys Glu Asn Pro Lys Gln Lys Gly Leu Met Thr 
625                 630                 635                 640 


Ile Tyr Glu Asp Glu Met Lys Gln Glu Ile Gly Ser Arg Ser Ser Leu 
                645                 650                 655     


Glu Ser Asn Gly Lys Gly Ala Glu Lys Asn Lys Gly Leu Val Glu Gly 
            660                 665                 670         


Lys Val His Gly Asp Asn Trp Gln Met Gln Arg Thr Glu Ser Gly Tyr 
        675                 680                 685             


Glu Ser Ser Asp His Ile Ser Asn Gly Ser Thr Asn Leu Asp Ser Pro 
    690                 695                 700                 


Val Ile Asp Gly Asn Gly Thr Val Met Asp Ile Ser Gly Val Lys Glu 
705                 710                 715                 720 


Thr Val Cys Phe Ser Asp Gln Ile Thr Thr Ser Asn Leu Asn Lys Glu 
                725                 730                 735     


Arg Gly Asp Cys Thr Ser Leu Gln Ser Gln His His Leu Glu Gly Phe 
            740                 745                 750         


Arg Lys Glu Leu Arg Asn Leu Glu Ala Gly Tyr Lys Ser His Glu Phe 
        755                 760                 765             


His Pro Glu Ser His Leu Gln Ile Lys Asn His Leu Ile Lys Arg Ser 
    770                 775                 780                 


His Val His Glu Asp Asn Gly Lys Leu Phe Pro Ser Ser Ser Leu Gln 
785                 790                 795                 800 


Ile Pro Lys Asp His Asn Ala Arg Glu His Ile His Gln Ser Asp Glu 
                805                 810                 815     


Gln Lys Leu Glu Lys Pro Asn Glu Cys Lys Phe Ser Glu Trp Leu Asn 
            820                 825                 830         


Ile Glu Asn Ser Glu Arg Thr Gly Leu Pro Phe His Val Asp Asn Ser 
        835                 840                 845             


Ala Ser Gly Lys Arg Val Asn Ser Asn Glu Pro Ser Ser Leu Trp Ser 
    850                 855                 860                 


Ser His Leu Arg Thr Val Gly Leu Lys Pro Glu Thr Ala Pro Leu Ile 
865                 870                 875                 880 


Gln Gln Gln Asn Ile Met Asp Gln Cys Tyr Phe Glu Asn Ser Leu Ser 
                885                 890                 895     


Thr Glu Cys Ile Ile Arg Ser Ala Ser Arg Ser Asp Gly Cys Gln Met 
            900                 905                 910         


Pro Lys Leu Phe Cys Gln Asn Leu Pro Pro Pro Leu Pro Pro Lys Lys 
        915                 920                 925             


Tyr Ala Ile Thr Ser Val Pro Gln Ser Glu Lys Ser Glu Ser Thr Pro 
    930                 935                 940                 


Asp Val Lys Leu Thr Glu Val Phe Lys Ala Thr Ser His Leu Pro Lys 
945                 950                 955                 960 


His Ser Leu Ser Thr Ala Ser Glu Pro Ser Leu Glu Val Ser Thr His 
                965                 970                 975     


Met Asn Asp Glu Arg His Lys Glu Thr Phe Gln Val Arg Glu Cys Phe 
            980                 985                 990         


Gly Asn Thr Pro Asn Cys Pro Ser  Ser Ser Ser Thr Asn  Asp Phe Gln 
        995                 1000                 1005             


Ala Asn  Ser Gly Ala Ile Asp  Ala Phe Cys Gln Pro  Glu Leu Asp 
    1010                 1015                 1020             


Ser Ile  Ser Thr Cys Pro Asn  Glu Thr Val Ser Leu  Thr Thr Tyr 
    1025                 1030                 1035             


Phe Ser  Val Asp Ser Cys Met  Thr Asp Thr Tyr Arg  Leu Lys Tyr 
    1040                 1045                 1050             


His Gln  Arg Pro Lys Leu Ser  Phe Pro Glu Ser Ser  Gly Phe Cys 
    1055                 1060                 1065             


Asn Asn  Ser Leu Ser 
    1070             


<210> 57
<211> 1060
<212> PRT
<213> Homo sapiens

<400> 57
Met Glu Asp Asp Ser Leu Tyr Leu Arg Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Ser Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe 
    530                 535                 540                 


Asn His Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala 
545                 550                 555                 560 


Glu Ile Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu 
                565                 570                 575     


Thr Arg Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu 
            580                 585                 590         


Ala Pro Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val 
        595                 600                 605             


Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser 
    610                 615                 620                 


Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser 
625                 630                 635                 640 


Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys 
                645                 650                 655     


Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val 
            660                 665                 670         


Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln 
        675                 680                 685             


Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys 
    690                 695                 700                 


Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr 
705                 710                 715                 720 


Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys 
                725                 730                 735     


Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp 
            740                 745                 750         


Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu 
        755                 760                 765             


Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys 
    770                 775                 780                 


Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His 
785                 790                 795                 800 


Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val 
                805                 810                 815     


Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp 
            820                 825                 830         


Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val 
        835                 840                 845             


Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His 
    850                 855                 860                 


Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp 
865                 870                 875                 880 


Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln 
                885                 890                 895     


Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser 
            900                 905                 910         


Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp 
        915                 920                 925             


Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys 
    930                 935                 940                 


Leu Gln Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln 
945                 950                 955                 960 


Glu Ser Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr 
                965                 970                 975     


Lys Pro Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp 
            980                 985                 990         


Val Leu Val Ile His Gln Ser Lys  Tyr Lys Cys Gly Met  Lys Asn His 
        995                 1000                 1005             


His Pro  Glu Gln Gln Ser Ser  Leu Leu Lys Leu Ser  Ser Thr Thr 
    1010                 1015                 1020             


Pro Thr  His Gln Glu Ser Met  Asn Thr Gly Thr Leu  Ala Ser Leu 
    1025                 1030                 1035             


Arg Gly  Arg Ala Arg Arg Ser  Lys Gly Lys Asn Lys  His Ser Lys 
    1040                 1045                 1050             


Arg Ala  Leu Leu Val Cys Gln  
    1055                 1060 


<210> 58
<211> 858
<212> PRT
<213> Homo sapiens

<400> 58
Met Ala Glu Leu Ser Glu Glu Ala Leu Leu Ser Val Leu Pro Thr Ile 
1               5                   10                  15      


Arg Val Pro Lys Ala Gly Asp Arg Val His Lys Asp Glu Cys Ala Phe 
            20                  25                  30          


Ser Phe Asp Thr Pro Glu Ser Glu Gly Gly Leu Tyr Ile Cys Met Asn 
        35                  40                  45              


Thr Phe Leu Gly Phe Gly Lys Gln Tyr Val Glu Arg His Phe Asn Lys 
    50                  55                  60                  


Thr Gly Gln Arg Val Tyr Leu His Leu Arg Arg Thr Arg Arg Pro Lys 
65                  70                  75                  80  


Glu Glu Asp Pro Ala Thr Gly Thr Gly Asp Pro Pro Arg Lys Lys Pro 
                85                  90                  95      


Thr Arg Leu Ala Ile Gly Val Glu Gly Gly Phe Asp Leu Ser Glu Glu 
            100                 105                 110         


Lys Phe Glu Leu Asp Glu Asp Val Lys Ile Val Ile Leu Pro Asp Tyr 
        115                 120                 125             


Leu Glu Ile Ala Arg Asp Gly Leu Gly Gly Leu Pro Asp Ile Val Arg 
    130                 135                 140                 


Asp Arg Val Thr Ser Ala Val Glu Ala Leu Leu Ser Ala Asp Ser Ala 
145                 150                 155                 160 


Ser Arg Lys Gln Glu Val Gln Ala Trp Asp Gly Glu Val Arg Gln Val 
                165                 170                 175     


Ser Lys His Ala Phe Ser Leu Lys Gln Leu Asp Asn Pro Ala Arg Ile 
            180                 185                 190         


Pro Pro Cys Gly Trp Lys Cys Ser Lys Cys Asp Met Arg Glu Asn Leu 
        195                 200                 205             


Trp Leu Asn Leu Thr Asp Gly Ser Ile Leu Cys Gly Arg Arg Tyr Phe 
    210                 215                 220                 


Asp Gly Ser Gly Gly Asn Asn His Ala Val Glu His Tyr Arg Glu Thr 
225                 230                 235                 240 


Gly Tyr Pro Leu Ala Val Lys Leu Gly Thr Ile Thr Pro Asp Gly Ala 
                245                 250                 255     


Asp Val Tyr Ser Tyr Asp Glu Asp Asp Met Val Leu Asp Pro Ser Leu 
            260                 265                 270         


Ala Glu His Leu Ser His Phe Gly Ile Asp Met Leu Lys Met Gln Lys 
        275                 280                 285             


Thr Asp Lys Thr Met Thr Glu Leu Glu Ile Asp Met Asn Gln Arg Ile 
    290                 295                 300                 


Gly Glu Trp Glu Leu Ile Gln Glu Ser Gly Val Pro Leu Lys Pro Leu 
305                 310                 315                 320 


Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
                325                 330                 335     


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            340                 345                 350         


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        355                 360                 365             


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    370                 375                 380                 


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
385                 390                 395                 400 


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                405                 410                 415     


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            420                 425                 430         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        435                 440                 445             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    450                 455                 460                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
465                 470                 475                 480 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                485                 490                 495     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            500                 505                 510         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        515                 520                 525             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    530                 535                 540                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
545                 550                 555                 560 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                565                 570                 575     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            580                 585                 590         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        595                 600                 605             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    610                 615                 620                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
625                 630                 635                 640 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                645                 650                 655     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            660                 665                 670         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        675                 680                 685             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    690                 695                 700                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
705                 710                 715                 720 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                725                 730                 735     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            740                 745                 750         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        755                 760                 765             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    770                 775                 780                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
785                 790                 795                 800 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                805                 810                 815     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            820                 825                 830         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        835                 840                 845             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Ser 
    850                 855             


<210> 59
<211> 1055
<212> PRT
<213> Homo sapiens

<400> 59
Met Thr Val Glu Gln Asn Val Leu Gln Gln Ser Ala Ala Gln Lys His 
1               5                   10                  15      


Gln Gln Thr Phe Leu Asn Gln Leu Arg Glu Ile Thr Gly Ile Asn Asp 
            20                  25                  30          


Thr Gln Ile Leu Gln Gln Ala Leu Lys Asp Ser Asn Gly Asn Leu Glu 
        35                  40                  45              


Leu Ala Val Ala Phe Leu Thr Ala Lys Asn Ala Lys Thr Pro Gln Gln 
    50                  55                  60                  


Glu Glu Thr Thr Tyr Tyr Gln Thr Ala Leu Pro Gly Asn Asp Arg Tyr 
65                  70                  75                  80  


Ile Ser Val Gly Ser Gln Ala Asp Thr Asn Val Ile Asp Leu Thr Gly 
                85                  90                  95      


Asp Asp Lys Asp Asp Leu Gln Arg Ala Ile Ala Leu Ser Leu Ala Glu 
            100                 105                 110         


Ser Asn Arg Ala Phe Arg Glu Thr Gly Ile Thr Asp Glu Glu Gln Ala 
        115                 120                 125             


Ile Ser Arg Val Leu Glu Ala Ser Ile Ala Glu Asn Lys Ala Cys Leu 
    130                 135                 140                 


Lys Arg Thr Pro Thr Glu Val Trp Arg Asp Ser Arg Asn Pro Tyr Asp 
145                 150                 155                 160 


Arg Lys Arg Gln Asp Lys Ala Pro Val Gly Leu Lys Asn Val Gly Asn 
                165                 170                 175     


Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe Asn Leu Leu Glu 
            180                 185                 190         


Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser Asn Ala Gln Asp 
        195                 200                 205             


Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro Phe Met Arg Glu 
    210                 215                 220                 


Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys Arg Lys Tyr Val 
225                 230                 235                 240 


Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala Phe Lys Ser Asn 
                245                 250                 255     


Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp 
            260                 265                 270         


Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu Glu Thr Asp Glu 
        275                 280                 285             


Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr Gly Arg Phe Leu 
    290                 295                 300                 


Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn Thr Glu Met Phe 
305                 310                 315                 320 


Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp Leu His Glu Cys 
                325                 330                 335     


Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser Leu His Ser Glu 
            340                 345                 350         


Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr Glu Leu Pro Pro 
        355                 360                 365             


Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn Gln Ala Leu Gly 
    370                 375                 380                 


Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro Gln Val Leu Tyr 
385                 390                 395                 400 


Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr Arg Ile Lys Arg 
                405                 410                 415     


Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val Leu Gln Gln Arg 
            420                 425                 430         


Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys Arg Phe Pro Leu 
        435                 440                 445             


Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser Ser Lys Pro Val 
    450                 455                 460                 


Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser Pro Pro Ser Gly 
465                 470                 475                 480 


Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu Gln Gln Gly Ala 
                485                 490                 495     


Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser Val Ala Ala Ile 
            500                 505                 510         


Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln Ser Arg Ile Pro 
        515                 520                 525             


Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile Thr Glu Glu Glu 
    530                 535                 540                 


Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg Thr Glu Ile Glu 
545                 550                 555                 560 


Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg Ile His Arg Thr 
                565                 570                 575     


Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln Val Pro Tyr Arg 
            580                 585                 590         


Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn Ala Gly His Tyr 
        595                 600                 605             


Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp Met Lys Tyr Asn 
    610                 615                 620                 


Asp Ile Ala Val Thr Lys Ser Ser Trp Glu Glu Leu Val Arg Asp Ser 
625                 630                 635                 640 


Phe Gly Gly Tyr Arg Asn Ala Ser Ala Tyr Cys Leu Met Tyr Ile Asn 
                645                 650                 655     


Asp Lys Ala Gln Phe Leu Ile Gln Glu Glu Phe Asn Lys Glu Thr Gly 
            660                 665                 670         


Gln Pro Leu Val Gly Ile Glu Thr Leu Pro Pro Asp Leu Arg Asp Phe 
        675                 680                 685             


Val Glu Glu Asp Asn Gln Arg Phe Glu Lys Glu Leu Glu Glu Trp Asp 
    690                 695                 700                 


Ala Gln Leu Ala Gln Lys Ala Leu Gln Glu Lys Leu Leu Ala Ser Gln 
705                 710                 715                 720 


Lys Leu Arg Glu Ser Glu Thr Ser Val Thr Thr Ala Gln Ala Ala Gly 
                725                 730                 735     


Asp Pro Glu Tyr Leu Glu Gln Pro Ser Arg Ser Asp Phe Ser Lys His 
            740                 745                 750         


Leu Lys Glu Glu Thr Ile Gln Ile Ile Thr Lys Ala Ser His Glu His 
        755                 760                 765             


Glu Asp Lys Ser Pro Glu Thr Val Leu Gln Ser Ala Ile Lys Leu Glu 
    770                 775                 780                 


Tyr Ala Arg Leu Val Lys Leu Ala Gln Glu Asp Thr Pro Pro Glu Thr 
785                 790                 795                 800 


Asp Tyr Arg Leu His His Val Val Val Tyr Phe Ile Gln Asn Gln Ala 
                805                 810                 815     


Pro Lys Lys Ile Ile Glu Lys Thr Leu Leu Glu Gln Phe Gly Asp Arg 
            820                 825                 830         


Asn Leu Ser Phe Asp Glu Arg Cys His Asn Ile Met Lys Val Ala Gln 
        835                 840                 845             


Ala Lys Leu Glu Met Ile Lys Pro Glu Glu Val Asn Leu Glu Glu Tyr 
    850                 855                 860                 


Glu Glu Trp His Gln Asp Tyr Arg Lys Phe Arg Glu Thr Thr Met Tyr 
865                 870                 875                 880 


Leu Ile Ile Gly Leu Glu Asn Phe Gln Arg Glu Ser Tyr Ile Asp Ser 
                885                 890                 895     


Leu Leu Phe Leu Ile Cys Ala Tyr Gln Asn Asn Lys Glu Leu Leu Ser 
            900                 905                 910         


Lys Gly Leu Tyr Arg Gly His Asp Glu Glu Leu Ile Ser His Tyr Arg 
        915                 920                 925             


Arg Glu Cys Leu Leu Lys Leu Asn Glu Gln Ala Ala Glu Leu Phe Glu 
    930                 935                 940                 


Ser Gly Glu Asp Arg Glu Val Asn Asn Gly Leu Ile Ile Met Asn Glu 
945                 950                 955                 960 


Phe Ile Val Pro Phe Leu Pro Leu Leu Leu Val Asp Glu Met Glu Glu 
                965                 970                 975     


Lys Asp Ile Leu Ala Val Glu Asp Met Arg Asn Arg Trp Cys Ser Tyr 
            980                 985                 990         


Leu Gly Gln Glu Met Glu Pro His  Leu Gln Glu Lys Leu  Thr Asp Phe 
        995                 1000                 1005             


Leu Pro  Lys Leu Leu Asp Cys  Ser Met Glu Ile Lys  Ser Phe His 
    1010                 1015                 1020             


Glu Pro  Pro Lys Leu Pro Ser  Tyr Ser Thr His Glu  Leu Cys Glu 
    1025                 1030                 1035             


Arg Phe  Ala Arg Ile Met Leu  Ser Leu Ser Arg Thr  Pro Ala Asp 
    1040                 1045                 1050             


Gly Arg  
    1055 


<210> 60
<211> 942
<212> PRT
<213> Homo sapiens

<400> 60
Met Thr Gly Ser Asn Ser His Ile Thr Ile Leu Thr Leu Lys Val Leu 
1               5                   10                  15      


Pro His Phe Glu Ser Leu Gly Lys Gln Glu Lys Ile Pro Asn Lys Met 
            20                  25                  30          


Ser Ala Phe Arg Asn His Cys Pro His Leu Asp Ser Val Gly Glu Ile 
        35                  40                  45              


Thr Lys Glu Asp Leu Ile Gln Lys Ser Leu Gly Thr Cys Gln Asp Cys 
    50                  55                  60                  


Lys Val Gln Gly Pro Asn Leu Trp Ala Cys Leu Glu Asn Arg Cys Ser 
65                  70                  75                  80  


Tyr Val Gly Cys Gly Glu Ser Gln Val Asp His Ser Thr Ile His Ser 
                85                  90                  95      


Gln Glu Thr Lys His Tyr Leu Thr Val Asn Leu Thr Thr Leu Arg Val 
            100                 105                 110         


Trp Cys Tyr Ala Cys Ser Lys Glu Val Phe Leu Asp Arg Lys Leu Gly 
        115                 120                 125             


Thr Gln Pro Ser Leu Pro His Val Arg Gln Pro His Gln Ile Gln Glu 
    130                 135                 140                 


Asn Ser Val Gln Asp Phe Lys Ile Pro Ser Asn Thr Thr Leu Lys Thr 
145                 150                 155                 160 


Pro Leu Val Ala Val Phe Asp Asp Leu Asp Ile Glu Ala Asp Glu Glu 
                165                 170                 175     


Asp Glu Leu Arg Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn 
            180                 185                 190         


Thr Cys Tyr Met Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro 
        195                 200                 205             


Leu Thr Gln Phe Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys 
    210                 215                 220                 


Lys Pro Ala Ile Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp 
225                 230                 235                 240 


His Lys Ser Arg Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly 
                245                 250                 255     


Ile Lys Thr Val Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala 
            260                 265                 270         


Gln Glu Phe Leu Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys 
        275                 280                 285             


Glu Gln Val Met Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu 
    290                 295                 300                 


Glu Thr Met Glu Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser 
305                 310                 315                 320 


Cys Glu Ser Cys Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser 
                325                 330                 335     


Arg Cys Phe Ser Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp 
            340                 345                 350         


Asp Glu Asn Asn Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met 
        355                 360                 365             


Cys Asn Lys Ile Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp 
    370                 375                 380                 


Arg Asp Ser Ile Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val 
385                 390                 395                 400 


Lys Val Gln Ile His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His 
                405                 410                 415     


Ser Asn Asp Leu Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val 
            420                 425                 430         


Asn Pro Arg Leu Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro 
        435                 440                 445             


Gly Leu Ala Pro Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg 
    450                 455                 460                 


Lys Lys Gln His Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp 
465                 470                 475                 480 


Gly Thr Ile Ile Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser 
                485                 490                 495     


Val Thr Leu Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys 
            500                 505                 510         


Glu Asp Leu Ala Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val 
        515                 520                 525             


Lys Ala Gly Ser Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala 
    530                 535                 540                 


Phe Phe Met Glu Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro Ser 
545                 550                 555                 560 


Trp Phe Trp Gly Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala Phe 
                565                 570                 575     


Phe Ala Arg Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu Lys 
            580                 585                 590         


Cys Lys Lys Leu Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn Phe 
        595                 600                 605             


Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu Leu Met 
    610                 615                 620                 


Phe Ser Thr Lys Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly Leu 
625                 630                 635                 640 


Asp Leu Gln Pro Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val Thr 
                645                 650                 655     


Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Ser Ser Gly 
            660                 665                 670         


His Tyr Ile Ala Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr Glu 
        675                 680                 685             


Phe Asp Asp Gln Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln Asn 
    690                 695                 700                 


Ala Glu Ala Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu Ala Gln 
705                 710                 715                 720 


Lys Glu Arg Arg Arg Ile Ser Asn Leu Leu Asn Ile Met Glu Pro Ser 
                725                 730                 735     


Leu Leu Gln Phe Tyr Ile Ser Arg Gln Trp Leu Asn Lys Phe Lys Thr 
            740                 745                 750         


Phe Ala Glu Pro Gly Pro Ile Ser Asn Asn Asp Phe Leu Cys Ile His 
        755                 760                 765             


Gly Gly Val Pro Pro Arg Lys Ala Gly Tyr Ile Glu Asp Leu Val Leu 
    770                 775                 780                 


Met Leu Pro Gln Asn Ile Trp Asp Asn Leu Tyr Ser Arg Tyr Gly Gly 
785                 790                 795                 800 


Gly Pro Ala Val Asn His Leu Tyr Ile Cys His Thr Cys Gln Ile Glu 
                805                 810                 815     


Ala Glu Lys Ile Glu Lys Arg Arg Lys Thr Glu Leu Glu Ile Phe Ile 
            820                 825                 830         


Arg Leu Asn Arg Ala Phe Gln Lys Glu Asp Ser Pro Ala Thr Phe Tyr 
        835                 840                 845             


Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ser Phe Val Lys Gly 
    850                 855                 860                 


Lys Asp Gly Asp Pro Pro Gly Pro Ile Asp Asn Thr Lys Ile Ala Val 
865                 870                 875                 880 


Thr Lys Cys Gly Asn Val Met Leu Arg Gln Gly Ala Asp Ser Gly Gln 
                885                 890                 895     


Ile Ser Glu Glu Thr Trp Asn Phe Leu Gln Ser Ile Tyr Gly Gly Gly 
            900                 905                 910         


Pro Glu Val Ile Leu Arg Pro Pro Val Val His Val Asp Pro Asp Ile 
        915                 920                 925             


Leu Gln Ala Glu Glu Lys Ile Glu Val Glu Thr Arg Ser Leu 
    930                 935                 940         


<210> 61
<211> 565
<212> PRT
<213> Homo sapiens

<400> 61
Met Pro Gln Ala Ser Glu His Arg Leu Gly Arg Thr Arg Glu Pro Pro 
1               5                   10                  15      


Val Asn Ile Gln Pro Arg Val Gly Ser Lys Leu Pro Phe Ala Pro Arg 
            20                  25                  30          


Ala Arg Ser Lys Glu Arg Arg Asn Pro Ala Ser Gly Pro Asn Pro Met 
        35                  40                  45              


Leu Arg Pro Leu Pro Pro Arg Pro Gly Leu Pro Asp Glu Arg Leu Lys 
    50                  55                  60                  


Lys Leu Glu Leu Gly Arg Gly Arg Thr Ser Gly Pro Arg Pro Arg Gly 
65                  70                  75                  80  


Pro Leu Arg Ala Asp His Gly Val Pro Leu Pro Gly Ser Pro Pro Pro 
                85                  90                  95      


Thr Val Ala Leu Pro Leu Pro Ser Arg Thr Asn Leu Ala Arg Ser Lys 
            100                 105                 110         


Ser Val Ser Ser Gly Asp Leu Arg Pro Met Gly Ile Ala Leu Gly Gly 
        115                 120                 125             


His Arg Gly Thr Gly Glu Leu Gly Ala Ala Leu Ser Arg Leu Ala Leu 
    130                 135                 140                 


Arg Pro Glu Pro Pro Thr Leu Arg Arg Ser Thr Ser Leu Arg Arg Leu 
145                 150                 155                 160 


Gly Gly Phe Pro Gly Pro Pro Thr Leu Phe Ser Ile Arg Thr Glu Pro 
                165                 170                 175     


Pro Ala Ser His Gly Ser Phe His Met Ile Ser Ala Arg Ser Ser Glu 
            180                 185                 190         


Pro Phe Tyr Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly 
        195                 200                 205             


Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn 
    210                 215                 220                 


Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys 
225                 230                 235                 240 


Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln 
                245                 250                 255     


Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro 
            260                 265                 270         


Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln 
        275                 280                 285             


Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu 
    290                 295                 300                 


Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg 
305                 310                 315                 320 


Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro 
                325                 330                 335     


Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp 
            340                 345                 350         


Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser 
        355                 360                 365             


Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys 
    370                 375                 380                 


Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu 
385                 390                 395                 400 


Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu 
                405                 410                 415     


Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu 
            420                 425                 430         


Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys 
        435                 440                 445             


Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn 
    450                 455                 460                 


Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val 
465                 470                 475                 480 


Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys 
                485                 490                 495     


Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly 
            500                 505                 510         


Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly 
        515                 520                 525             


Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln 
    530                 535                 540                 


Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu 
545                 550                 555                 560 


Pro Pro Arg Cys Leu 
                565 


<210> 62
<211> 530
<212> PRT
<213> Homo sapiens

<400> 62
Met Gly Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Ser Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Leu 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Ala Gly 
        275                 280                 285             


Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp Gly Tyr Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Val Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Glu Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Pro Gln Glu Gln Asn Lys Met Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asn Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Met Asn Ser Thr Asp 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Gln Gly Arg Thr 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ser Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 63
<211> 530
<212> PRT
<213> Homo sapiens

<400> 63
Met Glu Asp Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Ser Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Asn Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 64
<211> 370
<212> PRT
<213> Homo sapiens

<400> 64
Met Glu Ile Leu Met Thr Val Ser Lys Phe Ala Ser Ile Cys Thr Met 
1               5                   10                  15      


Gly Ala Asn Ala Ser Ala Leu Glu Lys Glu Ile Gly Pro Glu Gln Phe 
            20                  25                  30          


Pro Val Asn Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys 
        35                  40                  45              


Tyr Cys Asn Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg 
    50                  55                  60                  


Glu Lys Val Leu Ala Tyr Lys Ser Gln Pro Arg Lys Lys Glu Ser Leu 
65                  70                  75                  80  


Leu Thr Cys Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys 
                85                  90                  95      


Lys Val Gly Val Ile Pro Pro Lys Lys Phe Ile Thr Arg Leu Arg Lys 
            100                 105                 110         


Glu Asn Glu Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe 
        115                 120                 125             


Leu Asn Tyr Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Arg 
    130                 135                 140                 


Lys Gln Glu Lys Gln Asn Gly Arg Leu Pro Asn Gly Asn Ile Asp Asn 
145                 150                 155                 160 


Glu Asn Asn Asn Ser Thr Pro Asp Pro Thr Trp Val His Glu Ile Phe 
                165                 170                 175     


Gln Gly Thr Leu Thr Asn Glu Thr Arg Cys Leu Thr Cys Glu Thr Ile 
            180                 185                 190         


Ser Ser Lys Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln 
        195                 200                 205             


Asn Thr Ser Ile Thr His Cys Leu Arg Gly Phe Ser Asn Thr Glu Thr 
    210                 215                 220                 


Leu Cys Ser Glu Tyr Lys Tyr Tyr Cys Glu Glu Cys Arg Ser Lys Gln 
225                 230                 235                 240 


Glu Ala His Lys Arg Met Lys Val Lys Lys Leu Pro Met Ile Leu Ala 
                245                 250                 255     


Leu His Leu Lys Arg Phe Lys Tyr Met Asp Gln Leu His Arg Tyr Thr 
            260                 265                 270         


Lys Leu Ser Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn 
        275                 280                 285             


Thr Ser Gly Asp Ala Thr Asn Pro Asp Arg Met Tyr Asp Leu Val Ala 
    290                 295                 300                 


Val Val Val His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Ala 
305                 310                 315                 320 


Ile Val Lys Ser His Asp Phe Trp Leu Leu Phe Asp Asp Asp Ile Val 
                325                 330                 335     


Glu Lys Ile Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser 
            340                 345                 350         


Asp Ile Ser Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser 
        355                 360                 365             


Arg Asp 
    370 


<210> 65
<211> 530
<212> PRT
<213> Homo sapiens

<400> 65
Met Glu Glu Asp Ser Leu Tyr Leu Gly Gly Glu Trp Gln Phe Asn His 
1               5                   10                  15      


Phe Ser Lys Leu Thr Ser Ser Arg Pro Asp Ala Ala Phe Ala Glu Ile 
            20                  25                  30          


Gln Arg Thr Ser Leu Pro Glu Lys Ser Pro Leu Ser Cys Glu Thr Arg 
        35                  40                  45              


Val Asp Leu Cys Asp Asp Leu Ala Pro Val Ala Arg Gln Leu Ala Pro 
    50                  55                  60                  


Arg Glu Lys Leu Pro Leu Ser Asn Arg Arg Pro Ala Ala Val Gly Ala 
65                  70                  75                  80  


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
                85                  90                  95      


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
            100                 105                 110         


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
        115                 120                 125             


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
    130                 135                 140                 


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
145                 150                 155                 160 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
                165                 170                 175     


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
            180                 185                 190         


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
        195                 200                 205             


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
    210                 215                 220                 


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
225                 230                 235                 240 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
                245                 250                 255     


Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr Leu Leu Thr Ser 
            260                 265                 270         


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
        275                 280                 285             


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
    290                 295                 300                 


Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
305                 310                 315                 320 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
                325                 330                 335     


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
            340                 345                 350         


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
        355                 360                 365             


Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg His Ser Glu Ser 
    370                 375                 380                 


Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala Glu Asp Thr Asp 
385                 390                 395                 400 


Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His Pro Cys Leu Gln 
                405                 410                 415     


Ala Pro Glu Leu Asp Glu His Leu Val Glu Arg Ala Thr Gln Glu Ser 
            420                 425                 430         


Thr Leu Asp His Trp Lys Phe Leu Gln Glu Gln Asn Lys Thr Lys Pro 
        435                 440                 445             


Glu Phe Asn Val Arg Lys Val Glu Gly Thr Leu Pro Pro Asp Val Leu 
    450                 455                 460                 


Val Ile His Gln Ser Lys Tyr Lys Cys Gly Met Lys Asn His His Pro 
465                 470                 475                 480 


Glu Gln Gln Ser Ser Leu Leu Lys Leu Ser Ser Thr Thr Pro Thr His 
                485                 490                 495     


Gln Glu Ser Met Asn Thr Gly Thr Leu Ala Ser Leu Arg Gly Arg Ala 
            500                 505                 510         


Arg Arg Ser Lys Gly Lys Asn Lys His Ser Lys Arg Ala Leu Leu Val 
        515                 520                 525             


Cys Gln 
    530 


<210> 66
<211> 914
<212> PRT
<213> Homo sapiens

<400> 66
Met Gly Asp Ser Arg Asp Leu Cys Pro His Leu Asp Ser Ile Gly Glu 
1               5                   10                  15      


Val Thr Lys Glu Asp Leu Leu Leu Lys Ser Lys Gly Thr Cys Gln Ser 
            20                  25                  30          


Cys Gly Val Thr Gly Pro Asn Leu Trp Ala Cys Leu Gln Val Ala Cys 
        35                  40                  45              


Pro Tyr Val Gly Cys Gly Glu Ser Phe Ala Asp His Ser Thr Ile His 
    50                  55                  60                  


Ala Gln Ala Lys Lys His Asn Leu Thr Val Asn Leu Thr Thr Phe Arg 
65                  70                  75                  80  


Leu Trp Cys Tyr Ala Cys Glu Lys Glu Val Phe Leu Glu Gln Arg Leu 
                85                  90                  95      


Ala Ala Pro Leu Leu Gly Ser Ser Ser Lys Phe Ser Glu Gln Asp Ser 
            100                 105                 110         


Pro Pro Pro Ser His Pro Leu Lys Ala Val Pro Ile Ala Val Ala Asp 
        115                 120                 125             


Glu Gly Glu Ser Glu Ser Glu Asp Asp Asp Leu Lys Pro Arg Gly Leu 
    130                 135                 140                 


Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met Asn Ala Ala Leu 
145                 150                 155                 160 


Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe Phe Leu Glu Cys 
                165                 170                 175     


Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu Cys Lys Ser Tyr 
            180                 185                 190         


Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg Pro Ser Tyr Val 
        195                 200                 205             


Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val Asn Pro Met Phe 
    210                 215                 220                 


Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu Arg Cys Leu Met 
225                 230                 235                 240 


Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val Ala Thr Val Ala 
                245                 250                 255     


Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr Asp Glu Lys Arg 
            260                 265                 270         


Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu Ser Cys Asp Ser 
        275                 280                 285             


Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg Gly Gly Gly Ser 
    290                 295                 300                 


Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu Ala Gly Arg Ala 
305                 310                 315                 320 


Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe Ser Trp Gly Gln 
                325                 330                 335     


Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala Asp Val Asp Thr 
            340                 345                 350         


Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala Gln Pro Pro Ser 
        355                 360                 365             


Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro Asp Asn Asp Ala 
    370                 375                 380                 


His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val His His His Glu 
385                 390                 395                 400 


Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala Ser Pro Val Arg 
                405                 410                 415     


Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val Leu Ser Ala Gly 
            420                 425                 430         


Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val Ile Ser Asp Ile 
        435                 440                 445             


Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu Thr Cys Asp Arg 
    450                 455                 460                 


Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro 
465                 470                 475                 480 


Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile Tyr Gln Asn Val 
                485                 490                 495     


Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala Ala Gln Gly Trp 
            500                 505                 510         


Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val Val Ser Cys Thr 
        515                 520                 525             


Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu Asp Cys Leu Ala 
    530                 535                 540                 


Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys 
545                 550                 555                 560 


Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr Cys Lys Val Leu 
                565                 570                 575     


Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg Phe Arg His Glu 
            580                 585                 590         


Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser Phe Pro Leu Glu 
        595                 600                 605             


Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys Thr Ser Gln Ile 
    610                 615                 620                 


Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His Gly Thr Ala Gly 
625                 630                 635                 640 


Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile Asn Gly Gln Trp 
                645                 650                 655     


Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His Glu Thr Val Val 
            660                 665                 670         


Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys Ser Ser Glu Glu 
        675                 680                 685             


Ala Met Arg Glu Arg Gln Gln Val Val Ser Leu Ala Ala Met Arg Glu 
    690                 695                 700                 


Pro Ser Leu Leu Arg Phe Tyr Val Ser Arg Glu Trp Leu Asn Lys Phe 
705                 710                 715                 720 


Asn Thr Phe Ala Glu Pro Gly Pro Ile Thr Asn Gln Thr Phe Leu Cys 
                725                 730                 735     


Ser His Gly Gly Ile Pro Pro His Lys Tyr His Tyr Ile Asp Asp Leu 
            740                 745                 750         


Val Val Ile Leu Pro Gln Asn Val Trp Glu His Leu Tyr Asn Arg Phe 
        755                 760                 765             


Gly Gly Gly Pro Ala Val Asn His Leu Tyr Val Cys Ser Ile Cys Gln 
    770                 775                 780                 


Val Glu Ile Glu Ala Leu Ala Lys Arg Arg Arg Ile Glu Ile Asp Thr 
785                 790                 795                 800 


Phe Ile Lys Leu Asn Lys Ala Phe Gln Ala Glu Glu Ser Pro Gly Val 
                805                 810                 815     


Ile Tyr Cys Ile Ser Met Gln Trp Phe Arg Glu Trp Glu Ala Phe Val 
            820                 825                 830         


Lys Gly Lys Asp Asn Glu Pro Pro Gly Pro Ile Asp Asn Ser Arg Ile 
        835                 840                 845             


Ala Gln Val Lys Gly Ser Gly His Val Gln Leu Lys Gln Gly Ala Asp 
    850                 855                 860                 


Tyr Gly Gln Ile Ser Glu Glu Thr Trp Thr Tyr Leu Asn Ser Leu Tyr 
865                 870                 875                 880 


Gly Gly Gly Pro Glu Ile Ala Ile Arg Gln Ser Val Ala Gln Pro Leu 
                885                 890                 895     


Gly Pro Glu Asn Leu His Gly Glu Gln Lys Ile Glu Ala Glu Thr Arg 
            900                 905                 910         


Ala Val 
        


<210> 67
<211> 366
<212> PRT
<213> Homo sapiens

<400> 67
Met Thr Val Arg Asn Ile Ala Ser Ile Cys Asn Met Gly Thr Asn Ala 
1               5                   10                  15      


Ser Ala Leu Glu Lys Asp Ile Gly Pro Glu Gln Phe Pro Ile Asn Glu 
            20                  25                  30          


His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn Ser 
        35                  40                  45              


Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Asn Val Leu 
    50                  55                  60                  


Ala Tyr Lys Ala Gln Gln Lys Lys Lys Glu Asn Leu Leu Thr Cys Leu 
65                  70                  75                  80  


Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly Val 
                85                  90                  95      


Ile Pro Pro Lys Lys Phe Ile Ser Arg Leu Arg Lys Glu Asn Asp Leu 
            100                 105                 110         


Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr Leu 
        115                 120                 125             


Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Lys Lys Gln Glu Lys 
    130                 135                 140                 


Gln Asn Gly Lys Leu Lys Asn Gly Asn Met Asn Glu Pro Ala Glu Asn 
145                 150                 155                 160 


Asn Lys Pro Glu Leu Thr Trp Val His Glu Ile Phe Gln Gly Thr Leu 
                165                 170                 175     


Thr Asn Glu Thr Arg Cys Leu Asn Cys Glu Thr Val Ser Ser Lys Asp 
            180                 185                 190         


Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser Ile 
        195                 200                 205             


Thr His Cys Leu Arg Asp Phe Ser Asn Thr Glu Thr Leu Cys Ser Glu 
    210                 215                 220                 


Gln Lys Tyr Tyr Cys Glu Thr Cys Cys Ser Lys Gln Glu Ala Gln Lys 
225                 230                 235                 240 


Arg Met Arg Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu Lys 
                245                 250                 255     


Arg Phe Lys Tyr Met Glu Gln Leu His Arg Tyr Thr Lys Leu Ser Tyr 
            260                 265                 270         


Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Ser Asp 
        275                 280                 285             


Ala Val Asn Leu Asp Arg Met Tyr Asp Leu Val Ala Val Val Val His 
    290                 295                 300                 


Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Thr Ile Val Lys Ser 
305                 310                 315                 320 


His Gly Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile Asp 
                325                 330                 335     


Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser Lys 
            340                 345                 350         


Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg Glu 
        355                 360                 365     


<210> 68
<211> 956
<212> PRT
<213> Homo sapiens

<400> 68
Met Ser Ser Gly Leu Trp Ser Gln Glu Lys Val Thr Ser Pro Tyr Trp 
1               5                   10                  15      


Glu Glu Arg Ile Phe Tyr Leu Leu Leu Gln Glu Cys Ser Val Thr Asp 
            20                  25                  30          


Lys Gln Thr Gln Lys Leu Leu Lys Val Pro Lys Gly Ser Ile Gly Gln 
        35                  40                  45              


Tyr Ile Gln Asp Arg Ser Val Gly His Ser Arg Ile Pro Ser Ala Lys 
    50                  55                  60                  


Gly Lys Lys Asn Gln Ile Gly Leu Lys Ile Leu Glu Gln Pro His Ala 
65                  70                  75                  80  


Val Leu Phe Val Asp Glu Lys Asp Val Val Glu Ile Asn Glu Lys Phe 
                85                  90                  95      


Thr Glu Leu Leu Leu Ala Ile Thr Asn Cys Glu Glu Arg Phe Ser Leu 
            100                 105                 110         


Phe Lys Asn Arg Asn Arg Leu Ser Lys Gly Leu Gln Ile Asp Val Gly 
        115                 120                 125             


Cys Pro Val Lys Val Gln Leu Arg Ser Gly Glu Glu Lys Phe Pro Gly 
    130                 135                 140                 


Val Val Arg Phe Arg Gly Pro Leu Leu Ala Glu Arg Thr Val Ser Gly 
145                 150                 155                 160 


Ile Phe Phe Gly Val Glu Leu Leu Glu Glu Gly Arg Gly Gln Gly Phe 
                165                 170                 175     


Thr Asp Gly Val Tyr Gln Gly Lys Gln Leu Phe Gln Cys Asp Glu Asp 
            180                 185                 190         


Cys Gly Val Phe Val Ala Leu Asp Lys Leu Glu Leu Ile Glu Asp Asp 
        195                 200                 205             


Asp Thr Ala Leu Glu Ser Asp Tyr Ala Gly Pro Gly Asp Thr Met Gln 
    210                 215                 220                 


Val Glu Leu Pro Pro Leu Glu Ile Asn Ser Arg Val Ser Leu Lys Val 
225                 230                 235                 240 


Gly Glu Thr Ile Glu Ser Gly Thr Val Ile Phe Cys Asp Val Leu Pro 
                245                 250                 255     


Gly Lys Glu Ser Leu Gly Tyr Phe Val Gly Val Asp Met Asp Asn Pro 
            260                 265                 270         


Ile Gly Asn Trp Asp Gly Arg Phe Asp Gly Val Gln Leu Cys Ser Phe 
        275                 280                 285             


Ala Cys Val Glu Ser Thr Ile Leu Leu His Ile Asn Asp Ile Ile Pro 
    290                 295                 300                 


Ala Leu Ser Glu Ser Val Thr Gln Glu Arg Arg Pro Pro Lys Leu Ala 
305                 310                 315                 320 


Phe Met Ser Arg Gly Val Gly Asp Lys Gly Ser Ser Ser His Asn Lys 
                325                 330                 335     


Pro Lys Ala Thr Gly Ser Thr Ser Asp Pro Gly Asn Arg Asn Arg Ser 
            340                 345                 350         


Glu Leu Phe Tyr Thr Leu Asn Gly Ser Ser Val Asp Ser Gln Pro Gln 
        355                 360                 365             


Ser Lys Ser Lys Asn Thr Trp Tyr Ile Asp Glu Val Ala Glu Asp Pro 
    370                 375                 380                 


Ala Lys Ser Leu Thr Glu Ile Ser Thr Asp Phe Asp Arg Ser Ser Pro 
385                 390                 395                 400 


Pro Leu Gln Pro Pro Pro Val Asn Ser Leu Thr Thr Glu Asn Arg Phe 
                405                 410                 415     


His Ser Leu Pro Phe Ser Leu Thr Lys Met Pro Asn Thr Asn Gly Ser 
            420                 425                 430         


Ile Gly His Ser Pro Leu Ser Leu Ser Ala Gln Ser Val Met Glu Glu 
        435                 440                 445             


Leu Asn Thr Ala Pro Val Gln Glu Ser Pro Pro Leu Ala Met Pro Pro 
    450                 455                 460                 


Gly Asn Ser His Gly Leu Glu Val Gly Ser Leu Ala Glu Val Lys Glu 
465                 470                 475                 480 


Asn Pro Pro Phe Tyr Gly Val Ile Arg Trp Ile Gly Gln Pro Pro Gly 
                485                 490                 495     


Leu Asn Glu Val Leu Ala Gly Leu Glu Leu Glu Asp Glu Cys Ala Gly 
            500                 505                 510         


Cys Thr Asp Gly Thr Phe Arg Gly Thr Arg Tyr Phe Thr Cys Ala Leu 
        515                 520                 525             


Lys Lys Ala Leu Phe Val Lys Leu Lys Ser Cys Arg Pro Asp Ser Arg 
    530                 535                 540                 


Phe Ala Ser Leu Gln Pro Val Ser Asn Gln Ile Glu Arg Cys Asn Ser 
545                 550                 555                 560 


Leu Ala Phe Gly Gly Tyr Leu Ser Glu Val Val Glu Glu Asn Thr Pro 
                565                 570                 575     


Pro Lys Met Glu Lys Glu Gly Leu Glu Ile Met Ile Gly Lys Lys Lys 
            580                 585                 590         


Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp Ser Thr Leu Phe 
        595                 600                 605             


Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Thr Val Leu Leu Arg Pro 
    610                 615                 620                 


Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Thr Gln Glu Leu Leu 
625                 630                 635                 640 


Arg Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly Tyr Val Cys Ala 
                645                 650                 655     


Thr Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys Val Glu Ala Ala 
            660                 665                 670         


Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu Phe Leu Asn Ile 
        675                 680                 685             


Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu Lys Ile Arg Ser 
    690                 695                 700                 


Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln Ile Phe Met Glu 
705                 710                 715                 720 


Lys Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln Leu Leu Glu Trp 
                725                 730                 735     


Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala Pro Ser Cys Leu 
            740                 745                 750         


Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys Leu Phe Lys Lys 
        755                 760                 765             


Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu Leu Glu Asp Thr 
    770                 775                 780                 


Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met Tyr Glu Cys Arg 
785                 790                 795                 800 


Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys Ile Lys Gln Phe 
                805                 810                 815     


Cys Lys Thr Cys Asn Thr Gln Val His Leu His Pro Lys Arg Leu Asn 
            820                 825                 830         


His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu Pro Asp Trp Asp 
        835                 840                 845             


Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu Leu Phe Ala Val 
    850                 855                 860                 


Leu Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val Lys Tyr Gly Lys 
865                 870                 875                 880 


Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala Asp Arg Asp Gly 
                885                 890                 895     


Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro Cys Pro Glu Val 
            900                 905                 910         


Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His Ser Leu Asp Ser 
        915                 920                 925             


Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys Asp Ala Tyr Met 
    930                 935                 940                 


Cys Met Tyr Gln Ser Pro Thr Met Ser Leu Tyr Lys 
945                 950                 955     


<210> 69
<211> 823
<212> PRT
<213> Homo sapiens

<400> 69
Met Gly Lys Lys Arg Thr Lys Gly Lys Thr Val Pro Ile Asp Asp Ser 
1               5                   10                  15      


Ser Glu Thr Leu Glu Pro Val Cys Arg His Ile Arg Lys Gly Leu Glu 
            20                  25                  30          


Gln Gly Asn Leu Lys Lys Ala Leu Val Asn Val Glu Trp Asn Ile Cys 
        35                  40                  45              


Gln Asp Cys Lys Thr Asp Asn Lys Val Lys Asp Lys Ala Glu Glu Glu 
    50                  55                  60                  


Thr Glu Glu Lys Pro Ser Val Trp Leu Cys Leu Lys Cys Gly His Gln 
65                  70                  75                  80  


Gly Cys Gly Arg Asn Ser Gln Glu Gln His Ala Leu Lys His Tyr Leu 
                85                  90                  95      


Thr Pro Arg Ser Glu Pro His Cys Leu Val Leu Ser Leu Asp Asn Trp 
            100                 105                 110         


Ser Val Trp Cys Tyr Val Cys Asp Asn Glu Val Gln Tyr Cys Ser Ser 
        115                 120                 125             


Asn Gln Leu Gly Gln Val Val Asp Tyr Val Arg Lys Gln Ala Ser Ile 
    130                 135                 140                 


Thr Thr Pro Lys Pro Ala Glu Lys Asp Asn Gly Asn Ile Glu Leu Glu 
145                 150                 155                 160 


Asn Lys Lys Leu Glu Lys Glu Ser Lys Asn Glu Gln Glu Arg Glu Lys 
                165                 170                 175     


Lys Glu Asn Met Ala Lys Glu Asn Pro Pro Met Asn Ser Pro Cys Gln 
            180                 185                 190         


Ile Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn 
        195                 200                 205             


Ala Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu 
    210                 215                 220                 


Lys Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp 
225                 230                 235                 240 


Leu Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro 
                245                 250                 255     


Leu Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys 
            260                 265                 270         


Lys Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys 
        275                 280                 285             


Ala Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu 
    290                 295                 300                 


Arg Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser 
305                 310                 315                 320 


Lys Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu 
                325                 330                 335     


Glu Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro 
            340                 345                 350         


Ser Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met 
        355                 360                 365             


Cys Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp 
    370                 375                 380                 


Leu Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn 
385                 390                 395                 400 


Asp Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu 
                405                 410                 415     


Glu Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro 
            420                 425                 430         


Ser Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys 
        435                 440                 445             


Lys Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val 
    450                 455                 460                 


Leu His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu 
465                 470                 475                 480 


Tyr Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn 
                485                 490                 495     


His Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln 
            500                 505                 510         


Lys Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn 
        515                 520                 525             


Gln Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn 
    530                 535                 540                 


Asp Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala 
545                 550                 555                 560 


Tyr Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe 
                565                 570                 575     


Lys Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile 
            580                 585                 590         


Glu Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val 
        595                 600                 605             


Val Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu 
    610                 615                 620                 


Val Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe 
625                 630                 635                 640 


Thr Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val 
                645                 650                 655     


Cys Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu 
            660                 665                 670         


Arg Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu 
        675                 680                 685             


Ala Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly 
    690                 695                 700                 


Phe Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu 
705                 710                 715                 720 


Asp Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu 
                725                 730                 735     


Asn Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly 
            740                 745                 750         


Thr Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala 
        755                 760                 765             


Asn Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp 
    770                 775                 780                 


Phe Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His 
785                 790                 795                 800 


Val Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu 
                805                 810                 815     


Leu Phe Tyr Glu Arg Ile Leu 
            820             


<210> 70
<211> 1137
<212> PRT
<213> Homo sapiens

<400> 70
Met Lys Cys Val Phe Val Thr Val Gly Thr Thr Ser Phe Asp Asp Leu 
1               5                   10                  15      


Ile Ala Cys Val Ser Ala Pro Asp Ser Leu Gln Lys Ile Glu Ser Leu 
            20                  25                  30          


Gly Tyr Asn Arg Leu Ile Leu Gln Ile Gly Arg Gly Thr Val Val Pro 
        35                  40                  45              


Glu Pro Phe Ser Thr Glu Ser Phe Thr Leu Asp Val Tyr Arg Tyr Lys 
    50                  55                  60                  


Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu Val Ile Ser His 
65                  70                  75                  80  


Ala Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys Gly Lys Pro Leu 
                85                  90                  95      


Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His Gln Leu Glu Leu 
            100                 105                 110         


Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr Cys Thr Cys Arg 
        115                 120                 125             


Val Leu Thr Cys Pro Gly Gln Ala Lys Ser Ile Ala Ser Ala Pro Gly 
    130                 135                 140                 


Lys Cys Gln Asp Ser Ala Ala Leu Thr Ser Thr Ala Phe Ser Gly Leu 
145                 150                 155                 160 


Asp Phe Gly Leu Leu Ser Gly Tyr Leu His Lys Gln Ala Leu Val Thr 
                165                 170                 175     


Ala Thr His Pro Thr Cys Thr Leu Leu Phe Pro Ser Cys His Ala Phe 
            180                 185                 190         


Phe Pro Leu Pro Leu Thr Pro Thr Leu Tyr Lys Met His Lys Gly Trp 
        195                 200                 205             


Lys Asn Tyr Cys Ser Gln Lys Ser Leu Asn Glu Ala Ser Met Asp Glu 
    210                 215                 220                 


Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr Ala Lys Asp Ala 
225                 230                 235                 240 


Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe Cys Ser Gln Val 
                245                 250                 255     


His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr Met Arg Glu Asn 
            260                 265                 270         


Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe Glu Lys Tyr Leu 
        275                 280                 285             


Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln Leu Glu Ile Arg 
    290                 295                 300                 


Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu Tyr Arg Phe Pro 
305                 310                 315                 320 


Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr Glu Asp Lys Ile 
                325                 330                 335     


Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser Val Tyr Ser Lys 
            340                 345                 350         


Gln Phe Gln Ser Ser Ala Ala Val Cys Gln Ala Val Leu Tyr Glu Ile 
        355                 360                 365             


Leu Tyr Lys Asp Val Phe Val Val Asp Glu Glu Glu Leu Lys Thr Ala 
    370                 375                 380                 


Ile Lys Leu Phe Arg Ser Gly Ser Lys Lys Asn Arg Asn Asn Ala Val 
385                 390                 395                 400 


Thr Gly Ser Glu Asp Ala His Thr Asp Tyr Lys Ser Ser Asn Gln Asn 
                405                 410                 415     


Arg Met Glu Glu Trp Gly Ala Cys Tyr Asn Ala Glu Asn Ile Pro Glu 
            420                 425                 430         


Gly Tyr Asn Lys Gly Thr Glu Glu Thr Lys Ser Pro Glu Asn Pro Ser 
        435                 440                 445             


Lys Met Pro Phe Pro Tyr Lys Val Leu Lys Ala Leu Asp Pro Glu Ile 
    450                 455                 460                 


Tyr Arg Asn Val Glu Phe Asp Val Trp Leu Asp Ser Arg Lys Glu Leu 
465                 470                 475                 480 


Gln Lys Ser Asp Tyr Met Glu Tyr Ala Gly Arg Gln Tyr Tyr Leu Gly 
                485                 490                 495     


Asp Lys Cys Gln Val Cys Leu Glu Ser Glu Gly Arg Tyr Tyr Asn Ala 
            500                 505                 510         


His Ile Gln Glu Val Gly Asn Glu Asn Asn Ser Val Thr Val Phe Ile 
        515                 520                 525             


Glu Glu Leu Ala Glu Lys His Val Val Pro Leu Ala Asn Leu Lys Pro 
    530                 535                 540                 


Val Thr Gln Val Met Ser Val Pro Ala Trp Asn Ala Met Pro Ser Arg 
545                 550                 555                 560 


Lys Gly Arg Gly Tyr Gln Lys Met Pro Gly Gly Tyr Val Pro Glu Ile 
                565                 570                 575     


Val Ile Ser Glu Met Asp Ile Lys Gln Gln Lys Lys Met Phe Lys Lys 
            580                 585                 590         


Ile Arg Gly Lys Glu Val Tyr Met Thr Met Ala Tyr Gly Lys Gly Asp 
        595                 600                 605             


Pro Leu Leu Pro Pro Arg Leu Gln His Ser Met His Tyr Gly His Asp 
    610                 615                 620                 


Pro Pro Met His Tyr Ser Gln Thr Ala Gly Asn Val Met Ser Asn Glu 
625                 630                 635                 640 


His Phe His Pro Gln His Pro Ser Pro Arg Gln Gly Arg Gly Tyr Gly 
                645                 650                 655     


Met Pro Arg Asn Ser Ser Arg Phe Ile Asn Arg His Asn Met Pro Gly 
            660                 665                 670         


Pro Lys Val Asp Phe Tyr Pro Gly Pro Gly Lys Arg Cys Cys Gln Ser 
        675                 680                 685             


Tyr Asp Asn Phe Ser Tyr Arg Ser Arg Ser Phe Arg Arg Ser His Arg 
    690                 695                 700                 


Gln Met Ser Cys Val Asn Lys Glu Ser Gln Tyr Gly Phe Thr Pro Gly 
705                 710                 715                 720 


Asn Gly Gln Met Pro Arg Gly Leu Glu Glu Thr Ile Thr Phe Tyr Glu 
                725                 730                 735     


Val Glu Glu Gly Asp Glu Thr Ala Tyr Pro Thr Leu Pro Asn His Gly 
            740                 745                 750         


Gly Pro Ser Thr Met Val Pro Ala Thr Ser Gly Tyr Cys Val Gly Arg 
        755                 760                 765             


Arg Gly His Ser Ser Gly Lys Gln Thr Leu Asn Leu Glu Glu Gly Asn 
    770                 775                 780                 


Gly Gln Ser Glu Asn Gly Arg Tyr His Glu Glu Tyr Leu Tyr Arg Ala 
785                 790                 795                 800 


Glu Pro Asp Tyr Glu Thr Ser Gly Val Tyr Ser Thr Thr Ala Ser Thr 
                805                 810                 815     


Ala Asn Leu Ser Leu Gln Asp Arg Lys Ser Cys Ser Met Ser Pro Gln 
            820                 825                 830         


Asp Thr Val Thr Ser Tyr Asn Tyr Pro Gln Lys Met Met Gly Asn Ile 
        835                 840                 845             


Ala Ala Val Ala Ala Ser Cys Ala Asn Asn Val Pro Ala Pro Val Leu 
    850                 855                 860                 


Ser Asn Gly Ala Ala Ala Asn Gln Ala Ile Ser Thr Thr Ser Val Ser 
865                 870                 875                 880 


Ser Gln Asn Ala Ile Gln Pro Leu Phe Val Ser Pro Pro Thr His Gly 
                885                 890                 895     


Arg Pro Val Ile Ala Ser Pro Ser Tyr Pro Cys His Ser Ala Ile Pro 
            900                 905                 910         


His Ala Gly Ala Ser Leu Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
        915                 920                 925             


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro 
    930                 935                 940                 


Pro Ala Leu Asp Val Gly Glu Thr Ser Asn Leu Gln Pro Pro Pro Pro 
945                 950                 955                 960 


Leu Pro Pro Pro Pro Tyr Ser Cys Asp Pro Ser Gly Ser Asp Leu Pro 
                965                 970                 975     


Gln Asp Thr Lys Val Leu Gln Tyr Tyr Phe Asn Leu Gly Leu Gln Cys 
            980                 985                 990         


Tyr Tyr His Ser Tyr Trp His Ser  Met Val Tyr Val Pro  Gln Met Gln 
        995                 1000                 1005             


Gln Gln  Leu His Val Glu Asn  Tyr Pro Val Tyr Thr  Glu Pro Pro 
    1010                 1015                 1020             


Leu Val  Asp Gln Thr Val Pro  Gln Cys Tyr Ser Glu  Val Arg Arg 
    1025                 1030                 1035             


Glu Asp  Gly Ile Gln Ala Glu  Ala Ser Ala Asn Asp  Thr Phe Pro 
    1040                 1045                 1050             


Asn Ala  Asp Ser Ser Ser Val  Pro His Gly Ala Val  Tyr Tyr Pro 
    1055                 1060                 1065             


Val Met  Ser Asp Pro Tyr Gly  Gln Pro Pro Leu Pro  Gly Phe Asp 
    1070                 1075                 1080             


Ser Cys  Leu Pro Val Val Pro  Asp Tyr Ser Cys Val  Pro Pro Trp 
    1085                 1090                 1095             


His Pro  Val Gly Thr Ala Tyr  Gly Gly Ser Ser Gln  Ile His Gly 
    1100                 1105                 1110             


Ala Ile  Asn Pro Gly Pro Ile  Gly Cys Ile Ala Pro  Ser Pro Pro 
    1115                 1120                 1125             


Ala Ser  His Tyr Val Pro Gln  Gly Met 
    1130                 1135         


<210> 71
<211> 348
<212> PRT
<213> Homo sapiens

<400> 71
Met Phe Gly Pro Ala Lys Gly Arg His Phe Gly Val His Pro Ala Pro 
1               5                   10                  15      


Gly Phe Pro Gly Gly Val Ser Gln Gln Ala Ala Gly Thr Lys Ala Gly 
            20                  25                  30          


Pro Ala Gly Ala Trp Pro Val Gly Ser Arg Thr Asp Thr Met Trp Arg 
        35                  40                  45              


Leu Arg Cys Lys Ala Lys Asp Gly Thr His Val Leu Gln Gly Leu Ser 
    50                  55                  60                  


Ser Arg Thr Arg Val Arg Glu Leu Gln Gly Gln Ile Ala Ala Ile Thr 
65                  70                  75                  80  


Gly Ile Ala Pro Gly Gly Gln Arg Ile Leu Val Gly Tyr Pro Pro Glu 
                85                  90                  95      


Cys Leu Asp Leu Ser Asn Gly Asp Thr Ile Leu Glu Asp Leu Pro Ile 
            100                 105                 110         


Gln Ser Gly Asp Met Leu Ile Ile Glu Glu Asp Gln Thr Arg Pro Arg 
        115                 120                 125             


Ser Ser Pro Ala Phe Thr Lys Arg Gly Ala Ser Ser Tyr Val Arg Glu 
    130                 135                 140                 


Thr Leu Pro Val Leu Thr Arg Thr Val Val Pro Ala Asp Asn Ser Cys 
145                 150                 155                 160 


Leu Phe Thr Ser Val Tyr Tyr Val Val Glu Gly Gly Val Leu Asn Pro 
                165                 170                 175     


Ala Cys Ala Pro Glu Met Arg Arg Leu Ile Ala Gln Ile Val Ala Ser 
            180                 185                 190         


Asp Pro Asp Phe Tyr Ser Glu Ala Ile Leu Gly Lys Thr Asn Gln Glu 
        195                 200                 205             


Tyr Cys Asp Trp Ile Lys Arg Asp Asp Thr Trp Gly Gly Ala Ile Glu 
    210                 215                 220                 


Ile Ser Ile Leu Ser Lys Phe Tyr Gln Cys Glu Ile Cys Val Val Asp 
225                 230                 235                 240 


Thr Gln Thr Val Arg Ile Asp Arg Phe Gly Glu Asp Ala Gly Tyr Thr 
                245                 250                 255     


Lys Arg Val Leu Leu Ile Tyr Asp Gly Ile His Tyr Asp Pro Leu Gln 
            260                 265                 270         


Arg Asn Phe Pro Asp Pro Asp Thr Pro Pro Leu Thr Ile Phe Ser Ser 
        275                 280                 285             


Asn Asp Asp Ile Val Leu Val Gln Ala Leu Glu Leu Ala Asp Glu Ala 
    290                 295                 300                 


Arg Arg Arg Arg Gln Phe Thr Asp Val Asn Arg Phe Thr Leu Arg Cys 
305                 310                 315                 320 


Met Val Cys Gln Lys Gly Leu Thr Gly Gln Ala Glu Ala Arg Glu His 
                325                 330                 335     


Ala Lys Glu Thr Gly His Thr Asn Phe Gly Glu Val 
            340                 345             


<210> 72
<211> 481
<212> PRT
<213> Homo sapiens

<400> 72
Met Gln Leu Tyr Ser Ser Val Cys Thr His Tyr Pro Ala Gly Ala Pro 
1               5                   10                  15      


Gly Pro Thr Ala Ala Ala Pro Ala Pro Pro Ala Ala Ala Thr Pro Phe 
            20                  25                  30          


Lys Val Ser Leu Gln Pro Pro Gly Ala Ala Gly Ala Ala Pro Glu Pro 
        35                  40                  45              


Glu Thr Gly Glu Cys Gln Pro Ala Ala Ala Ala Glu His Arg Glu Ala 
    50                  55                  60                  


Ala Ala Val Pro Ala Ala Lys Met Pro Ala Phe Ser Ser Cys Phe Glu 
65                  70                  75                  80  


Val Val Ser Gly Ala Ala Ala Pro Ala Ser Ala Ala Ala Gly Pro Pro 
                85                  90                  95      


Gly Ala Ser Cys Lys Pro Pro Leu Pro Pro His Tyr Thr Ser Thr Ala 
            100                 105                 110         


Gln Ile Thr Val Arg Ala Leu Gly Ala Asp Arg Leu Leu Leu His Gly 
        115                 120                 125             


Pro Asp Pro Val Pro Gly Ala Ala Gly Ser Ala Ala Ala Pro Arg Gly 
    130                 135                 140                 


Arg Cys Leu Leu Leu Ala Pro Ala Pro Ala Ala Pro Val Pro Pro Arg 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Trp Leu Leu Glu Glu Leu Leu Arg Pro Asp Cys 
                165                 170                 175     


Pro Glu Pro Ala Gly Leu Asp Ala Thr Arg Glu Gly Pro Asp Arg Asn 
            180                 185                 190         


Phe Arg Leu Ser Glu His Arg Gln Ala Leu Ala Ala Ala Lys His Arg 
        195                 200                 205             


Gly Pro Ala Ala Thr Pro Gly Ser Pro Asp Pro Gly Pro Gly Pro Trp 
    210                 215                 220                 


Gly Glu Glu His Leu Ala Glu Arg Gly Pro Arg Gly Trp Glu Arg Gly 
225                 230                 235                 240 


Gly Asp Arg Cys Asp Ala Pro Gly Gly Asp Ala Ala Arg Arg Pro Asp 
                245                 250                 255     


Pro Glu Ala Glu Ala Pro Pro Ala Gly Ser Ile Glu Ala Ala Pro Ser 
            260                 265                 270         


Ser Ala Ala Glu Pro Val Ile Val Ser Arg Ser Asp Pro Arg Asp Glu 
        275                 280                 285             


Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln Asp Lys Tyr Leu 
    290                 295                 300                 


Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro Asp Gly Asn Cys 
305                 310                 315                 320 


Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp Gln Ser Leu His 
                325                 330                 335     


Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala Asp His Leu Asp 
            340                 345                 350         


His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu Phe Ile Ile Ala 
        355                 360                 365             


Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu Leu Leu Ala Met 
    370                 375                 380                 


Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr Gly Gly Arg Leu 
385                 390                 395                 400 


Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu Gly Pro Glu Asp 
                405                 410                 415     


Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser Asn Gly His Tyr 
            420                 425                 430         


Asp Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu Tyr Asp Asn Trp 
        435                 440                 445             


Cys Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu Glu Leu Ala Lys 
    450                 455                 460                 


Ser Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu Gln Asn Ala Cys 
465                 470                 475                 480 


Ser 
    


<210> 73
<211> 293
<212> PRT
<213> Homo sapiens

<400> 73
Met Glu Ala Val Leu Thr Glu Glu Leu Asp Glu Glu Glu Gln Leu Leu 
1               5                   10                  15      


Arg Arg His Arg Lys Glu Lys Lys Glu Leu Gln Ala Lys Ile Gln Gly 
            20                  25                  30          


Met Lys Asn Ala Val Pro Lys Asn Asp Lys Lys Arg Arg Lys Gln Leu 
        35                  40                  45              


Thr Glu Asp Val Ala Lys Leu Glu Lys Glu Met Glu Gln Lys His Arg 
    50                  55                  60                  


Glu Glu Leu Glu Gln Leu Lys Leu Thr Thr Lys Glu Asn Lys Ile Asp 
65                  70                  75                  80  


Ser Val Ala Val Asn Ile Ser Asn Leu Val Leu Glu Asn Gln Pro Pro 
                85                  90                  95      


Arg Ile Ser Lys Ala Gln Lys Arg Arg Glu Lys Lys Ala Ala Leu Glu 
            100                 105                 110         


Lys Glu Arg Glu Glu Arg Ile Ala Glu Ala Glu Ile Glu Asn Leu Thr 
        115                 120                 125             


Gly Ala Arg His Met Glu Ser Glu Lys Leu Ala Gln Ile Leu Ala Ala 
    130                 135                 140                 


Arg Gln Leu Glu Ile Lys Gln Ile Pro Ser Asp Gly His Cys Met Tyr 
145                 150                 155                 160 


Lys Ala Ile Glu Asp Gln Leu Lys Glu Lys Asp Cys Ala Leu Thr Val 
                165                 170                 175     


Val Ala Leu Arg Ser Gln Thr Ala Glu Tyr Met Gln Ser His Val Glu 
            180                 185                 190         


Asp Phe Leu Pro Phe Leu Thr Asn Pro Asn Thr Gly Asp Met Tyr Thr 
        195                 200                 205             


Pro Glu Glu Phe Gln Lys Tyr Cys Glu Asp Ile Val Asn Thr Ala Ala 
    210                 215                 220                 


Trp Gly Gly Gln Leu Glu Leu Arg Ala Leu Ser His Ile Leu Gln Thr 
225                 230                 235                 240 


Pro Ile Glu Ile Ile Gln Ala Asp Ser Pro Pro Ile Ile Val Gly Glu 
                245                 250                 255     


Glu Tyr Ser Lys Lys Pro Leu Ile Leu Val Tyr Met Arg His Ala Tyr 
            260                 265                 270         


Gly Leu Gly Glu His Tyr Asn Ser Val Thr Arg Leu Val Asn Ile Val 
        275                 280                 285             


Thr Glu Asn Cys Ser 
    290             


<210> 74
<211> 288
<212> PRT
<213> Homo sapiens

<400> 74
Met Asp Asp Pro Lys Ser Glu Gln Gln Arg Ile Leu Arg Arg His Gln 
1               5                   10                  15      


Arg Glu Arg Gln Glu Leu Gln Ala Gln Ile Arg Ser Leu Lys Asn Ser 
            20                  25                  30          


Val Pro Lys Thr Asp Lys Thr Lys Arg Lys Gln Leu Leu Gln Asp Val 
        35                  40                  45              


Ala Arg Met Glu Ala Glu Met Ala Gln Lys His Arg Gln Glu Leu Glu 
    50                  55                  60                  


Lys Phe Gln Asp Asp Ser Ser Ile Glu Ser Val Val Glu Asp Leu Ala 
65                  70                  75                  80  


Lys Met Asn Leu Glu Asn Arg Pro Pro Arg Ser Ser Lys Ala His Arg 
                85                  90                  95      


Lys Arg Glu Arg Met Glu Ser Glu Glu Arg Glu Arg Gln Glu Ser Ile 
            100                 105                 110         


Phe Gln Ala Glu Met Ser Glu His Leu Ala Gly Phe Lys Arg Glu Glu 
        115                 120                 125             


Glu Glu Lys Leu Ala Ala Ile Leu Gly Ala Arg Gly Leu Glu Met Lys 
    130                 135                 140                 


Ala Ile Pro Ala Asp Gly His Cys Met Tyr Arg Ala Ile Gln Asp Gln 
145                 150                 155                 160 


Leu Val Phe Ser Val Ser Val Glu Met Leu Arg Cys Arg Thr Ala Ser 
                165                 170                 175     


Tyr Met Lys Lys His Val Asp Glu Phe Leu Pro Phe Phe Ser Asn Pro 
            180                 185                 190         


Glu Thr Ser Asp Ser Phe Gly Tyr Asp Asp Phe Met Ile Tyr Cys Asp 
        195                 200                 205             


Asn Ile Val Arg Thr Thr Ala Trp Gly Gly Gln Leu Glu Leu Arg Ala 
    210                 215                 220                 


Leu Ser His Val Leu Lys Thr Pro Ile Glu Val Ile Gln Ala Asp Ser 
225                 230                 235                 240 


Pro Thr Leu Ile Ile Gly Glu Glu Tyr Val Lys Lys Pro Ile Ile Leu 
                245                 250                 255     


Val Tyr Leu Arg Tyr Ala Tyr Ser Leu Gly Glu His Tyr Asn Ser Val 
            260                 265                 270         


Thr Pro Leu Glu Ala Gly Ala Ala Gly Gly Val Leu Pro Arg Leu Leu 
        275                 280                 285             


<210> 75
<211> 271
<212> PRT
<213> Homo sapiens

<400> 75
Met Ala Ala Glu Glu Pro Gln Gln Gln Lys Gln Glu Pro Leu Gly Ser 
1               5                   10                  15      


Asp Ser Glu Gly Val Asn Cys Leu Ala Tyr Asp Glu Ala Ile Met Ala 
            20                  25                  30          


Gln Gln Asp Arg Ile Gln Gln Glu Ile Ala Val Gln Asn Pro Leu Val 
        35                  40                  45              


Ser Glu Arg Leu Glu Leu Ser Val Leu Tyr Lys Glu Tyr Ala Glu Asp 
    50                  55                  60                  


Asp Asn Ile Tyr Gln Gln Lys Ile Lys Asp Leu His Lys Lys Tyr Ser 
65                  70                  75                  80  


Tyr Ile Arg Lys Thr Arg Pro Asp Gly Asn Cys Phe Tyr Arg Ala Phe 
                85                  90                  95      


Gly Phe Ser His Leu Glu Ala Leu Leu Asp Asp Ser Lys Glu Leu Gln 
            100                 105                 110         


Arg Phe Lys Ala Val Ser Ala Lys Ser Lys Glu Asp Leu Val Ser Gln 
        115                 120                 125             


Gly Phe Thr Glu Phe Thr Ile Glu Asp Phe His Asn Thr Phe Met Asp 
    130                 135                 140                 


Leu Ile Glu Gln Val Glu Lys Gln Thr Ser Val Ala Asp Leu Leu Ala 
145                 150                 155                 160 


Ser Phe Asn Asp Gln Ser Thr Ser Asp Tyr Leu Val Val Tyr Leu Arg 
                165                 170                 175     


Leu Leu Thr Ser Gly Tyr Leu Gln Arg Glu Ser Lys Phe Phe Glu His 
            180                 185                 190         


Phe Ile Glu Gly Gly Arg Thr Val Lys Glu Phe Cys Gln Gln Glu Val 
        195                 200                 205             


Glu Pro Met Cys Lys Glu Ser Asp His Ile His Ile Ile Ala Leu Ala 
    210                 215                 220                 


Gln Ala Leu Ser Val Ser Ile Gln Val Glu Tyr Met Asp Arg Gly Glu 
225                 230                 235                 240 


Gly Gly Thr Thr Asn Pro His Ile Phe Pro Glu Gly Ser Glu Pro Lys 
                245                 250                 255     


Val Tyr Leu Leu Tyr Arg Pro Gly His Tyr Asp Ile Leu Tyr Lys 
            260                 265                 270     


<210> 76
<211> 926
<212> PRT
<213> Homo sapiens

<400> 76
Met Val Ser Ser Val Leu Pro Asn Pro Thr Ser Ala Glu Cys Trp Ala 
1               5                   10                  15      


Ala Leu Leu His Asp Pro Met Thr Leu Asp Met Asp Ala Val Leu Ser 
            20                  25                  30          


Asp Phe Val Arg Ser Thr Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu 
        35                  40                  45              


Leu Glu Gly Lys Asn Trp Asp Leu Thr Ala Ala Leu Ser Asp Tyr Glu 
    50                  55                  60                  


Gln Leu Arg Gln Val His Thr Ala Asn Leu Pro His Val Phe Asn Glu 
65                  70                  75                  80  


Gly Arg Gly Pro Lys Gln Pro Glu Arg Glu Pro Gln Pro Gly His Lys 
                85                  90                  95      


Val Glu Arg Pro Cys Leu Gln Arg Gln Asp Asp Ile Ala Gln Glu Lys 
            100                 105                 110         


Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ala Ile Val Ser Leu 
        115                 120                 125             


Ala Arg Ser His Val Ala Ser Glu Cys Asn Asn Glu Gln Phe Pro Leu 
    130                 135                 140                 


Glu Met Pro Ile Tyr Thr Phe Gln Leu Pro Asp Leu Ser Val Tyr Ser 
145                 150                 155                 160 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ala Thr 
                165                 170                 175     


Met Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Ser Thr Val 
            180                 185                 190         


Cys Thr Ser Cys Lys Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
        195                 200                 205             


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
    210                 215                 220                 


Arg Asp Leu Val Leu Arg Lys Ala Leu Tyr Thr Met Met Arg Thr Gly 
225                 230                 235                 240 


Ala Glu Arg Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
                245                 250                 255     


Gln Asn Lys Glu Glu Glu Trp Glu Arg Glu Trp Thr Glu Leu Leu Lys 
            260                 265                 270         


Leu Ala Ser Ser Glu Pro Arg Thr His Phe Ser Lys Asn Gly Gly Thr 
        275                 280                 285             


Gly Gly Gly Val Asp Asn Ser Glu Asp Pro Val Tyr Glu Ser Leu Glu 
    290                 295                 300                 


Glu Phe His Val Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Val 
305                 310                 315                 320 


Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala 
                325                 330                 335     


Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val Pro Pro Asn 
            340                 345                 350         


Arg Cys His Cys Ser Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe 
        355                 360                 365             


Ser Ala Leu Val Ser Met Glu Gln Arg Asp Gln Gln Arg Glu Gln Ala 
    370                 375                 380                 


Val Ile Pro Leu Thr Asp Ser Glu His Lys Leu Leu Pro Leu His Phe 
385                 390                 395                 400 


Ala Val Asp Pro Gly Lys Asp Trp Glu Trp Gly Lys Asp Asp Asn Asp 
                405                 410                 415     


Asn Ala Arg Leu Ala His Leu Ile Leu Ser Leu Glu Ala Lys Leu Asn 
            420                 425                 430         


Leu Leu His Ser Tyr Met Asn Val Thr Trp Ile Arg Ile Pro Ser Glu 
        435                 440                 445             


Thr Arg Ala Pro Leu Ala Gln Pro Glu Ser Pro Thr Ala Ser Ala Gly 
    450                 455                 460                 


Glu Asp Val Gln Ser Leu Ala Asp Ser Leu Asp Ser Asp Arg Asp Ser 
465                 470                 475                 480 


Val Cys Ser Asn Ser Asn Ser Asn Asn Gly Lys Asn Gly Lys Asp Lys 
                485                 490                 495     


Glu Lys Glu Lys Gln Arg Lys Glu Lys Asp Lys Thr Arg Ala Asp Ser 
            500                 505                 510         


Val Ala Asn Lys Leu Gly Ser Phe Ser Lys Thr Leu Gly Ile Lys Leu 
        515                 520                 525             


Lys Lys Asn Met Gly Gly Leu Gly Gly Leu Val His Gly Lys Met Gly 
    530                 535                 540                 


Arg Ala Asn Ser Ala Asn Gly Lys Asn Gly Asp Ser Ala Glu Arg Gly 
545                 550                 555                 560 


Lys Glu Lys Lys Ala Lys Ser Arg Lys Gly Ser Lys Glu Glu Ser Gly 
                565                 570                 575     


Ala Ser Ala Ser Thr Ser Pro Ser Glu Lys Thr Thr Pro Ser Pro Thr 
            580                 585                 590         


Asp Lys Ala Ala Gly Ala Ser Pro Ala Glu Lys Gly Gly Gly Pro Arg 
        595                 600                 605             


Gly Asp Ala Trp Lys Tyr Ser Thr Asp Val Lys Leu Ser Leu Asn Ile 
    610                 615                 620                 


Leu Arg Ala Ala Met Gln Gly Glu Arg Lys Phe Ile Phe Ala Gly Leu 
625                 630                 635                 640 


Leu Leu Thr Ser His Arg His Gln Phe His Glu Glu Met Ile Gly Tyr 
                645                 650                 655     


Tyr Leu Thr Ser Ala Gln Glu Arg Phe Ser Ala Glu Gln Glu Gln Arg 
            660                 665                 670         


Arg Arg Asp Ala Ala Thr Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala 
        675                 680                 685             


Ala Thr Ala Lys Arg Pro Pro Arg Arg Pro Glu Thr Glu Gly Val Pro 
    690                 695                 700                 


Val Pro Glu Arg Ala Ser Pro Gly Pro Pro Thr Gln Leu Val Leu Lys 
705                 710                 715                 720 


Leu Lys Glu Arg Pro Ser Pro Gly Pro Ala Ala Gly Arg Ala Ala Arg 
                725                 730                 735     


Ala Ala Ala Gly Gly Thr Ala Ser Pro Gly Gly Gly Ala Arg Arg Ala 
            740                 745                 750         


Ser Ala Ser Gly Pro Val Pro Gly Arg Ser Pro Pro Ala Pro Ala Arg 
        755                 760                 765             


Gln Ser Val Ile His Val Gln Ala Ser Gly Ala Arg Asp Glu Ala Cys 
    770                 775                 780                 


Ala Pro Ala Val Gly Ala Leu Arg Pro Cys Ala Thr Tyr Pro Gln Gln 
785                 790                 795                 800 


Asn Arg Ser Leu Ser Ser Gln Ser Tyr Ser Pro Ala Arg Ala Ala Ala 
                805                 810                 815     


Leu Arg Thr Val Asn Thr Val Glu Ser Leu Ala Arg Ala Val Pro Gly 
            820                 825                 830         


Ala Leu Pro Gly Ala Ala Gly Thr Ala Gly Ala Ala Glu His Lys Ser 
        835                 840                 845             


Gln Thr Tyr Thr Asn Gly Phe Gly Ala Leu Arg Asp Gly Leu Glu Phe 
    850                 855                 860                 


Ala Asp Ala Asp Ala Pro Thr Ala Arg Ser Asn Gly Glu Cys Gly Arg 
865                 870                 875                 880 


Gly Gly Pro Gly Pro Val Gln Arg Arg Cys Gln Arg Glu Asn Cys Ala 
                885                 890                 895     


Phe Tyr Gly Arg Ala Glu Thr Glu His Tyr Cys Ser Tyr Cys Tyr Arg 
            900                 905                 910         


Glu Glu Leu Arg Arg Arg Arg Glu Ala Arg Gly Ala Arg Pro 
        915                 920                 925     


<210> 77
<211> 1113
<212> PRT
<213> Homo sapiens

<400> 77
Met Glu Ala Ala Val Gly Val Pro Asp Gly Gly Asp Gln Gly Gly Ala 
1               5                   10                  15      


Gly Pro Arg Glu Asp Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            20                  25                  30          


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        35                  40                  45              


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    50                  55                  60                  


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
65                  70                  75                  80  


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                85                  90                  95      


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            100                 105                 110         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        115                 120                 125             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    130                 135                 140                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser 
145                 150                 155                 160 


Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val 
                165                 170                 175     


Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu 
            180                 185                 190         


Val Ala Asp Glu Asp Asn Ser Glu Ile Ser Asp Ser Glu Asp Asp Ser 
        195                 200                 205             


Cys Lys Ser Lys Thr Ala Ala Ala Ala Ala Asp Val Asn Gly Phe Lys 
    210                 215                 220                 


Pro Leu Ser Gly Asn Glu Gln Leu Lys Asn Asn Gly Asn Ser Thr Ser 
225                 230                 235                 240 


Leu Pro Leu Ser Arg Lys Val Leu Lys Ser Leu Asn Pro Ala Val Tyr 
                245                 250                 255     


Arg Asn Val Glu Tyr Glu Ile Trp Leu Lys Ser Lys Gln Ala Gln Gln 
            260                 265                 270         


Lys Arg Asp Tyr Ser Ile Ala Ala Gly Leu Gln Tyr Glu Val Gly Asp 
        275                 280                 285             


Lys Cys Gln Val Arg Leu Asp His Asn Gly Lys Phe Leu Asn Ala Asp 
    290                 295                 300                 


Val Gln Gly Ile His Ser Glu Asn Gly Pro Val Leu Val Glu Glu Leu 
305                 310                 315                 320 


Gly Lys Lys His Thr Ser Lys Asn Leu Lys Ala Pro Pro Pro Glu Ser 
                325                 330                 335     


Trp Asn Thr Val Ser Gly Lys Lys Met Lys Lys Pro Ser Thr Ser Gly 
            340                 345                 350         


Gln Asn Phe His Ser Asp Val Asp Tyr Arg Gly Pro Lys Asn Pro Ser 
        355                 360                 365             


Lys Pro Ile Lys Ala Pro Ser Ala Leu Pro Pro Arg Leu Gln His Pro 
    370                 375                 380                 


Ser Gly Val Arg Gln His Ala Phe Ser Ser His Ser Ser Gly Ser Gln 
385                 390                 395                 400 


Ser Gln Lys Phe Ser Ser Glu His Lys Asn Leu Ser Arg Thr Pro Ser 
                405                 410                 415     


Gln Ile Ile Arg Lys Pro Asp Arg Glu Arg Val Glu Asp Phe Asp His 
            420                 425                 430         


Thr Ser Arg Glu Ser Asn Tyr Phe Gly Leu Ser Pro Glu Glu Arg Arg 
        435                 440                 445             


Glu Lys Gln Ala Ile Glu Glu Ser Arg Leu Leu Tyr Glu Ile Gln Asn 
    450                 455                 460                 


Arg Asp Glu Gln Ala Phe Pro Ala Leu Ser Ser Ser Ser Val Asn Gln 
465                 470                 475                 480 


Ser Ala Ser Gln Ser Ser Asn Pro Cys Val Gln Arg Lys Ser Ser His 
                485                 490                 495     


Val Gly Asp Arg Lys Gly Ser Arg Arg Arg Met Asp Thr Glu Glu Arg 
            500                 505                 510         


Lys Asp Lys Asp Ser Ile His Gly His Ser Gln Leu Asp Lys Arg Pro 
        515                 520                 525             


Glu Pro Ser Thr Leu Glu Asn Ile Thr Asp Asp Lys Tyr Ala Thr Val 
    530                 535                 540                 


Ser Ser Pro Ser Lys Ser Lys Lys Leu Glu Cys Pro Ser Pro Ala Glu 
545                 550                 555                 560 


Gln Lys Pro Ala Glu His Val Ser Leu Ser Asn Pro Ala Pro Leu Leu 
                565                 570                 575     


Val Ser Pro Glu Val His Leu Thr Pro Ala Val Pro Ser Leu Pro Ala 
            580                 585                 590         


Thr Val Pro Ala Trp Pro Ser Glu Pro Thr Thr Phe Gly Pro Thr Gly 
        595                 600                 605             


Val Pro Ala Pro Ile Pro Val Leu Ser Val Thr Gln Thr Leu Thr Thr 
    610                 615                 620                 


Gly Pro Asp Ser Ala Val Ser Gln Ala His Leu Thr Pro Ser Pro Val 
625                 630                 635                 640 


Pro Val Ser Ile Gln Ala Val Asn Gln Pro Leu Met Pro Leu Pro Gln 
                645                 650                 655     


Thr Leu Ser Leu Tyr Gln Asp Pro Leu Tyr Pro Gly Phe Pro Cys Asn 
            660                 665                 670         


Glu Lys Gly Asp Arg Ala Ile Val Pro Pro Tyr Ser Leu Cys Gln Thr 
        675                 680                 685             


Gly Glu Asp Leu Pro Lys Asp Lys Asn Ile Leu Arg Phe Phe Phe Asn 
    690                 695                 700                 


Leu Gly Val Lys Ala Tyr Ser Cys Pro Met Trp Ala Pro His Ser Tyr 
705                 710                 715                 720 


Leu Tyr Pro Leu His Gln Ala Tyr Leu Ala Ala Cys Arg Met Tyr Pro 
                725                 730                 735     


Lys Val Pro Val Pro Val Tyr Pro His Asn Pro Trp Phe Gln Glu Ala 
            740                 745                 750         


Pro Ala Ala Gln Asn Glu Ser Asp Cys Thr Cys Thr Asp Ala His Phe 
        755                 760                 765             


Pro Met Gln Thr Glu Ala Ser Val Asn Gly Gln Met Pro Gln Pro Glu 
    770                 775                 780                 


Ile Gly Pro Pro Thr Phe Ser Ser Pro Leu Val Ile Pro Pro Ser Gln 
785                 790                 795                 800 


Val Ser Glu Ser His Gly Gln Leu Ser Tyr Gln Ala Asp Leu Glu Ser 
                805                 810                 815     


Glu Thr Pro Gly Gln Leu Leu His Ala Asp Tyr Glu Glu Ser Leu Ser 
            820                 825                 830         


Gly Lys Asn Met Phe Pro Gln Ser Phe Gly Pro Asn Pro Phe Leu Gly 
        835                 840                 845             


Pro Val Pro Ile Ala Pro Pro Phe Phe Pro His Val Trp Tyr Gly Tyr 
    850                 855                 860                 


Pro Phe Gln Gly Phe Ile Glu Asn Pro Val Met Arg Gln Asn Ile Val 
865                 870                 875                 880 


Leu Pro Ser Asp Glu Lys Gly Glu Leu Asp Leu Ser Leu Glu Asn Leu 
                885                 890                 895     


Asp Leu Ser Lys Asp Cys Gly Ser Val Ser Thr Val Asp Glu Phe Pro 
            900                 905                 910         


Glu Ala Arg Gly Glu His Val His Ser Leu Pro Glu Ala Ser Val Ser 
        915                 920                 925             


Ser Lys Pro Asp Glu Gly Arg Thr Glu Gln Ser Ser Gln Thr Arg Lys 
    930                 935                 940                 


Ala Asp Thr Ala Leu Ala Ser Ile Pro Pro Val Ala Glu Gly Lys Ala 
945                 950                 955                 960 


His Pro Pro Thr Gln Ile Leu Asn Arg Glu Arg Glu Thr Val Pro Val 
                965                 970                 975     


Glu Leu Glu Pro Lys Arg Thr Ile Gln Ser Leu Lys Glu Lys Thr Glu 
            980                 985                 990         


Lys Val Lys Asp Pro Lys Thr Ala  Ala Asp Val Val Ser  Pro Gly Ala 
        995                 1000                 1005             


Asn Ser  Val Asp Ser Arg Val  Gln Arg Pro Lys Glu  Glu Ser Ser 
    1010                 1015                 1020             


Glu Asp  Glu Asn Glu Val Ser  Asn Ile Leu Arg Ser  Gly Arg Ser 
    1025                 1030                 1035             


Lys Gln  Phe Tyr Asn Gln Thr  Tyr Gly Ser Arg Lys  Tyr Lys Ser 
    1040                 1045                 1050             


Asp Trp  Gly Tyr Ser Gly Arg  Gly Gly Tyr Gln His  Val Arg Ser 
    1055                 1060                 1065             


Glu Glu  Ser Trp Lys Gly Gln  Pro Ser Arg Ser Arg  Asp Glu Gly 
    1070                 1075                 1080             


Tyr Gln  Tyr His Arg Asn Val  Arg Gly Arg Pro Phe  Arg Gly Asp 
    1085                 1090                 1095             


Arg Arg  Arg Ser Gly Met Gly  Asp Gly His Arg Gly  Gln His Thr 
    1100                 1105                 1110             


<210> 78
<211> 234
<212> PRT
<213> Homo sapiens

<400> 78
Met Ser Glu Thr Ser Phe Asn Leu Ile Ser Glu Lys Cys Asp Ile Leu 
1               5                   10                  15      


Ser Ile Leu Arg Asp His Pro Glu Asn Arg Ile Tyr Arg Arg Lys Ile 
            20                  25                  30          


Glu Glu Leu Ser Lys Arg Phe Thr Ala Ile Arg Lys Thr Lys Gly Asp 
        35                  40                  45              


Gly Asn Cys Phe Tyr Arg Ala Leu Gly Tyr Ser Tyr Leu Glu Ser Leu 
    50                  55                  60                  


Leu Gly Lys Ser Arg Glu Ile Phe Lys Phe Lys Glu Arg Val Leu Gln 
65                  70                  75                  80  


Thr Pro Asn Asp Leu Leu Ala Ala Gly Phe Glu Glu His Lys Phe Arg 
                85                  90                  95      


Asn Phe Phe Asn Ala Phe Tyr Ser Val Val Glu Leu Val Glu Lys Asp 
            100                 105                 110         


Gly Ser Val Ser Ser Leu Leu Lys Val Phe Asn Asp Gln Ser Ala Ser 
        115                 120                 125             


Asp His Ile Val Gln Phe Leu Arg Leu Leu Thr Ser Ala Phe Ile Arg 
    130                 135                 140                 


Asn Arg Ala Asp Phe Phe Arg His Phe Ile Asp Glu Glu Met Asp Ile 
145                 150                 155                 160 


Lys Asp Phe Cys Thr His Glu Val Glu Pro Met Ala Thr Glu Cys Asp 
                165                 170                 175     


His Ile Gln Ile Thr Ala Leu Ser Gln Ala Leu Ser Ile Ala Leu Gln 
            180                 185                 190         


Val Glu Tyr Val Asp Glu Met Asp Thr Ala Leu Asn His His Val Phe 
        195                 200                 205             


Pro Glu Ala Ala Thr Pro Ser Val Tyr Leu Leu Tyr Lys Thr Ser His 
    210                 215                 220                 


Tyr Asn Ile Leu Tyr Ala Ala Asp Lys His 
225                 230                 


<210> 79
<211> 398
<212> PRT
<213> Homo sapiens

<400> 79
Met Ser Arg Lys Gln Ala Ala Lys Ser Arg Pro Gly Ser Gly Ser Arg 
1               5                   10                  15      


Lys Ala Glu Ala Glu Arg Lys Arg Asp Glu Arg Ala Ala Arg Arg Ala 
            20                  25                  30          


Leu Ala Lys Glu Arg Arg Asn Arg Pro Glu Ser Gly Gly Gly Gly Gly 
        35                  40                  45              


Cys Glu Glu Glu Phe Val Ser Phe Ala Asn Gln Leu Gln Ala Leu Gly 
    50                  55                  60                  


Leu Lys Leu Arg Glu Val Pro Gly Asp Gly Asn Cys Leu Phe Arg Ala 
65                  70                  75                  80  


Leu Gly Asp Gln Leu Glu Gly His Ser Arg Asn His Leu Lys His Arg 
                85                  90                  95      


Gln Glu Thr Val Asp Tyr Met Ile Lys Gln Arg Glu Asp Phe Glu Pro 
            100                 105                 110         


Phe Val Glu Asp Asp Ile Pro Phe Glu Lys His Val Ala Ser Leu Ala 
        115                 120                 125             


Lys Pro Gly Thr Phe Ala Gly Asn Asp Ala Ile Val Ala Phe Ala Arg 
    130                 135                 140                 


Asn His Gln Leu Asn Val Val Ile His Gln Leu Asn Ala Pro Leu Trp 
145                 150                 155                 160 


Gln Ile Arg Gly Thr Glu Lys Ser Ser Val Arg Glu Leu His Ile Ala 
                165                 170                 175     


Tyr Arg Tyr Gly Glu His Tyr Asp Ser Val Arg Arg Ile Asn Asp Asn 
            180                 185                 190         


Ser Glu Ala Pro Ala His Leu Gln Thr Asp Phe Gln Met Leu His Gln 
        195                 200                 205             


Asp Glu Ser Asn Lys Arg Glu Lys Ile Lys Thr Lys Gly Met Asp Ser 
    210                 215                 220                 


Glu Asp Asp Leu Arg Asp Glu Val Glu Asp Ala Val Gln Lys Val Cys 
225                 230                 235                 240 


Asn Ala Thr Gly Cys Ser Asp Phe Asn Leu Ile Val Gln Asn Leu Glu 
                245                 250                 255     


Ala Glu Asn Tyr Asn Ile Glu Ser Ala Ile Ile Ala Val Leu Arg Met 
            260                 265                 270         


Asn Gln Gly Lys Arg Asn Asn Ala Glu Glu Asn Leu Glu Pro Ser Gly 
        275                 280                 285             


Arg Val Leu Lys Gln Cys Gly Pro Leu Trp Glu Glu Gly Gly Ser Gly 
    290                 295                 300                 


Ala Arg Ile Phe Gly Asn Gln Gly Leu Asn Glu Gly Arg Thr Glu Asn 
305                 310                 315                 320 


Asn Lys Ala Gln Ala Ser Pro Ser Glu Glu Asn Lys Ala Asn Lys Asn 
                325                 330                 335     


Gln Leu Ala Lys Val Thr Asn Lys Gln Arg Arg Glu Gln Gln Trp Met 
            340                 345                 350         


Glu Lys Lys Lys Arg Gln Glu Glu Arg His Arg His Lys Ala Leu Glu 
        355                 360                 365             


Ser Arg Gly Ser His Arg Asp Asn Asn Arg Ser Glu Ala Glu Ala Asn 
    370                 375                 380                 


Thr Gln Val Thr Leu Val Lys Thr Phe Ala Ala Leu Asn Ile 
385                 390                 395             


<210> 80
<211> 843
<212> PRT
<213> Homo sapiens

<400> 80
Met Thr Leu Asp Met Asp Ala Val Leu Ser Asp Phe Val Arg Ser Thr 
1               5                   10                  15      


Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu Leu Glu Gly Lys Asn Trp 
            20                  25                  30          


Asp Val Asn Ala Ala Leu Ser Asp Phe Glu Gln Leu Arg Gln Val His 
        35                  40                  45              


Ala Gly Asn Leu Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
    50                  55                  60                  


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
65                  70                  75                  80  


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
                85                  90                  95      


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
            100                 105                 110         


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
        115                 120                 125             


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
    130                 135                 140                 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
145                 150                 155                 160 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
                165                 170                 175     


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
            180                 185                 190         


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
        195                 200                 205             


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
    210                 215                 220                 


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
225                 230                 235                 240 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
                245                 250                 255     


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
            260                 265                 270         


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
        275                 280                 285             


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
    290                 295                 300                 


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
305                 310                 315                 320 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
                325                 330                 335     


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
            340                 345                 350         


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys 
        355                 360                 365             


Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr 
    370                 375                 380                 


Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu 
385                 390                 395                 400 


Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu 
                405                 410                 415     


Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys 
            420                 425                 430         


Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln Pro Glu 
        435                 440                 445             


Ser Pro Thr Ala Ser Ala Gly Asp Glu Pro Arg Ser Thr Pro Glu Ser 
    450                 455                 460                 


Gly Asp Ser Asp Lys Glu Ser Val Gly Ser Ser Ser Thr Ser Asn Glu 
465                 470                 475                 480 


Gly Gly Arg Arg Lys Glu Lys Ser Lys Arg Asp Arg Glu Lys Asp Lys 
                485                 490                 495     


Lys Arg Ala Asp Ser Val Ala Asn Lys Leu Gly Ser Phe Gly Lys Thr 
            500                 505                 510         


Leu Gly Ser Lys Leu Lys Lys Asn Met Gly Gly Leu Met His Ser Lys 
        515                 520                 525             


Gly Ser Lys Pro Gly Gly Val Gly Thr Gly Leu Gly Gly Ser Ser Gly 
    530                 535                 540                 


Thr Glu Thr Leu Glu Lys Lys Lys Lys Asn Ser Leu Lys Ser Trp Lys 
545                 550                 555                 560 


Gly Gly Lys Glu Glu Ala Ala Gly Asp Gly Pro Val Ser Glu Lys Pro 
                565                 570                 575     


Pro Ala Glu Ser Val Gly Asn Gly Gly Ser Lys Tyr Ser Gln Glu Val 
            580                 585                 590         


Met Gln Ser Leu Ser Ile Leu Arg Thr Ala Met Gln Gly Glu Gly Lys 
        595                 600                 605             


Phe Ile Phe Val Gly Thr Leu Lys Met Gly His Arg His Gln Tyr Gln 
    610                 615                 620                 


Glu Glu Met Ile Gln Arg Tyr Leu Ser Asp Ala Glu Glu Arg Phe Leu 
625                 630                 635                 640 


Ala Glu Gln Lys Gln Lys Glu Ala Glu Arg Lys Ile Met Asn Gly Gly 
                645                 650                 655     


Ile Gly Gly Gly Pro Pro Pro Ala Lys Lys Pro Glu Pro Asp Ala Arg 
            660                 665                 670         


Glu Glu Gln Pro Thr Gly Pro Pro Ala Glu Ser Arg Ala Met Ala Phe 
        675                 680                 685             


Ser Thr Gly Tyr Pro Gly Asp Phe Thr Ile Pro Arg Pro Ser Gly Gly 
    690                 695                 700                 


Gly Val His Cys Gln Glu Pro Arg Arg Gln Leu Ala Gly Gly Pro Cys 
705                 710                 715                 720 


Val Gly Gly Leu Pro Pro Tyr Ala Thr Phe Pro Arg Gln Cys Pro Pro 
                725                 730                 735     


Gly Arg Pro Tyr Pro His Gln Asp Ser Ile Pro Ser Leu Glu Pro Gly 
            740                 745                 750         


Ser His Ser Lys Asp Gly Leu His Arg Gly Ala Leu Leu Pro Pro Pro 
        755                 760                 765             


Tyr Arg Val Ala Asp Ser Tyr Ser Asn Gly Tyr Arg Glu Pro Pro Glu 
    770                 775                 780                 


Pro Asp Gly Trp Ala Gly Gly Leu Arg Gly Leu Pro Pro Thr Gln Thr 
785                 790                 795                 800 


Lys Cys Lys Gln Pro Asn Cys Ser Phe Tyr Gly His Pro Glu Thr Asn 
                805                 810                 815     


Asn Phe Cys Ser Cys Cys Tyr Arg Glu Glu Leu Arg Arg Arg Glu Arg 
            820                 825                 830         


Glu Pro Asp Gly Glu Leu Leu Val His Arg Phe 
        835                 840             


<210> 81
<211> 571
<212> PRT
<213> Homo sapiens

<400> 81
Met Thr Ile Leu Pro Lys Lys Lys Pro Pro Pro Pro Asp Ala Asp Pro 
1               5                   10                  15      


Ala Asn Glu Pro Pro Pro Pro Gly Pro Met Pro Pro Ala Pro Arg Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Val Gly Gly Gly Gly Thr Gly Val Gly Gly Gly 
        35                  40                  45              


Asp Arg Asp Arg Asp Ser Gly Val Val Gly Ala Arg Pro Arg Ala Ser 
    50                  55                  60                  


Pro Pro Pro Gln Gly Pro Leu Pro Gly Pro Pro Gly Ala Leu His Arg 
65                  70                  75                  80  


Trp Ala Leu Ala Val Pro Pro Gly Ala Val Ala Gly Pro Arg Pro Gln 
                85                  90                  95      


Gln Ala Ser Pro Pro Pro Cys Gly Gly Pro Gly Gly Pro Gly Gly Gly 
            100                 105                 110         


Pro Gly Asp Ala Leu Gly Ala Ala Ala Ala Gly Val Gly Ala Ala Gly 
        115                 120                 125             


Val Val Val Gly Val Gly Gly Ala Val Gly Val Gly Gly Cys Cys Ser 
    130                 135                 140                 


Gly Pro Gly His Ser Lys Arg Arg Arg Gln Ala Pro Gly Val Gly Ala 
145                 150                 155                 160 


Val Gly Gly Gly Ser Pro Glu Arg Glu Glu Val Gly Ala Gly Tyr Asn 
                165                 170                 175     


Ser Glu Asp Glu Tyr Glu Ala Ala Ala Ala Arg Ile Glu Ala Met Asp 
            180                 185                 190         


Pro Ala Thr Val Glu Gln Gln Glu His Trp Phe Glu Lys Ala Leu Arg 
        195                 200                 205             


Asp Lys Lys Gly Phe Ile Ile Lys Gln Met Lys Glu Asp Gly Ala Cys 
    210                 215                 220                 


Leu Phe Arg Ala Val Ala Asp Gln Val Tyr Gly Asp Gln Asp Met His 
225                 230                 235                 240 


Glu Val Val Arg Lys His Cys Met Asp Tyr Leu Met Lys Asn Ala Asp 
                245                 250                 255     


Tyr Phe Ser Asn Tyr Val Thr Glu Asp Phe Thr Thr Tyr Ile Asn Arg 
            260                 265                 270         


Lys Arg Lys Asn Asn Cys His Gly Asn His Ile Glu Met Gln Ala Met 
        275                 280                 285             


Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr Gln Tyr Ser Thr Gly 
    290                 295                 300                 


Thr Ser Ala Val Glu Pro Ile Asn Thr Phe His Gly Ile His Gln Asn 
305                 310                 315                 320 


Glu Asp Glu Pro Ile Arg Val Ser Tyr His Arg Asn Ile His Tyr Asn 
                325                 330                 335     


Ser Val Val Asn Pro Asn Lys Ala Thr Ile Gly Val Gly Leu Gly Leu 
            340                 345                 350         


Pro Ser Phe Lys Pro Gly Phe Ala Glu Gln Ser Leu Met Lys Asn Ala 
        355                 360                 365             


Ile Lys Thr Ser Glu Glu Ser Trp Ile Glu Gln Gln Met Leu Glu Asp 
    370                 375                 380                 


Lys Lys Arg Ala Thr Asp Trp Glu Ala Thr Asn Glu Ala Ile Glu Glu 
385                 390                 395                 400 


Gln Val Ala Arg Glu Ser Tyr Leu Gln Trp Leu Arg Asp Gln Glu Lys 
                405                 410                 415     


Gln Ala Arg Gln Val Arg Gly Pro Ser Gln Pro Arg Lys Ala Ser Ala 
            420                 425                 430         


Thr Cys Ser Ser Ala Thr Ala Ala Ala Ser Ser Gly Leu Glu Glu Trp 
        435                 440                 445             


Thr Ser Arg Ser Pro Arg Gln Arg Ser Ser Ala Ser Ser Pro Glu His 
    450                 455                 460                 


Pro Glu Leu His Ala Glu Leu Gly Met Lys Pro Pro Ser Pro Gly Thr 
465                 470                 475                 480 


Val Leu Ala Leu Ala Lys Pro Pro Ser Pro Cys Ala Pro Gly Thr Ser 
                485                 490                 495     


Ser Gln Phe Ser Ala Gly Ala Asp Arg Ala Thr Ser Pro Leu Val Ser 
            500                 505                 510         


Leu Tyr Pro Ala Leu Glu Cys Arg Ala Leu Ile Gln Gln Met Ser Pro 
        515                 520                 525             


Ser Ala Phe Gly Leu Asn Asp Trp Asp Asp Asp Glu Ile Leu Ala Ser 
    530                 535                 540                 


Val Leu Ala Val Ser Gln Gln Glu Tyr Leu Asp Ser Met Lys Lys Asn 
545                 550                 555                 560 


Lys Val His Arg Asp Pro Pro Pro Asp Lys Ser 
                565                 570     


<210> 82
<211> 790
<212> PRT
<213> Homo sapiens

<400> 82
Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu Val Thr Leu Lys Asp Ser Gly Pro Glu Ile Arg Ala 
            260                 265                 270         


Val Pro Leu Val Asn Arg Asp Arg Gly Arg Phe Glu Asp Leu Lys Val 
        275                 280                 285             


His Phe Leu Thr Asp Pro Glu Asn Glu Met Lys Glu Lys Leu Leu Lys 
    290                 295                 300                 


Glu Tyr Leu Met Val Ile Glu Ile Pro Val Gln Gly Trp Asp His Gly 
305                 310                 315                 320 


Thr Thr His Leu Ile Asn Ala Ala Lys Leu Asp Glu Ala Asn Leu Pro 
                325                 330                 335     


Lys Glu Ile Asn Leu Val Asp Asp Tyr Phe Glu Leu Val Gln His Glu 
            340                 345                 350         


Tyr Lys Lys Trp Gln Glu Asn Ser Glu Gln Gly Arg Arg Glu Gly His 
        355                 360                 365             


Ala Gln Asn Pro Met Glu Pro Ser Val Pro Gln Leu Ser Leu Met Asp 
    370                 375                 380                 


Val Lys Cys Glu Thr Pro Asn Cys Pro Phe Phe Met Ser Val Asn Thr 
385                 390                 395                 400 


Gln Pro Leu Cys His Glu Cys Ser Glu Arg Arg Gln Lys Asn Gln Asn 
                405                 410                 415     


Lys Leu Pro Lys Leu Asn Ser Lys Pro Gly Pro Glu Gly Leu Pro Gly 
            420                 425                 430         


Met Ala Leu Gly Ala Ser Arg Gly Glu Ala Tyr Glu Pro Leu Ala Trp 
        435                 440                 445             


Asn Pro Glu Glu Ser Thr Gly Gly Pro His Ser Ala Pro Pro Thr Ala 
    450                 455                 460                 


Pro Ser Pro Phe Leu Phe Ser Glu Thr Thr Ala Met Lys Cys Arg Ser 
465                 470                 475                 480 


Pro Gly Cys Pro Phe Thr Leu Asn Val Gln His Asn Gly Phe Cys Glu 
                485                 490                 495     


Arg Cys His Asn Ala Arg Gln Leu His Ala Ser His Ala Pro Asp His 
            500                 505                 510         


Thr Arg His Leu Asp Pro Gly Lys Cys Gln Ala Cys Leu Gln Asp Val 
        515                 520                 525             


Thr Arg Thr Phe Asn Gly Ile Cys Ser Thr Cys Phe Lys Arg Thr Thr 
    530                 535                 540                 


Ala Glu Ala Ser Ser Ser Leu Ser Thr Ser Leu Pro Pro Ser Cys His 
545                 550                 555                 560 


Gln Arg Ser Lys Ser Asp Pro Ser Arg Leu Val Arg Ser Pro Ser Pro 
                565                 570                 575     


His Ser Cys His Arg Ala Gly Asn Asp Ala Pro Ala Gly Cys Leu Ser 
            580                 585                 590         


Gln Ala Ala Arg Thr Pro Gly Asp Arg Thr Gly Thr Ser Lys Cys Arg 
        595                 600                 605             


Lys Ala Gly Cys Val Tyr Phe Gly Thr Pro Glu Asn Lys Gly Phe Cys 
    610                 615                 620                 


Thr Leu Cys Phe Ile Glu Tyr Arg Glu Asn Lys His Phe Ala Ala Ala 
625                 630                 635                 640 


Ser Gly Lys Val Ser Pro Thr Ala Ser Arg Phe Gln Asn Thr Ile Pro 
                645                 650                 655     


Cys Leu Gly Arg Glu Cys Gly Thr Leu Gly Ser Thr Met Phe Glu Gly 
            660                 665                 670         


Tyr Cys Gln Lys Cys Phe Ile Glu Ala Gln Asn Gln Arg Phe His Glu 
        675                 680                 685             


Ala Lys Arg Thr Glu Glu Gln Leu Arg Ser Ser Gln Arg Arg Asp Val 
    690                 695                 700                 


Pro Arg Thr Thr Gln Ser Thr Ser Arg Pro Lys Cys Ala Arg Ala Ser 
705                 710                 715                 720 


Cys Lys Asn Ile Leu Ala Cys Arg Ser Glu Glu Leu Cys Met Glu Cys 
                725                 730                 735     


Gln His Pro Asn Gln Arg Met Gly Pro Gly Ala His Arg Gly Glu Pro 
            740                 745                 750         


Ala Pro Glu Asp Pro Pro Lys Gln Arg Cys Arg Ala Pro Ala Cys Asp 
        755                 760                 765             


His Phe Gly Asn Ala Lys Cys Asn Gly Tyr Cys Asn Glu Cys Phe Gln 
    770                 775                 780                 


Phe Lys Gln Met Tyr Gly 
785                 790 


<210> 83
<211> 708
<212> PRT
<213> Homo sapiens

<400> 83
Met Ser Glu Arg Gly Ile Lys Trp Ala Cys Glu Tyr Cys Thr Tyr Glu 
1               5                   10                  15      


Asn Trp Pro Ser Ala Ile Lys Cys Thr Met Cys Arg Ala Gln Arg Pro 
            20                  25                  30          


Ser Gly Thr Ile Ile Thr Glu Asp Pro Phe Lys Ser Gly Ser Ser Asp 
        35                  40                  45              


Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly Ser Ser Pro 
    50                  55                  60                  


Leu Ile Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys Ser Ser Tyr 
65                  70                  75                  80  


Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys Thr Tyr Leu 
                85                  90                  95      


Asn Trp Pro Arg Ala Ile Arg Cys Thr Gln Cys Leu Ser Gln Arg Arg 
            100                 105                 110         


Thr Arg Ser Pro Thr Glu Ser Pro Gln Ser Ser Gly Ser Gly Ser Arg 
        115                 120                 125             


Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn Asp Arg Asn 
    130                 135                 140                 


Lys Leu Asn Thr Arg Thr Gln His Trp Thr Cys Ser Val Cys Thr Tyr 
145                 150                 155                 160 


Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp His Pro Arg 
                165                 170                 175     


Pro Asn Asn Ile Glu Ala Ile Glu Leu Ala Glu Thr Glu Glu Ala Ser 
            180                 185                 190         


Ser Ile Ile Asn Glu Gln Asp Arg Ala Arg Trp Arg Gly Ser Cys Ser 
        195                 200                 205             


Ser Gly Asn Ser Gln Arg Arg Ser Pro Pro Ala Thr Lys Arg Asp Ser 
    210                 215                 220                 


Glu Val Lys Met Asp Phe Gln Arg Ile Glu Leu Ala Gly Ala Val Gly 
225                 230                 235                 240 


Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
                245                 250                 255     


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
            260                 265                 270         


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
        275                 280                 285             


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
    290                 295                 300                 


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
305                 310                 315                 320 


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
                325                 330                 335     


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
            340                 345                 350         


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
        355                 360                 365             


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
    370                 375                 380                 


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
385                 390                 395                 400 


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
                405                 410                 415     


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
            420                 425                 430         


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
        435                 440                 445             


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
    450                 455                 460                 


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
465                 470                 475                 480 


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
                485                 490                 495     


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
            500                 505                 510         


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
        515                 520                 525             


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
    530                 535                 540                 


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
545                 550                 555                 560 


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
                565                 570                 575     


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met 
            580                 585                 590         


Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr 
        595                 600                 605             


Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg 
    610                 615                 620                 


Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu 
625                 630                 635                 640 


Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr 
                645                 650                 655     


Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn 
            660                 665                 670         


His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg 
        675                 680                 685             


Gln Ile Arg Pro Cys Thr Ser Leu Ser Asp Gly Glu Glu Asp Glu Asp 
    690                 695                 700                 


Asp Glu Asp Glu 
705             


<210> 84
<211> 1222
<212> PRT
<213> Homo sapiens

<400> 84
Met Ser Gln Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Pro Glu Ala Pro Gln Thr Pro Ser Ser Leu Ala Ser Ala Ala Ala 
            20                  25                  30          


Ser Gly Gly Leu Leu Lys Arg Arg Asp Arg Arg Ile Leu Ser Gly Ser 
        35                  40                  45              


Cys Pro Asp Pro Lys Cys Gln Ala Arg Leu Phe Phe Pro Ala Ser Gly 
    50                  55                  60                  


Ser Val Ser Ile Glu Cys Thr Glu Cys Gly Gln Arg His Glu Gln Gln 
65                  70                  75                  80  


Gln Leu Leu Gly Val Glu Glu Val Thr Asp Pro Asp Val Val Leu His 
                85                  90                  95      


Asn Leu Leu Arg Asn Ala Leu Leu Gly Val Thr Gly Ala Pro Lys Lys 
            100                 105                 110         


Asn Thr Glu Leu Val Lys Val Met Gly Leu Ser Asn Tyr His Cys Lys 
        115                 120                 125             


Leu Leu Ser Pro Ile Leu Ala Arg Tyr Gly Met Asp Lys Gln Thr Gly 
    130                 135                 140                 


Arg Ala Lys Leu Leu Arg Asp Met Asn Gln Gly Glu Leu Phe Asp Cys 
145                 150                 155                 160 


Ala Leu Leu Gly Asp Arg Ala Phe Leu Ile Glu Pro Glu His Val Asn 
                165                 170                 175     


Thr Val Gly Tyr Gly Lys Asp Arg Ser Gly Ser Leu Leu Tyr Leu His 
            180                 185                 190         


Asp Thr Leu Glu Asp Ile Lys Arg Ala Asn Lys Ser Gln Glu Cys Leu 
        195                 200                 205             


Ile Pro Val His Val Asp Gly Asp Gly His Cys Leu Val His Ala Val 
    210                 215                 220                 


Ser Arg Ala Leu Val Gly Arg Glu Leu Phe Trp His Ala Leu Arg Glu 
225                 230                 235                 240 


Asn Leu Lys Gln His Phe Gln Gln His Leu Ala Arg Tyr Gln Ala Leu 
                245                 250                 255     


Phe His Asp Phe Ile Asp Ala Ala Glu Trp Glu Asp Ile Ile Asn Glu 
            260                 265                 270         


Cys Asp Pro Leu Phe Val Pro Pro Glu Gly Val Pro Leu Gly Leu Arg 
        275                 280                 285             


Asn Ile His Ile Phe Gly Leu Ala Asn Val Leu His Arg Pro Ile Ile 
    290                 295                 300                 


Leu Leu Asp Ser Leu Ser Gly Met Arg Ser Ser Gly Asp Tyr Ser Ala 
305                 310                 315                 320 


Thr Phe Leu Pro Gly Leu Ile Pro Ala Glu Lys Cys Thr Gly Lys Asp 
                325                 330                 335     


Gly His Leu Asn Lys Pro Ile Cys Ile Ala Trp Ser Ser Ser Gly Arg 
            340                 345                 350         


Asn His Tyr Ile Pro Leu Val Gly Ile Lys Gly Ala Ala Leu Pro Lys 
        355                 360                 365             


Leu Pro Met Asn Leu Leu Pro Lys Ala Trp Gly Val Pro Gln Asp Leu 
    370                 375                 380                 


Ile Lys Lys Tyr Ile Lys Leu Glu Glu Asp Gly Gly Cys Val Ile Gly 
385                 390                 395                 400 


Gly Asp Arg Ser Leu Gln Asp Lys Tyr Leu Leu Arg Leu Val Ala Ala 
                405                 410                 415     


Met Glu Glu Val Phe Met Asp Lys His Gly Ile His Pro Ser Leu Val 
            420                 425                 430         


Ala Asp Val His Gln Tyr Phe Tyr Arg Arg Thr Gly Val Ile Gly Val 
        435                 440                 445             


Gln Pro Glu Glu Val Thr Ala Ala Ala Lys Lys Ala Val Met Asp Asn 
    450                 455                 460                 


Arg Leu His Lys Cys Leu Leu Cys Gly Ala Leu Ser Glu Leu His Val 
465                 470                 475                 480 


Pro Pro Glu Trp Leu Ala Pro Gly Gly Lys Leu Tyr Asn Leu Ala Lys 
                485                 490                 495     


Ser Thr His Gly Gln Leu Arg Thr Asp Lys Asn Tyr Ser Phe Pro Leu 
            500                 505                 510         


Asn Asn Leu Val Cys Ser Tyr Asp Ser Val Lys Asp Val Leu Val Pro 
        515                 520                 525             


Asp Tyr Gly Met Ser Asn Leu Thr Ala Cys Asn Trp Cys His Gly Thr 
    530                 535                 540                 


Ser Val Arg Lys Val Arg Gly Asp Gly Ser Ile Val Tyr Leu Asp Gly 
545                 550                 555                 560 


Asp Arg Thr Asn Ser Arg Ser Thr Gly Gly Lys Cys Gly Cys Gly Phe 
                565                 570                 575     


Lys His Phe Trp Asp Gly Lys Glu Tyr Asp Asn Leu Pro Glu Ala Phe 
            580                 585                 590         


Pro Ile Thr Leu Glu Trp Gly Gly Arg Val Val Arg Glu Thr Val Tyr 
        595                 600                 605             


Trp Phe Gln Tyr Glu Ser Asp Ser Ser Leu Asn Ser Asn Val Tyr Asp 
    610                 615                 620                 


Val Ala Met Lys Leu Val Thr Lys His Phe Pro Gly Glu Phe Gly Ser 
625                 630                 635                 640 


Glu Ile Leu Val Gln Lys Val Val His Thr Ile Leu His Gln Thr Ala 
                645                 650                 655     


Lys Lys Asn Pro Asp Asp Tyr Thr Pro Val Asn Ile Asp Gly Ala His 
            660                 665                 670         


Ala Gln Arg Val Gly Asp Val Gln Gly Gln Glu Ser Glu Ser Gln Leu 
        675                 680                 685             


Pro Thr Lys Ile Ile Leu Thr Gly Gln Lys Thr Lys Thr Leu His Lys 
    690                 695                 700                 


Glu Glu Leu Asn Met Ser Lys Thr Glu Arg Thr Ile Gln Gln Asn Ile 
705                 710                 715                 720 


Thr Glu Gln Ala Ser Val Met Gln Lys Arg Lys Thr Glu Lys Leu Lys 
                725                 730                 735     


Gln Glu Gln Lys Gly Gln Pro Arg Thr Val Ser Pro Ser Thr Ile Arg 
            740                 745                 750         


Asp Gly Pro Ser Ser Ala Pro Ala Thr Pro Thr Lys Ala Pro Tyr Ser 
        755                 760                 765             


Pro Thr Thr Ser Lys Glu Lys Lys Ile Arg Ile Thr Thr Asn Asp Gly 
    770                 775                 780                 


Arg Gln Ser Met Val Thr Leu Lys Ser Ser Thr Thr Phe Phe Glu Leu 
785                 790                 795                 800 


Gln Glu Ser Ile Ala Arg Glu Phe Asn Ile Pro Pro Tyr Leu Gln Cys 
                805                 810                 815     


Ile Arg Tyr Gly Phe Pro Pro Lys Glu Leu Met Pro Pro Gln Ala Gly 
            820                 825                 830         


Met Glu Lys Glu Pro Val Pro Leu Gln His Gly Asp Arg Ile Thr Ile 
        835                 840                 845             


Glu Ile Leu Lys Ser Lys Ala Glu Gly Gly Gln Ser Ala Ala Ala His 
    850                 855                 860                 


Ser Ala His Thr Val Lys Gln Glu Asp Ile Ala Val Thr Gly Lys Leu 
865                 870                 875                 880 


Ser Ser Lys Glu Leu Gln Glu Gln Ala Glu Lys Glu Met Tyr Ser Leu 
                885                 890                 895     


Cys Leu Leu Ala Thr Leu Met Gly Glu Asp Val Trp Ser Tyr Ala Lys 
            900                 905                 910         


Gly Leu Pro His Met Phe Gln Gln Gly Gly Val Phe Tyr Ser Ile Met 
        915                 920                 925             


Lys Lys Thr Met Gly Met Ala Asp Gly Lys His Cys Thr Phe Pro His 
    930                 935                 940                 


Leu Pro Gly Lys Thr Phe Val Tyr Asn Ala Ser Glu Asp Arg Leu Glu 
945                 950                 955                 960 


Leu Cys Val Asp Ala Ala Gly His Phe Pro Ile Gly Pro Asp Val Glu 
                965                 970                 975     


Asp Leu Val Lys Glu Ala Val Ser Gln Val Arg Ala Glu Ala Thr Thr 
            980                 985                 990         


Arg Ser Arg Glu Ser Ser Pro Ser  His Gly Leu Leu Lys  Leu Gly Ser 
        995                 1000                 1005             


Gly Gly  Val Val Lys Lys Lys  Ser Glu Gln Leu His  Asn Val Thr 
    1010                 1015                 1020             


Ala Phe  Gln Gly Lys Gly His  Ser Leu Gly Thr Ala  Ser Gly Asn 
    1025                 1030                 1035             


Pro His  Leu Asp Pro Arg Ala  Arg Glu Thr Ser Val  Val Arg Lys 
    1040                 1045                 1050             


His Asn  Thr Gly Thr Asp Phe  Ser Asn Ser Ser Thr  Lys Thr Glu 
    1055                 1060                 1065             


Pro Ser  Val Phe Thr Ala Ser  Ser Ser Asn Ser Glu  Leu Ile Arg 
    1070                 1075                 1080             


Ile Ala  Pro Gly Val Val Thr  Met Arg Asp Gly Arg  Gln Leu Asp 
    1085                 1090                 1095             


Pro Asp  Leu Val Glu Ala Gln  Arg Lys Lys Leu Gln  Glu Met Val 
    1100                 1105                 1110             


Ser Ser  Ile Gln Ala Ser Met  Asp Arg His Leu Arg  Asp Gln Ser 
    1115                 1120                 1125             


Thr Glu  Gln Ser Pro Ser Asp  Leu Pro Gln Arg Lys  Thr Glu Val 
    1130                 1135                 1140             


Val Ser  Ser Ser Ala Lys Ser  Gly Ser Leu Gln Thr  Gly Leu Pro 
    1145                 1150                 1155             


Glu Ser  Phe Pro Leu Thr Gly  Gly Thr Glu Asn Leu  Asn Thr Glu 
    1160                 1165                 1170             


Thr Thr  Asp Gly Cys Val Ala  Asp Ala Leu Gly Ala  Ala Phe Ala 
    1175                 1180                 1185             


Thr Arg  Ser Lys Ala Gln Arg  Gly Asn Ser Val Glu  Glu Leu Glu 
    1190                 1195                 1200             


Glu Met  Asp Ser Gln Asp Ala  Glu Met Thr Asn Thr  Thr Glu Pro 
    1205                 1210                 1215             


Met Asp  His Ser 
    1220         


<210> 85
<211> 230
<212> PRT
<213> Homo sapiens

<400> 85
Met Glu Gly Gln Arg Trp Leu Pro Leu Glu Ala Asn Pro Glu Val Thr 
1               5                   10                  15      


Asn Gln Phe Leu Lys Gln Leu Gly Leu His Pro Asn Trp Gln Phe Val 
            20                  25                  30          


Asp Val Tyr Gly Met Asp Pro Glu Leu Leu Ser Met Val Pro Arg Pro 
        35                  40                  45              


Val Cys Ala Val Leu Leu Leu Phe Pro Ile Thr Glu Lys Tyr Glu Val 
    50                  55                  60                  


Phe Arg Thr Glu Glu Glu Glu Lys Ile Lys Ser Gln Gly Gln Asp Val 
65                  70                  75                  80  


Thr Ser Ser Val Tyr Phe Met Lys Gln Thr Ile Ser Asn Ala Cys Gly 
                85                  90                  95      


Thr Ile Gly Leu Ile His Ala Ile Ala Asn Asn Lys Asp Lys Met His 
            100                 105                 110         


Phe Glu Ser Gly Ser Thr Leu Lys Lys Phe Leu Glu Glu Ser Val Ser 
        115                 120                 125             


Met Ser Pro Glu Glu Arg Ala Arg Tyr Leu Glu Asn Tyr Asp Ala Ile 
    130                 135                 140                 


Arg Val Thr His Glu Thr Ser Ala His Glu Gly Gln Thr Glu Ala Pro 
145                 150                 155                 160 


Ser Ile Asp Glu Lys Val Asp Leu His Phe Ile Ala Leu Val His Val 
                165                 170                 175     


Asp Gly His Leu Tyr Glu Leu Asp Gly Arg Lys Pro Phe Pro Ile Asn 
            180                 185                 190         


His Gly Glu Thr Ser Asp Glu Thr Leu Leu Glu Asp Ala Ile Glu Val 
        195                 200                 205             


Cys Lys Lys Phe Met Glu Arg Asp Pro Asp Glu Leu Arg Phe Asn Ala 
    210                 215                 220                 


Ile Ala Leu Ser Ala Ala 
225                 230 


<210> 86
<211> 223
<212> PRT
<213> Homo sapiens

<400> 86
Met Gln Leu Lys Pro Met Glu Ile Asn Pro Glu Met Leu Asn Lys Val 
1               5                   10                  15      


Leu Ser Arg Leu Gly Val Ala Gly Gln Trp Arg Phe Val Asp Val Leu 
            20                  25                  30          


Gly Leu Glu Glu Glu Ser Leu Gly Ser Val Pro Ala Pro Ala Cys Ala 
        35                  40                  45              


Leu Leu Leu Leu Phe Pro Leu Thr Ala Gln His Glu Asn Phe Arg Lys 
    50                  55                  60                  


Lys Gln Ile Glu Glu Leu Lys Gly Gln Glu Val Ser Pro Lys Val Tyr 
65                  70                  75                  80  


Phe Met Lys Gln Thr Ile Gly Asn Ser Cys Gly Thr Ile Gly Leu Ile 
                85                  90                  95      


His Ala Val Ala Asn Asn Gln Asp Lys Leu Gly Phe Glu Asp Gly Ser 
            100                 105                 110         


Val Leu Lys Gln Phe Leu Ser Glu Thr Glu Lys Met Ser Pro Glu Asp 
        115                 120                 125             


Arg Ala Lys Cys Phe Glu Lys Asn Glu Ala Ile Gln Ala Ala His Asp 
    130                 135                 140                 


Ala Val Ala Gln Glu Gly Gln Cys Arg Val Asp Asp Lys Val Asn Phe 
145                 150                 155                 160 


His Phe Ile Leu Phe Asn Asn Val Asp Gly His Leu Tyr Glu Leu Asp 
                165                 170                 175     


Gly Arg Met Pro Phe Pro Val Asn His Gly Ala Ser Ser Glu Asp Thr 
            180                 185                 190         


Leu Leu Lys Asp Ala Ala Lys Val Cys Arg Glu Phe Thr Glu Arg Glu 
        195                 200                 205             


Gln Gly Glu Val Arg Phe Ser Ala Val Ala Leu Cys Lys Ala Ala 
    210                 215                 220             


<210> 87
<211> 329
<212> PRT
<213> Homo sapiens

<400> 87
Met Thr Gly Asn Ala Gly Glu Trp Cys Leu Met Glu Ser Asp Pro Gly 
1               5                   10                  15      


Val Phe Thr Glu Leu Ile Lys Gly Phe Gly Cys Arg Gly Ala Gln Val 
            20                  25                  30          


Glu Glu Ile Trp Ser Leu Glu Pro Glu Asn Phe Glu Lys Leu Lys Pro 
        35                  40                  45              


Val His Gly Leu Ile Phe Leu Phe Lys Trp Gln Pro Gly Glu Glu Pro 
    50                  55                  60                  


Ala Gly Ser Val Val Gln Asp Ser Arg Leu Asp Thr Ile Phe Phe Ala 
65                  70                  75                  80  


Lys Gln Val Ile Asn Asn Ala Cys Ala Thr Gln Ala Ile Val Ser Val 
                85                  90                  95      


Leu Leu Asn Cys Thr His Gln Asp Val His Leu Gly Glu Thr Leu Ser 
            100                 105                 110         


Glu Phe Lys Glu Phe Ser Gln Ser Phe Asp Ala Ala Met Lys Gly Leu 
        115                 120                 125             


Ala Leu Ser Asn Ser Asp Val Ile Arg Gln Val His Asn Ser Phe Ala 
    130                 135                 140                 


Arg Gln Gln Met Phe Glu Phe Asp Thr Lys Thr Ser Ala Lys Glu Glu 
145                 150                 155                 160 


Asp Ala Phe His Phe Val Ser Tyr Val Pro Val Asn Gly Arg Leu Tyr 
                165                 170                 175     


Glu Leu Asp Gly Leu Arg Glu Gly Pro Ile Asp Leu Gly Ala Cys Asn 
            180                 185                 190         


Gln Asp Asp Trp Ile Ser Ala Val Arg Pro Val Ile Glu Lys Arg Ile 
        195                 200                 205             


Gln Lys Tyr Ser Glu Gly Glu Ile Arg Phe Asn Leu Met Ala Ile Val 
    210                 215                 220                 


Ser Asp Arg Lys Met Ile Tyr Glu Gln Lys Ile Ala Glu Leu Gln Arg 
225                 230                 235                 240 


Gln Leu Ala Glu Glu Glu Pro Met Asp Thr Asp Gln Gly Asn Ser Met 
                245                 250                 255     


Leu Ser Ala Ile Gln Ser Glu Val Ala Lys Asn Gln Met Leu Ile Glu 
            260                 265                 270         


Glu Glu Val Gln Lys Leu Lys Arg Tyr Lys Ile Glu Asn Ile Arg Arg 
        275                 280                 285             


Lys His Asn Tyr Leu Pro Phe Ile Met Glu Leu Leu Lys Thr Leu Ala 
    290                 295                 300                 


Glu His Gln Gln Leu Ile Pro Leu Val Glu Lys Ala Lys Glu Lys Gln 
305                 310                 315                 320 


Asn Ala Lys Lys Ala Gln Glu Thr Lys 
                325                 


<210> 88
<211> 361
<212> PRT
<213> Homo sapiens

<400> 88
Met Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Gly Asn Met Asp Asp Ser Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn Ser 
                85                  90                  95      


Pro Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly Lys 
        115                 120                 125             


Gln Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly Tyr 
145                 150                 155                 160 


Ser Ile Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Met Ile Arg Val Gln Gln Met His Arg Pro Lys Leu Ile 
            180                 185                 190         


Gly Glu Glu Leu Ala Gln Leu Lys Glu Gln Arg Val His Lys Thr Asp 
        195                 200                 205             


Leu Glu Arg Val Leu Glu Ala Asn Asp Gly Ser Gly Met Leu Asp Glu 
    210                 215                 220                 


Asp Glu Glu Asp Leu Gln Arg Ala Leu Ala Leu Ser Arg Gln Glu Ile 
225                 230                 235                 240 


Asp Met Glu Asp Glu Glu Ala Asp Leu Arg Arg Ala Ile Gln Leu Ser 
                245                 250                 255     


Met Gln Gly Ser Ser Arg Asn Ile Ser Gln Asp Met Thr Gln Thr Ser 
            260                 265                 270         


Gly Thr Asn Leu Thr Ser Glu Glu Leu Arg Lys Arg Arg Glu Ala Tyr 
        275                 280                 285             


Phe Glu Lys Gln Gln Gln Lys Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    290                 295                 300                 


Gln Gly Asp Leu Ser Gly Gln Ser Ser His Pro Cys Glu Arg Pro Ala 
305                 310                 315                 320 


Thr Ser Ser Gly Ala Leu Gly Ser Asp Leu Gly Asp Ala Met Ser Glu 
                325                 330                 335     


Glu Asp Met Leu Gln Ala Ala Val Thr Met Ser Leu Glu Thr Val Arg 
            340                 345                 350         


Asn Asp Leu Lys Thr Glu Gly Lys Lys 
        355                 360     


<210> 89
<211> 188
<212> PRT
<213> Homo sapiens

<400> 89
Met Ser Gln Ala Pro Gly Ala Gln Pro Ser Pro Pro Thr Val Tyr His 
1               5                   10                  15      


Glu Arg Gln Arg Leu Glu Leu Cys Ala Val His Ala Leu Asn Asn Val 
            20                  25                  30          


Leu Gln Gln Gln Leu Phe Ser Gln Glu Ala Ala Asp Glu Ile Cys Lys 
        35                  40                  45              


Arg Leu Ala Pro Asp Ser Arg Leu Asn Pro His Arg Ser Leu Leu Gly 
    50                  55                  60                  


Thr Gly Asn Tyr Asp Val Asn Val Ile Met Ala Ala Leu Gln Gly Leu 
65                  70                  75                  80  


Gly Leu Ala Ala Val Trp Trp Asp Arg Arg Arg Pro Leu Ser Gln Leu 
                85                  90                  95      


Ala Leu Pro Gln Val Leu Gly Leu Ile Leu Asn Leu Pro Ser Pro Val 
            100                 105                 110         


Ser Leu Gly Leu Leu Ser Leu Pro Leu Arg Arg Arg His Trp Val Ala 
        115                 120                 125             


Leu Arg Gln Val Asp Gly Val Tyr Tyr Asn Leu Asp Ser Lys Leu Arg 
    130                 135                 140                 


Ala Pro Glu Ala Leu Gly Asp Glu Asp Gly Val Arg Ala Phe Leu Ala 
145                 150                 155                 160 


Ala Ala Leu Ala Gln Gly Leu Cys Glu Val Leu Leu Val Val Thr Lys 
                165                 170                 175     


Glu Val Glu Glu Lys Gly Ser Trp Leu Arg Thr Asp 
            180                 185             


<210> 90
<211> 202
<212> PRT
<213> Homo sapiens

<400> 90
Met Ser Cys Val Pro Trp Lys Gly Asp Lys Ala Lys Ser Glu Ser Leu 
1               5                   10                  15      


Glu Leu Pro Gln Ala Ala Pro Pro Gln Ile Tyr His Glu Lys Gln Arg 
            20                  25                  30          


Arg Glu Leu Cys Ala Leu His Ala Leu Asn Asn Val Phe Gln Asp Ser 
        35                  40                  45              


Asn Ala Phe Thr Arg Asp Thr Leu Gln Glu Ile Phe Gln Arg Leu Ser 
    50                  55                  60                  


Pro Asn Thr Met Val Thr Pro His Lys Lys Ser Met Leu Gly Asn Gly 
65                  70                  75                  80  


Asn Tyr Asp Val Asn Val Ile Met Ala Ala Leu Gln Thr Lys Gly Tyr 
                85                  90                  95      


Glu Ala Val Trp Trp Asp Lys Arg Arg Asp Val Gly Val Ile Ala Leu 
            100                 105                 110         


Thr Asn Val Met Gly Phe Ile Met Asn Leu Pro Ser Ser Leu Cys Trp 
        115                 120                 125             


Gly Pro Leu Lys Leu Pro Leu Lys Arg Gln His Trp Ile Cys Val Arg 
    130                 135                 140                 


Glu Val Gly Gly Ala Tyr Tyr Asn Leu Asp Ser Lys Leu Lys Met Pro 
145                 150                 155                 160 


Glu Trp Ile Gly Gly Glu Ser Glu Leu Arg Lys Phe Leu Lys His His 
                165                 170                 175     


Leu Arg Gly Lys Asn Cys Glu Leu Leu Leu Val Val Pro Glu Glu Val 
            180                 185                 190         


Glu Ala His Gln Ser Trp Arg Thr Asp Val 
        195                 200         


<210> 91
<211> 355
<212> PRT
<213> Homo sapiens

<400> 91
Met Asp Phe Ile Phe His Glu Lys Gln Glu Gly Phe Leu Cys Ala Gln 
1               5                   10                  15      


His Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu 
            20                  25                  30          


Leu Ala Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met 
        35                  40                  45              


Ala Glu Gly Gly Val Thr Ser Glu Glu Tyr Leu Ala Phe Leu Gln Gln 
    50                  55                  60                  


Pro Ser Glu Asn Met Asp Asp Thr Gly Phe Phe Ser Ile Gln Val Ile 
65                  70                  75                  80  


Ser Asn Ala Leu Lys Phe Trp Gly Leu Glu Ile Ile His Phe Asn Asn 
                85                  90                  95      


Pro Glu Tyr Gln Lys Leu Gly Ile Asp Pro Ile Asn Glu Arg Ser Phe 
            100                 105                 110         


Ile Cys Asn Tyr Lys Gln His Trp Phe Thr Ile Arg Lys Phe Gly Lys 
        115                 120                 125             


His Trp Phe Asn Leu Asn Ser Leu Leu Ala Gly Pro Glu Leu Ile Ser 
    130                 135                 140                 


Asp Thr Cys Leu Ala Asn Phe Leu Ala Arg Leu Gln Gln Gln Ala Tyr 
145                 150                 155                 160 


Ser Val Phe Val Val Lys Gly Asp Leu Pro Asp Cys Glu Ala Asp Gln 
                165                 170                 175     


Leu Leu Gln Ile Ile Ser Val Glu Glu Met Asp Thr Pro Lys Leu Asn 
            180                 185                 190         


Gly Lys Lys Leu Val Lys Gln Lys Glu His Arg Val Tyr Lys Thr Val 
        195                 200                 205             


Leu Glu Lys Val Ser Glu Glu Ser Asp Glu Ser Gly Thr Ser Asp Gln 
    210                 215                 220                 


Asp Glu Glu Asp Phe Gln Arg Ala Leu Glu Leu Ser Arg Gln Glu Thr 
225                 230                 235                 240 


Asn Arg Glu Asp Glu His Leu Arg Ser Thr Ile Glu Leu Ser Met Gln 
                245                 250                 255     


Gly Ser Ser Gly Asn Thr Ser Gln Asp Leu Pro Lys Thr Ser Cys Val 
            260                 265                 270         


Thr Pro Ala Ser Glu Gln Pro Lys Lys Ile Lys Glu Asp Tyr Phe Glu 
        275                 280                 285             


Lys His Gln Gln Glu Gln Lys Gln Gln Gln Gln Gln Ser Asp Leu Pro 
    290                 295                 300                 


Gly His Ser Ser Tyr Leu His Glu Arg Pro Thr Thr Ser Ser Arg Ala 
305                 310                 315                 320 


Ile Glu Ser Asp Leu Ser Asp Asp Ile Ser Glu Gly Thr Val Gln Ala 
                325                 330                 335     


Ala Val Asp Thr Ile Leu Glu Ile Met Arg Lys Asn Leu Lys Ile Lys 
            340                 345                 350         


Gly Glu Lys 
        355 


<210> 92
<211> 445
<212> PRT
<213> Homo sapiens

<400> 92
Met Ser Glu Leu Thr Lys Glu Leu Met Glu Leu Val Trp Gly Thr Lys 
1               5                   10                  15      


Ser Ser Pro Gly Leu Ser Asp Thr Ile Phe Cys Arg Trp Thr Gln Gly 
            20                  25                  30          


Phe Val Phe Ser Glu Ser Glu Gly Ser Ala Leu Glu Gln Phe Glu Gly 
        35                  40                  45              


Gly Pro Cys Ala Val Ile Ala Pro Val Gln Ala Phe Leu Leu Lys Lys 
    50                  55                  60                  


Leu Leu Phe Ser Ser Glu Lys Ser Ser Trp Arg Asp Cys Ser Glu Glu 
65                  70                  75                  80  


Glu Gln Lys Glu Leu Leu Cys His Thr Leu Cys Asp Ile Leu Glu Ser 
                85                  90                  95      


Ala Cys Cys Asp His Ser Gly Ser Tyr Cys Leu Val Ser Trp Leu Arg 
            100                 105                 110         


Gly Lys Thr Thr Glu Glu Thr Ala Ser Ile Ser Gly Ser Pro Ala Glu 
        115                 120                 125             


Ser Ser Cys Gln Val Glu His Ser Ser Ala Leu Ala Val Glu Glu Leu 
    130                 135                 140                 


Gly Phe Glu Arg Phe His Ala Leu Ile Gln Lys Arg Ser Phe Arg Ser 
145                 150                 155                 160 


Leu Pro Glu Leu Lys Asp Ala Val Leu Asp Gln Tyr Ser Met Trp Gly 
                165                 170                 175     


Asn Lys Phe Gly Val Leu Leu Phe Leu Tyr Ser Val Leu Leu Thr Lys 
            180                 185                 190         


Gly Ile Glu Asn Ile Lys Asn Glu Ile Glu Asp Ala Ser Glu Pro Leu 
        195                 200                 205             


Ile Asp Pro Val Tyr Gly His Gly Ser Gln Ser Leu Ile Asn Leu Leu 
    210                 215                 220                 


Leu Thr Gly His Ala Val Ser Asn Val Trp Asp Gly Asp Arg Glu Cys 
225                 230                 235                 240 


Ser Gly Met Lys Leu Leu Gly Ile His Glu Gln Ala Ala Val Gly Phe 
                245                 250                 255     


Leu Thr Leu Met Glu Ala Leu Arg Tyr Cys Lys Val Gly Ser Tyr Leu 
            260                 265                 270         


Lys Ser Pro Lys Phe Pro Ile Trp Ile Val Gly Ser Glu Thr His Leu 
        275                 280                 285             


Thr Val Phe Phe Ala Lys Asp Met Ala Leu Val Ala Pro Glu Ala Pro 
    290                 295                 300                 


Ser Glu Gln Ala Arg Arg Val Phe Gln Thr Tyr Asp Pro Glu Asp Asn 
305                 310                 315                 320 


Gly Phe Ile Pro Asp Ser Leu Leu Glu Asp Val Met Lys Ala Leu Asp 
                325                 330                 335     


Leu Val Ser Asp Pro Glu Tyr Ile Asn Leu Met Lys Asn Lys Leu Asp 
            340                 345                 350         


Pro Glu Gly Leu Gly Ile Ile Leu Leu Gly Pro Phe Leu Gln Glu Phe 
        355                 360                 365             


Phe Pro Asp Gln Gly Ser Ser Gly Pro Glu Ser Phe Thr Val Tyr His 
    370                 375                 380                 


Tyr Asn Gly Leu Lys Gln Ser Asn Tyr Asn Glu Lys Val Met Tyr Val 
385                 390                 395                 400 


Glu Gly Thr Ala Val Val Met Gly Phe Glu Asp Pro Met Leu Gln Thr 
                405                 410                 415     


Asp Asp Thr Pro Ile Lys Arg Cys Leu Gln Thr Lys Trp Pro Tyr Ile 
            420                 425                 430         


Glu Leu Leu Trp Thr Thr Asp Arg Ser Pro Ser Leu Asn 
        435                 440                 445 


<210> 93
<211> 469
<212> PRT
<213> Homo sapiens

<400> 93
Met Glu Tyr His Gln Pro Glu Asp Pro Ala Pro Gly Lys Ala Gly Thr 
1               5                   10                  15      


Ala Glu Ala Val Ile Pro Glu Asn His Glu Val Leu Ala Gly Pro Asp 
            20                  25                  30          


Glu His Pro Gln Asp Thr Asp Ala Arg Asp Ala Asp Gly Glu Ala Arg 
        35                  40                  45              


Glu Arg Glu Pro Ala Asp Gln Ala Leu Leu Pro Ser Gln Cys Gly Asp 
    50                  55                  60                  


Asn Leu Glu Ser Pro Leu Pro Glu Ala Ser Ser Ala Pro Pro Gly Pro 
65                  70                  75                  80  


Thr Leu Gly Thr Leu Pro Glu Val Glu Thr Ile Arg Ala Cys Ser Met 
                85                  90                  95      


Pro Gln Glu Leu Pro Gln Ser Pro Arg Thr Arg Gln Pro Glu Pro Asp 
            100                 105                 110         


