                         SEQUENCE LISTING

<110>  Pairwise Plants Services, Inc.
       Kim, Yongjoo
       Watts, Joseph M.
       Hummel, Aaron
       Lawit, Shai J.
       Schwark, David
 
<120>  COMPOSITIONS AND METHODS FOR RNA-ENCODED DNA-REPLACEMENT OF 
       ALLELES

<130>  1499.57.WO

<150>  US 63/110,386
<151>  2020-11-06

<160>  215   

<170>  PatentIn version 3.5

<210>  1
<211>  1228
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  1

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  2
<211>  1307
<212>  PRT
<213>  Acidaminococcus sp.

<400>  2

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp 
    530                 535                 540                 


Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  3
<211>  1241
<212>  PRT
<213>  Utyrivibrio proteoclasticus

<400>  3

Met Leu Leu Tyr Glu Asn Tyr Thr Lys Arg Asn Gln Ile Thr Lys Ser 
1               5                   10                  15      


Leu Arg Leu Glu Leu Arg Pro Gln Gly Lys Thr Leu Arg Asn Ile Lys 
            20                  25                  30          


Glu Leu Asn Leu Leu Glu Gln Asp Lys Ala Ile Tyr Ala Leu Leu Glu 
        35                  40                  45              


Arg Leu Lys Pro Val Ile Asp Glu Gly Ile Lys Asp Ile Ala Arg Asp 
    50                  55                  60                  


Thr Leu Lys Asn Cys Glu Leu Ser Phe Glu Lys Leu Tyr Glu His Phe 
65                  70                  75                  80  


Leu Ser Gly Asp Lys Lys Ala Tyr Ala Lys Glu Ser Glu Arg Leu Lys 
                85                  90                  95      


Lys Glu Ile Val Lys Thr Leu Ile Lys Asn Leu Pro Glu Gly Ile Gly 
            100                 105                 110         


Lys Ile Ser Glu Ile Asn Ser Ala Lys Tyr Leu Asn Gly Val Leu Tyr 
        115                 120                 125             


Asp Phe Ile Asp Lys Thr His Lys Asp Ser Glu Glu Lys Gln Asn Ile 
    130                 135                 140                 


Leu Ser Asp Ile Leu Glu Thr Lys Gly Tyr Leu Ala Leu Phe Ser Lys 
145                 150                 155                 160 


Phe Leu Thr Ser Arg Ile Thr Thr Leu Glu Gln Ser Met Pro Lys Arg 
                165                 170                 175     


Val Ile Glu Asn Phe Glu Ile Tyr Ala Ala Asn Ile Pro Lys Met Gln 
            180                 185                 190         


Asp Ala Leu Glu Arg Gly Ala Val Ser Phe Ala Ile Glu Tyr Glu Ser 
        195                 200                 205             


Ile Cys Ser Val Asp Tyr Tyr Asn Gln Ile Leu Ser Gln Glu Asp Ile 
    210                 215                 220                 


Asp Ser Tyr Asn Arg Leu Ile Ser Gly Ile Met Asp Glu Asp Gly Ala 
225                 230                 235                 240 


Lys Glu Lys Gly Ile Asn Gln Thr Ile Ser Glu Lys Asn Ile Lys Ile 
                245                 250                 255     


Lys Ser Glu His Leu Glu Glu Lys Pro Phe Arg Ile Leu Lys Gln Leu 
            260                 265                 270         


His Lys Gln Ile Leu Glu Glu Arg Glu Lys Ala Phe Thr Ile Asp His 
        275                 280                 285             


Ile Asp Ser Asp Glu Glu Val Val Gln Val Thr Lys Glu Ala Phe Glu 
    290                 295                 300                 


Gln Thr Lys Glu Gln Trp Glu Asn Ile Lys Lys Ile Asn Gly Phe Tyr 
305                 310                 315                 320 


Ala Lys Asp Pro Gly Asp Ile Thr Leu Phe Ile Val Val Gly Pro Asn 
                325                 330                 335     


Gln Thr His Val Leu Ser Gln Leu Ile Tyr Gly Glu His Asp Arg Ile 
            340                 345                 350         


Arg Leu Leu Leu Glu Glu Tyr Glu Lys Asn Thr Leu Glu Val Leu Pro 
        355                 360                 365             


Arg Arg Thr Lys Ser Glu Asp Ala Arg Tyr Asp Lys Phe Val Asn Ala 
    370                 375                 380                 


Val Pro Lys Lys Val Ala Lys Glu Ser His Thr Phe Asp Gly Leu Gln 
385                 390                 395                 400 


Lys Met Thr Gly Asp Asp Arg Leu Phe Ile Leu Tyr Arg Asp Glu Leu 
                405                 410                 415     


Ala Arg Asn Tyr Met Arg Ile Lys Glu Ala Tyr Gly Thr Phe Glu Arg 
            420                 425                 430         


Asp Ile Leu Lys Ser Arg Arg Gly Ile Lys Gly Asn Arg Asp Val Gln 
        435                 440                 445             


Glu Ser Leu Val Ser Phe Tyr Asp Glu Leu Thr Lys Phe Arg Ser Ala 
    450                 455                 460                 


Leu Arg Ile Ile Asn Ser Gly Asn Asp Glu Lys Ala Asp Pro Ile Phe 
465                 470                 475                 480 


Tyr Asn Thr Phe Asp Gly Ile Phe Glu Lys Ala Asn Arg Thr Tyr Lys 
                485                 490                 495     


Ala Glu Asn Leu Cys Arg Asn Tyr Val Thr Lys Ser Pro Ala Asp Asp 
            500                 505                 510         


Ala Arg Ile Met Ala Ser Cys Leu Gly Thr Pro Ala Arg Leu Arg Thr 
        515                 520                 525             


His Trp Trp Asn Gly Glu Glu Asn Phe Ala Ile Asn Asp Val Ala Met 
    530                 535                 540                 


Ile Arg Arg Gly Asp Glu Tyr Tyr Tyr Phe Val Leu Thr Pro Asp Val 
545                 550                 555                 560 


Lys Pro Val Asp Leu Lys Thr Lys Asp Glu Thr Asp Ala Gln Ile Phe 
                565                 570                 575     


Val Gln Arg Lys Gly Ala Lys Ser Phe Leu Gly Leu Pro Lys Ala Leu 
            580                 585                 590         


Phe Lys Cys Ile Leu Glu Pro Tyr Phe Glu Ser Pro Glu His Lys Asn 
        595                 600                 605             


Asp Lys Asn Cys Val Ile Glu Glu Tyr Val Ser Lys Pro Leu Thr Ile 
    610                 615                 620                 


Asp Arg Arg Ala Tyr Asp Ile Phe Lys Asn Gly Thr Phe Lys Lys Thr 
625                 630                 635                 640 


Asn Ile Gly Ile Asp Gly Leu Thr Glu Glu Lys Phe Lys Asp Asp Cys 
                645                 650                 655     


Arg Tyr Leu Ile Asp Val Tyr Lys Glu Phe Ile Ala Val Tyr Thr Arg 
            660                 665                 670         


Tyr Ser Cys Phe Asn Met Ser Gly Leu Lys Arg Ala Asp Glu Tyr Asn 
        675                 680                 685             


Asp Ile Gly Glu Phe Phe Ser Asp Val Asp Thr Arg Leu Cys Thr Met 
    690                 695                 700                 


Glu Trp Ile Pro Val Ser Phe Glu Arg Ile Asn Asp Met Val Asp Lys 
705                 710                 715                 720 


Lys Glu Gly Leu Leu Phe Leu Val Arg Ser Met Phe Leu Tyr Asn Arg 
                725                 730                 735     


Pro Arg Lys Pro Tyr Glu Arg Thr Phe Ile Gln Leu Phe Ser Asp Ser 
            740                 745                 750         


Asn Met Glu His Thr Ser Met Leu Leu Asn Ser Arg Ala Met Ile Gln 
        755                 760                 765             


Tyr Arg Ala Ala Ser Leu Pro Arg Arg Val Thr His Lys Lys Gly Ser 
    770                 775                 780                 


Ile Leu Val Ala Leu Arg Asp Ser Asn Gly Glu His Ile Pro Met His 
785                 790                 795                 800 


Ile Arg Glu Ala Ile Tyr Lys Met Lys Asn Asn Phe Asp Ile Ser Ser 
                805                 810                 815     


Glu Asp Phe Ile Met Ala Lys Ala Tyr Leu Ala Glu His Asp Val Ala 
            820                 825                 830         


Ile Lys Lys Ala Asn Glu Asp Ile Ile Arg Asn Arg Arg Tyr Thr Glu 
        835                 840                 845             


Asp Lys Phe Phe Leu Ser Leu Ser Tyr Thr Lys Asn Ala Asp Ile Ser 
    850                 855                 860                 


Ala Arg Thr Leu Asp Tyr Ile Asn Asp Lys Val Glu Glu Asp Thr Gln 
865                 870                 875                 880 


Asp Ser Arg Met Ala Val Ile Val Thr Arg Asn Leu Lys Asp Leu Thr 
                885                 890                 895     


Tyr Val Ala Val Val Asp Glu Lys Asn Asn Val Leu Glu Glu Lys Ser 
            900                 905                 910         


Leu Asn Glu Ile Asp Gly Val Asn Tyr Arg Glu Leu Leu Lys Glu Arg 
        915                 920                 925             


Thr Lys Ile Lys Tyr His Asp Lys Thr Arg Leu Trp Gln Tyr Asp Val 
    930                 935                 940                 


Ser Ser Lys Gly Leu Lys Glu Ala Tyr Val Glu Leu Ala Val Thr Gln 
945                 950                 955                 960 


Ile Ser Lys Leu Ala Thr Lys Tyr Asn Ala Val Val Val Val Glu Ser 
                965                 970                 975     


Met Ser Ser Thr Phe Lys Asp Lys Phe Ser Phe Leu Asp Glu Gln Ile 
            980                 985                 990         


Phe Lys Ala Phe Glu Ala Arg Leu  Cys Ala Arg Met Ser  Asp Leu Ser 
        995                 1000                 1005             


Phe Asn  Thr Ile Lys Glu Gly  Glu Ala Gly Ser Ile  Ser Asn Pro 
    1010                 1015                 1020             


Ile Gln  Val Ser Asn Asn Asn  Gly Asn Ser Tyr Gln  Asp Gly Val 
    1025                 1030                 1035             


Ile Tyr  Phe Leu Asn Asn Ala  Tyr Thr Arg Thr Leu  Cys Pro Asp 
    1040                 1045                 1050             


Thr Gly  Phe Val Asp Val Phe  Asp Lys Thr Arg Leu  Ile Thr Met 
    1055                 1060                 1065             


Gln Ser  Lys Arg Gln Phe Phe  Ala Lys Met Lys Asp  Ile Arg Ile 
    1070                 1075                 1080             


Asp Asp  Gly Glu Met Leu Phe  Thr Phe Asn Leu Glu  Glu Tyr Pro 
    1085                 1090                 1095             


Thr Lys  Arg Leu Leu Asp Arg  Lys Glu Trp Thr Val  Lys Ile Ala 
    1100                 1105                 1110             


Gly Asp  Gly Ser Tyr Phe Asp  Lys Asp Lys Gly Glu  Tyr Val Tyr 
    1115                 1120                 1125             


Val Asn  Asp Ile Val Arg Glu  Gln Ile Ile Pro Ala  Leu Leu Glu 
    1130                 1135                 1140             


Asp Lys  Ala Val Phe Asp Gly  Asn Met Ala Glu Lys  Phe Leu Asp 
    1145                 1150                 1155             


Lys Thr  Ala Ile Ser Gly Lys  Ser Val Glu Leu Ile  Tyr Lys Trp 
    1160                 1165                 1170             


Phe Ala  Asn Ala Leu Tyr Gly  Ile Ile Thr Lys Lys  Asp Gly Glu 
    1175                 1180                 1185             


Lys Ile  Tyr Arg Ser Pro Ile  Thr Gly Thr Glu Ile  Asp Val Ser 
    1190                 1195                 1200             


Lys Asn  Thr Thr Tyr Asn Phe  Gly Lys Lys Phe Met  Phe Lys Gln 
    1205                 1210                 1215             


Glu Tyr  Arg Gly Asp Gly Asp  Phe Leu Asp Ala Phe  Leu Asn Tyr 
    1220                 1225                 1230             


Met Gln  Ala Gln Asp Ile Ala  Val 
    1235                 1240     


<210>  4
<211>  1238
<212>  PRT
<213>  Candidatus Methanoplasma termitum

<400>  4

Met Asn Asn Tyr Asp Glu Phe Thr Lys Leu Tyr Pro Ile Gln Lys Thr 
1               5                   10                  15      


Ile Arg Phe Glu Leu Lys Pro Gln Gly Arg Thr Met Glu His Leu Glu 
            20                  25                  30          


Thr Phe Asn Phe Phe Glu Glu Asp Arg Asp Arg Ala Glu Lys Tyr Lys 
        35                  40                  45              


Ile Leu Lys Glu Ala Ile Asp Glu Tyr His Lys Lys Phe Ile Asp Glu 
    50                  55                  60                  


His Leu Thr Asn Met Ser Leu Asp Trp Asn Ser Leu Lys Gln Ile Ser 
65                  70                  75                  80  


Glu Lys Tyr Tyr Lys Ser Arg Glu Glu Lys Asp Lys Lys Val Phe Leu 
                85                  90                  95      


Ser Glu Gln Lys Arg Met Arg Gln Glu Ile Val Ser Glu Phe Lys Lys 
            100                 105                 110         


Asp Asp Arg Phe Lys Asp Leu Phe Ser Lys Lys Leu Phe Ser Glu Leu 
        115                 120                 125             


Leu Lys Glu Glu Ile Tyr Lys Lys Gly Asn His Gln Glu Ile Asp Ala 
    130                 135                 140                 


Leu Lys Ser Phe Asp Lys Phe Ser Gly Tyr Phe Ile Gly Leu His Glu 
145                 150                 155                 160 


Asn Arg Lys Asn Met Tyr Ser Asp Gly Asp Glu Ile Thr Ala Ile Ser 
                165                 170                 175     


Asn Arg Ile Val Asn Glu Asn Phe Pro Lys Phe Leu Asp Asn Leu Gln 
            180                 185                 190         


Lys Tyr Gln Glu Ala Arg Lys Lys Tyr Pro Glu Trp Ile Ile Lys Ala 
        195                 200                 205             


Glu Ser Ala Leu Val Ala His Asn Ile Lys Met Asp Ile Val Phe Ser 
    210                 215                 220                 


Leu Glu Tyr Phe Asn Lys Val Leu Asn Gln Glu Gly Ile Gln Arg Tyr 
225                 230                 235                 240 


Asn Leu Ala Leu Gly Gly Tyr Val Thr Lys Ser Gly Glu Lys Met Met 
                245                 250                 255     


Gly Leu Asn Asp Ala Leu Asn Leu Ala His Gln Ser Glu Lys Ser Ser 
            260                 265                 270         


Lys Gly Arg Ile His Met Thr Pro Leu Phe Lys Gln Ile Leu Ser Glu 
        275                 280                 285             


Lys Glu Ser Phe Ser Tyr Ile Pro Asp Val Phe Thr Glu Asp Ser Gln 
    290                 295                 300                 


Leu Leu Pro Ser Ile Gly Gly Phe Phe Ala Gln Ile Glu Asn Asp Lys 
305                 310                 315                 320 


Asp Gly Asn Ile Phe Asp Arg Ala Leu Glu Leu Ile Ser Ser Tyr Ala 
                325                 330                 335     


Glu Tyr Asp Thr Glu Arg Ile Tyr Ile Arg Gln Ala Asp Ile Asn Arg 
            340                 345                 350         


Val Ser Asn Val Ile Phe Gly Glu Trp Gly Thr Leu Gly Gly Leu Met 
        355                 360                 365             


Arg Glu Tyr Lys Ala Asp Ser Ile Asn Asp Ile Asn Leu Glu Arg Thr 
    370                 375                 380                 


Cys Lys Lys Val Asp Lys Trp Leu Asp Ser Lys Glu Phe Ala Leu Ser 
385                 390                 395                 400 


Asp Val Leu Glu Ala Ile Asp Arg Thr Gly Asn Asn Asp Ala Phe Asn 
                405                 410                 415     


Glu Tyr Ile Ser Lys Met Arg Thr Ala Arg Glu Lys Ile Asp Ala Ala 
            420                 425                 430         


Arg Lys Glu Met Lys Phe Ile Ser Glu Lys Ile Ser Gly Asp Glu Glu 
        435                 440                 445             


Ser Ile His Ile Ile Lys Thr Leu Leu Asp Ser Val Gln Gln Phe Leu 
    450                 455                 460                 


His Phe Phe Asn Leu Phe Lys Ala Arg Gln Asp Ile Pro Leu Asp Gly 
465                 470                 475                 480 


Ala Phe Tyr Ala Glu Phe Asp Glu Val His Ser Lys Leu Phe Ala Ile 
                485                 490                 495     


Val Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Lys Asn Asn Leu 
            500                 505                 510         


Asn Thr Lys Lys Ile Lys Leu Asn Phe Lys Asn Pro Thr Leu Ala Asn 
        515                 520                 525             


Gly Trp Asp Gln Asn Lys Val Tyr Asp Tyr Ala Ser Leu Ile Phe Leu 
    530                 535                 540                 


Arg Asp Gly Asn Tyr Tyr Leu Gly Ile Ile Asn Pro Lys Arg Lys Lys 
545                 550                 555                 560 


Asn Ile Lys Phe Glu Gln Gly Ser Gly Asn Gly Pro Phe Tyr Arg Lys 
                565                 570                 575     


Met Val Tyr Lys Gln Ile Pro Gly Pro Asn Lys Asn Leu Arg Pro Val 
            580                 585                 590         


Phe Leu Thr Ser Thr Lys Gly Lys Lys Glu Tyr Lys Pro Ser Lys Glu 
        595                 600                 605             


Ile Ile Glu Gly Tyr Glu Ala Asp Lys His Ile Arg Gly Asp Lys Phe 
    610                 615                 620                 


Asp Leu Asp Phe Cys His Lys Leu Ile Asp Phe Phe Lys Glu Ser Ile 
625                 630                 635                 640 


Glu Lys His Lys Asp Trp Ser Lys Phe Asn Phe Tyr Phe Ser Pro Thr 
                645                 650                 655     


Glu Ser Tyr Gly Asp Ile Ser Glu Phe Tyr Leu Asp Val Glu Lys Gln 
            660                 665                 670         


Gly Tyr Arg Met His Phe Glu Asn Ile Ser Ala Glu Thr Ile Asp Glu 
        675                 680                 685             


Tyr Val Glu Lys Gly Asp Leu Phe Leu Phe Gln Ile Tyr Asn Lys Asp 
    690                 695                 700                 


Phe Val Lys Ala Ala Thr Gly Lys Lys Asp Met His Thr Ile Tyr Trp 
705                 710                 715                 720 


Asn Ala Ala Phe Ser Pro Glu Asn Leu Gln Asp Val Val Val Lys Leu 
                725                 730                 735     


Asn Gly Glu Ala Glu Leu Phe Tyr Arg Asp Lys Ser Asp Ile Lys Glu 
            740                 745                 750         


Ile Val His Arg Glu Gly Glu Ile Leu Val Asn Arg Thr Tyr Asn Gly 
        755                 760                 765             


Arg Thr Pro Val Pro Asp Lys Ile His Lys Lys Leu Thr Asp Tyr His 
    770                 775                 780                 


Asn Gly Arg Thr Lys Asp Leu Gly Glu Ala Lys Glu Tyr Leu Asp Lys 
785                 790                 795                 800 


Val Arg Tyr Phe Lys Ala His Tyr Asp Ile Thr Lys Asp Arg Arg Tyr 
                805                 810                 815     


Leu Asn Asp Lys Ile Tyr Phe His Val Pro Leu Thr Leu Asn Phe Lys 
            820                 825                 830         


Ala Asn Gly Lys Lys Asn Leu Asn Lys Met Val Ile Glu Lys Phe Leu 
        835                 840                 845             


Ser Asp Glu Lys Ala His Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Tyr Ser Ile Ile Asp Arg Ser Gly Lys Ile Ile Asp Gln 
865                 870                 875                 880 


Gln Ser Leu Asn Val Ile Asp Gly Phe Asp Tyr Arg Glu Lys Leu Asn 
                885                 890                 895     


Gln Arg Glu Ile Glu Met Lys Asp Ala Arg Gln Ser Trp Asn Ala Ile 
            900                 905                 910         


Gly Lys Ile Lys Asp Leu Lys Glu Gly Tyr Leu Ser Lys Ala Val His 
        915                 920                 925             


Glu Ile Thr Lys Met Ala Ile Gln Tyr Asn Ala Ile Val Val Met Glu 
    930                 935                 940                 


Glu Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys Val Glu Lys Gln 
945                 950                 955                 960 


Ile Tyr Gln Lys Phe Glu Asn Met Leu Ile Asp Lys Met Asn Tyr Leu 
                965                 970                 975     


Val Phe Lys Asp Ala Pro Asp Glu Ser Pro Gly Gly Val Leu Asn Ala 
            980                 985                 990         


Tyr Gln Leu Thr Asn Pro Leu Glu  Ser Phe Ala Lys Leu  Gly Lys Gln 
        995                 1000                 1005             


Thr Gly  Ile Leu Phe Tyr Val  Pro Ala Ala Tyr Thr  Ser Lys Ile 
    1010                 1015                 1020             


Asp Pro  Thr Thr Gly Phe Val  Asn Leu Phe Asn Thr  Ser Ser Lys 
    1025                 1030                 1035             


Thr Asn  Ala Gln Glu Arg Lys  Glu Phe Leu Gln Lys  Phe Glu Ser 
    1040                 1045                 1050             


Ile Ser  Tyr Ser Ala Lys Asp  Gly Gly Ile Phe Ala  Phe Ala Phe 
    1055                 1060                 1065             


Asp Tyr  Arg Lys Phe Gly Thr  Ser Lys Thr Asp His  Lys Asn Val 
    1070                 1075                 1080             


Trp Thr  Ala Tyr Thr Asn Gly  Glu Arg Met Arg Tyr  Ile Lys Glu 
    1085                 1090                 1095             


Lys Lys  Arg Asn Glu Leu Phe  Asp Pro Ser Lys Glu  Ile Lys Glu 
    1100                 1105                 1110             


Ala Leu  Thr Ser Ser Gly Ile  Lys Tyr Asp Gly Gly  Gln Asn Ile 
    1115                 1120                 1125             


Leu Pro  Asp Ile Leu Arg Ser  Asn Asn Asn Gly Leu  Ile Tyr Thr 
    1130                 1135                 1140             


Met Tyr  Ser Ser Phe Ile Ala  Ala Ile Gln Met Arg  Val Tyr Asp 
    1145                 1150                 1155             


Gly Lys  Glu Asp Tyr Ile Ile  Ser Pro Ile Lys Asn  Ser Lys Gly 
    1160                 1165                 1170             


Glu Phe  Phe Arg Thr Asp Pro  Lys Arg Arg Glu Leu  Pro Ile Asp 
    1175                 1180                 1185             


Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala Leu Arg  Gly Glu Leu 
    1190                 1195                 1200             


Thr Met  Arg Ala Ile Ala Glu  Lys Phe Asp Pro Asp  Ser Glu Lys 
    1205                 1210                 1215             


Met Ala  Lys Leu Glu Leu Lys  His Lys Asp Trp Phe  Glu Phe Met 
    1220                 1225                 1230             


Gln Thr  Arg Gly Asp 
    1235             


<210>  5
<211>  1281
<212>  PRT
<213>  Eubacterium eligens

<400>  5

Met Asn Gly Asn Arg Ser Ile Val Tyr Arg Glu Phe Val Gly Val Ile 
1               5                   10                  15      


Pro Val Ala Lys Thr Leu Arg Asn Glu Leu Arg Pro Val Gly His Thr 
            20                  25                  30          


Gln Glu His Ile Ile Gln Asn Gly Leu Ile Gln Glu Asp Glu Leu Arg 
        35                  40                  45              


Gln Glu Lys Ser Thr Glu Leu Lys Asn Ile Met Asp Asp Tyr Tyr Arg 
    50                  55                  60                  


Glu Tyr Ile Asp Lys Ser Leu Ser Gly Val Thr Asp Leu Asp Phe Thr 
65                  70                  75                  80  


Leu Leu Phe Glu Leu Met Asn Leu Val Gln Ser Ser Pro Ser Lys Asp 
                85                  90                  95      


Asn Lys Lys Ala Leu Glu Lys Glu Gln Ser Lys Met Arg Glu Gln Ile 
            100                 105                 110         


Cys Thr His Leu Gln Ser Asp Ser Asn Tyr Lys Asn Ile Phe Asn Ala 
        115                 120                 125             


Lys Leu Leu Lys Glu Ile Leu Pro Asp Phe Ile Lys Asn Tyr Asn Gln 
    130                 135                 140                 


Tyr Asp Val Lys Asp Lys Ala Gly Lys Leu Glu Thr Leu Ala Leu Phe 
145                 150                 155                 160 


Asn Gly Phe Ser Thr Tyr Phe Thr Asp Phe Phe Glu Lys Arg Lys Asn 
                165                 170                 175     


Val Phe Thr Lys Glu Ala Val Ser Thr Ser Ile Ala Tyr Arg Ile Val 
            180                 185                 190         


His Glu Asn Ser Leu Ile Phe Leu Ala Asn Met Thr Ser Tyr Lys Lys 
        195                 200                 205             


Ile Ser Glu Lys Ala Leu Asp Glu Ile Glu Val Ile Glu Lys Asn Asn 
    210                 215                 220                 


Gln Asp Lys Met Gly Asp Trp Glu Leu Asn Gln Ile Phe Asn Pro Asp 
225                 230                 235                 240 


Phe Tyr Asn Met Val Leu Ile Gln Ser Gly Ile Asp Phe Tyr Asn Glu 
                245                 250                 255     


Ile Cys Gly Val Val Asn Ala His Met Asn Leu Tyr Cys Gln Gln Thr 
            260                 265                 270         


Lys Asn Asn Tyr Asn Leu Phe Lys Met Arg Lys Leu His Lys Gln Ile 
        275                 280                 285             


Leu Ala Tyr Thr Ser Thr Ser Phe Glu Val Pro Lys Met Phe Glu Asp 
    290                 295                 300                 


Asp Met Ser Val Tyr Asn Ala Val Asn Ala Phe Ile Asp Glu Thr Glu 
305                 310                 315                 320 


Lys Gly Asn Ile Ile Gly Lys Leu Lys Asp Ile Val Asn Lys Tyr Asp 
                325                 330                 335     


Glu Leu Asp Glu Lys Arg Ile Tyr Ile Ser Lys Asp Phe Tyr Glu Thr 
            340                 345                 350         


Leu Ser Cys Phe Met Ser Gly Asn Trp Asn Leu Ile Thr Gly Cys Val 
        355                 360                 365             


Glu Asn Phe Tyr Asp Glu Asn Ile His Ala Lys Gly Lys Ser Lys Glu 
    370                 375                 380                 


Glu Lys Val Lys Lys Ala Val Lys Glu Asp Lys Tyr Lys Ser Ile Asn 
385                 390                 395                 400 


Asp Val Asn Asp Leu Val Glu Lys Tyr Ile Asp Glu Lys Glu Arg Asn 
                405                 410                 415     


Glu Phe Lys Asn Ser Asn Ala Lys Gln Tyr Ile Arg Glu Ile Ser Asn 
            420                 425                 430         


Ile Ile Thr Asp Thr Glu Thr Ala His Leu Glu Tyr Asp Asp His Ile 
        435                 440                 445             


Ser Leu Ile Glu Ser Glu Glu Lys Ala Asp Glu Met Lys Lys Arg Leu 
    450                 455                 460                 


Asp Met Tyr Met Asn Met Tyr His Trp Ala Lys Ala Phe Ile Val Asp 
465                 470                 475                 480 


Glu Val Leu Asp Arg Asp Glu Met Phe Tyr Ser Asp Ile Asp Asp Ile 
                485                 490                 495     


Tyr Asn Ile Leu Glu Asn Ile Val Pro Leu Tyr Asn Arg Val Arg Asn 
            500                 505                 510         


Tyr Val Thr Gln Lys Pro Tyr Asn Ser Lys Lys Ile Lys Leu Asn Phe 
        515                 520                 525             


Gln Ser Pro Thr Leu Ala Asn Gly Trp Ser Gln Ser Lys Glu Phe Asp 
    530                 535                 540                 


Asn Asn Ala Ile Ile Leu Ile Arg Asp Asn Lys Tyr Tyr Leu Ala Ile 
545                 550                 555                 560 


Phe Asn Ala Lys Asn Lys Pro Asp Lys Lys Ile Ile Gln Gly Asn Ser 
                565                 570                 575     


Asp Lys Lys Asn Asp Asn Asp Tyr Lys Lys Met Val Tyr Asn Leu Leu 
            580                 585                 590         


Pro Gly Ala Asn Lys Met Leu Pro Lys Val Phe Leu Ser Lys Lys Gly 
        595                 600                 605             


Ile Glu Thr Phe Lys Pro Ser Asp Tyr Ile Ile Ser Gly Tyr Asn Ala 
    610                 615                 620                 


His Lys His Ile Lys Thr Ser Glu Asn Phe Asp Ile Ser Phe Cys Arg 
625                 630                 635                 640 


Asp Leu Ile Asp Tyr Phe Lys Asn Ser Ile Glu Lys His Ala Glu Trp 
                645                 650                 655     


Arg Lys Tyr Glu Phe Lys Phe Ser Ala Thr Asp Ser Tyr Ser Asp Ile 
            660                 665                 670         


Ser Glu Phe Tyr Arg Glu Val Glu Met Gln Gly Tyr Arg Ile Asp Trp 
        675                 680                 685             


Thr Tyr Ile Ser Glu Ala Asp Ile Asn Lys Leu Asp Glu Glu Gly Lys 
    690                 695                 700                 


Ile Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Glu Asn Ser Thr 
705                 710                 715                 720 


Gly Lys Glu Asn Leu His Thr Met Tyr Phe Lys Asn Ile Phe Ser Glu 
                725                 730                 735     


Glu Asn Leu Asp Lys Ile Ile Lys Leu Asn Gly Gln Ala Glu Leu Phe 
            740                 745                 750         


Tyr Arg Arg Ala Ser Val Lys Asn Pro Val Lys His Lys Lys Asp Ser 
        755                 760                 765             


Val Leu Val Asn Lys Thr Tyr Lys Asn Gln Leu Asp Asn Gly Asp Val 
    770                 775                 780                 


Val Arg Ile Pro Ile Pro Asp Asp Ile Tyr Asn Glu Ile Tyr Lys Met 
785                 790                 795                 800 


Tyr Asn Gly Tyr Ile Lys Glu Ser Asp Leu Ser Glu Ala Ala Lys Glu 
                805                 810                 815     


Tyr Leu Asp Lys Val Glu Val Arg Thr Ala Gln Lys Asp Ile Val Lys 
            820                 825                 830         


Asp Tyr Arg Tyr Thr Val Asp Lys Tyr Phe Ile His Thr Pro Ile Thr 
        835                 840                 845             


Ile Asn Tyr Lys Val Thr Ala Arg Asn Asn Val Asn Asp Met Val Val 
    850                 855                 860                 


Lys Tyr Ile Ala Gln Asn Asp Asp Ile His Val Ile Gly Ile Asp Arg 
865                 870                 875                 880 


Gly Glu Arg Asn Leu Ile Tyr Ile Ser Val Ile Asp Ser His Gly Asn 
                885                 890                 895     


Ile Val Lys Gln Lys Ser Tyr Asn Ile Leu Asn Asn Tyr Asp Tyr Lys 
            900                 905                 910         


Lys Lys Leu Val Glu Lys Glu Lys Thr Arg Glu Tyr Ala Arg Lys Asn 
        915                 920                 925             


Trp Lys Ser Ile Gly Asn Ile Lys Glu Leu Lys Glu Gly Tyr Ile Ser 
    930                 935                 940                 


Gly Val Val His Glu Ile Ala Met Leu Ile Val Glu Tyr Asn Ala Ile 
945                 950                 955                 960 


Ile Ala Met Glu Asp Leu Asn Tyr Gly Phe Lys Arg Gly Arg Phe Lys 
                965                 970                 975     


Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Ser Met Leu Ile Asn Lys 
            980                 985                 990         


Leu Asn Tyr Phe Ala Ser Lys Glu  Lys Ser Val Asp Glu  Pro Gly Gly 
        995                 1000                 1005             


Leu Leu  Lys Gly Tyr Gln Leu  Thr Tyr Val Pro Asp  Asn Ile Lys 
    1010                 1015                 1020             


Asn Leu  Gly Lys Gln Cys Gly  Val Ile Phe Tyr Val  Pro Ala Ala 
    1025                 1030                 1035             


Phe Thr  Ser Lys Ile Asp Pro  Ser Thr Gly Phe Ile  Ser Ala Phe 
    1040                 1045                 1050             


Asn Phe  Lys Ser Ile Ser Thr  Asn Ala Ser Arg Lys  Gln Phe Phe 
    1055                 1060                 1065             


Met Gln  Phe Asp Glu Ile Arg  Tyr Cys Ala Glu Lys  Asp Met Phe 
    1070                 1075                 1080             


Ser Phe  Gly Phe Asp Tyr Asn  Asn Phe Asp Thr Tyr  Asn Ile Thr 
    1085                 1090                 1095             


Met Gly  Lys Thr Gln Trp Thr  Val Tyr Thr Asn Gly  Glu Arg Leu 
    1100                 1105                 1110             


Gln Ser  Glu Phe Asn Asn Ala  Arg Arg Thr Gly Lys  Thr Lys Ser 
    1115                 1120                 1125             


Ile Asn  Leu Thr Glu Thr Ile  Lys Leu Leu Leu Glu  Asp Asn Glu 
    1130                 1135                 1140             


Ile Asn  Tyr Ala Asp Gly His  Asp Ile Arg Ile Asp  Met Glu Lys 
    1145                 1150                 1155             


Met Asp  Glu Asp Lys Lys Ser  Glu Phe Phe Ala Gln  Leu Leu Ser 
    1160                 1165                 1170             


Leu Tyr  Lys Leu Thr Val Gln  Met Arg Asn Ser Tyr  Thr Glu Ala 
    1175                 1180                 1185             


Glu Glu  Gln Glu Asn Gly Ile  Ser Tyr Asp Lys Ile  Ile Ser Pro 
    1190                 1195                 1200             


Val Ile  Asn Asp Glu Gly Glu  Phe Phe Asp Ser Asp  Asn Tyr Lys 
    1205                 1210                 1215             


Glu Ser  Asp Asp Lys Glu Cys  Lys Met Pro Lys Asp  Ala Asp Ala 
    1220                 1225                 1230             


Asn Gly  Ala Tyr Cys Ile Ala  Leu Lys Gly Leu Tyr  Glu Val Leu 
    1235                 1240                 1245             


Lys Ile  Lys Ser Glu Trp Thr  Glu Asp Gly Phe Asp  Arg Asn Cys 
    1250                 1255                 1260             


Leu Lys  Leu Pro His Ala Glu  Trp Leu Asp Phe Ile  Gln Asn Lys 
    1265                 1270                 1275             


Arg Tyr  Glu 
    1280     


<210>  6
<211>  1300
<212>  PRT
<213>  Francisella novicida

<400>  6

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Val Asn Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  7
<211>  1206
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  7

Met Tyr Tyr Glu Ser Leu Thr Lys Gln Tyr Pro Val Ser Lys Thr Ile 
1               5                   10                  15      


Arg Asn Glu Leu Ile Pro Ile Gly Lys Thr Leu Asp Asn Ile Arg Gln 
            20                  25                  30          


Asn Asn Ile Leu Glu Ser Asp Val Lys Arg Lys Gln Asn Tyr Glu His 
        35                  40                  45              


Val Lys Gly Ile Leu Asp Glu Tyr His Lys Gln Leu Ile Asn Glu Ala 
    50                  55                  60                  


Leu Asp Asn Cys Thr Leu Pro Ser Leu Lys Ile Ala Ala Glu Ile Tyr 
65                  70                  75                  80  


Leu Lys Asn Gln Lys Glu Val Ser Asp Arg Glu Asp Phe Asn Lys Thr 
                85                  90                  95      


Gln Asp Leu Leu Arg Lys Glu Val Val Glu Lys Leu Lys Ala His Glu 
            100                 105                 110         


Asn Phe Thr Lys Ile Gly Lys Lys Asp Ile Leu Asp Leu Leu Glu Lys 
        115                 120                 125             


Leu Pro Ser Ile Ser Glu Asp Asp Tyr Asn Ala Leu Glu Ser Phe Arg 
    130                 135                 140                 


Asn Phe Tyr Thr Tyr Phe Thr Ser Tyr Asn Lys Val Arg Glu Asn Leu 
145                 150                 155                 160 


Tyr Ser Asp Lys Glu Lys Ser Ser Thr Val Ala Tyr Arg Leu Ile Asn 
                165                 170                 175     


Glu Asn Phe Pro Lys Phe Leu Asp Asn Val Lys Ser Tyr Arg Phe Val 
            180                 185                 190         


Lys Thr Ala Gly Ile Leu Ala Asp Gly Leu Gly Glu Glu Glu Gln Asp 
        195                 200                 205             


Ser Leu Phe Ile Val Glu Thr Phe Asn Lys Thr Leu Thr Gln Asp Gly 
    210                 215                 220                 


Ile Asp Thr Tyr Asn Ser Gln Val Gly Lys Ile Asn Ser Ser Ile Asn 
225                 230                 235                 240 


Leu Tyr Asn Gln Lys Asn Gln Lys Ala Asn Gly Phe Arg Lys Ile Pro 
                245                 250                 255     


Lys Met Lys Met Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Glu Ser 
            260                 265                 270         


Phe Ile Asp Glu Phe Gln Ser Asp Glu Val Leu Ile Asp Asn Val Glu 
        275                 280                 285             


Ser Tyr Gly Ser Val Leu Ile Glu Ser Leu Lys Ser Ser Lys Val Ser 
    290                 295                 300                 


Ala Phe Phe Asp Ala Leu Arg Glu Ser Lys Gly Lys Asn Val Tyr Val 
305                 310                 315                 320 


Lys Asn Asp Leu Ala Lys Thr Ala Met Ser Val Ile Val Phe Glu Asn 
                325                 330                 335     


Trp Arg Thr Phe Asp Asp Leu Leu Asn Gln Glu Tyr Asp Leu Ala Asn 
            340                 345                 350         


Glu Asn Lys Lys Lys Asp Asp Lys Tyr Phe Glu Lys Arg Gln Lys Glu 
        355                 360                 365             


Leu Lys Lys Asn Lys Ser Tyr Ser Leu Glu His Leu Cys Asn Leu Ser 
    370                 375                 380                 


Glu Asp Ser Cys Asn Leu Ile Glu Asn Tyr Ile His Gln Ile Ser Asp 
385                 390                 395                 400 


Asp Ile Glu Asn Ile Ile Ile Asn Asn Glu Thr Phe Leu Arg Ile Val 
                405                 410                 415     


Ile Asn Glu His Asp Arg Ser Arg Lys Leu Ala Lys Asn Arg Lys Ala 
            420                 425                 430         


Val Lys Ala Ile Lys Asp Phe Leu Asp Ser Ile Lys Val Leu Glu Arg 
        435                 440                 445             


Glu Leu Lys Leu Ile Asn Ser Ser Gly Gln Glu Leu Glu Lys Asp Leu 
    450                 455                 460                 


Ile Val Tyr Ser Ala His Glu Glu Leu Leu Val Glu Leu Lys Gln Val 
465                 470                 475                 480 


Asp Ser Leu Tyr Asn Met Thr Arg Asn Tyr Leu Thr Lys Lys Pro Phe 
                485                 490                 495     


Ser Thr Glu Lys Val Lys Leu Asn Phe Asn Arg Ser Thr Leu Leu Asn 
            500                 505                 510         


Gly Trp Asp Arg Asn Lys Glu Thr Asp Asn Leu Gly Val Leu Leu Leu 
        515                 520                 525             


Lys Asp Gly Lys Tyr Tyr Leu Gly Ile Met Asn Thr Ser Ala Asn Lys 
    530                 535                 540                 


Ala Phe Val Asn Pro Pro Val Ala Lys Thr Glu Lys Val Phe Lys Lys 
545                 550                 555                 560 


Val Asp Tyr Lys Leu Leu Pro Val Pro Asn Gln Met Leu Pro Lys Val 
                565                 570                 575     


Phe Phe Ala Lys Ser Asn Ile Asp Phe Tyr Asn Pro Ser Ser Glu Ile 
            580                 585                 590         


Tyr Ser Asn Tyr Lys Lys Gly Thr His Lys Lys Gly Asn Met Phe Ser 
        595                 600                 605             


Leu Glu Asp Cys His Asn Leu Ile Asp Phe Phe Lys Glu Ser Ile Ser 
    610                 615                 620                 


Lys His Glu Asp Trp Ser Lys Phe Gly Phe Lys Phe Asp Thr Gln Ala 
625                 630                 635                 640 


Ser Tyr Asn Asp Ile Ser Glu Phe Tyr Arg Glu Val Glu Lys Gln Gly 
                645                 650                 655     


Tyr Lys Leu Thr Tyr Thr Asp Ile Asp Glu Thr Tyr Ile Asn Asp Leu 
            660                 665                 670         


Ile Glu Arg Asn Glu Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
        675                 680                 685             


Ser Met Tyr Ser Lys Gly Lys Leu Asn Leu His Thr Leu Tyr Phe Met 
    690                 695                 700                 


Met Leu Phe Asp Gln Arg Asn Ile Asp Asp Val Val Tyr Lys Leu Asn 
705                 710                 715                 720 


Gly Glu Ala Glu Val Phe Tyr Arg Pro Ala Ser Ile Ser Glu Asp Glu 
                725                 730                 735     


Leu Ile Ile His Lys Ala Gly Glu Glu Ile Lys Asn Lys Asn Pro Asn 
            740                 745                 750         


Arg Ala Arg Thr Lys Glu Thr Ser Thr Phe Ser Tyr Asp Ile Val Lys 
        755                 760                 765             


Asp Lys Arg Tyr Ser Lys Asp Lys Phe Thr Leu His Ile Pro Ile Thr 
    770                 775                 780                 


Met Asn Phe Gly Val Asp Glu Val Lys Arg Phe Asn Asp Ala Val Asn 
785                 790                 795                 800 


Ser Ala Ile Arg Ile Asp Glu Asn Val Asn Val Ile Gly Ile Asp Arg 
                805                 810                 815     


Gly Glu Arg Asn Leu Leu Tyr Val Val Val Ile Asp Ser Lys Gly Asn 
            820                 825                 830         


Ile Leu Glu Gln Ile Ser Leu Asn Ser Ile Ile Asn Lys Glu Tyr Asp 
        835                 840                 845             


Ile Glu Thr Asp Tyr His Ala Leu Leu Asp Glu Arg Glu Gly Gly Arg 
    850                 855                 860                 


Asp Lys Ala Arg Lys Asp Trp Asn Thr Val Glu Asn Ile Arg Asp Leu 
865                 870                 875                 880 


Lys Ala Gly Leu Tyr Leu Gln Val Val Asn Val Val Ala Lys Leu Val 
                885                 890                 895     


Leu Lys Tyr Asn Ala Ile Ile Cys Leu Glu Asp Leu Asn Phe Gly Phe 
            900                 905                 910         


Lys Arg Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu 
        915                 920                 925             


Lys Met Leu Ile Asp Lys Leu Asn Tyr Leu Val Ile Asp Lys Ser Arg 
    930                 935                 940                 


Glu Gln Thr Ser Pro Lys Glu Leu Gly Gly Ala Leu Asn Ala Leu Gln 
945                 950                 955                 960 


Leu Thr Ser Lys Phe Lys Ser Phe Lys Glu Leu Gly Lys Gln Ser Gly 
                965                 970                 975     


Val Ile Tyr Tyr Val Pro Ala Tyr Leu Thr Ser Lys Ile Asp Pro Thr 
            980                 985                 990         


Thr Gly Phe Ala Asn Leu Phe Tyr  Met Lys Cys Glu Asn  Val Glu Lys 
        995                 1000                 1005             


Ser Lys  Arg Phe Phe Asp Gly  Phe Asp Phe Ile Arg  Phe Asn Ala 
    1010                 1015                 1020             


Leu Glu  Asn Val Phe Glu Phe  Gly Phe Asp Tyr Arg  Ser Phe Thr 
    1025                 1030                 1035             


Gln Arg  Ala Cys Gly Ile Asn  Ser Lys Trp Thr Val  Cys Thr Asn 
    1040                 1045                 1050             


Gly Glu  Arg Ile Ile Lys Tyr  Arg Asn Pro Asp Lys  Asn Asn Met 
    1055                 1060                 1065             


Phe Asp  Glu Lys Val Val Val  Val Thr Asp Glu Met  Lys Asn Leu 
    1070                 1075                 1080             


Phe Glu  Gln Tyr Lys Ile Pro  Tyr Glu Asp Gly Arg  Asn Val Lys 
    1085                 1090                 1095             


Asp Met  Ile Ile Ser Asn Glu  Glu Ala Glu Phe Tyr  Arg Arg Leu 
    1100                 1105                 1110             


Tyr Arg  Leu Leu Gln Gln Thr  Leu Gln Met Arg Asn  Ser Thr Ser 
    1115                 1120                 1125             


Asp Gly  Thr Arg Asp Tyr Ile  Ile Ser Pro Val Lys  Asn Lys Arg 
    1130                 1135                 1140             


Glu Ala  Tyr Phe Asn Ser Glu  Leu Ser Asp Gly Ser  Val Pro Lys 
    1145                 1150                 1155             


Asp Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Leu 
    1160                 1165                 1170             


Trp Val  Leu Glu Gln Ile Arg  Gln Lys Ser Glu Gly  Glu Lys Ile 
    1175                 1180                 1185             


Asn Leu  Ala Met Thr Asn Ala  Glu Trp Leu Glu Tyr  Ala Gln Thr 
    1190                 1195                 1200             


His Leu  Leu 
    1205     


<210>  8
<211>  1233
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  8

Met Asp Tyr Gly Asn Gly Gln Phe Glu Arg Arg Ala Pro Leu Thr Lys 
1               5                   10                  15      


Thr Ile Thr Leu Arg Leu Lys Pro Ile Gly Glu Thr Arg Glu Thr Ile 
            20                  25                  30          


Arg Glu Gln Lys Leu Leu Glu Gln Asp Ala Ala Phe Arg Lys Leu Val 
        35                  40                  45              


Glu Thr Val Thr Pro Ile Val Asp Asp Cys Ile Arg Lys Ile Ala Asp 
    50                  55                  60                  


Asn Ala Leu Cys His Phe Gly Thr Glu Tyr Asp Phe Ser Cys Leu Gly 
65                  70                  75                  80  


Asn Ala Ile Ser Lys Asn Asp Ser Lys Ala Ile Lys Lys Glu Thr Glu 
                85                  90                  95      


Lys Val Glu Lys Leu Leu Ala Lys Val Leu Thr Glu Asn Leu Pro Asp 
            100                 105                 110         


Gly Leu Arg Lys Val Asn Asp Ile Asn Ser Ala Ala Phe Ile Gln Asp 
        115                 120                 125             


Thr Leu Thr Ser Phe Val Gln Asp Asp Ala Asp Lys Arg Val Leu Ile 
    130                 135                 140                 


Gln Glu Leu Lys Gly Lys Thr Val Leu Met Gln Arg Phe Leu Thr Thr 
145                 150                 155                 160 


Arg Ile Thr Ala Leu Thr Val Trp Leu Pro Asp Arg Val Phe Glu Asn 
                165                 170                 175     


Phe Asn Ile Phe Ile Glu Asn Ala Glu Lys Met Arg Ile Leu Leu Asp 
            180                 185                 190         


Ser Pro Leu Asn Glu Lys Ile Met Lys Phe Asp Pro Asp Ala Glu Gln 
        195                 200                 205             


Tyr Ala Ser Leu Glu Phe Tyr Gly Gln Cys Leu Ser Gln Lys Asp Ile 
    210                 215                 220                 


Asp Ser Tyr Asn Leu Ile Ile Ser Gly Ile Tyr Ala Asp Asp Glu Val 
225                 230                 235                 240 


Lys Asn Pro Gly Ile Asn Glu Ile Val Lys Glu Tyr Asn Gln Gln Ile 
                245                 250                 255     


Arg Gly Asp Lys Asp Glu Ser Pro Leu Pro Lys Leu Lys Lys Leu His 
            260                 265                 270         


Lys Gln Ile Leu Met Pro Val Glu Lys Ala Phe Phe Val Arg Val Leu 
        275                 280                 285             


Ser Asn Asp Ser Asp Ala Arg Ser Ile Leu Glu Lys Ile Leu Lys Asp 
    290                 295                 300                 


Thr Glu Met Leu Pro Ser Lys Ile Ile Glu Ala Met Lys Glu Ala Asp 
305                 310                 315                 320 


Ala Gly Asp Ile Ala Val Tyr Gly Ser Arg Leu His Glu Leu Ser His 
                325                 330                 335     


Val Ile Tyr Gly Asp His Gly Lys Leu Ser Gln Ile Ile Tyr Asp Lys 
            340                 345                 350         


Glu Ser Lys Arg Ile Ser Glu Leu Met Glu Thr Leu Ser Pro Lys Glu 
        355                 360                 365             


Arg Lys Glu Ser Lys Lys Arg Leu Glu Gly Leu Glu Glu His Ile Arg 
    370                 375                 380                 


Lys Ser Thr Tyr Thr Phe Asp Glu Leu Asn Arg Tyr Ala Glu Lys Asn 
385                 390                 395                 400 


Val Met Ala Ala Tyr Ile Ala Ala Val Glu Glu Ser Cys Ala Glu Ile 
                405                 410                 415     


Met Arg Lys Glu Lys Asp Leu Arg Thr Leu Leu Ser Lys Glu Asp Val 
            420                 425                 430         


Lys Ile Arg Gly Asn Arg His Asn Thr Leu Ile Val Lys Asn Tyr Phe 
        435                 440                 445             


Asn Ala Trp Thr Val Phe Arg Asn Leu Ile Arg Ile Leu Arg Arg Lys 
    450                 455                 460                 


Ser Glu Ala Glu Ile Asp Ser Asp Phe Tyr Asp Val Leu Asp Asp Ser 
465                 470                 475                 480 


Val Glu Val Leu Ser Leu Thr Tyr Lys Gly Glu Asn Leu Cys Arg Ser 
                485                 490                 495     


Tyr Ile Thr Lys Lys Ile Gly Ser Asp Leu Lys Pro Glu Ile Ala Thr 
            500                 505                 510         


Tyr Gly Ser Ala Leu Arg Pro Asn Ser Arg Trp Trp Ser Pro Gly Glu 
        515                 520                 525             


Lys Phe Asn Val Lys Phe His Thr Ile Val Arg Arg Asp Gly Arg Leu 
    530                 535                 540                 


Tyr Tyr Phe Ile Leu Pro Lys Gly Ala Lys Pro Val Glu Leu Glu Asp 
545                 550                 555                 560 


Met Asp Gly Asp Ile Glu Cys Leu Gln Met Arg Lys Ile Pro Asn Pro 
                565                 570                 575     


Thr Ile Phe Leu Pro Lys Leu Val Phe Lys Asp Pro Glu Ala Phe Phe 
            580                 585                 590         


Arg Asp Asn Pro Glu Ala Asp Glu Phe Val Phe Leu Ser Gly Met Lys 
        595                 600                 605             


Ala Pro Val Thr Ile Thr Arg Glu Thr Tyr Glu Ala Tyr Arg Tyr Lys 
    610                 615                 620                 


Leu Tyr Thr Val Gly Lys Leu Arg Asp Gly Glu Val Ser Glu Glu Glu 
625                 630                 635                 640 


Tyr Lys Arg Ala Leu Leu Gln Val Leu Thr Ala Tyr Lys Glu Phe Leu 
                645                 650                 655     


Glu Asn Arg Met Ile Tyr Ala Asp Leu Asn Phe Gly Phe Lys Asp Leu 
            660                 665                 670         


Glu Glu Tyr Lys Asp Ser Ser Glu Phe Ile Lys Gln Val Glu Thr His 
        675                 680                 685             


Asn Thr Phe Met Cys Trp Ala Lys Val Ser Ser Ser Gln Leu Asp Asp 
    690                 695                 700                 


Leu Val Lys Ser Gly Asn Gly Leu Leu Phe Glu Ile Trp Ser Glu Arg 
705                 710                 715                 720 


Leu Glu Ser Tyr Tyr Lys Tyr Gly Asn Glu Lys Val Leu Arg Gly Tyr 
                725                 730                 735     


Glu Gly Val Leu Leu Ser Ile Leu Lys Asp Glu Asn Leu Val Ser Met 
            740                 745                 750         


Arg Thr Leu Leu Asn Ser Arg Pro Met Leu Val Tyr Arg Pro Lys Glu 
        755                 760                 765             


Ser Ser Lys Pro Met Val Val His Arg Asp Gly Ser Arg Val Val Asp 
    770                 775                 780                 


Arg Phe Asp Lys Asp Gly Lys Tyr Ile Pro Pro Glu Val His Asp Glu 
785                 790                 795                 800 


Leu Tyr Arg Phe Phe Asn Asn Leu Leu Ile Lys Glu Lys Leu Gly Glu 
                805                 810                 815     


Lys Ala Arg Lys Ile Leu Asp Asn Lys Lys Val Lys Val Lys Val Leu 
            820                 825                 830         


Glu Ser Glu Arg Val Lys Trp Ser Lys Phe Tyr Asp Glu Gln Phe Ala 
        835                 840                 845             


Val Thr Phe Ser Val Lys Lys Asn Ala Asp Cys Leu Asp Thr Thr Lys 
    850                 855                 860                 


Asp Leu Asn Ala Glu Val Met Glu Gln Tyr Ser Glu Ser Asn Arg Leu 
865                 870                 875                 880 


Ile Leu Ile Arg Asn Thr Thr Asp Ile Leu Tyr Tyr Leu Val Leu Asp 
                885                 890                 895     


Lys Asn Gly Lys Val Leu Lys Gln Arg Ser Leu Asn Ile Ile Asn Asp 
            900                 905                 910         


Gly Ala Arg Asp Val Asp Trp Lys Glu Arg Phe Arg Gln Val Thr Lys 
        915                 920                 925             


Asp Arg Asn Glu Gly Tyr Asn Glu Trp Asp Tyr Ser Arg Thr Ser Asn 
    930                 935                 940                 


Asp Leu Lys Glu Val Tyr Leu Asn Tyr Ala Leu Lys Glu Ile Ala Glu 
945                 950                 955                 960 


Ala Val Ile Glu Tyr Asn Ala Ile Leu Ile Ile Glu Lys Met Ser Asn 
                965                 970                 975     


Ala Phe Lys Asp Lys Tyr Ser Phe Leu Asp Asp Val Thr Phe Lys Gly 
            980                 985                 990         


Phe Glu Thr Lys Lys Leu Ala Lys  Leu Ser Asp Leu His  Phe Arg Gly 
        995                 1000                 1005             


Ile Lys  Asp Gly Glu Pro Cys  Ser Phe Thr Asn Pro  Leu Gln Leu 
    1010                 1015                 1020             


Cys Gln  Asn Asp Ser Asn Lys  Ile Leu Gln Asp Gly  Val Ile Phe 
    1025                 1030                 1035             


Met Val  Pro Asn Ser Met Thr  Arg Ser Leu Asp Pro  Asp Thr Gly 
    1040                 1045                 1050             


Phe Ile  Phe Ala Ile Asn Asp  His Asn Ile Arg Thr  Lys Lys Ala 
    1055                 1060                 1065             


Lys Leu  Asn Phe Leu Ser Lys  Phe Asp Gln Leu Lys  Val Ser Ser 
    1070                 1075                 1080             


Glu Gly  Cys Leu Ile Met Lys  Tyr Ser Gly Asp Ser  Leu Pro Thr 
    1085                 1090                 1095             


His Asn  Thr Asp Asn Arg Val  Trp Asn Cys Cys Cys  Asn His Pro 
    1100                 1105                 1110             


Ile Thr  Asn Tyr Asp Arg Glu  Thr Lys Lys Val Glu  Phe Ile Glu 
    1115                 1120                 1125             


Glu Pro  Val Glu Glu Leu Ser  Arg Val Leu Glu Glu  Asn Gly Ile 
    1130                 1135                 1140             


Glu Thr  Asp Thr Glu Leu Asn  Lys Leu Asn Glu Arg  Glu Asn Val 
    1145                 1150                 1155             


Pro Gly  Lys Val Val Asp Ala  Ile Tyr Ser Leu Val  Leu Asn Tyr 
    1160                 1165                 1170             


Leu Arg  Gly Thr Val Ser Gly  Val Ala Gly Gln Arg  Ala Val Tyr 
    1175                 1180                 1185             


Tyr Ser  Pro Val Thr Gly Lys  Lys Tyr Asp Ile Ser  Phe Ile Gln 
    1190                 1195                 1200             


Ala Met  Asn Leu Asn Arg Lys  Cys Asp Tyr Tyr Arg  Ile Gly Ser 
    1205                 1210                 1215             


Lys Glu  Arg Gly Glu Trp Thr  Asp Phe Val Ala Gln  Leu Ile Asn 
    1220                 1225                 1230             


<210>  9
<211>  1227
<212>  PRT
<213>  Unknown

<220>
<223>  Lachnospiraceae bacterium

<400>  9

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Asn Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu 
                805                 810                 815     


Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile 
            820                 825                 830         


Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys 
        835                 840                 845             


Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe 
    850                 855                 860                 


Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys 
865                 870                 875                 880 


Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn 
                885                 890                 895     


Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile 
            900                 905                 910         


Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu 
        915                 920                 925             


Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr 
    930                 935                 940                 


Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp 
945                 950                 955                 960 


Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln 
                965                 970                 975     


Ile Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly 
            980                 985                 990         


Phe Ile Phe Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
        995                 1000                 1005             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1010                 1015                 1020             


Asp Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ser Asn Lys  Glu Trp Leu 
    1205                 1210                 1215             


Glu Tyr  Ala Gln Thr Ser Val  Lys His 
    1220                 1225         


<210>  10
<211>  1264
<212>  PRT
<213>  Leptospira inadai

<400>  10

Met Glu Asp Tyr Ser Gly Phe Val Asn Ile Tyr Ser Ile Gln Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu His Ile Glu 
            20                  25                  30          


Lys Lys Gly Phe Leu Lys Lys Asp Lys Ile Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Ala Val Lys Lys Ile Ile Asp Lys Tyr His Arg Ala Tyr Ile Glu Glu 
    50                  55                  60                  


Val Phe Asp Ser Val Leu His Gln Lys Lys Lys Lys Asp Lys Thr Arg 
65                  70                  75                  80  


Phe Ser Thr Gln Phe Ile Lys Glu Ile Lys Glu Phe Ser Glu Leu Tyr 
                85                  90                  95      


Tyr Lys Thr Glu Lys Asn Ile Pro Asp Lys Glu Arg Leu Glu Ala Leu 
            100                 105                 110         


Ser Glu Lys Leu Arg Lys Met Leu Val Gly Ala Phe Lys Gly Glu Phe 
        115                 120                 125             


Ser Glu Glu Val Ala Glu Lys Tyr Asn Lys Asn Leu Phe Ser Lys Glu 
    130                 135                 140                 


Leu Ile Arg Asn Glu Ile Glu Lys Phe Cys Glu Thr Asp Glu Glu Arg 
145                 150                 155                 160 


Lys Gln Val Ser Asn Phe Lys Ser Phe Thr Thr Tyr Phe Thr Gly Phe 
                165                 170                 175     


His Ser Asn Arg Gln Asn Ile Tyr Ser Asp Glu Lys Lys Ser Thr Ala 
            180                 185                 190         


Ile Gly Tyr Arg Ile Ile His Gln Asn Leu Pro Lys Phe Leu Asp Asn 
        195                 200                 205             


Leu Lys Ile Ile Glu Ser Ile Gln Arg Arg Phe Lys Asp Phe Pro Trp 
    210                 215                 220                 


Ser Asp Leu Lys Lys Asn Leu Lys Lys Ile Asp Lys Asn Ile Lys Leu 
225                 230                 235                 240 


Thr Glu Tyr Phe Ser Ile Asp Gly Phe Val Asn Val Leu Asn Gln Lys 
                245                 250                 255     


Gly Ile Asp Ala Tyr Asn Thr Ile Leu Gly Gly Lys Ser Glu Glu Ser 
            260                 265                 270         


Gly Glu Lys Ile Gln Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Arg Gln 
        275                 280                 285             


Lys Asn Asn Ile Asp Arg Lys Asn Pro Leu Asn Val Lys Ile Leu Phe 
    290                 295                 300                 


Lys Gln Ile Leu Gly Asp Arg Glu Thr Lys Ser Phe Ile Pro Glu Ala 
305                 310                 315                 320 


Phe Pro Asp Asp Gln Ser Val Leu Asn Ser Ile Thr Glu Phe Ala Lys 
                325                 330                 335     


Tyr Leu Lys Leu Asp Lys Lys Lys Lys Ser Ile Ile Ala Glu Leu Lys 
            340                 345                 350         


Lys Phe Leu Ser Ser Phe Asn Arg Tyr Glu Leu Asp Gly Ile Tyr Leu 
        355                 360                 365             


Ala Asn Asp Asn Ser Leu Ala Ser Ile Ser Thr Phe Leu Phe Asp Asp 
    370                 375                 380                 


Trp Ser Phe Ile Lys Lys Ser Val Ser Phe Lys Tyr Asp Glu Ser Val 
385                 390                 395                 400 


Gly Asp Pro Lys Lys Lys Ile Lys Ser Pro Leu Lys Tyr Glu Lys Glu 
                405                 410                 415     


Lys Glu Lys Trp Leu Lys Gln Lys Tyr Tyr Thr Ile Ser Phe Leu Asn 
            420                 425                 430         


Asp Ala Ile Glu Ser Tyr Ser Lys Ser Gln Asp Glu Lys Arg Val Lys 
        435                 440                 445             


Ile Arg Leu Glu Ala Tyr Phe Ala Glu Phe Lys Ser Lys Asp Asp Ala 
    450                 455                 460                 


Lys Lys Gln Phe Asp Leu Leu Glu Arg Ile Glu Glu Ala Tyr Ala Ile 
465                 470                 475                 480 


Val Glu Pro Leu Leu Gly Ala Glu Tyr Pro Arg Asp Arg Asn Leu Lys 
                485                 490                 495     


Ala Asp Lys Lys Glu Val Gly Lys Ile Lys Asp Phe Leu Asp Ser Ile 
            500                 505                 510         


Lys Ser Leu Gln Phe Phe Leu Lys Pro Leu Leu Ser Ala Glu Ile Phe 
        515                 520                 525             


Asp Glu Lys Asp Leu Gly Phe Tyr Asn Gln Leu Glu Gly Tyr Tyr Glu 
    530                 535                 540                 


Glu Ile Asp Ile Ser Gly His Leu Tyr Asn Lys Val Arg Asn Tyr Leu 
545                 550                 555                 560 


Thr Gly Lys Ile Tyr Ser Lys Glu Lys Phe Lys Leu Asn Phe Glu Asn 
                565                 570                 575     


Ser Thr Leu Leu Lys Gly Trp Asp Glu Asn Arg Glu Val Ala Asn Leu 
            580                 585                 590         


Cys Val Ile Phe Arg Glu Asp Gln Lys Tyr Tyr Leu Gly Val Met Asp 
        595                 600                 605             


Lys Glu Asn Asn Thr Ile Leu Ser Asp Ile Pro Lys Val Lys Pro Asn 
    610                 615                 620                 


Glu Leu Phe Tyr Glu Lys Met Val Tyr Lys Leu Ile Pro Thr Pro His 
625                 630                 635                 640 


Met Gln Leu Pro Arg Ile Ile Phe Ser Ser Asp Asn Leu Ser Ile Tyr 
                645                 650                 655     


Asn Pro Ser Lys Ser Ile Leu Lys Ile Arg Glu Ala Lys Ser Phe Lys 
            660                 665                 670         


Glu Gly Lys Asn Phe Lys Leu Lys Asp Cys His Lys Phe Ile Asp Phe 
        675                 680                 685             


Tyr Lys Glu Ser Ile Ser Lys Asn Glu Asp Trp Ser Arg Phe Asp Phe 
    690                 695                 700                 


Lys Phe Ser Lys Thr Ser Ser Tyr Glu Asn Ile Ser Glu Phe Tyr Arg 
705                 710                 715                 720 


Glu Val Glu Arg Gln Gly Tyr Asn Leu Asp Phe Lys Lys Val Ser Lys 
                725                 730                 735     


Phe Tyr Ile Asp Ser Leu Val Glu Asp Gly Lys Leu Tyr Leu Phe Gln 
            740                 745                 750         


Ile Tyr Asn Lys Asp Phe Ser Ile Phe Ser Lys Gly Lys Pro Asn Leu 
        755                 760                 765             


His Thr Ile Tyr Phe Arg Ser Leu Phe Ser Lys Glu Asn Leu Lys Asp 
    770                 775                 780                 


Val Cys Leu Lys Leu Asn Gly Glu Ala Glu Met Phe Phe Arg Lys Lys 
785                 790                 795                 800 


Ser Ile Asn Tyr Asp Glu Lys Lys Lys Arg Glu Gly His His Pro Glu 
                805                 810                 815     


Leu Phe Glu Lys Leu Lys Tyr Pro Ile Leu Lys Asp Lys Arg Tyr Ser 
            820                 825                 830         


Glu Asp Lys Phe Gln Phe His Leu Pro Ile Ser Leu Asn Phe Lys Ser 
        835                 840                 845             


Lys Glu Arg Leu Asn Phe Asn Leu Lys Val Asn Glu Phe Leu Lys Arg 
    850                 855                 860                 


Asn Lys Asp Ile Asn Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn Leu 
865                 870                 875                 880 


Leu Tyr Leu Val Met Ile Asn Gln Lys Gly Glu Ile Leu Lys Gln Thr 
                885                 890                 895     


Leu Leu Asp Ser Met Gln Ser Gly Lys Gly Arg Pro Glu Ile Asn Tyr 
            900                 905                 910         


Lys Glu Lys Leu Gln Glu Lys Glu Ile Glu Arg Asp Lys Ala Arg Lys 
        915                 920                 925             


Ser Trp Gly Thr Val Glu Asn Ile Lys Glu Leu Lys Glu Gly Tyr Leu 
    930                 935                 940                 


Ser Ile Val Ile His Gln Ile Ser Lys Leu Met Val Glu Asn Asn Ala 
945                 950                 955                 960 


Ile Val Val Leu Glu Asp Leu Asn Ile Gly Phe Lys Arg Gly Arg Gln 
                965                 970                 975     


Lys Val Glu Arg Gln Val Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp 
            980                 985                 990         


Lys Leu Asn Phe Leu Val Phe Lys  Glu Asn Lys Pro Thr  Glu Pro Gly 
        995                 1000                 1005             


Gly Val  Leu Lys Ala Tyr Gln  Leu Thr Asp Glu Phe  Gln Ser Phe 
    1010                 1015                 1020             


Glu Lys  Leu Ser Lys Gln Thr  Gly Phe Leu Phe Tyr  Val Pro Ser 
    1025                 1030                 1035             


Trp Asn  Thr Ser Lys Ile Asp  Pro Arg Thr Gly Phe  Ile Asp Phe 
    1040                 1045                 1050             


Leu His  Pro Ala Tyr Glu Asn  Ile Glu Lys Ala Lys  Gln Trp Ile 
    1055                 1060                 1065             


Asn Lys  Phe Asp Ser Ile Arg  Phe Asn Ser Lys Met  Asp Trp Phe 
    1070                 1075                 1080             


Glu Phe  Thr Ala Asp Thr Arg  Lys Phe Ser Glu Asn  Leu Met Leu 
    1085                 1090                 1095             


Gly Lys  Asn Arg Val Trp Val  Ile Cys Thr Thr Asn  Val Glu Arg 
    1100                 1105                 1110             


Tyr Phe  Thr Ser Lys Thr Ala  Asn Ser Ser Ile Gln  Tyr Asn Ser 
    1115                 1120                 1125             


Ile Gln  Ile Thr Glu Lys Leu  Lys Glu Leu Phe Val  Asp Ile Pro 
    1130                 1135                 1140             


Phe Ser  Asn Gly Gln Asp Leu  Lys Pro Glu Ile Leu  Arg Lys Asn 
    1145                 1150                 1155             


Asp Ala  Val Phe Phe Lys Ser  Leu Leu Phe Tyr Ile  Lys Thr Thr 
    1160                 1165                 1170             


Leu Ser  Leu Arg Gln Asn Asn  Gly Lys Lys Gly Glu  Glu Glu Lys 
    1175                 1180                 1185             


Asp Phe  Ile Leu Ser Pro Val  Val Asp Ser Lys Gly  Arg Phe Phe 
    1190                 1195                 1200             


Asn Ser  Leu Glu Ala Ser Asp  Asp Glu Pro Lys Asp  Ala Asp Ala 
    1205                 1210                 1215             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Leu Met  Asn Leu Leu 
    1220                 1225                 1230             


Val Leu  Asn Glu Thr Lys Glu  Glu Asn Leu Ser Arg  Pro Lys Trp 
    1235                 1240                 1245             


Lys Ile  Lys Asn Lys Asp Trp  Leu Glu Phe Val Trp  Glu Arg Asn 
    1250                 1255                 1260             


Arg 
    


<210>  11
<211>  1373
<212>  PRT
<213>  Moraxella bovoculi

<400>  11

Met Leu Phe Gln Asp Phe Thr His Leu Tyr Pro Leu Ser Lys Thr Val 
1               5                   10                  15      


Arg Phe Glu Leu Phe Ile Asp Arg Thr Leu Glu His Ile His Ala Lys 
            20                  25                  30          


Asn Phe Leu Ser Gln Asp Glu Thr Met Ala Asp Met His Gln Lys Val 
        35                  40                  45              


Lys Val Ile Leu Asp Asp Tyr His Arg Asp Phe Ile Ala Asp Met Met 
    50                  55                  60                  


Gly Glu Val Lys Leu Thr Lys Leu Ala Glu Phe Tyr Asp Val Tyr Leu 
65                  70                  75                  80  


Lys Phe Arg Lys Asn Pro Lys Asp Asp Glu Leu Gln Lys Ala Gln Leu 
                85                  90                  95      


Lys Asp Leu Gln Ala Val Leu Arg Lys Glu Ile Val Lys Pro Ile Gly 
            100                 105                 110         


Asn Gly Gly Lys Tyr Lys Ala Gly Tyr Asp Arg Leu Phe Gly Ala Lys 
        115                 120                 125             


Leu Phe Lys Asp Gly Lys Glu Leu Gly Asp Leu Ala Lys Phe Val Ile 
    130                 135                 140                 


Ala Gln Glu Gly Glu Ser Ser Pro Lys Leu Ala His Leu Ala His Phe 
145                 150                 155                 160 


Glu Lys Phe Ser Thr Tyr Phe Thr Gly Phe His Asp Asn Arg Lys Asn 
                165                 170                 175     


Met Tyr Ser Asp Glu Asp Lys His Thr Ala Ile Ala Tyr Arg Leu Ile 
            180                 185                 190         


His Glu Asn Leu Pro Arg Phe Ile Asp Asn Leu Gln Ile Leu Thr Thr 
        195                 200                 205             


Ile Lys Gln Lys His Ser Ala Leu Tyr Asp Gln Ile Ile Asn Glu Leu 
    210                 215                 220                 


Thr Ala Ser Gly Leu Asp Val Ser Leu Ala Ser His Leu Asp Gly Tyr 
225                 230                 235                 240 


His Lys Leu Leu Thr Gln Glu Gly Ile Thr Ala Tyr Asn Thr Leu Leu 
                245                 250                 255     


Gly Gly Ile Ser Gly Glu Ala Gly Ser Pro Lys Ile Gln Gly Ile Asn 
            260                 265                 270         


Glu Leu Ile Asn Ser His His Asn Gln His Cys His Lys Ser Glu Arg 
        275                 280                 285             


Ile Ala Lys Leu Arg Pro Leu His Lys Gln Ile Leu Ser Asp Gly Met 
    290                 295                 300                 


Ser Val Ser Phe Leu Pro Ser Lys Phe Ala Asp Asp Ser Glu Met Cys 
305                 310                 315                 320 


Gln Ala Val Asn Glu Phe Tyr Arg His Tyr Ala Asp Val Phe Ala Lys 
                325                 330                 335     


Val Gln Ser Leu Phe Asp Gly Phe Asp Asp His Gln Lys Asp Gly Ile 
            340                 345                 350         


Tyr Val Glu His Lys Asn Leu Asn Glu Leu Ser Lys Gln Ala Phe Gly 
        355                 360                 365             


Asp Phe Ala Leu Leu Gly Arg Val Leu Asp Gly Tyr Tyr Val Asp Val 
    370                 375                 380                 


Val Asn Pro Glu Phe Asn Glu Arg Phe Ala Lys Ala Lys Thr Asp Asn 
385                 390                 395                 400 


Ala Lys Ala Lys Leu Thr Lys Glu Lys Asp Lys Phe Ile Lys Gly Val 
                405                 410                 415     


His Ser Leu Ala Ser Leu Glu Gln Ala Ile Glu His Tyr Thr Ala Arg 
            420                 425                 430         


His Asp Asp Glu Ser Val Gln Ala Gly Lys Leu Gly Gln Tyr Phe Lys 
        435                 440                 445             


His Gly Leu Ala Gly Val Asp Asn Pro Ile Gln Lys Ile His Asn Asn 
    450                 455                 460                 


His Ser Thr Ile Lys Gly Phe Leu Glu Arg Glu Arg Pro Ala Gly Glu 
465                 470                 475                 480 


Arg Ala Leu Pro Lys Ile Lys Ser Gly Lys Asn Pro Glu Met Thr Gln 
                485                 490                 495     


Leu Arg Gln Leu Lys Glu Leu Leu Asp Asn Ala Leu Asn Val Ala His 
            500                 505                 510         


Phe Ala Lys Leu Leu Thr Thr Lys Thr Thr Leu Asp Asn Gln Asp Gly 
        515                 520                 525             


Asn Phe Tyr Gly Glu Phe Gly Val Leu Tyr Asp Glu Leu Ala Lys Ile 
    530                 535                 540                 


Pro Thr Leu Tyr Asn Lys Val Arg Asp Tyr Leu Ser Gln Lys Pro Phe 
545                 550                 555                 560 


Ser Thr Glu Lys Tyr Lys Leu Asn Phe Gly Asn Pro Thr Leu Leu Asn 
                565                 570                 575     


Gly Trp Asp Leu Asn Lys Glu Lys Asp Asn Phe Gly Val Ile Leu Gln 
            580                 585                 590         


Lys Asp Gly Cys Tyr Tyr Leu Ala Leu Leu Asp Lys Ala His Lys Lys 
        595                 600                 605             


Val Phe Asp Asn Ala Pro Asn Thr Gly Lys Ser Ile Tyr Gln Lys Met 
    610                 615                 620                 


Ile Tyr Lys Tyr Leu Glu Val Arg Lys Gln Phe Pro Lys Val Phe Phe 
625                 630                 635                 640 


Ser Lys Glu Ala Ile Ala Ile Asn Tyr His Pro Ser Lys Glu Leu Val 
                645                 650                 655     


Glu Ile Lys Asp Lys Gly Arg Gln Arg Ser Asp Asp Glu Arg Leu Lys 
            660                 665                 670         


Leu Tyr Arg Phe Ile Leu Glu Cys Leu Lys Ile His Pro Lys Tyr Asp 
        675                 680                 685             


Lys Lys Phe Glu Gly Ala Ile Gly Asp Ile Gln Leu Phe Lys Lys Asp 
    690                 695                 700                 


Lys Lys Gly Arg Glu Val Pro Ile Ser Glu Lys Asp Leu Phe Lys Asp 
705                 710                 715                 720 


Ile Asn Gly Ile Phe Ser Ser Lys Pro Lys Leu Glu Met Glu Asp Phe 
                725                 730                 735     


Phe Ile Gly Glu Phe Lys Arg Tyr Asn Pro Ser Gln Asp Leu Val Asp 
            740                 745                 750         


Gln Tyr Asn Ile Tyr Lys Lys Ile Asp Ser Asn Asp Asn Arg Lys Lys 
        755                 760                 765             


Glu Asn Phe Tyr Asn Asn His Pro Lys Phe Lys Lys Asp Leu Val Arg 
    770                 775                 780                 


Tyr Tyr Tyr Glu Ser Met Cys Lys His Glu Glu Trp Glu Glu Ser Phe 
785                 790                 795                 800 


Glu Phe Ser Lys Lys Leu Gln Asp Ile Gly Cys Tyr Val Asp Val Asn 
                805                 810                 815     


Glu Leu Phe Thr Glu Ile Glu Thr Arg Arg Leu Asn Tyr Lys Ile Ser 
            820                 825                 830         


Phe Cys Asn Ile Asn Ala Asp Tyr Ile Asp Glu Leu Val Glu Gln Gly 
        835                 840                 845             


Gln Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Pro Lys Ala 
    850                 855                 860                 


His Gly Lys Pro Asn Leu His Thr Leu Tyr Phe Lys Ala Leu Phe Ser 
865                 870                 875                 880 


Glu Asp Asn Leu Ala Asp Pro Ile Tyr Lys Leu Asn Gly Glu Ala Gln 
                885                 890                 895     


Ile Phe Tyr Arg Lys Ala Ser Leu Asp Met Asn Glu Thr Thr Ile His 
            900                 905                 910         


Arg Ala Gly Glu Val Leu Glu Asn Lys Asn Pro Asp Asn Pro Lys Lys 
        915                 920                 925             


Arg Gln Phe Val Tyr Asp Ile Ile Lys Asp Lys Arg Tyr Thr Gln Lys 
    930                 935                 940                 


Asp Phe Met Leu His Val Pro Ile Thr Met Asn Phe Gly Val Gln Gly 
945                 950                 955                 960 


Met Thr Ile Lys Glu Phe Asn Lys Lys Val Asn Gln Ser Ile Gln Gln 
                965                 970                 975     


Tyr Asp Glu Val Asn Val Ile Gly Ile Asp Arg Gly Glu Arg His Leu 
            980                 985                 990         


Leu Tyr Leu Thr Val Ile Asn Ser  Lys Gly Glu Ile Leu  Glu Gln Cys 
        995                 1000                 1005             


Ser Leu  Asn Asp Ile Thr Thr  Ala Ser Ala Asn Gly  Thr Gln Met 
    1010                 1015                 1020             


Thr Thr  Pro Tyr His Lys Ile  Leu Asp Lys Arg Glu  Ile Glu Arg 
    1025                 1030                 1035             


Leu Asn  Ala Arg Val Gly Trp  Gly Glu Ile Glu Thr  Ile Lys Glu 
    1040                 1045                 1050             


Leu Lys  Ser Gly Tyr Leu Ser  His Val Val His Gln  Ile Ser Gln 
    1055                 1060                 1065             


Leu Met  Leu Lys Tyr Asn Ala  Ile Val Val Leu Glu  Asp Leu Asn 
    1070                 1075                 1080             


Phe Gly  Phe Lys Arg Gly Arg  Phe Lys Val Glu Lys  Gln Ile Tyr 
    1085                 1090                 1095             


Gln Asn  Phe Glu Asn Ala Leu  Ile Lys Lys Leu Asn  His Leu Val 
    1100                 1105                 1110             


Leu Lys  Asp Lys Ala Asp Asp  Glu Ile Gly Ser Tyr  Lys Asn Ala 
    1115                 1120                 1125             


Leu Gln  Leu Thr Asn Asn Phe  Thr Asp Leu Lys Ser  Ile Gly Lys 
    1130                 1135                 1140             


Gln Thr  Gly Phe Leu Phe Tyr  Val Pro Ala Trp Asn  Thr Ser Lys 
    1145                 1150                 1155             


Ile Asp  Pro Glu Thr Gly Phe  Val Asp Leu Leu Lys  Pro Arg Tyr 
    1160                 1165                 1170             


Glu Asn  Ile Gln Ala Ser Gln  Ala Phe Phe Gly Lys  Phe Asp Lys 
    1175                 1180                 1185             


Ile Cys  Tyr Asn Ala Asp Lys  Asp Tyr Phe Glu Phe  His Ile Asp 
    1190                 1195                 1200             


Tyr Ala  Lys Phe Thr Asp Lys  Ala Lys Asn Ser Arg  Gln Ile Trp 
    1205                 1210                 1215             


Thr Ile  Cys Ser His Gly Asp  Lys Arg Tyr Val Tyr  Asp Lys Thr 
    1220                 1225                 1230             


Ala Asn  Gln Asn Lys Gly Ala  Ala Lys Gly Ile Asn  Val Asn Asp 
    1235                 1240                 1245             


Ile Leu  Lys Ser Leu Phe Ala  Arg His His Ile Asn  Glu Lys Gln 
    1250                 1255                 1260             


Pro Asn  Leu Val Met Asp Ile  Cys Gln Asn Asn Asp  Lys Glu Phe 
    1265                 1270                 1275             


His Lys  Ser Leu Met Tyr Leu  Leu Lys Thr Leu Leu  Ala Leu Arg 
    1280                 1285                 1290             


Tyr Ser  Asn Ala Ser Ser Asp  Glu Asp Phe Ile Leu  Ser Pro Val 
    1295                 1300                 1305             


Ala Asn  Asp Glu Gly Val Phe  Phe Asn Ser Ala Leu  Ala Asp Asp 
    1310                 1315                 1320             


Thr Gln  Pro Gln Asn Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala 
    1325                 1330                 1335             


Leu Lys  Gly Leu Trp Leu Leu  Asn Glu Leu Lys Asn  Ser Asp Asp 
    1340                 1345                 1350             


Leu Asn  Lys Val Lys Leu Ala  Ile Asp Asn Gln Thr  Trp Leu Asn 
    1355                 1360                 1365             


Phe Ala  Gln Asn Arg 
    1370             


<210>  12
<211>  1352
<212>  PRT
<213>  Unknown

<220>
<223>  Parcubacteria bacterium

<400>  12

Met Glu Asn Ile Phe Asp Gln Phe Ile Gly Lys Tyr Ser Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Glu Asp Phe Leu 
            20                  25                  30          


Lys Ile Asn Lys Val Phe Glu Lys Asp Gln Thr Ile Asp Asp Ser Tyr 
        35                  40                  45              


Asn Gln Ala Lys Phe Tyr Phe Asp Ser Leu His Gln Lys Phe Ile Asp 
    50                  55                  60                  


Ala Ala Leu Ala Ser Asp Lys Thr Ser Glu Leu Ser Phe Gln Asn Phe 
65                  70                  75                  80  


Ala Asp Val Leu Glu Lys Gln Asn Lys Ile Ile Leu Asp Lys Lys Arg 
                85                  90                  95      


Glu Met Gly Ala Leu Arg Lys Arg Asp Lys Asn Ala Val Gly Ile Asp 
            100                 105                 110         


Arg Leu Gln Lys Glu Ile Asn Asp Ala Glu Asp Ile Ile Gln Lys Glu 
        115                 120                 125             


Lys Glu Lys Ile Tyr Lys Asp Val Arg Thr Leu Phe Asp Asn Glu Ala 
    130                 135                 140                 


Glu Ser Trp Lys Thr Tyr Tyr Gln Glu Arg Glu Val Asp Gly Lys Lys 
145                 150                 155                 160 


Ile Thr Glu Ser Lys Ala Asp Leu Lys Gln Lys Gly Ala Asp Phe Leu 
                165                 170                 175     


Thr Ala Ala Gly Ile Leu Lys Val Leu Lys Tyr Glu Phe Pro Glu Glu 
            180                 185                 190         


Lys Glu Lys Glu Phe Gln Ala Lys Asn Gln Pro Ser Leu Phe Val Glu 
        195                 200                 205             


Glu Lys Glu Asn Pro Gly Gln Lys Arg Tyr Ile Phe Asp Ser Phe Asp 
    210                 215                 220                 


Lys Phe Ala Gly Tyr Leu Thr Lys Phe Gln Gln Thr Lys Lys Asn Leu 
225                 230                 235                 240 


Tyr Ala Ala Asp Gly Thr Ser Thr Ala Val Ala Thr Arg Ile Ala Asp 
                245                 250                 255     


Asn Phe Ile Ile Phe His Gln Asn Thr Lys Val Phe Arg Asp Lys Tyr 
            260                 265                 270         


Lys Asn Asn His Thr Asp Leu Gly Phe Asp Glu Glu Asn Ile Phe Glu 
        275                 280                 285             


Ile Glu Arg Tyr Lys Asn Cys Leu Leu Gln Arg Glu Ile Glu His Ile 
    290                 295                 300                 


Lys Asn Glu Asn Ser Tyr Asn Lys Ile Ile Gly Arg Ile Asn Lys Lys 
305                 310                 315                 320 


Ile Lys Glu Tyr Arg Asp Gln Lys Ala Lys Asp Thr Lys Leu Thr Lys 
                325                 330                 335     


Ser Asp Phe Pro Phe Phe Lys Asn Leu Asp Lys Gln Ile Leu Gly Glu 
            340                 345                 350         


Val Glu Lys Glu Lys Gln Leu Ile Glu Lys Thr Arg Glu Lys Thr Glu 
        355                 360                 365             


Glu Asp Val Leu Ile Glu Arg Phe Lys Glu Phe Ile Glu Asn Asn Glu 
    370                 375                 380                 


Glu Arg Phe Thr Ala Ala Lys Lys Leu Met Asn Ala Phe Cys Asn Gly 
385                 390                 395                 400 


Glu Phe Glu Ser Glu Tyr Glu Gly Ile Tyr Leu Lys Asn Lys Ala Ile 
                405                 410                 415     


Asn Thr Ile Ser Arg Arg Trp Phe Val Ser Asp Arg Asp Phe Glu Leu 
            420                 425                 430         


Lys Leu Pro Gln Gln Lys Ser Lys Asn Lys Ser Glu Lys Asn Glu Pro 
        435                 440                 445             


Lys Val Lys Lys Phe Ile Ser Ile Ala Glu Ile Lys Asn Ala Val Glu 
    450                 455                 460                 


Glu Leu Asp Gly Asp Ile Phe Lys Ala Val Phe Tyr Asp Lys Lys Ile 
465                 470                 475                 480 


Ile Ala Gln Gly Gly Ser Lys Leu Glu Gln Phe Leu Val Ile Trp Lys 
                485                 490                 495     


Tyr Glu Phe Glu Tyr Leu Phe Arg Asp Ile Glu Arg Glu Asn Gly Glu 
            500                 505                 510         


Lys Leu Leu Gly Tyr Asp Ser Cys Leu Lys Ile Ala Lys Gln Leu Gly 
        515                 520                 525             


Ile Phe Pro Gln Glu Lys Glu Ala Arg Glu Lys Ala Thr Ala Val Ile 
    530                 535                 540                 


Lys Asn Tyr Ala Asp Ala Gly Leu Gly Ile Phe Gln Met Met Lys Tyr 
545                 550                 555                 560 


Phe Ser Leu Asp Asp Lys Asp Arg Lys Asn Thr Pro Gly Gln Leu Ser 
                565                 570                 575     


Thr Asn Phe Tyr Ala Glu Tyr Asp Gly Tyr Tyr Lys Asp Phe Glu Phe 
            580                 585                 590         


Ile Lys Tyr Tyr Asn Glu Phe Arg Asn Phe Ile Thr Lys Lys Pro Phe 
        595                 600                 605             


Asp Glu Asp Lys Ile Lys Leu Asn Phe Glu Asn Gly Ala Leu Leu Lys 
    610                 615                 620                 


Gly Trp Asp Glu Asn Lys Glu Tyr Asp Phe Met Gly Val Ile Leu Lys 
625                 630                 635                 640 


Lys Glu Gly Arg Leu Tyr Leu Gly Ile Met His Lys Asn His Arg Lys 
                645                 650                 655     


Leu Phe Gln Ser Met Gly Asn Ala Lys Gly Asp Asn Ala Asn Arg Tyr 
            660                 665                 670         


Gln Lys Met Ile Tyr Lys Gln Ile Ala Asp Ala Ser Lys Asp Val Pro 
        675                 680                 685             


Arg Leu Leu Leu Thr Ser Lys Lys Ala Met Glu Lys Phe Lys Pro Ser 
    690                 695                 700                 


Gln Glu Ile Leu Arg Ile Lys Lys Glu Lys Thr Phe Lys Arg Glu Ser 
705                 710                 715                 720 


Lys Asn Phe Ser Leu Arg Asp Leu His Ala Leu Ile Glu Tyr Tyr Arg 
                725                 730                 735     


Asn Cys Ile Pro Gln Tyr Ser Asn Trp Ser Phe Tyr Asp Phe Gln Phe 
            740                 745                 750         


Gln Asp Thr Gly Lys Tyr Gln Asn Ile Lys Glu Phe Thr Asp Asp Val 
        755                 760                 765             


Gln Lys Tyr Gly Tyr Lys Ile Ser Phe Arg Asp Ile Asp Asp Glu Tyr 
    770                 775                 780                 


Ile Asn Gln Ala Leu Asn Glu Gly Lys Met Tyr Leu Phe Glu Val Val 
785                 790                 795                 800 


Asn Lys Asp Ile Tyr Asn Thr Lys Asn Gly Ser Lys Asn Leu His Thr 
                805                 810                 815     


Leu Tyr Phe Glu His Ile Leu Ser Ala Glu Asn Leu Asn Asp Pro Val 
            820                 825                 830         


Phe Lys Leu Ser Gly Met Ala Glu Ile Phe Gln Arg Gln Pro Ser Val 
        835                 840                 845             


Asn Glu Arg Glu Lys Ile Thr Thr Gln Lys Asn Gln Cys Ile Leu Asp 
    850                 855                 860                 


Lys Gly Asp Arg Ala Tyr Lys Tyr Arg Arg Tyr Thr Glu Lys Lys Ile 
865                 870                 875                 880 


Met Phe His Met Ser Leu Val Leu Asn Thr Gly Lys Gly Glu Ile Lys 
                885                 890                 895     


Gln Val Gln Phe Asn Lys Ile Ile Asn Gln Arg Ile Ser Ser Ser Asp 
            900                 905                 910         


Asn Glu Met Arg Val Asn Val Ile Gly Ile Asp Arg Gly Glu Lys Asn 
        915                 920                 925             


Leu Leu Tyr Tyr Ser Val Val Lys Gln Asn Gly Glu Ile Ile Glu Gln 
    930                 935                 940                 


Ala Ser Leu Asn Glu Ile Asn Gly Val Asn Tyr Arg Asp Lys Leu Ile 
945                 950                 955                 960 


Glu Arg Glu Lys Glu Arg Leu Lys Asn Arg Gln Ser Trp Lys Pro Val 
                965                 970                 975     


Val Lys Ile Lys Asp Leu Lys Lys Gly Tyr Ile Ser His Val Ile His 
            980                 985                 990         


Lys Ile Cys Gln Leu Ile Glu Lys  Tyr Ser Ala Ile Val  Val Leu Glu 
        995                 1000                 1005             


Asp Leu  Asn Met Arg Phe Lys  Gln Ile Arg Gly Gly  Ile Glu Arg 
    1010                 1015                 1020             


Ser Val  Tyr Gln Gln Phe Glu  Lys Ala Leu Ile Asp  Lys Leu Gly 
    1025                 1030                 1035             


Tyr Leu  Val Phe Lys Asp Asn  Arg Asp Leu Arg Ala  Pro Gly Gly 
    1040                 1045                 1050             


Val Leu  Asn Gly Tyr Gln Leu  Ser Ala Pro Phe Val  Ser Phe Glu 
    1055                 1060                 1065             


Lys Met  Arg Lys Gln Thr Gly  Ile Leu Phe Tyr Thr  Gln Ala Glu 
    1070                 1075                 1080             


Tyr Thr  Ser Lys Thr Asp Pro  Ile Thr Gly Phe Arg  Lys Asn Val 
    1085                 1090                 1095             


Tyr Ile  Ser Asn Ser Ala Ser  Leu Asp Lys Ile Lys  Glu Ala Val 
    1100                 1105                 1110             


Lys Lys  Phe Asp Ala Ile Gly  Trp Asp Gly Lys Glu  Gln Ser Tyr 
    1115                 1120                 1125             


Phe Phe  Lys Tyr Asn Pro Tyr  Asn Leu Ala Asp Glu  Lys Tyr Lys 
    1130                 1135                 1140             


Asn Ser  Thr Val Ser Lys Glu  Trp Ala Ile Phe Ala  Ser Ala Pro 
    1145                 1150                 1155             


Arg Ile  Arg Arg Gln Lys Gly  Glu Asp Gly Tyr Trp  Lys Tyr Asp 
    1160                 1165                 1170             


Arg Val  Lys Val Asn Glu Glu  Phe Glu Lys Leu Leu  Lys Val Trp 
    1175                 1180                 1185             


Asn Phe  Val Asn Pro Lys Ala  Thr Asp Ile Lys Gln  Glu Ile Ile 
    1190                 1195                 1200             


Lys Lys  Ile Lys Ala Gly Asp  Leu Gln Gly Glu Lys  Glu Leu Asp 
    1205                 1210                 1215             


Gly Arg  Leu Arg Asn Phe Trp  His Ser Phe Ile Tyr  Leu Phe Asn 
    1220                 1225                 1230             


Leu Val  Leu Glu Leu Arg Asn  Ser Phe Ser Leu Gln  Ile Lys Ile 
    1235                 1240                 1245             


Lys Ala  Gly Glu Val Ile Ala  Val Asp Glu Gly Val  Asp Phe Ile 
    1250                 1255                 1260             


Ala Ser  Pro Val Lys Pro Phe  Phe Thr Thr Pro Asn  Pro Tyr Ile 
    1265                 1270                 1275             


Pro Ser  Asn Leu Cys Trp Leu  Ala Val Glu Asn Ala  Asp Ala Asn 
    1280                 1285                 1290             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Gly Val Met Ile  Leu Lys Lys 
    1295                 1300                 1305             


Ile Arg  Glu His Ala Lys Lys  Asp Pro Glu Phe Lys  Lys Leu Pro 
    1310                 1315                 1320             


Asn Leu  Phe Ile Ser Asn Ala  Glu Trp Asp Glu Ala  Ala Arg Asp 
    1325                 1330                 1335             


Trp Gly  Lys Tyr Ala Gly Thr  Thr Ala Leu Asn Leu  Asp His 
    1340                 1345                 1350         


<210>  13
<211>  1260
<212>  PRT
<213>  Porphyromonas crevioricanis

<400>  13

Met Asp Ser Leu Lys Asp Phe Thr Asn Leu Tyr Pro Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Val Gly Lys Thr Leu Glu Asn Ile Glu 
            20                  25                  30          


Lys Ala Gly Ile Leu Lys Glu Asp Glu His Arg Ala Glu Ser Tyr Arg 
        35                  40                  45              


Arg Val Lys Lys Ile Ile Asp Thr Tyr His Lys Val Phe Ile Asp Ser 
    50                  55                  60                  


Ser Leu Glu Asn Met Ala Lys Met Gly Ile Glu Asn Glu Ile Lys Ala 
65                  70                  75                  80  


Met Leu Gln Ser Phe Cys Glu Leu Tyr Lys Lys Asp His Arg Thr Glu 
                85                  90                  95      


Gly Glu Asp Lys Ala Leu Asp Lys Ile Arg Ala Val Leu Arg Gly Leu 
            100                 105                 110         


Ile Val Gly Ala Phe Thr Gly Val Cys Gly Arg Arg Glu Asn Thr Val 
        115                 120                 125             


Gln Asn Glu Lys Tyr Glu Ser Leu Phe Lys Glu Lys Leu Ile Lys Glu 
    130                 135                 140                 


Ile Leu Pro Asp Phe Val Leu Ser Thr Glu Ala Glu Ser Leu Pro Phe 
145                 150                 155                 160 


Ser Val Glu Glu Ala Thr Arg Ser Leu Lys Glu Phe Asp Ser Phe Thr 
                165                 170                 175     


Ser Tyr Phe Ala Gly Phe Tyr Glu Asn Arg Lys Asn Ile Tyr Ser Thr 
            180                 185                 190         


Lys Pro Gln Ser Thr Ala Ile Ala Tyr Arg Leu Ile His Glu Asn Leu 
        195                 200                 205             


Pro Lys Phe Ile Asp Asn Ile Leu Val Phe Gln Lys Ile Lys Glu Pro 
    210                 215                 220                 


Ile Ala Lys Glu Leu Glu His Ile Arg Ala Asp Phe Ser Ala Gly Gly 
225                 230                 235                 240 


Tyr Ile Lys Lys Asp Glu Arg Leu Glu Asp Ile Phe Ser Leu Asn Tyr 
                245                 250                 255     


Tyr Ile His Val Leu Ser Gln Ala Gly Ile Glu Lys Tyr Asn Ala Leu 
            260                 265                 270         


Ile Gly Lys Ile Val Thr Glu Gly Asp Gly Glu Met Lys Gly Leu Asn 
        275                 280                 285             


Glu His Ile Asn Leu Tyr Asn Gln Gln Arg Gly Arg Glu Asp Arg Leu 
    290                 295                 300                 


Pro Leu Phe Arg Pro Leu Tyr Lys Gln Ile Leu Ser Asp Arg Glu Gln 
305                 310                 315                 320 


Leu Ser Tyr Leu Pro Glu Ser Phe Glu Lys Asp Glu Glu Leu Leu Arg 
                325                 330                 335     


Ala Leu Lys Glu Phe Tyr Asp His Ile Ala Glu Asp Ile Leu Gly Arg 
            340                 345                 350         


Thr Gln Gln Leu Met Thr Ser Ile Ser Glu Tyr Asp Leu Ser Arg Ile 
        355                 360                 365             


Tyr Val Arg Asn Asp Ser Gln Leu Thr Asp Ile Ser Lys Lys Met Leu 
    370                 375                 380                 


Gly Asp Trp Asn Ala Ile Tyr Met Ala Arg Glu Arg Ala Tyr Asp His 
385                 390                 395                 400 


Glu Gln Ala Pro Lys Arg Ile Thr Ala Lys Tyr Glu Arg Asp Arg Ile 
                405                 410                 415     


Lys Ala Leu Lys Gly Glu Glu Ser Ile Ser Leu Ala Asn Leu Asn Ser 
            420                 425                 430         


Cys Ile Ala Phe Leu Asp Asn Val Arg Asp Cys Arg Val Asp Thr Tyr 
        435                 440                 445             


Leu Ser Thr Leu Gly Gln Lys Glu Gly Pro His Gly Leu Ser Asn Leu 
    450                 455                 460                 


Val Glu Asn Val Phe Ala Ser Tyr His Glu Ala Glu Gln Leu Leu Ser 
465                 470                 475                 480 


Phe Pro Tyr Pro Glu Glu Asn Asn Leu Ile Gln Asp Lys Asp Asn Val 
                485                 490                 495     


Val Leu Ile Lys Asn Leu Leu Asp Asn Ile Ser Asp Leu Gln Arg Phe 
            500                 505                 510         


Leu Lys Pro Leu Trp Gly Met Gly Asp Glu Pro Asp Lys Asp Glu Arg 
        515                 520                 525             


Phe Tyr Gly Glu Tyr Asn Tyr Ile Arg Gly Ala Leu Asp Gln Val Ile 
    530                 535                 540                 


Pro Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Arg Lys Pro Tyr Ser 
545                 550                 555                 560 


Thr Arg Lys Val Lys Leu Asn Phe Gly Asn Ser Gln Leu Leu Ser Gly 
                565                 570                 575     


Trp Asp Arg Asn Lys Glu Lys Asp Asn Ser Cys Val Ile Leu Arg Lys 
            580                 585                 590         


Gly Gln Asn Phe Tyr Leu Ala Ile Met Asn Asn Arg His Lys Arg Ser 
        595                 600                 605             


Phe Glu Asn Lys Met Leu Pro Glu Tyr Lys Glu Gly Glu Pro Tyr Phe 
    610                 615                 620                 


Glu Lys Met Asp Tyr Lys Phe Leu Pro Asp Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Leu Ser Lys Lys Gly Ile Glu Ile Tyr Lys Pro Ser Pro 
                645                 650                 655     


Lys Leu Leu Glu Gln Tyr Gly His Gly Thr His Lys Lys Gly Asp Thr 
            660                 665                 670         


Phe Ser Met Asp Asp Leu His Glu Leu Ile Asp Phe Phe Lys His Ser 
        675                 680                 685             


Ile Glu Ala His Glu Asp Trp Lys Gln Phe Gly Phe Lys Phe Ser Asp 
    690                 695                 700                 


Thr Ala Thr Tyr Glu Asn Val Ser Ser Phe Tyr Arg Glu Val Glu Asp 
705                 710                 715                 720 


Gln Gly Tyr Lys Leu Ser Phe Arg Lys Val Ser Glu Ser Tyr Val Tyr 
                725                 730                 735     


Ser Leu Ile Asp Gln Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
            740                 745                 750         


Asp Phe Ser Pro Cys Ser Lys Gly Thr Pro Asn Leu His Thr Leu Tyr 
        755                 760                 765             


Trp Arg Met Leu Phe Asp Glu Arg Asn Leu Ala Asp Val Ile Tyr Lys 
    770                 775                 780                 


Leu Asp Gly Lys Ala Glu Ile Phe Phe Arg Glu Lys Ser Leu Lys Asn 
785                 790                 795                 800 


Asp His Pro Thr His Pro Ala Gly Lys Pro Ile Lys Lys Lys Ser Arg 
                805                 810                 815     


Gln Lys Lys Gly Glu Glu Ser Leu Phe Glu Tyr Asp Leu Val Lys Asp 
            820                 825                 830         


Arg Arg Tyr Thr Met Asp Lys Phe Gln Phe His Val Pro Ile Thr Met 
        835                 840                 845             


Asn Phe Lys Cys Ser Ala Gly Ser Lys Val Asn Asp Met Val Asn Ala 
    850                 855                 860                 


His Ile Arg Glu Ala Lys Asp Met His Val Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg Asn Leu Leu Tyr Ile Cys Val Ile Asp Ser Arg Gly Thr Ile 
                885                 890                 895     


Leu Asp Gln Ile Ser Leu Asn Thr Ile Asn Asp Ile Asp Tyr His Asp 
            900                 905                 910         


Leu Leu Glu Ser Arg Asp Lys Asp Arg Gln Gln Glu His Arg Asn Trp 
        915                 920                 925             


Gln Thr Ile Glu Gly Ile Lys Glu Leu Lys Gln Gly Tyr Leu Ser Gln 
    930                 935                 940                 


Ala Val His Arg Ile Ala Glu Leu Met Val Ala Tyr Lys Ala Val Val 
945                 950                 955                 960 


Ala Leu Glu Asp Leu Asn Met Gly Phe Lys Arg Gly Arg Gln Lys Val 
                965                 970                 975     


Glu Ser Ser Val Tyr Gln Gln Phe Glu Lys Gln Leu Ile Asp Lys Leu 
            980                 985                 990         


Asn Tyr Leu Val Asp Lys Lys Lys  Arg Pro Glu Asp Ile  Gly Gly Leu 
        995                 1000                 1005             


Leu Arg  Ala Tyr Gln Phe Thr  Ala Pro Phe Lys Ser  Phe Lys Glu 
    1010                 1015                 1020             


Met Gly  Lys Gln Asn Gly Phe  Leu Phe Tyr Ile Pro  Ala Trp Asn 
    1025                 1030                 1035             


Thr Ser  Asn Ile Asp Pro Thr  Thr Gly Phe Val Asn  Leu Phe His 
    1040                 1045                 1050             


Val Gln  Tyr Glu Asn Val Asp  Lys Ala Lys Ser Phe  Phe Gln Lys 
    1055                 1060                 1065             


Phe Asp  Ser Ile Ser Tyr Asn  Pro Lys Lys Asp Trp  Phe Glu Phe 
    1070                 1075                 1080             


Ala Phe  Asp Tyr Lys Asn Phe  Thr Lys Lys Ala Glu  Gly Ser Arg 
    1085                 1090                 1095             


Ser Met  Trp Ile Leu Cys Thr  His Gly Ser Arg Ile  Lys Asn Phe 
    1100                 1105                 1110             


Arg Asn  Ser Gln Lys Asn Gly  Gln Trp Asp Ser Glu  Glu Phe Ala 
    1115                 1120                 1125             


Leu Thr  Glu Ala Phe Lys Ser  Leu Phe Val Arg Tyr  Glu Ile Asp 
    1130                 1135                 1140             


Tyr Thr  Ala Asp Leu Lys Thr  Ala Ile Val Asp Glu  Lys Gln Lys 
    1145                 1150                 1155             


Asp Phe  Phe Val Asp Leu Leu  Lys Leu Phe Lys Leu  Thr Val Gln 
    1160                 1165                 1170             


Met Arg  Asn Ser Trp Lys Glu  Lys Asp Leu Asp Tyr  Leu Ile Ser 
    1175                 1180                 1185             


Pro Val  Ala Gly Ala Asp Gly  Arg Phe Phe Asp Thr  Arg Glu Gly 
    1190                 1195                 1200             


Asn Lys  Ser Leu Pro Lys Asp  Ala Asp Ala Asn Gly  Ala Tyr Asn 
    1205                 1210                 1215             


Ile Ala  Leu Lys Gly Leu Trp  Ala Leu Arg Gln Ile  Arg Gln Thr 
    1220                 1225                 1230             


Ser Glu  Gly Gly Lys Leu Lys  Leu Ala Ile Ser Asn  Lys Glu Trp 
    1235                 1240                 1245             


Leu Gln  Phe Val Gln Glu Arg  Ser Tyr Glu Lys Asp  
    1250                 1255                 1260 


<210>  14
<211>  1324
<212>  PRT
<213>  Prevotella disiens

<400>  14

Met Glu Asn Tyr Gln Glu Phe Thr Asn Leu Phe Gln Leu Asn Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Cys Glu Leu Leu Glu 
            20                  25                  30          


Glu Gly Lys Ile Phe Ala Ser Gly Ser Phe Leu Glu Lys Asp Lys Val 
        35                  40                  45              


Arg Ala Asp Asn Val Ser Tyr Val Lys Lys Glu Ile Asp Lys Lys His 
    50                  55                  60                  


Lys Ile Phe Ile Glu Glu Thr Leu Ser Ser Phe Ser Ile Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Lys Gln Tyr Phe Asp Cys Tyr Asn Glu Leu Lys Ala Phe Lys 
                85                  90                  95      


Lys Asp Cys Lys Ser Asp Glu Glu Glu Val Lys Lys Thr Ala Leu Arg 
            100                 105                 110         


Asn Lys Cys Thr Ser Ile Gln Arg Ala Met Arg Glu Ala Ile Ser Gln 
        115                 120                 125             


Ala Phe Leu Lys Ser Pro Gln Lys Lys Leu Leu Ala Ile Lys Asn Leu 
    130                 135                 140                 


Ile Glu Asn Val Phe Lys Ala Asp Glu Asn Val Gln His Phe Ser Glu 
145                 150                 155                 160 


Phe Thr Ser Tyr Phe Ser Gly Phe Glu Thr Asn Arg Glu Asn Phe Tyr 
                165                 170                 175     


Ser Asp Glu Glu Lys Ser Thr Ser Ile Ala Tyr Arg Leu Val His Asp 
            180                 185                 190         


Asn Leu Pro Ile Phe Ile Lys Asn Ile Tyr Ile Phe Glu Lys Leu Lys 
        195                 200                 205             


Glu Gln Phe Asp Ala Lys Thr Leu Ser Glu Ile Phe Glu Asn Tyr Lys 
    210                 215                 220                 


Leu Tyr Val Ala Gly Ser Ser Leu Asp Glu Val Phe Ser Leu Glu Tyr 
225                 230                 235                 240 


Phe Asn Asn Thr Leu Thr Gln Lys Gly Ile Asp Asn Tyr Asn Ala Val 
                245                 250                 255     


Ile Gly Lys Ile Val Lys Glu Asp Lys Gln Glu Ile Gln Gly Leu Asn 
            260                 265                 270         


Glu His Ile Asn Leu Tyr Asn Gln Lys His Lys Asp Arg Arg Leu Pro 
        275                 280                 285             


Phe Phe Ile Ser Leu Lys Lys Gln Ile Leu Ser Asp Arg Glu Ala Leu 
    290                 295                 300                 


Ser Trp Leu Pro Asp Met Phe Lys Asn Asp Ser Glu Val Ile Asp Ala 
305                 310                 315                 320 


Leu Lys Gly Phe Tyr Ile Glu Asp Gly Phe Glu Asn Asn Val Leu Thr 
                325                 330                 335     


Pro Leu Ala Thr Leu Leu Ser Ser Leu Asp Lys Tyr Asn Leu Asn Gly 
            340                 345                 350         


Ile Phe Ile Arg Asn Asn Glu Ala Leu Ser Ser Leu Ser Gln Asn Val 
        355                 360                 365             


Tyr Arg Asn Phe Ser Ile Asp Glu Ala Ile Asp Ala Gln Asn Ala Glu 
    370                 375                 380                 


Leu Gln Thr Phe Asn Asn Tyr Glu Leu Ile Ala Asn Ala Leu Arg Ala 
385                 390                 395                 400 


Lys Ile Lys Lys Glu Thr Lys Gln Gly Arg Lys Ser Phe Glu Lys Tyr 
                405                 410                 415     


Glu Glu Tyr Ile Asp Lys Lys Val Lys Ala Ile Asp Ser Leu Ser Ile 
            420                 425                 430         


Gln Glu Ile Asn Glu Leu Val Glu Asn Tyr Val Ser Glu Phe Asn Ser 
        435                 440                 445             


Asn Ser Gly Asn Met Pro Arg Lys Val Glu Asp Tyr Phe Ser Leu Met 
    450                 455                 460                 


Arg Lys Gly Asp Phe Gly Ser Asn Asp Leu Ile Glu Asn Ile Lys Thr 
465                 470                 475                 480 


Lys Leu Ser Ala Ala Glu Lys Leu Leu Gly Thr Lys Tyr Gln Glu Thr 
                485                 490                 495     


Ala Lys Asp Ile Phe Lys Lys Asp Glu Asn Ser Lys Leu Ile Lys Glu 
            500                 505                 510         


Leu Leu Asp Ala Thr Lys Gln Phe Gln His Phe Ile Lys Pro Leu Leu 
        515                 520                 525             


Gly Thr Gly Glu Glu Ala Asp Arg Asp Leu Val Phe Tyr Gly Asp Phe 
    530                 535                 540                 


Leu Pro Leu Tyr Glu Lys Phe Glu Glu Leu Thr Leu Leu Tyr Asn Lys 
545                 550                 555                 560 


Val Arg Asn Arg Leu Thr Gln Lys Pro Tyr Ser Lys Asp Lys Ile Arg 
                565                 570                 575     


Leu Cys Phe Asn Lys Pro Lys Leu Met Thr Gly Trp Val Asp Ser Lys 
            580                 585                 590         


Thr Glu Lys Ser Asp Asn Gly Thr Gln Tyr Gly Gly Tyr Leu Phe Arg 
        595                 600                 605             


Lys Lys Asn Glu Ile Gly Glu Tyr Asp Tyr Phe Leu Gly Ile Ser Ser 
    610                 615                 620                 


Lys Ala Gln Leu Phe Arg Lys Asn Glu Ala Val Ile Gly Asp Tyr Glu 
625                 630                 635                 640 


Arg Leu Asp Tyr Tyr Gln Pro Lys Ala Asn Thr Ile Tyr Gly Ser Ala 
                645                 650                 655     


Tyr Glu Gly Glu Asn Ser Tyr Lys Glu Asp Lys Lys Arg Leu Asn Lys 
            660                 665                 670         


Val Ile Ile Ala Tyr Ile Glu Gln Ile Lys Gln Thr Asn Ile Lys Lys 
        675                 680                 685             


Ser Ile Ile Glu Ser Ile Ser Lys Tyr Pro Asn Ile Ser Asp Asp Asp 
    690                 695                 700                 


Lys Val Thr Pro Ser Ser Leu Leu Glu Lys Ile Lys Lys Val Ser Ile 
705                 710                 715                 720 


Asp Ser Tyr Asn Gly Ile Leu Ser Phe Lys Ser Phe Gln Ser Val Asn 
                725                 730                 735     


Lys Glu Val Ile Asp Asn Leu Leu Lys Thr Ile Ser Pro Leu Lys Asn 
            740                 745                 750         


Lys Ala Glu Phe Leu Asp Leu Ile Asn Lys Asp Tyr Gln Ile Phe Thr 
        755                 760                 765             


Glu Val Gln Ala Val Ile Asp Glu Ile Cys Lys Gln Lys Thr Phe Ile 
    770                 775                 780                 


Tyr Phe Pro Ile Ser Asn Val Glu Leu Glu Lys Glu Met Gly Asp Lys 
785                 790                 795                 800 


Asp Lys Pro Leu Cys Leu Phe Gln Ile Ser Asn Lys Asp Leu Ser Phe 
                805                 810                 815     


Ala Lys Thr Phe Ser Ala Asn Leu Arg Lys Lys Arg Gly Ala Glu Asn 
            820                 825                 830         


Leu His Thr Met Leu Phe Lys Ala Leu Met Glu Gly Asn Gln Asp Asn 
        835                 840                 845             


Leu Asp Leu Gly Ser Gly Ala Ile Phe Tyr Arg Ala Lys Ser Leu Asp 
    850                 855                 860                 


Gly Asn Lys Pro Thr His Pro Ala Asn Glu Ala Ile Lys Cys Arg Asn 
865                 870                 875                 880 


Val Ala Asn Lys Asp Lys Val Ser Leu Phe Thr Tyr Asp Ile Tyr Lys 
                885                 890                 895     


Asn Arg Arg Tyr Met Glu Asn Lys Phe Leu Phe His Leu Ser Ile Val 
            900                 905                 910         


Gln Asn Tyr Lys Ala Ala Asn Asp Ser Ala Gln Leu Asn Ser Ser Ala 
        915                 920                 925             


Thr Glu Tyr Ile Arg Lys Ala Asp Asp Leu His Ile Ile Gly Ile Asp 
    930                 935                 940                 


Arg Gly Glu Arg Asn Leu Leu Tyr Tyr Ser Val Ile Asp Met Lys Gly 
945                 950                 955                 960 


Asn Ile Val Glu Gln Asp Ser Leu Asn Ile Ile Arg Asn Asn Asp Leu 
                965                 970                 975     


Glu Thr Asp Tyr His Asp Leu Leu Asp Lys Arg Glu Lys Glu Arg Lys 
            980                 985                 990         


Ala Asn Arg Gln Asn Trp Glu Ala  Val Glu Gly Ile Lys  Asp Leu Lys 
        995                 1000                 1005             


Lys Gly  Tyr Leu Ser Gln Ala  Val His Gln Ile Ala  Gln Leu Met 
    1010                 1015                 1020             


Leu Lys  Tyr Asn Ala Ile Ile  Ala Leu Glu Asp Leu  Gly Gln Met 
    1025                 1030                 1035             


Phe Val  Thr Arg Gly Gln Lys  Ile Glu Lys Ala Val  Tyr Gln Gln 
    1040                 1045                 1050             


Phe Glu  Lys Ser Leu Val Asp  Lys Leu Ser Tyr Leu  Val Asp Lys 
    1055                 1060                 1065             


Lys Arg  Pro Tyr Asn Glu Leu  Gly Gly Ile Leu Lys  Ala Tyr Gln 
    1070                 1075                 1080             


Leu Ala  Ser Ser Ile Thr Lys  Asn Asn Ser Asp Lys  Gln Asn Gly 
    1085                 1090                 1095             


Phe Leu  Phe Tyr Val Pro Ala  Trp Asn Thr Ser Lys  Ile Asp Pro 
    1100                 1105                 1110             


Val Thr  Gly Phe Thr Asp Leu  Leu Arg Pro Lys Ala  Met Thr Ile 
    1115                 1120                 1125             


Lys Glu  Ala Gln Asp Phe Phe  Gly Ala Phe Asp Asn  Ile Ser Tyr 
    1130                 1135                 1140             


Asn Asp  Lys Gly Tyr Phe Glu  Phe Glu Thr Asn Tyr  Asp Lys Phe 
    1145                 1150                 1155             


Lys Ile  Arg Met Lys Ser Ala  Gln Thr Arg Trp Thr  Ile Cys Thr 
    1160                 1165                 1170             


Phe Gly  Asn Arg Ile Lys Arg  Lys Lys Asp Lys Asn  Tyr Trp Asn 
    1175                 1180                 1185             


Tyr Glu  Glu Val Glu Leu Thr  Glu Glu Phe Lys Lys  Leu Phe Lys 
    1190                 1195                 1200             


Asp Ser  Asn Ile Asp Tyr Glu  Asn Cys Asn Leu Lys  Glu Glu Ile 
    1205                 1210                 1215             


Gln Asn  Lys Asp Asn Arg Lys  Phe Phe Asp Asp Leu  Ile Lys Leu 
    1220                 1225                 1230             


Leu Gln  Leu Thr Leu Gln Met  Arg Asn Ser Asp Asp  Lys Gly Asn 
    1235                 1240                 1245             


Asp Tyr  Ile Ile Ser Pro Val  Ala Asn Ala Glu Gly  Gln Phe Phe 
    1250                 1255                 1260             


Asp Ser  Arg Asn Gly Asp Lys  Lys Leu Pro Leu Asp  Ala Asp Ala 
    1265                 1270                 1275             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Gly Leu Trp  Asn Ile Arg 
    1280                 1285                 1290             


Gln Ile  Lys Gln Thr Lys Asn  Lys Asp Asp Leu Asn  Leu Ser Ile 
    1295                 1300                 1305             


Ser Ser  Thr Glu Trp Leu Asp  Phe Val Arg Glu Lys  Pro Tyr Leu 
    1310                 1315                 1320             


Lys 
    


<210>  15
<211>  1484
<212>  PRT
<213>  Unknown

<220>
<223>  Peregrinibacteria bacterium


<220>
<221>  misc_feature
<222>  (1073)..(1073)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Ser Asn Phe Phe Lys Asn Phe Thr Asn Leu Tyr Glu Leu Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Lys Pro Val Gly Asp Thr Leu Thr Asn Met 
            20                  25                  30          


Lys Asp His Leu Glu Tyr Asp Glu Lys Leu Gln Thr Phe Leu Lys Asp 
        35                  40                  45              


Gln Asn Ile Asp Asp Ala Tyr Gln Ala Leu Lys Pro Gln Phe Asp Glu 
    50                  55                  60                  


Ile His Glu Glu Phe Ile Thr Asp Ser Leu Glu Ser Lys Lys Ala Lys 
65                  70                  75                  80  


Glu Ile Asp Phe Ser Glu Tyr Leu Asp Leu Phe Gln Glu Lys Lys Glu 
                85                  90                  95      


Leu Asn Asp Ser Glu Lys Lys Leu Arg Asn Lys Ile Gly Glu Thr Phe 
            100                 105                 110         


Asn Lys Ala Gly Glu Lys Trp Lys Lys Glu Lys Tyr Pro Gln Tyr Glu 
        115                 120                 125             


Trp Lys Lys Gly Ser Lys Ile Ala Asn Gly Ala Asp Ile Leu Ser Cys 
    130                 135                 140                 


Gln Asp Met Leu Gln Phe Ile Lys Tyr Lys Asn Pro Glu Asp Glu Lys 
145                 150                 155                 160 


Ile Lys Asn Tyr Ile Asp Asp Thr Leu Lys Gly Phe Phe Thr Tyr Phe 
                165                 170                 175     


Gly Gly Phe Asn Gln Asn Arg Ala Asn Tyr Tyr Glu Thr Lys Lys Glu 
            180                 185                 190         


Ala Ser Thr Ala Val Ala Thr Arg Ile Val His Glu Asn Leu Pro Lys 
        195                 200                 205             


Phe Cys Asp Asn Val Ile Gln Phe Lys His Ile Ile Lys Arg Lys Lys 
    210                 215                 220                 


Asp Gly Thr Val Glu Lys Thr Glu Arg Lys Thr Glu Tyr Leu Asn Ala 
225                 230                 235                 240 


Tyr Gln Tyr Leu Lys Asn Asn Asn Lys Ile Thr Gln Ile Lys Asp Ala 
                245                 250                 255     


Glu Thr Glu Lys Met Ile Glu Ser Thr Pro Ile Ala Glu Lys Ile Phe 
            260                 265                 270         


Asp Val Tyr Tyr Phe Ser Ser Cys Leu Ser Gln Lys Gln Ile Glu Glu 
        275                 280                 285             


Tyr Asn Arg Ile Ile Gly His Tyr Asn Leu Leu Ile Asn Leu Tyr Asn 
    290                 295                 300                 


Gln Ala Lys Arg Ser Glu Gly Lys His Leu Ser Ala Asn Glu Lys Lys 
305                 310                 315                 320 


Tyr Lys Asp Leu Pro Lys Phe Lys Thr Leu Tyr Lys Gln Ile Gly Cys 
                325                 330                 335     


Gly Lys Lys Lys Asp Leu Phe Tyr Thr Ile Lys Cys Asp Thr Glu Glu 
            340                 345                 350         


Glu Ala Asn Lys Ser Arg Asn Glu Gly Lys Glu Ser His Ser Val Glu 
        355                 360                 365             


Glu Ile Ile Asn Lys Ala Gln Glu Ala Ile Asn Lys Tyr Phe Lys Ser 
    370                 375                 380                 


Asn Asn Asp Cys Glu Asn Ile Asn Thr Val Pro Asp Phe Ile Asn Tyr 
385                 390                 395                 400 


Ile Leu Thr Lys Glu Asn Tyr Glu Gly Val Tyr Trp Ser Lys Ala Ala 
                405                 410                 415     


Met Asn Thr Ile Ser Asp Lys Tyr Phe Ala Asn Tyr His Asp Leu Gln 
            420                 425                 430         


Asp Arg Leu Lys Glu Ala Lys Val Phe Gln Lys Ala Asp Lys Lys Ser 
        435                 440                 445             


Glu Asp Asp Ile Lys Ile Pro Glu Ala Ile Glu Leu Ser Gly Leu Phe 
    450                 455                 460                 


Gly Val Leu Asp Ser Leu Ala Asp Trp Gln Thr Thr Leu Phe Lys Ser 
465                 470                 475                 480 


Ser Ile Leu Ser Asn Glu Lys Leu Lys Ile Ile Thr Asp Ser Gln Thr 
                485                 490                 495     


Pro Ser Glu Ala Leu Leu Lys Met Ile Phe Asn Asp Ile Glu Lys Asn 
            500                 505                 510         


Met Glu Ser Phe Leu Lys Glu Thr Asn Asp Ile Ile Thr Leu Lys Lys 
        515                 520                 525             


Tyr Lys Gly Asn Lys Glu Gly Thr Glu Lys Ile Lys Gln Trp Phe Asp 
    530                 535                 540                 


Tyr Thr Leu Ala Ile Asn Arg Met Leu Lys Tyr Phe Leu Val Lys Glu 
545                 550                 555                 560 


Asn Lys Ile Lys Gly Asn Ser Leu Asp Thr Asn Ile Ser Glu Ala Leu 
                565                 570                 575     


Lys Thr Leu Ile Tyr Ser Asp Asp Ala Glu Trp Phe Lys Trp Tyr Asp 
            580                 585                 590         


Ala Leu Arg Asn Tyr Leu Thr Gln Lys Pro Gln Asp Glu Ala Lys Glu 
        595                 600                 605             


Asn Lys Leu Lys Leu Asn Phe Asp Asn Pro Ser Leu Ala Gly Gly Trp 
    610                 615                 620                 


Asp Val Asn Lys Glu Cys Ser Asn Phe Cys Val Ile Leu Lys Asp Lys 
625                 630                 635                 640 


Asn Glu Lys Lys Tyr Leu Ala Met Ile Lys Lys Gly Glu Asn Thr Leu 
                645                 650                 655     


Phe Gln Lys Glu Trp Thr Glu Gly Arg Gly Lys Asn Leu Thr Lys Lys 
            660                 665                 670         


Ser Asn Pro Leu Phe Glu Ile Asn Asn Cys Glu Ile Leu Ser Lys Met 
        675                 680                 685             


Glu Tyr Asp Phe Trp Ala Asp Val Ser Lys Met Ile Pro Lys Cys Ser 
    690                 695                 700                 


Thr Gln Leu Lys Ala Val Val Asn His Phe Lys Gln Ser Asp Asn Glu 
705                 710                 715                 720 


Phe Ile Phe Pro Ile Gly Tyr Lys Val Thr Ser Gly Glu Lys Phe Arg 
                725                 730                 735     


Glu Glu Cys Lys Ile Ser Lys Gln Asp Phe Glu Leu Asn Asn Lys Val 
            740                 745                 750         


Phe Asn Lys Asn Glu Leu Ser Val Thr Ala Met Arg Tyr Asp Leu Ser 
        755                 760                 765             