Phe Tyr Cys Val Lys Trp Ile Pro Trp Lys Gly Glu Gln Thr Pro Ile 
        115                 120                 125             


Ile Thr Gln Ser Thr Asn Gly Pro Cys Pro Leu Leu Ala Ile Met Asn 
    130                 135                 140                 


Ile Leu Phe Leu Gln Trp Lys Val Lys Leu Pro Pro Gln Lys Glu Val 
145                 150                 155                 160 


Ile Thr Ser Asp Glu Leu Met Ala His Leu Gly Asn Cys Leu Leu Ser 
                165                 170                 175     


Ile Lys Pro Gln Glu Lys Ser Glu Gly Leu Gln Leu Asn Phe Gln Gln 
            180                 185                 190         


Asn Val Asp Asp Ala Met Thr Val Leu Pro Lys Leu Ala Thr Gly Leu 
        195                 200                 205             


Asp Val Asn Val Arg Phe Thr Gly Val Ser Asp Phe Glu Tyr Thr Pro 
    210                 215                 220                 


Glu Cys Ser Val Phe Asp Leu Leu Gly Ile Pro Leu Tyr His Gly Trp 
225                 230                 235                 240 


Leu Val Asp Pro Gln Ser Pro Glu Ala Val Arg Ala Val Gly Lys Leu 
                245                 250                 255     


Ser Tyr Asn Gln Leu Val Glu Arg Ile Ile Thr Cys Lys His Ser Ser 
            260                 265                 270         


Asp Thr Asn Leu Val Thr Glu Gly Leu Ile Ala Glu Gln Phe Leu Glu 
        275                 280                 285             


Thr Thr Ala Ala Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ala 
    290                 295                 300                 


Ala Ala Lys Glu Gly Glu Leu Ser Val Phe Phe Arg Asn Asn His Phe 
305                 310                 315                 320 


Ser Thr Met Thr Lys His Lys Ser His Leu Tyr Leu Leu Val Thr Asp 
                325                 330                 335     


Gln Gly Phe Leu Gln Glu Glu Gln Val Val Trp Glu Ser Leu His Asn 
            340                 345                 350         


Val Asp Gly Asp Ser Cys Phe Cys Asp Ser Asp Phe His Leu Ser His 
        355                 360                 365             


Ser Leu Gly Lys Gly Pro Gly Ala Glu Gly Gly Ser Gly Ser Pro Glu 
    370                 375                 380                 


Thr Gln Leu Gln Val Asp Gln Asp Tyr Leu Ile Ala Leu Ser Leu Gln 
385                 390                 395                 400 


Gln Gln Gln Pro Arg Gly Pro Leu Gly Leu Thr Asp Leu Glu Leu Ala 
                405                 410                 415     


Gln Gln Leu Gln Gln Glu Glu Tyr Gln Gln Gln Gln Ala Ala Gln Pro 
            420                 425                 430         


Val Arg Met Arg Thr Arg Val Leu Ser Leu Gln Gly Arg Gly Ala Thr 
        435                 440                 445             


Ser Gly Arg Pro Ala Gly Glu Arg Arg Gln Arg Pro Lys His Glu Ser 
    450                 455                 460                 


Asp Cys Ile Leu Leu 
465                 


<210> 94
<211> 621
<212> PRT
<213> Homo sapiens

<400> 94
Met Glu Ser Ser Pro Glu Ser Leu Gln Pro Leu Glu His Gly Val Ala 
1               5                   10                  15      


Ala Gly Pro Ala Ser Gly Thr Gly Ser Ser Gln Glu Gly Leu Gln Glu 
            20                  25                  30          


Thr Arg Leu Ala Ala Gly Asp Gly Pro Gly Val Trp Ala Ala Glu Thr 
        35                  40                  45              


Ser Gly Gly Asn Gly Leu Gly Ala Ala Ala Ala Arg Arg Ser Leu Pro 
    50                  55                  60                  


Asp Ser Ala Ser Pro Ala Gly Ser Pro Glu Val Pro Gly Pro Cys Ser 
65                  70                  75                  80  


Ser Ser Ala Gly Leu Asp Leu Lys Asp Ser Gly Leu Glu Ser Pro Ala 
                85                  90                  95      


Ala Ala Glu Ala Pro Leu Arg Gly Gln Tyr Lys Val Thr Ala Ser Pro 
            100                 105                 110         


Glu Thr Ala Val Ala Gly Val Gly His Glu Leu Gly Thr Ala Gly Asp 
        115                 120                 125             


Ala Gly Ala Arg Pro Asp Leu Ala Gly Thr Cys Gln Ala Glu Leu Thr 
    130                 135                 140                 


Ala Ala Gly Ser Glu Glu Pro Ser Ser Ala Gly Gly Leu Ser Ser Ser 
145                 150                 155                 160 


Cys Ser Asp Pro Ser Pro Pro Gly Glu Ser Pro Ser Leu Asp Ser Leu 
                165                 170                 175     


Glu Ser Phe Ser Asn Leu His Ser Phe Pro Ser Ser Cys Glu Phe Asn 
            180                 185                 190         


Ser Glu Glu Gly Ala Glu Asn Arg Val Pro Glu Glu Glu Glu Gly Ala 
        195                 200                 205             


Ala Val Leu Pro Gly Ala Val Pro Leu Cys Lys Glu Glu Glu Gly Glu 
    210                 215                 220                 


Glu Thr Ala Gln Val Leu Ala Ala Ser Lys Glu Arg Phe Pro Gly Gln 
225                 230                 235                 240 


Ser Val Tyr His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro 
                245                 250                 255     


Ile Ile Thr Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu 
            260                 265                 270         


Asn Val Leu Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu 
        275                 280                 285             


Ile Ile Thr Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu 
    290                 295                 300                 


Asp Ala Lys Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu 
305                 310                 315                 320 


Gln Asn Met Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly 
                325                 330                 335     


Leu Asp Val Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr 
            340                 345                 350         


Pro Glu Cys Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly 
        355                 360                 365             


Trp Leu Val Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn 
    370                 375                 380                 


Cys Ser Tyr Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser 
385                 390                 395                 400 


Asp Asn Ser Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu 
                405                 410                 415     


Asn Asn Thr Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr 
            420                 425                 430         


Ser Thr Val Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His 
        435                 440                 445             


Phe Ser Thr Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr 
    450                 455                 460                 


Asp Gln Gly Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His 
465                 470                 475                 480 


Asn Val Asp Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg 
                485                 490                 495     


Pro Pro Ser Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile 
            500                 505                 510         


Asp Gln Asp Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser 
        515                 520                 525             


Gln Glu Ile Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu 
    530                 535                 540                 


Leu Ala Lys Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr 
545                 550                 555                 560 


Tyr Gln Glu Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr 
                565                 570                 575     


Gln Ala Gln Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg 
            580                 585                 590         


Gln Ser Gly Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp 
        595                 600                 605             


Lys Glu Lys Glu Lys Glu Lys Asn Ser Cys Val Ile Leu 
    610                 615                 620     


<210> 95
<211> 757
<212> PRT
<213> Homo sapiens

<400> 95
Met Asp Ser Leu Phe Val Glu Glu Val Ala Ala Ser Leu Val Arg Glu 
1               5                   10                  15      


Phe Leu Ser Arg Lys Gly Leu Lys Lys Thr Cys Val Thr Met Asp Gln 
            20                  25                  30          


Glu Arg Pro Arg Ser Asp Leu Ser Ile Asn Asn Arg Asn Asp Leu Arg 
        35                  40                  45              


Lys Val Leu His Leu Glu Phe Leu Tyr Lys Glu Asn Lys Ala Lys Glu 
    50                  55                  60                  


Asn Pro Leu Lys Thr Ser Leu Glu Leu Ile Thr Arg Tyr Phe Leu Asp 
65                  70                  75                  80  


His Phe Gly Asn Thr Ala Asn Asn Phe Thr Gln Asp Thr Pro Ile Pro 
                85                  90                  95      


Ala Leu Ser Val Pro Lys Lys Asn Asn Lys Val Pro Ser Arg Cys Ser 
            100                 105                 110         


Glu Thr Thr Leu Val Asn Ile Tyr Asp Leu Ser Asp Glu Asp Ala Gly 
        115                 120                 125             


Trp Arg Thr Ser Leu Ser Glu Thr Ser Lys Ala Arg His Asp Asn Leu 
    130                 135                 140                 


Asp Gly Asp Val Leu Gly Asn Phe Val Ser Ser Lys Arg Pro Pro His 
145                 150                 155                 160 


Lys Ser Lys Pro Met Gln Thr Val Pro Gly Glu Thr Pro Val Leu Thr 
                165                 170                 175     


Ser Ala Trp Glu Lys Ile Asp Lys Leu His Ser Glu Pro Ser Leu Asp 
            180                 185                 190         


Val Lys Arg Met Gly Glu Asn Ser Arg Pro Lys Ser Gly Leu Ile Val 
        195                 200                 205             


Arg Gly Met Met Ser Gly Pro Ile Ala Ser Ser Pro Gln Asp Ser Phe 
    210                 215                 220                 


His Arg His Tyr Leu Arg Arg Ser Ser Pro Ser Ser Ser Ser Thr Gln 
225                 230                 235                 240 


Pro Gln Glu Glu Ser Arg Lys Val Pro Glu Leu Phe Val Cys Thr Gln 
                245                 250                 255     


Gln Asp Ile Leu Ala Ser Ser Asn Ser Ser Pro Ser Arg Thr Ser Leu 
            260                 265                 270         


Gly Gln Leu Ser Glu Leu Thr Val Glu Arg Gln Lys Thr Thr Ala Ser 
        275                 280                 285             


Ser Pro Pro His Leu Pro Ser Lys Arg Leu Pro Pro Trp Asp Arg Ala 
    290                 295                 300                 


Arg Pro Arg Asp Pro Ser Glu Asp Thr Pro Ala Val Asp Gly Ser Thr 
305                 310                 315                 320 


Asp Thr Asp Arg Met Pro Leu Lys Leu Tyr Leu Pro Gly Gly Asn Ser 
                325                 330                 335     


Arg Met Thr Gln Glu Arg Leu Glu Arg Ala Phe Lys Arg Gln Gly Ser 
            340                 345                 350         


Gln Pro Ala Pro Val Arg Lys Asn Gln Leu Leu Pro Ser Asp Lys Val 
        355                 360                 365             


Asp Gly Glu Leu Gly Ala Leu Arg Leu Glu Asp Val Glu Asp Glu Leu 
    370                 375                 380                 


Ile Arg Glu Glu Val Ile Leu Ser Pro Val Pro Ser Val Leu Lys Leu 
385                 390                 395                 400 


Gln Thr Ala Ser Lys Pro Ile Asp Leu Ser Val Ala Lys Glu Ile Lys 
                405                 410                 415     


Thr Leu Leu Phe Gly Ser Ser Phe Cys Cys Phe Asn Glu Glu Trp Lys 
            420                 425                 430         


Leu Gln Ser Phe Ser Phe Ser Asn Thr Ala Ser Leu Lys Tyr Gly Ile 
        435                 440                 445             


Val Gln Asn Lys Gly Gly Pro Cys Gly Val Leu Ala Ala Val Gln Gly 
    450                 455                 460                 


Cys Val Leu Gln Lys Leu Leu Phe Glu Gly Asp Ser Lys Ala Asp Cys 
465                 470                 475                 480 


Ala Gln Gly Leu Gln Pro Ser Asp Ala His Arg Thr Arg Cys Leu Val 
                485                 490                 495     


Leu Ala Leu Ala Asp Ile Val Trp Arg Ala Gly Gly Arg Glu Arg Ala 
            500                 505                 510         


Val Val Ala Leu Ala Ser Arg Thr Gln Gln Phe Ser Pro Thr Gly Lys 
        515                 520                 525             


Tyr Lys Ala Asp Gly Val Leu Glu Thr Leu Thr Leu His Ser Leu Thr 
    530                 535                 540                 


Cys Tyr Glu Asp Leu Val Thr Phe Leu Gln Gln Ser Ile His Gln Phe 
545                 550                 555                 560 


Glu Val Gly Pro Tyr Gly Cys Ile Leu Leu Thr Leu Ser Ala Ile Leu 
                565                 570                 575     


Ser Arg Ser Thr Glu Leu Ile Arg Gln Asp Phe Asp Val Pro Thr Ser 
            580                 585                 590         


His Leu Ile Gly Ala His Gly Tyr Cys Thr Gln Glu Leu Val Asn Leu 
        595                 600                 605             


Leu Leu Thr Gly Lys Ala Val Ser Asn Val Phe Asn Asp Val Val Glu 
    610                 615                 620                 


Leu Asp Ser Gly Asp Gly Asn Ile Thr Leu Leu Arg Gly Ile Ala Ala 
625                 630                 635                 640 


Arg Ser Asp Ile Gly Phe Leu Ser Leu Phe Glu His Tyr Asn Met Cys 
                645                 650                 655     


Gln Val Gly Cys Phe Leu Lys Thr Pro Arg Phe Pro Ile Trp Val Val 
            660                 665                 670         


Cys Ser Glu Ser His Phe Ser Ile Leu Phe Ser Leu Gln Pro Gly Leu 
        675                 680                 685             


Leu Arg Asp Trp Arg Thr Glu Arg Leu Phe Asp Leu Tyr Tyr Tyr Asp 
    690                 695                 700                 


Gly Leu Ala Asn Gln Gln Glu Gln Ile Arg Leu Thr Ile Asp Thr Thr 
705                 710                 715                 720 


Gln Thr Ile Ser Glu Asp Thr Asp Asn Asp Leu Val Pro Pro Leu Glu 
                725                 730                 735     


Leu Cys Ile Arg Thr Lys Trp Lys Gly Ala Ser Val Asn Trp Asn Gly 
            740                 745                 750         


Ser Asp Pro Ile Leu 
        755         


<210> 96
<211> 424
<212> PRT
<213> Homo sapiens

<400> 96
Met Ser Asp His Gly Asp Val Ser Leu Pro Pro Glu Asp Arg Val Arg 
1               5                   10                  15      


Ala Leu Ser Gln Leu Gly Ser Ala Val Glu Val Asn Glu Asp Ile Pro 
            20                  25                  30          


Pro Arg Arg Tyr Phe Arg Ser Gly Val Glu Ile Ile Arg Met Ala Ser 
        35                  40                  45              


Ile Tyr Ser Glu Glu Gly Asn Ile Glu His Ala Phe Ile Leu Tyr Asn 
    50                  55                  60                  


Lys Tyr Ile Thr Leu Phe Ile Glu Lys Leu Pro Lys His Arg Asp Tyr 
65                  70                  75                  80  


Lys Ser Ala Val Ile Pro Glu Lys Lys Asp Thr Val Lys Lys Leu Lys 
                85                  90                  95      


Glu Ile Ala Phe Pro Lys Ala Glu Glu Leu Lys Ala Glu Leu Leu Lys 
            100                 105                 110         


Arg Tyr Thr Lys Glu Tyr Thr Glu Tyr Asn Glu Glu Lys Lys Lys Glu 
        115                 120                 125             


Ala Glu Glu Leu Ala Arg Asn Met Ala Ile Gln Gln Glu Leu Glu Lys 
    130                 135                 140                 


Glu Lys Gln Arg Val Ala Gln Gln Lys Gln Gln Gln Leu Glu Gln Glu 
145                 150                 155                 160 


Gln Phe His Ala Phe Glu Glu Met Ile Arg Asn Gln Glu Leu Glu Lys 
                165                 170                 175     


Glu Arg Leu Lys Ile Val Gln Glu Phe Gly Lys Val Asp Pro Gly Leu 
            180                 185                 190         


Gly Gly Pro Leu Val Pro Asp Leu Glu Lys Pro Ser Leu Asp Val Phe 
        195                 200                 205             


Pro Thr Leu Thr Val Ser Ser Ile Gln Pro Ser Asp Cys His Thr Thr 
    210                 215                 220                 


Val Arg Pro Ala Lys Pro Pro Val Val Asp Arg Ser Leu Lys Pro Gly 
225                 230                 235                 240 


Ala Leu Ser Asn Ser Glu Ser Ile Pro Thr Ile Asp Gly Leu Arg His 
                245                 250                 255     


Val Val Val Pro Gly Arg Leu Cys Pro Gln Phe Leu Gln Leu Ala Ser 
            260                 265                 270         


Ala Asn Thr Ala Arg Gly Val Glu Thr Cys Gly Ile Leu Cys Gly Lys 
        275                 280                 285             


Leu Met Arg Asn Glu Phe Thr Ile Thr His Val Leu Ile Pro Lys Gln 
    290                 295                 300                 


Ser Ala Gly Ser Asp Tyr Cys Asn Thr Glu Asn Glu Glu Glu Leu Phe 
305                 310                 315                 320 


Leu Ile Gln Asp Gln Gln Gly Leu Ile Thr Leu Gly Trp Ile His Thr 
                325                 330                 335     


His Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His 
            340                 345                 350         


Cys Ser Tyr Gln Met Met Leu Pro Glu Ser Val Ala Ile Val Cys Ser 
        355                 360                 365             


Pro Lys Phe Gln Glu Thr Gly Phe Phe Lys Leu Thr Asp His Gly Leu 
    370                 375                 380                 


Glu Glu Ile Ser Ser Cys Arg Gln Lys Gly Phe His Pro His Ser Lys 
385                 390                 395                 400 


Asp Pro Pro Leu Phe Cys Ser Cys Ser His Val Thr Val Val Asp Arg 
                405                 410                 415     


Ala Val Thr Ile Thr Asp Leu Arg 
            420                 


<210> 97
<211> 471
<212> PRT
<213> Homo sapiens

<400> 97
Met Ala Ala Pro Glu Pro Leu Ser Pro Ala Gly Gly Ala Gly Glu Glu 
1               5                   10                  15      


Ala Pro Glu Glu Asp Glu Asp Glu Ala Glu Ala Glu Asp Pro Glu Arg 
            20                  25                  30          


Pro Asn Ala Gly Ala Gly Gly Gly Arg Ser Gly Gly Gly Gly Ser Ser 
        35                  40                  45              


Val Ser Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Cys Gly 
    50                  55                  60                  


Gly Pro Gly Gly Ala Leu Thr Arg Arg Ala Val Thr Leu Arg Val Leu 
65                  70                  75                  80  


Leu Lys Asp Ala Leu Leu Glu Pro Gly Ala Gly Val Leu Ser Ile Tyr 
                85                  90                  95      


Tyr Leu Gly Lys Lys Phe Leu Gly Asp Leu Gln Pro Asp Gly Arg Ile 
            100                 105                 110         


Met Trp Gln Glu Thr Gly Gln Thr Phe Asn Ser Pro Ser Ala Trp Ala 
        115                 120                 125             


Thr His Cys Lys Lys Leu Val Asn Pro Ala Lys Lys Ser Gly Cys Gly 
    130                 135                 140                 


Trp Ala Ser Val Lys Tyr Lys Gly Gln Lys Leu Asp Lys Tyr Lys Ala 
145                 150                 155                 160 


Thr Trp Leu Arg Leu His Gln Leu His Thr Pro Ala Thr Ala Ala Asp 
                165                 170                 175     


Glu Ser Pro Ala Ser Glu Gly Glu Glu Glu Glu Leu Leu Met Glu Glu 
            180                 185                 190         


Glu Glu Glu Asp Val Leu Ala Gly Val Ser Ala Glu Asp Lys Ser Arg 
        195                 200                 205             


Arg Pro Leu Gly Lys Ser Pro Ser Glu Pro Ala His Pro Glu Ala Thr 
    210                 215                 220                 


Thr Pro Gly Lys Arg Val Asp Ser Lys Ile Arg Val Pro Val Arg Tyr 
225                 230                 235                 240 


Cys Met Leu Gly Ser Arg Asp Leu Ala Arg Asn Pro His Thr Leu Val 
                245                 250                 255     


Glu Val Thr Ser Phe Ala Ala Ile Asn Lys Phe Gln Pro Phe Asn Val 
            260                 265                 270         


Ala Val Ser Ser Asn Val Leu Phe Leu Leu Asp Phe His Ser His Leu 
        275                 280                 285             


Thr Arg Ser Glu Val Val Gly Tyr Leu Gly Gly Arg Trp Asp Val Asn 
    290                 295                 300                 


Ser Gln Met Leu Thr Val Leu Arg Ala Phe Pro Cys Arg Ser Arg Leu 
305                 310                 315                 320 


Gly Asp Ala Glu Thr Ala Ala Ala Ile Glu Glu Glu Ile Tyr Gln Ser 
                325                 330                 335     


Leu Phe Leu Arg Gly Leu Ser Leu Val Gly Trp Tyr His Ser His Pro 
            340                 345                 350         


His Ser Pro Ala Leu Pro Ser Leu Gln Asp Ile Asp Ala Gln Met Asp 
        355                 360                 365             


Tyr Gln Leu Arg Leu Gln Gly Ser Ser Asn Gly Phe Gln Pro Cys Leu 
    370                 375                 380                 


Ala Leu Leu Cys Ser Pro Tyr Tyr Ser Gly Asn Pro Gly Pro Glu Ser 
385                 390                 395                 400 


Lys Ile Ser Pro Phe Trp Val Met Pro Pro Pro Glu Met Leu Leu Val 
                405                 410                 415     


Glu Phe Tyr Lys Gly Ser Pro Asp Leu Val Arg Leu Gln Glu Pro Trp 
            420                 425                 430         


Ser Gln Glu His Thr Tyr Leu Asp Lys Leu Lys Ile Ser Leu Ala Ser 
        435                 440                 445             


Arg Thr Pro Lys Asp Gln Ser Leu Cys His Val Leu Glu Gln Val Cys 
    450                 455                 460                 


Gly Val Leu Lys Gln Gly Ser 
465                 470     


<210> 98
<211> 208
<212> PRT
<213> Homo sapiens

<400> 98
Met Gly Glu Val Glu Ile Ser Ala Leu Ala Tyr Val Lys Met Cys Leu 
1               5                   10                  15      


His Ala Ala Arg Tyr Pro His Ala Ala Val Asn Gly Leu Phe Leu Ala 
            20                  25                  30          


Pro Ala Pro Arg Ser Gly Glu Cys Leu Cys Leu Thr Asp Cys Val Pro 
        35                  40                  45              


Leu Phe His Ser His Leu Ala Leu Ser Val Met Leu Glu Val Ala Leu 
    50                  55                  60                  


Asn Gln Val Asp Val Trp Gly Ala Gln Ala Gly Leu Val Val Ala Gly 
65                  70                  75                  80  


Tyr Tyr His Ala Asn Ala Ala Val Asn Asp Gln Ser Pro Gly Pro Leu 
                85                  90                  95      


Ala Leu Lys Ile Ala Gly Arg Ile Ala Glu Phe Phe Pro Asp Ala Val 
            100                 105                 110         


Leu Ile Met Leu Asp Asn Gln Lys Leu Val Pro Gln Pro Arg Val Pro 
        115                 120                 125             


Pro Val Ile Val Leu Glu Asn Gln Gly Leu Arg Trp Val Pro Lys Asp 
    130                 135                 140                 


Lys Asn Leu Val Met Trp Arg Asp Trp Glu Glu Ser Arg Gln Met Val 
145                 150                 155                 160 


Gly Ala Leu Leu Glu Asp Arg Ala His Gln His Leu Val Asp Phe Asp 
                165                 170                 175     


Cys His Leu Asp Asp Ile Arg Gln Asp Trp Thr Asn Gln Arg Leu Asn 
            180                 185                 190         


Thr Gln Ile Thr Gln Trp Val Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200                 205             


<210> 99
<211> 310
<212> PRT
<213> Homo sapiens

<400> 99
Met Asp Arg Leu Leu Arg Leu Gly Gly Gly Met Pro Gly Leu Gly Gln 
1               5                   10                  15      


Gly Pro Pro Thr Asp Ala Pro Ala Val Asp Thr Ala Glu Gln Val Tyr 
            20                  25                  30          


Ile Ser Ser Leu Ala Leu Leu Lys Met Leu Lys His Gly Arg Ala Gly 
        35                  40                  45              


Val Pro Met Glu Val Met Gly Leu Met Leu Gly Glu Phe Val Asp Asp 
    50                  55                  60                  


Tyr Thr Val Arg Val Ile Asp Val Phe Ala Met Pro Gln Ser Gly Thr 
65                  70                  75                  80  


Gly Val Ser Val Glu Ala Val Asp Pro Val Phe Gln Ala Lys Met Leu 
                85                  90                  95      


Asp Met Leu Lys Gln Thr Gly Arg Pro Glu Met Val Val Gly Trp Tyr 
            100                 105                 110         


His Ser His Pro Gly Phe Gly Cys Trp Leu Ser Gly Val Asp Ile Asn 
        115                 120                 125             


Thr Gln Gln Ser Phe Glu Ala Leu Ser Glu Arg Ala Val Ala Val Val 
    130                 135                 140                 


Val Asp Pro Ile Gln Ser Val Lys Gly Lys Val Val Ile Asp Ala Phe 
145                 150                 155                 160 


Arg Leu Ile Asn Ala Asn Met Met Val Leu Gly His Glu Pro Arg Gln 
                165                 170                 175     


Thr Thr Ser Asn Leu Gly His Leu Asn Lys Pro Ser Ile Gln Ala Leu 
            180                 185                 190         


Ile His Gly Leu Asn Arg His Tyr Tyr Ser Ile Thr Ile Asn Tyr Arg 
        195                 200                 205             


Lys Asn Glu Leu Glu Gln Lys Met Leu Leu Asn Leu His Lys Lys Ser 
    210                 215                 220                 


Trp Met Glu Gly Leu Thr Leu Gln Asp Tyr Ser Glu His Cys Lys His 
225                 230                 235                 240 


Asn Glu Ser Val Val Lys Glu Met Leu Glu Leu Ala Lys Asn Tyr Asn 
                245                 250                 255     


Lys Ala Val Glu Glu Glu Asp Lys Met Thr Pro Glu Gln Leu Ala Ile 
            260                 265                 270         


Lys Asn Val Gly Lys Gln Asp Pro Lys Arg His Leu Glu Glu His Val 
        275                 280                 285             


Asp Val Leu Met Thr Ser Asn Ile Val Gln Cys Leu Ala Ala Met Leu 
    290                 295                 300                 


Asp Thr Val Val Phe Lys 
305                 310 


<210> 100
<211> 828
<212> PRT
<213> Homo sapiens

<400> 100
Met Ala Ala Glu Glu Ala Asp Val Asp Ile Glu Gly Asp Val Val Ala 
1               5                   10                  15      


Ala Ala Gly Ala Gln Pro Gly Ser Gly Glu Asn Thr Ala Ser Val Leu 
            20                  25                  30          


Gln Lys Asp His Tyr Leu Asp Ser Ser Trp Arg Thr Glu Asn Gly Leu 
        35                  40                  45              


Ile Pro Trp Thr Leu Asp Asn Thr Ile Ser Glu Glu Asn Arg Ala Val 
    50                  55                  60                  


Ile Glu Lys Met Leu Leu Glu Glu Glu Tyr Tyr Leu Ser Lys Lys Ser 
65                  70                  75                  80  


Gln Pro Glu Lys Val Trp Leu Asp Gln Lys Glu Asp Asp Lys Lys Tyr 
                85                  90                  95      


Met Lys Ser Leu Gln Lys Thr Ala Lys Ile Met Val His Ser Pro Thr 
            100                 105                 110         


Lys Pro Ala Ser Tyr Ser Val Lys Trp Thr Ile Glu Glu Lys Glu Leu 
        115                 120                 125             


Phe Glu Gln Gly Leu Ala Lys Phe Gly Arg Arg Trp Thr Lys Ile Ser 
    130                 135                 140                 


Lys Leu Ile Gly Ser Arg Thr Val Leu Gln Val Lys Ser Tyr Ala Arg 
145                 150                 155                 160 


Gln Tyr Phe Lys Asn Lys Val Lys Cys Gly Leu Asp Lys Glu Thr Pro 
                165                 170                 175     


Asn Gln Lys Thr Gly His Asn Leu Gln Val Lys Asn Glu Asp Lys Gly 
            180                 185                 190         


Thr Lys Ala Trp Thr Pro Ser Cys Leu Arg Gly Arg Ala Asp Pro Asn 
        195                 200                 205             


Leu Asn Ala Val Lys Ile Glu Lys Leu Ser Asp Asp Glu Glu Val Asp 
    210                 215                 220                 


Ile Thr Asp Glu Val Asp Glu Leu Ser Ser Gln Thr Pro Gln Lys Asn 
225                 230                 235                 240 


Ser Ser Ser Asp Leu Leu Leu Asp Phe Pro Asn Ser Lys Met His Glu 
                245                 250                 255     


Thr Asn Gln Gly Glu Phe Ile Thr Ser Asp Ser Gln Glu Ala Leu Phe 
            260                 265                 270         


Ser Lys Ser Ser Arg Gly Cys Leu Gln Asn Glu Lys Gln Asp Glu Thr 
        275                 280                 285             


Leu Ser Ser Ser Glu Ile Thr Leu Trp Thr Glu Lys Gln Ser Asn Gly 
    290                 295                 300                 


Asp Lys Lys Ser Ile Glu Leu Asn Asp Gln Lys Phe Asn Glu Leu Ile 
305                 310                 315                 320 


Lys Asn Cys Asn Lys His Asp Gly Arg Gly Ile Ile Val Asp Ala Arg 
                325                 330                 335     


Gln Leu Pro Ser Pro Glu Pro Cys Glu Ile Gln Lys Asn Leu Asn Asp 
            340                 345                 350         


Asn Glu Met Leu Phe His Ser Cys Gln Met Val Glu Glu Ser His Glu 
        355                 360                 365             


Glu Glu Glu Leu Lys Pro Pro Glu Gln Glu Ile Glu Ile Asp Arg Asn 
    370                 375                 380                 


Ile Ile Gln Glu Glu Glu Lys Gln Ala Ile Pro Glu Phe Phe Glu Gly 
385                 390                 395                 400 


Arg Gln Ala Lys Thr Pro Glu Arg Tyr Leu Lys Ile Arg Asn Tyr Ile 
                405                 410                 415     


Leu Asp Gln Trp Glu Ile Cys Lys Pro Lys Tyr Leu Asn Lys Thr Ser 
            420                 425                 430         


Val Arg Pro Gly Leu Lys Asn Cys Gly Asp Val Asn Cys Ile Gly Arg 
        435                 440                 445             


Ile His Thr Tyr Leu Glu Leu Ile Gly Ala Ile Asn Phe Gly Cys Glu 
    450                 455                 460                 


Gln Ala Val Tyr Asn Arg Pro Gln Thr Val Asp Lys Val Arg Ile Arg 
465                 470                 475                 480 


Asp Arg Lys Asp Ala Val Glu Ala Tyr Gln Leu Ala Gln Arg Leu Gln 
                485                 490                 495     


Ser Met Arg Thr Arg Arg Arg Arg Val Arg Asp Pro Trp Gly Asn Trp 
            500                 505                 510         


Cys Asp Ala Lys Asp Leu Glu Gly Gln Thr Phe Glu His Leu Ser Ala 
        515                 520                 525             


Glu Glu Leu Ala Lys Arg Arg Glu Glu Glu Lys Gly Arg Pro Val Lys 
    530                 535                 540                 


Ser Leu Lys Val Pro Arg Pro Thr Lys Ser Ser Phe Asp Pro Phe Gln 
545                 550                 555                 560 


Leu Ile Pro Cys Asn Phe Phe Ser Glu Glu Lys Gln Glu Pro Phe Gln 
                565                 570                 575     


Val Lys Val Ala Ser Glu Ala Leu Leu Ile Met Asp Leu His Ala His 
            580                 585                 590         


Val Ser Met Ala Glu Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser Glu 
        595                 600                 605             


Val Asp Lys Val Val Glu Val Cys Ala Ala Glu Pro Cys Asn Ser Leu 
    610                 615                 620                 


Ser Thr Gly Leu Gln Cys Glu Met Asp Pro Val Ser Gln Thr Gln Ala 
625                 630                 635                 640 


Ser Glu Thr Leu Ala Val Arg Gly Phe Ser Val Ile Gly Trp Tyr His 
                645                 650                 655     


Ser His Pro Ala Phe Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp Thr 
            660                 665                 670         


Gln Ala Lys Tyr Gln Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe Ile 
        675                 680                 685             


Gly Met Ile Val Ser Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr Ser 
    690                 695                 700                 


Gln Ile Thr Cys Leu Val Ile Ser Glu Glu Ile Ser Pro Asp Gly Ser 
705                 710                 715                 720 


Tyr Arg Leu Pro Tyr Lys Phe Glu Val Gln Gln Met Leu Glu Glu Pro 
                725                 730                 735     


Gln Trp Gly Leu Val Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys Tyr 
            740                 745                 750         


Arg Leu Ser His Ser Ser Val Pro Met Asp Lys Ile Phe Arg Arg Asp 
        755                 760                 765             


Ser Asp Leu Thr Cys Leu Gln Lys Leu Leu Glu Cys Met Arg Lys Thr 
    770                 775                 780                 


Leu Ser Lys Val Thr Asn Cys Phe Met Ala Glu Glu Phe Leu Thr Glu 
785                 790                 795                 800 


Ile Glu Asn Leu Phe Leu Ser Asn Tyr Lys Ser Asn Gln Glu Asn Gly 
                805                 810                 815     


Val Thr Glu Glu Asn Cys Thr Lys Glu Leu Leu Met 
            820                 825             


<210> 101
<211> 415
<212> PRT
<213> Homo sapiens

<400> 101
Met Ala Ala Ser Ile Ser Gly Tyr Thr Phe Ser Ala Val Cys Phe His 
1               5                   10                  15      


Ser Ala Asn Ser Asn Ala Asp His Glu Gly Phe Leu Leu Gly Glu Val 
            20                  25                  30          


Arg Gln Glu Glu Thr Phe Ser Ile Ser Asp Ser Gln Ile Ser Asn Thr 
        35                  40                  45              


Glu Phe Leu Gln Val Ile Glu Ile His Asn His Gln Pro Cys Ser Lys 
    50                  55                  60                  


Leu Phe Ser Phe Tyr Asp Tyr Ala Ser Lys Val Asn Glu Glu Ser Leu 
65                  70                  75                  80  


Asp Arg Ile Leu Lys Asp Arg Arg Lys Lys Val Ile Gly Trp Tyr Arg 
                85                  90                  95      


Phe Arg Arg Asn Thr Gln Gln Gln Met Ser Tyr Arg Glu Gln Val Leu 
            100                 105                 110         


His Lys Gln Leu Thr Arg Ile Leu Gly Val Pro Asp Leu Val Phe Leu 
        115                 120                 125             


Leu Phe Ser Phe Ile Ser Thr Ala Asn Asn Ser Thr His Ala Leu Glu 
    130                 135                 140                 


Tyr Val Leu Phe Arg Pro Asn Arg Arg Tyr Asn Gln Arg Ile Ser Leu 
145                 150                 155                 160 


Ala Ile Pro Asn Leu Gly Asn Thr Ser Gln Gln Glu Tyr Lys Val Ser 
                165                 170                 175     


Ser Val Pro Asn Thr Ser Gln Ser Tyr Ala Lys Val Ile Lys Glu His 
            180                 185                 190         


Gly Thr Asp Phe Phe Asp Lys Asp Gly Val Met Lys Asp Ile Arg Ala 
        195                 200                 205             


Ile Tyr Gln Val Tyr Asn Ala Leu Gln Glu Lys Val Gln Ala Val Cys 
    210                 215                 220                 


Ala Asp Val Glu Lys Ser Glu Arg Val Val Glu Ser Cys Gln Ala Glu 
225                 230                 235                 240 


Val Asn Lys Leu Arg Arg Gln Ile Thr Gln Arg Lys Asn Glu Lys Glu 
                245                 250                 255     


Gln Glu Arg Arg Leu Gln Gln Ala Val Leu Ser Arg Gln Met Pro Ser 
            260                 265                 270         


Glu Ser Leu Asp Pro Ala Phe Ser Pro Arg Met Pro Ser Ser Gly Phe 
        275                 280                 285             


Ala Ala Glu Gly Arg Ser Thr Leu Gly Asp Ala Glu Ala Ser Asp Pro 
    290                 295                 300                 


Pro Pro Pro Tyr Ser Asp Phe His Pro Asn Asn Gln Glu Ser Thr Leu 
305                 310                 315                 320 


Ser His Ser Arg Met Glu Arg Ser Val Phe Met Pro Arg Pro Gln Ala 
                325                 330                 335     


Val Gly Ser Ser Asn Tyr Ala Ser Thr Ser Ala Gly Leu Lys Tyr Pro 
            340                 345                 350         


Gly Ser Gly Ala Asp Leu Pro Pro Pro Gln Arg Ala Ala Gly Asp Ser 
        355                 360                 365             


Gly Glu Asp Ser Asp Asp Ser Asp Tyr Glu Asn Leu Ile Asp Pro Thr 
    370                 375                 380                 


Glu Pro Ser Asn Ser Glu Tyr Ser His Ser Lys Asp Ser Arg Pro Met 
385                 390                 395                 400 


Ala His Pro Asp Glu Asp Pro Arg Asn Thr Gln Thr Ser Gln Ile 
                405                 410                 415 


<210> 102
<211> 2335
<212> PRT
<213> Homo sapiens

<400> 102
Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210> 103
<211> 608
<212> PRT
<213> Homo sapiens

<400> 103
Met Ala Glu Ser Ile Ile Ile Arg Val Gln Ser Pro Asp Gly Val Lys 
1               5                   10                  15      


Arg Ile Thr Ala Thr Lys Arg Glu Thr Ala Ala Thr Phe Leu Lys Lys 
            20                  25                  30          


Val Ala Lys Glu Phe Gly Phe Gln Asn Asn Gly Phe Ser Val Tyr Ile 
        35                  40                  45              


Asn Arg Asn Lys Thr Gly Glu Ile Thr Ala Ser Ser Asn Lys Ser Leu 
    50                  55                  60                  


Asn Leu Leu Lys Ile Lys His Gly Asp Leu Leu Phe Leu Phe Pro Ser 
65                  70                  75                  80  


Ser Leu Ala Gly Pro Ser Ser Glu Met Glu Thr Ser Val Pro Pro Gly 
                85                  90                  95      


Phe Lys Val Phe Gly Ala Pro Asn Val Val Glu Asp Glu Ile Asp Gln 
            100                 105                 110         


Tyr Leu Ser Lys Gln Asp Gly Lys Ile Tyr Arg Ser Arg Asp Pro Gln 
        115                 120                 125             


Leu Cys Arg His Gly Pro Leu Gly Lys Cys Val His Cys Val Pro Leu 
    130                 135                 140                 


Glu Pro Phe Asp Glu Asp Tyr Leu Asn His Leu Glu Pro Pro Val Lys 
145                 150                 155                 160 


His Met Ser Phe His Ala Tyr Ile Arg Lys Leu Thr Gly Gly Ala Asp 
                165                 170                 175     


Lys Gly Lys Phe Val Ala Leu Glu Asn Ile Ser Cys Lys Ile Lys Ser 
            180                 185                 190         


Gly Cys Glu Gly His Leu Pro Trp Pro Asn Gly Ile Cys Thr Lys Cys 
        195                 200                 205             


Gln Pro Ser Ala Ile Thr Leu Asn Arg Gln Lys Tyr Arg His Val Asp 
    210                 215                 220                 


Asn Ile Met Phe Glu Asn His Thr Val Ala Asp Arg Phe Leu Asp Phe 
225                 230                 235                 240 


Trp Arg Lys Thr Gly Asn Gln His Phe Gly Tyr Leu Tyr Gly Arg Tyr 
                245                 250                 255     


Thr Glu His Lys Asp Ile Pro Leu Gly Ile Arg Ala Glu Val Ala Ala 
            260                 265                 270         


Ile Tyr Glu Pro Pro Gln Ile Gly Thr Gln Asn Ser Leu Glu Leu Leu 
        275                 280                 285             


Glu Asp Pro Lys Ala Glu Val Val Asp Glu Ile Ala Ala Lys Leu Gly 
    290                 295                 300                 


Leu Arg Lys Val Gly Trp Ile Phe Thr Asp Leu Val Ser Glu Asp Thr 
305                 310                 315                 320 


Arg Lys Gly Thr Val Arg Tyr Ser Arg Asn Lys Asp Thr Tyr Phe Leu 
                325                 330                 335     


Ser Ser Glu Glu Cys Ile Thr Ala Gly Asp Phe Gln Asn Lys His Pro 
            340                 345                 350         


Asn Met Cys Arg Leu Ser Pro Asp Gly His Phe Gly Ser Lys Phe Val 
        355                 360                 365             


Thr Ala Val Ala Thr Gly Gly Pro Asp Asn Gln Val His Phe Glu Gly 
    370                 375                 380                 


Tyr Gln Val Ser Asn Gln Cys Met Ala Leu Val Arg Asp Glu Cys Leu 
385                 390                 395                 400 


Leu Pro Cys Lys Asp Ala Pro Glu Leu Gly Tyr Ala Lys Glu Ser Ser 
                405                 410                 415     


Ser Glu Gln Tyr Val Pro Asp Val Phe Tyr Lys Asp Val Asp Lys Phe 
            420                 425                 430         


Gly Asn Glu Ile Thr Gln Leu Ala Arg Pro Leu Pro Val Glu Tyr Leu 
        435                 440                 445             


Ile Ile Asp Ile Thr Thr Thr Phe Pro Lys Asp Pro Val Tyr Thr Phe 
    450                 455                 460                 


Ser Ile Ser Gln Asn Pro Phe Pro Ile Glu Asn Arg Asp Val Leu Gly 
465                 470                 475                 480 


Glu Thr Gln Asp Phe His Ser Leu Ala Thr Tyr Leu Ser Gln Asn Thr 
                485                 490                 495     


Ser Ser Val Phe Leu Asp Thr Ile Ser Asp Phe His Leu Leu Leu Phe 
            500                 505                 510         


Leu Val Thr Asn Glu Val Met Pro Leu Gln Asp Ser Ile Ser Leu Leu 
        515                 520                 525             


Leu Glu Ala Val Arg Thr Arg Asn Glu Glu Leu Ala Gln Thr Trp Lys 
    530                 535                 540                 


Arg Ser Glu Gln Trp Ala Thr Ile Glu Gln Leu Cys Ser Thr Val Gly 
545                 550                 555                 560 


Gly Gln Leu Pro Gly Leu His Glu Tyr Gly Ala Val Gly Gly Ser Thr 
                565                 570                 575     


His Thr Ala Thr Ala Ala Met Trp Ala Cys Gln His Cys Thr Phe Met 
            580                 585                 590         


Asn Gln Pro Gly Thr Gly His Cys Glu Met Cys Ser Leu Pro Arg Thr 
        595                 600                 605             


<210> 104
<211> 210
<212> PRT
<213> Homo sapiens

<400> 104
Met Pro Gly Val Lys Leu Thr Thr Gln Ala Tyr Cys Lys Met Val Leu 
1               5                   10                  15      


His Gly Ala Lys Tyr Pro His Cys Ala Val Asn Gly Leu Leu Val Ala 
            20                  25                  30          


Glu Lys Gln Lys Pro Arg Lys Glu His Leu Pro Leu Gly Gly Pro Gly 
        35                  40                  45              


Ala His His Thr Leu Phe Val Asp Cys Ile Pro Leu Phe His Gly Thr 
    50                  55                  60                  


Leu Ala Leu Ala Pro Met Leu Glu Val Ala Leu Thr Leu Ile Asp Ser 
65                  70                  75                  80  


Trp Cys Lys Asp His Ser Tyr Val Ile Ala Gly Tyr Tyr Gln Ala Asn 
                85                  90                  95      


Glu Arg Val Lys Asp Ala Ser Pro Asn Gln Val Ala Glu Lys Val Ala 
            100                 105                 110         


Ser Arg Ile Ala Glu Gly Phe Ser Asp Thr Ala Leu Ile Met Val Asp 
        115                 120                 125             


Asn Thr Lys Phe Thr Met Asp Cys Val Ala Pro Thr Ile His Val Tyr 
    130                 135                 140                 


Glu His His Glu Asn Arg Trp Arg Cys Arg Asp Pro His His Asp Tyr 
145                 150                 155                 160 


Cys Glu Asp Trp Pro Glu Ala Gln Arg Ile Ser Ala Ser Leu Leu Asp 
                165                 170                 175     


Ser Arg Ser Tyr Glu Thr Leu Val Asp Phe Asp Asn His Leu Asp Asp 
            180                 185                 190         


Ile Arg Asn Asp Trp Thr Asn Pro Glu Ile Asn Lys Ala Val Leu His 
        195                 200                 205             


Leu Cys 
    210 


<210> 105
<211> 409
<212> PRT
<213> Homo sapiens

<400> 105
Met Glu Gly Glu Ser Thr Ser Ala Val Leu Ser Gly Phe Val Leu Gly 
1               5                   10                  15      


Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser Asp Thr Glu Gly Phe 
            20                  25                  30          


Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn Ser Ile Thr Asp Ser 
        35                  40                  45              


Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile Asp Ile Gln Lys Tyr 
    50                  55                  60                  


Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn Ser Ser Gly Glu Val 
65                  70                  75                  80  


Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn Val Lys Lys Asn Val 
                85                  90                  95      


Val Gly Trp Tyr Lys Phe Arg Arg His Ser Asp Gln Ile Met Thr Phe 
            100                 105                 110         


Arg Glu Arg Leu Leu His Lys Asn Leu Gln Glu His Phe Ser Asn Gln 
        115                 120                 125             


Asp Leu Val Phe Leu Leu Leu Thr Pro Ser Ile Ile Thr Glu Ser Cys 
    130                 135                 140                 


Ser Thr His Arg Leu Glu His Ser Leu Tyr Lys Pro Gln Lys Gly Leu 
145                 150                 155                 160 


Phe His Arg Val Pro Leu Val Val Ala Asn Leu Gly Met Ser Glu Gln 
                165                 170                 175     


Leu Gly Tyr Lys Thr Val Ser Gly Ser Cys Met Ser Thr Gly Phe Ser 
            180                 185                 190         


Arg Ala Val Gln Thr His Ser Ser Lys Phe Phe Glu Glu Asp Gly Ser 
        195                 200                 205             


Leu Lys Glu Val His Lys Ile Asn Glu Met Tyr Ala Ser Leu Gln Glu 
    210                 215                 220                 


Glu Leu Lys Ser Ile Cys Lys Lys Val Glu Asp Ser Glu Gln Ala Val 
225                 230                 235                 240 


Asp Lys Leu Val Lys Asp Val Asn Arg Leu Lys Arg Glu Ile Glu Lys 
                245                 250                 255     


Arg Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu Lys Asn Ile Gln Lys 
            260                 265                 270         


Asp Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala Leu Arg Thr Phe Phe 
        275                 280                 285             


Pro Asn Ser Glu Phe Leu His Ser Cys Val Met Ser Leu Lys Asn Arg 
    290                 295                 300                 


His Val Ser Lys Ser Ser Cys Asn Tyr Asn His His Leu Asp Val Val 
305                 310                 315                 320 


Asp Asn Leu Thr Leu Met Val Glu His Thr Asp Ile Pro Glu Ala Ser 
                325                 330                 335     


Pro Ala Ser Thr Pro Gln Ile Ile Lys His Lys Ala Leu Asp Leu Asp 
            340                 345                 350         


Asp Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu Asp Thr Gln Asp Lys 
        355                 360                 365             


Arg Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln Asp Lys Ala Ser Lys 
    370                 375                 380                 


Met Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu Lys Met Lys Gly Phe 
385                 390                 395                 400 


Gly Glu Tyr Ser Arg Ser Pro Thr Phe 
                405                 


<210> 106
<211> 436
<212> PRT
<213> Homo sapiens

<400> 106
Met Asp Gln Pro Phe Thr Val Asn Ser Leu Lys Lys Leu Ala Ala Met 
1               5                   10                  15      


Pro Asp His Thr Asp Val Ser Leu Ser Pro Glu Glu Arg Val Arg Ala 
            20                  25                  30          


Leu Ser Lys Leu Gly Cys Asn Ile Thr Ile Ser Glu Asp Ile Thr Pro 
        35                  40                  45              


Arg Arg Tyr Phe Arg Ser Gly Val Glu Met Glu Arg Met Ala Ser Val 
    50                  55                  60                  


Tyr Leu Glu Glu Gly Asn Leu Glu Asn Ala Phe Val Leu Tyr Asn Lys 
65                  70                  75                  80  


Phe Ile Thr Leu Phe Val Glu Lys Leu Pro Asn His Arg Asp Tyr Gln 
                85                  90                  95      


Gln Cys Ala Val Pro Glu Lys Gln Asp Ile Met Lys Lys Leu Lys Glu 
            100                 105                 110         


Ile Ala Phe Pro Arg Thr Asp Glu Leu Lys Asn Asp Leu Leu Lys Lys 
        115                 120                 125             


Tyr Asn Val Glu Tyr Gln Glu Tyr Leu Gln Ser Lys Asn Lys Tyr Lys 
    130                 135                 140                 


Ala Glu Ile Leu Lys Lys Leu Glu His Gln Arg Leu Ile Glu Ala Glu 
145                 150                 155                 160 


Arg Lys Arg Ile Ala Gln Met Arg Gln Gln Gln Leu Glu Ser Glu Gln 
                165                 170                 175     


Phe Leu Phe Phe Glu Asp Gln Leu Lys Lys Gln Glu Leu Ala Arg Gly 
            180                 185                 190         


Gln Met Arg Ser Gln Gln Thr Ser Gly Leu Ser Glu Gln Ile Asp Gly 
        195                 200                 205             


Ser Ala Leu Ser Cys Phe Ser Thr His Gln Asn Asn Ser Leu Leu Asn 
    210                 215                 220                 


Val Phe Ala Asp Gln Pro Asn Lys Ser Asp Ala Thr Asn Tyr Ala Ser 
225                 230                 235                 240 


His Ser Pro Pro Val Asn Arg Ala Leu Thr Pro Ala Ala Thr Leu Ser 
                245                 250                 255     


Ala Val Gln Asn Leu Val Val Glu Gly Leu Arg Cys Val Val Leu Pro 
            260                 265                 270         


Glu Asp Leu Cys His Lys Phe Leu Gln Leu Ala Glu Ser Asn Thr Val 
        275                 280                 285             


Arg Gly Ile Glu Thr Cys Gly Ile Leu Cys Gly Lys Leu Thr His Asn 
    290                 295                 300                 


Glu Phe Thr Ile Thr His Val Ile Val Pro Lys Gln Ser Ala Gly Pro 
305                 310                 315                 320 


Asp Tyr Cys Asp Met Glu Asn Val Glu Glu Leu Phe Asn Val Gln Asp 
                325                 330                 335     


Gln His Asp Leu Leu Thr Leu Gly Trp Ile His Thr His Pro Thr Gln 
            340                 345                 350         


Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His Cys Ser Tyr Gln 
        355                 360                 365             


Leu Met Leu Pro Glu Ala Ile Ala Ile Val Cys Ser Pro Lys His Lys 
    370                 375                 380                 


Asp Thr Gly Ile Phe Arg Leu Thr Asn Ala Gly Met Leu Glu Val Ser 
385                 390                 395                 400 


Ala Cys Lys Lys Lys Gly Phe His Pro His Thr Lys Glu Pro Arg Leu 
                405                 410                 415     


Phe Ser Ile Cys Lys His Val Leu Val Lys Asp Ile Lys Ile Ile Val 
            420                 425                 430         


Leu Asp Leu Arg 
        435     


<210> 107
<211> 327
<212> PRT
<213> Homo sapiens

<400> 107
Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His 
145                 150                 155                 160 


Thr Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala 
        195                 200                 205             


Thr Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr 
            260                 265                 270         


Asp Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210> 108
<211> 357
<212> PRT
<213> Homo sapiens

<400> 108
Met Ala Thr Pro Ala Val Pro Val Ser Ala Pro Pro Ala Thr Pro Thr 
1               5                   10                  15      


Pro Val Pro Ala Ala Ala Pro Ala Ser Val Pro Ala Pro Thr Pro Ala 
            20                  25                  30          


Pro Ala Ala Ala Pro Val Pro Ala Ala Ala Pro Ala Ser Ser Ser Asp 
        35                  40                  45              


Pro Ala Ala Ala Ala Ala Ala Thr Ala Ala Pro Gly Gln Thr Pro Ala 
    50                  55                  60                  


Ser Ala Gln Ala Pro Ala Gln Thr Pro Ala Pro Ala Leu Pro Gly Pro 
65                  70                  75                  80  


Ala Leu Pro Gly Pro Phe Pro Gly Gly Arg Val Val Arg Leu His Pro 
                85                  90                  95      


Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu Arg Arg Asn Glu Gly 
            100                 105                 110         


Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr Val Asp Lys His Ser 
        115                 120                 125             


Val Glu Val Thr Asn Cys Phe Ser Val Pro His Asn Glu Ser Glu Asp 
    130                 135                 140                 


Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn Met Tyr Glu Leu His 
145                 150                 155                 160 


Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly Trp Tyr Ala Thr Gly 
                165                 170                 175     


His Asp Ile Thr Glu His Ser Val Leu Ile His Glu Tyr Tyr Ser Arg 
            180                 185                 190         


Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp Thr Ser Leu Gln Asn 
        195                 200                 205             


Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr Leu Met Gly Val Pro 
    210                 215                 220                 


Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu Thr Val Lys Tyr Ala 
225                 230                 235                 240 


Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu Ile Met Lys Thr Cys 
                245                 250                 255     


Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser Asp Leu Gln Gln Val 
            260                 265                 270         


Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu Ser Thr Val Leu Gln 
        275                 280                 285             


Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser Ala Asp Asn Thr Val 
    290                 295                 300                 


Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val Pro Lys Ile Val Pro 
305                 310                 315                 320 


Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile Asn Asp Leu Leu Met 
                325                 330                 335     


Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln Ile Ala Leu Asn Glu 
            340                 345                 350         


Lys Leu Val Asn Leu 
        355         


<210> 109
<211> 324
<212> PRT
<213> Homo sapiens

<400> 109
Met Pro Glu Leu Ala Val Gln Lys Val Val Val His Pro Leu Val Leu 
1               5                   10                  15      


Leu Ser Val Val Asp His Phe Asn Arg Ile Gly Lys Val Gly Asn Gln 
            20                  25                  30          


Lys Arg Val Val Gly Val Leu Leu Gly Ser Trp Gln Lys Lys Val Leu 
        35                  40                  45              


Asp Val Ser Asn Ser Phe Ala Val Pro Phe Asp Glu Asp Asp Lys Asp 
    50                  55                  60                  


Asp Ser Val Trp Phe Leu Asp His Asp Tyr Leu Glu Asn Met Tyr Gly 
65                  70                  75                  80  


Met Phe Lys Lys Val Asn Ala Arg Glu Arg Ile Val Gly Trp Tyr His 
                85                  90                  95      


Thr Gly Pro Lys Leu His Lys Asn Asp Ile Ala Ile Asn Glu Leu Met 
            100                 105                 110         


Lys Arg Tyr Cys Pro Asn Ser Val Leu Val Ile Ile Asp Val Lys Pro 
        115                 120                 125             


Lys Asp Leu Gly Leu Pro Thr Glu Ala Tyr Ile Ser Val Glu Glu Val 
    130                 135                 140                 


His Asp Asp Gly Thr Pro Thr Ser Lys Thr Phe Glu His Val Thr Ser 
145                 150                 155                 160 


Glu Ile Gly Ala Glu Glu Ala Glu Glu Val Gly Val Glu His Leu Leu 
                165                 170                 175     


Arg Asp Ile Lys Asp Thr Thr Val Gly Thr Leu Ser Gln Arg Ile Thr 
            180                 185                 190         


Asn Gln Val His Gly Leu Lys Gly Leu Asn Ser Lys Leu Leu Asp Ile 
        195                 200                 205             


Arg Ser Tyr Leu Glu Lys Val Ala Thr Gly Lys Leu Pro Ile Asn His 
    210                 215                 220                 


Gln Ile Ile Tyr Gln Leu Gln Asp Val Phe Asn Leu Leu Pro Asp Val 
225                 230                 235                 240 


Ser Leu Gln Glu Phe Val Lys Ala Phe Tyr Leu Lys Thr Asn Asp Gln 
                245                 250                 255     


Met Val Val Val Tyr Leu Ala Ser Leu Ile Arg Ser Val Val Ala Leu 
            260                 265                 270         


His Asn Leu Ile Asn Asn Lys Ile Ala Asn Arg Asp Ala Glu Lys Lys 
        275                 280                 285             


Glu Gly Gln Glu Lys Glu Glu Ser Lys Lys Asp Arg Lys Glu Asp Lys 
    290                 295                 300                 


Glu Lys Asp Lys Asp Lys Glu Lys Ser Asp Val Lys Lys Glu Glu Lys 
305                 310                 315                 320 


Lys Glu Lys Lys 
                


<210> 110
<211> 352
<212> PRT
<213> Homo sapiens

<400> 110
Met Ala Ser Arg Lys Glu Gly Thr Gly Ser Thr Ala Thr Ser Ser Ser 
1               5                   10                  15      


Ser Thr Ala Gly Ala Ala Gly Lys Gly Lys Gly Lys Gly Gly Ser Gly 
            20                  25                  30          


Asp Ser Ala Val Lys Gln Val Gln Ile Asp Gly Leu Val Val Leu Lys 
        35                  40                  45              


Ile Ile Lys His Tyr Gln Glu Glu Gly Gln Gly Thr Glu Val Val Gln 
    50                  55                  60                  


Gly Val Leu Leu Gly Leu Val Val Glu Asp Arg Leu Glu Ile Thr Asn 
65                  70                  75                  80  


Cys Phe Pro Phe Pro Gln His Thr Glu Asp Asp Ala Asp Phe Asp Glu 
                85                  90                  95      


Val Gln Tyr Gln Met Glu Met Met Arg Ser Leu Arg His Val Asn Ile 
            100                 105                 110         


Asp His Leu His Val Gly Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe 
        115                 120                 125             


Val Thr Arg Ala Leu Leu Asp Ser Gln Phe Ser Tyr Gln His Ala Ile 
    130                 135                 140                 


Glu Glu Ser Val Val Leu Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly 
145                 150                 155                 160 


Ser Leu Ser Leu Lys Ala Tyr Arg Leu Thr Pro Lys Leu Met Glu Val 
                165                 170                 175     


Cys Lys Glu Lys Asp Phe Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile 
            180                 185                 190         


Thr Phe Glu Tyr Met Phe Glu Glu Val Pro Ile Val Ile Lys Asn Ser 
        195                 200                 205             


His Leu Ile Asn Val Leu Met Trp Glu Leu Glu Lys Lys Ser Ala Val 
    210                 215                 220                 


Ala Asp Lys His Glu Leu Leu Ser Leu Ala Ser Ser Asn His Leu Gly 
225                 230                 235                 240 


Lys Asn Leu Gln Leu Leu Met Asp Arg Val Asp Glu Met Ser Gln Asp 
                245                 250                 255     


Ile Val Lys Tyr Asn Thr Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln 
            260                 265                 270         


Gln Lys His Gln Tyr Gln Gln Arg Arg Gln Gln Glu Asn Met Gln Arg 
        275                 280                 285             


Gln Ser Arg Gly Glu Pro Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu 
    290                 295                 300                 


Phe Lys Pro Pro Gln Pro Pro Ala Arg Met Asp Ser Leu Leu Ile Ala 
305                 310                 315                 320 


Gly Gln Ile Asn Thr Tyr Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln 
                325                 330                 335     


Asn Leu Gly Lys Leu Phe Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn 
            340                 345                 350         


<210> 111
<211> 334
<212> PRT
<213> Homo sapiens

<400> 111
Met Ala Ala Ser Gly Ser Gly Met Ala Gln Lys Thr Trp Glu Leu Ala 
1               5                   10                  15      


Asn Asn Met Gln Glu Ala Gln Ser Ile Asp Glu Ile Tyr Lys Tyr Asp 
            20                  25                  30          


Lys Lys Gln Gln Gln Glu Ile Leu Ala Ala Lys Pro Trp Thr Lys Asp 
        35                  40                  45              


His His Tyr Phe Lys Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys 
    50                  55                  60                  


Met Val Met His Ala Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu 
65                  70                  75                  80  


Met Leu Gly Lys Val Asp Gly Glu Thr Met Ile Ile Met Asp Ser Phe 
                85                  90                  95      


Ala Leu Pro Val Glu Gly Thr Glu Thr Arg Val Asn Ala Gln Ala Ala 
            100                 105                 110         


Ala Tyr Glu Tyr Met Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly 
        115                 120                 125             


Arg Leu Glu Asn Ala Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly 
    130                 135                 140                 


Cys Trp Leu Ser Gly Ile Asp Val Ser Thr Gln Met Leu Asn Gln Gln 
145                 150                 155                 160 


Phe Gln Glu Pro Phe Val Ala Val Val Ile Asp Pro Thr Arg Thr Ile 
                165                 170                 175     


Ser Ala Gly Lys Val Asn Leu Gly Ala Phe Arg Thr Tyr Pro Lys Gly 
            180                 185                 190         


Tyr Lys Pro Pro Asp Glu Gly Pro Ser Glu Tyr Gln Thr Ile Pro Leu 
        195                 200                 205             


Asn Lys Ile Glu Asp Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu 
    210                 215                 220                 


Glu Val Ser Tyr Phe Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu 
225                 230                 235                 240 


Leu Trp Asn Lys Tyr Trp Val Asn Thr Leu Ser Ser Ser Ser Leu Leu 
                245                 250                 255     


Thr Asn Ala Asp Tyr Thr Thr Gly Gln Val Phe Asp Leu Ser Glu Lys 
            260                 265                 270         


Leu Glu Gln Ser Glu Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly 
        275                 280                 285             


Leu Glu Thr His Asp Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Thr 
    290                 295                 300                 


Arg Asp Ser Cys Lys Thr Thr Ile Glu Ala Ile His Gly Leu Met Ser 
305                 310                 315                 320 


Gln Val Ile Lys Asp Lys Leu Phe Asn Gln Ile Asn Ile Ser 
                325                 330                 


<210> 112
<211> 316
<212> PRT
<213> Homo sapiens

<400> 112
Met Ala Val Gln Val Val Gln Ala Val Gln Ala Val His Leu Glu Ser 
1               5                   10                  15      


Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu Ser Thr Glu Lys Glu 
            20                  25                  30          


Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn Asp Asp Thr Arg Ser 
        35                  40                  45              


Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met Arg Thr Val Ala Glu 
    50                  55                  60                  


Lys Val Asp Ala Val Arg Ile Val His Ile His Ser Val Ile Ile Leu 
65                  70                  75                  80  


Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu Ile Ser Pro Glu Gln 
                85                  90                  95      


Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu Ala Glu Leu Thr Gly 
            100                 105                 110         


Arg Pro Met Arg Val Val Gly Trp Tyr His Ser His Pro His Ile Thr 
        115                 120                 125             


Val Trp Pro Ser His Val Asp Val Arg Thr Gln Ala Met Tyr Gln Met 
    130                 135                 140                 


Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser Cys Phe Ile Glu Asp 
145                 150                 155                 160 


Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr Cys Phe Gln Ser Ile 
                165                 170                 175     


Gln Ala Gln Lys Ser Ser Glu Ser Leu His Gly Pro Arg Asp Phe Trp 
            180                 185                 190         


Ser Ser Ser Gln His Ile Ser Ile Glu Gly Gln Lys Glu Glu Glu Arg 
        195                 200                 205             


Tyr Glu Arg Ile Glu Ile Pro Ile His Ile Val Pro His Val Thr Ile 
    210                 215                 220                 


Gly Lys Val Cys Leu Glu Ser Ala Val Glu Leu Pro Lys Ile Leu Cys 
225                 230                 235                 240 


Gln Glu Glu Gln Asp Ala Tyr Arg Arg Ile His Ser Leu Thr His Leu 
                245                 250                 255     


Asp Ser Val Thr Lys Ile His Asn Gly Ser Val Phe Thr Lys Asn Leu 
            260                 265                 270         


Cys Ser Gln Met Ser Ala Val Ser Gly Pro Leu Leu Gln Trp Leu Glu 
        275                 280                 285             


Asp Arg Leu Glu Gln Asn Gln Gln His Leu Gln Glu Leu Gln Gln Glu 
    290                 295                 300                 


Lys Glu Glu Leu Met Gln Glu Leu Ser Ser Leu Glu 
305                 310                 315     


<210> 113
<211> 368
<212> PRT
<213> Homo sapiens

<400> 113
Ser Ser Phe Thr Ile Gly Leu Arg Gly Leu Ile Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His Thr Pro Ile Leu 
            20                  25                  30          


Arg Asp Phe Phe Leu Ser Asp Arg His Arg Cys Glu Met Pro Ser Pro 
        35                  40                  45              


Glu Leu Cys Leu Val Cys Glu Met Ser Ser Leu Phe Arg Glu Leu Tyr 
    50                  55                  60                  


Ser Gly Asn Pro Ser Pro His Val Pro Tyr Lys Leu Leu His Leu Val 
65                  70                  75                  80  


Trp Ile His Ala Arg His Leu Ala Gly Tyr Arg Gln Gln Asp Ala His 
                85                  90                  95      


Glu Phe Leu Ile Ala Ala Leu Asp Val Leu His Arg His Cys Lys Gly 
            100                 105                 110         


Asp Asp Val Gly Lys Ala Ala Asn Asn Pro Asn His Cys Asn Cys Ile 
        115                 120                 125             


Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val Thr Cys Gln 
    130                 135                 140                 


Ala Cys His Gly Val Ser Thr Thr Ile Asp Pro Cys Trp Asp Ile Ser 
145                 150                 155                 160 


Leu Asp Leu Pro Gly Ser Cys Thr Ser Phe Trp Pro Met Ser Pro Gly 
                165                 170                 175     


Arg Glu Ser Ser Val Asn Gly Glu Ser His Ile Pro Gly Ile Thr Thr 
            180                 185                 190         


Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg Pro Glu His Leu Gly Ser 
        195                 200                 205             


Ser Ala Lys Ile Lys Cys Gly Ser Cys Gln Ser Tyr Gln Glu Ser Thr 
    210                 215                 220                 


Lys Gln Leu Thr Met Asn Lys Leu Pro Val Val Ala Cys Phe His Phe 
225                 230                 235                 240 


Lys Arg Phe Glu His Ser Ala Lys Gln Arg Arg Lys Ile Thr Thr Tyr 
                245                 250                 255     


Ile Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe Met Ala Ser Ser 
            260                 265                 270         


Lys Glu Ser Arg Met Asn Gly Gln Leu Gln Leu Pro Thr Asn Ser Gly 
        275                 280                 285             


Asn Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val Val Asn His Gln Gly 
    290                 295                 300                 


Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile Arg His His Lys Asp 
305                 310                 315                 320 


Gln Trp Phe Lys Cys Asp Asp Ala Val Ile Thr Lys Ala Ser Ile Lys 
                325                 330                 335     


Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu Phe Tyr His Lys Gln Val 
            340                 345                 350         


Leu Glu His Glu Ser Glu Lys Val Lys Glu Met Asn Thr Gln Ala Tyr 
        355                 360                 365             


<210> 114
<211> 353
<212> PRT
<213> Homo sapiens

<400> 114
Asn Ser Phe His Asn Ile Asp Asp Pro Asn Cys Glu Arg Arg Lys Lys 
1               5                   10                  15      


Asn Ser Phe Val Gly Leu Thr Asn Leu Gly Ala Thr Cys Tyr Val Asn 
            20                  25                  30          


Thr Phe Leu Gln Val Trp Phe Leu Asn Leu Glu Leu Arg Gln Ala Leu 
        35                  40                  45              


Tyr Leu Cys Pro Ser Thr Cys Ser Asp Tyr Met Leu Gly Asp Gly Ile 
    50                  55                  60                  


Gln Glu Glu Lys Asp Tyr Glu Pro Gln Thr Ile Cys Glu His Leu Gln 
65                  70                  75                  80  


Tyr Leu Phe Ala Leu Leu Gln Asn Ser Asn Arg Arg Tyr Ile Asp Pro 
                85                  90                  95      


Ser Gly Phe Val Lys Ala Leu Gly Leu Asp Thr Gly Gln Gln Gln Asp 
            100                 105                 110         


Ala Gln Glu Phe Ser Lys Leu Phe Met Ser Leu Leu Glu Asp Thr Leu 
        115                 120                 125             


Ser Lys Gln Lys Asn Pro Asp Val Arg Asn Ile Val Gln Gln Gln Phe 
    130                 135                 140                 


Cys Gly Glu Tyr Ala Tyr Val Thr Val Cys Asn Gln Cys Gly Arg Glu 
145                 150                 155                 160 


Ser Lys Leu Leu Ser Lys Phe Tyr Glu Leu Glu Leu Asn Ile Gln Gly 
                165                 170                 175     


His Lys Gln Leu Thr Asp Cys Ile Ser Glu Phe Leu Lys Glu Glu Lys 
            180                 185                 190         


Leu Glu Gly Asp Asn Arg Tyr Phe Cys Glu Asn Cys Gln Ser Lys Gln 
        195                 200                 205             


Asn Ala Thr Arg Lys Ile Arg Leu Leu Ser Leu Pro Cys Thr Leu Asn 
    210                 215                 220                 


Leu Gln Leu Met Arg Phe Val Phe Asp Arg Gln Thr Gly His Lys Lys 
225                 230                 235                 240 


Lys Leu Asn Thr Tyr Ile Gly Phe Ser Glu Ile Leu Asp Met Glu Pro 
                245                 250                 255     


Tyr Val Glu His Lys Gly Gly Ser Tyr Val Tyr Glu Leu Ser Ala Val 
            260                 265                 270         


Leu Ile His Arg Gly Val Ser Ala Tyr Ser Gly His Tyr Ile Ala His 
        275                 280                 285             


Val Lys Asp Pro Gln Ser Gly Glu Trp Tyr Lys Phe Asn Asp Glu Asp 
    290                 295                 300                 


Ile Glu Lys Met Glu Gly Lys Lys Leu Gln Leu Gly Ile Glu Glu Asp 
305                 310                 315                 320 


Leu Ala Glu Pro Ser Lys Ser Gln Thr Arg Lys Pro Lys Cys Gly Lys 
                325                 330                 335     


Gly Thr His Cys Ser Arg Asn Ala Tyr Met Leu Val Tyr Arg Leu Gln 
            340                 345                 350         


Thr 
    


<210> 115
<211> 359
<212> PRT
<213> Homo sapiens

<400> 115
Thr Ala Ile Cys Ala Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Ile Leu Gln Ser Leu Ser Asn Ile Glu Gln Phe Cys Cys 
            20                  25                  30          


Tyr Phe Lys Glu Leu Pro Ala Val Glu Leu Arg Asn Gly Lys Thr Ala 
        35                  40                  45              


Gly Arg Arg Thr Tyr His Thr Arg Ser Gln Gly Asp Asn Asn Val Ser 
    50                  55                  60                  


Leu Val Glu Glu Phe Arg Lys Thr Leu Cys Ala Leu Trp Gln Gly Ser 
65                  70                  75                  80  


Gln Thr Ala Phe Ser Pro Glu Ser Leu Phe Tyr Val Val Trp Lys Ile 
                85                  90                  95      


Met Pro Asn Phe Arg Gly Tyr Gln Gln Gln Asp Ala His Glu Phe Met 
            100                 105                 110         


Arg Tyr Leu Leu Asp His Leu His Leu Glu Leu Gln Gly Gly Phe Asn 
        115                 120                 125             


Gly Val Ser Arg Ser Ala Ile Leu Gln Glu Asn Ser Thr Leu Ser Ala 
    130                 135                 140                 


Ser Asn Lys Cys Cys Ile Asn Gly Ala Ser Thr Val Val Thr Ala Ile 
145                 150                 155                 160 


Phe Gly Gly Ile Leu Gln Asn Glu Val Asn Cys Leu Ile Cys Gly Thr 
                165                 170                 175     


Glu Ser Arg Lys Phe Asp Pro Phe Leu Asp Leu Ser Leu Asp Ile Pro 
            180                 185                 190         


Ser Gln Phe Arg Ser Lys Arg Ser Lys Asn Gln Glu Asn Gly Pro Val 
        195                 200                 205             


Cys Ser Leu Arg Asp Cys Leu Arg Ser Phe Thr Asp Leu Glu Glu Leu 
    210                 215                 220                 


Asp Glu Thr Glu Leu Tyr Met Cys His Lys Cys Lys Lys Lys Gln Lys 
225                 230                 235                 240 


Ser Thr Lys Lys Phe Trp Ile Gln Lys Leu Pro Lys Val Leu Cys Leu 
                245                 250                 255     


His Leu Lys Arg Phe His Trp Thr Ala Tyr Leu Arg Asn Lys Val Asp 
            260                 265                 270         


Thr Tyr Val Glu Phe Pro Leu Arg Gly Leu Asp Met Lys Cys Tyr Leu 
        275                 280                 285             


Leu Glu Pro Glu Asn Ser Gly Pro Glu Ser Cys Leu Tyr Asp Leu Ala 
    290                 295                 300                 


Ala Val Val Val His His Gly Ser Gly Val Gly Ser Gly His Tyr Thr 
305                 310                 315                 320 


Ala Tyr Ala Thr His Glu Gly Arg Trp Phe His Phe Asn Asp Ser Thr 
                325                 330                 335     


Val Thr Leu Thr Asp Glu Glu Thr Val Val Lys Ala Lys Ala Tyr Ile 
            340                 345                 350         


Leu Phe Tyr Val Glu His Gln 
        355                 


<210> 116
<211> 300
<212> PRT
<213> Homo sapiens

<400> 116
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 117
<211> 708
<212> PRT
<213> Homo sapiens

<400> 117
Leu Pro Phe Val Gly Leu Asn Asn Leu Gly Asn Thr Cys Tyr Leu Asn 
1               5                   10                  15      


Ser Ile Leu Gln Val Leu Tyr Phe Cys Pro Gly Phe Lys Ser Gly Val 
            20                  25                  30          


Lys His Leu Phe Asn Ile Ile Ser Arg Lys Lys Glu Ala Leu Lys Asp 
        35                  40                  45              


Glu Ala Asn Gln Lys Asp Lys Gly Asn Cys Lys Glu Asp Ser Leu Ala 
    50                  55                  60                  


Ser Tyr Glu Leu Ile Cys Ser Leu Gln Ser Leu Ile Ile Ser Val Glu 
65                  70                  75                  80  


Gln Leu Gln Ala Ser Phe Leu Leu Asn Pro Glu Lys Tyr Thr Asp Glu 
                85                  90                  95      


Leu Ala Thr Gln Pro Arg Arg Leu Leu Asn Thr Leu Arg Glu Leu Asn 
            100                 105                 110         


Pro Met Tyr Glu Gly Tyr Leu Gln His Asp Ala Gln Glu Val Leu Gln 
        115                 120                 125             


Cys Ile Leu Gly Asn Ile Gln Glu Thr Cys Gln Leu Leu Lys Lys Glu 
    130                 135                 140                 


Glu Val Lys Asn Val Ala Glu Leu Pro Thr Lys Val Glu Glu Ile Pro 
145                 150                 155                 160 


His Pro Lys Glu Glu Met Asn Gly Ile Asn Ser Ile Glu Met Asp Ser 
                165                 170                 175     


Met Arg His Ser Glu Asp Phe Lys Glu Lys Leu Pro Lys Gly Asn Gly 
            180                 185                 190         


Lys Arg Lys Ser Asp Thr Glu Phe Gly Asn Met Lys Lys Lys Val Lys 
        195                 200                 205             


Leu Ser Lys Glu His Gln Ser Leu Glu Glu Asn Gln Arg Gln Thr Arg 
    210                 215                 220                 


Ser Lys Arg Lys Ala Thr Ser Asp Thr Leu Glu Ser Pro Pro Lys Ile 
225                 230                 235                 240 


Ile Pro Lys Tyr Ile Ser Glu Asn Glu Ser Pro Arg Pro Ser Gln Lys 
                245                 250                 255     


Lys Ser Arg Val Lys Ile Asn Trp Leu Lys Ser Ala Thr Lys Gln Pro 
            260                 265                 270         


Ser Ile Leu Ser Lys Phe Cys Ser Leu Gly Lys Ile Thr Thr Asn Gln 
        275                 280                 285             


Gly Val Lys Gly Gln Ser Lys Glu Asn Glu Cys Asp Pro Glu Glu Asp 
    290                 295                 300                 


Leu Gly Lys Cys Glu Ser Asp Asn Thr Thr Asn Gly Cys Gly Leu Glu 
305                 310                 315                 320 


Ser Pro Gly Asn Thr Val Thr Pro Val Asn Val Asn Glu Val Lys Pro 
                325                 330                 335     


Ile Asn Lys Gly Glu Glu Gln Ile Gly Phe Glu Leu Val Glu Lys Leu 
            340                 345                 350         


Phe Gln Gly Gln Leu Val Leu Arg Thr Arg Cys Leu Glu Cys Glu Ser 
        355                 360                 365             


Leu Thr Glu Arg Arg Glu Asp Phe Gln Asp Ile Ser Val Pro Val Gln 
    370                 375                 380                 


Glu Asp Glu Leu Ser Lys Val Glu Glu Ser Ser Glu Ile Ser Pro Glu 
385                 390                 395                 400 


Pro Lys Thr Glu Met Lys Thr Leu Arg Trp Ala Ile Ser Gln Phe Ala 
                405                 410                 415     


Ser Val Glu Arg Ile Val Gly Glu Asp Lys Tyr Phe Cys Glu Asn Cys 
            420                 425                 430         


His His Tyr Thr Glu Ala Glu Arg Ser Leu Leu Phe Asp Lys Met Pro 
        435                 440                 445             


Glu Val Ile Thr Ile His Leu Lys Cys Phe Ala Ala Ser Gly Leu Glu 
    450                 455                 460                 


Phe Asp Cys Tyr Gly Gly Gly Leu Ser Lys Ile Asn Thr Pro Leu Leu 
465                 470                 475                 480 


Thr Pro Leu Lys Leu Ser Leu Glu Glu Trp Ser Thr Lys Pro Thr Asn 
                485                 490                 495     


Asp Ser Tyr Gly Leu Phe Ala Val Val Met His Ser Gly Ile Thr Ile 
            500                 505                 510         


Ser Ser Gly His Tyr Thr Ala Ser Val Lys Val Thr Asp Leu Asn Ser 
        515                 520                 525             


Leu Glu Leu Asp Lys Gly Asn Phe Val Val Asp Gln Met Cys Glu Ile 
    530                 535                 540                 


Gly Lys Pro Glu Pro Leu Asn Glu Glu Glu Ala Arg Gly Val Val Glu 
545                 550                 555                 560 


Asn Tyr Asn Asp Glu Glu Val Ser Ile Arg Val Gly Gly Asn Thr Gln 
                565                 570                 575     


Pro Ser Lys Val Leu Asn Lys Lys Asn Val Glu Ala Ile Gly Leu Leu 
            580                 585                 590         


Gly Gly Gln Lys Ser Lys Ala Asp Tyr Glu Leu Tyr Asn Lys Ala Ser 
        595                 600                 605             


Asn Pro Asp Lys Val Ala Ser Thr Ala Phe Ala Glu Asn Arg Asn Ser 
    610                 615                 620                 


Glu Thr Ser Asp Thr Thr Gly Thr His Glu Ser Asp Arg Asn Lys Glu 
625                 630                 635                 640 


Ser Ser Asp Gln Thr Gly Ile Asn Ile Ser Gly Phe Glu Asn Lys Ile 
                645                 650                 655     


Ser Tyr Val Val Gln Ser Leu Lys Glu Tyr Glu Gly Lys Trp Leu Leu 
            660                 665                 670         


Phe Asp Asp Ser Glu Val Lys Val Thr Glu Glu Lys Asp Phe Leu Asn 
        675                 680                 685             


Ser Leu Ser Pro Ser Thr Ser Pro Thr Ser Thr Pro Tyr Leu Leu Phe 
    690                 695                 700                 


Tyr Lys Lys Leu 
705             


<210> 118
<211> 1164
<212> PRT
<213> Homo sapiens

<400> 118
Phe Thr Asn Leu Ser Gly Ile Arg Asn Gln Gly Gly Thr Cys Tyr Leu 
1               5                   10                  15      


Asn Ser Leu Leu Gln Thr Leu His Phe Thr Pro Glu Phe Arg Glu Ala 
            20                  25                  30          


Leu Phe Ser Leu Gly Pro Glu Glu Leu Gly Leu Phe Glu Asp Lys Asp 
        35                  40                  45              


Lys Pro Asp Ala Lys Val Arg Ile Ile Pro Leu Gln Leu Gln Arg Leu 
    50                  55                  60                  


Phe Ala Gln Leu Leu Leu Leu Asp Gln Glu Ala Ala Ser Thr Ala Asp 
65                  70                  75                  80  


Leu Thr Asp Ser Phe Gly Trp Thr Ser Asn Glu Glu Met Arg Gln His 
                85                  90                  95      


Asp Val Gln Glu Leu Asn Arg Ile Leu Phe Ser Ala Leu Glu Thr Ser 
            100                 105                 110         


Leu Val Gly Thr Ser Gly His Asp Leu Ile Tyr Arg Leu Tyr His Gly 
        115                 120                 125             


Thr Ile Val Asn Gln Ile Val Cys Lys Glu Cys Lys Asn Val Ser Glu 
    130                 135                 140                 


Arg Gln Glu Asp Phe Leu Asp Leu Thr Val Ala Val Lys Asn Val Ser 
145                 150                 155                 160 


Gly Leu Glu Asp Ala Leu Trp Asn Met Tyr Val Glu Glu Glu Val Phe 
                165                 170                 175     


Asp Cys Asp Asn Leu Tyr His Cys Gly Thr Cys Asp Arg Leu Val Lys 
            180                 185                 190         


Ala Ala Lys Ser Ala Lys Leu Arg Lys Leu Pro Pro Phe Leu Thr Val 
        195                 200                 205             


Ser Leu Leu Arg Phe Asn Phe Asp Phe Val Lys Cys Glu Arg Tyr Lys 
    210                 215                 220                 


Glu Thr Ser Cys Tyr Thr Phe Pro Leu Arg Ile Asn Leu Lys Pro Phe 
225                 230                 235                 240 


Cys Glu Gln Ser Glu Leu Asp Asp Leu Glu Tyr Ile Tyr Asp Leu Phe 
                245                 250                 255     


Ser Val Ile Ile His Lys Gly Gly Cys Tyr Gly Gly His Tyr His Val 
            260                 265                 270         


Tyr Ile Lys Asp Val Asp His Leu Gly Asn Trp Gln Phe Gln Glu Glu 
        275                 280                 285             


Lys Ser Lys Pro Asp Val Asn Leu Lys Asp Leu Gln Ser Glu Glu Glu 
    290                 295                 300                 


Ile Asp His Pro Leu Met Ile Leu Lys Ala Ile Leu Leu Glu Glu Asn 
305                 310                 315                 320 


Asn Leu Ile Pro Val Asp Gln Leu Gly Gln Lys Leu Leu Lys Lys Ile 
                325                 330                 335     


Gly Ile Ser Trp Asn Lys Lys Tyr Arg Lys Gln His Gly Pro Leu Arg 
            340                 345                 350         


Lys Phe Leu Gln Leu His Ser Gln Ile Phe Leu Leu Ser Ser Asp Glu 
        355                 360                 365             


Ser Thr Val Arg Leu Leu Lys Asn Ser Ser Leu Gln Ala Glu Ser Asp 
    370                 375                 380                 


Phe Gln Arg Asn Asp Gln Gln Ile Phe Lys Met Leu Pro Pro Glu Ser 
385                 390                 395                 400 


Pro Gly Leu Asn Asn Ser Ile Ser Cys Pro His Trp Phe Asp Ile Asn 
                405                 410                 415     


Asp Ser Lys Val Gln Pro Ile Arg Glu Lys Asp Ile Glu Gln Gln Phe 
            420                 425                 430         


Gln Gly Lys Glu Ser Ala Tyr Met Leu Phe Tyr Arg Lys Ser Gln Leu 
        435                 440                 445             


Gln Arg Pro Pro Glu Ala Arg Ala Asn Pro Arg Tyr Gly Val Pro Cys 
    450                 455                 460                 


His Leu Leu Asn Glu Met Asp Ala Ala Asn Ile Glu Leu Gln Thr Lys 
465                 470                 475                 480 


Arg Ala Glu Cys Asp Ser Ala Asn Asn Thr Phe Glu Leu His Leu His 
                485                 490                 495     


Leu Gly Pro Gln Tyr His Phe Phe Asn Gly Ala Leu His Pro Val Val 
            500                 505                 510         


Ser Gln Thr Glu Ser Val Trp Asp Leu Thr Phe Asp Lys Arg Lys Thr 
        515                 520                 525             


Leu Gly Asp Leu Arg Gln Ser Ile Phe Gln Leu Leu Glu Phe Trp Glu 
    530                 535                 540                 


Gly Asp Met Val Leu Ser Val Ala Lys Leu Val Pro Ala Gly Leu His 
545                 550                 555                 560 


Ile Tyr Gln Ser Leu Gly Gly Asp Glu Leu Thr Leu Cys Glu Thr Glu 
                565                 570                 575     


Ile Ala Asp Gly Glu Asp Ile Phe Val Trp Asn Gly Val Glu Val Gly 
            580                 585                 590         


Gly Val His Ile Gln Thr Gly Ile Asp Cys Glu Pro Leu Leu Leu Asn 
        595                 600                 605             


Val Leu His Leu Asp Thr Ser Ser Asp Gly Glu Lys Cys Cys Gln Val 
    610                 615                 620                 


Ile Glu Ser Pro His Val Phe Pro Ala Asn Ala Glu Val Gly Thr Val 
625                 630                 635                 640 


Leu Thr Ala Leu Ala Ile Pro Ala Gly Val Ile Phe Ile Asn Ser Ala 
                645                 650                 655     


Gly Cys Pro Gly Gly Glu Gly Trp Thr Ala Ile Pro Lys Glu Asp Met 
            660                 665                 670         


Arg Lys Thr Phe Arg Glu Gln Gly Leu Arg Asn Gly Ser Ser Ile Leu 
        675                 680                 685             


Ile Gln Asp Ser His Asp Asp Asn Ser Leu Leu Thr Lys Glu Glu Lys 
    690                 695                 700                 


Trp Val Thr Ser Met Asn Glu Ile Asp Trp Leu His Val Lys Asn Leu 
705                 710                 715                 720 


Cys Gln Leu Glu Ser Glu Glu Lys Gln Val Lys Ile Ser Ala Thr Val 
                725                 730                 735     


Asn Thr Met Val Phe Asp Ile Arg Ile Lys Ala Ile Lys Glu Leu Lys 
            740                 745                 750         


Leu Met Lys Glu Leu Ala Asp Asn Ser Cys Leu Arg Pro Ile Asp Arg 
        755                 760                 765             


Asn Gly Lys Leu Leu Cys Pro Val Pro Asp Ser Tyr Thr Leu Lys Glu 
    770                 775                 780                 


Ala Glu Leu Lys Met Gly Ser Ser Leu Gly Leu Cys Leu Gly Lys Ala 
785                 790                 795                 800 


Pro Ser Ser Ser Gln Leu Phe Leu Phe Phe Ala Met Gly Ser Asp Val 
                805                 810                 815     


Gln Pro Gly Thr Glu Met Glu Ile Val Val Glu Glu Thr Ile Ser Val 
            820                 825                 830         


Arg Asp Cys Leu Lys Leu Met Leu Lys Lys Ser Gly Leu Gln Gly Asp 
        835                 840                 845             


Ala Trp His Leu Arg Lys Met Asp Trp Cys Tyr Glu Ala Gly Glu Pro 
    850                 855                 860                 


Leu Cys Glu Glu Asp Ala Thr Leu Lys Glu Leu Leu Ile Cys Ser Gly 
865                 870                 875                 880 


Asp Thr Leu Leu Leu Ile Glu Gly Gln Leu Pro Pro Leu Gly Phe Leu 
                885                 890                 895     


Lys Val Pro Ile Trp Trp Tyr Gln Leu Gln Gly Pro Ser Gly His Trp 
            900                 905                 910         


Glu Ser His Gln Asp Gln Thr Asn Cys Thr Ser Ser Trp Gly Arg Val 
        915                 920                 925             


Trp Arg Ala Thr Ser Ser Gln Gly Ala Ser Gly Asn Glu Pro Ala Gln 
    930                 935                 940                 


Val Ser Leu Leu Tyr Leu Gly Asp Ile Glu Ile Ser Glu Asp Ala Thr 
945                 950                 955                 960 


Leu Ala Glu Leu Lys Ser Gln Ala Met Thr Leu Pro Pro Phe Leu Glu 
                965                 970                 975     


Phe Gly Val Pro Ser Pro Ala His Leu Arg Ala Trp Thr Val Glu Arg 
            980                 985                 990         


Lys Arg Pro Gly Arg Leu Leu Arg  Thr Asp Arg Gln Pro  Leu Arg Glu 
        995                 1000                 1005             


Tyr Lys  Leu Gly Arg Arg Ile  Glu Ile Cys Leu Glu  Pro Leu Gln 
    1010                 1015                 1020             


Lys Gly  Glu Asn Leu Gly Pro  Gln Asp Val Leu Leu  Arg Thr Gln 
    1025                 1030                 1035             


Val Arg  Ile Pro Gly Glu Arg  Thr Tyr Ala Pro Ala  Leu Asp Leu 
    1040                 1045                 1050             


Val Trp  Asn Ala Ala Gln Gly  Gly Thr Ala Gly Ser  Leu Arg Gln 
    1055                 1060                 1065             


Arg Val  Ala Asp Phe Tyr Arg  Leu Pro Val Glu Lys  Ile Glu Ile 
    1070                 1075                 1080             


Ala Lys  Tyr Phe Pro Glu Lys  Phe Glu Trp Leu Pro  Ile Ser Ser 
    1085                 1090                 1095             


Trp Asn  Gln Gln Ile Thr Lys  Arg Lys Lys Lys Lys  Lys Gln Asp 
    1100                 1105                 1110             


Tyr Leu  Gln Gly Ala Pro Tyr  Tyr Leu Lys Asp Gly  Asp Thr Ile 
    1115                 1120                 1125             


Gly Val  Lys Asn Leu Leu Ile  Asp Asp Asp Asp Asp  Phe Ser Thr 
    1130                 1135                 1140             


Ile Arg  Asp Asp Thr Gly Lys  Glu Lys Gln Lys Gln  Arg Ala Leu 
    1145                 1150                 1155             


Gly Arg  Arg Lys Ser Gln 
    1160                 


<210> 119
<211> 311
<212> PRT
<213> Homo sapiens

<400> 119
Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys Ala Val 
            20                  25                  30          


Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val Pro Leu 
        35                  40                  45              


Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys Pro Val 
    50                  55                  60                  


Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu Asp Ser 
65                  70                  75                  80  


Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu Asp Asn 
                85                  90                  95      


Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile Pro Lys 
            100                 105                 110         


Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu Val Asp 
        115                 120                 125             


Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu Ser Ile 
    130                 135                 140                 


Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val Ala Val 
145                 150                 155                 160 


Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His Gly Leu 
                165                 170                 175     


Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro Val Leu 
            180                 185                 190         


His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp Gln Asn 
        195                 200                 205             


Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro Leu Asp 
    210                 215                 220                 


Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr Ile Leu 
225                 230                 235                 240 


His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His Tyr Val 
                245                 250                 255     


Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe Asp Asp 
            260                 265                 270         


Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His Asn Tyr 
        275                 280                 285             


Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn Ala Tyr 
    290                 295                 300                 


Met Leu Val Tyr Ile Arg Glu 
305                 310     


<210> 120
<211> 344
<212> PRT
<213> Homo sapiens

<400> 120
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Ala Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 121
<211> 344
<212> PRT
<213> Homo sapiens

<400> 121
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Leu Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 122
<211> 344
<212> PRT
<213> Homo sapiens

<400> 122
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Lys Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Phe Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Ile Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Arg Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp Arg His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Asn Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Pro 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Ser Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Val 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 123
<211> 307
<212> PRT
<213> Homo sapiens

<400> 123
Trp Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys Cys Leu Asn 
1               5                   10                  15      


Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Ala Arg Ile Leu 
            20                  25                  30          


Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg Arg Ser Val 
        35                  40                  45              


Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp Ser Arg Gln 
    50                  55                  60                  


Lys Ala Val Trp Pro Leu Glu Leu Ala Tyr Cys Leu Gln Lys Tyr Asn 
65                  70                  75                  80  


Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr Leu Lys Leu 
                85                  90                  95      


Trp Asn Leu Ile Lys Asp Gln Ile Ala Asp Val His Leu Val Glu Arg 
            100                 105                 110         


Leu Gln Ala Leu Tyr Met Ile Arg Met Lys Asp Ser Leu Ile Cys Leu 
        115                 120                 125             


Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu Thr Leu Arg 
    130                 135                 140                 


Leu Ser Phe Phe Asp Val Asp Ser Lys Pro Leu Lys Thr Leu Glu Asp 
145                 150                 155                 160 


Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser Lys Ser Lys 
                165                 170                 175     


Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys Gln Val Leu 
            180                 185                 190         


Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu Met Arg Phe 
        195                 200                 205             


Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser Leu Tyr Phe 
    210                 215                 220                 


Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys Arg Glu Ser 
225                 230                 235                 240 


Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu Phe Ala Val 
                245                 250                 255     


Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys Val Tyr Ile 
            260                 265                 270         


Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp Ser Asn Ile 
        275                 280                 285             


Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly Asn Pro Asn 
    290                 295                 300                 


Tyr His Trp 
305         


<210> 124
<211> 511
<212> PRT
<213> Homo sapiens

<400> 124
Ser Glu Thr Gly Lys Thr Gly Leu Ile Asn Leu Gly Asn Thr Cys Tyr 
1               5                   10                  15      


Met Asn Ser Val Ile Gln Ala Leu Phe Met Ala Thr Asp Phe Arg Arg 
            20                  25                  30          


Gln Val Leu Ser Leu Asn Leu Asn Gly Cys Asn Ser Leu Met Lys Lys 
        35                  40                  45              


Leu Gln His Leu Phe Ala Phe Leu Ala His Thr Gln Arg Glu Ala Tyr 
    50                  55                  60                  


Ala Pro Arg Ile Phe Phe Glu Ala Ser Arg Pro Pro Trp Phe Thr Pro 
65                  70                  75                  80  


Arg Ser Gln Gln Asp Cys Ser Glu Tyr Leu Arg Phe Leu Leu Asp Arg 
                85                  90                  95      


Leu His Glu Glu Glu Lys Ile Leu Lys Val Gln Ala Ser His Lys Pro 
            100                 105                 110         


Ser Glu Ile Leu Glu Cys Ser Glu Thr Ser Leu Gln Glu Val Ala Ser 
        115                 120                 125             


Lys Ala Ala Val Leu Thr Glu Thr Pro Arg Thr Ser Asp Gly Glu Lys 
    130                 135                 140                 


Thr Leu Ile Glu Lys Met Phe Gly Gly Lys Leu Arg Thr His Ile Arg 
145                 150                 155                 160 


Cys Leu Asn Cys Arg Ser Thr Ser Gln Lys Val Glu Ala Phe Thr Asp 
                165                 170                 175     


Leu Ser Leu Ala Phe Cys Pro Ser Ser Ser Leu Glu Asn Met Ser Val 
            180                 185                 190         


Gln Asp Pro Ala Ser Ser Pro Ser Ile Gln Asp Gly Gly Leu Met Gln 
        195                 200                 205             


Ala Ser Val Pro Gly Pro Ser Glu Glu Pro Val Val Tyr Asn Pro Thr 
    210                 215                 220                 


Thr Ala Ala Phe Ile Cys Asp Ser Leu Val Asn Glu Lys Thr Ile Gly 
225                 230                 235                 240 


Ser Pro Pro Asn Glu Phe Tyr Cys Ser Glu Asn Thr Ser Val Pro Asn 
                245                 250                 255     


Glu Ser Asn Lys Ile Leu Val Asn Lys Asp Val Pro Gln Lys Pro Gly 
            260                 265                 270         


Gly Glu Thr Thr Pro Ser Val Thr Asp Leu Leu Asn Tyr Phe Leu Ala 
        275                 280                 285             


Pro Glu Ile Leu Thr Gly Asp Asn Gln Tyr Tyr Cys Glu Asn Cys Ala 
    290                 295                 300                 


Ser Leu Gln Asn Ala Glu Lys Thr Met Gln Ile Thr Glu Glu Pro Glu 
305                 310                 315                 320 


Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Tyr Asp Gln Lys Tyr His 
                325                 330                 335     


Val Arg Arg Lys Ile Leu Asp Asn Val Ser Leu Pro Leu Val Leu Glu 
            340                 345                 350         


Leu Pro Val Lys Arg Ile Thr Ser Phe Ser Ser Leu Ser Glu Ser Trp 
        355                 360                 365             


Ser Val Asp Val Asp Phe Thr Asp Leu Ser Glu Asn Leu Ala Lys Lys 
    370                 375                 380                 


Leu Lys Pro Ser Gly Thr Asp Glu Ala Ser Cys Thr Lys Leu Val Pro 
385                 390                 395                 400 


Tyr Leu Leu Ser Ser Val Val Val His Ser Gly Ile Ser Ser Glu Ser 
                405                 410                 415     


Gly His Tyr Tyr Ser Tyr Ala Arg Asn Ile Thr Ser Thr Asp Ser Ser 
            420                 425                 430         


Tyr Gln Met Tyr His Gln Ser Glu Ala Leu Ala Leu Ala Ser Ser Gln 
        435                 440                 445             


Ser His Leu Leu Gly Arg Asp Ser Pro Ser Ala Val Phe Glu Gln Asp 
    450                 455                 460                 


Leu Glu Asn Lys Glu Met Ser Lys Glu Trp Phe Leu Phe Asn Asp Ser 
465                 470                 475                 480 


Arg Val Thr Phe Thr Ser Phe Gln Ser Val Gln Lys Ile Thr Ser Arg 
                485                 490                 495     


Phe Pro Lys Asp Thr Ala Tyr Val Leu Leu Tyr Lys Lys Gln His 
            500                 505                 510     


<210> 125
<211> 616
<212> PRT
<213> Homo sapiens

<400> 125
Arg Pro Pro Gly Ala Gln Gly Leu Lys Asn His Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Val Val Gln Cys Leu Ser Asn Thr Asp Leu Leu Ala Glu 
            20                  25                  30          


Phe Leu Ala Leu Gly Arg Tyr Arg Ala Ala Pro Gly Arg Ala Glu Val 
        35                  40                  45              


Thr Glu Gln Leu Ala Ala Leu Val Arg Ala Leu Trp Thr Arg Glu Tyr 
    50                  55                  60                  


Thr Pro Gln Leu Ser Ala Glu Phe Lys Asn Ala Val Ser Lys Tyr Gly 
65                  70                  75                  80  


Ser Gln Phe Gln Gly Asn Ser Gln His Asp Ala Leu Glu Phe Leu Leu 
                85                  90                  95      


Trp Leu Leu Asp Arg Val His Glu Asp Leu Glu Gly Ser Ser Arg Gly 
            100                 105                 110         


Pro Val Ser Glu Lys Leu Pro Pro Glu Ala Thr Lys Thr Ser Glu Asn 
        115                 120                 125             


Cys Leu Ser Pro Ser Ala Gln Leu Pro Leu Gly Gln Ser Phe Val Gln 
    130                 135                 140                 


Ser His Phe Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys 
145                 150                 155                 160 


Leu Lys Gln Ser Asn Thr Phe Asp Pro Phe Leu Cys Val Ser Leu Pro 
                165                 170                 175     


Ile Pro Leu Arg Gln Thr Arg Phe Leu Ser Val Thr Leu Val Phe Pro 
            180                 185                 190         


Ser Lys Ser Gln Arg Phe Leu Arg Val Gly Leu Ala Val Pro Ile Leu 
        195                 200                 205             


Ser Thr Val Ala Ala Leu Arg Lys Met Val Ala Glu Glu Gly Gly Val 
    210                 215                 220                 


Pro Ala Asp Glu Val Ile Leu Val Glu Leu Tyr Pro Ser Gly Phe Gln 
225                 230                 235                 240 


Arg Ser Phe Phe Asp Glu Glu Asp Leu Asn Thr Ile Ala Glu Gly Asp 
                245                 250                 255     


Asn Val Tyr Ala Phe Gln Val Pro Pro Ser Pro Ser Gln Gly Thr Leu 
            260                 265                 270         


Ser Ala His Pro Leu Gly Leu Ser Ala Ser Pro Arg Leu Ala Ala Arg 
        275                 280                 285             


Glu Gly Gln Arg Phe Ser Leu Ser Leu His Ser Glu Ser Lys Val Leu 
    290                 295                 300                 


Ile Leu Phe Cys Asn Leu Val Gly Ser Gly Gln Gln Ala Ser Arg Phe 
305                 310                 315                 320 


Gly Pro Pro Phe Leu Ile Arg Glu Asp Arg Ala Val Ser Trp Ala Gln 
                325                 330                 335     


Leu Gln Gln Ser Ile Leu Ser Lys Val Arg His Leu Met Lys Ser Glu 
            340                 345                 350         


Ala Pro Val Gln Asn Leu Gly Ser Leu Phe Ser Ile Arg Val Val Gly 
        355                 360                 365             


Leu Ser Val Ala Cys Ser Tyr Leu Ser Pro Lys Asp Ser Arg Pro Leu 
    370                 375                 380                 


Cys His Trp Ala Val Asp Arg Val Leu His Leu Arg Arg Pro Gly Gly 
385                 390                 395                 400 


Pro Pro His Val Lys Leu Ala Val Glu Trp Asp Ser Ser Val Lys Glu 
                405                 410                 415     


Arg Leu Phe Gly Ser Leu Gln Glu Glu Arg Ala Gln Asp Ala Asp Ser 
            420                 425                 430         


Val Trp Gln Gln Gln Gln Ala His Gln Gln His Ser Cys Thr Leu Asp 
        435                 440                 445             


Glu Cys Phe Gln Phe Tyr Thr Lys Glu Glu Gln Leu Ala Gln Asp Asp 
    450                 455                 460                 


Ala Trp Lys Cys Pro His Cys Gln Val Leu Gln Gln Gly Met Val Lys 
465                 470                 475                 480 


Leu Ser Leu Trp Thr Leu Pro Asp Ile Leu Ile Ile His Leu Lys Arg 
                485                 490                 495     


Phe Cys Gln Val Gly Glu Arg Arg Asn Lys Leu Ser Thr Leu Val Lys 
            500                 505                 510         


Phe Pro Leu Ser Gly Leu Asn Met Ala Pro His Val Ala Gln Arg Ser 
        515                 520                 525             


Thr Ser Pro Glu Ala Gly Leu Gly Pro Trp Pro Ser Trp Lys Gln Pro 
    530                 535                 540                 


Asp Cys Leu Pro Thr Ser Tyr Pro Leu Asp Phe Leu Tyr Asp Leu Tyr 
545                 550                 555                 560 


Ala Val Cys Asn His His Gly Asn Leu Gln Gly Gly His Tyr Thr Ala 
                565                 570                 575     


Tyr Cys Arg Asn Ser Leu Asp Gly Gln Trp Tyr Ser Tyr Asp Asp Ser 
            580                 585                 590         


Thr Val Glu Pro Leu Arg Glu Asp Glu Val Asn Thr Arg Gly Ala Tyr 
        595                 600                 605             


Ile Leu Phe Tyr Gln Lys Arg Asn 
    610                 615     


<210> 126
<211> 339
<212> PRT
<213> Homo sapiens

<400> 126
Ser Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp 
            20                  25                  30          


Tyr Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn 
        35                  40                  45              


Ala His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile 
    50                  55                  60                  


Trp Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr 
65                  70                  75                  80  


Gln Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp 
                85                  90                  95      


Ala Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val 
            100                 105                 110         


Asn Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His 
        115                 120                 125             


Leu Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu 
    130                 135                 140                 


Arg Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser 
145                 150                 155                 160 


Ser Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro 
                165                 170                 175     


Phe Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val 
            180                 185                 190         


Thr Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp 
        195                 200                 205             


Gly Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys 
    210                 215                 220                 


Ile Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His 
225                 230                 235                 240 


Leu Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr 
                245                 250                 255     


Phe Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser 
            260                 265                 270         


Glu Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His 
        275                 280                 285             


Ser Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro 
    290                 295                 300                 


Gly Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met 
305                 310                 315                 320 


Ser Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu 
                325                 330                 335     


Leu Ala Ser 
            


<210> 127
<211> 628
<212> PRT
<213> Homo sapiens

<400> 127
Leu Ser Val Arg Gly Ile Thr Asn Leu Gly Asn Thr Cys Phe Phe Asn 
1               5                   10                  15      


Ala Val Met Gln Asn Leu Ala Gln Thr Tyr Thr Leu Thr Asp Leu Met 
            20                  25                  30          


Asn Glu Ile Lys Glu Ser Ser Thr Lys Leu Lys Ile Phe Pro Ser Ser 
        35                  40                  45              


Asp Ser Gln Leu Asp Pro Leu Val Val Glu Leu Ser Arg Pro Gly Pro 
    50                  55                  60                  


Leu Thr Ser Ala Leu Phe Leu Phe Leu His Ser Met Lys Glu Thr Glu 
65                  70                  75                  80  


Lys Gly Pro Leu Ser Pro Lys Val Leu Phe Asn Gln Leu Cys Gln Lys 
                85                  90                  95      


Ala Pro Arg Phe Lys Asp Phe Gln Gln Gln Asp Ser Gln Glu Leu Leu 
            100                 105                 110         


His Tyr Leu Leu Asp Ala Val Arg Thr Glu Glu Thr Lys Arg Ile Gln 
        115                 120                 125             


Ala Ser Ile Leu Lys Ala Phe Asn Asn Pro Thr Thr Lys Thr Ala Asp 
    130                 135                 140                 


Asp Glu Thr Arg Lys Lys Val Lys Ala Tyr Gly Lys Glu Gly Val Lys 
145                 150                 155                 160 


Met Asn Phe Ile Asp Arg Ile Phe Ile Gly Glu Leu Thr Ser Thr Val 
                165                 170                 175     


Met Cys Glu Glu Cys Ala Asn Ile Ser Thr Val Lys Asp Pro Phe Ile 
            180                 185                 190         


Asp Ile Ser Leu Pro Ile Ile Glu Glu Arg Val Ser Lys Pro Leu Leu 
        195                 200                 205             


Trp Gly Arg Met Asn Lys Tyr Arg Ser Leu Arg Glu Thr Asp His Asp 
    210                 215                 220                 


Arg Tyr Ser Gly Asn Val Thr Ile Glu Asn Ile His Gln Pro Arg Ala 
225                 230                 235                 240 


Ala Lys Lys His Ser Ser Ser Lys Asp Lys Ser Gln Leu Ile His Asp 
                245                 250                 255     


Arg Lys Cys Ile Arg Lys Leu Ser Ser Gly Glu Thr Val Thr Tyr Gln 
            260                 265                 270         


Lys Asn Glu Asn Leu Glu Met Asn Gly Asp Ser Leu Met Phe Ala Ser 
        275                 280                 285             


Leu Met Asn Ser Glu Ser Arg Leu Asn Glu Ser Pro Thr Asp Asp Ser 
    290                 295                 300                 


Glu Lys Glu Ala Ser His Ser Glu Ser Asn Val Asp Ala Asp Ser Glu 
305                 310                 315                 320 


Pro Ser Glu Ser Glu Ser Ala Ser Lys Gln Thr Gly Leu Phe Arg Ser 
                325                 330                 335     


Ser Ser Gly Ser Gly Val Gln Pro Asp Gly Pro Leu Tyr Pro Leu Ser 
            340                 345                 350         


Ala Gly Lys Leu Leu Tyr Thr Lys Glu Thr Asp Ser Gly Asp Lys Glu 
        355                 360                 365             


Met Ala Glu Ala Ile Ser Glu Leu Arg Leu Ser Ser Thr Val Thr Gly 
    370                 375                 380                 


Asp Gln Asp Phe Asp Arg Glu Asn Gln Pro Leu Asn Ile Ser Asn Asn 
385                 390                 395                 400 


Leu Cys Phe Leu Glu Gly Lys His Leu Arg Ser Tyr Ser Pro Gln Asn 
                405                 410                 415     


Ala Phe Gln Thr Leu Ser Gln Ser Tyr Ile Thr Thr Ser Lys Glu Cys 
            420                 425                 430         


Ser Ile Gln Ser Cys Leu Tyr Gln Phe Thr Ser Met Glu Leu Leu Met 
        435                 440                 445             


Gly Asn Asn Lys Leu Leu Cys Glu Asn Cys Thr Lys Asn Lys Gln Lys 
    450                 455                 460                 


Tyr Gln Glu Glu Thr Ser Phe Ala Glu Lys Lys Val Glu Gly Val Tyr 
465                 470                 475                 480 


Thr Asn Ala Arg Lys Gln Leu Leu Ile Ser Ala Val Pro Ala Val Leu 
                485                 490                 495     


Ile Leu His Leu Lys Arg Phe His Gln Ala Gly Leu Ser Leu Arg Lys 
            500                 505                 510         


Val Asn Arg His Val Asp Phe Pro Leu Met Leu Asp Leu Ala Pro Phe 
        515                 520                 525             


Cys Ser Ala Thr Cys Lys Asn Ala Ser Val Gly Asp Lys Val Leu Tyr 
    530                 535                 540                 


Gly Leu Tyr Gly Ile Val Glu His Ser Gly Ser Met Arg Glu Gly His 
545                 550                 555                 560 


Tyr Thr Ala Tyr Val Lys Val Arg Thr Pro Ser Arg Lys Leu Ser Glu 
                565                 570                 575     


His Asn Thr Lys Lys Lys Asn Val Pro Gly Leu Lys Ala Ala Asp Asn 
            580                 585                 590         


Glu Ser Ala Gly Gln Trp Val His Val Ser Asp Thr Tyr Leu Gln Val 
        595                 600                 605             


Val Pro Glu Ser Arg Ala Leu Ser Ala Gln Ala Tyr Leu Leu Phe Tyr 
    610                 615                 620                 


Glu Arg Val Leu 
625             


<210> 128
<211> 876
<212> PRT
<213> Homo sapiens

<400> 128
Thr Glu Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln 
            20                  25                  30          


Tyr Phe Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro 
        35                  40                  45              


Ile Gly Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln 
    50                  55                  60                  


Glu Leu Trp Ser Gly Thr Gln Lys Asn Val Ala Pro Leu Lys Leu Arg 
65                  70                  75                  80  


Trp Thr Ile Ala Lys Tyr Ala Pro Arg Phe Asn Gly Phe Gln Gln Gln 
                85                  90                  95      


Asp Ser Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp 
            100                 105                 110         


Leu Asn Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp 
        115                 120                 125             


Gly Arg Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu 
    130                 135                 140                 


Arg Arg Asn Arg Ser Ile Val Val Asp Leu Phe His Gly Gln Leu Arg 
145                 150                 155                 160 


Ser Gln Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp 
                165                 170                 175     


Pro Phe Asn Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met His 
            180                 185                 190         


Leu Glu Ile Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr 
        195                 200                 205             


Gly Leu Arg Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln 
    210                 215                 220                 


Leu Ser Asp Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu 
225                 230                 235                 240 


Val His Gly Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val 
                245                 250                 255     


Arg Leu Ser Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro 
            260                 265                 270         


Val Ser Pro Ile Ser Ala Ser Ser Pro Thr Gln Thr Asp Phe Ser Ser 
        275                 280                 285             


Ser Pro Ser Thr Asn Glu Met Phe Thr Leu Thr Thr Asn Gly Asp Leu 
    290                 295                 300                 


Pro Arg Pro Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro 
305                 310                 315                 320 


Cys Gly Thr Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met 
                325                 330                 335     


Pro Ser Leu Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His 
            340                 345                 350         


Arg Lys Met Met Arg Thr Glu Leu Tyr Phe Leu Ser Ser Gln Lys Asn 
        355                 360                 365             


Arg Pro Ser Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His 
    370                 375                 380                 


Thr Arg Lys Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Arg 
385                 390                 395                 400 


Leu Ala Ser Pro Leu Pro Pro Gln Glu Ala Ser Asn His Ala Gln Asp 
                405                 410                 415     


Cys Asp Asp Ser Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val 
            420                 425                 430         


Gln Lys Asp Gly Asn Ser Cys Ala Trp Cys Pro Trp Tyr Arg Phe Cys 
        435                 440                 445             


Arg Gly Cys Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn 
    450                 455                 460                 


Ala Tyr Ile Ala Val Asp Trp Asp Pro Thr Ala Leu His Leu Arg Tyr 
465                 470                 475                 480 


Gln Thr Ser Gln Glu Arg Val Val Asp Glu His Glu Ser Val Glu Gln 
                485                 490                 495     


Ser Arg Arg Ala Gln Ala Glu Pro Ile Asn Leu Asp Ser Cys Leu Arg 
            500                 505                 510         


Ala Phe Thr Ser Glu Glu Glu Leu Gly Glu Asn Glu Met Tyr Tyr Cys 
        515                 520                 525             


Ser Lys Cys Lys Thr His Cys Leu Ala Thr Lys Lys Leu Asp Leu Trp 
    530                 535                 540                 


Arg Leu Pro Pro Ile Leu Ile Ile His Leu Lys Arg Phe Gln Phe Val 
545                 550                 555                 560 


Asn Gly Arg Trp Ile Lys Ser Gln Lys Ile Val Lys Phe Pro Arg Glu 
                565                 570                 575     


Ser Phe Asp Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu Cys 
            580                 585                 590         


Gln His Lys Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Glu Pro Arg 
        595                 600                 605             


Ile Leu Ala Arg Glu Val Lys Lys Val Asp Ala Gln Ser Ser Ala Gly 
    610                 615                 620                 


Glu Glu Asp Val Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn 
625                 630                 635                 640 


Ile Ile Ser Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser Gly 
                645                 650                 655     


Thr Ser Cys Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Ser Pro Arg 
            660                 665                 670         


Thr Leu Gly Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly Ser 
        675                 680                 685             


Lys Asn Lys Leu Ser Ser Ser Lys Glu Asn Leu Asp Ala Ser Lys Glu 
    690                 695                 700                 


Asn Gly Ala Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser Arg Gly 
705                 710                 715                 720 


His Val Leu Gly Gly Ser Gln Pro Glu Leu Val Thr Pro Gln Asp His 
                725                 730                 735     


Glu Val Ala Leu Ala Asn Gly Phe Leu Tyr Glu His Glu Ala Cys Gly 
            740                 745                 750         


Asn Gly Tyr Ser Asn Gly Gln Leu Gly Asn His Ser Glu Glu Asp Ser 
        755                 760                 765             


Thr Asp Asp Gln Arg Glu Asp Thr Arg Ile Lys Pro Ile Tyr Asn Leu 
    770                 775                 780                 


Tyr Ala Ile Ser Cys His Ser Gly Ile Leu Gly Gly Gly His Tyr Val 
785                 790                 795                 800 


Thr Tyr Ala Lys Asn Pro Asn Cys Lys Trp Tyr Cys Tyr Asn Asp Ser 
                805                 810                 815     


Ser Cys Lys Glu Leu His Pro Asp Glu Ile Asp Thr Asp Ser Ala Tyr 
            820                 825                 830         


Ile Leu Phe Tyr Glu Gln Gln Gly Ile Asp Tyr Ala Gln Phe Leu Pro 
        835                 840                 845             


Lys Thr Asp Gly Lys Lys Met Ala Asp Thr Ser Ser Met Asp Glu Asp 
    850                 855                 860                 


Phe Glu Ser Asp Tyr Lys Lys Tyr Cys Val Leu Gln 
865                 870                 875     


<210> 129
<211> 300
<212> PRT
<213> Homo sapiens

<400> 129
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 130
<211> 313
<212> PRT
<213> Homo sapiens

<400> 130
Arg Val Gly Ala Gly Leu Gln Asn Leu Gly Asn Thr Cys Phe Ala Asn 
1               5                   10                  15      


Ala Ala Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser His Glu His Ser Lys Thr Cys His Ala Glu Gly Phe Cys Met 
        35                  40                  45              


Met Cys Thr Met Gln Ala His Ile Thr Gln Ala Leu Ser Asn Pro Gly 
    50                  55                  60                  


Asp Val Ile Lys Pro Met Phe Val Ile Asn Glu Met Arg Arg Ile Ala 
65                  70                  75                  80  


Arg His Phe Arg Phe Gly Asn Gln Glu Asp Ala His Glu Phe Leu Gln 
                85                  90                  95      


Tyr Thr Val Asp Ala Met Gln Lys Ala Cys Leu Asn Gly Ser Asn Lys 
            100                 105                 110         


Leu Asp Arg His Thr Gln Ala Thr Thr Leu Val Cys Gln Ile Phe Gly 
        115                 120                 125             


Gly Tyr Leu Arg Ser Arg Val Lys Cys Leu Asn Cys Lys Gly Val Ser 
    130                 135                 140                 


Asp Thr Phe Asp Pro Tyr Leu Asp Ile Thr Leu Glu Ile Lys Ala Ala 
145                 150                 155                 160 


Gln Ser Val Asn Lys Ala Leu Glu Gln Phe Val Lys Pro Glu Gln Leu 
                165                 170                 175     


Asp Gly Glu Asn Ser Tyr Lys Cys Ser Lys Cys Lys Lys Met Val Pro 
            180                 185                 190         


Ala Ser Lys Arg Phe Thr Ile His Arg Ser Ser Asn Val Leu Thr Leu 
        195                 200                 205             


Ser Leu Lys Arg Phe Ala Asn Phe Thr Gly Gly Lys Ile Ala Lys Asp 
    210                 215                 220                 


Val Lys Tyr Pro Glu Tyr Leu Asp Ile Arg Pro Tyr Met Ser Gln Pro 
225                 230                 235                 240 


Asn Gly Glu Pro Ile Val Tyr Val Leu Tyr Ala Val Leu Val His Thr 
                245                 250                 255     


Gly Phe Asn Cys His Ala Gly His Tyr Phe Cys Tyr Ile Lys Ala Ser 
            260                 265                 270         


Asn Gly Leu Trp Tyr Gln Met Asn Asp Ser Ile Val Ser Thr Ser Asp 
        275                 280                 285             


Ile Arg Ser Val Leu Ser Gln Gln Ala Tyr Val Leu Phe Tyr Ile Arg 
    290                 295                 300                 


Ser His Asp Val Lys Asn Gly Gly Glu 
305                 310             


<210> 131
<211> 344
<212> PRT
<213> Homo sapiens

<400> 131
Ala Val Gly Ala Gly Leu Gln Lys Ile Gly Asn Thr Phe Tyr Val Asn 
1               5                   10                  15      


Val Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ser Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu Asp Ser Gln Thr Cys His Leu His Lys Cys Cys Met 
        35                  40                  45              


Phe Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Val Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Glu Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Leu Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Ala Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Tyr Leu His Cys His Gly Val Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Lys Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Lys Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu Pro Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Lys Cys 
    210                 215                 220                 


Arg Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Gly Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Pro Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Val Pro Glu Leu 
            340                 


<210> 132
<211> 344
<212> PRT
<213> Homo sapiens

<400> 132
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 133
<211> 533
<212> PRT
<213> Homo sapiens

<400> 133
Tyr Gly Pro Gly Tyr Thr Gly Leu Lys Asn Leu Gly Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Ser Ser Val Met Gln Ala Ile Phe Ser Ile Pro Glu Phe Gln Arg 
            20                  25                  30          


Ala Tyr Val Gly Asn Leu Pro Arg Ile Phe Asp Tyr Ser Pro Leu Asp 
        35                  40                  45              


Pro Thr Gln Asp Phe Asn Thr Gln Met Thr Lys Leu Gly His Gly Leu 
    50                  55                  60                  


Leu Ser Gly Gln Tyr Ser Lys Pro Pro Val Lys Ser Glu Leu Ile Glu 
65                  70                  75                  80  


Gln Val Met Lys Glu Glu His Lys Pro Gln Gln Asn Gly Ile Ser Pro 
                85                  90                  95      


Arg Met Phe Lys Ala Phe Val Ser Lys Ser His Pro Glu Phe Ser Ser 
            100                 105                 110         


Asn Arg Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Val Asn Leu 
        115                 120                 125             


Val Glu Arg Asn Arg Ile Gly Ser Glu Asn Pro Ser Asp Val Phe Arg 
    130                 135                 140                 


Phe Leu Val Glu Glu Arg Ile Gln Cys Cys Gln Thr Arg Lys Val Arg 
145                 150                 155                 160 


Tyr Thr Glu Arg Val Asp Tyr Leu Met Gln Leu Pro Val Ala Met Glu 
                165                 170                 175     


Ala Ala Thr Asn Lys Asp Glu Leu Ile Ala Tyr Glu Leu Thr Arg Arg 
            180                 185                 190         


Glu Ala Glu Ala Asn Arg Arg Pro Leu Pro Glu Leu Val Arg Ala Lys 
        195                 200                 205             


Ile Pro Phe Ser Ala Cys Leu Gln Ala Phe Ser Glu Pro Glu Asn Val 
    210                 215                 220                 


Asp Asp Phe Trp Ser Ser Ala Leu Gln Ala Lys Ser Ala Gly Val Lys 
225                 230                 235                 240 


Thr Ser Arg Phe Ala Ser Phe Pro Glu Tyr Leu Val Val Gln Ile Lys 
                245                 250                 255     


Lys Phe Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Phe Asp Val Ser 
            260                 265                 270         


Ile Asp Met Pro Asp Leu Leu Asp Ile Asn His Leu Arg Ala Arg Gly 
        275                 280                 285             


Leu Gln Pro Gly Glu Glu Glu Leu Pro Asp Ile Ser Pro Pro Ile Val 
    290                 295                 300                 


Ile Pro Asp Asp Ser Lys Asp Arg Leu Met Asn Gln Leu Ile Asp Pro 
305                 310                 315                 320 


Ser Asp Ile Asp Glu Ser Ser Val Met Gln Leu Ala Glu Met Gly Phe 
                325                 330                 335     


Pro Leu Glu Ala Cys Arg Lys Ala Val Tyr Phe Thr Gly Asn Met Gly 
            340                 345                 350         


Ala Glu Val Ala Phe Asn Trp Ile Ile Val His Met Glu Glu Pro Asp 
        355                 360                 365             


Phe Ala Glu Pro Leu Thr Met Pro Gly Tyr Gly Gly Ala Ala Ser Ala 
    370                 375                 380                 


Gly Ala Ser Val Phe Gly Ala Ser Gly Leu Asp Asn Gln Pro Pro Glu 
385                 390                 395                 400 


Glu Ile Val Ala Ile Ile Thr Ser Met Gly Phe Gln Arg Asn Gln Ala 
                405                 410                 415     


Ile Gln Ala Leu Arg Ala Thr Asn Asn Asn Leu Glu Arg Ala Leu Asp 
            420                 425                 430         


Trp Ile Phe Ser His Pro Glu Phe Glu Glu Asp Ser Asp Phe Val Ile 
        435                 440                 445             


Glu Met Glu Asn Asn Ala Asn Ala Asn Ile Ile Ser Glu Ala Lys Pro 
    450                 455                 460                 


Glu Gly Pro Arg Val Lys Asp Gly Ser Gly Thr Tyr Glu Leu Phe Ala 
465                 470                 475                 480 


Phe Ile Ser His Met Gly Thr Ser Thr Met Ser Gly His Tyr Ile Cys 
                485                 490                 495     


His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr Asn Asp His Lys Val 
            500                 505                 510         


Cys Ala Ser Glu Arg Pro Pro Lys Asp Leu Gly Tyr Met Tyr Phe Tyr 
        515                 520                 525             


Arg Arg Ile Pro Ser 
    530             


<210> 134
<211> 629
<212> PRT
<213> Homo sapiens

<400> 134
Lys Gly Gln Pro Gly Ile Cys Gly Leu Thr Asn Leu Gly Asn Thr Cys 
1               5                   10                  15      


Phe Met Asn Ser Ala Leu Gln Cys Leu Ser Asn Val Pro Gln Leu Thr 
            20                  25                  30          


Glu Tyr Phe Leu Asn Asn Cys Tyr Leu Glu Glu Leu Asn Phe Arg Asn 
        35                  40                  45              


Pro Leu Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Asp Leu Val 
    50                  55                  60                  


Lys Gln Ala Trp Ser Gly His His Arg Ser Ile Val Pro His Val Phe 
65                  70                  75                  80  


Lys Asn Lys Val Gly His Phe Ala Ser Gln Phe Leu Gly Tyr Gln Gln 
                85                  90                  95      


His Asp Ser Gln Glu Leu Leu Ser Phe Leu Leu Asp Gly Leu His Glu 
            100                 105                 110         


Asp Leu Asn Arg Val Lys Lys Lys Glu Tyr Val Glu Leu Cys Asp Ala 
        115                 120                 125             


Ala Gly Arg Pro Asp Gln Glu Val Ala Gln Glu Ala Trp Gln Asn His 
    130                 135                 140                 


Lys Arg Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu Phe 
145                 150                 155                 160 


Lys Ser Thr Leu Val Cys Pro Asp Cys Gly Asn Val Ser Val Thr Phe 
                165                 170                 175     


Asp Pro Phe Cys Tyr Leu Ser Val Pro Leu Pro Ile Ser His Lys Arg 
            180                 185                 190         


Val Leu Glu Val Phe Phe Ile Pro Met Asp Pro Arg Arg Lys Pro Glu 
        195                 200                 205             


Gln His Arg Leu Val Val Pro Lys Lys Gly Lys Ile Ser Asp Leu Cys 
    210                 215                 220                 


Val Ala Leu Ser Lys His Thr Gly Ile Ser Pro Glu Arg Met Met Val 
225                 230                 235                 240 


Ala Asp Val Phe Ser His Arg Phe Tyr Lys Leu Tyr Gln Leu Glu Glu 
                245                 250                 255     


Pro Leu Ser Ser Ile Leu Asp Arg Asp Asp Ile Phe Val Tyr Glu Val 
            260                 265                 270         


Ser Gly Arg Ile Glu Ala Ile Glu Gly Ser Arg Glu Asp Ile Val Val 
        275                 280                 285             


Pro Val Tyr Leu Arg Glu Arg Thr Pro Ala Arg Asp Tyr Asn Asn Ser 
    290                 295                 300                 


Tyr Tyr Gly Leu Met Leu Phe Gly His Pro Leu Leu Val Ser Val Pro 
305                 310                 315                 320 


Arg Asp Arg Phe Thr Trp Glu Gly Leu Tyr Asn Val Leu Met Tyr Arg 
                325                 330                 335     


Leu Ser Arg Tyr Val Thr Lys Pro Asn Ser Asp Asp Glu Asp Asp Gly 
            340                 345                 350         


Asp Glu Lys Glu Asp Asp Glu Glu Asp Lys Asp Asp Val Pro Gly Pro 
        355                 360                 365             


Ser Thr Gly Gly Ser Leu Arg Asp Pro Glu Pro Glu Gln Ala Gly Pro 
    370                 375                 380                 


Ser Ser Gly Val Thr Asn Arg Cys Pro Phe Leu Leu Asp Asn Cys Leu 
385                 390                 395                 400 


Gly Thr Ser Gln Trp Pro Pro Arg Arg Arg Arg Lys Gln Leu Phe Thr 
                405                 410                 415     


Leu Gln Thr Val Asn Ser Asn Gly Thr Ser Asp Arg Thr Thr Ser Pro 
            420                 425                 430         


Glu Glu Val His Ala Gln Pro Tyr Ile Ala Ile Asp Trp Glu Pro Glu 
        435                 440                 445             


Met Lys Lys Arg Tyr Tyr Asp Glu Val Glu Ala Glu Gly Tyr Val Lys 
    450                 455                 460                 


His Asp Cys Val Gly Tyr Val Met Lys Lys Ala Pro Val Arg Leu Gln 
465                 470                 475                 480 


Glu Cys Ile Glu Leu Phe Thr Thr Val Glu Thr Leu Glu Lys Glu Asn 
                485                 490                 495     


Pro Trp Tyr Cys Pro Ser Cys Lys Gln His Gln Leu Ala Thr Lys Lys 
            500                 505                 510         


Leu Asp Leu Trp Met Leu Pro Glu Ile Leu Ile Ile His Leu Lys Arg 
        515                 520                 525             


Phe Ser Tyr Thr Lys Phe Ser Arg Glu Lys Leu Asp Thr Leu Val Glu 
    530                 535                 540                 


Phe Pro Ile Arg Asp Leu Asp Phe Ser Glu Phe Val Ile Gln Pro Gln 
545                 550                 555                 560 


Asn Glu Ser Asn Pro Glu Leu Tyr Lys Tyr Asp Leu Ile Ala Val Ser 
                565                 570                 575     


Asn His Tyr Gly Gly Met Arg Asp Gly His Tyr Thr Thr Phe Ala Cys 
            580                 585                 590         


Asn Lys Asp Ser Gly Gln Trp His Tyr Phe Asp Asp Asn Ser Val Ser 
        595                 600                 605             


Pro Val Asn Glu Asn Gln Ile Glu Ser Lys Ala Ala Tyr Val Leu Phe 
    610                 615                 620                 


Tyr Gln Arg Gln Asp 
625                 


<210> 135
<211> 300
<212> PRT
<213> Homo sapiens

<400> 135
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Cys Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Val Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Ile Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 136
<211> 387
<212> PRT
<213> Homo sapiens

<400> 136
Ala Ser Ala Met Glu Leu Pro Cys Gly Leu Thr Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Tyr Met Asn Ala Thr Val Gln Cys Ile Arg Ser Val Pro Glu Leu 
            20                  25                  30          


Lys Asp Ala Leu Lys Arg Tyr Ala Gly Ala Leu Arg Ala Ser Gly Glu 
        35                  40                  45              


Met Ala Ser Ala Gln Tyr Ile Thr Ala Ala Leu Arg Asp Leu Phe Asp 
    50                  55                  60                  


Ser Met Asp Lys Thr Ser Ser Ser Ile Pro Pro Ile Ile Leu Leu Gln 
65                  70                  75                  80  


Phe Leu His Met Ala Phe Pro Gln Phe Ala Glu Lys Gly Glu Gln Gly 
                85                  90                  95      


Gln Tyr Leu Gln Gln Asp Ala Asn Glu Cys Trp Ile Gln Met Met Arg 
            100                 105                 110         


Val Leu Gln Gln Lys Leu Glu Ala Ile Glu Asp Asp Ser Val Lys Glu 
        115                 120                 125             


Thr Asp Ser Ser Ser Ala Ser Ala Ala Thr Pro Ser Lys Lys Lys Ser 
    130                 135                 140                 


Leu Ile Asp Gln Phe Phe Gly Val Glu Phe Glu Thr Thr Met Lys Cys 
145                 150                 155                 160 


Thr Glu Ser Glu Glu Glu Glu Val Thr Lys Gly Lys Glu Asn Gln Leu 
                165                 170                 175     


Gln Leu Ser Cys Phe Ile Asn Gln Glu Val Lys Tyr Leu Phe Thr Gly 
            180                 185                 190         


Leu Lys Leu Arg Leu Gln Glu Glu Ile Thr Lys Gln Ser Pro Thr Leu 
        195                 200                 205             


Gln Arg Asn Ala Leu Tyr Ile Lys Ser Ser Lys Ile Ser Arg Leu Pro 
    210                 215                 220                 


Ala Tyr Leu Thr Ile Gln Met Val Arg Phe Phe Tyr Lys Glu Lys Glu 
225                 230                 235                 240 


Ser Val Asn Ala Lys Val Leu Lys Asp Val Lys Phe Pro Leu Met Leu 
                245                 250                 255     


Asp Met Tyr Glu Leu Cys Thr Pro Glu Leu Gln Glu Lys Met Val Ser 
            260                 265                 270         


Phe Arg Ser Lys Phe Lys Asp Leu Glu Asp Lys Lys Val Asn Gln Gln 
        275                 280                 285             


Pro Asn Thr Ser Asp Lys Lys Ser Ser Pro Gln Lys Glu Val Lys Tyr 
    290                 295                 300                 


Glu Pro Phe Ser Phe Ala Asp Asp Ile Gly Ser Asn Asn Cys Gly Tyr 
305                 310                 315                 320 


Tyr Asp Leu Gln Ala Val Leu Thr His Gln Gly Arg Ser Ser Ser Ser 
                325                 330                 335     


Gly His Tyr Val Ser Trp Val Lys Arg Lys Gln Asp Glu Trp Ile Lys 
            340                 345                 350         


Phe Asp Asp Asp Lys Val Ser Ile Val Thr Pro Glu Asp Ile Leu Arg 
        355                 360                 365             


Leu Ser Gly Gly Gly Asp Trp His Ile Ala Tyr Val Leu Leu Tyr Gly 
    370                 375                 380                 


Pro Arg Arg 
385         


<210> 137
<211> 630
<212> PRT
<213> Homo sapiens

<400> 137
Ser His Ile Gln Pro Gly Leu Cys Gly Leu Gly Asn Leu Gly Asn Thr 
1               5                   10                  15      


Cys Phe Met Asn Ser Ala Leu Gln Cys Leu Ser Asn Thr Ala Pro Leu 
            20                  25                  30          


Thr Asp Tyr Phe Leu Lys Asp Glu Tyr Glu Ala Glu Ile Asn Arg Asp 
        35                  40                  45              


Asn Pro Leu Gly Met Lys Gly Glu Ile Ala Glu Ala Tyr Ala Glu Leu 
    50                  55                  60                  


Ile Lys Gln Met Trp Ser Gly Arg Asp Ala His Val Ala Pro Arg Met 
65                  70                  75                  80  


Phe Lys Thr Gln Val Gly Arg Phe Ala Pro Gln Phe Ser Gly Tyr Gln 
                85                  90                  95      


Gln Gln Asp Ser Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His 
            100                 105                 110         


Glu Asp Leu Asn Arg Val Lys Lys Lys Pro Tyr Leu Glu Leu Lys Asp 
        115                 120                 125             


Ala Asn Gly Arg Pro Asp Ala Val Val Ala Lys Glu Ala Trp Glu Asn 
    130                 135                 140                 


His Arg Leu Arg Asn Asp Ser Val Ile Val Asp Thr Phe His Gly Leu 
145                 150                 155                 160 


Phe Lys Ser Thr Leu Val Cys Pro Glu Cys Ala Lys Val Ser Val Thr 
                165                 170                 175     


Phe Asp Pro Phe Cys Tyr Leu Thr Leu Pro Leu Pro Leu Lys Lys Asp 
            180                 185                 190         


Arg Val Met Glu Val Phe Leu Val Pro Ala Asp Pro His Cys Arg Pro 
        195                 200                 205             


Thr Gln Tyr Arg Val Thr Val Pro Leu Met Gly Ala Val Ser Asp Leu 
    210                 215                 220                 


Cys Glu Ala Leu Ser Arg Leu Ser Gly Ile Ala Ala Glu Asn Met Val 
225                 230                 235                 240 


Val Ala Asp Val Tyr Asn His Arg Phe His Lys Ile Phe Gln Met Asp 
                245                 250                 255     


Glu Gly Leu Asn His Ile Met Pro Arg Asp Asp Ile Phe Val Tyr Glu 
            260                 265                 270         


Val Cys Ser Thr Ser Val Asp Gly Ser Glu Cys Val Thr Leu Pro Val 
        275                 280                 285             


Tyr Phe Arg Glu Arg Lys Ser Arg Pro Ser Ser Thr Ser Ser Ala Ser 
    290                 295                 300                 


Ala Leu Tyr Gly Gln Pro Leu Leu Leu Ser Val Pro Lys His Lys Leu 
305                 310                 315                 320 


Thr Leu Glu Ser Leu Tyr Gln Ala Val Cys Asp Arg Ile Ser Arg Tyr 
                325                 330                 335     


Val Lys Gln Pro Leu Pro Asp Glu Phe Gly Ser Ser Pro Leu Glu Pro 
            340                 345                 350         


Gly Ala Cys Asn Gly Ser Arg Asn Ser Cys Glu Gly Glu Asp Glu Glu 
        355                 360                 365             


Glu Met Glu His Gln Glu Glu Gly Lys Glu Gln Leu Ser Glu Thr Glu 
    370                 375                 380                 


Gly Ser Gly Glu Asp Glu Pro Gly Asn Asp Pro Ser Glu Thr Thr Gln 
385                 390                 395                 400 


Lys Lys Ile Lys Gly Gln Pro Cys Pro Lys Arg Leu Phe Thr Phe Ser 
                405                 410                 415     


Leu Val Asn Ser Tyr Gly Thr Ala Asp Ile Asn Ser Leu Ala Ala Asp 
            420                 425                 430         


Gly Lys Leu Leu Lys Leu Asn Ser Arg Ser Thr Leu Ala Met Asp Trp 
        435                 440                 445             


Asp Ser Glu Thr Arg Arg Leu Tyr Tyr Asp Glu Gln Glu Ser Glu Ala 
    450                 455                 460                 


Tyr Glu Lys His Val Ser Met Leu Gln Pro Gln Lys Lys Lys Lys Thr 
465                 470                 475                 480 


Thr Val Ala Leu Arg Asp Cys Ile Glu Leu Phe Thr Thr Met Glu Thr 
                485                 490                 495     


Leu Gly Glu His Asp Pro Trp Tyr Cys Pro Asn Cys Lys Lys His Gln 
            500                 505                 510         


Gln Ala Thr Lys Lys Phe Asp Leu Trp Ser Leu Pro Lys Ile Leu Val 
        515                 520                 525             


Val His Leu Lys Arg Phe Ser Tyr Asn Arg Tyr Trp Arg Asp Lys Leu 
    530                 535                 540                 


Asp Thr Val Val Glu Phe Pro Ile Arg Gly Leu Asn Met Ser Glu Phe 
545                 550                 555                 560 


Val Cys Asn Leu Ser Ala Arg Pro Tyr Val Tyr Asp Leu Ile Ala Val 
                565                 570                 575     


Ser Asn His Tyr Gly Ala Met Gly Val Gly His Tyr Thr Ala Tyr Ala 
            580                 585                 590         


Lys Asn Lys Leu Asn Gly Lys Trp Tyr Tyr Phe Asp Asp Ser Asn Val 
        595                 600                 605             


Ser Leu Ala Ser Glu Asp Gln Ile Val Thr Lys Ala Ala Tyr Val Leu 
    610                 615                 620                 


Phe Tyr Gln Arg Arg Asp 
625                 630 


<210> 138
<211> 595
<212> PRT
<213> Homo sapiens

<400> 138
Lys Ile Cys His Gly Leu Pro Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Val Leu Gln Ser Leu Leu Ser Ile Pro Ser Phe Ala Asp Asp Leu 
            20                  25                  30          


Leu Asn Gln Ser Phe Pro Trp Gly Lys Ile Pro Leu Asn Ala Leu Thr 
        35                  40                  45              


Met Cys Leu Ala Arg Leu Leu Phe Phe Lys Asp Thr Tyr Asn Ile Glu 
    50                  55                  60                  


Ile Lys Glu Met Leu Leu Leu Asn Leu Lys Lys Ala Ile Ser Ala Ala 
65                  70                  75                  80  


Ala Glu Ile Phe His Gly Asn Ala Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Ala His Cys Leu Asp Gln Leu Lys Asp Asn Met Glu Lys Leu Asn Thr 
            100                 105                 110         


Ile Trp Lys Pro Lys Ser Glu Phe Gly Glu Asp Asn Phe Pro Lys Gln 
        115                 120                 125             


Val Phe Ala Asp Asp Pro Asp Thr Ser Gly Phe Ser Cys Pro Val Ile 
    130                 135                 140                 


Thr Asn Phe Glu Leu Glu Leu Leu His Ser Ile Ala Cys Lys Ala Cys 
145                 150                 155                 160 


Gly Gln Val Ile Leu Lys Thr Glu Leu Asn Asn Tyr Leu Ser Ile Asn 
                165                 170                 175     


Leu Pro Gln Arg Ile Lys Ala His Pro Ser Ser Ile Gln Ser Thr Phe 
            180                 185                 190         


Asp Leu Phe Phe Gly Ala Glu Glu Leu Glu Tyr Lys Cys Ala Lys Cys 
        195                 200                 205             


Glu His Lys Thr Ser Val Gly Val His Ser Phe Ser Arg Leu Pro Arg 
    210                 215                 220                 


Ile Leu Ile Val His Leu Lys Arg Tyr Ser Leu Asn Glu Phe Cys Ala 
225                 230                 235                 240 


Leu Lys Lys Asn Asp Gln Glu Val Ile Ile Ser Lys Tyr Leu Lys Val 
                245                 250                 255     


Ser Ser His Cys Asn Glu Gly Thr Arg Pro Pro Leu Pro Leu Ser Glu 
            260                 265                 270         


Asp Gly Glu Ile Thr Asp Phe Gln Leu Leu Lys Val Ile Arg Lys Met 
        275                 280                 285             


Thr Ser Gly Asn Ile Ser Val Ser Trp Pro Ala Thr Lys Glu Ser Lys 
    290                 295                 300                 


Asp Ile Leu Ala Pro His Ile Gly Ser Asp Lys Glu Ser Glu Gln Lys 
305                 310                 315                 320 


Lys Gly Gln Thr Val Phe Lys Gly Ala Ser Arg Arg Gln Gln Gln Lys 
                325                 330                 335     


Tyr Leu Gly Lys Asn Ser Lys Pro Asn Glu Leu Glu Ser Val Tyr Ser 
            340                 345                 350         


Gly Asp Arg Ala Phe Ile Glu Lys Glu Pro Leu Ala His Leu Met Thr 
        355                 360                 365             


Tyr Leu Glu Asp Thr Ser Leu Cys Gln Phe His Lys Ala Gly Gly Lys 
    370                 375                 380                 


Pro Ala Ser Ser Pro Gly Thr Pro Leu Ser Lys Val Asp Phe Gln Thr 
385                 390                 395                 400 


Val Pro Glu Asn Pro Lys Arg Lys Lys Tyr Val Lys Thr Ser Lys Phe 
                405                 410                 415     


Val Ala Phe Asp Arg Ile Ile Asn Pro Thr Lys Asp Leu Tyr Glu Asp 
            420                 425                 430         


Lys Asn Ile Arg Ile Pro Glu Arg Phe Gln Lys Val Ser Glu Gln Thr 
        435                 440                 445             


Gln Gln Cys Asp Gly Met Arg Ile Cys Glu Gln Ala Pro Gln Gln Ala 
    450                 455                 460                 


Leu Pro Gln Ser Phe Pro Lys Pro Gly Thr Gln Gly His Thr Lys Asn 
465                 470                 475                 480 


Leu Leu Arg Pro Thr Lys Leu Asn Leu Gln Lys Ser Asn Arg Asn Ser 
                485                 490                 495     


Leu Leu Ala Leu Gly Ser Asn Lys Asn Pro Arg Asn Lys Asp Ile Leu 
            500                 505                 510         


Asp Lys Ile Lys Ser Lys Ala Lys Glu Thr Lys Arg Asn Asp Asp Lys 
        515                 520                 525             


Gly Asp His Thr Tyr Arg Leu Ile Ser Val Val Ser His Leu Gly Lys 
    530                 535                 540                 


Thr Leu Lys Ser Gly His Tyr Ile Cys Asp Ala Tyr Asp Phe Glu Lys 
545                 550                 555                 560 


Gln Ile Trp Phe Thr Tyr Asp Asp Met Arg Val Leu Gly Ile Gln Glu 
                565                 570                 575     


Ala Gln Met Gln Glu Asp Arg Arg Cys Thr Gly Tyr Ile Phe Phe Tyr 
            580                 585                 590         


Met His Asn 
        595 


<210> 139
<211> 723
<212> PRT
<213> Homo sapiens

<400> 139
Leu Pro Gly Phe Thr Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Val Ile Gln Ser Leu Ser Asn Thr Arg Glu Leu Arg Asp Phe 
            20                  25                  30          


Phe His Asp Arg Ser Phe Glu Ala Glu Ile Asn Tyr Asn Asn Pro Leu 
        35                  40                  45              


Gly Thr Gly Gly Arg Leu Ala Ile Gly Phe Ala Val Leu Leu Arg Ala 
    50                  55                  60                  


Leu Trp Lys Gly Thr His His Ala Phe Gln Pro Ser Lys Leu Lys Ala 
65                  70                  75                  80  