Ser Thr Gln Glu Lys Gln Tyr Ile Lys Ala Phe Gln Lys Glu Tyr Trp 
    770                 775                 780                 


Glu Leu Leu Phe Lys Gln Glu Lys Arg Asp Thr Lys Leu Thr Asn Asn 
785                 790                 795                 800 


Glu Ile Phe Asn Glu Trp Ile Asn Phe Cys Asn Lys Lys Tyr Ser Glu 
                805                 810                 815     


Leu Leu Ser Trp Glu Arg Lys Tyr Lys Asp Ala Leu Thr Asn Trp Ile 
            820                 825                 830         


Asn Phe Cys Lys Tyr Phe Leu Ser Lys Tyr Pro Lys Thr Thr Leu Phe 
        835                 840                 845             


Asn Tyr Ser Phe Lys Glu Ser Glu Asn Tyr Asn Ser Leu Asp Glu Phe 
    850                 855                 860                 


Tyr Arg Asp Val Asp Ile Cys Ser Tyr Lys Leu Asn Ile Asn Thr Thr 
865                 870                 875                 880 


Ile Asn Lys Ser Ile Leu Asp Arg Leu Val Glu Glu Gly Lys Leu Tyr 
                885                 890                 895     


Leu Phe Glu Ile Lys Asn Gln Asp Ser Asn Asp Gly Lys Ser Ile Gly 
            900                 905                 910         


His Lys Asn Asn Leu His Thr Ile Tyr Trp Asn Ala Ile Phe Glu Asn 
        915                 920                 925             


Phe Asp Asn Arg Pro Lys Leu Asn Gly Glu Ala Glu Ile Phe Tyr Arg 
    930                 935                 940                 


Lys Ala Ile Ser Lys Asp Lys Leu Gly Ile Val Lys Gly Lys Lys Thr 
945                 950                 955                 960 


Lys Asn Gly Thr Trp Ile Ile Lys Asn Tyr Arg Phe Ser Lys Glu Lys 
                965                 970                 975     


Phe Ile Leu His Val Pro Ile Thr Leu Asn Phe Cys Ser Asn Asn Glu 
            980                 985                 990         


Tyr Val Asn Asp Ile Val Asn Thr  Lys Phe Tyr Asn Phe  Ser Asn Leu 
        995                 1000                 1005             


His Phe  Leu Gly Ile Asp Arg  Gly Glu Lys His Leu  Ala Tyr Tyr 
    1010                 1015                 1020             


Ser Leu  Val Asn Lys Asn Gly  Glu Ile Val Asp Gln  Gly Thr Leu 
    1025                 1030                 1035             


Asn Leu  Pro Phe Thr Asp Lys  Asp Gly Asn Gln Arg  Ser Ile Lys 
    1040                 1045                 1050             


Lys Glu  Lys Tyr Phe Tyr Asn  Lys Gln Glu Asp Lys  Trp Glu Ala 
    1055                 1060                 1065             


Lys Glu  Val Asp Xaa Trp Asn  Tyr Asn Asp Leu Leu  Asp Ala Met 
    1070                 1075                 1080             


Ala Ser  Asn Arg Asp Met Ala  Arg Lys Asn Trp Gln  Arg Ile Gly 
    1085                 1090                 1095             


Thr Ile  Lys Glu Ala Lys Asn  Gly Tyr Val Ser Leu  Val Ile Arg 
    1100                 1105                 1110             


Lys Ile  Ala Asp Leu Ala Val  Asn Asn Glu Arg Pro  Ala Phe Ile 
    1115                 1120                 1125             


Val Leu  Glu Asp Leu Asn Thr  Gly Phe Lys Arg Ser  Arg Gln Lys 
    1130                 1135                 1140             


Ile Asp  Lys Ser Val Tyr Gln  Lys Phe Glu Leu Ala  Leu Ala Lys 
    1145                 1150                 1155             


Lys Leu  Asn Phe Leu Val Asp  Lys Asn Ala Lys Arg  Asp Glu Ile 
    1160                 1165                 1170             


Gly Ser  Pro Thr Lys Ala Leu  Gln Leu Thr Pro Pro  Val Asn Asn 
    1175                 1180                 1185             


Tyr Gly  Asp Ile Glu Asn Lys  Lys Gln Ala Gly Ile  Met Leu Tyr 
    1190                 1195                 1200             


Thr Arg  Ala Asn Tyr Thr Ser  Gln Thr Asp Pro Ala  Thr Gly Trp 
    1205                 1210                 1215             


Arg Lys  Thr Ile Tyr Leu Lys  Ala Gly Pro Glu Glu  Thr Thr Tyr 
    1220                 1225                 1230             


Lys Lys  Asp Gly Lys Ile Lys  Asn Lys Ser Val Lys  Asp Gln Ile 
    1235                 1240                 1245             


Ile Glu  Thr Phe Thr Asp Ile  Gly Phe Asp Gly Lys  Asp Tyr Tyr 
    1250                 1255                 1260             


Phe Glu  Tyr Asp Lys Gly Glu  Phe Val Asp Glu Lys  Thr Gly Glu 
    1265                 1270                 1275             


Ile Lys  Pro Lys Lys Trp Arg  Leu Tyr Ser Gly Glu  Asn Gly Lys 
    1280                 1285                 1290             


Ser Leu  Asp Arg Phe Arg Gly  Glu Arg Glu Lys Asp  Lys Tyr Glu 
    1295                 1300                 1305             


Trp Lys  Ile Asp Lys Ile Asp  Ile Val Lys Ile Leu  Asp Asp Leu 
    1310                 1315                 1320             


Phe Val  Asn Phe Asp Lys Asn  Ile Ser Leu Leu Lys  Gln Leu Lys 
    1325                 1330                 1335             


Glu Gly  Val Glu Leu Thr Arg  Asn Asn Glu His Gly  Thr Gly Glu 
    1340                 1345                 1350             


Ser Leu  Arg Phe Ala Ile Asn  Leu Ile Gln Gln Ile  Arg Asn Thr 
    1355                 1360                 1365             


Gly Asn  Asn Glu Arg Asp Asn  Asp Phe Ile Leu Ser  Pro Val Arg 
    1370                 1375                 1380             


Asp Glu  Asn Gly Lys His Phe  Asp Ser Arg Glu Tyr  Trp Asp Lys 
    1385                 1390                 1395             


Glu Thr  Lys Gly Glu Lys Ile  Ser Met Pro Ser Ser  Gly Asp Ala 
    1400                 1405                 1410             


Asn Gly  Ala Phe Asn Ile Ala  Arg Lys Gly Ile Ile  Met Asn Ala 
    1415                 1420                 1425             


His Ile  Leu Ala Asn Ser Asp  Ser Lys Asp Leu Ser  Leu Phe Val 
    1430                 1435                 1440             


Ser Asp  Glu Glu Trp Asp Leu  His Leu Asn Asn Lys  Thr Glu Trp 
    1445                 1450                 1455             


Lys Lys  Gln Leu Asn Ile Phe  Ser Ser Arg Lys Ala  Met Ala Lys 
    1460                 1465                 1470             


Arg Lys  Lys Lys Arg Pro Ala  Ala Thr Lys Lys 
    1475                 1480                 


<210>  16
<211>  1245
<212>  PRT
<213>  Porphyromonas macacae

<400>  16

Met Lys Thr Gln His Phe Phe Glu Asp Phe Thr Ser Leu Tyr Ser Leu 
1               5                   10                  15      


Ser Lys Thr Ile Arg Phe Glu Leu Lys Pro Ile Gly Lys Thr Leu Glu 
            20                  25                  30          


Asn Ile Lys Lys Asn Gly Leu Ile Arg Arg Asp Glu Gln Arg Leu Asp 
        35                  40                  45              


Asp Tyr Glu Lys Leu Lys Lys Val Ile Asp Glu Tyr His Glu Asp Phe 
    50                  55                  60                  


Ile Ala Asn Ile Leu Ser Ser Phe Ser Phe Ser Glu Glu Ile Leu Gln 
65                  70                  75                  80  


Ser Tyr Ile Gln Asn Leu Ser Ile Ser Glu Ala Arg Ala Lys Ile Glu 
                85                  90                  95      


Lys Thr Met Arg Asp Thr Leu Ala Lys Ala Phe Ser Glu Asp Glu Arg 
            100                 105                 110         


Tyr Lys Ser Ile Phe Lys Lys Glu Leu Val Lys Lys Asp Ile Pro Val 
        115                 120                 125             


Trp Cys Pro Ala Tyr Lys Ser Leu Cys Lys Lys Phe Asp Asn Phe Thr 
    130                 135                 140                 


Thr Ser Leu Val Pro Phe His Glu Asn Arg Lys Asn Leu Tyr Thr Ser 
145                 150                 155                 160 


Asn Glu Ile Thr Ala Ser Ile Pro Tyr Arg Ile Val His Val Asn Leu 
                165                 170                 175     


Pro Lys Phe Ile Gln Asn Ile Glu Ala Leu Cys Glu Leu Gln Lys Lys 
            180                 185                 190         


Met Gly Ala Asp Leu Tyr Leu Glu Met Met Glu Asn Leu Arg Asn Val 
        195                 200                 205             


Trp Pro Ser Phe Val Lys Thr Pro Asp Asp Leu Cys Asn Leu Lys Thr 
    210                 215                 220                 


Tyr Asn His Leu Met Val Gln Ser Ser Ile Ser Glu Tyr Asn Arg Phe 
225                 230                 235                 240 


Val Gly Gly Tyr Ser Thr Glu Asp Gly Thr Lys His Gln Gly Ile Asn 
                245                 250                 255     


Glu Trp Ile Asn Ile Tyr Arg Gln Arg Asn Lys Glu Met Arg Leu Pro 
            260                 265                 270         


Gly Leu Val Phe Leu His Lys Gln Ile Leu Ala Lys Val Asp Ser Ser 
        275                 280                 285             


Ser Phe Ile Ser Asp Thr Leu Glu Asn Asp Asp Gln Val Phe Cys Val 
    290                 295                 300                 


Leu Arg Gln Phe Arg Lys Leu Phe Trp Asn Thr Val Ser Ser Lys Glu 
305                 310                 315                 320 


Asp Asp Ala Ala Ser Leu Lys Asp Leu Phe Cys Gly Leu Ser Gly Tyr 
                325                 330                 335     


Asp Pro Glu Ala Ile Tyr Val Ser Asp Ala His Leu Ala Thr Ile Ser 
            340                 345                 350         


Lys Asn Ile Phe Asp Arg Trp Asn Tyr Ile Ser Asp Ala Ile Arg Arg 
        355                 360                 365             


Lys Thr Glu Val Leu Met Pro Arg Lys Lys Glu Ser Val Glu Arg Tyr 
    370                 375                 380                 


Ala Glu Lys Ile Ser Lys Gln Ile Lys Lys Arg Gln Ser Tyr Ser Leu 
385                 390                 395                 400 


Ala Glu Leu Asp Asp Leu Leu Ala His Tyr Ser Glu Glu Ser Leu Pro 
                405                 410                 415     


Ala Gly Phe Ser Leu Leu Ser Tyr Phe Thr Ser Leu Gly Gly Gln Lys 
            420                 425                 430         


Tyr Leu Val Ser Asp Gly Glu Val Ile Leu Tyr Glu Glu Gly Ser Asn 
        435                 440                 445             


Ile Trp Asp Glu Val Leu Ile Ala Phe Arg Asp Leu Gln Val Ile Leu 
    450                 455                 460                 


Asp Lys Asp Phe Thr Glu Lys Lys Leu Gly Lys Asp Glu Glu Ala Val 
465                 470                 475                 480 


Ser Val Ile Lys Lys Ala Leu Asp Ser Ala Leu Arg Leu Arg Lys Phe 
                485                 490                 495     


Phe Asp Leu Leu Ser Gly Thr Gly Ala Glu Ile Arg Arg Asp Ser Ser 
            500                 505                 510         


Phe Tyr Ala Leu Tyr Thr Asp Arg Met Asp Lys Leu Lys Gly Leu Leu 
        515                 520                 525             


Lys Met Tyr Asp Lys Val Arg Asn Tyr Leu Thr Lys Lys Pro Tyr Ser 
    530                 535                 540                 


Ile Glu Lys Phe Lys Leu His Phe Asp Asn Pro Ser Leu Leu Ser Gly 
545                 550                 555                 560 


Trp Asp Lys Asn Lys Glu Leu Asn Asn Leu Ser Val Ile Phe Arg Gln 
                565                 570                 575     


Asn Gly Tyr Tyr Tyr Leu Gly Ile Met Thr Pro Lys Gly Lys Asn Leu 
            580                 585                 590         


Phe Lys Thr Leu Pro Lys Leu Gly Ala Glu Glu Met Phe Tyr Glu Lys 
        595                 600                 605             


Met Glu Tyr Lys Gln Ile Ala Glu Pro Met Leu Met Leu Pro Lys Val 
    610                 615                 620                 


Phe Phe Pro Lys Lys Thr Lys Pro Ala Phe Ala Pro Asp Gln Ser Val 
625                 630                 635                 640 


Val Asp Ile Tyr Asn Lys Lys Thr Phe Lys Thr Gly Gln Lys Gly Phe 
                645                 650                 655     


Asn Lys Lys Asp Leu Tyr Arg Leu Ile Asp Phe Tyr Lys Glu Ala Leu 
            660                 665                 670         


Thr Val His Glu Trp Lys Leu Phe Asn Phe Ser Phe Ser Pro Thr Glu 
        675                 680                 685             


Gln Tyr Arg Asn Ile Gly Glu Phe Phe Asp Glu Val Arg Glu Gln Ala 
    690                 695                 700                 


Tyr Lys Val Ser Met Val Asn Val Pro Ala Ser Tyr Ile Asp Glu Ala 
705                 710                 715                 720 


Val Glu Asn Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe 
                725                 730                 735     


Ser Pro Tyr Ser Lys Gly Ile Pro Asn Leu His Thr Leu Tyr Trp Lys 
            740                 745                 750         


Ala Leu Phe Ser Glu Gln Asn Gln Ser Arg Val Tyr Lys Leu Cys Gly 
        755                 760                 765             


Gly Gly Glu Leu Phe Tyr Arg Lys Ala Ser Leu His Met Gln Asp Thr 
    770                 775                 780                 


Thr Val His Pro Lys Gly Ile Ser Ile His Lys Lys Asn Leu Asn Lys 
785                 790                 795                 800 


Lys Gly Glu Thr Ser Leu Phe Asn Tyr Asp Leu Val Lys Asp Lys Arg 
                805                 810                 815     


Phe Thr Glu Asp Lys Phe Phe Phe His Val Pro Ile Ser Ile Asn Tyr 
            820                 825                 830         


Lys Asn Lys Lys Ile Thr Asn Val Asn Gln Met Val Arg Asp Tyr Ile 
        835                 840                 845             


Ala Gln Asn Asp Asp Leu Gln His Gly Ile Asp Arg Gly Glu Arg Asn 
    850                 855                 860                 


Leu Leu Tyr Ile Ser Arg Ile Asp Thr Arg Gly Asn Leu Leu Glu Gln 
865                 870                 875                 880 


Phe Ser Leu Asn Val Ile Glu Ser Asp Lys Gly Asp Leu Arg Thr Asp 
                885                 890                 895     


Tyr Gln Lys Ile Leu Gly Asp Arg Glu Gln Glu Arg Leu Arg Arg Arg 
            900                 905                 910         


Gln Glu Trp Lys Ser Ile Glu Ser Ile Lys Asp Leu Lys Asp Gly Tyr 
        915                 920                 925             


Met Ser Gln Val Val His Lys Ile Cys Asn Met Val Val Glu His Lys 
    930                 935                 940                 


Ala Ile Val Val Leu Glu Asn Leu Asn Leu Ser Phe Met Lys Gly Arg 
945                 950                 955                 960 


Lys Lys Val Glu Lys Ser Val Tyr Glu Lys Phe Glu Arg Met Leu Val 
                965                 970                 975     


Asp Lys Leu Asn Tyr Leu Val Val Asp Lys Lys Asn Leu Ser Asn Glu 
            980                 985                 990         


Pro Gly Gly Leu Tyr Ala Ala Tyr  Gln Leu Thr Asn Pro  Leu Phe Ser 
        995                 1000                 1005             


Phe Glu  Glu Leu His Arg Tyr  Pro Gln Ser Gly Ile  Leu Phe Phe 
    1010                 1015                 1020             


Val Asp  Pro Trp Asn Thr Ser  Leu Thr Asp Pro Ser  Thr Gly Phe 
    1025                 1030                 1035             


Val Asn  Leu Leu Gly Arg Ile  Asn Tyr Thr Asn Val  Gly Asp Ala 
    1040                 1045                 1050             


Arg Lys  Phe Phe Asp Arg Phe  Asn Ala Ile Arg Tyr  Asp Gly Lys 
    1055                 1060                 1065             


Gly Asn  Ile Leu Phe Asp Leu  Asp Leu Ser Arg Phe  Asp Val Arg 
    1070                 1075                 1080             


Val Glu  Thr Gln Arg Lys Leu  Trp Thr Leu Thr Thr  Phe Gly Ser 
    1085                 1090                 1095             


Arg Ile  Ala Lys Ser Lys Lys  Ser Gly Lys Trp Met  Val Glu Arg 
    1100                 1105                 1110             


Ile Glu  Asn Leu Ser Leu Cys  Phe Leu Glu Leu Phe  Glu Gln Phe 
    1115                 1120                 1125             


Asn Ile  Gly Tyr Arg Val Glu  Lys Asp Leu Lys Lys  Ala Ile Leu 
    1130                 1135                 1140             


Ser Gln  Asp Arg Lys Glu Phe  Tyr Val Arg Leu Ile  Tyr Leu Phe 
    1145                 1150                 1155             


Asn Leu  Met Met Gln Ile Arg  Asn Ser Asp Gly Glu  Glu Asp Tyr 
    1160                 1165                 1170             


Ile Leu  Ser Pro Ala Leu Asn  Glu Lys Asn Leu Gln  Phe Asp Ser 
    1175                 1180                 1185             


Arg Leu  Ile Glu Ala Lys Asp  Leu Pro Val Asp Ala  Asp Ala Asn 
    1190                 1195                 1200             


Gly Ala  Tyr Asn Val Ala Arg  Lys Gly Leu Met Val  Val Gln Arg 
    1205                 1210                 1215             


Ile Lys  Arg Gly Asp His Glu  Ser Ile His Arg Ile  Gly Arg Ala 
    1220                 1225                 1230             


Gln Trp  Leu Arg Tyr Val Gln  Glu Gly Ile Val Glu  
    1235                 1240                 1245 


<210>  17
<211>  1250
<212>  PRT
<213>  Smithella sp.

<400>  17

Met Gln Thr Leu Phe Glu Asn Phe Thr Asn Gln Tyr Pro Val Ser Lys 
1               5                   10                  15      


Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Lys Asp Phe Ile 
            20                  25                  30          


Glu Gln Lys Gly Leu Leu Lys Lys Asp Glu Asp Arg Ala Glu Lys Tyr 
        35                  40                  45              


Lys Lys Val Lys Asn Ile Ile Asp Glu Tyr His Lys Asp Phe Ile Glu 
    50                  55                  60                  


Lys Ser Leu Asn Gly Leu Lys Leu Asp Gly Leu Glu Lys Tyr Lys Thr 
65                  70                  75                  80  


Leu Tyr Leu Lys Gln Glu Lys Asp Asp Lys Asp Lys Lys Ala Phe Asp 
                85                  90                  95      


Lys Glu Lys Glu Asn Leu Arg Lys Gln Ile Ala Asn Ala Phe Arg Asn 
            100                 105                 110         


Asn Glu Lys Phe Lys Thr Leu Phe Ala Lys Glu Leu Ile Lys Asn Asp 
        115                 120                 125             


Leu Met Ser Phe Ala Cys Glu Glu Asp Lys Lys Asn Val Lys Glu Phe 
    130                 135                 140                 


Glu Ala Phe Thr Thr Tyr Phe Thr Gly Phe His Gln Asn Arg Ala Asn 
145                 150                 155                 160 


Met Tyr Val Ala Asp Glu Lys Arg Thr Ala Ile Ala Ser Arg Leu Ile 
                165                 170                 175     


His Glu Asn Leu Pro Lys Phe Ile Asp Asn Ile Lys Ile Phe Glu Lys 
            180                 185                 190         


Met Lys Lys Glu Ala Pro Glu Leu Leu Ser Pro Phe Asn Gln Thr Leu 
        195                 200                 205             


Lys Asp Met Lys Asp Val Ile Lys Gly Thr Thr Leu Glu Glu Ile Phe 
    210                 215                 220                 


Ser Leu Asp Tyr Phe Asn Lys Thr Leu Thr Gln Ser Gly Ile Asp Ile 
225                 230                 235                 240 


Tyr Asn Ser Val Ile Gly Gly Arg Thr Pro Glu Glu Gly Lys Thr Lys 
                245                 250                 255     


Ile Lys Gly Leu Asn Glu Tyr Ile Asn Thr Asp Phe Asn Gln Lys Gln 
            260                 265                 270         


Thr Asp Lys Lys Lys Arg Gln Pro Lys Phe Lys Gln Leu Tyr Lys Gln 
        275                 280                 285             


Ile Leu Ser Asp Arg Gln Ser Leu Ser Phe Ile Ala Glu Ala Phe Lys 
    290                 295                 300                 


Asn Asp Thr Glu Ile Leu Glu Ala Ile Glu Lys Phe Tyr Val Asn Glu 
305                 310                 315                 320 


Leu Leu His Phe Ser Asn Glu Gly Lys Ser Thr Asn Val Leu Asp Ala 
                325                 330                 335     


Ile Lys Asn Ala Val Ser Asn Leu Glu Ser Phe Asn Leu Thr Lys Met 
            340                 345                 350         


Tyr Phe Arg Ser Gly Ala Ser Leu Thr Asp Val Ser Arg Lys Val Phe 
        355                 360                 365             


Gly Glu Trp Ser Ile Ile Asn Arg Ala Leu Asp Asn Tyr Tyr Ala Thr 
    370                 375                 380                 


Thr Tyr Pro Ile Lys Pro Arg Glu Lys Ser Glu Lys Tyr Glu Glu Arg 
385                 390                 395                 400 


Lys Glu Lys Trp Leu Lys Gln Asp Phe Asn Val Ser Leu Ile Gln Thr 
                405                 410                 415     


Ala Ile Asp Glu Tyr Asp Asn Glu Thr Val Lys Gly Lys Asn Ser Gly 
            420                 425                 430         


Lys Val Ile Ala Asp Tyr Phe Ala Lys Phe Cys Asp Asp Lys Glu Thr 
        435                 440                 445             


Asp Leu Ile Gln Lys Val Asn Glu Gly Tyr Ile Ala Val Lys Asp Leu 
    450                 455                 460                 


Leu Asn Thr Pro Cys Pro Glu Asn Glu Lys Leu Gly Ser Asn Lys Asp 
465                 470                 475                 480 


Gln Val Lys Gln Ile Lys Ala Phe Met Asp Ser Ile Met Asp Ile Met 
                485                 490                 495     


His Phe Val Arg Pro Leu Ser Leu Lys Asp Thr Asp Lys Glu Lys Asp 
            500                 505                 510         


Glu Thr Phe Tyr Ser Leu Phe Thr Pro Leu Tyr Asp His Leu Thr Gln 
        515                 520                 525             


Thr Ile Ala Leu Tyr Asn Lys Val Arg Asn Tyr Leu Thr Gln Lys Pro 
    530                 535                 540                 


Tyr Ser Thr Glu Lys Ile Lys Leu Asn Phe Glu Asn Ser Thr Leu Leu 
545                 550                 555                 560 


Gly Gly Trp Asp Leu Asn Lys Glu Thr Asp Asn Thr Ala Ile Ile Leu 
                565                 570                 575     


Arg Lys Asp Asn Leu Tyr Tyr Leu Gly Ile Met Asp Lys Arg His Asn 
            580                 585                 590         


Arg Ile Phe Arg Asn Val Pro Lys Ala Asp Lys Lys Asp Phe Cys Tyr 
        595                 600                 605             


Glu Lys Met Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro 
    610                 615                 620                 


Lys Val Phe Phe Ser Gln Ser Arg Ile Gln Glu Phe Thr Pro Ser Ala 
625                 630                 635                 640 


Lys Leu Leu Glu Asn Tyr Ala Asn Glu Thr His Lys Lys Gly Asp Asn 
                645                 650                 655     


Phe Asn Leu Asn His Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser 
            660                 665                 670         


Ile Asn Lys His Glu Asp Trp Lys Asn Phe Asp Phe Arg Phe Ser Ala 
        675                 680                 685             


Thr Ser Thr Tyr Ala Asp Leu Ser Gly Phe Tyr His Glu Val Glu His 
    690                 695                 700                 


Gln Gly Tyr Lys Ile Ser Phe Gln Ser Val Ala Asp Ser Phe Ile Asp 
705                 710                 715                 720 


Asp Leu Val Asn Glu Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys 
                725                 730                 735     


Asp Phe Ser Pro Phe Ser Lys Gly Lys Pro Asn Leu His Thr Leu Tyr 
            740                 745                 750         


Trp Lys Met Leu Phe Asp Glu Asn Asn Leu Lys Asp Val Val Tyr Lys 
        755                 760                 765             


Leu Asn Gly Glu Ala Glu Val Phe Tyr Arg Lys Lys Ser Ile Ala Glu 
    770                 775                 780                 


Lys Asn Thr Thr Ile His Lys Ala Asn Glu Ser Ile Ile Asn Lys Asn 
785                 790                 795                 800 


Pro Asp Asn Pro Lys Ala Thr Ser Thr Phe Asn Tyr Asp Ile Val Lys 
                805                 810                 815     


Asp Lys Arg Tyr Thr Ile Asp Lys Phe Gln Phe His Ile Pro Ile Thr 
            820                 825                 830         


Met Asn Phe Lys Ala Glu Gly Ile Phe Asn Met Asn Gln Arg Val Asn 
        835                 840                 845             


Gln Phe Leu Lys Ala Asn Pro Asp Ile Asn Ile Ile Gly Ile Asp Arg 
    850                 855                 860                 


Gly Glu Arg His Leu Leu Tyr Tyr Ala Leu Ile Asn Gln Lys Gly Lys 
865                 870                 875                 880 


Ile Leu Lys Gln Asp Thr Leu Asn Val Ile Ala Asn Glu Lys Gln Lys 
                885                 890                 895     


Val Asp Tyr His Asn Leu Leu Asp Lys Lys Glu Gly Asp Arg Ala Thr 
            900                 905                 910         


Ala Arg Gln Glu Trp Gly Val Ile Glu Thr Ile Lys Glu Leu Lys Glu 
        915                 920                 925             


Gly Tyr Leu Ser Gln Val Ile His Lys Leu Thr Asp Leu Met Ile Glu 
    930                 935                 940                 


Asn Asn Ala Ile Ile Val Met Glu Asp Leu Asn Phe Gly Phe Lys Arg 
945                 950                 955                 960 


Gly Arg Gln Lys Val Glu Lys Gln Val Tyr Gln Lys Phe Glu Lys Met 
                965                 970                 975     


Leu Ile Asp Lys Leu Asn Tyr Leu Val Asp Lys Asn Lys Lys Ala Asn 
            980                 985                 990         


Glu Leu Gly Gly Leu Leu Asn Ala  Phe Gln Leu Ala Asn  Lys Phe Glu 
        995                 1000                 1005             


Ser Phe  Gln Lys Met Gly Lys  Gln Asn Gly Phe Ile  Phe Tyr Val 
    1010                 1015                 1020             


Pro Ala  Trp Asn Thr Ser Lys  Thr Asp Pro Ala Thr  Gly Phe Ile 
    1025                 1030                 1035             


Asp Phe  Leu Lys Pro Arg Tyr  Glu Asn Leu Asn Gln  Ala Lys Asp 
    1040                 1045                 1050             


Phe Phe  Glu Lys Phe Asp Ser  Ile Arg Leu Asn Ser  Lys Ala Asp 
    1055                 1060                 1065             


Tyr Phe  Glu Phe Ala Phe Asp  Phe Lys Asn Phe Thr  Glu Lys Ala 
    1070                 1075                 1080             


Asp Gly  Gly Arg Thr Lys Trp  Thr Val Cys Thr Thr  Asn Glu Asp 
    1085                 1090                 1095             


Arg Tyr  Gln Trp Asn Arg Ala  Leu Asn Asn Asn Arg  Gly Ser Gln 
    1100                 1105                 1110             


Glu Lys  Tyr Asp Ile Thr Ala  Glu Leu Lys Ser Leu  Phe Asp Gly 
    1115                 1120                 1125             


Lys Val  Asp Tyr Lys Ser Gly  Lys Asp Leu Lys Gln  Gln Ile Ala 
    1130                 1135                 1140             


Ser Gln  Glu Ser Ala Asp Phe  Phe Lys Ala Leu Met  Lys Asn Leu 
    1145                 1150                 1155             


Ser Ile  Thr Leu Ser Leu Arg  His Asn Asn Gly Glu  Lys Gly Asp 
    1160                 1165                 1170             


Asn Glu  Gln Asp Tyr Ile Leu  Ser Pro Val Ala Asp  Ser Lys Gly 
    1175                 1180                 1185             


Arg Phe  Phe Asp Ser Arg Lys  Ala Asp Asp Asp Met  Pro Lys Asn 
    1190                 1195                 1200             


Ala Asp  Ala Asn Gly Ala Tyr  His Ile Ala Leu Lys  Gly Leu Trp 
    1205                 1210                 1215             


Cys Leu  Glu Gln Ile Ser Lys  Thr Asp Asp Leu Lys  Lys Val Lys 
    1220                 1225                 1230             


Leu Ala  Ile Ser Asn Lys Glu  Trp Leu Glu Phe Val  Gln Thr Leu 
    1235                 1240                 1245             


Lys Gly  
    1250 


<210>  18
<211>  3987
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Cas12a polynucleotide

<400>  18
atggccggga gcaagaagcg ccggataaag caggacacgc agttcgaggg cttcaccaac       60

ctgtaccaag tctccaagac gctccggttc gagcttatcc cgcaagggaa gaccctgaaa      120

cacatccagg aacaaggttt catcgaggag gacaaggccc gcaacgacca ctacaaggag      180

ctcaagccca taatcgatcg gatctacaag acgtacgccg accagtgcct ccaactggtg      240

cagctcgact gggagaacct gagcgccgcc attgacagct accgcaagga aaagacggag      300

gagacgcgca acgcccttat tgaggagcaa gccacctacc gcaacgccat ccacgactac      360

ttcatcgggc gcaccgacaa cctgacggac gcgatcaaca agcgccacgc ggaaatctac      420

aagggccttt tcaaggccga gctcttcaac gggaaggtcc taaaacagct cgggactgtc      480

acgacaaccg agcatgagaa cgccctcctt cgcagcttcg acaagttcac cacatacttc      540

tcgggcttct accggaaccg caagaacgtt ttcagcgccg aggacatctc caccgccatc      600

ccgcacagga tcgtccagga caacttcccc aagttcaagg agaactgcca catcttcacg      660

cgcctgatta cagccgtacc ttcacttcgt gagcacttcg agaacgtcaa aaaggccatc      720

gggatcttcg tctccacgtc catcgaggag gtattctctt tcccgttcta taaccagctc      780

ctgacccaga cgcagatcga cctctacaac cagctactgg gcggcatcag ccgggaggcc      840

gggaccgaga aaataaaggg cctcaacgaa gttctcaacc tggccatcca gaagaacgac      900

gagaccgcgc atatcatcgc atccctgccg catcgcttca ttcctttgtt caagcagata      960

ttgagcgacc ggaacaccct ctcgttcatc ctcgaagaat tcaagagcga cgaggaggtc     1020

attcagtctt tctgcaagta caagacgctc ctacggaatg agaatgtgct ggagaccgcg     1080

gaggcactct tcaatgagct gaactccatt gacctgaccc acatcttcat tagccacaag     1140

aaactggaga cgatctccag cgccctgtgc gaccactggg acactctccg caacgccctc     1200

tacgaacgcc ggatctccga acttaccggc aagataacta agtcggctaa ggagaaggtg     1260

caacggagcc tcaagcacga ggacatcaac cttcaggaaa tcatctcagc cgcgggcaag     1320

gagctgagcg aggcgtttaa gcagaaaaca tcggagatac tgagccacgc gcacgcggcc     1380

ctggatcaac cgctgccgac gactctcaag aagcaagagg agaaggaaat ccttaagtcc     1440

cagctcgact cgctgctcgg cctctatcac ttgctcgact ggttcgcggt tgatgagtcc     1500

aacgaggtgg acccggagtt ctccgcgcgc ctcacgggta ttaagctgga gatggagcca     1560

agcttaagct tctacaacaa ggcccgcaac tacgcgacca aaaaaccgta ctcagtcgag     1620

aaattcaagc tgaatttcca gatgcctaca ttggcgaggg ggtgggacgt gaaccgcgag     1680

aagaacaatg gagccatcct gttcgtcaaa aatgggttgt actacctggg catcatgccc     1740

aagcagaagg gccgttacaa ggccctgtca ttcgagccta ccgagaagac ctcggagggc     1800

ttcgacaaga tgtactacga ctatttcccg gacgccgcca agatgatccc gaagtgctcc     1860

acgcagctca aagccgtcac ggcccacttc cagacgcata ccacgccgat acttctgagc     1920

aacaacttca ttgagccgct agagatcacg aaggagatat acgacctaaa caaccccgaa     1980

aaggagccca agaagttcca gacagcctac gctaagaaga caggtgatca gaagggatat     2040

agggaggcac tctgcaagtg gatcgacttc acgcgcgact tcctgtcgaa atatacaaag     2100

acgaccagca ttgacctaag ttctctccgc ccatcctccc agtacaagga tctgggcgag     2160

tattatgcgg agctgaaccc attgctgtac cacatcagct tccagaggat cgccgagaag     2220

gagattatgg acgcggtgga gacggggaaa ctatacctgt tccaaatata taacaaggac     2280

ttcgctaaag ggcaccacgg gaagcccaac ctgcacacac tctactggac gggcttgttt     2340

tcgccagaaa atttggccaa gacttcgatc aagctcaacg gccaggcgga gttgttttac     2400

cgtcccaagt ctcgcatgaa gcgcatggcg catcgcctcg gagagaaaat gcttaacaag     2460

aagctcaagg atcagaagac gcccatacct gatacgttgt accaggaatt gtacgactac     2520

gtgaaccacc gcctatcgca cgacctctca gacgaggccc gcgccctcct cccaaacgtg     2580

attactaagg aggtttccca tgaaataatc aaggaccgac ggttcaccag cgacaaattt     2640

tttttccacg tgcctatcac gctcaattac caggcggcca actccccatc gaagttcaac     2700

cagcgcgtga acgcctacct taaggagcac ccggagaccc caatcatcgg gatcgaccgt     2760

ggcgagcgga acctgatcta tattacggtg atcgatagca ccgggaagat cctggagcag     2820

cgctccctga acacaatcca gcagtttgac taccagaaga aactcgacaa ccgggagaag     2880

gagcgcgtcg cagcccggca agcatggagt gtggtcggca ccataaagga cctgaaacag     2940

ggttacctaa gtcaagttat ccacgagatc gttgacctga tgatacacta tcaagccgta     3000

gtcgtgctgg agaacctcaa cttcgggttt aagtccaagc gcaccggcat cgcggagaag     3060

gcggtgtacc agcagttcga gaagatgctg atcgacaagc tgaactgcct ggtgctcaag     3120

gactaccctg cggagaaggt cggcggggtc ttgaacccgt accagctaac cgaccagttc     3180

acgagcttcg ccaaaatggg cacgcagtcc ggattcttgt tttatgtccc ggctccatat     3240

acaagtaaga tcgacccgct gacagggttt gttgacccat tcgtgtggaa gaccatcaag     3300

aaccacgaga gcaggaaaca cttcttagag ggcttcgact tcctgcatta cgacgttaag     3360

acaggcgact tcatcctgca cttcaagatg aaccgcaacc tgtcgttcca gaggggcctg     3420

cccggcttca tgcccgcctg ggatatcgtc tttgagaaga atgagacgca gttcgacgcg     3480

aaggggacgc cgttcatcgc tggaaagcgg atcgtgccgg tcatcgagaa ccaccgcttc     3540

acgggtcgct accgagattt ataccccgcc aacgaactaa ttgcgctgct ggaggagaag     3600

gggatcgtgt tccgagatgg cagcaacatt ctcccgaagc tgctggagaa cgacgactcg     3660

cacgctattg acacgatggt cgccctcata cggagcgtgc ttcagatgcg gaacagtaac     3720

gctgccacgg gcgaggacta cattaactcc cccgtccgcg acctcaacgg ggtctgcttc     3780

gatagccgct tccagaaccc ggagtggcct atggatgcgg acgcgaacgg ggcctaccac     3840

atcgccctca agggccaact cctgctcaac cacttgaagg aaagcaaaga cctcaaattg     3900

cagaatggca tcagtaacca ggactggctc gcgtacatcc aggaactgag aaacgggtcc     3960

aagaagcggc gtatcaagca agattga                                         3987


<210>  19
<211>  3987
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Cas12a polynucleotide

<400>  19
atggcgggaa gcaaaaagcg ccggattaag caagacacgc agttcgaggg cttcacgaac       60

ctctaccaag tcagcaagac cctccggttc gagctgatac cacagggaaa gacgctcaag      120

cacatccagg aacagggctt catcgaggag gacaaggcgc gcaacgacca ctacaaggag      180

ttgaaaccga tcatcgaccg catctacaag acgtacgccg accagtgcct ccagctcgtg      240

cagctcgact gggagaacct ctccgccgcc attgactcgt accggaagga gaagactgag      300

gagacccgca acgccctgat cgaggagcaa gcaacctacc ggaacgccat ccacgactac      360

ttcatcggcc gcaccgacaa cctcaccgac gcgatcaaca agcggcacgc ggagatatac      420

aaagggctgt tcaaggcgga gctgttcaac ggcaaggtgc tcaagcagct agggacggtg      480

accacgaccg agcacgagaa cgcgctcctc cgcagcttcg acaagttcac cacctacttc      540

agcggcttct accggaaccg caagaatgtg ttcagcgcgg aggacatcag cacggccatc      600

ccgcaccgca tcgtccagga caacttcccg aagttcaagg agaactgcca catcttcacc      660

cgcctgataa ccgccgtccc ctccctgcgg gagcacttcg agaacgtcaa aaaggcaatt      720

gggatcttcg tctcgaccag cattgaggag gtgttcagct tccccttcta caaccagctc      780

ctcacccaga cgcagatcga cctgtacaat cagttgctcg gcgggataag ccgcgaggcg      840

ggaaccgaaa aaatcaaggg gctgaacgaa gtgttgaacc tcgccatcca gaagaacgac      900

gagaccgcgc acatcatcgc ctccctgccc caccggttca tcccgctgtt caagcagatc      960

ctctctgacc ggaacaccct gtccttcatt cttgaggagt tcaagtcgga cgaggaggtc     1020

atccagagct tctgcaagta caagacgctg ctacggaacg agaacgtgct ggagacggcg     1080

gaggcactgt tcaacgagct aaacagcatc gacctcacgc acatcttcat cagtcacaag     1140

aaactggaga ccatctcctc cgcgctgtgc gaccactggg acacgctcag gaacgcgctc     1200

tacgagcgcc gaatcagtga gctgacgggc aagatcacga agtccgcgaa ggagaaggtg     1260

cagcggtccc tcaagcacga ggacatcaac ctccaggaga tcatctcagc ggctgggaaa     1320

gagctgtccg aggcgttcaa gcagaaaacg agcgaaatcc tgtcccacgc gcacgcggcc     1380

ctggatcagc ctctgccgac gaccctcaag aaacaagaag aaaaggaaat cctcaagtcg     1440

cagctcgact cgctgctggg cctgtaccat ctcctcgact ggttcgccgt ggacgagagc     1500

aacgaggtgg accccgagtt ctccgcgcgg cttacgggga tcaagctgga gatggagccc     1560

agcctgtcct tctacaacaa ggcgcgcaac tacgccacca agaagcccta cagcgtggag     1620

aagttcaagc tcaacttcca gatgcccact ctcgcacgtg ggtgggacgt caaccgcgaa     1680

aaaaataatg gggcgatcct gttcgtcaag aacggcctgt actacttggg catcatgccg     1740

aaacagaagg gccgctacaa ggccctgagc ttcgaaccga ccgagaaaac gagcgagggg     1800

ttcgacaaga tgtactacga ctacttcccc gacgccgcga agatgattcc aaagtgctcc     1860

acgcagctta aggccgtgac ggcccacttc cagacgcaca cgaccccgat cctcctcagc     1920

aacaacttca tcgagcccct ggagatcacg aaggagatat acgacctgaa caacccggag     1980

aaggagccca agaaattcca gaccgcctac gccaagaaga caggcgacca aaagggttac     2040

agggaggccc tctgcaagtg gatcgacttc actagggact tcctgtccaa gtacaccaag     2100

actacctcta tcgacctgtc cagcctccgc ccgtcgtccc agtacaaaga tttgggcgag     2160

tattacgcgg agctgaaccc actgctctac cacatcagct tccagcgcat cgcggagaag     2220

gagatcatgg acgcagtgga gacgggcaag ctatacctat ttcagatata caacaaagac     2280

ttcgctaagg gacaccacgg caagcctaac ctgcacaccc tctactggac ggggctcttc     2340

agcccggaga acctcgccaa gacctcgatc aagctcaacg gccaggccga gctgttctac     2400

cggcccaagt cccgcatgaa gcggatggcc caccggctcg gggagaaaat gctcaacaag     2460

aaattgaagg accaaaaaac gccgataccc gacaccctat accaggagct gtacgactat     2520

gtgaaccacc gcctgagcca cgacctcagc gacgaggcgc gggccctcct gccgaacgtc     2580

atcacaaagg aggtcagcca cgagatcatc aaggaccggc gcttcacctc cgacaagttt     2640

ttctttcacg tgcccatcac gctcaactac caggccgcca actcgccgtc caagttcaac     2700

cagcgcgtga acgcctacct caaggagcac cccgagaccc cgatcatcgg gattgaccga     2760

ggggagcgga acctcatcta catcaccgtc atcgacagca ccgggaagat ccttgaacag     2820

cggtcgctca acaccatcca gcagttcgac taccagaaga aactcgacaa ccgggagaag     2880

gagagagtgg cggcccgcca ggcttggtcc gtcgtcggga cgattaagga cttgaaacaa     2940

ggttacctgt cgcaagtgat ccacgagatc gttgacctga tgatccacta ccaagccgtc     3000

gtggtcctgg agaacctcaa cttcggcttc aagagcaaac gaaccggcat cgcggagaag     3060

gccgtgtacc agcagttcga aaaaatgctg atcgacaagc tgaactgcct cgtgctcaag     3120

gactaccccg ctgagaaggt cggcggggtg ctgaacccgt accagctcac tgaccagttc     3180

accagcttcg caaagatggg cacccagtcc ggcttcctgt tctacgtgcc tgcgccatac     3240

acctcgaaga tcgacccgct caccgggttc gtggacccct tcgtctggaa gaccatcaag     3300

aaccacgaga gccgcaagca cttcctggag ggcttcgact tcctccacta cgacgtcaag     3360

accggggact tcatcctgca cttcaagatg aaccgcaacc tcagtttcca gcgcggcctg     3420

ccggggttca tgcccgcttg ggatatagtc ttcgagaaga atgagacgca gttcgacgcg     3480

aagggcaccc cgttcatcgc cgggaagcgc atcgtgccgg tcatcgagaa ccaccggttc     3540

accgggcgct accgcgacct atacccggcg aacgagttga tcgccctcct ggaggagaag     3600

ggcatcgtgt tccgcgacgg ctccaacatc ctcccgaagc tgctcgaaaa cgacgactcc     3660

cacgccatcg acacgatggt cgcgctgatc cggtcggtgc tccagatgcg gaactccaac     3720

gccgcgacgg gcgaggacta catcaacagt ccggtccgcg atctgaacgg cgtctgcttc     3780

gactcccggt tccagaaccc cgagtggccg atggacgcgg acgcgaacgg cgcataccac     3840

atcgccctaa aagggcaatt gctgctcaac cacctcaagg aatccaaaga cctaaagctc     3900

cagaacggca tctccaacca ggactggctg gcgtacatcc aggaactgcg gaacgggagc     3960

aaaaaacgtc ggatcaagca agattga                                         3987


<210>  20
<211>  3987
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic Cas12a polynucleotide

<400>  20
atggcgggct ccaagaaacg ccggattaag caagataccc agttcgaggg gttcacgaac       60

ctctaccaag tgagcaagac cctccgattc gaactgattc ctcaggggaa gaccctcaag      120

cacatccagg agcaagggtt catcgaggag gacaaggcgc ggaacgacca ctacaaggaa      180

ctcaaaccca tcatcgaccg catctacaag acctacgccg atcagtgcct ccagctcgtg      240

cagttggact gggagaacct cagcgcggcc attgactcct accggaagga gaaaacggag      300

gagacgcgca acgcgctcat cgaggaacag gcaacctatc gcaacgccat ccacgactac      360

ttcatcggga ggactgacaa cctcactgac gcgattaaca agcgccacgc ggagatatac      420

aagggactct tcaaagcgga gctgtttaac ggcaaggttc tcaagcaact cggcactgtg      480

accacgaccg agcatgagaa cgccctgctc cgctccttcg acaagttcac cacctacttc      540

tccgggttct accgcaaccg caagaatgtc ttcagcgcgg aggacatcag cacggccatt      600

ccacatcgaa tcgtccaaga taacttcccg aagttcaagg agaactgcca catcttcacc      660

cgactcatta ctgctgtacc gtcgttacgc gaacacttcg agaacgtcaa gaaggcaatt      720

ggaatcttcg tctctacgtc aatagaggag gtgttcagct tccctttcta caaccagctc      780

cttacgcaga cccagataga cctgtacaat cagctcctcg gtgggatcag ccgggaggcg      840

gggactgaga agattaaagg gctcaacgag gtcttgaacc tggccatcca aaaaaacgat      900

gagacggcgc acatcatcgc ctcgctgccc caccggttca tcccgctgtt caagcagatc      960

ctcagtgaca ggaacacctt gagctttatc ctagaggagt tcaagagcga cgaggaggtg     1020

atccagagct tctgcaagta caaaaccctg ctgaggaacg agaacgtcct ggagacggcg     1080

gaggcgctgt tcaacgagct gaactctatc gacttaactc acatattcat ctcgcacaag     1140

aagctggaga ctattagctc tgcactctgc gaccactggg acaccctccg caacgcgctc     1200

tacgagcgcc gcatctcgga gctgaccggg aagatcacca aatccgcgaa ggaaaaggtc     1260

cagcgttccc tcaaacacga ggatattaac ttacaggaga ttatctcagc ggctgggaag     1320

gagttgtcag aggcgttcaa gcagaaaact tccgagatcc tgagccacgc gcacgcagcg     1380

ctcgaccagc ctctgcccac caccctcaaa aagcaggaag aaaaagagat cctcaagagc     1440

cagttggact ccctgctggg gctctatcac cttctcgact ggttcgccgt cgatgagtcg     1500

aacgaggtgg accccgagtt ctccgcccgg ctgaccggca tcaagctaga gatggagccg     1560

tccctcagct tctacaataa ggcccgcaac tacgcgacca aaaaacccta cagcgtggag     1620

aagttcaagc tgaacttcca gatgccgacc ttagcacgcg gttgggacgt aaacagggag     1680

aagaacaatg gagccatcct gttcgtcaag aacgggcttt actacctcgg gataatgccc     1740

aagcagaagg gccgctacaa ggccctttcc ttcgagccga cggagaaaac ctccgagggg     1800

ttcgacaaga tgtactacga ctacttcccc gacgccgcca agatgatccc gaagtgctca     1860

acgcagctaa aagccgtgac cgcccacttc cagacccaca cgacgccgat cctgctgagc     1920

aacaacttca tcgagcccct tgagatcact aaggagatat acgacctgaa caaccccgag     1980

aaggagccca agaagtttca aaccgcctac gccaaaaaaa ctggcgacca aaagggctac     2040

agggaggcgc tgtgtaagtg gatcgacttc acacgcgact tcctttcgaa gtatacgaag     2100

acaacctcta ttgacctgag cagcctgcgt cctagctccc agtacaaaga tttgggcgag     2160

tactacgcgg agcttaatcc actactctac cacatctcat tccagcgcat cgctgagaag     2220

gaaatcatgg acgcggtgga gacaggcaaa ctgtacctct tccagatata caacaaagac     2280

ttcgctaagg ggcaccacgg gaagcccaac cttcatacgc tctactggac gggcctattc     2340

agccccgaaa atctggccaa gacctccatc aagctgaacg gccaagcgga gctgttctac     2400

agacccaaga gccggatgaa gcggatggcc cacaggctcg gcgagaaaat gcttaacaaa     2460

aagttgaagg accagaaaac ccctatcccc gacaccctct accaggaact gtacgactac     2520

gtgaaccaca ggctctcgca cgacctttcc gacgaggccc gtgccctact cccgaacgtc     2580

attaccaaag aggtttcgca cgagatcatc aaggaccggc ggttcacgag cgacaagttt     2640

ttctttcacg tccccatcac ccttaactac caggcggcca actccccatc caagttcaac     2700

cagcgtgtga atgcctacct caaggagcac ccagagaccc cgatcattgg gatcgaccgg     2760

ggcgagcgga acctgatcta catcaccgtc atcgactcga cgggcaagat tcttgagcag     2820

agatcgttga ataccataca gcagttcgac taccagaaga aactcgacaa ccgcgagaag     2880

gagcgcgtgg cggcccgcca ggcgtggtcc gtcgttggga cgattaagga cttgaaacaa     2940

ggttatctgt cccaagtcat ccacgagatc gttgatctga tgatccacta tcaggcagtg     3000

gtggtgctgg agaatctcaa cttcggcttc aagagtaagc ggacgggaat cgccgagaag     3060

gccgtgtacc agcagttcga gaagatgctg atcgacaagc tcaactgcct tgtgctgaaa     3120

gactacccgg ccgagaaggt cggcggcgtc ctcaacccgt accaacttac cgaccagttc     3180

acctccttcg ccaagatggg cactcagtcc gggttcttgt tctacgtccc cgcaccttac     3240

acctctaaga tcgaccctct gactggcttc gtagatccat tcgtgtggaa gaccattaag     3300

aaccacgaga gccgcaagca cttcctggag ggcttcgact tcctgcacta cgacgtgaag     3360

accggggact tcatccttca cttcaagatg aaccggaacc tcagcttcca gcggggcctg     3420

ccggggttca tgcccgcctg ggacatcgtg ttcgagaaga acgagaccca gttcgacgcg     3480

aagggcacgc ccttcatcgc cgggaagcgt atcgtgccgg tgatcgagaa ccatcgtttc     3540

acgggtcgct accgtgacct ctacccggcg aacgagctta tcgcactcct ggaggagaag     3600

ggcatcgtct tccgggacgg ctccaacatc ctcccgaaac tgctggaaaa cgacgactct     3660

cacgccatcg acacgatggt ggccctcatc cggtccgtgc tccaaatgcg gaacagcaac     3720

gccgccaccg gtgaggacta catcaacagc ccggtccggg atctgaacgg ggtgtgcttc     3780

gattcgcggt tccagaatcc tgagtggccg atggacgcgg atgcaaacgg ggcgtaccac     3840

atcgcgctca agggccagtt acttctgaac caccttaagg agtctaaaga tttgaaactc     3900

cagaacggga tctcgaacca ggactggctg gcctacatcc aagagttgcg gaacggcagc     3960

aagaagcggc ggattaagca agattag                                         3987


<210>  21
<211>  1592
<212>  DNA
<213>  Medicago truncatula

<400>  21
actgttaata atttttaaac gtcagcgcac taaaaaaacg aaaagacgga cacgtgaaaa       60

taaaaaacac acactagttt atgacgcaat actattttac ttatgatttg ggtacattag      120

acaaaaccgt gaaagagatg tatcagctat gaaacctgta tacttcaata cagagactta      180

ctcatatcgg atacgtacgc acgaagtatc atattaatta ttttaatttt taataaatat      240

tttatcggat acttatgtga tactctacat atacacaagg atatttctaa gatactttat      300

agatacgtat cctagaaaaa catgaagagt aaaaaagtga gacaatgttg taaaaattca      360

ttataaatgt atatgattca attttagata tgcatcagta taattgattc tcgatgaaac      420

acttaaaatt atatttcttg tggaagaacg tagcgagaga ggtgattcag ttagacaaca      480

ttaaataaaa ttaatgttaa gttcttttaa tgatgtttct ctcaatatca catcatatga      540

aaatgtaata tgatttataa gaaaattttt aaaaaattta ttttaataat cacatgtact      600

attttttaaa aattgtatct tttataataa tacaataata aagagtaatc agtgttaatt      660

tttcttcaaa tataagtttt attataaatc attgttaacg tatcataagt cattaccgta      720

tcgtatctta attttttttt aaaaaccgct aattcacgta cccgtattgt attgtacccg      780

cacctgtatc acaatcgatc ttagttagaa gaattgtctc gaggcggtgc aagacagcat      840

ataatagacg tggactctct tataccaaac gttgtcgtat cacaaagggt taggtaacaa      900

gtcacagttt gtccacgtgt cacgttttaa ttggaagagg tgccgttggc gtaatataac      960

agccaatcga tttttgctat aaaagcaaat caggtaaact aaacttcttc attcttttct     1020

tccccatcgc tacaaaaccg gttcctttgg aaaagagatt cattcaaacc tagcacccaa     1080

ttccgtttca aggtataatc tactttctat tcttcgatta ttttattatt attagctact     1140

atcgtttaat cgatcttttc ttttgatccg tcaaatttaa attcaattag ggttttgttc     1200

ttttctttca tctgattgaa atccttctga attgaaccgt ttacttgatt ttactgttta     1260

ttgtatgatt taatcctttg tttttcaaag acagtcttta gattgtgatt aggggttcat     1320

ataaattttt agatttggat ttttgtattg tatgattcaa aaaatacgtc ctttaattag     1380

attagtacat ggatattttt tacccgattt attgattgtc agggagaatt tgatgagcaa     1440

gtttttttga tgtctgttgt aaattgaatt gattataatt gctgatctgc tgcttccagt     1500

tttcataacc catattcttt taaccttgtt gtacacacaa tgaaaaattg gtgattgatt     1560

catttgtttt tctttgtttt ggattataca gg                                   1592


<210>  22
<211>  2000
<212>  DNA
<213>  Zea mays

<400>  22
gtcgtgcccc tctctagaga taaagagcat tgcatgtcta aagtataaaa aattaccaca       60

tatttttttg tcacacttat ttgaagtgta gtttatctat ctctatacat atatttaaac      120

ttcactctac aaataatata gtctataata ctaaaataat attagtgttt tagaggatca      180

tataaataaa ctgctagaca tggtctaaag gataattgaa tattttgaca atctacagtt      240

ttatcttttt agtgtgcatg tgatctctct gttttttttg caaatagctt gacctatata      300

atacttcatc cattttatta gtacatccat ttaggattta gggttgatgg tttctataga      360

ctaattttta gtacatccat tttattcttt ttagtctcta aattttttaa aactaaaact      420

ctattttagt tttttattta ataatttaga tataaaatga aataaaataa attgactaca      480

aataaaacaa atacccttta agaaataaaa aaactaagca aacatttttc ttgtttcgag      540

tagataatga caggctgttc aacgccgtcg acgagtctaa cggacaccaa ccagcgaacc      600

agcagcgtcg cgtcgggcca agcgaagcag acggcacggc atctctgtag ctgcctctgg      660

acccctctcg agagttccgc tccaccgttg gacttgctcc gctgtcggca tccagaaatt      720

gcgtggcgga gcggcagacg tgaggcggca cggcaggcgg cctcttcctc ctctcacggc      780

accggcagct acgggggatt cctttcccac cgctccttcg ctttcccttc ctcgcccgcc      840

gtaataaata gacaccccct ccacaccctc tttccccaac ctcgtgttcg ttcggagcgc      900

acacacacgc aaccagatct cccccaaatc cagccgtcgg cacctccgct tcaaggtacg      960

ccgctcatcc tccccccccc cctctctcta ccttctctag atcggcgatc cggtccatgg     1020

ttagggcccg gtagttctac ttctgttcat gtttgtgtta gagcaaacat gttcatgttc     1080

atgtttgtga tgatgtggtc tggttgggcg gtcgttctag atcggagtag gatactgttt     1140

caagctacct ggtggattta ttaattttgt atctgtatgt gtgtgccata catcttcata     1200

gttacgagtt taagatgatg gatggaaata tcgatctagg ataggtatac atgttgatgc     1260

gggttttact gatgcatata cagagatgct ttttttctcg cttggttgtg atgatatggt     1320

ctggttgggc ggtcgttcta gatcggagta gaatactgtt tcaaactacc tggtggattt     1380

attaaaggat aaagggtcgt tctagatcgg agtagaatac tgtttcaaac tacctggtgg     1440

atttattaaa ggatctgtat gtatgtgcct acatcttcat agttacgagt ttaagatgat     1500

ggatggaaat atcgatctag gataggtata catgttgatg cgggttttac tgatgcatat     1560

acagagatgc tttttttcgc ttggttgtga tgatgtggtc tggttgggcg gtcgttctag     1620

atcggagtag aatactgttt caaactacct ggtggattta ttaattttgt atctttatgt     1680

gtgtgccata catcttcata gttacgagtt taagatgatg gatggaaata ttgatctagg     1740

ataggtatac atgttgatgt gggttttact gatgcatata catgatggca tatgcggcat     1800

ctattcatat gctctaacct tgagtaccta tctattataa taaacaagta tgttttataa     1860

ttattttgat cttgatatac ttggatgatg gcatatgcag cagctatatg tggatttttt     1920

agccctgcct tcatacgcta tttatttgct tggtactgtt tcttttgtcc gatgctcacc     1980

ctgttgtttg gtgatacttc                                                 2000


<210>  23
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic GCN4 sequence

<400>  23

Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala Arg 
1               5                   10                  15      


Leu Lys Lys Gly Ser Gly Ser Gly 
            20                  


<210>  24
<211>  241
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic GCN4 sequence

<400>  24

Glu Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
1               5                   10                  15      


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
            20                  25                  30          


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
        35                  40                  45              


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
    50                  55                  60                  


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
65                  70                  75                  80  


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
                85                  90                  95      


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
            100                 105                 110         


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
        115                 120                 125             


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
    130                 135                 140                 


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
145                 150                 155                 160 


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
                165                 170                 175     


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
            180                 185                 190         


Gly Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu Asn Glu Val Ala 
        195                 200                 205             


Arg Leu Lys Lys Gly Ser Gly Ser Gly Glu Glu Leu Leu Ser Lys Asn 
    210                 215                 220                 


Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Gly Ser Gly Ser 
225                 230                 235                 240 


Gly 
    


<210>  25
<211>  277
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic ScFv antibody

<400>  25

Met Gly Pro Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Thr Gly Ala 
            20                  25                  30          


Val Thr Thr Ser Asn Tyr Ala Ser Trp Val Gln Glu Lys Pro Gly Lys 
        35                  40                  45              


Leu Phe Lys Gly Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Leu Ile Gly Asp Lys Ala Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala Leu 
                85                  90                  95      


Trp Tyr Ser Asn His Trp Val Phe Gly Gln Gly Thr Lys Val Glu Leu 
            100                 105                 110         


Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Ser Gly Gly Gly Ser Glu Val Lys Leu Leu Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Val Ser Gly 
145                 150                 155                 160 


Phe Ser Leu Thr Asp Tyr Gly Val Asn Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Arg Gly Leu Glu Trp Ile Gly Val Ile Trp Gly Asp Gly Ile Thr Asp 
            180                 185                 190         


Tyr Asn Ser Ala Leu Lys Asp Arg Phe Ile Ile Ser Lys Asp Asn Gly 
        195                 200                 205             


Lys Asn Thr Val Tyr Leu Gln Met Ser Lys Val Arg Ser Asp Asp Thr 
    210                 215                 220                 


Ala Leu Tyr Tyr Cys Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                245                 250                 255     


Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser 
        275         


<210>  26
<211>  66
<212>  DNA
<213>  Saccharomyces bayanus

<400>  26
ttcttgtcgt acttatagat cgctacgtta tttcaatttt gaaaatctga gtcctgggag       60

tgcgga                                                                  66


<210>  27
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser 
                85                  90                  95      


Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly 
            100                 105                 110         


Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln 
        115                 120                 125             


Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser 
    130                 135                 140                 


Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys 
145                 150                 155                 160 


Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His 
                165                 170                 175     


Gly Asn Asp Ser Thr Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp 
            180                 185                 190         


Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro 
        195                 200                 205             


Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala 
    210                 215                 220                 


Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu 
                245                 250                 255     


Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly 
            260                 265                 270         


Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu 
        275                 280                 285             


Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn 
    290                 295                 300                 


Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln 
305                 310                 315                 320 


Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu 
                325                 330                 335     


Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro 
            340                 345                 350         


Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val 
        355                 360                 365             


Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala 
    370                 375                 380                 


Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr 
385                 390                 395                 400 


Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln 
                405                 410                 415     


Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe 
            420                 425                 430         


Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe 
        435                 440                 445             


Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala 
    450                 455                 460                 


Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn 
465                 470                 475                 480 


Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp 
                485                 490                 495     


Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu 
            500                 505                 510         


Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu 
        515                 520                 525             


Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys 
    530                 535                 540                 


His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe 
                565                 570                 575     


Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser 
            580                 585                 590         


Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln 
        595                 600                 605             


Asp 
    


<210>  28
<211>  482
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  28

Met Val Arg Ser Gly Asn Lys Ala Ala Trp Leu Cys Met Asp Val Gly 
1               5                   10                  15      


Phe Thr Met Ser Asn Ser Ile Pro Gly Ile Glu Ser Pro Phe Glu Gln 
            20                  25                  30          


Ala Lys Lys Val Ile Thr Met Phe Val Gln Arg Gln Val Phe Ala Glu 
        35                  40                  45              


Asn Lys Asp Glu Ile Ala Leu Val Leu Phe Gly Thr Asp Gly Thr Asp 
    50                  55                  60                  


Asn Pro Leu Ser Gly Gly Asp Gln Tyr Gln Asn Ile Thr Val His Arg 
65                  70                  75                  80  


His Leu Met Leu Pro Asp Phe Asp Leu Leu Glu Asp Ile Glu Ser Lys 
                85                  90                  95      


Ile Gln Pro Gly Ser Gln Gln Ala Asp Phe Leu Asp Ala Leu Ile Val 
            100                 105                 110         


Ser Met Asp Val Ile Gln His Glu Thr Ile Gly Lys Lys Phe Glu Lys 
        115                 120                 125             


Arg His Ile Glu Ile Phe Thr Asp Leu Ser Ser Arg Phe Ser Lys Ser 
    130                 135                 140                 


Gln Leu Asp Ile Ile Ile His Ser Leu Lys Lys Cys Asp Ile Ser Glu 
145                 150                 155                 160 


Arg His Ser Ile His Trp Pro Cys Arg Leu Thr Ile Gly Ser Asn Leu 
                165                 170                 175     


Ser Ile Arg Ile Ala Ala Tyr Lys Ser Ile Leu Gln Glu Arg Val Lys 
            180                 185                 190         


Lys Thr Thr Trp Asp Ala Lys Thr Leu Lys Lys Glu Asp Ile Gln Lys 
        195                 200                 205             


Glu Thr Val Tyr Cys Leu Asn Asp Asp Asp Glu Thr Glu Val Leu Lys 
    210                 215                 220                 


Glu Asp Ile Ile Gln Gly Phe Arg Tyr Gly Ser Asp Ile Val Pro Phe 
225                 230                 235                 240 


Ser Lys Val Asp Glu Glu Gln Met Lys Tyr Lys Ser Glu Gly Lys Cys 
                245                 250                 255     


Phe Ser Val Leu Gly Phe Cys Lys Ser Ser Gln Val Gln Arg Arg Phe 
            260                 265                 270         


Phe Met Gly Asn Gln Val Leu Lys Val Phe Ala Ala Arg Asp Asp Glu 
        275                 280                 285             


Ala Ala Ala Val Ala Leu Ser Ser Leu Ile His Ala Leu Asp Asp Leu 
    290                 295                 300                 


Asp Ile Trp Ala Ile Val Arg Tyr Ala Tyr Asp Lys Arg Ala Asn Pro 
305                 310                 315                 320 


Gln Val Gly Val Ala Phe Pro His Ile Lys His Asn Tyr Glu Cys Leu 
                325                 330                 335     


Val Tyr Val Gln Leu Pro Phe Met Glu Asp Leu Arg Gln Tyr Met Phe 
            340                 345                 350         


Ser Ser Leu Lys Asn Ser Lys Lys Tyr Ala Pro Thr Glu Ala Gln Leu 
        355                 360                 365             


Asn Ala Val Asp Ala Leu Ile Asp Ser Met Ser Leu Ala Lys Lys Asp 
    370                 375                 380                 


Glu Lys Thr Asp Thr Leu Glu Asp Leu Phe Pro Thr Thr Lys Ile Pro 
385                 390                 395                 400 


Asn Pro Arg Phe Gln Arg Leu Phe Gln Cys Leu Leu His Arg Ala Leu 
                405                 410                 415     


His Pro Arg Glu Pro Leu Pro Pro Ile Gln Gln His Ile Trp Asn Met 
            420                 425                 430         


Leu Asn Pro Pro Ala Glu Val Thr Thr Lys Ser Gln Ile Pro Leu Ser 
        435                 440                 445             


Lys Ile Lys Thr Leu Phe Pro Leu Ile Glu Ala Lys Lys Lys Asp Gln 
    450                 455                 460                 


Val Thr Ala Gln Glu Ile Phe Gln Asp Asn His Glu Asp Gly Pro Thr 
465                 470                 475                 480 


Ala Lys 
        


<210>  29
<211>  10
<212>  DNA
<213>  Methanobacterium thermoautotrophicum

<400>  29
aatttttgga                                                              10


<210>  30
<211>  83
<212>  PRT
<213>  Methanobacterium thermoautotrophicum

<400>  30

Gly Ser Val Ile Asp Val Ser Ser Gln Arg Val Asn Val Gln Arg Pro 
1               5                   10                  15      


Leu Asp Ala Leu Gly Asn Ser Leu Asn Ser Pro Val Ile Ile Lys Leu 
            20                  25                  30          


Lys Gly Asp Arg Glu Phe Arg Gly Val Leu Lys Ser Phe Asp Leu His 
        35                  40                  45              


Met Asn Leu Val Leu Asn Asp Ala Glu Glu Leu Glu Asp Gly Glu Val 
    50                  55                  60                  


Thr Arg Arg Leu Gly Thr Val Leu Ile Arg Gly Asp Asn Ile Val Tyr 
65                  70                  75                  80  


Ile Ser Pro 
            


<210>  31
<211>  25
<212>  DNA
<213>  Escherichia virus MS2

<400>  31
gcgcacatga ggatcaccca tgtgc                                             25


<210>  32
<211>  116
<212>  PRT
<213>  Escherichia virus MS2

<400>  32

Met Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr 
1               5                   10                  15      


Gly Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Ile Ala Glu 
            20                  25                  30          


Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val 
        35                  40                  45              


Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val 
    50                  55                  60                  


Pro Lys Gly Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro 
65                  70                  75                  80  


Ile Phe Ala Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln 
                85                  90                  95      


Gly Leu Leu Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn 
            100                 105                 110         


Ser Gly Ile Tyr 
        115     


<210>  33
<211>  26
<212>  DNA
<213>  Bacteriophage PP7

<400>  33
ataaggagtt tatatggaaa ccctta                                            26


<210>  34
<211>  127
<212>  PRT
<213>  Bacteriophage PP7

<400>  34

Met Ser Lys Thr Ile Val Leu Ser Val Gly Glu Ala Thr Arg Thr Leu 
1               5                   10                  15      


Thr Glu Ile Gln Ser Thr Ala Asp Arg Gln Ile Phe Glu Glu Lys Val 
            20                  25                  30          


Gly Pro Leu Val Gly Arg Leu Arg Leu Thr Ala Ser Leu Arg Gln Asn 
        35                  40                  45              


Gly Ala Lys Thr Ala Tyr Arg Val Asn Leu Lys Leu Asp Gln Ala Asp 
    50                  55                  60                  


Trp Asp Cys Ser Thr Ser Val Cys Gly Glu Leu Pro Lys Val Arg Tyr 
65                  70                  75                  80  


Thr Gln Val Trp Ser His Asp Val Thr Ile Val Ala Asn Ser Thr Glu 
                85                  90                  95      


Ala Ser Arg Lys Ser Leu Tyr Asp Leu Thr Lys Ser Leu Val Ala Thr 
            100                 105                 110         


Ser Gln Val Glu Asp Leu Val Val Asn Leu Val Pro Leu Gly Arg 
        115                 120                 125         


<210>  35
<211>  19
<212>  DNA
<213>  Unknown

<220>
<223>  Shigella virus

<400>  35
ctgaatgcct gcgagcatc                                                    19


<210>  36
<211>  62
<212>  PRT
<213>  Unknown

<220>
<223>  Shigella virus

<400>  36

Met Lys Ser Ile Arg Cys Lys Asn Cys Asn Lys Leu Leu Phe Lys Ala 
1               5                   10                  15      


Asp Ser Phe Asp His Ile Glu Ile Arg Cys Pro Arg Cys Lys Arg His 
            20                  25                  30          


Ile Ile Met Leu Asn Ala Cys Glu His Pro Thr Glu Lys His Cys Gly 
        35                  40                  45              


Lys Arg Glu Lys Ile Thr His Ser Asp Glu Thr Val Arg Tyr 
    50                  55                  60          


<210>  37
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  37

Arg Val Leu Tyr Val Gly Gly Leu Ala Glu Glu Val Asp Asp Lys Val 
1               5                   10                  15      


Leu His Ala Ala Phe Ile Pro Phe Gly Asp Ile Thr Asp Ile Gln Ile 
            20                  25                  30          


Pro Leu Asp Tyr Glu Thr Glu Lys His Arg Gly Phe Ala Phe Val Glu 
        35                  40                  45              


Phe Glu Leu Ala Glu Asp Ala Ala Ala Ala Ile Asp Asn Met Asn Glu 
    50                  55                  60                  


Ser Glu Leu Phe Gly Arg Thr Ile Arg Val Asn Leu Ala Lys Pro 
65                  70                  75                  


<210>  38
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  38

Arg Ser Ile Tyr Val Gly Asn Val Asp Tyr Gly Ala Thr Ala Glu Glu 
1               5                   10                  15      


Leu Glu Ala His Phe His Gly Cys Gly Ser Val Asn Arg Val Thr Ile 
            20                  25                  30          


Leu Cys Asp Lys Phe Ser Gly His Pro Lys Gly Phe Ala Tyr Ile Glu 
        35                  40                  45              


Phe Ser Asp Lys Glu Ser Val Arg Thr Ser Leu Ala Leu Asp Glu Ser 
    50                  55                  60                  


Leu Phe Arg Gly Arg Gln Ile Lys Val Ile Pro Lys Arg Thr 
65                  70                  75              


<210>  39
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  39

Asn Trp Leu Val Leu Lys Asn Leu Thr Pro Gln Ile Asp Gly Ser Thr 
1               5                   10                  15      


Leu Arg Thr Leu Cys Met Gln His Gly Pro Leu Ile Thr Phe His Leu 
            20                  25                  30          


Asn Leu Pro His Gly Asn Ala Leu Val Arg Tyr Ser Ser Lys Glu Glu 
        35                  40                  45              


Val Val Lys Ala Gln Lys Ser Leu His Met Cys Val Leu Gly Asn Thr 
    50                  55                  60                  


Thr Ile Leu Ala Glu Phe Ala Ser Glu 
65                  70              


<210>  40
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Lys Leu Phe Val Gly Gly Leu Ser Phe Asp Thr Asn Glu Gln Ser 
1               5                   10                  15      


Leu Glu Gln Val Phe Ser Lys Tyr Gly Gln Ile Ser Glu Val Val Val 
            20                  25                  30          


Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly Phe Gly Phe Val Thr 
        35                  40                  45              


Phe Glu Asn Ile Asp Asp Ala Lys Asp Ala Met Met Ala Met Asn Gly 
    50                  55                  60                  


Lys Ser Val Asp Gly Arg Gln Ile Arg Val Asp Gln Ala Gly Lys 
65                  70                  75                  


<210>  41
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  41

Leu Ile Pro Val Lys Gln Tyr Pro Lys Phe Asn Phe Val Gly Lys Leu 
1               5                   10                  15      


Leu Gly Pro Arg Gly Asn Ser Leu Lys Arg Leu Gln Glu Glu Thr Gly 
            20                  25                  30          


Ala Lys Met Ser Ile Leu Gly Lys Gly Ser Met Arg Asp Lys Ala Lys 
        35                  40                  45              


Glu Glu Glu Leu Arg Lys Ser Gly Glu Ala Lys Tyr Ala His Leu Ser 
    50                  55                  60                  


Asp Glu Leu His Val Leu Ile Ser Glu Gln 
65                  70                  


<210>  42
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  42

Leu Ile Pro Val Lys Gln Phe Pro Lys Phe Asn Phe Val Gly Lys Leu 
1               5                   10                  15      


Leu Gly Pro Arg Gly Asn Ser Leu Lys Arg Leu Gln Glu Glu Thr Leu 
            20                  25                  30          


Thr Lys Met Ser Ile Leu Gly Lys Gly Ser Met Arg Asp Lys Ala Lys 
        35                  40                  45              


Glu Glu Glu Leu Arg Lys Ser Gly Glu Ala Lys Tyr Phe His Leu Asn 
    50                  55                  60                  


Asp Asp Leu 
65          


<210>  43
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  43

Pro Glu Val Phe Gln Val Gln Thr Arg Leu Leu Lys Ala Ile Phe Gly 
1               5                   10                  15      


Pro Asp Gly Ser Arg Ile Pro Tyr Ile Glu Gln Val Ser Lys Ala Met 
            20                  25                  30          


Leu Glu Leu Lys Ala Leu Glu Ser Ser Asp Leu Thr Glu Val Val Val 
        35                  40                  45              


Tyr Gly Ser Tyr Leu Tyr Lys Leu Arg Thr Lys Trp Met Leu 
    50                  55                  60          


<210>  44
<211>  71
<212>  PRT
<213>  Mus musculus

<400>  44

Gln Val Leu Gly Thr Val Lys Trp Phe Asn Val Arg Asn Gly Tyr Gly 
1               5                   10                  15      


Phe Ile Asn Arg Asn Asp Thr Lys Glu Asp Val Phe Val His Gln Thr 
            20                  25                  30          


Ala Ile Lys Arg Asn Asn Pro Arg Lys Phe Leu Arg Ser Val Gly Asp 
        35                  40                  45              


Gly Glu Thr Val Glu Phe Asp Val Val Glu Gly Glu Lys Gly Ala Arg 
    50                  55                  60                  


Ala Ala Asn Val Thr Gly Pro 
65                  70      


<210>  45
<211>  71
<212>  PRT
<213>  Mus musculus

<400>  45

Lys Val Leu Gly Thr Val Lys Trp Phe Asn Val Arg Asn Gly Tyr Gly 
1               5                   10                  15      


Phe Ile Asn Arg Asn Asp Thr Lys Glu Asp Val Phe Val His Gln Thr 
            20                  25                  30          


Ala Ile Lys Lys Asn Asn Pro Arg Lys Tyr Leu Arg Ser Val Gly Asp 
        35                  40                  45              


Gly Glu Thr Val Glu Phe Asp Val Val Glu Gly Glu Lys Gly Ala Glu 
    50                  55                  60                  


Ala Ala Asn Val Thr Gly Pro 
65                  70      


<210>  46
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  46

Ala Arg Phe Phe Leu Ile Lys Ser Asn Asn His Glu Asn Val Ser Leu 
1               5                   10                  15      


Ala Lys Ala Lys Gly Val Trp Ser Thr Leu Pro Val Asn Glu Lys Lys 
            20                  25                  30          


Leu Asn Leu Ala Phe Arg Ser Ala Arg Ser Val Ile Leu Ile Phe Ser 
        35                  40                  45              


Val Arg Glu Ser Gly Lys Phe Gln Gly Phe Ala Arg Leu Ser Ser Glu 
    50                  55                  60                  


Ser His His Gly Gly Ser Pro Ile His Trp Val Leu Pro Ala Gly Met 
65                  70                  75                  80  


Ser Ala Lys Met Leu Gly Gly Val Phe Lys Ile Asp Trp Ile Cys Arg 
                85                  90                  95      


Arg Glu Leu Pro Phe Thr Lys Ser Ala His Leu Thr Asn Pro Trp Asn 
            100                 105                 110         


Glu His Lys Pro Val Lys Ile Gly Arg Asp Gly Gln Glu Ile Glu Leu 
        115                 120                 125             


Glu Cys Gly Thr Gln Leu Cys Leu Leu Phe 
    130                 135             


<210>  47
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Arg Ser Arg Leu Leu Glu Asp Phe Arg Asn Asn Arg Phe Pro Asn 
1               5                   10                  15      


Leu Gln Leu Arg Asp Leu Ile Gly His Ile Val Glu Phe Ser Gln Asp 
            20                  25                  30          


Gln His Gly Ser Arg Phe Ile Gln Gln Lys Leu Glu Arg Ala Thr Pro 
        35                  40                  45              


Ala Glu Arg Gln Met Val Phe Asn Glu Ile Leu Gln Ala Ala Tyr Gln 
    50                  55                  60                  


Leu Met Thr Asp Val Phe Gly Asn Tyr Val Ile Gln Lys Phe Phe Glu 
65                  70                  75                  80  


Phe Gly Ser Leu Asp Gln Lys Leu Ala Leu Ala Thr Arg Ile Arg Gly 
                85                  90                  95      


His Val Leu Pro Leu Ala Leu Gln Met Tyr Gly Cys Arg Val Ile Gln 
            100                 105                 110         


Lys Ala Leu Glu Ser Ile Ser Ser Asp Gln Gln Val Ile Ser Glu Met 
        115                 120                 125             


Val Lys Glu Leu Asp Gly His Val Leu Lys Cys Val Lys Asp Gln Asn 
    130                 135                 140                 


Gly Asn His Val Val Gln Lys Cys Ile Glu Cys Val Gln Pro Gln Ser 
145                 150                 155                 160 


Leu Gln Phe Ile Ile Asp Ala Phe Lys Gly Gln Val Phe Val Leu Ser 
                165                 170                 175     


Thr His Pro Tyr Gly Cys Arg Val Ile Gln Arg Ile Leu Glu His Cys 
            180                 185                 190         


Thr Ala Glu Gln Thr Leu Pro Ile Leu Glu Glu Leu His Gln His Thr 
        195                 200                 205             


Glu Gln Leu Val Gln Asp Gln Tyr Gly Asn Tyr Val Ile Gln His Val 
    210                 215                 220                 


Leu Glu His Gly Arg Pro Glu Asp Lys Ser Lys Ile Val Ser Glu Ile 
225                 230                 235                 240 


Arg Gly Lys Val Leu Ala Leu Ser Gln His Lys Phe Ala Ser Asn Val 
                245                 250                 255     


Val Glu Lys Cys Val Thr His Ala Ser Arg Ala Glu Arg Ala Leu Leu 
            260                 265                 270         


Ile Asp Glu Val Cys Cys Gln Asn Asp Gly Pro His Ser Ala Leu Tyr 
        275                 280                 285             


Thr Met Met Lys Asp Gln Tyr Ala Asn Tyr Val Val Gln Lys Met Ile 
    290                 295                 300                 


Asp Met Ala Glu Pro Ala Gln Arg Lys Ile Ile Met His Lys Ile Arg 
305                 310                 315                 320 


Pro His Ile Thr Thr Leu Arg Lys Tyr Thr Tyr Gly Lys His Ile Leu 
                325                 330                 335     


Ala Lys Leu Glu Lys Tyr Tyr 
            340             


<210>  48
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  48

Phe Phe Cys Asp Thr Cys Asp Arg Gly Phe Lys Asn Gln Glu Lys Tyr 
1               5                   10                  15      


Asp Lys His Met Ser Glu His 
            20              


<210>  49
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  49

Cys Gln Met Cys Gln Lys Gln Cys Arg Asp Glu Asn Gly Phe Lys Cys 
1               5                   10                  15      


His Cys Met Ser Glu Ser His 
            20              


<210>  50
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  50

Thr Ser Leu Lys Val Asp Asn Leu Thr Tyr Arg Thr Ser Pro Asp Thr 
1               5                   10                  15      


Leu Arg Arg Val Phe Glu Lys Tyr Gly Arg Val Gly Asp Val Tyr Ile 
            20                  25                  30          


Pro Arg Asp Arg Tyr Thr Lys Glu Ser Arg Gly Phe Ala Phe Val Arg 
        35                  40                  45              


Phe His Asp Lys Arg Asp Ala Glu Asp Ala Met Asp Ala Met Asp Gly 
    50                  55                  60                  


Ala Val Leu Asp Gly Arg Glu Leu Arg Val Gln Met Ala Arg Tyr 
65                  70                  75                  


<210>  51
<211>  84
<212>  PRT
<213>  Drosophila melanogaster

<400>  51

Gln Leu Phe Leu Gly Asn Ile Pro His His Ala Ser Glu Asp Asp Leu 
1               5                   10                  15      


Arg Glu Ile Phe Ser Arg Phe Gly Asn Val Leu Glu Leu Arg Ile Leu 
            20                  25                  30          


Ser Lys Ala Gly Asn Lys Val Pro Pro Gly Met Arg Ser Pro Leu Asn 
        35                  40                  45              


Tyr Gly Phe Ile Thr Tyr Asp Asp Pro Glu Ala Val Gln Lys Cys Leu 
    50                  55                  60                  


Ala Asn Cys Pro Leu Tyr Phe Pro Glu Asn Ser Pro Asp Gly Gln Lys 
65                  70                  75                  80  


Leu Asn Val Glu 
                


<210>  52
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Lys Leu Phe Val Gly Gly Leu Asn Phe Asn Thr Asp Glu Gln Ala 
1               5                   10                  15      


Leu Glu Asp His Phe Ser Ser Phe Gly Pro Ile Ser Glu Val Val Val 
            20                  25                  30          


Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly Phe Gly Phe Ile Thr 
        35                  40                  45              


Phe Thr Asn Pro Glu His Ala Ser Val Ala Met Arg Ala Met Asn Gly 
    50                  55                  60                  


Glu Ser Leu Asp Gly Arg Gln Ile Arg Val Asp His Ala Gly Lys 
65                  70                  75                  


<210>  53
<211>  683
<212>  PRT
<213>  Moloney murine leukemia virus

<400>  53

Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile 
            660                 665                 670         


Glu Asn Ser Ser Pro Asn Ser Arg Leu Ile Asn 
        675                 680             


<210>  54
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic RNA  spacer


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  wherein n is A, C, T or G

<400>  54
nnnnnnnnnn nnnnnnnnn                                                    19


<210>  55
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic target strand


<220>
<221>  misc_feature
<222>  (4)..(22)
<223>  wherein n is A, C, T or G

<400>  55
aaannnnnnn nnnnnnnnnn nn                                                22


<210>  56
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic non-target strand


<220>
<221>  misc_feature
<222>  (4)..(22)
<223>  wherein n is A, C, T or G

<400>  56
tttnnnnnnn nnnnnnnnnn nn                                                22


<210>  57
<211>  3790
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  57
ccatgggcag caaactggaa aaatttacga attgttatag cctgtccaag accctgcgtt       60

tcaaagccat ccccgttggc aaaacccagg agaatattga taataaacgt ctgctggttg      120

aggatgaaaa aagagcagaa gactataagg gagtcaaaaa actgctggat cggtactacc      180

tgagctttat aaatgacgtg ctgcatagca ttaaactgaa aaatctgaat aactatatta      240

gtctgttccg caagaaaacc cgaacagaga aagaaaataa agagctggaa aacctggaga      300

tcaatctgcg taaagagatc gcaaaagctt ttaaaggaaa tgaaggttat aaaagcctgt      360

tcaaaaaaga cattattgaa accatcctgc cggaatttct ggatgataaa gacgagatag      420

cgctcgtgaa cagcttcaac gggttcacga ccgccttcac gggctttttc gataacaggg      480

aaaatatgtt ttcagaggaa gccaaaagca cctcgatagc gttccgttgc attaatgaaa      540

atttgacaag atatatcagc aacatggata ttttcgagaa agttgatgcg atctttgaca      600

aacatgaagt gcaggagatt aaggaaaaaa ttctgaacag cgattatgat gttgaggatt      660

ttttcgaggg ggaatttttt aactttgtac tgacacagga aggtatagat gtgtataatg      720

ctattatcgg cgggttcgtt accgaatccg gcgagaaaat taagggtctg aatgagtaca      780

tcaatctgta taaccaaaag accaaacaga aactgccaaa attcaaaccg ctgtacaagc      840

aagtcctgag cgatcgggaa agcttgagct tttacggtga aggttatacc agcgacgagg      900

aggtactgga ggtctttcgc aataccctga acaagaacag cgaaattttc agctccatta      960

aaaagctgga gaaactgttt aagaattttg acgagtacag cagcgcaggt atttttgtga     1020

agaacggacc tgccataagc accattagca aggatatttt tggagagtgg aatgttatcc     1080

gtgataaatg gaacgcggaa tatgatgaca tacacctgaa aaagaaggct gtggtaactg     1140

agaaatatga agacgatcgc cgcaaaagct ttaaaaaaat cggcagcttt agcctggagc     1200

agctgcagga atatgcggac gccgacctga gcgtggtcga gaaactgaag gaaattatta     1260

tccaaaaagt ggatgagatt tacaaggtat atggtagcag cgaaaaactg tttgatgcgg     1320

acttcgttct ggaaaaaagc ctgaaaaaaa atgatgctgt tgttgcgatc atgaaagacc     1380

tgctcgatag cgttaagagc tttgaaaatt acattaaagc attctttggc gagggcaaag     1440

aaacaaacag agacgaaagc ttttatggcg acttcgtcct ggcttatgac atcctgttga     1500

aggtagatca tatatatgat gcaattcgta attacgtaac ccaaaagccg tacagcaaag     1560

ataagttcaa actgtatttc cagaacccgc agtttatggg tggctgggac aaagacaagg     1620

agacagacta tcgcgccact attctgcgtt acggcagcaa gtactatctc gccatcatgg     1680

acaaaaaata tgcaaagtgt ctgcagaaaa tcgataaaga cgacgtgaac ggaaattacg     1740

aaaagattaa ttataagctg ctgccagggc ccaacaagat gttaccgaaa gtattttttt     1800

ccaaaaaatg gatggcatac tataacccga gcgaggatat acagaagatt tacaaaaatg     1860

ggaccttcaa aaagggggat atgttcaatc tgaatgactg ccacaaactg atcgattttt     1920

ttaaagatag catcagccgt tatcctaaat ggtcaaacgc gtatgatttt aatttctccg     1980

aaacggagaa atataaagac attgctggtt tctatcgcga agtcgaagaa cagggttata     2040

aagttagctt tgaatcggcc agcaagaaag aggttgataa actggtggag gagggtaagc     2100

tgtatatgtt tcagatttat aacaaagact ttagcgacaa aagccacggt actcctaatc     2160

tgcatacgat gtactttaaa ctgctgtttg atgagaataa ccacggccaa atccgtctct     2220

ccggtggagc agaacttttt atgcggcgtg cgagcctaaa aaaggaagaa ctggtggtgc     2280

atcccgccaa cagcccgatt gctaacaaaa atccagataa tcctaagaag accaccacac     2340

tgtcgtacga tgtctataag gataaacgtt tctcggaaga ccagtatgaa ttgcatatac     2400

cgatagcaat taataaatgc ccaaaaaaca ttttcaaaat caacactgaa gttcgtgtgc     2460

tgctgaaaca tgatgataat ccgtatgtga tcggaattga ccgtggggag agaaatctgc     2520

tgtatattgt agtcgttgat ggcaagggca acatcgttga gcagtatagc ctgaatgaaa     2580

taattaataa ttttaacggt atacgtatta aaaccgacta tcatagcctg ctggataaaa     2640

aggagaaaga gcgttttgag gcacgccaaa attggacgag catcgaaaac atcaaggaac     2700

tgaaggcagg atatatcagc caagtagtcc ataaaatctg tgaactggtg gagaagtacg     2760

acgctgtcat tgccctggaa gacctcaata gcggctttaa aaacagccgg gtgaaggtgg     2820

agaaacaggt ataccaaaag tttgaaaaga tgctcattga taagctgaac tatatggttg     2880

ataaaaagag caacccgtgc gccactggcg gtgcactgaa agggtaccaa attaccaata     2940

aatttgaaag ctttaaaagc atgagcacgc agaatgggtt tattttttat ataccagcat     3000

ggctgacgag caagattgac cccagcactg gttttgtcaa tctgctgaaa accaaataca     3060

caagcattgc ggatagcaaa aaatttattt cgagcttcga ccgtattatg tatgttccgg     3120

aggaagatct gtttgaattt gccctggatt ataaaaactt cagccgcacc gatgcagatt     3180

atatcaaaaa atggaagctg tacagttatg gtaatcgtat acgtatcttc cgtaatccga     3240

agaaaaacaa tgtgttcgat tgggaagagg tctgtctgac cagcgcgtat aaagaactgt     3300

tcaacaagta cggaataaat tatcagcaag gtgacattcg cgcactgctg tgtgaacagt     3360

cagataaagc attttatagc agctttatgg cgctgatgag cctgatgctc cagatgcgca     3420

acagcataac cggtcgcaca gatgttgact ttctgatcag ccctgtgaag aatagcgacg     3480

gcatcttcta cgattccagg aactatgaag cacaggaaaa cgctattctg cctaaaaatg     3540

ccgatgccaa cggcgcctat aatattgcac ggaaggttct gtgggcgatt ggacagttca     3600

agaaagcgga agatgagaag ctggataagg taaaaattgc tattagcaat aaggaatggc     3660

tggagtacgc acagacatcg gttaaacacg gtagtaaaag gccggcggcc acgaaaaagg     3720

ccggccaggc aaaaaagaaa aagggagcgg ccgcactcga gcaccaccac caccaccact     3780

gagcggccgc                                                            3790


<210>  58
<211>  8986
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  58
tggcgaatgg gacgcgccct gtagcggcgc attaagcgcg gcgggtgtgg tggttacgcg       60

cagcgtgacc gctacacttg ccagcgccct agcgcccgct cctttcgctt tcttcccttc      120

ctttctcgcc acgttcgccg gctttccccg tcaagctcta aatcgggggc tccctttagg      180

gttccgattt agtgctttac ggcacctcga ccccaaaaaa cttgattagg gtgatggttc      240

acgtagtggg ccatcgccct gatagacggt ttttcgccct ttgacgttgg agtccacgtt      300

ctttaatagt ggactcttgt tccaaactgg aacaacactc aaccctatct cggtctattc      360

ttttgattta taagggattt tgccgatttc ggcctattgg ttaaaaaatg agctgattta      420

acaaaaattt aacgcgaatt ttaacaaaat attaacgttt acaatttcag gtggcacttt      480

tcggggaaat gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta      540

tccgctcatg aattaattct tagaaaaact catcgagcat caaatgaaac tgcaatttat      600

tcatatcagg attatcaata ccatattttt gaaaaagccg tttctgtaat gaaggagaaa      660

actcaccgag gcagttccat aggatggcaa gatcctggta tcggtctgcg attccgactc      720

gtccaacatc aatacaacct attaatttcc cctcgtcaaa aataaggtta tcaagtgaga      780

aatcaccatg agtgacgact gaatccggtg agaatggcaa aagtttatgc atttctttcc      840

agacttgttc aacaggccag ccattacgct cgtcatcaaa atcactcgca tcaaccaaac      900

cgttattcat tcgtgattgc gcctgagcga gacgaaatac gcgatcgctg ttaaaaggac      960

aattacaaac aggaatcgaa tgcaaccggc gcaggaacac tgccagcgca tcaacaatat     1020

tttcacctga atcaggatat tcttctaata cctggaatgc tgttttcccg gggatcgcag     1080

tggtgagtaa ccatgcatca tcaggagtac ggataaaatg cttgatggtc ggaagaggca     1140

taaattccgt cagccagttt agtctgacca tctcatctgt aacatcattg gcaacgctac     1200

ctttgccatg tttcagaaac aactctggcg catcgggctt cccatacaat cgatagattg     1260

tcgcacctga ttgcccgaca ttatcgcgag cccatttata cccatataaa tcagcatcca     1320

tgttggaatt taatcgcggc ctagagcaag acgtttcccg ttgaatatgg ctcataacac     1380

cccttgtatt actgtttatg taagcagaca gttttattgt tcatgaccaa aatcccttaa     1440

cgtgagtttt cgttccactg agcgtcagac cccgtagaaa agatcaaagg atcttcttga     1500

gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg     1560

gtggtttgtt tgccggatca agagctacca actctttttc cgaaggtaac tggcttcagc     1620

agagcgcaga taccaaatac tgtccttcta gtgtagccgt agttaggcca ccacttcaag     1680

aactctgtag caccgcctac atacctcgct ctgctaatcc tgttaccagt ggctgctgcc     1740

agtggcgata agtcgtgtct taccgggttg gactcaagac gatagttacc ggataaggcg     1800

cagcggtcgg gctgaacggg gggttcgtgc acacagccca gcttggagcg aacgacctac     1860

accgaactga gatacctaca gcgtgagcta tgagaaagcg ccacgcttcc cgaagggaga     1920

aaggcggaca ggtatccggt aagcggcagg gtcggaacag gagagcgcac gagggagctt     1980

ccagggggaa acgcctggta tctttatagt cctgtcgggt ttcgccacct ctgacttgag     2040

cgtcgatttt tgtgatgctc gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg     2100

gcctttttac ggttcctggc cttttgctgg ccttttgctc acatgttctt tcctgcgtta     2160

tcccctgatt ctgtggataa ccgtattacc gcctttgagt gagctgatac cgctcgccgc     2220

agccgaacga ccgagcgcag cgagtcagtg agcgaggaag cggaagagcg cctgatgcgg     2280

tattttctcc ttacgcatct gtgcggtatt tcacaccgca tatatggtgc actctcagta     2340

caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc tacgtgactg     2400

ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac gggcttgtct     2460

gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca tgtgtcagag     2520

gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat cagcgtggtc     2580

gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga gtttctccag     2640

aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt tttcctgttt     2700

ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga taccgatgaa     2760

acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt tactggaacg     2820

ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa tcactcaggg     2880

tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc agcagcatcc     2940

tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt ccagacttta     3000

cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg ttttgcagca     3060

gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag taaggcaacc     3120

ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc gtggggccgc     3180

catgccggcg ataatggcct gcttctcgcc gaaacgtttg gtggcgggac cagtgacgaa     3240

ggcttgagcg agggcgtgca agattccgaa taccgcaagc gacaggccga tcatcgtcgc     3300

gctccagcga aagcggtcct cgccgaaaat gacccagagc gctgccggca cctgtcctac     3360

gagttgcatg ataaagaaga cagtcataag tgcggcgacg atagtcatgc cccgcgccca     3420

ccggaaggag ctgactgggt tgaaggctct caagggcatc ggtcgagatc ccggtgccta     3480

atgagtgagc taacttacat taattgcgtt gcgctcactg cccgctttcc agtcgggaaa     3540

cctgtcgtgc cagctgcatt aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat     3600

tgggcgccag ggtggttttt cttttcacca gtgagacggg caacagctga ttgcccttca     3660

ccgcctggcc ctgagagagt tgcagcaagc ggtccacgct ggtttgcccc agcaggcgaa     3720

aatcctgttt gatggtggtt aacggcggga tataacatga gctgtcttcg gtatcgtcgt     3780

atcccactac cgagatatcc gcaccaacgc gcagcccgga ctcggtaatg gcgcgcattg     3840

cgcccagcgc catctgatcg ttggcaacca gcatcgcagt gggaacgatg ccctcattca     3900

gcatttgcat ggtttgttga aaaccggaca tggcactcca gtcgccttcc cgttccgcta     3960

tcggctgaat ttgattgcga gtgagatatt tatgccagcc agccagacgc agacgcgccg     4020

agacagaact taatgggccc gctaacagcg cgatttgctg gtgacccaat gcgaccagat     4080

gctccacgcc cagtcgcgta ccgtcttcat gggagaaaat aatactgttg atgggtgtct     4140

ggtcagagac atcaagaaat aacgccggaa cattagtgca ggcagcttcc acagcaatgg     4200

catcctggtc atccagcgga tagttaatga tcagcccact gacgcgttgc gcgagaagat     4260

tgtgcaccgc cgctttacag gcttcgacgc cgcttcgttc taccatcgac accaccacgc     4320

tggcacccag ttgatcggcg cgagatttaa tcgccgcgac aatttgcgac ggcgcgtgca     4380

gggccagact ggaggtggca acgccaatca gcaacgactg tttgcccgcc agttgttgtg     4440

ccacgcggtt gggaatgtaa ttcagctccg ccatcgccgc ttccactttt tcccgcgttt     4500

tcgcagaaac gtggctggcc tggttcacca cgcgggaaac ggtctgataa gagacaccgg     4560

catactctgc gacatcgtat aacgttactg gtttcacatt caccaccctg aattgactct     4620

cttccgggcg ctatcatgcc ataccgcgaa aggttttgcg ccattcgatg gtgtccggga     4680

tctcgacgct ctcccttatg cgactcctgc attaggaagc agcccagtag taggttgagg     4740

ccgttgagca ccgccgccgc aaggaatggt gcatgcaagg agatggcgcc caacagtccc     4800

ccggccacgg ggcctgccac catacccacg ccgaaacaag cgctcatgag cccgaagtgg     4860

cgagcccgat cttccccatc ggtgatgtcg gcgatatagg cgccagcaac cgcacctgtg     4920

gcgccggtga tgccggccac gatgcgtccg gcgtagagga tcgagatctc gatcccgcga     4980

aattaatacg actcactata ggggaattgt gagcggataa caattcccct ctagaaataa     5040

ttttgtttaa ctttaagaag gagatatacc atgggcagca aactggaaaa atttacgaat     5100

tgttatagcc tgtccaagac cctgcgtttc aaagccatcc ccgttggcaa aacccaggag     5160

aatattgata ataaacgtct gctggttgag gatgaaaaaa gagcagaaga ctataaggga     5220

gtcaaaaaac tgctggatcg gtactacctg agctttataa atgacgtgct gcatagcatt     5280

aaactgaaaa atctgaataa ctatattagt ctgttccgca agaaaacccg aacagagaaa     5340

gaaaataaag agctggaaaa cctggagatc aatctgcgta aagagatcgc aaaagctttt     5400

aaaggaaatg aaggttataa aagcctgttc aaaaaagaca ttattgaaac catcctgccg     5460

gaatttctgg atgataaaga cgagatagcg ctcgtgaaca gcttcaacgg gttcacgacc     5520

gccttcacgg gctttttcga taacagggaa aatatgtttt cagaggaagc caaaagcacc     5580

tcgatagcgt tccgttgcat taatgaaaat ttgacaagat atatcagcaa catggatatt     5640

ttcgagaaag ttgatgcgat ctttgacaaa catgaagtgc aggagattaa ggaaaaaatt     5700

ctgaacagcg attatgatgt tgaggatttt ttcgaggggg aattttttaa ctttgtactg     5760

acacaggaag gtatagatgt gtataatgct attatcggcg ggttcgttac cgaatccggc     5820

gagaaaatta agggtctgaa tgagtacatc aatctgtata accaaaagac caaacagaaa     5880

ctgccaaaat tcaaaccgct gtacaagcaa gtcctgagcg atcgggaaag cttgagcttt     5940

tacggtgaag gttataccag cgacgaggag gtactggagg tctttcgcaa taccctgaac     6000

aagaacagcg aaattttcag ctccattaaa aagctggaga aactgtttaa gaattttgac     6060

gagtacagca gcgcaggtat ttttgtgaag aacggacctg ccataagcac cattagcaag     6120

gatatttttg gagagtggaa tgttatccgt gataaatgga acgcggaata tgatgacata     6180

cacctgaaaa agaaggctgt ggtaactgag aaatatgaag acgatcgccg caaaagcttt     6240

aaaaaaatcg gcagctttag cctggagcag ctgcaggaat atgcggacgc cgacctgagc     6300

gtggtcgaga aactgaagga aattattatc caaaaagtgg atgagattta caaggtatat     6360

ggtagcagcg aaaaactgtt tgatgcggac ttcgttctgg aaaaaagcct gaaaaaaaat     6420

gatgctgttg ttgcgatcat gaaagacctg ctcgatagcg ttaagagctt tgaaaattac     6480

attaaagcat tctttggcga gggcaaagaa acaaacagag acgaaagctt ttatggcgac     6540

ttcgtcctgg cttatgacat cctgttgaag gtagatcata tatatgatgc aattcgtaat     6600

tacgtaaccc aaaagccgta cagcaaagat aagttcaaac tgtatttcca gaacccgcag     6660

tttatgggtg gctgggacaa agacaaggag acagactatc gcgccactat tctgcgttac     6720

ggcagcaagt actatctcgc catcatggac aaaaaatatg caaagtgtct gcagaaaatc     6780

gataaagacg acgtgaacgg aaattacgaa aagattaatt ataagctgct gccagggccc     6840

aacaagatgt taccgaaagt atttttttcc aaaaaatgga tggcatacta taacccgagc     6900

gaggatatac agaagattta caaaaatggg accttcaaaa agggggatat gttcaatctg     6960

aatgactgcc acaaactgat cgattttttt aaagatagca tcagccgtta tcctaaatgg     7020

tcaaacgcgt atgattttaa tttctccgaa acggagaaat ataaagacat tgctggtttc     7080

tatcgcgaag tcgaagaaca gggttataaa gttagctttg aatcggccag caagaaagag     7140

gttgataaac tggtggagga gggtaagctg tatatgtttc agatttataa caaagacttt     7200

agcgacaaaa gccacggtac tcctaatctg catacgatgt actttaaact gctgtttgat     7260

gagaataacc acggccaaat ccgtctctcc ggtggagcag aactttttat gcggcgtgcg     7320

agcctaaaaa aggaagaact ggtggtgcat cccgccaaca gcccgattgc taacaaaaat     7380

ccagataatc ctaagaagac caccacactg tcgtacgatg tctataagga taaacgtttc     7440

tcggaagacc agtatgaatt gcatataccg atagcaatta ataaatgccc aaaaaacatt     7500

ttcaaaatca acactgaagt tcgtgtgctg ctgaaacatg atgataatcc gtatgtgatc     7560

ggaattgacc gtggggagag aaatctgctg tatattgtag tcgttgatgg caagggcaac     7620

atcgttgagc agtatagcct gaatgaaata attaataatt ttaacggtat acgtattaaa     7680

accgactatc atagcctgct ggataaaaag gagaaagagc gttttgaggc acgccaaaat     7740

tggacgagca tcgaaaacat caaggaactg aaggcaggat atatcagcca agtagtccat     7800

aaaatctgtg aactggtgga gaagtacgac gctgtcattg ccctggaaga cctcaatagc     7860

ggctttaaaa acagccgggt gaaggtggag aaacaggtat accaaaagtt tgaaaagatg     7920

ctcattgata agctgaacta tatggttgat aaaaagagca acccgtgcgc cactggcggt     7980

gcactgaaag ggtaccaaat taccaataaa tttgaaagct ttaaaagcat gagcacgcag     8040

aatgggttta ttttttatat accagcatgg ctgacgagca agattgaccc cagcactggt     8100

tttgtcaatc tgctgaaaac caaatacaca agcattgcgg atagcaaaaa atttatttcg     8160

agcttcgacc gtattatgta tgttccggag gaagatctgt ttgaatttgc cctggattat     8220

aaaaacttca gccgcaccga tgcagattat atcaaaaaat ggaagctgta cagttatggt     8280

aatcgtatac gtatcttccg taatccgaag aaaaacaatg tgttcgattg ggaagaggtc     8340

tgtctgacca gcgcgtataa agaactgttc aacaagtacg gaataaatta tcagcaaggt     8400

gacattcgcg cactgctgtg tgaacagtca gataaagcat tttatagcag ctttatggcg     8460

ctgatgagcc tgatgctcca gatgcgcaac agcataaccg gtcgcacaga tgttgacttt     8520

ctgatcagcc ctgtgaagaa tagcgacggc atcttctacg attccaggaa ctatgaagca     8580

caggaaaacg ctattctgcc taaaaatgcc gatgccaacg gcgcctataa tattgcacgg     8640

aaggttctgt gggcgattgg acagttcaag aaagcggaag atgagaagct ggataaggta     8700

aaaattgcta ttagcaataa ggaatggctg gagtacgcac agacatcggt taaacacggt     8760

agtaaaaggc cggcggccac gaaaaaggcc ggccaggcaa aaaagaaaaa gggagcggcc     8820

gcactcgagc accaccacca ccaccactga gatccggctg ctaacaaagc ccgaaaggaa     8880

gctgagttgg ctgctgccac cgctgagcaa taactagcat aaccccttgg ggcctctaaa     8940

cgggtcttga ggggtttttt gctgaaagga ggaactatat ccggat                    8986


<210>  59
<211>  43
<212>  RNA
<213>  Artificial

<220>
<223>  Synthetic CRISPR RNA

<400>  59
aauuucuacu aaguguagau ggaaucccuu cugcagcacc ugg                         43


<210>  60
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic protospacer

<400>  60
ctttcggaat cccttctgca gcacctgg                                          28


<210>  61
<211>  133
<212>  DNA
<213>  Homo sapiens

<400>  61
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  62
<211>  99
<212>  DNA
<213>  Simian virus 40

<400>  62
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctaggc                              99


<210>  63
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  63

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Ser Glu Thr Pro Gly Thr 
    690                 695                 700                 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Lys Leu Glu Lys Phe Thr Asn 
705                 710                 715                 720 


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
                725                 730                 735     


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
            740                 745                 750         


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
        755                 760                 765             


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
    770                 775                 780                 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
785                 790                 795                 800 


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
                805                 810                 815     


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
            820                 825                 830         


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
        835                 840                 845             


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
    850                 855                 860                 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
865                 870                 875                 880 


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
                885                 890                 895     


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
            900                 905                 910         


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
        915                 920                 925             


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
    930                 935                 940                 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
945                 950                 955                 960 


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
                965                 970                 975     


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
            980                 985                 990         


Ser Asp Arg Glu Ser Leu Ser Phe  Tyr Gly Glu Gly Tyr  Thr Ser Asp 
        995                 1000                 1005             


Glu Glu  Val Leu Glu Val Phe  Arg Asn Thr Leu Asn  Lys Asn Ser 
    1010                 1015                 1020             


Glu Ile  Phe Ser Ser Ile Lys  Lys Leu Glu Lys Leu  Phe Lys Asn 
    1025                 1030                 1035             


Phe Asp  Glu Tyr Ser Ser Ala  Gly Ile Phe Val Lys  Asn Gly Pro 
    1040                 1045                 1050             


Ala Ile  Ser Thr Ile Ser Lys  Asp Ile Phe Gly Glu  Trp Asn Val 
    1055                 1060                 1065             


Ile Arg  Asp Lys Trp Asn Ala  Glu Tyr Asp Asp Ile  His Leu Lys 
    1070                 1075                 1080             


Lys Lys  Ala Val Val Thr Glu  Lys Tyr Glu Asp Asp  Arg Arg Lys 
    1085                 1090                 1095             


Ser Phe  Lys Lys Ile Gly Ser  Phe Ser Leu Glu Gln  Leu Gln Glu 
    1100                 1105                 1110             


Tyr Ala  Asp Ala Asp Leu Ser  Val Val Glu Lys Leu  Lys Glu Ile 
    1115                 1120                 1125             


Ile Ile  Gln Lys Val Asp Glu  Ile Tyr Lys Val Tyr  Gly Ser Ser 
    1130                 1135                 1140             


Glu Lys  Leu Phe Asp Ala Asp  Phe Val Leu Glu Lys  Ser Leu Lys 
    1145                 1150                 1155             


Lys Asn  Asp Ala Val Val Ala  Ile Met Lys Asp Leu  Leu Asp Ser 
    1160                 1165                 1170             


Val Lys  Ser Phe Glu Asn Tyr  Ile Lys Ala Phe Phe  Gly Glu Gly 
    1175                 1180                 1185             


Lys Glu  Thr Asn Arg Asp Glu  Ser Phe Tyr Gly Asp  Phe Val Leu 
    1190                 1195                 1200             


Ala Tyr  Asp Ile Leu Leu Lys  Val Asp His Ile Tyr  Asp Ala Ile 
    1205                 1210                 1215             


Arg Asn  Tyr Val Thr Gln Lys  Pro Tyr Ser Lys Asp  Lys Phe Lys 
    1220                 1225                 1230             


Leu Tyr  Phe Gln Asn Pro Gln  Phe Met Arg Gly Trp  Asp Lys Asp 
    1235                 1240                 1245             


Lys Glu  Thr Asp Tyr Arg Ala  Thr Ile Leu Arg Tyr  Gly Ser Lys 
    1250                 1255                 1260             


Tyr Tyr  Leu Ala Ile Met Asp  Lys Lys Tyr Ala Lys  Cys Leu Gln 
    1265                 1270                 1275             


Lys Ile  Asp Lys Asp Asp Val  Asn Gly Asn Tyr Glu  Lys Ile Asn 
    1280                 1285                 1290             


Tyr Lys  Leu Leu Pro Gly Pro  Asn Lys Met Leu Pro  Arg Val Phe 
    1295                 1300                 1305             


Phe Ser  Lys Lys Trp Met Ala  Tyr Tyr Asn Pro Ser  Glu Asp Ile 
    1310                 1315                 1320             


Gln Lys  Ile Tyr Lys Asn Gly  Thr Phe Lys Lys Gly  Asp Met Phe 
    1325                 1330                 1335             


Asn Leu  Asn Asp Cys His Lys  Leu Ile Asp Phe Phe  Lys Asp Ser 
    1340                 1345                 1350             


Ile Ser  Arg Tyr Pro Lys Trp  Ser Asn Ala Tyr Asp  Phe Asn Phe 
    1355                 1360                 1365             


Ser Glu  Thr Glu Lys Tyr Lys  Asp Ile Ala Gly Phe  Tyr Arg Glu 
    1370                 1375                 1380             


Val Glu  Glu Gln Gly Tyr Lys  Val Ser Phe Glu Ser  Ala Ser Lys 
    1385                 1390                 1395             


Lys Glu  Val Asp Lys Leu Val  Glu Glu Gly Lys Leu  Tyr Met Phe 
    1400                 1405                 1410             


Gln Ile  Tyr Asn Lys Asp Phe  Ser Asp Lys Ser His  Gly Thr Pro 
    1415                 1420                 1425             


Asn Leu  His Thr Met Tyr Phe  Lys Leu Leu Phe Asp  Glu Asn Asn 
    1430                 1435                 1440             


His Gly  Gln Ile Arg Leu Ser  Gly Gly Ala Glu Leu  Phe Met Arg 
    1445                 1450                 1455             


Arg Ala  Ser Leu Lys Lys Glu  Glu Leu Val Val His  Pro Ala Asn 
    1460                 1465                 1470             


Ser Pro  Ile Ala Asn Lys Asn  Pro Asp Asn Pro Lys  Lys Thr Thr 
    1475                 1480                 1485             


Thr Leu  Ser Tyr Asp Val Tyr  Lys Asp Lys Arg Phe  Ser Glu Asp 
    1490                 1495                 1500             


Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile Asn Lys  Cys Pro Lys 
    1505                 1510                 1515             


Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg Val Leu  Leu Lys His 
    1520                 1525                 1530             


Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Asp Arg Gly  Glu Arg Asn 
    1535                 1540                 1545             


Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys Gly Asn  Ile Val Glu 
    1550                 1555                 1560             


Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn Phe Asn  Gly Ile Arg 
    1565                 1570                 1575             


Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp Lys Lys  Glu Lys Glu 
    1580                 1585                 1590             


Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser Ile Glu  Asn Ile Lys 
    1595                 1600                 1605             


Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val Val His  Lys Ile Cys 
    1610                 1615                 1620             


Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu 
    1625                 1630                 1635             


Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys Val Glu  Lys Gln Val 
    1640                 1645                 1650             


Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met 
    1655                 1660                 1665             


Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys 
    1670                 1675                 1680             


Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser 
    1685                 1690                 1695             


Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
    1700                 1705                 1710             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1715                 1720                 1725             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1730                 1735                 1740             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1745                 1750                 1755             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1760                 1765                 1770             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1775                 1780                 1785             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1790                 1795                 1800             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1805                 1810                 1815             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1820                 1825                 1830             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1835                 1840                 1845             


Ala Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1850                 1855                 1860             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1865                 1870                 1875             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1880                 1885                 1890             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1895                 1900                 1905             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1910                 1915                 1920             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1925                 1930                 1935             


His Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  64
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  64

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Ser Gly Gly Ser 
    690                 695                 700                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn 
                725                 730                 735     


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
            740                 745                 750         


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
        755                 760                 765             


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
    770                 775                 780                 


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
                805                 810                 815     


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
            820                 825                 830         


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
        835                 840                 845             


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
    850                 855                 860                 


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
865                 870                 875                 880 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
                885                 890                 895     


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
            900                 905                 910         


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
        915                 920                 925             


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
    930                 935                 940                 


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
945                 950                 955                 960 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
                965                 970                 975     


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            980                 985                 990         


Thr Lys Gln Lys Leu Pro Lys Phe  Lys Pro Leu Tyr Lys  Gln Val Leu 
        995                 1000                 1005             


Ser Asp  Arg Glu Ser Leu Ser  Phe Tyr Gly Glu Gly  Tyr Thr Ser 
    1010                 1015                 1020             


Asp Glu  Glu Val Leu Glu Val  Phe Arg Asn Thr Leu  Asn Lys Asn 
    1025                 1030                 1035             


Ser Glu  Ile Phe Ser Ser Ile  Lys Lys Leu Glu Lys  Leu Phe Lys 
    1040                 1045                 1050             


Asn Phe  Asp Glu Tyr Ser Ser  Ala Gly Ile Phe Val  Lys Asn Gly 
    1055                 1060                 1065             


Pro Ala  Ile Ser Thr Ile Ser  Lys Asp Ile Phe Gly  Glu Trp Asn 
    1070                 1075                 1080             


Val Ile  Arg Asp Lys Trp Asn  Ala Glu Tyr Asp Asp  Ile His Leu 
    1085                 1090                 1095             


Lys Lys  Lys Ala Val Val Thr  Glu Lys Tyr Glu Asp  Asp Arg Arg 
    1100                 1105                 1110             


Lys Ser  Phe Lys Lys Ile Gly  Ser Phe Ser Leu Glu  Gln Leu Gln 
    1115                 1120                 1125             


Glu Tyr  Ala Asp Ala Asp Leu  Ser Val Val Glu Lys  Leu Lys Glu 
    1130                 1135                 1140             


Ile Ile  Ile Gln Lys Val Asp  Glu Ile Tyr Lys Val  Tyr Gly Ser 
    1145                 1150                 1155             


Ser Glu  Lys Leu Phe Asp Ala  Asp Phe Val Leu Glu  Lys Ser Leu 
    1160                 1165                 1170             


Lys Lys  Asn Asp Ala Val Val  Ala Ile Met Lys Asp  Leu Leu Asp 
    1175                 1180                 1185             


Ser Val  Lys Ser Phe Glu Asn  Tyr Ile Lys Ala Phe  Phe Gly Glu 
    1190                 1195                 1200             


Gly Lys  Glu Thr Asn Arg Asp  Glu Ser Phe Tyr Gly  Asp Phe Val 
    1205                 1210                 1215             


Leu Ala  Tyr Asp Ile Leu Leu  Lys Val Asp His Ile  Tyr Asp Ala 
    1220                 1225                 1230             


Ile Arg  Asn Tyr Val Thr Gln  Lys Pro Tyr Ser Lys  Asp Lys Phe 
    1235                 1240                 1245             


Lys Leu  Tyr Phe Gln Asn Pro  Gln Phe Met Arg Gly  Trp Asp Lys 
    1250                 1255                 1260             


Asp Lys  Glu Thr Asp Tyr Arg  Ala Thr Ile Leu Arg  Tyr Gly Ser 
    1265                 1270                 1275             


Lys Tyr  Tyr Leu Ala Ile Met  Asp Lys Lys Tyr Ala  Lys Cys Leu 
    1280                 1285                 1290             


Gln Lys  Ile Asp Lys Asp Asp  Val Asn Gly Asn Tyr  Glu Lys Ile 
    1295                 1300                 1305             


Asn Tyr  Lys Leu Leu Pro Gly  Pro Asn Lys Met Leu  Pro Arg Val 
    1310                 1315                 1320             


Phe Phe  Ser Lys Lys Trp Met  Ala Tyr Tyr Asn Pro  Ser Glu Asp 
    1325                 1330                 1335             


Ile Gln  Lys Ile Tyr Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met 
    1340                 1345                 1350             


Phe Asn  Leu Asn Asp Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp 
    1355                 1360                 1365             


Ser Ile  Ser Arg Tyr Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn 
    1370                 1375                 1380             


Phe Ser  Glu Thr Glu Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Glu Val  Glu Glu Gln Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser 
    1400                 1405                 1410             


Lys Lys  Glu Val Asp Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met 
    1415                 1420                 1425             


Phe Gln  Ile Tyr Asn Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr 
    1430                 1435                 1440             


Pro Asn  Leu His Thr Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn 
    1445                 1450                 1455             


Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met 
    1460                 1465                 1470             


Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu Val Val  His Pro Ala 
    1475                 1480                 1485             


Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr 
    1490                 1495                 1500             


Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu 
    1505                 1510                 1515             


Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro 
    1520                 1525                 1530             


Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys 
    1535                 1540                 1545             


His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile Asp Arg  Gly Glu Arg 
    1550                 1555                 1560             


Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly Lys Gly  Asn Ile Val 
    1565                 1570                 1575             


Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile 
    1580                 1585                 1590             


Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys 
    1595                 1600                 1605             


Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile 
    1610                 1615                 1620             


Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln Val Val  His Lys Ile 
    1625                 1630                 1635             


Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val Ile Ala  Leu Glu Asp 
    1640                 1645                 1650             


Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln 
    1655                 1660                 1665             


Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr 
    1670                 1675                 1680             


Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu 
    1685                 1690                 1695             


Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met 
    1700                 1705                 1710             


Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr 
    1715                 1720                 1725             


Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr 
    1730                 1735                 1740             


Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe 
    1745                 1750                 1755             


Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala 
    1760                 1765                 1770             


Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys 
    1775                 1780                 1785             


Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg 
    1790                 1795                 1800             


Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu 
    1805                 1810                 1815             


Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr 
    1820                 1825                 1830             


Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys 
    1835                 1840                 1845             


Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met Ser Leu  Met Leu Gln 
    1850                 1855                 1860             


Met Ala  Asn Ser Ile Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile 
    1865                 1870                 1875             


Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn 
    1880                 1885                 1890             


Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala 
    1895                 1900                 1905             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly 
    1910                 1915                 1920             


Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile 
    1925                 1930                 1935             


Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val 
    1940                 1945                 1950             


Lys His  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  65
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  65

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Arg Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Arg Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Thr 
    1250                 1255                 1260             


Leu Asn  Ile Glu Asp Glu Tyr  Arg Leu His Glu Thr  Ser Lys Glu 
    1265                 1270                 1275             


Pro Asp  Val Ser Leu Gly Ser  Thr Trp Leu Ser Asp  Phe Pro Gln 
    1280                 1285                 1290             


Ala Trp  Ala Glu Thr Gly Gly  Met Gly Leu Ala Val  Arg Gln Ala 
    1295                 1300                 1305             


Pro Leu  Ile Ile Pro Leu Lys  Ala Thr Ser Thr Pro  Val Ser Ile 
    1310                 1315                 1320             


Lys Gln  Tyr Pro Met Ser Gln  Glu Ala Arg Leu Gly  Ile Lys Pro 
    1325                 1330                 1335             


His Ile  Gln Arg Leu Leu Asp  Gln Gly Ile Leu Val  Pro Cys Gln 
    1340                 1345                 1350             


Ser Pro  Trp Asn Thr Pro Leu  Leu Pro Val Lys Lys  Pro Gly Thr 
    1355                 1360                 1365             


Asn Asp  Tyr Arg Pro Val Gln  Asp Leu Arg Glu Val  Asn Lys Arg 
    1370                 1375                 1380             


Val Glu  Asp Ile His Pro Thr  Val Pro Asn Pro Tyr  Asn Leu Leu 
    1385                 1390                 1395             


Ser Gly  Leu Pro Pro Ser His  Gln Trp Tyr Thr Val  Leu Asp Leu 
    1400                 1405                 1410             


Lys Asp  Ala Phe Phe Cys Leu  Arg Leu His Pro Thr  Ser Gln Pro 
    1415                 1420                 1425             


Leu Phe  Ala Phe Glu Trp Arg  Asp Pro Glu Met Gly  Ile Ser Gly 
    1430                 1435                 1440             


Gln Leu  Thr Trp Thr Arg Leu  Pro Gln Gly Phe Lys  Asn Ser Pro 
    1445                 1450                 1455             


Thr Leu  Phe Asn Glu Ala Leu  His Arg Asp Leu Ala  Asp Phe Arg 
    1460                 1465                 1470             


Ile Gln  His Pro Asp Leu Ile  Leu Leu Gln Tyr Val  Asp Asp Leu 
    1475                 1480                 1485             


Leu Leu  Ala Ala Thr Ser Glu  Leu Asp Cys Gln Gln  Gly Thr Arg 
    1490                 1495                 1500             


Ala Leu  Leu Gln Thr Leu Gly  Asn Leu Gly Tyr Arg  Ala Ser Ala 
    1505                 1510                 1515             


Lys Lys  Ala Gln Ile Cys Gln  Lys Gln Val Lys Tyr  Leu Gly Tyr 
    1520                 1525                 1530             


Leu Leu  Lys Glu Gly Gln Arg  Trp Leu Thr Glu Ala  Arg Lys Glu 
    1535                 1540                 1545             


Thr Val  Met Gly Gln Pro Thr  Pro Lys Thr Pro Arg  Gln Leu Arg 
    1550                 1555                 1560             


Glu Phe  Leu Gly Lys Ala Gly  Phe Cys Arg Leu Phe  Ile Pro Gly 
    1565                 1570                 1575             


Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro Leu Thr  Lys Pro Gly 
    1580                 1585                 1590             


Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln Lys Ala  Tyr Gln Glu 
    1595                 1600                 1605             


Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala Leu Gly  Leu Pro Asp 
    1610                 1615                 1620             


Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp Glu Lys  Gln Gly Tyr 
    1625                 1630                 1635             


Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly Pro Trp  Arg Arg Pro 
    1640                 1645                 1650             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro Val Ala  Ala Gly Trp 
    1655                 1660                 1665             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Val  Leu Thr Lys 
    1670                 1675                 1680             


Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro Leu Val  Ile Leu Ala 
    1685                 1690                 1695             


Pro His  Ala Val Glu Ala Leu  Val Lys Gln Pro Pro  Asp Arg Trp 
    1700                 1705                 1710             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Leu  Leu Leu Asp 
    1715                 1720                 1725             


Thr Asp  Arg Val Gln Phe Gly  Pro Val Val Ala Leu  Asn Pro Ala 
    1730                 1735                 1740             


Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu Gln His  Asn Cys Leu 
    1745                 1750                 1755             


Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg Pro Asp  Leu Thr Asp 
    1760                 1765                 1770             


Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp Tyr Thr  Asp Gly Ser 
    1775                 1780                 1785             


Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala Gly Ala  Ala Val Thr 
    1790                 1795                 1800             


Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala Leu Pro  Ala Gly Thr 
    1805                 1810                 1815             


Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu Thr Gln  Ala Leu Lys 
    1820                 1825                 1830             


Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr Thr Asp  Ser Arg Tyr 
    1835                 1840                 1845             


Ala Phe  Ala Thr Ala His Ile  His Gly Glu Ile Tyr  Arg Arg Arg 
    1850                 1855                 1860             


Gly Trp  Leu Thr Ser Glu Gly  Lys Glu Ile Lys Asn  Lys Asp Glu 
    1865                 1870                 1875             


Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu Pro Lys  Arg Leu Ser 
    1880                 1885                 1890             


Ile Ile  His Cys Pro Gly His  Gln Lys Gly His Ser  Ala Glu Ala 
    1895                 1900                 1905             


Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala Arg Lys  Ala Ala Ile 
    1910                 1915                 1920             


Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu Ile Glu  Asn Ser Ser 
    1925                 1930                 1935             


Pro Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  66
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  66

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Arg Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Arg Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1250                 1255                 1260             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1265                 1270                 1275             


Thr Leu  Asn Ile Glu Asp Glu  Tyr Arg Leu His Glu  Thr Ser Lys 
    1280                 1285                 1290             


Glu Pro  Asp Val Ser Leu Gly  Ser Thr Trp Leu Ser  Asp Phe Pro 
    1295                 1300                 1305             


Gln Ala  Trp Ala Glu Thr Gly  Gly Met Gly Leu Ala  Val Arg Gln 
    1310                 1315                 1320             