Ile Val Ala Ser Lys Ala Ser Gln Phe Thr Gly Tyr Ala Gln His Asp 
                85                  90                  95      


Ala Gln Glu Phe Met Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu 
            100                 105                 110         


Asn Arg Ile Gln Asn Lys Pro Tyr Thr Glu Thr Val Asp Ser Asp Gly 
        115                 120                 125             


Arg Pro Asp Glu Val Val Ala Glu Glu Ala Trp Gln Arg His Lys Met 
    130                 135                 140                 


Arg Asn Asp Ser Phe Ile Val Asp Leu Phe Gln Gly Gln Tyr Lys Ser 
145                 150                 155                 160 


Lys Leu Val Cys Pro Val Cys Ala Lys Val Ser Ile Thr Phe Asp Pro 
                165                 170                 175     


Phe Leu Tyr Leu Pro Val Pro Leu Pro Gln Lys Gln Lys Val Leu Pro 
            180                 185                 190         


Val Phe Tyr Phe Ala Arg Glu Pro His Ser Lys Pro Ile Lys Phe Leu 
        195                 200                 205             


Val Ser Val Ser Lys Glu Asn Ser Thr Ala Ser Glu Val Leu Asp Ser 
    210                 215                 220                 


Leu Ser Gln Ser Val His Val Lys Pro Glu Asn Leu Arg Leu Ala Glu 
225                 230                 235                 240 


Val Ile Lys Asn Arg Phe His Arg Val Phe Leu Pro Ser His Ser Leu 
                245                 250                 255     


Asp Thr Val Ser Pro Ser Asp Thr Leu Leu Cys Phe Glu Leu Leu Ser 
            260                 265                 270         


Ser Glu Leu Ala Lys Glu Arg Val Val Val Leu Glu Val Gln Gln Arg 
        275                 280                 285             


Pro Gln Val Pro Ser Val Pro Ile Ser Lys Cys Ala Ala Cys Gln Arg 
    290                 295                 300                 


Lys Gln Gln Ser Glu Asp Glu Lys Leu Lys Arg Cys Thr Arg Cys Tyr 
305                 310                 315                 320 


Arg Val Gly Tyr Cys Asn Gln Leu Cys Gln Lys Thr His Trp Pro Asp 
                325                 330                 335     


His Lys Gly Leu Cys Arg Pro Glu Asn Ile Gly Tyr Pro Phe Leu Val 
            340                 345                 350         


Ser Val Pro Ala Ser Arg Leu Thr Tyr Ala Arg Leu Ala Gln Leu Leu 
        355                 360                 365             


Glu Gly Tyr Ala Arg Tyr Ser Val Ser Val Phe Gln Pro Pro Phe Gln 
    370                 375                 380                 


Pro Gly Arg Met Ala Leu Glu Ser Gln Ser Pro Gly Cys Thr Thr Leu 
385                 390                 395                 400 


Leu Ser Thr Gly Ser Leu Glu Ala Gly Asp Ser Glu Arg Asp Pro Ile 
                405                 410                 415     


Gln Pro Pro Glu Leu Gln Leu Val Thr Pro Met Ala Glu Gly Asp Thr 
            420                 425                 430         


Gly Leu Pro Arg Val Trp Ala Ala Pro Asp Arg Gly Pro Val Pro Ser 
        435                 440                 445             


Thr Ser Gly Ile Ser Ser Glu Met Leu Ala Ser Gly Pro Ile Glu Val 
    450                 455                 460                 


Gly Ser Leu Pro Ala Gly Glu Arg Val Ser Arg Pro Glu Ala Ala Val 
465                 470                 475                 480 


Pro Gly Tyr Gln His Pro Ser Glu Ala Met Asn Ala His Thr Pro Gln 
                485                 490                 495     


Phe Phe Ile Tyr Lys Ile Asp Ser Ser Asn Arg Glu Gln Arg Leu Glu 
            500                 505                 510         


Asp Lys Gly Asp Thr Pro Leu Glu Leu Gly Asp Asp Cys Ser Leu Ala 
        515                 520                 525             


Leu Val Trp Arg Asn Asn Glu Arg Leu Gln Glu Phe Val Leu Val Ala 
    530                 535                 540                 


Ser Lys Glu Leu Glu Cys Ala Glu Asp Pro Gly Ser Ala Gly Glu Ala 
545                 550                 555                 560 


Ala Arg Ala Gly His Phe Thr Leu Asp Gln Cys Leu Asn Leu Phe Thr 
                565                 570                 575     


Arg Pro Glu Val Leu Ala Pro Glu Glu Ala Trp Tyr Cys Pro Gln Cys 
            580                 585                 590         


Lys Gln His Arg Glu Ala Ser Lys Gln Leu Leu Leu Trp Arg Leu Pro 
        595                 600                 605             


Asn Val Leu Ile Val Gln Leu Lys Arg Phe Ser Phe Arg Ser Phe Ile 
    610                 615                 620                 


Trp Arg Asp Lys Ile Asn Asp Leu Val Glu Phe Pro Val Arg Asn Leu 
625                 630                 635                 640 


Asp Leu Ser Lys Phe Cys Ile Gly Gln Lys Glu Glu Gln Leu Pro Ser 
                645                 650                 655     


Tyr Asp Leu Tyr Ala Val Ile Asn His Tyr Gly Gly Met Ile Gly Gly 
            660                 665                 670         


His Tyr Thr Ala Cys Ala Arg Leu Pro Asn Asp Arg Ser Ser Gln Arg 
        675                 680                 685             


Ser Asp Val Gly Trp Arg Leu Phe Asp Asp Ser Thr Val Thr Thr Val 
    690                 695                 700                 


Asp Glu Ser Gln Val Val Thr Arg Tyr Ala Tyr Val Leu Phe Tyr Arg 
705                 710                 715                 720 


Arg Arg Asn 
            


<210> 140
<211> 386
<212> PRT
<213> Homo sapiens

<400> 140
Ser Leu Gln Pro Arg Gly Leu Ile Asn Lys Gly Asn Trp Cys Tyr Ile 
1               5                   10                  15      


Asn Ala Thr Leu Gln Ala Leu Val Ala Cys Pro Pro Met Tyr His Leu 
            20                  25                  30          


Met Lys Phe Ile Pro Leu Tyr Ser Lys Val Gln Arg Pro Cys Thr Ser 
        35                  40                  45              


Thr Pro Met Ile Asp Ser Phe Val Arg Leu Met Asn Glu Phe Thr Asn 
    50                  55                  60                  


Met Pro Val Pro Pro Lys Pro Arg Gln Ala Leu Gly Asp Lys Ile Val 
65                  70                  75                  80  


Arg Asp Ile Arg Pro Gly Ala Ala Phe Glu Pro Thr Tyr Ile Tyr Arg 
                85                  90                  95      


Leu Leu Thr Val Asn Lys Ser Ser Leu Ser Glu Lys Gly Arg Gln Glu 
            100                 105                 110         


Asp Ala Glu Glu Tyr Leu Gly Phe Ile Leu Asn Gly Leu His Glu Glu 
        115                 120                 125             


Met Leu Asn Leu Lys Lys Leu Leu Ser Pro Ser Asn Glu Lys Leu Thr 
    130                 135                 140                 


Ile Ser Asn Gly Pro Lys Asn His Ser Val Asn Glu Glu Glu Gln Glu 
145                 150                 155                 160 


Glu Gln Gly Glu Gly Ser Glu Asp Glu Trp Glu Gln Val Gly Pro Arg 
                165                 170                 175     


Asn Lys Thr Ser Val Thr Arg Gln Ala Asp Phe Val Gln Thr Pro Ile 
            180                 185                 190         


Thr Gly Ile Phe Gly Gly His Ile Arg Ser Val Val Tyr Gln Gln Ser 
        195                 200                 205             


Ser Lys Glu Ser Ala Thr Leu Gln Pro Phe Phe Thr Leu Gln Leu Asp 
    210                 215                 220                 


Ile Gln Ser Asp Lys Ile Arg Thr Val Gln Asp Ala Leu Glu Ser Leu 
225                 230                 235                 240 


Val Ala Arg Glu Ser Val Gln Gly Tyr Thr Thr Lys Thr Lys Gln Glu 
                245                 250                 255     


Val Glu Ile Ser Arg Arg Val Thr Leu Glu Lys Leu Pro Pro Val Leu 
            260                 265                 270         


Val Leu His Leu Lys Arg Phe Val Tyr Glu Lys Thr Gly Gly Cys Gln 
        275                 280                 285             


Lys Leu Ile Lys Asn Ile Glu Tyr Pro Val Asp Leu Glu Ile Ser Lys 
    290                 295                 300                 


Glu Leu Leu Ser Pro Gly Val Lys Asn Lys Asn Phe Lys Cys His Arg 
305                 310                 315                 320 


Thr Tyr Arg Leu Phe Ala Val Val Tyr His His Gly Asn Ser Ala Thr 
                325                 330                 335     


Gly Gly His Tyr Thr Thr Asp Val Phe Gln Ile Gly Leu Asn Gly Trp 
            340                 345                 350         


Leu Arg Ile Asp Asp Gln Thr Val Lys Val Ile Asn Gln Tyr Gln Val 
        355                 360                 365             


Val Lys Pro Thr Ala Glu Arg Thr Ala Tyr Leu Leu Tyr Tyr Arg Arg 
    370                 375                 380                 


Val Asp 
385     


<210> 141
<211> 658
<212> PRT
<213> Homo sapiens

<400> 141
Met Asp Arg Cys Lys His Val Gly Arg Leu Arg Leu Ala Gln Asp His 
1               5                   10                  15      


Ser Ile Leu Asn Pro Gln Lys Trp Cys Cys Leu Glu Cys Ala Thr Thr 
            20                  25                  30          


Glu Ser Val Trp Ala Cys Leu Lys Cys Ser His Val Ala Cys Gly Arg 
        35                  40                  45              


Tyr Ile Glu Asp His Ala Leu Lys His Phe Glu Glu Thr Gly His Pro 
    50                  55                  60                  


Leu Ala Met Glu Val Arg Asp Leu Tyr Val Phe Cys Tyr Leu Cys Lys 
65                  70                  75                  80  


Asp Tyr Val Leu Asn Asp Asn Pro Glu Gly Asp Leu Lys Leu Leu Arg 
                85                  90                  95      


Ser Ser Leu Leu Ala Val Arg Gly Gln Lys Gln Asp Thr Pro Val Arg 
            100                 105                 110         


Arg Gly Arg Thr Leu Arg Ser Met Ala Ser Gly Glu Asp Val Val Leu 
        115                 120                 125             


Pro Gln Arg Ala Pro Gln Gly Gln Pro Gln Met Leu Thr Ala Leu Trp 
    130                 135                 140                 


Tyr Arg Arg Gln Arg Leu Leu Ala Arg Thr Leu Arg Leu Trp Phe Glu 
145                 150                 155                 160 


Lys Ser Ser Arg Gly Gln Ala Lys Leu Glu Gln Arg Arg Gln Glu Glu 
                165                 170                 175     


Ala Leu Glu Arg Lys Lys Glu Glu Ala Arg Arg Arg Arg Arg Glu Val 
            180                 185                 190         


Lys Arg Arg Leu Leu Glu Glu Leu Ala Ser Thr Pro Pro Arg Lys Ser 
        195                 200                 205             


Ala Arg Leu Leu Leu His Thr Pro Arg Asp Ala Gly Pro Ala Ala Ser 
    210                 215                 220                 


Arg Pro Ala Ala Leu Pro Thr Ser Arg Arg Val Pro Ala Ala Thr Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Gln Pro Ala Met Ala Pro Gly Val Thr Gly Leu Arg 
                245                 250                 255     


Asn Leu Gly Asn Thr Cys Tyr Met Asn Ser Ile Leu Gln Val Leu Ser 
            260                 265                 270         


His Leu Gln Lys Phe Arg Glu Cys Phe Leu Asn Leu Asp Pro Ser Lys 
        275                 280                 285             


Thr Glu His Leu Phe Pro Lys Ala Thr Asn Gly Lys Thr Gln Leu Ser 
    290                 295                 300                 


Gly Lys Pro Thr Asn Ser Ser Ala Thr Glu Leu Ser Leu Arg Asn Asp 
305                 310                 315                 320 


Arg Ala Glu Ala Cys Glu Arg Glu Gly Phe Cys Trp Asn Gly Arg Ala 
                325                 330                 335     


Ser Ile Ser Arg Ser Leu Glu Leu Ile Gln Asn Lys Glu Pro Ser Ser 
            340                 345                 350         


Lys His Ile Ser Leu Cys Arg Glu Leu His Thr Leu Phe Arg Val Met 
        355                 360                 365             


Trp Ser Gly Lys Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser 
    370                 375                 380                 


Val Trp Ser Leu Ile Pro Ala Phe Arg Gly Tyr Asp Gln Gln Asp Ala 
385                 390                 395                 400 


Gln Glu Phe Leu Cys Glu Leu Leu His Lys Val Gln Gln Glu Leu Glu 
                405                 410                 415     


Ser Glu Gly Thr Thr Arg Arg Ile Leu Ile Pro Phe Ser Gln Arg Lys 
            420                 425                 430         


Leu Thr Lys Gln Val Leu Lys Val Val Asn Thr Ile Phe His Gly Gln 
        435                 440                 445             


Leu Leu Ser Gln Val Thr Cys Ile Ser Cys Asn Tyr Lys Ser Asn Thr 
    450                 455                 460                 


Ile Glu Pro Phe Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr His 
465                 470                 475                 480 


Cys Ile Glu Lys Gly Phe Val Pro Leu Asn Gln Thr Glu Cys Leu Leu 
                485                 490                 495     


Thr Glu Met Leu Ala Lys Phe Thr Glu Thr Glu Ala Leu Glu Gly Arg 
            500                 505                 510         


Ile Tyr Ala Cys Asp Gln Cys Asn Ser Lys Arg Arg Lys Ser Asn Pro 
        515                 520                 525             


Lys Pro Leu Val Leu Ser Glu Ala Arg Lys Gln Leu Met Ile Tyr Arg 
    530                 535                 540                 


Leu Pro Gln Val Leu Arg Leu His Leu Lys Arg Phe Arg Trp Ser Gly 
545                 550                 555                 560 


Arg Asn His Arg Glu Lys Ile Gly Val His Val Val Phe Asp Gln Val 
                565                 570                 575     


Leu Thr Met Glu Pro Tyr Cys Cys Arg Asp Met Leu Ser Ser Leu Asp 
            580                 585                 590         


Lys Glu Thr Phe Ala Tyr Asp Leu Ser Ala Val Val Met His His Gly 
        595                 600                 605             


Lys Gly Phe Gly Ser Gly His Tyr Thr Ala Tyr Cys Tyr Asn Thr Glu 
    610                 615                 620                 


Gly Gly Phe Trp Val His Cys Asn Asp Ser Lys Leu Asn Val Cys Ser 
625                 630                 635                 640 


Val Glu Glu Val Cys Lys Thr Gln Ala Tyr Ile Leu Phe Tyr Thr Gln 
                645                 650                 655     


Arg Thr 
        


<210> 142
<211> 300
<212> PRT
<213> Homo sapiens

<400> 142
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Leu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


Pro Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Cys 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly Tyr Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 143
<211> 311
<212> PRT
<213> Homo sapiens

<400> 143
Thr Gly Tyr Val Gly Leu Lys Asn Gln Gly Ala Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Leu Leu Gln Thr Leu Phe Phe Thr Asn Gln Leu Arg Lys Ala Val 
            20                  25                  30          


Tyr Met Met Pro Thr Glu Gly Asp Asp Ser Ser Lys Ser Val Pro Leu 
        35                  40                  45              


Ala Leu Gln Arg Val Phe Tyr Glu Leu Gln His Ser Asp Lys Pro Val 
    50                  55                  60                  


Gly Thr Lys Lys Leu Thr Lys Ser Phe Gly Trp Glu Thr Leu Asp Ser 
65                  70                  75                  80  


Phe Met Gln His Asp Val Gln Glu Leu Cys Arg Val Leu Leu Asp Asn 
                85                  90                  95      


Val Glu Asn Lys Met Lys Gly Thr Cys Val Glu Gly Thr Ile Pro Lys 
            100                 105                 110         


Leu Phe Arg Gly Lys Met Val Ser Tyr Ile Gln Cys Lys Glu Val Asp 
        115                 120                 125             


Tyr Arg Ser Asp Arg Arg Glu Asp Tyr Tyr Asp Ile Gln Leu Ser Ile 
    130                 135                 140                 


Lys Gly Lys Lys Asn Ile Phe Glu Ser Phe Val Asp Tyr Val Ala Val 
145                 150                 155                 160 


Glu Gln Leu Asp Gly Asp Asn Lys Tyr Asp Ala Gly Glu His Gly Leu 
                165                 170                 175     


Gln Glu Ala Glu Lys Gly Val Lys Phe Leu Thr Leu Pro Pro Val Leu 
            180                 185                 190         


His Leu Gln Leu Met Arg Phe Met Tyr Asp Pro Gln Thr Asp Gln Asn 
        195                 200                 205             


Ile Lys Ile Asn Asp Arg Phe Glu Phe Pro Glu Gln Leu Pro Leu Asp 
    210                 215                 220                 


Glu Phe Leu Gln Lys Thr Asp Pro Lys Asp Pro Ala Asn Tyr Ile Leu 
225                 230                 235                 240 


His Ala Val Leu Val His Ser Gly Asp Asn His Gly Gly His Tyr Val 
                245                 250                 255     


Val Tyr Leu Asn Pro Lys Gly Asp Gly Lys Trp Cys Lys Phe Asp Asp 
            260                 265                 270         


Asp Val Val Ser Arg Cys Thr Lys Glu Glu Ala Ile Glu His Asn Tyr 
        275                 280                 285             


Gly Gly His Asp Asp Asp Leu Ser Val Arg His Cys Thr Asn Ala Tyr 
    290                 295                 300                 


Met Leu Val Tyr Ile Arg Glu 
305                 310     


<210> 144
<211> 338
<212> PRT
<213> Homo sapiens

<400> 144
Ala Gln Gly Leu Ala Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Ile Leu Gln Cys Leu Ser Asn Thr Arg Glu Leu Arg Asp Tyr 
            20                  25                  30          


Cys Leu Gln Arg Leu Tyr Met Arg Asp Leu His His Gly Ser Asn Ala 
        35                  40                  45              


His Thr Ala Leu Val Glu Glu Phe Ala Lys Leu Ile Gln Thr Ile Trp 
    50                  55                  60                  


Thr Ser Ser Pro Asn Asp Val Val Ser Pro Ser Glu Phe Lys Thr Gln 
65                  70                  75                  80  


Ile Gln Arg Tyr Ala Pro Arg Phe Val Gly Tyr Asn Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Arg Phe Leu Leu Asp Gly Leu His Asn Glu Val Asn 
            100                 105                 110         


Arg Val Thr Leu Arg Pro Lys Ser Asn Pro Glu Asn Leu Asp His Leu 
        115                 120                 125             


Pro Asp Asp Glu Lys Gly Arg Gln Met Trp Arg Lys Tyr Leu Glu Arg 
    130                 135                 140                 


Glu Asp Ser Arg Ile Gly Asp Leu Phe Val Gly Gln Leu Lys Ser Ser 
145                 150                 155                 160 


Leu Thr Cys Thr Asp Cys Gly Tyr Cys Ser Thr Val Phe Asp Pro Phe 
                165                 170                 175     


Trp Asp Leu Ser Leu Pro Ile Ala Lys Arg Gly Tyr Pro Glu Val Thr 
            180                 185                 190         


Leu Met Asp Cys Met Arg Leu Phe Thr Lys Glu Asp Val Leu Asp Gly 
        195                 200                 205             


Asp Glu Lys Pro Thr Cys Cys Arg Cys Arg Gly Arg Lys Arg Cys Ile 
    210                 215                 220                 


Lys Lys Phe Ser Ile Gln Arg Phe Pro Lys Ile Leu Val Leu His Leu 
225                 230                 235                 240 


Lys Arg Phe Ser Glu Ser Arg Ile Arg Thr Ser Lys Leu Thr Thr Phe 
                245                 250                 255     


Val Asn Phe Pro Leu Arg Asp Leu Asp Leu Arg Glu Phe Ala Ser Glu 
            260                 265                 270         


Asn Thr Asn His Ala Val Tyr Asn Leu Tyr Ala Val Ser Asn His Ser 
        275                 280                 285             


Gly Thr Thr Met Gly Gly His Tyr Thr Ala Tyr Cys Arg Ser Pro Gly 
    290                 295                 300                 


Thr Gly Glu Trp His Thr Phe Asn Asp Ser Ser Val Thr Pro Met Ser 
305                 310                 315                 320 


Ser Ser Gln Val Arg Thr Ser Asp Ala Tyr Leu Leu Phe Tyr Glu Leu 
                325                 330                 335     


Ala Ser 
        


<210> 145
<211> 363
<212> PRT
<213> Homo sapiens

<400> 145
Met Ile Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Asp Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser Ser Val Leu Asp 
            20                  25                  30          


Thr Val Leu Leu Arg Pro Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser 
        35                  40                  45              


Glu Thr Gln Glu Leu Leu Arg Thr Glu Ile Val Asn Pro Leu Arg Ile 
    50                  55                  60                  


Tyr Gly Tyr Val Cys Ala Thr Lys Ile Met Lys Leu Arg Lys Ile Leu 
65                  70                  75                  80  


Glu Lys Val Glu Ala Ala Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro 
                85                  90                  95      


Glu Glu Phe Leu Asn Ile Leu Phe His His Ile Leu Arg Val Glu Pro 
            100                 105                 110         


Leu Leu Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe 
        115                 120                 125             


Tyr Gln Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Thr Ile 
    130                 135                 140                 


Gln Gln Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala 
145                 150                 155                 160 


Glu Ala Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys Asp 
                165                 170                 175     


Phe Lys Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr 
            180                 185                 190         


Asp Leu Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu 
        195                 200                 205             


Ala Met Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala 
    210                 215                 220                 


Gly Lys Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr Gln Val His Leu 
225                 230                 235                 240 


His Pro Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser Leu Pro Lys 
                245                 250                 255     


Asp Leu Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln Asn 
            260                 265                 270         


Met Glu Leu Phe Ala Val Leu Cys Ile Glu Thr Ser His Tyr Val Ala 
        275                 280                 285             


Phe Val Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser 
    290                 295                 300                 


Met Ala Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln Val 
305                 310                 315                 320 


Thr Pro Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp 
                325                 330                 335     


Leu His Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu 
            340                 345                 350         


Leu Cys Asp Ala Tyr Met Cys Met Tyr Gln Ser 
        355                 360             


<210> 146
<211> 300
<212> PRT
<213> Homo sapiens

<400> 146
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 147
<211> 341
<212> PRT
<213> Homo sapiens

<400> 147
Leu Gly Asn Thr Cys Phe Met Asn Cys Ile Val Gln Ala Leu Thr His 
1               5                   10                  15      


Thr Pro Leu Leu Arg Asp Phe Phe Leu Ser Asp Arg His Arg Cys Glu 
            20                  25                  30          


Met Gln Ser Pro Ser Ser Cys Leu Val Cys Glu Met Ser Ser Leu Phe 
        35                  40                  45              


Gln Glu Phe Tyr Ser Gly His Arg Ser Pro His Ile Pro Tyr Lys Leu 
    50                  55                  60                  


Leu His Leu Val Trp Thr His Ala Arg His Leu Ala Gly Tyr Glu Gln 
65                  70                  75                  80  


Gln Asp Ala His Glu Phe Leu Ile Ala Ala Leu Asp Val Leu His Arg 
                85                  90                  95      


His Cys Lys Gly Asp Asp Asn Gly Lys Lys Ala Asn Asn Pro Asn His 
            100                 105                 110         


Cys Asn Cys Ile Ile Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp 
        115                 120                 125             


Val Thr Cys Gln Val Cys His Gly Val Ser Thr Thr Ile Asp Pro Phe 
    130                 135                 140                 


Trp Asp Ile Ser Leu Asp Leu Pro Gly Ser Ser Thr Pro Phe Trp Pro 
145                 150                 155                 160 


Leu Ser Pro Gly Ser Glu Gly Asn Val Val Asn Gly Glu Ser His Val 
                165                 170                 175     


Ser Gly Thr Thr Thr Leu Thr Asp Cys Leu Arg Arg Phe Thr Arg Pro 
            180                 185                 190         


Glu His Leu Gly Ser Ser Ala Lys Ile Lys Cys Ser Gly Cys His Ser 
        195                 200                 205             


Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met Lys Lys Leu Pro Ile Val 
    210                 215                 220                 


Ala Cys Phe His Leu Lys Arg Phe Glu His Ser Ala Lys Leu Arg Arg 
225                 230                 235                 240 


Lys Ile Thr Thr Tyr Val Ser Phe Pro Leu Glu Leu Asp Met Thr Pro 
                245                 250                 255     


Phe Met Ala Ser Ser Lys Glu Ser Arg Met Asn Gly Gln Tyr Gln Gln 
            260                 265                 270         


Pro Thr Asp Ser Leu Asn Asn Asp Asn Lys Tyr Ser Leu Phe Ala Val 
        275                 280                 285             


Val Asn His Gln Gly Thr Leu Glu Ser Gly His Tyr Thr Ser Phe Ile 
    290                 295                 300                 


Arg Gln His Lys Asp Gln Trp Phe Lys Cys Asp Asp Ala Ile Ile Thr 
305                 310                 315                 320 


Lys Ala Ser Ile Lys Asp Val Leu Asp Ser Glu Gly Tyr Leu Leu Phe 
                325                 330                 335     


Tyr His Lys Gln Phe 
            340     


<210> 148
<211> 440
<212> PRT
<213> Homo sapiens

<400> 148
Lys Gly Leu Val Pro Gly Leu Val Asn Leu Gly Asn Thr Cys Phe Met 
1               5                   10                  15      


Asn Ser Leu Leu Gln Gly Leu Ser Ala Cys Pro Ala Phe Ile Arg Trp 
            20                  25                  30          


Leu Glu Glu Phe Thr Ser Gln Tyr Ser Arg Asp Gln Lys Glu Pro Pro 
        35                  40                  45              


Ser His Gln Tyr Leu Ser Leu Thr Leu Leu His Leu Leu Lys Ala Leu 
    50                  55                  60                  


Ser Cys Gln Glu Val Thr Asp Asp Glu Val Leu Asp Ala Ser Cys Leu 
65                  70                  75                  80  


Leu Asp Val Leu Arg Met Tyr Arg Trp Gln Ile Ser Ser Phe Glu Glu 
                85                  90                  95      


Gln Asp Ala His Glu Leu Phe His Val Ile Thr Ser Ser Leu Glu Asp 
            100                 105                 110         


Glu Arg Asp Arg Gln Pro Arg Val Thr His Leu Phe Asp Val His Ser 
        115                 120                 125             


Leu Glu Gln Gln Ser Glu Ile Thr Pro Lys Gln Ile Thr Cys Arg Thr 
    130                 135                 140                 


Arg Gly Ser Pro His Pro Thr Ser Asn His Trp Lys Ser Gln His Pro 
145                 150                 155                 160 


Phe His Gly Arg Leu Thr Ser Asn Met Val Cys Lys His Cys Glu His 
                165                 170                 175     


Gln Ser Pro Val Arg Phe Asp Thr Phe Asp Ser Leu Ser Leu Ser Ile 
            180                 185                 190         


Pro Ala Ala Thr Trp Gly His Pro Leu Thr Leu Asp His Cys Leu His 
        195                 200                 205             


His Phe Ile Ser Ser Glu Ser Val Arg Asp Val Val Cys Asp Asn Cys 
    210                 215                 220                 


Thr Lys Ile Glu Ala Lys Gly Thr Leu Asn Gly Glu Lys Val Glu His 
225                 230                 235                 240 


Gln Arg Thr Thr Phe Val Lys Gln Leu Lys Leu Gly Lys Leu Pro Gln 
                245                 250                 255     


Cys Leu Cys Ile His Leu Gln Arg Leu Ser Trp Ser Ser His Gly Thr 
            260                 265                 270         


Pro Leu Lys Arg His Glu His Val Gln Phe Asn Glu Phe Leu Met Met 
        275                 280                 285             


Asp Ile Tyr Lys Tyr His Leu Leu Gly His Lys Pro Ser Gln His Asn 
    290                 295                 300                 


Pro Lys Leu Asn Lys Asn Pro Gly Pro Thr Leu Glu Leu Gln Asp Gly 
305                 310                 315                 320 


Pro Gly Ala Pro Thr Pro Val Leu Asn Gln Pro Gly Ala Pro Lys Thr 
                325                 330                 335     


Gln Ile Phe Met Asn Gly Ala Cys Ser Pro Ser Leu Leu Pro Thr Leu 
            340                 345                 350         


Ser Ala Pro Met Pro Phe Pro Leu Pro Val Val Pro Asp Tyr Ser Ser 
        355                 360                 365             


Ser Thr Tyr Leu Phe Arg Leu Met Ala Val Val Val His His Gly Asp 
    370                 375                 380                 


Met His Ser Gly His Phe Val Thr Tyr Arg Arg Ser Pro Pro Ser Ala 
385                 390                 395                 400 


Arg Asn Pro Leu Ser Thr Ser Asn Gln Trp Leu Trp Val Ser Asp Asp 
                405                 410                 415     


Thr Val Arg Lys Ala Ser Leu Gln Glu Val Leu Ser Ser Ser Ala Tyr 
            420                 425                 430         


Leu Leu Phe Tyr Glu Arg Val Leu 
        435                 440 


<210> 149
<211> 496
<212> PRT
<213> Homo sapiens

<400> 149
Gly Trp Pro Val Gly Leu Lys Asn Val Gly Asn Thr Cys Trp Phe Ser 
1               5                   10                  15      


Ala Val Ile Gln Ser Leu Phe Gln Leu Pro Glu Phe Arg Arg Leu Val 
            20                  25                  30          


Leu Ser Tyr Ser Leu Pro Gln Asn Val Leu Glu Asn Cys Arg Ser His 
        35                  40                  45              


Thr Glu Lys Arg Asn Ile Met Phe Met Gln Glu Leu Gln Tyr Leu Phe 
    50                  55                  60                  


Ala Leu Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala 
65                  70                  75                  80  


Leu Asp Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Gln 
                85                  90                  95      


Asp Val Ser Glu Phe Thr His Lys Leu Leu Asp Trp Leu Glu Asp Ala 
            100                 105                 110         


Phe Gln Leu Ala Val Asn Val Asn Ser Pro Arg Asn Lys Ser Glu Asn 
        115                 120                 125             


Pro Met Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg 
    130                 135                 140                 


Glu Gly Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu 
145                 150                 155                 160 


Gln Val Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met 
                165                 170                 175     


Val Glu Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr 
            180                 185                 190         


Gly Gln Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu 
        195                 200                 205             


Leu Ser Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile 
    210                 215                 220                 


His Asn Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met 
225                 230                 235                 240 


Tyr Arg Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys 
                245                 250                 255     


Leu Lys Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val 
            260                 265                 270         


Lys Tyr Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys 
        275                 280                 285             


Tyr Val Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro 
    290                 295                 300                 


Pro Glu Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys 
305                 310                 315                 320 


Ser Val Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser 
                325                 330                 335     


Ser Gln Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro 
            340                 345                 350         


Lys Ser Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser 
        355                 360                 365             


Gln Pro Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys 
    370                 375                 380                 


Thr Cys Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp 
385                 390                 395                 400 


Leu Lys Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr 
                405                 410                 415     


Cys Asp Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu 
            420                 425                 430         


Val His Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr 
        435                 440                 445             


Asn Gln Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr 
    450                 455                 460                 


Glu Ser Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg 
465                 470                 475                 480 


Asn Val Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr 
                485                 490                 495     


<210> 150
<211> 300
<212> PRT
<213> Homo sapiens

<400> 150
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Lys Val Thr Ala Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 151
<211> 644
<212> PRT
<213> Homo sapiens

<400> 151
Pro Val Pro Gly Val Ala Gly Leu Arg Asn His Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ala Thr Leu Gln Cys Leu Ser Asn Thr Glu Leu Phe Ala Glu 
            20                  25                  30          


Tyr Leu Ala Leu Gly Gln Tyr Arg Ala Gly Arg Pro Glu Pro Ser Pro 
        35                  40                  45              


Asp Pro Glu Gln Pro Ala Gly Arg Gly Ala Gln Gly Gln Gly Glu Val 
    50                  55                  60                  


Thr Glu Gln Leu Ala His Leu Val Arg Ala Leu Trp Thr Leu Glu Tyr 
65                  70                  75                  80  


Thr Pro Gln His Ser Arg Asp Phe Lys Thr Ile Val Ser Lys Asn Ala 
                85                  90                  95      


Leu Gln Tyr Arg Gly Asn Ser Gln His Asp Ala Gln Glu Phe Leu Leu 
            100                 105                 110         


Trp Leu Leu Asp Arg Val His Glu Asp Leu Asn His Ser Val Lys Gln 
        115                 120                 125             


Ser Gly Gln Pro Pro Leu Lys Pro Pro Ser Glu Thr Asp Met Met Pro 
    130                 135                 140                 


Glu Gly Pro Ser Phe Pro Val Cys Ser Thr Phe Val Gln Glu Leu Phe 
145                 150                 155                 160 


Gln Ala Gln Tyr Arg Ser Ser Leu Thr Cys Pro His Cys Gln Lys Gln 
                165                 170                 175     


Ser Asn Thr Phe Asp Pro Phe Leu Cys Ile Ser Leu Pro Ile Pro Leu 
            180                 185                 190         


Pro His Thr Arg Pro Leu Tyr Val Thr Val Val Tyr Gln Gly Lys Cys 
        195                 200                 205             


Ser His Cys Met Arg Ile Gly Val Ala Val Pro Leu Ser Gly Thr Val 
    210                 215                 220                 


Ala Arg Leu Arg Glu Ala Val Ser Met Glu Thr Lys Ile Pro Thr Asp 
225                 230                 235                 240 


Gln Ile Val Leu Thr Glu Met Tyr Tyr Asp Gly Phe His Arg Ser Phe 
                245                 250                 255     


Cys Asp Thr Asp Asp Leu Glu Thr Val His Glu Ser Asp Cys Ile Phe 
            260                 265                 270         


Ala Phe Glu Thr Pro Glu Ile Phe Arg Pro Glu Gly Ile Leu Ser Gln 
        275                 280                 285             


Arg Gly Ile His Leu Asn Asn Asn Leu Asn His Leu Lys Phe Gly Leu 
    290                 295                 300                 


Asp Tyr His Arg Leu Ser Ser Pro Thr Gln Thr Ala Ala Lys Gln Gly 
305                 310                 315                 320 


Lys Met Asp Ser Pro Thr Ser Arg Ala Gly Ser Asp Lys Ile Val Leu 
                325                 330                 335     


Leu Val Cys Asn Arg Ala Cys Thr Gly Gln Gln Gly Lys Arg Phe Gly 
            340                 345                 350         


Leu Pro Phe Val Leu His Leu Glu Lys Thr Ile Ala Trp Asp Leu Leu 
        355                 360                 365             


Gln Lys Glu Ile Leu Glu Lys Met Lys Tyr Phe Leu Arg Pro Thr Val 
    370                 375                 380                 


Cys Ile Gln Val Cys Pro Phe Ser Leu Arg Val Val Ser Val Val Gly 
385                 390                 395                 400 


Ile Thr Tyr Leu Leu Pro Gln Glu Glu Gln Pro Leu Cys His Pro Ile 
                405                 410                 415     


Val Glu Arg Ala Leu Lys Ser Cys Gly Pro Gly Gly Thr Ala His Val 
            420                 425                 430         


Lys Leu Val Val Glu Trp Asp Lys Glu Thr Arg Asp Phe Leu Phe Val 
        435                 440                 445             


Asn Thr Glu Asp Glu Tyr Ile Pro Asp Ala Glu Ser Val Arg Leu Gln 
    450                 455                 460                 


Arg Glu Arg His His Gln Pro Gln Thr Cys Thr Leu Ser Gln Cys Phe 
465                 470                 475                 480 


Gln Leu Tyr Thr Lys Glu Glu Arg Leu Ala Pro Asp Asp Ala Trp Arg 
                485                 490                 495     


Cys Pro His Cys Lys Gln Leu Gln Gln Gly Ser Ile Thr Leu Ser Leu 
            500                 505                 510         


Trp Thr Leu Pro Asp Val Leu Ile Ile His Leu Lys Arg Phe Arg Gln 
        515                 520                 525             


Glu Gly Asp Arg Arg Met Lys Leu Gln Asn Met Val Lys Phe Pro Leu 
    530                 535                 540                 


Thr Gly Leu Asp Met Thr Pro His Val Val Lys Arg Ser Gln Ser Ser 
545                 550                 555                 560 


Trp Ser Leu Pro Ser His Trp Ser Pro Trp Arg Arg Pro Tyr Gly Leu 
                565                 570                 575     


Gly Arg Asp Pro Glu Asp Tyr Ile Tyr Asp Leu Tyr Ala Val Cys Asn 
            580                 585                 590         


His His Gly Thr Met Gln Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn 
        595                 600                 605             


Ser Val Asp Gly Leu Trp Tyr Cys Phe Asp Asp Ser Asp Val Gln Gln 
    610                 615                 620                 


Leu Ser Glu Asp Glu Val Cys Thr Gln Thr Ala Tyr Ile Leu Phe Tyr 
625                 630                 635                 640 


Gln Arg Arg Thr 
                


<210> 152
<211> 344
<212> PRT
<213> Homo sapiens

<400> 152
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Thr Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Glu Trp Glu Arg 
    290                 295                 300                 


His Ser Glu Ser Val Ser Arg Gly Arg Glu Pro Arg Ala Leu Gly Ala 
305                 310                 315                 320 


Glu Asp Thr Asp Arg Arg Ala Thr Gln Gly Glu Leu Lys Arg Asp His 
                325                 330                 335     


Pro Cys Leu Gln Ala Pro Glu Leu 
            340                 


<210> 153
<211> 300
<212> PRT
<213> Homo sapiens

<400> 153
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Asp Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Lys Leu Tyr Met Ser Gln Thr Asn Ser Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 154
<211> 382
<212> PRT
<213> Homo sapiens

<400> 154
Glu Thr Gly Tyr Val Gly Leu Val Asn Gln Ala Met Thr Cys Tyr Leu 
1               5                   10                  15      


Asn Ser Leu Leu Gln Thr Leu Phe Met Thr Pro Glu Phe Arg Asn Ala 
            20                  25                  30          


Leu Tyr Lys Trp Glu Phe Glu Glu Ser Glu Glu Asp Pro Val Thr Ser 
        35                  40                  45              


Ile Pro Tyr Gln Leu Gln Arg Leu Phe Val Leu Leu Gln Thr Ser Lys 
    50                  55                  60                  


Lys Arg Ala Ile Glu Thr Thr Asp Val Thr Arg Ser Phe Gly Trp Asp 
65                  70                  75                  80  


Ser Ser Glu Ala Trp Gln Gln His Asp Val Gln Glu Leu Cys Arg Val 
                85                  90                  95      


Met Phe Asp Ala Leu Glu Gln Lys Trp Lys Gln Thr Glu Gln Ala Asp 
            100                 105                 110         


Leu Ile Asn Glu Leu Tyr Gln Gly Lys Leu Lys Asp Tyr Val Arg Cys 
        115                 120                 125             


Leu Glu Cys Gly Tyr Glu Gly Trp Arg Ile Asp Thr Tyr Leu Asp Ile 
    130                 135                 140                 


Pro Leu Val Ile Arg Pro Tyr Gly Ser Ser Gln Ala Phe Ala Ser Val 
145                 150                 155                 160 


Glu Glu Ala Leu His Ala Phe Ile Gln Pro Glu Ile Leu Asp Gly Pro 
                165                 170                 175     


Asn Gln Tyr Phe Cys Glu Arg Cys Lys Lys Lys Cys Asp Ala Arg Lys 
            180                 185                 190         


Gly Leu Arg Phe Leu His Phe Pro Tyr Leu Leu Thr Leu Gln Leu Lys 
        195                 200                 205             


Arg Phe Asp Phe Asp Tyr Thr Thr Met His Arg Ile Lys Leu Asn Asp 
    210                 215                 220                 


Arg Met Thr Phe Pro Glu Glu Leu Asp Met Ser Thr Phe Ile Asp Val 
225                 230                 235                 240 


Glu Asp Glu Lys Ser Pro Gln Thr Glu Ser Cys Thr Asp Ser Gly Ala 
                245                 250                 255     


Glu Asn Glu Gly Ser Cys His Ser Asp Gln Met Ser Asn Asp Phe Ser 
            260                 265                 270         


Asn Asp Asp Gly Val Asp Glu Gly Ile Cys Leu Glu Thr Asn Ser Gly 
        275                 280                 285             


Thr Glu Lys Ile Ser Lys Ser Gly Leu Glu Lys Asn Ser Leu Ile Tyr 
    290                 295                 300                 


Glu Leu Phe Ser Val Met Val His Ser Gly Ser Ala Ala Gly Gly His 
305                 310                 315                 320 


Tyr Tyr Ala Cys Ile Lys Ser Phe Ser Asp Glu Gln Trp Tyr Ser Phe 
                325                 330                 335     


Asn Asp Gln His Val Ser Arg Ile Thr Gln Glu Asp Ile Lys Lys Thr 
            340                 345                 350         


His Gly Gly Ser Ser Gly Ser Arg Gly Tyr Tyr Ser Ser Ala Phe Ala 
        355                 360                 365             


Ser Ser Thr Asn Ala Tyr Met Leu Ile Tyr Arg Leu Lys Asp 
    370                 375                 380         


<210> 155
<211> 350
<212> PRT
<213> Homo sapiens

<400> 155
Tyr Thr Val Gly Leu Arg Gly Leu Ile Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Cys Ile Val Gln Ala Leu Thr His Ile Pro Leu Leu Lys Asp 
            20                  25                  30          


Phe Phe Leu Ser Asp Lys His Lys Cys Ile Met Thr Ser Pro Ser Leu 
        35                  40                  45              


Cys Leu Val Cys Glu Met Ser Ser Leu Phe His Ala Met Tyr Ser Gly 
    50                  55                  60                  


Ser Arg Thr Pro His Ile Pro Tyr Lys Leu Leu His Leu Ile Trp Ile 
65                  70                  75                  80  


His Ala Glu His Leu Ala Gly Tyr Arg Gln Gln Asp Ala His Glu Phe 
                85                  90                  95      


Leu Ile Ala Ile Leu Asp Val Leu His Arg His Ser Lys Asp Asp Ser 
            100                 105                 110         


Gly Gly Gln Glu Ala Asn Asn Pro Asn Cys Cys Asn Cys Ile Ile Asp 
        115                 120                 125             


Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val Thr Cys Gln Ala Cys 
    130                 135                 140                 


His Ser Val Ser Thr Thr Ile Asp Pro Cys Trp Asp Ile Ser Leu Asp 
145                 150                 155                 160 


Leu Pro Gly Ser Cys Ala Thr Phe Asp Ser Gln Asn Pro Glu Arg Ala 
                165                 170                 175     


Asp Ser Thr Val Ser Arg Asp Asp His Ile Pro Gly Ile Pro Ser Leu 
            180                 185                 190         


Thr Asp Cys Leu Gln Trp Phe Thr Arg Pro Glu His Leu Gly Ser Ser 
        195                 200                 205             


Ala Lys Ile Lys Cys Asn Ser Cys Gln Ser Tyr Gln Glu Ser Thr Lys 
    210                 215                 220                 


Gln Leu Thr Met Lys Lys Leu Pro Ile Val Ala Cys Phe His Leu Lys 
225                 230                 235                 240 


Arg Phe Glu His Val Gly Lys Gln Arg Arg Lys Ile Asn Thr Phe Ile 
                245                 250                 255     


Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe Leu Ala Ser Thr Lys 
            260                 265                 270         


Glu Ser Arg Met Lys Glu Gly Gln Pro Pro Thr Asp Cys Val Pro Asn 
        275                 280                 285             


Glu Asn Lys Tyr Ser Leu Phe Ala Val Ile Asn His His Gly Thr Leu 
    290                 295                 300                 


Glu Ser Gly His Tyr Thr Ser Phe Ile Arg Gln Gln Lys Asp Gln Trp 
305                 310                 315                 320 


Phe Ser Cys Asp Asp Ala Ile Ile Thr Lys Ala Thr Ile Glu Asp Leu 
                325                 330                 335     


Leu Tyr Ser Glu Gly Tyr Leu Leu Phe Tyr His Lys Gln Gly 
            340                 345                 350 


<210> 156
<211> 306
<212> PRT
<213> Homo sapiens

<400> 156
Arg Val Gly Ala Gly Leu His Asn Leu Gly Asn Thr Cys Phe Leu Asn 
1               5                   10                  15      


Ala Thr Ile Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Leu 
            20                  25                  30          


Leu Ser Lys Glu His Ala Arg Ser Cys His Gln Gly Ser Phe Cys Met 
        35                  40                  45              


Leu Cys Val Met Gln Asn His Ile Val Gln Ala Phe Ala Asn Ser Gly 
    50                  55                  60                  


Asn Ala Ile Lys Pro Val Ser Phe Ile Arg Asp Leu Lys Lys Ile Ala 
65                  70                  75                  80  


Arg His Phe Arg Phe Gly Asn Gln Glu Asp Ala His Glu Phe Leu Arg 
                85                  90                  95      


Tyr Thr Ile Asp Ala Met Gln Lys Ala Cys Leu Asn Gly Cys Ala Lys 
            100                 105                 110         


Leu Asp Arg Gln Thr Gln Ala Thr Thr Leu Val His Gln Ile Phe Gly 
        115                 120                 125             


Gly Tyr Leu Arg Ser Arg Val Lys Cys Ser Val Cys Lys Ser Val Ser 
    130                 135                 140                 


Asp Thr Tyr Asp Pro Tyr Leu Asp Val Ala Leu Glu Ile Arg Gln Ala 
145                 150                 155                 160 


Ala Asn Ile Val Arg Ala Leu Glu Leu Phe Val Lys Ala Asp Val Leu 
                165                 170                 175     


Ser Gly Glu Asn Ala Tyr Met Cys Ala Lys Cys Lys Lys Lys Val Pro 
            180                 185                 190         


Ala Ser Lys Arg Phe Thr Ile His Arg Thr Ser Asn Val Leu Thr Leu 
        195                 200                 205             


Ser Leu Lys Arg Phe Ala Asn Phe Ser Gly Gly Lys Ile Thr Lys Asp 
    210                 215                 220                 


Val Gly Tyr Pro Glu Phe Leu Asn Ile Arg Pro Tyr Met Ser Gln Asn 
225                 230                 235                 240 


Asn Gly Asp Pro Val Met Tyr Gly Leu Tyr Ala Val Leu Val His Ser 
                245                 250                 255     


Gly Tyr Ser Cys His Ala Gly His Tyr Tyr Cys Tyr Val Lys Ala Ser 
            260                 265                 270         


Asn Gly Gln Trp Tyr Gln Met Asn Asp Ser Leu Val His Ser Ser Asn 
        275                 280                 285             


Val Lys Val Val Leu Asn Gln Gln Ala Tyr Val Leu Phe Tyr Leu Arg 
    290                 295                 300                 


Ile Pro 
305     


<210> 157
<211> 411
<212> PRT
<213> Homo sapiens

<400> 157
Thr Pro Gly Val Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met 
1               5                   10                  15      


Asn Ser Val Leu Gln Val Leu Ser His Leu Leu Ile Phe Arg Gln Cys 
            20                  25                  30          


Phe Leu Lys Leu Asp Leu Asn Gln Trp Leu Ala Met Thr Ala Ser Glu 
        35                  40                  45              


Lys Thr Arg Ser Cys Lys His Pro Pro Val Thr Asp Thr Val Val Tyr 
    50                  55                  60                  


Gln Met Asn Glu Cys Gln Glu Lys Asp Thr Gly Phe Val Cys Ser Arg 
65                  70                  75                  80  


Gln Ser Ser Leu Ser Ser Gly Leu Ser Gly Gly Ala Ser Lys Gly Arg 
                85                  90                  95      


Lys Met Glu Leu Ile Gln Pro Lys Glu Pro Thr Ser Gln Tyr Ile Ser 
            100                 105                 110         


Leu Cys His Glu Leu His Thr Leu Phe Gln Val Met Trp Ser Gly Lys 
        115                 120                 125             


Trp Ala Leu Val Ser Pro Phe Ala Met Leu His Ser Val Trp Arg Leu 
    130                 135                 140                 


Ile Pro Ala Phe Arg Gly Tyr Ala Gln Gln Asp Ala Gln Glu Phe Leu 
145                 150                 155                 160 


Cys Glu Leu Leu Asp Lys Ile Gln Arg Glu Leu Glu Thr Thr Gly Thr 
                165                 170                 175     


Ser Leu Pro Ala Leu Ile Pro Thr Ser Gln Arg Lys Leu Ile Lys Gln 
            180                 185                 190         


Val Leu Asn Val Val Asn Asn Ile Phe His Gly Gln Leu Leu Ser Gln 
        195                 200                 205             


Val Thr Cys Leu Ala Cys Asp Asn Lys Ser Asn Thr Ile Glu Pro Phe 
    210                 215                 220                 


Trp Asp Leu Ser Leu Glu Phe Pro Glu Arg Tyr Gln Cys Ser Gly Lys 
225                 230                 235                 240 


Asp Ile Ala Ser Gln Pro Cys Leu Val Thr Glu Met Leu Ala Lys Phe 
                245                 250                 255     


Thr Glu Thr Glu Ala Leu Glu Gly Lys Ile Tyr Val Cys Asp Gln Cys 
            260                 265                 270         


Asn Ser Lys Arg Arg Arg Phe Ser Ser Lys Pro Val Val Leu Thr Glu 
        275                 280                 285             


Ala Gln Lys Gln Leu Met Ile Cys His Leu Pro Gln Val Leu Arg Leu 
    290                 295                 300                 


His Leu Lys Arg Phe Arg Trp Ser Gly Arg Asn Asn Arg Glu Lys Ile 
305                 310                 315                 320 


Gly Val His Val Gly Phe Glu Glu Ile Leu Asn Met Glu Pro Tyr Cys 
                325                 330                 335     


Cys Arg Glu Thr Leu Lys Ser Leu Arg Pro Glu Cys Phe Ile Tyr Asp 
            340                 345                 350         


Leu Ser Ala Val Val Met His His Gly Lys Gly Phe Gly Ser Gly His 
        355                 360                 365             


Tyr Thr Ala Tyr Cys Tyr Asn Ser Glu Gly Gly Phe Trp Val His Cys 
    370                 375                 380                 


Asn Asp Ser Lys Leu Ser Met Cys Thr Met Asp Glu Val Cys Lys Ala 
385                 390                 395                 400 


Gln Ala Tyr Ile Leu Phe Tyr Thr Gln Arg Val 
                405                 410     


<210> 158
<211> 337
<212> PRT
<213> Homo sapiens

<400> 158
Pro Ala Leu Thr Gly Leu Arg Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ser Ile Leu Gln Cys Leu Cys Asn Ala Pro His Leu Ala Asp Tyr Phe 
            20                  25                  30          


Asn Arg Asn Cys Tyr Gln Asp Asp Ile Asn Arg Ser Asn Leu Leu Gly 
        35                  40                  45              


His Lys Gly Glu Val Ala Glu Glu Phe Gly Ile Ile Met Lys Ala Leu 
    50                  55                  60                  


Trp Thr Gly Gln Tyr Arg Tyr Ile Ser Pro Lys Asp Phe Lys Ile Thr 
65                  70                  75                  80  


Ile Gly Lys Ile Asn Asp Gln Phe Ala Gly Tyr Ser Gln Gln Asp Ser 
                85                  90                  95      


Gln Glu Leu Leu Leu Phe Leu Met Asp Gly Leu His Glu Asp Leu Asn 
            100                 105                 110         


Lys Ala Asp Asn Arg Lys Arg Tyr Lys Glu Glu Asn Asn Asp His Leu 
        115                 120                 125             


Asp Asp Phe Lys Ala Ala Glu His Ala Trp Gln Lys His Lys Gln Leu 
    130                 135                 140                 


Asn Glu Ser Ile Ile Val Ala Leu Phe Gln Gly Gln Phe Lys Ser Thr 
145                 150                 155                 160 


Val Gln Cys Leu Thr Cys His Lys Lys Ser Arg Thr Phe Glu Ala Phe 
                165                 170                 175     


Met Tyr Leu Ser Leu Pro Leu Ala Ser Thr Ser Lys Cys Thr Leu Gln 
            180                 185                 190         


Asp Cys Leu Arg Leu Phe Ser Lys Glu Glu Lys Leu Thr Asp Asn Asn 
        195                 200                 205             


Arg Phe Tyr Cys Ser His Cys Arg Ala Arg Arg Asp Ser Leu Lys Lys 
    210                 215                 220                 


Ile Glu Ile Trp Lys Leu Pro Pro Val Leu Leu Val His Leu Lys Arg 
225                 230                 235                 240 


Phe Ser Tyr Asp Gly Arg Trp Lys Gln Lys Leu Gln Thr Ser Val Asp 
                245                 250                 255     


Phe Pro Leu Glu Asn Leu Asp Leu Ser Gln Tyr Val Ile Gly Pro Lys 
            260                 265                 270         


Asn Asn Leu Lys Lys Tyr Asn Leu Phe Ser Val Ser Asn His Tyr Gly 
        275                 280                 285             


Gly Leu Asp Gly Gly His Tyr Thr Ala Tyr Cys Lys Asn Ala Ala Arg 
    290                 295                 300                 


Gln Arg Trp Phe Lys Phe Asp Asp His Glu Val Ser Asp Ile Ser Val 
305                 310                 315                 320 


Ser Ser Val Lys Ser Ser Ala Ala Tyr Ile Leu Phe Tyr Thr Ser Leu 
                325                 330                 335     


Gly 
    


<210> 159
<211> 614
<212> PRT
<213> Homo sapiens

<400> 159
Gln Gln Leu Gln Gly Phe Ser Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Ile Leu Gln Ser Leu Phe Ser Leu Gln Ser Phe Ala Asn Asp Leu 
            20                  25                  30          


Leu Lys Gln Gly Ile Pro Trp Lys Lys Ile Pro Leu Asn Ala Leu Ile 
        35                  40                  45              


Arg Arg Phe Ala His Leu Leu Val Lys Lys Asp Ile Cys Asn Ser Glu 
    50                  55                  60                  


Thr Lys Lys Asp Leu Leu Lys Lys Val Lys Asn Ala Ile Ser Ala Thr 
65                  70                  75                  80  


Ala Glu Arg Phe Ser Gly Tyr Met Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Ser Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn Lys 
            100                 105                 110         


Thr Trp Lys Thr Glu Pro Val Ser Gly Glu Glu Asn Ser Pro Asp Ile 
        115                 120                 125             


Ser Ala Thr Arg Ala Tyr Thr Cys Pro Val Ile Thr Asn Leu Glu Phe 
    130                 135                 140                 


Glu Val Gln His Ser Ile Ile Cys Lys Ala Cys Gly Glu Ile Ile Pro 
145                 150                 155                 160 


Lys Arg Glu Gln Phe Asn Asp Leu Ser Ile Asp Leu Pro Arg Arg Lys 
                165                 170                 175     


Lys Pro Leu Pro Pro Arg Ser Ile Gln Asp Ser Leu Asp Leu Phe Phe 
            180                 185                 190         


Arg Ala Glu Glu Leu Glu Tyr Ser Cys Glu Lys Cys Gly Gly Lys Cys 
        195                 200                 205             


Ala Leu Val Arg His Lys Phe Asn Arg Leu Pro Arg Val Leu Ile Leu 
    210                 215                 220                 


His Leu Lys Arg Tyr Ser Phe Asn Val Ala Leu Ser Leu Asn Asn Lys 
225                 230                 235                 240 


Ile Gly Gln Gln Val Ile Ile Pro Arg Tyr Leu Thr Leu Ser Ser His 
                245                 250                 255     


Cys Thr Glu Asn Thr Lys Pro Pro Phe Thr Leu Gly Trp Ser Ala His 
            260                 265                 270         


Met Ala Ile Ser Arg Pro Leu Lys Ala Ser Gln Met Val Asn Ser Cys 
        275                 280                 285             


Ile Thr Ser Pro Ser Thr Pro Ser Lys Lys Phe Thr Phe Lys Ser Lys 
    290                 295                 300                 


Ser Ser Leu Ala Leu Cys Leu Asp Ser Asp Ser Glu Asp Glu Leu Lys 
305                 310                 315                 320 


Arg Ser Val Ala Leu Ser Gln Arg Leu Cys Glu Met Leu Gly Asn Glu 
                325                 330                 335     


Gln Gln Gln Glu Asp Leu Glu Lys Asp Ser Lys Leu Cys Pro Ile Glu 
            340                 345                 350         


Pro Asp Lys Ser Glu Leu Glu Asn Ser Gly Phe Asp Arg Met Ser Glu 
        355                 360                 365             


Glu Glu Leu Leu Ala Ala Val Leu Glu Ile Ser Lys Arg Asp Ala Ser 
    370                 375                 380                 


Pro Ser Leu Ser His Glu Asp Asp Asp Lys Pro Thr Ser Ser Pro Asp 
385                 390                 395                 400 


Thr Gly Phe Ala Glu Asp Asp Ile Gln Glu Met Pro Glu Asn Pro Asp 
                405                 410                 415     


Thr Met Glu Thr Glu Lys Pro Lys Thr Ile Thr Glu Leu Asp Pro Ala 
            420                 425                 430         


Ser Phe Thr Glu Ile Thr Lys Asp Cys Asp Glu Asn Lys Glu Asn Lys 
        435                 440                 445             


Thr Pro Glu Gly Ser Gln Gly Glu Val Asp Trp Leu Gln Gln Tyr Asp 
    450                 455                 460                 


Met Glu Arg Glu Arg Glu Glu Gln Glu Leu Gln Gln Ala Leu Ala Gln 
465                 470                 475                 480 


Ser Leu Gln Glu Gln Glu Ala Trp Glu Gln Lys Glu Asp Asp Asp Leu 
                485                 490                 495     


Lys Arg Ala Thr Glu Leu Ser Leu Gln Glu Phe Asn Asn Ser Phe Val 
            500                 505                 510         


Asp Ala Leu Gly Ser Asp Glu Asp Ser Gly Asn Glu Asp Val Phe Asp 
        515                 520                 525             


Met Glu Tyr Thr Glu Ala Glu Ala Glu Glu Leu Lys Arg Asn Ala Glu 
    530                 535                 540                 


Thr Gly Asn Leu Pro His Ser Tyr Arg Leu Ile Ser Val Val Ser His 
545                 550                 555                 560 


Ile Gly Ser Thr Ser Ser Ser Gly His Tyr Ile Ser Asp Val Tyr Asp 
                565                 570                 575     


Ile Lys Lys Gln Ala Trp Phe Thr Tyr Asn Asp Leu Glu Val Ser Lys 
            580                 585                 590         


Ile Gln Glu Ala Ala Val Gln Ser Asp Arg Asp Arg Ser Gly Tyr Ile 
        595                 600                 605             


Phe Phe Tyr Met His Lys 
    610                 


<210> 160
<211> 300
<212> PRT
<213> Homo sapiens

<400> 160
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His Pro Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ala Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 161
<211> 300
<212> PRT
<213> Homo sapiens

<400> 161
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ser Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 162
<211> 402
<212> PRT
<213> Homo sapiens

<400> 162
Ala Pro Ser Lys Gly Leu Ser Asn Glu Pro Gly Gln Asn Ser Cys Phe 
1               5                   10                  15      


Leu Asn Ser Ala Leu Gln Val Leu Trp His Leu Asp Ile Phe Arg Arg 
            20                  25                  30          


Ser Phe Arg Gln Leu Thr Thr His Lys Cys Met Gly Asp Ser Cys Ile 
        35                  40                  45              


Phe Cys Ala Leu Lys Gly Ile Phe Asn Gln Phe Gln Cys Ser Ser Glu 
    50                  55                  60                  


Lys Val Leu Pro Ser Asp Thr Leu Arg Ser Ala Leu Ala Lys Thr Phe 
65                  70                  75                  80  


Gln Asp Glu Gln Arg Phe Gln Leu Gly Ile Met Asp Asp Ala Ala Glu 
                85                  90                  95      


Cys Phe Glu Asn Leu Leu Met Arg Ile His Phe His Ile Ala Asp Glu 
            100                 105                 110         


Thr Lys Glu Asp Ile Cys Thr Ala Gln His Cys Ile Ser His Gln Lys 
        115                 120                 125             


Phe Ala Met Thr Leu Phe Glu Gln Cys Val Cys Thr Ser Cys Gly Ala 
    130                 135                 140                 


Thr Ser Asp Pro Leu Pro Phe Ile Gln Met Val His Tyr Ile Ser Thr 
145                 150                 155                 160 


Thr Ser Leu Cys Asn Gln Ala Ile Cys Met Leu Glu Arg Arg Glu Lys 
                165                 170                 175     


Pro Ser Pro Ser Met Phe Gly Glu Leu Leu Gln Asn Ala Ser Thr Met 
            180                 185                 190         


Gly Asp Leu Arg Asn Cys Pro Ser Asn Cys Gly Glu Arg Ile Arg Ile 
        195                 200                 205             


Arg Arg Val Leu Met Asn Ala Pro Gln Ile Ile Thr Ile Gly Leu Val 
    210                 215                 220                 


Trp Asp Ser Asp His Ser Asp Leu Ala Glu Asp Val Ile His Ser Leu 
225                 230                 235                 240 


Gly Thr Cys Leu Lys Leu Gly Asp Leu Phe Phe Arg Val Thr Asp Asp 
                245                 250                 255     


Arg Ala Lys Gln Ser Glu Leu Tyr Leu Val Gly Met Ile Cys Tyr Tyr 
            260                 265                 270         


Gly Lys His Tyr Ser Thr Phe Phe Phe Gln Thr Lys Ile Arg Lys Trp 
        275                 280                 285             


Met Tyr Phe Asp Asp Ala His Val Lys Glu Ile Gly Pro Lys Trp Lys 
    290                 295                 300                 


Asp Val Val Thr Lys Cys Ile Lys Gly His Tyr Gln Pro Leu Leu Leu 
305                 310                 315                 320 


Leu Tyr Ala Asp Pro Gln Gly Thr Pro Val Ser Thr Gln Asp Leu Pro 
                325                 330                 335     


Pro Gln Ala Glu Phe Gln Ser Tyr Ser Arg Thr Cys Tyr Asp Ser Glu 
            340                 345                 350         


Asp Ser Gly Arg Glu Pro Ser Ile Ser Ser Asp Thr Arg Thr Asp Ser 
        355                 360                 365             


Ser Thr Glu Ser Tyr Pro Tyr Lys His Ser His His Glu Ser Val Val 
    370                 375                 380                 


Ser His Phe Ser Ser Asp Ser Gln Gly Thr Val Ile Tyr Asn Val Glu 
385                 390                 395                 400 


Asn Asp 
        


<210> 163
<211> 336
<212> PRT
<213> Homo sapiens

<400> 163
Leu Pro Gly Ile Val Gly Leu Asn Asn Ile Lys Ala Asn Asp Tyr Ala 
1               5                   10                  15      


Asn Ala Val Leu Gln Ala Leu Ser Asn Val Pro Pro Leu Arg Asn Tyr 
            20                  25                  30          


Phe Leu Glu Glu Asp Asn Tyr Lys Asn Ile Lys Arg Pro Pro Gly Asp 
        35                  40                  45              


Ile Met Phe Leu Leu Val Gln Arg Phe Gly Glu Leu Met Arg Lys Leu 
    50                  55                  60                  


Trp Asn Pro Arg Asn Phe Lys Ala His Val Ser Pro His Glu Met Leu 
65                  70                  75                  80  


Gln Ala Val Val Leu Cys Ser Lys Lys Thr Phe Gln Ile Thr Lys Gln 
                85                  90                  95      


Gly Asp Gly Val Asp Phe Leu Ser Trp Phe Leu Asn Ala Leu His Ser 
            100                 105                 110         


Ala Leu Gly Gly Thr Lys Lys Lys Lys Lys Thr Ile Val Thr Asp Val 
        115                 120                 125             


Phe Gln Gly Ser Met Arg Ile Phe Thr Lys Lys Leu Pro His Pro Asp 
    130                 135                 140                 


Leu Pro Ala Glu Glu Lys Glu Gln Leu Leu His Asn Asp Glu Tyr Gln 
145                 150                 155                 160 


Glu Thr Met Val Glu Ser Thr Phe Met Tyr Leu Thr Leu Asp Leu Pro 
                165                 170                 175     


Thr Ala Pro Leu Tyr Lys Asp Glu Lys Glu Gln Leu Ile Ile Pro Gln 
            180                 185                 190         


Val Pro Leu Phe Asn Ile Leu Ala Lys Phe Asn Gly Ile Thr Glu Lys 
        195                 200                 205             


Glu Tyr Lys Thr Tyr Lys Glu Asn Phe Leu Lys Arg Phe Gln Leu Thr 
    210                 215                 220                 


Lys Leu Pro Pro Tyr Leu Ile Phe Cys Ile Lys Arg Phe Thr Lys Asn 
225                 230                 235                 240 


Asn Phe Phe Val Glu Lys Asn Pro Thr Ile Val Asn Phe Pro Ile Thr 
                245                 250                 255     


Asn Val Asp Leu Arg Glu Tyr Leu Ser Glu Glu Val Gln Ala Val His 
            260                 265                 270         


Lys Asn Thr Thr Tyr Asp Leu Ile Ala Asn Ile Val His Asp Gly Lys 
        275                 280                 285             


Pro Ser Glu Gly Ser Tyr Arg Ile His Val Leu His His Gly Thr Gly 
    290                 295                 300                 


Lys Trp Tyr Glu Leu Gln Asp Leu Gln Val Thr Asp Ile Leu Pro Gln 
305                 310                 315                 320 


Met Ile Thr Leu Ser Glu Ala Tyr Ile Gln Ile Trp Lys Arg Arg Asp 
                325                 330                 335     


<210> 164
<211> 492
<212> PRT
<213> Homo sapiens

<400> 164
Ser Asp Thr Gly Lys Ile Gly Leu Ile Asn Leu Gly Asn Thr Cys Tyr 
1               5                   10                  15      


Val Asn Ser Ile Leu Gln Ala Leu Phe Met Ala Ser Asp Phe Arg His 
            20                  25                  30          


Cys Val Leu Arg Leu Thr Glu Asn Asn Ser Gln Pro Leu Met Thr Lys 
        35                  40                  45              


Leu Gln Trp Leu Phe Gly Phe Leu Glu His Ser Gln Arg Pro Ala Ile 
    50                  55                  60                  


Ser Pro Glu Asn Phe Leu Ser Ala Ser Trp Thr Pro Trp Phe Ser Pro 
65                  70                  75                  80  


Gly Thr Gln Gln Asp Cys Ser Glu Tyr Leu Lys Tyr Leu Leu Asp Arg 
                85                  90                  95      


Leu His Glu Glu Glu Lys Thr Gly Thr Arg Ile Cys Gln Lys Leu Lys 
            100                 105                 110         


Gln Ser Ser Ser Pro Ser Pro Pro Glu Glu Pro Pro Ala Pro Ser Ser 
        115                 120                 125             


Thr Ser Val Glu Lys Met Phe Gly Gly Lys Ile Val Thr Arg Ile Cys 
    130                 135                 140                 


Cys Leu Cys Cys Leu Asn Val Ser Ser Arg Glu Glu Ala Phe Thr Asp 
145                 150                 155                 160 


Leu Ser Leu Ala Phe Pro Pro Pro Glu Arg Cys Arg Arg Arg Arg Leu 
                165                 170                 175     


Gly Ser Val Met Arg Pro Thr Glu Asp Ile Thr Ala Arg Glu Leu Pro 
            180                 185                 190         


Pro Pro Thr Ser Ala Gln Gly Pro Gly Arg Val Gly Pro Arg Arg Gln 
        195                 200                 205             


Arg Lys His Cys Ile Thr Glu Asp Thr Pro Pro Thr Ser Leu Tyr Ile 
    210                 215                 220                 


Glu Gly Leu Asp Ser Lys Glu Ala Gly Gly Gln Ser Ser Gln Glu Glu 
225                 230                 235                 240 


Arg Ile Glu Arg Glu Glu Glu Gly Lys Glu Glu Arg Thr Glu Lys Glu 
                245                 250                 255     


Glu Val Gly Glu Glu Glu Glu Ser Thr Arg Gly Glu Gly Glu Arg Glu 
            260                 265                 270         


Lys Glu Glu Glu Val Glu Glu Glu Glu Glu Lys Val Glu Lys Glu Thr 
        275                 280                 285             


Glu Lys Glu Ala Glu Gln Glu Lys Glu Glu Asp Ser Leu Gly Ala Gly 
    290                 295                 300                 


Thr His Pro Asp Ala Ala Ile Pro Ser Gly Glu Arg Thr Cys Gly Ser 
305                 310                 315                 320 


Glu Gly Ser Arg Ser Val Leu Asp Leu Val Asn Tyr Phe Leu Ser Pro 
                325                 330                 335     


Glu Lys Leu Thr Ala Glu Asn Arg Tyr Tyr Cys Glu Ser Cys Ala Ser 
            340                 345                 350         


Leu Gln Asp Ala Glu Lys Val Val Glu Leu Ser Gln Gly Pro Cys Tyr 
        355                 360                 365             


Leu Ile Leu Thr Leu Leu Arg Phe Ser Phe Asp Leu Arg Thr Met Arg 
    370                 375                 380                 


Arg Arg Lys Ile Leu Asp Asp Val Ser Ile Pro Leu Leu Leu Arg Leu 
385                 390                 395                 400 


Pro Leu Ala Gly Gly Arg Gly Gln Ala Tyr Asp Leu Cys Ser Val Val 
                405                 410                 415     


Val His Ser Gly Val Ser Ser Glu Ser Gly His Tyr Tyr Cys Tyr Ala 
            420                 425                 430         


Arg Glu Gly Ala Ala Arg Pro Ala Ala Ser Leu Gly Thr Ala Asp Arg 
        435                 440                 445             


Pro Glu Pro Glu Asn Gln Trp Tyr Leu Phe Asn Asp Thr Arg Val Ser 
    450                 455                 460                 


Phe Ser Ser Phe Glu Ser Val Ser Asn Val Thr Ser Phe Phe Pro Lys 
465                 470                 475                 480 


Asp Thr Ala Tyr Val Leu Phe Tyr Arg Gln Arg Pro 
                485                 490         


<210> 165
<211> 651
<212> PRT
<213> Homo sapiens

<400> 165
Glu Gln Pro Gly Leu Cys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Met Asn Ser Ala Ile Gln Cys Leu Ser Asn Thr Pro Pro Leu Thr Glu 
            20                  25                  30          


Tyr Phe Leu Asn Asp Lys Tyr Gln Glu Glu Leu Asn Phe Asp Asn Pro 
        35                  40                  45              


Leu Gly Met Arg Gly Glu Ile Ala Lys Ser Tyr Ala Glu Leu Ile Lys 
    50                  55                  60                  


Gln Met Trp Ser Gly Lys Phe Ser Tyr Val Thr Pro Arg Ala Phe Lys 
65                  70                  75                  80  


Thr Gln Val Gly Arg Phe Ala Pro Gln Phe Ser Gly Tyr Gln Gln Gln 
                85                  90                  95      


Asp Cys Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp 
            100                 105                 110         


Leu Asn Arg Ile Arg Lys Lys Pro Tyr Ile Gln Leu Lys Asp Ala Asp 
        115                 120                 125             


Gly Arg Pro Asp Lys Val Val Ala Glu Glu Ala Trp Glu Asn His Leu 
    130                 135                 140                 


Lys Arg Asn Asp Ser Ile Ile Val Asp Ile Phe His Gly Leu Phe Lys 
145                 150                 155                 160 


Ser Thr Leu Val Cys Pro Glu Cys Ala Lys Ile Ser Val Thr Phe Asp 
                165                 170                 175     


Pro Phe Cys Tyr Leu Thr Leu Pro Leu Pro Met Lys Lys Glu Arg Thr 
            180                 185                 190         


Leu Glu Val Tyr Leu Val Arg Met Asp Pro Leu Thr Lys Pro Met Gln 
        195                 200                 205             


Tyr Lys Val Val Val Pro Lys Ile Gly Asn Ile Leu Asp Leu Cys Thr 
    210                 215                 220                 


Ala Leu Ser Ala Leu Ser Gly Ile Pro Ala Asp Lys Met Ile Val Thr 
225                 230                 235                 240 


Asp Ile Tyr Asn His Arg Phe His Arg Ile Phe Ala Met Asp Glu Asn 
                245                 250                 255     


Leu Ser Ser Ile Met Glu Arg Asp Asp Ile Tyr Val Phe Glu Ile Asn 
            260                 265                 270         


Ile Asn Arg Thr Glu Asp Thr Glu His Val Ile Ile Pro Val Cys Leu 
        275                 280                 285             


Arg Glu Lys Phe Arg His Ser Ser Tyr Thr His His Thr Gly Ser Ser 
    290                 295                 300                 


Leu Phe Gly Gln Pro Phe Leu Met Ala Val Pro Arg Asn Asn Thr Glu 
305                 310                 315                 320 


Asp Lys Leu Tyr Asn Leu Leu Leu Leu Arg Met Cys Arg Tyr Val Lys 
                325                 330                 335     


Ile Ser Thr Glu Thr Glu Glu Thr Glu Gly Ser Leu His Cys Cys Lys 
            340                 345                 350         


Asp Gln Asn Ile Asn Gly Asn Gly Pro Asn Gly Ile His Glu Glu Gly 
        355                 360                 365             


Ser Pro Ser Glu Met Glu Thr Asp Glu Pro Asp Asp Glu Ser Ser Gln 
    370                 375                 380                 


Asp Gln Glu Leu Pro Ser Glu Asn Glu Asn Ser Gln Ser Glu Asp Ser 
385                 390                 395                 400 


Val Gly Gly Asp Asn Asp Ser Glu Asn Gly Leu Cys Thr Glu Asp Thr 
                405                 410                 415     


Cys Lys Gly Gln Leu Thr Gly His Lys Lys Arg Leu Phe Thr Phe Gln 
            420                 425                 430         


Phe Asn Asn Leu Gly Asn Thr Asp Ile Asn Tyr Ile Lys Asp Asp Thr 
        435                 440                 445             


Arg His Ile Arg Phe Asp Asp Arg Gln Leu Arg Leu Asp Glu Arg Ser 
    450                 455                 460                 


Phe Leu Ala Leu Asp Trp Asp Pro Asp Leu Lys Lys Arg Tyr Phe Asp 
465                 470                 475                 480 


Glu Asn Ala Ala Glu Asp Phe Glu Lys His Glu Ser Val Glu Tyr Lys 
                485                 490                 495     


Pro Pro Lys Lys Pro Phe Val Lys Leu Lys Asp Cys Ile Glu Leu Phe 
            500                 505                 510         


Thr Thr Lys Glu Lys Leu Gly Ala Glu Asp Pro Trp Tyr Cys Pro Asn 
        515                 520                 525             


Cys Lys Glu His Gln Gln Ala Thr Lys Lys Leu Asp Leu Trp Ser Leu 
    530                 535                 540                 


Pro Pro Val Leu Val Val His Leu Lys Arg Phe Ser Tyr Ser Arg Tyr 
545                 550                 555                 560 


Met Arg Asp Lys Leu Asp Thr Leu Val Asp Phe Pro Ile Asn Asp Leu 
                565                 570                 575     


Asp Met Ser Glu Phe Leu Ile Asn Pro Asn Ala Gly Pro Cys Arg Tyr 
            580                 585                 590         


Asn Leu Ile Ala Val Ser Asn His Tyr Gly Gly Met Gly Gly Gly His 
        595                 600                 605             


Tyr Thr Ala Phe Ala Lys Asn Lys Asp Asp Gly Lys Trp Tyr Tyr Phe 
    610                 615                 620                 


Asp Asp Ser Ser Val Ser Thr Ala Ser Glu Asp Gln Ile Val Ser Lys 
625                 630                 635                 640 


Ala Ala Tyr Val Leu Phe Tyr Gln Arg Gln Asp 
                645                 650     


<210> 166
<211> 604
<212> PRT
<213> Homo sapiens

<400> 166
Gln Leu Gln Gln Gly Phe Pro Asn Leu Gly Asn Thr Cys Tyr Met Asn 
1               5                   10                  15      


Ala Val Leu Gln Ser Leu Phe Ala Ile Pro Ser Phe Ala Asp Asp Leu 
            20                  25                  30          


Leu Thr Gln Gly Val Pro Trp Glu Tyr Ile Pro Phe Glu Ala Leu Ile 
        35                  40                  45              


Met Thr Leu Thr Gln Leu Leu Ala Leu Lys Asp Phe Cys Ser Thr Lys 
    50                  55                  60                  


Ile Lys Arg Glu Leu Leu Gly Asn Val Lys Lys Val Ile Ser Ala Val 
65                  70                  75                  80  


Ala Glu Ile Phe Ser Gly Asn Met Gln Asn Asp Ala His Glu Phe Leu 
                85                  90                  95      


Gly Gln Cys Leu Asp Gln Leu Lys Glu Asp Met Glu Lys Leu Asn Ala 
            100                 105                 110         


Thr Leu Asn Thr Gly Lys Glu Cys Gly Asp Glu Asn Ser Ser Pro Gln 
        115                 120                 125             


Met His Val Gly Ser Ala Ala Thr Lys Val Phe Val Cys Pro Val Val 
    130                 135                 140                 


Ala Asn Phe Glu Phe Glu Leu Gln Leu Ser Leu Ile Cys Lys Ala Cys 
145                 150                 155                 160 


Gly His Ala Val Leu Lys Val Glu Pro Asn Asn Tyr Leu Ser Ile Asn 
                165                 170                 175     


Leu His Gln Glu Thr Lys Pro Leu Pro Leu Ser Ile Gln Asn Ser Leu 
            180                 185                 190         


Asp Leu Phe Phe Lys Glu Glu Glu Leu Glu Tyr Asn Cys Gln Met Cys 
        195                 200                 205             


Lys Gln Lys Ser Cys Val Ala Arg His Thr Phe Ser Arg Leu Ser Arg 
    210                 215                 220                 


Val Leu Ile Ile His Leu Lys Arg Tyr Ser Phe Asn Asn Ala Trp Leu 
225                 230                 235                 240 


Leu Val Lys Asn Asn Glu Gln Val Tyr Ile Pro Lys Ser Leu Ser Leu 
                245                 250                 255     


Ser Ser Tyr Cys Asn Glu Ser Thr Lys Pro Pro Leu Pro Leu Ser Ser 
            260                 265                 270         


Ser Ala Pro Val Gly Lys Cys Glu Val Leu Glu Val Ser Gln Glu Met 
        275                 280                 285             


Ile Ser Glu Ile Asn Ser Pro Leu Thr Pro Ser Met Lys Leu Thr Ser 
    290                 295                 300                 


Glu Ser Ser Asp Ser Leu Val Leu Pro Val Glu Pro Asp Lys Asn Ala 
305                 310                 315                 320 


Asp Leu Gln Arg Phe Gln Arg Asp Cys Gly Asp Ala Ser Gln Glu Gln 
                325                 330                 335     


His Gln Arg Asp Leu Glu Asn Gly Ser Ala Leu Glu Ser Glu Leu Val 
            340                 345                 350         


His Phe Arg Asp Arg Ala Ile Gly Glu Lys Glu Leu Pro Val Ala Asp 
        355                 360                 365             


Ser Leu Met Asp Gln Gly Asp Ile Ser Leu Pro Val Met Tyr Glu Asp 
    370                 375                 380                 


Gly Gly Lys Leu Ile Ser Ser Pro Asp Thr Arg Leu Val Glu Val His 
385                 390                 395                 400 


Leu Gln Glu Val Pro Gln His Pro Glu Leu Gln Lys Tyr Glu Lys Thr 
                405                 410                 415     


Asn Thr Phe Val Glu Phe Asn Phe Asp Ser Val Thr Glu Ser Thr Asn 
            420                 425                 430         


Gly Phe Tyr Asp Cys Lys Glu Asn Arg Ile Pro Glu Gly Ser Gln Gly 
        435                 440                 445             


Met Ala Glu Gln Leu Gln Gln Cys Ile Glu Glu Ser Ile Ile Asp Glu 
    450                 455                 460                 


Phe Leu Gln Gln Ala Pro Pro Pro Gly Val Arg Lys Leu Asp Ala Gln 
465                 470                 475                 480 


Glu His Thr Glu Glu Thr Leu Asn Gln Ser Thr Glu Leu Arg Leu Gln 
                485                 490                 495     


Lys Ala Asp Leu Asn His Leu Gly Ala Leu Gly Ser Asp Asn Pro Gly 
            500                 505                 510         


Asn Lys Asn Ile Leu Asp Ala Glu Asn Thr Arg Gly Glu Ala Lys Glu 
        515                 520                 525             


Leu Thr Arg Asn Val Lys Met Gly Asp Pro Leu Gln Ala Tyr Arg Leu 
    530                 535                 540                 


Ile Ser Val Val Ser His Ile Gly Ser Ser Pro Asn Ser Gly His Tyr 
545                 550                 555                 560 


Ile Ser Asp Val Tyr Asp Phe Gln Lys Gln Ala Trp Phe Thr Tyr Asn 
                565                 570                 575     


Asp Leu Cys Val Ser Glu Ile Ser Glu Thr Lys Met Gln Glu Ala Arg 
            580                 585                 590         


Leu His Ser Gly Tyr Ile Phe Phe Tyr Met His Asn 
        595                 600                 


<210> 167
<211> 841
<212> PRT
<213> Homo sapiens

<400> 167
Lys Gly Ala Thr Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Met Asn 
1               5                   10                  15      


Ser Ser Ile Gln Cys Val Ser Asn Thr Gln Pro Leu Thr Gln Tyr Phe 
            20                  25                  30          


Ile Ser Gly Arg His Leu Tyr Glu Leu Asn Arg Thr Asn Pro Ile Gly 
        35                  40                  45              


Met Lys Gly His Met Ala Lys Cys Tyr Gly Asp Leu Val Gln Glu Leu 
    50                  55                  60                  


Trp Ser Gly Thr Gln Lys Ser Val Ala Pro Leu Lys Leu Arg Arg Thr 
65                  70                  75                  80  


Ile Ala Lys Tyr Ala Pro Lys Phe Asp Gly Phe Gln Gln Gln Asp Ser 
                85                  90                  95      


Gln Glu Leu Leu Ala Phe Leu Leu Asp Gly Leu His Glu Asp Leu Asn 
            100                 105                 110         


Arg Val His Glu Lys Pro Tyr Val Glu Leu Lys Asp Ser Asp Gly Arg 
        115                 120                 125             


Pro Asp Trp Glu Val Ala Ala Glu Ala Trp Asp Asn His Leu Arg Arg 
    130                 135                 140                 


Asn Arg Ser Ile Ile Val Asp Leu Phe His Gly Gln Leu Arg Ser Gln 
145                 150                 155                 160 


Val Lys Cys Lys Thr Cys Gly His Ile Ser Val Arg Phe Asp Pro Asn 
                165                 170                 175     


Phe Leu Ser Leu Pro Leu Pro Met Asp Ser Tyr Met Asp Leu Glu Ile 
            180                 185                 190         


Thr Val Ile Lys Leu Asp Gly Thr Thr Pro Val Arg Tyr Gly Leu Arg 
        195                 200                 205             


Leu Asn Met Asp Glu Lys Tyr Thr Gly Leu Lys Lys Gln Leu Arg Asp 
    210                 215                 220                 


Leu Cys Gly Leu Asn Ser Glu Gln Ile Leu Leu Ala Glu Val His Asp 
225                 230                 235                 240 


Ser Asn Ile Lys Asn Phe Pro Gln Asp Asn Gln Lys Val Gln Leu Ser 
                245                 250                 255     


Val Ser Gly Phe Leu Cys Ala Phe Glu Ile Pro Val Pro Ser Ser Pro 
            260                 265                 270         


Ile Ser Ala Ser Ser Pro Thr Gln Ile Asp Phe Ser Ser Ser Pro Ser 
        275                 280                 285             


Thr Asn Gly Met Phe Thr Leu Thr Thr Asn Gly Asp Leu Pro Lys Pro 
    290                 295                 300                 


Ile Phe Ile Pro Asn Gly Met Pro Asn Thr Val Val Pro Cys Gly Thr 
305                 310                 315                 320 


Glu Lys Asn Phe Thr Asn Gly Met Val Asn Gly His Met Pro Ser Leu 
                325                 330                 335     


Pro Asp Ser Pro Phe Thr Gly Tyr Ile Ile Ala Val His Arg Lys Met 
            340                 345                 350         


Met Arg Thr Glu Leu Tyr Phe Leu Ser Pro Gln Glu Asn Arg Pro Ser 
        355                 360                 365             


Leu Phe Gly Met Pro Leu Ile Val Pro Cys Thr Val His Thr Arg Lys 
    370                 375                 380                 


Lys Asp Leu Tyr Asp Ala Val Trp Ile Gln Val Ser Trp Leu Ala Arg 
385                 390                 395                 400 


Pro Leu Pro Pro Gln Glu Ala Ser Ile His Ala Gln Asp Arg Asp Asn 
                405                 410                 415     


Cys Met Gly Tyr Gln Tyr Pro Phe Thr Leu Arg Val Val Gln Lys Asp 
            420                 425                 430         


Gly Asn Ser Cys Ala Trp Cys Pro Gln Tyr Arg Phe Cys Arg Gly Cys 
        435                 440                 445             


Lys Ile Asp Cys Gly Glu Asp Arg Ala Phe Ile Gly Asn Ala Tyr Ile 
    450                 455                 460                 


Ala Val Asp Trp His Pro Thr Ala Leu His Leu Arg Tyr Gln Thr Ser 
465                 470                 475                 480 


Gln Glu Arg Val Val Asp Lys His Glu Ser Val Glu Gln Ser Arg Arg 
                485                 490                 495     


Ala Gln Ala Glu Pro Ile Asn Leu Asp Ser Cys Leu Arg Ala Phe Thr 
            500                 505                 510         


Ser Glu Glu Glu Leu Gly Glu Ser Glu Met Tyr Tyr Cys Ser Lys Cys 
        515                 520                 525             


Lys Thr His Cys Leu Ala Thr Lys Lys Leu Asp Leu Trp Arg Leu Pro 
    530                 535                 540                 


Pro Phe Leu Ile Ile His Leu Lys Arg Phe Gln Phe Val Asn Asp Gln 
545                 550                 555                 560 


Trp Ile Lys Ser Gln Lys Ile Val Arg Phe Leu Arg Glu Ser Phe Asp 
                565                 570                 575     


Pro Ser Ala Phe Leu Val Pro Arg Asp Pro Ala Leu Cys Gln His Lys 
            580                 585                 590         


Pro Leu Thr Pro Gln Gly Asp Glu Leu Ser Lys Pro Arg Ile Leu Ala 
        595                 600                 605             


Arg Glu Val Lys Lys Val Asp Ala Gln Ser Ser Ala Gly Lys Glu Asp 
    610                 615                 620                 


Met Leu Leu Ser Lys Ser Pro Ser Ser Leu Ser Ala Asn Ile Ser Ser 
625                 630                 635                 640 


Ser Pro Lys Gly Ser Pro Ser Ser Ser Arg Lys Ser Gly Thr Ser Cys 
                645                 650                 655     


Pro Ser Ser Lys Asn Ser Ser Pro Asn Ser Ser Pro Arg Thr Leu Gly 
            660                 665                 670         


Arg Ser Lys Gly Arg Leu Arg Leu Pro Gln Ile Gly Ser Lys Asn Lys 
        675                 680                 685             


Pro Ser Ser Ser Lys Lys Asn Leu Asp Ala Ser Lys Glu Asn Gly Ala 
    690                 695                 700                 


Gly Gln Ile Cys Glu Leu Ala Asp Ala Leu Ser Arg Gly His Met Arg 
705                 710                 715                 720 


Gly Gly Ser Gln Pro Glu Leu Val Thr Pro Gln Asp His Glu Val Ala 
                725                 730                 735     


Leu Ala Asn Gly Phe Leu Tyr Glu His Glu Ala Cys Gly Asn Gly Cys 
            740                 745                 750         


Gly Asp Gly Tyr Ser Asn Gly Gln Leu Gly Asn His Ser Glu Glu Asp 
        755                 760                 765             


Ser Thr Asp Asp Gln Arg Glu Asp Thr His Ile Lys Pro Ile Tyr Asn 
    770                 775                 780                 


Leu Tyr Ala Ile Ser Cys His Ser Gly Ile Leu Ser Gly Gly His Tyr 
785                 790                 795                 800 


Ile Thr Tyr Ala Lys Asn Pro Asn Cys Lys Trp Tyr Cys Tyr Asn Asp 
                805                 810                 815     


Ser Ser Cys Glu Glu Leu His Pro Asp Glu Ile Asp Thr Asp Ser Ala 
            820                 825                 830         


Tyr Ile Leu Phe Tyr Glu Gln Gln Gly 
        835                 840     


<210> 168
<211> 446
<212> PRT
<213> Homo sapiens

<400> 168
Ala Pro Thr Lys Gly Leu Leu Asn Glu Pro Gly Gln Asn Ser Cys Phe 
1               5                   10                  15      


Leu Asn Ser Ala Val Gln Val Leu Trp Gln Leu Asp Ile Phe Arg Arg 
            20                  25                  30          


Ser Leu Arg Val Leu Thr Gly His Val Cys Gln Gly Asp Ala Cys Ile 
        35                  40                  45              


Phe Cys Ala Leu Lys Thr Ile Phe Ala Gln Phe Gln His Ser Arg Glu 
    50                  55                  60                  


Lys Ala Leu Pro Ser Asp Asn Ile Arg His Ala Leu Ala Glu Ser Phe 
65                  70                  75                  80  


Lys Asp Glu Gln Arg Phe Gln Leu Gly Leu Met Asp Asp Ala Ala Glu 
                85                  90                  95      


Cys Phe Glu Asn Met Leu Glu Arg Ile His Phe His Ile Val Pro Ser 
            100                 105                 110         


Arg Asp Ala Asp Met Cys Thr Ser Lys Ser Cys Ile Thr His Gln Lys 
        115                 120                 125             


Phe Ala Met Thr Leu Tyr Glu Gln Cys Val Cys Arg Ser Cys Gly Ala 
    130                 135                 140                 


Ser Ser Asp Pro Leu Pro Phe Thr Glu Phe Val Arg Tyr Ile Ser Thr 
145                 150                 155                 160 


Thr Ala Leu Cys Asn Glu Val Glu Arg Met Leu Glu Arg His Glu Arg 
                165                 170                 175     


Phe Lys Pro Glu Met Phe Ala Glu Leu Leu Gln Ala Ala Asn Thr Thr 
            180                 185                 190         


Asp Asp Tyr Arg Lys Cys Pro Ser Asn Cys Gly Gln Lys Ile Lys Ile 
        195                 200                 205             


Arg Arg Val Leu Met Asn Cys Pro Glu Ile Val Thr Ile Gly Leu Val 
    210                 215                 220                 


Trp Asp Ser Glu His Ser Asp Leu Thr Glu Ala Val Val Arg Asn Leu 
225                 230                 235                 240 


Ala Thr His Leu Tyr Leu Pro Gly Leu Phe Tyr Arg Val Thr Asp Glu 
                245                 250                 255     


Asn Ala Lys Asn Ser Glu Leu Asn Leu Val Gly Met Ile Cys Tyr Thr 
            260                 265                 270         


Ser Gln His Tyr Cys Ala Phe Ala Phe His Thr Lys Ser Ser Lys Trp 
        275                 280                 285             


Val Phe Phe Asp Asp Ala Asn Val Lys Glu Ile Gly Thr Arg Trp Lys 
    290                 295                 300                 


Asp Val Val Ser Lys Cys Ile Arg Cys His Phe Gln Pro Leu Leu Leu 
305                 310                 315                 320 


Phe Tyr Ala Asn Pro Asp Gly Thr Ala Val Ser Thr Glu Asp Ala Leu 
                325                 330                 335     


Arg Gln Val Ile Ser Trp Ser His Tyr Lys Ser Val Ala Glu Asn Met 
            340                 345                 350         


Gly Cys Glu Lys Pro Val Ile His Lys Ser Asp Asn Leu Lys Glu Asn 
        355                 360                 365             


Gly Phe Gly Asp Gln Ala Lys Gln Arg Glu Asn Gln Lys Phe Pro Thr 
    370                 375                 380                 


Asp Asn Ile Ser Ser Ser Asn Arg Ser His Ser His Thr Gly Val Gly 
385                 390                 395                 400 


Lys Gly Pro Ala Lys Leu Ser His Ile Asp Gln Arg Glu Lys Ile Lys 
                405                 410                 415     


Asp Ile Ser Arg Glu Cys Ala Leu Lys Ala Ile Glu Gln Lys Asn Leu 
            420                 425                 430         


Leu Ser Ser Gln Arg Lys Asp Leu Glu Lys Gly Gln Arg Lys 
        435                 440                 445     


<210> 169
<211> 600
<212> PRT
<213> Homo sapiens

<400> 169
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser Ala Val Gly Ala 
    290                 295                 300                 


Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn Ala Ser Leu Gln 
305                 310                 315                 320 


Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met Leu Ser Arg Glu 
                325                 330                 335     


His Ser Gln Thr Cys His Arg His Lys Gly Cys Met Leu Cys Thr Met 
            340                 345                 350         


Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly His Val Ile Gln 
        355                 360                 365             


Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly Lys Gln Glu Asp 
    370                 375                 380                 


Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met Lys Lys Ala Cys 
385                 390                 395                 400 


Leu Pro Gly His Lys Gln Val Asp His His Ser Lys Asp Thr Thr Leu 
                405                 410                 415     


Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln Ile Lys Cys Leu 
            420                 425                 430         


His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr Leu Asp Ile Ala 
        435                 440                 445             


Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala Leu Glu Gln Leu 
    450                 455                 460                 


Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr His Cys Gly Val 
465                 470                 475                 480 


Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr Leu His Thr Ser 
                485                 490                 495     


Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser Asp Val Thr Gly 
            500                 505                 510         


Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys Leu Asp Met Gln 
        515                 520                 525             


Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val Tyr Val Leu Tyr 
    530                 535                 540                 


Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn Gly His Tyr Phe 
545                 550                 555                 560 


Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys Met Asp Asp Ala 
                565                 570                 575     


Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser Gln Gln Ala Tyr 
            580                 585                 590         


Val Leu Phe Tyr Ile Gln Lys Ser 
        595                 600 


<210> 170
<211> 1020
<212> PRT
<213> Homo sapiens

<400> 170
Phe Gly Pro Gly Tyr Thr Gly Ile Arg Asn Leu Gly Asn Ser Cys Tyr 
1               5                   10                  15      


Leu Asn Ser Val Val Gln Val Leu Phe Ser Ile Pro Asp Phe Gln Arg 
            20                  25                  30          


Lys Tyr Val Asp Lys Leu Glu Lys Ile Phe Gln Asn Ala Pro Thr Asp 
        35                  40                  45              


Pro Thr Gln Asp Phe Ser Thr Gln Val Ala Lys Leu Gly His Gly Leu 
    50                  55                  60                  


Leu Ser Gly Glu Tyr Ser Lys Pro Val Pro Glu Ser Gly Asp Gly Glu 
65                  70                  75                  80  


Arg Val Pro Glu Gln Lys Glu Val Gln Asp Gly Ile Ala Pro Arg Met 
                85                  90                  95      


Phe Lys Ala Leu Ile Gly Lys Gly His Pro Glu Phe Ser Thr Asn Arg 
            100                 105                 110         


Gln Gln Asp Ala Gln Glu Phe Phe Leu His Leu Ile Asn Met Val Glu 
        115                 120                 125             


Arg Asn Cys Arg Ser Ser Glu Asn Pro Asn Glu Val Phe Arg Phe Leu 
    130                 135                 140                 


Val Glu Glu Lys Ile Lys Cys Leu Ala Thr Glu Lys Val Lys Tyr Thr 
145                 150                 155                 160 


Gln Arg Val Asp Tyr Ile Met Gln Leu Pro Val Pro Met Asp Ala Ala 
                165                 170                 175     


Leu Asn Lys Glu Glu Leu Leu Glu Tyr Glu Glu Lys Lys Arg Gln Ala 
            180                 185                 190         


Glu Glu Glu Lys Met Ala Leu Pro Glu Leu Val Arg Ala Gln Val Pro 
        195                 200                 205             


Phe Ser Ser Cys Leu Glu Ala Tyr Gly Ala Pro Glu Gln Val Asp Asp 
    210                 215                 220                 


Phe Trp Ser Thr Ala Leu Gln Ala Lys Ser Val Ala Val Lys Thr Thr 
225                 230                 235                 240 


Arg Phe Ala Ser Phe Pro Asp Tyr Leu Val Ile Gln Ile Lys Lys Phe 
                245                 250                 255     


Thr Phe Gly Leu Asp Trp Val Pro Lys Lys Leu Asp Val Ser Ile Glu 
            260                 265                 270         


Met Pro Glu Glu Leu Asp Ile Ser Gln Leu Arg Gly Thr Gly Leu Gln 
        275                 280                 285             


Pro Gly Glu Glu Glu Leu Pro Asp Ile Ala Pro Pro Leu Val Thr Pro 
    290                 295                 300                 


Asp Glu Pro Lys Gly Ser Leu Gly Phe Tyr Gly Asn Glu Asp Glu Asp 
305                 310                 315                 320 


Ser Phe Cys Ser Pro His Phe Ser Ser Pro Thr Ser Pro Met Leu Asp 
                325                 330                 335     


Glu Ser Val Ile Ile Gln Leu Val Glu Met Gly Phe Pro Met Asp Ala 
            340                 345                 350         


Cys Arg Lys Ala Val Tyr Tyr Thr Gly Asn Ser Gly Ala Glu Ala Ala 
        355                 360                 365             


Met Asn Trp Val Met Ser His Met Asp Asp Pro Asp Phe Ala Asn Pro 
    370                 375                 380                 


Leu Ile Leu Pro Gly Ser Ser Gly Pro Gly Ser Thr Ser Ala Ala Ala 
385                 390                 395                 400 


Asp Pro Pro Pro Glu Asp Cys Val Thr Thr Ile Val Ser Met Gly Phe 
                405                 410                 415     


Ser Arg Asp Gln Ala Leu Lys Ala Leu Arg Ala Thr Asn Asn Ser Leu 
            420                 425                 430         


Glu Arg Ala Val Asp Trp Ile Phe Ser His Ile Asp Asp Leu Asp Ala 
        435                 440                 445             


Glu Ala Ala Met Asp Ile Ser Glu Gly Arg Ser Ala Ala Asp Ser Ile 
    450                 455                 460                 


Ser Glu Ser Val Pro Val Gly Pro Lys Val Arg Asp Gly Pro Gly Lys 
465                 470                 475                 480 


Tyr Gln Leu Phe Ala Phe Ile Ser His Met Gly Thr Ser Thr Met Cys 
                485                 490                 495     


Gly His Tyr Val Cys His Ile Lys Lys Glu Gly Arg Trp Val Ile Tyr 
            500                 505                 510         


Asn Asp Gln Lys Val Cys Ala Ser Glu Lys Pro Pro Lys Asp Leu Gly 
        515                 520                 525             


Tyr Ile Tyr Phe Tyr Gln Arg Val Ala Lys Ala Pro Val Gly Leu Lys 
    530                 535                 540                 


Asn Val Gly Asn Thr Cys Trp Phe Ser Ala Val Ile Gln Ser Leu Phe 
545                 550                 555                 560 


Asn Leu Leu Glu Phe Arg Arg Leu Val Leu Asn Tyr Lys Pro Pro Ser 
                565                 570                 575     


Asn Ala Gln Asp Leu Pro Arg Asn Gln Lys Glu His Arg Asn Leu Pro 
            580                 585                 590         


Phe Met Arg Glu Leu Arg Tyr Leu Phe Ala Leu Leu Val Gly Thr Lys 
        595                 600                 605             


Arg Lys Tyr Val Asp Pro Ser Arg Ala Val Glu Ile Leu Lys Asp Ala 
    610                 615                 620                 


Phe Lys Ser Asn Asp Ser Gln Gln Gln Asp Val Ser Glu Phe Thr His 
625                 630                 635                 640 


Lys Leu Leu Asp Trp Leu Glu Asp Ala Phe Gln Met Lys Ala Glu Glu 
                645                 650                 655     


Glu Thr Asp Glu Glu Lys Pro Lys Asn Pro Met Val Glu Leu Phe Tyr 
            660                 665                 670         


Gly Arg Phe Leu Ala Val Gly Val Leu Glu Gly Lys Lys Phe Glu Asn 
        675                 680                 685             


Thr Glu Met Phe Gly Gln Tyr Pro Leu Gln Val Asn Gly Phe Lys Asp 
    690                 695                 700                 


Leu His Glu Cys Leu Glu Ala Ala Met Ile Glu Gly Glu Ile Glu Ser 
705                 710                 715                 720 


Leu His Ser Glu Asn Ser Gly Lys Ser Gly Gln Glu His Trp Phe Thr 
                725                 730                 735     


Glu Leu Pro Pro Val Leu Thr Phe Glu Leu Ser Arg Phe Glu Phe Asn 
            740                 745                 750         


Gln Ala Leu Gly Arg Pro Glu Lys Ile His Asn Lys Leu Glu Phe Pro 
        755                 760                 765             


Gln Val Leu Tyr Leu Asp Arg Tyr Met His Arg Asn Arg Glu Ile Thr 
    770                 775                 780                 


Arg Ile Lys Arg Glu Glu Ile Lys Arg Leu Lys Asp Tyr Leu Thr Val 
785                 790                 795                 800 


Leu Gln Gln Arg Leu Glu Arg Tyr Leu Ser Tyr Gly Ser Gly Pro Lys 
                805                 810                 815     


Arg Phe Pro Leu Val Asp Val Leu Gln Tyr Ala Leu Glu Phe Ala Ser 
            820                 825                 830         


Ser Lys Pro Val Cys Thr Ser Pro Val Asp Asp Ile Asp Ala Ser Ser 
        835                 840                 845             


Pro Pro Ser Gly Ser Ile Pro Ser Gln Thr Leu Pro Ser Thr Thr Glu 
    850                 855                 860                 


Gln Gln Gly Ala Leu Ser Ser Glu Leu Pro Ser Thr Ser Pro Ser Ser 
865                 870                 875                 880 


Val Ala Ala Ile Ser Ser Arg Ser Val Ile His Lys Pro Phe Thr Gln 
                885                 890                 895     


Ser Arg Ile Pro Pro Asp Leu Pro Met His Pro Ala Pro Arg His Ile 
            900                 905                 910         


Thr Glu Glu Glu Leu Ser Val Leu Glu Ser Cys Leu His Arg Trp Arg 
        915                 920                 925             


Thr Glu Ile Glu Asn Asp Thr Arg Asp Leu Gln Glu Ser Ile Ser Arg 
    930                 935                 940                 


Ile His Arg Thr Ile Glu Leu Met Tyr Ser Asp Lys Ser Met Ile Gln 
945                 950                 955                 960 


Val Pro Tyr Arg Leu His Ala Val Leu Val His Glu Gly Gln Ala Asn 
                965                 970                 975     


Ala Gly His Tyr Trp Ala Tyr Ile Phe Asp His Arg Glu Ser Arg Trp 
            980                 985                 990         


Met Lys Tyr Asn Asp Ile Ala Val  Thr Lys Ser Ser Trp  Glu Glu Leu 
        995                 1000                 1005             


Val Arg  Asp Ser Phe Gly Gly  Tyr Arg Asn Ala Ser  
    1010                 1015                 1020 


<210> 171
<211> 536
<212> PRT
<213> Homo sapiens

<400> 171
Ala Arg Gly Leu Thr Gly Leu Lys Asn Ile Gly Asn Thr Cys Tyr Met 
1               5                   10                  15      


Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe 
            20                  25                  30          


Phe Leu Asp Cys Gly Gly Leu Ala Arg Thr Asp Lys Lys Pro Ala Ile 
        35                  40                  45              


Cys Lys Ser Tyr Leu Lys Leu Met Thr Glu Leu Trp His Lys Ser Arg 
    50                  55                  60                  


Pro Gly Ser Val Val Pro Thr Thr Leu Phe Gln Gly Ile Lys Thr Val 
65                  70                  75                  80  


Asn Pro Thr Phe Arg Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe Leu 
                85                  90                  95      


Arg Cys Leu Met Asp Leu Leu His Glu Glu Leu Lys Glu Gln Val Met 
            100                 105                 110         


Glu Val Glu Glu Asp Pro Gln Thr Ile Thr Thr Glu Glu Thr Met Glu 
        115                 120                 125             


Glu Asp Lys Ser Gln Ser Asp Val Asp Phe Gln Ser Cys Glu Ser Cys 
    130                 135                 140                 


Ser Asn Ser Asp Arg Ala Glu Asn Glu Asn Gly Ser Arg Cys Phe Ser 
145                 150                 155                 160 


Glu Asp Asn Asn Glu Thr Thr Met Leu Ile Gln Asp Asp Glu Asn Asn 
                165                 170                 175     


Ser Glu Met Ser Lys Asp Trp Gln Lys Glu Lys Met Cys Asn Lys Ile 
            180                 185                 190         


Asn Lys Val Asn Ser Glu Gly Glu Phe Asp Lys Asp Arg Asp Ser Ile 
        195                 200                 205             


Ser Glu Thr Val Asp Leu Asn Asn Gln Glu Thr Val Lys Val Gln Ile 
    210                 215                 220                 


His Ser Arg Ala Ser Glu Tyr Ile Thr Asp Val His Ser Asn Asp Leu 
225                 230                 235                 240 


Ser Thr Pro Gln Ile Leu Pro Ser Asn Glu Gly Val Asn Pro Arg Leu 
                245                 250                 255     


Ser Ala Ser Pro Pro Lys Ser Gly Asn Leu Trp Pro Gly Leu Ala Pro 
            260                 265                 270         


Pro His Lys Lys Ala Gln Ser Ala Ser Pro Lys Arg Lys Lys Gln His 
        275                 280                 285             


Lys Lys Tyr Arg Ser Val Ile Ser Asp Ile Phe Asp Gly Thr Ile Ile 
    290                 295                 300                 


Ser Ser Val Gln Cys Leu Thr Cys Asp Arg Val Ser Val Thr Leu Glu 
305                 310                 315                 320 


Thr Phe Gln Asp Leu Ser Leu Pro Ile Pro Gly Lys Glu Asp Leu Ala 
                325                 330                 335     


Lys Leu His Ser Ser Ser His Pro Thr Ser Ile Val Lys Ala Gly Ser 
            340                 345                 350         


Cys Gly Glu Ala Tyr Ala Pro Gln Gly Trp Ile Ala Phe Phe Met Glu 
        355                 360                 365             


Tyr Val Lys Arg Phe Val Val Ser Cys Val Pro Ser Trp Phe Trp Gly 
    370                 375                 380                 


Pro Val Val Thr Leu Gln Asp Cys Leu Ala Ala Phe Phe Ala Arg Asp 
385                 390                 395                 400 


Glu Leu Lys Gly Asp Asn Met Tyr Ser Cys Glu Lys Cys Lys Lys Leu 
                405                 410                 415     


Arg Asn Gly Val Lys Phe Cys Lys Val Gln Asn Phe Pro Glu Ile Leu 
            420                 425                 430         


Cys Ile His Leu Lys Arg Phe Arg His Glu Leu Met Phe Ser Thr Lys 
        435                 440                 445             


Ile Ser Thr His Val Ser Phe Pro Leu Glu Gly Leu Asp Leu Gln Pro 
    450                 455                 460                 


Phe Leu Ala Lys Asp Ser Pro Ala Gln Ile Val Thr Tyr Asp Leu Leu 
465                 470                 475                 480 


Ser Val Ile Cys His His Gly Thr Ala Ser Ser Gly His Tyr Ile Ala 
                485                 490                 495     


Tyr Cys Arg Asn Asn Leu Asn Asn Leu Trp Tyr Glu Phe Asp Asp Gln 
            500                 505                 510         


Ser Val Thr Glu Val Ser Glu Ser Thr Val Gln Asn Ala Glu Ala Tyr 
        515                 520                 525             


Val Leu Phe Tyr Arg Lys Ser Ser 
    530                 535     


<210> 172
<211> 353
<212> PRT
<213> Homo sapiens

<400> 172
Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
1               5                   10                  15      


Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp 
            20                  25                  30          


Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg 
        35                  40                  45              


Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp 
    50                  55                  60                  


His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val 
65                  70                  75                  80  


Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala 
                85                  90                  95      


Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn 
            100                 105                 110         


Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro 
        115                 120                 125             


Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser 
    130                 135                 140                 


Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu 
145                 150                 155                 160 


Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu 
                165                 170                 175     


Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys 
            180                 185                 190         


Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val 
        195                 200                 205             


Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu 
    210                 215                 220                 


Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser 
225                 230                 235                 240 


Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His 
                245                 250                 255     


Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val 
            260                 265                 270         


Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser 
        275                 280                 285             


Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His 
    290                 295                 300                 


Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln 
305                 310                 315                 320 


Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu 
                325                 330                 335     


Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met 
            340                 345                 350         


Gln 
    


<210> 173
<211> 300
<212> PRT
<213> Homo sapiens

<400> 173
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Glu Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Leu Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys Gln Arg Pro Lys Cys Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Trp Ala Leu His Ser Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Val His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Cys Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Lys Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Leu Cys Leu Gln Arg Ala Pro Ala Ser Asn Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Ala Gly Asn Lys Leu Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Gln Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asp 
                245                 250                 255     


Gly Tyr Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Val Cys Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 174
<211> 300
<212> PRT
<213> Homo sapiens

<400> 174
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Thr Leu Thr 
            180                 185                 190         


Leu His Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 175
<211> 334
<212> PRT
<213> Homo sapiens

<400> 175
Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn 
1               5                   10                  15      


Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Lys Val 
            20                  25                  30          


Leu Ala Tyr Lys Ser Gln Pro Arg Lys Lys Glu Ser Leu Leu Thr Cys 
        35                  40                  45              


Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly 
    50                  55                  60                  


Val Ile Pro Pro Lys Lys Phe Ile Thr Arg Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr 
                85                  90                  95      


Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Arg Lys Gln Glu 
            100                 105                 110         


Lys Gln Asn Gly Arg Leu Pro Asn Gly Asn Ile Asp Asn Glu Asn Asn 
        115                 120                 125             


Asn Ser Thr Pro Asp Pro Thr Trp Val His Glu Ile Phe Gln Gly Thr 
    130                 135                 140                 


Leu Thr Asn Glu Thr Arg Cys Leu Thr Cys Glu Thr Ile Ser Ser Lys 
145                 150                 155                 160 


Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser 
                165                 170                 175     


Ile Thr His Cys Leu Arg Gly Phe Ser Asn Thr Glu Thr Leu Cys Ser 
            180                 185                 190         


Glu Tyr Lys Tyr Tyr Cys Glu Glu Cys Arg Ser Lys Gln Glu Ala His 
        195                 200                 205             


Lys Arg Met Lys Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu 
    210                 215                 220                 


Lys Arg Phe Lys Tyr Met Asp Gln Leu His Arg Tyr Thr Lys Leu Ser 
225                 230                 235                 240 


Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Gly 
                245                 250                 255     


Asp Ala Thr Asn Pro Asp Arg Met Tyr Asp Leu Val Ala Val Val Val 
            260                 265                 270         


His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Ala Ile Val Lys 
        275                 280                 285             


Ser His Asp Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile 
    290                 295                 300                 


Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser 
305                 310                 315                 320 


Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg 
                325                 330                 


<210> 176
<211> 300
<212> PRT
<213> Homo sapiens

<400> 176
Ala Val Gly Ala Gly Leu Gln Asn Met Gly Asn Thr Cys Tyr Val Asn 
1               5                   10                  15      


Ala Ser Leu Gln Cys Leu Thr Tyr Thr Pro Pro Leu Ala Asn Tyr Met 
            20                  25                  30          


Leu Ser Arg Glu His Ser Gln Thr Cys His Arg His Lys Gly Cys Met 
        35                  40                  45              


Leu Cys Thr Met Gln Ala His Ile Thr Arg Ala Leu His Asn Pro Gly 
    50                  55                  60                  


His Val Ile Gln Pro Ser Gln Ala Leu Ala Ala Gly Phe His Arg Gly 
65                  70                  75                  80  


Lys Gln Glu Asp Ala His Glu Phe Leu Met Phe Thr Val Asp Ala Met 
                85                  90                  95      


Lys Lys Ala Cys Leu Pro Gly His Lys Gln Val Asp His His Ser Lys 
            100                 105                 110         


Asp Thr Thr Leu Ile His Gln Ile Phe Gly Gly Tyr Trp Arg Ser Gln 
        115                 120                 125             


Ile Lys Cys Leu His Cys His Gly Ile Ser Asp Thr Phe Asp Pro Tyr 
    130                 135                 140                 


Leu Asp Ile Ala Leu Asp Ile Gln Ala Ala Gln Ser Val Gln Gln Ala 
145                 150                 155                 160 


Leu Glu Gln Leu Val Lys Pro Glu Glu Leu Asn Gly Glu Asn Ala Tyr 
                165                 170                 175     


His Cys Gly Val Cys Leu Gln Arg Ala Pro Ala Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Leu Thr Ser Ala Lys Val Leu Ile Leu Val Leu Lys Arg Phe Ser 
        195                 200                 205             


Asp Val Thr Gly Asn Lys Ile Ala Lys Asn Val Gln Tyr Pro Glu Cys 
    210                 215                 220                 


Leu Asp Met Gln Pro Tyr Met Ser Gln Pro Asn Thr Gly Pro Leu Val 
225                 230                 235                 240 


Tyr Val Leu Tyr Ala Val Leu Val His Ala Gly Trp Ser Cys His Asn 
                245                 250                 255     


Gly His Tyr Phe Ser Tyr Val Lys Ala Gln Glu Gly Gln Trp Tyr Lys 
            260                 265                 270         


Met Asp Asp Ala Glu Val Thr Ala Ser Ser Ile Thr Ser Val Leu Ser 
        275                 280                 285             


Gln Gln Ala Tyr Val Leu Phe Tyr Ile Gln Lys Ser 
    290                 295                 300 


<210> 177
<211> 546
<212> PRT
<213> Homo sapiens

<400> 177
Pro Arg Gly Leu Thr Gly Met Lys Asn Leu Gly Asn Ser Cys Tyr Met 
1               5                   10                  15      


Asn Ala Ala Leu Gln Ala Leu Ser Asn Cys Pro Pro Leu Thr Gln Phe 
            20                  25                  30          


Phe Leu Glu Cys Gly Gly Leu Val Arg Thr Asp Lys Lys Pro Ala Leu 
        35                  40                  45              


Cys Lys Ser Tyr Gln Lys Leu Val Ser Glu Val Trp His Lys Lys Arg 
    50                  55                  60                  


Pro Ser Tyr Val Val Pro Thr Ser Leu Ser His Gly Ile Lys Leu Val 
65                  70                  75                  80  


Asn Pro Met Phe Arg Gly Tyr Ala Gln Gln Asp Thr Gln Glu Phe Leu 
                85                  90                  95      


Arg Cys Leu Met Asp Gln Leu His Glu Glu Leu Lys Glu Pro Val Val 
            100                 105                 110         


Ala Thr Val Ala Leu Thr Glu Ala Arg Asp Ser Asp Ser Ser Asp Thr 
        115                 120                 125             


Asp Glu Lys Arg Glu Gly Asp Arg Ser Pro Ser Glu Asp Glu Phe Leu 
    130                 135                 140                 


Ser Cys Asp Ser Ser Ser Asp Arg Gly Glu Gly Asp Gly Gln Gly Arg 
145                 150                 155                 160 


Gly Gly Gly Ser Ser Gln Ala Glu Thr Glu Leu Leu Ile Pro Asp Glu 
                165                 170                 175     


Ala Gly Arg Ala Ile Ser Glu Lys Glu Arg Met Lys Asp Arg Lys Phe 
            180                 185                 190         


Ser Trp Gly Gln Gln Arg Thr Asn Ser Glu Gln Val Asp Glu Asp Ala 
        195                 200                 205             


Asp Val Asp Thr Ala Met Ala Ala Leu Asp Asp Gln Pro Ala Glu Ala 
    210                 215                 220                 


Gln Pro Pro Ser Pro Arg Ser Ser Ser Pro Cys Arg Thr Pro Glu Pro 
225                 230                 235                 240 


Asp Asn Asp Ala His Leu Arg Ser Ser Ser Arg Pro Cys Ser Pro Val 
                245                 250                 255     


His His His Glu Gly His Ala Lys Leu Ser Ser Ser Pro Pro Arg Ala 
            260                 265                 270         


Ser Pro Val Arg Met Ala Pro Ser Tyr Val Leu Lys Lys Ala Gln Val 
        275                 280                 285             


Leu Ser Ala Gly Ser Arg Arg Arg Lys Glu Gln Arg Tyr Arg Ser Val 
    290                 295                 300                 


Ile Ser Asp Ile Phe Asp Gly Ser Ile Leu Ser Leu Val Gln Cys Leu 
305                 310                 315                 320 


Thr Cys Asp Arg Val Ser Thr Thr Val Glu Thr Phe Gln Asp Leu Ser 
                325                 330                 335     


Leu Pro Ile Pro Gly Lys Glu Asp Leu Ala Lys Leu His Ser Ala Ile 
            340                 345                 350         


Tyr Gln Asn Val Pro Ala Lys Pro Gly Ala Cys Gly Asp Ser Tyr Ala 
        355                 360                 365             


Ala Gln Gly Trp Leu Ala Phe Ile Val Glu Tyr Ile Arg Arg Phe Val 
    370                 375                 380                 


Val Ser Cys Thr Pro Ser Trp Phe Trp Gly Pro Val Val Thr Leu Glu 
385                 390                 395                 400 


Asp Cys Leu Ala Ala Phe Phe Ala Ala Asp Glu Leu Lys Gly Asp Asn 
                405                 410                 415     


Met Tyr Ser Cys Glu Arg Cys Lys Lys Leu Arg Asn Gly Val Lys Tyr 
            420                 425                 430         


Cys Lys Val Leu Arg Leu Pro Glu Ile Leu Cys Ile His Leu Lys Arg 
        435                 440                 445             


Phe Arg His Glu Val Met Tyr Ser Phe Lys Ile Asn Ser His Val Ser 
    450                 455                 460                 


Phe Pro Leu Glu Gly Leu Asp Leu Arg Pro Phe Leu Ala Lys Glu Cys 
465                 470                 475                 480 


Thr Ser Gln Ile Thr Thr Tyr Asp Leu Leu Ser Val Ile Cys His His 
                485                 490                 495     


Gly Thr Ala Gly Ser Gly His Tyr Ile Ala Tyr Cys Gln Asn Val Ile 
            500                 505                 510         


Asn Gly Gln Trp Tyr Glu Phe Asp Asp Gln Tyr Val Thr Glu Val His 
        515                 520                 525             


Glu Thr Val Val Gln Asn Ala Glu Gly Tyr Val Leu Phe Tyr Arg Lys 
    530                 535                 540                 


Ser Ser 
545     


<210> 178
<211> 334
<212> PRT
<213> Homo sapiens

<400> 178
Glu His Tyr Phe Gly Leu Val Asn Phe Gly Asn Thr Cys Tyr Cys Asn 
1               5                   10                  15      


Ser Val Leu Gln Ala Leu Tyr Phe Cys Arg Pro Phe Arg Glu Asn Val 
            20                  25                  30          


Leu Ala Tyr Lys Ala Gln Gln Lys Lys Lys Glu Asn Leu Leu Thr Cys 
        35                  40                  45              


Leu Ala Asp Leu Phe His Ser Ile Ala Thr Gln Lys Lys Lys Val Gly 
    50                  55                  60                  


Val Ile Pro Pro Lys Lys Phe Ile Ser Arg Leu Arg Lys Glu Asn Asp 
65                  70                  75                  80  


Leu Phe Asp Asn Tyr Met Gln Gln Asp Ala His Glu Phe Leu Asn Tyr 
                85                  90                  95      


Leu Leu Asn Thr Ile Ala Asp Ile Leu Gln Glu Glu Lys Lys Gln Glu 
            100                 105                 110         


Lys Gln Asn Gly Lys Leu Lys Asn Gly Asn Met Asn Glu Pro Ala Glu 
        115                 120                 125             


Asn Asn Lys Pro Glu Leu Thr Trp Val His Glu Ile Phe Gln Gly Thr 
    130                 135                 140                 


Leu Thr Asn Glu Thr Arg Cys Leu Asn Cys Glu Thr Val Ser Ser Lys 
145                 150                 155                 160 


Asp Glu Asp Phe Leu Asp Leu Ser Val Asp Val Glu Gln Asn Thr Ser 
                165                 170                 175     


Ile Thr His Cys Leu Arg Asp Phe Ser Asn Thr Glu Thr Leu Cys Ser 
            180                 185                 190         


Glu Gln Lys Tyr Tyr Cys Glu Thr Cys Cys Ser Lys Gln Glu Ala Gln 
        195                 200                 205             


Lys Arg Met Arg Val Lys Lys Leu Pro Met Ile Leu Ala Leu His Leu 
    210                 215                 220                 


Lys Arg Phe Lys Tyr Met Glu Gln Leu His Arg Tyr Thr Lys Leu Ser 
225                 230                 235                 240 


Tyr Arg Val Val Phe Pro Leu Glu Leu Arg Leu Phe Asn Thr Ser Ser 
                245                 250                 255     


Asp Ala Val Asn Leu Asp Arg Met Tyr Asp Leu Val Ala Val Val Val 
            260                 265                 270         


His Cys Gly Ser Gly Pro Asn Arg Gly His Tyr Ile Thr Ile Val Lys 
        275                 280                 285             


Ser His Gly Phe Trp Leu Leu Phe Asp Asp Asp Ile Val Glu Lys Ile 
    290                 295                 300                 


Asp Ala Gln Ala Ile Glu Glu Phe Tyr Gly Leu Thr Ser Asp Ile Ser 
305                 310                 315                 320 


Lys Asn Ser Glu Ser Gly Tyr Ile Leu Phe Tyr Gln Ser Arg 
                325                 330                 


<210> 179
<211> 363
<212> PRT
<213> Homo sapiens

<400> 179
Gly Lys Lys Lys Gly Ile Gln Gly His Tyr Asn Ser Cys Tyr Leu Asp 
1               5                   10                  15      


Ser Thr Leu Phe Cys Leu Phe Ala Phe Ser Ser Val Leu Asp Thr Val 
            20                  25                  30          


Leu Leu Arg Pro Lys Glu Lys Asn Asp Val Glu Tyr Tyr Ser Glu Thr 
        35                  40                  45              


Gln Glu Leu Leu Arg Thr Glu Ile Val Asn Pro Leu Arg Ile Tyr Gly 
    50                  55                  60                  


Tyr Val Cys Ala Thr Lys Ile Met Lys Leu Arg Lys Ile Leu Glu Lys 
65                  70                  75                  80  


Val Glu Ala Ala Ser Gly Phe Thr Ser Glu Glu Lys Asp Pro Glu Glu 
                85                  90                  95      


Phe Leu Asn Ile Leu Phe His His Ile Leu Arg Val Glu Pro Leu Leu 
            100                 105                 110         


Lys Ile Arg Ser Ala Gly Gln Lys Val Gln Asp Cys Tyr Phe Tyr Gln 
        115                 120                 125             


Ile Phe Met Glu Lys Asn Glu Lys Val Gly Val Pro Thr Ile Gln Gln 
    130                 135                 140                 


Leu Leu Glu Trp Ser Phe Ile Asn Ser Asn Leu Lys Phe Ala Glu Ala 
145                 150                 155                 160 


Pro Ser Cys Leu Ile Ile Gln Met Pro Arg Phe Gly Lys Asp Phe Lys 
                165                 170                 175     


Leu Phe Lys Lys Ile Phe Pro Ser Leu Glu Leu Asn Ile Thr Asp Leu 
            180                 185                 190         


Leu Glu Asp Thr Pro Arg Gln Cys Arg Ile Cys Gly Gly Leu Ala Met 
        195                 200                 205             


Tyr Glu Cys Arg Glu Cys Tyr Asp Asp Pro Asp Ile Ser Ala Gly Lys 
    210                 215                 220                 


Ile Lys Gln Phe Cys Lys Thr Cys Asn Thr Gln Val His Leu His Pro 
225                 230                 235                 240 


Lys Arg Leu Asn His Lys Tyr Asn Pro Val Ser Leu Pro Lys Asp Leu 
                245                 250                 255     


Pro Asp Trp Asp Trp Arg His Gly Cys Ile Pro Cys Gln Asn Met Glu 
            260                 265                 270         


Leu Phe Ala Val Leu Cys Ile Glu Thr Ser His Tyr Val Ala Phe Val 
        275                 280                 285             


Lys Tyr Gly Lys Asp Asp Ser Ala Trp Leu Phe Phe Asp Ser Met Ala 
    290                 295                 300                 


Asp Arg Asp Gly Gly Gln Asn Gly Phe Asn Ile Pro Gln Val Thr Pro 
305                 310                 315                 320 


Cys Pro Glu Val Gly Glu Tyr Leu Lys Met Ser Leu Glu Asp Leu His 
                325                 330                 335     


Ser Leu Asp Ser Arg Arg Ile Gln Gly Cys Ala Arg Arg Leu Leu Cys 
            340                 345                 350         


Asp Ala Tyr Met Cys Met Tyr Gln Ser Pro Thr 
        355                 360             


<210> 180
<211> 631
<212> PRT
<213> Homo sapiens

<400> 180
Ile Thr Val Lys Gly Leu Ser Asn Leu Gly Asn Thr Cys Phe Phe Asn 
1               5                   10                  15      


Ala Val Met Gln Asn Leu Ser Gln Thr Pro Val Leu Arg Glu Leu Leu 
            20                  25                  30          


Lys Glu Val Lys Met Ser Gly Thr Ile Val Lys Ile Glu Pro Pro Asp 
        35                  40                  45              


Leu Ala Leu Thr Glu Pro Leu Glu Ile Asn Leu Glu Pro Pro Gly Pro 
    50                  55                  60                  


Leu Thr Leu Ala Met Ser Gln Phe Leu Asn Glu Met Gln Glu Thr Lys 
65                  70                  75                  80  


Lys Gly Val Val Thr Pro Lys Glu Leu Phe Ser Gln Val Cys Lys Lys 
                85                  90                  95      


Ala Val Arg Phe Lys Gly Tyr Gln Gln Gln Asp Ser Gln Glu Leu Leu 
            100                 105                 110         


Arg Tyr Leu Leu Asp Gly Met Arg Ala Glu Glu His Gln Arg Val Ser 
        115                 120                 125             


Lys Gly Ile Leu Lys Ala Phe Gly Asn Ser Thr Glu Lys Leu Asp Glu 
    130                 135                 140                 


Glu Leu Lys Asn Lys Val Lys Asp Tyr Glu Lys Lys Lys Ser Met Pro 
145                 150                 155                 160 


Ser Phe Val Asp Arg Ile Phe Gly Gly Glu Leu Thr Ser Met Ile Met 
                165                 170                 175     


Cys Asp Gln Cys Arg Thr Val Ser Leu Val His Glu Ser Phe Leu Asp 
            180                 185                 190         


Leu Ser Leu Pro Val Leu Asp Asp Gln Ser Gly Lys Lys Ser Val Asn 
        195                 200                 205             


Asp Lys Asn Leu Lys Lys Thr Val Glu Asp Glu Asp Gln Asp Ser Glu 
    210                 215                 220                 


Glu Glu Lys Asp Asn Asp Ser Tyr Ile Lys Glu Arg Ser Asp Ile Pro 
225                 230                 235                 240 


Ser Gly Thr Ser Lys His Leu Gln Lys Lys Ala Lys Lys Gln Ala Lys 
                245                 250                 255     


Lys Gln Ala Lys Asn Gln Arg Arg Gln Gln Lys Ile Gln Gly Lys Val 
            260                 265                 270         


Leu His Leu Asn Asp Ile Cys Thr Ile Asp His Pro Glu Asp Ser Glu 
        275                 280                 285             


Tyr Glu Ala Glu Met Ser Leu Gln Gly Glu Val Asn Ile Lys Ser Asn 
    290                 295                 300                 


His Ile Ser Gln Glu Gly Val Met His Lys Glu Tyr Cys Val Asn Gln 
305                 310                 315                 320 


Lys Asp Leu Asn Gly Gln Ala Lys Met Ile Glu Ser Val Thr Asp Asn 
                325                 330                 335     


Gln Lys Ser Thr Glu Glu Val Asp Met Lys Asn Ile Asn Met Asp Asn 
            340                 345                 350         


Asp Leu Glu Val Leu Thr Ser Ser Pro Thr Arg Asn Leu Asn Gly Ala 
        355                 360                 365             


Tyr Leu Thr Glu Gly Ser Asn Gly Glu Val Asp Ile Ser Asn Gly Phe 
    370                 375                 380                 


Lys Asn Leu Asn Leu Asn Ala Ala Leu His Pro Asp Glu Ile Asn Ile 
385                 390                 395                 400 


Glu Ile Leu Asn Asp Ser His Thr Pro Gly Thr Lys Val Tyr Glu Val 
                405                 410                 415     


Val Asn Glu Asp Pro Glu Thr Ala Phe Cys Thr Leu Ala Asn Arg Glu 
            420                 425                 430         


Val Phe Asn Thr Asp Glu Cys Ser Ile Gln His Cys Leu Tyr Gln Phe 
        435                 440                 445             


Thr Arg Asn Glu Lys Leu Arg Asp Ala Asn Lys Leu Leu Cys Glu Val 
    450                 455                 460                 


Cys Thr Arg Arg Gln Cys Asn Gly Pro Lys Ala Asn Ile Lys Gly Glu 
465                 470                 475                 480 


Arg Lys His Val Tyr Thr Asn Ala Lys Lys Gln Met Leu Ile Ser Leu 
                485                 490                 495     


Ala Pro Pro Val Leu Thr Leu His Leu Lys Arg Phe Gln Gln Ala Gly 
            500                 505                 510         


Phe Asn Leu Arg Lys Val Asn Lys His Ile Lys Phe Pro Glu Ile Leu 
        515                 520                 525             


Asp Leu Ala Pro Phe Cys Thr Leu Lys Cys Lys Asn Val Ala Glu Glu 
    530                 535                 540                 


Asn Thr Arg Val Leu Tyr Ser Leu Tyr Gly Val Val Glu His Ser Gly 
545                 550                 555                 560 


Thr Met Arg Ser Gly His Tyr Thr Ala Tyr Ala Lys Ala Arg Thr Ala 
                565                 570                 575     


Asn Ser His Leu Ser Asn Leu Val Leu His Gly Asp Ile Pro Gln Asp 
            580                 585                 590         


Phe Glu Met Glu Ser Lys Gly Gln Trp Phe His Ile Ser Asp Thr His 
        595                 600                 605             


Val Gln Ala Val Pro Thr Thr Lys Val Leu Asn Ser Gln Ala Tyr Leu 
    610                 615                 620                 


Leu Phe Tyr Glu Arg Ile Leu 
625                 630     


<210> 181
<211> 291
<212> PRT
<213> Homo sapiens

<400> 181
Tyr Arg Tyr Lys Asp Ser Leu Lys Glu Asp Ile Gln Lys Ala Asp Leu 
1               5                   10                  15      


Val Ile Ser His Ala Gly Ala Gly Ser Cys Leu Glu Thr Leu Glu Lys 
            20                  25                  30          


Gly Lys Pro Leu Val Val Val Ile Asn Glu Lys Leu Met Asn Asn His 
        35                  40                  45              


Gln Leu Glu Leu Ala Lys Gln Leu His Lys Glu Gly His Leu Phe Tyr 
    50                  55                  60                  


Cys Thr Cys Arg Val Leu Thr Cys Pro Gly Gln Ala Lys Ser Ile Ala 
65                  70                  75                  80  


Ser Ala Pro Gly Lys Cys Gln Asp Ser Ala Ala Leu Thr Ser Thr Ala 
                85                  90                  95      


Phe Ser Gly Leu Asp Phe Gly Leu Leu Ser Gly Tyr Leu His Lys Gln 
            100                 105                 110         


Ala Leu Val Thr Ala Thr His Pro Thr Cys Thr Leu Leu Phe Pro Ser 
        115                 120                 125             


Cys His Ala Phe Phe Pro Leu Pro Leu Thr Pro Thr Leu Tyr Lys Met 
    130                 135                 140                 


His Lys Gly Trp Lys Asn Tyr Cys Ser Gln Lys Ser Leu Asn Glu Ala 
145                 150                 155                 160 


Ser Met Asp Glu Tyr Leu Gly Ser Leu Gly Leu Phe Arg Lys Leu Thr 
                165                 170                 175     


Ala Lys Asp Ala Ser Cys Leu Phe Arg Ala Ile Ser Glu Gln Leu Phe 
            180                 185                 190         


Cys Ser Gln Val His His Leu Glu Ile Arg Lys Ala Cys Val Ser Tyr 
        195                 200                 205             


Met Arg Glu Asn Gln Gln Thr Phe Glu Ser Tyr Val Glu Gly Ser Phe 
    210                 215                 220                 


Glu Lys Tyr Leu Glu Arg Leu Gly Asp Pro Lys Glu Ser Ala Gly Gln 
225                 230                 235                 240 


Leu Glu Ile Arg Ala Leu Ser Leu Ile Tyr Asn Arg Asp Phe Ile Leu 
                245                 250                 255     


Tyr Arg Phe Pro Gly Lys Pro Pro Thr Tyr Val Thr Asp Asn Gly Tyr 
            260                 265                 270         


Glu Asp Lys Ile Leu Leu Cys Tyr Ser Ser Ser Gly His Tyr Asp Ser 
        275                 280                 285             


Val Tyr Ser 
    290     


<210> 182
<211> 212
<212> PRT
<213> Homo sapiens

<400> 182
Gln Gly Leu Ser Ser Arg Thr Arg Val Arg Glu Leu Gln Gly Gln Ile 
1               5                   10                  15      


Ala Ala Ile Thr Gly Ile Ala Pro Gly Gly Gln Arg Ile Leu Val Gly 
            20                  25                  30          


Tyr Pro Pro Glu Cys Leu Asp Leu Ser Asn Gly Asp Thr Ile Leu Glu 
        35                  40                  45              


Asp Leu Pro Ile Gln Ser Gly Asp Met Leu Ile Ile Glu Glu Asp Gln 
    50                  55                  60                  


Thr Arg Pro Arg Ser Ser Pro Ala Phe Thr Lys Arg Gly Ala Ser Ser 
65                  70                  75                  80  


Tyr Val Arg Glu Thr Leu Pro Val Leu Thr Arg Thr Val Val Pro Ala 
                85                  90                  95      


Asp Asn Ser Cys Leu Phe Thr Ser Val Tyr Tyr Val Val Glu Gly Gly 
            100                 105                 110         


Val Leu Asn Pro Ala Cys Ala Pro Glu Met Arg Arg Leu Ile Ala Gln 
        115                 120                 125             


Ile Val Ala Ser Asp Pro Asp Phe Tyr Ser Glu Ala Ile Leu Gly Lys 
    130                 135                 140                 


Thr Asn Gln Glu Tyr Cys Asp Trp Ile Lys Arg Asp Asp Thr Trp Gly 
145                 150                 155                 160 


Gly Ala Ile Glu Ile Ser Ile Leu Ser Lys Phe Tyr Gln Cys Glu Ile 
                165                 170                 175     


Cys Val Val Asp Thr Gln Thr Val Arg Ile Asp Arg Phe Gly Glu Asp 
            180                 185                 190         


Ala Gly Tyr Thr Lys Arg Val Leu Leu Ile Tyr Asp Gly Ile His Tyr 
        195                 200                 205             


Asp Pro Leu Gln 
    210         


<210> 183
<211> 375
<212> PRT
<213> Homo sapiens

<400> 183
His Arg Glu Ala Ala Ala Val Pro Ala Ala Lys Met Pro Ala Phe Ser 
1               5                   10                  15      


Ser Cys Phe Glu Val Val Ser Gly Ala Ala Ala Pro Ala Ser Ala Ala 
            20                  25                  30          


Ala Gly Pro Pro Gly Ala Ser Cys Lys Pro Pro Leu Pro Pro His Tyr 
        35                  40                  45              


Thr Ser Thr Ala Gln Ile Thr Val Arg Ala Leu Gly Ala Asp Arg Leu 
    50                  55                  60                  


Leu Leu His Gly Pro Asp Pro Val Pro Gly Ala Ala Gly Ser Ala Ala 
65                  70                  75                  80  


Ala Pro Arg Gly Arg Cys Leu Leu Leu Ala Pro Ala Pro Ala Ala Pro 
                85                  90                  95      


Val Pro Pro Arg Arg Gly Ser Ser Ala Trp Leu Leu Glu Glu Leu Leu 
            100                 105                 110         


Arg Pro Asp Cys Pro Glu Pro Ala Gly Leu Asp Ala Thr Arg Glu Gly 
        115                 120                 125             


Pro Asp Arg Asn Phe Arg Leu Ser Glu His Arg Gln Ala Leu Ala Ala 
    130                 135                 140                 


Ala Lys His Arg Gly Pro Ala Ala Thr Pro Gly Ser Pro Asp Pro Gly 
145                 150                 155                 160 


Pro Gly Pro Trp Gly Glu Glu His Leu Ala Glu Arg Gly Pro Arg Gly 
                165                 170                 175     


Trp Glu Arg Gly Gly Asp Arg Cys Asp Ala Pro Gly Gly Asp Ala Ala 
            180                 185                 190         


Arg Arg Pro Asp Pro Glu Ala Glu Ala Pro Pro Ala Gly Ser Ile Glu 
        195                 200                 205             


Ala Ala Pro Ser Ser Ala Ala Glu Pro Val Ile Val Ser Arg Ser Asp 
    210                 215                 220                 


Pro Arg Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln 
225                 230                 235                 240 


Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro 
                245                 250                 255     


Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp 
            260                 265                 270         


Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala 
        275                 280                 285             


Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu 
    290                 295                 300                 


Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu 
305                 310                 315                 320 


Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr 
                325                 330                 335     


Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu 
            340                 345                 350         


Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser 
        355                 360                 365             


Asn Gly His Tyr Asp Ala Val 
    370                 375 


<210> 184
<211> 213
<212> PRT
<213> Homo sapiens

<400> 184
Gln Lys His Arg Glu Glu Leu Glu Gln Leu Lys Leu Thr Thr Lys Glu 
1               5                   10                  15      


Asn Lys Ile Asp Ser Val Ala Val Asn Ile Ser Asn Leu Val Leu Glu 
            20                  25                  30          


Asn Gln Pro Pro Arg Ile Ser Lys Ala Gln Lys Arg Arg Glu Lys Lys 
        35                  40                  45              


Ala Ala Leu Glu Lys Glu Arg Glu Glu Arg Ile Ala Glu Ala Glu Ile 
    50                  55                  60                  


Glu Asn Leu Thr Gly Ala Arg His Met Glu Ser Glu Lys Leu Ala Gln 
65                  70                  75                  80  


Ile Leu Ala Ala Arg Gln Leu Glu Ile Lys Gln Ile Pro Ser Asp Gly 
                85                  90                  95      


His Cys Met Tyr Lys Ala Ile Glu Asp Gln Leu Lys Glu Lys Asp Cys 
            100                 105                 110         


Ala Leu Thr Val Val Ala Leu Arg Ser Gln Thr Ala Glu Tyr Met Gln 
        115                 120                 125             


Ser His Val Glu Asp Phe Leu Pro Phe Leu Thr Asn Pro Asn Thr Gly 
    130                 135                 140                 


Asp Met Tyr Thr Pro Glu Glu Phe Gln Lys Tyr Cys Glu Asp Ile Val 
145                 150                 155                 160 


Asn Thr Ala Ala Trp Gly Gly Gln Leu Glu Leu Arg Ala Leu Ser His 
                165                 170                 175     


Ile Leu Gln Thr Pro Ile Glu Ile Ile Gln Ala Asp Ser Pro Pro Ile 
            180                 185                 190         


Ile Val Gly Glu Glu Tyr Ser Lys Lys Pro Leu Ile Leu Val Tyr Met 
        195                 200                 205             


Arg His Ala Tyr Gly 
    210             


<210> 185
<211> 204
<212> PRT
<213> Homo sapiens

<400> 185
Gln Glu Leu Glu Lys Phe Gln Asp Asp Ser Ser Ile Glu Ser Val Val 
1               5                   10                  15      


Glu Asp Leu Ala Lys Met Asn Leu Glu Asn Arg Pro Pro Arg Ser Ser 
            20                  25                  30          


Lys Ala His Arg Lys Arg Glu Arg Met Glu Ser Glu Glu Arg Glu Arg 
        35                  40                  45              


Gln Glu Ser Ile Phe Gln Ala Glu Met Ser Glu His Leu Ala Gly Phe 
    50                  55                  60                  


Lys Arg Glu Glu Glu Glu Lys Leu Ala Ala Ile Leu Gly Ala Arg Gly 
65                  70                  75                  80  


Leu Glu Met Lys Ala Ile Pro Ala Asp Gly His Cys Met Tyr Arg Ala 
                85                  90                  95      


Ile Gln Asp Gln Leu Val Phe Ser Val Ser Val Glu Met Leu Arg Cys 
            100                 105                 110         


Arg Thr Ala Ser Tyr Met Lys Lys His Val Asp Glu Phe Leu Pro Phe 
        115                 120                 125             


Phe Ser Asn Pro Glu Thr Ser Asp Ser Phe Gly Tyr Asp Asp Phe Met 
    130                 135                 140                 


Ile Tyr Cys Asp Asn Ile Val Arg Thr Thr Ala Trp Gly Gly Gln Leu 
145                 150                 155                 160 


Glu Leu Arg Ala Leu Ser His Val Leu Lys Thr Pro Ile Glu Val Ile 
                165                 170                 175     


Gln Ala Asp Ser Pro Thr Leu Ile Ile Gly Glu Glu Tyr Val Lys Lys 
            180                 185                 190         


Pro Ile Ile Leu Val Tyr Leu Arg Tyr Ala Tyr Ser 
        195                 200                 


<210> 186
<211> 311
<212> PRT
<213> Homo sapiens

<400> 186
Ser Asp Tyr Glu Gln Leu Arg Gln Val His Thr Ala Asn Leu Pro His 
1               5                   10                  15      


Val Phe Asn Glu Gly Arg Gly Pro Lys Gln Pro Glu Arg Glu Pro Gln 
            20                  25                  30          


Pro Gly His Lys Val Glu Arg Pro Cys Leu Gln Arg Gln Asp Asp Ile 
        35                  40                  45              


Ala Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ala 
    50                  55                  60                  


Ile Val Ser Leu Ala Arg Ser His Val Ala Ser Glu Cys Asn Asn Glu 
65                  70                  75                  80  


Gln Phe Pro Leu Glu Met Pro Ile Tyr Thr Phe Gln Leu Pro Asp Leu 
                85                  90                  95      


Ser Val Tyr Ser Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
            100                 105                 110         


Glu Gln Ala Thr Met Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
        115                 120                 125             


Trp Ser Thr Val Cys Thr Ser Cys Lys Arg Leu Leu Pro Leu Ala Thr 
    130                 135                 140                 


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
145                 150                 155                 160 


Gly Phe His Asp Arg Asp Leu Val Leu Arg Lys Ala Leu Tyr Thr Met 
                165                 170                 175     


Met Arg Thr Gly Ala Glu Arg Glu Ala Leu Lys Arg Arg Trp Arg Trp 
            180                 185                 190         


Gln Gln Thr Gln Gln Asn Lys Glu Glu Glu Trp Glu Arg Glu Trp Thr 
        195                 200                 205             


Glu Leu Leu Lys Leu Ala Ser Ser Glu Pro Arg Thr His Phe Ser Lys 
    210                 215                 220                 


Asn Gly Gly Thr Gly Gly Gly Val Asp Asn Ser Glu Asp Pro Val Tyr 
225                 230                 235                 240 


Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Ile Leu Arg 
                245                 250                 255     


Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly 
            260                 265                 270         


Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu 
        275                 280                 285             


Val Pro Pro Asn Arg Cys His Cys Ser Pro Leu Val Leu Ala Tyr Asp 
    290                 295                 300                 


Gln Ala His Phe Ser Ala Leu 
305                 310     


<210> 187
<211> 154
<212> PRT
<213> Homo sapiens

<400> 187
Met Glu Ala Ala Val Gly Val Pro Asp Gly Gly Asp Gln Gly Gly Ala 
1               5                   10                  15      


Gly Pro Arg Glu Asp Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            20                  25                  30          


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        35                  40                  45              


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    50                  55                  60                  


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
65                  70                  75                  80  


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                85                  90                  95      


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            100                 105                 110         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        115                 120                 125             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    130                 135                 140                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro 
145                 150                 


<210> 188
<211> 188
<212> PRT
<213> Homo sapiens

<400> 188
Met Ser Arg Lys Gln Ala Ala Lys Ser Arg Pro Gly Ser Gly Ser Arg 
1               5                   10                  15      


Lys Ala Glu Ala Glu Arg Lys Arg Asp Glu Arg Ala Ala Arg Arg Ala 
            20                  25                  30          


Leu Ala Lys Glu Arg Arg Asn Arg Pro Glu Ser Gly Gly Gly Gly Gly 
        35                  40                  45              


Cys Glu Glu Glu Phe Val Ser Phe Ala Asn Gln Leu Gln Ala Leu Gly 
    50                  55                  60                  


Leu Lys Leu Arg Glu Val Pro Gly Asp Gly Asn Cys Leu Phe Arg Ala 
65                  70                  75                  80  


Leu Gly Asp Gln Leu Glu Gly His Ser Arg Asn His Leu Lys His Arg 
                85                  90                  95      


Gln Glu Thr Val Asp Tyr Met Ile Lys Gln Arg Glu Asp Phe Glu Pro 
            100                 105                 110         


Phe Val Glu Asp Asp Ile Pro Phe Glu Lys His Val Ala Ser Leu Ala 
        115                 120                 125             


Lys Pro Gly Thr Phe Ala Gly Asn Asp Ala Ile Val Ala Phe Ala Arg 
    130                 135                 140                 


Asn His Gln Leu Asn Val Val Ile His Gln Leu Asn Ala Pro Leu Trp 
145                 150                 155                 160 


Gln Ile Arg Gly Thr Glu Lys Ser Ser Val Arg Glu Leu His Ile Ala 
                165                 170                 175     


Tyr Arg Tyr Gly Glu His Tyr Asp Ser Val Arg Arg 
            180                 185             


<210> 189
<211> 362
<212> PRT
<213> Homo sapiens

<400> 189
Met Thr Leu Asp Met Asp Ala Val Leu Ser Asp Phe Val Arg Ser Thr 
1               5                   10                  15      


Gly Ala Glu Pro Gly Leu Ala Arg Asp Leu Leu Glu Gly Lys Asn Trp 
            20                  25                  30          


Asp Val Asn Ala Ala Leu Ser Asp Phe Glu Gln Leu Arg Gln Val His 
        35                  40                  45              


Ala Gly Asn Leu Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
    50                  55                  60                  


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
65                  70                  75                  80  


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
                85                  90                  95      


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
            100                 105                 110         


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
        115                 120                 125             


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
    130                 135                 140                 


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
145                 150                 155                 160 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
                165                 170                 175     


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
            180                 185                 190         


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
        195                 200                 205             


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
    210                 215                 220                 


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
225                 230                 235                 240 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
                245                 250                 255     


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
            260                 265                 270         


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
        275                 280                 285             


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
    290                 295                 300                 


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
305                 310                 315                 320 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
                325                 330                 335     


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
            340                 345                 350         


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu 
        355                 360         


<210> 190
<211> 338
<212> PRT
<213> Homo sapiens

<400> 190
Met Thr Ile Leu Pro Lys Lys Lys Pro Pro Pro Pro Asp Ala Asp Pro 
1               5                   10                  15      


Ala Asn Glu Pro Pro Pro Pro Gly Pro Met Pro Pro Ala Pro Arg Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Val Gly Gly Gly Gly Thr Gly Val Gly Gly Gly 
        35                  40                  45              


Asp Arg Asp Arg Asp Ser Gly Val Val Gly Ala Arg Pro Arg Ala Ser 
    50                  55                  60                  


Pro Pro Pro Gln Gly Pro Leu Pro Gly Pro Pro Gly Ala Leu His Arg 
65                  70                  75                  80  


Trp Ala Leu Ala Val Pro Pro Gly Ala Val Ala Gly Pro Arg Pro Gln 
                85                  90                  95      


Gln Ala Ser Pro Pro Pro Cys Gly Gly Pro Gly Gly Pro Gly Gly Gly 
            100                 105                 110         


Pro Gly Asp Ala Leu Gly Ala Ala Ala Ala Gly Val Gly Ala Ala Gly 
        115                 120                 125             


Val Val Val Gly Val Gly Gly Ala Val Gly Val Gly Gly Cys Cys Ser 
    130                 135                 140                 


Gly Pro Gly His Ser Lys Arg Arg Arg Gln Ala Pro Gly Val Gly Ala 
145                 150                 155                 160 


Val Gly Gly Gly Ser Pro Glu Arg Glu Glu Val Gly Ala Gly Tyr Asn 
                165                 170                 175     


Ser Glu Asp Glu Tyr Glu Ala Ala Ala Ala Arg Ile Glu Ala Met Asp 
            180                 185                 190         


Pro Ala Thr Val Glu Gln Gln Glu His Trp Phe Glu Lys Ala Leu Arg 
        195                 200                 205             


Asp Lys Lys Gly Phe Ile Ile Lys Gln Met Lys Glu Asp Gly Ala Cys 
    210                 215                 220                 


Leu Phe Arg Ala Val Ala Asp Gln Val Tyr Gly Asp Gln Asp Met His 
225                 230                 235                 240 


Glu Val Val Arg Lys His Cys Met Asp Tyr Leu Met Lys Asn Ala Asp 
                245                 250                 255     


Tyr Phe Ser Asn Tyr Val Thr Glu Asp Phe Thr Thr Tyr Ile Asn Arg 
            260                 265                 270         


Lys Arg Lys Asn Asn Cys His Gly Asn His Ile Glu Met Gln Ala Met 
        275                 280                 285             


Ala Glu Met Tyr Asn Arg Pro Val Glu Val Tyr Gln Tyr Ser Thr Gly 
    290                 295                 300                 


Thr Ser Ala Val Glu Pro Ile Asn Thr Phe His Gly Ile His Gln Asn 
305                 310                 315                 320 


Glu Asp Glu Pro Ile Arg Val Ser Tyr His Arg Asn Ile His Tyr Asn 
                325                 330                 335     


Ser Val 
        


<210> 191
<211> 260
<212> PRT
<213> Homo sapiens

<400> 191
Met Ala Glu Gln Val Leu Pro Gln Ala Leu Tyr Leu Ser Asn Met Arg 
1               5                   10                  15      


Lys Ala Val Lys Ile Arg Glu Arg Thr Pro Glu Asp Ile Phe Lys Pro 
            20                  25                  30          


Thr Asn Gly Ile Ile His His Phe Lys Thr Met His Arg Tyr Thr Leu 
        35                  40                  45              


Glu Met Phe Arg Thr Cys Gln Phe Cys Pro Gln Phe Arg Glu Ile Ile 
    50                  55                  60                  


His Lys Ala Leu Ile Asp Arg Asn Ile Gln Ala Thr Leu Glu Ser Gln 
65                  70                  75                  80  


Lys Lys Leu Asn Trp Cys Arg Glu Val Arg Lys Leu Val Ala Leu Lys 
                85                  90                  95      


Thr Asn Gly Asp Gly Asn Cys Leu Met His Ala Thr Ser Gln Tyr Met 
            100                 105                 110         


Trp Gly Val Gln Asp Thr Asp Leu Val Leu Arg Lys Ala Leu Phe Ser 
        115                 120                 125             


Thr Leu Lys Glu Thr Asp Thr Arg Asn Phe Lys Phe Arg Trp Gln Leu 
    130                 135                 140                 


Glu Ser Leu Lys Ser Gln Glu Phe Val Glu Thr Gly Leu Cys Tyr Asp 
145                 150                 155                 160 


Thr Arg Asn Trp Asn Asp Glu Trp Asp Asn Leu Ile Lys Met Ala Ser 
                165                 170                 175     


Thr Asp Thr Pro Met Ala Arg Ser Gly Leu Gln Tyr Asn Ser Leu Glu 
            180                 185                 190         


Glu Ile His Ile Phe Val Leu Cys Asn Ile Leu Arg Arg Pro Ile Ile 
        195                 200                 205             


Val Ile Ser Asp Lys Met Leu Arg Ser Leu Glu Ser Gly Ser Asn Phe 
    210                 215                 220                 


Ala Pro Leu Lys Val Gly Gly Ile Tyr Leu Pro Leu His Trp Pro Ala 
225                 230                 235                 240 


Gln Glu Cys Tyr Arg Tyr Pro Ile Val Leu Gly Tyr Asp Ser His His 
                245                 250                 255     


Phe Val Pro Leu 
            260 


<210> 192
<211> 589
<212> PRT
<213> Homo sapiens

<400> 192
Met Ser Glu Arg Gly Ile Lys Trp Ala Cys Glu Tyr Cys Thr Tyr Glu 
1               5                   10                  15      


Asn Trp Pro Ser Ala Ile Lys Cys Thr Met Cys Arg Ala Gln Arg Pro 
            20                  25                  30          


Ser Gly Thr Ile Ile Thr Glu Asp Pro Phe Lys Ser Gly Ser Ser Asp 
        35                  40                  45              


Val Gly Arg Asp Trp Asp Pro Ser Ser Thr Glu Gly Gly Ser Ser Pro 
    50                  55                  60                  


Leu Ile Cys Pro Asp Ser Ser Ala Arg Pro Arg Val Lys Ser Ser Tyr 
65                  70                  75                  80  


Ser Met Glu Asn Ala Asn Lys Trp Ser Cys His Met Cys Thr Tyr Leu 
                85                  90                  95      


Asn Trp Pro Arg Ala Ile Arg Cys Thr Gln Cys Leu Ser Gln Arg Arg 
            100                 105                 110         


Thr Arg Ser Pro Thr Glu Ser Pro Gln Ser Ser Gly Ser Gly Ser Arg 
        115                 120                 125             


Pro Val Ala Phe Ser Val Asp Pro Cys Glu Glu Tyr Asn Asp Arg Asn 
    130                 135                 140                 


Lys Leu Asn Thr Arg Thr Gln His Trp Thr Cys Ser Val Cys Thr Tyr 
145                 150                 155                 160 


Glu Asn Trp Ala Lys Ala Lys Arg Cys Val Val Cys Asp His Pro Arg 
                165                 170                 175     


Pro Asn Asn Ile Glu Ala Ile Glu Leu Ala Glu Thr Glu Glu Ala Ser 
            180                 185                 190         


Ser Ile Ile Asn Glu Gln Asp Arg Ala Arg Trp Arg Gly Ser Cys Ser 
        195                 200                 205             


Ser Gly Asn Ser Gln Arg Arg Ser Pro Pro Ala Thr Lys Arg Asp Ser 
    210                 215                 220                 


Glu Val Lys Met Asp Phe Gln Arg Ile Glu Leu Ala Gly Ala Val Gly 
225                 230                 235                 240 


Ser Lys Glu Glu Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
                245                 250                 255     


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
            260                 265                 270         


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
        275                 280                 285             


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
    290                 295                 300                 


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
305                 310                 315                 320 


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
                325                 330                 335     


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
            340                 345                 350         


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
        355                 360                 365             


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
    370                 375                 380                 


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
385                 390                 395                 400 


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
                405                 410                 415     


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
            420                 425                 430         


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
        435                 440                 445             


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
    450                 455                 460                 


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
465                 470                 475                 480 


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
                485                 490                 495     


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
            500                 505                 510         


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
        515                 520                 525             


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
    530                 535                 540                 


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
545                 550                 555                 560 


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
                565                 570                 575     


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu 
            580                 585                 


<210> 193
<211> 298
<212> PRT
<213> Homo sapiens

<400> 193
Pro Ala Ser Gly Ser Val Ser Ile Glu Cys Thr Glu Cys Gly Gln Arg 
1               5                   10                  15      


His Glu Gln Gln Gln Leu Leu Gly Val Glu Glu Val Thr Asp Pro Asp 
            20                  25                  30          


Val Val Leu His Asn Leu Leu Arg Asn Ala Leu Leu Gly Val Thr Gly 
        35                  40                  45              


Ala Pro Lys Lys Asn Thr Glu Leu Val Lys Val Met Gly Leu Ser Asn 
    50                  55                  60                  


Tyr His Cys Lys Leu Leu Ser Pro Ile Leu Ala Arg Tyr Gly Met Asp 
65                  70                  75                  80  


Lys Gln Thr Gly Arg Ala Lys Leu Leu Arg Asp Met Asn Gln Gly Glu 
                85                  90                  95      


Leu Phe Asp Cys Ala Leu Leu Gly Asp Arg Ala Phe Leu Ile Glu Pro 
            100                 105                 110         


Glu His Val Asn Thr Val Gly Tyr Gly Lys Asp Arg Ser Gly Ser Leu 
        115                 120                 125             


Leu Tyr Leu His Asp Thr Leu Glu Asp Ile Lys Arg Ala Asn Lys Ser 
    130                 135                 140                 


Gln Glu Cys Leu Ile Pro Val His Val Asp Gly Asp Gly His Cys Leu 
145                 150                 155                 160 


Val His Ala Val Ser Arg Ala Leu Val Gly Arg Glu Leu Phe Trp His 
                165                 170                 175     


Ala Leu Arg Glu Asn Leu Lys Gln His Phe Gln Gln His Leu Ala Arg 
            180                 185                 190         


Tyr Gln Ala Leu Phe His Asp Phe Ile Asp Ala Ala Glu Trp Glu Asp 
        195                 200                 205             


Ile Ile Asn Glu Cys Asp Pro Leu Phe Val Pro Pro Glu Gly Val Pro 
    210                 215                 220                 


Leu Gly Leu Arg Asn Ile His Ile Phe Gly Leu Ala Asn Val Leu His 
225                 230                 235                 240 


Arg Pro Ile Ile Leu Leu Asp Ser Leu Ser Gly Met Arg Ser Ser Gly 
                245                 250                 255     


Asp Tyr Ser Ala Thr Phe Leu Pro Gly Leu Ile Pro Ala Glu Lys Cys 
            260                 265                 270         


Thr Gly Lys Asp Gly His Leu Asn Lys Pro Ile Cys Ile Ala Trp Ser 
        275                 280                 285             


Ser Ser Gly Arg Asn His Tyr Ile Pro Leu 
    290                 295             


<210> 194
<211> 227
<212> PRT
<213> Homo sapiens

<400> 194
Gln Arg Trp Leu Pro Leu Glu Ala Asn Pro Glu Val Thr Asn Gln Phe 
1               5                   10                  15      


Leu Lys Gln Leu Gly Leu His Pro Asn Trp Gln Phe Val Asp Val Tyr 
            20                  25                  30          


Gly Met Asp Pro Glu Leu Leu Ser Met Val Pro Arg Pro Val Cys Ala 
        35                  40                  45              


Val Leu Leu Leu Phe Pro Ile Thr Glu Lys Tyr Glu Val Phe Arg Thr 
    50                  55                  60                  


Glu Glu Glu Glu Lys Ile Lys Ser Gln Gly Gln Asp Val Thr Ser Ser 
65                  70                  75                  80  


Val Tyr Phe Met Lys Gln Thr Ile Ser Asn Ala Cys Gly Thr Ile Gly 
                85                  90                  95      


Leu Ile His Ala Ile Ala Asn Asn Lys Asp Lys Met His Phe Glu Ser 
            100                 105                 110         


Gly Ser Thr Leu Lys Lys Phe Leu Glu Glu Ser Val Ser Met Ser Pro 
        115                 120                 125             


Glu Glu Arg Ala Arg Tyr Leu Glu Asn Tyr Asp Ala Ile Arg Val Thr 
    130                 135                 140                 


His Glu Thr Ser Ala His Glu Gly Gln Thr Glu Ala Pro Ser Ile Asp 
145                 150                 155                 160 


Glu Lys Val Asp Leu His Phe Ile Ala Leu Val His Val Asp Gly His 
                165                 170                 175     


Leu Tyr Glu Leu Asp Gly Arg Lys Pro Phe Pro Ile Asn His Gly Glu 
            180                 185                 190         


Thr Ser Asp Glu Thr Leu Leu Glu Asp Ala Ile Glu Val Cys Lys Lys 
        195                 200                 205             


Phe Met Glu Arg Asp Pro Asp Glu Leu Arg Phe Asn Ala Ile Ala Leu 
    210                 215                 220                 


Ser Ala Ala 
225         


<210> 195
<211> 223
<212> PRT
<213> Homo sapiens

<400> 195
Gly Glu Trp Cys Leu Met Glu Ser Asp Pro Gly Val Phe Thr Glu Leu 
1               5                   10                  15      


Ile Lys Gly Phe Gly Cys Arg Gly Ala Gln Val Glu Glu Ile Trp Ser 
            20                  25                  30          


Leu Glu Pro Glu Asn Phe Glu Lys Leu Lys Pro Val His Gly Leu Ile 
        35                  40                  45              


Phe Leu Phe Lys Trp Gln Pro Gly Glu Glu Pro Ala Gly Ser Val Val 
    50                  55                  60                  


Gln Asp Ser Arg Leu Asp Thr Ile Phe Phe Ala Lys Gln Val Ile Asn 
65                  70                  75                  80  


Asn Ala Cys Ala Thr Gln Ala Ile Val Ser Val Leu Leu Asn Cys Thr 
                85                  90                  95      


His Gln Asp Val His Leu Gly Glu Thr Leu Ser Glu Phe Lys Glu Phe 
            100                 105                 110         


Ser Gln Ser Phe Asp Ala Ala Met Lys Gly Leu Ala Leu Ser Asn Ser 
        115                 120                 125             


Asp Val Ile Arg Gln Val His Asn Ser Phe Ala Arg Gln Gln Met Phe 
    130                 135                 140                 


Glu Phe Asp Thr Lys Thr Ser Ala Lys Glu Glu Asp Ala Phe His Phe 
145                 150                 155                 160 


Val Ser Tyr Val Pro Val Asn Gly Arg Leu Tyr Glu Leu Asp Gly Leu 
                165                 170                 175     


Arg Glu Gly Pro Ile Asp Leu Gly Ala Cys Asn Gln Asp Asp Trp Ile 
            180                 185                 190         


Ser Ala Val Arg Pro Val Ile Glu Lys Arg Ile Gln Lys Tyr Ser Glu 
        195                 200                 205             


Gly Glu Ile Arg Phe Asn Leu Met Ala Ile Val Ser Asp Arg Lys 
    210                 215                 220             


<210> 196
<211> 165
<212> PRT
<213> Homo sapiens

<400> 196
Glu Ser Ile Phe His Glu Lys Gln Glu Gly Ser Leu Cys Ala Gln His 
1               5                   10                  15      


Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu Leu 
            20                  25                  30          


Ser Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met Ala 
        35                  40                  45              


Glu Gly Gly Val Thr Ser Glu Asp Tyr Arg Thr Phe Leu Gln Gln Pro 
    50                  55                  60                  


Ser Gly Asn Met Asp Asp Ser Gly Phe Phe Ser Ile Gln Val Ile Ser 
65                  70                  75                  80  


Asn Ala Leu Lys Val Trp Gly Leu Glu Leu Ile Leu Phe Asn Ser Pro 
                85                  90                  95      


Glu Tyr Gln Arg Leu Arg Ile Asp Pro Ile Asn Glu Arg Ser Phe Ile 
            100                 105                 110         


Cys Asn Tyr Lys Glu His Trp Phe Thr Val Arg Lys Leu Gly Lys Gln 
        115                 120                 125             


Trp Phe Asn Leu Asn Ser Leu Leu Thr Gly Pro Glu Leu Ile Ser Asp 
    130                 135                 140                 


Thr Tyr Leu Ala Leu Phe Leu Ala Gln Leu Gln Gln Glu Gly Tyr Ser 
145                 150                 155                 160 


Ile Phe Val Val Lys 
                165 


<210> 197
<211> 163
<212> PRT
<213> Homo sapiens

<400> 197
Pro Thr Val Tyr His Glu Arg Gln Arg Leu Glu Leu Cys Ala Val His 
1               5                   10                  15      


Ala Leu Asn Asn Val Leu Gln Gln Gln Leu Phe Ser Gln Glu Ala Ala 
            20                  25                  30          


Asp Glu Ile Cys Lys Arg Leu Ala Pro Asp Ser Arg Leu Asn Pro His 
        35                  40                  45              


Arg Ser Leu Leu Gly Thr Gly Asn Tyr Asp Val Asn Val Ile Met Ala 
    50                  55                  60                  


Ala Leu Gln Gly Leu Gly Leu Ala Ala Val Trp Trp Asp Arg Arg Arg 
65                  70                  75                  80  


Pro Leu Ser Gln Leu Ala Leu Pro Gln Val Leu Gly Leu Ile Leu Asn 
                85                  90                  95      


Leu Pro Ser Pro Val Ser Leu Gly Leu Leu Ser Leu Pro Leu Arg Arg 
            100                 105                 110         


Arg His Trp Val Ala Leu Arg Gln Val Asp Gly Val Tyr Tyr Asn Leu 
        115                 120                 125             


Asp Ser Lys Leu Arg Ala Pro Glu Ala Leu Gly Asp Glu Asp Gly Val 
    130                 135                 140                 


Arg Ala Phe Leu Ala Ala Ala Leu Ala Gln Gly Leu Cys Glu Val Leu 
145                 150                 155                 160 


Leu Val Val 
            


<210> 198
<211> 170
<212> PRT
<213> Homo sapiens

<400> 198
Pro Gln Ala Ala Pro Pro Gln Ile Tyr His Glu Lys Gln Arg Arg Glu 
1               5                   10                  15      


Leu Cys Ala Leu His Ala Leu Asn Asn Val Phe Gln Asp Ser Asn Ala 
            20                  25                  30          


Phe Thr Arg Asp Thr Leu Gln Glu Ile Phe Gln Arg Leu Ser Pro Asn 
        35                  40                  45              


Thr Met Val Thr Pro His Lys Lys Ser Met Leu Gly Asn Gly Asn Tyr 
    50                  55                  60                  


Asp Val Asn Val Ile Met Ala Ala Leu Gln Thr Lys Gly Tyr Glu Ala 
65                  70                  75                  80  


Val Trp Trp Asp Lys Arg Arg Asp Val Gly Val Ile Ala Leu Thr Asn 
                85                  90                  95      


Val Met Gly Phe Ile Met Asn Leu Pro Ser Ser Leu Cys Trp Gly Pro 
            100                 105                 110         


Leu Lys Leu Pro Leu Lys Arg Gln His Trp Ile Cys Val Arg Glu Val 
        115                 120                 125             


Gly Gly Ala Tyr Tyr Asn Leu Asp Ser Lys Leu Lys Met Pro Glu Trp 
    130                 135                 140                 


Ile Gly Gly Glu Ser Glu Leu Arg Lys Phe Leu Lys His His Leu Arg 
145                 150                 155                 160 


Gly Lys Asn Cys Glu Leu Leu Leu Val Val 
                165                 170 


<210> 199
<211> 165
<212> PRT
<213> Homo sapiens

<400> 199
Asp Phe Ile Phe His Glu Lys Gln Glu Gly Phe Leu Cys Ala Gln His 
1               5                   10                  15      


Cys Leu Asn Asn Leu Leu Gln Gly Glu Tyr Phe Ser Pro Val Glu Leu 
            20                  25                  30          


Ala Ser Ile Ala His Gln Leu Asp Glu Glu Glu Arg Met Arg Met Ala 
        35                  40                  45              


Glu Gly Gly Val Thr Ser Glu Glu Tyr Leu Ala Phe Leu Gln Gln Pro 
    50                  55                  60                  


Ser Glu Asn Met Asp Asp Thr Gly Phe Phe Ser Ile Gln Val Ile Ser 
65                  70                  75                  80  


Asn Ala Leu Lys Phe Trp Gly Leu Glu Ile Ile His Phe Asn Asn Pro 
                85                  90                  95      


Glu Tyr Gln Lys Leu Gly Ile Asp Pro Ile Asn Glu Arg Ser Phe Ile 
            100                 105                 110         


Cys Asn Tyr Lys Gln His Trp Phe Thr Ile Arg Lys Phe Gly Lys His 
        115                 120                 125             


Trp Phe Asn Leu Asn Ser Leu Leu Ala Gly Pro Glu Leu Ile Ser Asp 
    130                 135                 140                 


Thr Cys Leu Ala Asn Phe Leu Ala Arg Leu Gln Gln Gln Ala Tyr Ser 
145                 150                 155                 160 


Val Phe Val Val Lys 
                165 


<210> 200
<211> 419
<212> PRT
<213> Homo sapiens

<400> 200
Cys Arg Trp Thr Gln Gly Phe Val Phe Ser Glu Ser Glu Gly Ser Ala 
1               5                   10                  15      


Leu Glu Gln Phe Glu Gly Gly Pro Cys Ala Val Ile Ala Pro Val Gln 
            20                  25                  30          


Ala Phe Leu Leu Lys Lys Leu Leu Phe Ser Ser Glu Lys Ser Ser Trp 
        35                  40                  45              


Arg Asp Cys Ser Glu Glu Glu Gln Lys Glu Leu Leu Cys His Thr Leu 
    50                  55                  60                  


Cys Asp Ile Leu Glu Ser Ala Cys Cys Asp His Ser Gly Ser Tyr Cys 
65                  70                  75                  80  


Leu Val Ser Trp Leu Arg Gly Lys Thr Thr Glu Glu Thr Ala Ser Ile 
                85                  90                  95      


Ser Gly Ser Pro Ala Glu Ser Ser Cys Gln Val Glu His Ser Ser Ala 
            100                 105                 110         


Leu Ala Val Glu Glu Leu Gly Phe Glu Arg Phe His Ala Leu Ile Gln 
        115                 120                 125             


Lys Arg Ser Phe Arg Ser Leu Pro Glu Leu Lys Asp Ala Val Leu Asp 
    130                 135                 140                 


Gln Tyr Ser Met Trp Gly Asn Lys Phe Gly Val Leu Leu Phe Leu Tyr 
145                 150                 155                 160 


Ser Val Leu Leu Thr Lys Gly Ile Glu Asn Ile Lys Asn Glu Ile Glu 
                165                 170                 175     


Asp Ala Ser Glu Pro Leu Ile Asp Pro Val Tyr Gly His Gly Ser Gln 
            180                 185                 190         


Ser Leu Ile Asn Leu Leu Leu Thr Gly His Ala Val Ser Asn Val Trp 
        195                 200                 205             


Asp Gly Asp Arg Glu Cys Ser Gly Met Lys Leu Leu Gly Ile His Glu 
    210                 215                 220                 


Gln Ala Ala Val Gly Phe Leu Thr Leu Met Glu Ala Leu Arg Tyr Cys 
225                 230                 235                 240 


Lys Val Gly Ser Tyr Leu Lys Ser Pro Lys Phe Pro Ile Trp Ile Val 
                245                 250                 255     


Gly Ser Glu Thr His Leu Thr Val Phe Phe Ala Lys Asp Met Ala Leu 
            260                 265                 270         


Val Ala Pro Glu Ala Pro Ser Glu Gln Ala Arg Arg Val Phe Gln Thr 
        275                 280                 285             


Tyr Asp Pro Glu Asp Asn Gly Phe Ile Pro Asp Ser Leu Leu Glu Asp 
    290                 295                 300                 


Val Met Lys Ala Leu Asp Leu Val Ser Asp Pro Glu Tyr Ile Asn Leu 
305                 310                 315                 320 


Met Lys Asn Lys Leu Asp Pro Glu Gly Leu Gly Ile Ile Leu Leu Gly 
                325                 330                 335     


Pro Phe Leu Gln Glu Phe Phe Pro Asp Gln Gly Ser Ser Gly Pro Glu 
            340                 345                 350         


Ser Phe Thr Val Tyr His Tyr Asn Gly Leu Lys Gln Ser Asn Tyr Asn 
        355                 360                 365             


Glu Lys Val Met Tyr Val Glu Gly Thr Ala Val Val Met Gly Phe Glu 
    370                 375                 380                 


Asp Pro Met Leu Gln Thr Asp Asp Thr Pro Ile Lys Arg Cys Leu Gln 
385                 390                 395                 400 


Thr Lys Trp Pro Tyr Ile Glu Leu Leu Trp Thr Thr Asp Arg Ser Pro 
                405                 410                 415     


Ser Leu Asn 
            


<210> 201
<211> 356
<212> PRT
<213> Homo sapiens

<400> 201
Tyr Cys Val Lys Trp Ile Pro Trp Lys Gly Glu Gln Thr Pro Ile Ile 
1               5                   10                  15      


Thr Gln Ser Thr Asn Gly Pro Cys Pro Leu Leu Ala Ile Met Asn Ile 
            20                  25                  30          


Leu Phe Leu Gln Trp Lys Val Lys Leu Pro Pro Gln Lys Glu Val Ile 
        35                  40                  45              


Thr Ser Asp Glu Leu Met Ala His Leu Gly Asn Cys Leu Leu Ser Ile 
    50                  55                  60                  


Lys Pro Gln Glu Lys Ser Glu Gly Leu Gln Leu Asn Phe Gln Gln Asn 
65                  70                  75                  80  


Val Asp Asp Ala Met Thr Val Leu Pro Lys Leu Ala Thr Gly Leu Asp 
                85                  90                  95      


Val Asn Val Arg Phe Thr Gly Val Ser Asp Phe Glu Tyr Thr Pro Glu 
            100                 105                 110         


Cys Ser Val Phe Asp Leu Leu Gly Ile Pro Leu Tyr His Gly Trp Leu 
        115                 120                 125             


Val Asp Pro Gln Ser Pro Glu Ala Val Arg Ala Val Gly Lys Leu Ser 
    130                 135                 140                 


Tyr Asn Gln Leu Val Glu Arg Ile Ile Thr Cys Lys His Ser Ser Asp 
145                 150                 155                 160 


Thr Asn Leu Val Thr Glu Gly Leu Ile Ala Glu Gln Phe Leu Glu Thr 
                165                 170                 175     


Thr Ala Ala Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ala Ala 
            180                 185                 190         


Ala Lys Glu Gly Glu Leu Ser Val Phe Phe Arg Asn Asn His Phe Ser 
        195                 200                 205             


Thr Met Thr Lys His Lys Ser His Leu Tyr Leu Leu Val Thr Asp Gln 
    210                 215                 220                 


Gly Phe Leu Gln Glu Glu Gln Val Val Trp Glu Ser Leu His Asn Val 
225                 230                 235                 240 


Asp Gly Asp Ser Cys Phe Cys Asp Ser Asp Phe His Leu Ser His Ser 
                245                 250                 255     


Leu Gly Lys Gly Pro Gly Ala Glu Gly Gly Ser Gly Ser Pro Glu Thr 
            260                 265                 270         


Gln Leu Gln Val Asp Gln Asp Tyr Leu Ile Ala Leu Ser Leu Gln Gln 
        275                 280                 285             


Gln Gln Pro Arg Gly Pro Leu Gly Leu Thr Asp Leu Glu Leu Ala Gln 
    290                 295                 300                 


Gln Leu Gln Gln Glu Glu Tyr Gln Gln Gln Gln Ala Ala Gln Pro Val 
305                 310                 315                 320 


Arg Met Arg Thr Arg Val Leu Ser Leu Gln Gly Arg Gly Ala Thr Ser 
                325                 330                 335     


Gly Arg Pro Ala Gly Glu Arg Arg Gln Arg Pro Lys His Glu Ser Asp 
            340                 345                 350         


Cys Ile Leu Leu 
        355     


<210> 202
<211> 379
<212> PRT
<213> Homo sapiens

<400> 202
Tyr His Ile Lys Trp Ile Gln Trp Lys Glu Glu Asn Thr Pro Ile Ile 
1               5                   10                  15      


Thr Gln Asn Glu Asn Gly Pro Cys Pro Leu Leu Ala Ile Leu Asn Val 
            20                  25                  30          


Leu Leu Leu Ala Trp Lys Val Lys Leu Pro Pro Met Met Glu Ile Ile 
        35                  40                  45              


Thr Ala Glu Gln Leu Met Glu Tyr Leu Gly Asp Tyr Met Leu Asp Ala 
    50                  55                  60                  


Lys Pro Lys Glu Ile Ser Glu Ile Gln Arg Leu Asn Tyr Glu Gln Asn 
65                  70                  75                  80  


Met Ser Asp Ala Met Ala Ile Leu His Lys Leu Gln Thr Gly Leu Asp 
                85                  90                  95      


Val Asn Val Arg Phe Thr Gly Val Arg Val Phe Glu Tyr Thr Pro Glu 
            100                 105                 110         


Cys Ile Val Phe Asp Leu Leu Asp Ile Pro Leu Tyr His Gly Trp Leu 
        115                 120                 125             


Val Asp Pro Gln Ile Asp Asp Ile Val Lys Ala Val Gly Asn Cys Ser 
    130                 135                 140                 


Tyr Asn Gln Leu Val Glu Lys Ile Ile Ser Cys Lys Gln Ser Asp Asn 
145                 150                 155                 160 


Ser Glu Leu Val Ser Glu Gly Phe Val Ala Glu Gln Phe Leu Asn Asn 
                165                 170                 175     


Thr Ala Thr Gln Leu Thr Tyr His Gly Leu Cys Glu Leu Thr Ser Thr 
            180                 185                 190         


Val Gln Glu Gly Glu Leu Cys Val Phe Phe Arg Asn Asn His Phe Ser 
        195                 200                 205             


Thr Met Thr Lys Tyr Lys Gly Gln Leu Tyr Leu Leu Val Thr Asp Gln 
    210                 215                 220                 


Gly Phe Leu Thr Glu Glu Lys Val Val Trp Glu Ser Leu His Asn Val 
225                 230                 235                 240 


Asp Gly Asp Gly Asn Phe Cys Asp Ser Glu Phe His Leu Arg Pro Pro 
                245                 250                 255     


Ser Asp Pro Glu Thr Val Tyr Lys Gly Gln Gln Asp Gln Ile Asp Gln 
            260                 265                 270         


Asp Tyr Leu Met Ala Leu Ser Leu Gln Gln Glu Gln Gln Ser Gln Glu 
        275                 280                 285             


Ile Asn Trp Glu Gln Ile Pro Glu Gly Ile Ser Asp Leu Glu Leu Ala 
    290                 295                 300                 


Lys Lys Leu Gln Glu Glu Glu Asp Arg Arg Ala Ser Gln Tyr Tyr Gln 
305                 310                 315                 320 


Glu Gln Glu Gln Ala Ala Ala Ala Ala Ala Ala Ala Ser Thr Gln Ala 
                325                 330                 335     


Gln Gln Gly Gln Pro Ala Gln Ala Ser Pro Ser Ser Gly Arg Gln Ser 
            340                 345                 350         


Gly Asn Ser Glu Arg Lys Arg Lys Glu Pro Arg Glu Lys Asp Lys Glu 
        355                 360                 365             


Lys Glu Lys Glu Lys Asn Ser Cys Val Ile Leu 
    370                 375                 


<210> 203
<211> 334
<212> PRT
<213> Homo sapiens

<400> 203
Phe Cys Cys Phe Asn Glu Glu Trp Lys Leu Gln Ser Phe Ser Phe Ser 
1               5                   10                  15      


Asn Thr Ala Ser Leu Lys Tyr Gly Ile Val Gln Asn Lys Gly Gly Pro 
            20                  25                  30          


Cys Gly Val Leu Ala Ala Val Gln Gly Cys Val Leu Gln Lys Leu Leu 
        35                  40                  45              


Phe Glu Gly Asp Ser Lys Ala Asp Cys Ala Gln Gly Leu Gln Pro Ser 
    50                  55                  60                  


Asp Ala His Arg Thr Arg Cys Leu Val Leu Ala Leu Ala Asp Ile Val 
65                  70                  75                  80  


Trp Arg Ala Gly Gly Arg Glu Arg Ala Val Val Ala Leu Ala Ser Arg 
                85                  90                  95      


Thr Gln Gln Phe Ser Pro Thr Gly Lys Tyr Lys Ala Asp Gly Val Leu 
            100                 105                 110         


Glu Thr Leu Thr Leu His Ser Leu Thr Cys Tyr Glu Asp Leu Val Thr 
        115                 120                 125             


Phe Leu Gln Gln Ser Ile His Gln Phe Glu Val Gly Pro Tyr Gly Cys 
    130                 135                 140                 


Ile Leu Leu Thr Leu Ser Ala Ile Leu Ser Arg Ser Thr Glu Leu Ile 
145                 150                 155                 160 


Arg Gln Asp Phe Asp Val Pro Thr Ser His Leu Ile Gly Ala His Gly 
                165                 170                 175     


Tyr Cys Thr Gln Glu Leu Val Asn Leu Leu Leu Thr Gly Lys Ala Val 
            180                 185                 190         


Ser Asn Val Phe Asn Asp Val Val Glu Leu Asp Ser Gly Asp Gly Asn 
        195                 200                 205             


Ile Thr Leu Leu Arg Gly Ile Ala Ala Arg Ser Asp Ile Gly Phe Leu 
    210                 215                 220                 


Ser Leu Phe Glu His Tyr Asn Met Cys Gln Val Gly Cys Phe Leu Lys 
225                 230                 235                 240 


Thr Pro Arg Phe Pro Ile Trp Val Val Cys Ser Glu Ser His Phe Ser 
                245                 250                 255     


Ile Leu Phe Ser Leu Gln Pro Gly Leu Leu Arg Asp Trp Arg Thr Glu 
            260                 265                 270         


Arg Leu Phe Asp Leu Tyr Tyr Tyr Asp Gly Leu Ala Asn Gln Gln Glu 
        275                 280                 285             


Gln Ile Arg Leu Thr Ile Asp Thr Thr Gln Thr Ile Ser Glu Asp Thr 
    290                 295                 300                 


Asp Asn Asp Leu Val Pro Pro Leu Glu Leu Cys Ile Arg Thr Lys Trp 
305                 310                 315                 320 


Lys Gly Ala Ser Val Asn Trp Asn Gly Ser Asp Pro Ile Leu 
                325                 330                 


<210> 204
<211> 167
<212> PRT
<213> Homo sapiens

<400> 204
Val Val Pro Gly Arg Leu Cys Pro Gln Phe Leu Gln Leu Ala Ser Ala 
1               5                   10                  15      


Asn Thr Ala Arg Gly Val Glu Thr Cys Gly Ile Leu Cys Gly Lys Leu 
            20                  25                  30          


Met Arg Asn Glu Phe Thr Ile Thr His Val Leu Ile Pro Lys Gln Ser 
        35                  40                  45              


Ala Gly Ser Asp Tyr Cys Asn Thr Glu Asn Glu Glu Glu Leu Phe Leu 
    50                  55                  60                  


Ile Gln Asp Gln Gln Gly Leu Ile Thr Leu Gly Trp Ile His Thr His 
65                  70                  75                  80  


Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His Cys 
                85                  90                  95      


Ser Tyr Gln Met Met Leu Pro Glu Ser Val Ala Ile Val Cys Ser Pro 
            100                 105                 110         


Lys Phe Gln Glu Thr Gly Phe Phe Lys Leu Thr Asp His Gly Leu Glu 
        115                 120                 125             


Glu Ile Ser Ser Cys Arg Gln Lys Gly Phe His Pro His Ser Lys Asp 
    130                 135                 140                 


Pro Pro Leu Phe Cys Ser Cys Ser His Val Thr Val Val Asp Arg Ala 
145                 150                 155                 160 


Val Thr Ile Thr Asp Leu Arg 
                165         


<210> 205
<211> 200
<212> PRT
<213> Homo sapiens

<400> 205
Val Ala Val Ser Ser Asn Val Leu Phe Leu Leu Asp Phe His Ser His 
1               5                   10                  15      


Leu Thr Arg Ser Glu Val Val Gly Tyr Leu Gly Gly Arg Trp Asp Val 
            20                  25                  30          


Asn Ser Gln Met Leu Thr Val Leu Arg Ala Phe Pro Cys Arg Ser Arg 
        35                  40                  45              


Leu Gly Asp Ala Glu Thr Ala Ala Ala Ile Glu Glu Glu Ile Tyr Gln 
    50                  55                  60                  


Ser Leu Phe Leu Arg Gly Leu Ser Leu Val Gly Trp Tyr His Ser His 
65                  70                  75                  80  


Pro His Ser Pro Ala Leu Pro Ser Leu Gln Asp Ile Asp Ala Gln Met 
                85                  90                  95      


Asp Tyr Gln Leu Arg Leu Gln Gly Ser Ser Asn Gly Phe Gln Pro Cys 
            100                 105                 110         


Leu Ala Leu Leu Cys Ser Pro Tyr Tyr Ser Gly Asn Pro Gly Pro Glu 
        115                 120                 125             


Ser Lys Ile Ser Pro Phe Trp Val Met Pro Pro Pro Glu Met Leu Leu 
    130                 135                 140                 


Val Glu Phe Tyr Lys Gly Ser Pro Asp Leu Val Arg Leu Gln Glu Pro 
145                 150                 155                 160 


Trp Ser Gln Glu His Thr Tyr Leu Asp Lys Leu Lys Ile Ser Leu Ala 
                165                 170                 175     


Ser Arg Thr Pro Lys Asp Gln Ser Leu Cys His Val Leu Glu Gln Val 
            180                 185                 190         


Cys Gly Val Leu Lys Gln Gly Ser 
        195                 200 


<210> 206
<211> 201
<212> PRT
<213> Homo sapiens

<400> 206
Ala Leu Ala Tyr Val Lys Met Cys Leu His Ala Ala Arg Tyr Pro His 
1               5                   10                  15      


Ala Ala Val Asn Gly Leu Phe Leu Ala Pro Ala Pro Arg Ser Gly Glu 
            20                  25                  30          


Cys Leu Cys Leu Thr Asp Cys Val Pro Leu Phe His Ser His Leu Ala 
        35                  40                  45              


Leu Ser Val Met Leu Glu Val Ala Leu Asn Gln Val Asp Val Trp Gly 
    50                  55                  60                  


Ala Gln Ala Gly Leu Val Val Ala Gly Tyr Tyr His Ala Asn Ala Ala 
65                  70                  75                  80  


Val Asn Asp Gln Ser Pro Gly Pro Leu Ala Leu Lys Ile Ala Gly Arg 
                85                  90                  95      


Ile Ala Glu Phe Phe Pro Asp Ala Val Leu Ile Met Leu Asp Asn Gln 
            100                 105                 110         


Lys Leu Val Pro Gln Pro Arg Val Pro Pro Val Ile Val Leu Glu Asn 
        115                 120                 125             


Gln Gly Leu Arg Trp Val Pro Lys Asp Lys Asn Leu Val Met Trp Arg 
    130                 135                 140                 


Asp Trp Glu Glu Ser Arg Gln Met Val Gly Ala Leu Leu Glu Asp Arg 
145                 150                 155                 160 


Ala His Gln His Leu Val Asp Phe Asp Cys His Leu Asp Asp Ile Arg 
                165                 170                 175     


Gln Asp Trp Thr Asn Gln Arg Leu Asn Thr Gln Ile Thr Gln Trp Val 
            180                 185                 190         


Gly Pro Thr Asn Gly Asn Gly Asn Ala 
        195                 200     


<210> 207
<211> 281
<212> PRT
<213> Homo sapiens

<400> 207
Gln Val Tyr Ile Ser Ser Leu Ala Leu Leu Lys Met Leu Lys His Gly 
1               5                   10                  15      


Arg Ala Gly Val Pro Met Glu Val Met Gly Leu Met Leu Gly Glu Phe 
            20                  25                  30          


Val Asp Asp Tyr Thr Val Arg Val Ile Asp Val Phe Ala Met Pro Gln 
        35                  40                  45              


Ser Gly Thr Gly Val Ser Val Glu Ala Val Asp Pro Val Phe Gln Ala 
    50                  55                  60                  


Lys Met Leu Asp Met Leu Lys Gln Thr Gly Arg Pro Glu Met Val Val 
65                  70                  75                  80  


Gly Trp Tyr His Ser His Pro Gly Phe Gly Cys Trp Leu Ser Gly Val 
                85                  90                  95      


Asp Ile Asn Thr Gln Gln Ser Phe Glu Ala Leu Ser Glu Arg Ala Val 
            100                 105                 110         


Ala Val Val Val Asp Pro Ile Gln Ser Val Lys Gly Lys Val Val Ile 
        115                 120                 125             


Asp Ala Phe Arg Leu Ile Asn Ala Asn Met Met Val Leu Gly His Glu 
    130                 135                 140                 


Pro Arg Gln Thr Thr Ser Asn Leu Gly His Leu Asn Lys Pro Ser Ile 
145                 150                 155                 160 


Gln Ala Leu Ile His Gly Leu Asn Arg His Tyr Tyr Ser Ile Thr Ile 
                165                 170                 175     


Asn Tyr Arg Lys Asn Glu Leu Glu Gln Lys Met Leu Leu Asn Leu His 
            180                 185                 190         


Lys Lys Ser Trp Met Glu Gly Leu Thr Leu Gln Asp Tyr Ser Glu His 
        195                 200                 205             


Cys Lys His Asn Glu Ser Val Val Lys Glu Met Leu Glu Leu Ala Lys 
    210                 215                 220                 


Asn Tyr Asn Lys Ala Val Glu Glu Glu Asp Lys Met Thr Pro Glu Gln 
225                 230                 235                 240 


Leu Ala Ile Lys Asn Val Gly Lys Gln Asp Pro Lys Arg His Leu Glu 
                245                 250                 255     


Glu His Val Asp Val Leu Met Thr Ser Asn Ile Val Gln Cys Leu Ala 
            260                 265                 270         


Ala Met Leu Asp Thr Val Val Phe Lys 
        275                 280     


<210> 208
<211> 253
<212> PRT
<213> Homo sapiens

<400> 208
Gln Val Lys Val Ala Ser Glu Ala Leu Leu Ile Met Asp Leu His Ala 
1               5                   10                  15      


His Val Ser Met Ala Glu Val Ile Gly Leu Leu Gly Gly Arg Tyr Ser 
            20                  25                  30          


Glu Val Asp Lys Val Val Glu Val Cys Ala Ala Glu Pro Cys Asn Ser 
        35                  40                  45              


Leu Ser Thr Gly Leu Gln Cys Glu Met Asp Pro Val Ser Gln Thr Gln 
    50                  55                  60                  


Ala Ser Glu Thr Leu Ala Val Arg Gly Phe Ser Val Ile Gly Trp Tyr 
65                  70                  75                  80  


His Ser His Pro Ala Phe Asp Pro Asn Pro Ser Leu Arg Asp Ile Asp 
                85                  90                  95      


Thr Gln Ala Lys Tyr Gln Ser Tyr Phe Ser Arg Gly Gly Ala Lys Phe 
            100                 105                 110         


Ile Gly Met Ile Val Ser Pro Tyr Asn Arg Asn Asn Pro Leu Pro Tyr 
        115                 120                 125             


Ser Gln Ile Thr Cys Leu Val Ile Ser Glu Glu Ile Ser Pro Asp Gly 
    130                 135                 140                 


Ser Tyr Arg Leu Pro Tyr Lys Phe Glu Val Gln Gln Met Leu Glu Glu 
145                 150                 155                 160 


Pro Gln Trp Gly Leu Val Phe Glu Lys Thr Arg Trp Ile Ile Glu Lys 
                165                 170                 175     


Tyr Arg Leu Ser His Ser Ser Val Pro Met Asp Lys Ile Phe Arg Arg 
            180                 185                 190         


Asp Ser Asp Leu Thr Cys Leu Gln Lys Leu Leu Glu Cys Met Arg Lys 
        195                 200                 205             


Thr Leu Ser Lys Val Thr Asn Cys Phe Met Ala Glu Glu Phe Leu Thr 
    210                 215                 220                 


Glu Ile Glu Asn Leu Phe Leu Ser Asn Tyr Lys Ser Asn Gln Glu Asn 
225                 230                 235                 240 


Gly Val Thr Glu Glu Asn Cys Thr Lys Glu Leu Leu Met 
                245                 250             


<210> 209
<211> 404
<212> PRT
<213> Homo sapiens

<400> 209
Ala Val Cys Phe His Ser Ala Asn Ser Asn Ala Asp His Glu Gly Phe 
1               5                   10                  15      


Leu Leu Gly Glu Val Arg Gln Glu Glu Thr Phe Ser Ile Ser Asp Ser 
            20                  25                  30          


Gln Ile Ser Asn Thr Glu Phe Leu Gln Val Ile Glu Ile His Asn His 
        35                  40                  45              


Gln Pro Cys Ser Lys Leu Phe Ser Phe Tyr Asp Tyr Ala Ser Lys Val 
    50                  55                  60                  


Asn Glu Glu Ser Leu Asp Arg Ile Leu Lys Asp Arg Arg Lys Lys Val 
65                  70                  75                  80  


Ile Gly Trp Tyr Arg Phe Arg Arg Asn Thr Gln Gln Gln Met Ser Tyr 
                85                  90                  95      


Arg Glu Gln Val Leu His Lys Gln Leu Thr Arg Ile Leu Gly Val Pro 
            100                 105                 110         


Asp Leu Val Phe Leu Leu Phe Ser Phe Ile Ser Thr Ala Asn Asn Ser 
        115                 120                 125             


Thr His Ala Leu Glu Tyr Val Leu Phe Arg Pro Asn Arg Arg Tyr Asn 
    130                 135                 140                 


Gln Arg Ile Ser Leu Ala Ile Pro Asn Leu Gly Asn Thr Ser Gln Gln 
145                 150                 155                 160 


Glu Tyr Lys Val Ser Ser Val Pro Asn Thr Ser Gln Ser Tyr Ala Lys 
                165                 170                 175     


Val Ile Lys Glu His Gly Thr Asp Phe Phe Asp Lys Asp Gly Val Met 
            180                 185                 190         


Lys Asp Ile Arg Ala Ile Tyr Gln Val Tyr Asn Ala Leu Gln Glu Lys 
        195                 200                 205             


Val Gln Ala Val Cys Ala Asp Val Glu Lys Ser Glu Arg Val Val Glu 
    210                 215                 220                 


Ser Cys Gln Ala Glu Val Asn Lys Leu Arg Arg Gln Ile Thr Gln Arg 
225                 230                 235                 240 


Lys Asn Glu Lys Glu Gln Glu Arg Arg Leu Gln Gln Ala Val Leu Ser 
                245                 250                 255     


Arg Gln Met Pro Ser Glu Ser Leu Asp Pro Ala Phe Ser Pro Arg Met 
            260                 265                 270         


Pro Ser Ser Gly Phe Ala Ala Glu Gly Arg Ser Thr Leu Gly Asp Ala 
        275                 280                 285             


Glu Ala Ser Asp Pro Pro Pro Pro Tyr Ser Asp Phe His Pro Asn Asn 
    290                 295                 300                 


Gln Glu Ser Thr Leu Ser His Ser Arg Met Glu Arg Ser Val Phe Met 
305                 310                 315                 320 


Pro Arg Pro Gln Ala Val Gly Ser Ser Asn Tyr Ala Ser Thr Ser Ala 
                325                 330                 335     


Gly Leu Lys Tyr Pro Gly Ser Gly Ala Asp Leu Pro Pro Pro Gln Arg 
            340                 345                 350         


Ala Ala Gly Asp Ser Gly Glu Asp Ser Asp Asp Ser Asp Tyr Glu Asn 
        355                 360                 365             


Leu Ile Asp Pro Thr Glu Pro Ser Asn Ser Glu Tyr Ser His Ser Lys 
    370                 375                 380                 


Asp Ser Arg Pro Met Ala His Pro Asp Glu Asp Pro Arg Asn Thr Gln 
385                 390                 395                 400 


Thr Ser Gln Ile 
                


<210> 210
<211> 526
<212> PRT
<213> Homo sapiens

<400> 210
Phe Asn Pro Arg Thr Gly Gln Leu Phe Leu Lys Ile Ile His Thr Ser 
1               5                   10                  15      


Val Trp Ala Gly Gln Lys Arg Leu Gly Gln Leu Ala Lys Trp Lys Thr 
            20                  25                  30          


Ala Glu Glu Val Ala Ala Leu Ile Arg Ser Leu Pro Val Glu Glu Gln 
        35                  40                  45              


Pro Lys Gln Ile Ile Val Thr Arg Lys Gly Met Leu Asp Pro Leu Glu 
    50                  55                  60                  


Val His Leu Leu Asp Phe Pro Asn Ile Val Ile Lys Gly Ser Glu Leu 
65                  70                  75                  80  


Gln Leu Pro Phe Gln Ala Cys Leu Lys Val Glu Lys Phe Gly Asp Leu 
                85                  90                  95      


Ile Leu Lys Ala Thr Glu Pro Gln Met Val Leu Phe Asn Leu Tyr Asp 
            100                 105                 110         


Asp Trp Leu Lys Thr Ile Ser Ser Tyr Thr Ala Phe Ser Arg Leu Ile 
        115                 120                 125             


Leu Ile Leu Arg Ala Leu His Val Asn Asn Asp Arg Ala Lys Val Ile 
    130                 135                 140                 


Leu Lys Pro Asp Lys Thr Thr Ile Thr Glu Pro His His Ile Trp Pro 
145                 150                 155                 160 


Thr Leu Thr Asp Glu Glu Trp Ile Lys Val Glu Val Gln Leu Lys Asp 
                165                 170                 175     


Leu Ile Leu Ala Asp Tyr Gly Lys Lys Asn Asn Val Asn Val Ala Ser 
            180                 185                 190         


Leu Thr Gln Ser Glu Ile Arg Asp Ile Ile Leu Gly Met Glu Ile Ser 
        195                 200                 205             


Ala Pro Ser Gln Gln Arg Gln Gln Ile Ala Glu Ile Glu Lys Gln Thr 
    210                 215                 220                 


Lys Glu Gln Ser Gln Leu Thr Ala Thr Gln Thr Arg Thr Val Asn Lys 
225                 230                 235                 240 


His Gly Asp Glu Ile Ile Thr Ser Thr Thr Ser Asn Tyr Glu Thr Gln 
                245                 250                 255     


Thr Phe Ser Ser Lys Thr Glu Trp Arg Val Arg Ala Ile Ser Ala Ala 
            260                 265                 270         


Asn Leu His Leu Arg Thr Asn His Ile Tyr Val Ser Ser Asp Asp Ile 
        275                 280                 285             


Lys Glu Thr Gly Tyr Thr Tyr Ile Leu Pro Lys Asn Val Leu Lys Lys 
    290                 295                 300                 


Phe Ile Cys Ile Ser Asp Leu Arg Ala Gln Ile Ala Gly Tyr Leu Tyr 
305                 310                 315                 320 


Gly Val Ser Pro Pro Asp Asn Pro Gln Val Lys Glu Ile Arg Cys Ile 
                325                 330                 335     


Val Met Val Pro Gln Trp Gly Thr His Gln Thr Val His Leu Pro Gly 
            340                 345                 350         


Gln Leu Pro Gln His Glu Tyr Leu Lys Glu Met Glu Pro Leu Gly Trp 
        355                 360                 365             


Ile His Thr Gln Pro Asn Glu Ser Pro Gln Leu Ser Pro Gln Asp Val 
    370                 375                 380                 


Thr Thr His Ala Lys Ile Met Ala Asp Asn Pro Ser Trp Asp Gly Glu 
385                 390                 395                 400 


Lys Thr Ile Ile Ile Thr Cys Ser Phe Thr Pro Gly Ser Cys Thr Leu 
                405                 410                 415     


Thr Ala Tyr Lys Leu Thr Pro Ser Gly Tyr Glu Trp Gly Arg Gln Asn 
            420                 425                 430         


Thr Asp Lys Gly Asn Asn Pro Lys Gly Tyr Leu Pro Ser His Tyr Glu 
        435                 440                 445             


Arg Val Gln Met Leu Leu Ser Asp Arg Phe Leu Gly Phe Phe Met Val 
    450                 455                 460                 


Pro Ala Gln Ser Ser Trp Asn Tyr Asn Phe Met Gly Val Arg His Asp 
465                 470                 475                 480 


Pro Asn Met Lys Tyr Glu Leu Gln Leu Ala Asn Pro Lys Glu Phe Tyr 
                485                 490                 495     


His Glu Val His Arg Pro Ser His Phe Leu Asn Phe Ala Leu Leu Gln 
            500                 505                 510         


Glu Gly Glu Val Tyr Ser Ala Asp Arg Glu Asp Leu Tyr Ala 
        515                 520                 525     


<210> 211
<211> 400
<212> PRT
<213> Homo sapiens

<400> 211
Gln Pro Ser Ala Ile Thr Leu Asn Arg Gln Lys Tyr Arg His Val Asp 
1               5                   10                  15      


Asn Ile Met Phe Glu Asn His Thr Val Ala Asp Arg Phe Leu Asp Phe 
            20                  25                  30          


Trp Arg Lys Thr Gly Asn Gln His Phe Gly Tyr Leu Tyr Gly Arg Tyr 
        35                  40                  45              


Thr Glu His Lys Asp Ile Pro Leu Gly Ile Arg Ala Glu Val Ala Ala 
    50                  55                  60                  


Ile Tyr Glu Pro Pro Gln Ile Gly Thr Gln Asn Ser Leu Glu Leu Leu 
65                  70                  75                  80  


Glu Asp Pro Lys Ala Glu Val Val Asp Glu Ile Ala Ala Lys Leu Gly 
                85                  90                  95      


Leu Arg Lys Val Gly Trp Ile Phe Thr Asp Leu Val Ser Glu Asp Thr 
            100                 105                 110         


Arg Lys Gly Thr Val Arg Tyr Ser Arg Asn Lys Asp Thr Tyr Phe Leu 
        115                 120                 125             


Ser Ser Glu Glu Cys Ile Thr Ala Gly Asp Phe Gln Asn Lys His Pro 
    130                 135                 140                 


Asn Met Cys Arg Leu Ser Pro Asp Gly His Phe Gly Ser Lys Phe Val 
145                 150                 155                 160 


Thr Ala Val Ala Thr Gly Gly Pro Asp Asn Gln Val His Phe Glu Gly 
                165                 170                 175     


Tyr Gln Val Ser Asn Gln Cys Met Ala Leu Val Arg Asp Glu Cys Leu 
            180                 185                 190         


Leu Pro Cys Lys Asp Ala Pro Glu Leu Gly Tyr Ala Lys Glu Ser Ser 
        195                 200                 205             


Ser Glu Gln Tyr Val Pro Asp Val Phe Tyr Lys Asp Val Asp Lys Phe 
    210                 215                 220                 


Gly Asn Glu Ile Thr Gln Leu Ala Arg Pro Leu Pro Val Glu Tyr Leu 
225                 230                 235                 240 


Ile Ile Asp Ile Thr Thr Thr Phe Pro Lys Asp Pro Val Tyr Thr Phe 
                245                 250                 255     


Ser Ile Ser Gln Asn Pro Phe Pro Ile Glu Asn Arg Asp Val Leu Gly 
            260                 265                 270         


Glu Thr Gln Asp Phe His Ser Leu Ala Thr Tyr Leu Ser Gln Asn Thr 
        275                 280                 285             


Ser Ser Val Phe Leu Asp Thr Ile Ser Asp Phe His Leu Leu Leu Phe 
    290                 295                 300                 


Leu Val Thr Asn Glu Val Met Pro Leu Gln Asp Ser Ile Ser Leu Leu 
305                 310                 315                 320 


Leu Glu Ala Val Arg Thr Arg Asn Glu Glu Leu Ala Gln Thr Trp Lys 
                325                 330                 335     


Arg Ser Glu Gln Trp Ala Thr Ile Glu Gln Leu Cys Ser Thr Val Gly 
            340                 345                 350         


Gly Gln Leu Pro Gly Leu His Glu Tyr Gly Ala Val Gly Gly Ser Thr 
        355                 360                 365             


His Thr Ala Thr Ala Ala Met Trp Ala Cys Gln His Cys Thr Phe Met 
    370                 375                 380                 


Asn Gln Pro Gly Thr Gly His Cys Glu Met Cys Ser Leu Pro Arg Thr 
385                 390                 395                 400 


<210> 212
<211> 203
<212> PRT
<213> Homo sapiens

<400> 212
Thr Gln Ala Tyr Cys Lys Met Val Leu His Gly Ala Lys Tyr Pro His 
1               5                   10                  15      


Cys Ala Val Asn Gly Leu Leu Val Ala Glu Lys Gln Lys Pro Arg Lys 
            20                  25                  30          


Glu His Leu Pro Leu Gly Gly Pro Gly Ala His His Thr Leu Phe Val 
        35                  40                  45              


Asp Cys Ile Pro Leu Phe His Gly Thr Leu Ala Leu Ala Pro Met Leu 
    50                  55                  60                  


Glu Val Ala Leu Thr Leu Ile Asp Ser Trp Cys Lys Asp His Ser Tyr 
65                  70                  75                  80  


Val Ile Ala Gly Tyr Tyr Gln Ala Asn Glu Arg Val Lys Asp Ala Ser 
                85                  90                  95      


Pro Asn Gln Val Ala Glu Lys Val Ala Ser Arg Ile Ala Glu Gly Phe 
            100                 105                 110         


Ser Asp Thr Ala Leu Ile Met Val Asp Asn Thr Lys Phe Thr Met Asp 
        115                 120                 125             


Cys Val Ala Pro Thr Ile His Val Tyr Glu His His Glu Asn Arg Trp 
    130                 135                 140                 


Arg Cys Arg Asp Pro His His Asp Tyr Cys Glu Asp Trp Pro Glu Ala 
145                 150                 155                 160 


Gln Arg Ile Ser Ala Ser Leu Leu Asp Ser Arg Ser Tyr Glu Thr Leu 
                165                 170                 175     


Val Asp Phe Asp Asn His Leu Asp Asp Ile Arg Asn Asp Trp Thr Asn 
            180                 185                 190         


Pro Glu Ile Asn Lys Ala Val Leu His Leu Cys 
        195                 200             


<210> 213
<211> 398
<212> PRT
<213> Homo sapiens

<400> 213
Gly Phe Val Leu Gly Ala Leu Ala Phe Gln His Leu Asn Thr Asp Ser 
1               5                   10                  15      


Asp Thr Glu Gly Phe Leu Leu Gly Glu Val Lys Gly Glu Ala Lys Asn 
            20                  25                  30          


Ser Ile Thr Asp Ser Gln Met Asp Asp Val Glu Val Val Tyr Thr Ile 
        35                  40                  45              


Asp Ile Gln Lys Tyr Ile Pro Cys Tyr Gln Leu Phe Ser Phe Tyr Asn 
    50                  55                  60                  


Ser Ser Gly Glu Val Asn Glu Gln Ala Leu Lys Lys Ile Leu Ser Asn 
65                  70                  75                  80  


Val Lys Lys Asn Val Val Gly Trp Tyr Lys Phe Arg Arg His Ser Asp 
                85                  90                  95      


Gln Ile Met Thr Phe Arg Glu Arg Leu Leu His Lys Asn Leu Gln Glu 
            100                 105                 110         


His Phe Ser Asn Gln Asp Leu Val Phe Leu Leu Leu Thr Pro Ser Ile 
        115                 120                 125             


Ile Thr Glu Ser Cys Ser Thr His Arg Leu Glu His Ser Leu Tyr Lys 
    130                 135                 140                 


Pro Gln Lys Gly Leu Phe His Arg Val Pro Leu Val Val Ala Asn Leu 
145                 150                 155                 160 


Gly Met Ser Glu Gln Leu Gly Tyr Lys Thr Val Ser Gly Ser Cys Met 
                165                 170                 175     


Ser Thr Gly Phe Ser Arg Ala Val Gln Thr His Ser Ser Lys Phe Phe 
            180                 185                 190         


Glu Glu Asp Gly Ser Leu Lys Glu Val His Lys Ile Asn Glu Met Tyr 
        195                 200                 205             


Ala Ser Leu Gln Glu Glu Leu Lys Ser Ile Cys Lys Lys Val Glu Asp 
    210                 215                 220                 


Ser Glu Gln Ala Val Asp Lys Leu Val Lys Asp Val Asn Arg Leu Lys 
225                 230                 235                 240 


Arg Glu Ile Glu Lys Arg Arg Gly Ala Gln Ile Gln Ala Ala Arg Glu 
                245                 250                 255     


Lys Asn Ile Gln Lys Asp Pro Gln Glu Asn Ile Phe Leu Cys Gln Ala 
            260                 265                 270         


Leu Arg Thr Phe Phe Pro Asn Ser Glu Phe Leu His Ser Cys Val Met 
        275                 280                 285             


Ser Leu Lys Asn Arg His Val Ser Lys Ser Ser Cys Asn Tyr Asn His 
    290                 295                 300                 


His Leu Asp Val Val Asp Asn Leu Thr Leu Met Val Glu His Thr Asp 
305                 310                 315                 320 


Ile Pro Glu Ala Ser Pro Ala Ser Thr Pro Gln Ile Ile Lys His Lys 
                325                 330                 335     


Ala Leu Asp Leu Asp Asp Arg Trp Gln Phe Lys Arg Ser Arg Leu Leu 
            340                 345                 350         


Asp Thr Gln Asp Lys Arg Ser Lys Ala Asp Thr Gly Ser Ser Asn Gln 
        355                 360                 365             


Asp Lys Ala Ser Lys Met Ser Ser Pro Glu Thr Asp Glu Glu Ile Glu 
    370                 375                 380                 


Lys Met Lys Gly Phe Gly Glu Tyr Ser Arg Ser Pro Thr Phe 
385                 390                 395             


<210> 214
<211> 168
<212> PRT
<213> Homo sapiens

<400> 214
Val Val Leu Pro Glu Asp Leu Cys His Lys Phe Leu Gln Leu Ala Glu 
1               5                   10                  15      


Ser Asn Thr Val Arg Gly Ile Glu Thr Cys Gly Ile Leu Cys Gly Lys 
            20                  25                  30          


Leu Thr His Asn Glu Phe Thr Ile Thr His Val Ile Val Pro Lys Gln 
        35                  40                  45              


Ser Ala Gly Pro Asp Tyr Cys Asp Met Glu Asn Val Glu Glu Leu Phe 
    50                  55                  60                  


Asn Val Gln Asp Gln His Asp Leu Leu Thr Leu Gly Trp Ile His Thr 
65                  70                  75                  80  


His Pro Thr Gln Thr Ala Phe Leu Ser Ser Val Asp Leu His Thr His 
                85                  90                  95      


Cys Ser Tyr Gln Leu Met Leu Pro Glu Ala Ile Ala Ile Val Cys Ser 
            100                 105                 110         


Pro Lys His Lys Asp Thr Gly Ile Phe Arg Leu Thr Asn Ala Gly Met 
        115                 120                 125             


Leu Glu Val Ser Ala Cys Lys Lys Lys Gly Phe His Pro His Thr Lys 
    130                 135                 140                 


Glu Pro Arg Leu Phe Ser Ile Cys Lys His Val Leu Val Lys Asp Ile 
145                 150                 155                 160 


Lys Ile Ile Val Leu Asp Leu Arg 
                165             


<210> 215
<211> 287
<212> PRT
<213> Homo sapiens

<400> 215
Val Ala Leu His Pro Leu Val Ile Leu Asn Ile Ser Asp His Trp Ile 
1               5                   10                  15      


Arg Met Arg Ser Gln Glu Gly Arg Pro Val Gln Val Ile Gly Ala Leu 
            20                  25                  30          


Ile Gly Lys Gln Glu Gly Arg Asn Ile Glu Val Met Asn Ser Phe Glu 
        35                  40                  45              


Leu Leu Ser His Thr Val Glu Glu Lys Ile Ile Ile Asp Lys Glu Tyr 
    50                  55                  60                  


Tyr Tyr Thr Lys Glu Glu Gln Phe Lys Gln Val Phe Lys Glu Leu Glu 
65                  70                  75                  80  


Phe Leu Gly Trp Tyr Thr Thr Gly Gly Pro Pro Asp Pro Ser Asp Ile 
                85                  90                  95      


His Val His Lys Gln Val Cys Glu Ile Ile Glu Ser Pro Leu Phe Leu 
            100                 105                 110         


Lys Leu Asn Pro Met Thr Lys His Thr Asp Leu Pro Val Ser Val Phe 
        115                 120                 125             


Glu Ser Val Ile Asp Ile Ile Asn Gly Glu Ala Thr Met Leu Phe Ala 
    130                 135                 140                 


Glu Leu Thr Tyr Thr Leu Ala Thr Glu Glu Ala Glu Arg Ile Gly Val 
145                 150                 155                 160 


Asp His Val Ala Arg Met Thr Ala Thr Gly Ser Gly Glu Asn Ser Thr 
                165                 170                 175     


Val Ala Glu His Leu Ile Ala Gln His Ser Ala Ile Lys Met Leu His 
            180                 185                 190         


Ser Arg Val Lys Leu Ile Leu Glu Tyr Val Lys Ala Ser Glu Ala Gly 
        195                 200                 205             


Glu Val Pro Phe Asn His Glu Ile Leu Arg Glu Ala Tyr Ala Leu Cys 
    210                 215                 220                 


His Cys Leu Pro Val Leu Ser Thr Asp Lys Phe Lys Thr Asp Phe Tyr 
225                 230                 235                 240 


Asp Gln Cys Asn Asp Val Gly Leu Met Ala Tyr Leu Gly Thr Ile Thr 
                245                 250                 255     


Lys Thr Cys Asn Thr Met Asn Gln Phe Val Asn Lys Phe Asn Val Leu 
            260                 265                 270         


Tyr Asp Arg Gln Gly Ile Gly Arg Arg Met Arg Gly Leu Phe Phe 
        275                 280                 285         


<210> 216
<211> 266
<212> PRT
<213> Homo sapiens

<400> 216
Val Arg Leu His Pro Val Ile Leu Ala Ser Ile Val Asp Ser Tyr Glu 
1               5                   10                  15      


Arg Arg Asn Glu Gly Ala Ala Arg Val Ile Gly Thr Leu Leu Gly Thr 
            20                  25                  30          


Val Asp Lys His Ser Val Glu Val Thr Asn Cys Phe Ser Val Pro His 
        35                  40                  45              


Asn Glu Ser Glu Asp Glu Val Ala Val Asp Met Glu Phe Ala Lys Asn 
    50                  55                  60                  


Met Tyr Glu Leu His Lys Lys Val Ser Pro Asn Glu Leu Ile Leu Gly 
65                  70                  75                  80  


Trp Tyr Ala Thr Gly His Asp Ile Thr Glu His Ser Val Leu Ile His 
                85                  90                  95      


Glu Tyr Tyr Ser Arg Glu Ala Pro Asn Pro Ile His Leu Thr Val Asp 
            100                 105                 110         


Thr Ser Leu Gln Asn Gly Arg Met Ser Ile Lys Ala Tyr Val Ser Thr 
        115                 120                 125             


Leu Met Gly Val Pro Gly Arg Thr Met Gly Val Met Phe Thr Pro Leu 
    130                 135                 140                 


Thr Val Lys Tyr Ala Tyr Tyr Asp Thr Glu Arg Ile Gly Val Asp Leu 
145                 150                 155                 160 


Ile Met Lys Thr Cys Phe Ser Pro Asn Arg Val Ile Gly Leu Ser Ser 
                165                 170                 175     


Asp Leu Gln Gln Val Gly Gly Ala Ser Ala Arg Ile Gln Asp Ala Leu 
            180                 185                 190         


Ser Thr Val Leu Gln Tyr Ala Glu Asp Val Leu Ser Gly Lys Val Ser 
        195                 200                 205             


Ala Asp Asn Thr Val Gly Arg Phe Leu Met Ser Leu Val Asn Gln Val 
    210                 215                 220                 


Pro Lys Ile Val Pro Asp Asp Phe Glu Thr Met Leu Asn Ser Asn Ile 
225                 230                 235                 240 


Asn Asp Leu Leu Met Val Thr Tyr Leu Ala Asn Leu Thr Gln Ser Gln 
                245                 250                 255     


Ile Ala Leu Asn Glu Lys Leu Val Asn Leu 
            260                 265     


<210> 217
<211> 316
<212> PRT
<213> Homo sapiens

<400> 217
Val Val Val His Pro Leu Val Leu Leu Ser Val Val Asp His Phe Asn 
1               5                   10                  15      


Arg Ile Gly Lys Val Gly Asn Gln Lys Arg Val Val Gly Val Leu Leu 
            20                  25                  30          


Gly Ser Trp Gln Lys Lys Val Leu Asp Val Ser Asn Ser Phe Ala Val 
        35                  40                  45              


Pro Phe Asp Glu Asp Asp Lys Asp Asp Ser Val Trp Phe Leu Asp His 
    50                  55                  60                  


Asp Tyr Leu Glu Asn Met Tyr Gly Met Phe Lys Lys Val Asn Ala Arg 
65                  70                  75                  80  


Glu Arg Ile Val Gly Trp Tyr His Thr Gly Pro Lys Leu His Lys Asn 
                85                  90                  95      


Asp Ile Ala Ile Asn Glu Leu Met Lys Arg Tyr Cys Pro Asn Ser Val 
            100                 105                 110         


Leu Val Ile Ile Asp Val Lys Pro Lys Asp Leu Gly Leu Pro Thr Glu 
        115                 120                 125             


Ala Tyr Ile Ser Val Glu Glu Val His Asp Asp Gly Thr Pro Thr Ser 
    130                 135                 140                 


Lys Thr Phe Glu His Val Thr Ser Glu Ile Gly Ala Glu Glu Ala Glu 
145                 150                 155                 160 


Glu Val Gly Val Glu His Leu Leu Arg Asp Ile Lys Asp Thr Thr Val 
                165                 170                 175     


Gly Thr Leu Ser Gln Arg Ile Thr Asn Gln Val His Gly Leu Lys Gly 
            180                 185                 190         


Leu Asn Ser Lys Leu Leu Asp Ile Arg Ser Tyr Leu Glu Lys Val Ala 
        195                 200                 205             


Thr Gly Lys Leu Pro Ile Asn His Gln Ile Ile Tyr Gln Leu Gln Asp 
    210                 215                 220                 


Val Phe Asn Leu Leu Pro Asp Val Ser Leu Gln Glu Phe Val Lys Ala 
225                 230                 235                 240 


Phe Tyr Leu Lys Thr Asn Asp Gln Met Val Val Val Tyr Leu Ala Ser 
                245                 250                 255     


Leu Ile Arg Ser Val Val Ala Leu His Asn Leu Ile Asn Asn Lys Ile 
            260                 265                 270         


Ala Asn Arg Asp Ala Glu Lys Lys Glu Gly Gln Glu Lys Glu Glu Ser 
        275                 280                 285             


Lys Lys Asp Arg Lys Glu Asp Lys Glu Lys Asp Lys Asp Lys Glu Lys 
    290                 295                 300                 


Ser Asp Val Lys Lys Glu Glu Lys Lys Glu Lys Lys 
305                 310                 315     


<210> 218
<211> 314
<212> PRT
<213> Homo sapiens

<400> 218
Val Gln Ile Asp Gly Leu Val Val Leu Lys Ile Ile Lys His Tyr Gln 
1               5                   10                  15      


Glu Glu Gly Gln Gly Thr Glu Val Val Gln Gly Val Leu Leu Gly Leu 
            20                  25                  30          


Val Val Glu Asp Arg Leu Glu Ile Thr Asn Cys Phe Pro Phe Pro Gln 
        35                  40                  45              


His Thr Glu Asp Asp Ala Asp Phe Asp Glu Val Gln Tyr Gln Met Glu 
    50                  55                  60                  


Met Met Arg Ser Leu Arg His Val Asn Ile Asp His Leu His Val Gly 
65                  70                  75                  80  


Trp Tyr Gln Ser Thr Tyr Tyr Gly Ser Phe Val Thr Arg Ala Leu Leu 
                85                  90                  95      


Asp Ser Gln Phe Ser Tyr Gln His Ala Ile Glu Glu Ser Val Val Leu 
            100                 105                 110         


Ile Tyr Asp Pro Ile Lys Thr Ala Gln Gly Ser Leu Ser Leu Lys Ala 
        115                 120                 125             


Tyr Arg Leu Thr Pro Lys Leu Met Glu Val Cys Lys Glu Lys Asp Phe 
    130                 135                 140                 


Ser Pro Glu Ala Leu Lys Lys Ala Asn Ile Thr Phe Glu Tyr Met Phe 
145                 150                 155                 160 


Glu Glu Val Pro Ile Val Ile Lys Asn Ser His Leu Ile Asn Val Leu 
                165                 170                 175     


Met Trp Glu Leu Glu Lys Lys Ser Ala Val Ala Asp Lys His Glu Leu 
            180                 185                 190         


Leu Ser Leu Ala Ser Ser Asn His Leu Gly Lys Asn Leu Gln Leu Leu 
        195                 200                 205             


Met Asp Arg Val Asp Glu Met Ser Gln Asp Ile Val Lys Tyr Asn Thr 
    210                 215                 220                 


Tyr Met Arg Asn Thr Ser Lys Gln Gln Gln Gln Lys His Gln Tyr Gln 
225                 230                 235                 240 


Gln Arg Arg Gln Gln Glu Asn Met Gln Arg Gln Ser Arg Gly Glu Pro 
                245                 250                 255     


Pro Leu Pro Glu Glu Asp Leu Ser Lys Leu Phe Lys Pro Pro Gln Pro 
            260                 265                 270         


Pro Ala Arg Met Asp Ser Leu Leu Ile Ala Gly Gln Ile Asn Thr Tyr 
        275                 280                 285             


Cys Gln Asn Ile Lys Glu Phe Thr Ala Gln Asn Leu Gly Lys Leu Phe 
    290                 295                 300                 


Met Ala Gln Ala Leu Gln Glu Tyr Asn Asn 
305                 310                 


<210> 219
<211> 281
<212> PRT
<213> Homo sapiens

<400> 219
Tyr Cys Lys Ile Ser Ala Leu Ala Leu Leu Lys Met Val Met His Ala 
1               5                   10                  15      


Arg Ser Gly Gly Asn Leu Glu Val Met Gly Leu Met Leu Gly Lys Val 
            20                  25                  30          


Asp Gly Glu Thr Met Ile Ile Met Asp Ser Phe Ala Leu Pro Val Glu 
        35                  40                  45              


Gly Thr Glu Thr Arg Val Asn Ala Gln Ala Ala Ala Tyr Glu Tyr Met 
    50                  55                  60                  


Ala Ala Tyr Ile Glu Asn Ala Lys Gln Val Gly Arg Leu Glu Asn Ala 
65                  70                  75                  80  


Ile Gly Trp Tyr His Ser His Pro Gly Tyr Gly Cys Trp Leu Ser Gly 
                85                  90                  95      


Ile Asp Val Ser Thr Gln Met Leu Asn Gln Gln Phe Gln Glu Pro Phe 
            100                 105                 110         


Val Ala Val Val Ile Asp Pro Thr Arg Thr Ile Ser Ala Gly Lys Val 
        115                 120                 125             


Asn Leu Gly Ala Phe Arg Thr Tyr Pro Lys Gly Tyr Lys Pro Pro Asp 
    130                 135                 140                 


Glu Gly Pro Ser Glu Tyr Gln Thr Ile Pro Leu Asn Lys Ile Glu Asp 
145                 150                 155                 160 


Phe Gly Val His Cys Lys Gln Tyr Tyr Ala Leu Glu Val Ser Tyr Phe 
                165                 170                 175     


Lys Ser Ser Leu Asp Arg Lys Leu Leu Glu Leu Leu Trp Asn Lys Tyr 
            180                 185                 190         


Trp Val Asn Thr Leu Ser Ser Ser Ser Leu Leu Thr Asn Ala Asp Tyr 
        195                 200                 205             


Thr Thr Gly Gln Val Phe Asp Leu Ser Glu Lys Leu Glu Gln Ser Glu 
    210                 215                 220                 


Ala Gln Leu Gly Arg Gly Ser Phe Met Leu Gly Leu Glu Thr His Asp 
225                 230                 235                 240 


Arg Lys Ser Glu Asp Lys Leu Ala Lys Ala Thr Arg Asp Ser Cys Lys 
                245                 250                 255     


Thr Thr Ile Glu Ala Ile His Gly Leu Met Ser Gln Val Ile Lys Asp 
            260                 265                 270         


Lys Leu Phe Asn Gln Ile Asn Ile Ser 
        275                 280     


<210> 220
<211> 305
<212> PRT
<213> Homo sapiens

<400> 220
Val His Leu Glu Ser Asp Ala Phe Leu Val Cys Leu Asn His Ala Leu 
1               5                   10                  15      


Ser Thr Glu Lys Glu Glu Val Met Gly Leu Cys Ile Gly Glu Leu Asn 
            20                  25                  30          


Asp Asp Thr Arg Ser Asp Ser Lys Phe Ala Tyr Thr Gly Thr Glu Met 
        35                  40                  45              


Arg Thr Val Ala Glu Lys Val Asp Ala Val Arg Ile Val His Ile His 
    50                  55                  60                  


Ser Val Ile Ile Leu Arg Arg Ser Asp Lys Arg Lys Asp Arg Val Glu 
65                  70                  75                  80  


Ile Ser Pro Glu Gln Leu Ser Ala Ala Ser Thr Glu Ala Glu Arg Leu 
                85                  90                  95      


Ala Glu Leu Thr Gly Arg Pro Met Arg Val Val Gly Trp Tyr His Ser 
            100                 105                 110         


His Pro His Ile Thr Val Trp Pro Ser His Val Asp Val Arg Thr Gln 
        115                 120                 125             


Ala Met Tyr Gln Met Met Asp Gln Gly Phe Val Gly Leu Ile Phe Ser 
    130                 135                 140                 


Cys Phe Ile Glu Asp Lys Asn Thr Lys Thr Gly Arg Val Leu Tyr Thr 
145                 150                 155                 160 


Cys Phe Gln Ser Ile Gln Ala Gln Lys Ser Ser Glu Ser Leu His Gly 
                165                 170                 175     


Pro Arg Asp Phe Trp Ser Ser Ser Gln His Ile Ser Ile Glu Gly Gln 
            180                 185                 190         


Lys Glu Glu Glu Arg Tyr Glu Arg Ile Glu Ile Pro Ile His Ile Val 
        195                 200                 205             


Pro His Val Thr Ile Gly Lys Val Cys Leu Glu Ser Ala Val Glu Leu 
    210                 215                 220                 


Pro Lys Ile Leu Cys Gln Glu Glu Gln Asp Ala Tyr Arg Arg Ile His 
225                 230                 235                 240 


Ser Leu Thr His Leu Asp Ser Val Thr Lys Ile His Asn Gly Ser Val 
                245                 250                 255     


Phe Thr Lys Asn Leu Cys Ser Gln Met Ser Ala Val Ser Gly Pro Leu 
            260                 265                 270         


Leu Gln Trp Leu Glu Asp Arg Leu Glu Gln Asn Gln Gln His Leu Gln 
        275                 280                 285             


Glu Leu Gln Gln Glu Lys Glu Glu Leu Met Gln Glu Leu Ser Ser Leu 
    290                 295                 300                 


Glu 
305 


<210> 221
<211> 1828
<212> PRT
<213> Homo sapiens

<400> 221
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp 
            20                  25                  30          


Ser Gly Ser Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly 
        35                  40                  45              


His Gly Ser Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser 
    50                  55                  60                  


Glu Ser Glu Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro 
65                  70                  75                  80  


Glu Ala Lys Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val 
                85                  90                  95      


Lys Lys Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser 
            100                 105                 110         


Asn Arg Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala 
        115                 120                 125             


Ser Ser Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln 
    130                 135                 140                 


Leu Lys Lys Gln Glu Lys Trp Lys Gln Glu Pro Ser Glu Asp Glu Gln 
145                 150                 155                 160 


Glu Gln Gly Thr Ser Ala Glu Ser Glu Pro Glu Gln Lys Lys Val Lys 
                165                 170                 175     


Ala Arg Arg Pro Val Pro Arg Arg Thr Val Pro Lys Pro Arg Val Lys 
            180                 185                 190         


Lys Gln Pro Lys Thr Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser 
        195                 200                 205             


Asp Glu Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Thr Arg Arg 
    210                 215                 220                 


Arg Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Thr 
225                 230                 235                 240 


Asp Ser Asp Asp Leu Ile Glu Met Thr Gly Glu Gly Val Asp Glu Gln 
                245                 250                 255     


Gln Asp Asn Ser Glu Thr Ile Glu Lys Val Leu Asp Ser Arg Leu Gly 
            260                 265                 270         


Lys Lys Gly Ala Thr Gly Ala Ser Thr Thr Val Tyr Ala Ile Glu Ala 
        275                 280                 285             


Asn Gly Asp Pro Ser Gly Asp Phe Asp Thr Glu Lys Asp Glu Gly Glu 
    290                 295                 300                 


Ile Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Thr 
305                 310                 315                 320 


Trp Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys 
                325                 330                 335     


Lys Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu 
            340                 345                 350         


Gly Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu 
        355                 360                 365             


Leu Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile 
    370                 375                 380                 


Ala Val Lys Thr Ser Lys Ser Thr Leu Gly Gln Thr Asp Phe Pro Ala 
385                 390                 395                 400 


His Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys 
                405                 410                 415     


Trp Met Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu 
            420                 425                 430         


Ile Gly Lys Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn 
        435                 440                 445             


Asn Ser Lys Thr Ile Pro Thr Arg Glu Cys Lys Ala Leu Lys Gln Arg 
    450                 455                 460                 


Pro Arg Phe Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu 
465                 470                 475                 480 


Asn Leu Glu Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala 
                485                 490                 495     


His Ser Trp Cys Lys Asn Asn Ser Val Ile Leu Ala Asp Glu Met Gly 
            500                 505                 510         


Leu Gly Lys Thr Ile Gln Thr Ile Ser Phe Leu Ser Tyr Leu Phe His 
        515                 520                 525             


Gln His Gln Leu Tyr Gly Pro Phe Leu Ile Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Leu Thr Ser Trp Gln Arg Glu Phe Glu Ile Trp Ala Pro Glu Ile Asn 
545                 550                 555                 560 


Val Val Val Tyr Ile Gly Asp Leu Met Ser Arg Asn Thr Ile Arg Glu 
                565                 570                 575     


Tyr Glu Trp Ile His Ser Gln Thr Lys Arg Leu Lys Phe Asn Ala Leu 
            580                 585                 590         


Ile Thr Thr Tyr Glu Ile Leu Leu Lys Asp Lys Thr Val Leu Gly Ser 
        595                 600                 605             


Ile Asn Trp Ala Phe Leu Gly Val Asp Glu Ala His Arg Leu Lys Asn 
    610                 615                 620                 


Asp Asp Ser Leu Leu Tyr Lys Thr Leu Ile Asp Phe Lys Ser Asn His 
625                 630                 635                 640 


Arg Leu Leu Ile Thr Gly Thr Pro Leu Gln Asn Ser Leu Lys Glu Leu 
                645                 650                 655     


Trp Ser Leu Leu His Phe Ile Met Pro Glu Lys Phe Glu Phe Trp Glu 
            660                 665                 670         


Asp Phe Glu Glu Asp His Gly Lys Gly Arg Glu Asn Gly Tyr Gln Ser 
        675                 680                 685             


Leu His Lys Val Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp 
    690                 695                 700                 


Val Glu Lys Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Val Glu 
705                 710                 715                 720 


Met Ser Ala Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Thr Arg Asn 
                725                 730                 735     


Tyr Lys Ala Leu Ala Lys Gly Thr Arg Gly Ser Thr Ser Gly Phe Leu 
            740                 745                 750         


Asn Ile Val Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile 
        755                 760                 765             


Lys Pro Pro Glu Glu Asn Glu Arg Glu Asn Gly Gln Glu Ile Leu Leu 
    770                 775                 780                 


Ser Leu Ile Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu 
785                 790                 795                 800 


Thr Arg Leu Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met 
                805                 810                 815     


Val Arg Met Leu Asp Ile Leu Ala Glu Tyr Leu Thr Ile Lys His Tyr 
            820                 825                 830         


Pro Phe Gln Arg Leu Asp Gly Ser Ile Lys Gly Glu Ile Arg Lys Gln 
        835                 840                 845             


Ala Leu Asp His Phe Asn Ala Asp Gly Ser Glu Asp Phe Cys Phe Leu 
    850                 855                 860                 


Leu Ser Thr Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp 
865                 870                 875                 880 


Thr Val Val Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln 
                885                 890                 895     


Ala Gln Ala Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile 
            900                 905                 910         


Tyr Arg Leu Val Thr Lys Gly Thr Val Glu Glu Glu Ile Ile Glu Arg 
        915                 920                 925             


Ala Lys Lys Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp 
    930                 935                 940                 


Thr Thr Gly Arg Thr Ile Leu Glu Asn Asn Ser Gly Arg Ser Asn Ser 
945                 950                 955                 960 


Asn Pro Phe Asn Lys Glu Glu Leu Thr Ala Ile Leu Lys Phe Gly Ala 
                965                 970                 975     


Glu Asp Leu Phe Lys Glu Leu Glu Gly Glu Glu Ser Glu Pro Gln Glu 
            980                 985                 990         


Met Asp Ile Asp Glu Ile Leu Arg  Leu Ala Glu Thr Arg  Glu Asn Glu 
        995                 1000                 1005             


Val Ser  Thr Ser Ala Thr Asp  Glu Leu Leu Ser Gln  Phe Lys Val 
    1010                 1015                 1020             


Ala Asn  Phe Ala Thr Met Glu  Asp Glu Glu Glu Leu  Glu Glu Arg 
    1025                 1030                 1035             


Pro His  Lys Asp Trp Asp Glu  Ile Ile Pro Glu Glu  Gln Arg Lys 
    1040                 1045                 1050             


Lys Val  Glu Glu Glu Glu Arg  Gln Lys Glu Leu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Met Leu  Pro Arg Ile Arg Ser  Ser Thr Lys Lys Ala  Gln Thr Asn 
    1070                 1075                 1080             


Asp Ser  Asp Ser Asp Thr Glu  Ser Lys Arg Gln Ala  Gln Arg Ser 
    1085                 1090                 1095             


Ser Ala  Ser Glu Ser Glu Thr  Glu Asp Ser Asp Asp  Asp Lys Lys 
    1100                 1105                 1110             


Pro Lys  Arg Arg Gly Arg Pro  Arg Ser Val Arg Lys  Asp Leu Val 
    1115                 1120                 1125             


Glu Gly  Phe Thr Asp Ala Glu  Ile Arg Arg Phe Ile  Lys Ala Tyr 
    1130                 1135                 1140             


Lys Lys  Phe Gly Leu Pro Leu  Glu Arg Leu Glu Cys  Ile Ala Arg 
    1145                 1150                 1155             


Asp Ala  Glu Leu Val Asp Lys  Ser Val Ala Asp Leu  Lys Arg Leu 
    1160                 1165                 1170             


Gly Glu  Leu Ile His Asn Ser  Cys Val Ser Ala Met  Gln Glu Tyr 
    1175                 1180                 1185             


Glu Glu  Gln Leu Lys Glu Asn  Ala Ser Glu Gly Lys  Gly Pro Gly 
    1190                 1195                 1200             


Lys Arg  Arg Gly Pro Thr Ile  Lys Ile Ser Gly Val  Gln Val Asn 
    1205                 1210                 1215             


Val Lys  Ser Ile Ile Gln His  Glu Glu Glu Phe Glu  Met Leu His 
    1220                 1225                 1230             


Lys Ser  Ile Pro Val Asp Pro  Glu Glu Lys Lys Lys  Tyr Cys Leu 
    1235                 1240                 1245             


Thr Cys  Arg Val Lys Ala Ala  His Phe Asp Val Glu  Trp Gly Val 
    1250                 1255                 1260             


Glu Asp  Asp Ser Arg Leu Leu  Leu Gly Ile Tyr Glu  His Gly Tyr 
    1265                 1270                 1275             


Gly Asn  Trp Glu Leu Ile Lys  Thr Asp Pro Glu Leu  Lys Leu Thr 
    1280                 1285                 1290             


Asp Lys  Ile Leu Pro Val Glu  Thr Asp Lys Lys Pro  Gln Gly Lys 
    1295                 1300                 1305             


Gln Leu  Gln Thr Arg Ala Asp  Tyr Leu Leu Lys Leu  Leu Arg Lys 
    1310                 1315                 1320             


Gly Leu  Glu Lys Lys Gly Ala  Val Thr Gly Gly Glu  Glu Ala Lys 
    1325                 1330                 1335             


Leu Lys  Lys Arg Lys Pro Arg  Val Lys Lys Glu Asn  Lys Val Pro 
    1340                 1345                 1350             


Arg Leu  Lys Glu Glu His Gly  Ile Glu Leu Ser Ser  Pro Arg His 
    1355                 1360                 1365             


Ser Asp  Asn Pro Ser Glu Glu  Gly Glu Val Lys Asp  Asp Gly Leu 
    1370                 1375                 1380             


Glu Lys  Ser Pro Met Lys Lys  Lys Gln Lys Lys Lys  Glu Asn Lys 
    1385                 1390                 1395             


Glu Asn  Lys Glu Lys Gln Met  Ser Ser Arg Lys Asp  Lys Glu Gly 
    1400                 1405                 1410             


Asp Lys  Glu Arg Lys Lys Ser  Lys Asp Lys Lys Glu  Lys Pro Lys 
    1415                 1420                 1425             


Ser Gly  Asp Ala Lys Ser Ser  Ser Lys Ser Lys Arg  Ser Gln Gly 
    1430                 1435                 1440             


Pro Val  His Ile Thr Ala Gly  Ser Glu Pro Val Pro  Ile Gly Glu 
    1445                 1450                 1455             


Asp Glu  Asp Asp Asp Leu Asp  Gln Glu Thr Phe Ser  Ile Cys Lys 
    1460                 1465                 1470             


Glu Arg  Met Arg Pro Val Lys  Lys Ala Leu Lys Gln  Leu Asp Lys 
    1475                 1480                 1485             


Pro Asp  Lys Gly Leu Asn Val  Gln Glu Gln Leu Glu  His Thr Arg 
    1490                 1495                 1500             


Asn Cys  Leu Leu Lys Ile Gly  Asp Arg Ile Ala Glu  Cys Leu Lys 
    1505                 1510                 1515             


Ala Tyr  Ser Asp Gln Glu His  Ile Lys Leu Trp Arg  Arg Asn Leu 
    1520                 1525                 1530             


Trp Ile  Phe Val Ser Lys Phe  Thr Glu Phe Asp Ala  Arg Lys Leu 
    1535                 1540                 1545             


His Lys  Leu Tyr Lys Met Ala  His Lys Lys Arg Ser  Gln Glu Glu 
    1550                 1555                 1560             


Glu Glu  Gln Lys Lys Lys Asp  Asp Val Thr Gly Gly  Lys Lys Pro 
    1565                 1570                 1575             


Phe Arg  Pro Glu Ala Ser Gly  Ser Ser Arg Asp Ser  Leu Ile Ser 
    1580                 1585                 1590             


Gln Ser  His Thr Ser His Asn  Leu His Pro Gln Lys  Pro His Leu 
    1595                 1600                 1605             


Pro Ala  Ser His Gly Pro Gln  Met His Gly His Pro  Arg Asp Asn 
    1610                 1615                 1620             


Tyr Asn  His Pro Asn Lys Arg  His Phe Ser Asn Ala  Asp Arg Gly 
    1625                 1630                 1635             


Asp Trp  Gln Arg Glu Arg Lys  Phe Asn Tyr Gly Gly  Gly Asn Asn 
    1640                 1645                 1650             


Asn Pro  Pro Trp Gly Ser Asp  Arg His His Gln Tyr  Glu Gln His 
    1655                 1660                 1665             


Trp Tyr  Lys Asp His His Tyr  Gly Asp Arg Arg His  Met Asp Ala 
    1670                 1675                 1680             


His Arg  Ser Gly Ser Tyr Arg  Pro Asn Asn Met Ser  Arg Lys Arg 
    1685                 1690                 1695             


Pro Tyr  Asp Gln Tyr Ser Ser  Asp Arg Asp His Arg  Gly His Arg 
    1700                 1705                 1710             


Asp Tyr  Tyr Asp Arg His His  His Asp Ser Lys Arg  Arg Arg Ser 
    1715                 1720                 1725             


Asp Glu  Phe Arg Pro Gln Asn  Tyr His Gln Gln Asp  Phe Arg Arg 
    1730                 1735                 1740             


Met Ser  Asp His Arg Pro Ala  Met Gly Tyr His Gly  Gln Gly Pro 
    1745                 1750                 1755             


Ser Asp  His Tyr Arg Ser Phe  His Thr Asp Lys Leu  Gly Glu Tyr 
    1760                 1765                 1770             


Lys Gln  Pro Leu Pro Pro Leu  His Pro Ala Val Ser  Asp Pro Arg 
    1775                 1780                 1785             


Ser Pro  Pro Ser Gln Lys Ser  Pro His Asp Ser Lys  Ser Pro Leu 
    1790                 1795                 1800             


Asp His  Arg Ser Pro Leu Glu  Arg Ser Leu Glu Gln  Lys Asn Asn 
    1805                 1810                 1815             


Pro Asp  Tyr Asn Trp Asn Val  Arg Lys Thr 
    1820                 1825             


<210> 222
<211> 1566
<212> PRT
<213> Homo sapiens

<400> 222
Met Thr Ala Asp Lys Asp Lys Asp Lys Asp Lys Glu Lys Asp Arg Asp 
1               5                   10                  15      


Arg Asp Arg Asp Arg Glu Arg Glu Lys Arg Asp Lys Ala Arg Glu Ser 
            20                  25                  30          


Glu Asn Ser Arg Pro Arg Arg Ser Cys Thr Leu Glu Gly Gly Ala Lys 
        35                  40                  45              


Asn Tyr Ala Glu Ser Asp His Ser Glu Asp Glu Asp Asn Asp Asn Asn 
    50                  55                  60                  


Ser Ala Thr Ala Glu Glu Ser Thr Lys Lys Asn Lys Lys Lys Pro Pro 
65                  70                  75                  80  


Lys Lys Lys Ser Arg Tyr Glu Arg Thr Asp Thr Gly Glu Ile Thr Ser 
                85                  90                  95      


Tyr Ile Thr Glu Asp Asp Val Val Tyr Arg Pro Gly Asp Cys Val Tyr 
            100                 105                 110         


Ile Glu Ser Arg Arg Pro Asn Thr Pro Tyr Phe Ile Cys Ser Ile Gln 
        115                 120                 125             


Asp Phe Lys Leu Val His Asn Ser Gln Ala Cys Cys Arg Ser Pro Thr 
    130                 135                 140                 


Pro Ala Leu Cys Asp Pro Pro Ala Cys Ser Leu Pro Val Ala Ser Gln 
145                 150                 155                 160 


Pro Pro Gln His Leu Ser Glu Ala Gly Arg Gly Pro Val Gly Ser Lys 
                165                 170                 175     


Arg Asp His Leu Leu Met Asn Val Lys Trp Tyr Tyr Arg Gln Ser Glu 
            180                 185                 190         


Val Pro Asp Ser Val Tyr Gln His Leu Val Gln Asp Arg His Asn Glu 
        195                 200                 205             


Asn Asp Ser Gly Arg Glu Leu Val Ile Thr Asp Pro Val Ile Lys Asn 
    210                 215                 220                 


Arg Glu Leu Phe Ile Ser Asp Tyr Val Asp Thr Tyr His Ala Ala Ala 
225                 230                 235                 240 


Leu Arg Gly Lys Cys Asn Ile Ser His Phe Ser Asp Ile Phe Ala Ala 
                245                 250                 255     


Arg Glu Phe Lys Ala Arg Val Asp Ser Phe Phe Tyr Ile Leu Gly Tyr 
            260                 265                 270         


Asn Pro Glu Thr Arg Arg Leu Asn Ser Thr Gln Gly Glu Ile Arg Val 
        275                 280                 285             


Gly Pro Ser His Gln Ala Lys Leu Pro Asp Leu Gln Pro Phe Pro Ser 
    290                 295                 300                 


Pro Asp Gly Asp Thr Val Thr Gln His Glu Glu Leu Val Trp Met Pro 
305                 310                 315                 320 


Gly Val Asn Asp Cys Asp Leu Leu Met Tyr Leu Arg Ala Ala Arg Ser 
                325                 330                 335     


Met Ala Ala Phe Ala Gly Met Cys Asp Gly Gly Ser Thr Glu Asp Gly 
            340                 345                 350         


Cys Val Ala Ala Ser Arg Asp Asp Thr Thr Leu Asn Ala Leu Asn Thr 
        355                 360                 365             


Leu His Glu Ser Gly Tyr Asp Ala Gly Lys Ala Leu Gln Arg Leu Val 
    370                 375                 380                 


Lys Lys Pro Val Pro Lys Leu Ile Glu Lys Cys Trp Thr Glu Asp Glu 
385                 390                 395                 400 


Val Lys Arg Phe Val Lys Gly Leu Arg Gln Tyr Gly Lys Asn Phe Phe 
                405                 410                 415     


Arg Ile Arg Lys Glu Leu Leu Pro Asn Lys Glu Thr Gly Glu Leu Ile 
            420                 425                 430         


Thr Phe Tyr Tyr Tyr Trp Lys Lys Thr Pro Glu Ala Ala Ser Ser Arg 
        435                 440                 445             


Ala His Arg Arg His Arg Arg Gln Ala Val Phe Arg Arg Ile Lys Thr 
    450                 455                 460                 


Arg Thr Ala Ser Thr Pro Val Asn Thr Pro Ser Arg Pro Pro Ser Ser 
465                 470                 475                 480 


Glu Phe Leu Asp Leu Ser Ser Ala Ser Glu Asp Asp Phe Asp Ser Glu 
                485                 490                 495     


Asp Ser Glu Gln Glu Leu Lys Gly Tyr Ala Cys Arg His Cys Phe Thr 
            500                 505                 510         


Thr Thr Ser Lys Asp Trp His His Gly Gly Arg Glu Asn Ile Leu Leu 
        515                 520                 525             


Cys Thr Asp Cys Arg Ile His Phe Lys Lys Tyr Gly Glu Leu Pro Pro 
    530                 535                 540                 


Ile Glu Lys Pro Val Asp Pro Pro Pro Phe Met Phe Lys Pro Val Lys 
545                 550                 555                 560 


Glu Glu Asp Asp Gly Leu Ser Gly Lys His Ser Met Arg Thr Arg Arg 
                565                 570                 575     


Ser Arg Gly Ser Met Ser Thr Leu Arg Ser Gly Arg Lys Lys Gln Pro 
            580                 585                 590         


Ala Ser Pro Asp Gly Arg Thr Ser Pro Ile Asn Glu Asp Ile Arg Ser 
        595                 600                 605             


Ser Gly Arg Asn Ser Pro Ser Ala Ala Ser Thr Ser Ser Asn Asp Ser 
    610                 615                 620                 


Lys Ala Glu Thr Val Lys Lys Ser Ala Lys Lys Val Lys Glu Glu Ala 
625                 630                 635                 640 


Ser Ser Pro Leu Lys Ser Asn Lys Arg Gln Arg Glu Lys Val Ala Ser 
                645                 650                 655     


Asp Thr Glu Glu Ala Asp Arg Thr Ser Ser Lys Lys Thr Lys Thr Gln 
            660                 665                 670         


Glu Ile Ser Arg Pro Asn Ser Pro Ser Glu Gly Glu Gly Glu Ser Ser 
        675                 680                 685             


Asp Ser Arg Ser Val Asn Asp Glu Gly Ser Ser Asp Pro Lys Asp Ile 
    690                 695                 700                 


Asp Gln Asp Asn Arg Ser Thr Ser Pro Ser Ile Pro Ser Pro Gln Asp 
705                 710                 715                 720 


Asn Glu Ser Asp Ser Asp Ser Ser Ala Gln Gln Gln Met Leu Gln Ala 
                725                 730                 735     


Gln Pro Pro Ala Leu Gln Ala Pro Thr Gly Val Thr Pro Ala Pro Ser 
            740                 745                 750         


Ser Ala Pro Pro Gly Thr Pro Gln Leu Pro Thr Pro Gly Pro Thr Pro 
        755                 760                 765             


Ser Ala Thr Ala Val Pro Pro Gln Gly Ser Pro Thr Ala Ser Gln Ala 
    770                 775                 780                 


Pro Asn Gln Pro Gln Ala Pro Thr Ala Pro Val Pro His Thr His Ile 
785                 790                 795                 800 


Gln Gln Ala Pro Ala Leu His Pro Gln Arg Pro Pro Ser Pro His Pro 
                805                 810                 815     


Pro Pro His Pro Ser Pro His Pro Pro Leu Gln Pro Leu Thr Gly Ser 
            820                 825                 830         


Ala Gly Gln Pro Ser Ala Pro Ser His Ala Gln Pro Pro Leu His Gly 
        835                 840                 845             


Gln Gly Pro Pro Gly Pro His Ser Leu Gln Ala Gly Pro Leu Leu Gln 
    850                 855                 860                 


His Pro Gly Pro Pro Gln Pro Phe Gly Leu Pro Pro Gln Ala Ser Gln 
865                 870                 875                 880 


Gly Gln Ala Pro Leu Gly Thr Ser Pro Ala Ala Ala Tyr Pro His Thr 
                885                 890                 895     


Ser Leu Gln Leu Pro Ala Ser Gln Ser Ala Leu Gln Ser Gln Gln Pro 
            900                 905                 910         


Pro Arg Glu Gln Pro Leu Pro Pro Ala Pro Leu Ala Met Pro His Ile 
        915                 920                 925             


Lys Pro Pro Pro Thr Thr Pro Ile Pro Gln Leu Pro Ala Pro Gln Ala 
    930                 935                 940                 


His Lys His Pro Pro His Leu Ser Gly Pro Ser Pro Phe Ser Met Asn 
945                 950                 955                 960 


Ala Asn Leu Pro Pro Pro Pro Ala Leu Lys Pro Leu Ser Ser Leu Ser 
                965                 970                 975     


Thr His His Pro Pro Ser Ala His Pro Pro Pro Leu Gln Leu Met Pro 
            980                 985                 990         


Gln Ser Gln Pro Leu Pro Ser Ser  Pro Ala Gln Pro Pro  Gly Leu Thr 
        995                 1000                 1005             


Gln Ser  Gln Asn Leu Pro Pro  Pro Pro Ala Ser His  Pro Pro Thr 
    1010                 1015                 1020             


Gly Leu  His Gln Val Ala Pro  Gln Pro Pro Phe Ala  Gln His Pro 
    1025                 1030                 1035             


Phe Val  Pro Gly Gly Pro Pro  Pro Ile Thr Pro Pro  Thr Cys Pro 
    1040                 1045                 1050             


Ser Thr  Ser Thr Pro Pro Ala  Gly Pro Gly Thr Ser  Ala Gln Pro 
    1055                 1060                 1065             


Pro Cys  Ser Gly Ala Ala Ala  Ser Gly Gly Ser Ile  Ala Gly Gly 
    1070                 1075                 1080             


Ser Ser  Cys Pro Leu Pro Thr  Val Gln Ile Lys Glu  Glu Ala Leu 
    1085                 1090                 1095             


Asp Asp  Ala Glu Glu Pro Glu  Ser Pro Pro Pro Pro  Pro Arg Ser 
    1100                 1105                 1110             


Pro Ser  Pro Glu Pro Thr Val  Val Asp Thr Pro Ser  His Ala Ser 
    1115                 1120                 1125             


Gln Ser  Ala Arg Phe Tyr Lys  His Leu Asp Arg Gly  Tyr Asn Ser 
    1130                 1135                 1140             


Cys Ala  Arg Thr Asp Leu Tyr  Phe Met Pro Leu Ala  Gly Ser Lys 
    1145                 1150                 1155             


Leu Ala  Lys Lys Arg Glu Glu  Ala Ile Glu Lys Ala  Lys Arg Glu 
    1160                 1165                 1170             


Ala Glu  Gln Lys Ala Arg Glu  Glu Arg Glu Arg Glu  Lys Glu Lys 
    1175                 1180                 1185             


Glu Lys  Glu Arg Glu Arg Glu  Arg Glu Arg Glu Arg  Glu Ala Glu 
    1190                 1195                 1200             


Arg Ala  Ala Lys Ala Ser Ser  Ser Ala His Glu Gly  Arg Leu Ser 
    1205                 1210                 1215             


Asp Pro  Gln Leu Ser Gly Pro  Gly His Met Arg Pro  Ser Phe Glu 
    1220                 1225                 1230             


Pro Pro  Pro Thr Thr Ile Ala  Ala Val Pro Pro Tyr  Ile Gly Pro 
    1235                 1240                 1245             


Asp Thr  Pro Ala Leu Arg Thr  Leu Ser Glu Tyr Ala  Arg Pro His 
    1250                 1255                 1260             


Val Met  Ser Pro Thr Asn Arg  Asn His Pro Phe Tyr  Met Pro Leu 
    1265                 1270                 1275             


Asn Pro  Thr Asp Pro Leu Leu  Ala Tyr His Met Pro  Gly Leu Tyr 
    1280                 1285                 1290             


Asn Val  Asp Pro Thr Ile Arg  Glu Arg Glu Leu Arg  Glu Arg Glu 
    1295                 1300                 1305             


Ile Arg  Glu Arg Glu Ile Arg  Glu Arg Glu Leu Arg  Glu Arg Met 
    1310                 1315                 1320             


Lys Pro  Gly Phe Glu Val Lys  Pro Pro Glu Leu Asp  Pro Leu His 
    1325                 1330                 1335             


Pro Ala  Ala Asn Pro Met Glu  His Phe Ala Arg His  Ser Ala Leu 
    1340                 1345                 1350             


Thr Ile  Pro Pro Thr Ala Gly  Pro His Pro Phe Ala  Ser Phe His 
    1355                 1360                 1365             


Pro Gly  Leu Asn Pro Leu Glu  Arg Glu Arg Leu Ala  Leu Ala Gly 
    1370                 1375                 1380             


Pro Gln  Leu Arg Pro Glu Met  Ser Tyr Pro Asp Arg  Leu Ala Ala 
    1385                 1390                 1395             


Glu Arg  Ile His Ala Glu Arg  Met Ala Ser Leu Thr  Ser Asp Pro 
    1400                 1405                 1410             


Leu Ala  Arg Leu Gln Met Phe  Asn Val Thr Pro His  His His Gln 
    1415                 1420                 1425             


His Ser  His Ile His Ser His  Leu His Leu His Gln  Gln Asp Pro 
    1430                 1435                 1440             


Leu His  Gln Gly Ser Ala Gly  Pro Val His Pro Leu  Val Asp Pro 
    1445                 1450                 1455             


Leu Thr  Ala Gly Pro His Leu  Ala Arg Phe Pro Tyr  Pro Pro Gly 
    1460                 1465                 1470             


Thr Leu  Pro Asn Pro Leu Leu  Gly Gln Pro Pro His  Glu His Glu 
    1475                 1480                 1485             


Met Leu  Arg His Pro Val Phe  Gly Thr Pro Tyr Pro  Arg Asp Leu 
    1490                 1495                 1500             


Pro Gly  Ala Ile Pro Pro Pro  Met Ser Ala Ala His  Gln Leu Gln 
    1505                 1510                 1515             


Ala Met  His Ala Gln Ser Ala  Glu Leu Gln Arg Leu  Ala Met Glu 
    1520                 1525                 1530             


Gln Gln  Trp Leu His Gly His  Pro His Met His Gly  Gly His Leu 
    1535                 1540                 1545             


Pro Ser  Gln Glu Asp Tyr Tyr  Ser Arg Leu Lys Lys  Glu Gly Asp 
    1550                 1555                 1560             


Lys Gln  Leu 
    1565     


<210> 223
<211> 960
<212> PRT
<213> Homo sapiens

<400> 223
Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
            900                 905                 910         


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
        915                 920                 925             


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
    930                 935                 940                 


Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 960 


<210> 224
<211> 486
<212> PRT
<213> Homo sapiens

<400> 224
Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Ser Glu Asp Gln 
1               5                   10                  15      


Asp Leu Gln Gly Leu Lys Asp Lys Pro Leu Lys Phe Lys Lys Val Lys 
            20                  25                  30          


Lys Asp Lys Lys Glu Glu Lys Glu Gly Lys His Glu Pro Val Gln Pro 
        35                  40                  45              


Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu Thr 
    50                  55                  60                  


Ser Glu Gly Ser Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala Ser 
65                  70                  75                  80  


Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr Asp 
                85                  90                  95      


Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys 
            100                 105                 110         


Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln 
        115                 120                 125             


Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu Lys 
    130                 135                 140                 


Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val Thr 
145                 150                 155                 160 


Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys Pro 
                165                 170                 175     


Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro Lys 
            180                 185                 190         


Gly Ser Gly Thr Thr Arg Pro Lys Ala Ala Thr Ser Glu Gly Val Gln 
        195                 200                 205             


Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Leu Val Lys Met 
    210                 215                 220                 


Pro Phe Gln Thr Ser Pro Gly Gly Lys Ala Glu Gly Gly Gly Ala Thr 
225                 230                 235                 240 


Thr Ser Thr Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg Lys 
                245                 250                 255     


Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys Pro 
            260                 265                 270         


Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val 
        275                 280                 285             


Lys Glu Ser Ser Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile Lys 
    290                 295                 300                 


Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val Val 
305                 310                 315                 320 


Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly Leu 
                325                 330                 335     


Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro Lys 
            340                 345                 350         


Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His His 
        355                 360                 365             


His His His His Ser Glu Ser Pro Lys Ala Pro Val Pro Leu Leu Pro 
    370                 375                 380                 


Pro Leu Pro Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Thr 
385                 390                 395                 400 


Ser Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Val Cys Lys Glu Glu 
                405                 410                 415     


Lys Met Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu 
            420                 425                 430         


Pro Ala Lys Thr Gln Pro Ala Val Ala Thr Ala Ala Thr Ala Ala Glu 
        435                 440                 445             


Lys Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser 
    450                 455                 460                 


Ser Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro 
465                 470                 475                 480 


Val Thr Glu Arg Val Ser 
                485     


<210> 225
<211> 5537
<212> PRT
<213> Homo sapiens

<400> 225
Met Asp Ser Gln Lys Leu Ala Gly Glu Asp Lys Asp Ser Glu Pro Ala 
1               5                   10                  15      


Ala Asp Gly Pro Ala Ala Ser Glu Asp Pro Ser Ala Thr Glu Ser Asp 
            20                  25                  30          


Leu Pro Asn Pro His Val Gly Glu Val Ser Val Leu Ser Ser Gly Ser 
        35                  40                  45              


Pro Arg Leu Gln Glu Thr Pro Gln Asp Cys Ser Gly Gly Pro Val Arg 
    50                  55                  60                  


Arg Cys Ala Leu Cys Asn Cys Gly Glu Pro Ser Leu His Gly Gln Arg 
65                  70                  75                  80  


Glu Leu Arg Arg Phe Glu Leu Pro Phe Asp Trp Pro Arg Cys Pro Val 
                85                  90                  95      


Val Ser Pro Gly Gly Ser Pro Gly Pro Asn Glu Ala Val Leu Pro Ser 
            100                 105                 110         


Glu Asp Leu Ser Gln Ile Gly Phe Pro Glu Gly Leu Thr Pro Ala His 
        115                 120                 125             


Leu Gly Glu Pro Gly Gly Ser Cys Trp Ala His His Trp Cys Ala Ala 
    130                 135                 140                 


Trp Ser Ala Gly Val Trp Gly Gln Glu Gly Pro Glu Leu Cys Gly Val 
145                 150                 155                 160 


Asp Lys Ala Ile Phe Ser Gly Ile Ser Gln Arg Cys Ser His Cys Thr 
                165                 170                 175     


Arg Leu Gly Ala Ser Ile Pro Cys Arg Ser Pro Gly Cys Pro Arg Leu 
            180                 185                 190         


Tyr His Phe Pro Cys Ala Thr Ala Ser Gly Ser Phe Leu Ser Met Lys 
        195                 200                 205             


Thr Leu Gln Leu Leu Cys Pro Glu His Ser Glu Gly Ala Ala Tyr Leu 
    210                 215                 220                 


Glu Glu Ala Arg Cys Ala Val Cys Glu Gly Pro Gly Glu Leu Cys Asp 
225                 230                 235                 240 


Leu Phe Phe Cys Thr Ser Cys Gly His His Tyr His Gly Ala Cys Leu 
                245                 250                 255     


Asp Thr Ala Leu Thr Ala Arg Lys Arg Ala Gly Trp Gln Cys Pro Glu 
            260                 265                 270         


Cys Lys Val Cys Gln Ala Cys Arg Lys Pro Gly Asn Asp Ser Lys Met 
        275                 280                 285             


Leu Val Cys Glu Thr Cys Asp Lys Gly Tyr His Thr Phe Cys Leu Lys 
    290                 295                 300                 


Pro Pro Met Glu Glu Leu Pro Ala His Ser Trp Lys Cys Lys Ala Cys 
305                 310                 315                 320 


Arg Val Cys Arg Ala Cys Gly Ala Gly Ser Ala Glu Leu Asn Pro Asn 
                325                 330                 335     


Ser Glu Trp Phe Glu Asn Tyr Ser Leu Cys His Arg Cys His Lys Ala 
            340                 345                 350         


Gln Gly Gly Gln Thr Ile Arg Ser Val Ala Glu Gln His Thr Pro Val 
        355                 360                 365             


Cys Ser Arg Phe Ser Pro Pro Glu Pro Gly Asp Thr Pro Thr Asp Glu 
    370                 375                 380                 


Pro Asp Ala Leu Tyr Val Ala Cys Gln Gly Gln Pro Lys Gly Gly His 
385                 390                 395                 400 


Val Thr Ser Met Gln Pro Lys Glu Pro Gly Pro Leu Gln Cys Glu Ala 
                405                 410                 415     


Lys Pro Leu Gly Lys Ala Gly Val Gln Leu Glu Pro Gln Leu Glu Ala 
            420                 425                 430         


Pro Leu Asn Glu Glu Met Pro Leu Leu Pro Pro Pro Glu Glu Ser Pro 
        435                 440                 445             


Leu Ser Pro Pro Pro Glu Glu Ser Pro Thr Ser Pro Pro Pro Glu Ala 
    450                 455                 460                 


Ser Arg Leu Ser Pro Pro Pro Glu Glu Leu Pro Ala Ser Pro Leu Pro 
465                 470                 475                 480 


Glu Ala Leu His Leu Ser Arg Pro Leu Glu Glu Ser Pro Leu Ser Pro 
                485                 490                 495     


Pro Pro Glu Glu Ser Pro Leu Ser Pro Pro Pro Glu Ser Ser Pro Phe 
            500                 505                 510         


Ser Pro Leu Glu Glu Ser Pro Leu Ser Pro Pro Glu Glu Ser Pro Pro 
        515                 520                 525             


Ser Pro Ala Leu Glu Thr Pro Leu Ser Pro Pro Pro Glu Ala Ser Pro 
    530                 535                 540                 


Leu Ser Pro Pro Phe Glu Glu Ser Pro Leu Ser Pro Pro Pro Glu Glu 
545                 550                 555                 560 


Leu Pro Thr Ser Pro Pro Pro Glu Ala Ser Arg Leu Ser Pro Pro Pro 
                565                 570                 575     


Glu Glu Ser Pro Met Ser Pro Pro Pro Glu Glu Ser Pro Met Ser Pro 
            580                 585                 590         


Pro Pro Glu Ala Ser Arg Leu Phe Pro Pro Phe Glu Glu Ser Pro Leu 
        595                 600                 605             


Ser Pro Pro Pro Glu Glu Ser Pro Leu Ser Pro Pro Pro Glu Ala Ser 
    610                 615                 620                 


Arg Leu Ser Pro Pro Pro Glu Asp Ser Pro Met Ser Pro Pro Pro Glu 
625                 630                 635                 640 


Glu Ser Pro Met Ser Pro Pro Pro Glu Val Ser Arg Leu Ser Pro Leu 
                645                 650                 655     


Pro Val Val Ser Arg Leu Ser Pro Pro Pro Glu Glu Ser Pro Leu Ser 
            660                 665                 670         


Pro Pro Pro Glu Glu Ser Pro Thr Ser Pro Pro Pro Glu Ala Ser Arg 
        675                 680                 685             


Leu Ser Pro Pro Pro Glu Asp Ser Pro Thr Ser Pro Pro Pro Glu Asp 
    690                 695                 700                 


Ser Pro Ala Ser Pro Pro Pro Glu Asp Ser Leu Met Ser Leu Pro Leu 
705                 710                 715                 720 


Glu Glu Ser Pro Leu Leu Pro Leu Pro Glu Glu Pro Gln Leu Cys Pro 
                725                 730                 735     


Arg Ser Glu Gly Pro His Leu Ser Pro Arg Pro Glu Glu Pro His Leu 
            740                 745                 750         


Ser Pro Arg Pro Glu Glu Pro His Leu Ser Pro Gln Ala Glu Glu Pro 
        755                 760                 765             


His Leu Ser Pro Gln Pro Glu Glu Pro Cys Leu Cys Ala Val Pro Glu 
    770                 775                 780                 


Glu Pro His Leu Ser Pro Gln Ala Glu Gly Pro His Leu Ser Pro Gln 
785                 790                 795                 800 


Pro Glu Glu Leu His Leu Ser Pro Gln Thr Glu Glu Pro His Leu Ser 
                805                 810                 815     


Pro Val Pro Glu Glu Pro Cys Leu Ser Pro Gln Pro Glu Glu Ser His 
            820                 825                 830         


Leu Ser Pro Gln Ser Glu Glu Pro Cys Leu Ser Pro Arg Pro Glu Glu 
        835                 840                 845             


Ser His Leu Ser Pro Glu Leu Glu Lys Pro Pro Leu Ser Pro Arg Pro 
    850                 855                 860                 


Glu Lys Pro Pro Glu Glu Pro Gly Gln Cys Pro Ala Pro Glu Glu Leu 
865                 870                 875                 880 


Pro Leu Phe Pro Pro Pro Gly Glu Pro Ser Leu Ser Pro Leu Leu Gly 
                885                 890                 895     


Glu Pro Ala Leu Ser Glu Pro Gly Glu Pro Pro Leu Ser Pro Leu Pro 
            900                 905                 910         


Glu Glu Leu Pro Leu Ser Pro Ser Gly Glu Pro Ser Leu Ser Pro Gln 
        915                 920                 925             


Leu Met Pro Pro Asp Pro Leu Pro Pro Pro Leu Ser Pro Ile Ile Thr 
    930                 935                 940                 


Ala Ala Ala Pro Pro Ala Leu Ser Pro Leu Gly Glu Leu Glu Tyr Pro 
945                 950                 955                 960 


Phe Gly Ala Lys Gly Asp Ser Asp Pro Glu Ser Pro Leu Ala Ala Pro 
                965                 970                 975     


Ile Leu Glu Thr Pro Ile Ser Pro Pro Pro Glu Ala Asn Cys Thr Asp 
            980                 985                 990         


Pro Glu Pro Val Pro Pro Met Ile  Leu Pro Pro Ser Pro  Gly Ser Pro 
        995                 1000                 1005             


Val Gly  Pro Ala Ser Pro Ile  Leu Met Glu Pro Leu  Pro Pro Gln 
    1010                 1015                 1020             


Cys Ser  Pro Leu Leu Gln His  Ser Leu Val Pro Gln  Asn Ser Pro 
    1025                 1030                 1035             


Pro Ser  Gln Cys Ser Pro Pro  Ala Leu Pro Leu Ser  Val Pro Ser 
    1040                 1045                 1050             


Pro Leu  Ser Pro Ile Gly Lys  Val Val Gly Val Ser  Asp Glu Ala 
    1055                 1060                 1065             


Glu Leu  His Glu Met Glu Thr  Glu Lys Val Ser Glu  Pro Glu Cys 
    1070                 1075                 1080             


Pro Ala  Leu Glu Pro Ser Ala  Thr Ser Pro Leu Pro  Ser Pro Met 
    1085                 1090                 1095             


Gly Asp  Leu Ser Cys Pro Ala  Pro Ser Pro Ala Pro  Ala Leu Asp 
    1100                 1105                 1110             


Asp Phe  Ser Gly Leu Gly Glu  Asp Thr Ala Pro Leu  Asp Gly Ile 
    1115                 1120                 1125             


Asp Ala  Pro Gly Ser Gln Pro  Glu Pro Gly Gln Thr  Pro Gly Ser 
    1130                 1135                 1140             


Leu Ala  Ser Glu Leu Lys Gly  Ser Pro Val Leu Leu  Asp Pro Glu 
    1145                 1150                 1155             


Glu Leu  Ala Pro Val Thr Pro  Met Glu Val Tyr Pro  Glu Cys Lys 
    1160                 1165                 1170             


Gln Thr  Ala Gly Gln Gly Ser  Pro Cys Glu Glu Gln  Glu Glu Pro 
    1175                 1180                 1185             


Arg Ala  Pro Val Ala Pro Thr  Pro Pro Thr Leu Ile  Lys Ser Asp 
    1190                 1195                 1200             


Ile Val  Asn Glu Ile Ser Asn  Leu Ser Gln Gly Asp  Ala Ser Ala 
    1205                 1210                 1215             


Ser Phe  Pro Gly Ser Glu Pro  Leu Leu Gly Ser Pro  Asp Pro Glu 
    1220                 1225                 1230             


Gly Gly  Gly Ser Leu Ser Met  Glu Leu Gly Val Ser  Thr Asp Val 
    1235                 1240                 1245             


Ser Pro  Ala Arg Asp Glu Gly  Ser Leu Arg Leu Cys  Thr Asp Ser 
    1250                 1255                 1260             


Leu Pro  Glu Thr Asp Asp Ser  Leu Leu Cys Asp Ala  Gly Thr Ala 
    1265                 1270                 1275             


Ile Ser  Gly Gly Lys Ala Glu  Gly Glu Lys Gly Arg  Arg Arg Ser 
    1280                 1285                 1290             


Ser Pro  Ala Arg Ser Arg Ile  Lys Gln Gly Arg Ser  Ser Ser Phe 
    1295                 1300                 1305             


Pro Gly  Arg Arg Arg Pro Arg  Gly Gly Ala His Gly  Gly Arg Gly 
    1310                 1315                 1320             


Arg Gly  Arg Ala Arg Leu Lys  Ser Thr Ala Ser Ser  Ile Glu Thr 
    1325                 1330                 1335             


Leu Val  Val Ala Asp Ile Asp  Ser Ser Pro Ser Lys  Glu Glu Glu 
    1340                 1345                 1350             


Glu Glu  Asp Asp Asp Thr Met  Gln Asn Thr Val Val  Leu Phe Ser 
    1355                 1360                 1365             


Asn Thr  Asp Lys Phe Val Leu  Met Gln Asp Met Cys  Val Val Cys 
    1370                 1375                 1380             


Gly Ser  Phe Gly Arg Gly Ala  Glu Gly His Leu Leu  Ala Cys Ser 
    1385                 1390                 1395             


Gln Cys  Ser Gln Cys Tyr His  Pro Tyr Cys Val Asn  Ser Lys Ile 
    1400                 1405                 1410             


Thr Lys  Val Met Leu Leu Lys  Gly Trp Arg Cys Val  Glu Cys Ile 
    1415                 1420                 1425             


Val Cys  Glu Val Cys Gly Gln  Ala Ser Asp Pro Ser  Arg Leu Leu 
    1430                 1435                 1440             


Leu Cys  Asp Asp Cys Asp Ile  Ser Tyr His Thr Tyr  Cys Leu Asp 
    1445                 1450                 1455             


Pro Pro  Leu Leu Thr Val Pro  Lys Gly Gly Trp Lys  Cys Lys Trp 
    1460                 1465                 1470             


Cys Val  Ser Cys Met Gln Cys  Gly Ala Ala Ser Pro  Gly Phe His 
    1475                 1480                 1485             


Cys Glu  Trp Gln Asn Ser Tyr  Thr His Cys Gly Pro  Cys Ala Ser 
    1490                 1495                 1500             


Leu Val  Thr Cys Pro Ile Cys  His Ala Pro Tyr Val  Glu Glu Asp 
    1505                 1510                 1515             


Leu Leu  Ile Gln Cys Arg His  Cys Glu Arg Trp Met  His Ala Gly 
    1520                 1525                 1530             


Cys Glu  Ser Leu Phe Thr Glu  Asp Asp Val Glu Gln  Ala Ala Asp 
    1535                 1540                 1545             


Glu Gly  Phe Asp Cys Val Ser  Cys Gln Pro Tyr Val  Val Lys Pro 
    1550                 1555                 1560             


Val Ala  Pro Val Ala Pro Pro  Glu Leu Val Pro Met  Lys Val Lys 
    1565                 1570                 1575             


Glu Pro  Glu Pro Gln Tyr Phe  Arg Phe Glu Gly Val  Trp Leu Thr 
    1580                 1585                 1590             


Glu Thr  Gly Met Ala Leu Leu  Arg Asn Leu Thr Met  Ser Pro Leu 
    1595                 1600                 1605             


His Lys  Arg Arg Gln Arg Arg  Gly Arg Leu Gly Leu  Pro Gly Glu 
    1610                 1615                 1620             


Ala Gly  Leu Glu Gly Ser Glu  Pro Ser Asp Ala Leu  Gly Pro Asp 
    1625                 1630                 1635             


Asp Lys  Lys Asp Gly Asp Leu  Asp Thr Asp Glu Leu  Leu Lys Gly 
    1640                 1645                 1650             


Glu Gly  Gly Val Glu His Met  Glu Cys Glu Ile Lys  Leu Glu Gly 
    1655                 1660                 1665             


Pro Val  Ser Pro Asp Val Glu  Pro Gly Lys Glu Glu  Thr Glu Glu 
    1670                 1675                 1680             


Ser Lys  Lys Arg Lys Arg Lys  Pro Tyr Arg Pro Gly  Ile Gly Gly 
    1685                 1690                 1695             


Phe Met  Val Arg Gln Arg Lys  Ser His Thr Arg Thr  Lys Lys Gly 
    1700                 1705                 1710             


Pro Ala  Ala Gln Ala Glu Val  Leu Ser Gly Asp Gly  Gln Pro Asp 
    1715                 1720                 1725             


Glu Val  Ile Pro Ala Asp Leu  Pro Ala Glu Gly Ala  Val Glu Gln 
    1730                 1735                 1740             


Ser Leu  Ala Glu Gly Asp Glu  Lys Lys Lys Gln Gln  Arg Arg Gly 
    1745                 1750                 1755             


Arg Lys  Lys Ser Lys Leu Glu  Asp Met Phe Pro Ala  Tyr Leu Gln 
    1760                 1765                 1770             


Glu Ala  Phe Phe Gly Lys Glu  Leu Leu Asp Leu Ser  Arg Lys Ala 
    1775                 1780                 1785             


Leu Phe  Ala Val Gly Val Gly  Arg Pro Ser Phe Gly  Leu Gly Thr 
    1790                 1795                 1800             


Pro Lys  Ala Lys Gly Asp Gly  Gly Ser Glu Arg Lys  Glu Leu Pro 
    1805                 1810                 1815             


Thr Ser  Gln Lys Gly Asp Asp  Gly Pro Asp Ile Ala  Asp Glu Glu 
    1820                 1825                 1830             


Ser Arg  Gly Leu Glu Gly Lys  Ala Asp Thr Pro Gly  Pro Glu Asp 
    1835                 1840                 1845             


Gly Gly  Val Lys Ala Ser Pro  Val Pro Ser Asp Pro  Glu Lys Pro 
    1850                 1855                 1860             


Gly Thr  Pro Gly Glu Gly Met  Leu Ser Ser Asp Leu  Asp Arg Ile 
    1865                 1870                 1875             


Ser Thr  Glu Glu Leu Pro Lys  Met Glu Ser Lys Asp  Leu Gln Gln 
    1880                 1885                 1890             


Leu Phe  Lys Asp Val Leu Gly  Ser Glu Arg Glu Gln  His Leu Gly 
    1895                 1900                 1905             


Cys Gly  Thr Pro Gly Leu Glu  Gly Ser Arg Thr Pro  Leu Gln Arg 
    1910                 1915                 1920             


Pro Phe  Leu Gln Gly Gly Leu  Pro Leu Gly Asn Leu  Pro Ser Ser 
    1925                 1930                 1935             


Ser Pro  Met Asp Ser Tyr Pro  Gly Leu Cys Gln Ser  Pro Phe Leu 
    1940                 1945                 1950             


Asp Ser  Arg Glu Arg Gly Gly  Phe Phe Ser Pro Glu  Pro Gly Glu 
    1955                 1960                 1965             


Pro Asp  Ser Pro Trp Thr Gly  Ser Gly Gly Thr Thr  Pro Ser Thr 
    1970                 1975                 1980             


Pro Thr  Thr Pro Thr Thr Glu  Gly Glu Gly Asp Gly  Leu Ser Tyr 
    1985                 1990                 1995             


Asn Gln  Arg Ser Leu Gln Arg  Trp Glu Lys Asp Glu  Glu Leu Gly 
    2000                 2005                 2010             


Gln Leu  Ser Thr Ile Ser Pro  Val Leu Tyr Ala Asn  Ile Asn Phe 
    2015                 2020                 2025             


Pro Asn  Leu Lys Gln Asp Tyr  Pro Asp Trp Ser Ser  Arg Cys Lys 
    2030                 2035                 2040             


Gln Ile  Met Lys Leu Trp Arg  Lys Val Pro Ala Ala  Asp Lys Ala 
    2045                 2050                 2055             


Pro Tyr  Leu Gln Lys Ala Lys  Asp Asn Arg Ala Ala  His Arg Ile 
    2060                 2065                 2070             


Asn Lys  Val Gln Lys Gln Ala  Glu Ser Gln Ile Asn  Lys Gln Thr 
    2075                 2080                 2085             


Lys Val  Gly Asp Ile Ala Arg  Lys Thr Asp Arg Pro  Ala Leu His 
    2090                 2095                 2100             


Leu Arg  Ile Pro Pro Gln Pro  Gly Ala Leu Gly Ser  Pro Pro Pro 
    2105                 2110                 2115             


Ala Ala  Ala Pro Thr Ile Phe  Ile Gly Ser Pro Thr  Thr Pro Ala 
    2120                 2125                 2130             


Gly Leu  Ser Thr Ser Ala Asp  Gly Phe Leu Lys Pro  Pro Ala Gly 
    2135                 2140                 2145             


Ser Val  Pro Gly Pro Asp Ser  Pro Gly Glu Leu Phe  Leu Lys Leu 
    2150                 2155                 2160             


Pro Pro  Gln Val Pro Ala Gln  Val Pro Ser Gln Asp  Pro Phe Gly 
    2165                 2170                 2175             


Leu Ala  Pro Ala Tyr Pro Leu  Glu Pro Arg Phe Pro  Thr Ala Pro 
    2180                 2185                 2190             


Pro Thr  Tyr Pro Pro Tyr Pro  Ser Pro Thr Gly Ala  Pro Ala Gln 
    2195                 2200                 2205             


Pro Pro  Met Leu Gly Ala Ser  Ser Arg Pro Gly Ala  Gly Gln Pro 
    2210                 2215                 2220             


Gly Glu  Phe His Thr Thr Pro  Pro Gly Thr Pro Arg  His Gln Pro 
    2225                 2230                 2235             


Ser Thr  Pro Asp Pro Phe Leu  Lys Pro Arg Cys Pro  Ser Leu Asp 
    2240                 2245                 2250             


Asn Leu  Ala Val Pro Glu Ser  Pro Gly Val Gly Gly  Gly Lys Ala 
    2255                 2260                 2265             


Ser Glu  Pro Leu Leu Ser Pro  Pro Pro Phe Gly Glu  Ser Arg Lys 
    2270                 2275                 2280             


Ala Leu  Glu Val Lys Lys Glu  Glu Leu Gly Ala Ser  Ser Pro Ser 
    2285                 2290                 2295             


Tyr Gly  Pro Pro Asn Leu Gly  Phe Val Asp Ser Pro  Ser Ser Gly 
    2300                 2305                 2310             


Thr His  Leu Gly Gly Leu Glu  Leu Lys Thr Pro Asp  Val Phe Lys 
    2315                 2320                 2325             


Ala Pro  Leu Thr Pro Arg Ala  Ser Gln Val Glu Pro  Gln Ser Pro 
    2330                 2335                 2340             


Gly Leu  Gly Leu Arg Pro Gln  Glu Pro Pro Pro Ala  Gln Ala Leu 
    2345                 2350                 2355             


Ala Pro  Ser Pro Pro Ser His  Pro Asp Ile Phe Arg  Pro Gly Ser 
    2360                 2365                 2370             


Tyr Thr  Asp Pro Tyr Ala Gln  Pro Pro Leu Thr Pro  Arg Pro Gln 
    2375                 2380                 2385             


Pro Pro  Pro Pro Glu Ser Cys  Cys Ala Leu Pro Pro  Arg Ser Leu 
    2390                 2395                 2400             


Pro Ser  Asp Pro Phe Ser Arg  Val Pro Ala Ser Pro  Gln Ser Gln 
    2405                 2410                 2415             


Ser Ser  Ser Gln Ser Pro Leu  Thr Pro Arg Pro Leu  Ser Ala Glu 
    2420                 2425                 2430             


Ala Phe  Cys Pro Ser Pro Val  Thr Pro Arg Phe Gln  Ser Pro Asp 
    2435                 2440                 2445             


Pro Tyr  Ser Arg Pro Pro Ser  Arg Pro Gln Ser Arg  Asp Pro Phe 
    2450                 2455                 2460             


Ala Pro  Leu His Lys Pro Pro  Arg Pro Gln Pro Pro  Glu Val Ala 
    2465                 2470                 2475             


Phe Lys  Ala Gly Ser Leu Ala  His Thr Ser Leu Gly  Ala Gly Gly 
    2480                 2485                 2490             


Phe Pro  Ala Ala Leu Pro Ala  Gly Pro Ala Gly Glu  Leu His Ala 
    2495                 2500                 2505             


Lys Val  Pro Ser Gly Gln Pro  Pro Asn Phe Val Arg  Ser Pro Gly 
    2510                 2515                 2520             


Thr Gly  Ala Phe Val Gly Thr  Pro Ser Pro Met Arg  Phe Thr Phe 
    2525                 2530                 2535             


Pro Gln  Ala Val Gly Glu Pro  Ser Leu Lys Pro Pro  Val Pro Gln 
    2540                 2545                 2550             


Pro Gly  Leu Pro Pro Pro His  Gly Ile Asn Ser His  Phe Gly Pro 
    2555                 2560                 2565             


Gly Pro  Thr Leu Gly Lys Pro  Gln Ser Thr Asn Tyr  Thr Val Ala 
    2570                 2575                 2580             


Thr Gly  Asn Phe His Pro Ser  Gly Ser Pro Leu Gly  Pro Ser Ser 
    2585                 2590                 2595             


Gly Ser  Thr Gly Glu Ser Tyr  Gly Leu Ser Pro Leu  Arg Pro Pro 
    2600                 2605                 2610             


Ser Val  Leu Pro Pro Pro Ala  Pro Asp Gly Ser Leu  Pro Tyr Leu 
    2615                 2620                 2625             


Ser His  Gly Ala Ser Gln Arg  Ser Gly Ile Thr Ser  Pro Val Glu 
    2630                 2635                 2640             


Lys Arg  Glu Asp Pro Gly Thr  Gly Met Gly Ser Ser  Leu Ala Thr 
    2645                 2650                 2655             


Ala Glu  Leu Pro Gly Thr Gln  Asp Pro Gly Met Ser  Gly Leu Ser 
    2660                 2665                 2670             


Gln Thr  Glu Leu Glu Lys Gln  Arg Gln Arg Gln Arg  Leu Arg Glu 
    2675                 2680                 2685             


Leu Leu  Ile Arg Gln Gln Ile  Gln Arg Asn Thr Leu  Arg Gln Glu 
    2690                 2695                 2700             


Lys Glu  Thr Ala Ala Ala Ala  Ala Gly Ala Val Gly  Pro Pro Gly 
    2705                 2710                 2715             


Ser Trp  Gly Ala Glu Pro Ser  Ser Pro Ala Phe Glu  Gln Leu Ser 
    2720                 2725                 2730             


Arg Gly  Gln Thr Pro Phe Ala  Gly Thr Gln Asp Lys  Ser Ser Leu 
    2735                 2740                 2745             


Val Gly  Leu Pro Pro Ser Lys  Leu Ser Gly Pro Ile  Leu Gly Pro 
    2750                 2755                 2760             


Gly Ser  Phe Pro Ser Asp Asp  Arg Leu Ser Arg Pro  Pro Pro Pro 
    2765                 2770                 2775             


Ala Thr  Pro Ser Ser Met Asp  Val Asn Ser Arg Gln  Leu Val Gly 
    2780                 2785                 2790             


Gly Ser  Gln Ala Phe Tyr Gln  Arg Ala Pro Tyr Pro  Gly Ser Leu 
    2795                 2800                 2805             


Pro Leu  Gln Gln Gln Gln Gln  Gln Leu Trp Gln Gln  Gln Gln Ala 
    2810                 2815                 2820             


Thr Ala  Ala Thr Ser Met Arg  Phe Ala Met Ser Ala  Arg Phe Pro 
    2825                 2830                 2835             


Ser Thr  Pro Gly Pro Glu Leu  Gly Arg Gln Ala Leu  Gly Ser Pro 
    2840                 2845                 2850             


Leu Ala  Gly Ile Ser Thr Arg  Leu Pro Gly Pro Gly  Glu Pro Val 
    2855                 2860                 2865             


Pro Gly  Pro Ala Gly Pro Ala  Gln Phe Ile Glu Leu  Arg His Asn 
    2870                 2875                 2880             


Val Gln  Lys Gly Leu Gly Pro  Gly Gly Thr Pro Phe  Pro Gly Gln 
    2885                 2890                 2895             


Gly Pro  Pro Gln Arg Pro Arg  Phe Tyr Pro Val Ser  Glu Asp Pro 
    2900                 2905                 2910             


His Arg  Leu Ala Pro Glu Gly  Leu Arg Gly Leu Ala  Val Ser Gly 
    2915                 2920                 2925             


Leu Pro  Pro Gln Lys Pro Ser  Ala Pro Pro Ala Pro  Glu Leu Asn 
    2930                 2935                 2940             


Asn Ser  Leu His Pro Thr Pro  His Thr Lys Gly Pro  Thr Leu Pro 
    2945                 2950                 2955             


Thr Gly  Leu Glu Leu Val Asn  Arg Pro Pro Ser Ser  Thr Glu Leu 
    2960                 2965                 2970             


Gly Arg  Pro Asn Pro Leu Ala  Leu Glu Ala Gly Lys  Leu Pro Cys 
    2975                 2980                 2985             


Glu Asp  Pro Glu Leu Asp Asp  Asp Phe Asp Ala His  Lys Ala Leu 
    2990                 2995                 3000             


Glu Asp  Asp Glu Glu Leu Ala  His Leu Gly Leu Gly  Val Asp Val 
    3005                 3010                 3015             


Ala Lys  Gly Asp Asp Glu Leu  Gly Thr Leu Glu Asn  Leu Glu Thr 
    3020                 3025                 3030             


Asn Asp  Pro His Leu Asp Asp  Leu Leu Asn Gly Asp  Glu Phe Asp 
    3035                 3040                 3045             


Leu Leu  Ala Tyr Thr Asp Pro  Glu Leu Asp Thr Gly  Asp Lys Lys 
    3050                 3055                 3060             


Asp Ile  Phe Asn Glu His Leu  Arg Leu Val Glu Ser  Ala Asn Glu 
    3065                 3070                 3075             


Lys Ala  Glu Arg Glu Ala Leu  Leu Arg Gly Val Glu  Pro Gly Pro 
    3080                 3085                 3090             