Ala Pro  Leu Ile Ile Pro Leu  Lys Ala Thr Ser Thr  Pro Val Ser 
    1325                 1330                 1335             


Ile Lys  Gln Tyr Pro Met Ser  Gln Glu Ala Arg Leu  Gly Ile Lys 
    1340                 1345                 1350             


Pro His  Ile Gln Arg Leu Leu  Asp Gln Gly Ile Leu  Val Pro Cys 
    1355                 1360                 1365             


Gln Ser  Pro Trp Asn Thr Pro  Leu Leu Pro Val Lys  Lys Pro Gly 
    1370                 1375                 1380             


Thr Asn  Asp Tyr Arg Pro Val  Gln Asp Leu Arg Glu  Val Asn Lys 
    1385                 1390                 1395             


Arg Val  Glu Asp Ile His Pro  Thr Val Pro Asn Pro  Tyr Asn Leu 
    1400                 1405                 1410             


Leu Ser  Gly Leu Pro Pro Ser  His Gln Trp Tyr Thr  Val Leu Asp 
    1415                 1420                 1425             


Leu Lys  Asp Ala Phe Phe Cys  Leu Arg Leu His Pro  Thr Ser Gln 
    1430                 1435                 1440             


Pro Leu  Phe Ala Phe Glu Trp  Arg Asp Pro Glu Met  Gly Ile Ser 
    1445                 1450                 1455             


Gly Gln  Leu Thr Trp Thr Arg  Leu Pro Gln Gly Phe  Lys Asn Ser 
    1460                 1465                 1470             


Pro Thr  Leu Phe Asn Glu Ala  Leu His Arg Asp Leu  Ala Asp Phe 
    1475                 1480                 1485             


Arg Ile  Gln His Pro Asp Leu  Ile Leu Leu Gln Tyr  Val Asp Asp 
    1490                 1495                 1500             


Leu Leu  Leu Ala Ala Thr Ser  Glu Leu Asp Cys Gln  Gln Gly Thr 
    1505                 1510                 1515             


Arg Ala  Leu Leu Gln Thr Leu  Gly Asn Leu Gly Tyr  Arg Ala Ser 
    1520                 1525                 1530             


Ala Lys  Lys Ala Gln Ile Cys  Gln Lys Gln Val Lys  Tyr Leu Gly 
    1535                 1540                 1545             


Tyr Leu  Leu Lys Glu Gly Gln  Arg Trp Leu Thr Glu  Ala Arg Lys 
    1550                 1555                 1560             


Glu Thr  Val Met Gly Gln Pro  Thr Pro Lys Thr Pro  Arg Gln Leu 
    1565                 1570                 1575             


Arg Glu  Phe Leu Gly Lys Ala  Gly Phe Cys Arg Leu  Phe Ile Pro 
    1580                 1585                 1590             


Gly Phe  Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Pro 
    1595                 1600                 1605             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1610                 1615                 1620             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1625                 1630                 1635             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1640                 1645                 1650             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1655                 1660                 1665             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1670                 1675                 1680             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1685                 1690                 1695             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1700                 1705                 1710             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1715                 1720                 1725             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1730                 1735                 1740             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1745                 1750                 1755             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1760                 1765                 1770             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1775                 1780                 1785             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly 
    1790                 1795                 1800             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1805                 1810                 1815             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1820                 1825                 1830             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1835                 1840                 1845             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1850                 1855                 1860             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1865                 1870                 1875             


Arg Gly  Trp Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1880                 1885                 1890             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1895                 1900                 1905             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1910                 1915                 1920             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1925                 1930                 1935             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ile  Glu Asn Ser 
    1940                 1945                 1950             


Ser Pro  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  67
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  67

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Ser Glu Thr Pro Gly Thr 
    690                 695                 700                 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Lys Leu Glu Lys Phe Thr Asn 
705                 710                 715                 720 


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
                725                 730                 735     


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
            740                 745                 750         


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
        755                 760                 765             


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
    770                 775                 780                 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
785                 790                 795                 800 


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
                805                 810                 815     


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
            820                 825                 830         


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
        835                 840                 845             


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
    850                 855                 860                 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
865                 870                 875                 880 


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
                885                 890                 895     


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
            900                 905                 910         


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
        915                 920                 925             


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
    930                 935                 940                 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
945                 950                 955                 960 


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
                965                 970                 975     


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
            980                 985                 990         


Ser Asp Arg Glu Ser Leu Ser Phe  Tyr Gly Glu Gly Tyr  Thr Ser Asp 
        995                 1000                 1005             


Glu Glu  Val Leu Glu Val Phe  Arg Asn Thr Leu Asn  Lys Asn Ser 
    1010                 1015                 1020             


Glu Ile  Phe Ser Ser Ile Lys  Lys Leu Glu Lys Leu  Phe Lys Asn 
    1025                 1030                 1035             


Phe Asp  Glu Tyr Ser Ser Ala  Gly Ile Phe Val Lys  Asn Gly Pro 
    1040                 1045                 1050             


Ala Ile  Ser Thr Ile Ser Lys  Asp Ile Phe Gly Glu  Trp Asn Val 
    1055                 1060                 1065             


Ile Arg  Asp Lys Trp Asn Ala  Glu Tyr Asp Asp Ile  His Leu Lys 
    1070                 1075                 1080             


Lys Lys  Ala Val Val Thr Glu  Lys Tyr Glu Asp Asp  Arg Arg Lys 
    1085                 1090                 1095             


Ser Phe  Lys Lys Ile Gly Ser  Phe Ser Leu Glu Gln  Leu Gln Glu 
    1100                 1105                 1110             


Tyr Ala  Asp Ala Asp Leu Ser  Val Val Glu Lys Leu  Lys Glu Ile 
    1115                 1120                 1125             


Ile Ile  Gln Lys Val Asp Glu  Ile Tyr Lys Val Tyr  Gly Ser Ser 
    1130                 1135                 1140             


Glu Lys  Leu Phe Asp Ala Asp  Phe Val Leu Glu Lys  Ser Leu Lys 
    1145                 1150                 1155             


Lys Asn  Asp Ala Val Val Ala  Ile Met Lys Asp Leu  Leu Asp Ser 
    1160                 1165                 1170             


Val Lys  Ser Phe Glu Asn Tyr  Ile Lys Ala Phe Phe  Gly Glu Gly 
    1175                 1180                 1185             


Lys Glu  Thr Asn Arg Asp Glu  Ser Phe Tyr Gly Asp  Phe Val Leu 
    1190                 1195                 1200             


Ala Tyr  Asp Ile Leu Leu Lys  Val Asp His Ile Tyr  Asp Ala Ile 
    1205                 1210                 1215             


Arg Asn  Tyr Val Thr Gln Lys  Pro Tyr Ser Lys Asp  Lys Phe Lys 
    1220                 1225                 1230             


Leu Tyr  Phe Gln Asn Pro Gln  Phe Met Arg Gly Trp  Asp Lys Asp 
    1235                 1240                 1245             


Val Glu  Thr Asp Tyr Arg Ala  Thr Ile Leu Arg Tyr  Gly Ser Lys 
    1250                 1255                 1260             


Tyr Tyr  Leu Ala Ile Met Asp  Lys Lys Tyr Ala Lys  Cys Leu Gln 
    1265                 1270                 1275             


Lys Ile  Asp Lys Asp Asp Val  Asn Gly Asn Tyr Glu  Lys Ile Asn 
    1280                 1285                 1290             


Tyr Lys  Leu Leu Pro Gly Pro  Asn Lys Met Leu Pro  Arg Val Phe 
    1295                 1300                 1305             


Phe Ser  Lys Lys Trp Met Ala  Tyr Tyr Asn Pro Ser  Glu Asp Ile 
    1310                 1315                 1320             


Gln Lys  Ile Tyr Lys Asn Gly  Thr Phe Lys Lys Gly  Asp Met Phe 
    1325                 1330                 1335             


Asn Leu  Asn Asp Cys His Lys  Leu Ile Asp Phe Phe  Lys Asp Ser 
    1340                 1345                 1350             


Ile Ser  Arg Tyr Pro Lys Trp  Ser Asn Ala Tyr Asp  Phe Asn Phe 
    1355                 1360                 1365             


Ser Glu  Thr Glu Lys Tyr Lys  Asp Ile Ala Gly Phe  Tyr Arg Glu 
    1370                 1375                 1380             


Val Glu  Glu Gln Gly Tyr Lys  Val Ser Phe Glu Ser  Ala Ser Lys 
    1385                 1390                 1395             


Lys Glu  Val Asp Lys Leu Val  Glu Glu Gly Lys Leu  Tyr Met Phe 
    1400                 1405                 1410             


Gln Ile  Tyr Asn Lys Asp Phe  Ser Asp Lys Ser His  Gly Thr Pro 
    1415                 1420                 1425             


Asn Leu  His Thr Met Tyr Phe  Lys Leu Leu Phe Asp  Glu Asn Asn 
    1430                 1435                 1440             


His Gly  Gln Ile Arg Leu Ser  Gly Gly Ala Glu Leu  Phe Met Arg 
    1445                 1450                 1455             


Arg Ala  Ser Leu Lys Lys Glu  Glu Leu Val Val His  Pro Ala Asn 
    1460                 1465                 1470             


Ser Pro  Ile Ala Asn Lys Asn  Pro Asp Asn Pro Lys  Lys Thr Thr 
    1475                 1480                 1485             


Thr Leu  Ser Tyr Asp Val Tyr  Lys Asp Lys Arg Phe  Ser Glu Asp 
    1490                 1495                 1500             


Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile Asn Lys  Cys Pro Lys 
    1505                 1510                 1515             


Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg Val Leu  Leu Lys His 
    1520                 1525                 1530             


Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Asp Arg Gly  Glu Arg Asn 
    1535                 1540                 1545             


Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys Gly Asn  Ile Val Glu 
    1550                 1555                 1560             


Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn Phe Asn  Gly Ile Arg 
    1565                 1570                 1575             


Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp Lys Lys  Glu Lys Glu 
    1580                 1585                 1590             


Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser Ile Glu  Asn Ile Lys 
    1595                 1600                 1605             


Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val Val His  Lys Ile Cys 
    1610                 1615                 1620             


Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu 
    1625                 1630                 1635             


Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys Val Glu  Lys Gln Val 
    1640                 1645                 1650             


Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met 
    1655                 1660                 1665             


Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys 
    1670                 1675                 1680             


Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser 
    1685                 1690                 1695             


Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
    1700                 1705                 1710             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1715                 1720                 1725             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1730                 1735                 1740             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1745                 1750                 1755             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1760                 1765                 1770             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1775                 1780                 1785             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1790                 1795                 1800             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1805                 1810                 1815             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1820                 1825                 1830             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1835                 1840                 1845             


Ala Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1850                 1855                 1860             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1865                 1870                 1875             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1880                 1885                 1890             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1895                 1900                 1905             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1910                 1915                 1920             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1925                 1930                 1935             


His Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  68
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  68

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Ser Gly Gly Ser 
    690                 695                 700                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn 
                725                 730                 735     


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
            740                 745                 750         


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
        755                 760                 765             


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
    770                 775                 780                 


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
                805                 810                 815     


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
            820                 825                 830         


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
        835                 840                 845             


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
    850                 855                 860                 


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
865                 870                 875                 880 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
                885                 890                 895     


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
            900                 905                 910         


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
        915                 920                 925             


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
    930                 935                 940                 


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
945                 950                 955                 960 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
                965                 970                 975     


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            980                 985                 990         


Thr Lys Gln Lys Leu Pro Lys Phe  Lys Pro Leu Tyr Lys  Gln Val Leu 
        995                 1000                 1005             


Ser Asp  Arg Glu Ser Leu Ser  Phe Tyr Gly Glu Gly  Tyr Thr Ser 
    1010                 1015                 1020             


Asp Glu  Glu Val Leu Glu Val  Phe Arg Asn Thr Leu  Asn Lys Asn 
    1025                 1030                 1035             


Ser Glu  Ile Phe Ser Ser Ile  Lys Lys Leu Glu Lys  Leu Phe Lys 
    1040                 1045                 1050             


Asn Phe  Asp Glu Tyr Ser Ser  Ala Gly Ile Phe Val  Lys Asn Gly 
    1055                 1060                 1065             


Pro Ala  Ile Ser Thr Ile Ser  Lys Asp Ile Phe Gly  Glu Trp Asn 
    1070                 1075                 1080             


Val Ile  Arg Asp Lys Trp Asn  Ala Glu Tyr Asp Asp  Ile His Leu 
    1085                 1090                 1095             


Lys Lys  Lys Ala Val Val Thr  Glu Lys Tyr Glu Asp  Asp Arg Arg 
    1100                 1105                 1110             


Lys Ser  Phe Lys Lys Ile Gly  Ser Phe Ser Leu Glu  Gln Leu Gln 
    1115                 1120                 1125             


Glu Tyr  Ala Asp Ala Asp Leu  Ser Val Val Glu Lys  Leu Lys Glu 
    1130                 1135                 1140             


Ile Ile  Ile Gln Lys Val Asp  Glu Ile Tyr Lys Val  Tyr Gly Ser 
    1145                 1150                 1155             


Ser Glu  Lys Leu Phe Asp Ala  Asp Phe Val Leu Glu  Lys Ser Leu 
    1160                 1165                 1170             


Lys Lys  Asn Asp Ala Val Val  Ala Ile Met Lys Asp  Leu Leu Asp 
    1175                 1180                 1185             


Ser Val  Lys Ser Phe Glu Asn  Tyr Ile Lys Ala Phe  Phe Gly Glu 
    1190                 1195                 1200             


Gly Lys  Glu Thr Asn Arg Asp  Glu Ser Phe Tyr Gly  Asp Phe Val 
    1205                 1210                 1215             


Leu Ala  Tyr Asp Ile Leu Leu  Lys Val Asp His Ile  Tyr Asp Ala 
    1220                 1225                 1230             


Ile Arg  Asn Tyr Val Thr Gln  Lys Pro Tyr Ser Lys  Asp Lys Phe 
    1235                 1240                 1245             


Lys Leu  Tyr Phe Gln Asn Pro  Gln Phe Met Arg Gly  Trp Asp Lys 
    1250                 1255                 1260             


Asp Val  Glu Thr Asp Tyr Arg  Ala Thr Ile Leu Arg  Tyr Gly Ser 
    1265                 1270                 1275             


Lys Tyr  Tyr Leu Ala Ile Met  Asp Lys Lys Tyr Ala  Lys Cys Leu 
    1280                 1285                 1290             


Gln Lys  Ile Asp Lys Asp Asp  Val Asn Gly Asn Tyr  Glu Lys Ile 
    1295                 1300                 1305             


Asn Tyr  Lys Leu Leu Pro Gly  Pro Asn Lys Met Leu  Pro Arg Val 
    1310                 1315                 1320             


Phe Phe  Ser Lys Lys Trp Met  Ala Tyr Tyr Asn Pro  Ser Glu Asp 
    1325                 1330                 1335             


Ile Gln  Lys Ile Tyr Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met 
    1340                 1345                 1350             


Phe Asn  Leu Asn Asp Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp 
    1355                 1360                 1365             


Ser Ile  Ser Arg Tyr Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn 
    1370                 1375                 1380             


Phe Ser  Glu Thr Glu Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Glu Val  Glu Glu Gln Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser 
    1400                 1405                 1410             


Lys Lys  Glu Val Asp Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met 
    1415                 1420                 1425             


Phe Gln  Ile Tyr Asn Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr 
    1430                 1435                 1440             


Pro Asn  Leu His Thr Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn 
    1445                 1450                 1455             


Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met 
    1460                 1465                 1470             


Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu Val Val  His Pro Ala 
    1475                 1480                 1485             


Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr 
    1490                 1495                 1500             


Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu 
    1505                 1510                 1515             


Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro 
    1520                 1525                 1530             


Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys 
    1535                 1540                 1545             


His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile Asp Arg  Gly Glu Arg 
    1550                 1555                 1560             


Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly Lys Gly  Asn Ile Val 
    1565                 1570                 1575             


Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile 
    1580                 1585                 1590             


Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys 
    1595                 1600                 1605             


Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile 
    1610                 1615                 1620             


Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln Val Val  His Lys Ile 
    1625                 1630                 1635             


Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val Ile Ala  Leu Glu Asp 
    1640                 1645                 1650             


Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln 
    1655                 1660                 1665             


Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr 
    1670                 1675                 1680             


Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu 
    1685                 1690                 1695             


Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met 
    1700                 1705                 1710             


Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr 
    1715                 1720                 1725             


Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr 
    1730                 1735                 1740             


Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe 
    1745                 1750                 1755             


Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala 
    1760                 1765                 1770             


Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys 
    1775                 1780                 1785             


Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg 
    1790                 1795                 1800             


Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu 
    1805                 1810                 1815             


Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr 
    1820                 1825                 1830             


Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys 
    1835                 1840                 1845             


Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met Ser Leu  Met Leu Gln 
    1850                 1855                 1860             


Met Ala  Asn Ser Ile Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile 
    1865                 1870                 1875             


Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn 
    1880                 1885                 1890             


Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala 
    1895                 1900                 1905             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly 
    1910                 1915                 1920             


Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile 
    1925                 1930                 1935             


Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val 
    1940                 1945                 1950             


Lys His  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  69
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  69

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Arg Gly Trp Asp Lys Asp Val Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Arg Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Thr 
    1250                 1255                 1260             


Leu Asn  Ile Glu Asp Glu Tyr  Arg Leu His Glu Thr  Ser Lys Glu 
    1265                 1270                 1275             


Pro Asp  Val Ser Leu Gly Ser  Thr Trp Leu Ser Asp  Phe Pro Gln 
    1280                 1285                 1290             


Ala Trp  Ala Glu Thr Gly Gly  Met Gly Leu Ala Val  Arg Gln Ala 
    1295                 1300                 1305             


Pro Leu  Ile Ile Pro Leu Lys  Ala Thr Ser Thr Pro  Val Ser Ile 
    1310                 1315                 1320             


Lys Gln  Tyr Pro Met Ser Gln  Glu Ala Arg Leu Gly  Ile Lys Pro 
    1325                 1330                 1335             


His Ile  Gln Arg Leu Leu Asp  Gln Gly Ile Leu Val  Pro Cys Gln 
    1340                 1345                 1350             


Ser Pro  Trp Asn Thr Pro Leu  Leu Pro Val Lys Lys  Pro Gly Thr 
    1355                 1360                 1365             


Asn Asp  Tyr Arg Pro Val Gln  Asp Leu Arg Glu Val  Asn Lys Arg 
    1370                 1375                 1380             


Val Glu  Asp Ile His Pro Thr  Val Pro Asn Pro Tyr  Asn Leu Leu 
    1385                 1390                 1395             


Ser Gly  Leu Pro Pro Ser His  Gln Trp Tyr Thr Val  Leu Asp Leu 
    1400                 1405                 1410             


Lys Asp  Ala Phe Phe Cys Leu  Arg Leu His Pro Thr  Ser Gln Pro 
    1415                 1420                 1425             


Leu Phe  Ala Phe Glu Trp Arg  Asp Pro Glu Met Gly  Ile Ser Gly 
    1430                 1435                 1440             


Gln Leu  Thr Trp Thr Arg Leu  Pro Gln Gly Phe Lys  Asn Ser Pro 
    1445                 1450                 1455             


Thr Leu  Phe Asn Glu Ala Leu  His Arg Asp Leu Ala  Asp Phe Arg 
    1460                 1465                 1470             


Ile Gln  His Pro Asp Leu Ile  Leu Leu Gln Tyr Val  Asp Asp Leu 
    1475                 1480                 1485             


Leu Leu  Ala Ala Thr Ser Glu  Leu Asp Cys Gln Gln  Gly Thr Arg 
    1490                 1495                 1500             


Ala Leu  Leu Gln Thr Leu Gly  Asn Leu Gly Tyr Arg  Ala Ser Ala 
    1505                 1510                 1515             


Lys Lys  Ala Gln Ile Cys Gln  Lys Gln Val Lys Tyr  Leu Gly Tyr 
    1520                 1525                 1530             


Leu Leu  Lys Glu Gly Gln Arg  Trp Leu Thr Glu Ala  Arg Lys Glu 
    1535                 1540                 1545             


Thr Val  Met Gly Gln Pro Thr  Pro Lys Thr Pro Arg  Gln Leu Arg 
    1550                 1555                 1560             


Glu Phe  Leu Gly Lys Ala Gly  Phe Cys Arg Leu Phe  Ile Pro Gly 
    1565                 1570                 1575             


Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro Leu Thr  Lys Pro Gly 
    1580                 1585                 1590             


Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln Lys Ala  Tyr Gln Glu 
    1595                 1600                 1605             


Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala Leu Gly  Leu Pro Asp 
    1610                 1615                 1620             


Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp Glu Lys  Gln Gly Tyr 
    1625                 1630                 1635             


Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly Pro Trp  Arg Arg Pro 
    1640                 1645                 1650             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro Val Ala  Ala Gly Trp 
    1655                 1660                 1665             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Val  Leu Thr Lys 
    1670                 1675                 1680             


Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro Leu Val  Ile Leu Ala 
    1685                 1690                 1695             


Pro His  Ala Val Glu Ala Leu  Val Lys Gln Pro Pro  Asp Arg Trp 
    1700                 1705                 1710             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Leu  Leu Leu Asp 
    1715                 1720                 1725             


Thr Asp  Arg Val Gln Phe Gly  Pro Val Val Ala Leu  Asn Pro Ala 
    1730                 1735                 1740             


Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu Gln His  Asn Cys Leu 
    1745                 1750                 1755             


Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg Pro Asp  Leu Thr Asp 
    1760                 1765                 1770             


Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp Tyr Thr  Asp Gly Ser 
    1775                 1780                 1785             


Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala Gly Ala  Ala Val Thr 
    1790                 1795                 1800             


Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala Leu Pro  Ala Gly Thr 
    1805                 1810                 1815             


Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu Thr Gln  Ala Leu Lys 
    1820                 1825                 1830             


Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr Thr Asp  Ser Arg Tyr 
    1835                 1840                 1845             


Ala Phe  Ala Thr Ala His Ile  His Gly Glu Ile Tyr  Arg Arg Arg 
    1850                 1855                 1860             


Gly Trp  Leu Thr Ser Glu Gly  Lys Glu Ile Lys Asn  Lys Asp Glu 
    1865                 1870                 1875             


Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu Pro Lys  Arg Leu Ser 
    1880                 1885                 1890             


Ile Ile  His Cys Pro Gly His  Gln Lys Gly His Ser  Ala Glu Ala 
    1895                 1900                 1905             


Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala Arg Lys  Ala Ala Ile 
    1910                 1915                 1920             


Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu Ile Glu  Asn Ser Ser 
    1925                 1930                 1935             


Pro Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  70
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  70

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Arg Gly Trp Asp Lys Asp Val Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Arg Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1250                 1255                 1260             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1265                 1270                 1275             


Thr Leu  Asn Ile Glu Asp Glu  Tyr Arg Leu His Glu  Thr Ser Lys 
    1280                 1285                 1290             


Glu Pro  Asp Val Ser Leu Gly  Ser Thr Trp Leu Ser  Asp Phe Pro 
    1295                 1300                 1305             


Gln Ala  Trp Ala Glu Thr Gly  Gly Met Gly Leu Ala  Val Arg Gln 
    1310                 1315                 1320             


Ala Pro  Leu Ile Ile Pro Leu  Lys Ala Thr Ser Thr  Pro Val Ser 
    1325                 1330                 1335             


Ile Lys  Gln Tyr Pro Met Ser  Gln Glu Ala Arg Leu  Gly Ile Lys 
    1340                 1345                 1350             


Pro His  Ile Gln Arg Leu Leu  Asp Gln Gly Ile Leu  Val Pro Cys 
    1355                 1360                 1365             


Gln Ser  Pro Trp Asn Thr Pro  Leu Leu Pro Val Lys  Lys Pro Gly 
    1370                 1375                 1380             


Thr Asn  Asp Tyr Arg Pro Val  Gln Asp Leu Arg Glu  Val Asn Lys 
    1385                 1390                 1395             


Arg Val  Glu Asp Ile His Pro  Thr Val Pro Asn Pro  Tyr Asn Leu 
    1400                 1405                 1410             


Leu Ser  Gly Leu Pro Pro Ser  His Gln Trp Tyr Thr  Val Leu Asp 
    1415                 1420                 1425             


Leu Lys  Asp Ala Phe Phe Cys  Leu Arg Leu His Pro  Thr Ser Gln 
    1430                 1435                 1440             


Pro Leu  Phe Ala Phe Glu Trp  Arg Asp Pro Glu Met  Gly Ile Ser 
    1445                 1450                 1455             


Gly Gln  Leu Thr Trp Thr Arg  Leu Pro Gln Gly Phe  Lys Asn Ser 
    1460                 1465                 1470             


Pro Thr  Leu Phe Asn Glu Ala  Leu His Arg Asp Leu  Ala Asp Phe 
    1475                 1480                 1485             


Arg Ile  Gln His Pro Asp Leu  Ile Leu Leu Gln Tyr  Val Asp Asp 
    1490                 1495                 1500             


Leu Leu  Leu Ala Ala Thr Ser  Glu Leu Asp Cys Gln  Gln Gly Thr 
    1505                 1510                 1515             


Arg Ala  Leu Leu Gln Thr Leu  Gly Asn Leu Gly Tyr  Arg Ala Ser 
    1520                 1525                 1530             


Ala Lys  Lys Ala Gln Ile Cys  Gln Lys Gln Val Lys  Tyr Leu Gly 
    1535                 1540                 1545             


Tyr Leu  Leu Lys Glu Gly Gln  Arg Trp Leu Thr Glu  Ala Arg Lys 
    1550                 1555                 1560             


Glu Thr  Val Met Gly Gln Pro  Thr Pro Lys Thr Pro  Arg Gln Leu 
    1565                 1570                 1575             


Arg Glu  Phe Leu Gly Lys Ala  Gly Phe Cys Arg Leu  Phe Ile Pro 
    1580                 1585                 1590             


Gly Phe  Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Pro 
    1595                 1600                 1605             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1610                 1615                 1620             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1625                 1630                 1635             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1640                 1645                 1650             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1655                 1660                 1665             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1670                 1675                 1680             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1685                 1690                 1695             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1700                 1705                 1710             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1715                 1720                 1725             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1730                 1735                 1740             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1745                 1750                 1755             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1760                 1765                 1770             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1775                 1780                 1785             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly 
    1790                 1795                 1800             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1805                 1810                 1815             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1820                 1825                 1830             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1835                 1840                 1845             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1850                 1855                 1860             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1865                 1870                 1875             


Arg Gly  Trp Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1880                 1885                 1890             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1895                 1900                 1905             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1910                 1915                 1920             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1925                 1930                 1935             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ile  Glu Asn Ser 
    1940                 1945                 1950             


Ser Pro  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  71
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  71

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Ser Glu Thr Pro Gly Thr 
    690                 695                 700                 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Lys Leu Glu Lys Phe Thr Asn 
705                 710                 715                 720 


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
                725                 730                 735     


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
            740                 745                 750         


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
        755                 760                 765             


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
    770                 775                 780                 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
785                 790                 795                 800 


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
                805                 810                 815     


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
            820                 825                 830         


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
        835                 840                 845             


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
    850                 855                 860                 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
865                 870                 875                 880 


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
                885                 890                 895     


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
            900                 905                 910         


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
        915                 920                 925             


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
    930                 935                 940                 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
945                 950                 955                 960 


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
                965                 970                 975     


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
            980                 985                 990         


Ser Asp Arg Glu Ser Leu Ser Phe  Tyr Gly Glu Gly Tyr  Thr Ser Asp 
        995                 1000                 1005             


Glu Glu  Val Leu Glu Val Phe  Arg Asn Thr Leu Asn  Lys Asn Ser 
    1010                 1015                 1020             


Glu Ile  Phe Ser Ser Ile Lys  Lys Leu Glu Lys Leu  Phe Lys Asn 
    1025                 1030                 1035             


Phe Asp  Glu Tyr Ser Ser Ala  Gly Ile Phe Val Lys  Asn Gly Pro 
    1040                 1045                 1050             


Ala Ile  Ser Thr Ile Ser Lys  Asp Ile Phe Gly Glu  Trp Asn Val 
    1055                 1060                 1065             


Ile Arg  Asp Lys Trp Asn Ala  Glu Tyr Asp Asp Ile  His Leu Lys 
    1070                 1075                 1080             


Lys Lys  Ala Val Val Thr Glu  Lys Tyr Glu Asp Asp  Arg Arg Lys 
    1085                 1090                 1095             


Ser Phe  Lys Lys Ile Gly Ser  Phe Ser Leu Glu Gln  Leu Gln Glu 
    1100                 1105                 1110             


Tyr Ala  Asp Ala Asp Leu Ser  Val Val Glu Lys Leu  Lys Glu Ile 
    1115                 1120                 1125             


Ile Ile  Gln Lys Val Asp Glu  Ile Tyr Lys Val Tyr  Gly Ser Ser 
    1130                 1135                 1140             


Glu Lys  Leu Phe Asp Ala Asp  Phe Val Leu Glu Lys  Ser Leu Lys 
    1145                 1150                 1155             


Lys Asn  Asp Ala Val Val Ala  Ile Met Lys Asp Leu  Leu Asp Ser 
    1160                 1165                 1170             


Val Lys  Ser Phe Glu Asn Tyr  Ile Lys Ala Phe Phe  Gly Glu Gly 
    1175                 1180                 1185             


Lys Glu  Thr Asn Arg Asp Glu  Ser Phe Tyr Gly Asp  Phe Val Leu 
    1190                 1195                 1200             


Ala Tyr  Asp Ile Leu Leu Lys  Val Asp His Ile Tyr  Asp Ala Ile 
    1205                 1210                 1215             


Arg Asn  Tyr Val Thr Gln Lys  Pro Tyr Ser Lys Asp  Lys Phe Lys 
    1220                 1225                 1230             


Leu Tyr  Phe Gln Asn Pro Gln  Phe Met Gly Gly Trp  Asp Lys Asp 
    1235                 1240                 1245             


Lys Glu  Thr Asp Tyr Arg Ala  Thr Ile Leu Arg Tyr  Gly Ser Lys 
    1250                 1255                 1260             


Tyr Tyr  Leu Ala Ile Met Asp  Lys Lys Tyr Ala Lys  Cys Leu Gln 
    1265                 1270                 1275             


Lys Ile  Asp Lys Asp Asp Val  Asn Gly Asn Tyr Glu  Lys Ile Asn 
    1280                 1285                 1290             


Tyr Lys  Leu Leu Pro Gly Pro  Asn Lys Met Leu Pro  Lys Val Phe 
    1295                 1300                 1305             


Phe Ser  Lys Lys Trp Met Ala  Tyr Tyr Asn Pro Ser  Glu Asp Ile 
    1310                 1315                 1320             


Gln Lys  Ile Tyr Lys Asn Gly  Thr Phe Lys Lys Gly  Asp Met Phe 
    1325                 1330                 1335             


Asn Leu  Asn Asp Cys His Lys  Leu Ile Asp Phe Phe  Lys Asp Ser 
    1340                 1345                 1350             


Ile Ser  Arg Tyr Pro Lys Trp  Ser Asn Ala Tyr Asp  Phe Asn Phe 
    1355                 1360                 1365             


Ser Glu  Thr Glu Lys Tyr Lys  Asp Ile Ala Gly Phe  Tyr Arg Glu 
    1370                 1375                 1380             


Val Glu  Glu Gln Gly Tyr Lys  Val Ser Phe Glu Ser  Ala Ser Lys 
    1385                 1390                 1395             


Lys Glu  Val Asp Lys Leu Val  Glu Glu Gly Lys Leu  Tyr Met Phe 
    1400                 1405                 1410             


Gln Ile  Tyr Asn Lys Asp Phe  Ser Asp Lys Ser His  Gly Thr Pro 
    1415                 1420                 1425             


Asn Leu  His Thr Met Tyr Phe  Lys Leu Leu Phe Asp  Glu Asn Asn 
    1430                 1435                 1440             


His Gly  Gln Ile Arg Leu Ser  Gly Gly Ala Glu Leu  Phe Met Arg 
    1445                 1450                 1455             


Arg Ala  Ser Leu Lys Lys Glu  Glu Leu Val Val His  Pro Ala Asn 
    1460                 1465                 1470             


Ser Pro  Ile Ala Asn Lys Asn  Pro Asp Asn Pro Lys  Lys Thr Thr 
    1475                 1480                 1485             


Thr Leu  Ser Tyr Asp Val Tyr  Lys Asp Lys Arg Phe  Ser Glu Asp 
    1490                 1495                 1500             


Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile Asn Lys  Cys Pro Lys 
    1505                 1510                 1515             


Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg Val Leu  Leu Lys His 
    1520                 1525                 1530             


Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Asp Arg Gly  Glu Arg Asn 
    1535                 1540                 1545             


Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys Gly Asn  Ile Val Glu 
    1550                 1555                 1560             


Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn Phe Asn  Gly Ile Arg 
    1565                 1570                 1575             


Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp Lys Lys  Glu Lys Glu 
    1580                 1585                 1590             


Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser Ile Glu  Asn Ile Lys 
    1595                 1600                 1605             


Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val Val His  Lys Ile Cys 
    1610                 1615                 1620             


Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu 
    1625                 1630                 1635             


Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys Val Glu  Lys Gln Val 
    1640                 1645                 1650             


Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met 
    1655                 1660                 1665             


Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys 
    1670                 1675                 1680             


Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser 
    1685                 1690                 1695             


Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
    1700                 1705                 1710             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1715                 1720                 1725             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1730                 1735                 1740             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1745                 1750                 1755             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1760                 1765                 1770             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1775                 1780                 1785             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1790                 1795                 1800             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1805                 1810                 1815             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1820                 1825                 1830             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1835                 1840                 1845             


Ala Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1850                 1855                 1860             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1865                 1870                 1875             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1880                 1885                 1890             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1895                 1900                 1905             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1910                 1915                 1920             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1925                 1930                 1935             


His Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  72
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  72

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Ser Gly Gly Ser 
    690                 695                 700                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn 
                725                 730                 735     


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
            740                 745                 750         


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
        755                 760                 765             


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
    770                 775                 780                 


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
                805                 810                 815     


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
            820                 825                 830         


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
        835                 840                 845             


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
    850                 855                 860                 


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
865                 870                 875                 880 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
                885                 890                 895     


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
            900                 905                 910         


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
        915                 920                 925             


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
    930                 935                 940                 


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
945                 950                 955                 960 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
                965                 970                 975     


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            980                 985                 990         


Thr Lys Gln Lys Leu Pro Lys Phe  Lys Pro Leu Tyr Lys  Gln Val Leu 
        995                 1000                 1005             


Ser Asp  Arg Glu Ser Leu Ser  Phe Tyr Gly Glu Gly  Tyr Thr Ser 
    1010                 1015                 1020             


Asp Glu  Glu Val Leu Glu Val  Phe Arg Asn Thr Leu  Asn Lys Asn 
    1025                 1030                 1035             


Ser Glu  Ile Phe Ser Ser Ile  Lys Lys Leu Glu Lys  Leu Phe Lys 
    1040                 1045                 1050             


Asn Phe  Asp Glu Tyr Ser Ser  Ala Gly Ile Phe Val  Lys Asn Gly 
    1055                 1060                 1065             


Pro Ala  Ile Ser Thr Ile Ser  Lys Asp Ile Phe Gly  Glu Trp Asn 
    1070                 1075                 1080             


Val Ile  Arg Asp Lys Trp Asn  Ala Glu Tyr Asp Asp  Ile His Leu 
    1085                 1090                 1095             


Lys Lys  Lys Ala Val Val Thr  Glu Lys Tyr Glu Asp  Asp Arg Arg 
    1100                 1105                 1110             


Lys Ser  Phe Lys Lys Ile Gly  Ser Phe Ser Leu Glu  Gln Leu Gln 
    1115                 1120                 1125             


Glu Tyr  Ala Asp Ala Asp Leu  Ser Val Val Glu Lys  Leu Lys Glu 
    1130                 1135                 1140             


Ile Ile  Ile Gln Lys Val Asp  Glu Ile Tyr Lys Val  Tyr Gly Ser 
    1145                 1150                 1155             


Ser Glu  Lys Leu Phe Asp Ala  Asp Phe Val Leu Glu  Lys Ser Leu 
    1160                 1165                 1170             


Lys Lys  Asn Asp Ala Val Val  Ala Ile Met Lys Asp  Leu Leu Asp 
    1175                 1180                 1185             


Ser Val  Lys Ser Phe Glu Asn  Tyr Ile Lys Ala Phe  Phe Gly Glu 
    1190                 1195                 1200             


Gly Lys  Glu Thr Asn Arg Asp  Glu Ser Phe Tyr Gly  Asp Phe Val 
    1205                 1210                 1215             


Leu Ala  Tyr Asp Ile Leu Leu  Lys Val Asp His Ile  Tyr Asp Ala 
    1220                 1225                 1230             


Ile Arg  Asn Tyr Val Thr Gln  Lys Pro Tyr Ser Lys  Asp Lys Phe 
    1235                 1240                 1245             


Lys Leu  Tyr Phe Gln Asn Pro  Gln Phe Met Gly Gly  Trp Asp Lys 
    1250                 1255                 1260             


Asp Lys  Glu Thr Asp Tyr Arg  Ala Thr Ile Leu Arg  Tyr Gly Ser 
    1265                 1270                 1275             


Lys Tyr  Tyr Leu Ala Ile Met  Asp Lys Lys Tyr Ala  Lys Cys Leu 
    1280                 1285                 1290             


Gln Lys  Ile Asp Lys Asp Asp  Val Asn Gly Asn Tyr  Glu Lys Ile 
    1295                 1300                 1305             


Asn Tyr  Lys Leu Leu Pro Gly  Pro Asn Lys Met Leu  Pro Lys Val 
    1310                 1315                 1320             


Phe Phe  Ser Lys Lys Trp Met  Ala Tyr Tyr Asn Pro  Ser Glu Asp 
    1325                 1330                 1335             


Ile Gln  Lys Ile Tyr Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met 
    1340                 1345                 1350             


Phe Asn  Leu Asn Asp Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp 
    1355                 1360                 1365             


Ser Ile  Ser Arg Tyr Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn 
    1370                 1375                 1380             


Phe Ser  Glu Thr Glu Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Glu Val  Glu Glu Gln Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser 
    1400                 1405                 1410             


Lys Lys  Glu Val Asp Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met 
    1415                 1420                 1425             


Phe Gln  Ile Tyr Asn Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr 
    1430                 1435                 1440             


Pro Asn  Leu His Thr Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn 
    1445                 1450                 1455             


Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met 
    1460                 1465                 1470             


Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu Val Val  His Pro Ala 
    1475                 1480                 1485             


Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr 
    1490                 1495                 1500             


Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu 
    1505                 1510                 1515             


Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro 
    1520                 1525                 1530             


Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys 
    1535                 1540                 1545             


His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile Asp Arg  Gly Glu Arg 
    1550                 1555                 1560             


Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly Lys Gly  Asn Ile Val 
    1565                 1570                 1575             


Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile 
    1580                 1585                 1590             


Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys 
    1595                 1600                 1605             


Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile 
    1610                 1615                 1620             


Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln Val Val  His Lys Ile 
    1625                 1630                 1635             


Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val Ile Ala  Leu Glu Asp 
    1640                 1645                 1650             


Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln 
    1655                 1660                 1665             


Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr 
    1670                 1675                 1680             


Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu 
    1685                 1690                 1695             


Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met 
    1700                 1705                 1710             


Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr 
    1715                 1720                 1725             


Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr 
    1730                 1735                 1740             


Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe 
    1745                 1750                 1755             


Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala 
    1760                 1765                 1770             


Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys 
    1775                 1780                 1785             


Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg 
    1790                 1795                 1800             


Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu 
    1805                 1810                 1815             


Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr 
    1820                 1825                 1830             


Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys 
    1835                 1840                 1845             


Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met Ser Leu  Met Leu Gln 
    1850                 1855                 1860             


Met Ala  Asn Ser Ile Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile 
    1865                 1870                 1875             


Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn 
    1880                 1885                 1890             


Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala 
    1895                 1900                 1905             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly 
    1910                 1915                 1920             


Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile 
    1925                 1930                 1935             


Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val 
    1940                 1945                 1950             


Lys His  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  73
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  73

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Thr 
    1250                 1255                 1260             


Leu Asn  Ile Glu Asp Glu Tyr  Arg Leu His Glu Thr  Ser Lys Glu 
    1265                 1270                 1275             


Pro Asp  Val Ser Leu Gly Ser  Thr Trp Leu Ser Asp  Phe Pro Gln 
    1280                 1285                 1290             


Ala Trp  Ala Glu Thr Gly Gly  Met Gly Leu Ala Val  Arg Gln Ala 
    1295                 1300                 1305             


Pro Leu  Ile Ile Pro Leu Lys  Ala Thr Ser Thr Pro  Val Ser Ile 
    1310                 1315                 1320             


Lys Gln  Tyr Pro Met Ser Gln  Glu Ala Arg Leu Gly  Ile Lys Pro 
    1325                 1330                 1335             


His Ile  Gln Arg Leu Leu Asp  Gln Gly Ile Leu Val  Pro Cys Gln 
    1340                 1345                 1350             


Ser Pro  Trp Asn Thr Pro Leu  Leu Pro Val Lys Lys  Pro Gly Thr 
    1355                 1360                 1365             


Asn Asp  Tyr Arg Pro Val Gln  Asp Leu Arg Glu Val  Asn Lys Arg 
    1370                 1375                 1380             


Val Glu  Asp Ile His Pro Thr  Val Pro Asn Pro Tyr  Asn Leu Leu 
    1385                 1390                 1395             


Ser Gly  Leu Pro Pro Ser His  Gln Trp Tyr Thr Val  Leu Asp Leu 
    1400                 1405                 1410             


Lys Asp  Ala Phe Phe Cys Leu  Arg Leu His Pro Thr  Ser Gln Pro 
    1415                 1420                 1425             


Leu Phe  Ala Phe Glu Trp Arg  Asp Pro Glu Met Gly  Ile Ser Gly 
    1430                 1435                 1440             


Gln Leu  Thr Trp Thr Arg Leu  Pro Gln Gly Phe Lys  Asn Ser Pro 
    1445                 1450                 1455             


Thr Leu  Phe Asn Glu Ala Leu  His Arg Asp Leu Ala  Asp Phe Arg 
    1460                 1465                 1470             


Ile Gln  His Pro Asp Leu Ile  Leu Leu Gln Tyr Val  Asp Asp Leu 
    1475                 1480                 1485             


Leu Leu  Ala Ala Thr Ser Glu  Leu Asp Cys Gln Gln  Gly Thr Arg 
    1490                 1495                 1500             


Ala Leu  Leu Gln Thr Leu Gly  Asn Leu Gly Tyr Arg  Ala Ser Ala 
    1505                 1510                 1515             


Lys Lys  Ala Gln Ile Cys Gln  Lys Gln Val Lys Tyr  Leu Gly Tyr 
    1520                 1525                 1530             


Leu Leu  Lys Glu Gly Gln Arg  Trp Leu Thr Glu Ala  Arg Lys Glu 
    1535                 1540                 1545             


Thr Val  Met Gly Gln Pro Thr  Pro Lys Thr Pro Arg  Gln Leu Arg 
    1550                 1555                 1560             


Glu Phe  Leu Gly Lys Ala Gly  Phe Cys Arg Leu Phe  Ile Pro Gly 
    1565                 1570                 1575             


Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro Leu Thr  Lys Pro Gly 
    1580                 1585                 1590             


Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln Lys Ala  Tyr Gln Glu 
    1595                 1600                 1605             


Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala Leu Gly  Leu Pro Asp 
    1610                 1615                 1620             


Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp Glu Lys  Gln Gly Tyr 
    1625                 1630                 1635             


Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly Pro Trp  Arg Arg Pro 
    1640                 1645                 1650             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro Val Ala  Ala Gly Trp 
    1655                 1660                 1665             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Val  Leu Thr Lys 
    1670                 1675                 1680             


Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro Leu Val  Ile Leu Ala 
    1685                 1690                 1695             


Pro His  Ala Val Glu Ala Leu  Val Lys Gln Pro Pro  Asp Arg Trp 
    1700                 1705                 1710             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Leu  Leu Leu Asp 
    1715                 1720                 1725             


Thr Asp  Arg Val Gln Phe Gly  Pro Val Val Ala Leu  Asn Pro Ala 
    1730                 1735                 1740             


Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu Gln His  Asn Cys Leu 
    1745                 1750                 1755             


Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg Pro Asp  Leu Thr Asp 
    1760                 1765                 1770             


Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp Tyr Thr  Asp Gly Ser 
    1775                 1780                 1785             


Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala Gly Ala  Ala Val Thr 
    1790                 1795                 1800             


Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala Leu Pro  Ala Gly Thr 
    1805                 1810                 1815             


Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu Thr Gln  Ala Leu Lys 
    1820                 1825                 1830             


Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr Thr Asp  Ser Arg Tyr 
    1835                 1840                 1845             


Ala Phe  Ala Thr Ala His Ile  His Gly Glu Ile Tyr  Arg Arg Arg 
    1850                 1855                 1860             


Gly Trp  Leu Thr Ser Glu Gly  Lys Glu Ile Lys Asn  Lys Asp Glu 
    1865                 1870                 1875             


Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu Pro Lys  Arg Leu Ser 
    1880                 1885                 1890             


Ile Ile  His Cys Pro Gly His  Gln Lys Gly His Ser  Ala Glu Ala 
    1895                 1900                 1905             


Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala Arg Lys  Ala Ala Ile 
    1910                 1915                 1920             


Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu Ile Glu  Asn Ser Ser 
    1925                 1930                 1935             


Pro Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  74
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  74

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1250                 1255                 1260             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1265                 1270                 1275             


Thr Leu  Asn Ile Glu Asp Glu  Tyr Arg Leu His Glu  Thr Ser Lys 
    1280                 1285                 1290             


Glu Pro  Asp Val Ser Leu Gly  Ser Thr Trp Leu Ser  Asp Phe Pro 
    1295                 1300                 1305             


Gln Ala  Trp Ala Glu Thr Gly  Gly Met Gly Leu Ala  Val Arg Gln 
    1310                 1315                 1320             


Ala Pro  Leu Ile Ile Pro Leu  Lys Ala Thr Ser Thr  Pro Val Ser 
    1325                 1330                 1335             


Ile Lys  Gln Tyr Pro Met Ser  Gln Glu Ala Arg Leu  Gly Ile Lys 
    1340                 1345                 1350             


Pro His  Ile Gln Arg Leu Leu  Asp Gln Gly Ile Leu  Val Pro Cys 
    1355                 1360                 1365             


Gln Ser  Pro Trp Asn Thr Pro  Leu Leu Pro Val Lys  Lys Pro Gly 
    1370                 1375                 1380             


Thr Asn  Asp Tyr Arg Pro Val  Gln Asp Leu Arg Glu  Val Asn Lys 
    1385                 1390                 1395             


Arg Val  Glu Asp Ile His Pro  Thr Val Pro Asn Pro  Tyr Asn Leu 
    1400                 1405                 1410             


Leu Ser  Gly Leu Pro Pro Ser  His Gln Trp Tyr Thr  Val Leu Asp 
    1415                 1420                 1425             


Leu Lys  Asp Ala Phe Phe Cys  Leu Arg Leu His Pro  Thr Ser Gln 
    1430                 1435                 1440             


Pro Leu  Phe Ala Phe Glu Trp  Arg Asp Pro Glu Met  Gly Ile Ser 
    1445                 1450                 1455             


Gly Gln  Leu Thr Trp Thr Arg  Leu Pro Gln Gly Phe  Lys Asn Ser 
    1460                 1465                 1470             


Pro Thr  Leu Phe Asn Glu Ala  Leu His Arg Asp Leu  Ala Asp Phe 
    1475                 1480                 1485             


Arg Ile  Gln His Pro Asp Leu  Ile Leu Leu Gln Tyr  Val Asp Asp 
    1490                 1495                 1500             


Leu Leu  Leu Ala Ala Thr Ser  Glu Leu Asp Cys Gln  Gln Gly Thr 
    1505                 1510                 1515             


Arg Ala  Leu Leu Gln Thr Leu  Gly Asn Leu Gly Tyr  Arg Ala Ser 
    1520                 1525                 1530             


Ala Lys  Lys Ala Gln Ile Cys  Gln Lys Gln Val Lys  Tyr Leu Gly 
    1535                 1540                 1545             


Tyr Leu  Leu Lys Glu Gly Gln  Arg Trp Leu Thr Glu  Ala Arg Lys 
    1550                 1555                 1560             


Glu Thr  Val Met Gly Gln Pro  Thr Pro Lys Thr Pro  Arg Gln Leu 
    1565                 1570                 1575             


Arg Glu  Phe Leu Gly Lys Ala  Gly Phe Cys Arg Leu  Phe Ile Pro 
    1580                 1585                 1590             


Gly Phe  Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Pro 
    1595                 1600                 1605             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1610                 1615                 1620             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1625                 1630                 1635             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1640                 1645                 1650             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1655                 1660                 1665             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1670                 1675                 1680             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1685                 1690                 1695             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1700                 1705                 1710             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1715                 1720                 1725             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1730                 1735                 1740             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1745                 1750                 1755             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1760                 1765                 1770             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1775                 1780                 1785             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly 
    1790                 1795                 1800             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1805                 1810                 1815             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1820                 1825                 1830             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1835                 1840                 1845             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1850                 1855                 1860             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1865                 1870                 1875             


Arg Gly  Trp Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1880                 1885                 1890             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1895                 1900                 1905             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1910                 1915                 1920             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1925                 1930                 1935             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ile  Glu Asn Ser 
    1940                 1945                 1950             


Ser Pro  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  75
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  75

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Ser Glu Thr Pro Gly Thr 
    690                 695                 700                 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Lys Leu Glu Lys Phe Thr Asn 
705                 710                 715                 720 


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
                725                 730                 735     


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
            740                 745                 750         


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
        755                 760                 765             


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
    770                 775                 780                 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
785                 790                 795                 800 


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
                805                 810                 815     


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
            820                 825                 830         


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
        835                 840                 845             


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
    850                 855                 860                 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
865                 870                 875                 880 


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
                885                 890                 895     


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
            900                 905                 910         


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
        915                 920                 925             


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
    930                 935                 940                 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
945                 950                 955                 960 


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
                965                 970                 975     


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
            980                 985                 990         


Ser Asp Arg Glu Ser Leu Ser Phe  Tyr Gly Glu Gly Tyr  Thr Ser Asp 
        995                 1000                 1005             


Glu Glu  Val Leu Glu Val Phe  Arg Asn Thr Leu Asn  Lys Asn Ser 
    1010                 1015                 1020             


Glu Ile  Phe Ser Ser Ile Lys  Lys Leu Glu Lys Leu  Phe Lys Asn 
    1025                 1030                 1035             


Phe Asp  Glu Tyr Ser Ser Ala  Gly Ile Phe Val Lys  Asn Gly Pro 
    1040                 1045                 1050             


Ala Ile  Ser Thr Ile Ser Lys  Asp Ile Phe Gly Glu  Trp Asn Val 
    1055                 1060                 1065             


Ile Arg  Asp Lys Trp Asn Ala  Glu Tyr Asp Asp Ile  His Leu Lys 
    1070                 1075                 1080             


Lys Lys  Ala Val Val Thr Glu  Lys Tyr Glu Asp Asp  Arg Arg Lys 
    1085                 1090                 1095             


Ser Phe  Lys Lys Ile Gly Ser  Phe Ser Leu Glu Gln  Leu Gln Glu 
    1100                 1105                 1110             


Tyr Ala  Asp Ala Asp Leu Ser  Val Val Glu Lys Leu  Lys Glu Ile 
    1115                 1120                 1125             


Ile Ile  Gln Lys Val Asp Glu  Ile Tyr Lys Val Tyr  Gly Ser Ser 
    1130                 1135                 1140             


Glu Lys  Leu Phe Asp Ala Asp  Phe Val Leu Glu Lys  Ser Leu Lys 
    1145                 1150                 1155             


Lys Asn  Asp Ala Val Val Ala  Ile Met Lys Asp Leu  Leu Asp Ser 
    1160                 1165                 1170             


Val Lys  Ser Phe Glu Asn Tyr  Ile Lys Ala Phe Phe  Gly Glu Gly 
    1175                 1180                 1185             


Lys Glu  Thr Asn Arg Asp Glu  Ser Phe Tyr Gly Asp  Phe Val Leu 
    1190                 1195                 1200             


Ala Tyr  Asp Ile Leu Leu Lys  Val Asp His Ile Tyr  Asp Ala Ile 
    1205                 1210                 1215             


Arg Asn  Tyr Val Thr Gln Lys  Pro Tyr Ser Lys Asp  Lys Phe Lys 
    1220                 1225                 1230             


Leu Tyr  Phe Gln Asn Pro Gln  Phe Met Arg Gly Trp  Asp Lys Asp 
    1235                 1240                 1245             


Lys Glu  Thr Asp Tyr Arg Ala  Thr Ile Leu Arg Tyr  Gly Ser Lys 
    1250                 1255                 1260             


Tyr Tyr  Leu Ala Ile Met Asp  Lys Lys Tyr Ala Lys  Cys Leu Gln 
    1265                 1270                 1275             


Lys Ile  Asp Lys Asp Asp Val  Asn Gly Asn Tyr Glu  Lys Ile Asn 
    1280                 1285                 1290             


Tyr Lys  Leu Leu Pro Gly Pro  Asn Lys Met Leu Pro  Arg Val Phe 
    1295                 1300                 1305             


Phe Ser  Lys Lys Trp Met Ala  Tyr Tyr Asn Pro Ser  Glu Asp Ile 
    1310                 1315                 1320             


Gln Lys  Ile Tyr Lys Asn Gly  Thr Phe Lys Lys Gly  Asp Met Phe 
    1325                 1330                 1335             


Asn Leu  Asn Asp Cys His Lys  Leu Ile Asp Phe Phe  Lys Asp Ser 
    1340                 1345                 1350             


Ile Ser  Arg Tyr Pro Lys Trp  Ser Asn Ala Tyr Asp  Phe Asn Phe 
    1355                 1360                 1365             


Ser Glu  Thr Glu Lys Tyr Lys  Asp Ile Ala Gly Phe  Tyr Arg Glu 
    1370                 1375                 1380             


Val Glu  Glu Gln Gly Tyr Lys  Val Ser Phe Glu Ser  Ala Ser Lys 
    1385                 1390                 1395             


Lys Glu  Val Asp Lys Leu Val  Glu Glu Gly Lys Leu  Tyr Met Phe 
    1400                 1405                 1410             


Gln Ile  Tyr Asn Lys Asp Phe  Ser Asp Lys Ser His  Gly Thr Pro 
    1415                 1420                 1425             


Asn Leu  His Thr Met Tyr Phe  Lys Leu Leu Phe Asp  Glu Asn Asn 
    1430                 1435                 1440             


His Gly  Gln Ile Arg Leu Ser  Gly Gly Ala Glu Leu  Phe Met Arg 
    1445                 1450                 1455             


Arg Ala  Ser Leu Lys Lys Glu  Glu Leu Val Val Ala  Pro Ala Asn 
    1460                 1465                 1470             


Ser Pro  Ile Ala Asn Lys Asn  Pro Asp Asn Pro Lys  Lys Thr Thr 
    1475                 1480                 1485             


Thr Leu  Ser Tyr Asp Val Tyr  Lys Asp Lys Arg Phe  Ser Glu Asp 
    1490                 1495                 1500             


Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile Asn Lys  Cys Pro Lys 
    1505                 1510                 1515             


Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg Val Leu  Leu Lys His 
    1520                 1525                 1530             


Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Asp Arg Gly  Glu Arg Asn 
    1535                 1540                 1545             


Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys Gly Asn  Ile Val Glu 
    1550                 1555                 1560             


Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn Phe Asn  Gly Ile Arg 
    1565                 1570                 1575             


Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp Lys Lys  Glu Lys Glu 
    1580                 1585                 1590             


Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser Ile Glu  Asn Ile Lys 
    1595                 1600                 1605             


Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val Val His  Lys Ile Cys 
    1610                 1615                 1620             


Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu 
    1625                 1630                 1635             


Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys Val Glu  Lys Gln Val 
    1640                 1645                 1650             


Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met 
    1655                 1660                 1665             


Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys 
    1670                 1675                 1680             


Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser 
    1685                 1690                 1695             


Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
    1700                 1705                 1710             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1715                 1720                 1725             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1730                 1735                 1740             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1745                 1750                 1755             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1760                 1765                 1770             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1775                 1780                 1785             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1790                 1795                 1800             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1805                 1810                 1815             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1820                 1825                 1830             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1835                 1840                 1845             


Ala Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1850                 1855                 1860             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1865                 1870                 1875             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1880                 1885                 1890             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1895                 1900                 1905             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1910                 1915                 1920             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1925                 1930                 1935             


His Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  76
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  76

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Ser Gly Gly Ser 
    690                 695                 700                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn 
                725                 730                 735     


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
            740                 745                 750         


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
        755                 760                 765             


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
    770                 775                 780                 


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
                805                 810                 815     


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
            820                 825                 830         


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
        835                 840                 845             


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
    850                 855                 860                 


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
865                 870                 875                 880 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
                885                 890                 895     


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
            900                 905                 910         


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
        915                 920                 925             


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
    930                 935                 940                 


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
945                 950                 955                 960 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
                965                 970                 975     


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            980                 985                 990         


Thr Lys Gln Lys Leu Pro Lys Phe  Lys Pro Leu Tyr Lys  Gln Val Leu 
        995                 1000                 1005             


Ser Asp  Arg Glu Ser Leu Ser  Phe Tyr Gly Glu Gly  Tyr Thr Ser 
    1010                 1015                 1020             


Asp Glu  Glu Val Leu Glu Val  Phe Arg Asn Thr Leu  Asn Lys Asn 
    1025                 1030                 1035             


Ser Glu  Ile Phe Ser Ser Ile  Lys Lys Leu Glu Lys  Leu Phe Lys 
    1040                 1045                 1050             


Asn Phe  Asp Glu Tyr Ser Ser  Ala Gly Ile Phe Val  Lys Asn Gly 
    1055                 1060                 1065             


Pro Ala  Ile Ser Thr Ile Ser  Lys Asp Ile Phe Gly  Glu Trp Asn 
    1070                 1075                 1080             


Val Ile  Arg Asp Lys Trp Asn  Ala Glu Tyr Asp Asp  Ile His Leu 
    1085                 1090                 1095             


Lys Lys  Lys Ala Val Val Thr  Glu Lys Tyr Glu Asp  Asp Arg Arg 
    1100                 1105                 1110             


Lys Ser  Phe Lys Lys Ile Gly  Ser Phe Ser Leu Glu  Gln Leu Gln 
    1115                 1120                 1125             


Glu Tyr  Ala Asp Ala Asp Leu  Ser Val Val Glu Lys  Leu Lys Glu 
    1130                 1135                 1140             


Ile Ile  Ile Gln Lys Val Asp  Glu Ile Tyr Lys Val  Tyr Gly Ser 
    1145                 1150                 1155             


Ser Glu  Lys Leu Phe Asp Ala  Asp Phe Val Leu Glu  Lys Ser Leu 
    1160                 1165                 1170             


Lys Lys  Asn Asp Ala Val Val  Ala Ile Met Lys Asp  Leu Leu Asp 
    1175                 1180                 1185             


Ser Val  Lys Ser Phe Glu Asn  Tyr Ile Lys Ala Phe  Phe Gly Glu 
    1190                 1195                 1200             


Gly Lys  Glu Thr Asn Arg Asp  Glu Ser Phe Tyr Gly  Asp Phe Val 
    1205                 1210                 1215             


Leu Ala  Tyr Asp Ile Leu Leu  Lys Val Asp His Ile  Tyr Asp Ala 
    1220                 1225                 1230             


Ile Arg  Asn Tyr Val Thr Gln  Lys Pro Tyr Ser Lys  Asp Lys Phe 
    1235                 1240                 1245             


Lys Leu  Tyr Phe Gln Asn Pro  Gln Phe Met Arg Gly  Trp Asp Lys 
    1250                 1255                 1260             


Asp Lys  Glu Thr Asp Tyr Arg  Ala Thr Ile Leu Arg  Tyr Gly Ser 
    1265                 1270                 1275             


Lys Tyr  Tyr Leu Ala Ile Met  Asp Lys Lys Tyr Ala  Lys Cys Leu 
    1280                 1285                 1290             


Gln Lys  Ile Asp Lys Asp Asp  Val Asn Gly Asn Tyr  Glu Lys Ile 
    1295                 1300                 1305             


Asn Tyr  Lys Leu Leu Pro Gly  Pro Asn Lys Met Leu  Pro Arg Val 
    1310                 1315                 1320             


Phe Phe  Ser Lys Lys Trp Met  Ala Tyr Tyr Asn Pro  Ser Glu Asp 
    1325                 1330                 1335             


Ile Gln  Lys Ile Tyr Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met 
    1340                 1345                 1350             


Phe Asn  Leu Asn Asp Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp 
    1355                 1360                 1365             


Ser Ile  Ser Arg Tyr Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn 
    1370                 1375                 1380             


Phe Ser  Glu Thr Glu Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Glu Val  Glu Glu Gln Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser 
    1400                 1405                 1410             


Lys Lys  Glu Val Asp Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met 
    1415                 1420                 1425             


Phe Gln  Ile Tyr Asn Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr 
    1430                 1435                 1440             


Pro Asn  Leu His Thr Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn 
    1445                 1450                 1455             


Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met 
    1460                 1465                 1470             


Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu Val Val  Ala Pro Ala 
    1475                 1480                 1485             


Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr 
    1490                 1495                 1500             


Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu 
    1505                 1510                 1515             


Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro 
    1520                 1525                 1530             


Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys 
    1535                 1540                 1545             


His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile Asp Arg  Gly Glu Arg 
    1550                 1555                 1560             


Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly Lys Gly  Asn Ile Val 
    1565                 1570                 1575             


Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile 
    1580                 1585                 1590             


Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys 
    1595                 1600                 1605             


Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile 
    1610                 1615                 1620             


Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln Val Val  His Lys Ile 
    1625                 1630                 1635             


Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val Ile Ala  Leu Glu Asp 
    1640                 1645                 1650             


Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln 
    1655                 1660                 1665             


Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr 
    1670                 1675                 1680             


Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu 
    1685                 1690                 1695             


Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met 
    1700                 1705                 1710             


Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr 
    1715                 1720                 1725             


Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr 
    1730                 1735                 1740             


Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe 
    1745                 1750                 1755             


Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala 
    1760                 1765                 1770             


Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys 
    1775                 1780                 1785             


Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg 
    1790                 1795                 1800             


Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu 
    1805                 1810                 1815             


Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr 
    1820                 1825                 1830             


Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys 
    1835                 1840                 1845             


Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met Ser Leu  Met Leu Gln 
    1850                 1855                 1860             