Leu Gly  Pro Glu Glu Arg Pro  Pro Pro Ala Ala Asp  Ala Ser Glu 
    3095                 3100                 3105             


Pro Arg  Leu Ala Ser Val Leu  Pro Glu Val Lys Pro  Lys Val Glu 
    3110                 3115                 3120             


Glu Gly  Gly Arg His Pro Ser  Pro Cys Gln Phe Thr  Ile Ala Thr 
    3125                 3130                 3135             


Pro Lys  Val Glu Pro Ala Pro  Ala Ala Asn Ser Leu  Gly Leu Gly 
    3140                 3145                 3150             


Leu Lys  Pro Gly Gln Ser Met  Met Gly Ser Arg Asp  Thr Arg Met 
    3155                 3160                 3165             


Gly Thr  Gly Pro Phe Ser Ser  Ser Gly His Thr Ala  Glu Lys Ala 
    3170                 3175                 3180             


Ser Phe  Gly Ala Thr Gly Gly  Pro Pro Ala His Leu  Leu Thr Pro 
    3185                 3190                 3195             


Ser Pro  Leu Ser Gly Pro Gly  Gly Ser Ser Leu Leu  Glu Lys Phe 
    3200                 3205                 3210             


Glu Leu  Glu Ser Gly Ala Leu  Thr Leu Pro Gly Gly  Pro Ala Ala 
    3215                 3220                 3225             


Ser Gly  Asp Glu Leu Asp Lys  Met Glu Ser Ser Leu  Val Ala Ser 
    3230                 3235                 3240             


Glu Leu  Pro Leu Leu Ile Glu  Asp Leu Leu Glu His  Glu Lys Lys 
    3245                 3250                 3255             


Glu Leu  Gln Lys Lys Gln Gln  Leu Ser Ala Gln Leu  Gln Pro Ala 
    3260                 3265                 3270             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln His Ser Leu  Leu Ser Ala 
    3275                 3280                 3285             


Pro Gly  Pro Ala Gln Ala Met  Ser Leu Pro His Glu  Gly Ser Ser 
    3290                 3295                 3300             


Pro Ser  Leu Ala Gly Ser Gln  Gln Gln Leu Ser Leu  Gly Leu Ala 
    3305                 3310                 3315             


Gly Ala  Arg Gln Pro Gly Leu  Pro Gln Pro Leu Met  Pro Thr Gln 
    3320                 3325                 3330             


Pro Pro  Ala His Ala Leu Gln  Gln Arg Leu Ala Pro  Ser Met Ala 
    3335                 3340                 3345             


Met Val  Ser Asn Gln Gly His  Met Leu Ser Gly Gln  His Gly Gly 
    3350                 3355                 3360             


Gln Ala  Gly Leu Val Pro Gln  Gln Ser Ser Gln Pro  Val Leu Ser 
    3365                 3370                 3375             


Gln Lys  Pro Met Gly Thr Met  Pro Pro Ser Met Cys  Met Lys Pro 
    3380                 3385                 3390             


Gln Gln  Leu Ala Met Gln Gln  Gln Leu Ala Asn Ser  Phe Phe Pro 
    3395                 3400                 3405             


Asp Thr  Asp Leu Asp Lys Phe  Ala Ala Glu Asp Ile  Ile Asp Pro 
    3410                 3415                 3420             


Ile Ala  Lys Ala Lys Met Val  Ala Leu Lys Gly Ile  Lys Lys Val 
    3425                 3430                 3435             


Met Ala  Gln Gly Ser Ile Gly  Val Ala Pro Gly Met  Asn Arg Gln 
    3440                 3445                 3450             


Gln Val  Ser Leu Leu Ala Gln  Arg Leu Ser Gly Gly  Pro Ser Ser 
    3455                 3460                 3465             


Asp Leu  Gln Asn His Val Ala  Ala Gly Ser Gly Gln  Glu Arg Ser 
    3470                 3475                 3480             


Ala Gly  Asp Pro Ser Gln Pro  Arg Pro Asn Pro Pro  Thr Phe Ala 
    3485                 3490                 3495             


Gln Gly  Val Ile Asn Glu Ala  Asp Gln Arg Gln Tyr  Glu Glu Trp 
    3500                 3505                 3510             


Leu Phe  His Thr Gln Gln Leu  Leu Gln Met Gln Leu  Lys Val Leu 
    3515                 3520                 3525             


Glu Glu  Gln Ile Gly Val His  Arg Lys Ser Arg Lys  Ala Leu Cys 
    3530                 3535                 3540             


Ala Lys  Gln Arg Thr Ala Lys  Lys Ala Gly Arg Glu  Phe Pro Glu 
    3545                 3550                 3555             


Ala Asp  Ala Glu Lys Leu Lys  Leu Val Thr Glu Gln  Gln Ser Lys 
    3560                 3565                 3570             


Ile Gln  Lys Gln Leu Asp Gln  Val Arg Lys Gln Gln  Lys Glu His 
    3575                 3580                 3585             


Thr Asn  Leu Met Ala Glu Tyr  Arg Asn Lys Gln Gln  Gln Gln Gln 
    3590                 3595                 3600             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gln His Ser Ala  Val Leu Ala 
    3605                 3610                 3615             


Leu Ser  Pro Ser Gln Ser Pro  Arg Leu Leu Thr Lys  Leu Pro Gly 
    3620                 3625                 3630             


Gln Leu  Leu Pro Gly His Gly  Leu Gln Pro Pro Gln  Gly Pro Pro 
    3635                 3640                 3645             


Gly Gly  Gln Ala Gly Gly Leu  Arg Leu Thr Pro Gly  Gly Met Ala 
    3650                 3655                 3660             


Leu Pro  Gly Gln Pro Gly Gly  Pro Phe Leu Asn Thr  Ala Leu Ala 
    3665                 3670                 3675             


Gln Gln  Gln Gln Gln Gln His  Ser Gly Gly Ala Gly  Ser Leu Ala 
    3680                 3685                 3690             


Gly Pro  Ser Gly Gly Phe Phe  Pro Gly Asn Leu Ala  Leu Arg Ser 
    3695                 3700                 3705             


Leu Gly  Pro Asp Ser Arg Leu  Leu Gln Glu Arg Gln  Leu Gln Leu 
    3710                 3715                 3720             


Gln Gln  Gln Arg Met Gln Leu  Ala Gln Lys Leu Gln  Gln Gln Gln 
    3725                 3730                 3735             


Gln Gln  Gln Gln Gln Gln Gln  His Leu Leu Gly Gln  Val Ala Ile 
    3740                 3745                 3750             


Gln Gln  Gln Gln Gln Gln Gly  Pro Gly Val Gln Thr  Asn Gln Ala 
    3755                 3760                 3765             


Leu Gly  Pro Lys Pro Gln Gly  Leu Met Pro Pro Ser  Ser His Gln 
    3770                 3775                 3780             


Gly Leu  Leu Val Gln Gln Leu  Ser Pro Gln Pro Pro  Gln Gly Pro 
    3785                 3790                 3795             


Gln Gly  Met Leu Gly Pro Ala  Gln Val Ala Val Leu  Gln Gln Gln 
    3800                 3805                 3810             


His Pro  Gly Ala Leu Gly Pro  Gln Gly Pro His Arg  Gln Val Leu 
    3815                 3820                 3825             


Met Thr  Gln Ser Arg Val Leu  Ser Ser Pro Gln Leu  Ala Gln Gln 
    3830                 3835                 3840             


Gly Gln  Gly Leu Met Gly His  Arg Leu Val Thr Ala  Gln Gln Gln 
    3845                 3850                 3855             


Gln Gln  Gln Gln Gln His Gln  Gln Gln Gly Ser Met  Ala Gly Leu 
    3860                 3865                 3870             


Ser His  Leu Gln Gln Ser Leu  Met Ser His Ser Gly  Gln Pro Lys 
    3875                 3880                 3885             


Leu Ser  Ala Gln Pro Met Gly  Ser Leu Gln Gln Leu  Gln Gln Gln 
    3890                 3895                 3900             


Gln Gln  Leu Gln Gln Gln Gln  Gln Leu Gln Gln Gln  Gln Gln Gln 
    3905                 3910                 3915             


Gln Leu  Gln Gln Gln Gln Gln  Leu Gln Gln Gln Gln  Leu Gln Gln 
    3920                 3925                 3930             


Gln Gln  Gln Gln Gln Gln Leu  Gln Gln Gln Gln Gln  Gln Gln Leu 
    3935                 3940                 3945             


Gln Gln  Gln Gln Gln Gln Leu  Gln Gln Gln Gln Gln  Gln Gln Gln 
    3950                 3955                 3960             


Gln Gln  Phe Gln Gln Gln Gln  Gln Gln Gln Gln Met  Gly Leu Leu 
    3965                 3970                 3975             


Asn Gln  Ser Arg Thr Leu Leu  Ser Pro Gln Gln Gln  Gln Gln Gln 
    3980                 3985                 3990             


Gln Val  Ala Leu Gly Pro Gly  Met Pro Ala Lys Pro  Leu Gln His 
    3995                 4000                 4005             


Phe Ser  Ser Pro Gly Ala Leu  Gly Pro Thr Leu Leu  Leu Thr Gly 
    4010                 4015                 4020             


Lys Glu  Gln Asn Thr Val Asp  Pro Ala Val Ser Ser  Glu Ala Thr 
    4025                 4030                 4035             


Glu Gly  Pro Ser Thr His Gln  Gly Gly Pro Leu Ala  Ile Gly Thr 
    4040                 4045                 4050             


Thr Pro  Glu Ser Met Ala Thr  Glu Pro Gly Glu Val  Lys Pro Ser 
    4055                 4060                 4065             


Leu Ser  Gly Asp Ser Gln Leu  Leu Leu Val Gln Pro  Gln Pro Gln 
    4070                 4075                 4080             


Pro Gln  Pro Ser Ser Leu Gln  Leu Gln Pro Pro Leu  Arg Leu Pro 
    4085                 4090                 4095             


Gly Gln  Gln Gln Gln Gln Val  Ser Leu Leu His Thr  Ala Gly Gly 
    4100                 4105                 4110             


Gly Ser  His Gly Gln Leu Gly  Ser Gly Ser Ser Ser  Glu Ala Ser 
    4115                 4120                 4125             


Ser Val  Pro His Leu Leu Ala  Gln Pro Ser Val Ser  Leu Gly Asp 
    4130                 4135                 4140             


Gln Pro  Gly Ser Met Thr Gln  Asn Leu Leu Gly Pro  Gln Gln Pro 
    4145                 4150                 4155             


Met Leu  Glu Arg Pro Met Gln  Asn Asn Thr Gly Pro  Gln Pro Pro 
    4160                 4165                 4170             


Lys Pro  Gly Pro Val Leu Gln  Ser Gly Gln Gly Leu  Pro Gly Val 
    4175                 4180                 4185             


Gly Ile  Met Pro Thr Val Gly  Gln Leu Arg Ala Gln  Leu Gln Gly 
    4190                 4195                 4200             


Val Leu  Ala Lys Asn Pro Gln  Leu Arg His Leu Ser  Pro Gln Gln 
    4205                 4210                 4215             


Gln Gln  Gln Leu Gln Ala Leu  Leu Met Gln Arg Gln  Leu Gln Gln 
    4220                 4225                 4230             


Ser Gln  Ala Val Arg Gln Thr  Pro Pro Tyr Gln Glu  Pro Gly Thr 
    4235                 4240                 4245             


Gln Thr  Ser Pro Leu Gln Gly  Leu Leu Gly Cys Gln  Pro Gln Leu 
    4250                 4255                 4260             


Gly Gly  Phe Pro Gly Pro Gln  Thr Gly Pro Leu Gln  Glu Leu Gly 
    4265                 4270                 4275             


Ala Gly  Pro Arg Pro Gln Gly  Pro Pro Arg Leu Pro  Ala Pro Pro 
    4280                 4285                 4290             


Gly Ala  Leu Ser Thr Gly Pro  Val Leu Gly Pro Val  His Pro Thr 
    4295                 4300                 4305             


Pro Pro  Pro Ser Ser Pro Gln  Glu Pro Lys Arg Pro  Ser Gln Leu 
    4310                 4315                 4320             


Pro Ser  Pro Ser Ser Gln Leu  Pro Thr Glu Ala Gln  Leu Pro Pro 
    4325                 4330                 4335             


Thr His  Pro Gly Thr Pro Lys  Pro Gln Gly Pro Thr  Leu Glu Pro 
    4340                 4345                 4350             


Pro Pro  Gly Arg Val Ser Pro  Ala Ala Ala Gln Leu  Ala Asp Thr 
    4355                 4360                 4365             


Leu Phe  Ser Lys Gly Leu Gly  Pro Trp Asp Pro Pro  Asp Asn Leu 
    4370                 4375                 4380             


Ala Glu  Thr Gln Lys Pro Glu  Gln Ser Ser Leu Val  Pro Gly His 
    4385                 4390                 4395             


Leu Asp  Gln Val Asn Gly Gln  Val Val Pro Glu Ala  Ser Gln Leu 
    4400                 4405                 4410             


Ser Ile  Lys Gln Glu Pro Arg  Glu Glu Pro Cys Ala  Leu Gly Ala 
    4415                 4420                 4425             


Gln Ser  Val Lys Arg Glu Ala  Asn Gly Glu Pro Ile  Gly Ala Pro 
    4430                 4435                 4440             


Gly Thr  Ser Asn His Leu Leu  Leu Ala Gly Pro Arg  Ser Glu Ala 
    4445                 4450                 4455             


Gly His  Leu Leu Leu Gln Lys  Leu Leu Arg Ala Lys  Asn Val Gln 
    4460                 4465                 4470             


Leu Ser  Thr Gly Arg Gly Ser  Glu Gly Leu Arg Ala  Glu Ile Asn 
    4475                 4480                 4485             


Gly His  Ile Asp Ser Lys Leu  Ala Gly Leu Glu Gln  Lys Leu Gln 
    4490                 4495                 4500             


Gly Thr  Pro Ser Asn Lys Glu  Asp Ala Ala Ala Arg  Lys Pro Leu 
    4505                 4510                 4515             


Thr Pro  Lys Pro Lys Arg Val  Gln Lys Ala Ser Asp  Arg Leu Val 
    4520                 4525                 4530             


Ser Ser  Arg Lys Lys Leu Arg  Lys Glu Asp Gly Val  Arg Ala Ser 
    4535                 4540                 4545             


Glu Ala  Leu Leu Lys Gln Leu  Lys Gln Glu Leu Ser  Leu Leu Pro 
    4550                 4555                 4560             


Leu Thr  Glu Pro Ala Ile Thr  Ala Asn Phe Ser Leu  Phe Ala Pro 
    4565                 4570                 4575             


Phe Gly  Ser Gly Cys Pro Val  Asn Gly Gln Ser Gln  Leu Arg Gly 
    4580                 4585                 4590             


Ala Phe  Gly Ser Gly Ala Leu  Pro Thr Gly Pro Asp  Tyr Tyr Ser 
    4595                 4600                 4605             


Gln Leu  Leu Thr Lys Asn Asn  Leu Ser Asn Pro Pro  Thr Pro Pro 
    4610                 4615                 4620             


Ser Ser  Leu Pro Pro Thr Pro  Pro Pro Ser Val Gln  Gln Lys Met 
    4625                 4630                 4635             


Val Asn  Gly Val Thr Pro Ser  Glu Glu Leu Gly Glu  His Pro Lys 
    4640                 4645                 4650             


Asp Ala  Ala Ser Ala Arg Asp  Ser Glu Arg Ala Leu  Arg Asp Thr 
    4655                 4660                 4665             


Ser Glu  Val Lys Ser Leu Asp  Leu Leu Ala Ala Leu  Pro Thr Pro 
    4670                 4675                 4680             


Pro His  Asn Gln Thr Glu Asp  Val Arg Met Glu Ser  Asp Glu Asp 
    4685                 4690                 4695             


Ser Asp  Ser Pro Asp Ser Ile  Val Pro Ala Ser Ser  Pro Glu Ser 
    4700                 4705                 4710             


Ile Leu  Gly Glu Glu Ala Pro  Arg Phe Pro His Leu  Gly Ser Gly 
    4715                 4720                 4725             


Arg Trp  Glu Gln Glu Asp Arg  Ala Leu Ser Pro Val  Ile Pro Leu 
    4730                 4735                 4740             


Ile Pro  Arg Ala Ser Ile Pro  Val Phe Pro Asp Thr  Lys Pro Tyr 
    4745                 4750                 4755             


Gly Ala  Leu Gly Leu Glu Val  Pro Gly Lys Leu Pro  Val Thr Thr 
    4760                 4765                 4770             


Trp Glu  Lys Gly Lys Gly Ser  Glu Val Ser Val Met  Leu Thr Val 
    4775                 4780                 4785             


Ser Ala  Ala Ala Ala Lys Asn  Leu Asn Gly Val Met  Val Ala Val 
    4790                 4795                 4800             


Ala Glu  Leu Leu Ser Met Lys  Ile Pro Asn Ser Tyr  Glu Val Leu 
    4805                 4810                 4815             


Phe Pro  Glu Ser Pro Ala Arg  Ala Gly Thr Glu Pro  Lys Lys Gly 
    4820                 4825                 4830             


Glu Ala  Glu Gly Pro Gly Gly  Lys Glu Lys Gly Leu  Glu Gly Lys 
    4835                 4840                 4845             


Ser Pro  Asp Thr Gly Pro Asp  Trp Leu Lys Gln Phe  Asp Ala Val 
    4850                 4855                 4860             


Leu Pro  Gly Tyr Thr Leu Lys  Ser Gln Leu Asp Ile  Leu Ser Leu 
    4865                 4870                 4875             


Leu Lys  Gln Glu Ser Pro Ala  Pro Glu Pro Pro Thr  Gln His Ser 
    4880                 4885                 4890             


Tyr Thr  Tyr Asn Val Ser Asn  Leu Asp Val Arg Gln  Leu Ser Ala 
    4895                 4900                 4905             


Pro Pro  Pro Glu Glu Pro Ser  Pro Pro Pro Ser Pro  Leu Ala Pro 
    4910                 4915                 4920             


Ser Pro  Ala Ser Pro Pro Thr  Glu Pro Leu Val Glu  Leu Pro Thr 
    4925                 4930                 4935             


Glu Pro  Leu Ala Glu Pro Pro  Val Pro Ser Pro Leu  Pro Leu Ala 
    4940                 4945                 4950             


Ser Ser  Pro Glu Ser Ala Arg  Pro Lys Pro Arg Ala  Arg Pro Pro 
    4955                 4960                 4965             


Glu Glu  Gly Glu Asp Ser Arg  Pro Pro Arg Leu Lys  Lys Trp Lys 
    4970                 4975                 4980             


Gly Val  Arg Trp Lys Arg Leu  Arg Leu Leu Leu Thr  Ile Gln Lys 
    4985                 4990                 4995             


Gly Ser  Gly Arg Gln Glu Asp  Glu Arg Glu Val Ala  Glu Phe Met 
    5000                 5005                 5010             


Glu Gln  Leu Gly Thr Ala Leu  Arg Pro Asp Lys Val  Pro Arg Asp 
    5015                 5020                 5025             


Met Arg  Arg Cys Cys Phe Cys  His Glu Glu Gly Asp  Gly Ala Thr 
    5030                 5035                 5040             


Asp Gly  Pro Ala Arg Leu Leu  Asn Leu Asp Leu Asp  Leu Trp Val 
    5045                 5050                 5055             


His Leu  Asn Cys Ala Leu Trp  Ser Thr Glu Val Tyr  Glu Thr Gln 
    5060                 5065                 5070             


Gly Gly  Ala Leu Met Asn Val  Glu Val Ala Leu His  Arg Gly Leu 
    5075                 5080                 5085             


Leu Thr  Lys Cys Ser Leu Cys  Gln Arg Thr Gly Ala  Thr Ser Ser 
    5090                 5095                 5100             


Cys Asn  Arg Met Arg Cys Pro  Asn Val Tyr His Phe  Ala Cys Ala 
    5105                 5110                 5115             


Ile Arg  Ala Lys Cys Met Phe  Phe Lys Asp Lys Thr  Met Leu Cys 
    5120                 5125                 5130             


Pro Met  His Lys Ile Lys Gly  Pro Cys Glu Gln Glu  Leu Ser Ser 
    5135                 5140                 5145             


Phe Ala  Val Phe Arg Arg Val  Tyr Ile Glu Arg Asp  Glu Val Lys 
    5150                 5155                 5160             


Gln Ile  Ala Ser Ile Ile Gln  Arg Gly Glu Arg Leu  His Met Phe 
    5165                 5170                 5175             


Arg Val  Gly Gly Leu Val Phe  His Ala Ile Gly Gln  Leu Leu Pro 
    5180                 5185                 5190             


His Gln  Met Ala Asp Phe His  Ser Ala Thr Ala Leu  Tyr Pro Val 
    5195                 5200                 5205             


Gly Tyr  Glu Ala Thr Arg Ile  Tyr Trp Ser Leu Arg  Thr Asn Asn 
    5210                 5215                 5220             


Arg Arg  Cys Cys Tyr Arg Cys  Ser Ile Gly Glu Asn  Asn Gly Arg 
    5225                 5230                 5235             


Pro Glu  Phe Val Ile Lys Val  Ile Glu Gln Gly Leu  Glu Asp Leu 
    5240                 5245                 5250             


Val Phe  Thr Asp Ala Ser Pro  Gln Ala Val Trp Asn  Arg Ile Ile 
    5255                 5260                 5265             


Glu Pro  Val Ala Ala Met Arg  Lys Glu Ala Asp Met  Leu Arg Leu 
    5270                 5275                 5280             


Phe Pro  Glu Tyr Leu Lys Gly  Glu Glu Leu Phe Gly  Leu Thr Val 
    5285                 5290                 5295             


His Ala  Val Leu Arg Ile Ala  Glu Ser Leu Pro Gly  Val Glu Ser 
    5300                 5305                 5310             


Cys Gln  Asn Tyr Leu Phe Arg  Tyr Gly Arg His Pro  Leu Met Glu 
    5315                 5320                 5325             


Leu Pro  Leu Met Ile Asn Pro  Thr Gly Cys Ala Arg  Ser Glu Pro 
    5330                 5335                 5340             


Lys Ile  Leu Thr His Tyr Lys  Arg Pro His Thr Leu  Asn Ser Thr 
    5345                 5350                 5355             


Ser Met  Ser Lys Ala Tyr Gln  Ser Thr Phe Thr Gly  Glu Thr Asn 
    5360                 5365                 5370             


Thr Pro  Tyr Ser Lys Gln Phe  Val His Ser Lys Ser  Ser Gln Tyr 
    5375                 5380                 5385             


Arg Arg  Leu Arg Thr Glu Trp  Lys Asn Asn Val Tyr  Leu Ala Arg 
    5390                 5395                 5400             


Ser Arg  Ile Gln Gly Leu Gly  Leu Tyr Ala Ala Lys  Asp Leu Glu 
    5405                 5410                 5415             


Lys His  Thr Met Val Ile Glu  Tyr Ile Gly Thr Ile  Ile Arg Asn 
    5420                 5425                 5430             


Glu Val  Ala Asn Arg Arg Glu  Lys Ile Tyr Glu Glu  Gln Asn Arg 
    5435                 5440                 5445             


Gly Ile  Tyr Met Phe Arg Ile  Asn Asn Glu His Val  Ile Asp Ala 
    5450                 5455                 5460             


Thr Leu  Thr Gly Gly Pro Ala  Arg Tyr Ile Asn His  Ser Cys Ala 
    5465                 5470                 5475             


Pro Asn  Cys Val Ala Glu Val  Val Thr Phe Asp Lys  Glu Asp Lys 
    5480                 5485                 5490             


Ile Ile  Ile Ile Ser Ser Arg  Arg Ile Pro Lys Gly  Glu Glu Leu 
    5495                 5500                 5505             


Thr Tyr  Asp Tyr Gln Phe Asp  Phe Glu Asp Asp Gln  His Lys Ile 
    5510                 5515                 5520             


Pro Cys  His Cys Gly Ala Trp  Asn Cys Arg Lys Trp  Met Asn 
    5525                 5530                 5535         


<210> 226
<211> 1442
<212> PRT
<213> Homo sapiens

<400> 226
Met Ser Ile Ala Ile Pro Leu Gly Val Thr Thr Ser Asp Thr Ser Tyr 
1               5                   10                  15      


Ser Asp Met Ala Ala Gly Ser Asp Pro Glu Ser Val Glu Ala Ser Pro 
            20                  25                  30          


Ala Val Asn Glu Lys Ser Val Tyr Ser Thr His Asn Tyr Gly Thr Thr 
        35                  40                  45              


Gln Arg His Gly Cys Arg Gly Leu Pro Tyr Ala Thr Ile Ile Pro Arg 
    50                  55                  60                  


Ser Asp Leu Asn Gly Leu Pro Ser Pro Val Glu Glu Arg Cys Gly Asp 
65                  70                  75                  80  


Ser Pro Asn Ser Glu Gly Glu Thr Val Pro Thr Trp Cys Pro Cys Gly 
                85                  90                  95      


Leu Ser Gln Asp Gly Phe Leu Leu Asn Cys Asp Lys Cys Arg Gly Met 
            100                 105                 110         


Ser Arg Gly Lys Val Ile Arg Leu His Arg Arg Lys Gln Asp Asn Ile 
        115                 120                 125             


Ser Gly Gly Asp Ser Ser Ala Thr Glu Ser Trp Asp Glu Glu Leu Ser 
    130                 135                 140                 


Pro Ser Thr Val Leu Tyr Thr Ala Thr Gln His Thr Pro Thr Ser Ile 
145                 150                 155                 160 


Thr Leu Thr Val Arg Arg Thr Lys Pro Lys Lys Arg Lys Lys Ser Pro 
                165                 170                 175     


Glu Lys Gly Arg Ala Ala Pro Lys Thr Lys Lys Ile Lys Asn Ser Pro 
            180                 185                 190         


Ser Glu Ala Gln Asn Leu Asp Glu Asn Thr Thr Glu Gly Trp Glu Asn 
        195                 200                 205             


Arg Ile Arg Leu Trp Thr Asp Gln Tyr Glu Glu Ala Phe Thr Asn Gln 
    210                 215                 220                 


Tyr Ser Ala Asp Val Gln Asn Ala Leu Glu Gln His Leu His Ser Ser 
225                 230                 235                 240 


Lys Glu Phe Val Gly Lys Pro Thr Ile Leu Asp Thr Ile Asn Lys Thr 
                245                 250                 255     


Glu Leu Ala Cys Asn Asn Thr Val Ile Gly Ser Gln Met Gln Leu Gln 
            260                 265                 270         


Leu Gly Arg Val Thr Arg Val Gln Lys His Arg Lys Ile Leu Arg Ala 
        275                 280                 285             


Ala Arg Asp Leu Ala Leu Asp Thr Leu Ile Ile Glu Tyr Arg Gly Lys 
    290                 295                 300                 


Val Met Leu Arg Gln Gln Phe Glu Val Asn Gly His Phe Phe Lys Lys 
305                 310                 315                 320 


Pro Tyr Pro Phe Val Leu Phe Tyr Ser Lys Phe Asn Gly Val Glu Met 
                325                 330                 335     


Cys Val Asp Ala Arg Thr Phe Gly Asn Asp Ala Arg Phe Ile Arg Arg 
            340                 345                 350         


Ser Cys Thr Pro Asn Ala Glu Val Arg His Met Ile Ala Asp Gly Met 
        355                 360                 365             


Ile His Leu Cys Ile Tyr Ala Val Ser Ala Ile Thr Lys Asp Ala Glu 
    370                 375                 380                 


Val Thr Ile Ala Phe Asp Tyr Glu Tyr Ser Asn Cys Asn Tyr Lys Val 
385                 390                 395                 400 


Asp Cys Ala Cys His Lys Gly Asn Arg Asn Cys Pro Ile Gln Lys Arg 
                405                 410                 415     


Asn Pro Asn Ala Thr Glu Leu Pro Leu Leu Pro Pro Pro Pro Ser Leu 
            420                 425                 430         


Pro Thr Ile Gly Ala Glu Thr Arg Arg Arg Lys Ala Arg Arg Lys Glu 
        435                 440                 445             


Leu Glu Met Glu Gln Gln Asn Glu Ala Ser Glu Glu Asn Asn Asp Gln 
    450                 455                 460                 


Gln Ser Gln Glu Val Pro Glu Lys Val Thr Val Ser Ser Asp His Glu 
465                 470                 475                 480 


Glu Val Asp Asn Pro Glu Glu Lys Pro Glu Glu Glu Lys Glu Glu Val 
                485                 490                 495     


Ile Asp Asp Gln Glu Asn Leu Ala His Ser Arg Arg Thr Arg Glu Asp 
            500                 505                 510         


Arg Lys Val Glu Ala Ile Met His Ala Phe Glu Asn Leu Glu Lys Arg 
        515                 520                 525             


Lys Lys Arg Arg Asp Gln Pro Leu Glu Gln Ser Asn Ser Asp Val Glu 
    530                 535                 540                 


Ile Thr Thr Thr Thr Ser Glu Thr Pro Val Gly Glu Glu Thr Lys Thr 
545                 550                 555                 560 


Glu Ala Pro Glu Ser Glu Val Ser Asn Ser Val Ser Asn Val Thr Ile 
                565                 570                 575     


Pro Ser Thr Pro Gln Ser Val Gly Val Asn Thr Arg Arg Ser Ser Gln 
            580                 585                 590         


Ala Gly Asp Ile Ala Ala Glu Lys Leu Val Pro Lys Pro Pro Pro Ala 
        595                 600                 605             


Lys Pro Ser Arg Pro Arg Pro Lys Ser Arg Ile Ser Arg Tyr Arg Thr 
    610                 615                 620                 


Ser Ser Ala Gln Arg Leu Lys Arg Gln Lys Gln Ala Asn Ala Gln Gln 
625                 630                 635                 640 


Ala Glu Leu Ser Gln Ala Ala Leu Glu Glu Gly Gly Ser Asn Ser Leu 
                645                 650                 655     


Val Thr Pro Thr Glu Ala Gly Ser Leu Asp Ser Ser Gly Glu Asn Arg 
            660                 665                 670         


Pro Leu Thr Gly Ser Asp Pro Thr Val Val Ser Ile Thr Gly Ser His 
        675                 680                 685             


Val Asn Arg Ala Ala Ser Lys Tyr Pro Lys Thr Lys Lys Tyr Leu Val 
    690                 695                 700                 


Thr Glu Trp Leu Asn Asp Lys Ala Glu Lys Gln Glu Cys Pro Val Glu 
705                 710                 715                 720 


Cys Pro Leu Arg Ile Thr Thr Asp Pro Thr Val Leu Ala Thr Thr Leu 
                725                 730                 735     


Asn Met Leu Pro Gly Leu Ile His Ser Pro Leu Ile Cys Thr Thr Pro 
            740                 745                 750         


Lys His Tyr Ile Arg Phe Gly Ser Pro Phe Ile Pro Glu Arg Arg Arg 
        755                 760                 765             


Arg Pro Leu Leu Pro Asp Gly Thr Phe Ser Ser Cys Lys Lys Arg Trp 
    770                 775                 780                 


Ile Lys Gln Ala Leu Glu Glu Gly Met Thr Gln Thr Ser Ser Val Pro 
785                 790                 795                 800 


Gln Glu Thr Arg Thr Gln His Leu Tyr Gln Ser Asn Glu Asn Ser Ser 
                805                 810                 815     


Ser Ser Ser Ile Cys Lys Asp Asn Ala Asp Leu Leu Ser Pro Leu Lys 
            820                 825                 830         


Lys Trp Lys Ser Arg Tyr Leu Met Glu Gln Asn Val Thr Lys Leu Leu 
        835                 840                 845             


Arg Pro Leu Ser Pro Val Thr Pro Pro Pro Pro Asn Ser Gly Ser Lys 
    850                 855                 860                 


Ser Pro Gln Leu Ala Thr Pro Gly Ser Ser His Pro Gly Glu Glu Glu 
865                 870                 875                 880 


Cys Arg Asn Gly Tyr Ser Leu Met Phe Ser Pro Val Thr Ser Leu Thr 
                885                 890                 895     


Thr Ala Ser Arg Cys Asn Thr Pro Leu Gln Phe Glu Leu Cys His Arg 
            900                 905                 910         


Lys Asp Leu Asp Leu Ala Lys Val Gly Tyr Leu Asp Ser Asn Thr Asn 
        915                 920                 925             


Ser Cys Ala Asp Arg Pro Ser Leu Leu Asn Ser Gly His Ser Asp Leu 
    930                 935                 940                 


Ala Pro His Pro Ser Leu Gly Pro Thr Ser Glu Thr Gly Phe Pro Ser 
945                 950                 955                 960 


Arg Ser Gly Asp Gly His Gln Thr Leu Val Arg Asn Ser Asp Gln Ala 
                965                 970                 975     


Phe Arg Thr Glu Phe Asn Leu Met Tyr Ala Tyr Ser Pro Leu Asn Ala 
            980                 985                 990         


Met Pro Arg Ala Asp Gly Leu Tyr  Arg Gly Ser Pro Leu  Val Gly Asp 
        995                 1000                 1005             


Arg Lys  Pro Leu His Leu Asp  Gly Gly Tyr Cys Ser  Pro Ala Glu 
    1010                 1015                 1020             


Gly Phe  Ser Ser Arg Tyr Glu  His Gly Leu Met Lys  Asp Leu Ser 
    1025                 1030                 1035             


Arg Gly  Ser Leu Ser Pro Gly  Gly Glu Arg Ala Cys  Glu Gly Val 
    1040                 1045                 1050             


Pro Ser  Ala Pro Gln Asn Pro  Pro Gln Arg Lys Lys  Val Ser Leu 
    1055                 1060                 1065             


Leu Glu  Tyr Arg Lys Arg Lys  Gln Glu Ala Lys Glu  Asn Ser Ala 
    1070                 1075                 1080             


Gly Gly  Gly Gly Asp Ser Ala  Gln Ser Lys Ser Lys  Ser Ala Gly 
    1085                 1090                 1095             


Ala Gly  Gln Gly Ser Ser Asn  Ser Val Ser Asp Thr  Gly Ala His 
    1100                 1105                 1110             


Gly Val  Gln Gly Ser Ser Ala  Arg Thr Pro Ser Ser  Pro His Lys 
    1115                 1120                 1125             


Lys Phe  Ser Pro Ser His Ser  Ser Met Ser His Leu  Glu Ala Val 
    1130                 1135                 1140             


Ser Pro  Ser Asp Ser Arg Gly  Thr Ser Ser Ser His  Cys Arg Pro 
    1145                 1150                 1155             


Gln Glu  Asn Ile Ser Ser Arg  Trp Met Val Pro Thr  Ser Val Glu 
    1160                 1165                 1170             


Arg Leu  Arg Glu Gly Gly Ser  Ile Pro Lys Val Leu  Arg Ser Ser 
    1175                 1180                 1185             


Val Arg  Val Ala Gln Lys Gly  Glu Pro Ser Pro Thr  Trp Glu Ser 
    1190                 1195                 1200             


Asn Ile  Thr Glu Lys Asp Ser  Asp Pro Ala Asp Gly  Glu Gly Pro 
    1205                 1210                 1215             


Glu Thr  Leu Ser Ser Ala Leu  Ser Lys Gly Ala Thr  Val Tyr Ser 
    1220                 1225                 1230             


Pro Ser  Arg Tyr Ser Tyr Gln  Leu Leu Gln Cys Asp  Ser Pro Arg 
    1235                 1240                 1245             


Thr Glu  Ser Gln Ser Leu Leu  Gln Gln Ser Ser Ser  Pro Phe Arg 
    1250                 1255                 1260             


Gly His  Pro Thr Gln Ser Pro  Gly Tyr Ser Tyr Arg  Thr Thr Ala 
    1265                 1270                 1275             


Leu Arg  Pro Gly Asn Pro Pro  Ser His Gly Ser Ser  Glu Ser Ser 
    1280                 1285                 1290             


Leu Ser  Ser Thr Ser Tyr Ser  Ser Pro Ala His Pro  Val Ser Thr 
    1295                 1300                 1305             


Asp Ser  Leu Ala Pro Phe Thr  Gly Thr Pro Gly Tyr  Phe Ser Ser 
    1310                 1315                 1320             


Gln Pro  His Ser Gly Asn Ser  Thr Gly Ser Asn Leu  Pro Arg Arg 
    1325                 1330                 1335             


Ser Cys  Pro Ser Ser Ala Ala  Ser Pro Thr Leu Gln  Gly Pro Ser 
    1340                 1345                 1350             


Asp Ser  Pro Thr Ser Asp Ser  Val Ser Gln Ser Ser  Thr Gly Thr 
    1355                 1360                 1365             


Leu Ser  Ser Thr Ser Phe Pro  Gln Asn Ser Arg Ser  Ser Leu Pro 
    1370                 1375                 1380             


Ser Asp  Leu Arg Thr Ile Ser  Leu Pro Ser Ala Gly  Gln Ser Ala 
    1385                 1390                 1395             


Val Tyr  Gln Ala Ser Arg Val  Ser Ala Val Ser Asn  Ser Gln His 
    1400                 1405                 1410             


Tyr Pro  His Arg Gly Ser Gly  Gly Val His Gln Tyr  Arg Leu Gln 
    1415                 1420                 1425             


Pro Leu  Gln Gly Ser Gly Val  Lys Thr Gln Thr Gly  Leu Ser 
    1430                 1435                 1440         


<210> 227
<211> 1214
<212> PRT
<213> Homo sapiens

<400> 227
Met Lys Gln Pro Ile Met Ala Asp Gly Pro Arg Cys Lys Arg Arg Lys 
1               5                   10                  15      


Gln Ala Asn Pro Arg Arg Lys Asn Val Val Asn Tyr Asp Asn Val Val 
            20                  25                  30          


Asp Thr Gly Ser Glu Thr Asp Glu Glu Asp Lys Leu His Ile Ala Glu 
        35                  40                  45              


Asp Asp Gly Ile Ala Asn Pro Leu Asp Gln Glu Thr Ser Pro Ala Ser 
    50                  55                  60                  


Val Pro Asn His Glu Ser Ser Pro His Val Ser Gln Ala Leu Leu Pro 
65                  70                  75                  80  


Arg Glu Glu Glu Glu Asp Glu Ile Arg Glu Gly Gly Val Glu His Pro 
                85                  90                  95      


Trp His Asn Asn Glu Ile Leu Gln Ala Ser Val Asp Gly Pro Glu Glu 
            100                 105                 110         


Met Lys Glu Asp Tyr Asp Thr Met Gly Pro Glu Ala Thr Ile Gln Thr 
        115                 120                 125             


Ala Ile Asn Asn Gly Thr Val Lys Asn Ala Asn Cys Thr Ser Asp Phe 
    130                 135                 140                 


Glu Glu Tyr Phe Ala Lys Arg Lys Leu Glu Glu Arg Asp Gly His Ala 
145                 150                 155                 160 


Val Ser Ile Glu Glu Tyr Leu Gln Arg Ser Asp Thr Ala Ile Ile Tyr 
                165                 170                 175     


Pro Glu Ala Pro Glu Glu Leu Ser Arg Leu Gly Thr Pro Glu Ala Asn 
            180                 185                 190         


Gly Gln Glu Glu Asn Asp Leu Pro Pro Gly Thr Pro Asp Ala Phe Ala 
        195                 200                 205             


Gln Leu Leu Thr Cys Pro Tyr Cys Asp Arg Gly Tyr Lys Arg Leu Thr 
    210                 215                 220                 


Ser Leu Lys Glu His Ile Lys Tyr Arg His Glu Lys Asn Glu Glu Asn 
225                 230                 235                 240 


Phe Ser Cys Pro Leu Cys Ser Tyr Thr Phe Ala Tyr Arg Thr Gln Leu 
                245                 250                 255     


Glu Arg His Met Val Thr His Lys Pro Gly Thr Asp Gln His Gln Met 
            260                 265                 270         


Leu Thr Gln Gly Ala Gly Asn Arg Lys Phe Lys Cys Thr Glu Cys Gly 
        275                 280                 285             


Lys Ala Phe Lys Tyr Lys His His Leu Lys Glu His Leu Arg Ile His 
    290                 295                 300                 


Ser Gly Glu Lys Pro Tyr Glu Cys Pro Asn Cys Lys Lys Arg Phe Ser 
305                 310                 315                 320 


His Ser Gly Ser Tyr Ser Ser His Ile Ser Ser Lys Lys Cys Ile Gly 
                325                 330                 335     


Leu Ile Ser Val Asn Gly Arg Met Arg Asn Asn Ile Lys Thr Gly Ser 
            340                 345                 350         


Ser Pro Asn Ser Val Ser Ser Ser Pro Thr Asn Ser Ala Ile Thr Gln 
        355                 360                 365             


Leu Arg Asn Lys Leu Glu Asn Gly Lys Pro Leu Ser Met Ser Glu Gln 
    370                 375                 380                 


Thr Gly Leu Leu Lys Ile Lys Thr Glu Pro Leu Asp Phe Asn Asp Tyr 
385                 390                 395                 400 


Lys Val Leu Met Ala Thr His Gly Phe Ser Gly Thr Ser Pro Phe Met 
                405                 410                 415     


Asn Gly Gly Leu Gly Ala Thr Ser Pro Leu Gly Val His Pro Ser Ala 
            420                 425                 430         


Gln Ser Pro Met Gln His Leu Gly Val Gly Met Glu Ala Pro Leu Leu 
        435                 440                 445             


Gly Phe Pro Thr Met Asn Ser Asn Leu Ser Glu Val Gln Lys Val Leu 
    450                 455                 460                 


Gln Ile Val Asp Asn Thr Val Ser Arg Gln Lys Met Asp Cys Lys Ala 
465                 470                 475                 480 


Glu Glu Ile Ser Lys Leu Lys Gly Tyr His Met Lys Asp Pro Cys Ser 
                485                 490                 495     


Gln Pro Glu Glu Gln Gly Val Thr Ser Pro Asn Ile Pro Pro Val Gly 
            500                 505                 510         


Leu Pro Val Val Ser His Asn Gly Ala Thr Lys Ser Ile Ile Asp Tyr 
        515                 520                 525             


Thr Leu Glu Lys Val Asn Glu Ala Lys Ala Cys Leu Gln Ser Leu Thr 
    530                 535                 540                 


Thr Asp Ser Arg Arg Gln Ile Ser Asn Ile Lys Lys Glu Lys Leu Arg 
545                 550                 555                 560 


Thr Leu Ile Asp Leu Val Thr Asp Asp Lys Met Ile Glu Asn His Asn 
                565                 570                 575     


Ile Ser Thr Pro Phe Ser Cys Gln Phe Cys Lys Glu Ser Phe Pro Gly 
            580                 585                 590         


Pro Ile Pro Leu His Gln His Glu Arg Tyr Leu Cys Lys Met Asn Glu 
        595                 600                 605             


Glu Ile Lys Ala Val Leu Gln Pro His Glu Asn Ile Val Pro Asn Lys 
    610                 615                 620                 


Ala Gly Val Phe Val Asp Asn Lys Ala Leu Leu Leu Ser Ser Val Leu 
625                 630                 635                 640 


Ser Glu Lys Gly Met Thr Ser Pro Ile Asn Pro Tyr Lys Asp His Met 
                645                 650                 655     


Ser Val Leu Lys Ala Tyr Tyr Ala Met Asn Met Glu Pro Asn Ser Asp 
            660                 665                 670         


Glu Leu Leu Lys Ile Ser Ile Ala Val Gly Leu Pro Gln Glu Phe Val 
        675                 680                 685             


Lys Glu Trp Phe Glu Gln Arg Lys Val Tyr Gln Tyr Ser Asn Ser Arg 
    690                 695                 700                 


Ser Pro Ser Leu Glu Arg Ser Ser Lys Pro Leu Ala Pro Asn Ser Asn 
705                 710                 715                 720 


Pro Pro Thr Lys Asp Ser Leu Leu Pro Arg Ser Pro Val Lys Pro Met 
                725                 730                 735     


Asp Ser Ile Thr Ser Pro Ser Ile Ala Glu Leu His Asn Ser Val Thr 
            740                 745                 750         


Asn Cys Asp Pro Pro Leu Arg Leu Thr Lys Pro Ser His Phe Thr Asn 
        755                 760                 765             


Ile Lys Pro Val Glu Lys Leu Asp His Ser Arg Ser Asn Thr Pro Ser 
    770                 775                 780                 


Pro Leu Asn Leu Ser Ser Thr Ser Ser Lys Asn Ser His Ser Ser Ser 
785                 790                 795                 800 


Tyr Thr Pro Asn Ser Phe Ser Ser Glu Glu Leu Gln Ala Glu Pro Leu 
                805                 810                 815     


Asp Leu Ser Leu Pro Lys Gln Met Lys Glu Pro Lys Ser Ile Ile Ala 
            820                 825                 830         


Thr Lys Asn Lys Thr Lys Ala Ser Ser Ile Ser Leu Asp His Asn Ser 
        835                 840                 845             


Val Ser Ser Ser Ser Glu Asn Ser Asp Glu Pro Leu Asn Leu Thr Phe 
    850                 855                 860                 


Ile Lys Lys Glu Phe Ser Asn Ser Asn Asn Leu Asp Asn Lys Ser Thr 
865                 870                 875                 880 


Asn Pro Val Phe Ser Met Asn Pro Phe Ser Ala Lys Pro Leu Tyr Thr 
                885                 890                 895     


Ala Leu Pro Pro Gln Ser Ala Phe Pro Pro Ala Thr Phe Met Pro Pro 
            900                 905                 910         


Val Gln Thr Ser Ile Pro Gly Leu Arg Pro Tyr Pro Gly Leu Asp Gln 
        915                 920                 925             


Met Ser Phe Leu Pro His Met Ala Tyr Thr Tyr Pro Thr Gly Ala Ala 
    930                 935                 940                 


Thr Phe Ala Asp Met Gln Gln Arg Arg Lys Tyr Gln Arg Lys Gln Gly 
945                 950                 955                 960 


Phe Gln Gly Glu Leu Leu Asp Gly Ala Gln Asp Tyr Met Ser Gly Leu 
                965                 970                 975     


Asp Asp Met Thr Asp Ser Asp Ser Cys Leu Ser Arg Lys Lys Ile Lys 
            980                 985                 990         


Lys Thr Glu Ser Gly Met Tyr Ala  Cys Asp Leu Cys Asp  Lys Thr Phe 
        995                 1000                 1005             


Gln Lys  Ser Ser Ser Leu Leu  Arg His Lys Tyr Glu  His Thr Gly 
    1010                 1015                 1020             


Lys Arg  Pro His Gln Cys Gln  Ile Cys Lys Lys Ala  Phe Lys His 
    1025                 1030                 1035             


Lys His  His Leu Ile Glu His  Ser Arg Leu His Ser  Gly Glu Lys 
    1040                 1045                 1050             


Pro Tyr  Gln Cys Asp Lys Cys  Gly Lys Arg Phe Ser  His Ser Gly 
    1055                 1060                 1065             


Ser Tyr  Ser Gln His Met Asn  His Arg Tyr Ser Tyr  Cys Lys Arg 
    1070                 1075                 1080             


Glu Ala  Glu Glu Arg Glu Ala  Ala Glu Arg Glu Ala  Arg Glu Lys 
    1085                 1090                 1095             


Gly His  Leu Glu Pro Thr Glu  Leu Leu Met Asn Arg  Ala Tyr Leu 
    1100                 1105                 1110             


Gln Ser  Ile Thr Pro Gln Gly  Tyr Ser Asp Ser Glu  Glu Arg Glu 
    1115                 1120                 1125             


Ser Met  Pro Arg Asp Gly Glu  Ser Glu Lys Glu His  Glu Lys Glu 
    1130                 1135                 1140             


Gly Glu  Asp Gly Tyr Gly Lys  Leu Gly Arg Gln Asp  Gly Asp Glu 
    1145                 1150                 1155             


Glu Phe  Glu Glu Glu Glu Glu  Glu Ser Glu Asn Lys  Ser Met Asp 
    1160                 1165                 1170             


Thr Asp  Pro Glu Thr Ile Arg  Asp Glu Glu Glu Thr  Gly Asp His 
    1175                 1180                 1185             


Ser Met  Asp Asp Ser Ser Glu  Asp Gly Lys Met Glu  Thr Lys Ser 
    1190                 1195                 1200             


Asp His  Glu Glu Asp Asn Met  Glu Asp Gly Met 
    1205                 1210                 


<210> 228
<211> 1673
<212> PRT
<213> Homo sapiens

<400> 228
Met Trp Arg Ala Glu Gly Lys Trp Leu Pro Lys Thr Ser Arg Lys Ser 
1               5                   10                  15      


Val Ser Gln Ser Val Phe Cys Gly Thr Ser Thr Tyr Cys Val Leu Asn 
            20                  25                  30          


Thr Val Pro Pro Ile Glu Asp Asp His Gly Asn Ser Asn Ser Ser His 
        35                  40                  45              


Val Lys Ile Phe Leu Pro Lys Lys Leu Leu Glu Cys Leu Pro Lys Cys 
    50                  55                  60                  


Ser Ser Leu Pro Lys Glu Arg His Arg Trp Asn Thr Asn Glu Glu Ile 
65                  70                  75                  80  


Ala Ala Tyr Leu Ile Thr Phe Glu Lys His Glu Glu Trp Leu Thr Thr 
                85                  90                  95      


Ser Pro Lys Thr Arg Pro Gln Asn Gly Ser Met Ile Leu Tyr Asn Arg 
            100                 105                 110         


Lys Lys Val Lys Tyr Arg Lys Asp Gly Tyr Cys Trp Lys Lys Arg Lys 
        115                 120                 125             


Asp Gly Lys Thr Thr Arg Glu Asp His Met Lys Leu Lys Val Gln Gly 
    130                 135                 140                 


Val Glu Cys Leu Tyr Gly Cys Tyr Val His Ser Ser Ile Ile Pro Thr 
145                 150                 155                 160 


Phe His Arg Arg Cys Tyr Trp Leu Leu Gln Asn Pro Asp Ile Val Leu 
                165                 170                 175     


Val His Tyr Leu Asn Val Pro Ala Ile Glu Asp Cys Gly Lys Pro Cys 
            180                 185                 190         


Gly Pro Ile Leu Cys Ser Ile Asn Thr Asp Lys Lys Glu Trp Ala Lys 
        195                 200                 205             


Trp Thr Lys Glu Glu Leu Ile Gly Gln Leu Lys Pro Met Phe His Gly 
    210                 215                 220                 


Ile Lys Trp Thr Cys Ser Asn Gly Asn Ser Ser Ser Gly Phe Ser Val 
225                 230                 235                 240 


Glu Gln Leu Val Gln Gln Ile Leu Asp Ser His Gln Thr Lys Pro Gln 
                245                 250                 255     


Pro Arg Thr His Asn Cys Leu Cys Thr Gly Ser Leu Gly Ala Gly Gly 
            260                 265                 270         


Ser Val His His Lys Cys Asn Ser Ala Lys His Arg Ile Ile Ser Pro 
        275                 280                 285             


Lys Val Glu Pro Arg Thr Gly Gly Tyr Gly Ser His Ser Glu Val Gln 
    290                 295                 300                 


His Asn Asp Val Ser Glu Gly Lys His Glu His Ser His Ser Lys Gly 
305                 310                 315                 320 


Ser Ser Arg Glu Lys Arg Asn Gly Lys Val Ala Lys Pro Val Leu Leu 
                325                 330                 335     


His Gln Ser Ser Thr Glu Val Ser Ser Thr Asn Gln Val Glu Val Pro 
            340                 345                 350         


Asp Thr Thr Gln Ser Ser Pro Val Ser Ile Ser Ser Gly Leu Asn Ser 
        355                 360                 365             


Asp Pro Asp Met Val Asp Ser Pro Val Val Thr Gly Val Ser Gly Met 
    370                 375                 380                 


Ala Val Ala Ser Val Met Gly Ser Leu Ser Gln Ser Ala Thr Val Phe 
385                 390                 395                 400 


Met Ser Glu Val Thr Asn Glu Ala Val Tyr Thr Met Ser Pro Thr Ala 
                405                 410                 415     


Gly Pro Asn His His Leu Leu Ser Pro Asp Ala Ser Gln Gly Leu Val 
            420                 425                 430         


Leu Ala Val Ser Ser Asp Gly His Lys Phe Ala Phe Pro Thr Thr Gly 
        435                 440                 445             


Ser Ser Glu Ser Leu Ser Met Leu Pro Thr Asn Val Ser Glu Glu Leu 
    450                 455                 460                 


Val Leu Ser Thr Thr Leu Asp Gly Gly Arg Lys Ile Pro Glu Thr Thr 
465                 470                 475                 480 


Met Asn Phe Asp Pro Asp Cys Phe Leu Asn Asn Pro Lys Gln Gly Gln 
                485                 490                 495     


Thr Tyr Gly Gly Gly Gly Leu Lys Ala Glu Met Val Ser Ser Asn Ile 
            500                 505                 510         


Arg His Ser Pro Pro Gly Glu Arg Ser Phe Ser Phe Thr Thr Val Leu 
        515                 520                 525             


Thr Lys Glu Ile Lys Thr Glu Asp Thr Ser Phe Glu Gln Gln Met Ala 
    530                 535                 540                 


Lys Glu Ala Tyr Ser Ser Ser Ala Ala Ala Val Ala Ala Ser Ser Leu 
545                 550                 555                 560 


Thr Leu Thr Ala Gly Ser Ser Leu Leu Pro Ser Gly Gly Gly Leu Ser 
                565                 570                 575     


Pro Ser Thr Thr Leu Glu Gln Met Asp Phe Ser Ala Ile Asp Ser Asn 
            580                 585                 590         


Lys Asp Tyr Thr Ser Ser Phe Ser Gln Thr Gly His Ser Pro His Ile 
        595                 600                 605             


His Gln Thr Pro Ser Pro Ser Phe Phe Leu Gln Asp Ala Ser Lys Pro 
    610                 615                 620                 


Leu Pro Val Glu Gln Asn Thr His Ser Ser Leu Ser Asp Ser Gly Gly 
625                 630                 635                 640 


Thr Phe Val Met Pro Thr Val Lys Thr Glu Ala Ser Ser Gln Thr Ser 
                645                 650                 655     


Ser Cys Ser Gly His Val Glu Thr Arg Ile Glu Ser Thr Ser Ser Leu 
            660                 665                 670         


His Leu Met Gln Phe Gln Ala Asn Phe Gln Ala Met Thr Ala Glu Gly 
        675                 680                 685             


Glu Val Thr Met Glu Thr Ser Gln Ala Ala Glu Gly Ser Glu Val Leu 
    690                 695                 700                 


Leu Lys Ser Gly Glu Leu Gln Ala Cys Ser Ser Glu His Tyr Leu Gln 
705                 710                 715                 720 


Pro Glu Thr Asn Gly Val Ile Arg Ser Ala Gly Gly Val Pro Ile Leu 
                725                 730                 735     


Pro Gly Asn Val Val Gln Gly Leu Tyr Pro Val Ala Gln Pro Ser Leu 
            740                 745                 750         


Gly Asn Ala Ser Asn Met Glu Leu Ser Leu Asp His Phe Asp Ile Ser 
        755                 760                 765             


Phe Ser Asn Gln Phe Ser Asp Leu Ile Asn Asp Phe Ile Ser Val Glu 
    770                 775                 780                 


Gly Gly Ser Ser Thr Ile Tyr Gly His Gln Leu Val Ser Gly Asp Ser 
785                 790                 795                 800 


Thr Ala Leu Ser Gln Ser Glu Asp Gly Ala Arg Ala Pro Phe Thr Gln 
                805                 810                 815     


Ala Glu Met Cys Leu Pro Cys Cys Ser Pro Gln Gln Gly Ser Leu Gln 
            820                 825                 830         


Leu Ser Ser Ser Glu Gly Gly Ala Ser Thr Met Ala Tyr Met His Val 
        835                 840                 845             


Ala Glu Val Val Ser Ala Ala Ser Ala Gln Gly Thr Leu Gly Met Leu 
    850                 855                 860                 


Gln Gln Ser Gly Arg Val Phe Met Val Thr Asp Tyr Ser Pro Glu Trp 
865                 870                 875                 880 


Ser Tyr Pro Glu Gly Gly Val Lys Val Leu Ile Thr Gly Pro Trp Gln 
                885                 890                 895     


Glu Ala Ser Asn Asn Tyr Ser Cys Leu Phe Asp Gln Ile Ser Val Pro 
            900                 905                 910         


Ala Ser Leu Ile Gln Pro Gly Val Leu Arg Cys Tyr Cys Pro Ala His 
        915                 920                 925             


Asp Thr Gly Leu Val Thr Leu Gln Val Ala Phe Asn Asn Gln Ile Ile 
    930                 935                 940                 


Ser Asn Ser Val Val Phe Glu Tyr Lys Ala Arg Ala Leu Pro Thr Leu 
945                 950                 955                 960 


Pro Ser Ser Gln His Asp Trp Leu Ser Leu Asp Asp Asn Gln Phe Arg 
                965                 970                 975     


Met Ser Ile Leu Glu Arg Leu Glu Gln Met Glu Arg Arg Met Ala Glu 
            980                 985                 990         


Met Thr Gly Ser Gln Gln His Lys  Gln Ala Ser Gly Gly  Gly Ser Ser 
        995                 1000                 1005             


Gly Gly  Gly Ser Gly Ser Gly  Asn Gly Gly Ser Gln  Ala Gln Cys 
    1010                 1015                 1020             


Ala Ser  Gly Thr Gly Ala Leu  Gly Ser Cys Phe Glu  Ser Arg Val 
    1025                 1030                 1035             


Val Val  Val Cys Glu Lys Met  Met Ser Arg Ala Cys  Trp Ala Lys 
    1040                 1045                 1050             


Ser Lys  His Leu Ile His Ser  Lys Thr Phe Arg Gly  Met Thr Leu 
    1055                 1060                 1065             


Leu His  Leu Ala Ala Ala Gln  Gly Tyr Ala Thr Leu  Ile Gln Thr 
    1070                 1075                 1080             


Leu Ile  Lys Trp Arg Thr Lys  His Ala Asp Ser Ile  Asp Leu Glu 
    1085                 1090                 1095             


Leu Glu  Val Asp Pro Leu Asn  Val Asp His Phe Ser  Cys Thr Pro 
    1100                 1105                 1110             


Leu Met  Trp Ala Cys Ala Leu  Gly His Leu Glu Ala  Ala Val Val 
    1115                 1120                 1125             


Leu Tyr  Lys Trp Asp Arg Arg  Ala Ile Ser Ile Pro  Asp Ser Leu 
    1130                 1135                 1140             


Gly Arg  Leu Pro Leu Gly Ile  Ala Arg Ser Arg Gly  His Val Lys 
    1145                 1150                 1155             


Leu Ala  Glu Cys Leu Glu His  Leu Gln Arg Asp Glu  Gln Ala Gln 
    1160                 1165                 1170             


Leu Gly  Gln Asn Pro Arg Ile  His Cys Pro Ala Ser  Glu Glu Pro 
    1175                 1180                 1185             


Ser Thr  Glu Ser Trp Met Ala  Gln Trp His Ser Glu  Ala Ile Ser 
    1190                 1195                 1200             


Ser Pro  Glu Ile Pro Lys Gly  Val Thr Val Ile Ala  Ser Thr Asn 
    1205                 1210                 1215             


Pro Glu  Leu Arg Arg Pro Arg  Ser Glu Pro Ser Asn  Tyr Tyr Ser 
    1220                 1225                 1230             


Ser Glu  Ser His Lys Asp Tyr  Pro Ala Pro Lys Lys  His Lys Leu 
    1235                 1240                 1245             


Asn Pro  Glu Tyr Phe Gln Thr  Arg Gln Glu Lys Leu  Leu Pro Thr 
    1250                 1255                 1260             


Ala Leu  Ser Leu Glu Glu Pro  Asn Ile Arg Lys Gln  Ser Pro Ser 
    1265                 1270                 1275             


Ser Lys  Gln Ser Val Pro Glu  Thr Leu Ser Pro Ser  Glu Gly Val 
    1280                 1285                 1290             


Arg Asp  Phe Ser Arg Glu Leu  Ser Pro Pro Thr Pro  Glu Thr Ala 
    1295                 1300                 1305             


Ala Phe  Gln Ala Ser Gly Ser  Gln Pro Val Gly Lys  Trp Asn Ser 
    1310                 1315                 1320             


Lys Asp  Leu Tyr Ile Gly Val  Ser Thr Val Gln Val  Thr Gly Asn 
    1325                 1330                 1335             


Pro Lys  Gly Thr Ser Val Gly  Lys Glu Ala Ala Pro  Ser Gln Val 
    1340                 1345                 1350             


Arg Pro  Arg Glu Pro Met Ser  Val Leu Met Met Ala  Asn Arg Glu 
    1355                 1360                 1365             


Val Val  Asn Thr Glu Leu Gly  Ser Tyr Arg Asp Ser  Ala Glu Asn 
    1370                 1375                 1380             


Glu Glu  Cys Gly Gln Pro Met  Asp Asp Ile Gln Val  Asn Met Met 
    1385                 1390                 1395             


Thr Leu  Ala Glu His Ile Ile  Glu Ala Thr Pro Asp  Arg Ile Lys 
    1400                 1405                 1410             


Gln Glu  Asn Phe Val Pro Met  Glu Ser Ser Gly Leu  Glu Arg Thr 
    1415                 1420                 1425             


Asp Pro  Ala Thr Ile Ser Ser  Thr Met Ser Trp Leu  Ala Ser Tyr 
    1430                 1435                 1440             


Leu Ala  Asp Ala Asp Cys Leu  Pro Ser Ala Ala Gln  Ile Arg Ser 
    1445                 1450                 1455             


Ala Tyr  Asn Glu Pro Leu Thr  Pro Ser Ser Asn Thr  Ser Leu Ser 
    1460                 1465                 1470             


Pro Val  Gly Ser Pro Val Ser  Glu Ile Ala Phe Glu  Lys Pro Asn 
    1475                 1480                 1485             


Leu Pro  Ser Ala Ala Asp Trp  Ser Glu Phe Leu Ser  Ala Ser Thr 
    1490                 1495                 1500             


Ser Glu  Lys Val Glu Asn Glu  Phe Ala Gln Leu Thr  Leu Ser Asp 
    1505                 1510                 1515             


His Glu  Gln Arg Glu Leu Tyr  Glu Ala Ala Arg Leu  Val Gln Thr 
    1520                 1525                 1530             


Ala Phe  Arg Lys Tyr Lys Gly  Arg Pro Leu Arg Glu  Gln Gln Glu 
    1535                 1540                 1545             


Val Ala  Ala Ala Val Ile Gln  Arg Cys Tyr Arg Lys  Tyr Lys Gln 
    1550                 1555                 1560             


Tyr Ala  Leu Tyr Lys Lys Met  Thr Gln Ala Ala Ile  Leu Ile Gln 
    1565                 1570                 1575             


Ser Lys  Phe Arg Ser Tyr Tyr  Glu Gln Lys Lys Phe  Gln Gln Ser 
    1580                 1585                 1590             


Arg Arg  Ala Ala Val Leu Ile  Gln Lys Tyr Tyr Arg  Ser Tyr Lys 
    1595                 1600                 1605             


Lys Cys  Gly Lys Arg Arg Gln  Ala Arg Arg Thr Ala  Val Ile Val 
    1610                 1615                 1620             


Gln Gln  Lys Leu Arg Ser Ser  Leu Leu Thr Lys Lys  Gln Asp Gln 
    1625                 1630                 1635             


Ala Ala  Arg Lys Ile Met Arg  Phe Leu Arg Arg Cys  Arg His Ser 
    1640                 1645                 1650             


Pro Leu  Val Asp His Arg Leu  Tyr Lys Arg Ser Glu  Arg Ile Glu 
    1655                 1660                 1665             


Lys Gly  Gln Gly Thr 
    1670             


<210> 229
<211> 632
<212> PRT
<213> Homo sapiens

<400> 229
Met Glu Glu Leu Val Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Ala Phe Val Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg 
        35                  40                  45              


Phe Pro Pro Pro Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Glu Lys Glu Pro Cys Cys Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Ile Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Ile Glu Arg Leu 
            100                 105                 110         


Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp Thr Phe His Lys 
        115                 120                 125             


Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met Cys Ala Lys Glu 
    130                 135                 140                 


Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Phe Ser Val Thr 
145                 150                 155                 160 


Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser Ile Asn Glu Val 
                165                 170                 175     


Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His Phe Arg Ser Leu 
            180                 185                 190         


Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu Ala Ser Lys Gln 
        195                 200                 205             


Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His Glu Gln Phe Ile 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ala Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Asp Leu Asp 
                245                 250                 255     


Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp Gln Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp Val Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Leu Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Ala 
305                 310                 315                 320 


Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile Met Pro Pro Asn 
                325                 330                 335     


Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn Ala Pro Glu Glu 
            340                 345                 350         


Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His Phe Ser Gln Pro 
        355                 360                 365             


Asn Ser Thr Lys Val Gln Arg Val Leu Val Ala Ser Ser Val Val Ala 
    370                 375                 380                 


Gly Glu Ser Gln Lys Pro Glu Leu Lys Ala Trp Gln Gly Met Val Pro 
385                 390                 395                 400 


Phe Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn Ala Thr Val Leu 
                405                 410                 415     


Leu Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp Gln Leu Arg Leu 
            420                 425                 430         


Glu Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ala Ser Ser 
        435                 440                 445             


Arg Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser Tyr Val Thr Asp 
    450                 455                 460                 


Asp Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr Arg Asn Arg Gly 
465                 470                 475                 480 


His Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr Asn Ser Glu Ala 
                485                 490                 495     


Ser Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp Glu Leu Ser Asp 
            500                 505                 510         


Trp Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser Phe Leu Arg Arg 
        515                 520                 525             


Gly Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly Gln Gly Gly Arg 
    530                 535                 540                 


Gly Arg Gly Gly Gly Phe Lys Gly Asn Asp Asp His Ser Arg Thr Asp 
545                 550                 555                 560 


Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly Arg Thr Thr Asp Gly 
                565                 570                 575     


Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu Arg Ser Val His Thr 
            580                 585                 590         


Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser Arg Leu Arg Thr Gly 
        595                 600                 605             


Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp Ser Val Asp Gly Gln 
    610                 615                 620                 


Gln Pro Leu Val Asn Gly Val Pro 
625                 630         


<210> 230
<211> 2335
<212> PRT
<213> Homo sapiens

<400> 230
Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Lys Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asp Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Val Gly Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Met Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Ala Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Pro His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Leu Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu Asn 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ala  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Gly Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210> 231
<211> 1906
<212> PRT
<213> Homo sapiens

<400> 231
Met Gln Ser Phe Arg Glu Arg Cys Gly Phe His Gly Lys Gln Gln Asn 
1               5                   10                  15      


Tyr Gln Gln Thr Ser Gln Glu Thr Ser Arg Leu Glu Asn Tyr Arg Gln 
            20                  25                  30          


Pro Ser Gln Ala Gly Leu Ser Cys Asp Arg Gln Arg Leu Leu Ala Lys 
        35                  40                  45              


Asp Tyr Tyr Asn Pro Gln Pro Tyr Pro Ser Tyr Glu Gly Gly Ala Gly 
    50                  55                  60                  


Thr Pro Ser Gly Thr Ala Ala Ala Val Ala Ala Asp Lys Tyr His Arg 
65                  70                  75                  80  


Gly Ser Lys Ala Leu Pro Thr Gln Gln Gly Leu Gln Gly Arg Pro Ala 
                85                  90                  95      


Phe Pro Gly Tyr Gly Val Gln Asp Ser Ser Pro Tyr Pro Gly Arg Tyr 
            100                 105                 110         


Ala Gly Glu Glu Ser Leu Gln Ala Trp Gly Ala Pro Gln Pro Pro Pro 
        115                 120                 125             


Pro Gln Pro Gln Pro Leu Pro Ala Gly Val Ala Lys Tyr Asp Glu Asn 
    130                 135                 140                 


Leu Met Lys Lys Thr Ala Val Pro Pro Ser Arg Gln Tyr Ala Glu Gln 
145                 150                 155                 160 


Gly Ala Gln Val Pro Phe Arg Thr His Ser Leu His Val Gln Gln Pro 
                165                 170                 175     


Pro Pro Pro Gln Gln Pro Leu Ala Tyr Pro Lys Leu Gln Arg Gln Lys 
            180                 185                 190         


Leu Gln Asn Asp Ile Ala Ser Pro Leu Pro Phe Pro Gln Gly Thr His 
        195                 200                 205             


Phe Pro Gln His Ser Gln Ser Phe Pro Thr Ser Ser Thr Tyr Ser Ser 
    210                 215                 220                 


Ser Val Gln Gly Gly Gly Gln Gly Ala His Ser Tyr Lys Ser Cys Thr 
225                 230                 235                 240 


Ala Pro Thr Ala Gln Pro His Asp Arg Pro Leu Thr Ala Ser Ser Ser 
                245                 250                 255     


Leu Ala Pro Gly Gln Arg Val Gln Asn Leu His Ala Tyr Gln Ser Gly 
            260                 265                 270         


Arg Leu Ser Tyr Asp Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


Gln Gln Gln Ala Leu Gln Ser Arg His His Ala Gln Glu Thr Leu His 
    290                 295                 300                 


Tyr Gln Asn Leu Ala Lys Tyr Gln His Tyr Gly Gln Gln Gly Gln Gly 
305                 310                 315                 320 


Tyr Cys Gln Pro Asp Ala Ala Val Arg Thr Pro Glu Gln Tyr Tyr Gln 
                325                 330                 335     


Thr Phe Ser Pro Ser Ser Ser His Ser Pro Ala Arg Ser Val Gly Arg 
            340                 345                 350         


Ser Pro Ser Tyr Ser Ser Thr Pro Ser Pro Leu Met Pro Asn Leu Glu 
        355                 360                 365             


Asn Phe Pro Tyr Ser Gln Gln Pro Leu Ser Thr Gly Ala Phe Pro Ala 
    370                 375                 380                 


Gly Ile Thr Asp His Ser His Phe Met Pro Leu Leu Asn Pro Ser Pro 
385                 390                 395                 400 


Thr Asp Ala Thr Ser Ser Val Asp Thr Gln Ala Gly Asn Cys Lys Pro 
                405                 410                 415     


Leu Gln Lys Asp Lys Leu Pro Glu Asn Leu Leu Ser Asp Leu Ser Leu 
            420                 425                 430         


Gln Ser Leu Thr Ala Leu Thr Ser Gln Val Glu Asn Ile Ser Asn Thr 
        435                 440                 445             


Val Gln Gln Leu Leu Leu Ser Lys Ala Ala Val Pro Gln Lys Lys Gly 
    450                 455                 460                 


Val Lys Asn Leu Val Ser Arg Thr Pro Glu Gln His Lys Ser Gln His 
465                 470                 475                 480 


Cys Ser Pro Glu Gly Ser Gly Tyr Ser Ala Glu Pro Ala Gly Thr Pro 
                485                 490                 495     


Leu Ser Glu Pro Pro Ser Ser Thr Pro Gln Ser Thr His Ala Glu Pro 
            500                 505                 510         


Gln Glu Ala Asp Tyr Leu Ser Gly Ser Glu Asp Pro Leu Glu Arg Ser 
        515                 520                 525             


Phe Leu Tyr Cys Asn Gln Ala Arg Gly Ser Pro Ala Arg Val Asn Ser 
    530                 535                 540                 


Asn Ser Lys Ala Lys Pro Glu Ser Val Ser Thr Cys Ser Val Thr Ser 
545                 550                 555                 560 


Pro Asp Asp Met Ser Thr Lys Ser Asp Asp Ser Phe Gln Ser Leu His 
                565                 570                 575     


Gly Ser Leu Pro Leu Asp Ser Phe Ser Lys Phe Val Ala Gly Glu Arg 
            580                 585                 590         


Asp Cys Pro Arg Leu Leu Leu Ser Ala Leu Ala Gln Glu Asp Leu Ala 
        595                 600                 605             


Ser Glu Ile Leu Gly Leu Gln Glu Ala Ile Gly Glu Lys Ala Asp Lys 
    610                 615                 620                 


Ala Trp Ala Glu Ala Pro Ser Leu Val Lys Asp Ser Ser Lys Pro Pro 
625                 630                 635                 640 


Phe Ser Leu Glu Asn His Ser Ala Cys Leu Asp Ser Val Ala Lys Ser 
                645                 650                 655     


Ala Trp Pro Arg Pro Gly Glu Pro Glu Ala Leu Pro Asp Ser Leu Gln 
            660                 665                 670         


Leu Asp Lys Gly Gly Asn Ala Lys Asp Phe Ser Pro Gly Leu Phe Glu 
        675                 680                 685             


Asp Pro Ser Val Ala Phe Ala Thr Pro Asp Pro Lys Lys Thr Thr Gly 
    690                 695                 700                 


Pro Leu Ser Phe Gly Thr Lys Pro Thr Leu Gly Val Pro Ala Pro Asp 
705                 710                 715                 720 


Pro Thr Thr Ala Ala Phe Asp Cys Phe Pro Asp Thr Thr Ala Ala Ser 
                725                 730                 735     


Ser Ala Asp Ser Ala Asn Pro Phe Ala Trp Pro Glu Glu Asn Leu Gly 
            740                 745                 750         


Asp Ala Cys Pro Arg Trp Gly Leu His Pro Gly Glu Leu Thr Lys Gly 
        755                 760                 765             


Leu Glu Gln Gly Gly Lys Ala Ser Asp Gly Ile Ser Lys Gly Asp Thr 
    770                 775                 780                 


His Glu Ala Ser Ala Cys Leu Gly Phe Gln Glu Glu Asp Pro Pro Gly 
785                 790                 795                 800 


Glu Lys Val Ala Ser Leu Pro Gly Asp Phe Lys Gln Glu Glu Val Gly 
                805                 810                 815     


Gly Val Lys Glu Glu Ala Gly Gly Leu Leu Gln Cys Pro Glu Val Ala 
            820                 825                 830         


Lys Ala Asp Arg Trp Leu Glu Asp Ser Arg His Cys Cys Ser Thr Ala 
        835                 840                 845             


Asp Phe Gly Asp Leu Pro Leu Leu Pro Pro Thr Ser Arg Lys Glu Asp 
    850                 855                 860                 


Leu Glu Ala Glu Glu Glu Tyr Ser Ser Leu Cys Glu Leu Leu Gly Ser 
865                 870                 875                 880 


Pro Glu Gln Arg Pro Gly Met Gln Asp Pro Leu Ser Pro Lys Ala Pro 
                885                 890                 895     


Leu Ile Cys Thr Lys Glu Glu Val Glu Glu Val Leu Asp Ser Lys Ala 
            900                 905                 910         


Gly Trp Gly Ser Pro Cys His Leu Ser Gly Glu Ser Val Ile Leu Leu 
        915                 920                 925             


Gly Pro Thr Val Gly Thr Glu Ser Lys Val Gln Ser Trp Phe Glu Ser 
    930                 935                 940                 


Ser Leu Ser His Met Lys Pro Gly Glu Glu Gly Pro Asp Gly Glu Arg 
945                 950                 955                 960 


Ala Pro Gly Asp Ser Thr Thr Ser Asp Ala Ser Leu Ala Gln Lys Pro 
                965                 970                 975     


Asn Lys Pro Ala Val Pro Glu Ala Pro Ile Ala Lys Lys Glu Pro Val 
            980                 985                 990         


Pro Arg Gly Lys Ser Leu Arg Ser  Arg Arg Val His Arg  Gly Leu Pro 
        995                 1000                 1005             


Glu Ala  Glu Asp Ser Pro Cys  Arg Ala Pro Val Leu  Pro Lys Asp 
    1010                 1015                 1020             


Leu Leu  Leu Pro Glu Ser Cys  Thr Gly Pro Pro Gln  Gly Gln Met 
    1025                 1030                 1035             


Glu Gly  Ala Gly Ala Pro Gly  Arg Gly Ala Ser Glu  Gly Leu Pro 
    1040                 1045                 1050             


Arg Met  Cys Thr Arg Ser Leu  Thr Ala Leu Ser Glu  Pro Arg Thr 
    1055                 1060                 1065             


Pro Gly  Pro Pro Gly Leu Thr  Thr Thr Pro Ala Pro  Pro Asp Lys 
    1070                 1075                 1080             


Leu Gly  Gly Lys Gln Arg Ala  Ala Phe Lys Ser Gly  Lys Arg Val 
    1085                 1090                 1095             


Gly Lys  Pro Ser Pro Lys Ala  Ala Ser Ser Pro Ser  Asn Pro Ala 
    1100                 1105                 1110             


Ala Leu  Pro Val Ala Ser Asp  Ser Ser Pro Met Gly  Ser Lys Thr 
    1115                 1120                 1125             


Lys Glu  Thr Asp Ser Pro Ser  Thr Pro Gly Lys Asp  Gln Arg Ser 
    1130                 1135                 1140             


Met Ile  Leu Arg Ser Arg Thr  Lys Thr Gln Glu Ile  Phe His Ser 
    1145                 1150                 1155             


Lys Arg  Arg Arg Pro Ser Glu  Gly Arg Leu Pro Asn  Cys Arg Ala 
    1160                 1165                 1170             


Thr Lys  Lys Leu Leu Asp Asn  Ser His Leu Pro Ala  Thr Phe Lys 
    1175                 1180                 1185             


Val Ser  Ser Ser Pro Gln Lys  Glu Gly Arg Val Ser  Gln Arg Ala 
    1190                 1195                 1200             


Arg Val  Pro Lys Pro Gly Ala  Gly Ser Lys Leu Ser  Asp Arg Pro 
    1205                 1210                 1215             


Leu His  Ala Leu Lys Arg Lys  Ser Ala Phe Met Ala  Pro Val Pro 
    1220                 1225                 1230             


Thr Lys  Lys Arg Asn Leu Val  Leu Arg Ser Arg Ser  Ser Ser Ser 
    1235                 1240                 1245             


Ser Asn  Ala Ser Gly Asn Gly  Gly Asp Gly Lys Glu  Glu Arg Pro 
    1250                 1255                 1260             


Glu Gly  Ser Pro Thr Leu Phe  Lys Arg Met Ser Ser  Pro Lys Lys 
    1265                 1270                 1275             


Ala Lys  Pro Thr Lys Gly Asn  Gly Glu Pro Ala Thr  Lys Leu Pro 
    1280                 1285                 1290             


Pro Pro  Glu Thr Pro Asp Ala  Cys Leu Lys Leu Ala  Ser Arg Ala 
    1295                 1300                 1305             


Ala Phe  Gln Gly Ala Met Lys  Thr Lys Val Leu Pro  Pro Arg Lys 
    1310                 1315                 1320             


Gly Arg  Gly Leu Lys Leu Glu  Ala Ile Val Gln Lys  Ile Thr Ser 
    1325                 1330                 1335             


Pro Ser  Leu Lys Lys Phe Ala  Cys Lys Ala Pro Gly  Ala Ser Pro 
    1340                 1345                 1350             


Gly Asn  Pro Leu Ser Pro Ser  Leu Ser Asp Lys Asp  Arg Gly Leu 
    1355                 1360                 1365             


Lys Gly  Ala Gly Gly Ser Pro  Val Gly Val Glu Glu  Gly Leu Val 
    1370                 1375                 1380             


Asn Val  Gly Thr Gly Gln Lys  Leu Pro Thr Ser Gly  Ala Asp Pro 
    1385                 1390                 1395             


Leu Cys  Arg Asn Pro Thr Asn  Arg Ser Leu Lys Gly  Lys Leu Met 
    1400                 1405                 1410             


Asn Ser  Lys Lys Leu Ser Ser  Thr Asp Cys Phe Lys  Thr Glu Ala 
    1415                 1420                 1425             


Phe Thr  Ser Pro Glu Ala Leu  Gln Pro Gly Gly Thr  Ala Leu Ala 
    1430                 1435                 1440             


Pro Lys  Lys Arg Ser Arg Lys  Gly Arg Ala Gly Ala  His Gly Leu 
    1445                 1450                 1455             


Ser Lys  Gly Pro Leu Glu Lys  Arg Pro Tyr Leu Gly  Pro Ala Leu 
    1460                 1465                 1470             


Leu Leu  Thr Pro Arg Asp Arg  Ala Ser Gly Thr Gln  Gly Ala Ser 
    1475                 1480                 1485             


Glu Asp  Asn Ser Gly Gly Gly  Gly Lys Lys Pro Lys  Met Glu Glu 
    1490                 1495                 1500             


Leu Gly  Leu Ala Ser Gln Pro  Pro Glu Gly Arg Pro  Cys Gln Pro 
    1505                 1510                 1515             


Gln Thr  Arg Ala Gln Lys Gln  Pro Gly His Thr Asn  Tyr Ser Ser 
    1520                 1525                 1530             


Tyr Ser  Lys Arg Lys Arg Leu  Thr Arg Gly Arg Ala  Lys Asn Thr 
    1535                 1540                 1545             


Thr Ser  Ser Pro Cys Lys Gly  Arg Ala Lys Arg Arg  Arg Gln Gln 
    1550                 1555                 1560             


Gln Val  Leu Pro Leu Asp Pro  Ala Glu Pro Glu Ile  Arg Leu Lys 
    1565                 1570                 1575             


Tyr Ile  Ser Ser Cys Lys Arg  Leu Arg Ser Asp Ser  Arg Thr Pro 
    1580                 1585                 1590             


Ala Phe  Ser Pro Phe Val Arg  Val Glu Lys Arg Asp  Ala Phe Thr 
    1595                 1600                 1605             


Thr Ile  Cys Thr Val Val Asn  Ser Pro Gly Asp Ala  Pro Lys Pro 
    1610                 1615                 1620             


His Arg  Lys Pro Ser Ser Ser  Ala Ser Ser Ser Ser  Ser Ser Ser 
    1625                 1630                 1635             


Ser Phe  Ser Leu Asp Ala Ala  Gly Ala Ser Leu Ala  Thr Leu Pro 
    1640                 1645                 1650             


Gly Gly  Ser Ile Leu Gln Pro  Arg Pro Ser Leu Pro  Leu Ser Ser 
    1655                 1660                 1665             


Thr Met  His Leu Gly Pro Val  Val Ser Lys Ala Leu  Ser Thr Ser 
    1670                 1675                 1680             


Cys Leu  Val Cys Cys Leu Cys  Gln Asn Pro Ala Asn  Phe Lys Asp 
    1685                 1690                 1695             


Leu Gly  Asp Leu Cys Gly Pro  Tyr Tyr Pro Glu His  Cys Leu Pro 
    1700                 1705                 1710             


Lys Lys  Lys Pro Lys Leu Lys  Glu Lys Val Arg Pro  Glu Gly Thr 
    1715                 1720                 1725             


Cys Glu  Glu Ala Ser Leu Pro  Leu Glu Arg Thr Leu  Lys Gly Pro 
    1730                 1735                 1740             


Glu Cys  Ala Ala Ala Ala Thr  Ala Gly Lys Pro Pro  Arg Pro Asp 
    1745                 1750                 1755             


Gly Pro  Ala Asp Pro Ala Lys  Gln Gly Pro Leu Arg  Thr Ser Ala 
    1760                 1765                 1770             


Arg Gly  Leu Ser Arg Arg Leu  Gln Ser Cys Tyr Cys  Cys Asp Gly 
    1775                 1780                 1785             


Arg Glu  Asp Gly Gly Glu Glu  Ala Ala Pro Ala Asp  Lys Gly Arg 
    1790                 1795                 1800             


Lys His  Glu Cys Ser Lys Glu  Ala Pro Ala Glu Pro  Gly Gly Glu 
    1805                 1810                 1815             


Ala Gln  Glu His Trp Val His  Glu Ala Cys Ala Val  Trp Thr Gly 
    1820                 1825                 1830             


Gly Val  Tyr Leu Val Ala Gly  Lys Leu Phe Gly Leu  Gln Glu Ala 
    1835                 1840                 1845             


Met Lys  Val Ala Val Asp Met  Met Cys Ser Ser Cys  Gln Glu Ala 
    1850                 1855                 1860             


Gly Ala  Thr Ile Gly Cys Cys  His Lys Gly Cys Leu  His Thr Tyr 
    1865                 1870                 1875             


His Tyr  Pro Cys Ala Ser Asp  Ala Gly Cys Ile Phe  Ile Glu Glu 
    1880                 1885                 1890             


Asn Phe  Ser Leu Lys Cys Pro  Lys His Lys Arg Leu  Pro 
    1895                 1900                 1905     


<210> 232
<211> 2442
<212> PRT
<213> Homo sapiens

<400> 232
Met Ala Glu Asn Leu Leu Asp Gly Pro Pro Asn Pro Lys Arg Ala Lys 
1               5                   10                  15      


Leu Ser Ser Pro Gly Phe Ser Ala Asn Asp Ser Thr Asp Phe Gly Ser 
            20                  25                  30          


Leu Phe Asp Leu Glu Asn Asp Leu Pro Asp Glu Leu Ile Pro Asn Gly 
        35                  40                  45              


Gly Glu Leu Gly Leu Leu Asn Ser Gly Asn Leu Val Pro Asp Ala Ala 
    50                  55                  60                  


Ser Lys His Lys Gln Leu Ser Glu Leu Leu Arg Gly Gly Ser Gly Ser 
65                  70                  75                  80  


Ser Ile Asn Pro Gly Ile Gly Asn Val Ser Ala Ser Ser Pro Val Gln 
                85                  90                  95      


Gln Gly Leu Gly Gly Gln Ala Gln Gly Gln Pro Asn Ser Ala Asn Met 
            100                 105                 110         


Ala Ser Leu Ser Ala Met Gly Lys Ser Pro Leu Ser Gln Gly Asp Ser 
        115                 120                 125             


Ser Ala Pro Ser Leu Pro Lys Gln Ala Ala Ser Thr Ser Gly Pro Thr 
    130                 135                 140                 


Pro Ala Ala Ser Gln Ala Leu Asn Pro Gln Ala Gln Lys Gln Val Gly 
145                 150                 155                 160 


Leu Ala Thr Ser Ser Pro Ala Thr Ser Gln Thr Gly Pro Gly Ile Cys 
                165                 170                 175     


Met Asn Ala Asn Phe Asn Gln Thr His Pro Gly Leu Leu Asn Ser Asn 
            180                 185                 190         


Ser Gly His Ser Leu Ile Asn Gln Ala Ser Gln Gly Gln Ala Gln Val 
        195                 200                 205             


Met Asn Gly Ser Leu Gly Ala Ala Gly Arg Gly Arg Gly Ala Gly Met 
    210                 215                 220                 


Pro Tyr Pro Thr Pro Ala Met Gln Gly Ala Ser Ser Ser Val Leu Ala 
225                 230                 235                 240 


Glu Thr Leu Thr Gln Val Ser Pro Gln Met Thr Gly His Ala Gly Leu 
                245                 250                 255     


Asn Thr Ala Gln Ala Gly Gly Met Ala Lys Met Gly Ile Thr Gly Asn 
            260                 265                 270         


Thr Ser Pro Phe Gly Gln Pro Phe Ser Gln Ala Gly Gly Gln Pro Met 
        275                 280                 285             


Gly Ala Thr Gly Val Asn Pro Gln Leu Ala Ser Lys Gln Ser Met Val 
    290                 295                 300                 


Asn Ser Leu Pro Thr Phe Pro Thr Asp Ile Lys Asn Thr Ser Val Thr 
305                 310                 315                 320 


Asn Val Pro Asn Met Ser Gln Met Gln Thr Ser Val Gly Ile Val Pro 
                325                 330                 335     


Thr Gln Ala Ile Ala Thr Gly Pro Thr Ala Asp Pro Glu Lys Arg Lys 
            340                 345                 350         


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
        355                 360                 365             


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Ala Cys Ser Leu Pro His 
    370                 375                 380                 


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ala 
385                 390                 395                 400 


Gly Lys Ala Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
                405                 410                 415     


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
            420                 425                 430         


Leu Lys Asn Ala Ser Asp Lys Arg Asn Gln Gln Thr Ile Leu Gly Ser 
        435                 440                 445             


Pro Ala Ser Gly Ile Gln Asn Thr Ile Gly Ser Val Gly Thr Gly Gln 
    450                 455                 460                 


Gln Asn Ala Thr Ser Leu Ser Asn Pro Asn Pro Ile Asp Pro Ser Ser 
465                 470                 475                 480 


Met Gln Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Met Asn Gln Pro 
                485                 490                 495     


Gln Thr Gln Leu Gln Pro Gln Val Pro Gly Gln Gln Pro Ala Gln Pro 
            500                 505                 510         


Gln Thr His Gln Gln Met Arg Thr Leu Asn Pro Leu Gly Asn Asn Pro 
        515                 520                 525             


Met Asn Ile Pro Ala Gly Gly Ile Thr Thr Asp Gln Gln Pro Pro Asn 
    530                 535                 540                 


Leu Ile Ser Glu Ser Ala Leu Pro Thr Ser Leu Gly Ala Thr Asn Pro 
545                 550                 555                 560 


Leu Met Asn Asp Gly Ser Asn Ser Gly Asn Ile Gly Thr Leu Ser Thr 
                565                 570                 575     


Ile Pro Thr Ala Ala Pro Pro Ser Ser Thr Gly Val Arg Lys Gly Trp 
            580                 585                 590         


His Glu His Val Thr Gln Asp Leu Arg Ser His Leu Val His Lys Leu 
        595                 600                 605             


Val Gln Ala Ile Phe Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg 
    610                 615                 620                 


Arg Met Glu Asn Leu Val Ala Tyr Ala Lys Lys Val Glu Gly Asp Met 
625                 630                 635                 640 


Tyr Glu Ser Ala Asn Ser Arg Asp Glu Tyr Tyr His Leu Leu Ala Glu 
                645                 650                 655     


Lys Ile Tyr Lys Ile Gln Lys Glu Leu Glu Glu Lys Arg Arg Ser Arg 
            660                 665                 670         


Leu His Lys Gln Gly Ile Leu Gly Asn Gln Pro Ala Leu Pro Ala Pro 
        675                 680                 685             


Gly Ala Gln Pro Pro Val Ile Pro Gln Ala Gln Pro Val Arg Pro Pro 
    690                 695                 700                 


Asn Gly Pro Leu Ser Leu Pro Val Asn Arg Met Gln Val Ser Gln Gly 
705                 710                 715                 720 


Met Asn Ser Phe Asn Pro Met Ser Leu Gly Asn Val Gln Leu Pro Gln 
                725                 730                 735     


Ala Pro Met Gly Pro Arg Ala Ala Ser Pro Met Asn His Ser Val Gln 
            740                 745                 750         


Met Asn Ser Met Gly Ser Val Pro Gly Met Ala Ile Ser Pro Ser Arg 
        755                 760                 765             


Met Pro Gln Pro Pro Asn Met Met Gly Ala His Thr Asn Asn Met Met 
    770                 775                 780                 


Ala Gln Ala Pro Ala Gln Ser Gln Phe Leu Pro Gln Asn Gln Phe Pro 
785                 790                 795                 800 


Ser Ser Ser Gly Ala Met Ser Val Gly Met Gly Gln Pro Pro Ala Gln 
                805                 810                 815     


Thr Gly Val Ser Gln Gly Gln Val Pro Gly Ala Ala Leu Pro Asn Pro 
            820                 825                 830         


Leu Asn Met Leu Gly Pro Gln Ala Ser Gln Leu Pro Cys Pro Pro Val 
        835                 840                 845             


Thr Gln Ser Pro Leu His Pro Thr Pro Pro Pro Ala Ser Thr Ala Ala 
    850                 855                 860                 


Gly Met Pro Ser Leu Gln His Thr Thr Pro Pro Gly Met Thr Pro Pro 
865                 870                 875                 880 


Gln Pro Ala Ala Pro Thr Gln Pro Ser Thr Pro Val Ser Ser Ser Gly 
                885                 890                 895     


Gln Thr Pro Thr Pro Thr Pro Gly Ser Val Pro Ser Ala Thr Gln Thr 
            900                 905                 910         


Gln Ser Thr Pro Thr Val Gln Ala Ala Ala Gln Ala Gln Val Thr Pro 
        915                 920                 925             


Gln Pro Gln Thr Pro Val Gln Pro Pro Ser Val Ala Thr Pro Gln Ser 
    930                 935                 940                 


Ser Gln Gln Gln Pro Thr Pro Val His Ala Gln Pro Pro Gly Thr Pro 
945                 950                 955                 960 


Leu Ser Gln Ala Ala Ala Ser Ile Asp Asn Arg Val Pro Thr Pro Ser 
                965                 970                 975     


Ser Val Ala Ser Ala Glu Thr Asn Ser Gln Gln Pro Gly Pro Asp Val 
            980                 985                 990         


Pro Val Leu Glu Met Lys Thr Glu  Thr Gln Ala Glu Asp  Thr Glu Pro 
        995                 1000                 1005             


Asp Pro  Gly Glu Ser Lys Gly  Glu Pro Arg Ser Glu  Met Met Glu 
    1010                 1015                 1020             


Glu Asp  Leu Gln Gly Ala Ser  Gln Val Lys Glu Glu  Thr Asp Ile 
    1025                 1030                 1035             


Ala Glu  Gln Lys Ser Glu Pro  Met Glu Val Asp Glu  Lys Lys Pro 
    1040                 1045                 1050             


Glu Val  Lys Val Glu Val Lys  Glu Glu Glu Glu Ser  Ser Ser Asn 
    1055                 1060                 1065             


Gly Thr  Ala Ser Gln Ser Thr  Ser Pro Ser Gln Pro  Arg Lys Lys 
    1070                 1075                 1080             


Ile Phe  Lys Pro Glu Glu Leu  Arg Gln Ala Leu Met  Pro Thr Leu 
    1085                 1090                 1095             


Glu Ala  Leu Tyr Arg Gln Asp  Pro Glu Ser Leu Pro  Phe Arg Gln 
    1100                 1105                 1110             


Pro Val  Asp Pro Gln Leu Leu  Gly Ile Pro Asp Tyr  Phe Asp Ile 
    1115                 1120                 1125             


Val Lys  Asn Pro Met Asp Leu  Ser Thr Ile Lys Arg  Lys Leu Asp 
    1130                 1135                 1140             


Thr Gly  Gln Tyr Gln Glu Pro  Trp Gln Tyr Val Asp  Asp Val Trp 
    1145                 1150                 1155             


Leu Met  Phe Asn Asn Ala Trp  Leu Tyr Asn Arg Lys  Thr Ser Arg 
    1160                 1165                 1170             


Val Tyr  Lys Phe Cys Ser Lys  Leu Ala Glu Val Phe  Glu Gln Glu 
    1175                 1180                 1185             


Ile Asp  Pro Val Met Gln Ser  Leu Gly Tyr Cys Cys  Gly Arg Lys 
    1190                 1195                 1200             


Tyr Glu  Phe Ser Pro Gln Thr  Leu Cys Cys Tyr Gly  Lys Gln Leu 
    1205                 1210                 1215             


Cys Thr  Ile Pro Arg Asp Ala  Ala Tyr Tyr Ser Tyr  Gln Asn Arg 
    1220                 1225                 1230             


Tyr His  Phe Cys Glu Lys Cys  Phe Thr Glu Ile Gln  Gly Glu Asn 
    1235                 1240                 1245             


Val Thr  Leu Gly Asp Asp Pro  Ser Gln Pro Gln Thr  Thr Ile Ser 
    1250                 1255                 1260             


Lys Asp  Gln Phe Glu Lys Lys  Lys Asn Asp Thr Leu  Asp Pro Glu 
    1265                 1270                 1275             


Pro Phe  Val Asp Cys Lys Glu  Cys Gly Arg Lys Met  His Gln Ile 
    1280                 1285                 1290             


Cys Val  Leu His Tyr Asp Ile  Ile Trp Pro Ser Gly  Phe Val Cys 
    1295                 1300                 1305             


Asp Asn  Cys Leu Lys Lys Thr  Gly Arg Pro Arg Lys  Glu Asn Lys 
    1310                 1315                 1320             


Phe Ser  Ala Lys Arg Leu Gln  Thr Thr Arg Leu Gly  Asn His Leu 
    1325                 1330                 1335             


Glu Asp  Arg Val Asn Lys Phe  Leu Arg Arg Gln Asn  His Pro Glu 
    1340                 1345                 1350             


Ala Gly  Glu Val Phe Val Arg  Val Val Ala Ser Ser  Asp Lys Thr 
    1355                 1360                 1365             


Val Glu  Val Lys Pro Gly Met  Lys Ser Arg Phe Val  Asp Ser Gly 
    1370                 1375                 1380             


Glu Met  Ser Glu Ser Phe Pro  Tyr Arg Thr Lys Ala  Leu Phe Ala 
    1385                 1390                 1395             


Phe Glu  Glu Ile Asp Gly Val  Asp Val Cys Phe Phe  Gly Met His 
    1400                 1405                 1410             


Val Gln  Glu Tyr Gly Ser Asp  Cys Pro Pro Pro Asn  Thr Arg Arg 
    1415                 1420                 1425             


Val Tyr  Ile Ser Tyr Leu Asp  Ser Ile His Phe Phe  Arg Pro Arg 
    1430                 1435                 1440             


Cys Leu  Arg Thr Ala Val Tyr  His Glu Ile Leu Ile  Gly Tyr Leu 
    1445                 1450                 1455             


Glu Tyr  Val Lys Lys Leu Gly  Tyr Val Thr Gly His  Ile Trp Ala 
    1460                 1465                 1470             


Cys Pro  Pro Ser Glu Gly Asp  Asp Tyr Ile Phe His  Cys His Pro 
    1475                 1480                 1485             


Pro Asp  Gln Lys Ile Pro Lys  Pro Lys Arg Leu Gln  Glu Trp Tyr 
    1490                 1495                 1500             


Lys Lys  Met Leu Asp Lys Ala  Phe Ala Glu Arg Ile  Ile His Asp 
    1505                 1510                 1515             


Tyr Lys  Asp Ile Phe Lys Gln  Ala Thr Glu Asp Arg  Leu Thr Ser 
    1520                 1525                 1530             


Ala Lys  Glu Leu Pro Tyr Phe  Glu Gly Asp Phe Trp  Pro Asn Val 
    1535                 1540                 1545             


Leu Glu  Glu Ser Ile Lys Glu  Leu Glu Gln Glu Glu  Glu Glu Arg 
    1550                 1555                 1560             


Lys Lys  Glu Glu Ser Thr Ala  Ala Ser Glu Thr Thr  Glu Gly Ser 
    1565                 1570                 1575             


Gln Gly  Asp Ser Lys Asn Ala  Lys Lys Lys Asn Asn  Lys Lys Thr 
    1580                 1585                 1590             


Asn Lys  Asn Lys Ser Ser Ile  Ser Arg Ala Asn Lys  Lys Lys Pro 
    1595                 1600                 1605             


Ser Met  Pro Asn Val Ser Asn  Asp Leu Ser Gln Lys  Leu Tyr Ala 
    1610                 1615                 1620             


Thr Met  Glu Lys His Lys Glu  Val Phe Phe Val Ile  His Leu His 
    1625                 1630                 1635             


Ala Gly  Pro Val Ile Asn Thr  Leu Pro Pro Ile Val  Asp Pro Asp 
    1640                 1645                 1650             


Pro Leu  Leu Ser Cys Asp Leu  Met Asp Gly Arg Asp  Ala Phe Leu 
    1655                 1660                 1665             


Thr Leu  Ala Arg Asp Lys His  Trp Glu Phe Ser Ser  Leu Arg Arg 
    1670                 1675                 1680             


Ser Lys  Trp Ser Thr Leu Cys  Met Leu Val Glu Leu  His Thr Gln 
    1685                 1690                 1695             


Gly Gln  Asp Arg Phe Val Tyr  Thr Cys Asn Glu Cys  Lys His His 
    1700                 1705                 1710             


Val Glu  Thr Arg Trp His Cys  Thr Val Cys Glu Asp  Tyr Asp Leu 
    1715                 1720                 1725             


Cys Ile  Asn Cys Tyr Asn Thr  Lys Ser His Ala His  Lys Met Val 
    1730                 1735                 1740             


Lys Trp  Gly Leu Gly Leu Asp  Asp Glu Gly Ser Ser  Gln Gly Glu 
    1745                 1750                 1755             


Pro Gln  Ser Lys Ser Pro Gln  Glu Ser Arg Arg Leu  Ser Ile Gln 
    1760                 1765                 1770             


Arg Cys  Ile Gln Ser Leu Val  His Ala Cys Gln Cys  Arg Asn Ala 
    1775                 1780                 1785             


Asn Cys  Ser Leu Pro Ser Cys  Gln Lys Met Lys Arg  Val Val Gln 
    1790                 1795                 1800             


His Thr  Lys Gly Cys Lys Arg  Lys Thr Asn Gly Gly  Cys Pro Val 
    1805                 1810                 1815             


Cys Lys  Gln Leu Ile Ala Leu  Cys Cys Tyr His Ala  Lys His Cys 
    1820                 1825                 1830             


Gln Glu  Asn Lys Cys Pro Val  Pro Phe Cys Leu Asn  Ile Lys His 
    1835                 1840                 1845             


Lys Leu  Arg Gln Gln Gln Ile  Gln His Arg Leu Gln  Gln Ala Gln 
    1850                 1855                 1860             


Leu Met  Arg Arg Arg Met Ala  Thr Met Asn Thr Arg  Asn Val Pro 
    1865                 1870                 1875             


Gln Gln  Ser Leu Pro Ser Pro  Thr Ser Ala Pro Pro  Gly Thr Pro 
    1880                 1885                 1890             


Thr Gln  Gln Pro Ser Thr Pro  Gln Thr Pro Gln Pro  Pro Ala Gln 
    1895                 1900                 1905             


Pro Gln  Pro Ser Pro Val Ser  Met Ser Pro Ala Gly  Phe Pro Ser 
    1910                 1915                 1920             


Val Ala  Arg Thr Gln Pro Pro  Thr Thr Val Ser Thr  Gly Lys Pro 
    1925                 1930                 1935             


Thr Ser  Gln Val Pro Ala Pro  Pro Pro Pro Ala Gln  Pro Pro Pro 
    1940                 1945                 1950             


Ala Ala  Val Glu Ala Ala Arg  Gln Ile Glu Arg Glu  Ala Gln Gln 
    1955                 1960                 1965             


Gln Gln  His Leu Tyr Arg Val  Asn Ile Asn Asn Ser  Met Pro Pro 
    1970                 1975                 1980             


Gly Arg  Thr Gly Met Gly Thr  Pro Gly Ser Gln Met  Ala Pro Val 
    1985                 1990                 1995             


Ser Leu  Asn Val Pro Arg Pro  Asn Gln Val Ser Gly  Pro Val Met 
    2000                 2005                 2010             


Pro Ser  Met Pro Pro Gly Gln  Trp Gln Gln Ala Pro  Leu Pro Gln 
    2015                 2020                 2025             


Gln Gln  Pro Met Pro Gly Leu  Pro Arg Pro Val Ile  Ser Met Gln 
    2030                 2035                 2040             


Ala Gln  Ala Ala Val Ala Gly  Pro Arg Met Pro Ser  Val Gln Pro 
    2045                 2050                 2055             


Pro Arg  Ser Ile Ser Pro Ser  Ala Leu Gln Asp Leu  Leu Arg Thr 
    2060                 2065                 2070             


Leu Lys  Ser Pro Ser Ser Pro  Gln Gln Gln Gln Gln  Val Leu Asn 
    2075                 2080                 2085             


Ile Leu  Lys Ser Asn Pro Gln  Leu Met Ala Ala Phe  Ile Lys Gln 
    2090                 2095                 2100             


Arg Thr  Ala Lys Tyr Val Ala  Asn Gln Pro Gly Met  Gln Pro Gln 
    2105                 2110                 2115             


Pro Gly  Leu Gln Ser Gln Pro  Gly Met Gln Pro Gln  Pro Gly Met 
    2120                 2125                 2130             


His Gln  Gln Pro Ser Leu Gln  Asn Leu Asn Ala Met  Gln Ala Gly 
    2135                 2140                 2145             


Val Pro  Arg Pro Gly Val Pro  Pro Gln Gln Gln Ala  Met Gly Gly 
    2150                 2155                 2160             


Leu Asn  Pro Gln Gly Gln Ala  Leu Asn Ile Met Asn  Pro Gly His 
    2165                 2170                 2175             


Asn Pro  Asn Met Ala Ser Met  Asn Pro Gln Tyr Arg  Glu Met Leu 
    2180                 2185                 2190             


Arg Arg  Gln Leu Leu Gln Gln  Gln Gln Gln Gln Gln  Gln Gln Gln 
    2195                 2200                 2205             


Gln Gln  Gln Gln Gln Gln Gln  Gln Gly Ser Ala Gly  Met Ala Gly 
    2210                 2215                 2220             


Gly Met  Ala Gly His Gly Gln  Phe Gln Gln Pro Gln  Gly Pro Gly 
    2225                 2230                 2235             


Gly Tyr  Pro Pro Ala Met Gln  Gln Gln Gln Arg Met  Gln Gln His 
    2240                 2245                 2250             


Leu Pro  Leu Gln Gly Ser Ser  Met Gly Gln Met Ala  Ala Gln Met 
    2255                 2260                 2265             


Gly Gln  Leu Gly Gln Met Gly  Gln Pro Gly Leu Gly  Ala Asp Ser 
    2270                 2275                 2280             


Thr Pro  Asn Ile Gln Gln Ala  Leu Gln Gln Arg Ile  Leu Gln Gln 
    2285                 2290                 2295             


Gln Gln  Met Lys Gln Gln Ile  Gly Ser Pro Gly Gln  Pro Asn Pro 
    2300                 2305                 2310             


Met Ser  Pro Gln Gln His Met  Leu Ser Gly Gln Pro  Gln Ala Ser 
    2315                 2320                 2325             


His Leu  Pro Gly Gln Gln Ile  Ala Thr Ser Leu Ser  Asn Gln Val 
    2330                 2335                 2340             


Arg Ser  Pro Ala Pro Val Gln  Ser Pro Arg Pro Gln  Ser Gln Pro 
    2345                 2350                 2355             


Pro His  Ser Ser Pro Ser Pro  Arg Ile Gln Pro Gln  Pro Ser Pro 
    2360                 2365                 2370             


His His  Val Ser Pro Gln Thr  Gly Ser Pro His Pro  Gly Leu Ala 
    2375                 2380                 2385             


Val Thr  Met Ala Ser Ser Ile  Asp Gln Gly His Leu  Gly Asn Pro 
    2390                 2395                 2400             


Glu Gln  Ser Ala Met Leu Pro  Gln Leu Asn Thr Pro  Ser Arg Ser 
    2405                 2410                 2415             


Ala Leu  Ser Ser Glu Leu Ser  Leu Val Gly Asp Thr  Thr Gly Asp 
    2420                 2425                 2430             


Thr Leu  Glu Lys Phe Val Glu  Gly Leu 
    2435                 2440         


<210> 233
<211> 2839
<212> PRT
<213> Homo sapiens

<400> 233
Met Ala Ala His Arg Pro Val Glu Trp Val Gln Ala Val Val Ser Arg 
1               5                   10                  15      


Phe Asp Glu Gln Leu Pro Ile Lys Thr Gly Gln Gln Asn Thr His Thr 
            20                  25                  30          


Lys Val Ser Thr Glu His Asn Lys Glu Cys Leu Ile Asn Ile Ser Lys 
        35                  40                  45              


Tyr Lys Phe Ser Leu Val Ile Ser Gly Leu Thr Thr Ile Leu Lys Asn 
    50                  55                  60                  


Val Asn Asn Met Arg Ile Phe Gly Glu Ala Ala Glu Lys Asn Leu Tyr 
65                  70                  75                  80  


Leu Ser Gln Leu Ile Ile Leu Asp Thr Leu Glu Lys Cys Leu Ala Gly 
                85                  90                  95      


Gln Pro Lys Asp Thr Met Arg Leu Asp Glu Thr Met Leu Val Lys Gln 
            100                 105                 110         


Leu Leu Pro Glu Ile Cys His Phe Leu His Thr Cys Arg Glu Gly Asn 
        115                 120                 125             


Gln His Ala Ala Glu Leu Arg Asn Ser Ala Ser Gly Val Leu Phe Ser 
    130                 135                 140                 


Leu Ser Cys Asn Asn Phe Asn Ala Val Phe Ser Arg Ile Ser Thr Arg 
145                 150                 155                 160 


Leu Gln Glu Leu Thr Val Cys Ser Glu Asp Asn Val Asp Val His Asp 
                165                 170                 175     


Ile Glu Leu Leu Gln Tyr Ile Asn Val Asp Cys Ala Lys Leu Lys Arg 
            180                 185                 190         


Leu Leu Lys Glu Thr Ala Phe Lys Phe Lys Ala Leu Lys Lys Val Ala 
        195                 200                 205             


Gln Leu Ala Val Ile Asn Ser Leu Glu Lys Ala Phe Trp Asn Trp Val 
    210                 215                 220                 


Glu Asn Tyr Pro Asp Glu Phe Thr Lys Leu Tyr Gln Ile Pro Gln Thr 
225                 230                 235                 240 


Asp Met Ala Glu Cys Ala Glu Lys Leu Phe Asp Leu Val Asp Gly Phe 
                245                 250                 255     


Ala Glu Ser Thr Lys Arg Lys Ala Ala Val Trp Pro Leu Gln Ile Ile 
            260                 265                 270         


Leu Leu Ile Leu Cys Pro Glu Ile Ile Gln Asp Ile Ser Lys Asp Val 
        275                 280                 285             


Val Asp Glu Asn Asn Met Asn Lys Lys Leu Phe Leu Asp Ser Leu Arg 
    290                 295                 300                 


Lys Ala Leu Ala Gly His Gly Gly Ser Arg Gln Leu Thr Glu Ser Ala 
305                 310                 315                 320 


Ala Ile Ala Cys Val Lys Leu Cys Lys Ala Ser Thr Tyr Ile Asn Trp 
                325                 330                 335     


Glu Asp Asn Ser Val Ile Phe Leu Leu Val Gln Ser Met Val Val Asp 
            340                 345                 350         


Leu Lys Asn Leu Leu Phe Asn Pro Ser Lys Pro Phe Ser Arg Gly Ser 
        355                 360                 365             


Gln Pro Ala Asp Val Asp Leu Met Ile Asp Cys Leu Val Ser Cys Phe 
    370                 375                 380                 


Arg Ile Ser Pro His Asn Asn Gln His Phe Lys Ile Cys Leu Ala Gln 
385                 390                 395                 400 


Asn Ser Pro Ser Thr Phe His Tyr Val Leu Val Asn Ser Leu His Arg 
                405                 410                 415     


Ile Ile Thr Asn Ser Ala Leu Asp Trp Trp Pro Lys Ile Asp Ala Val 
            420                 425                 430         


Tyr Cys His Ser Val Glu Leu Arg Asn Met Phe Gly Glu Thr Leu His 
        435                 440                 445             


Lys Ala Val Gln Gly Cys Gly Ala His Pro Ala Ile Arg Met Ala Pro 
    450                 455                 460                 


Ser Leu Thr Phe Lys Glu Lys Val Thr Ser Leu Lys Phe Lys Glu Lys 
465                 470                 475                 480 


Pro Thr Asp Leu Glu Thr Arg Ser Tyr Lys Tyr Leu Leu Leu Ser Met 
                485                 490                 495     


Val Lys Leu Ile His Ala Asp Pro Lys Leu Leu Leu Cys Asn Pro Arg 
            500                 505                 510         


Lys Gln Gly Pro Glu Thr Gln Gly Ser Thr Ala Glu Leu Ile Thr Gly 
        515                 520                 525             


Leu Val Gln Leu Val Pro Gln Ser His Met Pro Glu Ile Ala Gln Glu 
    530                 535                 540                 


Ala Met Glu Ala Leu Leu Val Leu His Gln Leu Asp Ser Ile Asp Leu 
545                 550                 555                 560 


Trp Asn Pro Asp Ala Pro Val Glu Thr Phe Trp Glu Ile Ser Ser Gln 
                565                 570                 575     


Met Leu Phe Tyr Ile Cys Lys Lys Leu Thr Ser His Gln Met Leu Ser 
            580                 585                 590         


Ser Thr Glu Ile Leu Lys Trp Leu Arg Glu Ile Leu Ile Cys Arg Asn 
        595                 600                 605             


Lys Phe Leu Leu Lys Asn Lys Gln Ala Asp Arg Ser Ser Cys His Phe 
    610                 615                 620                 


Leu Leu Phe Tyr Gly Val Gly Cys Asp Ile Pro Ser Ser Gly Asn Thr 
625                 630                 635                 640 


Ser Gln Met Ser Met Asp His Glu Glu Leu Leu Arg Thr Pro Gly Ala 
                645                 650                 655     


Ser Leu Arg Lys Gly Lys Gly Asn Ser Ser Met Asp Ser Ala Ala Gly 
            660                 665                 670         


Cys Ser Gly Thr Pro Pro Ile Cys Arg Gln Ala Gln Thr Lys Leu Glu 
        675                 680                 685             


Val Ala Leu Tyr Met Phe Leu Trp Asn Pro Asp Thr Glu Ala Val Leu 
    690                 695                 700                 


Val Ala Met Ser Cys Phe Arg His Leu Cys Glu Glu Ala Asp Ile Arg 
705                 710                 715                 720 


Cys Gly Val Asp Glu Val Ser Val His Asn Leu Leu Pro Asn Tyr Asn 
                725                 730                 735     


Thr Phe Met Glu Phe Ala Ser Val Ser Asn Met Met Ser Thr Gly Arg 
            740                 745                 750         


Ala Ala Leu Gln Lys Arg Val Met Ala Leu Leu Arg Arg Ile Glu His 
        755                 760                 765             


Pro Thr Ala Gly Asn Thr Glu Ala Trp Glu Asp Thr His Ala Lys Trp 
    770                 775                 780                 


Glu Gln Ala Thr Lys Leu Ile Leu Asn Tyr Pro Lys Ala Lys Met Glu 
785                 790                 795                 800 


Asp Gly Gln Ala Ala Glu Ser Leu His Lys Thr Ile Val Lys Arg Arg 
                805                 810                 815     


Met Ser His Val Ser Gly Gly Gly Ser Ile Asp Leu Ser Asp Thr Asp 
            820                 825                 830         


Ser Leu Gln Glu Trp Ile Asn Met Thr Gly Phe Leu Cys Ala Leu Gly 
        835                 840                 845             


Gly Val Cys Leu Gln Gln Arg Ser Asn Ser Gly Leu Ala Thr Tyr Ser 
    850                 855                 860                 


Pro Pro Met Gly Pro Val Ser Glu Arg Lys Gly Ser Met Ile Ser Val 
865                 870                 875                 880 


Met Ser Ser Glu Gly Asn Ala Asp Thr Pro Val Ser Lys Phe Met Asp 
                885                 890                 895     


Arg Leu Leu Ser Leu Met Val Cys Asn His Glu Lys Val Gly Leu Gln 
            900                 905                 910         


Ile Arg Thr Asn Val Lys Asp Leu Val Gly Leu Glu Leu Ser Pro Ala 
        915                 920                 925             


Leu Tyr Pro Met Leu Phe Asn Lys Leu Lys Asn Thr Ile Ser Lys Phe 
    930                 935                 940                 


Phe Asp Ser Gln Gly Gln Val Leu Leu Thr Asp Thr Asn Thr Gln Phe 
945                 950                 955                 960 


Val Glu Gln Thr Ile Ala Ile Met Lys Asn Leu Leu Asp Asn His Thr 
                965                 970                 975     


Glu Gly Ser Ser Glu His Leu Gly Gln Ala Ser Ile Glu Thr Met Met 
            980                 985                 990         


Leu Asn Leu Val Arg Tyr Val Arg  Val Leu Gly Asn Met  Val His Ala 
        995                 1000                 1005             


Ile Gln  Ile Lys Thr Lys Leu  Cys Gln Leu Val Glu  Val Met Met 
    1010                 1015                 1020             


Ala Arg  Arg Asp Asp Leu Ser  Phe Cys Gln Glu Met  Lys Phe Arg 
    1025                 1030                 1035             


Asn Lys  Met Val Glu Tyr Leu  Thr Asp Trp Val Met  Gly Thr Ser 
    1040                 1045                 1050             


Asn Gln  Ala Ala Asp Asp Asp  Val Lys Cys Leu Thr  Arg Asp Leu 
    1055                 1060                 1065             


Asp Gln  Ala Ser Met Glu Ala  Val Val Ser Leu Leu  Ala Gly Leu 
    1070                 1075                 1080             


Pro Leu  Gln Pro Glu Glu Gly  Asp Gly Val Glu Leu  Met Glu Ala 
    1085                 1090                 1095             


Lys Ser  Gln Leu Phe Leu Lys  Tyr Phe Thr Leu Phe  Met Asn Leu 
    1100                 1105                 1110             


Leu Asn  Asp Cys Ser Glu Val  Glu Asp Glu Ser Ala  Gln Thr Gly 
    1115                 1120                 1125             


Gly Arg  Lys Arg Gly Met Ser  Arg Arg Leu Ala Ser  Leu Arg His 
    1130                 1135                 1140             


Cys Thr  Val Leu Ala Met Ser  Asn Leu Leu Asn Ala  Asn Val Asp 
    1145                 1150                 1155             


Ser Gly  Leu Met His Ser Ile  Gly Leu Gly Tyr His  Lys Asp Leu 
    1160                 1165                 1170             


Gln Thr  Arg Ala Thr Phe Met  Glu Val Leu Thr Lys  Ile Leu Gln 
    1175                 1180                 1185             


Gln Gly  Thr Glu Phe Asp Thr  Leu Ala Glu Thr Val  Leu Ala Asp 
    1190                 1195                 1200             


Arg Phe  Glu Arg Leu Val Glu  Leu Val Thr Met Met  Gly Asp Gln 
    1205                 1210                 1215             


Gly Glu  Leu Pro Ile Ala Met  Ala Leu Ala Asn Val  Val Pro Cys 
    1220                 1225                 1230             


Ser Gln  Trp Asp Glu Leu Ala  Arg Val Leu Val Thr  Leu Phe Asp 
    1235                 1240                 1245             


Ser Arg  His Leu Leu Tyr Gln  Leu Leu Trp Asn Met  Phe Ser Lys 
    1250                 1255                 1260             


Glu Val  Glu Leu Ala Asp Ser  Met Gln Thr Leu Phe  Arg Gly Asn 
    1265                 1270                 1275             


Ser Leu  Ala Ser Lys Ile Met  Thr Phe Cys Phe Lys  Val Tyr Gly 
    1280                 1285                 1290             


Ala Thr  Tyr Leu Gln Lys Leu  Leu Asp Pro Leu Leu  Arg Ile Val 
    1295                 1300                 1305             


Ile Thr  Ser Ser Asp Trp Gln  His Val Ser Phe Glu  Val Asp Pro 
    1310                 1315                 1320             


Thr Arg  Leu Glu Pro Ser Glu  Ser Leu Glu Glu Asn  Gln Arg Asn 
    1325                 1330                 1335             


Leu Leu  Gln Met Thr Glu Lys  Phe Phe His Ala Ile  Ile Ser Ser 
    1340                 1345                 1350             


Ser Ser  Glu Phe Pro Pro Gln  Leu Arg Ser Val Cys  His Cys Leu 
    1355                 1360                 1365             


Tyr Gln  Ala Thr Cys His Ser  Leu Leu Asn Lys Ala  Thr Val Lys 
    1370                 1375                 1380             


Glu Lys  Lys Glu Asn Lys Lys  Ser Val Val Ser Gln  Arg Phe Pro 
    1385                 1390                 1395             


Gln Asn  Ser Ile Gly Ala Val  Gly Ser Ala Met Phe  Leu Arg Phe 
    1400                 1405                 1410             


Ile Asn  Pro Ala Ile Val Ser  Pro Tyr Glu Ala Gly  Ile Leu Asp 
    1415                 1420                 1425             


Lys Lys  Pro Pro Pro Arg Ile  Glu Arg Gly Leu Lys  Leu Met Ser 
    1430                 1435                 1440             


Lys Ile  Leu Gln Ser Ile Ala  Asn His Val Leu Phe  Thr Lys Glu 
    1445                 1450                 1455             


Glu His  Met Arg Pro Phe Asn  Asp Phe Val Lys Ser  Asn Phe Asp 
    1460                 1465                 1470             


Ala Ala  Arg Arg Phe Phe Leu  Asp Ile Ala Ser Asp  Cys Pro Thr 
    1475                 1480                 1485             


Ser Asp  Ala Val Asn His Ser  Leu Ser Phe Ile Ser  Asp Gly Asn 
    1490                 1495                 1500             


Val Leu  Ala Leu His Arg Leu  Leu Trp Asn Asn Gln  Glu Lys Ile 
    1505                 1510                 1515             


Gly Gln  Tyr Leu Ser Ser Asn  Arg Asp His Lys Ala  Val Gly Arg 
    1520                 1525                 1530             


Arg Pro  Phe Asp Lys Met Ala  Thr Leu Leu Ala Tyr  Leu Gly Pro 
    1535                 1540                 1545             


Pro Glu  His Lys Pro Val Ala  Asp Thr His Trp Ser  Ser Leu Asn 
    1550                 1555                 1560             


Leu Thr  Ser Ser Lys Phe Glu  Glu Phe Met Thr Arg  His Gln Val 
    1565                 1570                 1575             


His Glu  Lys Glu Glu Phe Lys  Ala Leu Lys Thr Leu  Ser Ile Phe 
    1580                 1585                 1590             


Tyr Gln  Ala Gly Thr Ser Lys  Ala Gly Asn Pro Ile  Phe Tyr Tyr 
    1595                 1600                 1605             


Val Ala  Arg Arg Phe Lys Thr  Gly Gln Ile Asn Gly  Asp Leu Leu 
    1610                 1615                 1620             


Ile Tyr  His Val Leu Leu Thr  Leu Lys Pro Tyr Tyr  Ala Lys Pro 
    1625                 1630                 1635             


Tyr Glu  Ile Val Val Asp Leu  Thr His Thr Gly Pro  Ser Asn Arg 
    1640                 1645                 1650             


Phe Lys  Thr Asp Phe Leu Ser  Lys Trp Phe Val Val  Phe Pro Gly 
    1655                 1660                 1665             


Phe Ala  Tyr Asp Asn Val Ser  Ala Val Tyr Ile Tyr  Asn Cys Asn 
    1670                 1675                 1680             


Ser Trp  Val Arg Glu Tyr Thr  Lys Tyr His Glu Arg  Leu Leu Thr 
    1685                 1690                 1695             


Gly Leu  Lys Gly Ser Lys Arg  Leu Val Phe Ile Asp  Cys Pro Gly 
    1700                 1705                 1710             


Lys Leu  Ala Glu His Ile Glu  His Glu Gln Gln Lys  Leu Pro Ala 
    1715                 1720                 1725             


Ala Thr  Leu Ala Leu Glu Glu  Asp Leu Lys Val Phe  His Asn Ala 
    1730                 1735                 1740             


Leu Lys  Leu Ala His Lys Asp  Thr Lys Val Ser Ile  Lys Val Gly 
    1745                 1750                 1755             


Ser Thr  Ala Val Gln Val Thr  Ser Ala Glu Arg Thr  Lys Val Leu 
    1760                 1765                 1770             


Gly Gln  Ser Val Phe Leu Asn  Asp Ile Tyr Tyr Ala  Ser Glu Ile 
    1775                 1780                 1785             


Glu Glu  Ile Cys Leu Val Asp  Glu Asn Gln Phe Thr  Leu Thr Ile 
    1790                 1795                 1800             


Ala Asn  Gln Gly Thr Pro Leu  Thr Phe Met His Gln  Glu Cys Glu 
    1805                 1810                 1815             


Ala Ile  Val Gln Ser Ile Ile  His Ile Arg Thr Arg  Trp Glu Leu 
    1820                 1825                 1830             


Ser Gln  Pro Asp Ser Ile Pro  Gln His Thr Lys Ile  Arg Pro Lys 
    1835                 1840                 1845             


Asp Val  Pro Gly Thr Leu Leu  Asn Ile Ala Leu Leu  Asn Leu Gly 
    1850                 1855                 1860             


Ser Ser  Asp Pro Ser Leu Arg  Ser Ala Ala Tyr Asn  Leu Leu Cys 
    1865                 1870                 1875             


Ala Leu  Thr Cys Thr Phe Asn  Leu Lys Ile Glu Gly  Gln Leu Leu 
    1880                 1885                 1890             


Glu Thr  Ser Gly Leu Cys Ile  Pro Ala Asn Asn Thr  Leu Phe Ile 
    1895                 1900                 1905             


Val Ser  Ile Ser Lys Thr Leu  Ala Ala Asn Glu Pro  His Leu Thr 
    1910                 1915                 1920             


Leu Glu  Phe Leu Glu Glu Cys  Ile Ser Gly Phe Ser  Lys Ser Ser 
    1925                 1930                 1935             


Ile Glu  Leu Lys His Leu Cys  Leu Glu Tyr Met Thr  Pro Trp Leu 
    1940                 1945                 1950             


Ser Asn  Leu Val Arg Phe Cys  Lys His Asn Asp Asp  Ala Lys Arg 
    1955                 1960                 1965             


Gln Arg  Val Thr Ala Ile Leu  Asp Lys Leu Ile Thr  Met Thr Ile 
    1970                 1975                 1980             


Asn Glu  Lys Gln Met Tyr Pro  Ser Ile Gln Ala Lys  Ile Trp Gly 
    1985                 1990                 1995             


Ser Leu  Gly Gln Ile Thr Asp  Leu Leu Asp Val Val  Leu Asp Ser 
    2000                 2005                 2010             


Phe Ile  Lys Thr Ser Ala Thr  Gly Gly Leu Gly Ser  Ile Lys Ala 
    2015                 2020                 2025             


Glu Val  Met Ala Asp Thr Ala  Val Ala Leu Ala Ser  Gly Asn Val 
    2030                 2035                 2040             


Lys Leu  Val Ser Ser Lys Val  Ile Gly Arg Met Cys  Lys Ile Ile 
    2045                 2050                 2055             


Asp Lys  Thr Cys Leu Ser Pro  Thr Pro Thr Leu Glu  Gln His Leu 
    2060                 2065                 2070             


Met Trp  Asp Asp Ile Ala Ile  Leu Ala Arg Tyr Met  Leu Met Leu 
    2075                 2080                 2085             


Ser Phe  Asn Asn Ser Leu Asp  Val Ala Ala His Leu  Pro Tyr Leu 
    2090                 2095                 2100             


Phe His  Val Val Thr Phe Leu  Val Ala Thr Gly Pro  Leu Ser Leu 
    2105                 2110                 2115             


Arg Ala  Ser Thr His Gly Leu  Val Ile Asn Ile Ile  His Ser Leu 
    2120                 2125                 2130             


Cys Thr  Cys Ser Gln Leu His  Phe Ser Glu Glu Thr  Lys Gln Val 
    2135                 2140                 2145             


Leu Arg  Leu Ser Leu Thr Glu  Phe Ser Leu Pro Lys  Phe Tyr Leu 
    2150                 2155                 2160             


Leu Phe  Gly Ile Ser Lys Val  Lys Ser Ala Ala Val  Ile Ala Phe 
    2165                 2170                 2175             


Arg Ser  Ser Tyr Arg Asp Arg  Ser Phe Ser Pro Gly  Ser Tyr Glu 
    2180                 2185                 2190             


Arg Glu  Thr Phe Ala Leu Thr  Ser Leu Glu Thr Val  Thr Glu Ala 
    2195                 2200                 2205             


Leu Leu  Glu Ile Met Glu Ala  Cys Met Arg Asp Ile  Pro Thr Cys 
    2210                 2215                 2220             


Lys Trp  Leu Asp Gln Trp Thr  Glu Leu Ala Gln Arg  Phe Ala Phe 
    2225                 2230                 2235             


Gln Tyr  Asn Pro Ser Leu Gln  Pro Arg Ala Leu Val  Val Phe Gly 
    2240                 2245                 2250             


Cys Ile  Ser Lys Arg Val Ser  His Gly Gln Ile Lys  Gln Ile Ile 
    2255                 2260                 2265             


Arg Ile  Leu Ser Lys Ala Leu  Glu Ser Cys Leu Lys  Gly Pro Asp 
    2270                 2275                 2280             


Thr Tyr  Asn Ser Gln Val Leu  Ile Glu Ala Thr Val  Ile Ala Leu 
    2285                 2290                 2295             


Thr Lys  Leu Gln Pro Leu Leu  Asn Lys Asp Ser Pro  Leu His Lys 
    2300                 2305                 2310             


Ala Leu  Phe Trp Val Ala Val  Ala Val Leu Gln Leu  Asp Glu Val 
    2315                 2320                 2325             


Asn Leu  Tyr Ser Ala Gly Thr  Ala Leu Leu Glu Gln  Asn Leu His 
    2330                 2335                 2340             


Thr Leu  Asp Ser Leu Arg Ile  Phe Asn Asp Lys Ser  Pro Glu Glu 
    2345                 2350                 2355             


Val Phe  Met Ala Ile Arg Asn  Pro Leu Glu Trp His  Cys Lys Gln 
    2360                 2365                 2370             


Met Asp  His Phe Val Gly Leu  Asn Phe Asn Ser Asn  Phe Asn Phe 
    2375                 2380                 2385             


Ala Leu  Val Gly His Leu Leu  Lys Gly Tyr Arg His  Pro Ser Pro 
    2390                 2395                 2400             


Ala Ile  Val Ala Arg Thr Val  Arg Ile Leu His Thr  Leu Leu Thr 
    2405                 2410                 2415             


Leu Val  Asn Lys His Arg Asn  Cys Asp Lys Phe Glu  Val Asn Thr 
    2420                 2425                 2430             


Gln Ser  Val Ala Tyr Leu Ala  Ala Leu Leu Thr Val  Ser Glu Glu 
    2435                 2440                 2445             


Val Arg  Ser Arg Cys Ser Leu  Lys His Arg Lys Ser  Leu Leu Leu 
    2450                 2455                 2460             


Thr Asp  Ile Ser Met Glu Asn  Val Pro Met Asp Thr  Tyr Pro Ile 
    2465                 2470                 2475             


His His  Gly Asp Pro Ser Tyr  Arg Thr Leu Lys Glu  Thr Gln Pro 
    2480                 2485                 2490             


Trp Ser  Ser Pro Lys Gly Ser  Glu Gly Tyr Leu Ala  Ala Thr Tyr 
    2495                 2500                 2505             


Pro Thr  Val Gly Gln Thr Ser  Pro Arg Ala Arg Lys  Ser Met Ser 
    2510                 2515                 2520             


Leu Asp  Met Gly Gln Pro Ser  Gln Ala Asn Thr Lys  Lys Leu Leu 
    2525                 2530                 2535             


Gly Thr  Arg Lys Ser Phe Asp  His Leu Ile Ser Asp  Thr Lys Ala 
    2540                 2545                 2550             


Pro Lys  Arg Gln Glu Met Glu  Ser Gly Ile Thr Thr  Pro Pro Lys 
    2555                 2560                 2565             


Met Arg  Arg Val Ala Glu Thr  Asp Tyr Glu Met Glu  Thr Gln Arg 
    2570                 2575                 2580             


Ile Ser  Ser Ser Gln Gln His  Pro His Leu Arg Lys  Val Ser Val 
    2585                 2590                 2595             


Ser Glu  Ser Asn Val Leu Leu  Asp Glu Glu Val Leu  Thr Asp Pro 
    2600                 2605                 2610             


Lys Ile  Gln Ala Leu Leu Leu  Thr Val Leu Ala Thr  Leu Val Lys 
    2615                 2620                 2625             


Tyr Thr  Thr Asp Glu Phe Asp  Gln Arg Ile Leu Tyr  Glu Tyr Leu 
    2630                 2635                 2640             


Ala Glu  Ala Ser Val Val Phe  Pro Lys Val Phe Pro  Val Val His 
    2645                 2650                 2655             


Asn Leu  Leu Asp Ser Lys Ile  Asn Thr Leu Leu Ser  Leu Cys Gln 
    2660                 2665                 2670             


Asp Pro  Asn Leu Leu Asn Pro  Ile His Gly Ile Val  Gln Ser Val 
    2675                 2680                 2685             


Val Tyr  His Glu Glu Ser Pro  Pro Gln Tyr Gln Thr  Ser Tyr Leu 
    2690                 2695                 2700             


Gln Ser  Phe Gly Phe Asn Gly  Leu Trp Arg Phe Ala  Gly Pro Phe 
    2705                 2710                 2715             


Ser Lys  Gln Thr Gln Ile Pro  Asp Tyr Ala Glu Leu  Ile Val Lys 
    2720                 2725                 2730             


Phe Leu  Asp Ala Leu Ile Asp  Thr Tyr Leu Pro Gly  Ile Asp Glu 
    2735                 2740                 2745             


Glu Thr  Ser Glu Glu Ser Leu  Leu Thr Pro Thr Ser  Pro Tyr Pro 
    2750                 2755                 2760             


Pro Ala  Leu Gln Ser Gln Leu  Ser Ile Thr Ala Asn  Leu Asn Leu 
    2765                 2770                 2775             


Ser Asn  Ser Met Thr Ser Leu  Ala Thr Ser Gln His  Ser Pro Gly 
    2780                 2785                 2790             


Ile Asp  Lys Glu Asn Val Glu  Leu Ser Pro Thr Thr  Gly His Cys 
    2795                 2800                 2805             


Asn Ser  Gly Arg Thr Arg His  Gly Ser Ala Ser Gln  Val Gln Lys 
    2810                 2815                 2820             


Gln Arg  Ser Ala Gly Ser Phe  Lys Arg Asn Ser Ile  Lys Lys Ile 
    2825                 2830                 2835             


Val 
    


<210> 234
<211> 3969
<212> PRT
<213> Homo sapiens

<400> 234
Met Ala His Ser Cys Arg Trp Arg Phe Pro Ala Arg Pro Gly Thr Thr 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Arg Arg Gly Leu Gly Gly Ala Pro Arg 
            20                  25                  30          


Gln Arg Val Pro Ala Leu Leu Leu Pro Pro Gly Pro Pro Val Gly Gly 
        35                  40                  45              


Gly Gly Pro Gly Ala Pro Pro Ser Pro Pro Ala Val Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Gly Ser Ser Gly Ala Gly Val Pro Gly Gly Ala Ala Ala 
65                  70                  75                  80  


Ala Ser Ala Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ser Ser Ser 
                85                  90                  95      


Ser Ser Ala Ser Ser Gly Pro Ala Leu Leu Arg Val Gly Pro Gly Phe 
            100                 105                 110         


Asp Ala Ala Leu Gln Val Ser Ala Ala Ile Gly Thr Asn Leu Arg Arg 
        115                 120                 125             


Phe Arg Ala Val Phe Gly Glu Ser Gly Gly Gly Gly Gly Ser Gly Glu 
    130                 135                 140                 


Asp Glu Gln Phe Leu Gly Phe Gly Ser Asp Glu Glu Val Arg Val Arg 
145                 150                 155                 160 


Ser Pro Thr Arg Ser Pro Ser Val Lys Thr Ser Pro Arg Lys Pro Arg 
                165                 170                 175     


Gly Arg Pro Arg Ser Gly Ser Asp Arg Asn Ser Ala Ile Leu Ser Asp 
            180                 185                 190         


Pro Ser Val Phe Ser Pro Leu Asn Lys Ser Glu Thr Lys Ser Gly Asp 
        195                 200                 205             


Lys Ile Lys Lys Lys Asp Ser Lys Ser Ile Glu Lys Lys Arg Gly Arg 
    210                 215                 220                 


Pro Pro Thr Phe Pro Gly Val Lys Ile Lys Ile Thr His Gly Lys Asp 
225                 230                 235                 240 


Ile Ser Glu Leu Pro Lys Gly Asn Lys Glu Asp Ser Leu Lys Lys Ile 
                245                 250                 255     


Lys Arg Thr Pro Ser Ala Thr Phe Gln Gln Ala Thr Lys Ile Lys Lys 
            260                 265                 270         


Leu Arg Ala Gly Lys Leu Ser Pro Leu Lys Ser Lys Phe Lys Thr Gly 
        275                 280                 285             


Lys Leu Gln Ile Gly Arg Lys Gly Val Gln Ile Val Arg Arg Arg Gly 
    290                 295                 300                 


Arg Pro Pro Ser Thr Glu Arg Ile Lys Thr Pro Ser Gly Leu Leu Ile 
305                 310                 315                 320 


Asn Ser Glu Leu Glu Lys Pro Gln Lys Val Arg Lys Asp Lys Glu Gly 
                325                 330                 335     


Thr Pro Pro Leu Thr Lys Glu Asp Lys Thr Val Val Arg Gln Ser Pro 
            340                 345                 350         


Arg Arg Ile Lys Pro Val Arg Ile Ile Pro Ser Ser Lys Arg Thr Asp 
        355                 360                 365             


Ala Thr Ile Ala Lys Gln Leu Leu Gln Arg Ala Lys Lys Gly Ala Gln 
    370                 375                 380                 


Lys Lys Ile Glu Lys Glu Ala Ala Gln Leu Gln Gly Arg Lys Val Lys 
385                 390                 395                 400 


Thr Gln Val Lys Asn Ile Arg Gln Phe Ile Met Pro Val Val Ser Ala 
                405                 410                 415     


Ile Ser Ser Arg Ile Ile Lys Thr Pro Arg Arg Phe Ile Glu Asp Glu 
            420                 425                 430         


Asp Tyr Asp Pro Pro Ile Lys Ile Ala Arg Leu Glu Ser Thr Pro Asn 
        435                 440                 445             


Ser Arg Phe Ser Ala Pro Ser Cys Gly Ser Ser Glu Lys Ser Ser Ala 
    450                 455                 460                 


Ala Ser Gln His Ser Ser Gln Met Ser Ser Asp Ser Ser Arg Ser Ser 
465                 470                 475                 480 


Ser Pro Ser Val Asp Thr Ser Thr Asp Ser Gln Ala Ser Glu Glu Ile 
                485                 490                 495     


Gln Val Leu Pro Glu Glu Arg Ser Asp Thr Pro Glu Val His Pro Pro 
            500                 505                 510         


Leu Pro Ile Ser Gln Ser Pro Glu Asn Glu Ser Asn Asp Arg Arg Ser 
        515                 520                 525             


Arg Arg Tyr Ser Val Ser Glu Arg Ser Phe Gly Ser Arg Thr Thr Lys 
    530                 535                 540                 


Lys Leu Ser Thr Leu Gln Ser Ala Pro Gln Gln Gln Thr Ser Ser Ser 
545                 550                 555                 560 


Pro Pro Pro Pro Leu Leu Thr Pro Pro Pro Pro Leu Gln Pro Ala Ser 
                565                 570                 575     


Ser Ile Ser Asp His Thr Pro Trp Leu Met Pro Pro Thr Ile Pro Leu 
            580                 585                 590         


Ala Ser Pro Phe Leu Pro Ala Ser Thr Ala Pro Met Gln Gly Lys Arg 
        595                 600                 605             


Lys Ser Ile Leu Arg Glu Pro Thr Phe Arg Trp Thr Ser Leu Lys His 
    610                 615                 620                 


Ser Arg Ser Glu Pro Gln Tyr Phe Ser Ser Ala Lys Tyr Ala Lys Glu 
625                 630                 635                 640 


Gly Leu Ile Arg Lys Pro Ile Phe Asp Asn Phe Arg Pro Pro Pro Leu 
                645                 650                 655     


Thr Pro Glu Asp Val Gly Phe Ala Ser Gly Phe Ser Ala Ser Gly Thr 
            660                 665                 670         


Ala Ala Ser Ala Arg Leu Phe Ser Pro Leu His Ser Gly Thr Arg Phe 
        675                 680                 685             


Asp Met His Lys Arg Ser Pro Leu Leu Arg Ala Pro Arg Phe Thr Pro 
    690                 695                 700                 


Ser Glu Ala His Ser Arg Ile Phe Glu Ser Val Thr Leu Pro Ser Asn 
705                 710                 715                 720 


Arg Thr Ser Ala Gly Thr Ser Ser Ser Gly Val Ser Asn Arg Lys Arg 
                725                 730                 735     


Lys Arg Lys Val Phe Ser Pro Ile Arg Ser Glu Pro Arg Ser Pro Ser 
            740                 745                 750         


His Ser Met Arg Thr Arg Ser Gly Arg Leu Ser Ser Ser Glu Leu Ser 
        755                 760                 765             


Pro Leu Thr Pro Pro Ser Ser Val Ser Ser Ser Leu Ser Ile Ser Val 
    770                 775                 780                 


Ser Pro Leu Ala Thr Ser Ala Leu Asn Pro Thr Phe Thr Phe Pro Ser 
785                 790                 795                 800 


His Ser Leu Thr Gln Ser Gly Glu Ser Ala Glu Lys Asn Gln Arg Pro 
                805                 810                 815     


Arg Lys Gln Thr Ser Ala Pro Ala Glu Pro Phe Ser Ser Ser Ser Pro 
            820                 825                 830         


Thr Pro Leu Phe Pro Trp Phe Thr Pro Gly Ser Gln Thr Glu Arg Gly 
        835                 840                 845             


Arg Asn Lys Asp Lys Ala Pro Glu Glu Leu Ser Lys Asp Arg Asp Ala 
    850                 855                 860                 


Asp Lys Ser Val Glu Lys Asp Lys Ser Arg Glu Arg Asp Arg Glu Arg 
865                 870                 875                 880 


Glu Lys Glu Asn Lys Arg Glu Ser Arg Lys Glu Lys Arg Lys Lys Gly 
                885                 890                 895     


Ser Glu Ile Gln Ser Ser Ser Ala Leu Tyr Pro Val Gly Arg Val Ser 
            900                 905                 910         


Lys Glu Lys Val Val Gly Glu Asp Val Ala Thr Ser Ser Ser Ala Lys 
        915                 920                 925             


Lys Ala Thr Gly Arg Lys Lys Ser Ser Ser His Asp Ser Gly Thr Asp 
    930                 935                 940                 


Ile Thr Ser Val Thr Leu Gly Asp Thr Thr Ala Val Lys Thr Lys Ile 
945                 950                 955                 960 


Leu Ile Lys Lys Gly Arg Gly Asn Leu Glu Lys Thr Asn Leu Asp Leu 
                965                 970                 975     


Gly Pro Thr Ala Pro Ser Leu Glu Lys Glu Lys Thr Leu Cys Leu Ser 
            980                 985                 990         


Thr Pro Ser Ser Ser Thr Val Lys  His Ser Thr Ser Ser  Ile Gly Ser 
        995                 1000                 1005             


Met Leu  Ala Gln Ala Asp Lys  Leu Pro Met Thr Asp  Lys Arg Val 
    1010                 1015                 1020             


Ala Ser  Leu Leu Lys Lys Ala  Lys Ala Gln Leu Cys  Lys Ile Glu 
    1025                 1030                 1035             


Lys Ser  Lys Ser Leu Lys Gln  Thr Asp Gln Pro Lys  Ala Gln Gly 
    1040                 1045                 1050             


Gln Glu  Ser Asp Ser Ser Glu  Thr Ser Val Arg Gly  Pro Arg Ile 
    1055                 1060                 1065             


Lys His  Val Cys Arg Arg Ala  Ala Val Ala Leu Gly  Arg Lys Arg 
    1070                 1075                 1080             


Ala Val  Phe Pro Asp Asp Met  Pro Thr Leu Ser Ala  Leu Pro Trp 
    1085                 1090                 1095             


Glu Glu  Arg Glu Lys Ile Leu  Ser Ser Met Gly Asn  Asp Asp Lys 
    1100                 1105                 1110             


Ser Ser  Ile Ala Gly Ser Glu  Asp Ala Glu Pro Leu  Ala Pro Pro 
    1115                 1120                 1125             


Ile Lys  Pro Ile Lys Pro Val  Thr Arg Asn Lys Ala  Pro Gln Glu 
    1130                 1135                 1140             


Pro Pro  Val Lys Lys Gly Arg  Arg Ser Arg Arg Cys  Gly Gln Cys 
    1145                 1150                 1155             


Pro Gly  Cys Gln Val Pro Glu  Asp Cys Gly Val Cys  Thr Asn Cys 
    1160                 1165                 1170             


Leu Asp  Lys Pro Lys Phe Gly  Gly Arg Asn Ile Lys  Lys Gln Cys 
    1175                 1180                 1185             


Cys Lys  Met Arg Lys Cys Gln  Asn Leu Gln Trp Met  Pro Ser Lys 
    1190                 1195                 1200             


Ala Tyr  Leu Gln Lys Gln Ala  Lys Ala Val Lys Lys  Lys Glu Lys 
    1205                 1210                 1215             


Lys Ser  Lys Thr Ser Glu Lys  Lys Asp Ser Lys Glu  Ser Ser Val 
    1220                 1225                 1230             


Val Lys  Asn Val Val Asp Ser  Ser Gln Lys Pro Thr  Pro Ser Ala 
    1235                 1240                 1245             


Arg Glu  Asp Pro Ala Pro Lys  Lys Ser Ser Ser Glu  Pro Pro Pro 
    1250                 1255                 1260             


Arg Lys  Pro Val Glu Glu Lys  Ser Glu Glu Gly Asn  Val Ser Ala 
    1265                 1270                 1275             


Pro Gly  Pro Glu Ser Lys Gln  Ala Thr Thr Pro Ala  Ser Arg Lys 
    1280                 1285                 1290             


Ser Ser  Lys Gln Val Ser Gln  Pro Ala Leu Val Ile  Pro Pro Gln 
    1295                 1300                 1305             


Pro Pro  Thr Thr Gly Pro Pro  Arg Lys Glu Val Pro  Lys Thr Thr 
    1310                 1315                 1320             


Pro Ser  Glu Pro Lys Lys Lys  Gln Pro Pro Pro Pro  Glu Ser Gly 
    1325                 1330                 1335             


Pro Glu  Gln Ser Lys Gln Lys  Lys Val Ala Pro Arg  Pro Ser Ile 
    1340                 1345                 1350             


Pro Val  Lys Gln Lys Pro Lys  Glu Lys Glu Lys Pro  Pro Pro Val 
    1355                 1360                 1365             


Asn Lys  Gln Glu Asn Ala Gly  Thr Leu Asn Ile Leu  Ser Thr Leu 
    1370                 1375                 1380             


Ser Asn  Gly Asn Ser Ser Lys  Gln Lys Ile Pro Ala  Asp Gly Val 
    1385                 1390                 1395             


His Arg  Ile Arg Val Asp Phe  Lys Glu Asp Cys Glu  Ala Glu Asn 
    1400                 1405                 1410             


Val Trp  Glu Met Gly Gly Leu  Gly Ile Leu Thr Ser  Val Pro Ile 
    1415                 1420                 1425             


Thr Pro  Arg Val Val Cys Phe  Leu Cys Ala Ser Ser  Gly His Val 
    1430                 1435                 1440             


Glu Phe  Val Tyr Cys Gln Val  Cys Cys Glu Pro Phe  His Lys Phe 
    1445                 1450                 1455             


Cys Leu  Glu Glu Asn Glu Arg  Pro Leu Glu Asp Gln  Leu Glu Asn 
    1460                 1465                 1470             


Trp Cys  Cys Arg Arg Cys Lys  Phe Cys His Val Cys  Gly Arg Gln 
    1475                 1480                 1485             


His Gln  Ala Thr Lys Gln Leu  Leu Glu Cys Asn Lys  Cys Arg Asn 
    1490                 1495                 1500             


Ser Tyr  His Pro Glu Cys Leu  Gly Pro Asn Tyr Pro  Thr Lys Pro 
    1505                 1510                 1515             


Thr Lys  Lys Lys Lys Val Trp  Ile Cys Thr Lys Cys  Val Arg Cys 
    1520                 1525                 1530             


Lys Ser  Cys Gly Ser Thr Thr  Pro Gly Lys Gly Trp  Asp Ala Gln 
    1535                 1540                 1545             


Trp Ser  His Asp Phe Ser Leu  Cys His Asp Cys Ala  Lys Leu Phe 
    1550                 1555                 1560             


Ala Lys  Gly Asn Phe Cys Pro  Leu Cys Asp Lys Cys  Tyr Asp Asp 
    1565                 1570                 1575             


Asp Asp  Tyr Glu Ser Lys Met  Met Gln Cys Gly Lys  Cys Asp Arg 
    1580                 1585                 1590             


Trp Val  His Ser Lys Cys Glu  Asn Leu Ser Asp Glu  Met Tyr Glu 
    1595                 1600                 1605             


Ile Leu  Ser Asn Leu Pro Glu  Ser Val Ala Tyr Thr  Cys Val Asn 
    1610                 1615                 1620             


Cys Thr  Glu Arg His Pro Ala  Glu Trp Arg Leu Ala  Leu Glu Lys 
    1625                 1630                 1635             


Glu Leu  Gln Ile Ser Leu Lys  Gln Val Leu Thr Ala  Leu Leu Asn 
    1640                 1645                 1650             


Ser Arg  Thr Thr Ser His Leu  Leu Arg Tyr Arg Gln  Ala Ala Lys 
    1655                 1660                 1665             


Pro Pro  Asp Leu Asn Pro Glu  Thr Glu Glu Ser Ile  Pro Ser Arg 
    1670                 1675                 1680             


Ser Ser  Pro Glu Gly Pro Asp  Pro Pro Val Leu Thr  Glu Val Ser 
    1685                 1690                 1695             


Lys Gln  Asp Asp Gln Gln Pro  Leu Asp Leu Glu Gly  Val Lys Arg 
    1700                 1705                 1710             


Lys Met  Asp Gln Gly Asn Tyr  Thr Ser Val Leu Glu  Phe Ser Asp 
    1715                 1720                 1725             


Asp Ile  Val Lys Ile Ile Gln  Ala Ala Ile Asn Ser  Asp Gly Gly 
    1730                 1735                 1740             


Gln Pro  Glu Ile Lys Lys Ala  Asn Ser Met Val Lys  Ser Phe Phe 
    1745                 1750                 1755             


Ile Arg  Gln Met Glu Arg Val  Phe Pro Trp Phe Ser  Val Lys Lys 
    1760                 1765                 1770             


Ser Arg  Phe Trp Glu Pro Asn  Lys Val Ser Ser Asn  Ser Gly Met 
    1775                 1780                 1785             


Leu Pro  Asn Ala Val Leu Pro  Pro Ser Leu Asp His  Asn Tyr Ala 
    1790                 1795                 1800             


Gln Trp  Gln Glu Arg Glu Glu  Asn Ser His Thr Glu  Gln Pro Pro 
    1805                 1810                 1815             


Leu Met  Lys Lys Ile Ile Pro  Ala Pro Lys Pro Lys  Gly Pro Gly 
    1820                 1825                 1830             


Glu Pro  Asp Ser Pro Thr Pro  Leu His Pro Pro Thr  Pro Pro Ile 
    1835                 1840                 1845             


Leu Ser  Thr Asp Arg Ser Arg  Glu Asp Ser Pro Glu  Leu Asn Pro 
    1850                 1855                 1860             


Pro Pro  Gly Ile Glu Asp Asn  Arg Gln Cys Ala Leu  Cys Leu Thr 
    1865                 1870                 1875             


Tyr Gly  Asp Asp Ser Ala Asn  Asp Ala Gly Arg Leu  Leu Tyr Ile 
    1880                 1885                 1890             


Gly Gln  Asn Glu Trp Thr His  Val Asn Cys Ala Leu  Trp Ser Ala 
    1895                 1900                 1905             


Glu Val  Phe Glu Asp Asp Asp  Gly Ser Leu Lys Asn  Val His Met 
    1910                 1915                 1920             


Ala Val  Ile Arg Gly Lys Gln  Leu Arg Cys Glu Phe  Cys Gln Lys 
    1925                 1930                 1935             


Pro Gly  Ala Thr Val Gly Cys  Cys Leu Thr Ser Cys  Thr Ser Asn 
    1940                 1945                 1950             


Tyr His  Phe Met Cys Ser Arg  Ala Lys Asn Cys Val  Phe Leu Asp 
    1955                 1960                 1965             


Asp Lys  Lys Val Tyr Cys Gln  Arg His Arg Asp Leu  Ile Lys Gly 
    1970                 1975                 1980             


Glu Val  Val Pro Glu Asn Gly  Phe Glu Val Phe Arg  Arg Val Phe 
    1985                 1990                 1995             


Val Asp  Phe Glu Gly Ile Ser  Leu Arg Arg Lys Phe  Leu Asn Gly 
    2000                 2005                 2010             


Leu Glu  Pro Glu Asn Ile His  Met Met Ile Gly Ser  Met Thr Ile 
    2015                 2020                 2025             


Asp Cys  Leu Gly Ile Leu Asn  Asp Leu Ser Asp Cys  Glu Asp Lys 
    2030                 2035                 2040             


Leu Phe  Pro Ile Gly Tyr Gln  Cys Ser Arg Val Tyr  Trp Ser Thr 
    2045                 2050                 2055             


Thr Asp  Ala Arg Lys Arg Cys  Val Tyr Thr Cys Lys  Ile Val Glu 
    2060                 2065                 2070             


Cys Arg  Pro Pro Val Val Glu  Pro Asp Ile Asn Ser  Thr Val Glu 
    2075                 2080                 2085             


His Asp  Glu Asn Arg Thr Ile  Ala His Ser Pro Thr  Ser Phe Thr 
    2090                 2095                 2100             


Glu Ser  Ser Ser Lys Glu Ser  Gln Asn Thr Ala Glu  Ile Ile Ser 
    2105                 2110                 2115             


Pro Pro  Ser Pro Asp Arg Pro  Pro His Ser Gln Thr  Ser Gly Ser 
    2120                 2125                 2130             


Cys Tyr  Tyr His Val Ile Ser  Lys Val Pro Arg Ile  Arg Thr Pro 
    2135                 2140                 2145             


Ser Tyr  Ser Pro Thr Gln Arg  Ser Pro Gly Cys Arg  Pro Leu Pro 
    2150                 2155                 2160             


Ser Ala  Gly Ser Pro Thr Pro  Thr Thr His Glu Ile  Val Thr Val 
    2165                 2170                 2175             


Gly Asp  Pro Leu Leu Ser Ser  Gly Leu Arg Ser Ile  Gly Ser Arg 
    2180                 2185                 2190             


Arg His  Ser Thr Ser Ser Leu  Ser Pro Gln Arg Ser  Lys Leu Arg 
    2195                 2200                 2205             


Ile Met  Ser Pro Met Arg Thr  Gly Asn Thr Tyr Ser  Arg Asn Asn 
    2210                 2215                 2220             


Val Ser  Ser Val Ser Thr Thr  Gly Thr Ala Thr Asp  Leu Glu Ser 
    2225                 2230                 2235             


Ser Ala  Lys Val Val Asp His  Val Leu Gly Pro Leu  Asn Ser Ser 
    2240                 2245                 2250             


Thr Ser  Leu Gly Gln Asn Thr  Ser Thr Ser Ser Asn  Leu Gln Arg 
    2255                 2260                 2265             


Thr Val  Val Thr Val Gly Asn  Lys Asn Ser His Leu  Asp Gly Ser 
    2270                 2275                 2280             


Ser Ser  Ser Glu Met Lys Gln  Ser Ser Ala Ser Asp  Leu Val Ser 
    2285                 2290                 2295             


Lys Ser  Ser Ser Leu Lys Gly  Glu Lys Thr Lys Val  Leu Ser Ser 
    2300                 2305                 2310             


Lys Ser  Ser Glu Gly Ser Ala  His Asn Val Ala Tyr  Pro Gly Ile 
    2315                 2320                 2325             


Pro Lys  Leu Ala Pro Gln Val  His Asn Thr Thr Ser  Arg Glu Leu 
    2330                 2335                 2340             


Asn Val  Ser Lys Ile Gly Ser  Phe Ala Glu Pro Ser  Ser Val Ser 
    2345                 2350                 2355             


Phe Ser  Ser Lys Glu Ala Leu  Ser Phe Pro His Leu  His Leu Arg 
    2360                 2365                 2370             


Gly Gln  Arg Asn Asp Arg Asp  Gln His Thr Asp Ser  Thr Gln Ser 
    2375                 2380                 2385             


Ala Asn  Ser Ser Pro Asp Glu  Asp Thr Glu Val Lys  Thr Leu Lys 
    2390                 2395                 2400             


Leu Ser  Gly Met Ser Asn Arg  Ser Ser Ile Ile Asn  Glu His Met 
    2405                 2410                 2415             


Gly Ser  Ser Ser Arg Asp Arg  Arg Gln Lys Gly Lys  Lys Ser Cys 
    2420                 2425                 2430             


Lys Glu  Thr Phe Lys Glu Lys  His Ser Ser Lys Ser  Phe Leu Glu 
    2435                 2440                 2445             


Pro Gly  Gln Val Thr Thr Gly  Glu Glu Gly Asn Leu  Lys Pro Glu 
    2450                 2455                 2460             


Phe Met  Asp Glu Val Leu Thr  Pro Glu Tyr Met Gly  Gln Arg Pro 
    2465                 2470                 2475             


Cys Asn  Asn Val Ser Ser Asp  Lys Ile Gly Asp Lys  Gly Leu Ser 
    2480                 2485                 2490             


Met Pro  Gly Val Pro Lys Ala  Pro Pro Met Gln Val  Glu Gly Ser 
    2495                 2500                 2505             


Ala Lys  Glu Leu Gln Ala Pro  Arg Lys Arg Thr Val  Lys Val Thr 
    2510                 2515                 2520             


Leu Thr  Pro Leu Lys Met Glu  Asn Glu Ser Gln Ser  Lys Asn Ala 
    2525                 2530                 2535             


Leu Lys  Glu Ser Ser Pro Ala  Ser Pro Leu Gln Ile  Glu Ser Thr 
    2540                 2545                 2550             


Ser Pro  Thr Glu Pro Ile Ser  Ala Ser Glu Asn Pro  Gly Asp Gly 
    2555                 2560                 2565             


Pro Val  Ala Gln Pro Ser Pro  Asn Asn Thr Ser Cys  Gln Asp Ser 
    2570                 2575                 2580             


Gln Ser  Asn Asn Tyr Gln Asn  Leu Pro Val Gln Asp  Arg Asn Leu 
    2585                 2590                 2595             


Met Leu  Pro Asp Gly Pro Lys  Pro Gln Glu Asp Gly  Ser Phe Lys 
    2600                 2605                 2610             


Arg Arg  Tyr Pro Arg Arg Ser  Ala Arg Ala Arg Ser  Asn Met Phe 
    2615                 2620                 2625             


Phe Gly  Leu Thr Pro Leu Tyr  Gly Val Arg Ser Tyr  Gly Glu Glu 
    2630                 2635                 2640             


Asp Ile  Pro Phe Tyr Ser Ser  Ser Thr Gly Lys Lys  Arg Gly Lys 
    2645                 2650                 2655             


Arg Ser  Ala Glu Gly Gln Val  Asp Gly Ala Asp Asp  Leu Ser Thr 
    2660                 2665                 2670             


Ser Asp  Glu Asp Asp Leu Tyr  Tyr Tyr Asn Phe Thr  Arg Thr Val 
    2675                 2680                 2685             


Ile Ser  Ser Gly Gly Glu Glu  Arg Leu Ala Ser His  Asn Leu Phe 
    2690                 2695                 2700             


Arg Glu  Glu Glu Gln Cys Asp  Leu Pro Lys Ile Ser  Gln Leu Asp 
    2705                 2710                 2715             


Gly Val  Asp Asp Gly Thr Glu  Ser Asp Thr Ser Val  Thr Ala Thr 
    2720                 2725                 2730             


Thr Arg  Lys Ser Ser Gln Ile  Pro Lys Arg Asn Gly  Lys Glu Asn 
    2735                 2740                 2745             


Gly Thr  Glu Asn Leu Lys Ile  Asp Arg Pro Glu Asp  Ala Gly Glu 
    2750                 2755                 2760             


Lys Glu  His Val Thr Lys Ser  Ser Val Gly His Lys  Asn Glu Pro 
    2765                 2770                 2775             


Lys Met  Asp Asn Cys His Ser  Val Ser Arg Val Lys  Thr Gln Gly 
    2780                 2785                 2790             


Gln Asp  Ser Leu Glu Ala Gln  Leu Ser Ser Leu Glu  Ser Ser Arg 
    2795                 2800                 2805             


Arg Val  His Thr Ser Thr Pro  Ser Asp Lys Asn Leu  Leu Asp Thr 
    2810                 2815                 2820             


Tyr Asn  Thr Glu Leu Leu Lys  Ser Asp Ser Asp Asn  Asn Asn Ser 
    2825                 2830                 2835             


Asp Asp  Cys Gly Asn Ile Leu  Pro Ser Asp Ile Met  Asp Phe Val 
    2840                 2845                 2850             


Leu Lys  Asn Thr Pro Ser Met  Gln Ala Leu Gly Glu  Ser Pro Glu 
    2855                 2860                 2865             


Ser Ser  Ser Ser Glu Leu Leu  Asn Leu Gly Glu Gly  Leu Gly Leu 
    2870                 2875                 2880             


Asp Ser  Asn Arg Glu Lys Asp  Met Gly Leu Phe Glu  Val Phe Ser 
    2885                 2890                 2895             


Gln Gln  Leu Pro Thr Thr Glu  Pro Val Asp Ser Ser  Val Ser Ser 
    2900                 2905                 2910             


Ser Ile  Ser Ala Glu Glu Gln  Phe Glu Leu Pro Leu  Glu Leu Pro 
    2915                 2920                 2925             


Ser Asp  Leu Ser Val Leu Thr  Thr Arg Ser Pro Thr  Val Pro Ser 
    2930                 2935                 2940             


Gln Asn  Pro Ser Arg Leu Ala  Val Ile Ser Asp Ser  Gly Glu Lys 
    2945                 2950                 2955             


Arg Val  Thr Ile Thr Glu Lys  Ser Val Ala Ser Ser  Glu Ser Asp 
    2960                 2965                 2970             


Pro Ala  Leu Leu Ser Pro Gly  Val Asp Pro Thr Pro  Glu Gly His 
    2975                 2980                 2985             


Met Thr  Pro Asp His Phe Ile  Gln Gly His Met Asp  Ala Asp His 
    2990                 2995                 3000             


Ile Ser  Ser Pro Pro Cys Gly  Ser Val Glu Gln Gly  His Gly Asn 
    3005                 3010                 3015             


Asn Gln  Asp Leu Thr Arg Asn  Ser Ser Thr Pro Gly  Leu Gln Val 
    3020                 3025                 3030             


Pro Val  Ser Pro Thr Val Pro  Ile Gln Asn Gln Lys  Tyr Val Pro 
    3035                 3040                 3045             


Asn Ser  Thr Asp Ser Pro Gly  Pro Ser Gln Ile Ser  Asn Ala Ala 
    3050                 3055                 3060             


Val Gln  Thr Thr Pro Pro His  Leu Lys Pro Ala Thr  Glu Lys Leu 
    3065                 3070                 3075             


Ile Val  Val Asn Gln Asn Met  Gln Pro Leu Tyr Val  Leu Gln Thr 
    3080                 3085                 3090             


Leu Pro  Asn Gly Val Thr Gln  Lys Ile Gln Leu Thr  Ser Ser Val 
    3095                 3100                 3105             


Ser Ser  Thr Pro Ser Val Met  Glu Thr Asn Thr Ser  Val Leu Gly 
    3110                 3115                 3120             


Pro Met  Gly Gly Gly Leu Thr  Leu Thr Thr Gly Leu  Asn Pro Ser 
    3125                 3130                 3135             


Leu Pro  Thr Ser Gln Ser Leu  Phe Pro Ser Ala Ser  Lys Gly Leu 
    3140                 3145                 3150             


Leu Pro  Met Ser His His Gln  His Leu His Ser Phe  Pro Ala Ala 
    3155                 3160                 3165             


Thr Gln  Ser Ser Phe Pro Pro  Asn Ile Ser Asn Pro  Pro Ser Gly 
    3170                 3175                 3180             


Leu Leu  Ile Gly Val Gln Pro  Pro Pro Asp Pro Gln  Leu Leu Val 
    3185                 3190                 3195             


Ser Glu  Ser Ser Gln Arg Thr  Asp Leu Ser Thr Thr  Val Ala Thr 
    3200                 3205                 3210             


Pro Ser  Ser Gly Leu Lys Lys  Arg Pro Ile Ser Arg  Leu Gln Thr 
    3215                 3220                 3225             


Arg Lys  Asn Lys Lys Leu Ala  Pro Ser Ser Thr Pro  Ser Asn Ile 
    3230                 3235                 3240             


Ala Pro  Ser Asp Val Val Ser  Asn Met Thr Leu Ile  Asn Phe Thr 
    3245                 3250                 3255             


Pro Ser  Gln Leu Pro Asn His  Pro Ser Leu Leu Asp  Leu Gly Ser 
    3260                 3265                 3270             


Leu Asn  Thr Ser Ser His Arg  Thr Val Pro Asn Ile  Ile Lys Arg 
    3275                 3280                 3285             


Ser Lys  Ser Ser Ile Met Tyr  Phe Glu Pro Ala Pro  Leu Leu Pro 
    3290                 3295                 3300             


Gln Ser  Val Gly Gly Thr Ala  Ala Thr Ala Ala Gly  Thr Ser Thr 
    3305                 3310                 3315             


Ile Ser  Gln Asp Thr Ser His  Leu Thr Ser Gly Ser  Val Ser Gly 
    3320                 3325                 3330             


Leu Ala  Ser Ser Ser Ser Val  Leu Asn Val Val Ser  Met Gln Thr 
    3335                 3340                 3345             


Thr Thr  Thr Pro Thr Ser Ser  Ala Ser Val Pro Gly  His Val Thr 
    3350                 3355                 3360             


Leu Thr  Asn Pro Arg Leu Leu  Gly Thr Pro Asp Ile  Gly Ser Ile 
    3365                 3370                 3375             


Ser Asn  Leu Leu Ile Lys Ala  Ser Gln Gln Ser Leu  Gly Ile Gln 
    3380                 3385                 3390             


Asp Gln  Pro Val Ala Leu Pro  Pro Ser Ser Gly Met  Phe Pro Gln 
    3395                 3400                 3405             


Leu Gly  Thr Ser Gln Thr Pro  Ser Thr Ala Ala Ile  Thr Ala Ala 
    3410                 3415                 3420             


Ser Ser  Ile Cys Val Leu Pro  Ser Thr Gln Thr Thr  Gly Ile Thr 
    3425                 3430                 3435             


Ala Ala  Ser Pro Ser Gly Glu  Ala Asp Glu His Tyr  Gln Leu Gln 
    3440                 3445                 3450             


His Val  Asn Gln Leu Leu Ala  Ser Lys Thr Gly Ile  His Ser Ser 
    3455                 3460                 3465             


Gln Arg  Asp Leu Asp Ser Ala  Ser Gly Pro Gln Val  Ser Asn Phe 
    3470                 3475                 3480             


Thr Gln  Thr Val Asp Ala Pro  Asn Ser Met Gly Leu  Glu Gln Asn 
    3485                 3490                 3495             


Lys Ala  Leu Ser Ser Ala Val  Gln Ala Ser Pro Thr  Ser Pro Gly 
    3500                 3505                 3510             


Gly Ser  Pro Ser Ser Pro Ser  Ser Gly Gln Arg Ser  Ala Ser Pro 
    3515                 3520                 3525             


Ser Val  Pro Gly Pro Thr Lys  Pro Lys Pro Lys Thr  Lys Arg Phe 
    3530                 3535                 3540             


Gln Leu  Pro Leu Asp Lys Gly  Asn Gly Lys Lys His  Lys Val Ser 
    3545                 3550                 3555             


His Leu  Arg Thr Ser Ser Ser  Glu Ala His Ile Pro  Asp Gln Glu 
    3560                 3565                 3570             


Thr Thr  Ser Leu Thr Ser Gly  Thr Gly Thr Pro Gly  Ala Glu Ala 
    3575                 3580                 3585             


Glu Gln  Gln Asp Thr Ala Ser  Val Glu Gln Ser Ser  Gln Lys Glu 
    3590                 3595                 3600             


Cys Gly  Gln Pro Ala Gly Gln  Val Ala Val Leu Pro  Glu Val Gln 
    3605                 3610                 3615             


Val Thr  Gln Asn Pro Ala Asn  Glu Gln Glu Ser Ala  Glu Pro Lys 
    3620                 3625                 3630             


Thr Val  Glu Glu Glu Glu Ser  Asn Phe Ser Ser Pro  Leu Met Leu 
    3635                 3640                 3645             


Trp Leu  Gln Gln Glu Gln Lys  Arg Lys Glu Ser Ile  Thr Glu Lys 
    3650                 3655                 3660             


Lys Pro  Lys Lys Gly Leu Val  Phe Glu Ile Ser Ser  Asp Asp Gly 
    3665                 3670                 3675             


Phe Gln  Ile Cys Ala Glu Ser  Ile Glu Asp Ala Trp  Lys Ser Leu 
    3680                 3685                 3690             


Thr Asp  Lys Val Gln Glu Ala  Arg Ser Asn Ala Arg  Leu Lys Gln 
    3695                 3700                 3705             


Leu Ser  Phe Ala Gly Val Asn  Gly Leu Arg Met Leu  Gly Ile Leu 
    3710                 3715                 3720             


His Asp  Ala Val Val Phe Leu  Ile Glu Gln Leu Ser  Gly Ala Lys 
    3725                 3730                 3735             


His Cys  Arg Asn Tyr Lys Phe  Arg Phe His Lys Pro  Glu Glu Ala 
    3740                 3745                 3750             


Asn Glu  Pro Pro Leu Asn Pro  His Gly Ser Ala Arg  Ala Glu Val 
    3755                 3760                 3765             


His Leu  Arg Lys Ser Ala Phe  Asp Met Phe Asn Phe  Leu Ala Ser 
    3770                 3775                 3780             


Lys His  Arg Gln Pro Pro Glu  Tyr Asn Pro Asn Asp  Glu Glu Glu 
    3785                 3790                 3795             


Glu Glu  Val Gln Leu Lys Ser  Ala Arg Arg Ala Thr  Ser Met Asp 
    3800                 3805                 3810             


Leu Pro  Met Pro Met Arg Phe  Arg His Leu Lys Lys  Thr Ser Lys 
    3815                 3820                 3825             


Glu Ala  Val Gly Val Tyr Arg  Ser Pro Ile His Gly  Arg Gly Leu 
    3830                 3835                 3840             


Phe Cys  Lys Arg Asn Ile Asp  Ala Gly Glu Met Val  Ile Glu Tyr 
    3845                 3850                 3855             


Ala Gly  Asn Val Ile Arg Ser  Ile Gln Thr Asp Lys  Arg Glu Lys 
    3860                 3865                 3870             


Tyr Tyr  Asp Ser Lys Gly Ile  Gly Cys Tyr Met Phe  Arg Ile Asp 
    3875                 3880                 3885             


Asp Ser  Glu Val Val Asp Ala  Thr Met His Gly Asn  Ala Ala Arg 
    3890                 3895                 3900             


Phe Ile  Asn His Ser Cys Glu  Pro Asn Cys Tyr Ser  Arg Val Ile 
    3905                 3910                 3915             


Asn Ile  Asp Gly Gln Lys His  Ile Val Ile Phe Ala  Met Arg Lys 
    3920                 3925                 3930             


Ile Tyr  Arg Gly Glu Glu Leu  Thr Tyr Asp Tyr Lys  Phe Pro Ile 
    3935                 3940                 3945             


Glu Asp  Ala Ser Asn Lys Leu  Pro Cys Asn Cys Gly  Ala Lys Lys 
    3950                 3955                 3960             


Cys Arg  Lys Phe Leu Asn 
    3965                 


<210> 235
<211> 1912
<212> PRT
<213> Homo sapiens

<400> 235
Met Ala Ser Gly Leu Gly Ser Pro Ser Pro Cys Ser Ala Gly Ser Glu 
1               5                   10                  15      


Glu Glu Asp Met Asp Ala Leu Leu Asn Asn Ser Leu Pro Pro Pro His 
            20                  25                  30          


Pro Glu Asn Glu Glu Asp Pro Glu Glu Asp Leu Ser Glu Thr Glu Thr 
        35                  40                  45              


Pro Lys Leu Lys Lys Lys Lys Lys Pro Lys Lys Pro Arg Asp Pro Lys 
    50                  55                  60                  


Ile Pro Lys Ser Lys Arg Gln Lys Lys Glu Arg Met Leu Leu Cys Arg 
65                  70                  75                  80  


Gln Leu Gly Asp Ser Ser Gly Glu Gly Pro Glu Phe Val Glu Glu Glu 
                85                  90                  95      


Glu Glu Val Ala Leu Arg Ser Asp Ser Glu Gly Ser Asp Tyr Thr Pro 
            100                 105                 110         


Gly Lys Lys Lys Lys Lys Lys Leu Gly Pro Lys Lys Glu Lys Lys Ser 
        115                 120                 125             


Lys Ser Lys Arg Lys Glu Glu Glu Glu Glu Glu Asp Asp Asp Asp Asp 
    130                 135                 140                 


Ser Lys Glu Pro Lys Ser Ser Ala Gln Leu Leu Glu Asp Trp Gly Met 
145                 150                 155                 160 


Glu Asp Ile Asp His Val Phe Ser Glu Glu Asp Tyr Arg Thr Leu Thr 
                165                 170                 175     


Asn Tyr Lys Ala Phe Ser Gln Phe Val Arg Pro Leu Ile Ala Ala Lys 
            180                 185                 190         


Asn Pro Lys Ile Ala Val Ser Lys Met Met Met Val Leu Gly Ala Lys 
        195                 200                 205             


Trp Arg Glu Phe Ser Thr Asn Asn Pro Phe Lys Gly Ser Ser Gly Ala 
    210                 215                 220                 


Ser Val Ala Ala Ala Ala Ala Ala Ala Val Ala Val Val Glu Ser Met 
225                 230                 235                 240 


Val Thr Ala Thr Glu Val Ala Pro Pro Pro Pro Pro Val Glu Val Pro 
                245                 250                 255     


Ile Arg Lys Ala Lys Thr Lys Glu Gly Lys Gly Pro Asn Ala Arg Arg 
            260                 265                 270         


Lys Pro Lys Gly Ser Pro Arg Val Pro Asp Ala Lys Lys Pro Lys Pro 
        275                 280                 285             


Lys Lys Val Ala Pro Leu Lys Ile Lys Leu Gly Gly Phe Gly Ser Lys 
    290                 295                 300                 


Arg Lys Arg Ser Ser Ser Glu Asp Asp Asp Leu Asp Val Glu Ser Asp 
305                 310                 315                 320 


Phe Asp Asp Ala Ser Ile Asn Ser Tyr Ser Val Ser Asp Gly Ser Thr 
                325                 330                 335     


Ser Arg Ser Ser Arg Ser Arg Lys Lys Leu Arg Thr Thr Lys Lys Lys 
            340                 345                 350         


Lys Lys Gly Glu Glu Glu Val Thr Ala Val Asp Gly Tyr Glu Thr Asp 
        355                 360                 365             


His Gln Asp Tyr Cys Glu Val Cys Gln Gln Gly Gly Glu Ile Ile Leu 
    370                 375                 380                 


Cys Asp Thr Cys Pro Arg Ala Tyr His Met Val Cys Leu Asp Pro Asp 
385                 390                 395                 400 


Met Glu Lys Ala Pro Glu Gly Lys Trp Ser Cys Pro His Cys Glu Lys 
                405                 410                 415     


Glu Gly Ile Gln Trp Glu Ala Lys Glu Asp Asn Ser Glu Gly Glu Glu 
            420                 425                 430         


Ile Leu Glu Glu Val Gly Gly Asp Leu Glu Glu Glu Asp Asp His His 
        435                 440                 445             


Met Glu Phe Cys Arg Val Cys Lys Asp Gly Gly Glu Leu Leu Cys Cys 
    450                 455                 460                 


Asp Thr Cys Pro Ser Ser Tyr His Ile His Cys Leu Asn Pro Pro Leu 
465                 470                 475                 480 


Pro Glu Ile Pro Asn Gly Glu Trp Leu Cys Pro Arg Cys Thr Cys Pro 
                485                 490                 495     


Ala Leu Lys Gly Lys Val Gln Lys Ile Leu Ile Trp Lys Trp Gly Gln 
            500                 505                 510         


Pro Pro Ser Pro Thr Pro Val Pro Arg Pro Pro Asp Ala Asp Pro Asn 
        515                 520                 525             


Thr Pro Ser Pro Lys Pro Leu Glu Gly Arg Pro Glu Arg Gln Phe Phe 
    530                 535                 540                 


Val Lys Trp Gln Gly Met Ser Tyr Trp His Cys Ser Trp Val Ser Glu 
545                 550                 555                 560 


Leu Gln Leu Glu Leu His Cys Gln Val Met Phe Arg Asn Tyr Gln Arg 
                565                 570                 575     


Lys Asn Asp Met Asp Glu Pro Pro Ser Gly Asp Phe Gly Gly Asp Glu 
            580                 585                 590         


Glu Lys Ser Arg Lys Arg Lys Asn Lys Asp Pro Lys Phe Ala Glu Met 
        595                 600                 605             


Glu Glu Arg Phe Tyr Arg Tyr Gly Ile Lys Pro Glu Trp Met Met Ile 
    610                 615                 620                 


His Arg Ile Leu Asn His Ser Val Asp Lys Lys Gly His Val His Tyr 
625                 630                 635                 640 


Leu Ile Lys Trp Arg Asp Leu Pro Tyr Asp Gln Ala Ser Trp Glu Ser 
                645                 650                 655     


Glu Asp Val Glu Ile Gln Asp Tyr Asp Leu Phe Lys Gln Ser Tyr Trp 
            660                 665                 670         


Asn His Arg Glu Leu Met Arg Gly Glu Glu Gly Arg Pro Gly Lys Lys 
        675                 680                 685             


Leu Lys Lys Val Lys Leu Arg Lys Leu Glu Arg Pro Pro Glu Thr Pro 
    690                 695                 700                 


Thr Val Asp Pro Thr Val Lys Tyr Glu Arg Gln Pro Glu Tyr Leu Asp 
705                 710                 715                 720 


Ala Thr Gly Gly Thr Leu His Pro Tyr Gln Met Glu Gly Leu Asn Trp 
                725                 730                 735     


Leu Arg Phe Ser Trp Ala Gln Gly Thr Asp Thr Ile Leu Ala Asp Glu 
            740                 745                 750         


Met Gly Leu Gly Lys Thr Val Gln Thr Ala Val Phe Leu Tyr Ser Leu 
        755                 760                 765             


Tyr Lys Glu Gly His Ser Lys Gly Pro Phe Leu Val Ser Ala Pro Leu 
    770                 775                 780                 


Ser Thr Ile Ile Asn Trp Glu Arg Glu Phe Glu Met Trp Ala Pro Asp 
785                 790                 795                 800 


Met Tyr Val Val Thr Tyr Val Gly Asp Lys Asp Ser Arg Ala Ile Ile 
                805                 810                 815     


Arg Glu Asn Glu Phe Ser Phe Glu Asp Asn Ala Ile Arg Gly Gly Lys 
            820                 825                 830         


Lys Ala Ser Arg Met Lys Lys Glu Ala Ser Val Lys Phe His Val Leu 
        835                 840                 845             


Leu Thr Ser Tyr Glu Leu Ile Thr Ile Asp Met Ala Ile Leu Gly Ser 
    850                 855                 860                 


Ile Asp Trp Ala Cys Leu Ile Val Asp Glu Ala His Arg Leu Lys Asn 
865                 870                 875                 880 


Asn Gln Ser Lys Phe Phe Arg Val Leu Asn Gly Tyr Ser Leu Gln His 
                885                 890                 895     


Lys Leu Leu Leu Thr Gly Thr Pro Leu Gln Asn Asn Leu Glu Glu Leu 
            900                 905                 910         


Phe His Leu Leu Asn Phe Leu Thr Pro Glu Arg Phe His Asn Leu Glu 
        915                 920                 925             


Gly Phe Leu Glu Glu Phe Ala Asp Ile Ala Lys Glu Asp Gln Ile Lys 
    930                 935                 940                 


Lys Leu His Asp Met Leu Gly Pro His Met Leu Arg Arg Leu Lys Ala 
945                 950                 955                 960 


Asp Val Phe Lys Asn Met Pro Ser Lys Thr Glu Leu Ile Val Arg Val 
                965                 970                 975     


Glu Leu Ser Pro Met Gln Lys Lys Tyr Tyr Lys Tyr Ile Leu Thr Arg 
            980                 985                 990         


Asn Phe Glu Ala Leu Asn Ala Arg  Gly Gly Gly Asn Gln  Val Ser Leu 
        995                 1000                 1005             


Leu Asn  Val Val Met Asp Leu  Lys Lys Cys Cys Asn  His Pro Tyr 
    1010                 1015                 1020             


Leu Phe  Pro Val Ala Ala Met  Glu Ala Pro Lys Met  Pro Asn Gly 
    1025                 1030                 1035             


Met Tyr  Asp Gly Ser Ala Leu  Ile Arg Ala Ser Gly  Lys Leu Leu 
    1040                 1045                 1050             


Leu Leu  Gln Lys Met Leu Lys  Asn Leu Lys Glu Gly  Gly His Arg 
    1055                 1060                 1065             


Val Leu  Ile Phe Ser Gln Met  Thr Lys Met Leu Asp  Leu Leu Glu 
    1070                 1075                 1080             


Asp Phe  Leu Glu His Glu Gly  Tyr Lys Tyr Glu Arg  Ile Asp Gly 
    1085                 1090                 1095             


Gly Ile  Thr Gly Asn Met Arg  Gln Glu Ala Ile Asp  Arg Phe Asn 
    1100                 1105                 1110             


Ala Pro  Gly Ala Gln Gln Phe  Cys Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Ile Asn Leu  Ala Thr Ala Asp Thr  Val Ile Ile 
    1130                 1135                 1140             


Tyr Asp  Ser Asp Trp Asn Pro  His Asn Asp Ile Gln  Ala Phe Ser 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Asn Lys Lys Val Met  Ile Tyr Arg 
    1160                 1165                 1170             


Phe Val  Thr Arg Ala Ser Val  Glu Glu Arg Ile Thr  Gln Val Ala 
    1175                 1180                 1185             


Lys Lys  Lys Met Met Leu Thr  His Leu Val Val Arg  Pro Gly Leu 
    1190                 1195                 1200             


Gly Ser  Lys Thr Gly Ser Met  Ser Lys Gln Glu Leu  Asp Asp Ile 
    1205                 1210                 1215             


Leu Lys  Phe Gly Thr Glu Glu  Leu Phe Lys Asp Glu  Ala Thr Asp 
    1220                 1225                 1230             


Gly Gly  Gly Asp Asn Lys Glu  Gly Glu Asp Ser Ser  Val Ile His 
    1235                 1240                 1245             


Tyr Asp  Asp Lys Ala Ile Glu  Arg Leu Leu Asp Arg  Asn Gln Asp 
    1250                 1255                 1260             


Glu Thr  Glu Asp Thr Glu Leu  Gln Gly Met Asn Glu  Tyr Leu Ser 
    1265                 1270                 1275             


Ser Phe  Lys Val Ala Gln Tyr  Val Val Arg Glu Glu  Glu Met Gly 
    1280                 1285                 1290             


Glu Glu  Glu Glu Val Glu Arg  Glu Ile Ile Lys Gln  Glu Glu Ser 
    1295                 1300                 1305             


Val Asp  Pro Asp Tyr Trp Glu  Lys Leu Leu Arg His  His Tyr Glu 
    1310                 1315                 1320             


Gln Gln  Gln Glu Asp Leu Ala  Arg Asn Leu Gly Lys  Gly Lys Arg 
    1325                 1330                 1335             


Ile Arg  Lys Gln Val Asn Tyr  Asn Asp Gly Ser Gln  Glu Asp Arg 
    1340                 1345                 1350             


Asp Trp  Gln Asp Asp Gln Ser  Asp Asn Gln Ser Asp  Tyr Ser Val 
    1355                 1360                 1365             


Ala Ser  Glu Glu Gly Asp Glu  Asp Phe Asp Glu Arg  Ser Glu Ala 
    1370                 1375                 1380             


Pro Arg  Arg Pro Ser Arg Lys  Gly Leu Arg Asn Asp  Lys Asp Lys 
    1385                 1390                 1395             


Pro Leu  Pro Pro Leu Leu Ala  Arg Val Gly Gly Asn  Ile Glu Val 
    1400                 1405                 1410             


Leu Gly  Phe Asn Ala Arg Gln  Arg Lys Ala Phe Leu  Asn Ala Ile 
    1415                 1420                 1425             


Met Arg  Tyr Gly Met Pro Pro  Gln Asp Ala Phe Thr  Thr Gln Trp 
    1430                 1435                 1440             


Leu Val  Arg Asp Leu Arg Gly  Lys Ser Glu Lys Glu  Phe Lys Ala 
    1445                 1450                 1455             


Tyr Val  Ser Leu Phe Met Arg  His Leu Cys Glu Pro  Gly Ala Asp 
    1460                 1465                 1470             


Gly Ala  Glu Thr Phe Ala Asp  Gly Val Pro Arg Glu  Gly Leu Ser 
    1475                 1480                 1485             


Arg Gln  His Val Leu Thr Arg  Ile Gly Val Met Ser  Leu Ile Arg 
    1490                 1495                 1500             


Lys Lys  Val Gln Glu Phe Glu  His Val Asn Gly Arg  Trp Ser Met 
    1505                 1510                 1515             


Pro Glu  Leu Ala Glu Val Glu  Glu Asn Lys Lys Met  Ser Gln Pro 
    1520                 1525                 1530             


Gly Ser  Pro Ser Pro Lys Thr  Pro Thr Pro Ser Thr  Pro Gly Asp 
    1535                 1540                 1545             


Thr Gln  Pro Asn Thr Pro Ala  Pro Val Pro Pro Ala  Glu Asp Gly 
    1550                 1555                 1560             


Ile Lys  Ile Glu Glu Asn Ser  Leu Lys Glu Glu Glu  Ser Ile Glu 
    1565                 1570                 1575             


Gly Glu  Lys Glu Val Lys Ser  Thr Ala Pro Glu Thr  Ala Ile Glu 
    1580                 1585                 1590             


Cys Thr  Gln Ala Pro Ala Pro  Ala Ser Glu Asp Glu  Lys Val Val 
    1595                 1600                 1605             


Val Glu  Pro Pro Glu Gly Glu  Glu Lys Val Glu Lys  Ala Glu Val 
    1610                 1615                 1620             


Lys Glu  Arg Thr Glu Glu Pro  Met Glu Thr Glu Pro  Lys Gly Ala 
    1625                 1630                 1635             


Ala Asp  Val Glu Lys Val Glu  Glu Lys Ser Ala Ile  Asp Leu Thr 
    1640                 1645                 1650             


Pro Ile  Val Val Glu Asp Lys  Glu Glu Lys Lys Glu  Glu Glu Glu 
    1655                 1660                 1665             


Lys Lys  Glu Val Met Leu Gln  Asn Gly Glu Thr Pro  Lys Asp Leu 
    1670                 1675                 1680             


Asn Asp  Glu Lys Gln Lys Lys  Asn Ile Lys Gln Arg  Phe Met Phe 
    1685                 1690                 1695             


Asn Ile  Ala Asp Gly Gly Phe  Thr Glu Leu His Ser  Leu Trp Gln 
    1700                 1705                 1710             


Asn Glu  Glu Arg Ala Ala Thr  Val Thr Lys Lys Thr  Tyr Glu Ile 
    1715                 1720                 1725             


Trp His  Arg Arg His Asp Tyr  Trp Leu Leu Ala Gly  Ile Ile Asn 
    1730                 1735                 1740             


His Gly  Tyr Ala Arg Trp Gln  Asp Ile Gln Asn Asp  Pro Arg Tyr 
    1745                 1750                 1755             


Ala Ile  Leu Asn Glu Pro Phe  Lys Gly Glu Met Asn  Arg Gly Asn 
    1760                 1765                 1770             


Phe Leu  Glu Ile Lys Asn Lys  Phe Leu Ala Arg Arg  Phe Lys Leu 
    1775                 1780                 1785             


Leu Glu  Gln Ala Leu Val Ile  Glu Glu Gln Leu Arg  Arg Ala Ala 
    1790                 1795                 1800             


Tyr Leu  Asn Met Ser Glu Asp  Pro Ser His Pro Ser  Met Ala Leu 
    1805                 1810                 1815             


Asn Thr  Arg Phe Ala Glu Val  Glu Cys Leu Ala Glu  Ser His Gln 
    1820                 1825                 1830             


His Leu  Ser Lys Glu Ser Met  Ala Gly Asn Lys Pro  Ala Asn Ala 
    1835                 1840                 1845             


Val Leu  His Lys Val Leu Lys  Gln Leu Glu Glu Leu  Leu Ser Asp 
    1850                 1855                 1860             


Met Lys  Ala Asp Val Thr Arg  Leu Pro Ala Thr Ile  Ala Arg Ile 
    1865                 1870                 1875             


Pro Pro  Val Ala Val Arg Leu  Gln Met Ser Glu Arg  Asn Ile Leu 
    1880                 1885                 1890             


Ser Arg  Leu Ala Asn Arg Ala  Pro Glu Pro Thr Pro  Gln Gln Val 
    1895                 1900                 1905             


Ala Gln  Gln Gln 
    1910         


<210> 236
<211> 2696
<212> PRT
<213> Homo sapiens

<400> 236
Met Asp Gln Thr Cys Glu Leu Pro Arg Arg Asn Cys Leu Leu Pro Phe 
1               5                   10                  15      


Ser Asn Pro Val Asn Leu Asp Ala Pro Glu Asp Lys Asp Ser Pro Phe 
            20                  25                  30          


Gly Asn Gly Gln Ser Asn Phe Ser Glu Pro Leu Asn Gly Cys Thr Met 
        35                  40                  45              


Gln Leu Ser Thr Val Ser Gly Thr Ser Gln Asn Ala Tyr Gly Gln Asp 
    50                  55                  60                  


Ser Pro Ser Cys Tyr Ile Pro Leu Arg Arg Leu Gln Asp Leu Ala Ser 
65                  70                  75                  80  


Met Ile Asn Val Glu Tyr Leu Asn Gly Ser Ala Asp Gly Ser Glu Ser 
                85                  90                  95      


Phe Gln Asp Pro Glu Lys Ser Asp Ser Arg Ala Gln Thr Pro Ile Val 
            100                 105                 110         


Cys Thr Ser Leu Ser Pro Gly Gly Pro Thr Ala Leu Ala Met Lys Gln 
        115                 120                 125             


Glu Pro Ser Cys Asn Asn Ser Pro Glu Leu Gln Val Lys Val Thr Lys 
    130                 135                 140                 


Thr Ile Lys Asn Gly Phe Leu His Phe Glu Asn Phe Thr Cys Val Asp 
145                 150                 155                 160 


Asp Ala Asp Val Asp Ser Glu Met Asp Pro Glu Gln Pro Val Thr Glu 
                165                 170                 175     


Asp Glu Ser Ile Glu Glu Ile Phe Glu Glu Thr Gln Thr Asn Ala Thr 
            180                 185                 190         


Cys Asn Tyr Glu Thr Lys Ser Glu Asn Gly Val Lys Val Ala Met Gly 
        195                 200                 205             


Ser Glu Gln Asp Ser Thr Pro Glu Ser Arg His Gly Ala Val Lys Ser 
    210                 215                 220                 


Pro Phe Leu Pro Leu Ala Pro Gln Thr Glu Thr Gln Lys Asn Lys Gln 
225                 230                 235                 240 


Arg Asn Glu Val Asp Gly Ser Asn Glu Lys Ala Ala Leu Leu Pro Ala 
                245                 250                 255     


Pro Phe Ser Leu Gly Asp Thr Asn Ile Thr Ile Glu Glu Gln Leu Asn 
            260                 265                 270         


Ser Ile Asn Leu Ser Phe Gln Asp Asp Pro Asp Ser Ser Thr Ser Thr 
        275                 280                 285             


Leu Gly Asn Met Leu Glu Leu Pro Gly Thr Ser Ser Ser Ser Thr Ser 
    290                 295                 300                 


Gln Glu Leu Pro Phe Cys Gln Pro Lys Lys Lys Ser Thr Pro Leu Lys 
305                 310                 315                 320 


Tyr Glu Val Gly Asp Leu Ile Trp Ala Lys Phe Lys Arg Arg Pro Trp 
                325                 330                 335     


Trp Pro Cys Arg Ile Cys Ser Asp Pro Leu Ile Asn Thr His Ser Lys 
            340                 345                 350         


Met Lys Val Ser Asn Arg Arg Pro Tyr Arg Gln Tyr Tyr Val Glu Ala 
        355                 360                 365             


Phe Gly Asp Pro Ser Glu Arg Ala Trp Val Ala Gly Lys Ala Ile Val 
    370                 375                 380                 


Met Phe Glu Gly Arg His Gln Phe Glu Glu Leu Pro Val Leu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gln Lys Glu Lys Gly Tyr Arg His Lys Val Pro Gln Lys 
                405                 410                 415     


Ile Leu Ser Lys Trp Glu Ala Ser Val Gly Leu Ala Glu Gln Tyr Asp 
            420                 425                 430         


Val Pro Lys Gly Ser Lys Asn Arg Lys Cys Ile Pro Gly Ser Ile Lys 
        435                 440                 445             


Leu Asp Ser Glu Glu Asp Met Pro Phe Glu Asp Cys Thr Asn Asp Pro 
    450                 455                 460                 


Glu Ser Glu His Asp Leu Leu Leu Asn Gly Cys Leu Lys Ser Leu Ala 
465                 470                 475                 480 


Phe Asp Ser Glu His Ser Ala Asp Glu Lys Glu Lys Pro Cys Ala Lys 
                485                 490                 495     


Ser Arg Ala Arg Lys Ser Ser Asp Asn Pro Lys Arg Thr Ser Val Lys 
            500                 505                 510         


Lys Gly His Ile Gln Phe Glu Ala His Lys Asp Glu Arg Arg Gly Lys 
        515                 520                 525             


Ile Pro Glu Asn Leu Gly Leu Asn Phe Ile Ser Gly Asp Ile Ser Asp 
    530                 535                 540                 


Thr Gln Ala Ser Asn Glu Leu Ser Arg Ile Ala Asn Ser Leu Thr Gly 
545                 550                 555                 560 


Ser Asn Thr Ala Pro Gly Ser Phe Leu Phe Ser Ser Cys Gly Lys Asn 
                565                 570                 575     


Thr Ala Lys Lys Glu Phe Glu Thr Ser Asn Gly Asp Ser Leu Leu Gly 
            580                 585                 590         


Leu Pro Glu Gly Ala Leu Ile Ser Lys Cys Ser Arg Glu Lys Asn Lys 
        595                 600                 605             


Pro Gln Arg Ser Leu Val Cys Gly Ser Lys Val Lys Leu Cys Tyr Ile 
    610                 615                 620                 


Gly Ala Gly Asp Glu Glu Lys Arg Ser Asp Ser Ile Ser Ile Cys Thr 
625                 630                 635                 640 


Thr Ser Asp Asp Gly Ser Ser Asp Leu Asp Pro Ile Glu His Ser Ser 
                645                 650                 655     


Glu Ser Asp Asn Ser Val Leu Glu Ile Pro Asp Ala Phe Asp Arg Thr 
            660                 665                 670         


Glu Asn Met Leu Ser Met Gln Lys Asn Glu Lys Ile Lys Tyr Ser Arg 
        675                 680                 685             


Phe Ala Ala Thr Asn Thr Arg Val Lys Ala Lys Gln Lys Pro Leu Ile 
    690                 695                 700                 


Ser Asn Ser His Thr Asp His Leu Met Gly Cys Thr Lys Ser Ala Glu 
705                 710                 715                 720 


Pro Gly Thr Glu Thr Ser Gln Val Asn Leu Ser Asp Leu Lys Ala Ser 
                725                 730                 735     


Thr Leu Val His Lys Pro Gln Ser Asp Phe Thr Asn Asp Ala Leu Ser 
            740                 745                 750         


Pro Lys Phe Asn Leu Ser Ser Ser Ile Ser Ser Glu Asn Ser Leu Ile 
        755                 760                 765             


Lys Gly Gly Ala Ala Asn Gln Ala Leu Leu His Ser Lys Ser Lys Gln 
    770                 775                 780                 


Pro Lys Phe Arg Ser Ile Lys Cys Lys His Lys Glu Asn Pro Val Met 
785                 790                 795                 800 


Ala Glu Pro Pro Val Ile Asn Glu Glu Cys Ser Leu Lys Cys Cys Ser 
                805                 810                 815     


Ser Asp Thr Lys Gly Ser Pro Leu Ala Ser Ile Ser Lys Ser Gly Lys 
            820                 825                 830         


Val Asp Gly Leu Lys Leu Leu Asn Asn Met His Glu Lys Thr Arg Asp 
        835                 840                 845             


Ser Ser Asp Ile Glu Thr Ala Val Val Lys His Val Leu Ser Glu Leu 
    850                 855                 860                 


Lys Glu Leu Ser Tyr Arg Ser Leu Gly Glu Asp Val Ser Asp Ser Gly 
865                 870                 875                 880 


Thr Ser Lys Pro Ser Lys Pro Leu Leu Phe Ser Ser Ala Ser Ser Gln 
                885                 890                 895     


Asn His Ile Pro Ile Glu Pro Asp Tyr Lys Phe Ser Thr Leu Leu Met 
            900                 905                 910         


Met Leu Lys Asp Met His Asp Ser Lys Thr Lys Glu Gln Arg Leu Met 
        915                 920                 925             


Thr Ala Gln Asn Leu Val Ser Tyr Arg Ser Pro Gly Arg Gly Asp Cys 
    930                 935                 940                 


Ser Thr Asn Ser Pro Val Gly Val Ser Lys Val Leu Val Ser Gly Gly 
945                 950                 955                 960 


Ser Thr His Asn Ser Glu Lys Lys Gly Asp Gly Thr Gln Asn Ser Ala 
                965                 970                 975     


Asn Pro Ser Pro Ser Gly Gly Asp Ser Ala Leu Ser Gly Glu Leu Ser 
            980                 985                 990         


Ala Ser Leu Pro Gly Leu Leu Ser  Asp Lys Arg Asp Leu  Pro Ala Ser 
        995                 1000                 1005             


Gly Lys  Ser Arg Ser Asp Cys  Val Thr Arg Arg Asn  Cys Gly Arg 
    1010                 1015                 1020             


Ser Lys  Pro Ser Ser Lys Leu  Arg Asp Ala Phe Ser  Ala Gln Met 
    1025                 1030                 1035             


Val Lys  Asn Thr Val Asn Arg  Lys Ala Leu Lys Thr  Glu Arg Lys 
    1040                 1045                 1050             


Arg Lys  Leu Asn Gln Leu Pro  Ser Val Thr Leu Asp  Ala Val Leu 
    1055                 1060                 1065             


Gln Gly  Asp Arg Glu Arg Gly  Gly Ser Leu Arg Gly  Gly Ala Glu 
    1070                 1075                 1080             


Asp Pro  Ser Lys Glu Asp Pro  Leu Gln Ile Met Gly  His Leu Thr 
    1085                 1090                 1095             


Ser Glu  Asp Gly Asp His Phe  Ser Asp Val His Phe  Asp Ser Lys 
    1100                 1105                 1110             


Val Lys  Gln Ser Asp Pro Gly  Lys Ile Ser Glu Lys  Gly Leu Ser 
    1115                 1120                 1125             


Phe Glu  Asn Gly Lys Gly Pro  Glu Leu Asp Ser Val  Met Asn Ser 
    1130                 1135                 1140             


Glu Asn  Asp Glu Leu Asn Gly  Val Asn Gln Val Val  Pro Lys Lys 
    1145                 1150                 1155             


Arg Trp  Gln Arg Leu Asn Gln  Arg Arg Thr Lys Pro  Arg Lys Arg 
    1160                 1165                 1170             


Met Asn  Arg Phe Lys Glu Lys  Glu Asn Ser Glu Cys  Ala Phe Arg 
    1175                 1180                 1185             


Val Leu  Leu Pro Ser Asp Pro  Val Gln Glu Gly Arg  Asp Glu Phe 
    1190                 1195                 1200             


Pro Glu  His Arg Thr Pro Ser  Ala Ser Ile Leu Glu  Glu Pro Leu 
    1205                 1210                 1215             


Thr Glu  Gln Asn His Ala Asp  Cys Leu Asp Ser Ala  Gly Pro Arg 
    1220                 1225                 1230             


Leu Asn  Val Cys Asp Lys Ser  Ser Ala Ser Ile Gly  Asp Met Glu 
    1235                 1240                 1245             


Lys Glu  Pro Gly Ile Pro Ser  Leu Thr Pro Gln Ala  Glu Leu Pro 
    1250                 1255                 1260             


Glu Pro  Ala Val Arg Ser Glu  Lys Lys Arg Leu Arg  Lys Pro Ser 
    1265                 1270                 1275             


Lys Trp  Leu Leu Glu Tyr Thr  Glu Glu Tyr Asp Gln  Ile Phe Ala 
    1280                 1285                 1290             


Pro Lys  Lys Lys Gln Lys Lys  Val Gln Glu Gln Val  His Lys Val 
    1295                 1300                 1305             


Ser Ser  Arg Cys Glu Glu Glu  Ser Leu Leu Ala Arg  Gly Arg Ser 
    1310                 1315                 1320             


Ser Ala  Gln Asn Lys Gln Val  Asp Glu Asn Ser Leu  Ile Ser Thr 
    1325                 1330                 1335             


Lys Glu  Glu Pro Pro Val Leu  Glu Arg Glu Ala Pro  Phe Leu Glu 
    1340                 1345                 1350             


Gly Pro  Leu Ala Gln Ser Glu  Leu Gly Gly Gly His  Ala Glu Leu 
    1355                 1360                 1365             


Pro Gln  Leu Thr Leu Ser Val  Pro Val Ala Pro Glu  Val Ser Pro 
    1370                 1375                 1380             


Arg Pro  Ala Leu Glu Ser Glu  Glu Leu Leu Val Lys  Thr Pro Gly 
    1385                 1390                 1395             


Asn Tyr  Glu Ser Lys Arg Gln  Arg Lys Pro Thr Lys  Lys Leu Leu 
    1400                 1405                 1410             


Glu Ser  Asn Asp Leu Asp Pro  Gly Phe Met Pro Lys  Lys Gly Asp 
    1415                 1420                 1425             


Leu Gly  Leu Ser Lys Lys Cys  Tyr Glu Ala Gly His  Leu Glu Asn 
    1430                 1435                 1440             


Gly Ile  Thr Glu Ser Cys Ala  Thr Ser Tyr Ser Lys  Asp Phe Gly 
    1445                 1450                 1455             


Gly Gly  Thr Thr Lys Ile Phe  Asp Lys Pro Arg Lys  Arg Lys Arg 
    1460                 1465                 1470             


Gln Arg  His Ala Ala Ala Lys  Met Gln Cys Lys Lys  Val Lys Asn 
    1475                 1480                 1485             


Asp Asp  Ser Ser Lys Glu Ile  Pro Gly Ser Glu Gly  Glu Leu Met 
    1490                 1495                 1500             


Pro His  Arg Thr Ala Thr Ser  Pro Lys Glu Thr Val  Glu Glu Gly 
    1505                 1510                 1515             


Val Glu  His Asp Pro Gly Met  Pro Ala Ser Lys Lys  Met Gln Gly 
    1520                 1525                 1530             


Glu Arg  Gly Gly Gly Ala Ala  Leu Lys Glu Asn Val  Cys Gln Asn 
    1535                 1540                 1545             


Cys Glu  Lys Leu Gly Glu Leu  Leu Leu Cys Glu Ala  Gln Cys Cys 
    1550                 1555                 1560             


Gly Ala  Phe His Leu Glu Cys  Leu Gly Leu Thr Glu  Met Pro Arg 
    1565                 1570                 1575             


Gly Lys  Phe Ile Cys Asn Glu  Cys Arg Thr Gly Ile  His Thr Cys 
    1580                 1585                 1590             


Phe Val  Cys Lys Gln Ser Gly  Glu Asp Val Lys Arg  Cys Leu Leu 
    1595                 1600                 1605             


Pro Leu  Cys Gly Lys Phe Tyr  His Glu Glu Cys Val  Gln Lys Tyr 
    1610                 1615                 1620             


Pro Pro  Thr Val Met Gln Asn  Lys Gly Phe Arg Cys  Ser Leu His 
    1625                 1630                 1635             


Ile Cys  Ile Thr Cys His Ala  Ala Asn Pro Ala Asn  Val Ser Ala 
    1640                 1645                 1650             


Ser Lys  Gly Arg Leu Met Arg  Cys Val Arg Cys Pro  Val Ala Tyr 
    1655                 1660                 1665             


His Ala  Asn Asp Phe Cys Leu  Ala Ala Gly Ser Lys  Ile Leu Ala 
    1670                 1675                 1680             


Ser Asn  Ser Ile Ile Cys Pro  Asn His Phe Thr Pro  Arg Arg Gly 
    1685                 1690                 1695             


Cys Arg  Asn His Glu His Val  Asn Val Ser Trp Cys  Phe Val Cys 
    1700                 1705                 1710             


Ser Glu  Gly Gly Ser Leu Leu  Cys Cys Asp Ser Cys  Pro Ala Ala 
    1715                 1720                 1725             


Phe His  Arg Glu Cys Leu Asn  Ile Asp Ile Pro Glu  Gly Asn Trp 
    1730                 1735                 1740             


Tyr Cys  Asn Asp Cys Lys Ala  Gly Lys Lys Pro His  Tyr Arg Glu 
    1745                 1750                 1755             


Ile Val  Trp Val Lys Val Gly  Arg Tyr Arg Trp Trp  Pro Ala Glu 
    1760                 1765                 1770             


Ile Cys  His Pro Arg Ala Val  Pro Ser Asn Ile Asp  Lys Met Arg 
    1775                 1780                 1785             


His Asp  Val Gly Glu Phe Pro  Val Leu Phe Phe Gly  Ser Asn Asp 
    1790                 1795                 1800             


Tyr Leu  Trp Thr His Gln Ala  Arg Val Phe Pro Tyr  Met Glu Gly 
    1805                 1810                 1815             


Asp Val  Ser Ser Lys Asp Lys  Met Gly Lys Gly Val  Asp Gly Thr 
    1820                 1825                 1830             


Tyr Lys  Lys Ala Leu Gln Glu  Ala Ala Ala Arg Phe  Glu Glu Leu 
    1835                 1840                 1845             


Lys Ala  Gln Lys Glu Leu Arg  Gln Leu Gln Glu Asp  Arg Lys Asn 
    1850                 1855                 1860             


Asp Lys  Lys Pro Pro Pro Tyr  Lys His Ile Lys Val  Asn Arg Pro 
    1865                 1870                 1875             


Ile Gly  Arg Val Gln Ile Phe  Thr Ala Asp Leu Ser  Glu Ile Pro 
    1880                 1885                 1890             


Arg Cys  Asn Cys Lys Ala Thr  Asp Glu Asn Pro Cys  Gly Ile Asp 
    1895                 1900                 1905             


Ser Glu  Cys Ile Asn Arg Met  Leu Leu Tyr Glu Cys  His Pro Thr 
    1910                 1915                 1920             


Val Cys  Pro Ala Gly Gly Arg  Cys Gln Asn Gln Cys  Phe Ser Lys 
    1925                 1930                 1935             


Arg Gln  Tyr Pro Glu Val Glu  Ile Phe Arg Thr Leu  Gln Arg Gly 
    1940                 1945                 1950             


Trp Gly  Leu Arg Thr Lys Thr  Asp Ile Lys Lys Gly  Glu Phe Val 
    1955                 1960                 1965             


Asn Glu  Tyr Val Gly Glu Leu  Ile Asp Glu Glu Glu  Cys Arg Ala 
    1970                 1975                 1980             


Arg Ile  Arg Tyr Ala Gln Glu  His Asp Ile Thr Asn  Phe Tyr Met 
    1985                 1990                 1995             


Leu Thr  Leu Asp Lys Asp Arg  Ile Ile Asp Ala Gly  Pro Lys Gly 
    2000                 2005                 2010             


Asn Tyr  Ala Arg Phe Met Asn  His Cys Cys Gln Pro  Asn Cys Glu 
    2015                 2020                 2025             


Thr Gln  Lys Trp Ser Val Asn  Gly Asp Thr Arg Val  Gly Leu Phe 
    2030                 2035                 2040             


Ala Leu  Ser Asp Ile Lys Ala  Gly Thr Glu Leu Thr  Phe Asn Tyr 
    2045                 2050                 2055             


Asn Leu  Glu Cys Leu Gly Asn  Gly Lys Thr Val Cys  Lys Cys Gly 
    2060                 2065                 2070             


Ala Pro  Asn Cys Ser Gly Phe  Leu Gly Val Arg Pro  Lys Asn Gln 
    2075                 2080                 2085             


Pro Ile  Ala Thr Glu Glu Lys  Ser Lys Lys Phe Lys  Lys Lys Gln 
    2090                 2095                 2100             


Gln Gly  Lys Arg Arg Thr Gln  Gly Glu Ile Thr Lys  Glu Arg Glu 
    2105                 2110                 2115             


Asp Glu  Cys Phe Ser Cys Gly  Asp Ala Gly Gln Leu  Val Ser Cys 
    2120                 2125                 2130             


Lys Lys  Pro Gly Cys Pro Lys  Val Tyr His Ala Asp  Cys Leu Asn 
    2135                 2140                 2145             


Leu Thr  Lys Arg Pro Ala Gly  Lys Trp Glu Cys Pro  Trp His Gln 
    2150                 2155                 2160             


Cys Asp  Ile Cys Gly Lys Glu  Ala Ala Ser Phe Cys  Glu Met Cys 
    2165                 2170                 2175             


Pro Ser  Ser Phe Cys Lys Gln  His Arg Glu Gly Met  Leu Phe Ile 
    2180                 2185                 2190             


Ser Lys  Leu Asp Gly Arg Leu  Ser Cys Thr Glu His  Asp Pro Cys 
    2195                 2200                 2205             


Gly Pro  Asn Pro Leu Glu Pro  Gly Glu Ile Arg Glu  Tyr Val Pro 
    2210                 2215                 2220             


Pro Pro  Val Pro Leu Pro Pro  Gly Pro Ser Thr His  Leu Ala Glu 
    2225                 2230                 2235             


Gln Ser  Thr Gly Met Ala Ala  Gln Ala Pro Lys Met  Ser Asp Lys 
    2240                 2245                 2250             


Pro Pro  Ala Asp Thr Asn Gln  Met Leu Ser Leu Ser  Lys Lys Ala 
    2255                 2260                 2265             


Leu Ala  Gly Thr Cys Gln Arg  Pro Leu Leu Pro Glu  Arg Pro Leu 
    2270                 2275                 2280             


Glu Arg  Thr Asp Ser Arg Pro  Gln Pro Leu Asp Lys  Val Arg Asp 
    2285                 2290                 2295             


Leu Ala  Gly Ser Gly Thr Lys  Ser Gln Ser Leu Val  Ser Ser Gln 
    2300                 2305                 2310             


Arg Pro  Leu Asp Arg Pro Pro  Ala Val Ala Gly Pro  Arg Pro Gln 
    2315                 2320                 2325             


Leu Ser  Asp Lys Pro Ser Pro  Val Thr Ser Pro Ser  Ser Ser Pro 
    2330                 2335                 2340             


Ser Val  Arg Ser Gln Pro Leu  Glu Arg Pro Leu Gly  Thr Ala Asp 
    2345                 2350                 2355             


Pro Arg  Leu Asp Lys Ser Ile  Gly Ala Ala Ser Pro  Arg Pro Gln 
    2360                 2365                 2370             


Ser Leu  Glu Lys Thr Ser Val  Pro Thr Gly Leu Arg  Leu Pro Pro 
    2375                 2380                 2385             


Pro Asp  Arg Leu Leu Ile Thr  Ser Ser Pro Lys Pro  Gln Thr Ser 
    2390                 2395                 2400             


Asp Arg  Pro Thr Asp Lys Pro  His Ala Ser Leu Ser  Gln Arg Leu 
    2405                 2410                 2415             


Pro Pro  Pro Glu Lys Val Leu  Ser Ala Val Val Gln  Thr Leu Val 
    2420                 2425                 2430             


Ala Lys  Glu Lys Ala Leu Arg  Pro Val Asp Gln Asn  Thr Gln Ser 
    2435                 2440                 2445             


Lys Asn  Arg Ala Ala Leu Val  Met Asp Leu Ile Asp  Leu Thr Pro 
    2450                 2455                 2460             


Arg Gln  Lys Glu Arg Ala Ala  Ser Pro His Gln Val  Thr Pro Gln 
    2465                 2470                 2475             


Ala Asp  Glu Lys Met Pro Val  Leu Glu Ser Ser Ser  Trp Pro Ala 
    2480                 2485                 2490             


Ser Lys  Gly Leu Gly His Met  Pro Arg Ala Val Glu  Lys Gly Cys 
    2495                 2500                 2505             


Val Ser  Asp Pro Leu Gln Thr  Ser Gly Lys Ala Ala  Ala Pro Ser 
    2510                 2515                 2520             


Glu Asp  Pro Trp Gln Ala Val  Lys Ser Leu Thr Gln  Ala Arg Leu 
    2525                 2530                 2535             


Leu Ser  Gln Pro Pro Ala Lys  Ala Phe Leu Tyr Glu  Pro Thr Thr 
    2540                 2545                 2550             


Gln Ala  Ser Gly Arg Ala Ser  Ala Gly Ala Glu Gln  Thr Pro Gly 
    2555                 2560                 2565             


Pro Leu  Ser Gln Ser Pro Gly  Leu Val Lys Gln Ala  Lys Gln Met 
    2570                 2575                 2580             


Val Gly  Gly Gln Gln Leu Pro  Ala Leu Ala Ala Lys  Ser Gly Gln 
    2585                 2590                 2595             


Ser Phe  Arg Ser Leu Gly Lys  Ala Pro Ala Ser Leu  Pro Thr Glu 
    2600                 2605                 2610             


Glu Lys  Lys Leu Val Thr Thr  Glu Gln Ser Pro Trp  Ala Leu Gly 
    2615                 2620                 2625             


Lys Ala  Ser Ser Arg Ala Gly  Leu Trp Pro Ile Val  Ala Gly Gln 
    2630                 2635                 2640             


Thr Leu  Ala Gln Ser Cys Trp  Ser Ala Gly Ser Thr  Gln Thr Leu 
    2645                 2650                 2655             


Ala Gln  Thr Cys Trp Ser Leu  Gly Arg Gly Gln Asp  Pro Lys Pro 
    2660                 2665                 2670             


Glu Gln  Asn Thr Leu Pro Ala  Leu Asn Gln Ala Pro  Ser Ser His 
    2675                 2680                 2685             


Lys Cys  Ala Glu Ser Glu Gln  Lys 
    2690                 2695     


<210> 237
<211> 2210
<212> PRT
<213> Homo sapiens

<400> 237
Met Thr Ala Ala Ala Asn Trp Val Ala Asn Gly Ala Ser Leu Glu Asp 
1               5                   10                  15      


Cys His Ser Asn Leu Phe Ser Leu Ala Glu Leu Thr Gly Ile Lys Trp 
            20                  25                  30          


Arg Arg Tyr Asn Phe Gly Gly His Gly Asp Cys Gly Pro Ile Ile Ser 
        35                  40                  45              


Ala Pro Ala Gln Asp Asp Pro Ile Leu Leu Ser Phe Ile Arg Cys Leu 
    50                  55                  60                  


Gln Ala Asn Leu Leu Cys Val Trp Arg Arg Asp Val Lys Pro Asp Cys 
65                  70                  75                  80  


Lys Glu Leu Trp Ile Phe Trp Trp Gly Asp Glu Pro Asn Leu Val Gly 
                85                  90                  95      


Val Ile His His Glu Leu Gln Val Val Glu Glu Gly Leu Trp Glu Asn 
            100                 105                 110         


Gly Leu Ser Tyr Glu Cys Arg Thr Leu Leu Phe Lys Ala Ile His Asn 
        115                 120                 125             


Leu Leu Glu Arg Cys Leu Met Asp Lys Asn Phe Val Arg Ile Gly Lys 
    130                 135                 140                 


Trp Phe Val Arg Pro Tyr Glu Lys Asp Glu Lys Pro Val Asn Lys Ser 
145                 150                 155                 160 


Glu His Leu Ser Cys Ala Phe Thr Phe Phe Leu His Gly Glu Ser Asn 
                165                 170                 175     


Val Cys Thr Ser Val Glu Ile Ala Gln His Gln Pro Ile Tyr Leu Ile 
            180                 185                 190         


Asn Glu Glu His Ile His Met Ala Gln Ser Ser Pro Ala Pro Phe Gln 
        195                 200                 205             


Val Leu Val Ser Pro Tyr Gly Leu Asn Gly Thr Leu Thr Gly Gln Ala 
    210                 215                 220                 


Tyr Lys Met Ser Asp Pro Ala Thr Arg Lys Leu Ile Glu Glu Trp Gln 
225                 230                 235                 240 


Tyr Phe Tyr Pro Met Val Leu Lys Lys Lys Glu Glu Ser Lys Glu Glu 
                245                 250                 255     


Asp Glu Leu Gly Tyr Asp Asp Asp Phe Pro Val Ala Val Glu Val Ile 
            260                 265                 270         


Val Gly Gly Val Arg Met Val Tyr Pro Ser Ala Phe Val Leu Ile Ser 
        275                 280                 285             


Gln Asn Asp Ile Pro Val Pro Gln Ser Val Ala Ser Ala Gly Gly His 
    290                 295                 300                 


Ile Ala Val Gly Gln Gln Gly Leu Gly Ser Val Lys Asp Pro Ser Asn 
305                 310                 315                 320 


Cys Gly Met Pro Leu Thr Pro Pro Thr Ser Pro Glu Gln Ala Ile Leu 
                325                 330                 335     


Gly Glu Ser Gly Gly Met Gln Ser Ala Ala Ser His Leu Val Ser Gln 
            340                 345                 350         


Asp Gly Gly Met Ile Thr Met His Ser Pro Lys Arg Ser Gly Lys Ile 
        355                 360                 365             


Pro Pro Lys Leu His Asn His Met Val His Arg Val Trp Lys Glu Cys 
    370                 375                 380                 


Ile Leu Asn Arg Thr Gln Ser Lys Arg Ser Gln Met Ser Thr Pro Thr 
385                 390                 395                 400 


Leu Glu Glu Glu Pro Ala Ser Asn Pro Ala Thr Trp Asp Phe Val Asp 
                405                 410                 415     


Pro Thr Gln Arg Val Ser Cys Ser Cys Ser Arg His Lys Leu Leu Lys 
            420                 425                 430         


Arg Cys Ala Val Gly Pro Asn Arg Pro Pro Thr Val Ser Gln Pro Gly 
        435                 440                 445             


Phe Ser Ala Gly Pro Ser Ser Ser Ser Ser Leu Pro Pro Pro Ala Ser 
    450                 455                 460                 


Ser Lys His Lys Thr Ala Glu Arg Gln Glu Lys Gly Asp Lys Leu Gln 
465                 470                 475                 480 


Lys Arg Pro Leu Ile Pro Phe His His Arg Pro Ser Val Ala Glu Glu 
                485                 490                 495     


Leu Cys Met Glu Gln Asp Thr Pro Gly Gln Lys Leu Gly Leu Ala Gly 
            500                 505                 510         


Ile Asp Ser Ser Leu Glu Val Ser Ser Ser Arg Lys Tyr Asp Lys Gln 
        515                 520                 525             


Met Ala Val Pro Ser Arg Asn Thr Ser Lys Gln Met Asn Leu Asn Pro 
    530                 535                 540                 


Met Asp Ser Pro His Ser Pro Ile Ser Pro Leu Pro Pro Thr Leu Ser 
545                 550                 555                 560 


Pro Gln Pro Arg Gly Gln Glu Thr Glu Ser Leu Asp Pro Pro Ser Val 
                565                 570                 575     


Pro Val Asn Pro Ala Leu Tyr Gly Asn Gly Leu Glu Leu Gln Gln Leu 
            580                 585                 590         


Ser Thr Leu Asp Asp Arg Thr Val Leu Val Gly Gln Arg Leu Pro Leu 
        595                 600                 605             


Met Ala Glu Val Ser Glu Thr Ala Leu Tyr Cys Gly Ile Arg Pro Ser 
    610                 615                 620                 


Asn Pro Glu Ser Ser Glu Lys Trp Trp His Ser Tyr Arg Leu Pro Pro 
625                 630                 635                 640 


Ser Asp Asp Ala Glu Phe Arg Pro Pro Glu Leu Gln Gly Glu Arg Cys 
                645                 650                 655     


Asp Ala Lys Met Glu Val Asn Ser Glu Ser Thr Ala Leu Gln Arg Leu 
            660                 665                 670         


Leu Ala Gln Pro Asn Lys Arg Phe Lys Ile Trp Gln Asp Lys Gln Pro 
        675                 680                 685             


Gln Leu Gln Pro Leu His Phe Leu Asp Pro Leu Pro Leu Ser Gln Gln 
    690                 695                 700                 


Pro Gly Asp Ser Leu Gly Glu Val Asn Asp Pro Tyr Thr Phe Glu Asp 
705                 710                 715                 720 


Gly Asp Ile Lys Tyr Ile Phe Thr Ala Asn Lys Lys Cys Lys Gln Gly 
                725                 730                 735     


Thr Glu Lys Asp Ser Leu Lys Lys Asn Lys Ser Glu Asp Gly Phe Gly 
            740                 745                 750         


Thr Lys Asp Val Thr Thr Pro Gly His Ser Thr Pro Val Pro Asp Gly 
        755                 760                 765             


Lys Asn Ala Met Ser Ile Phe Ser Ser Ala Thr Lys Thr Asp Val Arg 
    770                 775                 780                 


Gln Asp Asn Ala Ala Gly Arg Ala Gly Ser Ser Ser Leu Thr Gln Val 
785                 790                 795                 800 


Thr Asp Leu Ala Pro Ser Leu His Asp Leu Asp Asn Ile Phe Asp Asn 
                805                 810                 815     


Ser Asp Asp Asp Glu Leu Gly Ala Val Ser Pro Ala Leu Arg Ser Ser 
            820                 825                 830         


Lys Met Pro Ala Val Gly Thr Glu Asp Arg Pro Leu Gly Lys Asp Gly 
        835                 840                 845             


Arg Ala Ala Val Pro Tyr Pro Pro Thr Val Ala Asp Leu Gln Arg Met 
    850                 855                 860                 


Phe Pro Thr Pro Pro Ser Leu Glu Gln His Pro Ala Phe Ser Pro Val 
865                 870                 875                 880 


Met Asn Tyr Lys Asp Gly Ile Ser Ser Glu Thr Val Thr Ala Leu Gly 
                885                 890                 895     


Met Met Glu Ser Pro Met Val Ser Met Val Ser Thr Gln Leu Thr Glu 
            900                 905                 910         


Phe Lys Met Glu Val Glu Asp Gly Leu Gly Ser Pro Lys Pro Glu Glu 
        915                 920                 925             


Ile Lys Asp Phe Ser Tyr Val His Lys Val Pro Ser Phe Gln Pro Phe 
    930                 935                 940                 


Val Gly Ser Ser Met Phe Ala Pro Leu Lys Met Leu Pro Ser His Cys 
945                 950                 955                 960 


Leu Leu Pro Leu Lys Ile Pro Asp Ala Cys Leu Phe Arg Pro Ser Trp 
                965                 970                 975     


Ala Ile Pro Pro Lys Ile Glu Gln Leu Pro Met Pro Pro Ala Ala Thr 
            980                 985                 990         


Phe Ile Arg Asp Gly Tyr Asn Asn  Val Pro Ser Val Gly  Ser Leu Ala 
        995                 1000                 1005             


Asp Pro  Asp Tyr Leu Asn Thr  Pro Gln Met Asn Thr  Pro Val Thr 
    1010                 1015                 1020             


Leu Asn  Ser Ala Ala Pro Ala  Ser Asn Ser Gly Ala  Gly Val Leu 
    1025                 1030                 1035             


Pro Ser  Pro Ala Thr Pro Arg  Phe Ser Val Pro Thr  Pro Arg Thr 
    1040                 1045                 1050             


Pro Arg  Thr Pro Arg Thr Pro  Arg Gly Gly Gly Thr  Ala Ser Gly 
    1055                 1060                 1065             


Gln Gly  Ser Val Lys Tyr Asp  Ser Thr Asp Gln Gly  Ser Pro Ala 
    1070                 1075                 1080             


Ser Thr  Pro Ser Thr Thr Arg  Pro Leu Asn Ser Val  Glu Pro Ala 
    1085                 1090                 1095             


Thr Met  Gln Pro Ile Pro Glu  Ala His Ser Leu Tyr  Val Thr Leu 
    1100                 1105                 1110             


Ile Leu  Ser Asp Ser Val Met  Asn Ile Phe Lys Asp  Arg Asn Phe 
    1115                 1120                 1125             


Asp Ser  Cys Cys Ile Cys Ala  Cys Asn Met Asn Ile  Lys Gly Ala 
    1130                 1135                 1140             


Asp Val  Gly Leu Tyr Ile Pro  Asp Ser Ser Asn Glu  Asp Gln Tyr 
    1145                 1150                 1155             


Arg Cys  Thr Cys Gly Phe Ser  Ala Ile Met Asn Arg  Lys Leu Gly 
    1160                 1165                 1170             


Tyr Asn  Ser Gly Leu Phe Leu  Glu Asp Glu Leu Asp  Ile Phe Gly 
    1175                 1180                 1185             


Lys Asn  Ser Asp Ile Gly Gln  Ala Ala Glu Arg Arg  Leu Met Met 
    1190                 1195                 1200             


Cys Gln  Ser Thr Phe Leu Pro  Gln Val Glu Gly Thr  Lys Lys Pro 
    1205                 1210                 1215             


Gln Glu  Pro Pro Ile Ser Leu  Leu Leu Leu Leu Gln  Asn Gln His 
    1220                 1225                 1230             


Thr Gln  Pro Phe Ala Ser Leu  Asn Phe Leu Asp Tyr  Ile Ser Ser 
    1235                 1240                 1245             


Asn Asn  Arg Gln Thr Leu Pro  Cys Val Ser Trp Ser  Tyr Asp Arg 
    1250                 1255                 1260             


Val Gln  Ala Asp Asn Asn Asp  Tyr Trp Thr Glu Cys  Phe Asn Ala 
    1265                 1270                 1275             


Leu Glu  Gln Gly Arg Gln Tyr  Val Asp Asn Pro Thr  Gly Gly Lys 
    1280                 1285                 1290             


Val Asp  Glu Ala Leu Val Arg  Ser Ala Thr Val His  Ser Trp Pro 
    1295                 1300                 1305             


His Ser  Asn Val Leu Asp Ile  Ser Met Leu Ser Ser  Gln Asp Val 
    1310                 1315                 1320             


Val Arg  Met Leu Leu Ser Leu  Gln Pro Phe Leu Gln  Asp Ala Ile 
    1325                 1330                 1335             


Gln Lys  Lys Arg Thr Gly Arg  Thr Trp Glu Asn Ile  Gln His Val 
    1340                 1345                 1350             


Gln Gly  Pro Leu Thr Trp Gln  Gln Phe His Lys Met  Ala Gly Arg 
    1355                 1360                 1365             


Gly Thr  Tyr Gly Ser Glu Glu  Ser Pro Glu Pro Leu  Pro Ile Pro 
    1370                 1375                 1380             


Thr Leu  Leu Val Gly Tyr Asp  Lys Asp Phe Leu Thr  Ile Ser Pro 
    1385                 1390                 1395             


Phe Ser  Leu Pro Phe Trp Glu  Arg Leu Leu Leu Asp  Pro Tyr Gly 
    1400                 1405                 1410             


Gly His  Arg Asp Val Ala Tyr  Ile Val Val Cys Pro  Glu Asn Glu 
    1415                 1420                 1425             


Ala Leu  Leu Glu Gly Ala Lys  Thr Phe Phe Arg Asp  Leu Ser Ala 
    1430                 1435                 1440             


Val Tyr  Glu Met Cys Arg Leu  Gly Gln His Lys Pro  Ile Cys Lys 
    1445                 1450                 1455             


Val Leu  Arg Asp Gly Ile Met  Arg Val Gly Lys Thr  Val Ala Gln 
    1460                 1465                 1470             


Lys Leu  Thr Asp Glu Leu Val  Ser Glu Trp Phe Asn  Gln Pro Trp 
    1475                 1480                 1485             


Ser Gly  Glu Glu Asn Asp Asn  His Ser Arg Leu Lys  Leu Tyr Ala 
    1490                 1495                 1500             


Gln Val  Cys Arg His His Leu  Ala Pro Tyr Leu Ala  Thr Leu Gln 
    1505                 1510                 1515             


Leu Asp  Ser Ser Leu Leu Ile  Pro Pro Lys Tyr Gln  Thr Pro Pro 
    1520                 1525                 1530             


Ala Ala  Ala Gln Gly Gln Ala  Thr Pro Gly Asn Ala  Gly Pro Leu 
    1535                 1540                 1545             


Ala Pro  Asn Gly Ser Ala Ala  Pro Pro Ala Gly Ser  Ala Phe Asn 
    1550                 1555                 1560             


Pro Thr  Ser Asn Ser Ser Ser  Thr Asn Pro Ala Ala  Ser Ser Ser 
    1565                 1570                 1575             


Ala Ser  Gly Ser Ser Val Pro  Pro Val Ser Ser Ser  Ala Ser Ala 
    1580                 1585                 1590             


Pro Gly  Ile Ser Gln Ile Ser  Thr Thr Ser Ser Ser  Gly Phe Ser 
    1595                 1600                 1605             


Gly Ser  Val Gly Gly Gln Asn  Pro Ser Thr Gly Gly  Ile Ser Ala 
    1610                 1615                 1620             


Asp Arg  Thr Gln Gly Asn Ile  Gly Cys Gly Gly Asp  Thr Asp Pro 
    1625                 1630                 1635             


Gly Gln  Ser Ser Ser Gln Pro  Ser Gln Asp Gly Gln  Glu Ser Val 
    1640                 1645                 1650             


Thr Glu  Arg Glu Arg Ile Gly  Ile Pro Thr Glu Pro  Asp Ser Ala 
    1655                 1660                 1665             


Asp Ser  His Ala His Pro Pro  Ala Val Val Ile Tyr  Met Val Asp 
    1670                 1675                 1680             


Pro Phe  Thr Tyr Ala Ala Glu  Glu Asp Ser Thr Ser  Gly Asn Phe 
    1685                 1690                 1695             


Trp Leu  Leu Ser Leu Met Arg  Cys Tyr Thr Glu Met  Leu Asp Asn 
    1700                 1705                 1710             


Leu Pro  Glu His Met Arg Asn  Ser Phe Ile Leu Gln  Ile Val Pro 
    1715                 1720                 1725             


Cys Gln  Tyr Met Leu Gln Thr  Met Lys Asp Glu Gln  Val Phe Tyr 
    1730                 1735                 1740             


Ile Gln  Tyr Leu Lys Ser Met  Ala Phe Ser Val Tyr  Cys Gln Cys 
    1745                 1750                 1755             


Arg Arg  Pro Leu Pro Thr Gln  Ile His Ile Lys Ser  Leu Thr Gly 
    1760                 1765                 1770             


Phe Gly  Pro Ala Ala Ser Ile  Glu Met Thr Leu Lys  Asn Pro Glu 
    1775                 1780                 1785             


Arg Pro  Ser Pro Ile Gln Leu  Tyr Ser Pro Pro Phe  Ile Leu Ala 
    1790                 1795                 1800             


Pro Ile  Lys Asp Lys Gln Thr  Glu Leu Gly Glu Thr  Phe Gly Glu 
    1805                 1810                 1815             


Ala Ser  Gln Lys Tyr Asn Val  Leu Phe Val Gly Tyr  Cys Leu Ser 
    1820                 1825                 1830             


His Asp  Gln Arg Trp Leu Leu  Ala Ser Cys Thr Asp  Leu His Gly 
    1835                 1840                 1845             


Glu Leu  Leu Glu Thr Cys Val  Val Asn Ile Ala Leu  Pro Asn Arg 
    1850                 1855                 1860             


Ser Arg  Arg Ser Lys Val Ser  Ala Arg Lys Ile Gly  Leu Gln Lys 
    1865                 1870                 1875             


Leu Trp  Glu Trp Cys Ile Gly  Ile Val Gln Met Thr  Ser Leu Pro 
    1880                 1885                 1890             


Trp Arg  Val Val Ile Gly Arg  Leu Gly Arg Leu Gly  His Gly Glu 
    1895                 1900                 1905             


Leu Lys  Asp Trp Ser Ile Leu  Leu Gly Glu Cys Ser  Leu Gln Thr 
    1910                 1915                 1920             


Ile Ser  Lys Lys Leu Lys Asp  Val Cys Arg Met Cys  Gly Ile Ser 
    1925                 1930                 1935             


Ala Ala  Asp Ser Pro Ser Ile  Leu Ser Ala Cys Leu  Val Ala Met 
    1940                 1945                 1950             


Glu Pro  Gln Gly Ser Phe Val  Val Met Pro Asp Ala  Val Thr Met 
    1955                 1960                 1965             


Gly Ser  Val Phe Gly Arg Ser  Thr Ala Leu Asn Met  Gln Ser Ser 
    1970                 1975                 1980             


Gln Leu  Asn Thr Pro Gln Asp  Ala Ser Cys Thr His  Ile Leu Val 
    1985                 1990                 1995             


Phe Pro  Thr Ser Ser Thr Ile  Gln Val Ala Pro Ala  Asn Tyr Pro 
    2000                 2005                 2010             


Asn Glu  Asp Gly Phe Ser Pro  Asn Asn Asp Asp Met  Phe Val Asp 
    2015                 2020                 2025             


Leu Pro  Phe Pro Asp Asp Met  Asp Asn Asp Ile Gly  Ile Leu Met 
    2030                 2035                 2040             


Thr Gly  Asn Leu His Ser Ser  Pro Asn Ser Ser Pro  Val Pro Ser 
    2045                 2050                 2055             


Pro Gly  Ser Pro Ser Gly Ile  Gly Val Gly Ser His  Phe Gln His 
    2060                 2065                 2070             


Ser Arg  Ser Gln Gly Glu Arg  Leu Leu Ser Arg Glu  Ala Pro Glu 
    2075                 2080                 2085             


Glu Leu  Lys Gln Gln Pro Leu  Ala Leu Gly Tyr Phe  Val Ser Thr 
    2090                 2095                 2100             


Ala Lys  Ala Glu Asn Leu Pro  Gln Trp Phe Trp Ser  Ser Cys Pro 
    2105                 2110                 2115             


Gln Ala  Gln Asn Gln Cys Pro  Leu Phe Leu Lys Ala  Ser Leu His 
    2120                 2125                 2130             


His His  Ile Ser Val Ala Gln  Thr Asp Glu Leu Leu  Pro Ala Arg 
    2135                 2140                 2145             


Asn Ser  Gln Arg Val Pro His  Pro Leu Asp Ser Lys  Thr Thr Ser 
    2150                 2155                 2160             


Asp Val  Leu Arg Phe Val Leu  Glu Gln Tyr Asn Ala  Leu Ser Trp 
    2165                 2170                 2175             


Leu Thr  Cys Asn Pro Ala Thr  Gln Asp Arg Thr Ser  Cys Leu Pro 
    2180                 2185                 2190             


Val His  Phe Val Val Leu Thr  Gln Leu Tyr Asn Ala  Ile Met Asn 
    2195                 2200                 2205             


Ile Leu  
    2210 


<210> 238
<211> 1233
<212> PRT
<213> Homo sapiens

<400> 238
Met Gly Phe Leu Lys Leu Ile Glu Ile Glu Asn Phe Lys Ser Tyr Lys 
1               5                   10                  15      


Gly Arg Gln Ile Ile Gly Pro Phe Gln Arg Phe Thr Ala Ile Ile Gly 
            20                  25                  30          


Pro Asn Gly Ser Gly Lys Ser Asn Leu Met Asp Ala Ile Ser Phe Val 
        35                  40                  45              


Leu Gly Glu Lys Thr Ser Asn Leu Arg Val Lys Thr Leu Arg Asp Leu 
    50                  55                  60                  


Ile His Gly Ala Pro Val Gly Lys Pro Ala Ala Asn Arg Ala Phe Val 
65                  70                  75                  80  


Ser Met Val Tyr Ser Glu Glu Gly Ala Glu Asp Arg Thr Phe Ala Arg 
                85                  90                  95      


Val Ile Val Gly Gly Ser Ser Glu Tyr Lys Ile Asn Asn Lys Val Val 
            100                 105                 110         


Gln Leu His Glu Tyr Ser Glu Glu Leu Glu Lys Leu Gly Ile Leu Ile 
        115                 120                 125             


Lys Ala Arg Asn Phe Leu Val Phe Gln Gly Ala Val Glu Ser Ile Ala 
    130                 135                 140                 


Met Lys Asn Pro Lys Glu Arg Thr Ala Leu Phe Glu Glu Ile Ser Arg 
145                 150                 155                 160 


Ser Gly Glu Leu Ala Gln Glu Tyr Asp Lys Arg Lys Lys Glu Met Val 
                165                 170                 175     


Lys Ala Glu Glu Asp Thr Gln Phe Asn Tyr His Arg Lys Lys Asn Ile 
            180                 185                 190         


Ala Ala Glu Arg Lys Glu Ala Lys Gln Glu Lys Glu Glu Ala Asp Arg 
        195                 200                 205             


Tyr Gln Arg Leu Lys Asp Glu Val Val Arg Ala Gln Val Gln Leu Gln 
    210                 215                 220                 


Leu Phe Lys Leu Tyr His Asn Glu Val Glu Ile Glu Lys Leu Asn Lys 
225                 230                 235                 240 


Glu Leu Ala Ser Lys Asn Lys Glu Ile Glu Lys Asp Lys Lys Arg Met 
                245                 250                 255     


Asp Lys Val Glu Asp Glu Leu Lys Glu Lys Lys Lys Glu Leu Gly Lys 
            260                 265                 270         


Met Met Arg Glu Gln Gln Gln Ile Glu Lys Glu Ile Lys Glu Lys Asp 
        275                 280                 285             


Ser Glu Leu Asn Gln Lys Arg Pro Gln Tyr Ile Lys Ala Lys Glu Asn 
    290                 295                 300                 


Thr Ser His Lys Ile Lys Lys Leu Glu Ala Ala Lys Lys Ser Leu Gln 
305                 310                 315                 320 


Asn Ala Gln Lys His Tyr Lys Lys Arg Lys Gly Asp Met Asp Glu Leu 
                325                 330                 335     


Glu Lys Glu Met Leu Ser Val Glu Lys Ala Arg Gln Glu Phe Glu Glu 
            340                 345                 350         


Arg Met Glu Glu Glu Ser Gln Ser Gln Gly Arg Asp Leu Thr Leu Glu 
        355                 360                 365             


Glu Asn Gln Val Lys Lys Tyr His Arg Leu Lys Glu Glu Ala Ser Lys 
    370                 375                 380                 


Arg Ala Ala Thr Leu Ala Gln Glu Leu Glu Lys Phe Asn Arg Asp Gln 
385                 390                 395                 400 


Lys Ala Asp Gln Asp Arg Leu Asp Leu Glu Glu Arg Lys Lys Val Glu 
                405                 410                 415     


Thr Glu Ala Lys Ile Lys Gln Lys Leu Arg Glu Ile Glu Glu Asn Gln 
            420                 425                 430         


Lys Arg Ile Glu Lys Leu Glu Glu Tyr Ile Thr Thr Ser Lys Gln Ser 
        435                 440                 445             


Leu Glu Glu Gln Lys Lys Leu Glu Gly Glu Leu Thr Glu Glu Val Glu 
    450                 455                 460                 


Met Ala Lys Arg Arg Ile Asp Glu Ile Asn Lys Glu Leu Asn Gln Val 
465                 470                 475                 480 


Met Glu Gln Leu Gly Asp Ala Arg Ile Asp Arg Gln Glu Ser Ser Arg 
                485                 490                 495     


Gln Gln Arg Lys Ala Glu Ile Met Glu Ser Ile Lys Arg Leu Tyr Pro 
            500                 505                 510         


Gly Ser Val Tyr Gly Arg Leu Ile Asp Leu Cys Gln Pro Thr Gln Lys 
        515                 520                 525             


Lys Tyr Gln Ile Ala Val Thr Lys Val Leu Gly Lys Asn Met Asp Ala 
    530                 535                 540                 


Ile Ile Val Asp Ser Glu Lys Thr Gly Arg Asp Cys Ile Gln Tyr Ile 
545                 550                 555                 560 


Lys Glu Gln Arg Gly Glu Pro Glu Thr Phe Leu Pro Leu Asp Tyr Leu 
                565                 570                 575     


Glu Val Lys Pro Thr Asp Glu Lys Leu Arg Glu Leu Lys Gly Ala Lys 
            580                 585                 590         


Leu Val Ile Asp Val Ile Arg Tyr Glu Pro Pro His Ile Lys Lys Ala 
        595                 600                 605             


Leu Gln Tyr Ala Cys Gly Asn Ala Leu Val Cys Asp Asn Val Glu Asp 
    610                 615                 620                 


Ala Arg Arg Ile Ala Phe Gly Gly His Gln Arg His Lys Thr Val Ala 
625                 630                 635                 640 


Leu Asp Gly Thr Leu Phe Gln Lys Ser Gly Val Ile Ser Gly Gly Ala 
                645                 650                 655     


Ser Asp Leu Lys Ala Lys Ala Arg Arg Trp Asp Glu Lys Ala Val Asp 
            660                 665                 670         


Lys Leu Lys Glu Lys Lys Glu Arg Leu Thr Glu Glu Leu Lys Glu Gln 
        675                 680                 685             


Met Lys Ala Lys Arg Lys Glu Ala Glu Leu Arg Gln Val Gln Ser Gln 
    690                 695                 700                 


Ala His Gly Leu Gln Met Arg Leu Lys Tyr Ser Gln Ser Asp Leu Glu 
705                 710                 715                 720 


Gln Thr Lys Thr Arg His Leu Ala Leu Asn Leu Gln Glu Lys Ser Lys 
                725                 730                 735     


Leu Glu Ser Glu Leu Ala Asn Phe Gly Pro Arg Ile Asn Asp Ile Lys 
            740                 745                 750         


Arg Ile Ile Gln Ser Arg Glu Arg Glu Met Lys Asp Leu Lys Glu Lys 
        755                 760                 765             


Met Asn Gln Val Glu Asp Glu Val Phe Glu Glu Phe Cys Arg Glu Ile 
    770                 775                 780                 


Gly Val Arg Asn Ile Arg Glu Phe Glu Glu Glu Lys Val Lys Arg Gln 
785                 790                 795                 800 


Asn Glu Ile Ala Lys Lys Arg Leu Glu Phe Glu Asn Gln Lys Thr Arg 
                805                 810                 815     


Leu Gly Ile Gln Leu Asp Phe Glu Lys Asn Gln Leu Lys Glu Asp Gln 
            820                 825                 830         


Asp Lys Val His Met Trp Glu Gln Thr Val Lys Lys Asp Glu Asn Glu 
        835                 840                 845             


Ile Glu Lys Leu Lys Lys Glu Glu Gln Arg His Met Lys Ile Ile Asp 
    850                 855                 860                 


Glu Thr Met Ala Gln Leu Gln Asp Leu Lys Asn Gln His Leu Ala Lys 
865                 870                 875                 880 


Lys Ser Glu Val Asn Asp Lys Asn His Glu Met Glu Glu Ile Arg Lys 
                885                 890                 895     


Lys Leu Gly Gly Ala Asn Lys Glu Met Thr His Leu Gln Lys Glu Val 
            900                 905                 910         


Thr Ala Ile Glu Thr Lys Leu Glu Gln Lys Arg Ser Asp Arg His Asn 
        915                 920                 925             


Leu Leu Gln Ala Cys Lys Met Gln Asp Ile Lys Leu Pro Leu Ser Lys 
    930                 935                 940                 


Gly Thr Met Asp Asp Ile Ser Gln Glu Glu Gly Ser Ser Gln Gly Glu 
945                 950                 955                 960 


Asp Ser Val Ser Gly Ser Gln Arg Ile Ser Ser Ile Tyr Ala Arg Glu 
                965                 970                 975     


Ala Leu Ile Glu Ile Asp Tyr Gly Asp Leu Cys Glu Asp Leu Lys Asp 
            980                 985                 990         


Ala Gln Ala Glu Glu Glu Ile Lys  Gln Glu Met Asn Thr  Leu Gln Gln 
        995                 1000                 1005             


Lys Leu  Asn Glu Gln Gln Ser  Val Leu Gln Arg Ile  Ala Ala Pro 
    1010                 1015                 1020             


Asn Met  Lys Ala Met Glu Lys  Leu Glu Ser Val Arg  Asp Lys Phe 
    1025                 1030                 1035             


Gln Glu  Thr Ser Asp Glu Phe  Glu Ala Ala Arg Lys  Arg Ala Lys 
    1040                 1045                 1050             


Lys Ala  Lys Gln Ala Phe Glu  Gln Ile Lys Lys Glu  Arg Phe Asp 
    1055                 1060                 1065             


Arg Phe  Asn Ala Cys Phe Glu  Ser Val Ala Thr Asn  Ile Asp Glu 
    1070                 1075                 1080             


Ile Tyr  Lys Ala Leu Ser Arg  Asn Ser Ser Ala Gln  Ala Phe Leu 
    1085                 1090                 1095             


Gly Pro  Glu Asn Pro Glu Glu  Pro Tyr Leu Asp Gly  Ile Asn Tyr 
    1100                 1105                 1110             


Asn Cys  Val Ala Pro Gly Lys  Arg Phe Arg Pro Met  Asp Asn Leu 
    1115                 1120                 1125             


Ser Gly  Gly Glu Lys Thr Val  Ala Ala Leu Ala Leu  Leu Phe Ala 
    1130                 1135                 1140             


Ile His  Ser Tyr Lys Pro Ala  Pro Phe Phe Val Leu  Asp Glu Ile 
    1145                 1150                 1155             


Asp Ala  Ala Leu Asp Asn Thr  Asn Ile Gly Lys Val  Ala Asn Tyr 
    1160                 1165                 1170             


Ile Lys  Glu Gln Ser Thr Cys  Asn Phe Gln Ala Ile  Val Ile Ser 
    1175                 1180                 1185             


Leu Lys  Glu Glu Phe Tyr Thr  Lys Ala Glu Ser Leu  Ile Gly Val 
    1190                 1195                 1200             


Tyr Pro  Glu Gln Gly Asp Cys  Val Ile Ser Lys Val  Leu Thr Phe 
    1205                 1210                 1215             


Asp Leu  Thr Lys Tyr Pro Asp  Ala Asn Pro Asn Pro  Asn Glu Gln 
    1220                 1225                 1230             


<210> 239
<211> 1590
<212> PRT
<213> Homo sapiens

<400> 239
Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln 
225                 230                 235                 240 


Gln Gln Pro Pro Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu 
                245                 250                 255     


Val Asn Tyr Asn Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro 
            260                 265                 270         


Ser Thr Pro Gln Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser 
        275                 280                 285             


Pro Ala Pro Pro Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly 
    290                 295                 300                 


Pro Ser Val Pro Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln 
305                 310                 315                 320 


Leu Gln Gln Lys Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly 
                325                 330                 335     


Leu Asp Pro Val Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala 
            340                 345                 350         


Arg Ile Ala His Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu 
        355                 360                 365             


Pro Pro Asp Leu Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg 
    370                 375                 380                 


Leu Leu Asn Phe Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met 
385                 390                 395                 400 


Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys 
                405                 410                 415     


Arg Ser Lys Arg Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu 
            420                 425                 430         


Glu Lys Gln Gln Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His 
        435                 440                 445             


Gln Glu Tyr Leu Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu 
    450                 455                 460                 


Tyr His Arg Ser Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val 
465                 470                 475                 480 


Ala Thr Trp His Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu 
                485                 490                 495     


Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu 
            500                 505                 510         


Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr 
        515                 520                 525             


Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val 
    530                 535                 540                 


Trp Glu His Lys Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg 
545                 550                 555                 560 


Arg Arg Lys Lys Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala 
                565                 570                 575     


Leu Gly Pro Asp Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp 
            580                 585                 590         


Leu Pro Val Lys Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly 
        595                 600                 605             


Pro Glu Ala Pro Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn 
    610                 615                 620                 


Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser 
625                 630                 635                 640 


Asp Tyr Glu Glu Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr 
                645                 650                 655     


Glu Glu Lys Ile Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys 
            660                 665                 670         


Asp Ala Lys Gln Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu 
        675                 680                 685             


Tyr Ser Met Gln Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val 
    690                 695                 700                 


Ala His Ala Ile Ser Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile 
705                 710                 715                 720 


Asn Gly Thr Leu Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val 
                725                 730                 735     


Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly 
            740                 745                 750         


Leu Gly Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu 
        755                 760                 765             


His Lys Arg Leu Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr 
    770                 775                 780                 


Leu Ser Asn Trp Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val 
785                 790                 795                 800 


Lys Ile Ser Tyr Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro 
                805                 810                 815     


Gln Leu Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr 
            820                 825                 830         


Ile Ile Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met 
        835                 840                 845             


Ile Val Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr 
    850                 855                 860                 


Gln Val Leu Asn Thr His Tyr Val Ala Pro Arg Arg Ile Leu Leu Thr 
865                 870                 875                 880 


Gly Thr Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn 
                885                 890                 895     


Phe Leu Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp 
            900                 905                 910         


Phe Asn Ala Pro Phe Ala Met Thr Gly Glu Arg Val Asp Leu Asn Glu 
        915                 920                 925             


Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro 
    930                 935                 940                 


Phe Leu Leu Arg Arg Leu Lys Lys Glu Val Glu Ser Gln Leu Pro Glu 
945                 950                 955                 960 


Lys Val Glu Tyr Val Ile Lys Cys Asp Met Ser Ala Leu Gln Lys Ile 
                965                 970                 975     


Leu Tyr Arg His Met Gln Ala Lys Gly Ile Leu Leu Thr Asp Gly Ser 
            980                 985                 990         


Glu Lys Asp Lys Lys Gly Lys Gly  Gly Ala Lys Thr Leu  Met Asn Thr 
        995                 1000                 1005             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1010                 1015                 1020             


His Ile  Glu Glu Ser Phe Ala  Glu His Leu Gly Tyr  Ser Asn Gly 
    1025                 1030                 1035             


Val Ile  Asn Gly Ala Glu Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1040                 1045                 1050             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Arg 
    1055                 1060                 1065             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1070                 1075                 1080             


Asp Tyr  Phe Ala Phe Arg Asn  Phe Leu Tyr Leu Arg  Leu Asp Gly 
    1085                 1090                 1095             


Thr Thr  Lys Ser Glu Asp Arg  Ala Ala Leu Leu Lys  Lys Phe Asn 
    1100                 1105                 1110             


Glu Pro  Gly Ser Gln Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ala Ala Asp Thr  Val Val Ile 
    1130                 1135                 1140             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1160                 1165                 1170             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1175                 1180                 1185             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1190                 1195                 1200             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1205                 1210                 1215             


Ala Ile  Leu Glu His Glu Glu  Glu Asn Glu Glu Glu  Asp Glu Val 
    1220                 1225                 1230             


Pro Asp  Asp Glu Thr Leu Asn  Gln Met Ile Ala Arg  Arg Glu Glu 
    1235                 1240                 1245             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Met Asp Arg  Arg Arg Glu 
    1250                 1255                 1260             


Asp Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1265                 1270                 1275             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1280                 1285                 1290             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Ile Phe Gly  Arg Gly Ser 
    1295                 1300                 1305             


Arg Gln  Arg Arg Asp Val Asp  Tyr Ser Asp Ala Leu  Thr Glu Lys 
    1310                 1315                 1320             


Gln Trp  Leu Arg Ala Ile Glu  Asp Gly Asn Leu Glu  Glu Met Glu 
    1325                 1330                 1335             


Glu Glu  Val Arg Leu Lys Lys  Arg Lys Arg Arg Arg  Asn Val Asp 
    1340                 1345                 1350             


Lys Asp  Pro Ala Lys Glu Asp  Val Glu Lys Ala Lys  Lys Arg Arg 
    1355                 1360                 1365             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Lys Leu 
    1370                 1375                 1380             


Thr Lys  Gln Met Asn Ala Ile  Ile Asp Thr Val Ile  Asn Tyr Lys 
    1385                 1390                 1395             


Asp Arg  Cys Asn Val Glu Lys  Val Pro Ser Asn Ser  Gln Leu Glu 
    1400                 1405                 1410             


Ile Glu  Gly Asn Ser Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile 
    1415                 1420                 1425             


Gln Leu  Pro Ser Arg Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile 
    1430                 1435                 1440             


Arg Lys  Pro Val Asp Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn 
    1445                 1450                 1455             


His Lys  Tyr Arg Ser Leu Gly  Asp Leu Glu Lys Asp  Val Met Leu 
    1460                 1465                 1470             


Leu Cys  His Asn Ala Gln Thr  Phe Asn Leu Glu Gly  Ser Gln Ile 
    1475                 1480                 1485             


Tyr Glu  Asp Ser Ile Val Leu  Gln Ser Val Phe Lys  Ser Ala Arg 
    1490                 1495                 1500             


Gln Lys  Ile Ala Lys Glu Glu  Glu Ser Glu Asp Glu  Ser Asn Glu 
    1505                 1510                 1515             


Glu Glu  Glu Glu Glu Asp Glu  Glu Glu Ser Glu Ser  Glu Ala Lys 
    1520                 1525                 1530             


Ser Val  Lys Val Lys Ile Lys  Leu Asn Lys Lys Asp  Asp Lys Gly 
    1535                 1540                 1545             


Arg Asp  Lys Gly Lys Gly Lys  Lys Arg Pro Asn Arg  Gly Lys Ala 
    1550                 1555                 1560             


Lys Pro  Val Val Ser Asp Phe  Asp Ser Asp Glu Glu  Gln Asp Glu 
    1565                 1570                 1575             


Arg Glu  Gln Ser Glu Gly Ser  Gly Thr Asp Asp Glu  
    1580                 1585                 1590 


<210> 240
<211> 2236
<212> PRT
<213> Homo sapiens

<400> 240
Met Ala His Asn Ala Gly Ala Ala Ala Ala Ala Gly Thr His Ser Ala 
1               5                   10                  15      


Lys Ser Gly Gly Ser Glu Ala Ala Leu Lys Glu Gly Gly Ser Ala Ala 
            20                  25                  30          


Ala Leu Ser Ser Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala Ala Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Gly Pro Gly Ser Ala Met Glu Thr Gly Leu Leu 
    50                  55                  60                  


Pro Asn His Lys Leu Lys Thr Val Gly Glu Ala Pro Ala Ala Pro Pro 
65                  70                  75                  80  


His Gln Gln His His His His His His Ala His His His His His His 
                85                  90                  95      


Ala His His Leu His His His His Ala Leu Gln Gln Gln Leu Asn Gln 
            100                 105                 110         


Phe Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        115                 120                 125             


Gln Gln Gln His Pro Ile Ser Asn Asn Asn Ser Leu Gly Gly Ala Gly 
    130                 135                 140                 


Gly Gly Ala Pro Gln Pro Gly Pro Asp Met Glu Gln Pro Gln His Gly 
145                 150                 155                 160 


Gly Ala Lys Asp Ser Ala Ala Gly Gly Gln Ala Asp Pro Pro Gly Pro 
                165                 170                 175     


Pro Leu Leu Ser Lys Pro Gly Asp Glu Asp Asp Ala Pro Pro Lys Met 
            180                 185                 190         


Gly Glu Pro Ala Gly Gly Arg Tyr Glu His Pro Gly Leu Gly Ala Leu 
        195                 200                 205             


Gly Thr Gln Gln Pro Pro Val Ala Val Pro Gly Gly Gly Gly Gly Pro 
    210                 215                 220                 


Ala Ala Val Pro Glu Phe Asn Asn Tyr Tyr Gly Ser Ala Ala Pro Ala 
225                 230                 235                 240 


Ser Gly Gly Pro Gly Gly Arg Ala Gly Pro Cys Phe Asp Gln His Gly 
                245                 250                 255     


Gly Gln Gln Ser Pro Gly Met Gly Met Met His Ser Ala Ser Ala Ala 
            260                 265                 270         


Ala Ala Gly Ala Pro Gly Ser Met Asp Pro Leu Gln Asn Ser His Glu 
        275                 280                 285             


Gly Tyr Pro Asn Ser Gln Cys Asn His Tyr Pro Gly Tyr Ser Arg Pro 
    290                 295                 300                 


Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Ala Gly Ala Gly Gly Ala Gly Ala 
                325                 330                 335     


Gly Ala Val Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser Ala Gly Tyr Gly Val Leu 
        355                 360                 365             


Ser Ser Pro Arg Gln Gln Gly Gly Gly Met Met Met Gly Pro Gly Gly 
    370                 375                 380                 


Gly Gly Ala Ala Ser Leu Ser Lys Ala Ala Ala Gly Ser Ala Ala Gly 
385                 390                 395                 400 


Gly Phe Gln Arg Phe Ala Gly Gln Asn Gln His Pro Ser Gly Ala Thr 
                405                 410                 415     


Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Pro Met Met Arg Ser 
            420                 425                 430         


Tyr Gly Gly Ser Tyr Pro Glu Tyr Ser Ser Pro Ser Ala Pro Pro Pro 
        435                 440                 445             


Pro Pro Ser Gln Pro Gln Ser Gln Ala Ala Ala Ala Gly Ala Ala Ala 
    450                 455                 460                 


Gly Gly Gln Gln Ala Ala Ala Gly Met Gly Leu Gly Lys Asp Met Gly 
465                 470                 475                 480 


Ala Gln Tyr Ala Ala Ala Ser Pro Ala Trp Ala Ala Ala Gln Gln Arg 
                485                 490                 495     


Ser His Pro Ala Met Ser Pro Gly Thr Pro Gly Pro Thr Met Gly Arg 
            500                 505                 510         


Ser Gln Gly Ser Pro Met Asp Pro Met Val Met Lys Arg Pro Gln Leu 
        515                 520                 525             


Tyr Gly Met Gly Ser Asn Pro His Ser Gln Pro Gln Gln Ser Ser Pro 
    530                 535                 540                 


Tyr Pro Gly Gly Ser Tyr Gly Pro Pro Gly Pro Gln Arg Tyr Pro Ile 
545                 550                 555                 560 


Gly Ile Gln Gly Arg Thr Pro Gly Ala Met Ala Gly Met Gln Tyr Pro 
                565                 570                 575     


Gln Gln Gln Met Pro Pro Gln Tyr Gly Gln Gln Gly Val Ser Gly Tyr 
            580                 585                 590         


Cys Gln Gln Gly Gln Gln Pro Tyr Tyr Ser Gln Gln Pro Gln Pro Pro 
        595                 600                 605             


His Leu Pro Pro Gln Ala Gln Tyr Leu Pro Ser Gln Ser Gln Gln Arg 
    610                 615                 620                 


Tyr Gln Pro Gln Gln Asp Met Ser Gln Glu Gly Tyr Gly Thr Arg Ser 
625                 630                 635                 640 


Gln Pro Pro Leu Ala Pro Gly Lys Pro Asn His Glu Asp Leu Asn Leu 
                645                 650                 655     


Ile Gln Gln Glu Arg Pro Ser Ser Leu Pro Asp Leu Ser Gly Ser Ile 
            660                 665                 670         


Asp Asp Leu Pro Thr Gly Thr Glu Ala Thr Leu Ser Ser Ala Val Ser 
        675                 680                 685             


Ala Ser Gly Ser Thr Ser Ser Gln Gly Asp Gln Ser Asn Pro Ala Gln 
    690                 695                 700                 


Ser Pro Phe Ser Pro His Ala Ser Pro His Leu Ser Ser Ile Pro Gly 
705                 710                 715                 720 


Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Val Gly Ser Asn Gln Ser 
                725                 730                 735     


Arg Ser Gly Pro Ile Ser Pro Ala Ser Ile Pro Gly Ser Gln Met Pro 
            740                 745                 750         


Pro Gln Pro Pro Gly Ser Gln Ser Glu Ser Ser Ser His Pro Ala Leu 
        755                 760                 765             


Ser Gln Ser Pro Met Pro Gln Glu Arg Gly Phe Met Ala Gly Thr Gln 
    770                 775                 780                 


Arg Asn Pro Gln Met Ala Gln Tyr Gly Pro Gln Gln Thr Gly Pro Ser 
785                 790                 795                 800 


Met Ser Pro His Pro Ser Pro Gly Gly Gln Met His Ala Gly Ile Ser 
                805                 810                 815     


Ser Phe Gln Gln Ser Asn Ser Ser Gly Thr Tyr Gly Pro Gln Met Ser 
            820                 825                 830         


Gln Tyr Gly Pro Gln Gly Asn Tyr Ser Arg Pro Pro Ala Tyr Ser Gly 
        835                 840                 845             


Val Pro Ser Ala Ser Tyr Ser Gly Pro Gly Pro Gly Met Gly Ile Ser 
    850                 855                 860                 


Ala Asn Asn Gln Met His Gly Gln Gly Pro Ser Gln Pro Cys Gly Ala 
865                 870                 875                 880 


Val Pro Leu Gly Arg Met Pro Ser Ala Gly Met Gln Asn Arg Pro Phe 
                885                 890                 895     


Pro Gly Asn Met Ser Ser Met Thr Pro Ser Ser Pro Gly Met Ser Gln 
            900                 905                 910         


Gln Gly Gly Pro Gly Met Gly Pro Pro Met Pro Thr Val Asn Arg Lys 
        915                 920                 925             


Ala Gln Glu Ala Ala Ala Ala Val Met Gln Ala Ala Ala Asn Ser Ala 
    930                 935                 940                 


Gln Ser Arg Gln Gly Ser Phe Pro Gly Met Asn Gln Ser Gly Leu Met 
945                 950                 955                 960 


Ala Ser Ser Ser Pro Tyr Ser Gln Pro Met Asn Asn Ser Ser Ser Leu 
                965                 970                 975     


Met Asn Thr Gln Ala Pro Pro Tyr Ser Met Ala Pro Ala Met Val Asn 
            980                 985                 990         


Ser Ser Ala Ala Ser Val Gly Leu  Ala Asp Met Met Ser  Pro Gly Glu 
        995                 1000                 1005             


Ser Lys  Leu Pro Leu Pro Leu  Lys Ala Asp Gly Lys  Glu Glu Gly 
    1010                 1015                 1020             


Thr Pro  Gln Pro Glu Ser Lys  Ser Lys Lys Ser Ser  Ser Ser Thr 
    1025                 1030                 1035             


Thr Thr  Gly Glu Lys Ile Thr  Lys Val Tyr Glu Leu  Gly Asn Glu 
    1040                 1045                 1050             


Pro Glu  Arg Lys Leu Trp Val  Asp Arg Tyr Leu Thr  Phe Met Glu 
    1055                 1060                 1065             


Glu Arg  Gly Ser Pro Val Ser  Ser Leu Pro Ala Val  Gly Lys Lys 
    1070                 1075                 1080             


Pro Leu  Asp Leu Phe Arg Leu  Tyr Val Cys Val Lys  Glu Ile Gly 
    1085                 1090                 1095             


Gly Leu  Ala Gln Val Asn Lys  Asn Lys Lys Trp Arg  Glu Leu Ala 
    1100                 1105                 1110             


Thr Asn  Leu Asn Val Gly Thr  Ser Ser Ser Ala Ala  Ser Ser Leu 
    1115                 1120                 1125             


Lys Lys  Gln Tyr Ile Gln Tyr  Leu Phe Ala Phe Glu  Cys Lys Ile 
    1130                 1135                 1140             


Glu Arg  Gly Glu Glu Pro Pro  Pro Glu Val Phe Ser  Thr Gly Asp 
    1145                 1150                 1155             


Thr Lys  Lys Gln Pro Lys Leu  Gln Pro Pro Ser Pro  Ala Asn Ser 
    1160                 1165                 1170             


Gly Ser  Leu Gln Gly Pro Gln  Thr Pro Gln Ser Thr  Gly Ser Asn 
    1175                 1180                 1185             


Ser Met  Ala Glu Val Pro Gly  Asp Leu Lys Pro Pro  Thr Pro Ala 
    1190                 1195                 1200             


Ser Thr  Pro His Gly Gln Met  Thr Pro Met Gln Gly  Gly Arg Ser 
    1205                 1210                 1215             


Ser Thr  Ile Ser Val His Asp  Pro Phe Ser Asp Val  Ser Asp Ser 
    1220                 1225                 1230             


Ser Phe  Pro Lys Arg Asn Ser  Met Thr Pro Asn Ala  Pro Tyr Gln 
    1235                 1240                 1245             


Gln Gly  Met Ser Met Pro Asp  Val Met Gly Arg Met  Pro Tyr Glu 
    1250                 1255                 1260             


Pro Asn  Lys Asp Pro Phe Gly  Gly Met Arg Lys Val  Pro Gly Ser 
    1265                 1270                 1275             


Ser Glu  Pro Phe Met Thr Gln  Gly Gln Met Pro Asn  Ser Ser Met 
    1280                 1285                 1290             


Gln Asp  Met Tyr Asn Gln Ser  Pro Ser Gly Ala Met  Ser Asn Leu 
    1295                 1300                 1305             


Gly Met  Gly Gln Arg Gln Gln  Phe Pro Tyr Gly Ala  Ser Tyr Asp 
    1310                 1315                 1320             


Arg Arg  His Glu Pro Tyr Gly  Gln Gln Tyr Pro Gly  Gln Gly Pro 
    1325                 1330                 1335             


Pro Ser  Gly Gln Pro Pro Tyr  Gly Gly His Gln Pro  Gly Leu Tyr 
    1340                 1345                 1350             


Pro Gln  Gln Pro Asn Tyr Lys  Arg His Met Asp Gly  Met Tyr Gly 
    1355                 1360                 1365             


Pro Pro  Ala Lys Arg His Glu  Gly Asp Met Tyr Asn  Met Gln Tyr 
    1370                 1375                 1380             


Ser Ser  Gln Gln Gln Glu Met  Tyr Asn Gln Tyr Gly  Gly Ser Tyr 
    1385                 1390                 1395             


Ser Gly  Pro Asp Arg Arg Pro  Ile Gln Gly Gln Tyr  Pro Tyr Pro 
    1400                 1405                 1410             


Tyr Ser  Arg Glu Arg Met Gln  Gly Pro Gly Gln Ile  Gln Thr His 
    1415                 1420                 1425             


Gly Ile  Pro Pro Gln Met Met  Gly Gly Pro Leu Gln  Ser Ser Ser 
    1430                 1435                 1440             


Ser Glu  Gly Pro Gln Gln Asn  Met Trp Ala Ala Arg  Asn Asp Met 
    1445                 1450                 1455             


Pro Tyr  Pro Tyr Gln Asn Arg  Gln Gly Pro Gly Gly  Pro Thr Gln 
    1460                 1465                 1470             


Ala Pro  Pro Tyr Pro Gly Met  Asn Arg Thr Asp Asp  Met Met Val 
    1475                 1480                 1485             


Pro Asp  Gln Arg Ile Asn His  Glu Ser Gln Trp Pro  Ser His Val 
    1490                 1495                 1500             


Ser Gln  Arg Gln Pro Tyr Met  Ser Ser Ser Ala Ser  Met Gln Pro 
    1505                 1510                 1515             


Ile Thr  Arg Pro Pro Gln Pro  Ser Tyr Gln Thr Pro  Pro Ser Leu 
    1520                 1525                 1530             


Pro Asn  His Ile Ser Arg Ala  Pro Ser Pro Ala Ser  Phe Gln Arg 
    1535                 1540                 1545             


Ser Leu  Glu Asn Arg Met Ser  Pro Ser Lys Ser Pro  Phe Leu Pro 
    1550                 1555                 1560             


Ser Met  Lys Met Gln Lys Val  Met Pro Thr Val Pro  Thr Ser Gln 
    1565                 1570                 1575             


Val Thr  Gly Pro Pro Pro Gln  Pro Pro Pro Ile Arg  Arg Glu Ile 
    1580                 1585                 1590             


Thr Phe  Pro Pro Gly Ser Val  Glu Ala Ser Gln Pro  Val Leu Lys 
    1595                 1600                 1605             


Gln Arg  Arg Lys Ile Thr Ser  Lys Asp Ile Val Thr  Pro Glu Ala 
    1610                 1615                 1620             


Trp Arg  Val Met Met Ser Leu  Lys Ser Gly Leu Leu  Ala Glu Ser 
    1625                 1630                 1635             


Thr Trp  Ala Leu Asp Thr Ile  Asn Ile Leu Leu Tyr  Asp Asp Ser 
    1640                 1645                 1650             


Thr Val  Ala Thr Phe Asn Leu  Ser Gln Leu Ser Gly  Phe Leu Glu 
    1655                 1660                 1665             


Leu Leu  Val Glu Tyr Phe Arg  Lys Cys Leu Ile Asp  Ile Phe Gly 
    1670                 1675                 1680             


Ile Leu  Met Glu Tyr Glu Val  Gly Asp Pro Ser Gln  Lys Ala Leu 
    1685                 1690                 1695             


Asp His  Asn Ala Ala Arg Lys  Asp Asp Ser Gln Ser  Leu Ala Asp 
    1700                 1705                 1710             


Asp Ser  Gly Lys Glu Glu Glu  Asp Ala Glu Cys Ile  Asp Asp Asp 
    1715                 1720                 1725             


Glu Glu  Asp Glu Glu Asp Glu  Glu Glu Asp Ser Glu  Lys Thr Glu 
    1730                 1735                 1740             


Ser Asp  Glu Lys Ser Ser Ile  Ala Leu Thr Ala Pro  Asp Ala Ala 
    1745                 1750                 1755             


Ala Asp  Pro Lys Glu Lys Pro  Lys Gln Ala Ser Lys  Phe Asp Lys 
    1760                 1765                 1770             


Leu Pro  Ile Lys Ile Val Lys  Lys Asn Asn Leu Phe  Val Val Asp 
    1775                 1780                 1785             


Arg Ser  Asp Lys Leu Gly Arg  Val Gln Glu Phe Asn  Ser Gly Leu 
    1790                 1795                 1800             


Leu His  Trp Gln Leu Gly Gly  Gly Asp Thr Thr Glu  His Ile Gln 
    1805                 1810                 1815             


Thr His  Phe Glu Ser Lys Met  Glu Ile Pro Pro Arg  Arg Arg Pro 
    1820                 1825                 1830             


Pro Pro  Pro Leu Ser Ser Ala  Gly Arg Lys Lys Glu  Gln Glu Gly 
    1835                 1840                 1845             


Lys Gly  Asp Ser Glu Glu Gln  Gln Glu Lys Ser Ile  Ile Ala Thr 
    1850                 1855                 1860             


Ile Asp  Asp Val Leu Ser Ala  Arg Pro Gly Ala Leu  Pro Glu Asp 
    1865                 1870                 1875             


Ala Asn  Pro Gly Pro Gln Thr  Glu Ser Ser Lys Phe  Pro Phe Gly 
    1880                 1885                 1890             


Ile Gln  Gln Ala Lys Ser His  Arg Asn Ile Lys Leu  Leu Glu Asp 
    1895                 1900                 1905             


Glu Pro  Arg Ser Arg Asp Glu  Thr Pro Leu Cys Thr  Ile Ala His 
    1910                 1915                 1920             


Trp Gln  Asp Ser Leu Ala Lys  Arg Cys Ile Cys Val  Ser Asn Ile 
    1925                 1930                 1935             


Val Arg  Ser Leu Ser Phe Val  Pro Gly Asn Asp Ala  Glu Met Ser 
    1940                 1945                 1950             


Lys His  Pro Gly Leu Val Leu  Ile Leu Gly Lys Leu  Ile Leu Leu 
    1955                 1960                 1965             


His His  Glu His Pro Glu Arg  Lys Arg Ala Pro Gln  Thr Tyr Glu 
    1970                 1975                 1980             


Lys Glu  Glu Asp Glu Asp Lys  Gly Val Ala Cys Ser  Lys Asp Glu 
    1985                 1990                 1995             


Trp Trp  Trp Asp Cys Leu Glu  Val Leu Arg Asp Asn  Thr Leu Val 
    2000                 2005                 2010             


Thr Leu  Ala Asn Ile Ser Gly  Gln Leu Asp Leu Ser  Ala Tyr Thr 
    2015                 2020                 2025             


Glu Ser  Ile Cys Leu Pro Ile  Leu Asp Gly Leu Leu  His Trp Met 
    2030                 2035                 2040             


Val Cys  Pro Ser Ala Glu Ala  Gln Asp Pro Phe Pro  Thr Val Gly 
    2045                 2050                 2055             


Pro Asn  Ser Val Leu Ser Pro  Gln Arg Leu Val Leu  Glu Thr Leu 
    2060                 2065                 2070             


Cys Lys  Leu Ser Ile Gln Asp  Asn Asn Val Asp Leu  Ile Leu Ala 
    2075                 2080                 2085             


Thr Pro  Pro Phe Ser Arg Gln  Glu Lys Phe Tyr Ala  Thr Leu Val 
    2090                 2095                 2100             


Arg Tyr  Val Gly Asp Arg Lys  Asn Pro Val Cys Arg  Glu Met Ser 
    2105                 2110                 2115             


Met Ala  Leu Leu Ser Asn Leu  Ala Gln Gly Asp Ala  Leu Ala Ala 
    2120                 2125                 2130             


Arg Ala  Ile Ala Val Gln Lys  Gly Ser Ile Gly Asn  Leu Ile Ser 
    2135                 2140                 2145             


Phe Leu  Glu Asp Gly Val Thr  Met Ala Gln Tyr Gln  Gln Ser Gln 
    2150                 2155                 2160             


His Asn  Leu Met His Met Gln  Pro Pro Pro Leu Glu  Pro Pro Ser 
    2165                 2170                 2175             


Val Asp  Met Met Cys Arg Ala  Ala Lys Ala Leu Leu  Ala Met Ala 
    2180                 2185                 2190             


Arg Val  Asp Glu Asn Arg Ser  Glu Phe Leu Leu His  Glu Gly Arg 
    2195                 2200                 2205             


Leu Leu  Asp Ile Ser Ile Ser  Ala Val Leu Asn Ser  Leu Val Ala 
    2210                 2215                 2220             


Ser Val  Ile Cys Asp Val Leu  Phe Gln Ile Gly Gln  Leu 
    2225                 2230                 2235     


<210> 241
<211> 1410
<212> PRT
<213> Homo sapiens

<400> 241
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Gly 
                85                  90                  95      


Asn Pro Leu Val Gln Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn 
            100                 105                 110         


Pro Ala Pro Gly Leu Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro 
        115                 120                 125             


Val Gln Val Met Gln Asn Ala Asn His Val Thr Ser Ser Pro Val Ala 
    130                 135                 140                 


Ser Gln Pro Ile Phe Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val 
145                 150                 155                 160 


Arg Pro Val Gln Asn Ala Met Asn Gln Val Gly Ile Val Leu Asn Val 
                165                 170                 175     


Gln Gln Gly Gln Thr Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly 
            180                 185                 190         


Thr Gln Phe Val Lys Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln 
        195                 200                 205             


Met Thr Pro Val Arg Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr 
    210                 215                 220                 


Asn Thr Phe Thr Thr Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr 
225                 230                 235                 240 


Val Pro Gln Ser Gln Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser 
                245                 250                 255     


Thr Thr Pro Thr Ala Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val 
            260                 265                 270         


Gln Ser Pro Gly Gln Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala Pro 
        275                 280                 285             


Ser Phe Pro Ser Pro Pro Ala Val Ser Ile Ala Ser Phe Val Thr Val 
    290                 295                 300                 


Lys Arg Pro Gly Val Thr Gly Glu Asn Ser Asn Glu Val Ala Lys Leu 
305                 310                 315                 320 


Val Asn Thr Leu Asn Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly Pro 
                325                 330                 335     


Val Val Val Ser Asn Asn Ser Ser Ala His Gly Ser Gln Arg Thr Ser 
            340                 345                 350         


Gly Pro Glu Ser Ser Met Lys Val Thr Ser Ser Ile Pro Val Phe Asp 
        355                 360                 365             


Leu Gln Asp Gly Gly Arg Lys Ile Cys Pro Arg Cys Asn Ala Gln Phe 
    370                 375                 380                 


Arg Val Thr Glu Ala Leu Arg Gly His Met Cys Tyr Cys Cys Pro Glu 
385                 390                 395                 400 


Met Val Glu Tyr Gln Lys Lys Gly Lys Ser Leu Asp Ser Glu Pro Ser 
                405                 410                 415     


Val Pro Ser Ala Ala Lys Pro Pro Ser Pro Glu Lys Thr Ala Pro Val 
            420                 425                 430         


Ala Ser Thr Pro Ser Ser Thr Pro Ile Pro Ala Leu Ser Pro Pro Thr 
        435                 440                 445             


Lys Val Pro Glu Pro Asn Glu Asn Val Gly Asp Ala Val Gln Thr Lys 
    450                 455                 460                 


Leu Ile Met Leu Val Asp Asp Phe Tyr Tyr Gly Arg Asp Gly Gly Lys 
465                 470                 475                 480 


Val Ala Gln Leu Thr Asn Phe Pro Lys Val Ala Thr Ser Phe Arg Cys 
                485                 490                 495     


Pro His Cys Thr Lys Arg Leu Lys Asn Asn Ile Arg Phe Met Asn His 
            500                 505                 510         


Met Lys His His Val Glu Leu Asp Gln Gln Asn Gly Glu Val Asp Gly 
        515                 520                 525             


His Thr Ile Cys Gln His Cys Tyr Arg Gln Phe Ser Thr Pro Phe Gln 
    530                 535                 540                 


Leu Gln Cys His Leu Glu Asn Val His Ser Pro Tyr Glu Ser Thr Thr 
545                 550                 555                 560 


Lys Cys Lys Ile Cys Glu Trp Ala Phe Glu Ser Glu Pro Leu Phe Leu 
                565                 570                 575     


Gln His Met Lys Asp Thr His Lys Pro Gly Glu Met Pro Tyr Val Cys 
            580                 585                 590         


Gln Val Cys Gln Tyr Arg Ser Ser Leu Tyr Ser Glu Val Asp Val His 
        595                 600                 605             


Phe Arg Met Ile His Glu Asp Thr Arg His Leu Leu Cys Pro Tyr Cys 
    610                 615                 620                 


Leu Lys Val Phe Lys Asn Gly Asn Ala Phe Gln Gln His Tyr Met Arg 
625                 630                 635                 640 


His Gln Lys Arg Asn Val Tyr His Cys Asn Lys Cys Arg Leu Gln Phe 
                645                 650                 655     


Leu Phe Ala Lys Asp Lys Ile Glu His Lys Leu Gln His His Lys Thr 
            660                 665                 670         


Phe Arg Lys Pro Lys Gln Leu Glu Gly Leu Lys Pro Gly Thr Lys Val 
        675                 680                 685             


Thr Ile Arg Ala Ser Arg Gly Gln Pro Arg Thr Val Pro Val Ser Ser 
    690                 695                 700                 


Asn Asp Thr Pro Pro Ser Ala Leu Gln Glu Ala Ala Pro Leu Thr Ser 
705                 710                 715                 720 


Ser Met Asp Pro Leu Pro Val Phe Leu Tyr Pro Pro Val Gln Arg Ser 
                725                 730                 735     


Ile Gln Lys Arg Ala Val Arg Lys Met Ser Val Met Gly Arg Gln Thr 
            740                 745                 750         


Cys Leu Glu Cys Ser Phe Glu Ile Pro Asp Phe Pro Asn His Phe Pro 
        755                 760                 765             


Thr Tyr Val His Cys Ser Leu Cys Arg Tyr Ser Thr Cys Cys Ser Arg 
    770                 775                 780                 


Ala Tyr Ala Asn His Met Ile Asn Asn His Val Pro Arg Lys Ser Pro 
785                 790                 795                 800 


Lys Tyr Leu Ala Leu Phe Lys Asn Ser Val Ser Gly Ile Lys Leu Ala 
                805                 810                 815     


Cys Thr Ser Cys Thr Phe Val Thr Ser Val Gly Asp Ala Met Ala Lys 
            820                 825                 830         


His Leu Val Phe Asn Pro Ser His Arg Ser Ser Ser Ile Leu Pro Arg 
        835                 840                 845             


Gly Leu Thr Trp Ile Ala His Ser Arg His Gly Gln Thr Arg Asp Arg 
    850                 855                 860                 


Val His Asp Arg Asn Val Lys Asn Met Tyr Pro Pro Pro Ser Phe Pro 
865                 870                 875                 880 


Thr Asn Lys Ala Ala Thr Val Lys Ser Ala Gly Ala Thr Pro Ala Glu 
                885                 890                 895     


Pro Glu Glu Leu Leu Thr Pro Leu Ala Pro Ala Leu Pro Ser Pro Ala 
            900                 905                 910         


Ser Thr Ala Thr Pro Pro Pro Thr Pro Thr His Pro Gln Ala Leu Ala 
        915                 920                 925             


Leu Pro Pro Leu Ala Thr Glu Gly Ala Glu Cys Leu Asn Val Asp Asp 
    930                 935                 940                 


Gln Asp Glu Gly Ser Pro Val Thr Gln Glu Pro Glu Leu Ala Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser Gly Gly Val Gly Lys Lys Glu Gln Leu Ser Val Lys 
                965                 970                 975     


Lys Leu Arg Val Val Leu Phe Ala Leu Cys Cys Asn Thr Glu Gln Ala 
            980                 985                 990         


Ala Glu His Phe Arg Asn Pro Gln  Arg Arg Ile Arg Arg  Trp Leu Arg 
        995                 1000                 1005             


Arg Phe  Gln Ala Ser Gln Gly  Glu Asn Leu Glu Gly  Lys Tyr Leu 
    1010                 1015                 1020             


Ser Phe  Glu Ala Glu Glu Lys  Leu Ala Glu Trp Val  Leu Thr Gln 
    1025                 1030                 1035             


Arg Glu  Gln Gln Leu Pro Val  Asn Glu Glu Thr Leu  Phe Gln Lys 
    1040                 1045                 1050             


Ala Thr  Lys Ile Gly Arg Ser  Leu Glu Gly Gly Phe  Lys Ile Ser 
    1055                 1060                 1065             


Tyr Glu  Trp Ala Val Arg Phe  Met Leu Arg His His  Leu Thr Pro 
    1070                 1075                 1080             


His Ala  Arg Arg Ala Val Ala  His Thr Leu Pro Lys  Asp Val Ala 
    1085                 1090                 1095             


Glu Asn  Ala Gly Leu Phe Ile  Asp Phe Val Gln Arg  Gln Ile His 
    1100                 1105                 1110             


Asn Gln  Asp Leu Pro Leu Ser  Met Ile Val Ala Ile  Asp Glu Ile 
    1115                 1120                 1125             


Ser Leu  Phe Leu Asp Thr Glu  Val Leu Ser Ser Asp  Asp Arg Lys 
    1130                 1135                 1140             


Glu Asn  Ala Leu Gln Thr Val  Gly Thr Gly Glu Pro  Trp Cys Asp 
    1145                 1150                 1155             


Val Val  Leu Ala Ile Leu Ala  Asp Gly Thr Val Leu  Pro Thr Leu 
    1160                 1165                 1170             


Val Phe  Tyr Arg Gly Gln Met  Asp Gln Pro Ala Asn  Met Pro Asp 
    1175                 1180                 1185             


Ser Ile  Leu Leu Glu Ala Lys  Glu Ser Gly Tyr Ser  Asp Asp Glu 
    1190                 1195                 1200             


Ile Met  Glu Leu Trp Ser Thr  Arg Val Trp Gln Lys  His Thr Ala 
    1205                 1210                 1215             


Cys Gln  Arg Ser Lys Gly Met  Leu Val Met Asp Cys  His Arg Thr 
    1220                 1225                 1230             


His Leu  Ser Glu Glu Val Leu  Ala Met Leu Ser Ala  Ser Ser Thr 
    1235                 1240                 1245             


Leu Pro  Ala Val Val Pro Ala  Gly Cys Ser Ser Lys  Ile Gln Pro 
    1250                 1255                 1260             


Leu Asp  Val Cys Ile Lys Arg  Thr Val Lys Asn Phe  Leu His Lys 
    1265                 1270                 1275             


Lys Trp  Lys Glu Gln Ala Arg  Glu Met Ala Asp Thr  Ala Cys Asp 
    1280                 1285                 1290             


Ser Asp  Val Leu Leu Gln Leu  Val Leu Val Trp Leu  Gly Glu Val 
    1295                 1300                 1305             


Leu Gly  Val Ile Gly Asp Cys  Pro Glu Leu Val Gln  Arg Ser Phe 
    1310                 1315                 1320             


Leu Val  Ala Ser Val Leu Pro  Gly Pro Asp Gly Asn  Ile Asn Ser 
    1325                 1330                 1335             


Pro Thr  Arg Asn Ala Asp Met  Gln Glu Glu Leu Ile  Ala Ser Leu 
    1340                 1345                 1350             


Glu Glu  Gln Leu Lys Leu Ser  Gly Glu His Ser Glu  Ser Ser Thr 
    1355                 1360                 1365             


Pro Arg  Pro Arg Ser Ser Pro  Glu Glu Thr Ile Glu  Pro Glu Ser 
    1370                 1375                 1380             


Leu His  Gln Leu Phe Glu Gly  Glu Ser Glu Thr Glu  Ser Phe Tyr 
    1385                 1390                 1395             


Gly Phe  Glu Glu Ala Asp Leu  Asp Leu Met Glu Ile  
    1400                 1405                 1410 


<210> 242
<211> 1410
<212> PRT
<213> Homo sapiens

<400> 242
Met Ala Asp Thr Asp Leu Phe Met Glu Cys Glu Glu Glu Glu Leu Glu 
1               5                   10                  15      


Pro Trp Gln Lys Ile Ser Asp Val Ile Glu Asp Ser Val Val Glu Asp 
            20                  25                  30          


Tyr Asn Ser Val Asp Lys Thr Thr Thr Val Ser Val Ser Gln Gln Pro 
        35                  40                  45              


Val Ser Ala Pro Val Pro Ile Ala Ala His Ala Ser Val Ala Gly His 
    50                  55                  60                  


Leu Ser Thr Ser Thr Thr Val Ser Ser Ser Gly Ala Gln Asn Ser Asp 
65                  70                  75                  80  


Ser Thr Lys Lys Thr Leu Val Thr Leu Ile Ala Asn Asn Asn Ala Gly 
                85                  90                  95      


Asn Pro Leu Val Gln Gln Gly Gly Gln Pro Leu Ile Leu Thr Gln Asn 
            100                 105                 110         


Pro Ala Pro Gly Leu Gly Thr Met Val Thr Gln Pro Val Leu Arg Pro 
        115                 120                 125             


Val Gln Val Met Gln Asn Ala Asn His Val Thr Ser Ser Pro Val Ala 
    130                 135                 140                 


Ser Gln Pro Ile Phe Ile Thr Thr Gln Gly Phe Pro Val Arg Asn Val 
145                 150                 155                 160 


Arg Pro Val Gln Asn Ala Met Asn Gln Val Gly Ile Val Leu Asn Val 
                165                 170                 175     


Gln Gln Gly Gln Thr Val Arg Pro Ile Thr Leu Val Pro Ala Pro Gly 
            180                 185                 190         


Thr Gln Phe Val Lys Pro Thr Val Gly Val Pro Gln Val Phe Ser Gln 
        195                 200                 205             


Met Thr Pro Val Arg Pro Gly Ser Thr Met Pro Val Arg Pro Thr Thr 
    210                 215                 220                 