Met Ala  Asn Ser Ile Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile 
    1865                 1870                 1875             


Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn 
    1880                 1885                 1890             


Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala 
    1895                 1900                 1905             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly 
    1910                 1915                 1920             


Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile 
    1925                 1930                 1935             


Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val 
    1940                 1945                 1950             


Lys His  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  77
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  77

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Arg Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Arg Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Thr 
    1250                 1255                 1260             


Leu Asn  Ile Glu Asp Glu Tyr  Arg Leu His Glu Thr  Ser Lys Glu 
    1265                 1270                 1275             


Pro Asp  Val Ser Leu Gly Ser  Thr Trp Leu Ser Asp  Phe Pro Gln 
    1280                 1285                 1290             


Ala Trp  Ala Glu Thr Gly Gly  Met Gly Leu Ala Val  Arg Gln Ala 
    1295                 1300                 1305             


Pro Leu  Ile Ile Pro Leu Lys  Ala Thr Ser Thr Pro  Val Ser Ile 
    1310                 1315                 1320             


Lys Gln  Tyr Pro Met Ser Gln  Glu Ala Arg Leu Gly  Ile Lys Pro 
    1325                 1330                 1335             


His Ile  Gln Arg Leu Leu Asp  Gln Gly Ile Leu Val  Pro Cys Gln 
    1340                 1345                 1350             


Ser Pro  Trp Asn Thr Pro Leu  Leu Pro Val Lys Lys  Pro Gly Thr 
    1355                 1360                 1365             


Asn Asp  Tyr Arg Pro Val Gln  Asp Leu Arg Glu Val  Asn Lys Arg 
    1370                 1375                 1380             


Val Glu  Asp Ile His Pro Thr  Val Pro Asn Pro Tyr  Asn Leu Leu 
    1385                 1390                 1395             


Ser Gly  Leu Pro Pro Ser His  Gln Trp Tyr Thr Val  Leu Asp Leu 
    1400                 1405                 1410             


Lys Asp  Ala Phe Phe Cys Leu  Arg Leu His Pro Thr  Ser Gln Pro 
    1415                 1420                 1425             


Leu Phe  Ala Phe Glu Trp Arg  Asp Pro Glu Met Gly  Ile Ser Gly 
    1430                 1435                 1440             


Gln Leu  Thr Trp Thr Arg Leu  Pro Gln Gly Phe Lys  Asn Ser Pro 
    1445                 1450                 1455             


Thr Leu  Phe Asn Glu Ala Leu  His Arg Asp Leu Ala  Asp Phe Arg 
    1460                 1465                 1470             


Ile Gln  His Pro Asp Leu Ile  Leu Leu Gln Tyr Val  Asp Asp Leu 
    1475                 1480                 1485             


Leu Leu  Ala Ala Thr Ser Glu  Leu Asp Cys Gln Gln  Gly Thr Arg 
    1490                 1495                 1500             


Ala Leu  Leu Gln Thr Leu Gly  Asn Leu Gly Tyr Arg  Ala Ser Ala 
    1505                 1510                 1515             


Lys Lys  Ala Gln Ile Cys Gln  Lys Gln Val Lys Tyr  Leu Gly Tyr 
    1520                 1525                 1530             


Leu Leu  Lys Glu Gly Gln Arg  Trp Leu Thr Glu Ala  Arg Lys Glu 
    1535                 1540                 1545             


Thr Val  Met Gly Gln Pro Thr  Pro Lys Thr Pro Arg  Gln Leu Arg 
    1550                 1555                 1560             


Glu Phe  Leu Gly Lys Ala Gly  Phe Cys Arg Leu Phe  Ile Pro Gly 
    1565                 1570                 1575             


Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro Leu Thr  Lys Pro Gly 
    1580                 1585                 1590             


Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln Lys Ala  Tyr Gln Glu 
    1595                 1600                 1605             


Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala Leu Gly  Leu Pro Asp 
    1610                 1615                 1620             


Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp Glu Lys  Gln Gly Tyr 
    1625                 1630                 1635             


Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly Pro Trp  Arg Arg Pro 
    1640                 1645                 1650             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro Val Ala  Ala Gly Trp 
    1655                 1660                 1665             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Val  Leu Thr Lys 
    1670                 1675                 1680             


Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro Leu Val  Ile Leu Ala 
    1685                 1690                 1695             


Pro His  Ala Val Glu Ala Leu  Val Lys Gln Pro Pro  Asp Arg Trp 
    1700                 1705                 1710             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Leu  Leu Leu Asp 
    1715                 1720                 1725             


Thr Asp  Arg Val Gln Phe Gly  Pro Val Val Ala Leu  Asn Pro Ala 
    1730                 1735                 1740             


Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu Gln His  Asn Cys Leu 
    1745                 1750                 1755             


Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg Pro Asp  Leu Thr Asp 
    1760                 1765                 1770             


Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp Tyr Thr  Asp Gly Ser 
    1775                 1780                 1785             


Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala Gly Ala  Ala Val Thr 
    1790                 1795                 1800             


Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala Leu Pro  Ala Gly Thr 
    1805                 1810                 1815             


Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu Thr Gln  Ala Leu Lys 
    1820                 1825                 1830             


Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr Thr Asp  Ser Arg Tyr 
    1835                 1840                 1845             


Ala Phe  Ala Thr Ala His Ile  His Gly Glu Ile Tyr  Arg Arg Arg 
    1850                 1855                 1860             


Gly Trp  Leu Thr Ser Glu Gly  Lys Glu Ile Lys Asn  Lys Asp Glu 
    1865                 1870                 1875             


Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu Pro Lys  Arg Leu Ser 
    1880                 1885                 1890             


Ile Ile  His Cys Pro Gly His  Gln Lys Gly His Ser  Ala Glu Ala 
    1895                 1900                 1905             


Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala Arg Lys  Ala Ala Ile 
    1910                 1915                 1920             


Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu Ile Glu  Asn Ser Ser 
    1925                 1930                 1935             


Pro Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  78
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  78

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Arg Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Arg Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1250                 1255                 1260             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1265                 1270                 1275             


Thr Leu  Asn Ile Glu Asp Glu  Tyr Arg Leu His Glu  Thr Ser Lys 
    1280                 1285                 1290             


Glu Pro  Asp Val Ser Leu Gly  Ser Thr Trp Leu Ser  Asp Phe Pro 
    1295                 1300                 1305             


Gln Ala  Trp Ala Glu Thr Gly  Gly Met Gly Leu Ala  Val Arg Gln 
    1310                 1315                 1320             


Ala Pro  Leu Ile Ile Pro Leu  Lys Ala Thr Ser Thr  Pro Val Ser 
    1325                 1330                 1335             


Ile Lys  Gln Tyr Pro Met Ser  Gln Glu Ala Arg Leu  Gly Ile Lys 
    1340                 1345                 1350             


Pro His  Ile Gln Arg Leu Leu  Asp Gln Gly Ile Leu  Val Pro Cys 
    1355                 1360                 1365             


Gln Ser  Pro Trp Asn Thr Pro  Leu Leu Pro Val Lys  Lys Pro Gly 
    1370                 1375                 1380             


Thr Asn  Asp Tyr Arg Pro Val  Gln Asp Leu Arg Glu  Val Asn Lys 
    1385                 1390                 1395             


Arg Val  Glu Asp Ile His Pro  Thr Val Pro Asn Pro  Tyr Asn Leu 
    1400                 1405                 1410             


Leu Ser  Gly Leu Pro Pro Ser  His Gln Trp Tyr Thr  Val Leu Asp 
    1415                 1420                 1425             


Leu Lys  Asp Ala Phe Phe Cys  Leu Arg Leu His Pro  Thr Ser Gln 
    1430                 1435                 1440             


Pro Leu  Phe Ala Phe Glu Trp  Arg Asp Pro Glu Met  Gly Ile Ser 
    1445                 1450                 1455             


Gly Gln  Leu Thr Trp Thr Arg  Leu Pro Gln Gly Phe  Lys Asn Ser 
    1460                 1465                 1470             


Pro Thr  Leu Phe Asn Glu Ala  Leu His Arg Asp Leu  Ala Asp Phe 
    1475                 1480                 1485             


Arg Ile  Gln His Pro Asp Leu  Ile Leu Leu Gln Tyr  Val Asp Asp 
    1490                 1495                 1500             


Leu Leu  Leu Ala Ala Thr Ser  Glu Leu Asp Cys Gln  Gln Gly Thr 
    1505                 1510                 1515             


Arg Ala  Leu Leu Gln Thr Leu  Gly Asn Leu Gly Tyr  Arg Ala Ser 
    1520                 1525                 1530             


Ala Lys  Lys Ala Gln Ile Cys  Gln Lys Gln Val Lys  Tyr Leu Gly 
    1535                 1540                 1545             


Tyr Leu  Leu Lys Glu Gly Gln  Arg Trp Leu Thr Glu  Ala Arg Lys 
    1550                 1555                 1560             


Glu Thr  Val Met Gly Gln Pro  Thr Pro Lys Thr Pro  Arg Gln Leu 
    1565                 1570                 1575             


Arg Glu  Phe Leu Gly Lys Ala  Gly Phe Cys Arg Leu  Phe Ile Pro 
    1580                 1585                 1590             


Gly Phe  Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Pro 
    1595                 1600                 1605             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1610                 1615                 1620             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1625                 1630                 1635             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1640                 1645                 1650             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1655                 1660                 1665             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1670                 1675                 1680             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1685                 1690                 1695             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1700                 1705                 1710             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1715                 1720                 1725             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1730                 1735                 1740             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1745                 1750                 1755             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1760                 1765                 1770             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1775                 1780                 1785             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly 
    1790                 1795                 1800             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1805                 1810                 1815             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1820                 1825                 1830             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1835                 1840                 1845             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1850                 1855                 1860             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1865                 1870                 1875             


Arg Gly  Trp Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1880                 1885                 1890             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1895                 1900                 1905             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1910                 1915                 1920             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1925                 1930                 1935             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ile  Glu Asn Ser 
    1940                 1945                 1950             


Ser Pro  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  79
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  79

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Ser Glu Thr Pro Gly Thr 
    690                 695                 700                 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Lys Leu Glu Lys Phe Thr Asn 
705                 710                 715                 720 


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
                725                 730                 735     


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
            740                 745                 750         


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
        755                 760                 765             


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
    770                 775                 780                 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
785                 790                 795                 800 


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
                805                 810                 815     


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
            820                 825                 830         


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
        835                 840                 845             


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
    850                 855                 860                 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
865                 870                 875                 880 


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
                885                 890                 895     


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
            900                 905                 910         


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
        915                 920                 925             


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
    930                 935                 940                 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
945                 950                 955                 960 


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
                965                 970                 975     


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
            980                 985                 990         


Ser Asp Arg Glu Ser Leu Ser Phe  Tyr Gly Glu Gly Tyr  Thr Ser Asp 
        995                 1000                 1005             


Glu Glu  Val Leu Glu Val Phe  Arg Asn Thr Leu Asn  Lys Asn Ser 
    1010                 1015                 1020             


Glu Ile  Phe Ser Ser Ile Lys  Lys Leu Glu Lys Leu  Phe Lys Asn 
    1025                 1030                 1035             


Phe Asp  Glu Tyr Ser Ser Ala  Gly Ile Phe Val Lys  Asn Gly Pro 
    1040                 1045                 1050             


Ala Ile  Ser Thr Ile Ser Lys  Asp Ile Phe Gly Glu  Trp Asn Val 
    1055                 1060                 1065             


Ile Arg  Asp Lys Trp Asn Ala  Glu Tyr Asp Asp Ile  His Leu Lys 
    1070                 1075                 1080             


Lys Lys  Ala Val Val Thr Glu  Lys Tyr Glu Asp Asp  Arg Arg Lys 
    1085                 1090                 1095             


Ser Phe  Lys Lys Ile Gly Ser  Phe Ser Leu Glu Gln  Leu Gln Glu 
    1100                 1105                 1110             


Tyr Ala  Asp Ala Asp Leu Ser  Val Val Glu Lys Leu  Lys Glu Ile 
    1115                 1120                 1125             


Ile Ile  Gln Lys Val Asp Glu  Ile Tyr Lys Val Tyr  Gly Ser Ser 
    1130                 1135                 1140             


Glu Lys  Leu Phe Asp Ala Asp  Phe Val Leu Glu Lys  Ser Leu Lys 
    1145                 1150                 1155             


Lys Asn  Asp Ala Val Val Ala  Ile Met Lys Asp Leu  Leu Asp Ser 
    1160                 1165                 1170             


Val Lys  Ser Phe Glu Asn Tyr  Ile Lys Ala Phe Phe  Gly Glu Gly 
    1175                 1180                 1185             


Lys Glu  Thr Asn Arg Asp Glu  Ser Phe Tyr Gly Asp  Phe Val Leu 
    1190                 1195                 1200             


Ala Tyr  Asp Ile Leu Leu Lys  Val Asp His Ile Tyr  Asp Ala Ile 
    1205                 1210                 1215             


Arg Asn  Tyr Val Thr Gln Lys  Pro Tyr Ser Lys Asp  Lys Phe Lys 
    1220                 1225                 1230             


Leu Tyr  Phe Gln Asn Pro Gln  Phe Met Arg Gly Trp  Asp Lys Asp 
    1235                 1240                 1245             


Val Glu  Thr Asp Tyr Arg Ala  Thr Ile Leu Arg Tyr  Gly Ser Lys 
    1250                 1255                 1260             


Tyr Tyr  Leu Ala Ile Met Asp  Lys Lys Tyr Ala Lys  Cys Leu Gln 
    1265                 1270                 1275             


Lys Ile  Asp Lys Asp Asp Val  Asn Gly Asn Tyr Glu  Lys Ile Asn 
    1280                 1285                 1290             


Tyr Lys  Leu Leu Pro Gly Pro  Asn Lys Met Leu Pro  Arg Val Phe 
    1295                 1300                 1305             


Phe Ser  Lys Lys Trp Met Ala  Tyr Tyr Asn Pro Ser  Glu Asp Ile 
    1310                 1315                 1320             


Gln Lys  Ile Tyr Lys Asn Gly  Thr Phe Lys Lys Gly  Asp Met Phe 
    1325                 1330                 1335             


Asn Leu  Asn Asp Cys His Lys  Leu Ile Asp Phe Phe  Lys Asp Ser 
    1340                 1345                 1350             


Ile Ser  Arg Tyr Pro Lys Trp  Ser Asn Ala Tyr Asp  Phe Asn Phe 
    1355                 1360                 1365             


Ser Glu  Thr Glu Lys Tyr Lys  Asp Ile Ala Gly Phe  Tyr Arg Glu 
    1370                 1375                 1380             


Val Glu  Glu Gln Gly Tyr Lys  Val Ser Phe Glu Ser  Ala Ser Lys 
    1385                 1390                 1395             


Lys Glu  Val Asp Lys Leu Val  Glu Glu Gly Lys Leu  Tyr Met Phe 
    1400                 1405                 1410             


Gln Ile  Tyr Asn Lys Asp Phe  Ser Asp Lys Ser His  Gly Thr Pro 
    1415                 1420                 1425             


Asn Leu  His Thr Met Tyr Phe  Lys Leu Leu Phe Asp  Glu Asn Asn 
    1430                 1435                 1440             


His Gly  Gln Ile Arg Leu Ser  Gly Gly Ala Glu Leu  Phe Met Arg 
    1445                 1450                 1455             


Arg Ala  Ser Leu Lys Lys Glu  Glu Leu Val Val Ala  Pro Ala Asn 
    1460                 1465                 1470             


Ser Pro  Ile Ala Asn Lys Asn  Pro Asp Asn Pro Lys  Lys Thr Thr 
    1475                 1480                 1485             


Thr Leu  Ser Tyr Asp Val Tyr  Lys Asp Lys Arg Phe  Ser Glu Asp 
    1490                 1495                 1500             


Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile Asn Lys  Cys Pro Lys 
    1505                 1510                 1515             


Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg Val Leu  Leu Lys His 
    1520                 1525                 1530             


Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Asp Arg Gly  Glu Arg Asn 
    1535                 1540                 1545             


Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys Gly Asn  Ile Val Glu 
    1550                 1555                 1560             


Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn Phe Asn  Gly Ile Arg 
    1565                 1570                 1575             


Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp Lys Lys  Glu Lys Glu 
    1580                 1585                 1590             


Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser Ile Glu  Asn Ile Lys 
    1595                 1600                 1605             


Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val Val His  Lys Ile Cys 
    1610                 1615                 1620             


Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu 
    1625                 1630                 1635             


Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys Val Glu  Lys Gln Val 
    1640                 1645                 1650             


Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met 
    1655                 1660                 1665             


Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys 
    1670                 1675                 1680             


Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser 
    1685                 1690                 1695             


Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
    1700                 1705                 1710             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1715                 1720                 1725             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1730                 1735                 1740             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1745                 1750                 1755             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1760                 1765                 1770             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1775                 1780                 1785             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1790                 1795                 1800             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1805                 1810                 1815             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1820                 1825                 1830             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1835                 1840                 1845             


Ala Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1850                 1855                 1860             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1865                 1870                 1875             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1880                 1885                 1890             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1895                 1900                 1905             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1910                 1915                 1920             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1925                 1930                 1935             


His Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  80
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  80

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Ser Gly Gly Ser 
    690                 695                 700                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn 
                725                 730                 735     


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
            740                 745                 750         


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
        755                 760                 765             


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
    770                 775                 780                 


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
                805                 810                 815     


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
            820                 825                 830         


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
        835                 840                 845             


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
    850                 855                 860                 


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
865                 870                 875                 880 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
                885                 890                 895     


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
            900                 905                 910         


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
        915                 920                 925             


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
    930                 935                 940                 


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
945                 950                 955                 960 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
                965                 970                 975     


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            980                 985                 990         


Thr Lys Gln Lys Leu Pro Lys Phe  Lys Pro Leu Tyr Lys  Gln Val Leu 
        995                 1000                 1005             


Ser Asp  Arg Glu Ser Leu Ser  Phe Tyr Gly Glu Gly  Tyr Thr Ser 
    1010                 1015                 1020             


Asp Glu  Glu Val Leu Glu Val  Phe Arg Asn Thr Leu  Asn Lys Asn 
    1025                 1030                 1035             


Ser Glu  Ile Phe Ser Ser Ile  Lys Lys Leu Glu Lys  Leu Phe Lys 
    1040                 1045                 1050             


Asn Phe  Asp Glu Tyr Ser Ser  Ala Gly Ile Phe Val  Lys Asn Gly 
    1055                 1060                 1065             


Pro Ala  Ile Ser Thr Ile Ser  Lys Asp Ile Phe Gly  Glu Trp Asn 
    1070                 1075                 1080             


Val Ile  Arg Asp Lys Trp Asn  Ala Glu Tyr Asp Asp  Ile His Leu 
    1085                 1090                 1095             


Lys Lys  Lys Ala Val Val Thr  Glu Lys Tyr Glu Asp  Asp Arg Arg 
    1100                 1105                 1110             


Lys Ser  Phe Lys Lys Ile Gly  Ser Phe Ser Leu Glu  Gln Leu Gln 
    1115                 1120                 1125             


Glu Tyr  Ala Asp Ala Asp Leu  Ser Val Val Glu Lys  Leu Lys Glu 
    1130                 1135                 1140             


Ile Ile  Ile Gln Lys Val Asp  Glu Ile Tyr Lys Val  Tyr Gly Ser 
    1145                 1150                 1155             


Ser Glu  Lys Leu Phe Asp Ala  Asp Phe Val Leu Glu  Lys Ser Leu 
    1160                 1165                 1170             


Lys Lys  Asn Asp Ala Val Val  Ala Ile Met Lys Asp  Leu Leu Asp 
    1175                 1180                 1185             


Ser Val  Lys Ser Phe Glu Asn  Tyr Ile Lys Ala Phe  Phe Gly Glu 
    1190                 1195                 1200             


Gly Lys  Glu Thr Asn Arg Asp  Glu Ser Phe Tyr Gly  Asp Phe Val 
    1205                 1210                 1215             


Leu Ala  Tyr Asp Ile Leu Leu  Lys Val Asp His Ile  Tyr Asp Ala 
    1220                 1225                 1230             


Ile Arg  Asn Tyr Val Thr Gln  Lys Pro Tyr Ser Lys  Asp Lys Phe 
    1235                 1240                 1245             


Lys Leu  Tyr Phe Gln Asn Pro  Gln Phe Met Arg Gly  Trp Asp Lys 
    1250                 1255                 1260             


Asp Val  Glu Thr Asp Tyr Arg  Ala Thr Ile Leu Arg  Tyr Gly Ser 
    1265                 1270                 1275             


Lys Tyr  Tyr Leu Ala Ile Met  Asp Lys Lys Tyr Ala  Lys Cys Leu 
    1280                 1285                 1290             


Gln Lys  Ile Asp Lys Asp Asp  Val Asn Gly Asn Tyr  Glu Lys Ile 
    1295                 1300                 1305             


Asn Tyr  Lys Leu Leu Pro Gly  Pro Asn Lys Met Leu  Pro Arg Val 
    1310                 1315                 1320             


Phe Phe  Ser Lys Lys Trp Met  Ala Tyr Tyr Asn Pro  Ser Glu Asp 
    1325                 1330                 1335             


Ile Gln  Lys Ile Tyr Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met 
    1340                 1345                 1350             


Phe Asn  Leu Asn Asp Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp 
    1355                 1360                 1365             


Ser Ile  Ser Arg Tyr Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn 
    1370                 1375                 1380             


Phe Ser  Glu Thr Glu Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Glu Val  Glu Glu Gln Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser 
    1400                 1405                 1410             


Lys Lys  Glu Val Asp Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met 
    1415                 1420                 1425             


Phe Gln  Ile Tyr Asn Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr 
    1430                 1435                 1440             


Pro Asn  Leu His Thr Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn 
    1445                 1450                 1455             


Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met 
    1460                 1465                 1470             


Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu Val Val  Ala Pro Ala 
    1475                 1480                 1485             


Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr 
    1490                 1495                 1500             


Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu 
    1505                 1510                 1515             


Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro 
    1520                 1525                 1530             


Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys 
    1535                 1540                 1545             


His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile Asp Arg  Gly Glu Arg 
    1550                 1555                 1560             


Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly Lys Gly  Asn Ile Val 
    1565                 1570                 1575             


Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile 
    1580                 1585                 1590             


Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys 
    1595                 1600                 1605             


Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile 
    1610                 1615                 1620             


Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln Val Val  His Lys Ile 
    1625                 1630                 1635             


Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val Ile Ala  Leu Glu Asp 
    1640                 1645                 1650             


Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln 
    1655                 1660                 1665             


Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr 
    1670                 1675                 1680             


Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu 
    1685                 1690                 1695             


Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met 
    1700                 1705                 1710             


Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr 
    1715                 1720                 1725             


Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr 
    1730                 1735                 1740             


Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe 
    1745                 1750                 1755             


Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala 
    1760                 1765                 1770             


Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys 
    1775                 1780                 1785             


Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg 
    1790                 1795                 1800             


Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu 
    1805                 1810                 1815             


Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr 
    1820                 1825                 1830             


Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys 
    1835                 1840                 1845             


Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met Ser Leu  Met Leu Gln 
    1850                 1855                 1860             


Met Ala  Asn Ser Ile Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile 
    1865                 1870                 1875             


Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn 
    1880                 1885                 1890             


Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala 
    1895                 1900                 1905             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly 
    1910                 1915                 1920             


Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile 
    1925                 1930                 1935             


Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val 
    1940                 1945                 1950             


Lys His  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  81
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  81

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Arg Gly Trp Asp Lys Asp Val Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Arg Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Thr 
    1250                 1255                 1260             


Leu Asn  Ile Glu Asp Glu Tyr  Arg Leu His Glu Thr  Ser Lys Glu 
    1265                 1270                 1275             


Pro Asp  Val Ser Leu Gly Ser  Thr Trp Leu Ser Asp  Phe Pro Gln 
    1280                 1285                 1290             


Ala Trp  Ala Glu Thr Gly Gly  Met Gly Leu Ala Val  Arg Gln Ala 
    1295                 1300                 1305             


Pro Leu  Ile Ile Pro Leu Lys  Ala Thr Ser Thr Pro  Val Ser Ile 
    1310                 1315                 1320             


Lys Gln  Tyr Pro Met Ser Gln  Glu Ala Arg Leu Gly  Ile Lys Pro 
    1325                 1330                 1335             


His Ile  Gln Arg Leu Leu Asp  Gln Gly Ile Leu Val  Pro Cys Gln 
    1340                 1345                 1350             


Ser Pro  Trp Asn Thr Pro Leu  Leu Pro Val Lys Lys  Pro Gly Thr 
    1355                 1360                 1365             


Asn Asp  Tyr Arg Pro Val Gln  Asp Leu Arg Glu Val  Asn Lys Arg 
    1370                 1375                 1380             


Val Glu  Asp Ile His Pro Thr  Val Pro Asn Pro Tyr  Asn Leu Leu 
    1385                 1390                 1395             


Ser Gly  Leu Pro Pro Ser His  Gln Trp Tyr Thr Val  Leu Asp Leu 
    1400                 1405                 1410             


Lys Asp  Ala Phe Phe Cys Leu  Arg Leu His Pro Thr  Ser Gln Pro 
    1415                 1420                 1425             


Leu Phe  Ala Phe Glu Trp Arg  Asp Pro Glu Met Gly  Ile Ser Gly 
    1430                 1435                 1440             


Gln Leu  Thr Trp Thr Arg Leu  Pro Gln Gly Phe Lys  Asn Ser Pro 
    1445                 1450                 1455             


Thr Leu  Phe Asn Glu Ala Leu  His Arg Asp Leu Ala  Asp Phe Arg 
    1460                 1465                 1470             


Ile Gln  His Pro Asp Leu Ile  Leu Leu Gln Tyr Val  Asp Asp Leu 
    1475                 1480                 1485             


Leu Leu  Ala Ala Thr Ser Glu  Leu Asp Cys Gln Gln  Gly Thr Arg 
    1490                 1495                 1500             


Ala Leu  Leu Gln Thr Leu Gly  Asn Leu Gly Tyr Arg  Ala Ser Ala 
    1505                 1510                 1515             


Lys Lys  Ala Gln Ile Cys Gln  Lys Gln Val Lys Tyr  Leu Gly Tyr 
    1520                 1525                 1530             


Leu Leu  Lys Glu Gly Gln Arg  Trp Leu Thr Glu Ala  Arg Lys Glu 
    1535                 1540                 1545             


Thr Val  Met Gly Gln Pro Thr  Pro Lys Thr Pro Arg  Gln Leu Arg 
    1550                 1555                 1560             


Glu Phe  Leu Gly Lys Ala Gly  Phe Cys Arg Leu Phe  Ile Pro Gly 
    1565                 1570                 1575             


Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro Leu Thr  Lys Pro Gly 
    1580                 1585                 1590             


Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln Lys Ala  Tyr Gln Glu 
    1595                 1600                 1605             


Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala Leu Gly  Leu Pro Asp 
    1610                 1615                 1620             


Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp Glu Lys  Gln Gly Tyr 
    1625                 1630                 1635             


Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly Pro Trp  Arg Arg Pro 
    1640                 1645                 1650             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro Val Ala  Ala Gly Trp 
    1655                 1660                 1665             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Val  Leu Thr Lys 
    1670                 1675                 1680             


Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro Leu Val  Ile Leu Ala 
    1685                 1690                 1695             


Pro His  Ala Val Glu Ala Leu  Val Lys Gln Pro Pro  Asp Arg Trp 
    1700                 1705                 1710             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Leu  Leu Leu Asp 
    1715                 1720                 1725             


Thr Asp  Arg Val Gln Phe Gly  Pro Val Val Ala Leu  Asn Pro Ala 
    1730                 1735                 1740             


Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu Gln His  Asn Cys Leu 
    1745                 1750                 1755             


Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg Pro Asp  Leu Thr Asp 
    1760                 1765                 1770             


Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp Tyr Thr  Asp Gly Ser 
    1775                 1780                 1785             


Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala Gly Ala  Ala Val Thr 
    1790                 1795                 1800             


Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala Leu Pro  Ala Gly Thr 
    1805                 1810                 1815             


Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu Thr Gln  Ala Leu Lys 
    1820                 1825                 1830             


Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr Thr Asp  Ser Arg Tyr 
    1835                 1840                 1845             


Ala Phe  Ala Thr Ala His Ile  His Gly Glu Ile Tyr  Arg Arg Arg 
    1850                 1855                 1860             


Gly Trp  Leu Thr Ser Glu Gly  Lys Glu Ile Lys Asn  Lys Asp Glu 
    1865                 1870                 1875             


Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu Pro Lys  Arg Leu Ser 
    1880                 1885                 1890             


Ile Ile  His Cys Pro Gly His  Gln Lys Gly His Ser  Ala Glu Ala 
    1895                 1900                 1905             


Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala Arg Lys  Ala Ala Ile 
    1910                 1915                 1920             


Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu Ile Glu  Asn Ser Ser 
    1925                 1930                 1935             


Pro Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  82
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  82

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Arg Gly Trp Asp Lys Asp Val Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Arg Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1250                 1255                 1260             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1265                 1270                 1275             


Thr Leu  Asn Ile Glu Asp Glu  Tyr Arg Leu His Glu  Thr Ser Lys 
    1280                 1285                 1290             


Glu Pro  Asp Val Ser Leu Gly  Ser Thr Trp Leu Ser  Asp Phe Pro 
    1295                 1300                 1305             


Gln Ala  Trp Ala Glu Thr Gly  Gly Met Gly Leu Ala  Val Arg Gln 
    1310                 1315                 1320             


Ala Pro  Leu Ile Ile Pro Leu  Lys Ala Thr Ser Thr  Pro Val Ser 
    1325                 1330                 1335             


Ile Lys  Gln Tyr Pro Met Ser  Gln Glu Ala Arg Leu  Gly Ile Lys 
    1340                 1345                 1350             


Pro His  Ile Gln Arg Leu Leu  Asp Gln Gly Ile Leu  Val Pro Cys 
    1355                 1360                 1365             


Gln Ser  Pro Trp Asn Thr Pro  Leu Leu Pro Val Lys  Lys Pro Gly 
    1370                 1375                 1380             


Thr Asn  Asp Tyr Arg Pro Val  Gln Asp Leu Arg Glu  Val Asn Lys 
    1385                 1390                 1395             


Arg Val  Glu Asp Ile His Pro  Thr Val Pro Asn Pro  Tyr Asn Leu 
    1400                 1405                 1410             


Leu Ser  Gly Leu Pro Pro Ser  His Gln Trp Tyr Thr  Val Leu Asp 
    1415                 1420                 1425             


Leu Lys  Asp Ala Phe Phe Cys  Leu Arg Leu His Pro  Thr Ser Gln 
    1430                 1435                 1440             


Pro Leu  Phe Ala Phe Glu Trp  Arg Asp Pro Glu Met  Gly Ile Ser 
    1445                 1450                 1455             


Gly Gln  Leu Thr Trp Thr Arg  Leu Pro Gln Gly Phe  Lys Asn Ser 
    1460                 1465                 1470             


Pro Thr  Leu Phe Asn Glu Ala  Leu His Arg Asp Leu  Ala Asp Phe 
    1475                 1480                 1485             


Arg Ile  Gln His Pro Asp Leu  Ile Leu Leu Gln Tyr  Val Asp Asp 
    1490                 1495                 1500             


Leu Leu  Leu Ala Ala Thr Ser  Glu Leu Asp Cys Gln  Gln Gly Thr 
    1505                 1510                 1515             


Arg Ala  Leu Leu Gln Thr Leu  Gly Asn Leu Gly Tyr  Arg Ala Ser 
    1520                 1525                 1530             


Ala Lys  Lys Ala Gln Ile Cys  Gln Lys Gln Val Lys  Tyr Leu Gly 
    1535                 1540                 1545             


Tyr Leu  Leu Lys Glu Gly Gln  Arg Trp Leu Thr Glu  Ala Arg Lys 
    1550                 1555                 1560             


Glu Thr  Val Met Gly Gln Pro  Thr Pro Lys Thr Pro  Arg Gln Leu 
    1565                 1570                 1575             


Arg Glu  Phe Leu Gly Lys Ala  Gly Phe Cys Arg Leu  Phe Ile Pro 
    1580                 1585                 1590             


Gly Phe  Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Pro 
    1595                 1600                 1605             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1610                 1615                 1620             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1625                 1630                 1635             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1640                 1645                 1650             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1655                 1660                 1665             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1670                 1675                 1680             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1685                 1690                 1695             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1700                 1705                 1710             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1715                 1720                 1725             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1730                 1735                 1740             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1745                 1750                 1755             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1760                 1765                 1770             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1775                 1780                 1785             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly 
    1790                 1795                 1800             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1805                 1810                 1815             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1820                 1825                 1830             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1835                 1840                 1845             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1850                 1855                 1860             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1865                 1870                 1875             


Arg Gly  Trp Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1880                 1885                 1890             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1895                 1900                 1905             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1910                 1915                 1920             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1925                 1930                 1935             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ile  Glu Asn Ser 
    1940                 1945                 1950             


Ser Pro  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  83
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  83

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Ser Glu Thr Pro Gly Thr 
    690                 695                 700                 


Ser Glu Ser Ala Thr Pro Glu Ser Ser Lys Leu Glu Lys Phe Thr Asn 
705                 710                 715                 720 


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
                725                 730                 735     


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
            740                 745                 750         


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
        755                 760                 765             


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
    770                 775                 780                 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
785                 790                 795                 800 


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
                805                 810                 815     


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
            820                 825                 830         


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
        835                 840                 845             


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
    850                 855                 860                 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
865                 870                 875                 880 


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
                885                 890                 895     


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
            900                 905                 910         


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
        915                 920                 925             


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
    930                 935                 940                 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
945                 950                 955                 960 


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
                965                 970                 975     


Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu 
            980                 985                 990         


Ser Asp Arg Glu Ser Leu Ser Phe  Tyr Gly Glu Gly Tyr  Thr Ser Asp 
        995                 1000                 1005             


Glu Glu  Val Leu Glu Val Phe  Arg Asn Thr Leu Asn  Lys Asn Ser 
    1010                 1015                 1020             


Glu Ile  Phe Ser Ser Ile Lys  Lys Leu Glu Lys Leu  Phe Lys Asn 
    1025                 1030                 1035             


Phe Asp  Glu Tyr Ser Ser Ala  Gly Ile Phe Val Lys  Asn Gly Pro 
    1040                 1045                 1050             


Ala Ile  Ser Thr Ile Ser Lys  Asp Ile Phe Gly Glu  Trp Asn Val 
    1055                 1060                 1065             


Ile Arg  Asp Lys Trp Asn Ala  Glu Tyr Asp Asp Ile  His Leu Lys 
    1070                 1075                 1080             


Lys Lys  Ala Val Val Thr Glu  Lys Tyr Glu Asp Asp  Arg Arg Lys 
    1085                 1090                 1095             


Ser Phe  Lys Lys Ile Gly Ser  Phe Ser Leu Glu Gln  Leu Gln Glu 
    1100                 1105                 1110             


Tyr Ala  Asp Ala Asp Leu Ser  Val Val Glu Lys Leu  Lys Glu Ile 
    1115                 1120                 1125             


Ile Ile  Gln Lys Val Asp Glu  Ile Tyr Lys Val Tyr  Gly Ser Ser 
    1130                 1135                 1140             


Glu Lys  Leu Phe Asp Ala Asp  Phe Val Leu Glu Lys  Ser Leu Lys 
    1145                 1150                 1155             


Lys Asn  Asp Ala Val Val Ala  Ile Met Lys Asp Leu  Leu Asp Ser 
    1160                 1165                 1170             


Val Lys  Ser Phe Glu Asn Tyr  Ile Lys Ala Phe Phe  Gly Glu Gly 
    1175                 1180                 1185             


Lys Glu  Thr Asn Arg Asp Glu  Ser Phe Tyr Gly Asp  Phe Val Leu 
    1190                 1195                 1200             


Ala Tyr  Asp Ile Leu Leu Lys  Val Asp His Ile Tyr  Asp Ala Ile 
    1205                 1210                 1215             


Arg Asn  Tyr Val Thr Gln Lys  Pro Tyr Ser Lys Asp  Lys Phe Lys 
    1220                 1225                 1230             


Leu Tyr  Phe Gln Asn Pro Gln  Phe Met Gly Gly Trp  Asp Lys Asp 
    1235                 1240                 1245             


Lys Glu  Thr Asp Tyr Arg Ala  Thr Ile Leu Arg Tyr  Gly Ser Lys 
    1250                 1255                 1260             


Tyr Tyr  Leu Ala Ile Met Asp  Lys Lys Tyr Ala Lys  Cys Leu Gln 
    1265                 1270                 1275             


Lys Ile  Asp Lys Asp Asp Val  Asn Gly Asn Tyr Glu  Lys Ile Asn 
    1280                 1285                 1290             


Tyr Lys  Leu Leu Pro Gly Pro  Asn Lys Met Leu Pro  Lys Val Phe 
    1295                 1300                 1305             


Phe Ser  Lys Lys Trp Met Ala  Tyr Tyr Asn Pro Ser  Glu Asp Ile 
    1310                 1315                 1320             


Gln Lys  Ile Tyr Lys Asn Gly  Thr Phe Lys Lys Gly  Asp Met Phe 
    1325                 1330                 1335             


Asn Leu  Asn Asp Cys His Lys  Leu Ile Asp Phe Phe  Lys Asp Ser 
    1340                 1345                 1350             


Ile Ser  Arg Tyr Pro Lys Trp  Ser Asn Ala Tyr Asp  Phe Asn Phe 
    1355                 1360                 1365             


Ser Glu  Thr Glu Lys Tyr Lys  Asp Ile Ala Gly Phe  Tyr Arg Glu 
    1370                 1375                 1380             


Val Glu  Glu Gln Gly Tyr Lys  Val Ser Phe Glu Ser  Ala Ser Lys 
    1385                 1390                 1395             


Lys Glu  Val Asp Lys Leu Val  Glu Glu Gly Lys Leu  Tyr Met Phe 
    1400                 1405                 1410             


Gln Ile  Tyr Asn Lys Asp Phe  Ser Asp Lys Ser His  Gly Thr Pro 
    1415                 1420                 1425             


Asn Leu  His Thr Met Tyr Phe  Lys Leu Leu Phe Asp  Glu Asn Asn 
    1430                 1435                 1440             


His Gly  Gln Ile Arg Leu Ser  Gly Gly Ala Glu Leu  Phe Met Arg 
    1445                 1450                 1455             


Arg Ala  Ser Leu Lys Lys Glu  Glu Leu Val Val Ala  Pro Ala Asn 
    1460                 1465                 1470             


Ser Pro  Ile Ala Asn Lys Asn  Pro Asp Asn Pro Lys  Lys Thr Thr 
    1475                 1480                 1485             


Thr Leu  Ser Tyr Asp Val Tyr  Lys Asp Lys Arg Phe  Ser Glu Asp 
    1490                 1495                 1500             


Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile Asn Lys  Cys Pro Lys 
    1505                 1510                 1515             


Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg Val Leu  Leu Lys His 
    1520                 1525                 1530             


Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Asp Arg Gly  Glu Arg Asn 
    1535                 1540                 1545             


Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys Gly Asn  Ile Val Glu 
    1550                 1555                 1560             


Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn Phe Asn  Gly Ile Arg 
    1565                 1570                 1575             


Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp Lys Lys  Glu Lys Glu 
    1580                 1585                 1590             


Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser Ile Glu  Asn Ile Lys 
    1595                 1600                 1605             


Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val Val His  Lys Ile Cys 
    1610                 1615                 1620             


Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile Ala Leu  Glu Asp Leu 
    1625                 1630                 1635             


Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys Val Glu  Lys Gln Val 
    1640                 1645                 1650             


Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp Lys Leu  Asn Tyr Met 
    1655                 1660                 1665             


Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys 
    1670                 1675                 1680             


Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser 
    1685                 1690                 1695             


Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser 
    1700                 1705                 1710             


Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys 
    1715                 1720                 1725             


Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp 
    1730                 1735                 1740             


Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu 
    1745                 1750                 1755             


Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys 
    1760                 1765                 1770             


Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn 
    1775                 1780                 1785             


Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr 
    1790                 1795                 1800             


Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln 
    1805                 1810                 1815             


Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala 
    1820                 1825                 1830             


Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser Leu Met  Leu Gln Met 
    1835                 1840                 1845             


Ala Asn  Ser Ile Thr Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser 
    1850                 1855                 1860             


Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr 
    1865                 1870                 1875             


Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn 
    1880                 1885                 1890             


Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln 
    1895                 1900                 1905             


Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala 
    1910                 1915                 1920             


Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys 
    1925                 1930                 1935             


His Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  84
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  84

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Ser Gly Gly Ser 
    690                 695                 700                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
705                 710                 715                 720 


Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys Phe Thr Asn 
                725                 730                 735     


Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly 
            740                 745                 750         


Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu 
        755                 760                 765             


Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr 
    770                 775                 780                 


Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys 
                805                 810                 815     


Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile 
            820                 825                 830         


Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys 
        835                 840                 845             


Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu 
    850                 855                 860                 


Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly 
865                 870                 875                 880 


Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr 
                885                 890                 895     


Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser 
            900                 905                 910         


Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu 
        915                 920                 925             


Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu 
    930                 935                 940                 


Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly 
945                 950                 955                 960 


Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly 
                965                 970                 975     


Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys 
            980                 985                 990         


Thr Lys Gln Lys Leu Pro Lys Phe  Lys Pro Leu Tyr Lys  Gln Val Leu 
        995                 1000                 1005             


Ser Asp  Arg Glu Ser Leu Ser  Phe Tyr Gly Glu Gly  Tyr Thr Ser 
    1010                 1015                 1020             


Asp Glu  Glu Val Leu Glu Val  Phe Arg Asn Thr Leu  Asn Lys Asn 
    1025                 1030                 1035             


Ser Glu  Ile Phe Ser Ser Ile  Lys Lys Leu Glu Lys  Leu Phe Lys 
    1040                 1045                 1050             


Asn Phe  Asp Glu Tyr Ser Ser  Ala Gly Ile Phe Val  Lys Asn Gly 
    1055                 1060                 1065             


Pro Ala  Ile Ser Thr Ile Ser  Lys Asp Ile Phe Gly  Glu Trp Asn 
    1070                 1075                 1080             


Val Ile  Arg Asp Lys Trp Asn  Ala Glu Tyr Asp Asp  Ile His Leu 
    1085                 1090                 1095             


Lys Lys  Lys Ala Val Val Thr  Glu Lys Tyr Glu Asp  Asp Arg Arg 
    1100                 1105                 1110             


Lys Ser  Phe Lys Lys Ile Gly  Ser Phe Ser Leu Glu  Gln Leu Gln 
    1115                 1120                 1125             


Glu Tyr  Ala Asp Ala Asp Leu  Ser Val Val Glu Lys  Leu Lys Glu 
    1130                 1135                 1140             


Ile Ile  Ile Gln Lys Val Asp  Glu Ile Tyr Lys Val  Tyr Gly Ser 
    1145                 1150                 1155             


Ser Glu  Lys Leu Phe Asp Ala  Asp Phe Val Leu Glu  Lys Ser Leu 
    1160                 1165                 1170             


Lys Lys  Asn Asp Ala Val Val  Ala Ile Met Lys Asp  Leu Leu Asp 
    1175                 1180                 1185             


Ser Val  Lys Ser Phe Glu Asn  Tyr Ile Lys Ala Phe  Phe Gly Glu 
    1190                 1195                 1200             


Gly Lys  Glu Thr Asn Arg Asp  Glu Ser Phe Tyr Gly  Asp Phe Val 
    1205                 1210                 1215             


Leu Ala  Tyr Asp Ile Leu Leu  Lys Val Asp His Ile  Tyr Asp Ala 
    1220                 1225                 1230             


Ile Arg  Asn Tyr Val Thr Gln  Lys Pro Tyr Ser Lys  Asp Lys Phe 
    1235                 1240                 1245             


Lys Leu  Tyr Phe Gln Asn Pro  Gln Phe Met Gly Gly  Trp Asp Lys 
    1250                 1255                 1260             


Asp Lys  Glu Thr Asp Tyr Arg  Ala Thr Ile Leu Arg  Tyr Gly Ser 
    1265                 1270                 1275             


Lys Tyr  Tyr Leu Ala Ile Met  Asp Lys Lys Tyr Ala  Lys Cys Leu 
    1280                 1285                 1290             


Gln Lys  Ile Asp Lys Asp Asp  Val Asn Gly Asn Tyr  Glu Lys Ile 
    1295                 1300                 1305             


Asn Tyr  Lys Leu Leu Pro Gly  Pro Asn Lys Met Leu  Pro Lys Val 
    1310                 1315                 1320             


Phe Phe  Ser Lys Lys Trp Met  Ala Tyr Tyr Asn Pro  Ser Glu Asp 
    1325                 1330                 1335             


Ile Gln  Lys Ile Tyr Lys Asn  Gly Thr Phe Lys Lys  Gly Asp Met 
    1340                 1345                 1350             


Phe Asn  Leu Asn Asp Cys His  Lys Leu Ile Asp Phe  Phe Lys Asp 
    1355                 1360                 1365             


Ser Ile  Ser Arg Tyr Pro Lys  Trp Ser Asn Ala Tyr  Asp Phe Asn 
    1370                 1375                 1380             


Phe Ser  Glu Thr Glu Lys Tyr  Lys Asp Ile Ala Gly  Phe Tyr Arg 
    1385                 1390                 1395             


Glu Val  Glu Glu Gln Gly Tyr  Lys Val Ser Phe Glu  Ser Ala Ser 
    1400                 1405                 1410             


Lys Lys  Glu Val Asp Lys Leu  Val Glu Glu Gly Lys  Leu Tyr Met 
    1415                 1420                 1425             


Phe Gln  Ile Tyr Asn Lys Asp  Phe Ser Asp Lys Ser  His Gly Thr 
    1430                 1435                 1440             


Pro Asn  Leu His Thr Met Tyr  Phe Lys Leu Leu Phe  Asp Glu Asn 
    1445                 1450                 1455             


Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly Ala Glu  Leu Phe Met 
    1460                 1465                 1470             


Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu Val Val  Ala Pro Ala 
    1475                 1480                 1485             


Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp Asn Pro  Lys Lys Thr 
    1490                 1495                 1500             


Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp Lys Arg  Phe Ser Glu 
    1505                 1510                 1515             


Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala Ile Asn  Lys Cys Pro 
    1520                 1525                 1530             


Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val Arg Val  Leu Leu Lys 
    1535                 1540                 1545             


His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile Asp Arg  Gly Glu Arg 
    1550                 1555                 1560             


Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly Lys Gly  Asn Ile Val 
    1565                 1570                 1575             


Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn Asn Phe  Asn Gly Ile 
    1580                 1585                 1590             


Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu Asp Lys  Lys Glu Lys 
    1595                 1600                 1605             


Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr Ser Ile  Glu Asn Ile 
    1610                 1615                 1620             


Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln Val Val  His Lys Ile 
    1625                 1630                 1635             


Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val Ile Ala  Leu Glu Asp 
    1640                 1645                 1650             


Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val Lys Val  Glu Lys Gln 
    1655                 1660                 1665             


Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile Asp Lys  Leu Asn Tyr 
    1670                 1675                 1680             


Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala Thr Gly  Gly Ala Leu 
    1685                 1690                 1695             


Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu Ser Phe  Lys Ser Met 
    1700                 1705                 1710             


Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile Pro Ala  Trp Leu Thr 
    1715                 1720                 1725             


Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val Asn Leu  Leu Lys Thr 
    1730                 1735                 1740             


Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys Phe Ile  Ser Ser Phe 
    1745                 1750                 1755             


Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp Leu Phe  Glu Phe Ala 
    1760                 1765                 1770             


Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp Ala Asp  Tyr Ile Lys 
    1775                 1780                 1785             


Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg Ile Arg  Ile Phe Arg 
    1790                 1795                 1800             


Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp Glu Glu  Val Cys Leu 
    1805                 1810                 1815             


Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys Tyr Gly  Ile Asn Tyr 
    1820                 1825                 1830             


Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys Glu Gln  Ser Asp Lys 
    1835                 1840                 1845             


Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met Ser Leu  Met Leu Gln 
    1850                 1855                 1860             


Met Ala  Asn Ser Ile Thr Gly  Arg Thr Asp Val Asp  Phe Leu Ile 
    1865                 1870                 1875             


Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe Tyr Asp  Ser Arg Asn 
    1880                 1885                 1890             


Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro Lys Asn  Ala Asp Ala 
    1895                 1900                 1905             


Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val Leu Trp  Ala Ile Gly 
    1910                 1915                 1920             


Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu Asp Lys  Val Lys Ile 
    1925                 1930                 1935             


Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr Ala Gln  Thr Ser Val 
    1940                 1945                 1950             


Lys His  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  85
<211>  1963
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  85

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Thr 
    1250                 1255                 1260             


Leu Asn  Ile Glu Asp Glu Tyr  Arg Leu His Glu Thr  Ser Lys Glu 
    1265                 1270                 1275             


Pro Asp  Val Ser Leu Gly Ser  Thr Trp Leu Ser Asp  Phe Pro Gln 
    1280                 1285                 1290             


Ala Trp  Ala Glu Thr Gly Gly  Met Gly Leu Ala Val  Arg Gln Ala 
    1295                 1300                 1305             


Pro Leu  Ile Ile Pro Leu Lys  Ala Thr Ser Thr Pro  Val Ser Ile 
    1310                 1315                 1320             


Lys Gln  Tyr Pro Met Ser Gln  Glu Ala Arg Leu Gly  Ile Lys Pro 
    1325                 1330                 1335             


His Ile  Gln Arg Leu Leu Asp  Gln Gly Ile Leu Val  Pro Cys Gln 
    1340                 1345                 1350             


Ser Pro  Trp Asn Thr Pro Leu  Leu Pro Val Lys Lys  Pro Gly Thr 
    1355                 1360                 1365             


Asn Asp  Tyr Arg Pro Val Gln  Asp Leu Arg Glu Val  Asn Lys Arg 
    1370                 1375                 1380             


Val Glu  Asp Ile His Pro Thr  Val Pro Asn Pro Tyr  Asn Leu Leu 
    1385                 1390                 1395             


Ser Gly  Leu Pro Pro Ser His  Gln Trp Tyr Thr Val  Leu Asp Leu 
    1400                 1405                 1410             


Lys Asp  Ala Phe Phe Cys Leu  Arg Leu His Pro Thr  Ser Gln Pro 
    1415                 1420                 1425             


Leu Phe  Ala Phe Glu Trp Arg  Asp Pro Glu Met Gly  Ile Ser Gly 
    1430                 1435                 1440             


Gln Leu  Thr Trp Thr Arg Leu  Pro Gln Gly Phe Lys  Asn Ser Pro 
    1445                 1450                 1455             


Thr Leu  Phe Asn Glu Ala Leu  His Arg Asp Leu Ala  Asp Phe Arg 
    1460                 1465                 1470             


Ile Gln  His Pro Asp Leu Ile  Leu Leu Gln Tyr Val  Asp Asp Leu 
    1475                 1480                 1485             


Leu Leu  Ala Ala Thr Ser Glu  Leu Asp Cys Gln Gln  Gly Thr Arg 
    1490                 1495                 1500             


Ala Leu  Leu Gln Thr Leu Gly  Asn Leu Gly Tyr Arg  Ala Ser Ala 
    1505                 1510                 1515             


Lys Lys  Ala Gln Ile Cys Gln  Lys Gln Val Lys Tyr  Leu Gly Tyr 
    1520                 1525                 1530             


Leu Leu  Lys Glu Gly Gln Arg  Trp Leu Thr Glu Ala  Arg Lys Glu 
    1535                 1540                 1545             


Thr Val  Met Gly Gln Pro Thr  Pro Lys Thr Pro Arg  Gln Leu Arg 
    1550                 1555                 1560             


Glu Phe  Leu Gly Lys Ala Gly  Phe Cys Arg Leu Phe  Ile Pro Gly 
    1565                 1570                 1575             


Phe Ala  Glu Met Ala Ala Pro  Leu Tyr Pro Leu Thr  Lys Pro Gly 
    1580                 1585                 1590             


Thr Leu  Phe Asn Trp Gly Pro  Asp Gln Gln Lys Ala  Tyr Gln Glu 
    1595                 1600                 1605             


Ile Lys  Gln Ala Leu Leu Thr  Ala Pro Ala Leu Gly  Leu Pro Asp 
    1610                 1615                 1620             


Leu Thr  Lys Pro Phe Glu Leu  Phe Val Asp Glu Lys  Gln Gly Tyr 
    1625                 1630                 1635             


Ala Lys  Gly Val Leu Thr Gln  Lys Leu Gly Pro Trp  Arg Arg Pro 
    1640                 1645                 1650             


Val Ala  Tyr Leu Ser Lys Lys  Leu Asp Pro Val Ala  Ala Gly Trp 
    1655                 1660                 1665             


Pro Pro  Cys Leu Arg Met Val  Ala Ala Ile Ala Val  Leu Thr Lys 
    1670                 1675                 1680             


Asp Ala  Gly Lys Leu Thr Met  Gly Gln Pro Leu Val  Ile Leu Ala 
    1685                 1690                 1695             


Pro His  Ala Val Glu Ala Leu  Val Lys Gln Pro Pro  Asp Arg Trp 
    1700                 1705                 1710             


Leu Ser  Asn Ala Arg Met Thr  His Tyr Gln Ala Leu  Leu Leu Asp 
    1715                 1720                 1725             


Thr Asp  Arg Val Gln Phe Gly  Pro Val Val Ala Leu  Asn Pro Ala 
    1730                 1735                 1740             


Thr Leu  Leu Pro Leu Pro Glu  Glu Gly Leu Gln His  Asn Cys Leu 
    1745                 1750                 1755             


Asp Ile  Leu Ala Glu Ala His  Gly Thr Arg Pro Asp  Leu Thr Asp 
    1760                 1765                 1770             


Gln Pro  Leu Pro Asp Ala Asp  His Thr Trp Tyr Thr  Asp Gly Ser 
    1775                 1780                 1785             


Ser Leu  Leu Gln Glu Gly Gln  Arg Lys Ala Gly Ala  Ala Val Thr 
    1790                 1795                 1800             


Thr Glu  Thr Glu Val Ile Trp  Ala Lys Ala Leu Pro  Ala Gly Thr 
    1805                 1810                 1815             


Ser Ala  Gln Arg Ala Glu Leu  Ile Ala Leu Thr Gln  Ala Leu Lys 
    1820                 1825                 1830             


Met Ala  Glu Gly Lys Lys Leu  Asn Val Tyr Thr Asp  Ser Arg Tyr 
    1835                 1840                 1845             


Ala Phe  Ala Thr Ala His Ile  His Gly Glu Ile Tyr  Arg Arg Arg 
    1850                 1855                 1860             


Gly Trp  Leu Thr Ser Glu Gly  Lys Glu Ile Lys Asn  Lys Asp Glu 
    1865                 1870                 1875             


Ile Leu  Ala Leu Leu Lys Ala  Leu Phe Leu Pro Lys  Arg Leu Ser 
    1880                 1885                 1890             


Ile Ile  His Cys Pro Gly His  Gln Lys Gly His Ser  Ala Glu Ala 
    1895                 1900                 1905             


Arg Gly  Asn Arg Met Ala Asp  Gln Ala Ala Arg Lys  Ala Ala Ile 
    1910                 1915                 1920             


Thr Glu  Thr Pro Asp Thr Ser  Thr Leu Leu Ile Glu  Asn Ser Ser 
    1925                 1930                 1935             


Pro Ser  Gly Gly Ser Lys Arg  Thr Ala Asp Gly Ser  Glu Phe Glu 
    1940                 1945                 1950             


Pro Lys  Lys Lys Arg Lys Val  Gly Ser Gly 
    1955                 1960             


<210>  86
<211>  1979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  86

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Ala Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1250                 1255                 1260             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1265                 1270                 1275             


Thr Leu  Asn Ile Glu Asp Glu  Tyr Arg Leu His Glu  Thr Ser Lys 
    1280                 1285                 1290             


Glu Pro  Asp Val Ser Leu Gly  Ser Thr Trp Leu Ser  Asp Phe Pro 
    1295                 1300                 1305             


Gln Ala  Trp Ala Glu Thr Gly  Gly Met Gly Leu Ala  Val Arg Gln 
    1310                 1315                 1320             


Ala Pro  Leu Ile Ile Pro Leu  Lys Ala Thr Ser Thr  Pro Val Ser 
    1325                 1330                 1335             


Ile Lys  Gln Tyr Pro Met Ser  Gln Glu Ala Arg Leu  Gly Ile Lys 
    1340                 1345                 1350             


Pro His  Ile Gln Arg Leu Leu  Asp Gln Gly Ile Leu  Val Pro Cys 
    1355                 1360                 1365             


Gln Ser  Pro Trp Asn Thr Pro  Leu Leu Pro Val Lys  Lys Pro Gly 
    1370                 1375                 1380             


Thr Asn  Asp Tyr Arg Pro Val  Gln Asp Leu Arg Glu  Val Asn Lys 
    1385                 1390                 1395             


Arg Val  Glu Asp Ile His Pro  Thr Val Pro Asn Pro  Tyr Asn Leu 
    1400                 1405                 1410             


Leu Ser  Gly Leu Pro Pro Ser  His Gln Trp Tyr Thr  Val Leu Asp 
    1415                 1420                 1425             


Leu Lys  Asp Ala Phe Phe Cys  Leu Arg Leu His Pro  Thr Ser Gln 
    1430                 1435                 1440             


Pro Leu  Phe Ala Phe Glu Trp  Arg Asp Pro Glu Met  Gly Ile Ser 
    1445                 1450                 1455             


Gly Gln  Leu Thr Trp Thr Arg  Leu Pro Gln Gly Phe  Lys Asn Ser 
    1460                 1465                 1470             


Pro Thr  Leu Phe Asn Glu Ala  Leu His Arg Asp Leu  Ala Asp Phe 
    1475                 1480                 1485             


Arg Ile  Gln His Pro Asp Leu  Ile Leu Leu Gln Tyr  Val Asp Asp 
    1490                 1495                 1500             


Leu Leu  Leu Ala Ala Thr Ser  Glu Leu Asp Cys Gln  Gln Gly Thr 
    1505                 1510                 1515             


Arg Ala  Leu Leu Gln Thr Leu  Gly Asn Leu Gly Tyr  Arg Ala Ser 
    1520                 1525                 1530             


Ala Lys  Lys Ala Gln Ile Cys  Gln Lys Gln Val Lys  Tyr Leu Gly 
    1535                 1540                 1545             


Tyr Leu  Leu Lys Glu Gly Gln  Arg Trp Leu Thr Glu  Ala Arg Lys 
    1550                 1555                 1560             


Glu Thr  Val Met Gly Gln Pro  Thr Pro Lys Thr Pro  Arg Gln Leu 
    1565                 1570                 1575             


Arg Glu  Phe Leu Gly Lys Ala  Gly Phe Cys Arg Leu  Phe Ile Pro 
    1580                 1585                 1590             


Gly Phe  Ala Glu Met Ala Ala  Pro Leu Tyr Pro Leu  Thr Lys Pro 
    1595                 1600                 1605             


Gly Thr  Leu Phe Asn Trp Gly  Pro Asp Gln Gln Lys  Ala Tyr Gln 
    1610                 1615                 1620             


Glu Ile  Lys Gln Ala Leu Leu  Thr Ala Pro Ala Leu  Gly Leu Pro 
    1625                 1630                 1635             


Asp Leu  Thr Lys Pro Phe Glu  Leu Phe Val Asp Glu  Lys Gln Gly 
    1640                 1645                 1650             


Tyr Ala  Lys Gly Val Leu Thr  Gln Lys Leu Gly Pro  Trp Arg Arg 
    1655                 1660                 1665             


Pro Val  Ala Tyr Leu Ser Lys  Lys Leu Asp Pro Val  Ala Ala Gly 
    1670                 1675                 1680             


Trp Pro  Pro Cys Leu Arg Met  Val Ala Ala Ile Ala  Val Leu Thr 
    1685                 1690                 1695             


Lys Asp  Ala Gly Lys Leu Thr  Met Gly Gln Pro Leu  Val Ile Leu 
    1700                 1705                 1710             


Ala Pro  His Ala Val Glu Ala  Leu Val Lys Gln Pro  Pro Asp Arg 
    1715                 1720                 1725             


Trp Leu  Ser Asn Ala Arg Met  Thr His Tyr Gln Ala  Leu Leu Leu 
    1730                 1735                 1740             


Asp Thr  Asp Arg Val Gln Phe  Gly Pro Val Val Ala  Leu Asn Pro 
    1745                 1750                 1755             


Ala Thr  Leu Leu Pro Leu Pro  Glu Glu Gly Leu Gln  His Asn Cys 
    1760                 1765                 1770             


Leu Asp  Ile Leu Ala Glu Ala  His Gly Thr Arg Pro  Asp Leu Thr 
    1775                 1780                 1785             


Asp Gln  Pro Leu Pro Asp Ala  Asp His Thr Trp Tyr  Thr Asp Gly 
    1790                 1795                 1800             


Ser Ser  Leu Leu Gln Glu Gly  Gln Arg Lys Ala Gly  Ala Ala Val 
    1805                 1810                 1815             


Thr Thr  Glu Thr Glu Val Ile  Trp Ala Lys Ala Leu  Pro Ala Gly 
    1820                 1825                 1830             


Thr Ser  Ala Gln Arg Ala Glu  Leu Ile Ala Leu Thr  Gln Ala Leu 
    1835                 1840                 1845             


Lys Met  Ala Glu Gly Lys Lys  Leu Asn Val Tyr Thr  Asp Ser Arg 
    1850                 1855                 1860             


Tyr Ala  Phe Ala Thr Ala His  Ile His Gly Glu Ile  Tyr Arg Arg 
    1865                 1870                 1875             


Arg Gly  Trp Leu Thr Ser Glu  Gly Lys Glu Ile Lys  Asn Lys Asp 
    1880                 1885                 1890             


Glu Ile  Leu Ala Leu Leu Lys  Ala Leu Phe Leu Pro  Lys Arg Leu 
    1895                 1900                 1905             


Ser Ile  Ile His Cys Pro Gly  His Gln Lys Gly His  Ser Ala Glu 
    1910                 1915                 1920             


Ala Arg  Gly Asn Arg Met Ala  Asp Gln Ala Ala Arg  Lys Ala Ala 
    1925                 1930                 1935             


Ile Thr  Glu Thr Pro Asp Thr  Ser Thr Leu Leu Ile  Glu Asn Ser 
    1940                 1945                 1950             


Ser Pro  Ser Gly Gly Ser Lys  Arg Thr Ala Asp Gly  Ser Glu Phe 
    1955                 1960                 1965             


Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser Gly 
    1970                 1975                 


<210>  87
<211>  166
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic tagRNA