Asn Thr Phe Thr Thr Val Ile Pro Ala Thr Leu Thr Ile Arg Ser Thr 
225                 230                 235                 240 


Val Pro Gln Ser Gln Ser Gln Gln Thr Lys Ser Thr Pro Ser Thr Ser 
                245                 250                 255     


Thr Thr Pro Thr Ala Thr Gln Pro Thr Ser Leu Gly Gln Leu Ala Val 
            260                 265                 270         


Gln Ser Pro Gly Gln Ser Asn Gln Thr Thr Asn Pro Lys Leu Ala Pro 
        275                 280                 285             


Ser Phe Pro Ser Pro Pro Ala Val Ser Ile Ala Ser Phe Val Thr Val 
    290                 295                 300                 


Lys Arg Pro Gly Val Thr Gly Glu Asn Ser Asn Glu Val Ala Lys Leu 
305                 310                 315                 320 


Val Asn Thr Leu Asn Thr Ile Pro Ser Leu Gly Gln Ser Pro Gly Pro 
                325                 330                 335     


Val Val Val Ser Asn Asn Ser Ser Ala His Gly Ser Gln Arg Thr Ser 
            340                 345                 350         


Gly Pro Glu Ser Ser Met Lys Val Thr Ser Ser Ile Pro Val Phe Asp 
        355                 360                 365             


Leu Gln Asp Gly Gly Arg Lys Ile Cys Pro Arg Cys Asn Ala Gln Phe 
    370                 375                 380                 


Arg Val Thr Glu Ala Leu Arg Gly His Met Cys Tyr Cys Cys Pro Glu 
385                 390                 395                 400 


Met Val Glu Tyr Gln Lys Lys Gly Lys Ser Leu Asp Ser Glu Pro Ser 
                405                 410                 415     


Val Pro Ser Ala Ala Lys Pro Pro Ser Pro Glu Lys Thr Ala Pro Val 
            420                 425                 430         


Ala Ser Thr Pro Ser Ser Thr Pro Ile Pro Ala Leu Ser Pro Pro Thr 
        435                 440                 445             


Lys Val Pro Glu Pro Asn Glu Asn Val Gly Asp Ala Val Gln Thr Lys 
    450                 455                 460                 


Leu Ile Met Leu Val Asp Asp Phe Tyr Tyr Gly Arg Asp Gly Gly Lys 
465                 470                 475                 480 


Val Ala Gln Leu Thr Asn Phe Pro Lys Val Ala Thr Ser Phe Arg Cys 
                485                 490                 495     


Pro His Cys Thr Lys Arg Leu Lys Asn Asn Ile Arg Phe Met Asn His 
            500                 505                 510         


Met Lys His His Val Glu Leu Asp Gln Gln Asn Gly Glu Val Asp Gly 
        515                 520                 525             


His Thr Ile Cys Gln His Cys Tyr Arg Gln Phe Ser Thr Pro Phe Gln 
    530                 535                 540                 


Leu Gln Cys His Leu Glu Asn Val His Ser Pro Tyr Glu Ser Thr Thr 
545                 550                 555                 560 


Lys Cys Lys Ile Cys Glu Trp Ala Phe Glu Ser Glu Pro Leu Phe Leu 
                565                 570                 575     


Gln His Met Lys Asp Thr His Lys Pro Gly Glu Met Pro Tyr Val Cys 
            580                 585                 590         


Gln Val Cys Gln Tyr Arg Ser Ser Leu Tyr Ser Glu Val Asp Val His 
        595                 600                 605             


Phe Arg Met Ile His Glu Asp Thr Arg His Leu Leu Cys Pro Tyr Cys 
    610                 615                 620                 


Leu Lys Val Phe Lys Asn Gly Asn Ala Phe Gln Gln His Tyr Met Arg 
625                 630                 635                 640 


His Gln Lys Arg Asn Val Tyr His Cys Asn Lys Cys Arg Leu Gln Phe 
                645                 650                 655     


Leu Phe Ala Lys Asp Lys Ile Glu His Lys Leu Gln His His Lys Thr 
            660                 665                 670         


Phe Arg Lys Pro Lys Gln Leu Glu Gly Leu Lys Pro Gly Thr Lys Val 
        675                 680                 685             


Thr Ile Arg Ala Ser Arg Gly Gln Pro Arg Thr Val Pro Val Ser Ser 
    690                 695                 700                 


Asn Asp Thr Pro Pro Ser Ala Leu Gln Glu Ala Ala Pro Leu Thr Ser 
705                 710                 715                 720 


Ser Met Asp Pro Leu Pro Val Phe Leu Tyr Pro Pro Val Gln Arg Ser 
                725                 730                 735     


Ile Gln Lys Arg Ala Val Arg Lys Met Ser Val Met Gly Arg Gln Thr 
            740                 745                 750         


Cys Leu Glu Cys Ser Phe Glu Ile Pro Asp Phe Pro Asn His Phe Pro 
        755                 760                 765             


Thr Tyr Val His Cys Ser Leu Cys Arg Tyr Ser Thr Cys Cys Ser Arg 
    770                 775                 780                 


Ala Tyr Ala Asn His Met Ile Asn Asn His Val Pro Arg Lys Ser Pro 
785                 790                 795                 800 


Lys Tyr Leu Ala Leu Phe Lys Asn Ser Val Ser Gly Ile Lys Leu Ala 
                805                 810                 815     


Cys Thr Ser Cys Thr Phe Val Thr Ser Val Gly Asp Ala Met Ala Lys 
            820                 825                 830         


His Leu Val Phe Asn Pro Ser His Arg Ser Ser Ser Ile Leu Pro Arg 
        835                 840                 845             


Gly Leu Thr Trp Ile Ala His Ser Arg His Gly Gln Thr Arg Asp Arg 
    850                 855                 860                 


Val His Asp Arg Asn Val Lys Asn Met Tyr Pro Pro Pro Ser Phe Pro 
865                 870                 875                 880 


Thr Asn Lys Ala Ala Thr Val Lys Ser Ala Gly Ala Thr Pro Ala Glu 
                885                 890                 895     


Pro Glu Glu Leu Leu Thr Pro Leu Ala Pro Ala Leu Pro Ser Pro Ala 
            900                 905                 910         


Ser Thr Ala Thr Pro Pro Pro Thr Pro Thr His Pro Gln Ala Leu Ala 
        915                 920                 925             


Leu Pro Pro Leu Ala Thr Glu Gly Ala Glu Cys Leu Asn Val Asp Asp 
    930                 935                 940                 


Gln Asp Glu Gly Ser Pro Val Thr Gln Glu Pro Glu Leu Ala Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser Gly Gly Val Gly Lys Lys Glu Gln Leu Ser Val Lys 
                965                 970                 975     


Lys Leu Arg Val Val Leu Phe Ala Leu Cys Cys Asn Thr Glu Gln Ala 
            980                 985                 990         


Ala Glu His Phe Arg Asn Pro Gln  Arg Arg Ile Arg Arg  Trp Leu Arg 
        995                 1000                 1005             


Arg Phe  Gln Ala Ser Gln Gly  Glu Asn Leu Glu Gly  Lys Tyr Leu 
    1010                 1015                 1020             


Ser Phe  Glu Ala Glu Glu Lys  Leu Ala Glu Trp Val  Leu Thr Gln 
    1025                 1030                 1035             


Arg Glu  Gln Gln Leu Pro Val  Asn Glu Glu Thr Leu  Phe Gln Lys 
    1040                 1045                 1050             


Ala Thr  Lys Ile Gly Arg Ser  Leu Glu Gly Gly Phe  Lys Ile Ser 
    1055                 1060                 1065             


Tyr Glu  Trp Ala Val Arg Phe  Met Leu Arg His His  Leu Thr Pro 
    1070                 1075                 1080             


His Ala  Arg Arg Ala Val Ala  His Thr Leu Pro Lys  Asp Val Ala 
    1085                 1090                 1095             


Glu Asn  Ala Gly Leu Phe Ile  Asp Phe Val Gln Arg  Gln Ile His 
    1100                 1105                 1110             


Asn Gln  Asp Leu Pro Leu Ser  Met Ile Val Ala Ile  Asp Glu Ile 
    1115                 1120                 1125             


Ser Leu  Phe Leu Asp Thr Glu  Val Leu Ser Ser Asp  Asp Arg Lys 
    1130                 1135                 1140             


Glu Asn  Ala Leu Gln Thr Val  Gly Thr Gly Glu Pro  Trp Cys Asp 
    1145                 1150                 1155             


Val Val  Leu Ala Ile Leu Ala  Asp Gly Thr Val Leu  Pro Thr Leu 
    1160                 1165                 1170             


Val Phe  Tyr Arg Gly Gln Met  Asp Gln Pro Ala Asn  Met Pro Asp 
    1175                 1180                 1185             


Ser Ile  Leu Leu Glu Ala Lys  Glu Ser Gly Tyr Ser  Asp Asp Glu 
    1190                 1195                 1200             


Ile Met  Glu Leu Trp Ser Thr  Arg Val Trp Gln Lys  His Thr Ala 
    1205                 1210                 1215             


Cys Gln  Arg Ser Lys Gly Met  Leu Val Met Asp Cys  His Arg Thr 
    1220                 1225                 1230             


His Leu  Ser Glu Glu Val Leu  Ala Met Leu Ser Ala  Ser Ser Thr 
    1235                 1240                 1245             


Leu Pro  Ala Val Val Pro Ala  Gly Cys Ser Ser Lys  Ile Gln Pro 
    1250                 1255                 1260             


Leu Asp  Val Cys Ile Lys Arg  Thr Val Lys Asn Phe  Leu His Lys 
    1265                 1270                 1275             


Lys Trp  Lys Glu Gln Ala Arg  Glu Met Ala Asp Thr  Ala Cys Asp 
    1280                 1285                 1290             


Ser Asp  Val Leu Leu Gln Leu  Val Leu Val Trp Leu  Gly Glu Val 
    1295                 1300                 1305             


Leu Gly  Val Ile Gly Asp Cys  Pro Glu Leu Val Gln  Arg Ser Phe 
    1310                 1315                 1320             


Leu Val  Ala Ser Val Leu Pro  Gly Pro Asp Gly Asn  Ile Asn Ser 
    1325                 1330                 1335             


Pro Thr  Arg Asn Ala Asp Met  Gln Glu Glu Leu Ile  Ala Ser Leu 
    1340                 1345                 1350             


Glu Glu  Gln Leu Lys Leu Ser  Gly Glu His Ser Glu  Ser Ser Thr 
    1355                 1360                 1365             


Pro Arg  Pro Arg Ser Ser Pro  Glu Glu Thr Ile Glu  Pro Glu Ser 
    1370                 1375                 1380             


Leu His  Gln Leu Phe Glu Gly  Glu Ser Glu Thr Glu  Ser Phe Tyr 
    1385                 1390                 1395             


Gly Phe  Glu Glu Ala Asp Leu  Asp Leu Met Glu Ile  
    1400                 1405                 1410 


<210> 243
<211> 1603
<212> PRT
<213> Homo sapiens

<400> 243
Met Arg Val Lys Pro Gln Gly Leu Val Val Thr Ser Ser Ala Val Cys 
1               5                   10                  15      


Ser Ser Pro Asp Tyr Leu Arg Glu Pro Lys Tyr Tyr Pro Gly Gly Pro 
            20                  25                  30          


Pro Thr Pro Arg Pro Leu Leu Pro Thr Arg Pro Pro Ala Ser Pro Pro 
        35                  40                  45              


Asp Lys Ala Phe Ser Thr His Ala Phe Ser Glu Asn Pro Arg Pro Pro 
    50                  55                  60                  


Pro Arg Arg Asp Pro Ser Thr Arg Arg Pro Pro Val Leu Ala Lys Gly 
65                  70                  75                  80  


Asp Asp Pro Leu Pro Pro Arg Ala Ala Arg Pro Val Ser Gln Ala Arg 
                85                  90                  95      


Cys Pro Thr Pro Val Gly Asp Gly Ser Ser Ser Arg Arg Cys Trp Asp 
            100                 105                 110         


Asn Gly Arg Val Asn Leu Arg Pro Val Val Gln Leu Ile Asp Ile Met 
        115                 120                 125             


Lys Asp Leu Thr Arg Leu Ser Gln Asp Leu Gln His Ser Gly Val His 
    130                 135                 140                 


Leu Asp Cys Gly Gly Leu Arg Leu Ser Arg Pro Pro Ala Pro Pro Pro 
145                 150                 155                 160 


Gly Asp Leu Gln Tyr Ser Phe Phe Ser Ser Pro Ser Leu Ala Asn Ser 
                165                 170                 175     


Ile Arg Ser Pro Glu Glu Arg Ala Thr Pro His Ala Lys Ser Glu Arg 
            180                 185                 190         


Pro Ser His Pro Leu Tyr Glu Pro Glu Pro Glu Pro Arg Asp Ser Pro 
        195                 200                 205             


Gln Pro Gly Gln Gly His Ser Pro Gly Ala Thr Ala Ala Ala Thr Gly 
    210                 215                 220                 


Leu Pro Pro Glu Pro Glu Pro Asp Ser Thr Asp Tyr Ser Glu Leu Ala 
225                 230                 235                 240 


Asp Ala Asp Ile Leu Ser Glu Leu Ala Ser Leu Thr Cys Pro Glu Ala 
                245                 250                 255     


Gln Leu Leu Glu Ala Gln Ala Leu Glu Pro Pro Ser Pro Glu Pro Glu 
            260                 265                 270         


Pro Gln Leu Leu Asp Pro Gln Pro Arg Phe Leu Asp Pro Gln Ala Leu 
        275                 280                 285             


Glu Pro Leu Gly Glu Ala Leu Glu Leu Pro Pro Leu Gln Pro Leu Ala 
    290                 295                 300                 


Asp Pro Leu Gly Leu Pro Gly Leu Ala Leu Gln Ala Leu Asp Thr Leu 
305                 310                 315                 320 


Pro Asp Ser Leu Glu Ser Gln Leu Leu Asp Pro Gln Ala Leu Asp Pro 
                325                 330                 335     


Leu Pro Lys Leu Leu Asp Val Pro Gly Arg Arg Leu Glu Pro Gln Gln 
            340                 345                 350         


Pro Leu Gly His Cys Pro Leu Ala Glu Pro Leu Arg Leu Asp Leu Cys 
        355                 360                 365             


Ser Pro His Gly Pro Pro Gly Pro Glu Gly His Pro Lys Tyr Ala Leu 
    370                 375                 380                 


Arg Arg Thr Asp Arg Pro Lys Ile Leu Cys Arg Arg Arg Lys Ala Gly 
385                 390                 395                 400 


Arg Gly Arg Lys Ala Asp Ala Gly Pro Glu Gly Arg Leu Leu Pro Leu 
                405                 410                 415     


Pro Met Pro Thr Gly Leu Val Ala Ala Leu Ala Glu Pro Pro Pro Pro 
            420                 425                 430         


Pro Pro Pro Pro Pro Pro Ala Leu Pro Gly Pro Gly Pro Val Ser Val 
        435                 440                 445             


Pro Glu Leu Lys Pro Glu Ser Ser Gln Thr Pro Val Val Ser Thr Arg 
    450                 455                 460                 


Lys Gly Lys Cys Arg Gly Val Arg Arg Met Val Val Lys Met Ala Lys 
465                 470                 475                 480 


Ile Pro Val Ser Leu Gly Arg Arg Asn Lys Thr Thr Tyr Lys Val Ser 
                485                 490                 495     


Ser Leu Ser Ser Ser Leu Ser Val Glu Gly Lys Glu Leu Gly Leu Arg 
            500                 505                 510         


Val Ser Ala Glu Pro Thr Pro Leu Leu Lys Met Lys Asn Asn Gly Arg 
        515                 520                 525             


Asn Val Val Val Val Phe Pro Pro Gly Glu Met Pro Ile Ile Leu Lys 
    530                 535                 540                 


Arg Lys Arg Gly Arg Pro Pro Lys Asn Leu Leu Leu Gly Pro Gly Lys 
545                 550                 555                 560 


Pro Lys Glu Pro Ala Val Val Ala Ala Glu Ala Ala Thr Val Ala Ala 
                565                 570                 575     


Ala Thr Met Ala Met Pro Glu Val Lys Lys Arg Arg Arg Arg Lys Gln 
            580                 585                 590         


Lys Leu Ala Ser Pro Gln Pro Ser Tyr Ala Ala Asp Ala Asn Asp Ser 
        595                 600                 605             


Lys Ala Glu Tyr Ser Asp Val Leu Ala Lys Leu Ala Phe Leu Asn Arg 
    610                 615                 620                 


Gln Ser Gln Cys Ala Gly Arg Cys Ser Pro Pro Arg Cys Trp Thr Pro 
625                 630                 635                 640 


Ser Glu Pro Glu Ser Val His Gln Ala Pro Asp Thr Gln Ser Ile Ser 
                645                 650                 655     


His Phe Leu His Arg Val Gln Gly Phe Arg Arg Arg Gly Gly Lys Ala 
            660                 665                 670         


Gly Gly Phe Gly Gly Arg Gly Gly Gly His Ala Ala Lys Ser Ala Arg 
        675                 680                 685             


Cys Ser Phe Ser Asp Phe Phe Glu Gly Ile Gly Lys Lys Lys Lys Val 
    690                 695                 700                 


Val Ala Val Ala Ala Ala Gly Val Gly Gly Pro Gly Leu Thr Glu Leu 
705                 710                 715                 720 


Gly His Pro Arg Lys Arg Gly Arg Gly Glu Val Asp Ala Val Thr Gly 
                725                 730                 735     


Lys Pro Lys Arg Lys Arg Arg Ser Arg Lys Asn Gly Thr Leu Phe Pro 
            740                 745                 750         


Glu Gln Val Pro Ser Gly Pro Gly Phe Gly Glu Ala Gly Ala Glu Trp 
        755                 760                 765             


Ala Gly Asp Lys Gly Gly Gly Trp Ala Pro His His Gly His Pro Gly 
    770                 775                 780                 


Gly Gln Ala Gly Arg Asn Cys Gly Phe Gln Gly Thr Glu Ala Arg Ala 
785                 790                 795                 800 


Phe Ala Ser Thr Gly Leu Glu Ser Gly Ala Ser Gly Arg Gly Ser Tyr 
                805                 810                 815     


Tyr Ser Thr Gly Ala Pro Ser Gly Gln Thr Glu Leu Ser Gln Glu Arg 
            820                 825                 830         


Gln Asn Leu Phe Thr Gly Tyr Phe Arg Ser Leu Leu Asp Ser Asp Asp 
        835                 840                 845             


Ser Ser Asp Leu Leu Asp Phe Ala Leu Ser Ala Ser Arg Pro Glu Ser 
    850                 855                 860                 


Arg Lys Ala Ser Gly Thr Tyr Ala Gly Pro Pro Thr Ser Ala Leu Pro 
865                 870                 875                 880 


Ala Gln Arg Gly Leu Ala Thr Phe Pro Ser Arg Gly Ala Lys Ala Ser 
                885                 890                 895     


Pro Val Ala Val Gly Ser Ser Gly Ala Gly Ala Asp Pro Ser Phe Gln 
            900                 905                 910         


Pro Val Leu Ser Ala Arg Gln Thr Phe Pro Pro Gly Arg Ala Ala Ser 
        915                 920                 925             


Tyr Gly Leu Thr Pro Ala Ala Ser Asp Cys Arg Ala Ala Glu Thr Phe 
    930                 935                 940                 


Pro Lys Leu Val Pro Pro Pro Ser Ala Met Ala Arg Ser Pro Thr Thr 
945                 950                 955                 960 


His Pro Pro Ala Asn Thr Tyr Leu Pro Gln Tyr Gly Gly Tyr Gly Ala 
                965                 970                 975     


Gly Gln Ser Val Phe Ala Pro Thr Lys Pro Phe Thr Gly Gln Asp Cys 
            980                 985                 990         


Ala Asn Ser Lys Asp Cys Ser Phe  Ala Tyr Gly Ser Gly  Asn Ser Leu 
        995                 1000                 1005             


Pro Ala  Ser Pro Ser Ser Ala  His Ser Ala Gly Tyr  Ala Pro Pro 
    1010                 1015                 1020             


Pro Thr  Gly Gly Pro Cys Leu  Pro Pro Ser Lys Ala  Ser Phe Phe 
    1025                 1030                 1035             


Ser Ser  Ser Glu Gly Ala Pro  Phe Ser Gly Ser Ala  Pro Thr Pro 
    1040                 1045                 1050             


Leu Arg  Cys Asp Ser Arg Ala  Ser Thr Val Ser Pro  Gly Gly Tyr 
    1055                 1060                 1065             


Met Val  Pro Lys Gly Thr Thr  Ala Ser Ala Thr Ser  Ala Ala Ser 
    1070                 1075                 1080             


Ala Ala  Ser Ser Ser Ser Ser  Ser Phe Gln Pro Ser  Pro Glu Asn 
    1085                 1090                 1095             


Cys Arg  Gln Phe Ala Gly Ala  Ser Gln Trp Pro Phe  Arg Gln Gly 
    1100                 1105                 1110             


Tyr Gly  Gly Leu Asp Trp Ala  Ser Glu Ala Phe Ser  Gln Leu Tyr 
    1115                 1120                 1125             


Asn Pro  Ser Phe Asp Cys His  Val Ser Glu Pro Asn  Val Ile Leu 
    1130                 1135                 1140             


Asp Ile  Ser Asn Tyr Thr Pro  Gln Lys Val Lys Gln  Gln Thr Ala 
    1145                 1150                 1155             


Val Ser  Glu Thr Phe Ser Glu  Ser Ser Ser Asp Ser  Thr Gln Phe 
    1160                 1165                 1170             


Asn Gln  Pro Val Gly Gly Gly  Gly Phe Arg Arg Ala  Asn Ser Glu 
    1175                 1180                 1185             


Ala Ser  Ser Ser Glu Gly Gln  Ser Ser Leu Ser Ser  Leu Glu Lys 
    1190                 1195                 1200             


Leu Met  Met Asp Trp Asn Glu  Ala Ser Ser Ala Pro  Gly Tyr Asn 
    1205                 1210                 1215             


Trp Asn  Gln Ser Val Leu Phe  Gln Ser Ser Ser Lys  Pro Gly Arg 
    1220                 1225                 1230             


Gly Arg  Arg Lys Lys Val Asp  Leu Phe Glu Ala Ser  His Leu Gly 
    1235                 1240                 1245             


Phe Pro  Thr Ser Ala Ser Ala  Ala Ala Ser Gly Tyr  Pro Ser Lys 
    1250                 1255                 1260             


Arg Ser  Thr Gly Pro Arg Gln  Pro Arg Gly Gly Arg  Gly Gly Gly 
    1265                 1270                 1275             


Ala Cys  Ser Ala Lys Lys Glu  Arg Gly Gly Ala Ala  Ala Lys Ala 
    1280                 1285                 1290             


Lys Phe  Ile Pro Lys Pro Gln  Pro Val Asn Pro Leu  Phe Gln Asp 
    1295                 1300                 1305             


Ser Pro  Asp Leu Gly Leu Asp  Tyr Tyr Ser Gly Asp  Ser Ser Met 
    1310                 1315                 1320             


Ser Pro  Leu Pro Ser Gln Ser  Arg Ala Phe Gly Val  Gly Glu Arg 
    1325                 1330                 1335             


Asp Pro  Cys Asp Phe Ile Gly  Pro Tyr Ser Met Asn  Pro Ser Thr 
    1340                 1345                 1350             


Pro Ser  Asp Gly Thr Phe Gly  Gln Gly Phe His Cys  Asp Ser Pro 
    1355                 1360                 1365             


Ser Leu  Gly Ala Pro Glu Leu  Asp Gly Lys His Phe  Pro Pro Leu 
    1370                 1375                 1380             


Ala His  Pro Pro Thr Val Phe  Asp Ala Gly Leu Gln  Lys Ala Tyr 
    1385                 1390                 1395             


Ser Pro  Thr Cys Ser Pro Thr  Leu Gly Phe Lys Glu  Glu Leu Arg 
    1400                 1405                 1410             


Pro Pro  Pro Thr Lys Leu Ala  Ala Cys Glu Pro Leu  Lys His Gly 
    1415                 1420                 1425             


Leu Gln  Gly Ala Ser Leu Gly  His Ala Ala Ala Ala  Gln Ala His 
    1430                 1435                 1440             


Leu Ser  Cys Arg Asp Leu Pro  Leu Gly Gln Pro His  Tyr Asp Ser 
    1445                 1450                 1455             


Pro Ser  Cys Lys Gly Thr Ala  Tyr Trp Tyr Pro Pro  Gly Ser Ala 
    1460                 1465                 1470             


Ala Arg  Ser Pro Pro Tyr Glu  Gly Lys Val Gly Thr  Gly Leu Leu 
    1475                 1480                 1485             


Ala Asp  Phe Leu Gly Arg Thr  Glu Ala Ala Cys Leu  Ser Ala Pro 
    1490                 1495                 1500             


His Leu  Ala Ser Pro Pro Ala  Thr Pro Lys Ala Asp  Lys Glu Pro 
    1505                 1510                 1515             


Leu Glu  Met Ala Arg Pro Pro  Gly Pro Pro Arg Gly  Pro Ala Ala 
    1520                 1525                 1530             


Ala Ala  Ala Gly Tyr Gly Cys  Pro Leu Leu Ser Asp  Leu Thr Leu 
    1535                 1540                 1545             


Ser Pro  Val Pro Arg Asp Ser  Leu Leu Pro Leu Gln  Asp Thr Ala 
    1550                 1555                 1560             


Tyr Arg  Tyr Pro Gly Phe Met  Pro Gln Ala His Pro  Gly Leu Gly 
    1565                 1570                 1575             


Gly Gly  Pro Lys Ser Gly Phe  Leu Gly Pro Met Ala  Glu Pro His 
    1580                 1585                 1590             


Pro Glu  Asp Thr Phe Thr Val  Thr Ser Leu 
    1595                 1600             


<210> 244
<211> 2414
<212> PRT
<213> Homo sapiens

<400> 244
Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu 
        675                 680                 685             


Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro 
    690                 695                 700                 


Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met 
705                 710                 715                 720 


Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His 
                725                 730                 735     


Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly 
            740                 745                 750         


Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr 
        755                 760                 765             


Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro 
    770                 775                 780                 


Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser 
785                 790                 795                 800 


Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His 
                805                 810                 815     


Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro 
            820                 825                 830         


Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser 
        835                 840                 845             


Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro 
865                 870                 875                 880 


Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln 
                885                 890                 895     


Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln 
            900                 905                 910         


Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr 
        915                 920                 925             


Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala 
    930                 935                 940                 


Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr 
945                 950                 955                 960 


Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val 
                965                 970                 975     


Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr 
            980                 985                 990         


Gln Pro Glu Asp Ile Ser Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu 
        995                 1000                 1005             


Ser Thr  Glu Thr Glu Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile 
    1010                 1015                 1020             


Lys Glu  Glu Glu Asp Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser 
    1025                 1030                 1035             


Pro Ala  Pro Gly Gln Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu 
    1040                 1045                 1050             


Leu Arg  Gln Ala Leu Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln 
    1055                 1060                 1065             


Asp Pro  Glu Ser Leu Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu 
    1070                 1075                 1080             


Leu Gly  Ile Pro Asp Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp 
    1085                 1090                 1095             


Leu Ser  Thr Ile Lys Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu 
    1100                 1105                 1110             


Pro Trp  Gln Tyr Val Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala 
    1115                 1120                 1125             


Trp Leu  Tyr Asn Arg Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser 
    1130                 1135                 1140             


Lys Leu  Ser Glu Val Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln 
    1145                 1150                 1155             


Ser Leu  Gly Tyr Cys Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln 
    1160                 1165                 1170             


Thr Leu  Cys Cys Tyr Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp 
    1175                 1180                 1185             


Ala Thr  Tyr Tyr Ser Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys 
    1190                 1195                 1200             


Cys Phe  Asn Glu Ile Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp 
    1205                 1210                 1215             


Pro Ser  Gln Pro Gln Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys 
    1220                 1225                 1230             


Arg Lys  Asn Asp Thr Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr 
    1235                 1240                 1245             


Glu Cys  Gly Arg Lys Met His  Gln Ile Cys Val Leu  His His Glu 
    1250                 1255                 1260             


Ile Ile  Trp Pro Ala Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys 
    1265                 1270                 1275             


Ser Ala  Arg Thr Arg Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu 
    1280                 1285                 1290             


Pro Ser  Thr Arg Leu Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp 
    1295                 1300                 1305             


Phe Leu  Arg Arg Gln Asn His  Pro Glu Ser Gly Glu  Val Thr Val 
    1310                 1315                 1320             


Arg Val  Val His Ala Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly 
    1325                 1330                 1335             


Met Lys  Ala Arg Phe Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe 
    1340                 1345                 1350             


Pro Tyr  Arg Thr Lys Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly 
    1355                 1360                 1365             


Val Asp  Leu Cys Phe Phe Gly  Met His Val Gln Glu  Tyr Gly Ser 
    1370                 1375                 1380             


Asp Cys  Pro Pro Pro Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu 
    1385                 1390                 1395             


Asp Ser  Val His Phe Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val 
    1400                 1405                 1410             


Tyr His  Glu Ile Leu Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu 
    1415                 1420                 1425             


Gly Tyr  Thr Thr Gly His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly 
    1430                 1435                 1440             


Asp Asp  Tyr Ile Phe His Cys  His Pro Pro Asp Gln  Lys Ile Pro 
    1445                 1450                 1455             


Lys Pro  Lys Arg Leu Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys 
    1460                 1465                 1470             


Ala Val  Ser Glu Arg Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys 
    1475                 1480                 1485             


Gln Ala  Thr Glu Asp Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr 
    1490                 1495                 1500             


Phe Glu  Gly Asp Phe Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys 
    1505                 1510                 1515             


Glu Leu  Glu Gln Glu Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr 
    1520                 1525                 1530             


Ser Asn  Glu Ser Thr Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala 
    1535                 1540                 1545             


Lys Lys  Lys Asn Asn Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu 
    1550                 1555                 1560             


Ser Arg  Gly Asn Lys Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn 
    1565                 1570                 1575             


Asp Leu  Ser Gln Lys Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu 
    1580                 1585                 1590             


Val Phe  Phe Val Ile Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser 
    1595                 1600                 1605             


Leu Pro  Pro Ile Val Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu 
    1610                 1615                 1620             


Met Asp  Gly Arg Asp Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His 
    1625                 1630                 1635             


Leu Glu  Phe Ser Ser Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys 
    1640                 1645                 1650             


Met Leu  Val Glu Leu His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr 
    1655                 1660                 1665             


Thr Cys  Asn Glu Cys Lys His  His Val Glu Thr Arg  Trp His Cys 
    1670                 1675                 1680             


Thr Val  Cys Glu Asp Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr 
    1685                 1690                 1695             


Lys Asn  His Asp His Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp 
    1700                 1705                 1710             


Asp Glu  Ser Asn Asn Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly 
    1715                 1720                 1725             


Asp Ser  Arg Arg Leu Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val 
    1730                 1735                 1740             


His Ala  Cys Gln Cys Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys 
    1745                 1750                 1755             


Gln Lys  Met Lys Arg Val Val  Gln His Thr Lys Gly  Cys Lys Arg 
    1760                 1765                 1770             


Lys Thr  Asn Gly Gly Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu 
    1775                 1780                 1785             


Cys Cys  Tyr His Ala Lys His  Cys Gln Glu Asn Lys  Cys Pro Val 
    1790                 1795                 1800             


Pro Phe  Cys Leu Asn Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu 
    1805                 1810                 1815             


Gln His  Arg Leu Gln Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala 
    1820                 1825                 1830             


Ser Met  Gln Arg Thr Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro 
    1835                 1840                 1845             


Ser Pro  Thr Pro Ala Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro 
    1850                 1855                 1860             


Thr Thr  Pro Gln Thr Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr 
    1865                 1870                 1875             


Pro Pro  Asn Ser Met Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala 
    1880                 1885                 1890             


Gly Pro  Val Ser Gln Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro 
    1895                 1900                 1905             


Thr Pro  Pro Gln Thr Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro 
    1910                 1915                 1920             


Ala Ala  Val Glu Met Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr 
    1925                 1930                 1935             


Gln Arg  Gln Met Ala His Val  Gln Ile Phe Gln Arg  Pro Ile Gln 
    1940                 1945                 1950             


His Gln  Met Pro Pro Met Thr  Pro Met Ala Pro Met  Gly Met Asn 
    1955                 1960                 1965             


Pro Pro  Pro Met Thr Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly 
    1970                 1975                 1980             


Met Gly  Pro Thr Gly Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly 
    1985                 1990                 1995             


Gly Leu  Pro Gln Pro Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro 
    2000                 2005                 2010             


Ala Met  Met Ser Val Ala Gln  His Gly Gln Pro Leu  Asn Met Ala 
    2015                 2020                 2025             


Pro Gln  Pro Gly Leu Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro 
    2030                 2035                 2040             


Gly Thr  Val Ser Gln Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Arg Ser  Pro Ser Ser Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile 
    2060                 2065                 2070             


Leu His  Ala Asn Pro Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg 
    2075                 2080                 2085             


Ala Ala  Lys Tyr Ala Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln 
    2090                 2095                 2100             


Pro Gly  Met Pro Gln Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met 
    2105                 2110                 2115             


Pro Gly  Gln Gln Gly Val His  Ser Asn Pro Ala Met  Gln Asn Met 
    2120                 2125                 2130             


Asn Pro  Met Gln Ala Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln 
    2135                 2140                 2145             


Gln Pro  Gln Gln Gln Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro 
    2150                 2155                 2160             


Gln Ala  Gln Gln Met Asn Met  Asn His Asn Thr Met  Pro Ser Gln 
    2165                 2170                 2175             


Phe Arg  Asp Ile Leu Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln 
    2180                 2185                 2190             


Gln Gln  Gly Ala Gly Pro Gly  Ile Gly Pro Gly Met  Ala Asn His 
    2195                 2200                 2205             


Asn Gln  Phe Gln Gln Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln 
    2210                 2215                 2220             


Gln Gln  Arg Met Gln His His  Met Gln Gln Met Gln  Gln Gly Asn 
    2225                 2230                 2235             


Met Gly  Gln Ile Gly Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala 
    2240                 2245                 2250             


Gly Ala  Ser Leu Gln Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln 
    2255                 2260                 2265             


Met Gly  Ser Pro Val Gln Pro  Asn Pro Met Ser Pro  Gln Gln His 
    2270                 2275                 2280             


Met Leu  Pro Asn Gln Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln 
    2285                 2290                 2295             


Ile Pro  Asn Ser Leu Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val 
    2300                 2305                 2310             


Pro Ser  Pro Arg Pro Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser 
    2315                 2320                 2325             


Pro Arg  Met Gln Pro Gln Pro  Ser Pro His His Val  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ser  Ser Pro His Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro 
    2345                 2350                 2355             


Met Glu  Gln Gly His Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu 
    2360                 2365                 2370             


Ser Gln  Leu Ala Ser Asn Pro  Gly Met Ala Asn Leu  His Gly Ala 
    2375                 2380                 2385             


Ser Ala  Thr Asp Leu Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn 
    2390                 2395                 2400             


Ser Asn  Leu Ser Gln Ser Thr  Leu Asp Ile His 
    2405                 2410                 


<210> 245
<211> 1488
<212> PRT
<213> Homo sapiens

<400> 245
Met Glu Ala Gly Ser Gly Pro Pro Gly Gly Pro Gly Ser Glu Ser Pro 
1               5                   10                  15      


Asn Arg Ala Val Glu Tyr Leu Leu Glu Leu Asn Asn Ile Ile Glu Ser 
            20                  25                  30          


Gln Gln Gln Leu Leu Glu Thr Gln Arg Arg Arg Ile Glu Glu Leu Glu 
        35                  40                  45              


Gly Gln Leu Asp Gln Leu Thr Gln Glu Asn Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Ser Gln Leu His Arg Gly Glu Leu His Arg Asp Pro His Gly Ala Arg 
65                  70                  75                  80  


Asp Ser Pro Gly Arg Glu Ser Gln Tyr Gln Asn Leu Arg Glu Thr Gln 
                85                  90                  95      


Phe His His Arg Glu Leu Arg Glu Ser Gln Phe His Gln Ala Ala Arg 
            100                 105                 110         


Asp Val Gly Tyr Pro Asn Arg Glu Gly Ala Tyr Gln Asn Arg Glu Ala 
        115                 120                 125             


Val Tyr Arg Asp Lys Glu Arg Asp Ala Ser Tyr Pro Leu Gln Asp Thr 
    130                 135                 140                 


Thr Gly Tyr Thr Ala Arg Glu Arg Asp Val Ala Gln Cys His Leu His 
145                 150                 155                 160 


His Glu Asn Pro Ala Leu Gly Arg Glu Arg Gly Gly Arg Glu Ala Gly 
                165                 170                 175     


Pro Ala His Pro Gly Arg Glu Lys Glu Ala Gly Tyr Ser Ala Ala Val 
            180                 185                 190         


Gly Val Gly Pro Arg Pro Pro Arg Glu Arg Gly Gln Leu Ser Arg Gly 
        195                 200                 205             


Ala Ser Arg Ser Ser Ser Pro Gly Ala Gly Gly Gly His Ser Thr Ser 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ala Thr Thr Leu Gln Arg Lys Ser Asp Gly Glu 
225                 230                 235                 240 


Asn Ser Arg Thr Val Ser Val Glu Gly Asp Ala Pro Gly Ser Asp Leu 
                245                 250                 255     


Ser Thr Ala Val Asp Ser Pro Gly Ser Gln Pro Pro Tyr Arg Leu Ser 
            260                 265                 270         


Gln Leu Pro Pro Ser Ser Ser His Met Gly Gly Pro Pro Ala Gly Val 
        275                 280                 285             


Gly Leu Pro Trp Ala Gln Arg Ala Arg Leu Gln Pro Ala Ser Val Ala 
    290                 295                 300                 


Leu Arg Lys Gln Glu Glu Glu Glu Ile Lys Arg Ser Lys Ala Leu Ser 
305                 310                 315                 320 


Asp Ser Tyr Glu Leu Ser Thr Asp Leu Gln Asp Lys Lys Val Glu Met 
                325                 330                 335     


Leu Glu Arg Lys Tyr Gly Gly Ser Phe Leu Ser Arg Arg Ala Ala Arg 
            340                 345                 350         


Thr Ile Gln Thr Ala Phe Arg Gln Tyr Arg Met Asn Lys Asn Phe Glu 
        355                 360                 365             


Arg Leu Arg Ser Ser Ala Ser Glu Ser Arg Met Ser Arg Arg Ile Ile 
    370                 375                 380                 


Leu Ser Asn Met Arg Met Gln Phe Ser Phe Glu Glu Tyr Glu Lys Ala 
385                 390                 395                 400 


Gln Asn Pro Ala Tyr Phe Glu Gly Lys Pro Ala Ser Leu Asp Glu Gly 
                405                 410                 415     


Ala Met Ala Gly Ala Arg Ser His Arg Leu Glu Arg Gly Leu Pro Tyr 
            420                 425                 430         


Gly Gly Ser Cys Gly Gly Gly Ile Asp Gly Gly Gly Ser Ser Val Thr 
        435                 440                 445             


Thr Ser Gly Glu Phe Ser Asn Asp Ile Thr Glu Leu Glu Asp Ser Phe 
    450                 455                 460                 


Ser Lys Gln Val Lys Ser Leu Ala Glu Ser Ile Asp Glu Ala Leu Asn 
465                 470                 475                 480 


Cys His Pro Ser Gly Pro Met Ser Glu Glu Pro Gly Ser Ala Gln Leu 
                485                 490                 495     


Glu Lys Arg Glu Ser Lys Glu Gln Gln Glu Asp Ser Ser Ala Thr Ser 
            500                 505                 510         


Phe Ser Asp Leu Pro Leu Tyr Leu Asp Asp Thr Val Pro Gln Gln Ser 
        515                 520                 525             


Pro Glu Arg Leu Pro Ser Thr Glu Pro Pro Pro Gln Gly Arg Pro Glu 
    530                 535                 540                 


Phe Trp Ala Pro Ala Pro Leu Pro Pro Val Pro Pro Pro Val Pro Ser 
545                 550                 555                 560 


Gly Thr Arg Glu Asp Gly Ser Arg Glu Glu Gly Thr Arg Arg Gly Pro 
                565                 570                 575     


Gly Cys Leu Glu Cys Arg Asp Phe Arg Leu Arg Ala Ala His Leu Pro 
            580                 585                 590         


Leu Leu Thr Ile Glu Pro Pro Ser Asp Ser Ser Val Asp Leu Ser Asp 
        595                 600                 605             


Arg Ser Asp Arg Gly Ser Val His Arg Gln Leu Val Tyr Glu Ala Asp 
    610                 615                 620                 


Gly Cys Ser Pro His Gly Thr Leu Lys His Lys Gly Pro Pro Gly Arg 
625                 630                 635                 640 


Ala Pro Ile Pro His Arg His Tyr Pro Ala Pro Glu Gly Pro Ala Pro 
                645                 650                 655     


Ala Pro Pro Gly Pro Leu Pro Pro Ala Pro Asn Ser Gly Thr Gly Pro 
            660                 665                 670         


Ser Gly Val Ala Gly Gly Arg Arg Leu Gly Lys Cys Glu Ala Ala Gly 
        675                 680                 685             


Glu Asn Ser Asp Gly Gly Asp Asn Glu Ser Leu Glu Ser Ser Ser Asn 
    690                 695                 700                 


Ser Asn Glu Thr Ile Asn Cys Ser Ser Gly Ser Ser Ser Arg Asp Ser 
705                 710                 715                 720 


Leu Arg Glu Pro Pro Ala Thr Gly Leu Cys Lys Gln Thr Tyr Gln Arg 
                725                 730                 735     


Glu Thr Arg His Ser Trp Asp Ser Pro Ala Phe Asn Asn Asp Val Val 
            740                 745                 750         


Gln Arg Arg His Tyr Arg Ile Gly Leu Asn Leu Phe Asn Lys Lys Pro 
        755                 760                 765             


Glu Lys Gly Ile Gln Tyr Leu Ile Glu Arg Gly Phe Leu Ser Asp Thr 
    770                 775                 780                 


Pro Val Gly Val Ala His Phe Ile Leu Glu Arg Lys Gly Leu Ser Arg 
785                 790                 795                 800 


Gln Met Ile Gly Glu Phe Leu Gly Asn Arg Gln Lys Gln Phe Asn Arg 
                805                 810                 815     


Asp Val Leu Asp Cys Val Val Asp Glu Met Asp Phe Ser Ser Met Asp 
            820                 825                 830         


Leu Asp Asp Ala Leu Arg Lys Phe Gln Ser His Ile Arg Val Gln Gly 
        835                 840                 845             


Glu Ala Gln Lys Val Glu Arg Leu Ile Glu Ala Phe Ser Gln Arg Tyr 
    850                 855                 860                 


Cys Val Cys Asn Pro Ala Leu Val Arg Gln Phe Arg Asn Pro Asp Thr 
865                 870                 875                 880 


Ile Phe Ile Leu Ala Phe Ala Ile Ile Leu Leu Asn Thr Asp Met Tyr 
                885                 890                 895     


Ser Pro Ser Val Lys Ala Glu Arg Lys Met Lys Leu Asp Asp Phe Ile 
            900                 905                 910         


Lys Asn Leu Arg Gly Val Asp Asn Gly Glu Asp Ile Pro Arg Asp Leu 
        915                 920                 925             


Leu Val Gly Ile Tyr Gln Arg Ile Gln Gly Arg Glu Leu Arg Thr Asn 
    930                 935                 940                 


Asp Asp His Val Ser Gln Val Gln Ala Val Glu Arg Met Ile Val Gly 
945                 950                 955                 960 


Lys Lys Pro Val Leu Ser Leu Pro His Arg Arg Leu Val Cys Cys Cys 
                965                 970                 975     


Gln Leu Tyr Glu Val Pro Asp Pro Asn Arg Pro Gln Arg Leu Gly Leu 
            980                 985                 990         


His Gln Arg Glu Val Phe Leu Phe  Asn Asp Leu Leu Val  Val Thr Lys 
        995                 1000                 1005             


Ile Phe  Gln Lys Lys Lys Ile  Leu Val Thr Tyr Ser  Phe Arg Gln 
    1010                 1015                 1020             


Ser Phe  Pro Leu Val Glu Met  His Met Gln Leu Phe  Gln Asn Ser 
    1025                 1030                 1035             


Tyr Tyr  Gln Phe Gly Ile Lys  Leu Leu Ser Ala Val  Pro Gly Gly 
    1040                 1045                 1050             


Glu Arg  Lys Val Leu Ile Ile  Phe Asn Ala Pro Ser  Leu Gln Asp 
    1055                 1060                 1065             


Arg Leu  Arg Phe Thr Ser Asp  Leu Arg Glu Ser Ile  Ala Glu Val 
    1070                 1075                 1080             


Gln Glu  Met Glu Lys Tyr Arg  Val Glu Ser Glu Leu  Glu Lys Gln 
    1085                 1090                 1095             


Lys Gly  Met Met Arg Pro Asn  Ala Ser Gln Pro Gly  Gly Ala Lys 
    1100                 1105                 1110             


Asp Ser  Val Asn Gly Thr Met  Ala Arg Ser Ser Leu  Glu Asp Thr 
    1115                 1120                 1125             


Tyr Gly  Ala Gly Asp Gly Leu  Lys Arg Gly Ala Leu  Ser Ser Ser 
    1130                 1135                 1140             


Leu Arg  Asp Leu Ser Asp Ala  Gly Lys Arg Gly Arg  Arg Asn Ser 
    1145                 1150                 1155             


Val Gly  Ser Leu Asp Ser Thr  Ile Glu Gly Ser Val  Ile Ser Ser 
    1160                 1165                 1170             


Pro Arg  Pro His Gln Arg Met  Pro Pro Pro Pro Pro  Pro Pro Pro 
    1175                 1180                 1185             


Pro Glu  Glu Tyr Lys Ser Gln  Arg Pro Val Ser Asn  Ser Ser Ser 
    1190                 1195                 1200             


Phe Leu  Gly Ser Leu Phe Gly  Ser Lys Arg Gly Lys  Gly Pro Phe 
    1205                 1210                 1215             


Gln Met  Pro Pro Pro Pro Thr  Gly Gln Ala Ser Ala  Ser Ser Ser 
    1220                 1225                 1230             


Ser Ala  Ser Ser Thr His His  His His His His His  His His Gly 
    1235                 1240                 1245             


His Ser  His Gly Gly Leu Gly  Val Leu Pro Asp Gly  Gln Ser Lys 
    1250                 1255                 1260             


Leu Gln  Ala Leu His Ala Gln  Tyr Cys Gln Gly Pro  Gly Pro Ala 
    1265                 1270                 1275             


Pro Pro  Pro Tyr Leu Pro Pro  Gln Gln Pro Ser Leu  Pro Pro Pro 
    1280                 1285                 1290             


Pro Gln  Gln Pro Pro Pro Leu  Pro Gln Leu Gly Ser  Ile Pro Pro 
    1295                 1300                 1305             


Pro Pro  Ala Ser Ala Pro Pro  Val Gly Pro His Arg  His Phe His 
    1310                 1315                 1320             


Ala His  Gly Pro Val Pro Gly  Pro Gln His Tyr Thr  Leu Gly Arg 
    1325                 1330                 1335             


Pro Gly  Arg Ala Pro Arg Arg  Gly Ala Gly Gly His  Pro Gln Phe 
    1340                 1345                 1350             


Ala Pro  His Gly Arg His Pro  Leu His Gln Pro Thr  Ser Pro Leu 
    1355                 1360                 1365             


Pro Leu  Tyr Ser Pro Ala Pro  Gln His Pro Pro Ala  His Lys Gln 
    1370                 1375                 1380             


Gly Pro  Lys His Phe Ile Phe  Ser His His Pro Gln  Met Met Pro 
    1385                 1390                 1395             


Ala Ala  Gly Ala Ala Gly Gly  Pro Gly Ser Arg Pro  Pro Gly Gly 
    1400                 1405                 1410             


Ser Tyr  Ser His Pro His His  Pro Gln Ser Pro Leu  Ser Pro His 
    1415                 1420                 1425             


Ser Pro  Ile Pro Pro His Pro  Ser Tyr Pro Pro Leu  Pro Pro Pro 
    1430                 1435                 1440             


Ser Pro  His Thr Pro His Ser  Pro Leu Pro Pro Thr  Ser Pro His 
    1445                 1450                 1455             


Gly Pro  Leu His Ala Ser Gly  Pro Pro Gly Thr Ala  Asn Pro Pro 
    1460                 1465                 1470             


Ser Ala  Asn Pro Lys Ala Lys  Pro Ser Arg Ile Ser  Thr Val Val 
    1475                 1480                 1485             


<210> 246
<211> 1960
<212> PRT
<213> Homo sapiens

<400> 246
Met Gln Ser Phe Arg Glu Gln Ser Ser Tyr His Gly Asn Gln Gln Ser 
1               5                   10                  15      


Tyr Pro Gln Glu Val His Gly Ser Ser Arg Leu Glu Glu Phe Ser Pro 
            20                  25                  30          


Arg Gln Ala Gln Met Phe Gln Asn Phe Gly Gly Thr Gly Gly Ser Ser 
        35                  40                  45              


Gly Ser Ser Gly Ser Gly Ser Gly Gly Gly Arg Arg Gly Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Met Ala Ser Glu Thr Ser Gly His Gln Gly Tyr Gln 
65                  70                  75                  80  


Gly Phe Arg Lys Glu Ala Gly Asp Phe Tyr Tyr Met Ala Gly Asn Lys 
                85                  90                  95      


Asp Pro Val Thr Thr Gly Thr Pro Gln Pro Pro Gln Arg Arg Pro Ser 
            100                 105                 110         


Gly Pro Val Gln Ser Tyr Gly Pro Pro Gln Gly Ser Ser Phe Gly Asn 
        115                 120                 125             


Gln Tyr Gly Ser Glu Gly His Val Gly Gln Phe Gln Ala Gln His Ser 
    130                 135                 140                 


Gly Leu Gly Gly Val Ser His Tyr Gln Gln Asp Tyr Thr Gly Pro Phe 
145                 150                 155                 160 


Ser Pro Gly Ser Ala Gln Tyr Gln Gln Gln Ala Ser Ser Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Val Gln Gln Leu Arg Gln Gln Leu Tyr Gln Ser His Gln 
            180                 185                 190         


Pro Leu Pro Gln Ala Thr Gly Gln Pro Ala Ser Ser Ser Ser His Leu 
        195                 200                 205             


Gln Pro Met Gln Arg Pro Ser Thr Leu Pro Ser Ser Ala Ala Gly Tyr 
    210                 215                 220                 


Gln Leu Arg Val Gly Gln Phe Gly Gln His Tyr Gln Ser Ser Ala Ser 
225                 230                 235                 240 


Ser Ser Ser Ser Ser Ser Phe Pro Ser Pro Gln Arg Phe Ser Gln Ser 
                245                 250                 255     


Gly Gln Ser Tyr Asp Gly Ser Tyr Asn Val Asn Ala Gly Ser Gln Tyr 
            260                 265                 270         


Glu Gly His Asn Val Gly Ser Asn Ala Gln Ala Tyr Gly Thr Gln Ser 
        275                 280                 285             


Asn Tyr Ser Tyr Gln Pro Gln Ser Met Lys Asn Phe Glu Gln Ala Lys 
    290                 295                 300                 


Ile Pro Gln Gly Thr Gln Gln Gly Gln Gln Gln Gln Gln Pro Gln Gln 
305                 310                 315                 320 


Gln Gln His Pro Ser Gln His Val Met Gln Tyr Thr Asn Ala Ala Thr 
                325                 330                 335     


Lys Leu Pro Leu Gln Ser Gln Val Gly Gln Tyr Asn Gln Pro Glu Val 
            340                 345                 350         


Pro Val Arg Ser Pro Met Gln Phe His Gln Asn Phe Ser Pro Ile Ser 
        355                 360                 365             


Asn Pro Ser Pro Ala Ala Ser Val Val Gln Ser Pro Ser Cys Ser Ser 
    370                 375                 380                 


Thr Pro Ser Pro Leu Met Gln Thr Gly Glu Asn Leu Gln Cys Gly Gln 
385                 390                 395                 400 


Gly Ser Val Pro Met Gly Ser Arg Asn Arg Ile Leu Gln Leu Met Pro 
                405                 410                 415     


Gln Leu Ser Pro Thr Pro Ser Met Met Pro Ser Pro Asn Ser His Ala 
            420                 425                 430         


Ala Gly Phe Lys Gly Phe Gly Leu Glu Gly Val Pro Glu Lys Arg Leu 
        435                 440                 445             


Thr Asp Pro Gly Leu Ser Ser Leu Ser Ala Leu Ser Thr Gln Val Ala 
    450                 455                 460                 


Asn Leu Pro Asn Thr Val Gln His Met Leu Leu Ser Asp Ala Leu Thr 
465                 470                 475                 480 


Pro Gln Lys Lys Thr Ser Lys Arg Pro Ser Ser Ser Lys Lys Ala Asp 
                485                 490                 495     


Ser Cys Thr Asn Ser Glu Gly Ser Ser Gln Pro Glu Glu Gln Leu Lys 
            500                 505                 510         


Ser Pro Met Ala Glu Ser Leu Asp Gly Gly Cys Ser Ser Ser Ser Glu 
        515                 520                 525             


Asp Gln Gly Glu Arg Val Arg Gln Leu Ser Gly Gln Ser Thr Ser Ser 
    530                 535                 540                 


Asp Thr Thr Tyr Lys Gly Gly Ala Ser Glu Lys Ala Gly Ser Ser Pro 
545                 550                 555                 560 


Ala Gln Gly Ala Gln Asn Glu Pro Pro Arg Leu Asn Ala Ser Pro Ala 
                565                 570                 575     


Ala Arg Glu Glu Ala Thr Ser Pro Gly Ala Lys Asp Met Pro Leu Ser 
            580                 585                 590         


Ser Asp Gly Asn Pro Lys Val Asn Glu Lys Thr Val Gly Val Ile Val 
        595                 600                 605             


Ser Arg Glu Ala Met Thr Gly Arg Val Glu Lys Pro Gly Gly Gln Asp 
    610                 615                 620                 


Lys Gly Ser Gln Glu Asp Asp Pro Ala Ala Thr Gln Arg Pro Pro Ser 
625                 630                 635                 640 


Asn Gly Gly Ala Lys Glu Thr Ser His Ala Ser Leu Pro Gln Pro Glu 
                645                 650                 655     


Pro Pro Gly Gly Gly Gly Ser Lys Gly Asn Lys Asn Gly Asp Asn Asn 
            660                 665                 670         


Ser Asn His Asn Gly Glu Gly Asn Gly Gln Ser Gly His Ser Ala Ala 
        675                 680                 685             


Gly Pro Gly Phe Thr Ser Arg Thr Glu Pro Ser Lys Ser Pro Gly Ser 
    690                 695                 700                 


Leu Arg Tyr Ser Tyr Lys Asp Ser Phe Gly Ser Ala Val Pro Arg Asn 
705                 710                 715                 720 


Val Ser Gly Phe Pro Gln Tyr Pro Thr Gly Gln Glu Lys Gly Asp Phe 
                725                 730                 735     


Thr Gly His Gly Glu Arg Lys Gly Arg Asn Glu Lys Phe Pro Ser Leu 
            740                 745                 750         


Leu Gln Glu Val Leu Gln Gly Tyr His His His Pro Asp Arg Arg Tyr 
        755                 760                 765             


Ser Arg Ser Thr Gln Glu His Gln Gly Met Ala Gly Ser Leu Glu Gly 
    770                 775                 780                 


Thr Thr Arg Pro Asn Val Leu Val Ser Gln Thr Asn Glu Leu Ala Ser 
785                 790                 795                 800 


Arg Gly Leu Leu Asn Lys Ser Ile Gly Ser Leu Leu Glu Asn Pro His 
                805                 810                 815     


Trp Gly Pro Trp Glu Arg Lys Ser Ser Ser Thr Ala Pro Glu Met Lys 
            820                 825                 830         


Gln Ile Asn Leu Thr Asp Tyr Pro Ile Pro Arg Lys Phe Glu Ile Glu 
        835                 840                 845             


Pro Gln Ser Ser Ala His Glu Pro Gly Gly Ser Leu Ser Glu Arg Arg 
    850                 855                 860                 


Ser Val Ile Cys Asp Ile Ser Pro Leu Arg Gln Ile Val Arg Asp Pro 
865                 870                 875                 880 


Gly Ala His Ser Leu Gly His Met Ser Ala Asp Thr Arg Ile Gly Arg 
                885                 890                 895     


Asn Asp Arg Leu Asn Pro Thr Leu Ser Gln Ser Val Ile Leu Pro Gly 
            900                 905                 910         


Gly Leu Val Ser Met Glu Thr Lys Leu Lys Ser Gln Ser Gly Gln Ile 
        915                 920                 925             


Lys Glu Glu Asp Phe Glu Gln Ser Lys Ser Gln Ala Ser Phe Asn Asn 
    930                 935                 940                 


Lys Lys Ser Gly Asp His Cys His Pro Pro Ser Ile Lys His Glu Ser 
945                 950                 955                 960 


Tyr Arg Gly Asn Ala Ser Pro Gly Ala Ala Thr His Asp Ser Leu Ser 
                965                 970                 975     


Asp Tyr Gly Pro Gln Asp Ser Arg Pro Thr Pro Met Arg Arg Val Pro 
            980                 985                 990         


Gly Arg Val Gly Gly Arg Glu Gly  Met Arg Gly Arg Ser  Pro Ser Gln 
        995                 1000                 1005             


Tyr His  Asp Phe Ala Glu Lys  Leu Lys Met Ser Pro  Gly Arg Ser 
    1010                 1015                 1020             


Arg Gly  Pro Gly Gly Asp Pro  His His Met Asn Pro  His Met Thr 
    1025                 1030                 1035             


Phe Ser  Glu Arg Ala Asn Arg  Ser Ser Leu His Thr  Pro Phe Ser 
    1040                 1045                 1050             


Pro Asn  Ser Glu Thr Leu Ala  Ser Ala Tyr His Ala  Asn Thr Arg 
    1055                 1060                 1065             


Ala His  Ala Tyr Gly Asp Pro  Asn Ala Gly Leu Asn  Ser Gln Leu 
    1070                 1075                 1080             


His Tyr  Lys Arg Gln Met Tyr  Gln Gln Gln Pro Glu  Glu Tyr Lys 
    1085                 1090                 1095             


Asp Trp  Ser Ser Gly Ser Ala  Gln Gly Val Ile Ala  Ala Ala Gln 
    1100                 1105                 1110             


His Arg  Gln Glu Gly Pro Arg  Lys Ser Pro Arg Gln  Gln Gln Phe 
    1115                 1120                 1125             


Leu Asp  Arg Val Arg Ser Pro  Leu Lys Asn Asp Lys  Asp Gly Met 
    1130                 1135                 1140             


Met Tyr  Gly Pro Pro Val Gly  Thr Tyr His Asp Pro  Ser Ala Gln 
    1145                 1150                 1155             


Glu Ala  Gly Arg Cys Leu Met  Ser Ser Asp Gly Leu  Pro Asn Lys 
    1160                 1165                 1170             


Gly Met  Glu Leu Lys His Gly  Ser Gln Lys Leu Gln  Glu Ser Cys 
    1175                 1180                 1185             


Trp Asp  Leu Ser Arg Gln Thr  Ser Pro Ala Lys Ser  Ser Gly Pro 
    1190                 1195                 1200             


Pro Gly  Met Ser Ser Gln Lys  Arg Tyr Gly Pro Pro  His Glu Thr 
    1205                 1210                 1215             


Asp Gly  His Gly Leu Ala Glu  Ala Thr Gln Ser Ser  Lys Pro Gly 
    1220                 1225                 1230             


Ser Val  Met Leu Arg Leu Pro  Gly Gln Glu Asp His  Ser Ser Gln 
    1235                 1240                 1245             


Asn Pro  Leu Ile Met Arg Arg  Arg Val Arg Ser Phe  Ile Ser Pro 
    1250                 1255                 1260             


Ile Pro  Ser Lys Arg Gln Ser  Gln Asp Val Lys Asn  Ser Ser Thr 
    1265                 1270                 1275             


Glu Asp  Lys Gly Arg Leu Leu  His Ser Ser Lys Glu  Gly Ala Asp 
    1280                 1285                 1290             


Lys Ala  Phe Asn Ser Tyr Ala  His Leu Ser His Ser  Gln Asp Ile 
    1295                 1300                 1305             


Lys Ser  Ile Pro Lys Arg Asp  Ser Ser Lys Asp Leu  Pro Ser Pro 
    1310                 1315                 1320             


Asp Ser  Arg Asn Cys Pro Ala  Val Thr Leu Thr Ser  Pro Ala Lys 
    1325                 1330                 1335             


Thr Lys  Ile Leu Pro Pro Arg  Lys Gly Arg Gly Leu  Lys Leu Glu 
    1340                 1345                 1350             


Ala Ile  Val Gln Lys Ile Thr  Ser Pro Asn Ile Arg  Arg Ser Ala 
    1355                 1360                 1365             


Ser Ser  Asn Ser Ala Glu Ala  Gly Gly Asp Thr Val  Thr Leu Asp 
    1370                 1375                 1380             


Asp Ile  Leu Ser Leu Lys Ser  Gly Pro Pro Glu Gly  Gly Ser Val 
    1385                 1390                 1395             


Ala Val  Gln Asp Ala Asp Ile  Glu Lys Arg Lys Gly  Glu Val Ala 
    1400                 1405                 1410             


Ser Asp  Leu Val Ser Pro Ala  Asn Gln Glu Leu His  Val Glu Lys 
    1415                 1420                 1425             


Pro Leu  Pro Arg Ser Ser Glu  Glu Trp Arg Gly Ser  Val Asp Asp 
    1430                 1435                 1440             


Lys Val  Lys Thr Glu Thr His  Ala Glu Thr Val Thr  Ala Gly Lys 
    1445                 1450                 1455             


Glu Pro  Pro Gly Ala Met Thr  Ser Thr Thr Ser Gln  Lys Pro Gly 
    1460                 1465                 1470             


Ser Asn  Gln Gly Arg Pro Asp  Gly Ser Leu Gly Gly  Thr Ala Pro 
    1475                 1480                 1485             


Leu Ile  Phe Pro Asp Ser Lys  Asn Val Pro Pro Val  Gly Ile Leu 
    1490                 1495                 1500             


Ala Pro  Glu Ala Asn Pro Lys  Ala Glu Glu Lys Glu  Asn Asp Thr 
    1505                 1510                 1515             


Val Thr  Ile Ser Pro Lys Gln  Glu Gly Phe Pro Pro  Lys Gly Tyr 
    1520                 1525                 1530             


Phe Pro  Ser Gly Lys Lys Lys  Gly Arg Pro Ile Gly  Ser Val Asn 
    1535                 1540                 1545             


Lys Gln  Lys Lys Gln Gln Gln  Pro Pro Pro Pro Pro  Pro Gln Pro 
    1550                 1555                 1560             


Pro Gln  Ile Pro Glu Gly Ser  Ala Asp Gly Glu Pro  Lys Pro Lys 
    1565                 1570                 1575             


Lys Gln  Arg Gln Arg Arg Glu  Arg Arg Lys Pro Gly  Ala Gln Pro 
    1580                 1585                 1590             


Arg Lys  Arg Lys Thr Lys Gln  Ala Val Pro Ile Val  Glu Pro Gln 
    1595                 1600                 1605             


Glu Pro  Glu Ile Lys Leu Lys  Tyr Ala Thr Gln Pro  Leu Asp Lys 
    1610                 1615                 1620             


Thr Asp  Ala Lys Asn Lys Ser  Phe Tyr Pro Tyr Ile  His Val Val 
    1625                 1630                 1635             


Asn Lys  Cys Glu Leu Gly Ala  Val Cys Thr Ile Ile  Asn Ala Glu 
    1640                 1645                 1650             


Glu Glu  Glu Gln Thr Lys Leu  Val Arg Gly Arg Lys  Gly Gln Arg 
    1655                 1660                 1665             


Ser Leu  Thr Pro Pro Pro Ser  Ser Thr Glu Ser Lys  Ala Leu Pro 
    1670                 1675                 1680             


Ala Ser  Ser Phe Met Leu Gln  Gly Pro Val Val Thr  Glu Ser Ser 
    1685                 1690                 1695             


Val Met  Gly His Leu Val Cys  Cys Leu Cys Gly Lys  Trp Ala Ser 
    1700                 1705                 1710             


Tyr Arg  Asn Met Gly Asp Leu  Phe Gly Pro Phe Tyr  Pro Gln Asp 
    1715                 1720                 1725             


Tyr Ala  Ala Thr Leu Pro Lys  Asn Pro Pro Pro Lys  Arg Ala Thr 
    1730                 1735                 1740             


Glu Met  Gln Ser Lys Val Lys  Val Arg His Lys Ser  Ala Ser Asn 
    1745                 1750                 1755             


Gly Ser  Lys Thr Asp Thr Glu  Glu Glu Glu Glu Gln  Gln Gln Gln 
    1760                 1765                 1770             


Gln Lys  Glu Gln Arg Ser Leu  Ala Ala His Pro Arg  Phe Lys Arg 
    1775                 1780                 1785             


Arg His  Arg Ser Glu Asp Cys  Gly Gly Gly Pro Arg  Ser Leu Ser 
    1790                 1795                 1800             


Arg Gly  Leu Pro Cys Lys Lys  Ala Ala Thr Glu Gly  Ser Ser Glu 
    1805                 1810                 1815             


Lys Thr  Val Leu Asp Ser Lys  Pro Ser Val Pro Thr  Thr Ser Glu 
    1820                 1825                 1830             


Gly Gly  Pro Glu Leu Glu Leu  Gln Ile Pro Glu Leu  Pro Leu Asp 
    1835                 1840                 1845             


Ser Asn  Glu Phe Trp Val His  Glu Gly Cys Ile Leu  Trp Ala Asn 
    1850                 1855                 1860             


Gly Ile  Tyr Leu Val Cys Gly  Arg Leu Tyr Gly Leu  Gln Glu Ala 
    1865                 1870                 1875             


Leu Glu  Ile Ala Arg Glu Met  Lys Cys Ser His Cys  Gln Glu Ala 
    1880                 1885                 1890             


Gly Ala  Thr Leu Gly Cys Tyr  Asn Lys Gly Cys Ser  Phe Arg Tyr 
    1895                 1900                 1905             


His Tyr  Pro Cys Ala Ile Asp  Ala Asp Cys Leu Leu  His Glu Glu 
    1910                 1915                 1920             


Asn Phe  Ser Val Arg Cys Pro  Lys His Lys Pro Pro  Leu Pro Cys 
    1925                 1930                 1935             


Pro Leu  Pro Pro Leu Gln Asn  Lys Thr Ala Lys Gly  Ser Leu Ser 
    1940                 1945                 1950             


Thr Glu  Gln Ser Glu Arg Gly  
    1955                 1960 


<210> 247
<211> 2248
<212> PRT
<213> Homo sapiens

<400> 247
Met Lys Asp Lys Arg Lys Lys Lys Asp Arg Thr Trp Ala Glu Ala Ala 
1               5                   10                  15      


Arg Leu Ala Leu Glu Lys His Pro Asn Ser Pro Met Thr Ala Lys Gln 
            20                  25                  30          


Ile Leu Glu Val Ile Gln Lys Glu Gly Leu Lys Glu Thr Ser Gly Thr 
        35                  40                  45              


Ser Pro Leu Ala Cys Leu Asn Ala Met Leu His Thr Asn Thr Arg Ile 
    50                  55                  60                  


Gly Asp Gly Thr Phe Phe Lys Ile Pro Gly Lys Ser Gly Leu Tyr Ala 
65                  70                  75                  80  


Leu Lys Lys Glu Glu Ser Ser Cys Pro Ala Asp Gly Thr Leu Asp Leu 
                85                  90                  95      


Val Cys Glu Ser Glu Leu Asp Gly Thr Asp Met Ala Glu Ala Asn Ala 
            100                 105                 110         


His Gly Glu Glu Asn Gly Val Cys Ser Lys Gln Val Thr Asp Glu Ala 
        115                 120                 125             


Ser Ser Thr Arg Asp Ser Ser Leu Thr Asn Thr Ala Val Gln Ser Lys 
    130                 135                 140                 


Leu Val Ser Ser Phe Gln Gln His Thr Lys Lys Ala Leu Lys Gln Ala 
145                 150                 155                 160 


Leu Arg Gln Gln Gln Lys Arg Arg Asn Gly Val Ser Met Met Val Asn 
                165                 170                 175     


Lys Thr Val Pro Arg Val Val Leu Thr Pro Leu Lys Val Ser Asp Glu 
            180                 185                 190         


Gln Ser Asp Ser Pro Ser Gly Ser Glu Ser Lys Asn Gly Glu Ala Asp 
        195                 200                 205             


Ser Ser Asp Lys Glu Met Lys His Gly Gln Lys Ser Pro Thr Gly Lys 
    210                 215                 220                 


Gln Thr Ser Gln His Leu Lys Arg Leu Lys Lys Ser Gly Leu Gly His 
225                 230                 235                 240 


Leu Lys Trp Thr Lys Ala Glu Asp Ile Asp Ile Glu Thr Pro Gly Ser 
                245                 250                 255     


Ile Leu Val Asn Thr Asn Leu Arg Ala Leu Ile Asn Lys His Thr Phe 
            260                 265                 270         


Ala Ser Leu Pro Gln His Phe Gln Gln Tyr Leu Leu Leu Leu Leu Pro 
        275                 280                 285             


Glu Val Asp Arg Gln Met Gly Ser Asp Gly Ile Leu Arg Leu Ser Thr 
    290                 295                 300                 


Ser Ala Leu Asn Asn Glu Phe Phe Ala Tyr Ala Ala Gln Gly Trp Lys 
305                 310                 315                 320 


Gln Arg Leu Ala Glu Gly Glu Phe Thr Pro Glu Met Gln Leu Arg Ile 
                325                 330                 335     


Arg Gln Glu Ile Glu Lys Glu Lys Lys Thr Glu Pro Trp Lys Glu Lys 
            340                 345                 350         


Phe Phe Glu Arg Phe Tyr Gly Glu Lys Leu Gly Met Ser Arg Glu Glu 
        355                 360                 365             


Ser Val Lys Leu Thr Thr Gly Pro Asn Asn Ala Gly Ala Gln Ser Ser 
    370                 375                 380                 


Ser Ser Cys Gly Thr Ser Gly Leu Pro Val Ser Ala Gln Thr Ala Leu 
385                 390                 395                 400 


Ala Glu Gln Gln Pro Lys Ser Met Lys Ser Pro Ala Ser Pro Glu Pro 
                405                 410                 415     


Gly Phe Cys Ala Thr Leu Cys Pro Met Val Glu Ile Pro Pro Lys Asp 
            420                 425                 430         


Ile Met Ala Glu Leu Glu Ser Glu Asp Ile Leu Ile Pro Glu Glu Ser 
        435                 440                 445             


Val Ile Gln Glu Glu Ile Ala Glu Glu Val Glu Thr Ser Ile Cys Glu 
    450                 455                 460                 


Cys Gln Asp Glu Asn His Lys Thr Ile Pro Glu Phe Ser Glu Glu Ala 
465                 470                 475                 480 


Glu Ser Leu Thr Asn Ser His Glu Glu Pro Gln Ile Ala Pro Pro Glu 
                485                 490                 495     


Asp Asn Leu Glu Ser Cys Val Met Met Asn Asp Val Leu Glu Thr Leu 
            500                 505                 510         


Pro His Ile Glu Val Lys Ile Glu Gly Lys Ser Glu Ser Pro Gln Glu 
        515                 520                 525             


Glu Met Thr Val Val Ile Asp Gln Leu Glu Val Cys Asp Ser Leu Ile 
    530                 535                 540                 


Pro Ser Thr Ser Ser Met Thr His Val Ser Asp Thr Glu His Lys Glu 
545                 550                 555                 560 


Ser Glu Thr Ala Val Glu Thr Ser Thr Pro Lys Ile Lys Thr Gly Ser 
                565                 570                 575     


Ser Ser Leu Glu Gly Gln Phe Pro Asn Glu Gly Ile Ala Ile Asp Met 
            580                 585                 590         


Glu Leu Gln Ser Asp Pro Glu Glu Gln Leu Ser Glu Asn Ala Cys Ile 
        595                 600                 605             


Ser Glu Thr Ser Phe Ser Ser Glu Ser Pro Glu Gly Ala Cys Thr Ser 
    610                 615                 620                 


Leu Pro Ser Pro Gly Gly Glu Thr Gln Ser Thr Ser Glu Glu Ser Cys 
625                 630                 635                 640 


Thr Pro Ala Ser Leu Glu Thr Thr Phe Cys Ser Glu Val Ser Ser Thr 
                645                 650                 655     


Glu Asn Thr Asp Lys Tyr Asn Gln Arg Asn Ser Thr Asp Glu Asn Phe 
            660                 665                 670         


His Ala Ser Leu Met Ser Glu Ile Ser Pro Ile Ser Thr Ser Pro Glu 
        675                 680                 685             


Ile Ser Glu Ala Ser Leu Met Ser Asn Leu Pro Leu Thr Ser Glu Ala 
    690                 695                 700                 


Ser Pro Val Ser Asn Leu Pro Leu Thr Ser Glu Thr Ser Pro Met Ser 
705                 710                 715                 720 


Asp Leu Pro Leu Thr Ser Glu Thr Ser Ser Val Ser Ser Met Leu Leu 
                725                 730                 735     


Thr Ser Glu Thr Thr Phe Val Ser Ser Leu Pro Leu Pro Ser Glu Thr 
            740                 745                 750         


Ser Pro Ile Ser Asn Ser Ser Ile Asn Glu Arg Met Ala His Gln Gln 
        755                 760                 765             


Arg Lys Ser Pro Ser Val Ser Glu Glu Pro Leu Ser Pro Gln Lys Asp 
    770                 775                 780                 


Glu Ser Ser Ala Thr Ala Lys Pro Leu Gly Glu Asn Leu Thr Ser Gln 
785                 790                 795                 800 


Gln Lys Asn Leu Ser Asn Thr Pro Glu Pro Ile Ile Met Ser Ser Ser 
                805                 810                 815     


Ser Ile Ala Pro Glu Ala Phe Pro Ser Glu Asp Leu His Asn Lys Thr 
            820                 825                 830         


Leu Ser Gln Gln Thr Cys Lys Ser His Val Asp Thr Glu Lys Pro Tyr 
        835                 840                 845             


Pro Ala Ser Ile Pro Glu Leu Ala Ser Thr Glu Met Ile Lys Val Lys 
    850                 855                 860                 


Asn His Ser Val Leu Gln Arg Thr Glu Lys Lys Val Leu Pro Ser Pro 
865                 870                 875                 880 


Leu Glu Leu Ser Val Phe Ser Glu Gly Thr Asp Asn Lys Gly Asn Glu 
                885                 890                 895     


Leu Pro Ser Ala Lys Leu Gln Asp Lys Gln Tyr Ile Ser Ser Val Asp 
            900                 905                 910         


Lys Ala Pro Phe Ser Glu Gly Ser Arg Asn Lys Thr His Lys Gln Gly 
        915                 920                 925             


Ser Thr Gln Ser Arg Leu Glu Thr Ser His Thr Ser Lys Ser Ser Glu 
    930                 935                 940                 


Pro Ser Lys Ser Pro Asp Gly Ile Arg Asn Glu Ser Arg Asp Ser Glu 
945                 950                 955                 960 


Ile Ser Lys Arg Lys Thr Ala Glu Gln His Ser Phe Gly Ile Cys Lys 
                965                 970                 975     


Glu Lys Arg Ala Arg Ile Glu Asp Asp Gln Ser Thr Arg Asn Ile Ser 
            980                 985                 990         


Ser Ser Ser Pro Pro Glu Lys Glu  Gln Pro Pro Arg Glu  Glu Pro Arg 
        995                 1000                 1005             


Val Pro  Pro Leu Lys Ile Gln  Leu Ser Lys Ile Gly  Pro Pro Phe 
    1010                 1015                 1020             


Ile Ile  Lys Ser Gln Pro Val  Ser Lys Pro Glu Ser  Arg Ala Ser 
    1025                 1030                 1035             


Thr Ser  Thr Ser Val Ser Gly  Gly Arg Asn Thr Gly  Ala Arg Thr 
    1040                 1045                 1050             


Leu Ala  Asp Ile Lys Ala Arg  Ala Gln Gln Ala Arg  Ala Gln Arg 
    1055                 1060                 1065             


Glu Ala  Ala Ala Ala Ala Ala  Val Ala Ala Ala Ala  Ser Ile Val 
    1070                 1075                 1080             


Ser Gly  Ala Met Gly Ser Pro  Gly Glu Gly Gly Lys  Thr Arg Thr 
    1085                 1090                 1095             


Leu Ala  His Ile Lys Glu Gln  Thr Lys Ala Lys Leu  Phe Ala Lys 
    1100                 1105                 1110             


His Gln  Ala Arg Ala His Leu  Phe Gln Thr Ser Lys  Glu Thr Arg 
    1115                 1120                 1125             


Leu Pro  Pro Pro Leu Ser Ser  Lys Glu Gly Pro Pro  Asn Leu Glu 
    1130                 1135                 1140             


Val Ser  Ser Thr Pro Glu Thr  Lys Met Glu Gly Ser  Thr Gly Val 
    1145                 1150                 1155             


Ile Ile  Val Asn Pro Asn Cys  Arg Ser Pro Ser Asn  Lys Ser Ala 
    1160                 1165                 1170             


His Leu  Arg Glu Thr Thr Thr  Val Leu Gln Gln Ser  Leu Asn Pro 
    1175                 1180                 1185             


Ser Lys  Leu Pro Glu Thr Ala  Thr Asp Leu Ser Val  His Ser Ser 
    1190                 1195                 1200             


Asp Glu  Asn Ile Pro Val Ser  His Leu Ser Glu Lys  Ile Val Ser 
    1205                 1210                 1215             


Ser Thr  Ser Ser Glu Asn Ser  Ser Val Pro Met Leu  Phe Asn Lys 
    1220                 1225                 1230             


Asn Ser  Val Pro Val Ser Val  Cys Ser Thr Ala Ile  Ser Gly Ala 
    1235                 1240                 1245             


Ile Lys  Glu His Pro Phe Val  Ser Ser Val Asp Lys  Ser Ser Val 
    1250                 1255                 1260             


Leu Met  Ser Val Asp Ser Ala  Asn Thr Thr Ile Ser  Ala Cys Asn 
    1265                 1270                 1275             


Ile Ser  Met Leu Lys Thr Ile  Gln Gly Thr Asp Thr  Pro Cys Ile 
    1280                 1285                 1290             


Ala Ile  Ile Pro Lys Cys Ile  Glu Ser Thr Pro Ile  Ser Ala Thr 
    1295                 1300                 1305             


Thr Glu  Gly Ser Ser Ile Ser  Ser Ser Met Asp Asp  Lys Gln Leu 
    1310                 1315                 1320             


Leu Ile  Ser Ser Ser Ser Ala  Ser Asn Leu Val Ser  Thr Gln Tyr 
    1325                 1330                 1335             


Thr Ser  Val Pro Thr Pro Ser  Ile Gly Asn Asn Leu  Pro Asn Leu 
    1340                 1345                 1350             


Ser Thr  Ser Ser Val Leu Ile  Pro Pro Met Gly Ile  Asn Asn Arg 
    1355                 1360                 1365             


Phe Pro  Ser Glu Lys Ile Ala  Ile Pro Gly Ser Glu  Glu Gln Ala 
    1370                 1375                 1380             


Thr Val  Ser Met Gly Thr Thr  Val Arg Ala Ala Leu  Ser Cys Ser 
    1385                 1390                 1395             


Asp Ser  Val Ala Val Thr Asp  Ser Leu Val Ala His  Pro Thr Val 
    1400                 1405                 1410             


Ala Met  Phe Thr Gly Asn Met  Leu Thr Ile Asn Ser  Tyr Asp Ser 
    1415                 1420                 1425             


Pro Pro  Lys Leu Ser Ala Glu  Ser Leu Asp Lys Asn  Ser Gly Pro 
    1430                 1435                 1440             


Arg Asn  Arg Ala Asp Asn Ser  Gly Lys Pro Gln Gln  Pro Pro Gly 
    1445                 1450                 1455             


Gly Phe  Ala Pro Ala Ala Ile  Asn Arg Ser Ile Pro  Cys Lys Val 
    1460                 1465                 1470             


Ile Val  Asp His Ser Thr Thr  Leu Thr Ser Ser Leu  Ser Leu Thr 
    1475                 1480                 1485             


Val Ser  Val Glu Ser Ser Glu  Ala Ser Leu Asp Leu  Gln Gly Arg 
    1490                 1495                 1500             


Pro Val  Arg Thr Glu Ala Ser  Val Gln Pro Val Ala  Cys Pro Gln 
    1505                 1510                 1515             


Val Ser  Val Ile Ser Arg Pro  Glu Pro Val Ala Asn  Glu Gly Ile 
    1520                 1525                 1530             


Asp His  Ser Ser Thr Phe Ile  Ala Ala Ser Ala Ala  Lys Gln Asp 
    1535                 1540                 1545             


Ser Lys  Thr Leu Pro Ala Thr  Cys Thr Ser Leu Arg  Glu Leu Pro 
    1550                 1555                 1560             


Leu Val  Pro Asp Lys Leu Asn  Glu Pro Thr Ala Pro  Ser His Asn 
    1565                 1570                 1575             


Phe Ala  Glu Gln Ala Arg Gly  Pro Ala Pro Phe Lys  Ser Glu Ala 
    1580                 1585                 1590             


Asp Thr  Thr Cys Ser Asn Gln  Tyr Asn Pro Ser Asn  Arg Ile Cys 
    1595                 1600                 1605             


Trp Asn  Asp Asp Gly Met Arg  Ser Thr Gly Gln Pro  Leu Val Thr 
    1610                 1615                 1620             


His Ser  Gly Ser Ser Lys Gln  Lys Glu Tyr Leu Glu  Gln Ser Cys 
    1625                 1630                 1635             


Pro Lys  Ala Ile Lys Thr Glu  His Ala Asn Tyr Leu  Asn Val Ser 
    1640                 1645                 1650             


Glu Leu  His Pro Arg Asn Leu  Val Thr Asn Val Ala  Leu Pro Val 
    1655                 1660                 1665             


Lys Ser  Glu Leu His Glu Ala  Asp Lys Gly Phe Arg  Met Asp Thr 
    1670                 1675                 1680             


Glu Asp  Phe Pro Gly Pro Glu  Leu Pro Pro Pro Ala  Ala Glu Gly 
    1685                 1690                 1695             


Ala Ser  Ser Val Gln Gln Thr  Gln Asn Met Lys Ala  Ser Thr Ser 
    1700                 1705                 1710             


Ser Pro  Met Glu Glu Ala Ile  Ser Leu Ala Thr Asp  Ala Leu Lys 
    1715                 1720                 1725             


Arg Val  Pro Gly Ala Gly Ser  Ser Gly Cys Arg Leu  Ser Ser Val 
    1730                 1735                 1740             


Glu Ala  Asn Asn Pro Leu Val  Thr Gln Leu Leu Gln  Gly Asn Leu 
    1745                 1750                 1755             


Pro Leu  Glu Lys Val Leu Pro  Gln Pro Arg Leu Gly  Ala Lys Leu 
    1760                 1765                 1770             


Glu Ile  Asn Arg Leu Pro Leu  Pro Leu Gln Thr Thr  Ser Val Gly 
    1775                 1780                 1785             


Lys Thr  Ala Pro Glu Arg Asn  Val Glu Ile Pro Pro  Ser Ser Pro 
    1790                 1795                 1800             


Asn Pro  Asp Gly Lys Gly Tyr  Leu Ala Gly Thr Leu  Ala Pro Leu 
    1805                 1810                 1815             


Gln Met  Arg Lys Arg Glu Asn  His Pro Lys Lys Arg  Val Ala Arg 
    1820                 1825                 1830             


Thr Val  Gly Glu His Thr Gln  Val Lys Cys Glu Pro  Gly Lys Leu 
    1835                 1840                 1845             


Leu Val  Glu Pro Asp Val Lys  Gly Val Pro Cys Val  Ile Ser Ser 
    1850                 1855                 1860             


Gly Ile  Ser Gln Leu Gly His  Ser Gln Pro Phe Lys  Gln Glu Trp 
    1865                 1870                 1875             


Leu Asn  Lys His Ser Met Gln  Asn Arg Ile Val His  Ser Pro Glu 
    1880                 1885                 1890             


Val Lys  Gln Gln Lys Arg Leu  Leu Pro Ser Cys Ser  Phe Gln Gln 
    1895                 1900                 1905             


Asn Leu  Phe His Val Asp Lys  Asn Gly Gly Phe His  Thr Asp Ala 
    1910                 1915                 1920             


Gly Thr  Ser His Arg Gln Gln  Phe Tyr Gln Met Pro  Val Ala Ala 
    1925                 1930                 1935             


Arg Gly  Pro Ile Pro Thr Ala  Ala Leu Leu Gln Ala  Ser Ser Lys 
    1940                 1945                 1950             


Thr Pro  Val Gly Cys Asn Ala  Phe Ala Phe Asn Arg  His Leu Glu 
    1955                 1960                 1965             


Gln Lys  Gly Leu Gly Glu Val  Ser Leu Ser Ser Ala  Pro His Gln 
    1970                 1975                 1980             


Leu Arg  Leu Ala Asn Met Leu  Ser Pro Asn Met Pro  Met Lys Glu 
    1985                 1990                 1995             


Gly Asp  Glu Val Gly Gly Thr  Ala His Thr Met Pro  Asn Lys Ala 
    2000                 2005                 2010             


Leu Val  His Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Pro Pro Pro 
    2015                 2020                 2025             


Leu Ala  Leu Pro Pro Pro Pro  Pro Pro Pro Pro Pro  Leu Pro Pro 
    2030                 2035                 2040             


Pro Leu  Pro Asn Ala Glu Val  Pro Ser Asp Gln Lys  Gln Pro Pro 
    2045                 2050                 2055             


Val Thr  Met Glu Thr Thr Lys  Arg Leu Ser Trp Pro  Gln Ser Thr 
    2060                 2065                 2070             


Gly Ile  Cys Ser Asn Ile Lys  Ser Glu Pro Leu Ser  Phe Glu Glu 
    2075                 2080                 2085             


Gly Leu  Ser Ser Ser Cys Glu  Leu Gly Met Lys Gln  Val Ser Tyr 
    2090                 2095                 2100             


Asp Gln  Asn Glu Met Lys Glu  Gln Leu Lys Ala Phe  Ala Leu Lys 
    2105                 2110                 2115             


Ser Ala  Asp Phe Ser Ser Tyr  Leu Leu Ser Glu Pro  Gln Lys Pro 
    2120                 2125                 2130             


Phe Thr  Gln Leu Ala Ala Gln  Lys Met Gln Val Gln  Gln Gln Gln 
    2135                 2140                 2145             


Gln Leu  Cys Gly Asn Tyr Pro  Thr Ile His Phe Gly  Ser Thr Ser 
    2150                 2155                 2160             


Phe Lys  Arg Ala Ala Ser Ala  Ile Glu Lys Ser Ile  Gly Ile Leu 
    2165                 2170                 2175             


Gly Ser  Gly Ser Asn Pro Ala  Thr Gly Leu Ser Gly  Gln Asn Ala 
    2180                 2185                 2190             


Gln Met  Pro Val Gln Asn Phe  Ala Asp Ser Ser Asn  Ala Asp Glu 
    2195                 2200                 2205             


Leu Glu  Leu Lys Cys Ser Cys  Arg Leu Lys Ala Met  Ile Val Cys 
    2210                 2215                 2220             


Lys Gly  Cys Gly Ala Phe Cys  His Asp Asp Cys Ile  Gly Pro Ser 
    2225                 2230                 2235             


Lys Leu  Cys Val Ala Cys Leu  Val Val Arg 
    2240                 2245             


<210> 248
<211> 2004
<212> PRT
<213> Homo sapiens

<400> 248
Met Val Lys Leu Ala Asn Pro Leu Tyr Thr Glu Trp Ile Leu Glu Ala 
1               5                   10                  15      


Ile Lys Lys Val Lys Lys Gln Lys Gln Arg Pro Ser Glu Glu Arg Ile 
            20                  25                  30          


Cys Asn Ala Val Ser Ser Ser His Gly Leu Asp Arg Lys Thr Val Leu 
        35                  40                  45              


Glu Gln Leu Glu Leu Ser Val Lys Asp Gly Thr Ile Leu Lys Val Ser 
    50                  55                  60                  


Asn Lys Gly Leu Asn Ser Tyr Lys Asp Pro Asp Asn Pro Gly Arg Ile 
65                  70                  75                  80  


Ala Leu Pro Lys Pro Arg Asn His Gly Lys Leu Asp Asn Lys Gln Asn 
                85                  90                  95      


Val Asp Trp Asn Lys Leu Ile Lys Arg Ala Val Glu Gly Leu Ala Glu 
            100                 105                 110         


Ser Gly Gly Ser Thr Leu Lys Ser Ile Glu Arg Phe Leu Lys Gly Gln 
        115                 120                 125             


Lys Asp Val Ser Ala Leu Phe Gly Gly Ser Ala Ala Ser Gly Phe His 
    130                 135                 140                 


Gln Gln Leu Arg Leu Ala Ile Lys Arg Ala Ile Gly His Gly Arg Leu 
145                 150                 155                 160 


Leu Lys Asp Gly Pro Leu Tyr Arg Leu Asn Thr Lys Ala Thr Asn Val 
                165                 170                 175     


Asp Gly Lys Glu Ser Cys Glu Ser Leu Ser Cys Leu Pro Pro Val Ser 
            180                 185                 190         


Leu Leu Pro His Glu Lys Asp Lys Pro Val Ala Glu Pro Ile Pro Ile 
        195                 200                 205             


Cys Ser Phe Cys Leu Gly Thr Lys Glu Gln Asn Arg Glu Lys Lys Pro 
    210                 215                 220                 


Glu Glu Leu Ile Ser Cys Ala Asp Cys Gly Asn Ser Gly His Pro Ser 
225                 230                 235                 240 


Cys Leu Lys Phe Ser Pro Glu Leu Thr Val Arg Val Lys Ala Leu Arg 
                245                 250                 255     


Trp Gln Cys Ile Glu Cys Lys Thr Cys Ser Ser Cys Arg Asp Gln Gly 
            260                 265                 270         


Lys Asn Ala Asp Asn Met Leu Phe Cys Asp Ser Cys Asp Arg Gly Phe 
        275                 280                 285             


His Met Glu Cys Cys Asp Pro Pro Leu Thr Arg Met Pro Lys Gly Met 
    290                 295                 300                 


Trp Ile Cys Gln Ile Cys Arg Pro Arg Lys Lys Gly Arg Lys Leu Leu 
305                 310                 315                 320 


Gln Lys Lys Ala Ala Gln Ile Lys Arg Arg Tyr Thr Asn Pro Ile Gly 
                325                 330                 335     


Arg Pro Lys Asn Arg Leu Lys Lys Gln Asn Thr Val Ser Lys Gly Pro 
            340                 345                 350         


Phe Ser Lys Val Arg Thr Gly Pro Gly Arg Gly Arg Lys Arg Lys Ile 
        355                 360                 365             


Thr Leu Ser Ser Gln Ser Ala Ser Ser Ser Ser Glu Glu Gly Tyr Leu 
    370                 375                 380                 


Glu Arg Ile Asp Gly Leu Asp Phe Cys Arg Asp Ser Asn Val Ser Leu 
385                 390                 395                 400 


Lys Phe Asn Lys Lys Thr Lys Gly Leu Ile Asp Gly Leu Thr Lys Phe 
                405                 410                 415     


Phe Thr Pro Ser Pro Asp Gly Arg Lys Ala Arg Gly Glu Val Val Asp 
            420                 425                 430         


Tyr Ser Glu Gln Tyr Arg Ile Arg Lys Arg Gly Asn Arg Lys Ser Ser 
        435                 440                 445             


Thr Ser Asp Trp Pro Thr Asp Asn Gln Asp Gly Trp Asp Gly Lys Gln 
    450                 455                 460                 


Glu Asn Glu Glu Arg Leu Phe Gly Ser Gln Glu Ile Met Thr Glu Lys 
465                 470                 475                 480 


Asp Met Glu Leu Phe Arg Asp Ile Gln Glu Gln Ala Leu Gln Lys Val 
                485                 490                 495     


Gly Val Thr Gly Pro Pro Asp Pro Gln Val Arg Cys Pro Ser Val Ile 
            500                 505                 510         


Glu Phe Gly Lys Tyr Glu Ile His Thr Trp Tyr Ser Ser Pro Tyr Pro 
        515                 520                 525             


Gln Glu Tyr Ser Arg Leu Pro Lys Leu Tyr Leu Cys Glu Phe Cys Leu 
    530                 535                 540                 


Lys Tyr Met Lys Ser Arg Thr Ile Leu Gln Gln His Met Lys Lys Cys 
545                 550                 555                 560 


Gly Trp Phe His Pro Pro Ala Asn Glu Ile Tyr Arg Lys Asn Asn Ile 
                565                 570                 575     


Ser Val Phe Glu Val Asp Gly Asn Val Ser Thr Ile Tyr Cys Gln Asn 
            580                 585                 590         


Leu Cys Leu Leu Ala Lys Leu Phe Leu Asp His Lys Thr Leu Tyr Tyr 
        595                 600                 605             


Asp Val Glu Pro Phe Leu Phe Tyr Val Leu Thr Gln Asn Asp Val Lys 
    610                 615                 620                 


Gly Cys His Leu Val Gly Tyr Phe Ser Lys Glu Lys His Cys Gln Gln 
625                 630                 635                 640 


Lys Tyr Asn Val Ser Cys Ile Met Ile Leu Pro Gln Tyr Gln Arg Lys 
                645                 650                 655     


Gly Tyr Gly Arg Phe Leu Ile Asp Phe Ser Tyr Leu Leu Ser Lys Arg 
            660                 665                 670         


Glu Gly Gln Ala Gly Ser Pro Glu Lys Pro Leu Ser Asp Leu Gly Arg 
        675                 680                 685             


Leu Ser Tyr Met Ala Tyr Trp Lys Ser Val Ile Leu Glu Cys Leu Tyr 
    690                 695                 700                 


His Gln Asn Asp Lys Gln Ile Ser Ile Lys Lys Leu Ser Lys Leu Thr 
705                 710                 715                 720 


Gly Ile Cys Pro Gln Asp Ile Thr Ser Thr Leu His His Leu Arg Met 
                725                 730                 735     


Leu Asp Phe Arg Ser Asp Gln Phe Val Ile Ile Arg Arg Glu Lys Leu 
            740                 745                 750         


Ile Gln Asp His Met Ala Lys Leu Gln Leu Asn Leu Arg Pro Val Asp 
        755                 760                 765             


Val Asp Pro Glu Cys Leu Arg Trp Thr Pro Val Ile Val Ser Asn Ser 
    770                 775                 780                 


Val Val Ser Glu Glu Glu Glu Glu Glu Ala Glu Glu Gly Glu Asn Glu 
785                 790                 795                 800 


Glu Pro Gln Cys Gln Glu Arg Glu Leu Glu Ile Ser Val Gly Lys Ser 
                805                 810                 815     


Val Ser His Glu Asn Lys Glu Gln Asp Ser Tyr Ser Val Glu Ser Glu 
            820                 825                 830         


Lys Lys Pro Glu Val Met Ala Pro Val Ser Ser Thr Arg Leu Ser Lys 
        835                 840                 845             


Gln Val Leu Pro His Asp Ser Leu Pro Ala Asn Ser Gln Pro Ser Arg 
    850                 855                 860                 


Arg Gly Arg Trp Gly Arg Lys Asn Arg Lys Thr Gln Glu Arg Phe Gly 
865                 870                 875                 880 


Asp Lys Asp Ser Lys Leu Leu Leu Glu Glu Thr Ser Ser Ala Pro Gln 
                885                 890                 895     


Glu Gln Tyr Gly Glu Cys Gly Glu Lys Ser Glu Ala Thr Gln Glu Gln 
            900                 905                 910         


Tyr Thr Glu Ser Glu Glu Gln Leu Val Ala Ser Glu Glu Gln Pro Ser 
        915                 920                 925             


Gln Asp Gly Lys Pro Asp Leu Pro Lys Arg Arg Leu Ser Glu Gly Val 
    930                 935                 940                 


Glu Pro Trp Arg Gly Gln Leu Lys Lys Ser Pro Glu Ala Leu Lys Cys 
945                 950                 955                 960 


Arg Leu Thr Glu Gly Ser Glu Arg Leu Pro Arg Arg Tyr Ser Glu Gly 
                965                 970                 975     


Asp Arg Ala Val Leu Arg Gly Phe Ser Glu Ser Ser Glu Glu Glu Glu 
            980                 985                 990         


Glu Pro Glu Ser Pro Arg Ser Ser  Ser Pro Pro Ile Leu  Thr Lys Pro 
        995                 1000                 1005             


Thr Leu  Lys Arg Lys Lys Pro  Phe Leu His Arg Arg  Arg Arg Val 
    1010                 1015                 1020             


Arg Lys  Arg Lys His His Asn  Ser Ser Val Val Thr  Glu Thr Ile 
    1025                 1030                 1035             


Ser Glu  Thr Thr Glu Val Leu  Asp Glu Pro Phe Glu  Asp Ser Asp 
    1040                 1045                 1050             


Ser Glu  Arg Pro Met Pro Arg  Leu Glu Pro Thr Phe  Glu Ile Asp 
    1055                 1060                 1065             


Glu Glu  Glu Glu Glu Glu Asp  Glu Asn Glu Leu Phe  Pro Arg Glu 
    1070                 1075                 1080             


Tyr Phe  Arg Arg Leu Ser Ser  Gln Asp Val Leu Arg  Cys Gln Ser 
    1085                 1090                 1095             


Ser Ser  Lys Arg Lys Ser Lys  Asp Glu Glu Glu Asp  Glu Glu Ser 
    1100                 1105                 1110             


Asp Asp  Ala Asp Asp Thr Pro  Ile Leu Lys Pro Val  Ser Leu Leu 
    1115                 1120                 1125             


Arg Lys  Arg Asp Val Lys Asn  Ser Pro Leu Glu Pro  Asp Thr Ser 
    1130                 1135                 1140             


Thr Pro  Leu Lys Lys Lys Lys  Gly Trp Pro Lys Gly  Lys Ser Arg 
    1145                 1150                 1155             


Lys Pro  Ile His Trp Lys Lys  Arg Pro Gly Arg Lys  Pro Gly Phe 
    1160                 1165                 1170             


Lys Leu  Ser Arg Glu Ile Met  Pro Val Ser Thr Gln  Ala Cys Val 
    1175                 1180                 1185             


Ile Glu  Pro Ile Val Ser Ile  Pro Lys Ala Gly Arg  Lys Pro Lys 
    1190                 1195                 1200             


Ile Gln  Glu Ser Glu Glu Thr  Val Glu Pro Lys Glu  Asp Met Pro 
    1205                 1210                 1215             


Leu Pro  Glu Glu Arg Lys Glu  Glu Glu Glu Met Gln  Ala Glu Ala 
    1220                 1225                 1230             


Glu Glu  Ala Glu Glu Gly Glu  Glu Glu Asp Ala Ala  Ser Ser Glu 
    1235                 1240                 1245             


Val Pro  Ala Ala Ser Pro Ala  Asp Ser Ser Asn Ser  Pro Glu Thr 
    1250                 1255                 1260             


Glu Thr  Lys Glu Pro Glu Val  Glu Glu Glu Glu Glu  Lys Pro Arg 
    1265                 1270                 1275             


Val Ser  Glu Glu Gln Arg Gln  Ser Glu Glu Glu Gln  Gln Glu Leu 
    1280                 1285                 1290             


Glu Glu  Pro Glu Pro Glu Glu  Glu Glu Asp Ala Ala  Ala Glu Thr 
    1295                 1300                 1305             


Ala Gln  Asn Asp Asp His Asp  Ala Asp Asp Glu Asp  Asp Gly His 
    1310                 1315                 1320             


Leu Glu  Ser Thr Lys Lys Lys  Glu Leu Glu Glu Gln  Pro Thr Arg 
    1325                 1330                 1335             


Glu Asp  Val Lys Glu Glu Pro  Gly Val Gln Glu Ser  Phe Leu Asp 
    1340                 1345                 1350             


Ala Asn  Met Gln Lys Ser Arg  Glu Lys Ile Lys Asp  Lys Glu Glu 
    1355                 1360                 1365             


Thr Glu  Leu Asp Ser Glu Glu  Glu Gln Pro Ser His  Asp Thr Ser 
    1370                 1375                 1380             


Val Val  Ser Glu Gln Met Ala  Gly Ser Glu Asp Asp  His Glu Glu 
    1385                 1390                 1395             


Asp Ser  His Thr Lys Glu Glu  Leu Ile Glu Leu Lys  Glu Glu Glu 
    1400                 1405                 1410             


Glu Ile  Pro His Ser Glu Leu  Asp Leu Glu Thr Val  Gln Ala Val 
    1415                 1420                 1425             


Gln Ser  Leu Thr Gln Glu Glu  Ser Ser Glu His Glu  Gly Ala Tyr 
    1430                 1435                 1440             


Gln Asp  Cys Glu Glu Thr Leu  Ala Ala Cys Gln Thr  Leu Gln Ser 
    1445                 1450                 1455             


Tyr Thr  Gln Ala Asp Glu Asp  Pro Gln Met Ser Met  Val Glu Asp 
    1460                 1465                 1470             


Cys His  Ala Ser Glu His Asn  Ser Pro Ile Ser Ser  Val Gln Ser 
    1475                 1480                 1485             


His Pro  Ser Gln Ser Val Arg  Ser Val Ser Ser Pro  Asn Val Pro 
    1490                 1495                 1500             


Ala Leu  Glu Ser Gly Tyr Thr  Gln Ile Ser Pro Glu  Gln Gly Ser 
    1505                 1510                 1515             


Leu Ser  Ala Pro Ser Met Gln  Asn Met Glu Thr Ser  Pro Met Met 
    1520                 1525                 1530             


Asp Val  Pro Ser Val Ser Asp  His Ser Gln Gln Val  Val Asp Ser 
    1535                 1540                 1545             


Gly Phe  Ser Asp Leu Gly Ser  Ile Glu Ser Thr Thr  Glu Asn Tyr 
    1550                 1555                 1560             


Glu Asn  Pro Ser Ser Tyr Asp  Ser Thr Met Gly Gly  Ser Ile Cys 
    1565                 1570                 1575             


Gly Asn  Ser Ser Ser Gln Ser  Ser Cys Ser Tyr Gly  Gly Leu Ser 
    1580                 1585                 1590             


Ser Ser  Ser Ser Leu Thr Gln  Ser Ser Cys Val Val  Thr Gln Gln 
    1595                 1600                 1605             


Met Ala  Ser Met Gly Ser Ser  Cys Ser Met Met Gln  Gln Ser Ser 
    1610                 1615                 1620             


Val Gln  Pro Ala Ala Asn Cys  Ser Ile Lys Ser Pro  Gln Ser Cys 
    1625                 1630                 1635             


Val Val  Glu Arg Pro Pro Ser  Asn Gln Gln Gln Gln  Pro Pro Pro 
    1640                 1645                 1650             


Pro Pro  Pro Gln Gln Pro Gln  Pro Pro Pro Pro Gln  Pro Gln Pro 
    1655                 1660                 1665             


Ala Pro  Gln Pro Pro Pro Pro  Gln Gln Gln Pro Gln  Gln Gln Pro 
    1670                 1675                 1680             


Gln Pro  Gln Pro Gln Gln Pro  Pro Pro Pro Pro Pro  Pro Gln Gln 
    1685                 1690                 1695             


Gln Pro  Pro Leu Ser Gln Cys  Ser Met Asn Asn Ser  Phe Thr Pro 
    1700                 1705                 1710             


Ala Pro  Met Ile Met Glu Ile  Pro Glu Ser Gly Ser  Thr Gly Asn 
    1715                 1720                 1725             


Ile Ser  Ile Tyr Glu Arg Ile  Pro Gly Asp Phe Gly  Ala Gly Ser 
    1730                 1735                 1740             


Tyr Ser  Gln Pro Ser Ala Thr  Phe Ser Leu Ala Lys  Leu Gln Gln 
    1745                 1750                 1755             


Leu Thr  Asn Thr Ile Met Asp  Pro His Ala Met Pro  Tyr Ser His 
    1760                 1765                 1770             


Ser Pro  Ala Val Thr Ser Tyr  Ala Thr Ser Val Ser  Leu Ser Asn 
    1775                 1780                 1785             


Thr Gly  Leu Ala Gln Leu Ala  Pro Ser His Pro Leu  Ala Gly Thr 
    1790                 1795                 1800             


Pro Gln  Ala Gln Ala Thr Met  Thr Pro Pro Pro Asn  Leu Ala Ser 
    1805                 1810                 1815             


Thr Thr  Met Asn Leu Thr Ser  Pro Leu Leu Gln Cys  Asn Met Ser 
    1820                 1825                 1830             


Ala Thr  Asn Ile Gly Ile Pro  His Thr Gln Arg Leu  Gln Gly Gln 
    1835                 1840                 1845             


Met Pro  Val Lys Gly His Ile  Ser Ile Arg Ser Lys  Ser Ala Pro 
    1850                 1855                 1860             


Leu Pro  Ser Ala Ala Ala His  Gln Gln Gln Leu Tyr  Gly Arg Ser 
    1865                 1870                 1875             


Pro Ser  Ala Val Ala Met Gln  Ala Gly Pro Arg Ala  Leu Ala Val 
    1880                 1885                 1890             


Gln Arg  Gly Met Asn Met Gly  Val Asn Leu Met Pro  Thr Pro Ala 
    1895                 1900                 1905             


Tyr Asn  Val Asn Ser Met Asn  Met Asn Thr Leu Asn  Ala Met Asn 
    1910                 1915                 1920             


Ser Tyr  Arg Met Thr Gln Pro  Met Met Asn Ser Ser  Tyr His Ser 
    1925                 1930                 1935             


Asn Pro  Ala Tyr Met Asn Gln  Thr Ala Gln Tyr Pro  Met Gln Met 
    1940                 1945                 1950             


Gln Met  Gly Met Met Gly Ser  Gln Ala Tyr Thr Gln  Gln Pro Met 
    1955                 1960                 1965             


Gln Pro  Asn Pro His Gly Asn  Met Met Tyr Thr Gly  Pro Ser His 
    1970                 1975                 1980             


His Ser  Tyr Met Asn Ala Ala  Gly Val Pro Lys Gln  Ser Leu Asn 
    1985                 1990                 1995             


Gly Pro  Tyr Met Arg Arg 
    2000                 


<210> 249
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 249
Ala His Phe Lys Ile Ser Gly Glu Lys Arg Pro Ser Thr Asp Pro Gly 
1               5                   10                  15      


Lys Lys Ala Lys Asn Pro Lys Lys Lys Lys Lys Lys Asp Pro 
            20                  25                  30  


<210> 250
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 250
Ala His Arg Ala Lys Lys Met Ser Lys Thr His Ala 
1               5                   10          


<210> 251
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 251
Ala Ser Pro Glu Tyr Val Asn Leu Pro Ile Asn Gly Asn Gly 
1               5                   10                  


<210> 252
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 252
Cys Thr Lys Arg Pro Arg Trp 
1               5           


<210> 253
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 253
Asp Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg 
1               5                   10                  15      


<210> 254
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 254
Glu Glu Leu Arg Leu Lys Glu Glu Leu Leu Lys Gly Ile Tyr Ala 
1               5                   10                  15  


<210> 255
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 255
Glu Glu Gln Leu Arg Arg Arg Lys Asn Ser Arg Leu Asn Asn Thr Gly 
1               5                   10                  15      


<210> 256
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 256
Glu Val Leu Lys Val Ile Arg Thr Gly Lys Arg Lys Lys Lys Ala Trp 
1               5                   10                  15      


Lys Arg Met Val Thr Lys Val Cys 
            20                  


<210> 257
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 257
His His His His His His His His His His His His Gln Pro His 
1               5                   10                  15  


<210> 258
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 258
His Lys Lys Lys His Pro Asp Ala Ser Val Asn Phe Ser Glu Phe Ser 
1               5                   10                  15      


Lys 
    


<210> 259
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 259
His Lys Arg Thr Lys Lys Asn Leu Ser 
1               5                   


<210> 260
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 260
Ile Ile Asn Gly Arg Lys Leu Lys Leu Lys Lys Ser Arg Arg Arg Ser 
1               5                   10                  15      


Ser Gln Thr Ser Asn Asn Ser Phe Thr Ser Arg Arg Ser 
            20                  25                  


<210> 261
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 261
Lys Ala Glu Gln Glu Arg Arg Lys 
1               5               


<210> 262
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 262
Lys Glu Lys Arg Lys Arg Arg Glu Glu Leu Phe Ile Glu Gln Lys Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 263
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 263
Lys Lys Gly Lys Asp Glu Trp Phe Ser Arg Gly Lys Lys Pro 
1               5                   10                  


<210> 264
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 264
Lys Lys Gly Pro Ser Val Gln Lys Arg Lys Lys Thr Asn Leu Ser 
1               5                   10                  15  


<210> 265
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 265
Lys Lys Lys Thr Val Ile Asn Asp Leu Leu His Tyr Lys Lys Glu Lys 
1               5                   10                  15      


<210> 266
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 266
Lys Lys Asn Gly Gly Lys Gly Lys Asn Lys Pro Ser Ala Lys Ile Lys 
1               5                   10                  15      


Lys 
    


<210> 267
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 267
Lys Lys Pro Lys Trp Asp Asp Phe Lys Lys Lys Lys Lys 
1               5                   10              


<210> 268
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 268
Lys Lys Arg Lys Lys Asp Asn Leu Ser 
1               5                   


<210> 269
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 269
Lys Lys Arg Arg Lys Arg Arg Arg Lys 
1               5                   


<210> 270
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 270
Lys Lys Arg Arg Arg Arg Ala Arg Lys 
1               5                   


<210> 271
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 271
Lys Lys Ser Lys Arg Gly Arg 
1               5           


<210> 272
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 272
Lys Lys Ser Arg Lys Arg Gly Ser 
1               5               


<210> 273
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 273
Lys Lys Ser Thr Ala Leu Ser Arg Glu Leu Gly Lys Ile Met Arg Arg 
1               5                   10                  15      


Arg 
    


<210> 274
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 274
Lys Lys Ser Tyr Gln Asp Pro Glu Ile Ile Ala His Ser Arg Pro Arg 
1               5                   10                  15      


Lys 
    


<210> 275
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 275
Lys Lys Thr Gly Lys Asn Arg Lys Leu Lys Ser Lys Arg Val Lys Thr 
1               5                   10                  15      


Arg 
    


<210> 276
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 276
Lys Lys Val Ser Ile Ala Gly Gln Ser Gly Lys Leu Trp Arg Trp Lys 
1               5                   10                  15      


Arg 
    


<210> 277

<400> 277
000


<210> 278
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 278
Lys Lys Tyr Glu Asn Val Val Ile Lys Arg Ser Pro Arg Lys Arg Gly 
1               5                   10                  15      


Arg Pro Arg Lys 
            20  


<210> 279
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 279
Lys Asn Lys Lys Arg Lys 
1               5       


<210> 280
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 280
Lys Pro Lys Lys Lys Arg 
1               5       


<210> 281
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 281
Lys Arg Ala Met Lys Asp Asp Ser His Gly Asn Ser Thr Ser Pro Lys 
1               5                   10                  15      


Arg Arg Lys 
            


<210> 282
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 282
Lys Arg Ala Asn Ser Asn Leu Val Ala Ala Tyr Glu Lys Ala Lys Lys 
1               5                   10                  15      


Lys 
    


<210> 283
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 283
Lys Arg Ala Ser Glu Asp Thr Thr Ser Gly Ser Pro Pro Lys Lys Ser 
1               5                   10                  15      


Ser Ala Gly Pro Lys Arg 
            20          


<210> 284
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 284
Lys Arg Phe Lys Arg Arg Trp Met Val Arg Lys Met Lys Thr Lys Lys 
1               5                   10                  15      


<210> 285
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 285
Lys Arg Gly Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys 
1               5                   10                  15      


<210> 286
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 286
Lys Arg Gly Asn Ser Ser Ile Gly Pro Asn Asp Leu Ser Lys Arg Lys 
1               5                   10                  15      


Gln Arg Lys Lys 
            20  


<210> 287
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 287
Lys Arg Ile His Ser Val Ser Leu Ser Gln Ser Gln Ile Asp Pro Ser 
1               5                   10                  15      


Lys Lys Val Lys Arg Ala Lys 
            20              


<210> 288
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 288
Lys Arg Lys Gly Lys Leu Lys Asn Lys Gly Ser Lys Arg Lys Lys 
1               5                   10                  15  


<210> 289
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 289
Lys Arg Arg Arg Arg Arg Arg Arg Glu Lys Arg Lys Arg 
1               5                   10              


<210> 290
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 290
Lys Arg Ser Asn Asp Arg Thr Tyr Ser Pro Glu Glu Glu Lys Gln Arg 
1               5                   10                  15      


Arg Ala 
        


<210> 291
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 291
Lys Arg Thr Val Ala Thr Asn Gly Asp Ala Ser Gly Ala His Arg Ala 
1               5                   10                  15      


Lys Lys Met Ser Lys 
            20      


<210> 292
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 292
Lys Arg Val Tyr Asn Lys Gly Glu Asp Glu Gln Glu His Leu Pro Lys 
1               5                   10                  15      


Gly Lys Lys Arg 
            20  


<210> 293
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 293
Lys Ser Gly Lys Ala Pro Arg Arg Arg Ala Val Ser Met Asp Asn Ser 
1               5                   10                  15      


Asn Lys 
        


<210> 294
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 294
Lys Val Asn Phe Leu Asp Met Ser Leu Asp Asp Ile Ile Ile Tyr Lys 
1               5                   10                  15      


Glu Leu Glu 
            


<210> 295
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 295
Lys Val Gln His Arg Ile Ala Lys Lys Thr Thr Arg Arg Arg Arg 
1               5                   10                  15  


<210> 296
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 296
Leu Ser Pro Ser Leu Ser Pro Leu 
1               5               


<210> 297
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 297
Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210> 298
<211> 52
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 298
Met Pro Gln Asn Glu Tyr Ile Glu Leu His Arg Lys Arg Tyr Gly Tyr 
1               5                   10                  15      


Arg Leu Asp Tyr His Glu Lys Lys Arg Lys Lys Glu Ser Arg Glu Ala 
            20                  25                  30          


His Glu Arg Ser Lys Lys Ala Lys Lys Met Ile Gly Leu Lys Ala Lys 
        35                  40                  45              


Leu Tyr His Lys 
    50          


<210> 299
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 299
Met Val Gln Leu Arg Pro Arg Ala Ser Arg 
1               5                   10  


<210> 300
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 300
Asn Asn Lys Leu Leu Ala Lys Arg Arg Lys Gly Gly Ala Ser Pro Lys 
1               5                   10                  15      


Asp Asp Pro Met Asp Asp Ile Lys 
            20                  


<210> 301
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 301
Asn Tyr Lys Arg Pro Met Asp Gly Thr Tyr Gly Pro Pro Ala Lys Arg 
1               5                   10                  15      


His Glu Gly Glu 
            20  


<210> 302
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 302
Pro Asp Thr Lys Arg Ala Lys Leu Asp Ser Ser Glu Thr Thr Met Val 
1               5                   10                  15      


Lys Lys Lys 
            


<210> 303
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 303
Pro Glu Lys Arg Thr Lys Ile 
1               5           


<210> 304
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 304
Pro Gly Gly Arg Gly Lys Lys Lys 
1               5               


<210> 305
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 305
Pro Gly Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg 
1               5                   10                  15      


Pro Tyr 
        


<210> 306
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 306
Pro Lys Lys Gly Asp Lys Tyr Asp Lys Thr Asp 
1               5                   10      


<210> 307
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 307
Pro Lys Lys Lys Ser Arg Lys 
1               5           


<210> 308
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 308
Pro Lys Lys Asn Lys Pro Glu 
1               5           


<210> 309
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 309
Pro Lys Lys Arg Ala Lys Val 
1               5           


<210> 310
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 310
Pro Lys Pro Lys Lys Leu Lys Val Glu 
1               5                   


<210> 311
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 311
Pro Lys Arg Gly Arg Gly Arg 
1               5           


<210> 312
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 312
Pro Lys Arg Arg Leu Val Asp Asp Ala 
1               5                   


<210> 313
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 313
Pro Lys Arg Arg Arg Thr Tyr 
1               5           


<210> 314
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 314
Pro Leu Phe Lys Arg Arg 
1               5       


<210> 315
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 315
Pro Leu Arg Lys Ala Lys Arg 
1               5           


<210> 316
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 316
Pro Pro Ala Lys Arg Lys Cys Ile Phe 
1               5                   


<210> 317
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 317
Pro Pro Ala Arg Arg Arg Arg Leu 
1               5               


<210> 318
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 318
Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


<210> 319
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 319
Pro Pro Asn Lys Arg Met Lys Val Lys His 
1               5                   10  


<210> 320
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 320
Pro Pro Arg Ile Tyr Pro Gln Leu Pro Ser Ala Pro Thr 
1               5                   10              


<210> 321
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 321
Pro Gln Arg Ser Pro Phe Pro Lys Ser Ser Val Lys Arg 
1               5                   10              


<210> 322
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 322
Pro Arg Pro Arg Lys Val Pro Arg 
1               5               


<210> 323
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 323
Pro Arg Arg Arg Val Gln Arg Lys Arg 
1               5                   


<210> 324
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 324
Pro Arg Arg Val Arg Leu Lys 
1               5           


<210> 325
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 325
Pro Ser Arg Lys Arg Pro Arg 
1               5           


<210> 326
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 326
Pro Ser Ser Lys Lys Arg Lys Val 
1               5               


<210> 327
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 327
Pro Thr Lys Lys Arg Val Lys 
1               5           


<210> 328
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 328
Gln Arg Pro Gly Pro Tyr Asp Arg Pro 
1               5                   


<210> 329
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 329
Arg Gly Lys Gly Gly Lys Gly Leu Gly Lys Gly Gly Ala Lys Arg His 
1               5                   10                  15      


Arg Lys 
        


<210> 330
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 330
Arg Lys Ala Gly Lys Gly Gly Gly Gly His Lys Thr Thr Lys Lys Arg 
1               5                   10                  15      


Ser Ala Lys Asp Glu Lys Val Pro 
            20                  


<210> 331
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 331
Arg Lys Ile Lys Leu Lys Arg Ala Lys 
1               5                   


<210> 332
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 332
Arg Lys Ile Lys Arg Lys Arg Ala Lys 
1               5                   


<210> 333
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 333
Arg Lys Lys Glu Ala Pro Gly Pro Arg Glu Glu Leu Arg Ser Arg Gly 
1               5                   10                  15      


Arg 
    


<210> 334
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 334
Arg Lys Lys Arg Lys Gly Lys 
1               5           


<210> 335
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 335
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210> 336
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 336
Arg Lys Lys Ser Ile Pro Leu Ser Ile Lys Asn Leu Lys Arg Lys His 
1               5                   10                  15      


Lys Arg Lys Lys Asn Lys Ile Thr Arg 
            20                  25  


<210> 337
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 337
Arg Lys Leu Val Lys Pro Lys Asn Thr Lys Met Lys Thr Lys Leu Arg 
1               5                   10                  15      


Thr Asn Pro Tyr 
            20  


<210> 338
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 338
Arg Lys Arg Leu Ile Leu Ser Asp Lys Gly Gln Leu Asp Trp Lys Lys 
1               5                   10                  15      


<210> 339
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 339
Arg Lys Arg Leu Lys Ser Lys 
1               5           


<210> 340
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 340
Arg Lys Arg Arg Val Arg Asp Asn Met 
1               5                   


<210> 341
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 341
Arg Lys Arg Ser Pro Lys Asp Lys Lys Glu Lys Asp Leu Asp Gly Ala 
1               5                   10                  15      


Gly Lys Arg Arg Lys Thr 
            20          


<210> 342
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 342
Arg Lys Arg Thr Pro Arg Val Asp Gly Gln Thr Gly Glu Asn Asp Met 
1               5                   10                  15      


Asn Lys Arg Arg Arg Lys 
            20          


<210> 343
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 343
Arg Leu Pro Val Arg Arg Arg Arg Arg Arg 
1               5                   10  


<210> 344
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 344
Arg Leu Arg Phe Arg Lys Pro Lys Ser Lys 
1               5                   10  


<210> 345
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 345
Arg Gln Gln Arg Lys Arg 
1               5       


<210> 346
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 346
Arg Arg Asp Leu Asn Ser Ser Phe Glu Thr Ser Pro Lys Lys Val Lys 
1               5                   10                  15      


<210> 347
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 347
Arg Arg Asp Arg Ala Lys Leu Arg 
1               5               


<210> 348
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 348
Arg Arg Gly Asp Gly Arg Arg Arg 
1               5               


<210> 349
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 349
Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln 
1               5                   10      


<210> 350
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 350
Arg Arg Lys Lys Arg Arg 
1               5       


<210> 351
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 351
Arg Arg Lys Arg Ser Lys Ser Glu Asp Met Asp Ser Val Glu Ser Lys 
1               5                   10                  15      


Arg Arg Arg 
            


<210> 352
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 352
Arg Arg Lys Arg Ser Arg 
1               5       


<210> 353
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 353
Arg Arg Pro Lys Gly Lys Thr Leu Gln Lys Arg Lys Pro Lys 
1               5                   10                  


<210> 354
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 354
Arg Arg Arg Gly Phe Glu Arg Phe Gly Pro Asp Asn Met Gly Arg Lys 
1               5                   10                  15      


Arg Lys 
        


<210> 355
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 355
Arg Arg Arg Gly Lys Asn Lys Val Ala Ala Gln Asn Cys Arg Lys 
1               5                   10                  15  


<210> 356
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 356
Arg Arg Arg Lys Arg Arg Asn Leu Ser 
1               5                   


<210> 357
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 357
Arg Arg Arg Gln Lys Gln Lys Gly Gly Ala Ser Arg Arg Arg 
1               5                   10                  


<210> 358
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 358
Arg Arg Arg Arg Glu Gly Pro Arg Ala Arg Arg Arg Arg 
1               5                   10              


<210> 359
<211> 61
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 359
Arg Arg Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser 
1               5                   10                  15      


Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe 
            20                  25                  30          


His Lys Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly 
        35                  40                  45              


Arg Met Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu 
    50                  55                  60      


<210> 360
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 360
Arg Arg Val Pro Gln Arg Lys Glu Val Ser Arg Cys Arg Lys Cys Arg 
1               5                   10                  15      


Lys 
    


<210> 361
<211> 32
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 361
Arg Val Gly Gly Arg Arg Gln Ala Val Glu Cys Ile Glu Asp Leu Leu 
1               5                   10                  15      


Asn Glu Pro Gly Gln Pro Leu Asp Leu Ser Cys Lys Arg Pro Arg Pro 
            20                  25                  30          


<210> 362
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 362
Arg Val Val Lys Leu Arg Ile Ala Pro 
1               5                   


<210> 363
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 363
Arg Val Val Arg Arg Arg 
1               5       


<210> 364
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 364
Ser Lys Arg Lys Thr Lys Ile Ser Arg Lys Thr Arg 
1               5                   10          


<210> 365
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 365
Ser Tyr Val Lys Thr Val Pro Asn Arg Thr Arg Thr Tyr Ile Lys Leu 
1               5                   10                  15      


<210> 366
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 366
Thr Gly Lys Asn Glu Ala Lys Lys Arg Lys Ile Ala 
1               5                   10          


<210> 367
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 367
Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser Val Ser Cys Pro Val Ile 
1               5                   10                  15      


Pro Ala Ser Thr Asp Glu Ser Pro Gly Ser Ala Leu Asn Ile 
            20                  25                  30  


<210> 368
<211> 770
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 368
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210> 369
<211> 571
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 369
Met Ala Leu Pro Arg Pro Ser Glu Ala Val Pro Gln Asp Lys Val Cys 
1               5                   10                  15      


Tyr Pro Pro Glu Ser Ser Pro Gln Asn Leu Ala Ala Tyr Tyr Thr Pro 
            20                  25                  30          


Phe Pro Ser Tyr Gly His Tyr Arg Asn Ser Leu Ala Thr Val Glu Glu 
        35                  40                  45              


Asp Phe Gln Pro Phe Arg Gln Leu Glu Ala Ala Ala Ser Ala Ala Pro 
    50                  55                  60                  


Ala Met Pro Pro Phe Pro Phe Arg Met Ala Pro Pro Leu Leu Ser Pro 
65                  70                  75                  80  


Gly Leu Gly Leu Gln Arg Glu Pro Leu Tyr Asp Leu Pro Trp Tyr Ser 
                85                  90                  95      


Lys Leu Pro Pro Trp Tyr Pro Ile Pro His Val Pro Arg Glu Val Pro 
            100                 105                 110         


Pro Phe Leu Ser Ser Ser His Glu Tyr Ala Gly Ala Ser Ser Glu Asp 
        115                 120                 125             


Leu Gly His Gln Ile Ile Gly Gly Asp Asn Glu Ser Gly Pro Cys Cys 
    130                 135                 140                 


Gly Pro Asp Thr Leu Ile Pro Pro Pro Pro Ala Asp Ala Ser Leu Leu 
145                 150                 155                 160 


Pro Glu Gly Leu Arg Thr Ser Gln Leu Leu Pro Cys Ser Pro Ser Lys 
                165                 170                 175     


Gln Ser Glu Asp Gly Pro Lys Pro Ser Asn Gln Glu Gly Lys Ser Pro 
            180                 185                 190         


Ala Arg Phe Gln Phe Thr Glu Glu Asp Leu His Phe Val Leu Tyr Gly 
        195                 200                 205             


Val Thr Pro Ser Leu Glu His Pro Ala Ser Leu His His Ala Ile Ser 
    210                 215                 220                 


Gly Leu Leu Val Pro Pro Asp Ser Ser Gly Ser Asp Ser Leu Pro Gln 
225                 230                 235                 240 


Thr Leu Asp Lys Asp Ser Leu Gln Leu Pro Glu Gly Leu Cys Leu Met 
                245                 250                 255     


Gln Thr Val Phe Gly Glu Val Pro His Phe Gly Val Phe Cys Ser Ser 
            260                 265                 270         


Phe Ile Ala Lys Gly Val Arg Phe Gly Pro Phe Gln Gly Lys Val Val 
        275                 280                 285             


Asn Ala Ser Glu Val Lys Thr Tyr Gly Asp Asn Ser Val Met Trp Glu 
    290                 295                 300                 


Ile Phe Glu Asp Gly His Leu Ser His Phe Ile Asp Gly Lys Gly Gly 
305                 310                 315                 320 


Thr Gly Asn Trp Met Ser Tyr Val Asn Cys Ala Arg Phe Pro Lys Glu 
                325                 330                 335     


Gln Asn Leu Val Ala Val Gln Cys Gln Gly His Ile Phe Tyr Glu Ser 
            340                 345                 350         


Cys Lys Glu Ile His Gln Asn Gln Glu Leu Leu Val Trp Tyr Gly Asp 
        355                 360                 365             


Cys Tyr Glu Lys Phe Leu Asp Ile Pro Val Ser Leu Gln Val Thr Glu 
    370                 375                 380                 


Pro Gly Lys Gln Pro Ser Gly Pro Ser Glu Glu Ser Ala Glu Gly Tyr 
385                 390                 395                 400 


Arg Cys Glu Arg Cys Gly Lys Val Phe Thr Tyr Lys Tyr Tyr Arg Asp 
                405                 410                 415     


Lys His Leu Lys Tyr Thr Pro Cys Val Asp Lys Gly Asp Arg Lys Phe 
            420                 425                 430         


Pro Cys Ser Leu Cys Lys Arg Ser Phe Glu Lys Arg Asp Arg Leu Arg 
        435                 440                 445             


Ile His Ile Leu His Val His Glu Lys His Arg Pro His Lys Cys Ser 
    450                 455                 460                 


Thr Cys Gly Lys Cys Phe Ser Gln Ser Ser Ser Leu Asn Lys His Met 
465                 470                 475                 480 


Arg Val His Ser Gly Asp Arg Pro Tyr Gln Cys Val Tyr Cys Thr Lys 
                485                 490                 495     


Arg Phe Thr Ala Ser Ser Ile Leu Arg Thr His Ile Arg Gln His Ser 
            500                 505                 510         


Gly Glu Lys Pro Phe Lys Cys Lys Tyr Cys Gly Lys Ser Phe Ala Ser 
        515                 520                 525             


His Ala Ala His Asp Ser His Val Arg Arg Ser His Lys Glu Asp Asp 
    530                 535                 540                 


Gly Cys Ser Cys Ser Ile Cys Gly Lys Ile Phe Ser Asp Gln Glu Thr 
545                 550                 555                 560 


Phe Tyr Ser His Met Lys Phe His Glu Asp Tyr 
                565                 570     


<210> 370
<211> 334
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 370
Met Ala Thr Glu Glu Lys Lys Pro Glu Thr Glu Ala Ala Arg Ala Gln 
1               5                   10                  15      


Pro Thr Pro Ser Ser Ser Ala Thr Gln Ser Lys Pro Thr Pro Val Lys 
            20                  25                  30          


Pro Asn Tyr Ala Leu Lys Phe Thr Leu Ala Gly His Thr Lys Ala Val 
        35                  40                  45              


Ser Ser Val Lys Phe Ser Pro Asn Gly Glu Trp Leu Ala Ser Ser Ser 
    50                  55                  60                  


Ala Asp Lys Leu Ile Lys Ile Trp Gly Ala Tyr Asp Gly Lys Phe Glu 
65                  70                  75                  80  


Lys Thr Ile Ser Gly His Lys Leu Gly Ile Ser Asp Val Ala Trp Ser 
                85                  90                  95      


Ser Asp Ser Asn Leu Leu Val Ser Ala Ser Asp Asp Lys Thr Leu Lys 
            100                 105                 110         


Ile Trp Asp Val Ser Ser Gly Lys Cys Leu Lys Thr Leu Lys Gly His 
        115                 120                 125             


Ser Asn Tyr Val Phe Cys Cys Asn Phe Asn Pro Gln Ser Asn Leu Ile 
    130                 135                 140                 


Val Ser Gly Ser Phe Asp Glu Ser Val Arg Ile Trp Asp Val Lys Thr 
145                 150                 155                 160 


Gly Lys Cys Leu Lys Thr Leu Pro Ala His Ser Asp Pro Val Ser Ala 
                165                 170                 175     


Val His Phe Asn Arg Asp Gly Ser Leu Ile Val Ser Ser Ser Tyr Asp 
            180                 185                 190         


Gly Leu Cys Arg Ile Trp Asp Thr Ala Ser Gly Gln Cys Leu Lys Thr 
        195                 200                 205             


Leu Ile Asp Asp Asp Asn Pro Pro Val Ser Phe Val Lys Phe Ser Pro 
    210                 215                 220                 


Asn Gly Lys Tyr Ile Leu Ala Ala Thr Leu Asp Asn Thr Leu Lys Leu 
225                 230                 235                 240 


Trp Asp Tyr Ser Lys Gly Lys Cys Leu Lys Thr Tyr Thr Gly His Lys 
                245                 250                 255     


Asn Glu Lys Tyr Cys Ile Phe Ala Asn Phe Ser Val Thr Gly Gly Lys 
            260                 265                 270         


Trp Ile Val Ser Gly Ser Glu Asp Asn Leu Val Tyr Ile Trp Asn Leu 
        275                 280                 285             


Gln Thr Lys Glu Ile Val Gln Lys Leu Gln Gly His Thr Asp Val Val 
    290                 295                 300                 


Ile Ser Thr Ala Cys His Pro Thr Glu Asn Ile Ile Ala Ser Ala Ala 
305                 310                 315                 320 


Leu Glu Asn Asp Lys Thr Ile Lys Leu Trp Lys Ser Asp Cys 
                325                 330                 


<210> 371
<211> 434
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 371
Met Glu Val Arg Pro Lys Glu Ser Trp Asn His Ala Asp Phe Val His 
1               5                   10                  15      


Cys Glu Asp Thr Glu Ser Val Pro Gly Lys Pro Ser Val Asn Ala Asp 
            20                  25                  30          


Glu Glu Val Gly Gly Pro Gln Ile Cys Arg Val Cys Gly Asp Lys Ala 
        35                  40                  45              


Thr Gly Tyr His Phe Asn Val Met Thr Cys Glu Gly Cys Lys Gly Phe 
    50                  55                  60                  


Phe Arg Arg Ala Met Lys Arg Asn Ala Arg Leu Arg Cys Pro Phe Arg 
65                  70                  75                  80  


Lys Gly Ala Cys Glu Ile Thr Arg Lys Thr Arg Arg Gln Cys Gln Ala 
                85                  90                  95      


Cys Arg Leu Arg Lys Cys Leu Glu Ser Gly Met Lys Lys Glu Met Ile 
            100                 105                 110         


Met Ser Asp Glu Ala Val Glu Glu Arg Arg Ala Leu Ile Lys Arg Lys 
        115                 120                 125             


Lys Ser Glu Arg Thr Gly Thr Gln Pro Leu Gly Val Gln Gly Leu Thr 
    130                 135                 140                 


Glu Glu Gln Arg Met Met Ile Arg Glu Leu Met Asp Ala Gln Met Lys 
145                 150                 155                 160 


Thr Phe Asp Thr Thr Phe Ser His Phe Lys Asn Phe Arg Leu Pro Gly 
                165                 170                 175     


Val Leu Ser Ser Gly Cys Glu Leu Pro Glu Ser Leu Gln Ala Pro Ser 
            180                 185                 190         


Arg Glu Glu Ala Ala Lys Trp Ser Gln Val Arg Lys Asp Leu Cys Ser 
        195                 200                 205             


Leu Lys Val Ser Leu Gln Leu Arg Gly Glu Asp Gly Ser Val Trp Asn 
    210                 215                 220                 


Tyr Lys Pro Pro Ala Asp Ser Gly Gly Lys Glu Ile Phe Ser Leu Leu 
225                 230                 235                 240 


Pro His Met Ala Asp Met Ser Thr Tyr Met Phe Lys Gly Ile Ile Ser 
                245                 250                 255     


Phe Ala Lys Val Ile Ser Tyr Phe Arg Asp Leu Pro Ile Glu Asp Gln 
            260                 265                 270         


Ile Ser Leu Leu Lys Gly Ala Ala Phe Glu Leu Cys Gln Leu Arg Phe 
        275                 280                 285             


Asn Thr Val Phe Asn Ala Glu Thr Gly Thr Trp Glu Cys Gly Arg Leu 
    290                 295                 300                 


Ser Tyr Cys Leu Glu Asp Thr Ala Gly Gly Phe Gln Gln Leu Leu Leu 
305                 310                 315                 320 


Glu Pro Met Leu Lys Phe His Tyr Met Leu Lys Lys Leu Gln Leu His 
                325                 330                 335     


Glu Glu Glu Tyr Val Leu Met Gln Ala Ile Ser Leu Phe Ser Pro Asp 
            340                 345                 350         


Arg Pro Gly Val Leu Gln His Arg Val Val Asp Gln Leu Gln Glu Gln 
        355                 360                 365             


Phe Ala Ile Thr Leu Lys Ser Tyr Ile Glu Cys Asn Arg Pro Gln Pro 
    370                 375                 380                 


Ala His Arg Phe Leu Phe Leu Lys Ile Met Ala Met Leu Thr Glu Leu 
385                 390                 395                 400 


Arg Ser Ile Asn Ala Gln His Thr Gln Arg Leu Leu Arg Ile Gln Asp 
                405                 410                 415     


Ile His Pro Phe Ala Thr Pro Leu Met Gln Glu Leu Phe Gly Ile Thr 
            420                 425                 430         


Gly Ser 
        


<210> 372
<211> 238
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 372
Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210> 373
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 373
Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


<210> 374
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 374
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210> 375
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 375
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 376
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 376
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 377
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 377
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 378
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 378
Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Val Asn Arg Tyr 
            20                  25                  30          


Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Trp Val 
        35                  40                  45              


Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser Tyr Glu Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Arg Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210> 379
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 379
Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
            20                  25                  30          


Phe Tyr His Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Tyr Val Ser Tyr 
65                  70                  75                  80  


Pro Glu Tyr Tyr Phe Pro Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95  


<210> 380
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 380
Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Asp 
            20                  25                  30          


Leu Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Lys Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Gln Tyr Tyr Tyr 
65                  70                  75                  80  


Arg Gly Trp Tyr Val Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95  


<210> 381
<211> 98
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 381
Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Val 
            20                  25                  30          


His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Lys Phe Lys Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Tyr Gln Gly Gly 
65                  70                  75                  80  


Gly Arg Trp His Pro Tyr Gly Tyr Tyr Ser Pro Ile Ser Ile Asn Tyr 
                85                  90                  95      


Arg Thr 
        


<210> 382
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 382
Ala Ser Thr Ser Gly Ser Thr His Tyr Tyr Lys Gln Thr Ala Asp Leu 
1               5                   10                  15      


Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Pro Pro 
            20                  25                  30          


Pro Tyr Tyr Val Glu Gly Val Thr Val Phe Arg Ile Thr Tyr Gly Glu 
        35                  40                  45              


Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Tyr Trp Thr 
    50                  55                  60                  


Glu Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile 
65                  70                  75                  80  


Thr Val Tyr Ala Glu Met Tyr Pro Gly Ser Pro Trp Ala Gly Gln Val 
                85                  90                  95      


Met Asp Ile Gln Pro Ile Ser Ile Asn Tyr Arg Thr Glu Gly Ser Gly 
            100                 105                 110         


Ser 
    


<210> 383
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 383
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 384
<211> 195
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 384
Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu Lys Gln Asp Lys 
1               5                   10                  15      


Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile Ile Pro Asp Gly 
            20                  25                  30          


Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr Gly Asp Gln Ser 
        35                  40                  45              


Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr Ile Ala Asp His 
    50                  55                  60                  


Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val Gly Glu Phe Ile 
65                  70                  75                  80  


Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr Pro Glu Leu Leu 
                85                  90                  95      


Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu Thr Thr Gly Gly 
            100                 105                 110         


Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His Tyr Leu Gly Pro 
        115                 120                 125             


Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp Leu Ser Asn Gly 
    130                 135                 140                 


His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro Asn Pro Glu Tyr Asp 
145                 150                 155                 160 


Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys Arg Asp Glu Glu Leu 
                165                 170                 175     


Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met Tyr Ile Glu Gln Asn 
            180                 185                 190         


Ala Cys Ser 
        195 


<210> 385
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 385
Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys Asn Arg Met Lys 
1               5                   10                  15      


Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly Val Val Glu Gly 
            20                  25                  30          


Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly Gly Asp Ile Ala 
        35                  40                  45              


Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn Arg Pro Ser Ala 
    50                  55                  60                  


Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile Arg Phe Gln Arg 
65                  70                  75                  80  


Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser Gln Gln Ala Ala 
                85                  90                  95      


Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr Glu Gln Ile Arg 
            100                 105                 110         


Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly Asp Phe Ala Cys 
        115                 120                 125             


Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro Ala Asp Ile Glu 
    130                 135                 140                 


Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp Glu Val Leu Asp 
145                 150                 155                 160 


Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro Ile Ile Asn Trp 
                165                 170                 175     


Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu Tyr Ala Leu Trp 
            180                 185                 190         


Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val Leu Gln Ala Thr 
        195                 200                 205             


Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys Ala Leu His Asp 
    210                 215                 220                 


Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg Trp Lys Asp Trp 
225                 230                 235                 240 


Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe Ser Leu Arg Glu 
                245                 250                 255     


Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser Leu Ala Ser Gln 
            260                 265                 270         


Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val Leu Ala His Ile 
        275                 280                 285             


Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr Tyr Lys Ser Phe 
    290                 295                 300                 


Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly Val Tyr Leu Pro 
305                 310                 315                 320 


Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro Ile Ala Leu Gly 
                325                 330                 335     


Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met Glu Asn Asp Gly 
            340                 345                 350         


Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr Asp Asp Asp Val 
        355                 360                 365             


Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg Lys Leu Leu His 
    370                 375                 380                 


Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu Glu Gln Gln Glu 
385                 390                 395                 400 


Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr Glu Gly Gly Val 
                405                 410                 415     


Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn His Pro Leu Val 
            420                 425                 430         


Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg Gln Ile Arg Pro 
        435                 440                 445             


Cys Thr Ser Leu Ser 
    450             


<210> 386
<211> 370
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 386
Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu Gly Ser Gly His 
1               5                   10                  15      


Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu Asn Ala Val Leu 
            20                  25                  30          


Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe Cys Leu Arg Arg 
        35                  40                  45              


Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala Gln Glu Leu Thr 
    50                  55                  60                  


Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His Pro Asp Ser Cys 
65                  70                  75                  80  


Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe Gln Lys Tyr Val 
                85                  90                  95      


Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln Glu Phe Leu Lys 
            100                 105                 110         


Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg Arg Gly Arg Arg 
        115                 120                 125             


Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser Pro Pro Arg Arg 
    130                 135                 140                 


Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp Asp Asp Arg Ala 
145                 150                 155                 160 


Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp Ser Lys Ile Val 
                165                 170                 175     


Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys Cys Gln Ala Cys 
            180                 185                 190         


Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp Leu Ser Leu Pro 
        195                 200                 205             


Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser Leu Arg Asp Cys 
    210                 215                 220                 


Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser Glu Asn Ala Pro 
225                 230                 235                 240 


Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr Lys Lys Leu Thr 
                245                 250                 255     


Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu Asn Arg Phe Ser 
            260                 265                 270         


Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly Val Asp Phe Pro 
        275                 280                 285             


Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp Lys Ala Gly Ser 
    290                 295                 300                 


Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser Gly Ser Val His 
305                 310                 315                 320 


Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr Gly Trp His Val 
                325                 330                 335     


Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn Gln Val Ala Ser 
            340                 345                 350         


Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln Glu Pro Pro Arg 
        355                 360                 365             


Cys Leu 
    370 


<210> 387
<211> 175
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 387
Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu Gly Leu Tyr Arg Lys 
1               5                   10                  15      


Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg Ala Val Ala Glu Gln 
            20                  25                  30          


Val Leu His Ser Gln Ser Arg His Val Glu Val Arg Met Ala Cys Ile 
        35                  40                  45              


His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala Phe Ile Glu Gly 
    50                  55                  60                  


Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro Gln Glu Trp Val 
65                  70                  75                  80  


Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr Arg Lys Asp Phe 
                85                  90                  95      


Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln Val Thr Glu Asn 
            100                 105                 110         


Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn Gly Asn His Tyr 
        115                 120                 125             


Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser Ala Met Cys Gln 
    130                 135                 140                 


Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe Lys Thr Asp Val 
145                 150                 155                 160 


Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val Ala Asp Glu 
                165                 170                 175 


<210> 388
<211> 520
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 388
Met Glu Cys Pro His Leu Ser Ser Ser Val Cys Ile Ala Pro Asp Ser 
1               5                   10                  15      


Ala Lys Phe Pro Asn Gly Ser Pro Ser Ser Trp Cys Cys Ser Val Cys 
            20                  25                  30          


Arg Ser Asn Lys Ser Pro Trp Val Cys Leu Thr Cys Ser Ser Val His 
        35                  40                  45              


Cys Gly Arg Tyr Val Asn Gly His Ala Lys Lys His Tyr Glu Asp Ala 
    50                  55                  60                  


Gln Val Pro Leu Thr Asn His Lys Lys Ser Glu Lys Gln Asp Lys Val 
65                  70                  75                  80  


Gln His Thr Val Cys Met Asp Cys Ser Ser Tyr Ser Thr Tyr Cys Tyr 
                85                  90                  95      


Arg Cys Asp Asp Phe Val Val Asn Asp Thr Lys Leu Gly Leu Val Gln 
            100                 105                 110         