<400>  87
gtttcaaaga ttaaataatt tctactaagt gtagattacg gctccgcagt ggatggcggt       60

aatttctact aagtgtagat gcggcgcgtt gtttcatcaa ggcgtacggt caccgtaacc      120

agcaaatcaa tatcactgtg tggcttcagg ccgccatcca ctgcgg                     166


<210>  88
<211>  8019
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic plasmid

<400>  88
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctggttta gtgaaccgtc      600

agatccgcta gagatccgcg gccgctaata cgactcacta tagggagagc cgccaccatg      660

aaacggacag ccgacggaag cgagttcgag tcaccaaaga agaagcggaa agtctccaag      720

ctggagaagt ttacaaactg ttacagcctc tccaaaaccc tcaggtttaa agcgatcccg      780

gtgggcaaga cccaggagaa catcgacaac aagaggctcc tggtggaaga cgagaagcgc      840

gccgaagact acaagggcgt gaagaagctg ctcgataggt actacctcag ctttattaac      900

gacgtgctgc acagcatcaa actcaagaat ctcaacaact acatctccct cttccgcaaa      960

aagacccgca ccgagaagga gaacaaggag ctggagaacc tggagatcaa cctccgcaag     1020

gaaatcgcca aagcgttcaa gggcaatgaa gggtacaaga gcctcttcaa gaaagacatc     1080

atcgaaacta tcctcccaga gtttctcgat gacaaggacg agatcgcgct ggtgaactcc     1140

tttaacgggt tcacaaccgc gtttaccggc ttctttgata acagggaaaa tatgttctcc     1200

gaggaggcca agtccaccag catcgccttc aggtgtatca acgagaacct cacccgctac     1260

atttccaata tggacatttt cgagaaggtg gatgcgatct tcgataagca cgaggtgcag     1320

gagatcaaag agaagattct caattccgat tatgacgtcg aggatttctt cgaaggggag     1380

ttctttaatt ttgtgctcac acaagagggc attgacgtgt acaacgcgat tatcgggggc     1440

ttcgtcacag agtccgggga gaagattaag gggctgaatg agtacatcaa tctgtacaat     1500

cagaagacca agcagaaact gccgaaattc aagccgctct acaagcaagt cctgtccgat     1560

agggaaagcc tctccttcta cggcgagggc tataccagcg acgaggaggt gctggaagtc     1620

ttccgcaaca cactgaataa gaatagcgag attttctcct ccatcaagaa gctcgagaag     1680

ctctttaaga actttgacga gtacagctcc gccgggattt tcgtgaagaa cgggccggcg     1740

atcagcacca tctccaagga catctttggc gagtggaacg tcatcaggga caagtggaac     1800

gccgagtacg acgacatcca cctgaagaag aaggcggtgg tgaccgagaa gtatgaggac     1860

gatcgcagga agtccttcaa aaaaatcggc tccttcagcc tcgaacagct ccaggagtat     1920

gccgatgcgg atctgtccgt cgtcgagaag ctgaaggaaa tcatcattca gaaggtcgac     1980

gagatctata aagtgtacgg gtccagcgag aagctgttcg acgccgactt tgtgctcgag     2040

aagtccctca aaaagaatga cgccgtggtg gccattatga aagacctgct cgactccgtg     2100

aagtccttcg aaaattacat taaagcgttc tttggggagg ggaaggaaac taacagggat     2160

gagtccttct atggcgactt tgtcctcgcg tacgacatcc tgctgaaggt cgaccacatt     2220

tacgacgcga tccgcaacta cgtgacacag aagccgtact ccaaagacaa gttcaagctg     2280

tacttccaga acccgcaatt tatggggggc tgggacaagg ataaagagac agactaccgc     2340

gcgacaattc tccgctatgg ctccaaatac tatctggcca tcatggacaa gaagtacgcg     2400

aagtgcctgc agaagatcga caaagacgac gtcaatggca actatgaaaa gatcaactac     2460

aagctgctgc cgggcccgaa caagatgctc ccgaaggtgt tcttcagcaa gaagtggatg     2520

gcctactaca atccaagcga ggatattcag aaaatctata aaaacgggac cttcaagaag     2580

ggggacatgt ttaacctcaa cgactgccac aagctcattg atttcttcaa ggatagcatt     2640

tcccgctacc cgaaatggtc caatgcgtac gattttaact tctccgagac agaaaagtac     2700

aaagacatcg cgggctttta cagggaggtg gaggagcaag ggtataaagt ttcttttgaa     2760

tccgcgagca agaaggaagt cgacaagctc gtcgaggagg gcaagctcta catgttccaa     2820

atttataaca aggacttttc cgacaagagc catgggaccc caaacctcca caccatgtac     2880

ttcaaactgc tctttgacga gaacaaccac gggcaaatca ggctgagcgg cggcgccgaa     2940

ttattcatgc gcagggcctc cctcaagaag gaagagctgg tcgtccatcc agccaattcc     3000

ccgatcgcga acaagaaccc ggacaatccg aaaaagacca ccaccctgtc ctacgacgtc     3060

tacaaggaca aacgcttcag cgaagaccag tacgaattac acatcccaat tgcgattaat     3120

aagtgcccaa agaatatctt caaaattaat acagaggtca gggtgctgct caaacacgac     3180

gacaatccgt atgtcatcgg cattgacagg ggcgagcgca atctgctcta tatcgtggtc     3240

gtggatggga agggcaatat tgtggagcag tactccctga acgagattat caacaacttc     3300

aatgggatta ggattaagac cgactatcac agcctgctcg acaagaaaga aaaagagagg     3360

tttgaggccc gccaaaactg gacctccatt gagaatatca aagaattaaa ggccggctat     3420

atttcccaag tcgtccacaa gatctgcgag ctggtggaga aatatgacgc cgtgattgcg     3480

ctcgaagact taaattctgg gttcaagaac tcccgcgtga aggtggaaaa acaggtgtat     3540

cagaaattcg agaaaatgct gatcgacaaa ctcaattata tggtggataa gaagtccaac     3600

ccgtgtgcca cagggggcgc gctgaagggc tatcagatca ccaacaagtt cgagagcttc     3660

aagagcatga gcacccagaa cgggtttatt ttctacatcc cggcgtggct cacctccaag     3720

attgacccga gcaccggctt cgtgaacctc ctgaagacaa agtatacctc cattgccgac     3780

agcaagaagt ttatctcctc cttcgaccgc attatgtatg tgccggagga ggacctcttc     3840

gagttcgccc tcgactacaa aaacttcagc cgcacagatg cggattacat caagaagtgg     3900

aagctgtact cctacgggaa caggatccgc atcttcagga atccaaaaaa aaataacgtc     3960

tttgactggg aggaagtgtg cctgacatcc gcctacaagg aactgttcaa taaatacggc     4020

atcaattacc agcagggcga cattcgcgcc ctcctctgtg agcagtccga caaagcgttt     4080

tactccagct tcatggccct catgtccctg atgctccaaa tgaggaatag catcacaggg     4140

cgcaccgacg tcgacttcct catcagcccg gtgaagaact ccgacgggat cttttacgac     4200

tcccgcaact atgaggcgca agagaatgcg atcctcccga agaacgccga tgcgaacggg     4260

gcctataata tcgccaggaa agtgctctgg gccatcgggc agttcaaaaa ggcggaggat     4320

gagaagctcg acaaggtgaa aattgccatt tccaacaagg agtggctgga gtacgcgcag     4380

acctccgtga agcactctgg cggctcaaaa agaaccgccg acggcagcga attcgagccc     4440

aagaagaaga ggaaagtcgg aagcggagct actaacttca gcctgctgaa gcaggctgga     4500

gacgtggagg agaaccctgg acctatggtg agcaagggcg aggagctgtt caccggggtg     4560

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc     4620

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc     4680

aagctgcccg tgccctggcc caccctcgtg accaccctga cctatggagt gcagtgcttc     4740

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc     4800

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag     4860

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag     4920

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat     4980

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc     5040

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     5100

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     5160

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     5220

ggcatggacg agctgtacaa gtctggtggt tctcccaaga agaagaggaa agtctaaccg     5280

gtcatcatca ccatcaccat tgagtttaaa cccgctgatc agcctcgact gtgccttcta     5340

gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca     5400

ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc     5460

attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagacaata     5520

gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga accagctggg     5580

gctcgatacc gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg     5640

tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta     5700

aagcctaggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg     5760

ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga     5820

gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg     5880

tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag     5940

aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc     6000

gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca     6060

aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt     6120

ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc     6180

tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc     6240

tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc     6300

ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact     6360

tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg     6420

ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta     6480

tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca     6540

aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt acgcgcagaa     6600

aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacact cagtggaacg     6660

aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc acctagatcc     6720

ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa acttggtctg     6780

acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta tttcgttcat     6840

ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc ttaccatctg     6900

gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat ttatcagcaa     6960

taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta tccgcctcca     7020

tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt aatagtttgc     7080

gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt ggtatggctt     7140

cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg ttgtgcaaaa     7200

aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc gcagtgttat     7260

cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc gtaagatgct     7320

tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg cggcgaccga     7380

gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga actttaaaag     7440

tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta ccgctgttga     7500

gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct tttactttca     7560

ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag ggaataaggg     7620

cgacacggaa atgttgaata ctcatactct tcctttttca atattattga agcatttatc     7680

agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat aaacaaatag     7740

gggttccgcg cacatttccc cgaaaagtgc cacctgacgt cgacggatcg ggagatcgat     7800

ctcccgatcc cctagggtcg actctcagta caatctgctc tgatgccgca tagttaagcc     7860

agtatctgct ccctgcttgt gtgttggagg tcgctgagta gtgcgcgagc aaaatttaag     7920

ctacaacaag gcaaggcttg accgacaatt gcatgaagaa tctgcttagg gttaggcgtt     7980

ttgcgctgct tcgcgatgta cgggccagat atacgcgtt                            8019


<210>  89
<211>  10116
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic REDRAW editor

<400>  89
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      420

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      480

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      540

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctggttta gtgaaccgtc      600

agatccgcta gagatccgcg gccgctaata cgactcacta tagggagagc cgccaccatg      660

aaacggacag ccgacggaag cgagttcgag tcaccaaaga agaagcggaa agtcacactt      720

aatattgagg atgaacatag attgcacgag acctctaagg aacctgatgt ttctcttgga      780

tcaacttggt tgtcagattt cccacaagca tgggcagaga ccggaggtat gggtcttgct      840

gttaggcagg caccacttat tattcctttg aaggcaacct ctactcctgt gtcaattaag      900

caatatccaa tgtctcagga agctaggctt ggaattaagc ctcacattca aagacttttg      960

gatcagggta ttttggtgcc atgtcaatca ccttggaaca caccactttt gcctgttaag     1020

aagcctggaa ctaatgatta cagaccagtg caagatttga gggaggttaa caagagagtg     1080

gaagatattc acccaactgt tccaaaccct tataatcttt tgtctggatt gccaccttca     1140

catcaatggt acactgtgct tgatttgaag gatgcatttt tctgccttag gttgcatcca     1200

acatctcagc ctctttttgc tttcgagtgg agagatcctg aaatgggaat ttctggtcaa     1260

cttacatgga ccaggttgcc tcagggtttc aagaactcac caaccttgtt taatgaggca     1320

cttcacaggg atttggctga ttttaggatt caacatcctg atcttatcct tttgcagtat     1380

gttgatgatc ttttgcttgc tgcaacttct gaattggatt gtcaacaggg aactagggca     1440

ttgcttcaaa cacttggaaa tttgggttac agagcttcag caaagaaggc tcagatttgc     1500

caaaagcagg ttaagtatct tggatacttg cttaaggaag gacaaaggtg gttgaccgag     1560

gctagaaagg aaactgtgat gggtcaacca acacctaaga cccctaggca gcttagagag     1620

ttcttgggaa aggcaggttt ttgtaggctt ttcattccag gatttgctga aatggctgca     1680

ccactttatc ctttgaccaa gcctggaact ttgtttaact ggggtccaga tcaacagaag     1740

gcataccaag aaattaagca ggctttgctt actgctccag cacttggttt gcctgatctt     1800

acaaagccat ttgagttgtt cgttgatgaa aagcaaggat atgcaaaggg tgtgcttacc     1860

cagaagttgg gaccttggag aaggcctgtt gcttaccttt ctaagaaact tgatccagtg     1920

gctgcaggtt ggccaccttg tcttagaatg gttgctgcaa ttgcagtgct tacaaaggat     1980

gctggaaagt tgactatggg acaacctctt gttattttgg caccacacgc tgttgaggca     2040

cttgtgaagc agccacctga taggtggttg tcaaacgcaa gaatgaccca ttatcaagct     2100

cttcttttgg atactgatag ggtgcagttc ggtcctgttg tggctttgaa tccagcaaca     2160

cttttgccac ttcctgagga aggattgcaa cacaactgcc ttgatatttt ggctgaggca     2220

catggtacaa gacctgatct taccgatcag ccattgcctg atgctgatca cacttggtac     2280

acagatggat cttcactttt gcaagaagga cagaggaagg ctggtgctgc agttactaca     2340

gagactgaag tgatttgggc taaggcactt ccagctggaa catctgctca aagagcagag     2400

cttattgctt tgacccaggc acttaagatg gctgaaggaa agaagttgaa cgtttacact     2460

gattctaggt atgctttcgc aacagctcat attcacggag aaatctatag aaggagagga     2520

tggttgacat cagagggaaa ggaaattaag aacaaggatg aaattcttgc acttttgaag     2580

gctctttttc ttcctaagag attgtctatt attcattgcc caggacacca aaagggtcat     2640

tcagcagaag ctaggggaaa tagaatggct gatcaggctg caagaaaggc tgcaattact     2700

gagacacctg atacctctac tcttttgatc gaaaactctt caccaaattc aaggcttatt     2760

aactctggca gcgaaactcc gggcacttcc gagtcagcta ctcctgagtc ttccaagctg     2820

gagaagttta caaactgtta cagcctctcc aaaaccctca ggtttaaagc gatcccggtg     2880

ggcaagaccc aggagaacat cgacaacaag aggctcctgg tggaagacga gaagcgcgcc     2940

gaagactaca agggcgtgaa gaagctgctc gataggtact acctcagctt tattaacgac     3000

gtgctgcaca gcatcaaact caagaatctc aacaactaca tctccctctt ccgcaaaaag     3060

acccgcaccg agaaggagaa caaggagctg gagaacctgg agatcaacct ccgcaaggaa     3120

atcgccaaag cgttcaaggg caatgaaggg tacaagagcc tcttcaagaa agacatcatc     3180

gaaactatcc tcccagagtt tctcgatgac aaggacgaga tcgcgctggt gaactccttt     3240

aacgggttca caaccgcgtt taccggcttc tttgataaca gggaaaatat gttctccgag     3300

gaggccaagt ccaccagcat cgccttcagg tgtatcaacg agaacctcac ccgctacatt     3360

tccaatatgg acattttcga gaaggtggat gcgatcttcg ataagcacga ggtgcaggag     3420

atcaaagaga agattctcaa ttccgattat gacgtcgagg atttcttcga aggggagttc     3480

tttaattttg tgctcacaca agagggcatt gacgtgtaca acgcgattat cgggggcttc     3540

gtcacagagt ccggggagaa gattaagggg ctgaatgagt acatcaatct gtacaatcag     3600

aagaccaagc agaaactgcc gaaattcaag ccgctctaca agcaagtcct gtccgatagg     3660

gaaagcctct ccttctacgg cgagggctat accagcgacg aggaggtgct ggaagtcttc     3720

cgcaacacac tgaataagaa tagcgagatt ttctcctcca tcaagaagct cgagaagctc     3780

tttaagaact ttgacgagta cagctccgcc gggattttcg tgaagaacgg gccggcgatc     3840

agcaccatct ccaaggacat ctttggcgag tggaacgtca tcagggacaa gtggaacgcc     3900

gagtacgacg acatccacct gaagaagaag gcggtggtga ccgagaagta tgaggacgat     3960

cgcaggaagt ccttcaaaaa aatcggctcc ttcagcctcg aacagctcca ggagtatgcc     4020

gatgcggatc tgtccgtcgt cgagaagctg aaggaaatca tcattcagaa ggtcgacgag     4080

atctataaag tgtacgggtc cagcgagaag ctgttcgacg ccgactttgt gctcgagaag     4140

tccctcaaaa agaatgacgc cgtggtggcc attatgaaag acctgctcga ctccgtgaag     4200

tccttcgaaa attacattaa agcgttcttt ggggagggga aggaaactaa cagggatgag     4260

tccttctatg gcgactttgt cctcgcgtac gacatcctgc tgaaggtcga ccacatttac     4320

gacgcgatcc gcaactacgt gacacagaag ccgtactcca aagacaagtt caagctgtac     4380

ttccagaacc cgcaatttat ggggggctgg gacaaggata aagagacaga ctaccgcgcg     4440

acaattctcc gctatggctc caaatactat ctggccatca tggacaagaa gtacgcgaag     4500

tgcctgcaga agatcgacaa agacgacgtc aatggcaact atgaaaagat caactacaag     4560

ctgctgccgg gcccgaacaa gatgctcccg aaggtgttct tcagcaagaa gtggatggcc     4620

tactacaatc caagcgagga tattcagaaa atctataaaa acgggacctt caagaagggg     4680

gacatgttta acctcaacga ctgccacaag ctcattgatt tcttcaagga tagcatttcc     4740

cgctacccga aatggtccaa tgcgtacgat tttaacttct ccgagacaga aaagtacaaa     4800

gacatcgcgg gcttttacag ggaggtggag gagcaagggt ataaagtttc ttttgaatcc     4860

gcgagcaaga aggaagtcga caagctcgtc gaggagggca agctctacat gttccaaatt     4920

tataacaagg acttttccga caagagccat gggaccccaa acctccacac catgtacttc     4980

aaactgctct ttgacgagaa caaccacggg caaatcaggc tgagcggcgg cgccgaatta     5040

ttcatgcgca gggcctccct caagaaggaa gagctggtcg tccatccagc caattccccg     5100

atcgcgaaca agaacccgga caatccgaaa aagaccacca ccctgtccta cgacgtctac     5160

aaggacaaac gcttcagcga agaccagtac gaattacaca tcccaattgc gattaataag     5220

tgcccaaaga atatcttcaa aattaataca gaggtcaggg tgctgctcaa acacgacgac     5280

aatccgtatg tcatcggcat tgacaggggc gagcgcaatc tgctctatat cgtggtcgtg     5340

gatgggaagg gcaatattgt ggagcagtac tccctgaacg agattatcaa caacttcaat     5400

gggattagga ttaagaccga ctatcacagc ctgctcgaca agaaagaaaa agagaggttt     5460

gaggcccgcc aaaactggac ctccattgag aatatcaaag aattaaaggc cggctatatt     5520

tcccaagtcg tccacaagat ctgcgagctg gtggagaaat atgacgccgt gattgcgctc     5580

gaagacttaa attctgggtt caagaactcc cgcgtgaagg tggaaaaaca ggtgtatcag     5640

aaattcgaga aaatgctgat cgacaaactc aattatatgg tggataagaa gtccaacccg     5700

tgtgccacag ggggcgcgct gaagggctat cagatcacca acaagttcga gagcttcaag     5760

agcatgagca cccagaacgg gtttattttc tacatcccgg cgtggctcac ctccaagatt     5820

gacccgagca ccggcttcgt gaacctcctg aagacaaagt atacctccat tgccgacagc     5880

aagaagttta tctcctcctt cgaccgcatt atgtatgtgc cggaggagga cctcttcgag     5940

ttcgccctcg actacaaaaa cttcagccgc acagatgcgg attacatcaa gaagtggaag     6000

ctgtactcct acgggaacag gatccgcatc ttcaggaatc caaaaaaaaa taacgtcttt     6060

gactgggagg aagtgtgcct gacatccgcc tacaaggaac tgttcaataa atacggcatc     6120

aattaccagc agggcgacat tcgcgccctc ctctgtgagc agtccgacaa agcgttttac     6180

tccagcttca tggccctcat gtccctgatg ctccaaatgg cgaatagcat cacagggcgc     6240

accgacgtcg acttcctcat cagcccggtg aagaactccg acgggatctt ttacgactcc     6300

cgcaactatg aggcgcaaga gaatgcgatc ctcccgaaga acgccgatgc gaacggggcc     6360

tataatatcg ccaggaaagt gctctgggcc atcgggcagt tcaaaaaggc ggaggatgag     6420

aagctcgaca aggtgaaaat tgccatttcc aacaaggagt ggctggagta cgcgcagacc     6480

tccgtgaagc actctggcgg ctcaaaaaga accgccgacg gcagcgaatt cgagcccaag     6540

aagaagagga aagtcggaag cggagctact aacttcagcc tgctgaagca ggctggagac     6600

gtggaggaga accctggacc tatggtgagc aagggcgagg agctgttcac cggggtggtg     6660

cccatcctgg tcgagctgga cggcgacgta aacggccaca agttcagcgt gtccggcgag     6720

ggcgagggcg atgccaccta cggcaagctg accctgaagt tcatctgcac caccggcaag     6780

ctgcccgtgc cctggcccac cctcgtgacc accctgacct atggagtgca gtgcttcagc     6840

cgctaccccg accacatgaa gcagcacgac ttcttcaagt ccgccatgcc cgaaggctac     6900

gtccaggagc gcaccatctt cttcaaggac gacggcaact acaagacccg cgccgaggtg     6960

aagttcgagg gcgacaccct ggtgaaccgc atcgagctga agggcatcga cttcaaggag     7020

gacggcaaca tcctggggca caagctggag tacaactaca acagccacaa cgtctatatc     7080

atggccgaca agcagaagaa cggcatcaag gtgaacttca agatccgcca caacatcgag     7140

gacggcagcg tgcagctcgc cgaccactac cagcagaaca cccccatcgg cgacggcccc     7200

gtgctgctgc ccgacaacca ctacctgagc acccagtccg ccctgagcaa agaccccaac     7260

gagaagcgcg atcacatggt cctgctggag ttcgtgaccg ccgccgggat cactctcggc     7320

atggacgagc tgtacaagtc tggtggttct cccaagaaga agaggaaagt ctaaccggtc     7380

atcatcacca tcaccattga gtttaaaccc gctgatcagc ctcgactgtg ccttctagtt     7440

gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa ggtgccactc     7500

ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt     7560

ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa gacaatagca     7620

ggcatgctgg ggatgcggtg ggctctatgg cttctgaggc ggaaagaacc agctggggct     7680

cgataccgtc gacctctagc tagagcttgg cgtaatcatg gtcatagctg tttcctgtgt     7740

gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata aagtgtaaag     7800

cctagggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca ctgcccgctt     7860

tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc gcggggagag     7920

gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg cgctcggtcg     7980

ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta tccacagaat     8040

caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     8100

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     8160

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     8220

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     8280

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     8340

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     8400

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     8460

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     8520

cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct     8580

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     8640

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     8700

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacactcag tggaacgaaa     8760

actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt     8820

taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca     8880

gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca     8940

tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc     9000

ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa     9060

accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc     9120

agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca     9180

acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat     9240

tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag     9300

cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac     9360

tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt     9420

ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt     9480

gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc     9540

tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat     9600

ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca     9660

gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga     9720

cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg     9780

gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg     9840

ttccgcgcac atttccccga aaagtgccac ctgacgtcga cggatcggga gatcgatctc     9900

ccgatcccct agggtcgact ctcagtacaa tctgctctga tgccgcatag ttaagccagt     9960

atctgctccc tgcttgtgtg ttggaggtcg ctgagtagtg cgcgagcaaa atttaagcta    10020

caacaaggca aggcttgacc gacaattgca tgaagaatct gcttagggtt aggcgttttg    10080

cgctgcttcg cgatgtacgg gccagatata cgcgtt                              10116


<210>  90
<211>  6717
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic tagRNA

<400>  90
atgaaacgga cagccgacgg aagcgagttc gagtcaccaa agaagaagcg gaaagtcaca       60

cttaatattg aggatgaaca tagattgcac gagacctcta aggaacctga tgtttctctt      120

ggatcaactt ggttgtcaga tttcccacaa gcatgggcag agaccggagg tatgggtctt      180

gctgttaggc aggcaccact tattattcct ttgaaggcaa cctctactcc tgtgtcaatt      240

aagcaatatc caatgtctca ggaagctagg cttggaatta agcctcacat tcaaagactt      300

ttggatcagg gtattttggt gccatgtcaa tcaccttgga acacaccact tttgcctgtt      360

aagaagcctg gaactaatga ttacagacca gtgcaagatt tgagggaggt taacaagaga      420

gtggaagata ttcacccaac tgttccaaac ccttataatc ttttgtctgg attgccacct      480

tcacatcaat ggtacactgt gcttgatttg aaggatgcat ttttctgcct taggttgcat      540

ccaacatctc agcctctttt tgctttcgag tggagagatc ctgaaatggg aatttctggt      600

caacttacat ggaccaggtt gcctcagggt ttcaagaact caccaacctt gtttaatgag      660

gcacttcaca gggatttggc tgattttagg attcaacatc ctgatcttat ccttttgcag      720

tatgttgatg atcttttgct tgctgcaact tctgaattgg attgtcaaca gggaactagg      780

gcattgcttc aaacacttgg aaatttgggt tacagagctt cagcaaagaa ggctcagatt      840

tgccaaaagc aggttaagta tcttggatac ttgcttaagg aaggacaaag gtggttgacc      900

gaggctagaa aggaaactgt gatgggtcaa ccaacaccta agacccctag gcagcttaga      960

gagttcttgg gaaaggcagg tttttgtagg cttttcattc caggatttgc tgaaatggct     1020

gcaccacttt atcctttgac caagcctgga actttgttta actggggtcc agatcaacag     1080

aaggcatacc aagaaattaa gcaggctttg cttactgctc cagcacttgg tttgcctgat     1140

cttacaaagc catttgagtt gttcgttgat gaaaagcaag gatatgcaaa gggtgtgctt     1200

acccagaagt tgggaccttg gagaaggcct gttgcttacc tttctaagaa acttgatcca     1260

gtggctgcag gttggccacc ttgtcttaga atggttgctg caattgcagt gcttacaaag     1320

gatgctggaa agttgactat gggacaacct cttgttattt tggcaccaca cgctgttgag     1380

gcacttgtga agcagccacc tgataggtgg ttgtcaaacg caagaatgac ccattatcaa     1440

gctcttcttt tggatactga tagggtgcag ttcggtcctg ttgtggcttt gaatccagca     1500

acacttttgc cacttcctga ggaaggattg caacacaact gccttgatat tttggctgag     1560

gcacatggta caagacctga tcttaccgat cagccattgc ctgatgctga tcacacttgg     1620

tacacagatg gatcttcact tttgcaagaa ggacagagga aggctggtgc tgcagttact     1680

acagagactg aagtgatttg ggctaaggca cttccagctg gaacatctgc tcaaagagca     1740

gagcttattg ctttgaccca ggcacttaag atggctgaag gaaagaagtt gaacgtttac     1800

actgattcta ggtatgcttt cgcaacagct catattcacg gagaaatcta tagaaggaga     1860

ggatggttga catcagaggg aaaggaaatt aagaacaagg atgaaattct tgcacttttg     1920

aaggctcttt ttcttcctaa gagattgtct attattcatt gcccaggaca ccaaaagggt     1980

cattcagcag aagctagggg aaatagaatg gctgatcagg ctgcaagaaa ggctgcaatt     2040

actgagacac ctgatacctc tactcttttg atcgaaaact cttcaccaaa ttcaaggctt     2100

attaactctg gcagcgaaac tccgggcact tccgagtcag ctactcctga gtcttccaag     2160

ctggagaagt ttacaaactg ttacagcctc tccaaaaccc tcaggtttaa agcgatcccg     2220

gtgggcaaga cccaggagaa catcgacaac aagaggctcc tggtggaaga cgagaagcgc     2280

gccgaagact acaagggcgt gaagaagctg ctcgataggt actacctcag ctttattaac     2340

gacgtgctgc acagcatcaa actcaagaat ctcaacaact acatctccct cttccgcaaa     2400

aagacccgca ccgagaagga gaacaaggag ctggagaacc tggagatcaa cctccgcaag     2460

gaaatcgcca aagcgttcaa gggcaatgaa gggtacaaga gcctcttcaa gaaagacatc     2520

atcgaaacta tcctcccaga gtttctcgat gacaaggacg agatcgcgct ggtgaactcc     2580

tttaacgggt tcacaaccgc gtttaccggc ttctttgata acagggaaaa tatgttctcc     2640

gaggaggcca agtccaccag catcgccttc aggtgtatca acgagaacct cacccgctac     2700

atttccaata tggacatttt cgagaaggtg gatgcgatct tcgataagca cgaggtgcag     2760

gagatcaaag agaagattct caattccgat tatgacgtcg aggatttctt cgaaggggag     2820

ttctttaatt ttgtgctcac acaagagggc attgacgtgt acaacgcgat tatcgggggc     2880

ttcgtcacag agtccgggga gaagattaag gggctgaatg agtacatcaa tctgtacaat     2940

cagaagacca agcagaaact gccgaaattc aagccgctct acaagcaagt cctgtccgat     3000

agggaaagcc tctccttcta cggcgagggc tataccagcg acgaggaggt gctggaagtc     3060

ttccgcaaca cactgaataa gaatagcgag attttctcct ccatcaagaa gctcgagaag     3120

ctctttaaga actttgacga gtacagctcc gccgggattt tcgtgaagaa cgggccggcg     3180

atcagcacca tctccaagga catctttggc gagtggaacg tcatcaggga caagtggaac     3240

gccgagtacg acgacatcca cctgaagaag aaggcggtgg tgaccgagaa gtatgaggac     3300

gatcgcagga agtccttcaa aaaaatcggc tccttcagcc tcgaacagct ccaggagtat     3360

gccgatgcgg atctgtccgt cgtcgagaag ctgaaggaaa tcatcattca gaaggtcgac     3420

gagatctata aagtgtacgg gtccagcgag aagctgttcg acgccgactt tgtgctcgag     3480

aagtccctca aaaagaatga cgccgtggtg gccattatga aagacctgct cgactccgtg     3540

aagtccttcg aaaattacat taaagcgttc tttggggagg ggaaggaaac taacagggat     3600

gagtccttct atggcgactt tgtcctcgcg tacgacatcc tgctgaaggt cgaccacatt     3660

tacgacgcga tccgcaacta cgtgacacag aagccgtact ccaaagacaa gttcaagctg     3720

tacttccaga acccgcaatt tatggggggc tgggacaagg ataaagagac agactaccgc     3780

gcgacaattc tccgctatgg ctccaaatac tatctggcca tcatggacaa gaagtacgcg     3840

aagtgcctgc agaagatcga caaagacgac gtcaatggca actatgaaaa gatcaactac     3900

aagctgctgc cgggcccgaa caagatgctc ccgaaggtgt tcttcagcaa gaagtggatg     3960

gcctactaca atccaagcga ggatattcag aaaatctata aaaacgggac cttcaagaag     4020

ggggacatgt ttaacctcaa cgactgccac aagctcattg atttcttcaa ggatagcatt     4080

tcccgctacc cgaaatggtc caatgcgtac gattttaact tctccgagac agaaaagtac     4140

aaagacatcg cgggctttta cagggaggtg gaggagcaag ggtataaagt ttcttttgaa     4200

tccgcgagca agaaggaagt cgacaagctc gtcgaggagg gcaagctcta catgttccaa     4260

atttataaca aggacttttc cgacaagagc catgggaccc caaacctcca caccatgtac     4320

ttcaaactgc tctttgacga gaacaaccac gggcaaatca ggctgagcgg cggcgccgaa     4380

ttattcatgc gcagggcctc cctcaagaag gaagagctgg tcgtccatcc agccaattcc     4440

ccgatcgcga acaagaaccc ggacaatccg aaaaagacca ccaccctgtc ctacgacgtc     4500

tacaaggaca aacgcttcag cgaagaccag tacgaattac acatcccaat tgcgattaat     4560

aagtgcccaa agaatatctt caaaattaat acagaggtca gggtgctgct caaacacgac     4620

gacaatccgt atgtcatcgg cattgacagg ggcgagcgca atctgctcta tatcgtggtc     4680

gtggatggga agggcaatat tgtggagcag tactccctga acgagattat caacaacttc     4740

aatgggatta ggattaagac cgactatcac agcctgctcg acaagaaaga aaaagagagg     4800

tttgaggccc gccaaaactg gacctccatt gagaatatca aagaattaaa ggccggctat     4860

atttcccaag tcgtccacaa gatctgcgag ctggtggaga aatatgacgc cgtgattgcg     4920

ctcgaagact taaattctgg gttcaagaac tcccgcgtga aggtggaaaa acaggtgtat     4980

cagaaattcg agaaaatgct gatcgacaaa ctcaattata tggtggataa gaagtccaac     5040

ccgtgtgcca cagggggcgc gctgaagggc tatcagatca ccaacaagtt cgagagcttc     5100

aagagcatga gcacccagaa cgggtttatt ttctacatcc cggcgtggct cacctccaag     5160

attgacccga gcaccggctt cgtgaacctc ctgaagacaa agtatacctc cattgccgac     5220

agcaagaagt ttatctcctc cttcgaccgc attatgtatg tgccggagga ggacctcttc     5280

gagttcgccc tcgactacaa aaacttcagc cgcacagatg cggattacat caagaagtgg     5340

aagctgtact cctacgggaa caggatccgc atcttcagga atccaaaaaa aaataacgtc     5400

tttgactggg aggaagtgtg cctgacatcc gcctacaagg aactgttcaa taaatacggc     5460

atcaattacc agcagggcga cattcgcgcc ctcctctgtg agcagtccga caaagcgttt     5520

tactccagct tcatggccct catgtccctg atgctccaaa tggcgaatag catcacaggg     5580

cgcaccgacg tcgacttcct catcagcccg gtgaagaact ccgacgggat cttttacgac     5640

tcccgcaact atgaggcgca agagaatgcg atcctcccga agaacgccga tgcgaacggg     5700

gcctataata tcgccaggaa agtgctctgg gccatcgggc agttcaaaaa ggcggaggat     5760

gagaagctcg acaaggtgaa aattgccatt tccaacaagg agtggctgga gtacgcgcag     5820

acctccgtga agcactctgg cggctcaaaa agaaccgccg acggcagcga attcgagccc     5880

aagaagaaga ggaaagtcgg aagcggagct actaacttca gcctgctgaa gcaggctgga     5940

gacgtggagg agaaccctgg acctatggtg agcaagggcg aggagctgtt caccggggtg     6000

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc     6060

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc     6120

aagctgcccg tgccctggcc caccctcgtg accaccctga cctatggagt gcagtgcttc     6180

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc     6240

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag     6300

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag     6360

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat     6420

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc     6480

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     6540

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     6600

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     6660

ggcatggacg agctgtacaa gtctggtggt tctcccaaga agaagaggaa agtctaa        6717


<210>  91
<211>  2238
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic editor sequence

<400>  91

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Asn Ser Arg Leu Ile Asn Ser Gly 
    690                 695                 700                 


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Lys 
705                 710                 715                 720 


Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe 
                725                 730                 735     


Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg 
            740                 745                 750         


Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys 
        755                 760                 765             


Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His 
    770                 775                 780                 


Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys 
785                 790                 795                 800 


Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile 
                805                 810                 815     


Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr 
            820                 825                 830         


Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe 
        835                 840                 845             


Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe 
    850                 855                 860                 


Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser 
865                 870                 875                 880 


Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn 
                885                 890                 895     


Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala 
            900                 905                 910         


Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn 
        915                 920                 925             


Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe 
    930                 935                 940                 


Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly Gly 
945                 950                 955                 960 


Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr Ile 
                965                 970                 975     


Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys Pro 
            980                 985                 990         


Leu Tyr Lys Gln Val Leu Ser Asp  Arg Glu Ser Leu Ser  Phe Tyr Gly 
        995                 1000                 1005             


Glu Gly  Tyr Thr Ser Asp Glu  Glu Val Leu Glu Val  Phe Arg Asn 
    1010                 1015                 1020             


Thr Leu  Asn Lys Asn Ser Glu  Ile Phe Ser Ser Ile  Lys Lys Leu 
    1025                 1030                 1035             


Glu Lys  Leu Phe Lys Asn Phe  Asp Glu Tyr Ser Ser  Ala Gly Ile 
    1040                 1045                 1050             


Phe Val  Lys Asn Gly Pro Ala  Ile Ser Thr Ile Ser  Lys Asp Ile 
    1055                 1060                 1065             


Phe Gly  Glu Trp Asn Val Ile  Arg Asp Lys Trp Asn  Ala Glu Tyr 
    1070                 1075                 1080             


Asp Asp  Ile His Leu Lys Lys  Lys Ala Val Val Thr  Glu Lys Tyr 
    1085                 1090                 1095             


Glu Asp  Asp Arg Arg Lys Ser  Phe Lys Lys Ile Gly  Ser Phe Ser 
    1100                 1105                 1110             


Leu Glu  Gln Leu Gln Glu Tyr  Ala Asp Ala Asp Leu  Ser Val Val 
    1115                 1120                 1125             


Glu Lys  Leu Lys Glu Ile Ile  Ile Gln Lys Val Asp  Glu Ile Tyr 
    1130                 1135                 1140             


Lys Val  Tyr Gly Ser Ser Glu  Lys Leu Phe Asp Ala  Asp Phe Val 
    1145                 1150                 1155             


Leu Glu  Lys Ser Leu Lys Lys  Asn Asp Ala Val Val  Ala Ile Met 
    1160                 1165                 1170             


Lys Asp  Leu Leu Asp Ser Val  Lys Ser Phe Glu Asn  Tyr Ile Lys 
    1175                 1180                 1185             


Ala Phe  Phe Gly Glu Gly Lys  Glu Thr Asn Arg Asp  Glu Ser Phe 
    1190                 1195                 1200             


Tyr Gly  Asp Phe Val Leu Ala  Tyr Asp Ile Leu Leu  Lys Val Asp 
    1205                 1210                 1215             


His Ile  Tyr Asp Ala Ile Arg  Asn Tyr Val Thr Gln  Lys Pro Tyr 
    1220                 1225                 1230             


Ser Lys  Asp Lys Phe Lys Leu  Tyr Phe Gln Asn Pro  Gln Phe Met 
    1235                 1240                 1245             


Gly Gly  Trp Asp Lys Asp Lys  Glu Thr Asp Tyr Arg  Ala Thr Ile 
    1250                 1255                 1260             


Leu Arg  Tyr Gly Ser Lys Tyr  Tyr Leu Ala Ile Met  Asp Lys Lys 
    1265                 1270                 1275             


Tyr Ala  Lys Cys Leu Gln Lys  Ile Asp Lys Asp Asp  Val Asn Gly 
    1280                 1285                 1290             


Asn Tyr  Glu Lys Ile Asn Tyr  Lys Leu Leu Pro Gly  Pro Asn Lys 
    1295                 1300                 1305             


Met Leu  Pro Lys Val Phe Phe  Ser Lys Lys Trp Met  Ala Tyr Tyr 
    1310                 1315                 1320             


Asn Pro  Ser Glu Asp Ile Gln  Lys Ile Tyr Lys Asn  Gly Thr Phe 
    1325                 1330                 1335             


Lys Lys  Gly Asp Met Phe Asn  Leu Asn Asp Cys His  Lys Leu Ile 
    1340                 1345                 1350             


Asp Phe  Phe Lys Asp Ser Ile  Ser Arg Tyr Pro Lys  Trp Ser Asn 
    1355                 1360                 1365             


Ala Tyr  Asp Phe Asn Phe Ser  Glu Thr Glu Lys Tyr  Lys Asp Ile 
    1370                 1375                 1380             


Ala Gly  Phe Tyr Arg Glu Val  Glu Glu Gln Gly Tyr  Lys Val Ser 
    1385                 1390                 1395             


Phe Glu  Ser Ala Ser Lys Lys  Glu Val Asp Lys Leu  Val Glu Glu 
    1400                 1405                 1410             


Gly Lys  Leu Tyr Met Phe Gln  Ile Tyr Asn Lys Asp  Phe Ser Asp 
    1415                 1420                 1425             


Lys Ser  His Gly Thr Pro Asn  Leu His Thr Met Tyr  Phe Lys Leu 
    1430                 1435                 1440             


Leu Phe  Asp Glu Asn Asn His  Gly Gln Ile Arg Leu  Ser Gly Gly 
    1445                 1450                 1455             


Ala Glu  Leu Phe Met Arg Arg  Ala Ser Leu Lys Lys  Glu Glu Leu 
    1460                 1465                 1470             


Val Val  His Pro Ala Asn Ser  Pro Ile Ala Asn Lys  Asn Pro Asp 
    1475                 1480                 1485             


Asn Pro  Lys Lys Thr Thr Thr  Leu Ser Tyr Asp Val  Tyr Lys Asp 
    1490                 1495                 1500             


Lys Arg  Phe Ser Glu Asp Gln  Tyr Glu Leu His Ile  Pro Ile Ala 
    1505                 1510                 1515             


Ile Asn  Lys Cys Pro Lys Asn  Ile Phe Lys Ile Asn  Thr Glu Val 
    1520                 1525                 1530             


Arg Val  Leu Leu Lys His Asp  Asp Asn Pro Tyr Val  Ile Gly Ile 
    1535                 1540                 1545             


Asp Arg  Gly Glu Arg Asn Leu  Leu Tyr Ile Val Val  Val Asp Gly 
    1550                 1555                 1560             


Lys Gly  Asn Ile Val Glu Gln  Tyr Ser Leu Asn Glu  Ile Ile Asn 
    1565                 1570                 1575             


Asn Phe  Asn Gly Ile Arg Ile  Lys Thr Asp Tyr His  Ser Leu Leu 
    1580                 1585                 1590             


Asp Lys  Lys Glu Lys Glu Arg  Phe Glu Ala Arg Gln  Asn Trp Thr 
    1595                 1600                 1605             


Ser Ile  Glu Asn Ile Lys Glu  Leu Lys Ala Gly Tyr  Ile Ser Gln 
    1610                 1615                 1620             


Val Val  His Lys Ile Cys Glu  Leu Val Glu Lys Tyr  Asp Ala Val 
    1625                 1630                 1635             


Ile Ala  Leu Glu Asp Leu Asn  Ser Gly Phe Lys Asn  Ser Arg Val 
    1640                 1645                 1650             


Lys Val  Glu Lys Gln Val Tyr  Gln Lys Phe Glu Lys  Met Leu Ile 
    1655                 1660                 1665             


Asp Lys  Leu Asn Tyr Met Val  Asp Lys Lys Ser Asn  Pro Cys Ala 
    1670                 1675                 1680             


Thr Gly  Gly Ala Leu Lys Gly  Tyr Gln Ile Thr Asn  Lys Phe Glu 
    1685                 1690                 1695             


Ser Phe  Lys Ser Met Ser Thr  Gln Asn Gly Phe Ile  Phe Tyr Ile 
    1700                 1705                 1710             


Pro Ala  Trp Leu Thr Ser Lys  Ile Asp Pro Ser Thr  Gly Phe Val 
    1715                 1720                 1725             


Asn Leu  Leu Lys Thr Lys Tyr  Thr Ser Ile Ala Asp  Ser Lys Lys 
    1730                 1735                 1740             


Phe Ile  Ser Ser Phe Asp Arg  Ile Met Tyr Val Pro  Glu Glu Asp 
    1745                 1750                 1755             


Leu Phe  Glu Phe Ala Leu Asp  Tyr Lys Asn Phe Ser  Arg Thr Asp 
    1760                 1765                 1770             


Ala Asp  Tyr Ile Lys Lys Trp  Lys Leu Tyr Ser Tyr  Gly Asn Arg 
    1775                 1780                 1785             


Ile Arg  Ile Phe Arg Asn Pro  Lys Lys Asn Asn Val  Phe Asp Trp 
    1790                 1795                 1800             


Glu Glu  Val Cys Leu Thr Ser  Ala Tyr Lys Glu Leu  Phe Asn Lys 
    1805                 1810                 1815             


Tyr Gly  Ile Asn Tyr Gln Gln  Gly Asp Ile Arg Ala  Leu Leu Cys 
    1820                 1825                 1830             


Glu Gln  Ser Asp Lys Ala Phe  Tyr Ser Ser Phe Met  Ala Leu Met 
    1835                 1840                 1845             


Ser Leu  Met Leu Gln Met Ala  Asn Ser Ile Thr Gly  Arg Thr Asp 
    1850                 1855                 1860             


Val Asp  Phe Leu Ile Ser Pro  Val Lys Asn Ser Asp  Gly Ile Phe 
    1865                 1870                 1875             


Tyr Asp  Ser Arg Asn Tyr Glu  Ala Gln Glu Asn Ala  Ile Leu Pro 
    1880                 1885                 1890             


Lys Asn  Ala Asp Ala Asn Gly  Ala Tyr Asn Ile Ala  Arg Lys Val 
    1895                 1900                 1905             


Leu Trp  Ala Ile Gly Gln Phe  Lys Lys Ala Glu Asp  Glu Lys Leu 
    1910                 1915                 1920             


Asp Lys  Val Lys Ile Ala Ile  Ser Asn Lys Glu Trp  Leu Glu Tyr 
    1925                 1930                 1935             


Ala Gln  Thr Ser Val Lys His  Ser Gly Gly Ser Lys  Arg Thr Ala 
    1940                 1945                 1950             


Asp Gly  Ser Glu Phe Glu Pro  Lys Lys Lys Arg Lys  Val Gly Ser 
    1955                 1960                 1965             


Gly Ala  Thr Asn Phe Ser Leu  Leu Lys Gln Ala Gly  Asp Val Glu 
    1970                 1975                 1980             


Glu Asn  Pro Gly Pro Met Val  Ser Lys Gly Glu Glu  Leu Phe Thr 
    1985                 1990                 1995             


Gly Val  Val Pro Ile Leu Val  Glu Leu Asp Gly Asp  Val Asn Gly 
    2000                 2005                 2010             


His Lys  Phe Ser Val Ser Gly  Glu Gly Glu Gly Asp  Ala Thr Tyr 
    2015                 2020                 2025             


Gly Lys  Leu Thr Leu Lys Phe  Ile Cys Thr Thr Gly  Lys Leu Pro 
    2030                 2035                 2040             


Val Pro  Trp Pro Thr Leu Val  Thr Thr Leu Thr Tyr  Gly Val Gln 
    2045                 2050                 2055             


Cys Phe  Ser Arg Tyr Pro Asp  His Met Lys Gln His  Asp Phe Phe 
    2060                 2065                 2070             


Lys Ser  Ala Met Pro Glu Gly  Tyr Val Gln Glu Arg  Thr Ile Phe 
    2075                 2080                 2085             


Phe Lys  Asp Asp Gly Asn Tyr  Lys Thr Arg Ala Glu  Val Lys Phe 
    2090                 2095                 2100             


Glu Gly  Asp Thr Leu Val Asn  Arg Ile Glu Leu Lys  Gly Ile Asp 
    2105                 2110                 2115             


Phe Lys  Glu Asp Gly Asn Ile  Leu Gly His Lys Leu  Glu Tyr Asn 
    2120                 2125                 2130             


Tyr Asn  Ser His Asn Val Tyr  Ile Met Ala Asp Lys  Gln Lys Asn 
    2135                 2140                 2145             


Gly Ile  Lys Val Asn Phe Lys  Ile Arg His Asn Ile  Glu Asp Gly 
    2150                 2155                 2160             


Ser Val  Gln Leu Ala Asp His  Tyr Gln Gln Asn Thr  Pro Ile Gly 
    2165                 2170                 2175             


Asp Gly  Pro Val Leu Leu Pro  Asp Asn His Tyr Leu  Ser Thr Gln 
    2180                 2185                 2190             


Ser Ala  Leu Ser Lys Asp Pro  Asn Glu Lys Arg Asp  His Met Val 
    2195                 2200                 2205             


Leu Leu  Glu Phe Val Thr Ala  Ala Gly Ile Thr Leu  Gly Met Asp 
    2210                 2215                 2220             


Glu Leu  Tyr Lys Ser Gly Gly  Ser Pro Lys Lys Lys  Arg Lys Val 
    2225                 2230                 2235             


<210>  92
<211>  231
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic tagRNA

<400>  92
tatttctata agtgtagatt actcgtgtat atatactccg caccgaggtt ggtacgaaca       60

ccgggagtct ttaacacgac cgccacggat caggatcacg gagtgctcct gcaggttgtg      120

accttcacca ccgatgtagg aagtcacttc gaaaccgtta gtcagacgaa cacggcatac      180

tttacgcagc gcggagttcg gtttacgagg agtggtagta tatacacgag t               231


<210>  93
<211>  218
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic tagRNA

<400>  93
taatttctac taagtgtaga ttacggctcc gcagtggatg gcggtaagtc tccatagaat       60

ggaggacagc gcggagaatc tcgctctctc caggggaagc cgaagtttcc aaaaggtcgt      120

tgatcaaagc gcggcgcgtt gtttcatcaa ggcgtacggt caccgtaacc agcaaatcaa      180

tatcactgtg tggcttcagg ccgccatcca ctgcggat                              218


<210>  94
<211>  213
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic tagRNA

<400>  94
taatttcaac taagtgtaga ttacggctcc gcagtggatg gcggtaagtc tccatagaat       60

ggagggcgga gaatctcgct ctctccaggg gaagccgaag tttccaaaag gtcgttgatc      120

aaagcgcggc gcgttgtttc atcaaggcgt acggtcaccg taaccagcaa atcaatatca      180

ctgtgtggct tcaggccgcc atccactgcg gat                                   213


<210>  95
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic decoy hairpin

<400>  95
taagtctcca tagaatggag g                                                 21


<210>  96
<211>  1267
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic LbCas12a polypeptide

<400>  96

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser 
            20                  25                  30          


Lys Thr Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn 
        35                  40                  45              


Ile Asp Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp 
    50                  55                  60                  


Tyr Lys Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile 
65                  70                  75                  80  


Asn Asp Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile 
                85                  90                  95      


Ser Leu Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu 
            100                 105                 110         


Glu Asn Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys 
        115                 120                 125             


Gly Asn Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr 
    130                 135                 140                 


Ile Leu Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn 
145                 150                 155                 160 


Ser Phe Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg 
                165                 170                 175     


Glu Asn Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg 
            180                 185                 190         


Cys Ile Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe 
        195                 200                 205             


Glu Lys Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys 
    210                 215                 220                 


Glu Lys Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly 
225                 230                 235                 240 


Glu Phe Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn 
                245                 250                 255     


Ala Ile Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly 
            260                 265                 270         


Leu Asn Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu 
        275                 280                 285             


Pro Lys Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser 
    290                 295                 300                 


Leu Ser Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu 
305                 310                 315                 320 


Val Phe Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile 
                325                 330                 335     


Lys Lys Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala 
            340                 345                 350         


Gly Ile Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp 
        355                 360                 365             


Ile Phe Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr 
    370                 375                 380                 


Asp Asp Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu 
385                 390                 395                 400 


Asp Asp Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu 
                405                 410                 415     


Gln Leu Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu 
            420                 425                 430         


Lys Glu Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly 
        435                 440                 445             


Ser Ser Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu 
    450                 455                 460                 


Lys Lys Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser 
465                 470                 475                 480 


Val Lys Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys 
                485                 490                 495     


Glu Thr Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr 
            500                 505                 510         


Asp Ile Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr 
        515                 520                 525             


Val Thr Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln 
    530                 535                 540                 


Asn Pro Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr 
545                 550                 555                 560 


Arg Ala Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met 
                565                 570                 575     


Asp Lys Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val 
            580                 585                 590         


Asn Gly Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn 
        595                 600                 605             


Lys Met Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr 
    610                 615                 620                 


Asn Pro Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys 
625                 630                 635                 640 


Lys Gly Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe 
                645                 650                 655     


Phe Lys Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp 
            660                 665                 670         


Phe Asn Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr 
        675                 680                 685             


Arg Glu Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser 
    690                 695                 700                 


Lys Lys Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe 
705                 710                 715                 720 


Gln Ile Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn 
                725                 730                 735     


Leu His Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly 
            740                 745                 750         


Gln Ile Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser 
        755                 760                 765             


Leu Lys Lys Glu Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala 
    770                 775                 780                 


Asn Lys Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp 
785                 790                 795                 800 


Val Tyr Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile 
                805                 810                 815     


Pro Ile Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr 
            820                 825                 830         


Glu Val Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly 
        835                 840                 845             


Ile Asp Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly 
    850                 855                 860                 


Lys Gly Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn 
865                 870                 875                 880 


Phe Asn Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys 
                885                 890                 895     


Lys Glu Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu 
            900                 905                 910         


Asn Ile Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys 
        915                 920                 925             


Ile Cys Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp 
    930                 935                 940                 


Leu Asn Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val 
945                 950                 955                 960 


Tyr Gln Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val 
                965                 970                 975     


Asp Lys Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr 
            980                 985                 990         


Gln Ile Thr Asn Lys Phe Glu Ser  Phe Lys Ser Met Ser  Thr Gln Asn 
        995                 1000                 1005             


Gly Phe  Ile Phe Tyr Ile Pro  Ala Trp Leu Thr Ser  Lys Ile Asp 
    1010                 1015                 1020             


Pro Ser  Thr Gly Phe Val Asn  Leu Leu Lys Thr Lys  Tyr Thr Ser 
    1025                 1030                 1035             


Ile Ala  Asp Ser Lys Lys Phe  Ile Ser Ser Phe Asp  Arg Ile Met 
    1040                 1045                 1050             


Tyr Val  Pro Glu Glu Asp Leu  Phe Glu Phe Ala Leu  Asp Tyr Lys 
    1055                 1060                 1065             


Asn Phe  Ser Arg Thr Asp Ala  Asp Tyr Ile Lys Lys  Trp Lys Leu 
    1070                 1075                 1080             


Tyr Ser  Tyr Gly Asn Arg Ile  Arg Ile Phe Arg Asn  Pro Lys Lys 
    1085                 1090                 1095             


Asn Asn  Val Phe Asp Trp Glu  Glu Val Cys Leu Thr  Ser Ala Tyr 
    1100                 1105                 1110             


Lys Glu  Leu Phe Asn Lys Tyr  Gly Ile Asn Tyr Gln  Gln Gly Asp 
    1115                 1120                 1125             


Ile Arg  Ala Leu Leu Cys Glu  Gln Ser Asp Lys Ala  Phe Tyr Ser 
    1130                 1135                 1140             


Ser Phe  Met Ala Leu Met Ser  Leu Met Leu Gln Met  Arg Asn Ser 
    1145                 1150                 1155             


Ile Thr  Gly Arg Thr Asp Val  Asp Phe Leu Ile Ser  Pro Val Lys 
    1160                 1165                 1170             


Asn Ser  Asp Gly Ile Phe Tyr  Asp Ser Arg Asn Tyr  Glu Ala Gln 
    1175                 1180                 1185             


Glu Asn  Ala Ile Leu Pro Lys  Asn Ala Asp Ala Asn  Gly Ala Tyr 
    1190                 1195                 1200             


Asn Ile  Ala Arg Lys Val Leu  Trp Ala Ile Gly Gln  Phe Lys Lys 
    1205                 1210                 1215             


Ala Glu  Asp Glu Lys Leu Asp  Lys Val Lys Ile Ala  Ile Ser Asn 
    1220                 1225                 1230             


Lys Glu  Trp Leu Glu Tyr Ala  Gln Thr Ser Val Lys  His Ser Gly 
    1235                 1240                 1245             


Gly Ser  Lys Arg Thr Ala Asp  Gly Ser Glu Phe Glu  Pro Lys Lys 
    1250                 1255                 1260             


Lys Arg  Lys Val 
    1265         


<210>  97
<211>  717
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic exonuclease

<400>  97

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr 
            20                  25                  30          


Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe 
        35                  40                  45              


Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln 
    50                  55                  60                  


Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile 
65                  70                  75                  80  


Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His 
                85                  90                  95      


Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro 
            100                 105                 110         


Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr 
        115                 120                 125             


Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile 
    130                 135                 140                 


His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro 
145                 150                 155                 160 


Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys 
                165                 170                 175     


Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro 
        195                 200                 205             


Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg 
    210                 215                 220                 


Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln 
225                 230                 235                 240 


Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln 
                245                 250                 255     


Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg 
            260                 265                 270         


Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu 
        275                 280                 285             


Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys 
    290                 295                 300                 


Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg 
305                 310                 315                 320 


Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe 
                325                 330                 335     


Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu 
            340                 345                 350         


Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln 
        355                 360                 365             


Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro 
    370                 375                 380                 


Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu 
385                 390                 395                 400 


Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys 
                405                 410                 415     


Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val 
            420                 425                 430         


Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly 
        435                 440                 445             


Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys 
    450                 455                 460                 


Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln 
465                 470                 475                 480 


Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala 
                485                 490                 495     


Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His 
            500                 505                 510         


Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu 
        515                 520                 525             


Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly 
    530                 535                 540                 


Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr 
545                 550                 555                 560 


Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser 
                565                 570                 575     


Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala 
            580                 585                 590         


Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala 
        595                 600                 605             


Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr 
    610                 615                 620                 


Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu 
625                 630                 635                 640 


Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly 
                645                 650                 655     


His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp 
            660                 665                 670         


Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr 
        675                 680                 685             


Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Lys Arg Thr Ala 
    690                 695                 700                 


Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
705                 710                 715         


<210>  98
<211>  343
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic exonuclease

<400>  98

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Glu His Pro His Asn Glu Asn Ala Gly Ser Asp Pro His 
            20                  25                  30          


Arg Asp Cys Ser Asp Glu Thr Gly Glu Val Ala Asp Pro Val Ile Val 
        35                  40                  45              


Glu Asp Ile Glu Pro Gly Ile Tyr Tyr Gly Ile Ser Asn Glu Asn Tyr 
    50                  55                  60                  


His Ala Gly Pro Gly Ile Ser Lys Ser Gln Leu Asp Asp Ile Ala Asp 
65                  70                  75                  80  


Thr Pro Ala Leu Tyr Leu Trp Arg Lys Asn Ala Pro Val Asp Thr Thr 
                85                  90                  95      


Lys Thr Lys Thr Leu Asp Leu Gly Thr Ala Phe His Cys Arg Val Leu 
            100                 105                 110         


Glu Pro Glu Glu Phe Ser Asn Arg Phe Ile Val Ala Pro Glu Phe Asn 
        115                 120                 125             


Arg Arg Thr Asn Ala Gly Lys Glu Glu Glu Lys Ala Phe Leu Met Glu 
    130                 135                 140                 


Cys Ala Ser Thr Gly Lys Thr Val Ile Thr Ala Glu Glu Gly Arg Lys 
145                 150                 155                 160 


Ile Glu Leu Met Tyr Gln Ser Val Met Ala Leu Pro Leu Gly Gln Trp 
                165                 170                 175     


Leu Val Glu Ser Ala Gly His Ala Glu Ser Ser Ile Tyr Trp Glu Asp 
            180                 185                 190         


Pro Glu Thr Gly Ile Leu Cys Arg Cys Arg Pro Asp Lys Ile Ile Pro 
        195                 200                 205             


Glu Phe His Trp Ile Met Asp Val Lys Thr Thr Ala Asp Ile Gln Arg 
    210                 215                 220                 


Phe Lys Thr Ala Tyr Tyr Asp Tyr Arg Tyr His Val Gln Asp Ala Phe 
225                 230                 235                 240 


Tyr Ser Asp Gly Tyr Glu Ala Gln Phe Gly Val Gln Pro Thr Phe Val 
                245                 250                 255     


Phe Leu Val Ala Ser Thr Thr Ile Glu Cys Gly Arg Tyr Pro Val Glu 
            260                 265                 270         


Ile Phe Met Met Gly Glu Glu Ala Lys Leu Ala Gly Gln Gln Glu Tyr 
        275                 280                 285             


His Arg Asn Leu Arg Thr Leu Ser Asp Cys Leu Asn Thr Asp Glu Trp 
    290                 295                 300                 


Pro Ala Ile Lys Thr Leu Ser Leu Pro Arg Trp Ala Lys Glu Tyr Ala 
305                 310                 315                 320 


Asn Asp Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu 
                325                 330                 335     


Pro Lys Lys Lys Arg Lys Val 
            340             


<210>  99
<211>  617
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic exonuclease

<400>  99

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Lys Gln Gln Ile Gln Leu Arg Arg Arg Glu Val Asp 
            20                  25                  30          


Glu Thr Ala Asp Leu Pro Ala Glu Leu Pro Pro Leu Leu Arg Arg Leu 
        35                  40                  45              


Tyr Ala Ser Arg Gly Val Arg Ser Ala Gln Glu Leu Glu Arg Ser Val 
    50                  55                  60                  


Lys Gly Met Leu Pro Trp Gln Gln Leu Ser Gly Val Glu Lys Ala Val 
65                  70                  75                  80  


Glu Ile Leu Tyr Asn Ala Phe Arg Glu Gly Thr Arg Ile Ile Val Val 
                85                  90                  95      


Gly Asp Phe Asp Ala Asp Gly Ala Thr Ser Thr Ala Leu Ser Val Leu 
            100                 105                 110         


Ala Met Arg Ser Leu Gly Cys Ser Asn Ile Asp Tyr Leu Val Pro Asn 
        115                 120                 125             


Arg Phe Glu Asp Gly Tyr Gly Leu Ser Pro Glu Val Val Asp Gln Ala 
    130                 135                 140                 


His Ala Arg Gly Ala Gln Leu Ile Val Thr Val Asp Asn Gly Ile Ser 
145                 150                 155                 160 


Ser His Ala Gly Val Glu His Ala Arg Ser Leu Gly Ile Pro Val Ile 
                165                 170                 175     


Val Thr Asp His His Leu Pro Gly Asp Thr Leu Pro Ala Ala Glu Ala 
            180                 185                 190         


Ile Ile Asn Pro Asn Leu Arg Asp Cys Asn Phe Pro Ser Lys Ser Leu 
        195                 200                 205             


Ala Gly Val Gly Val Ala Phe Tyr Leu Met Leu Ala Leu Arg Thr Phe 
    210                 215                 220                 


Leu Arg Asp Gln Gly Trp Phe Asp Glu Arg Asn Ile Ala Ile Pro Asn 
225                 230                 235                 240 


Leu Ala Glu Leu Leu Asp Leu Val Ala Leu Gly Thr Val Ala Asp Val 
                245                 250                 255     


Val Pro Leu Asp Ala Asn Asn Arg Ile Leu Thr Trp Gln Gly Met Ser 
            260                 265                 270         


Arg Ile Arg Ala Gly Lys Cys Arg Pro Gly Ile Lys Ala Leu Leu Glu 
        275                 280                 285             


Val Ala Asn Arg Asp Ala Gln Lys Leu Ala Ala Ser Asp Leu Gly Phe 
    290                 295                 300                 


Ala Leu Gly Pro Arg Leu Asn Ala Ala Gly Arg Leu Asp Asp Met Ser 
305                 310                 315                 320 