Lys Val Arg Glu His Leu Gln Asn Leu Glu Asn Ser Ala Phe Thr Ala 
        115                 120                 125             


Asp Arg His Lys Lys Arg Lys Leu Leu Glu Asn Ser Thr Leu Asn Ser 
    130                 135                 140                 


Lys Leu Leu Lys Val Asn Gly Ser Thr Thr Ala Ile Cys Ala Thr Gly 
145                 150                 155                 160 


Leu Arg Asn Leu Gly Asn Thr Cys Phe Met Asn Ala Ile Leu Gln Ser 
                165                 170                 175     


Leu Ser Asn Ile Glu Gln Phe Cys Cys Tyr Phe Lys Glu Leu Pro Ala 
            180                 185                 190         


Val Glu Leu Arg Asn Gly Lys Thr Ala Gly Arg Arg Thr Tyr His Thr 
        195                 200                 205             


Arg Ser Gln Gly Asp Asn Asn Val Ser Leu Val Glu Glu Phe Arg Lys 
    210                 215                 220                 


Thr Leu Cys Ala Leu Trp Gln Gly Ser Gln Thr Ala Phe Ser Pro Glu 
225                 230                 235                 240 


Ser Leu Phe Tyr Val Val Trp Lys Ile Met Pro Asn Phe Arg Gly Tyr 
                245                 250                 255     


Gln Gln Gln Asp Ala His Glu Phe Met Arg Tyr Leu Leu Asp His Leu 
            260                 265                 270         


His Leu Glu Leu Gln Gly Gly Phe Asn Gly Val Ser Arg Ser Ala Ile 
        275                 280                 285             


Leu Gln Glu Asn Ser Thr Leu Ser Ala Ser Asn Lys Cys Cys Ile Asn 
    290                 295                 300                 


Gly Ala Ser Thr Val Val Thr Ala Ile Phe Gly Gly Ile Leu Gln Asn 
305                 310                 315                 320 


Glu Val Asn Cys Leu Ile Cys Gly Thr Glu Ser Arg Lys Phe Asp Pro 
                325                 330                 335     


Phe Leu Asp Leu Ser Leu Asp Ile Pro Ser Gln Phe Arg Ser Lys Arg 
            340                 345                 350         


Ser Lys Asn Gln Glu Asn Gly Pro Val Cys Ser Leu Arg Asp Cys Leu 
        355                 360                 365             


Arg Ser Phe Thr Asp Leu Glu Glu Leu Asp Glu Thr Glu Leu Tyr Met 
    370                 375                 380                 


Cys His Lys Cys Lys Lys Lys Gln Lys Ser Thr Lys Lys Phe Trp Ile 
385                 390                 395                 400 


Gln Lys Leu Pro Lys Val Leu Cys Leu His Leu Lys Arg Phe His Trp 
                405                 410                 415     


Thr Ala Tyr Leu Arg Asn Lys Val Asp Thr Tyr Val Glu Phe Pro Leu 
            420                 425                 430         


Arg Gly Leu Asp Met Lys Cys Tyr Leu Leu Glu Pro Glu Asn Ser Gly 
        435                 440                 445             


Pro Glu Ser Cys Leu Tyr Asp Leu Ala Ala Val Val Val His His Gly 
    450                 455                 460                 


Ser Gly Val Gly Ser Gly His Tyr Thr Ala Tyr Ala Thr His Glu Gly 
465                 470                 475                 480 


Arg Trp Phe His Phe Asn Asp Ser Thr Val Thr Leu Thr Asp Glu Glu 
                485                 490                 495     


Thr Val Val Lys Ala Lys Ala Tyr Ile Leu Phe Tyr Val Glu His Gln 
            500                 505                 510         


Ala Lys Ala Gly Ser Asp Lys Leu 
        515                 520 


<210> 389
<211> 1266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 389
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
    770                 775                 780                 


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
785                 790                 795                 800 


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
                805                 810                 815     


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
            820                 825                 830         


Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met 
        835                 840                 845             


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
    850                 855                 860                 


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
865                 870                 875                 880 


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
                885                 890                 895     


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
            900                 905                 910         


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
        915                 920                 925             


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
    930                 935                 940                 


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
945                 950                 955                 960 


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala 
                965                 970                 975     


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
            980                 985                 990         


Phe Val Thr Ala Ala Gly Ile Thr  Leu Gly Met Asp Glu  Leu Tyr Lys 
        995                 1000                 1005             


Gly Ser  Gly Ala Thr Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp 
    1010                 1015                 1020             


Val Glu  Glu Asn Pro Gly Pro  Met Val Ser Lys Gly  Glu Glu Asp 
    1025                 1030                 1035             


Asn Met  Ala Ile Ile Lys Glu  Phe Met Arg Phe Lys  Val His Met 
    1040                 1045                 1050             


Glu Gly  Ser Val Asn Gly His  Glu Phe Glu Ile Glu  Gly Glu Gly 
    1055                 1060                 1065             


Glu Gly  Arg Pro Tyr Glu Gly  Thr Gln Thr Ala Lys  Leu Lys Val 
    1070                 1075                 1080             


Thr Lys  Gly Gly Pro Leu Pro  Phe Ala Trp Asp Ile  Leu Ser Pro 
    1085                 1090                 1095             


Gln Phe  Met Tyr Gly Ser Lys  Ala Tyr Val Lys His  Pro Ala Asp 
    1100                 1105                 1110             


Ile Pro  Asp Tyr Leu Lys Leu  Ser Phe Pro Glu Gly  Phe Lys Trp 
    1115                 1120                 1125             


Glu Arg  Val Met Asn Phe Glu  Asp Gly Gly Val Val  Thr Val Thr 
    1130                 1135                 1140             


Gln Asp  Ser Ser Leu Gln Asp  Gly Glu Phe Ile Tyr  Lys Val Lys 
    1145                 1150                 1155             


Leu Arg  Gly Thr Asn Phe Pro  Ser Asp Gly Pro Val  Met Gln Lys 
    1160                 1165                 1170             


Lys Thr  Met Gly Trp Glu Ala  Ser Ser Glu Arg Met  Tyr Pro Glu 
    1175                 1180                 1185             


Asp Gly  Ala Leu Lys Gly Glu  Ile Lys Gln Arg Leu  Lys Leu Lys 
    1190                 1195                 1200             


Asp Gly  Gly His Tyr Asp Ala  Glu Val Lys Thr Thr  Tyr Lys Ala 
    1205                 1210                 1215             


Lys Lys  Pro Val Gln Leu Pro  Gly Ala Tyr Asn Val  Asn Ile Lys 
    1220                 1225                 1230             


Leu Asp  Ile Thr Ser His Asn  Glu Asp Tyr Thr Ile  Val Glu Gln 
    1235                 1240                 1245             


Tyr Glu  Arg Ala Glu Gly Arg  His Ser Thr Gly Gly  Met Asp Glu 
    1250                 1255                 1260             


Leu Tyr  Lys 
    1265     


<210> 390
<211> 1067
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 390
Met Ala Leu Pro Arg Pro Ser Glu Ala Val Pro Gln Asp Lys Val Cys 
1               5                   10                  15      


Tyr Pro Pro Glu Ser Ser Pro Gln Asn Leu Ala Ala Tyr Tyr Thr Pro 
            20                  25                  30          


Phe Pro Ser Tyr Gly His Tyr Arg Asn Ser Leu Ala Thr Val Glu Glu 
        35                  40                  45              


Asp Phe Gln Pro Phe Arg Gln Leu Glu Ala Ala Ala Ser Ala Ala Pro 
    50                  55                  60                  


Ala Met Pro Pro Phe Pro Phe Arg Met Ala Pro Pro Leu Leu Ser Pro 
65                  70                  75                  80  


Gly Leu Gly Leu Gln Arg Glu Pro Leu Tyr Asp Leu Pro Trp Tyr Ser 
                85                  90                  95      


Lys Leu Pro Pro Trp Tyr Pro Ile Pro His Val Pro Arg Glu Val Pro 
            100                 105                 110         


Pro Phe Leu Ser Ser Ser His Glu Tyr Ala Gly Ala Ser Ser Glu Asp 
        115                 120                 125             


Leu Gly His Gln Ile Ile Gly Gly Asp Asn Glu Ser Gly Pro Cys Cys 
    130                 135                 140                 


Gly Pro Asp Thr Leu Ile Pro Pro Pro Pro Ala Asp Ala Ser Leu Leu 
145                 150                 155                 160 


Pro Glu Gly Leu Arg Thr Ser Gln Leu Leu Pro Cys Ser Pro Ser Lys 
                165                 170                 175     


Gln Ser Glu Asp Gly Pro Lys Pro Ser Asn Gln Glu Gly Lys Ser Pro 
            180                 185                 190         


Ala Arg Phe Gln Phe Thr Glu Glu Asp Leu His Phe Val Leu Tyr Gly 
        195                 200                 205             


Val Thr Pro Ser Leu Glu His Pro Ala Ser Leu His His Ala Ile Ser 
    210                 215                 220                 


Gly Leu Leu Val Pro Pro Asp Ser Ser Gly Ser Asp Ser Leu Pro Gln 
225                 230                 235                 240 


Thr Leu Asp Lys Asp Ser Leu Gln Leu Pro Glu Gly Leu Cys Leu Met 
                245                 250                 255     


Gln Thr Val Phe Gly Glu Val Pro His Phe Gly Val Phe Cys Ser Ser 
            260                 265                 270         


Phe Ile Ala Lys Gly Val Arg Phe Gly Pro Phe Gln Gly Lys Val Val 
        275                 280                 285             


Asn Ala Ser Glu Val Lys Thr Tyr Gly Asp Asn Ser Val Met Trp Glu 
    290                 295                 300                 


Ile Phe Glu Asp Gly His Leu Ser His Phe Ile Asp Gly Lys Gly Gly 
305                 310                 315                 320 


Thr Gly Asn Trp Met Ser Tyr Val Asn Cys Ala Arg Phe Pro Lys Glu 
                325                 330                 335     


Gln Asn Leu Val Ala Val Gln Cys Gln Gly His Ile Phe Tyr Glu Ser 
            340                 345                 350         


Cys Lys Glu Ile His Gln Asn Gln Glu Leu Leu Val Trp Tyr Gly Asp 
        355                 360                 365             


Cys Tyr Glu Lys Phe Leu Asp Ile Pro Val Ser Leu Gln Val Thr Glu 
    370                 375                 380                 


Pro Gly Lys Gln Pro Ser Gly Pro Ser Glu Glu Ser Ala Glu Gly Tyr 
385                 390                 395                 400 


Arg Cys Glu Arg Cys Gly Lys Val Phe Thr Tyr Lys Tyr Tyr Arg Asp 
                405                 410                 415     


Lys His Leu Lys Tyr Thr Pro Cys Val Asp Lys Gly Asp Arg Lys Phe 
            420                 425                 430         


Pro Cys Ser Leu Cys Lys Arg Ser Phe Glu Lys Arg Asp Arg Leu Arg 
        435                 440                 445             


Ile His Ile Leu His Val His Glu Lys His Arg Pro His Lys Cys Ser 
    450                 455                 460                 


Thr Cys Gly Lys Cys Phe Ser Gln Ser Ser Ser Leu Asn Lys His Met 
465                 470                 475                 480 


Arg Val His Ser Gly Asp Arg Pro Tyr Gln Cys Val Tyr Cys Thr Lys 
                485                 490                 495     


Arg Phe Thr Ala Ser Ser Ile Leu Arg Thr His Ile Arg Gln His Ser 
            500                 505                 510         


Gly Glu Lys Pro Phe Lys Cys Lys Tyr Cys Gly Lys Ser Phe Ala Ser 
        515                 520                 525             


His Ala Ala His Asp Ser His Val Arg Arg Ser His Lys Glu Asp Asp 
    530                 535                 540                 


Gly Cys Ser Cys Ser Ile Cys Gly Lys Ile Phe Ser Asp Gln Glu Thr 
545                 550                 555                 560 


Phe Tyr Ser His Met Lys Phe His Glu Asp Tyr Val Ser Lys Gly Glu 
                565                 570                 575     


Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp 
            580                 585                 590         


Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala 
        595                 600                 605             


Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu 
    610                 615                 620                 


Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr Gly Leu Gln 
625                 630                 635                 640 


Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys 
                645                 650                 655     


Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys 
            660                 665                 670         


Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp 
        675                 680                 685             


Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp 
    690                 695                 700                 


Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn 
705                 710                 715                 720 


Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe 
                725                 730                 735     


Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His 
            740                 745                 750         


Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp 
        755                 760                 765             


Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu 
    770                 775                 780                 


Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile 
785                 790                 795                 800 


Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Ser Gly Ala Thr Asn Phe 
                805                 810                 815     


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
            820                 825                 830         


Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe Met 
        835                 840                 845             


Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe Glu 
    850                 855                 860                 


Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr Ala 
865                 870                 875                 880 


Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp Ile 
                885                 890                 895     


Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His Pro 
            900                 905                 910         


Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe Lys 
        915                 920                 925             


Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val Thr 
    930                 935                 940                 


Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys Leu 
945                 950                 955                 960 


Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys Thr 
                965                 970                 975     


Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly Ala 
            980                 985                 990         


Leu Lys Gly Glu Ile Lys Gln Arg  Leu Lys Leu Lys Asp  Gly Gly His 
        995                 1000                 1005             


Tyr Asp  Ala Glu Val Lys Thr  Thr Tyr Lys Ala Lys  Lys Pro Val 
    1010                 1015                 1020             


Gln Leu  Pro Gly Ala Tyr Asn  Val Asn Ile Lys Leu  Asp Ile Thr 
    1025                 1030                 1035             


Ser His  Asn Glu Asp Tyr Thr  Ile Val Glu Gln Tyr  Glu Arg Ala 
    1040                 1045                 1050             


Glu Gly  Arg His Ser Thr Gly  Gly Met Asp Glu Leu  Tyr Lys 
    1055                 1060                 1065         


<210> 391
<211> 830
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 391
Met Ala Thr Glu Glu Lys Lys Pro Glu Thr Glu Ala Ala Arg Ala Gln 
1               5                   10                  15      


Pro Thr Pro Ser Ser Ser Ala Thr Gln Ser Lys Pro Thr Pro Val Lys 
            20                  25                  30          


Pro Asn Tyr Ala Leu Lys Phe Thr Leu Ala Gly His Thr Lys Ala Val 
        35                  40                  45              


Ser Ser Val Lys Phe Ser Pro Asn Gly Glu Trp Leu Ala Ser Ser Ser 
    50                  55                  60                  


Ala Asp Lys Leu Ile Lys Ile Trp Gly Ala Tyr Asp Gly Lys Phe Glu 
65                  70                  75                  80  


Lys Thr Ile Ser Gly His Lys Leu Gly Ile Ser Asp Val Ala Trp Ser 
                85                  90                  95      


Ser Asp Ser Asn Leu Leu Val Ser Ala Ser Asp Asp Lys Thr Leu Lys 
            100                 105                 110         


Ile Trp Asp Val Ser Ser Gly Lys Cys Leu Lys Thr Leu Lys Gly His 
        115                 120                 125             


Ser Asn Tyr Val Phe Cys Cys Asn Phe Asn Pro Gln Ser Asn Leu Ile 
    130                 135                 140                 


Val Ser Gly Ser Phe Asp Glu Ser Val Arg Ile Trp Asp Val Lys Thr 
145                 150                 155                 160 


Gly Lys Cys Leu Lys Thr Leu Pro Ala His Ser Asp Pro Val Ser Ala 
                165                 170                 175     


Val His Phe Asn Arg Asp Gly Ser Leu Ile Val Ser Ser Ser Tyr Asp 
            180                 185                 190         


Gly Leu Cys Arg Ile Trp Asp Thr Ala Ser Gly Gln Cys Leu Lys Thr 
        195                 200                 205             


Leu Ile Asp Asp Asp Asn Pro Pro Val Ser Phe Val Lys Phe Ser Pro 
    210                 215                 220                 


Asn Gly Lys Tyr Ile Leu Ala Ala Thr Leu Asp Asn Thr Leu Lys Leu 
225                 230                 235                 240 


Trp Asp Tyr Ser Lys Gly Lys Cys Leu Lys Thr Tyr Thr Gly His Lys 
                245                 250                 255     


Asn Glu Lys Tyr Cys Ile Phe Ala Asn Phe Ser Val Thr Gly Gly Lys 
            260                 265                 270         


Trp Ile Val Ser Gly Ser Glu Asp Asn Leu Val Tyr Ile Trp Asn Leu 
        275                 280                 285             


Gln Thr Lys Glu Ile Val Gln Lys Leu Gln Gly His Thr Asp Val Val 
    290                 295                 300                 


Ile Ser Thr Ala Cys His Pro Thr Glu Asn Ile Ile Ala Ser Ala Ala 
305                 310                 315                 320 


Leu Glu Asn Asp Lys Thr Ile Lys Leu Trp Lys Ser Asp Cys Val Ser 
                325                 330                 335     


Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu 
            340                 345                 350         


Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu 
        355                 360                 365             


Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr 
    370                 375                 380                 


Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Gly Tyr 
385                 390                 395                 400 


Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met Lys Gln His Asp 
                405                 410                 415     


Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile 
            420                 425                 430         


Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe 
        435                 440                 445             


Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe 
    450                 455                 460                 


Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn 
465                 470                 475                 480 


Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys 
                485                 490                 495     


Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu 
            500                 505                 510         


Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu 
        515                 520                 525             


Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala Leu Ser Lys Asp 
    530                 535                 540                 


Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr Ala 
545                 550                 555                 560 


Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly Ser Gly Ala 
                565                 570                 575     


Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro 
            580                 585                 590         


Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys 
        595                 600                 605             


Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His 
    610                 615                 620                 


Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr 
625                 630                 635                 640 


Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala 
                645                 650                 655     


Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val 
            660                 665                 670         


Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu 
        675                 680                 685             


Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val 
    690                 695                 700                 


Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys 
705                 710                 715                 720 


Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln 
                725                 730                 735     


Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu 
            740                 745                 750         


Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp 
        755                 760                 765             


Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys 
    770                 775                 780                 


Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile 
785                 790                 795                 800 


Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala 
                805                 810                 815     


Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys 
            820                 825                 830 


<210> 392
<211> 930
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 392
Met Glu Val Arg Pro Lys Glu Ser Trp Asn His Ala Asp Phe Val His 
1               5                   10                  15      


Cys Glu Asp Thr Glu Ser Val Pro Gly Lys Pro Ser Val Asn Ala Asp 
            20                  25                  30          


Glu Glu Val Gly Gly Pro Gln Ile Cys Arg Val Cys Gly Asp Lys Ala 
        35                  40                  45              


Thr Gly Tyr His Phe Asn Val Met Thr Cys Glu Gly Cys Lys Gly Phe 
    50                  55                  60                  


Phe Arg Arg Ala Met Lys Arg Asn Ala Arg Leu Arg Cys Pro Phe Arg 
65                  70                  75                  80  


Lys Gly Ala Cys Glu Ile Thr Arg Lys Thr Arg Arg Gln Cys Gln Ala 
                85                  90                  95      


Cys Arg Leu Arg Lys Cys Leu Glu Ser Gly Met Lys Lys Glu Met Ile 
            100                 105                 110         


Met Ser Asp Glu Ala Val Glu Glu Arg Arg Ala Leu Ile Lys Arg Lys 
        115                 120                 125             


Lys Ser Glu Arg Thr Gly Thr Gln Pro Leu Gly Val Gln Gly Leu Thr 
    130                 135                 140                 


Glu Glu Gln Arg Met Met Ile Arg Glu Leu Met Asp Ala Gln Met Lys 
145                 150                 155                 160 


Thr Phe Asp Thr Thr Phe Ser His Phe Lys Asn Phe Arg Leu Pro Gly 
                165                 170                 175     


Val Leu Ser Ser Gly Cys Glu Leu Pro Glu Ser Leu Gln Ala Pro Ser 
            180                 185                 190         


Arg Glu Glu Ala Ala Lys Trp Ser Gln Val Arg Lys Asp Leu Cys Ser 
        195                 200                 205             


Leu Lys Val Ser Leu Gln Leu Arg Gly Glu Asp Gly Ser Val Trp Asn 
    210                 215                 220                 


Tyr Lys Pro Pro Ala Asp Ser Gly Gly Lys Glu Ile Phe Ser Leu Leu 
225                 230                 235                 240 


Pro His Met Ala Asp Met Ser Thr Tyr Met Phe Lys Gly Ile Ile Ser 
                245                 250                 255     


Phe Ala Lys Val Ile Ser Tyr Phe Arg Asp Leu Pro Ile Glu Asp Gln 
            260                 265                 270         


Ile Ser Leu Leu Lys Gly Ala Ala Phe Glu Leu Cys Gln Leu Arg Phe 
        275                 280                 285             


Asn Thr Val Phe Asn Ala Glu Thr Gly Thr Trp Glu Cys Gly Arg Leu 
    290                 295                 300                 


Ser Tyr Cys Leu Glu Asp Thr Ala Gly Gly Phe Gln Gln Leu Leu Leu 
305                 310                 315                 320 


Glu Pro Met Leu Lys Phe His Tyr Met Leu Lys Lys Leu Gln Leu His 
                325                 330                 335     


Glu Glu Glu Tyr Val Leu Met Gln Ala Ile Ser Leu Phe Ser Pro Asp 
            340                 345                 350         


Arg Pro Gly Val Leu Gln His Arg Val Val Asp Gln Leu Gln Glu Gln 
        355                 360                 365             


Phe Ala Ile Thr Leu Lys Ser Tyr Ile Glu Cys Asn Arg Pro Gln Pro 
    370                 375                 380                 


Ala His Arg Phe Leu Phe Leu Lys Ile Met Ala Met Leu Thr Glu Leu 
385                 390                 395                 400 


Arg Ser Ile Asn Ala Gln His Thr Gln Arg Leu Leu Arg Ile Gln Asp 
                405                 410                 415     


Ile His Pro Phe Ala Thr Pro Leu Met Gln Glu Leu Phe Gly Ile Thr 
            420                 425                 430         


Gly Ser Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile 
        435                 440                 445             


Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser 
    450                 455                 460                 


Gly Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe 
465                 470                 475                 480 


Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr 
                485                 490                 495     


Thr Phe Gly Tyr Gly Leu Gln Cys Phe Ala Arg Tyr Pro Asp His Met 
            500                 505                 510         


Lys Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln 
        515                 520                 525             


Glu Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala 
    530                 535                 540                 


Glu Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys 
545                 550                 555                 560 


Gly Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu 
                565                 570                 575     


Tyr Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys 
            580                 585                 590         


Asn Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly 
        595                 600                 605             


Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp 
    610                 615                 620                 


Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Tyr Gln Ser Ala 
625                 630                 635                 640 


Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu 
                645                 650                 655     


Phe Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
            660                 665                 670         


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
        675                 680                 685             


Glu Glu Asn Pro Gly Pro Met Val Ser Lys Gly Glu Glu Asp Asn Met 
    690                 695                 700                 


Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu Gly Ser 
705                 710                 715                 720 


Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro 
                725                 730                 735     


Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly Gly Pro 
            740                 745                 750         


Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser 
        755                 760                 765             


Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu 
    770                 775                 780                 


Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe Glu Asp 
785                 790                 795                 800 


Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu 
                805                 810                 815     


Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly 
            820                 825                 830         


Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser Glu Arg 
        835                 840                 845             


Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu 
    850                 855                 860                 


Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr Thr Tyr 
865                 870                 875                 880 


Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile 
                885                 890                 895     


Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val Glu Gln 
            900                 905                 910         


Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp Glu Leu 
        915                 920                 925             


Tyr Lys 
    930 


<210> 393
<211> 655
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 393
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser 
            260                 265                 270         


Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro 
        275                 280                 285             


Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu 
    290                 295                 300                 


Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg 
305                 310                 315                 320 


Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro 
                325                 330                 335     


Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr 
            340                 345                 350         


Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser 
        355                 360                 365             


Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser 
    370                 375                 380                 


Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp 
385                 390                 395                 400 


Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His 
                405                 410                 415     


Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys 
            420                 425                 430         


Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr 
        435                 440                 445             


Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln 
    450                 455                 460                 


Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met 
465                 470                 475                 480 


His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu 
                485                 490                 495     


Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala 
            500                 505                 510         


His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg 
        515                 520                 525             


Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr 
    530                 535                 540                 


Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val 
545                 550                 555                 560 


Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln 
                565                 570                 575     


Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu 
            580                 585                 590         


Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp 
        595                 600                 605             


Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile 
    610                 615                 620                 


Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val 
625                 630                 635                 640 


Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                645                 650                 655 


<210> 394
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 394
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val 
            260                 265                 270         


Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His 
        275                 280                 285             


Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val 
    290                 295                 300                 


Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His 
305                 310                 315                 320 


Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp 
                325                 330                 335     


Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly 
            340                 345                 350         


Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His 
        355                 360                 365             


Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile 
    370                 375                 380                 


His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser 
385                 390                 395                 400 


Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro 
                405                 410                 415     


Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys 
            420                 425                 430         


Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met 
        435                 440                 445             


Tyr Ile Glu Gln Asn Ala Cys Ser 
    450                 455     


<210> 395
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 395
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile 
            260                 265                 270         


Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val 
        275                 280                 285             


Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser 
    290                 295                 300                 


Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu 
305                 310                 315                 320 


Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala 
                325                 330                 335     


Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val 
            340                 345                 350         


Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu 
        355                 360                 365             


Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys 
    370                 375                 380                 


Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu 
385                 390                 395                 400 


Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe 
                405                 410                 415     


Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser 
            420                 425                 430         


Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg 
        435                 440                 445             


Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser 
    450                 455                 460                 


Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg 
465                 470                 475                 480 


Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr 
                485                 490                 495     


Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His 
            500                 505                 510         


Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu 
        515                 520                 525             


Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe 
    530                 535                 540                 


Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys 
545                 550                 555                 560 


Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln 
                565                 570                 575     


Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser 
            580                 585                 590         


Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala 
        595                 600                 605             


Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn 
    610                 615                 620                 


Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu 
625                 630                 635                 640 


Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn 
                645                 650                 655     


Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val 
            660                 665                 670         


Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg 
        675                 680                 685             


Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr 
    690                 695                 700                 


Arg Gln Ile Arg Pro Cys Thr Ser Leu Ser 
705                 710                 


<210> 396
<211> 631
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 396
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ser Asp Asp Lys Met Ala His His Thr Leu Leu 
            260                 265                 270         


Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe 
        275                 280                 285             


Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp 
    290                 295                 300                 


Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg 
305                 310                 315                 320 


Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp 
                325                 330                 335     


His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val 
            340                 345                 350         


Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala 
        355                 360                 365             


Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn 
    370                 375                 380                 


Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro 
385                 390                 395                 400 


Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser 
                405                 410                 415     


Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu 
            420                 425                 430         


Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu 
        435                 440                 445             


Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys 
    450                 455                 460                 


Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val 
465                 470                 475                 480 


Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu 
                485                 490                 495     


Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser 
            500                 505                 510         


Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His 
        515                 520                 525             


Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val 
    530                 535                 540                 


Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser 
545                 550                 555                 560 


Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His 
                565                 570                 575     


Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln 
            580                 585                 590         


Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu 
        595                 600                 605             


Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met 
    610                 615                 620                 


Gln Glu Pro Pro Arg Cys Leu 
625                 630     


<210> 397
<211> 436
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 397
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu 
            260                 265                 270         


Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg 
        275                 280                 285             


Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val 
    290                 295                 300                 


Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu 
305                 310                 315                 320 


Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn 
                325                 330                 335     


Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met 
            340                 345                 350         


Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser 
        355                 360                 365             


Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser 
    370                 375                 380                 


Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser 
385                 390                 395                 400 


Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val 
                405                 410                 415     


Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu 
            420                 425                 430         


Val Ala Asp Glu 
        435     


<210> 398
<211> 770
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 398
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Pro Pro Ser Phe Ser Glu Gly Ser 
    370                 375                 380                 


Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr 
385                 390                 395                 400 


Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu 
                405                 410                 415     


Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser 
            420                 425                 430         


Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn 
        435                 440                 445             


Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu 
    450                 455                 460                 


Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
465                 470                 475                 480 


Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
                485                 490                 495     


Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr 
            500                 505                 510         


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
        515                 520                 525             


Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu 
    530                 535                 540                 


Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp 
545                 550                 555                 560 


Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp 
                565                 570                 575     


Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu 
            580                 585                 590         


Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu 
        595                 600                 605             


Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe 
    610                 615                 620                 


Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr 
625                 630                 635                 640 


Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly 
                645                 650                 655     


Gly Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser 
            660                 665                 670         


Pro Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser 
        675                 680                 685             


Met Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr 
    690                 695                 700                 


Asp Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly 
705                 710                 715                 720 


Lys Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala 
                725                 730                 735     


Ser Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr 
            740                 745                 750         


Met Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu 
        755                 760                 765             


Ala Gln 
    770 


<210> 399
<211> 571
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 399
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Asp Glu Lys Leu Ala Leu Tyr Leu 
    370                 375                 380                 


Ala Glu Val Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr 
385                 390                 395                 400 


Arg Phe His Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser 
                405                 410                 415     


Lys Thr Val Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln 
            420                 425                 430         


Thr Val His Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile 
        435                 440                 445             


Glu Gly Asp Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala 
    450                 455                 460                 


Trp Ala Gly Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val 
465                 470                 475                 480 


Asn Ile His Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser 
                485                 490                 495     


Thr Met Ile His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile 
            500                 505                 510         


Trp Leu Ser Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His 
        515                 520                 525             


Ser Tyr Pro Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val 
    530                 535                 540                 


Gln Arg Lys Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu 
545                 550                 555                 560 


Ser Lys Met Tyr Ile Glu Gln Asn Ala Cys Ser 
                565                 570     


<210> 400
<211> 828
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 400
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Leu Glu Val Asp Phe Lys Lys Leu 
    370                 375                 380                 


Lys Gln Ile Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn 
385                 390                 395                 400 


Ala Cys Val Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr 
                405                 410                 415     


Lys Ser Ser Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val 
            420                 425                 430         


Arg Leu Leu Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val 
        435                 440                 445             


His Leu Ala Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu 
    450                 455                 460                 


Thr Glu Val Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys 
465                 470                 475                 480 


Pro Glu Leu Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His 
                485                 490                 495     


Gln Arg Lys Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr 
            500                 505                 510         


Phe Thr Leu Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu 
        515                 520                 525             


Lys Leu Phe Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu 
    530                 535                 540                 


Glu Glu Ser Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu 
545                 550                 555                 560 


Asp Ser Arg Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu 
                565                 570                 575     


Leu Asp Ser Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser 
            580                 585                 590         


Val Leu Arg Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp 
        595                 600                 605             


Phe Tyr Thr Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe 
    610                 615                 620                 


Gly Leu His Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala 
625                 630                 635                 640 


Phe Ile Leu Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr 
                645                 650                 655     


His Ile Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr 
            660                 665                 670         


Gly Val Lys Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr 
        675                 680                 685             


Arg Phe Gln Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys 
    690                 695                 700                 


Trp Lys Ser Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala 
705                 710                 715                 720 


Leu Val Ala Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala 
                725                 730                 735     


Asn Leu Asn Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val 
            740                 745                 750         


Asp Ser Glu Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu 
        755                 760                 765             


Leu Gly Asn Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp 
    770                 775                 780                 


Cys Cys Val Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser 
785                 790                 795                 800 


Arg Arg Arg Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu 
                805                 810                 815     


Asp Arg Tyr Arg Gln Ile Arg Pro Cys Thr Ser Leu 
            820                 825             


<210> 401
<211> 746
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 401
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Ser Asp Asp Lys Met Ala His His 
    370                 375                 380                 


Thr Leu Leu Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn 
385                 390                 395                 400 


Thr Cys Phe Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro 
                405                 410                 415     


Leu Arg Asp Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly 
            420                 425                 430         


Gly Gly Arg Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly 
        435                 440                 445             


Ala Leu Trp His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe 
    450                 455                 460                 


Arg Ala Val Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln 
465                 470                 475                 480 


Gln Asp Ala Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu 
                485                 490                 495     


Glu Ile Asn Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly 
            500                 505                 510         


Pro Val Pro Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro 
        515                 520                 525             


Glu Leu Ser Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu 
    530                 535                 540                 


Glu Arg Glu Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys 
545                 550                 555                 560 


Ser Cys Leu Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu 
                565                 570                 575     


Val Phe Cys Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly 
            580                 585                 590         


Gly Lys Val Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu 
        595                 600                 605             


Glu Leu Glu Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys 
    610                 615                 620                 


Thr Arg Ser Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu 
625                 630                 635                 640 


Val Leu His Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys 
                645                 650                 655     


Ser Ser Val Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp 
            660                 665                 670         


Phe Ala Ser Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu 
        675                 680                 685             


Cys Asn His Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys 
    690                 695                 700                 


Arg Cys Gln Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro 
705                 710                 715                 720 


Val Ser Glu Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr 
                725                 730                 735     


Gln Leu Met Gln Glu Pro Pro Arg Cys Leu 
            740                 745     


<210> 402
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 402
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gln Val Gln Leu Val Glu Ser Gly Gly Ala Leu 
            260                 265                 270         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        275                 280                 285             


Pro Val Asn Arg Tyr Ser Met Arg Trp Tyr Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Trp Val Ala Gly Met Ser Ser Ala Gly Asp Arg Ser Ser 
305                 310                 315                 320 


Tyr Glu Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala 
                325                 330                 335     


Arg Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Asn Val Asn Val Gly Phe Glu Tyr Trp Gly Gln 
        355                 360                 365             


Gly Thr Gln Val Thr Val Ser Ser Ala Thr Pro Met Asp Ala Tyr Leu 
    370                 375                 380                 


Arg Lys Leu Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys 
385                 390                 395                 400 


Leu Phe Arg Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His 
                405                 410                 415     


Val Glu Val Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu 
            420                 425                 430         


Lys Phe Glu Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg 
        435                 440                 445             


Leu Glu Asn Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu 
    450                 455                 460                 


Ser Leu Met Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val 
465                 470                 475                 480 


Ser Pro Ser Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu 
                485                 490                 495     


Cys Phe Ser Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr 
            500                 505                 510         


Lys Glu Ser Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr 
        515                 520                 525             


Glu Lys Val Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp 
    530                 535                 540                 


Thr Leu Glu Val Ala Asp Glu 
545                 550     


<210> 403
<211> 750
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 403
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Phe Tyr His Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Val Ser Tyr Pro Glu Tyr Tyr Phe Pro Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
        355                 360                 365             


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
    370                 375                 380                 


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
385                 390                 395                 400 


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
                405                 410                 415     


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
            420                 425                 430         


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
        435                 440                 445             


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
    450                 455                 460                 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
465                 470                 475                 480 


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
                485                 490                 495     


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
            500                 505                 510         


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
        515                 520                 525             


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
    530                 535                 540                 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
545                 550                 555                 560 


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
                565                 570                 575     


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
            580                 585                 590         


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
        595                 600                 605             


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
    610                 615                 620                 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
625                 630                 635                 640 


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
                645                 650                 655     


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys 
            660                 665                 670         


Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr 
        675                 680                 685             


Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu 
    690                 695                 700                 


Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu 
705                 710                 715                 720 


Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys 
                725                 730                 735     


Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            740                 745                 750 


<210> 404
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 404
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Phe Tyr His Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Val Ser Tyr Pro Glu Tyr Tyr Phe Pro Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu 
        355                 360                 365             


Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile 
    370                 375                 380                 


Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr 
385                 390                 395                 400 


Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr 
                405                 410                 415     


Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val 
            420                 425                 430         


Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr 
        435                 440                 445             


Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu 
    450                 455                 460                 


Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His 
465                 470                 475                 480 


Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp 
                485                 490                 495     


Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro Asn 
            500                 505                 510         


Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys Arg 
        515                 520                 525             


Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met Tyr 
    530                 535                 540                 


Ile Glu Gln Asn Ala Cys Ser 
545                 550     


<210> 405
<211> 809
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 405
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Phe Tyr His Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Val Ser Tyr Pro Glu Tyr Tyr Phe Pro Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
        355                 360                 365             


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
    370                 375                 380                 


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
385                 390                 395                 400 


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
                405                 410                 415     


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
            420                 425                 430         


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
        435                 440                 445             


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
    450                 455                 460                 


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
465                 470                 475                 480 


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
                485                 490                 495     


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
            500                 505                 510         


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
        515                 520                 525             


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
    530                 535                 540                 


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
545                 550                 555                 560 


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
                565                 570                 575     


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
            580                 585                 590         


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
        595                 600                 605             


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
    610                 615                 620                 


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
625                 630                 635                 640 


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
                645                 650                 655     


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
            660                 665                 670         


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
        675                 680                 685             


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met 
    690                 695                 700                 


Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr 
705                 710                 715                 720 


Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg 
                725                 730                 735     


Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu 
            740                 745                 750         


Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr 
        755                 760                 765             


Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn 
    770                 775                 780                 


His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg 
785                 790                 795                 800 


Gln Ile Arg Pro Cys Thr Ser Leu Ser 
                805                 


<210> 406
<211> 726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 406
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Phe Tyr His Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Val Ser Tyr Pro Glu Tyr Tyr Phe Pro Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu 
        355                 360                 365             


Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu 
    370                 375                 380                 


Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe 
385                 390                 395                 400 


Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala 
                405                 410                 415     


Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His 
            420                 425                 430         


Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe 
        435                 440                 445             


Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln 
    450                 455                 460                 


Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg 
465                 470                 475                 480 


Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser 
                485                 490                 495     


Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp 
            500                 505                 510         


Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp 
        515                 520                 525             


Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys 
    530                 535                 540                 


Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp 
545                 550                 555                 560 


Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser 
                565                 570                 575     


Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser 
            580                 585                 590         


Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr 
        595                 600                 605             


Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu 
    610                 615                 620                 


Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly 
625                 630                 635                 640 


Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp 
                645                 650                 655     


Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser 
            660                 665                 670         


Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr 
        675                 680                 685             


Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn 
    690                 695                 700                 


Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln 
705                 710                 715                 720 


Glu Pro Pro Arg Cys Leu 
                725     


<210> 407
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 407
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Phe Tyr His Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Val Ser Tyr Pro Glu Tyr Tyr Phe Pro Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu Gly 
        355                 360                 365             


Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg Ala 
    370                 375                 380                 


Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val Arg 
385                 390                 395                 400 


Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala 
                405                 410                 415     


Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro 
            420                 425                 430         


Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr 
        435                 440                 445             


Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln 
    450                 455                 460                 


Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn 
465                 470                 475                 480 


Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser 
                485                 490                 495     


Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe 
            500                 505                 510         


Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val 
        515                 520                 525             


Ala Asp Glu 
    530     


<210> 408
<211> 750
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 408
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Leu Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Gln Tyr Tyr Tyr Arg Gly Trp Tyr Val Gly Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg 
        355                 360                 365             


Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg 
    370                 375                 380                 


Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser 
385                 390                 395                 400 


Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser 
                405                 410                 415     


His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu 
            420                 425                 430         


Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn 
        435                 440                 445             


Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met 
    450                 455                 460                 


Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val 
465                 470                 475                 480 


Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly 
                485                 490                 495     


Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp 
            500                 505                 510         


Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly 
        515                 520                 525             


Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln 
    530                 535                 540                 


Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys 
545                 550                 555                 560 


Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His 
                565                 570                 575     


Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu 
            580                 585                 590         


Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His 
        595                 600                 605             


Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp 
    610                 615                 620                 


Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu 
625                 630                 635                 640 


Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu 
                645                 650                 655     


Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys 
            660                 665                 670         


Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr 
        675                 680                 685             


Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu 
    690                 695                 700                 


Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu 
705                 710                 715                 720 


Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys 
                725                 730                 735     


Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
            740                 745                 750 


<210> 409
<211> 551
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 409
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Leu Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Gln Tyr Tyr Tyr Arg Gly Trp Tyr Val Gly Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu Val Glu 
        355                 360                 365             


Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe His Ile 
    370                 375                 380                 


Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr Val Tyr 
385                 390                 395                 400 


Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val His Tyr 
                405                 410                 415     


Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly Asp Val 
            420                 425                 430         


Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala Gly Tyr 
        435                 440                 445             


Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile His Leu 
    450                 455                 460                 


Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met Ile His 
465                 470                 475                 480 


Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu Ser Trp 
                485                 490                 495     


Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr Pro Asn 
            500                 505                 510         


Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg Lys Arg 
        515                 520                 525             


Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys Met Tyr 
    530                 535                 540                 


Ile Glu Gln Asn Ala Cys Ser 
545                 550     


<210> 410
<211> 809
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 410
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Leu Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Gln Tyr Tyr Tyr Arg Gly Trp Tyr Val Gly Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Leu Glu Val Asp Phe Lys Lys Leu Lys Gln Ile Lys 
        355                 360                 365             


Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys Val Gly 
    370                 375                 380                 


Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser Ser Gly 
385                 390                 395                 400 


Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu Leu Asn 
                405                 410                 415     


Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu Ala Ile 
            420                 425                 430         


Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu Val Ser 
        435                 440                 445             


Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu Leu Thr 
    450                 455                 460                 


Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg Lys Gly 
465                 470                 475                 480 


Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr Leu Pro 
                485                 490                 495     


Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu Phe Asp 
            500                 505                 510         


Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu Ser Pro 
        515                 520                 525             


Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser Arg Leu 
    530                 535                 540                 


Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp Ser Val 
545                 550                 555                 560 


Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu Arg Lys 
                565                 570                 575     


Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr Thr Arg 
            580                 585                 590         


Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu His Phe 
        595                 600                 605             


Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile Leu Ser 
    610                 615                 620                 


Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile Phe Val 
625                 630                 635                 640 


Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val Lys Tyr 
                645                 650                 655     


Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe Gln Gly 
            660                 665                 670         


Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys Ser Pro 
        675                 680                 685             


Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val Ala Met 
    690                 695                 700                 


Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu Asn Thr 
705                 710                 715                 720 


Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser Glu Arg 
                725                 730                 735     


Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly Asn Glu 
            740                 745                 750         


Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys Val Thr 
        755                 760                 765             


Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg Arg Asn 
    770                 775                 780                 


His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg Tyr Arg 
785                 790                 795                 800 


Gln Ile Arg Pro Cys Thr Ser Leu Ser 
                805                 


<210> 411
<211> 726
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 411
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Leu Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Gln Tyr Tyr Tyr Arg Gly Trp Tyr Val Gly Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Ser Asp Asp Lys Met Ala His His Thr Leu Leu Leu 
        355                 360                 365             


Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys Phe Leu 
    370                 375                 380                 


Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg Asp Phe 
385                 390                 395                 400 


Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly Arg Ala 
                405                 410                 415     


Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu Trp His 
            420                 425                 430         


Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala Val Phe 
        435                 440                 445             


Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp Ala Gln 
    450                 455                 460                 


Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile Asn Arg 
465                 470                 475                 480 


Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val Pro Ser 
                485                 490                 495     


Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu Ser Asp 
            500                 505                 510         


Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg Glu Asp 
        515                 520                 525             


Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys Leu Lys 
    530                 535                 540                 


Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe Cys Asp 
545                 550                 555                 560 


Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys Val Ser 
                565                 570                 575     


Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu Glu Ser 
            580                 585                 590         


Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg Ser Thr 
        595                 600                 605             


Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu His Leu 
    610                 615                 620                 


Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser Val Gly 
625                 630                 635                 640 


Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala Ser Asp 
                645                 650                 655     


Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn His Ser 
            660                 665                 670         


Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys Gln Thr 
        675                 680                 685             


Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser Glu Asn 
    690                 695                 700                 


Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu Met Gln 
705                 710                 715                 720 


Glu Pro Pro Arg Cys Leu 
                725     


<210> 412
<211> 531
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 412
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Asp Leu Tyr Phe Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Thr Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Gln Tyr Tyr Tyr Arg Gly Trp Tyr Val Gly Ser Pro Ile Ser Ile 
            340                 345                 350         


Asn Tyr Arg Thr Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys Leu Gly 
        355                 360                 365             


Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe Arg Ala 
    370                 375                 380                 


Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu Val Arg 
385                 390                 395                 400 


Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe Glu Ala 
                405                 410                 415     


Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu Asn Pro 
            420                 425                 430         


Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu Met Tyr 
        435                 440                 445             


Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro Ser Gln 
    450                 455                 460                 


Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe Ser Asn 
465                 470                 475                 480 


Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu Ser Ser 
                485                 490                 495     


Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys Val Phe 
            500                 505                 510         


Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu Glu Val 
        515                 520                 525             


Ala Asp Glu 
    530     


<210> 413
<211> 768
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 413
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ala Ser Thr Ser Gly Ser Thr His Tyr Tyr Lys 
            260                 265                 270         


Gln Thr Ala Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
        275                 280                 285             


Ile Ser Trp Pro Pro Pro Tyr Tyr Val Glu Gly Val Thr Val Phe Arg 
    290                 295                 300                 


Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr 
305                 310                 315                 320 


Val Pro Tyr Trp Thr Glu Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
                325                 330                 335     


Val Asp Tyr Thr Ile Thr Val Tyr Ala Glu Met Tyr Pro Gly Ser Pro 
            340                 345                 350         


Trp Ala Gly Gln Val Met Asp Ile Gln Pro Ile Ser Ile Asn Tyr Arg 
        355                 360                 365             


Thr Glu Gly Ser Gly Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
    370                 375                 380                 


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
385                 390                 395                 400 


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
                405                 410                 415     


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
            420                 425                 430         


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
        435                 440                 445             


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
    450                 455                 460                 


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
465                 470                 475                 480 


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
                485                 490                 495     


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
            500                 505                 510         


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
        515                 520                 525             


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
    530                 535                 540                 


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
545                 550                 555                 560 


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
                565                 570                 575     


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
            580                 585                 590         


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
        595                 600                 605             


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
    610                 615                 620                 


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
625                 630                 635                 640 


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
                645                 650                 655     


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
            660                 665                 670         


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
        675                 680                 685             


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
    690                 695                 700                 


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
705                 710                 715                 720 


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
                725                 730                 735     


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
            740                 745                 750         


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
        755                 760                 765             


<210> 414
<211> 569
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 414
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ala Ser Thr Ser Gly Ser Thr His Tyr Tyr Lys 
            260                 265                 270         


Gln Thr Ala Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
        275                 280                 285             


Ile Ser Trp Pro Pro Pro Tyr Tyr Val Glu Gly Val Thr Val Phe Arg 
    290                 295                 300                 


Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr 
305                 310                 315                 320 


Val Pro Tyr Trp Thr Glu Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
                325                 330                 335     


Val Asp Tyr Thr Ile Thr Val Tyr Ala Glu Met Tyr Pro Gly Ser Pro 
            340                 345                 350         


Trp Ala Gly Gln Val Met Asp Ile Gln Pro Ile Ser Ile Asn Tyr Arg 
        355                 360                 365             


Thr Glu Gly Ser Gly Ser Asp Glu Lys Leu Ala Leu Tyr Leu Ala Glu 
    370                 375                 380                 


Val Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg Phe 
385                 390                 395                 400 


His Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys Thr 
                405                 410                 415     


Val Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr Val 
            420                 425                 430         


His Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu Gly 
        435                 440                 445             


Asp Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp Ala 
    450                 455                 460                 


Gly Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn Ile 
465                 470                 475                 480 


His Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr Met 
                485                 490                 495     


Ile His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp Leu 
            500                 505                 510         


Ser Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser Tyr 
        515                 520                 525             


Pro Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln Arg 
    530                 535                 540                 


Lys Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser Lys 
545                 550                 555                 560 


Met Tyr Ile Glu Gln Asn Ala Cys Ser 
                565                 


<210> 415
<211> 827
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 415
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ala Ser Thr Ser Gly Ser Thr His Tyr Tyr Lys 
            260                 265                 270         


Gln Thr Ala Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
        275                 280                 285             


Ile Ser Trp Pro Pro Pro Tyr Tyr Val Glu Gly Val Thr Val Phe Arg 
    290                 295                 300                 


Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr 
305                 310                 315                 320 


Val Pro Tyr Trp Thr Glu Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
                325                 330                 335     


Val Asp Tyr Thr Ile Thr Val Tyr Ala Glu Met Tyr Pro Gly Ser Pro 
            340                 345                 350         


Trp Ala Gly Gln Val Met Asp Ile Gln Pro Ile Ser Ile Asn Tyr Arg 
        355                 360                 365             


Thr Glu Gly Ser Gly Ser Leu Glu Val Asp Phe Lys Lys Leu Lys Gln 
    370                 375                 380                 


Ile Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala Cys 
385                 390                 395                 400 


Val Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys Ser 
                405                 410                 415     


Ser Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg Leu 
            420                 425                 430         


Leu Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His Leu 
        435                 440                 445             


Ala Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr Glu 
    450                 455                 460                 


Val Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro Glu 
465                 470                 475                 480 


Leu Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln Arg 
                485                 490                 495     


Lys Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe Thr 
            500                 505                 510         


Leu Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys Leu 
        515                 520                 525             


Phe Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu Glu 
    530                 535                 540                 


Ser Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp Ser 
545                 550                 555                 560 


Arg Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu Asp 
                565                 570                 575     


Ser Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val Leu 
            580                 585                 590         


Arg Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe Tyr 
        595                 600                 605             


Thr Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly Leu 
    610                 615                 620                 


His Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe Ile 
625                 630                 635                 640 


Leu Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His Ile 
                645                 650                 655     


Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly Val 
            660                 665                 670         


Lys Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg Phe 
        675                 680                 685             


Gln Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp Lys 
    690                 695                 700                 


Ser Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu Val 
705                 710                 715                 720 


Ala Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn Leu 
                725                 730                 735     


Asn Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp Ser 
            740                 745                 750         


Glu Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu Gly 
        755                 760                 765             


Asn Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys Cys 
    770                 775                 780                 


Val Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg Arg 
785                 790                 795                 800 


Arg Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp Arg 
                805                 810                 815     


Tyr Arg Gln Ile Arg Pro Cys Thr Ser Leu Ser 
            820                 825         


<210> 416
<211> 744
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 416
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ala Ser Thr Ser Gly Ser Thr His Tyr Tyr Lys 
            260                 265                 270         


Gln Thr Ala Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
        275                 280                 285             


Ile Ser Trp Pro Pro Pro Tyr Tyr Val Glu Gly Val Thr Val Phe Arg 
    290                 295                 300                 


Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr 
305                 310                 315                 320 


Val Pro Tyr Trp Thr Glu Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
                325                 330                 335     


Val Asp Tyr Thr Ile Thr Val Tyr Ala Glu Met Tyr Pro Gly Ser Pro 
            340                 345                 350         


Trp Ala Gly Gln Val Met Asp Ile Gln Pro Ile Ser Ile Asn Tyr Arg 
        355                 360                 365             


Thr Glu Gly Ser Gly Ser Ser Asp Asp Lys Met Ala His His Thr Leu 
    370                 375                 380                 


Leu Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr Cys 
385                 390                 395                 400 


Phe Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu Arg 
                405                 410                 415     


Asp Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly Gly 
            420                 425                 430         


Arg Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala Leu 
        435                 440                 445             


Trp His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg Ala 
    450                 455                 460                 


Val Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln Asp 
465                 470                 475                 480 


Ala Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu Ile 
                485                 490                 495     


Asn Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro Val 
            500                 505                 510         


Pro Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu Leu 
        515                 520                 525             


Ser Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu Arg 
    530                 535                 540                 


Glu Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser Cys 
545                 550                 555                 560 


Leu Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val Phe 
                565                 570                 575     


Cys Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly Lys 
            580                 585                 590         


Val Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu Leu 
        595                 600                 605             


Glu Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr Arg 
    610                 615                 620                 


Ser Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val Leu 
625                 630                 635                 640 


His Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser Ser 
                645                 650                 655     


Val Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe Ala 
            660                 665                 670         


Ser Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys Asn 
        675                 680                 685             


His Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg Cys 
    690                 695                 700                 


Gln Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val Ser 
705                 710                 715                 720 


Glu Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln Leu 
                725                 730                 735     


Met Gln Glu Pro Pro Arg Cys Leu 
            740                 


<210> 417
<211> 549
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 417
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Ala Ser Thr Ser Gly Ser Thr His Tyr Tyr Lys 
            260                 265                 270         


Gln Thr Ala Asp Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu 
        275                 280                 285             


Ile Ser Trp Pro Pro Pro Tyr Tyr Val Glu Gly Val Thr Val Phe Arg 
    290                 295                 300                 


Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr 
305                 310                 315                 320 


Val Pro Tyr Trp Thr Glu Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly 
                325                 330                 335     


Val Asp Tyr Thr Ile Thr Val Tyr Ala Glu Met Tyr Pro Gly Ser Pro 
            340                 345                 350         


Trp Ala Gly Gln Val Met Asp Ile Gln Pro Ile Ser Ile Asn Tyr Arg 
        355                 360                 365             


Thr Glu Gly Ser Gly Ser Ala Thr Pro Met Asp Ala Tyr Leu Arg Lys 
    370                 375                 380                 


Leu Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu Phe 
385                 390                 395                 400 


Arg Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val Glu 
                405                 410                 415     


Val Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys Phe 
            420                 425                 430         


Glu Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu Glu 
        435                 440                 445             


Asn Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser Leu 
    450                 455                 460                 


Met Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser Pro 
465                 470                 475                 480 


Ser Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys Phe 
                485                 490                 495     


Ser Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys Glu 
            500                 505                 510         


Ser Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu Lys 
        515                 520                 525             


Val Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr Leu 
    530                 535                 540                 


Glu Val Ala Asp Glu 
545                 


<210> 418
<211> 753
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 418
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Lys Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Gln Gly Gly Gly Arg Trp His Pro Tyr Gly Tyr Tyr Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Pro Pro Ser Phe Ser Glu Gly Ser Gly 
        355                 360                 365             


Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg 
    370                 375                 380                 


Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys 
385                 390                 395                 400 


Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu 
                405                 410                 415     


Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu 
            420                 425                 430         


His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr 
        435                 440                 445             


Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu 
    450                 455                 460                 


Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp 
465                 470                 475                 480 


Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr 
                485                 490                 495     


Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly 
            500                 505                 510         


Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met 
        515                 520                 525             


Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln 
    530                 535                 540                 


Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu 
545                 550                 555                 560 


Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro 
                565                 570                 575     


Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser 
            580                 585                 590         


Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val 
        595                 600                 605             


Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met 
    610                 615                 620                 


Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly 
625                 630                 635                 640 


Ile Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro 
                645                 650                 655     


Leu Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met 
            660                 665                 670         


Glu Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp 
        675                 680                 685             


Ser Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys 
    690                 695                 700                 


Gly Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser 
705                 710                 715                 720 


Val Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met 
                725                 730                 735     


Asn Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala 
            740                 745                 750         


Gln 
    


<210> 419
<211> 554
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 419
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Lys Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Gln Gly Gly Gly Arg Trp His Pro Tyr Gly Tyr Tyr Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Asp Glu Lys Leu Ala Leu Tyr Leu Ala 
        355                 360                 365             


Glu Val Glu Lys Gln Asp Lys Tyr Leu Arg Gln Arg Asn Lys Tyr Arg 
    370                 375                 380                 


Phe His Ile Ile Pro Asp Gly Asn Cys Leu Tyr Arg Ala Val Ser Lys 
385                 390                 395                 400 


Thr Val Tyr Gly Asp Gln Ser Leu His Arg Glu Leu Arg Glu Gln Thr 
                405                 410                 415     


Val His Tyr Ile Ala Asp His Leu Asp His Phe Ser Pro Leu Ile Glu 
            420                 425                 430         


Gly Asp Val Gly Glu Phe Ile Ile Ala Ala Ala Gln Asp Gly Ala Trp 
        435                 440                 445             


Ala Gly Tyr Pro Glu Leu Leu Ala Met Gly Gln Met Leu Asn Val Asn 
    450                 455                 460                 


Ile His Leu Thr Thr Gly Gly Arg Leu Glu Ser Pro Thr Val Ser Thr 
465                 470                 475                 480 


Met Ile His Tyr Leu Gly Pro Glu Asp Ser Leu Arg Pro Ser Ile Trp 
                485                 490                 495     


Leu Ser Trp Leu Ser Asn Gly His Tyr Asp Ala Val Phe Asp His Ser 
            500                 505                 510         


Tyr Pro Asn Pro Glu Tyr Asp Asn Trp Cys Lys Gln Thr Gln Val Gln 
        515                 520                 525             


Arg Lys Arg Asp Glu Glu Leu Ala Lys Ser Met Ala Ile Ser Leu Ser 
    530                 535                 540                 


Lys Met Tyr Ile Glu Gln Asn Ala Cys Ser 
545                 550                 


<210> 420
<211> 812
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 420
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Lys Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Gln Gly Gly Gly Arg Trp His Pro Tyr Gly Tyr Tyr Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Leu Glu Val Asp Phe Lys Lys Leu Lys 
        355                 360                 365             


Gln Ile Lys Asn Arg Met Lys Lys Thr Asp Trp Leu Phe Leu Asn Ala 
    370                 375                 380                 


Cys Val Gly Val Val Glu Gly Asp Leu Ala Ala Ile Glu Ala Tyr Lys 
385                 390                 395                 400 


Ser Ser Gly Gly Asp Ile Ala Arg Gln Leu Thr Ala Asp Glu Val Arg 
                405                 410                 415     


Leu Leu Asn Arg Pro Ser Ala Phe Asp Val Gly Tyr Thr Leu Val His 
            420                 425                 430         


Leu Ala Ile Arg Phe Gln Arg Gln Asp Met Leu Ala Ile Leu Leu Thr 
        435                 440                 445             


Glu Val Ser Gln Gln Ala Ala Lys Cys Ile Pro Ala Met Val Cys Pro 
    450                 455                 460                 


Glu Leu Thr Glu Gln Ile Arg Arg Glu Ile Ala Ala Ser Leu His Gln 
465                 470                 475                 480 


Arg Lys Gly Asp Phe Ala Cys Tyr Phe Leu Thr Asp Leu Val Thr Phe 
                485                 490                 495     


Thr Leu Pro Ala Asp Ile Glu Asp Leu Pro Pro Thr Val Gln Glu Lys 
            500                 505                 510         


Leu Phe Asp Glu Val Leu Asp Arg Asp Val Gln Lys Glu Leu Glu Glu 
        515                 520                 525             


Glu Ser Pro Ile Ile Asn Trp Ser Leu Glu Leu Ala Thr Arg Leu Asp 
    530                 535                 540                 


Ser Arg Leu Tyr Ala Leu Trp Asn Arg Thr Ala Gly Asp Cys Leu Leu 
545                 550                 555                 560 


Asp Ser Val Leu Gln Ala Thr Trp Gly Ile Tyr Asp Lys Asp Ser Val 
                565                 570                 575     


Leu Arg Lys Ala Leu His Asp Ser Leu His Asp Cys Ser His Trp Phe 
            580                 585                 590         


Tyr Thr Arg Trp Lys Asp Trp Glu Ser Trp Tyr Ser Gln Ser Phe Gly 
        595                 600                 605             


Leu His Phe Ser Leu Arg Glu Glu Gln Trp Gln Glu Asp Trp Ala Phe 
    610                 615                 620                 


Ile Leu Ser Leu Ala Ser Gln Pro Gly Ala Ser Leu Glu Gln Thr His 
625                 630                 635                 640 


Ile Phe Val Leu Ala His Ile Leu Arg Arg Pro Ile Ile Val Tyr Gly 
                645                 650                 655     


Val Lys Tyr Tyr Lys Ser Phe Arg Gly Glu Thr Leu Gly Tyr Thr Arg 
            660                 665                 670         


Phe Gln Gly Val Tyr Leu Pro Leu Leu Trp Glu Gln Ser Phe Cys Trp 
        675                 680                 685             


Lys Ser Pro Ile Ala Leu Gly Tyr Thr Arg Gly His Phe Ser Ala Leu 
    690                 695                 700                 


Val Ala Met Glu Asn Asp Gly Tyr Gly Asn Arg Gly Ala Gly Ala Asn 
705                 710                 715                 720 


Leu Asn Thr Asp Asp Asp Val Thr Ile Thr Phe Leu Pro Leu Val Asp 
                725                 730                 735     


Ser Glu Arg Lys Leu Leu His Val His Phe Leu Ser Ala Gln Glu Leu 
            740                 745                 750         


Gly Asn Glu Glu Gln Gln Glu Lys Leu Leu Arg Glu Trp Leu Asp Cys 
        755                 760                 765             


Cys Val Thr Glu Gly Gly Val Leu Val Ala Met Gln Lys Ser Ser Arg 
    770                 775                 780                 


Arg Arg Asn His Pro Leu Val Thr Gln Met Val Glu Lys Trp Leu Asp 
785                 790                 795                 800 


Arg Tyr Arg Gln Ile Arg Pro Cys Thr Ser Leu Ser 
                805                 810         


<210> 421
<211> 729
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 421
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Lys Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Gln Gly Gly Gly Arg Trp His Pro Tyr Gly Tyr Tyr Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Ser Asp Asp Lys Met Ala His His Thr 
        355                 360                 365             


Leu Leu Leu Gly Ser Gly His Val Gly Leu Arg Asn Leu Gly Asn Thr 
    370                 375                 380                 


Cys Phe Leu Asn Ala Val Leu Gln Cys Leu Ser Ser Thr Arg Pro Leu 
385                 390                 395                 400 


Arg Asp Phe Cys Leu Arg Arg Asp Phe Arg Gln Glu Val Pro Gly Gly 
                405                 410                 415     


Gly Arg Ala Gln Glu Leu Thr Glu Ala Phe Ala Asp Val Ile Gly Ala 
            420                 425                 430         


Leu Trp His Pro Asp Ser Cys Glu Ala Val Asn Pro Thr Arg Phe Arg 
        435                 440                 445             


Ala Val Phe Gln Lys Tyr Val Pro Ser Phe Ser Gly Tyr Ser Gln Gln 
    450                 455                 460                 


Asp Ala Gln Glu Phe Leu Lys Leu Leu Met Glu Arg Leu His Leu Glu 
465                 470                 475                 480 


Ile Asn Arg Arg Gly Arg Arg Ala Pro Pro Ile Leu Ala Asn Gly Pro 
                485                 490                 495     


Val Pro Ser Pro Pro Arg Arg Gly Gly Ala Leu Leu Glu Glu Pro Glu 
            500                 505                 510         


Leu Ser Asp Asp Asp Arg Ala Asn Leu Met Trp Lys Arg Tyr Leu Glu 
        515                 520                 525             


Arg Glu Asp Ser Lys Ile Val Asp Leu Phe Val Gly Gln Leu Lys Ser 
    530                 535                 540                 


Cys Leu Lys Cys Gln Ala Cys Gly Tyr Arg Ser Thr Thr Phe Glu Val 
545                 550                 555                 560 


Phe Cys Asp Leu Ser Leu Pro Ile Pro Lys Lys Gly Phe Ala Gly Gly 
                565                 570                 575     


Lys Val Ser Leu Arg Asp Cys Phe Asn Leu Phe Thr Lys Glu Glu Glu 
            580                 585                 590         


Leu Glu Ser Glu Asn Ala Pro Val Cys Asp Arg Cys Arg Gln Lys Thr 
        595                 600                 605             


Arg Ser Thr Lys Lys Leu Thr Val Gln Arg Phe Pro Arg Ile Leu Val 
    610                 615                 620                 


Leu His Leu Asn Arg Phe Ser Ala Ser Arg Gly Ser Ile Lys Lys Ser 
625                 630                 635                 640 


Ser Val Gly Val Asp Phe Pro Leu Gln Arg Leu Ser Leu Gly Asp Phe 
                645                 650                 655     


Ala Ser Asp Lys Ala Gly Ser Pro Val Tyr Gln Leu Tyr Ala Leu Cys 
            660                 665                 670         


Asn His Ser Gly Ser Val His Tyr Gly His Tyr Thr Ala Leu Cys Arg 
        675                 680                 685             


Cys Gln Thr Gly Trp His Val Tyr Asn Asp Ser Arg Val Ser Pro Val 
    690                 695                 700                 


Ser Glu Asn Gln Val Ala Ser Ser Glu Gly Tyr Val Leu Phe Tyr Gln 
705                 710                 715                 720 


Leu Met Gln Glu Pro Pro Arg Cys Leu 
                725                 


<210> 422
<211> 534
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 422
Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Trp Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Ile Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Gly 
225                 230                 235                 240 


Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu 
                245                 250                 255     


Glu Asn Pro Gly Pro Gly Ser Val Ser Ser Val Pro Thr Lys Leu Glu 
            260                 265                 270         


Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro 
        275                 280                 285             


Ala Val Thr Val Val His Tyr Val Ile Thr Tyr Gly Glu Thr Gly Gly 
    290                 295                 300                 


Asn Ser Pro Val Gln Lys Phe Lys Val Pro Gly Ser Lys Ser Thr Ala 
305                 310                 315                 320 


Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr 
                325                 330                 335     


Ala Tyr Gln Gly Gly Gly Arg Trp His Pro Tyr Gly Tyr Tyr Ser Pro 
            340                 345                 350         


Ile Ser Ile Asn Tyr Arg Thr Ala Thr Pro Met Asp Ala Tyr Leu Arg 
        355                 360                 365             


Lys Leu Gly Leu Tyr Arg Lys Leu Val Ala Lys Asp Gly Ser Cys Leu 
    370                 375                 380                 


Phe Arg Ala Val Ala Glu Gln Val Leu His Ser Gln Ser Arg His Val 
385                 390                 395                 400 


Glu Val Arg Met Ala Cys Ile His Tyr Leu Arg Glu Asn Arg Glu Lys 
                405                 410                 415     


Phe Glu Ala Phe Ile Glu Gly Ser Phe Glu Glu Tyr Leu Lys Arg Leu 
            420                 425                 430         


Glu Asn Pro Gln Glu Trp Val Gly Gln Val Glu Ile Ser Ala Leu Ser 
        435                 440                 445             


Leu Met Tyr Arg Lys Asp Phe Ile Ile Tyr Arg Glu Pro Asn Val Ser 
    450                 455                 460                 


Pro Ser Gln Val Thr Glu Asn Asn Phe Pro Glu Lys Val Leu Leu Cys 
465                 470                 475                 480 


Phe Ser Asn Gly Asn His Tyr Asp Ile Val Tyr Pro Ile Lys Tyr Lys 
                485                 490                 495     


Glu Ser Ser Ala Met Cys Gln Ser Leu Leu Tyr Glu Leu Leu Tyr Glu 
            500                 505                 510         


Lys Val Phe Lys Thr Asp Val Ser Lys Ile Val Met Glu Leu Asp Thr 
        515                 520                 525             


Leu Glu Val Ala Asp Glu 
    530                 


<210> 423
<211> 394
<212> PRT
<213> Homo sapiens

<400> 423
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 424
<211> 76
<212> PRT
<213> Homo sapiens

<400> 424
Met Ser Lys Ala His Pro Pro Glu Leu Lys Lys Phe Met Asp Lys Lys 
1               5                   10                  15      


Leu Ser Leu Lys Leu Asn Gly Gly Arg His Val Gln Gly Ile Leu Arg 
            20                  25                  30          


Gly Phe Asp Pro Phe Met Asn Leu Val Ile Asp Glu Cys Val Glu Met 
        35                  40                  45              


Ala Thr Ser Gly Gln Gln Asn Asn Ile Gly Met Val Val Ile Arg Gly 
    50                  55                  60                  


Asn Ser Ile Ile Met Leu Glu Ala Leu Glu Arg Val 
65                  70                  75      


<210> 425
<211> 95
<212> PRT
<213> Homo sapiens

<400> 425
Met Leu Phe Tyr Ser Phe Phe Lys Ser Leu Val Gly Lys Asp Val Val 
1               5                   10                  15      


Val Glu Leu Lys Asn Asp Leu Ser Ile Cys Gly Thr Leu His Ser Val 
            20                  25                  30          


Asp Gln Tyr Leu Asn Ile Lys Leu Thr Asp Ile Ser Val Thr Asp Pro 
        35                  40                  45              


Glu Lys Tyr Pro His Met Leu Ser Val Lys Asn Cys Phe Ile Arg Gly 
    50                  55                  60                  


Ser Val Val Arg Tyr Val Gln Leu Pro Ala Asp Glu Val Asp Thr Gln 
65                  70                  75                  80  


Leu Leu Gln Asp Ala Ala Arg Lys Glu Ala Leu Gln Gln Lys Gln 
                85                  90                  95  


<210> 426
<211> 97
<212> PRT
<213> Homo sapiens

<400> 426
Met Glu Ala Pro Ala Glu Arg Ala Leu Pro Arg Leu Gln Ala Leu Ala 
1               5                   10                  15      


Arg Pro Pro Pro Pro Ile Ser Tyr Glu Glu Glu Leu Tyr Asp Cys Leu 
            20                  25                  30          


Asp Tyr Tyr Tyr Leu Arg Asp Phe Pro Ala Cys Gly Ala Gly Arg Ser 
        35                  40                  45              


Lys Gly Arg Thr Arg Arg Glu Gln Ala Leu Arg Thr Asn Trp Pro Ala 
    50                  55                  60                  


Pro Gly Gly His Glu Arg Lys Val Ala Gln Lys Leu Leu Asn Gly Gln 
65                  70                  75                  80  


Arg Lys Arg Arg Gln Arg Gln Leu His Pro Lys Met Arg Thr Arg Leu 
                85                  90                  95      


Thr 
    


<210> 427
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 427
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 428
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 428
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 429
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 429
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 430
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 430
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 431
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 431
Gly Gly Gly Gly Ser 
1               5   


<210> 432
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 432
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 433
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 433
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210> 434
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 434
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10  


<210> 435
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 435
Ser Gly Gly Gly Gly 
1               5   


<210> 436
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 436
Gly Gly Ser Gly Gly 
1               5   


<210> 437
<211> 170
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 437
Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
            20                  25                  30          


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
        35                  40                  45              


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
145                 150                 155                 160 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
                165                 170 


<210> 438
<211> 554
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 438
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys 
545                 550                 


<210> 439
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 439
Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu Pro 
1               5                   10                  15  


<210> 440
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 440
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 441
<211> 394
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 441
Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly Ser Arg Thr Pro Glu Lys 
1               5                   10                  15      


Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro Pro Arg Pro Ile Leu Gln 
            20                  25                  30          


Arg Gln Asp Asp Ile Val Gln Glu Lys Arg Leu Ser Arg Gly Ile Ser 
        35                  40                  45              


His Ala Ser Ser Ser Ile Val Ser Leu Ala Arg Ser His Val Ser Ser 
    50                  55                  60                  


Asn Gly Gly Gly Gly Gly Ser Asn Glu His Pro Leu Glu Met Pro Ile 
65                  70                  75                  80  


Cys Ala Phe Gln Leu Pro Asp Leu Thr Val Tyr Asn Glu Asp Phe Arg 
                85                  90                  95      


Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln Ser Met Leu Val Ala Leu 
            100                 105                 110         


Glu Gln Ala Gly Arg Leu Asn Trp Trp Val Ser Val Asp Pro Thr Ser 
        115                 120                 125             


Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly Asp Gly Asn Cys Leu Leu 
    130                 135                 140                 


His Ala Ala Ser Leu Gly Met Trp Gly Phe His Asp Arg Asp Leu Met 
145                 150                 155                 160 


Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu Lys Gly Val Glu Lys Glu 
                165                 170                 175     


Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln Thr Gln Gln Asn Lys Glu 
            180                 185                 190         


Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp Gln Lys Glu Trp Asn Glu 
        195                 200                 205             


Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg Met His Leu Gly Thr Asn 
    210                 215                 220                 


Gly Ala Asn Cys Gly Gly Val Glu Ser Ser Glu Glu Pro Val Tyr Glu 
225                 230                 235                 240 


Ser Leu Glu Glu Phe His Val Phe Val Leu Ala His Val Leu Arg Arg 
                245                 250                 255     


Pro Ile Val Val Val Ala Asp Thr Met Leu Arg Asp Ser Gly Gly Glu 
            260                 265                 270         


Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile Tyr Leu Pro Leu Glu Val 
        275                 280                 285             


Pro Ala Ser Gln Cys His Arg Ser Pro Leu Val Leu Ala Tyr Asp Gln 
    290                 295                 300                 


Ala His Phe Ser Ala Leu Val Ser Met Glu Gln Lys Glu Asn Thr Lys 
305                 310                 315                 320 


Glu Gln Ala Val Ile Pro Leu Thr Asp Ser Glu Tyr Lys Leu Leu Pro 
                325                 330                 335     


Leu His Phe Ala Val Asp Pro Gly Lys Gly Trp Glu Trp Gly Lys Asp 
            340                 345                 350         


Asp Ser Asp Asn Val Arg Leu Ala Ser Val Ile Leu Ser Leu Glu Val 
        355                 360                 365             


Lys Leu His Leu Leu His Ser Tyr Met Asn Val Lys Trp Ile Pro Leu 
    370                 375                 380                 


Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
385                 390                 


<210> 442
<211> 1635
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 442
Met Ser Ile Ala Ile Pro Leu Gly Val Thr Thr Ser Asp Thr Ser Tyr 
1               5                   10                  15      


Ser Asp Met Ala Ala Gly Ser Asp Pro Glu Ser Val Glu Ala Ser Pro 
            20                  25                  30          


Ala Val Asn Glu Lys Ser Val Tyr Ser Thr His Asn Tyr Gly Thr Thr 
        35                  40                  45              


Gln Arg His Gly Cys Arg Gly Leu Pro Tyr Ala Thr Ile Ile Pro Arg 
    50                  55                  60                  


Ser Asp Leu Asn Gly Leu Pro Ser Pro Val Glu Glu Arg Cys Gly Asp 
65                  70                  75                  80  


Ser Pro Asn Ser Glu Gly Glu Thr Val Pro Thr Trp Cys Pro Cys Gly 
                85                  90                  95      


Leu Ser Gln Asp Gly Phe Leu Leu Asn Cys Asp Lys Cys Arg Gly Met 
            100                 105                 110         


Ser Arg Gly Lys Val Ile Arg Leu His Arg Arg Lys Gln Asp Asn Ile 
        115                 120                 125             


Ser Gly Gly Asp Ser Ser Ala Thr Glu Ser Trp Asp Glu Glu Leu Ser 
    130                 135                 140                 


Pro Ser Thr Val Leu Tyr Thr Ala Thr Gln His Thr Pro Thr Ser Ile 
145                 150                 155                 160 


Thr Leu Thr Val Arg Arg Thr Lys Pro Lys Lys Arg Lys Lys Ser Pro 
                165                 170                 175     


Glu Lys Gly Arg Ala Ala Pro Lys Thr Lys Lys Ile Lys Asn Ser Pro 
            180                 185                 190         


Ser Glu Ala Gln Asn Leu Asp Glu Asn Thr Thr Glu Gly Trp Glu Asn 
        195                 200                 205             


Arg Ile Arg Leu Trp Thr Asp Gln Tyr Glu Glu Ala Phe Thr Asn Gln 
    210                 215                 220                 


Tyr Ser Ala Asp Val Gln Asn Ala Leu Glu Gln His Leu His Ser Ser 
225                 230                 235                 240 


Lys Glu Phe Val Gly Lys Pro Thr Ile Leu Asp Thr Ile Asn Lys Thr 
                245                 250                 255     


Glu Leu Ala Cys Asn Asn Thr Val Ile Gly Ser Gln Met Gln Leu Gln 
            260                 265                 270         


Leu Gly Arg Val Thr Arg Val Gln Lys His Arg Lys Ile Leu Arg Ala 
        275                 280                 285             


Ala Arg Asp Leu Ala Leu Asp Thr Leu Ile Ile Glu Tyr Arg Gly Lys 
    290                 295                 300                 


Val Met Leu Arg Gln Gln Phe Glu Val Asn Gly His Phe Phe Lys Lys 
305                 310                 315                 320 


Pro Tyr Pro Phe Val Leu Phe Tyr Ser Lys Phe Asn Gly Val Glu Met 
                325                 330                 335     


Cys Val Asp Ala Arg Thr Phe Gly Asn Asp Ala Arg Phe Ile Arg Arg 
            340                 345                 350         


Ser Cys Thr Pro Asn Ala Glu Val Arg His Met Ile Ala Asp Gly Met 
        355                 360                 365             


Ile His Leu Cys Ile Tyr Ala Val Ser Ala Ile Thr Lys Asp Ala Glu 
    370                 375                 380                 


Val Thr Ile Ala Phe Asp Tyr Glu Tyr Ser Asn Cys Asn Tyr Lys Val 
385                 390                 395                 400 


Asp Cys Ala Cys His Lys Gly Asn Arg Asn Cys Pro Ile Gln Lys Arg 
                405                 410                 415     


Asn Pro Asn Ala Thr Glu Leu Pro Leu Leu Pro Pro Pro Pro Ser Leu 
            420                 425                 430         


Pro Thr Ile Gly Ala Glu Thr Arg Arg Arg Lys Ala Arg Arg Lys Glu 
        435                 440                 445             


Leu Glu Met Glu Gln Gln Asn Glu Ala Ser Glu Glu Asn Asn Asp Gln 
    450                 455                 460                 


Gln Ser Gln Glu Val Pro Glu Lys Val Thr Val Ser Ser Asp His Glu 
465                 470                 475                 480 


Glu Val Asp Asn Pro Glu Glu Lys Pro Glu Glu Glu Lys Glu Glu Val 
                485                 490                 495     


Ile Asp Asp Gln Glu Asn Leu Ala His Ser Arg Arg Thr Arg Glu Asp 
            500                 505                 510         


Arg Lys Val Glu Ala Ile Met His Ala Phe Glu Asn Leu Glu Lys Arg 
        515                 520                 525             


Lys Lys Arg Arg Asp Gln Pro Leu Glu Gln Ser Asn Ser Asp Val Glu 
    530                 535                 540                 


Ile Thr Thr Thr Thr Ser Glu Thr Pro Val Gly Glu Glu Thr Lys Thr 
545                 550                 555                 560 


Glu Ala Pro Glu Ser Glu Val Ser Asn Ser Val Ser Asn Val Thr Ile 
                565                 570                 575     


Pro Ser Thr Pro Gln Ser Val Gly Val Asn Thr Arg Arg Ser Ser Gln 
            580                 585                 590         


Ala Gly Asp Ile Ala Ala Glu Lys Leu Val Pro Lys Pro Pro Pro Ala 
        595                 600                 605             


Lys Pro Ser Arg Pro Arg Pro Lys Ser Arg Ile Ser Arg Tyr Arg Thr 
    610                 615                 620                 


Ser Ser Ala Gln Arg Leu Lys Arg Gln Lys Gln Ala Asn Ala Gln Gln 
625                 630                 635                 640 


Ala Glu Leu Ser Gln Ala Ala Leu Glu Glu Gly Gly Ser Asn Ser Leu 
                645                 650                 655     


Val Thr Pro Thr Glu Ala Gly Ser Leu Asp Ser Ser Gly Glu Asn Arg 
            660                 665                 670         


Pro Leu Thr Gly Ser Asp Pro Thr Val Val Ser Ile Thr Gly Ser His 
        675                 680                 685             


Val Asn Arg Ala Ala Ser Lys Tyr Pro Lys Thr Lys Lys Tyr Leu Val 
    690                 695                 700                 


Thr Glu Trp Leu Asn Asp Lys Ala Glu Lys Gln Glu Cys Pro Val Glu 
705                 710                 715                 720 


Cys Pro Leu Arg Ile Thr Thr Asp Pro Thr Val Leu Ala Thr Thr Leu 
                725                 730                 735     


Asn Met Leu Pro Gly Leu Ile His Ser Pro Leu Ile Cys Thr Thr Pro 
            740                 745                 750         


Lys His Tyr Ile Arg Phe Gly Ser Pro Phe Ile Pro Glu Arg Arg Arg 
        755                 760                 765             


Arg Pro Leu Leu Pro Asp Gly Thr Phe Ser Ser Cys Lys Lys Arg Trp 
    770                 775                 780                 


Ile Lys Gln Ala Leu Glu Glu Gly Met Thr Gln Thr Ser Ser Val Pro 
785                 790                 795                 800 


Gln Glu Thr Arg Thr Gln His Leu Tyr Gln Ser Asn Glu Asn Ser Ser 
                805                 810                 815     


Ser Ser Ser Ile Cys Lys Asp Asn Ala Asp Leu Leu Ser Pro Leu Lys 
            820                 825                 830         


Lys Trp Lys Ser Arg Tyr Leu Met Glu Gln Asn Val Thr Lys Leu Leu 
        835                 840                 845             


Arg Pro Leu Ser Pro Val Thr Pro Pro Pro Pro Asn Ser Gly Ser Lys 
    850                 855                 860                 


Ser Pro Gln Leu Ala Thr Pro Gly Ser Ser His Pro Gly Glu Glu Glu 
865                 870                 875                 880 


Cys Arg Asn Gly Tyr Ser Leu Met Phe Ser Pro Val Thr Ser Leu Thr 
                885                 890                 895     


Thr Ala Ser Arg Cys Asn Thr Pro Leu Gln Phe Glu Leu Cys His Arg 
            900                 905                 910         


Lys Asp Leu Asp Leu Ala Lys Val Gly Tyr Leu Asp Ser Asn Thr Asn 
        915                 920                 925             


Ser Cys Ala Asp Arg Pro Ser Leu Leu Asn Ser Gly His Ser Asp Leu 
    930                 935                 940                 


Ala Pro His Pro Ser Leu Gly Pro Thr Ser Glu Thr Gly Phe Pro Ser 
945                 950                 955                 960 


Arg Ser Gly Asp Gly His Gln Thr Leu Val Arg Asn Ser Asp Gln Ala 
                965                 970                 975     


Phe Arg Thr Glu Phe Asn Leu Met Tyr Ala Tyr Ser Pro Leu Asn Ala 
            980                 985                 990         


Met Pro Arg Ala Asp Gly Leu Tyr  Arg Gly Ser Pro Leu  Val Gly Asp 
        995                 1000                 1005             


Arg Lys  Pro Leu His Leu Asp  Gly Gly Tyr Cys Ser  Pro Ala Glu 
    1010                 1015                 1020             


Gly Phe  Ser Ser Arg Tyr Glu  His Gly Leu Met Lys  Asp Leu Ser 
    1025                 1030                 1035             


Arg Gly  Ser Leu Ser Pro Gly  Gly Glu Arg Ala Cys  Glu Gly Val 
    1040                 1045                 1050             


Pro Ser  Ala Pro Gln Asn Pro  Pro Gln Arg Lys Lys  Val Ser Leu 
    1055                 1060                 1065             


Leu Glu  Tyr Arg Lys Arg Lys  Gln Glu Ala Lys Glu  Asn Ser Ala 
    1070                 1075                 1080             


Gly Gly  Gly Gly Asp Ser Ala  Gln Ser Lys Ser Lys  Ser Ala Gly 
    1085                 1090                 1095             


Ala Gly  Gln Gly Ser Ser Asn  Ser Val Ser Asp Thr  Gly Ala His 
    1100                 1105                 1110             


Gly Val  Gln Gly Ser Ser Ala  Arg Thr Pro Ser Ser  Pro His Lys 
    1115                 1120                 1125             


Lys Phe  Ser Pro Ser His Ser  Ser Met Ser His Leu  Glu Ala Val 
    1130                 1135                 1140             


Ser Pro  Ser Asp Ser Arg Gly  Thr Ser Ser Ser His  Cys Arg Pro 
    1145                 1150                 1155             


Gln Glu  Asn Ile Ser Ser Arg  Trp Met Val Pro Thr  Ser Val Glu 
    1160                 1165                 1170             


Arg Leu  Arg Glu Gly Gly Ser  Ile Pro Lys Val Leu  Arg Ser Ser 
    1175                 1180                 1185             


Val Arg  Val Ala Gln Lys Gly  Glu Pro Ser Pro Thr  Trp Glu Ser 
    1190                 1195                 1200             


Asn Ile  Thr Glu Lys Asp Ser  Asp Pro Ala Asp Gly  Glu Gly Pro 
    1205                 1210                 1215             


Glu Thr  Leu Ser Ser Ala Leu  Ser Lys Gly Ala Thr  Val Tyr Ser 
    1220                 1225                 1230             


Pro Ser  Arg Tyr Ser Tyr Gln  Leu Leu Gln Cys Asp  Ser Pro Arg 
    1235                 1240                 1245             


Thr Glu  Ser Gln Ser Leu Leu  Gln Gln Ser Ser Ser  Pro Phe Arg 
    1250                 1255                 1260             


Gly His  Pro Thr Gln Ser Pro  Gly Tyr Ser Tyr Arg  Thr Thr Ala 
    1265                 1270                 1275             


Leu Arg  Pro Gly Asn Pro Pro  Ser His Gly Ser Ser  Glu Ser Ser 
    1280                 1285                 1290             


Leu Ser  Ser Thr Ser Tyr Ser  Ser Pro Ala His Pro  Val Ser Thr 
    1295                 1300                 1305             


Asp Ser  Leu Ala Pro Phe Thr  Gly Thr Pro Gly Tyr  Phe Ser Ser 
    1310                 1315                 1320             


Gln Pro  His Ser Gly Asn Ser  Thr Gly Ser Asn Leu  Pro Arg Arg 
    1325                 1330                 1335             


Ser Cys  Pro Ser Ser Ala Ala  Ser Pro Thr Leu Gln  Gly Pro Ser 
    1340                 1345                 1350             


Asp Ser  Pro Thr Ser Asp Ser  Val Ser Gln Ser Ser  Thr Gly Thr 
    1355                 1360                 1365             


Leu Ser  Ser Thr Ser Phe Pro  Gln Asn Ser Arg Ser  Ser Leu Pro 
    1370                 1375                 1380             


Ser Asp  Leu Arg Thr Ile Ser  Leu Pro Ser Ala Gly  Gln Ser Ala 
    1385                 1390                 1395             


Val Tyr  Gln Ala Ser Arg Val  Ser Ala Val Ser Asn  Ser Gln His 
    1400                 1405                 1410             


Tyr Pro  His Arg Gly Ser Gly  Gly Val His Gln Tyr  Arg Leu Gln 
    1415                 1420                 1425             


Pro Leu  Gln Gly Ser Gly Val  Lys Thr Gln Thr Gly  Leu Ser Lys 
    1430                 1435                 1440             


Val Pro  Val Phe Thr Leu Glu  Asp Phe Val Gly Asp  Trp Arg Gln 
    1445                 1450                 1455             


Thr Ala  Gly Tyr Asn Leu Asp  Gln Val Leu Glu Gln  Gly Gly Val 
    1460                 1465                 1470             


Ser Ser  Leu Phe Gln Asn Leu  Gly Val Ser Val Thr  Pro Ile Gln 
    1475                 1480                 1485             


Arg Ile  Val Leu Ser Gly Glu  Asn Gly Leu Lys Ile  Asp Ile His 
    1490                 1495                 1500             


Val Ile  Ile Pro Tyr Glu Gly  Leu Ser Gly Asp Gln  Met Gly Gln 
    1505                 1510                 1515             


Ile Glu  Lys Ile Phe Lys Val  Val Tyr Pro Val Asp  Asp His His 
    1520                 1525                 1530             


Phe Lys  Val Ile Leu His Tyr  Gly Thr Leu Val Ile  Asp Gly Val 
    1535                 1540                 1545             


Thr Pro  Asn Met Ile Asp Tyr  Phe Gly Arg Pro Tyr  Glu Gly Ile 
    1550                 1555                 1560             


Ala Val  Phe Asp Gly Lys Lys  Ile Thr Val Thr Gly  Thr Leu Trp 
    1565                 1570                 1575             


Asn Gly  Asn Lys Ile Ile Asp  Glu Arg Leu Ile Asn  Pro Asp Gly 
    1580                 1585                 1590             


Ser Leu  Leu Phe Arg Val Thr  Ile Asn Gly Val Thr  Gly Trp Arg 
    1595                 1600                 1605             


Leu Cys  Glu Arg Ile Leu Ala  Gly Gly Gly Gly Ser  Pro Ser Arg 
    1610                 1615                 1620             


Leu Glu  Glu Glu Leu Arg Arg  Arg Leu Thr Glu Pro  
    1625                 1630                 1635 


<210> 443
<211> 2099
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 443
Met Gln Ser Phe Arg Glu Arg Cys Gly Phe His Gly Lys Gln Gln Asn 
1               5                   10                  15      


Tyr Gln Gln Thr Ser Gln Glu Thr Ser Arg Leu Glu Asn Tyr Arg Gln 
            20                  25                  30          


Pro Ser Gln Ala Gly Leu Ser Cys Asp Arg Gln Arg Leu Leu Ala Lys 
        35                  40                  45              


Asp Tyr Tyr Asn Pro Gln Pro Tyr Pro Ser Tyr Glu Gly Gly Ala Gly 
    50                  55                  60                  


Thr Pro Ser Gly Thr Ala Ala Ala Val Ala Ala Asp Lys Tyr His Arg 
65                  70                  75                  80  


Gly Ser Lys Ala Leu Pro Thr Gln Gln Gly Leu Gln Gly Arg Pro Ala 
                85                  90                  95      


Phe Pro Gly Tyr Gly Val Gln Asp Ser Ser Pro Tyr Pro Gly Arg Tyr 
            100                 105                 110         


Ala Gly Glu Glu Ser Leu Gln Ala Trp Gly Ala Pro Gln Pro Pro Pro 
        115                 120                 125             


Pro Gln Pro Gln Pro Leu Pro Ala Gly Val Ala Lys Tyr Asp Glu Asn 
    130                 135                 140                 


Leu Met Lys Lys Thr Ala Val Pro Pro Ser Arg Gln Tyr Ala Glu Gln 
145                 150                 155                 160 


Gly Ala Gln Val Pro Phe Arg Thr His Ser Leu His Val Gln Gln Pro 
                165                 170                 175     


Pro Pro Pro Gln Gln Pro Leu Ala Tyr Pro Lys Leu Gln Arg Gln Lys 
            180                 185                 190         


Leu Gln Asn Asp Ile Ala Ser Pro Leu Pro Phe Pro Gln Gly Thr His 
        195                 200                 205             


Phe Pro Gln His Ser Gln Ser Phe Pro Thr Ser Ser Thr Tyr Ser Ser 
    210                 215                 220                 


Ser Val Gln Gly Gly Gly Gln Gly Ala His Ser Tyr Lys Ser Cys Thr 
225                 230                 235                 240 


Ala Pro Thr Ala Gln Pro His Asp Arg Pro Leu Thr Ala Ser Ser Ser 
                245                 250                 255     


Leu Ala Pro Gly Gln Arg Val Gln Asn Leu His Ala Tyr Gln Ser Gly 
            260                 265                 270         


Arg Leu Ser Tyr Asp Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        275                 280                 285             


Gln Gln Gln Ala Leu Gln Ser Arg His His Ala Gln Glu Thr Leu His 
    290                 295                 300                 


Tyr Gln Asn Leu Ala Lys Tyr Gln His Tyr Gly Gln Gln Gly Gln Gly 
305                 310                 315                 320 


Tyr Cys Gln Pro Asp Ala Ala Val Arg Thr Pro Glu Gln Tyr Tyr Gln 
                325                 330                 335     


Thr Phe Ser Pro Ser Ser Ser His Ser Pro Ala Arg Ser Val Gly Arg 
            340                 345                 350         


Ser Pro Ser Tyr Ser Ser Thr Pro Ser Pro Leu Met Pro Asn Leu Glu 
        355                 360                 365             


Asn Phe Pro Tyr Ser Gln Gln Pro Leu Ser Thr Gly Ala Phe Pro Ala 
    370                 375                 380                 


Gly Ile Thr Asp His Ser His Phe Met Pro Leu Leu Asn Pro Ser Pro 
385                 390                 395                 400 


Thr Asp Ala Thr Ser Ser Val Asp Thr Gln Ala Gly Asn Cys Lys Pro 
                405                 410                 415     


Leu Gln Lys Asp Lys Leu Pro Glu Asn Leu Leu Ser Asp Leu Ser Leu 
            420                 425                 430         


Gln Ser Leu Thr Ala Leu Thr Ser Gln Val Glu Asn Ile Ser Asn Thr 
        435                 440                 445             


Val Gln Gln Leu Leu Leu Ser Lys Ala Ala Val Pro Gln Lys Lys Gly 
    450                 455                 460                 


Val Lys Asn Leu Val Ser Arg Thr Pro Glu Gln His Lys Ser Gln His 
465                 470                 475                 480 


Cys Ser Pro Glu Gly Ser Gly Tyr Ser Ala Glu Pro Ala Gly Thr Pro 
                485                 490                 495     


Leu Ser Glu Pro Pro Ser Ser Thr Pro Gln Ser Thr His Ala Glu Pro 
            500                 505                 510         


Gln Glu Ala Asp Tyr Leu Ser Gly Ser Glu Asp Pro Leu Glu Arg Ser 
        515                 520                 525             


Phe Leu Tyr Cys Asn Gln Ala Arg Gly Ser Pro Ala Arg Val Asn Ser 
    530                 535                 540                 


Asn Ser Lys Ala Lys Pro Glu Ser Val Ser Thr Cys Ser Val Thr Ser 
545                 550                 555                 560 


Pro Asp Asp Met Ser Thr Lys Ser Asp Asp Ser Phe Gln Ser Leu His 
                565                 570                 575     


Gly Ser Leu Pro Leu Asp Ser Phe Ser Lys Phe Val Ala Gly Glu Arg 
            580                 585                 590         


Asp Cys Pro Arg Leu Leu Leu Ser Ala Leu Ala Gln Glu Asp Leu Ala 
        595                 600                 605             


Ser Glu Ile Leu Gly Leu Gln Glu Ala Ile Gly Glu Lys Ala Asp Lys 
    610                 615                 620                 


Ala Trp Ala Glu Ala Pro Ser Leu Val Lys Asp Ser Ser Lys Pro Pro 
625                 630                 635                 640 


Phe Ser Leu Glu Asn His Ser Ala Cys Leu Asp Ser Val Ala Lys Ser 
                645                 650                 655     


Ala Trp Pro Arg Pro Gly Glu Pro Glu Ala Leu Pro Asp Ser Leu Gln 
            660                 665                 670         


Leu Asp Lys Gly Gly Asn Ala Lys Asp Phe Ser Pro Gly Leu Phe Glu 
        675                 680                 685             


Asp Pro Ser Val Ala Phe Ala Thr Pro Asp Pro Lys Lys Thr Thr Gly 
    690                 695                 700                 


Pro Leu Ser Phe Gly Thr Lys Pro Thr Leu Gly Val Pro Ala Pro Asp 
705                 710                 715                 720 


Pro Thr Thr Ala Ala Phe Asp Cys Phe Pro Asp Thr Thr Ala Ala Ser 
                725                 730                 735     


Ser Ala Asp Ser Ala Asn Pro Phe Ala Trp Pro Glu Glu Asn Leu Gly 
            740                 745                 750         


Asp Ala Cys Pro Arg Trp Gly Leu His Pro Gly Glu Leu Thr Lys Gly 
        755                 760                 765             


Leu Glu Gln Gly Gly Lys Ala Ser Asp Gly Ile Ser Lys Gly Asp Thr 
    770                 775                 780                 


His Glu Ala Ser Ala Cys Leu Gly Phe Gln Glu Glu Asp Pro Pro Gly 
785                 790                 795                 800 


Glu Lys Val Ala Ser Leu Pro Gly Asp Phe Lys Gln Glu Glu Val Gly 
                805                 810                 815     


Gly Val Lys Glu Glu Ala Gly Gly Leu Leu Gln Cys Pro Glu Val Ala 
            820                 825                 830         


Lys Ala Asp Arg Trp Leu Glu Asp Ser Arg His Cys Cys Ser Thr Ala 
        835                 840                 845             


Asp Phe Gly Asp Leu Pro Leu Leu Pro Pro Thr Ser Arg Lys Glu Asp 
    850                 855                 860                 


Leu Glu Ala Glu Glu Glu Tyr Ser Ser Leu Cys Glu Leu Leu Gly Ser 
865                 870                 875                 880 


Pro Glu Gln Arg Pro Gly Met Gln Asp Pro Leu Ser Pro Lys Ala Pro 
                885                 890                 895     


Leu Ile Cys Thr Lys Glu Glu Val Glu Glu Val Leu Asp Ser Lys Ala 
            900                 905                 910         


Gly Trp Gly Ser Pro Cys His Leu Ser Gly Glu Ser Val Ile Leu Leu 
        915                 920                 925             


Gly Pro Thr Val Gly Thr Glu Ser Lys Val Gln Ser Trp Phe Glu Ser 
    930                 935                 940                 


Ser Leu Ser His Met Lys Pro Gly Glu Glu Gly Pro Asp Gly Glu Arg 
945                 950                 955                 960 


Ala Pro Gly Asp Ser Thr Thr Ser Asp Ala Ser Leu Ala Gln Lys Pro 
                965                 970                 975     


Asn Lys Pro Ala Val Pro Glu Ala Pro Ile Ala Lys Lys Glu Pro Val 
            980                 985                 990         


Pro Arg Gly Lys Ser Leu Arg Ser  Arg Arg Val His Arg  Gly Leu Pro 
        995                 1000                 1005             


Glu Ala  Glu Asp Ser Pro Cys  Arg Ala Pro Val Leu  Pro Lys Asp 
    1010                 1015                 1020             


Leu Leu  Leu Pro Glu Ser Cys  Thr Gly Pro Pro Gln  Gly Gln Met 
    1025                 1030                 1035             


Glu Gly  Ala Gly Ala Pro Gly  Arg Gly Ala Ser Glu  Gly Leu Pro 
    1040                 1045                 1050             


Arg Met  Cys Thr Arg Ser Leu  Thr Ala Leu Ser Glu  Pro Arg Thr 
    1055                 1060                 1065             


Pro Gly  Pro Pro Gly Leu Thr  Thr Thr Pro Ala Pro  Pro Asp Lys 
    1070                 1075                 1080             


Leu Gly  Gly Lys Gln Arg Ala  Ala Phe Lys Ser Gly  Lys Arg Val 
    1085                 1090                 1095             


Gly Lys  Pro Ser Pro Lys Ala  Ala Ser Ser Pro Ser  Asn Pro Ala 
    1100                 1105                 1110             


Ala Leu  Pro Val Ala Ser Asp  Ser Ser Pro Met Gly  Ser Lys Thr 
    1115                 1120                 1125             


Lys Glu  Thr Asp Ser Pro Ser  Thr Pro Gly Lys Asp  Gln Arg Ser 
    1130                 1135                 1140             


Met Ile  Leu Arg Ser Arg Thr  Lys Thr Gln Glu Ile  Phe His Ser 
    1145                 1150                 1155             


Lys Arg  Arg Arg Pro Ser Glu  Gly Arg Leu Pro Asn  Cys Arg Ala 
    1160                 1165                 1170             


Thr Lys  Lys Leu Leu Asp Asn  Ser His Leu Pro Ala  Thr Phe Lys 
    1175                 1180                 1185             


Val Ser  Ser Ser Pro Gln Lys  Glu Gly Arg Val Ser  Gln Arg Ala 
    1190                 1195                 1200             


Arg Val  Pro Lys Pro Gly Ala  Gly Ser Lys Leu Ser  Asp Arg Pro 
    1205                 1210                 1215             


Leu His  Ala Leu Lys Arg Lys  Ser Ala Phe Met Ala  Pro Val Pro 
    1220                 1225                 1230             


Thr Lys  Lys Arg Asn Leu Val  Leu Arg Ser Arg Ser  Ser Ser Ser 
    1235                 1240                 1245             


Ser Asn  Ala Ser Gly Asn Gly  Gly Asp Gly Lys Glu  Glu Arg Pro 
    1250                 1255                 1260             


Glu Gly  Ser Pro Thr Leu Phe  Lys Arg Met Ser Ser  Pro Lys Lys 
    1265                 1270                 1275             


Ala Lys  Pro Thr Lys Gly Asn  Gly Glu Pro Ala Thr  Lys Leu Pro 
    1280                 1285                 1290             


Pro Pro  Glu Thr Pro Asp Ala  Cys Leu Lys Leu Ala  Ser Arg Ala 
    1295                 1300                 1305             


Ala Phe  Gln Gly Ala Met Lys  Thr Lys Val Leu Pro  Pro Arg Lys 
    1310                 1315                 1320             


Gly Arg  Gly Leu Lys Leu Glu  Ala Ile Val Gln Lys  Ile Thr Ser 
    1325                 1330                 1335             


Pro Ser  Leu Lys Lys Phe Ala  Cys Lys Ala Pro Gly  Ala Ser Pro 
    1340                 1345                 1350             


Gly Asn  Pro Leu Ser Pro Ser  Leu Ser Asp Lys Asp  Arg Gly Leu 
    1355                 1360                 1365             


Lys Gly  Ala Gly Gly Ser Pro  Val Gly Val Glu Glu  Gly Leu Val 
    1370                 1375                 1380             


Asn Val  Gly Thr Gly Gln Lys  Leu Pro Thr Ser Gly  Ala Asp Pro 
    1385                 1390                 1395             


Leu Cys  Arg Asn Pro Thr Asn  Arg Ser Leu Lys Gly  Lys Leu Met 
    1400                 1405                 1410             


Asn Ser  Lys Lys Leu Ser Ser  Thr Asp Cys Phe Lys  Thr Glu Ala 
    1415                 1420                 1425             


Phe Thr  Ser Pro Glu Ala Leu  Gln Pro Gly Gly Thr  Ala Leu Ala 
    1430                 1435                 1440             


Pro Lys  Lys Arg Ser Arg Lys  Gly Arg Ala Gly Ala  His Gly Leu 
    1445                 1450                 1455             


Ser Lys  Gly Pro Leu Glu Lys  Arg Pro Tyr Leu Gly  Pro Ala Leu 
    1460                 1465                 1470             


Leu Leu  Thr Pro Arg Asp Arg  Ala Ser Gly Thr Gln  Gly Ala Ser 
    1475                 1480                 1485             


Glu Asp  Asn Ser Gly Gly Gly  Gly Lys Lys Pro Lys  Met Glu Glu 
    1490                 1495                 1500             


Leu Gly  Leu Ala Ser Gln Pro  Pro Glu Gly Arg Pro  Cys Gln Pro 
    1505                 1510                 1515             


Gln Thr  Arg Ala Gln Lys Gln  Pro Gly His Thr Asn  Tyr Ser Ser 
    1520                 1525                 1530             


Tyr Ser  Lys Arg Lys Arg Leu  Thr Arg Gly Arg Ala  Lys Asn Thr 
    1535                 1540                 1545             


Thr Ser  Ser Pro Cys Lys Gly  Arg Ala Lys Arg Arg  Arg Gln Gln 
    1550                 1555                 1560             


Gln Val  Leu Pro Leu Asp Pro  Ala Glu Pro Glu Ile  Arg Leu Lys 
    1565                 1570                 1575             


Tyr Ile  Ser Ser Cys Lys Arg  Leu Arg Ser Asp Ser  Arg Thr Pro 
    1580                 1585                 1590             


Ala Phe  Ser Pro Phe Val Arg  Val Glu Lys Arg Asp  Ala Phe Thr 
    1595                 1600                 1605             


Thr Ile  Cys Thr Val Val Asn  Ser Pro Gly Asp Ala  Pro Lys Pro 
    1610                 1615                 1620             


His Arg  Lys Pro Ser Ser Ser  Ala Ser Ser Ser Ser  Ser Ser Ser 
    1625                 1630                 1635             


Ser Phe  Ser Leu Asp Ala Ala  Gly Ala Ser Leu Ala  Thr Leu Pro 
    1640                 1645                 1650             


Gly Gly  Ser Ile Leu Gln Pro  Arg Pro Ser Leu Pro  Leu Ser Ser 
    1655                 1660                 1665             


Thr Met  His Leu Gly Pro Val  Val Ser Lys Ala Leu  Ser Thr Ser 
    1670                 1675                 1680             


Cys Leu  Val Cys Cys Leu Cys  Gln Asn Pro Ala Asn  Phe Lys Asp 
    1685                 1690                 1695             


Leu Gly  Asp Leu Cys Gly Pro  Tyr Tyr Pro Glu His  Cys Leu Pro 
    1700                 1705                 1710             


Lys Lys  Lys Pro Lys Leu Lys  Glu Lys Val Arg Pro  Glu Gly Thr 
    1715                 1720                 1725             


Cys Glu  Glu Ala Ser Leu Pro  Leu Glu Arg Thr Leu  Lys Gly Pro 
    1730                 1735                 1740             


Glu Cys  Ala Ala Ala Ala Thr  Ala Gly Lys Pro Pro  Arg Pro Asp 
    1745                 1750                 1755             


Gly Pro  Ala Asp Pro Ala Lys  Gln Gly Pro Leu Arg  Thr Ser Ala 
    1760                 1765                 1770             


Arg Gly  Leu Ser Arg Arg Leu  Gln Ser Cys Tyr Cys  Cys Asp Gly 
    1775                 1780                 1785             


Arg Glu  Asp Gly Gly Glu Glu  Ala Ala Pro Ala Asp  Lys Gly Arg 
    1790                 1795                 1800             


Lys His  Glu Cys Ser Lys Glu  Ala Pro Ala Glu Pro  Gly Gly Glu 
    1805                 1810                 1815             


Ala Gln  Glu His Trp Val His  Glu Ala Cys Ala Val  Trp Thr Gly 
    1820                 1825                 1830             


Gly Val  Tyr Leu Val Ala Gly  Lys Leu Phe Gly Leu  Gln Glu Ala 
    1835                 1840                 1845             


Met Lys  Val Ala Val Asp Met  Met Cys Ser Ser Cys  Gln Glu Ala 
    1850                 1855                 1860             


Gly Ala  Thr Ile Gly Cys Cys  His Lys Gly Cys Leu  His Thr Tyr 
    1865                 1870                 1875             


His Tyr  Pro Cys Ala Ser Asp  Ala Gly Cys Ile Phe  Ile Glu Glu 
    1880                 1885                 1890             


Asn Phe  Ser Leu Lys Cys Pro  Lys His Lys Arg Leu  Pro Lys Val 
    1895                 1900                 1905             


Pro Val  Phe Thr Leu Glu Asp  Phe Val Gly Asp Trp  Arg Gln Thr 
    1910                 1915                 1920             


Ala Gly  Tyr Asn Leu Asp Gln  Val Leu Glu Gln Gly  Gly Val Ser 
    1925                 1930                 1935             


Ser Leu  Phe Gln Asn Leu Gly  Val Ser Val Thr Pro  Ile Gln Arg 
    1940                 1945                 1950             


Ile Val  Leu Ser Gly Glu Asn  Gly Leu Lys Ile Asp  Ile His Val 
    1955                 1960                 1965             


Ile Ile  Pro Tyr Glu Gly Leu  Ser Gly Asp Gln Met  Gly Gln Ile 
    1970                 1975                 1980             


Glu Lys  Ile Phe Lys Val Val  Tyr Pro Val Asp Asp  His His Phe 
    1985                 1990                 1995             


Lys Val  Ile Leu His Tyr Gly  Thr Leu Val Ile Asp  Gly Val Thr 
    2000                 2005                 2010             


Pro Asn  Met Ile Asp Tyr Phe  Gly Arg Pro Tyr Glu  Gly Ile Ala 
    2015                 2020                 2025             


Val Phe  Asp Gly Lys Lys Ile  Thr Val Thr Gly Thr  Leu Trp Asn 
    2030                 2035                 2040             


Gly Asn  Lys Ile Ile Asp Glu  Arg Leu Ile Asn Pro  Asp Gly Ser 
    2045                 2050                 2055             


Leu Leu  Phe Arg Val Thr Ile  Asn Gly Val Thr Gly  Trp Arg Leu 
    2060                 2065                 2070             


Cys Glu  Arg Ile Leu Ala Gly  Gly Gly Gly Ser Pro  Ser Arg Leu 
    2075                 2080                 2085             


Glu Glu  Glu Leu Arg Arg Arg  Leu Thr Glu Pro 
    2090                 2095                 


<210> 444
<211> 679
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 444
Met Val Ala Gly Met Leu Gly Leu Arg Glu Glu Lys Ser Glu Asp Gln 
1               5                   10                  15      


Asp Leu Gln Gly Leu Lys Asp Lys Pro Leu Lys Phe Lys Lys Val Lys 
            20                  25                  30          


Lys Asp Lys Lys Glu Glu Lys Glu Gly Lys His Glu Pro Val Gln Pro 
        35                  40                  45              


Ser Ala His His Ser Ala Glu Pro Ala Glu Ala Gly Lys Ala Glu Thr 
    50                  55                  60                  


Ser Glu Gly Ser Gly Ser Ala Pro Ala Val Pro Glu Ala Ser Ala Ser 
65                  70                  75                  80  


Pro Lys Gln Arg Arg Ser Ile Ile Arg Asp Arg Gly Pro Met Tyr Asp 
                85                  90                  95      


Asp Pro Thr Leu Pro Glu Gly Trp Thr Arg Lys Leu Lys Gln Arg Lys 
            100                 105                 110         


Ser Gly Arg Ser Ala Gly Lys Tyr Asp Val Tyr Leu Ile Asn Pro Gln 
        115                 120                 125             


Gly Lys Ala Phe Arg Ser Lys Val Glu Leu Ile Ala Tyr Phe Glu Lys 
    130                 135                 140                 


Val Gly Asp Thr Ser Leu Asp Pro Asn Asp Phe Asp Phe Thr Val Thr 
145                 150                 155                 160 


Gly Arg Gly Ser Pro Ser Arg Arg Glu Gln Lys Pro Pro Lys Lys Pro 
                165                 170                 175     


Lys Ser Pro Lys Ala Pro Gly Thr Gly Arg Gly Arg Gly Arg Pro Lys 
            180                 185                 190         


Gly Ser Gly Thr Thr Arg Pro Lys Ala Ala Thr Ser Glu Gly Val Gln 
        195                 200                 205             


Val Lys Arg Val Leu Glu Lys Ser Pro Gly Lys Leu Leu Val Lys Met 
    210                 215                 220                 


Pro Phe Gln Thr Ser Pro Gly Gly Lys Ala Glu Gly Gly Gly Ala Thr 
225                 230                 235                 240 


Thr Ser Thr Gln Val Met Val Ile Lys Arg Pro Gly Arg Lys Arg Lys 
                245                 250                 255     


Ala Glu Ala Asp Pro Gln Ala Ile Pro Lys Lys Arg Gly Arg Lys Pro 
            260                 265                 270         


Gly Ser Val Val Ala Ala Ala Ala Ala Glu Ala Lys Lys Lys Ala Val 
        275                 280                 285             


Lys Glu Ser Ser Ile Arg Ser Val Gln Glu Thr Val Leu Pro Ile Lys 
    290                 295                 300                 


Lys Arg Lys Thr Arg Glu Thr Val Ser Ile Glu Val Lys Glu Val Val 
305                 310                 315                 320 


Lys Pro Leu Leu Val Ser Thr Leu Gly Glu Lys Ser Gly Lys Gly Leu 
                325                 330                 335     


Lys Thr Cys Lys Ser Pro Gly Arg Lys Ser Lys Glu Ser Ser Pro Lys 
            340                 345                 350         


Gly Arg Ser Ser Ser Ala Ser Ser Pro Pro Lys Lys Glu His His His 
        355                 360                 365             


His His His His Ser Glu Ser Pro Lys Ala Pro Val Pro Leu Leu Pro 
    370                 375                 380                 


Pro Leu Pro Pro Pro Pro Pro Glu Pro Glu Ser Ser Glu Asp Pro Thr 
385                 390                 395                 400 


Ser Pro Pro Glu Pro Gln Asp Leu Ser Ser Ser Val Cys Lys Glu Glu 
                405                 410                 415     


Lys Met Pro Arg Gly Gly Ser Leu Glu Ser Asp Gly Cys Pro Lys Glu 
            420                 425                 430         


Pro Ala Lys Thr Gln Pro Ala Val Ala Thr Ala Ala Thr Ala Ala Glu 
        435                 440                 445             


Lys Tyr Lys His Arg Gly Glu Gly Glu Arg Lys Asp Ile Val Ser Ser 
    450                 455                 460                 


Ser Met Pro Arg Pro Asn Arg Glu Glu Pro Val Asp Ser Arg Thr Pro 
465                 470                 475                 480 


Val Thr Glu Arg Val Ser Lys Val Pro Val Phe Thr Leu Glu Asp Phe 
                485                 490                 495     


Val Gly Asp Trp Arg Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu 
            500                 505                 510         


Glu Gln Gly Gly Val Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val 
        515                 520                 525             


Thr Pro Ile Gln Arg Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile 
    530                 535                 540                 


Asp Ile His Val Ile Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met 
545                 550                 555                 560 


Gly Gln Ile Glu Lys Ile Phe Lys Val Val Tyr Pro Val Asp Asp His 
                565                 570                 575     


His Phe Lys Val Ile Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val 
            580                 585                 590         


Thr Pro Asn Met Ile Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala 
        595                 600                 605             


Val Phe Asp Gly Lys Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly 
    610                 615                 620                 


Asn Lys Ile Ile Asp Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu 
625                 630                 635                 640 


Phe Arg Val Thr Ile Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg 
                645                 650                 655     


Ile Leu Ala Gly Gly Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu 
            660                 665                 670         


Arg Arg Arg Leu Thr Glu Pro 
        675                 


<210> 445
<211> 2021
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 445
Met Met Arg Asn Lys Asp Lys Ser Gln Glu Glu Asp Ser Ser Leu His 
1               5                   10                  15      


Ser Asn Ala Ser Ser His Ser Ala Ser Glu Glu Ala Ser Gly Ser Asp 
            20                  25                  30          


Ser Gly Ser Gln Ser Glu Ser Glu Gln Gly Ser Asp Pro Gly Ser Gly 
        35                  40                  45              


His Gly Ser Glu Ser Asn Ser Ser Ser Glu Ser Ser Glu Ser Gln Ser 
    50                  55                  60                  


Glu Ser Glu Ser Glu Ser Ala Gly Ser Lys Ser Gln Pro Val Leu Pro 
65                  70                  75                  80  


Glu Ala Lys Glu Lys Pro Ala Ser Lys Lys Glu Arg Ile Ala Asp Val 
                85                  90                  95      


Lys Lys Met Trp Glu Glu Tyr Pro Asp Val Tyr Gly Val Arg Arg Ser 
            100                 105                 110         


Asn Arg Ser Arg Gln Glu Pro Ser Arg Phe Asn Ile Lys Glu Glu Ala 
        115                 120                 125             


Ser Ser Gly Ser Glu Ser Gly Ser Pro Lys Arg Arg Gly Gln Arg Gln 
    130                 135                 140                 


Leu Lys Lys Gln Glu Lys Trp Lys Gln Glu Pro Ser Glu Asp Glu Gln 
145                 150                 155                 160 


Glu Gln Gly Thr Ser Ala Glu Ser Glu Pro Glu Gln Lys Lys Val Lys 
                165                 170                 175     


Ala Arg Arg Pro Val Pro Arg Arg Thr Val Pro Lys Pro Arg Val Lys 
            180                 185                 190         


Lys Gln Pro Lys Thr Gln Arg Gly Lys Arg Lys Lys Gln Asp Ser Ser 
        195                 200                 205             


Asp Glu Asp Asp Asp Asp Asp Glu Ala Pro Lys Arg Gln Thr Arg Arg 
    210                 215                 220                 


Arg Ala Ala Lys Asn Val Ser Tyr Lys Glu Asp Asp Asp Phe Glu Thr 
225                 230                 235                 240 


Asp Ser Asp Asp Leu Ile Glu Met Thr Gly Glu Gly Val Asp Glu Gln 
                245                 250                 255     


Gln Asp Asn Ser Glu Thr Ile Glu Lys Val Leu Asp Ser Arg Leu Gly 
            260                 265                 270         


Lys Lys Gly Ala Thr Gly Ala Ser Thr Thr Val Tyr Ala Ile Glu Ala 
        275                 280                 285             


Asn Gly Asp Pro Ser Gly Asp Phe Asp Thr Glu Lys Asp Glu Gly Glu 
    290                 295                 300                 


Ile Gln Tyr Leu Ile Lys Trp Lys Gly Trp Ser Tyr Ile His Ser Thr 
305                 310                 315                 320 


Trp Glu Ser Glu Glu Ser Leu Gln Gln Gln Lys Val Lys Gly Leu Lys 
                325                 330                 335     


Lys Leu Glu Asn Phe Lys Lys Lys Glu Asp Glu Ile Lys Gln Trp Leu 
            340                 345                 350         


Gly Lys Val Ser Pro Glu Asp Val Glu Tyr Phe Asn Cys Gln Gln Glu 
        355                 360                 365             


Leu Ala Ser Glu Leu Asn Lys Gln Tyr Gln Ile Val Glu Arg Val Ile 
    370                 375                 380                 


Ala Val Lys Thr Ser Lys Ser Thr Leu Gly Gln Thr Asp Phe Pro Ala 
385                 390                 395                 400 


His Ser Arg Lys Pro Ala Pro Ser Asn Glu Pro Glu Tyr Leu Cys Lys 
                405                 410                 415     


Trp Met Gly Leu Pro Tyr Ser Glu Cys Ser Trp Glu Asp Glu Ala Leu 
            420                 425                 430         


Ile Gly Lys Lys Phe Gln Asn Cys Ile Asp Ser Phe His Ser Arg Asn 
        435                 440                 445             


Asn Ser Lys Thr Ile Pro Thr Arg Glu Cys Lys Ala Leu Lys Gln Arg 
    450                 455                 460                 


Pro Arg Phe Val Ala Leu Lys Lys Gln Pro Ala Tyr Leu Gly Gly Glu 
465                 470                 475                 480 


Asn Leu Glu Leu Arg Asp Tyr Gln Leu Glu Gly Leu Asn Trp Leu Ala 
                485                 490                 495     


His Ser Trp Cys Lys Asn Asn Ser Val Ile Leu Ala Asp Glu Met Gly 
            500                 505                 510         


Leu Gly Lys Thr Ile Gln Thr Ile Ser Phe Leu Ser Tyr Leu Phe His 
        515                 520                 525             


Gln His Gln Leu Tyr Gly Pro Phe Leu Ile Val Val Pro Leu Ser Thr 
    530                 535                 540                 


Leu Thr Ser Trp Gln Arg Glu Phe Glu Ile Trp Ala Pro Glu Ile Asn 
545                 550                 555                 560 


Val Val Val Tyr Ile Gly Asp Leu Met Ser Arg Asn Thr Ile Arg Glu 
                565                 570                 575     


Tyr Glu Trp Ile His Ser Gln Thr Lys Arg Leu Lys Phe Asn Ala Leu 
            580                 585                 590         


Ile Thr Thr Tyr Glu Ile Leu Leu Lys Asp Lys Thr Val Leu Gly Ser 
        595                 600                 605             


Ile Asn Trp Ala Phe Leu Gly Val Asp Glu Ala His Arg Leu Lys Asn 
    610                 615                 620                 


Asp Asp Ser Leu Leu Tyr Lys Thr Leu Ile Asp Phe Lys Ser Asn His 
625                 630                 635                 640 


Arg Leu Leu Ile Thr Gly Thr Pro Leu Gln Asn Ser Leu Lys Glu Leu 
                645                 650                 655     


Trp Ser Leu Leu His Phe Ile Met Pro Glu Lys Phe Glu Phe Trp Glu 
            660                 665                 670         


Asp Phe Glu Glu Asp His Gly Lys Gly Arg Glu Asn Gly Tyr Gln Ser 
        675                 680                 685             


Leu His Lys Val Leu Glu Pro Phe Leu Leu Arg Arg Val Lys Lys Asp 
    690                 695                 700                 


Val Glu Lys Ser Leu Pro Ala Lys Val Glu Gln Ile Leu Arg Val Glu 
705                 710                 715                 720 


Met Ser Ala Leu Gln Lys Gln Tyr Tyr Lys Trp Ile Leu Thr Arg Asn 
                725                 730                 735     


Tyr Lys Ala Leu Ala Lys Gly Thr Arg Gly Ser Thr Ser Gly Phe Leu 
            740                 745                 750         


Asn Ile Val Met Glu Leu Lys Lys Cys Cys Asn His Cys Tyr Leu Ile 
        755                 760                 765             


Lys Pro Pro Glu Glu Asn Glu Arg Glu Asn Gly Gln Glu Ile Leu Leu 
    770                 775                 780                 


Ser Leu Ile Arg Ser Ser Gly Lys Leu Ile Leu Leu Asp Lys Leu Leu 
785                 790                 795                 800 


Thr Arg Leu Arg Glu Arg Gly Asn Arg Val Leu Ile Phe Ser Gln Met 
                805                 810                 815     


Val Arg Met Leu Asp Ile Leu Ala Glu Tyr Leu Thr Ile Lys His Tyr 
            820                 825                 830         


Pro Phe Gln Arg Leu Asp Gly Ser Ile Lys Gly Glu Ile Arg Lys Gln 
        835                 840                 845             


Ala Leu Asp His Phe Asn Ala Asp Gly Ser Glu Asp Phe Cys Phe Leu 
    850                 855                 860                 


Leu Ser Thr Arg Ala Gly Gly Leu Gly Ile Asn Leu Ala Ser Ala Asp 
865                 870                 875                 880 


Thr Val Val Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu Gln 
                885                 890                 895     


Ala Gln Ala Arg Ala His Arg Ile Gly Gln Lys Lys Gln Val Asn Ile 
            900                 905                 910         


Tyr Arg Leu Val Thr Lys Gly Thr Val Glu Glu Glu Ile Ile Glu Arg 
        915                 920                 925             


Ala Lys Lys Lys Met Val Leu Asp His Leu Val Ile Gln Arg Met Asp 
    930                 935                 940                 


Thr Thr Gly Arg Thr Ile Leu Glu Asn Asn Ser Gly Arg Ser Asn Ser 
945                 950                 955                 960 


Asn Pro Phe Asn Lys Glu Glu Leu Thr Ala Ile Leu Lys Phe Gly Ala 
                965                 970                 975     


Glu Asp Leu Phe Lys Glu Leu Glu Gly Glu Glu Ser Glu Pro Gln Glu 
            980                 985                 990         


Met Asp Ile Asp Glu Ile Leu Arg  Leu Ala Glu Thr Arg  Glu Asn Glu 
        995                 1000                 1005             


Val Ser  Thr Ser Ala Thr Asp  Glu Leu Leu Ser Gln  Phe Lys Val 
    1010                 1015                 1020             


Ala Asn  Phe Ala Thr Met Glu  Asp Glu Glu Glu Leu  Glu Glu Arg 
    1025                 1030                 1035             


Pro His  Lys Asp Trp Asp Glu  Ile Ile Pro Glu Glu  Gln Arg Lys 
    1040                 1045                 1050             


Lys Val  Glu Glu Glu Glu Arg  Gln Lys Glu Leu Glu  Glu Ile Tyr 
    1055                 1060                 1065             


Met Leu  Pro Arg Ile Arg Ser  Ser Thr Lys Lys Ala  Gln Thr Asn 
    1070                 1075                 1080             


Asp Ser  Asp Ser Asp Thr Glu  Ser Lys Arg Gln Ala  Gln Arg Ser 
    1085                 1090                 1095             


Ser Ala  Ser Glu Ser Glu Thr  Glu Asp Ser Asp Asp  Asp Lys Lys 
    1100                 1105                 1110             


Pro Lys  Arg Arg Gly Arg Pro  Arg Ser Val Arg Lys  Asp Leu Val 
    1115                 1120                 1125             


Glu Gly  Phe Thr Asp Ala Glu  Ile Arg Arg Phe Ile  Lys Ala Tyr 
    1130                 1135                 1140             


Lys Lys  Phe Gly Leu Pro Leu  Glu Arg Leu Glu Cys  Ile Ala Arg 
    1145                 1150                 1155             


Asp Ala  Glu Leu Val Asp Lys  Ser Val Ala Asp Leu  Lys Arg Leu 
    1160                 1165                 1170             


Gly Glu  Leu Ile His Asn Ser  Cys Val Ser Ala Met  Gln Glu Tyr 
    1175                 1180                 1185             


Glu Glu  Gln Leu Lys Glu Asn  Ala Ser Glu Gly Lys  Gly Pro Gly 
    1190                 1195                 1200             


Lys Arg  Arg Gly Pro Thr Ile  Lys Ile Ser Gly Val  Gln Val Asn 
    1205                 1210                 1215             


Val Lys  Ser Ile Ile Gln His  Glu Glu Glu Phe Glu  Met Leu His 
    1220                 1225                 1230             


Lys Ser  Ile Pro Val Asp Pro  Glu Glu Lys Lys Lys  Tyr Cys Leu 
    1235                 1240                 1245             


Thr Cys  Arg Val Lys Ala Ala  His Phe Asp Val Glu  Trp Gly Val 
    1250                 1255                 1260             


Glu Asp  Asp Ser Arg Leu Leu  Leu Gly Ile Tyr Glu  His Gly Tyr 
    1265                 1270                 1275             


Gly Asn  Trp Glu Leu Ile Lys  Thr Asp Pro Glu Leu  Lys Leu Thr 
    1280                 1285                 1290             


Asp Lys  Ile Leu Pro Val Glu  Thr Asp Lys Lys Pro  Gln Gly Lys 
    1295                 1300                 1305             


Gln Leu  Gln Thr Arg Ala Asp  Tyr Leu Leu Lys Leu  Leu Arg Lys 
    1310                 1315                 1320             


Gly Leu  Glu Lys Lys Gly Ala  Val Thr Gly Gly Glu  Glu Ala Lys 
    1325                 1330                 1335             


Leu Lys  Lys Arg Lys Pro Arg  Val Lys Lys Glu Asn  Lys Val Pro 
    1340                 1345                 1350             


Arg Leu  Lys Glu Glu His Gly  Ile Glu Leu Ser Ser  Pro Arg His 
    1355                 1360                 1365             


Ser Asp  Asn Pro Ser Glu Glu  Gly Glu Val Lys Asp  Asp Gly Leu 
    1370                 1375                 1380             


Glu Lys  Ser Pro Met Lys Lys  Lys Gln Lys Lys Lys  Glu Asn Lys 
    1385                 1390                 1395             


Glu Asn  Lys Glu Lys Gln Met  Ser Ser Arg Lys Asp  Lys Glu Gly 
    1400                 1405                 1410             


Asp Lys  Glu Arg Lys Lys Ser  Lys Asp Lys Lys Glu  Lys Pro Lys 
    1415                 1420                 1425             


Ser Gly  Asp Ala Lys Ser Ser  Ser Lys Ser Lys Arg  Ser Gln Gly 
    1430                 1435                 1440             


Pro Val  His Ile Thr Ala Gly  Ser Glu Pro Val Pro  Ile Gly Glu 
    1445                 1450                 1455             


Asp Glu  Asp Asp Asp Leu Asp  Gln Glu Thr Phe Ser  Ile Cys Lys 
    1460                 1465                 1470             


Glu Arg  Met Arg Pro Val Lys  Lys Ala Leu Lys Gln  Leu Asp Lys 
    1475                 1480                 1485             


Pro Asp  Lys Gly Leu Asn Val  Gln Glu Gln Leu Glu  His Thr Arg 
    1490                 1495                 1500             


Asn Cys  Leu Leu Lys Ile Gly  Asp Arg Ile Ala Glu  Cys Leu Lys 
    1505                 1510                 1515             


Ala Tyr  Ser Asp Gln Glu His  Ile Lys Leu Trp Arg  Arg Asn Leu 
    1520                 1525                 1530             


Trp Ile  Phe Val Ser Lys Phe  Thr Glu Phe Asp Ala  Arg Lys Leu 
    1535                 1540                 1545             


His Lys  Leu Tyr Lys Met Ala  His Lys Lys Arg Ser  Gln Glu Glu 
    1550                 1555                 1560             


Glu Glu  Gln Lys Lys Lys Asp  Asp Val Thr Gly Gly  Lys Lys Pro 
    1565                 1570                 1575             


Phe Arg  Pro Glu Ala Ser Gly  Ser Ser Arg Asp Ser  Leu Ile Ser 
    1580                 1585                 1590             


Gln Ser  His Thr Ser His Asn  Leu His Pro Gln Lys  Pro His Leu 
    1595                 1600                 1605             


Pro Ala  Ser His Gly Pro Gln  Met His Gly His Pro  Arg Asp Asn 
    1610                 1615                 1620             


Tyr Asn  His Pro Asn Lys Arg  His Phe Ser Asn Ala  Asp Arg Gly 
    1625                 1630                 1635             


Asp Trp  Gln Arg Glu Arg Lys  Phe Asn Tyr Gly Gly  Gly Asn Asn 
    1640                 1645                 1650             


Asn Pro  Pro Trp Gly Ser Asp  Arg His His Gln Tyr  Glu Gln His 
    1655                 1660                 1665             


Trp Tyr  Lys Asp His His Tyr  Gly Asp Arg Arg His  Met Asp Ala 
    1670                 1675                 1680             


His Arg  Ser Gly Ser Tyr Arg  Pro Asn Asn Met Ser  Arg Lys Arg 
    1685                 1690                 1695             


Pro Tyr  Asp Gln Tyr Ser Ser  Asp Arg Asp His Arg  Gly His Arg 
    1700                 1705                 1710             


Asp Tyr  Tyr Asp Arg His His  His Asp Ser Lys Arg  Arg Arg Ser 
    1715                 1720                 1725             


Asp Glu  Phe Arg Pro Gln Asn  Tyr His Gln Gln Asp  Phe Arg Arg 
    1730                 1735                 1740             


Met Ser  Asp His Arg Pro Ala  Met Gly Tyr His Gly  Gln Gly Pro 
    1745                 1750                 1755             


Ser Asp  His Tyr Arg Ser Phe  His Thr Asp Lys Leu  Gly Glu Tyr 
    1760                 1765                 1770             


Lys Gln  Pro Leu Pro Pro Leu  His Pro Ala Val Ser  Asp Pro Arg 
    1775                 1780                 1785             


Ser Pro  Pro Ser Gln Lys Ser  Pro His Asp Ser Lys  Ser Pro Leu 
    1790                 1795                 1800             


Asp His  Arg Ser Pro Leu Glu  Arg Ser Leu Glu Gln  Lys Asn Asn 
    1805                 1810                 1815             


Pro Asp  Tyr Asn Trp Asn Val  Arg Lys Thr Lys Val  Pro Val Phe 
    1820                 1825                 1830             


Thr Leu  Glu Asp Phe Val Gly  Asp Trp Arg Gln Thr  Ala Gly Tyr 
    1835                 1840                 1845             


Asn Leu  Asp Gln Val Leu Glu  Gln Gly Gly Val Ser  Ser Leu Phe 
    1850                 1855                 1860             


Gln Asn  Leu Gly Val Ser Val  Thr Pro Ile Gln Arg  Ile Val Leu 
    1865                 1870                 1875             


Ser Gly  Glu Asn Gly Leu Lys  Ile Asp Ile His Val  Ile Ile Pro 
    1880                 1885                 1890             


Tyr Glu  Gly Leu Ser Gly Asp  Gln Met Gly Gln Ile  Glu Lys Ile 
    1895                 1900                 1905             


Phe Lys  Val Val Tyr Pro Val  Asp Asp His His Phe  Lys Val Ile 
    1910                 1915                 1920             


Leu His  Tyr Gly Thr Leu Val  Ile Asp Gly Val Thr  Pro Asn Met 
    1925                 1930                 1935             


Ile Asp  Tyr Phe Gly Arg Pro  Tyr Glu Gly Ile Ala  Val Phe Asp 
    1940                 1945                 1950             


Gly Lys  Lys Ile Thr Val Thr  Gly Thr Leu Trp Asn  Gly Asn Lys 
    1955                 1960                 1965             


Ile Ile  Asp Glu Arg Leu Ile  Asn Pro Asp Gly Ser  Leu Leu Phe 
    1970                 1975                 1980             


Arg Val  Thr Ile Asn Gly Val  Thr Gly Trp Arg Leu  Cys Glu Arg 
    1985                 1990                 1995             


Ile Leu  Ala Gly Gly Gly Gly  Ser Pro Ser Arg Leu  Glu Glu Glu 
    2000                 2005                 2010             


Leu Arg  Arg Arg Leu Thr Glu  Pro 
    2015                 2020     


<210> 446
<211> 289
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 446
Met Ser Lys Ala His Pro Pro Glu Leu Lys Lys Phe Met Asp Lys Lys 
1               5                   10                  15      


Leu Ser Leu Lys Leu Asn Gly Gly Arg His Val Gln Gly Ile Leu Arg 
            20                  25                  30          


Gly Phe Asp Pro Phe Met Asn Leu Val Ile Asp Glu Cys Val Glu Met 
        35                  40                  45              


Ala Thr Ser Gly Gln Gln Asn Asn Ile Gly Met Val Asp Asn Ile Pro 
    50                  55                  60                  


Asn Lys Ala Val Ser Pro Lys Phe Leu Lys Lys Val Asn Gln Lys Gly 
65                  70                  75                  80  


Gln Leu Thr Phe Ser Lys Leu Leu Ser Ile Lys Thr Ser Lys Glu Trp 
                85                  90                  95      


Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln 
            100                 105                 110         


Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser 
        115                 120                 125             


Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile 
    130                 135                 140                 


Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile 
145                 150                 155                 160 


Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile 
                165                 170                 175     


Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu 
            180                 185                 190         


His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp 
        195                 200                 205             


Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys 
    210                 215                 220                 


Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu 
225                 230                 235                 240 


Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn 
                245                 250                 255     


Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly 
            260                 265                 270         


Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu 
        275                 280                 285             


Pro 
    


<210> 447
<211> 288
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 447
Met Leu Phe Tyr Ser Phe Phe Lys Ser Leu Val Gly Lys Asp Val Val 
1               5                   10                  15      


Val Glu Leu Lys Asn Asp Leu Ser Ile Cys Gly Thr Leu His Ser Val 
            20                  25                  30          


Asp Gln Tyr Leu Asn Ile Lys Leu Thr Asp Ile Ser Val Thr Asp Pro 
        35                  40                  45              


Glu Lys Tyr Pro His Met Leu Ser Val Lys Asn Cys Phe Ile Arg Gly 
    50                  55                  60                  


Ser Val Val Arg Tyr Val Gln Leu Pro Ala Asp Glu Val Asp Thr Gln 
65                  70                  75                  80  


Leu Leu Gln Asp Ala Ala Arg Lys Glu Ala Leu Gln Gln Lys Gln Lys 
                85                  90                  95      


Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr 
            100                 105                 110         


Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser 
        115                 120                 125             


Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val 
    130                 135                 140                 


Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro 
145                 150                 155                 160 


Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe 
                165                 170                 175     


Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His 
            180                 185                 190         


Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr 
        195                 200                 205             


Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile 
    210                 215                 220                 


Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg 
225                 230                 235                 240 


Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly 
                245                 250                 255     


Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly Gly Gly 
            260                 265                 270         


Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu Pro 
        275                 280                 285             


<210> 448
<211> 290
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 448
Met Glu Ala Pro Ala Glu Arg Ala Leu Pro Arg Leu Gln Ala Leu Ala 
1               5                   10                  15      


Arg Pro Pro Pro Pro Ile Ser Tyr Glu Glu Glu Leu Tyr Asp Cys Leu 
            20                  25                  30          


Asp Tyr Tyr Tyr Leu Arg Asp Phe Pro Ala Cys Gly Ala Gly Arg Ser 
        35                  40                  45              


Lys Gly Arg Thr Arg Arg Glu Gln Ala Leu Arg Thr Asn Trp Pro Ala 
    50                  55                  60                  


Pro Gly Gly His Glu Arg Lys Val Ala Gln Lys Leu Leu Asn Gly Gln 
65                  70                  75                  80  


Arg Lys Arg Arg Gln Arg Gln Leu His Pro Lys Met Arg Thr Arg Leu 
                85                  90                  95      


Thr Lys Val Pro Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg 
            100                 105                 110         


Gln Thr Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val 
        115                 120                 125             


Ser Ser Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg 
    130                 135                 140                 


Ile Val Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile 
145                 150                 155                 160 


Ile Pro Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys 
                165                 170                 175     


Ile Phe Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile 
            180                 185                 190         


Leu His Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile 
        195                 200                 205             


Asp Tyr Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys 
    210                 215                 220                 


Lys Ile Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp 
225                 230                 235                 240 


Glu Arg Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile 
                245                 250                 255     


Asn Gly Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Gly 
            260                 265                 270         


Gly Gly Ser Pro Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr 
        275                 280                 285             


Glu Pro 
    290 


<210> 449
<211> 706
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 449
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Glu Val Gln Leu Gln Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
        595                 600                 605             


Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr 
    610                 615                 620                 


Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser Glu 
625                 630                 635                 640 


Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val 
                645                 650                 655     


Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu 
            660                 665                 670         


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg 
        675                 680                 685             


Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    690                 695                 700                 


Ser Ser 
705     


<210> 450
<211> 976
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 450
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Pro Pro Ser Phe Ser Glu Gly Ser Gly Gly 
            580                 585                 590         


Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr Arg Pro 
        595                 600                 605             


Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu Lys Arg 
    610                 615                 620                 


Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser Leu Ala 
625                 630                 635                 640 


Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn Glu His 
                645                 650                 655     


Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu Thr Val 
            660                 665                 670         


Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile Glu Gln 
        675                 680                 685             


Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp Trp Val 
    690                 695                 700                 


Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr Thr Gly 
705                 710                 715                 720 


Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp Gly Phe 
                725                 730                 735     


His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu Met Glu 
            740                 745                 750         


Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp Gln Gln 
        755                 760                 765             


Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp Glu Trp 
    770                 775                 780                 


Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu Pro Arg 
785                 790                 795                 800 


Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu Ser Ser 
                805                 810                 815     


Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe Val Leu 
            820                 825                 830         


Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr Met Leu 
        835                 840                 845             


Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly Gly Ile 
    850                 855                 860                 


Tyr Leu Pro Leu Glu Val Pro Ala Ser Gln Cys His Arg Ser Pro Leu 
865                 870                 875                 880 


Val Leu Ala Tyr Asp Gln Ala His Phe Ser Ala Leu Val Ser Met Glu 
                885                 890                 895     


Gln Lys Glu Asn Thr Lys Glu Gln Ala Val Ile Pro Leu Thr Asp Ser 
            900                 905                 910         


Glu Tyr Lys Leu Leu Pro Leu His Phe Ala Val Asp Pro Gly Lys Gly 
        915                 920                 925             


Trp Glu Trp Gly Lys Asp Asp Ser Asp Asn Val Arg Leu Ala Ser Val 
    930                 935                 940                 


Ile Leu Ser Leu Glu Val Lys Leu His Leu Leu His Ser Tyr Met Asn 
945                 950                 955                 960 


Val Lys Trp Ile Pro Leu Ser Ser Asp Ala Gln Ala Pro Leu Ala Gln 
                965                 970                 975     


<210> 451
<211> 1106
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 451
Met Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro Phe Tyr Pro 
1               5                   10                  15      


Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala Met Lys Arg 
            20                  25                  30          


Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala His Ile Glu 
        35                  40                  45              


Val Asp Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val Arg Leu Ala 
    50                  55                  60                  


Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg Ile Val Val 
65                  70                  75                  80  


Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu Gly Ala Leu 
                85                  90                  95      


Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr Asn Glu Arg 
            100                 105                 110         


Glu Leu Leu Asn Ser Met Gly Ile Ser Gln Pro Thr Val Val Phe Val 
        115                 120                 125             


Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys Lys Leu Pro 
    130                 135                 140                 


Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp Tyr Gln Gly 
145                 150                 155                 160 


Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro Pro Gly Phe 
                165                 170                 175     


Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp Lys Thr Ile 
            180                 185                 190         


Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro Lys Gly Val 
        195                 200                 205             


Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His Ala Arg Asp 
    210                 215                 220                 


Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile Leu Ser Val 
225                 230                 235                 240 


Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu Gly Tyr Leu 
                245                 250                 255     


Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu Glu Glu Leu 
            260                 265                 270         


Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala Leu Leu Val 
        275                 280                 285             


Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile Asp Lys Tyr 
    290                 295                 300                 


Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala Pro Leu Ser 
305                 310                 315                 320 


Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu Pro Gly Ile 
                325                 330                 335     


Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile Leu Ile Thr 
            340                 345                 350         


Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val Val Pro Phe 
        355                 360                 365             


Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr Leu Gly Val 
    370                 375                 380                 


Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile Met Ser Gly 
385                 390                 395                 400 


Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp Lys Asp Gly 
                405                 410                 415     


Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp Glu His Phe 
            420                 425                 430         


Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys Gly Tyr Gln 
        435                 440                 445             


Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His Pro Asn Ile 
    450                 455                 460                 


Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala Gly Glu Leu 
465                 470                 475                 480 


Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met Thr Glu Lys 
                485                 490                 495     


Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala Lys Lys Leu 
            500                 505                 510         


Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly Leu Thr Gly 
        515                 520                 525             


Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys Ala Lys Lys 
    530                 535                 540                 


Gly Gly Lys Ile Ala Val Thr Arg Leu Lys Gly Ser Gly Ala Thr Asn 
545                 550                 555                 560 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
                565                 570                 575     


Arg Ser Gly Thr Gly Ser Ser Gly Glu Val Gln Leu Gln Glu Ser Gly 
            580                 585                 590         


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala 
        595                 600                 605             


Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala Met Gly Trp Tyr 
    610                 615                 620                 


Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala Ala Val Ser Glu 
625                 630                 635                 640 


Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly Arg Phe Thr Val 
                645                 650                 655     


Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln Met Asp Asn Leu 
            660                 665                 670         


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val Leu Glu Asp Arg 
        675                 680                 685             


Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    690                 695                 700                 


Ser Ser Gly Ala Pro Gly Ser Gly Pro Pro Ser Phe Ser Glu Gly Ser 
705                 710                 715                 720 


Gly Gly Ser Arg Thr Pro Glu Lys Gly Phe Ser Asp Arg Glu Pro Thr 
                725                 730                 735     


Arg Pro Pro Arg Pro Ile Leu Gln Arg Gln Asp Asp Ile Val Gln Glu 
            740                 745                 750         


Lys Arg Leu Ser Arg Gly Ile Ser His Ala Ser Ser Ser Ile Val Ser 
        755                 760                 765             


Leu Ala Arg Ser His Val Ser Ser Asn Gly Gly Gly Gly Gly Ser Asn 
    770                 775                 780                 


Glu His Pro Leu Glu Met Pro Ile Cys Ala Phe Gln Leu Pro Asp Leu 
785                 790                 795                 800 


Thr Val Tyr Asn Glu Asp Phe Arg Ser Phe Ile Glu Arg Asp Leu Ile 
                805                 810                 815     


Glu Gln Ser Met Leu Val Ala Leu Glu Gln Ala Gly Arg Leu Asn Trp 
            820                 825                 830         


Trp Val Ser Val Asp Pro Thr Ser Gln Arg Leu Leu Pro Leu Ala Thr 
        835                 840                 845             


Thr Gly Asp Gly Asn Cys Leu Leu His Ala Ala Ser Leu Gly Met Trp 
    850                 855                 860                 


Gly Phe His Asp Arg Asp Leu Met Leu Arg Lys Ala Leu Tyr Ala Leu 
865                 870                 875                 880 


Met Glu Lys Gly Val Glu Lys Glu Ala Leu Lys Arg Arg Trp Arg Trp 
                885                 890                 895     


Gln Gln Thr Gln Gln Asn Lys Glu Ser Gly Leu Val Tyr Thr Glu Asp 
            900                 905                 910         


Glu Trp Gln Lys Glu Trp Asn Glu Leu Ile Lys Leu Ala Ser Ser Glu 
        915                 920                 925             


Pro Arg Met His Leu Gly Thr Asn Gly Ala Asn Cys Gly Gly Val Glu 
    930                 935                 940                 


Ser Ser Glu Glu Pro Val Tyr Glu Ser Leu Glu Glu Phe His Val Phe 
945                 950                 955                 960 


Val Leu Ala His Val Leu Arg Arg Pro Ile Val Val Val Ala Asp Thr 
                965                 970                 975     


Met Leu Arg Asp Ser Gly Gly Glu Ala Phe Ala Pro Ile Pro Phe Gly 
            980                 985                 990         


Gly Ile Tyr Leu Pro Leu Glu Val  Pro Ala Ser Gln Cys  His Arg Ser 
        995                 1000                 1005             


Pro Leu  Val Leu Ala Tyr Asp  Gln Ala His Phe Ser  Ala Leu Val 
    1010                 1015                 1020             


Ser Met  Glu Gln Lys Glu Asn  Thr Lys Glu Gln Ala  Val Ile Pro 
    1025                 1030                 1035             


Leu Thr  Asp Ser Glu Tyr Lys  Leu Leu Pro Leu His  Phe Ala Val 
    1040                 1045                 1050             


Asp Pro  Gly Lys Gly Trp Glu  Trp Gly Lys Asp Asp  Ser Asp Asn 
    1055                 1060                 1065             


Val Arg  Leu Ala Ser Val Ile  Leu Ser Leu Glu Val  Lys Leu His 
    1070                 1075                 1080             


Leu Leu  His Ser Tyr Met Asn  Val Lys Trp Ile Pro  Leu Ser Ser 
    1085                 1090                 1095             


Asp Ala  Gln Ala Pro Leu Ala  Gln 
    1100                 1105     