Val Gly Val Ala Leu Leu Leu Cys Asp Asn Ile Gly Glu Ala Arg Val 
                325                 330                 335     


Leu Ala Asn Glu Leu Asp Ala Leu Asn Gln Thr Arg Lys Glu Ile Glu 
            340                 345                 350         


Gln Gly Met Gln Ile Glu Ala Leu Thr Leu Cys Glu Lys Leu Glu Arg 
        355                 360                 365             


Ser Arg Asp Thr Leu Pro Gly Gly Leu Ala Met Tyr His Pro Glu Trp 
    370                 375                 380                 


His Gln Gly Val Val Gly Ile Leu Ala Ser Arg Ile Lys Glu Arg Phe 
385                 390                 395                 400 


His Arg Pro Val Ile Ala Phe Ala Pro Ala Gly Asp Gly Thr Leu Lys 
                405                 410                 415     


Gly Ser Gly Arg Ser Ile Gln Gly Leu His Met Arg Asp Ala Leu Glu 
            420                 425                 430         


Arg Leu Asp Thr Leu Tyr Pro Gly Met Met Leu Lys Phe Gly Gly His 
        435                 440                 445             


Ala Met Ala Ala Gly Leu Ser Leu Glu Glu Asp Lys Phe Lys Leu Phe 
    450                 455                 460                 


Gln Gln Arg Phe Gly Glu Leu Val Thr Glu Trp Leu Asp Pro Ser Leu 
465                 470                 475                 480 


Leu Gln Gly Glu Val Val Ser Asp Gly Pro Leu Ser Pro Ala Glu Met 
                485                 490                 495     


Thr Met Glu Val Ala Gln Leu Leu Arg Asp Ala Gly Pro Trp Gly Gln 
            500                 505                 510         


Met Phe Pro Glu Pro Leu Phe Asp Gly His Phe Arg Leu Leu Gln Gln 
        515                 520                 525             


Arg Leu Val Gly Glu Arg His Leu Lys Val Met Val Glu Pro Val Gly 
    530                 535                 540                 


Gly Gly Pro Leu Leu Asp Gly Ile Ala Phe Asn Val Asp Thr Ala Leu 
545                 550                 555                 560 


Trp Pro Asp Asn Gly Val Arg Glu Val Gln Leu Ala Tyr Lys Leu Asp 
                565                 570                 575     


Ile Asn Glu Phe Arg Gly Asn Arg Ser Leu Gln Ile Ile Ile Asp Asn 
            580                 585                 590         


Ile Trp Pro Ile Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu 
        595                 600                 605             


Phe Glu Pro Lys Lys Lys Arg Lys Val 
    610                 615         


<210>  100
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic exonuclease

<400>  100

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ser Lys Ser Trp Gly Lys Phe Ile Glu Glu Glu Glu Ala 
            20                  25                  30          


Glu Met Ala Ser Arg Arg Asn Leu Met Ile Val Asp Gly Thr Asn Leu 
        35                  40                  45              


Gly Phe Arg Phe Lys His Asn Asn Ser Lys Lys Pro Phe Ala Ser Ser 
    50                  55                  60                  


Tyr Val Ser Thr Ile Gln Ser Leu Ala Lys Ser Tyr Ser Ala Arg Thr 
65                  70                  75                  80  


Thr Ile Val Leu Gly Asp Lys Gly Lys Ser Val Phe Arg Leu Glu His 
                85                  90                  95      


Leu Pro Glu Tyr Lys Gly Asn Arg Asp Glu Lys Tyr Ala Gln Arg Thr 
            100                 105                 110         


Glu Glu Glu Lys Ala Leu Asp Glu Gln Phe Phe Glu Tyr Leu Lys Asp 
        115                 120                 125             


Ala Phe Glu Leu Cys Lys Thr Thr Phe Pro Thr Phe Thr Ile Arg Gly 
    130                 135                 140                 


Val Glu Ala Asp Asp Met Ala Ala Tyr Ile Val Lys Leu Ile Gly His 
145                 150                 155                 160 


Leu Tyr Asp His Val Trp Leu Ile Ser Thr Asp Gly Asp Trp Asp Thr 
                165                 170                 175     


Leu Leu Thr Asp Lys Val Ser Arg Phe Ser Phe Thr Thr Arg Arg Glu 
            180                 185                 190         


Tyr His Leu Arg Asp Met Tyr Glu His His Asn Val Asp Asp Val Glu 
        195                 200                 205             


Gln Phe Ile Ser Leu Lys Ala Ile Met Gly Asp Leu Gly Asp Asn Ile 
    210                 215                 220                 


Arg Gly Val Glu Gly Ile Gly Ala Lys Arg Gly Tyr Asn Ile Ile Arg 
225                 230                 235                 240 


Glu Phe Gly Asn Val Leu Asp Ile Ile Asp Gln Leu Pro Leu Pro Gly 
                245                 250                 255     


Lys Gln Lys Tyr Ile Gln Asn Leu Asn Ala Ser Glu Glu Leu Leu Phe 
            260                 265                 270         


Arg Asn Leu Ile Leu Val Asp Leu Pro Thr Tyr Cys Val Asp Ala Ile 
        275                 280                 285             


Ala Ala Val Gly Gln Asp Val Leu Asp Lys Phe Thr Lys Asp Ile Leu 
    290                 295                 300                 


Glu Ile Ala Glu Gln Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser 
305                 310                 315                 320 


Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
                325                 330 


<210>  101
<211>  340
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic exonuclease

<400>  101

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Met Ala Leu Leu Asp Leu Lys Gln Phe Tyr Glu Leu Arg 
            20                  25                  30          


Glu Gly Cys Asp Asp Lys Gly Ile Leu Val Met Asp Gly Asp Trp Leu 
        35                  40                  45              


Val Phe Gln Ala Met Ser Ala Ala Glu Phe Asp Ala Ser Trp Glu Glu 
    50                  55                  60                  


Glu Ile Trp His Arg Cys Cys Asp His Ala Lys Ala Arg Gln Ile Leu 
65                  70                  75                  80  


Glu Asp Ser Ile Lys Ser Tyr Glu Thr Arg Lys Lys Ala Trp Ala Gly 
                85                  90                  95      


Ala Pro Ile Val Leu Ala Phe Thr Asp Ser Val Asn Trp Arg Lys Glu 
            100                 105                 110         


Leu Val Asp Pro Asn Tyr Lys Ala Asn Arg Lys Ala Val Lys Lys Pro 
        115                 120                 125             


Val Gly Tyr Phe Glu Phe Leu Asp Ala Leu Phe Glu Arg Glu Glu Phe 
    130                 135                 140                 


Tyr Cys Ile Arg Glu Pro Met Leu Glu Gly Asp Asp Val Met Gly Val 
145                 150                 155                 160 


Ile Ala Ser Asn Pro Ser Ala Phe Gly Ala Arg Lys Ala Val Ile Ile 
                165                 170                 175     


Ser Cys Asp Lys Asp Phe Lys Thr Ile Pro Asn Cys Asp Phe Leu Trp 
            180                 185                 190         


Cys Thr Thr Gly Asn Ile Leu Thr Gln Thr Glu Glu Ser Ala Asp Trp 
        195                 200                 205             


Trp His Leu Phe Gln Thr Ile Lys Gly Asp Ile Thr Asp Gly Tyr Ser 
    210                 215                 220                 


Gly Ile Ala Gly Trp Gly Asp Thr Ala Glu Asp Phe Leu Asn Asn Pro 
225                 230                 235                 240 


Phe Ile Thr Glu Pro Lys Thr Ser Val Leu Lys Ser Gly Lys Asn Lys 
                245                 250                 255     


Gly Gln Glu Val Thr Lys Trp Val Lys Arg Asp Pro Glu Pro His Glu 
            260                 265                 270         


Thr Leu Trp Asp Cys Ile Lys Ser Ile Gly Ala Lys Ala Gly Met Thr 
        275                 280                 285             


Glu Glu Asp Ile Ile Lys Gln Gly Gln Met Ala Arg Ile Leu Arg Phe 
    290                 295                 300                 


Asn Glu Tyr Asn Phe Ile Asp Lys Glu Ile Tyr Leu Trp Arg Pro Ser 
305                 310                 315                 320 


Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Pro Lys Lys 
                325                 330                 335     


Lys Arg Lys Val 
            340 


<210>  102
<211>  283
<212>  DNA
<213>  Homo sapiens

<400>  102
ctgtgaggat tgagtgagtt gcacgtgtca agtgcttaga gcaggcgtgc tgcacacagc       60

aggcctttgg tcaggttggc tgctgggctg gccctggggc cgtttccctc actcctgctc      120

ggtgaatttg gctcagcagg cacctgcctc agctgctcac ttgagcctct gggtctagaa      180

ccctctgggg accgtttgag gagtgttcag tctccgtgaa cgttccctta gcactctgcc      240

acttattggg tcagctgtta acatcagtac gttaatgttt cct                        283


<210>  103
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic spacer sequence

<400>  103
cctcactcct gctcggtgaa ttt                                               23


<210>  104
<211>  298
<212>  DNA
<213>  Homo sapiens

<400>  104
gagtcaagga acacggataa agacgctggg agattgacat gcatttcgac caatagcatt       60

gcagagaggc gtatcatttc gcggatgttc caatcagtac gcagagagtc gccgtctcca      120

aggtgaaagc ggaagtaggg ccttcgcgca cctcatggaa tcccttctgc agcacctgga      180

tcgcttttcc gagcttctgg cggtctcaag cactacctac gtcagcacct gggaccccgc      240

caccgtgcgc cgggccttgc agtgggcgcg ctacctgcgc cacatccatc ggcgcttt        298


<210>  105
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic spacer sequence

<400>  105
gcggatgttc caatcagtac gca                                               23


<210>  106
<211>  1367
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic nCas9

<400>  106

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  107
<211>  1367
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic enCas9

<400>  107

Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Ala Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Ala Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Ala Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  108
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  108
gacaagaagt acagcatcgg gctggcgatc gggaccaact ccgtcggctg ggctgtgatt       60

accgacgagt acaaggtgcc atccaagaag ttcaaggtcc tcggcaacac tgaccggcac      120

agcattaaga agaacctgat tggggcgctg ctgttcgatt cgggggagac tgcggaggcg      180

accaggctga agcggactgc gcgccggagg tacaccagga ggaagaatcg gatctgctac      240

ctccaggaga ttttctcgaa tgagatggcc aaggtggacg attccttctt ccatcgcctg      300

gaggagtcgt tcctcgttga ggaggacaag aagcatgaga ggcatcccat tttcgggaat      360

atcgttgacg aggtggctta ccatgagaag tacccgacca tctaccatct gcggaagaag      420

ctcgtcgatt cgaccgataa ggccgacctg cggctgatct acctggccct cgcgcacatg      480

attaagttcc ggggccattt cctcatcgag ggcgacctca acccggacaa ctcggacgtg      540

gataagctct tcattcagct cgtgcagaca tacaaccagc tcttcgagga gaatcccatt      600

aacgcctcgg gggtcgacgc taaggctatt ctctcggctc ggctgtcgaa gtcgcgccgg      660

ctggagaatc tcattgccca gctcccaggc gagaagaaga acggcctctt cggcaacctg      720

attgccctgt cgctggggct cacaccgaat ttcaagtcga acttcgacct cgccgaggac      780

gctaagctcc agctcagcaa ggatacttac gatgatgacc tcgataacct gctcgcccag      840

attggggatc agtacgcgga tctgttcctc gcggccaaga atctcagcga tgctattctc      900

ctgtcggaca ttctccgcgt caacacagag attactaagg ccccactgtc ggcgagcatg      960

attaagaggt acgatgagca tcatcaggac ctgacactgc tcaaggcgct ggtccggcag     1020

cagctccccg agaagtacaa ggagattttc ttcgatcagt caaagaatgg gtacgcgggc     1080

tacattgatg gcggcgcgtc ccaggaggag ttctacaagt tcattaagcc catcctggag     1140

aagatggacg ggaccgagga gctgctggtg aagctcaatc gggaggacct gctccggaag     1200

cagcgcacat tcgacaatgg ctcgattcct caccagattc acctgggcga gctgcacgcc     1260

attctccgca ggcaggagga cttctacccg ttcctcaagg acaaccgcga gaagatcgag     1320

aagatcctga ccttccggat tccatactac gtggggccgc tcgcgcgggg gaactcccgg     1380

ttcgcgtgga tgactcgcaa gtccgaagaa acgattacac cgtggaattt cgaggaggtc     1440

gtcgacaagg gcgctagtgc gcagtcattc attgagagga tgaccaattt cgataagaac     1500

ctgcctaacg agaaggtgct gccgaagcat tcgctgctct acgagtactt caccgtttac     1560

aatgagctga ccaaggtgaa gtatgtgact gagggcatga ggaagccagc gttcctgagc     1620

ggcgagcaga agaaggctat cgtggacctg ctcttcaaga ctaaccggaa ggtgactgtg     1680

aagcagctca aggaggacta cttcaagaag attgagtgct tcgattccgt tgagattagc     1740

ggggtggagg atcggttcaa tgcttcgctc gggacatacc acgatctcct gaagatcatt     1800

aaggataagg acttcctcga caacgaggag aacgaggaca ttctcgaaga tattgtcctg     1860

accctcaccc tcttcgagga tcgggagatg atcgaggaga ggctcaagac atacgctcat     1920

ctgttcgatg ataaggtcat gaagcagctg aagcgcaggc ggtacacagg gtgggggcgg     1980

ctgagccgga agctgatcaa cgggattcgg gataagcagt ccgggaagac aattctcgac     2040

ttcctcaagt ccgacgggtt cgctaaccgg aacttcatgc agctcattca tgatgactcg     2100

ctgacattca aggaggatat tcagaaggcg caggtttcgg ggcagggcga ctcgctccac     2160

gagcatattg cgaatctggc gggctccccc gcgattaaga agggcattct gcaaaccgtc     2220

aaggtggttg atgagctggt caaggtcatg gggcggcata agccagagaa tattgtcatc     2280

gagatggcgc gggagaatca gaccacacag aaggggcaga agaactcacg ggagcggatg     2340

aagcgcatcg aggagggcat caaggagctg gggtcgcaga tcctgaagga gcatcccgtg     2400

gagaacactc agctgcaaaa tgagaagctg tacctctact acctccagaa cgggagggac     2460

atgtatgtgg atcaggagct ggatattaat aggctgagcg attacgatgt cgaccacatt     2520

gtcccacagt cgttcctgaa ggacgacagc attgacaaca aggtgctgac ccgctcggat     2580

aagaacaggg gcaagagcga taatgttcca agcgaggagg ttgtgaagaa gatgaagaac     2640

tactggcggc agctcctgaa cgcgaagctc atcacacagc ggaagttcga caacctcacc     2700

aaggctgagc gcgggggcct gagcgagctg gacaaggcgg ggttcattaa gaggcagctg     2760

gtcgagacac ggcagattac aaagcatgtt gcgcagattc tcgattcccg gatgaacacc     2820

aagtacgatg agaacgataa gctgattcgg gaggtcaagg taattaccct gaagtccaag     2880

ctggtgtccg acttcaggaa ggacttccag ttctacaagg ttcgggagat caacaactac     2940

caccacgcgc atgatgccta cctcaacgcg gtcgtgggga ccgctctcat caagaagtac     3000

ccaaagctgg agtcagagtt cgtctacggg gattacaagg tttacgacgt gcggaagatg     3060

atcgctaaga gcgagcagga gattggcaag gctaccgcta agtacttctt ctactccaac     3120

atcatgaact tcttcaagac agagattacc ctcgcgaatg gcgagatccg gaagaggccc     3180

ctcatcgaga caaatgggga gacaggggag attgtctggg ataaggggcg ggatttcgcg     3240

accgtccgga aggtcctgtc gatgccccag gttaatattg tcaagaagac tgaggtccag     3300

actggcggct tctcaaagga gtcgattctc ccaaagagga actccgataa gctcattgct     3360

cggaagaagg attgggaccc caagaagtac gggggattcg actcccccac tgttgcttac     3420

tctgttctgg ttgttgctaa ggtggagaag gggaagtcga agaagctgaa gagcgtgaag     3480

gagctgctcg ggattacaat tatggagagg tcatccttcg agaagaatcc catcgacttc     3540

ctggaggcca agggctacaa ggaggtgaag aaggacctga ttattaagct gcccaagtac     3600

tcgctcttcg agctggagaa tgggcggaag cggatgctgg cgtccgcggg ggagctgcaa     3660

aaggggaacg agctggcgct cccctccaag tatgtgaact tcctctacct ggcgtcgcac     3720

tacgagaagc tgaaggggtc cccagaggat aatgagcaga agcagctctt cgtcgagcag     3780

cataagcact acctggacga gattatcgag cagattagcg agttctcgaa gcgggtcatc     3840

ctcgcggatg cgaacctgga taaggtgctc agcgcctaca ataagcaccg ggacaagccg     3900

attcgggagc aggcggagaa tattattcac ctcttcacac tcaccaacct cggggcacca     3960

gctgcgttca agtacttcga cactactatc gaccggaagc ggtacacctc gacgaaggag     4020

gtgctcgacg ccaccctcat tcaccagtcg atcacaggcc tgtacgagac acggattgac     4080

ctgtcccagc tcgggggcga c                                               4101


<210>  109
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  109
gacaagaagt actccattgg cctggcgatt gggacaaact cggtggggtg ggccgtgatt       60

acggatgagt acaaggttcc aagcaagaag ttcaaggtcc tcgggaacac agatcggcat      120

tcgattaaga agaatctcat tggggcgctc ctcttcgact cgggggagac agcggaggct      180

accaggctca agcggacagc caggcggcgg tacacaaggc ggaagaatcg catctgctac      240

ctccaggaga ttttctcgaa tgagatggcg aaggtggacg acagcttctt ccatcggctg      300

gaggagtcct tcctggtgga ggaggataag aagcacgaga ggcatccaat tttcgggaac      360

atcgtggacg aggttgcgta ccatgagaag taccctacaa tctaccatct gcggaagaag      420

ctggttgact ccacagacaa ggcggacctg aggctgatct acctcgctct ggcccacatg      480

attaagttcc gcgggcattt cctgatcgag ggggacctga atcccgacaa ttcggatgtg      540

gacaagctct tcatccagct ggtgcagacc tacaaccagc tgttcgagga gaatcccatc      600

aatgcgtcgg gcgttgacgc taaggccatt ctgtccgcta ggctgtcgaa gagcaggagg      660

ctggagaacc tgatcgccca gctgccaggc gagaagaaga atgggctctt cgggaatctg      720

attgcgctct ccctggggct gacaccgaac ttcaagagca atttcgatct ggctgaggac      780

gcgaagctcc agctctcgaa ggacacttac gacgatgacc tcgataacct cctcgcgcag      840

atcggggacc agtacgctga tctcttcctc gccgctaaga acctctcgga tgctatcctg      900

ctctccgaca ttctccgggt taataccgag attacaaagg ccccactgtc ggcgtccatg      960

atcaagcggt acgatgagca tcatcaggat ctcaccctgc tcaaggccct cgtgcggcag     1020

cagctgcccg agaagtacaa ggagattttc ttcgaccaga gcaagaatgg gtacgctggc     1080

tacattgacg gcggggcctc acaggaggag ttctacaagt tcatcaagcc aatcctggag     1140

aagatggatg ggacagagga gctgctggtg aagctcaacc gggaggatct gctcaggaag     1200

cagcggacgt tcgacaacgg gtcgattccc catcagatcc acctggggga gctgcacgcg     1260

atcctgcgcc ggcaggagga tttctaccct ttcctgaagg ataatcggga gaagatcgag     1320

aagattctca ccttccggat tccctactac gtcgggccac tcgcgcgggg caatagcagg     1380

ttcgcctgga tgacacggaa gagcgaggag acaatcaccc cctggaactt cgaggaggtt     1440

gtcgacaagg gggcgtccgc ccagtcattc attgagcgga tgaccaattt cgacaagaat     1500

ctgccaaatg agaaggttct cccaaagcat agcctcctct acgagtactt cactgtttac     1560

aacgagctga ccaaggtgaa gtatgtgacc gagggcatgc ggaagcccgc gttcctgtcc     1620

ggcgagcaga agaaggccat tgtggacctc ctgttcaaga ccaatcgcaa ggtcacagtc     1680

aagcagctca aggaggatta cttcaagaag atcgagtgct tcgactcggt tgagattagc     1740

ggggtggagg atcggttcaa cgcgagcctc ggcacttacc acgacctcct gaagatcatc     1800

aaggataagg acttcctcga caacgaggag aacgaggata ttctggagga catcgtgctc     1860

accctgacgc tgttcgagga tcgggagatg atcgaggagc gcctgaagac ctacgctcat     1920

ctcttcgatg ataaggtcat gaagcagctg aagaggaggc ggtacaccgg gtggggccgc     1980

ctgagcagga agctcattaa cgggatcagg gacaagcaga gcggcaagac catcctggac     2040

ttcctcaaga gcgatggctt cgccaaccgg aatttcatgc agctcatcca cgacgactcc     2100

ctcaccttca aggaggacat tcagaaggct caggtcagcg gccagggcga ctcgctgcat     2160

gagcacatcg ctaacctggc gggcagccca gccatcaaga agggcatcct ccagacagtg     2220

aaggtcgtgg atgagctggt gaaggtcatg ggccggcata agcccgagaa tattgtgatt     2280

gagatggcgc gggagaatca gaccactcag aagggccaga agaactcgcg ggagcgcatg     2340

aagaggatcg aggaggggat taaggagctg ggcagccaga ttctcaagga gcaccccgtg     2400

gagaataccc agctccagaa cgagaagctg tacctctact acctccagaa tgggcgggac     2460

atgtatgttg atcaggagct ggacatcaat cgcctctcgg attacgacgt ggaccacatc     2520

gtgccccaga gcttcctgaa ggatgatagc atcgacaata aggtcctgac ccgctccgac     2580

aagaatcgcg gcaagagcga caacgtgccg agcgaggagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgcgaagctc attacacagc ggaagttcga taacctgacg     2700

aaggcggaga ggggcggcct ctccgagctg gacaaggcgg gcttcattaa gaggcagctc     2760

gtggagactc gccagatcac caagcacgtg gctcagatcc tcgatagccg gatgaatacg     2820

aagtacgatg agaatgacaa gctcatccgg gaggtgaagg taatcaccct gaagtcaaag     2880

ctcgttagcg atttccggaa ggacttccag ttctacaagg tgcgggagat taacaactac     2940

catcatgcgc acgatgcgta cctcaatgcg gtggtgggca cagccctgat taagaagtac     3000

cccaagctgg agagcgagtt cgtctacggg gactacaagg tgtacgatgt tcggaagatg     3060

atcgccaaga gcgagcagga gattgggaag gccaccgcta agtacttctt ctactcgaat     3120

attatgaatt tcttcaagac cgagatcaca ctcgctaatg gggagattcg gaagcggccc     3180

ctcatcgaga ctaacgggga gactggcgag attgtgtggg acaaggggcg cgacttcgct     3240

accgtgcgca aggtcctctc gatgccccag gttaatattg ttaagaagac agaggtgcag     3300

acgggcgggt tctccaagga gtctatcctg ccgaagcgga actcggacaa gctgatcgcc     3360

cgcaagaagg attgggaccc caagaagtac gggggattcg atagcccaac cgtggcttac     3420

agcgtcctgg tggtcgccaa ggttgagaag gggaagtcga agaagctcaa gagcgttaag     3480

gagctgctgg gcatcaccat catggagcgg tccagcttcg agaagaatcc tatcgacttc     3540

ctggaggcta aggggtacaa ggaggtcaag aaggacctga tcattaagct gcccaagtac     3600

tctctgttcg agctggagaa cgggaggaag cggatgctgg cgtctgctgg cgagctacag     3660

aagggcaatg agctggcgct cccctcgaag tatgtcaact tcctctacct ggcttcccat     3720

tacgagaagc tgaagggctc gcccgaggat aatgagcaga agcagctctt cgtggagcag     3780

cacaagcact acctcgacga gatcattgag cagatttcgg agttctcgaa gcgggtcatt     3840

ctcgcggacg cgaacctcga caaggtcctc tcggcgtaca acaagcaccg ggacaagccc     3900

atccgggagc aggccgagaa cattatccac ctcttcacac tgaccaacct cggcgctccc     3960

gccgcgttca agtacttcga caccaccatt gaccgcaaga gatacacatc caccaaggag     4020

gtgctggacg cgaccctcat ccaccagagc atcacaggcc tctacgagac acggatcgac     4080

ctctcgcagc tcgggggcga t                                               4101


<210>  110
<211>  4092
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  110
gacaagaagt actcgatcgg cctggcgatt ggcacaaaca gcgtggggtg ggctgtgatc       60

actgatgagt acaaggtgcc atcgaagaag ttcaaggtgc tggggaatac agaccggcat      120

tcgatcaaga agaatctcat tggcgctctc ctcttcgatt ccggcgagac tgctgaggcg      180

acccgcctga agcgcaccgc ccggcggcgc tacactcggc ggaagaatag gatttgctac      240

ctccaggaga ttttctcgaa tgagatggcc aaggtggatg acagcttctt ccaccgcctg      300

gaggagtcgt tcctggtcga ggaggacaag aagcatgagc ggcaccctat cttcgggaat      360

atcgttgatg aggtcgccta ccacgagaag taccccacta tctaccatct ccgcaagaag      420

ctcgtggaca gcacagataa ggccgacctc cgcctgatct acctcgccct cgcgcacatg      480

attaagttcc gggggcactt cctcattgag ggggatctga atcccgataa ctccgacgtg      540

gacaagctgt tcatccagct ggtgcagaca tacaaccagc tgttcgagga gaatcccatc      600

aacgcgagcg gcgtggacgc taaggccatt ctgtcggcta ggctctcgaa gtcgaggcgg      660

ctggagaacc tgattgcgca gctccccggc gagaagaaga acgggctgtt cgggaatctc      720

atcgccctct ccctcggcct cacaccaaac ttcaagagca atttcgacct ggctgaggac      780

gctaagctgc aactctcaaa ggatacatac gatgacgacc tggacaatct cctggctcag      840

atcggcgacc agtacgctga cctgttcctc gcggccaaga atctgtcgga cgcgattctc      900

ctcagcgaca tcctgcgcgt caataccgag attacgaagg ctccactgtc tgcgtcaatg      960

attaagcggt acgatgagca tcaccaggat ctgaccctcc tgaaggcgct cgtgcggcag     1020

cagctgcccg agaagtacaa ggagattttc ttcgatcaga gcaagaatgg ctacgccggc     1080

tacatcgacg ggggcgcgag ccaggaggag ttctacaagt tcatcaagcc catcctggag     1140

aagatggacg gcaccgagga gctactcgtg aagctcaatc gggaggatct cctccggaag     1200

cagcggacat tcgataacgg gtctatccca caccagatcc acctcggcga gctgcatgcg     1260

attctgcggc ggcaggagga tttctaccct ttcctgaagg acaaccggga gaagatcgag     1320

aagatcctca cattccggat tccatactac gtcggccccc tggcgagggg caatagccgg     1380

ttcgcgtgga tgacaaggaa gtccgaggag actattaccc cgtggaattt cgaggaggtg     1440

gttgacaagg gcgcttccgc gcagagcttc attgagcgga tgacaaactt cgacaagaat     1500

ctccccaacg agaaggtcct gccgaagcat agcctcctgt acgagtactt caccgtctac     1560

aatgagctaa ctaaggtcaa gtatgtgaca gagggcatga ggaagccagc cttcctctca     1620

ggcgagcaga agaaggccat tgtggacctc ctgttcaaga caaaccgcaa ggtgacagtg     1680

aagcagctga aggaggatta cttcaagaag attgagtgct tcgactcagt ggagatttca     1740

ggcgtggagg atcggttcaa cgcgagcctg gggacttacc acgacctgct gaagattatt     1800

aaggacaagg acttcctgga taacgaggag aatgaggaca tcctggagga tattgtgctc     1860

accctcaccc tgttcgagga cagggagatg attgaggaga ggctcaagac ctacgcgcac     1920

ctgttcgatg acaaggtcat gaagcagctg aagaggcggc gctacactgg gtggggccgc     1980

ctgtcgcgga agctgatcaa cggcattcgg gataagcagt ccgggaagac cattctggat     2040

ttcctgaagt cggacggctt cgccaacagg aatttcatgc agctgatcca cgacgactcc     2100

ctcaccttca aggaggacat tcagaaggcc caggttagcg gccaggggga ctcactccac     2160

gagcatattg ccaatctggc cggctctcca gctatcaaga agggcatcct gcaaacagtt     2220

aaggttgttg acgagctggt taaggtcatg gggcggcata agcccgagaa cattgtcatc     2280

gagatggctc gggagaacca gacaactcag aagggccaga agaactccag ggagcgcatg     2340

aagcggattg aggagggcat taaggagctg gggtcccaga tcctcaagga gcaccctgtc     2400

gagaacactc agctgcaaaa cgagaagctc tacctgtact acctccagaa cgggcgggat     2460

atgtatgtgg atcaggagct ggacatcaac aggctctccg actacgacgt ggatcacatt     2520

gtcccacagt ctttcctcaa ggatgattcc atcgacaaca aggtgctgac gcgcagcgac     2580

aagaataggg ggaagtcgga caacgttccg agcgaggagg tcgtgaagaa gatgaagaat     2640

tactggaggc agctcctgaa tgcgaagctg atcactcaga ggaagttcga caatctgaca     2700

aaggcggaga ggggcgggct ctcggagctg gataaggcgg gcttcatcaa gcggcagctc     2760

gttgaaaccc ggcagatcac caagcatgtc gcccagatcc tcgatagccg catgaacacc     2820

aagtacgatg agaacgacaa gctcattcgg gaggttaagg tcattacgct gaagtccaag     2880

ctcgtcagcg acttcaggaa ggatttccag ttctacaagg ttcgggagat taacaactac     2940

caccacgcgc atgatgcgta cctgaacgct gttgtcggca ctgctctcat caagaagtac     3000

ccaaagctgg agtccgagtt cgtctacggg gactacaagg tctacgatgt ccggaagatg     3060

atcgccaagt cggagcagga gatcgggaag gctactgcga agtacttctt ctacagcaac     3120

attatgaatt tcttcaagac ggagattacg ctggcgaacg gggagattag gaagaggccc     3180

ctcattgaga ctaatgggga gacaggcgag attgtttggg acaagggccg cgacttcgcg     3240

actgtgcgga aggtcctgtc catgccacag gtgaatattg ttaagaagac agaggtgcag     3300

actgggggct tctcgaagga gagcattctc ccaaagcgga acagcgataa gctcatcgcg     3360

cgcaagaagg attgggaccc taagaagtac ggcggcttcg attctcccac tgtggcctac     3420

tccgttctcg tggttgccaa ggttgagaag gggaagtcga agaagctgaa gtcggtcaag     3480

gagctgctcg ggattacaat catggagcgg agcagcttcg agaagaaccc tattgatttc     3540

ctggaggcca agggctacaa ggaggttaag aaggatctca ttatcaagct ccctaagtac     3600

tctctgttcg agctggagaa tggccggaag aggatgctgg cctcggctgg cgagctacag     3660

aaggggaatg agctggccct cccgtcgaag tatgtgaatt tcctgtacct cgcgtcgcac     3720

tacgagaagc tcaagggcag cccggaggat aatgagcaga agcagctctt cgtggagcag     3780

cataagcact acctggacga gatcattgag cagatcagcg agttctcgaa gcgggttatt     3840

ctggctgatg ctaacctgga caaggttctg agcgcctaca ataagcatcg cgacaagccg     3900

attcgcgagc aggcggagaa tattatccac ctgttcaccc tcactaacct cggggctccc     3960

gcggccttca agtacttcga taccacaata gataggaagc ggtacacctc gacgaaggag     4020

gtcctcgacg ccacactcat ccatcagtcg attacaggcc tgtacgagac acggattgac     4080

ctctcgcagc tg                                                         4092


<210>  111
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  111
gacaagaagt attccatagg cctggctatc ggcaccaaca gcgtgggctg ggccgtcatc       60

accgacgagt acaaagtgcc gagtaaaaag ttcaaagtgc tcggcaacac cgaccgccac      120

tccataaaga aaaacctgat cggggcgctc ctgttcgaca gcggcgagac ggcggaggcc      180

acccgcttga aacgcacggc ccgacggcgc tacacgcggc gcaagaaccg gatctgttac      240

ctacaggaga ttttctctaa cgagatggcg aaggtggacg actcgttctt tcaccgcctc      300

gaagagtcct tcctcgtgga ggaggacaag aaacacgagc gccacccgat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag tacccgacca tctaccacct ccggaagaaa      420

ctcgtggaca gcacggacaa ggccgacctg aggctcatct acctcgccct ggcgcacatg      480

attaagttcc ggggccactt cctgatcgag ggcgacctga acccggacaa cagcgacgtg      540

gacaagctgt tcatccagct agtccagacc tacaaccagc ttttcgagga aaaccccatc      600

aacgccagcg gggtggacgc gaaggcgatc ctgtccgccc ggctgagcaa gtcccggcgg      660

ctggagaacc tcatcgcgca gttgcccggc gagaagaaga acgggctgtt cgggaacctg      720

atcgccctct ccctggggct caccccgaac ttcaagtcca acttcgacct cgccgaggac      780

gccaaactac agctgagcaa ggacacctac gacgacgacc tcgacaacct gctggcccag      840

atcggggacc agtacgcaga cctgttcctc gccgccaaga acctctccga cgccatcctg      900

ctgtcggaca tcctgcgggt gaacacggag atcacgaagg ccccgctctc ggcctcgatg      960

attaaacgct acgacgagca ccaccaggac ttgaccctcc tcaaggcgct ggtccgccag     1020

cagcttcccg agaagtacaa ggaaatcttt ttcgatcaga gcaagaacgg gtacgccggg     1080

tacatcgacg gcggggcgtc ccaggaggag ttctacaagt tcatcaagcc catcctggag     1140

aaaatggacg ggaccgagga gctgctcgtg aagctcaacc gcgaagattt gctccgcaag     1200

cagcgcacgt tcgacaacgg gtcgatcccg caccagatcc acctgggcga gctgcacgcg     1260

atcctcaggc gtcaggaaga cttctacccc ttcctcaagg acaaccgcga gaagatagag     1320

aagattctga ccttcagaat tccttattac gtgggcccgc tggctcgggg caactcgcgc     1380

ttcgcctgga tgacgcgcaa gtccgaggag accatcaccc cgtggaactt cgaggaggtg     1440

gtggataagg gtgcctcggc ccagtccttc atcgagcgga tgaccaactt cgacaagaac     1500

ctgccgaacg agaaggtgct ccccaagcac agcctgctct acgaatattt cacggtgtac     1560

aacgagctga cgaaggtcaa gtacgtgacc gagggaatga ggaaacctgc attcctctcc     1620

ggggagcaga agaaagccat agtcgacctc ctgttcaaga ccaaccggaa ggtcaccgtc     1680

aagcagctca aggaggacta cttcaagaag atcgagtgct tcgattcagt ggagatcagc     1740

ggcgtcgagg accggttcaa cgccagcctg ggcacctacc acgacctgct caagatcatc     1800

aaggacaagg acttcctcga caacgaggag aacgaggaca tcctggagga catcgtgctg     1860

accctgacgc tcttcgagga ccgcgagatg atcgaggagc gcctcaagac ctacgcccac     1920

ctgttcgacg acaaggtgat gaagcagctc aagcggcgga gatatactgg gtggggccgc     1980

ctctcccgga agctcattaa cggtatcagg gataagcagt ccgggaagac gatcctcgac     2040

ttcctcaagt cggacgggtt cgccaaccgc aacttcatgc agctcatcca cgacgactcc     2100

ctgacgttca aggaggacat ccagaaggcc caagtgtctg gtcaaggtga ctcgctccac     2160

gagcacatcg ccaacctcgc gggcagcccg gccatcaaga agggaatact ccagaccgtc     2220

aaggtggtgg acgagctggt gaaggtcatg ggccgccaca agccggagaa catcgtcatc     2280

gagatggcgc gggagaacca gaccacgcag aaggggcaga aaaatagccg tgagcgcatg     2340

aagcgcatcg aggaggggat taaggagttg ggcagccaga tcctcaagga gcaccctgtg     2400

gagaacacgc agttgcaaaa cgagaagctc tacctgtact acctccagaa cgggagggat     2460

atgtacgtgg accaagaact ggacatcaac cgcctgtccg actacgacgt ggaccacatc     2520

gtgccgcaga gcttcctcaa ggacgacagc atcgacaaca aggtgctcac ccggtccgac     2580

aagaatcggg gcaagtccga caacgtgccc agcgaggagg tcgtcaaaaa gatgaaaaac     2640

tactggcgac aactactgaa cgccaagctc atcacccagc gcaagttcga caacctcaca     2700

aaagccgagc gcggcgggtt gagcgagctg gacaaggccg ggttcatcaa gcgccagctc     2760

gtcgagacgc gccagatcac gaagcacgtc gcgcagatac tcgacagccg gatgaacacc     2820

aagtacgacg agaacgacaa gctcatccgg gaggtgaagg tcatcaccct caagtcgaag     2880

ctcgtgagcg acttccgcaa ggacttccag ttctacaagg tccgggagat caacaactac     2940

caccacgccc acgatgctta tcttaacgcc gtggtgggga cggccctcat taagaaatac     3000

ccgaagctgg agtcggagtt cgtgtacggc gactacaagg tgtacgacgt caggaagatg     3060

atcgccaagt ccgaacagga gatcgggaag gccacggcga aatacttctt ctacagcaac     3120

atcatgaact tcttcaagac cgagatcacc ctcgccaacg gcgagatccg caagcgcccg     3180

ctcatcgaga cgaacgggga gaccggcgag atcgtctggg acaaggggcg cgacttcgcc     3240

actgtgcgga aggtgctgtc gatgccccag gtcaacatcg tcaagaagac ggaggtccag     3300

acgggcgggt tcagcaagga gagcatcctg ccgaagcgca acagcgacaa gctgatcgcc     3360

cgcaaaaagg actgggatcc aaaaaagtac ggcggcttcg acagccccac cgtcgcctac     3420

agcgtcctcg tcgtcgctaa agtcgagaag ggcaagtcca aaaagctcaa gagcgtcaag     3480

gagctgctcg ggatcaccat catggagcgg tccagcttcg agaagaaccc aattgatttc     3540

ctggaggcga agggctacaa ggaggtcaag aaagacctca tcataaagct gccgaagtac     3600

tcactcttcg agctggagaa cgggcgcaag cggatgctgg cgtcggccgg agagctccaa     3660

aagggcaacg agctggcgct gccgagcaag tacgtgaact tcctctacct ggcgtcccac     3720

tacgagaagc tcaagggcag tccagaggat aacgagcaga agcagctatt cgtggagcag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gcgcgtcatc     3840

ctggcggacg ccaacctgga caaggtgctg tccgcgtaca acaagcaccg cgacaagccg     3900

atccgcgagc aagccgagaa catcatccac ctgttcaccc tcacgaacct cggggcaccc     3960

gccgccttca aatatttcga cacgaccatc gaccgcaagc gctacaccag cacgaaggag     4020

gtgctcgacg ccaccctgat ccaccagagc atcaccgggc tgtacgagac ccgcatcgac     4080

ctctcgcagc tcggcgggga c                                               4101


<210>  112
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  112
gacaagaagt acagtattgg attggccatc gggacgaaca gcgtgggctg ggccgtcatc       60

accgacgagt acaaggtgcc atccaagaag tttaaggttc tggggaatac cgaccgccac      120

tcgatcaaga aaaatctcat cggggcgctg cttttcgaca gcggcgagac ggcggaagcg      180

acgcggctca agcggacggc tcgtcgccgt tacacccggc gtaagaaccg catctgttac      240

ctccaggaga tattcagcaa cgagatggcg aaggtggacg actccttttt ccaccgtctt      300

gaggagtcct tcctggtcga ggaggacaag aagcacgagc gccacccgat cttcgggaac      360

atcgtggacg aggtggccta ccacgagaag taccccacga tctaccacct ccgcaaaaaa      420

ctcgtggact caactgacaa ggccgatttg aggcttatct acctcgccct cgcccacatg      480

attaagttcc gtgggcactt cctaatcgag ggtgacctca accccgacaa ctctgacgtg      540

gacaagctgt tcatccagct tgtgcagacc tacaatcagc tctttgagga gaatccgatc      600

aacgcatctg gtgtggacgc aaaggccatc ctcagcgcgc ggctgagcaa gtctaggcgg      660

ttggagaacc tgatcgccca actgcccggc gagaagaaaa atggcctctt cggcaacctg      720

atcgccctgt cgctggggct cacgccgaac ttcaagagta actttgacct ggcggaggac      780

gctaagctcc agctatctaa ggacacatac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctcttccta gccgccaaga acctgtccga cgccatcctc      900

ctcagcgaca tcctgcgcgt gaacacggag atcacgaagg ctccgctcag cgcctccatg      960

attaagcggt acgacgagca ccaccaagac ctaactttac tcaaagccct cgtgcggcag     1020

cagcttcccg agaagtacaa agagatattt tttgatcagt ccaagaacgg ttatgcgggc     1080

tacatcgacg gcggcgcgag ccaggaggag ttctacaagt tcatcaagcc catcctggag     1140

aagatggacg gcacggagga gctgctcgtg aagctcaacc gtgaagacct cctgcgaaag     1200

cagcgaacct tcgacaacgg ttcgatcccg caccagatcc acctcgggga gctgcacgcc     1260

atcctgaggc gacaggagga cttctaccct ttcctaaagg acaaccgcga gaagattgaa     1320

aaaatcctga cgtttcgcat accctactac gtcggcccgc tggcgcgcgg caactcccgg     1380

ttcgcctgga tgacccgtaa gagcgaggag acgatcaccc cgtggaactt cgaggaggtc     1440

gtggacaagg gcgcgagcgc gcagagcttc atcgagcgca tgaccaactt cgacaagaac     1500

ctcccgaacg agaaggtgct cccaaagcac tccctcctgt acgagtattt caccgtgtac     1560

aacgagttga caaaggtgaa gtacgtgacg gagggaatgc ggaagcctgc gttcctctcg     1620

ggcgagcaga agaaggcaat cgtggacctg ctcttcaaga ccaaccggaa ggtgacggtg     1680

aagcagctca aggaggacta cttcaaaaaa atcgagtgct tcgactccgt ggagataagc     1740

ggcgtggagg accgattcaa cgcctccctc ggcacctacc acgacctcct taagatcatc     1800

aaggacaagg acttcctgga caacgaggag aacgaggaca tcctggagga catcgtgctc     1860

accctgaccc tcttcgagga ccgggagatg atcgaggagc gcctcaagac gtacgcccac     1920

ttgttcgacg acaaggtgat gaagcagctc aagcggcggc gatacaccgg gtggggccgc     1980

ctatcccgca aacttatcaa cggcatccgc gacaagcagt ccggcaagac gatcctggat     2040

ttcctcaagt cggacgggtt cgccaaccgg aacttcatgc agctcatcca cgacgacagc     2100

ctcacgttca aggaggacat ccagaaggcc caagtgagcg gtcaagggga cagcctccac     2160

gagcacattg cgaaccttgc tgggagccct gcgatcaaga aggggatatt gcaaaccgtg     2220

aaggtcgtgg acgagttggt gaaggtcatg gggcgacaca agcccgagaa catcgtgatc     2280

gagatggcca gggaaaatca gaccacgcag aagggccaaa aaaacagccg cgagcggatg     2340

aagcggatcg aggagggcat caaggagctg gggtcgcaga tcctcaagga gcacccggtg     2400

gagaacacgc agctccagaa cgagaagctg tacctctatt acctacagaa cgggcgggat     2460

atgtacgtgg accaggagct agacatcaac cgcctgtccg actacgacgt ggaccatatc     2520

gtcccgcagt cgttcttgaa ggacgacagc atcgacaaca aggtgctcac aagatcggat     2580

aagaatcgag gcaagtccga caacgtgccc tcggaggagg tggtcaagaa aatgaaaaac     2640

tactggcggc agttgctgaa cgccaagctc attacgcagc ggaagttcga caacctgacg     2700

aaggctgaac gtggtgggct cagcgagcta gacaaggcgg ggttcatcaa gcggcagctc     2760

gtcgagaccc ggcagatcac caagcacgtg gcgcagatcc tggactcgcg catgaacacc     2820

aagtacgacg agaacgacaa gctcatccgt gaggtgaagg tcatcaccct taagtctaag     2880

ctggtcagtg acttccgcaa ggacttccag ttctacaagg tccgggagat caacaactac     2940

caccacgcgc acgacgccta cctcaacgcg gtggtgggga cggcgcttat taagaaatat     3000

cccaagctgg aaagcgagtt cgtttacggc gactacaagg tgtacgacgt ccgcaagatg     3060

atcgcaaagt cggaacagga aatcggaaag gcgacggcca aatatttctt ttactccaac     3120

atcatgaatt tttttaagac ggagatcacc ctggcgaacg gggagatccg caagcggccc     3180

ctcatcgaga ccaacgggga gacgggcgag atcgtctggg acaagggccg ggacttcgcc     3240

accgtgcgga aggtgctttc tatgcctcaa gtcaatatcg tcaaaaagac agaggtgcag     3300

accggcgggt tcagcaagga gtctatcctg ccgaagcgca actcggacaa gctcatcgcg     3360

cgcaagaaag actgggaccc caaaaaatat ggcgggttcg actcgccgac cgtcgcctac     3420

agcgtcctcg tggtggctaa ggtcgagaag ggcaagagca aaaagctaaa gtcggtgaag     3480

gagctgctgg gcatcaccat catggagcgc tcgtctttcg agaagaatcc aatcgacttc     3540

ctagaggcga aggggtacaa ggaggtcaaa aaggatctta tcatcaaact gccgaagtac     3600

agtctgttcg agctggagaa cgggcggaag cggatgctgg ctagtgcggg cgagttgcag     3660

aagggcaacg agttggcact gccctccaag tacgtgaact tcctgtacct ggcctcccac     3720

tacgagaagc tcaaggggag ccccgaggac aacgagcaga agcagctatt cgtcgagcag     3780

cacaagcact acctggacga gatcatcgag cagatcagtg agttctccaa gcgggtcatc     3840

ctcgcggacg ccaacctgga caaggtgctg agcgcgtaca acaagcacag ggacaagcca     3900

atcagggaac aggccgagaa catcatccac ctgttcaccc tgaccaacct gggtgcaccg     3960

gctgccttca agtactttga cacgaccatc gaccggaagc gctacacctc cacgaaggag     4020

gtgctggacg ccacgctgat ccaccagagc atcaccgggc tctacgagac acggatcgac     4080

ctgagccagc ttggcgggga c                                               4101


<210>  113
<211>  4092
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  113
gacaaaaagt attccattgg actcgctatc ggcacgaaca gcgtcgggtg ggcggtcatc       60

actgacgagt acaaggtgcc gagcaagaag tttaaggtgc tgggaaacac cgacaggcac      120

tcgatcaaga aaaatcttat cggggcccta ctcttcgact ccggagaaac cgccgaggcc      180

acccggttga agcgcacggc ccgccgtcgc tacaccaggc gcaagaaccg gatctgctac      240

ctccaggaga tattcagcaa tgagatggcg aaggtggacg actcgttttt tcacaggcta      300

gaggagtctt tcctcgtgga ggaggacaag aaacacgagc gccaccccat cttcggcaac      360

atcgtggatg aggtggcata tcacgagaag tacccaacca tctaccacct ccgcaaaaag      420

ctcgtggact ctaccgacaa ggccgacctc cgtctgatct acctcgcgct ggcccacatg      480

attaagttcc gaggacactt tctgatcgag ggcgacctga acccagacaa cagcgacgtg      540

gacaagctgt tcatccaact tgtccagacc tacaatcagc tcttcgagga gaaccctatc      600

aacgcctcgg gcgtggacgc gaaggccatc ctgtccgccc gcctgagcaa gtcgcggcgg      660

ctggagaacc tgatcgccca gctccccggc gaaaaaaaga acggcctctt cggcaacctc      720

atcgcgttgt cgctggggct caccccgaac ttcaagtcca acttcgacct ggccgaggac      780

gctaaactcc agctctcgaa ggatacctac gacgacgacc tcgacaacct gctggcccag      840

atcggcgacc agtacgcgga ccttttcctg gcggccaaga acctgagcga cgcgatcctc      900

cttagcgaca tactccgtgt gaacaccgag atcacgaagg ccccgctctc cgcgtccatg      960

attaagcgct acgacgagca ccaccaagac cttaccctgc ttaaggcgct ggtcaggcag     1020

cagttaccgg agaagtacaa ggagatcttt tttgatcaat ctaagaacgg ttacgccggg     1080

tacatcgacg gcggcgcgtc ccaggaggag ttctacaagt tcatcaagcc gatcttggag     1140

aaaatggacg ggaccgagga gctgctcgtg aagctcaacc gcgaagacct cctccgcaag     1200

cagcgcacct tcgacaacgg gagcatcccg caccagatcc acctgggaga gctgcacgcg     1260

atcctgcgga gacaagagga cttctacccc ttcctcaagg acaaccggga gaagattgaa     1320

aaaatactta cttttcgtat cccgtactac gtcgggcccc ttgcgagggg caactccaga     1380

ttcgcgtgga tgacccgcaa gtccgaggag accatcaccc cgtggaactt cgaggaggtg     1440

gtggacaagg gcgcgtcggc ccagtcgttc atcgagcgca tgaccaactt cgacaagaac     1500

cttccgaacg agaaggtgct cccgaagcac agcctgctct acgaatattt tactgtgtac     1560

aacgagctga cgaaggtcaa gtacgttacg gaggggatga ggaagcccgc cttcctctcc     1620

ggcgagcaga agaaagccat tgtggatctc ctgttcaaga ccaaccgcaa ggtgacggtg     1680

aaacagctca aagaggacta cttcaagaag atcgagtgct tcgactccgt agagatcagc     1740

ggggtcgagg accgcttcaa cgcctcgctg ggcacgtacc acgacctgct aaagattatc     1800

aaggacaaag acttcctaga caatgaggag aacgaggaca ttctggagga catcgtgctg     1860

actctgacgc tgttcgaaga ccgcgagatg atcgaggagc ggcttaagac gtacgcccac     1920

ctgttcgacg acaaggtgat gaagcagttg aaacggcggc gctacaccgg gtggggccgc     1980

ctctcccgca agctcatcaa cggcatccgc gacaagcagt cggggaagac gatcctggac     2040

ttcctcaaga gcgacggctt cgccaaccga aacttcatgc agctaatcca cgacgacagc     2100

ctgacgttca aggaggacat ccagaaggcc caagtgagcg gccagggaga ctcgctacac     2160

gagcatatcg ccaacctggc tggcagcccg gcgattaaga aaggaatcct ccaaaccgtc     2220

aaagtggtgg acgagctggt gaaggtgatg ggccgccaca agcccgagaa cattgtgatc     2280

gagatggcgc gggagaacca gacgacgcag aagggccaaa aaaatagcag ggaaaggatg     2340

aagcgaatag aggaggggat caaggagctg gggagccaga ttctcaaaga gcacccggtc     2400

gagaacacac agctccagaa cgagaagctg tacctctact acctccaaaa cggccgcgat     2460

atgtacgtgg accaggaact agacatcaac cggctgagcg actatgacgt ggaccacatc     2520

gtgccgcagt ccttcctcaa ggacgactcg attgacaaca aagtgctcac tagatccgac     2580

aagaacagag gcaagagcga taacgtcccg tcggaggagg tcgtcaagaa aatgaaaaac     2640

tactggcggc agctcctaaa cgccaagctc atcacgcagc gtaagttcga caacctgacg     2700

aaggcggagc ggggcgggct gagcgagctg gacaaagcgg ggttcatcaa gcggcagctc     2760

gttgagacgc ggcagatcac aaagcacgtc gcgcaaatcc tcgactcccg catgaacacc     2820

aagtacgacg agaacgacaa gctcatccgg gaggtgaagg tcattaccct taaatcgaag     2880

ctcgtcagcg actttcgtaa ggacttccag ttctacaagg tcagagagat caacaactac     2940

caccacgccc acgacgccta tctgaacgcc gtggtgggca ccgcgcttat taagaagtac     3000

cccaagctgg agtccgagtt cgtgtacggc gactacaagg tttatgacgt caggaagatg     3060

atcgccaagt cggaacagga gatcggaaaa gctaccgcca aatatttctt ctatagcaac     3120

atcatgaact tcttcaaaac cgagatcacc ctcgccaacg gcgagatccg gaagcgcccg     3180

ctcatcgaga ccaacgggga gaccggggag atcgtctggg acaaggggcg ggacttcgct     3240

actgtccgaa aggtgctctc catgccacaa gtgaatatcg tcaagaaaac agaggtgcag     3300

accggagggt tcagtaagga gtccatcctg cccaagcgga actccgacaa gctaattgct     3360

cgcaaaaagg attgggatcc taaaaaatat ggcggcttcg actcgcccac ggtcgcctac     3420

tctgtgctgg tcgtggcgaa ggtggagaag ggcaagtcca agaagctcaa gagcgtcaag     3480

gagctgctgg ggatcacgat catggagcgt agttcgtttg agaagaatcc catcgacttc     3540

ctggaggcta agggctacaa ggaggtcaaa aaggacctca tcattaagct gccgaagtac     3600

agcctcttcg agctggagaa cgggcggaag cgtatgctcg cctccgctgg ggagttacaa     3660

aaggggaacg agctggcgct gccgtctaag tacgtcaact tcctgtacct ggcctcccac     3720

tacgagaagc tcaaggggtc gccggaggac aacgagcaga agcagctctt cgtagagcag     3780

cacaagcact acctggacga gatcatcgag cagatttcag agttctcaaa gcgggtcatc     3840

ctcgccgacg ccaacctgga caaggtgctc tcggcctaca acaagcaccg ggacaagccg     3900

atccgcgaac aggccgaaaa catcatccac ctgttcacgc tcaccaacct cggtgccccg     3960

gcggccttca agtactttga cacgaccatc gaccggaagc gctatacctc gacgaaggag     4020

gtgctggacg ccaccctgat ccaccagtcc atcaccgggc tttacgagac ccggatcgac     4080

ctctcgcagc ta                                                         4092


<210>  114
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  114
gacaagaagt atagtattgg actcgccatc ggaaccaact ctgtggggtg ggctgttatt       60

acagatgaat ataaggtgcc atccaaaaag tttaaagttc tgggcaatac tgatagacac      120

tcaatcaaga agaatctgat aggtgcactt ctgtttgata gtggagagac tgccgaggca      180

accagactta aaaggactgc aagaagaaga tataccagaa gaaagaatag gatttgctat      240

ttgcaggaaa tcttcagcaa cgaaatggcc aaggttgatg actcattttt ccataggttg      300

gaggagagtt ttcttgtgga ggaagataag aagcacgaaa gacacccaat tttcgggaat      360

atagtggacg aggtggctta tcatgagaag tatcccacta tctaccacct gagaaagaaa      420

cttgtggact caaccgataa ggctgatctt aggcttatat acttggccct tgcacatatg      480

atcaaattca ggggccattt tcttatcgaa ggcgatctta atcccgataa ctcagatgtg      540

gacaagctgt ttatacaact tgtgcaaacc tacaatcaac tcttcgagga gaatcccatt      600

aacgcctccg gcgtggatgc aaaagccata ctgtcagcca gactgagcaa aagtaggaga      660

ctggagaatc ttatagccca actgcccggt gaaaagaaga atgggctctt cggaaatctg      720

atcgctcttt cattggggtt gacacccaac tttaagagta actttgactt ggcagaagat      780

gcaaagttgc agctcagtaa agacacatat gacgatgacc ttgacaatct cttggcacaa      840

ataggggatc aatacgctga ccttttcctc gctgccaaga acctcagcga cgctatactg      900

ttgtccgaca ttcttagggt taataccgaa attacaaagg cccctcttag tgcaagtatg      960

atcaaaaggt atgatgagca tcaccaagac cttacactgc tgaaggctct ggttagacag     1020

caactccctg aaaagtataa ggaaatattc ttcgaccaaa gtaagaacgg gtacgccggt     1080

tatattgatg ggggcgcaag tcaagaagaa ttttacaaat tcatcaagcc aattcttgaa     1140

aagatggacg ggactgagga attgctggtg aaactgaata gagaggacct tcttagaaaa     1200

cagaggacat ttgacaatgg gtccatccca caccagattc atctggggga actccacgca     1260

atattgagga gacaagaaga cttttaccca ttccttaagg ataatagaga gaaaatcgaa     1320

aaaatcctga ctttcaggat tccttactat gttgggccac tggccagggg gaactcaaga     1380

ttcgcttgga tgacaaggaa gtcagaagaa accataaccc cttggaattt tgaagaggtg     1440

gttgataagg gggcatcagc ccagtctttc atagagagga tgaccaactt tgataaaaat     1500

cttccaaatg agaaggtttt gccaaaacat agtcttttgt acgagtactt tactgtttat     1560

aacgaattga ccaaggtgaa gtatgtgacc gagggaatga ggaagccagc atttttgtcc     1620

ggggagcaaa agaaagcaat cgttgatctt ctcttcaaga ccaacagaaa agtgaccgtg     1680

aaacaactga aggaagacta cttcaaaaag atagaatgtt tcgattcagt ggaaattagc     1740

ggtgttgaag acaggttcaa tgcttcattg ggtacttacc acgacctgtt gaagataatc     1800

aaagacaagg actttctcga taatgaggag aacgaagaca tcttggaaga cattgtgctt     1860

acactcactt tgtttgagga cagggaaatg attgaggaaa gactcaaaac ttacgctcat     1920

ttgtttgatg ataaggttat gaaacaacta aaaagaagaa ggtacaccgg ctggggaaga     1980

ttgagtagga aactgatcaa cggtattaga gataaacaat ccggaaagac tatcctcgat     2040

ttccttaaga gtgatggctt tgcaaatagg aattttatgc agctgattca tgacgactca     2100

cttaccttca aagaagacat ccaaaaagct caggtgtctg ggcaaggcga cagtctgcat     2160

gaacatatag ctaacttggc tgggagtccc gccatcaaga aggggatact tcaaacagtt     2220

aaagttgtgg acgaattggt gaaggtaatg ggaaggcaca agcctgaaaa tatagtgata     2280

gaaatggcaa gggaaaatca aacaacccag aagggacaga agaacagtag ggaaaggatg     2340

aaaaggatag aagaggggat caaagagctt ggtagccaga tcctcaagga acatccagtg     2400

gagaataccc aacttcaaaa cgagaaactc tatttgtact acttgcagaa cggaagagat     2460

atgtatgtgg accaagagct tgatattaac aggctgagcg attatgacgt tgaccacata     2520

gtgccccaat cattcctcaa ggatgactct attgataata aggtgctgac aaggagtgac     2580

aagaatagag ggaaatccga caacgttcca tccgaggaag ttgtgaagaa gatgaagaac     2640

tactggaggc agttgctgaa cgctaagctc attacccaga ggaaattcga taacctgacc     2700

aaagcagaga gaggcgggct gagcgaactc gataaagcag gtttcatcaa gagacaactc     2760

gtggagacta ggcaaattac taagcacgtg gctcaaatac tcgacagcag gatgaacaca     2820

aagtacgacg agaacgacaa gctcattaga gaggttaagg ttattactct gaaaagtaaa     2880

ttggttagcg atttcagaaa ggatttccaa ttctataagg ttagagagat caacaattat     2940

catcatgcac atgatgccta tctgaatgct gtggttggta cagcccttat caagaagtac     3000

cctaagctag agagcgagtt tgtgtacgga gattataagg tgtatgatgt gaggaaaatg     3060

atcgctaaaa gtgagcaaga gattggaaag gctaccgcca aatacttctt ttattccaat     3120

attatgaatt tcttcaagac agaaatcacc ctggctaacg gcgagataag gaagaggccg     3180

cttatcgaaa ctaatgggga gacaggcgaa atagtgtggg acaaagggag ggatttcgca     3240

actgtgagga aggttttgag catgcctcag gtgaatatcg ttaagaaaac cgaagttcaa     3300

actggagggt tctctaagga aagcattctc cccaagagga actccgacaa gctgattgct     3360

agaaagaaag actgggaccc caagaagtat ggcggattcg actcacccac tgtggcatat     3420

agcgttctcg tggtggcaaa ggttgaaaag ggtaaatcca aaaaactcaa atccgtgaag     3480

gaactccttg gcataactat tatggaaagg agtagctttg aaaagaatcc catcgacttt     3540

ctcgaagcta agggctataa ggaagttaag aaggacctta taatcaaact tccaaaatac     3600

tccctttttg agttggaaaa cggcagaaag agaatgttgg ccagtgccgg ggagcttcaa     3660

aagggcaacg aactggctct gcctagcaaa tatgtgaact ttttgtatct ggcatcacac     3720

tacgagaaac ttaaaggctc tcctgaggac aacgagcaaa aacagctctt tgttgaacag     3780

cataagcact acctcgacga gattattgag cagatcagcg agttctcaaa gagagttatt     3840

ctggctgacg ctaatcttga caaggttttg tccgcttaca acaaacacag ggataagcca     3900

atcagggagc aggcagaaaa cataatccat ctctttaccc tgacaaacct cggtgccccc     3960

gctgctttca agtattttga tactaccatt gacaggaaga gatatacttc cactaaggaa     4020

gtgctcgacg caaccctcat acaccaaagt atcacaggcc tctatgaaac taggatagat     4080

ttgtctcaac ttgggggcga t                                               4101


<210>  115
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  115
gacaaaaagt attccatcgg gcttgctatc ggaaccaact ctgtggggtg ggcagttatt       60

accgacgaat acaaggtgcc cagcaagaag tttaaggttc tggggaacac agatagacat      120

agcataaaga aaaacctgat aggcgcactg ttgttcgact ccggggaaac agccgaagct      180

accaggctga agagaactgc aagaagaagg tacaccagaa gaaaaaacag aatatgttat      240

ctccaagaga ttttctctaa cgagatggcc aaggtggacg actcattctt tcacagactg      300

gaagaatctt tccttgtgga agaagataag aaacacgaga ggcaccctat ttttggcaat      360

atcgtggatg aggtggctta ccacgaaaaa taccctacaa tataccacct caggaaaaaa      420

ttggttgata gtacagacaa ggccgacctc aggctcatct atttggccct ggcccatatg      480

attaaattca gggggcactt tctcatcgag ggagatttga accccgacaa cagtgatgtt      540

gataagctct ttattcagct cgtgcagact tacaatcagt tgtttgagga aaaccccatt      600

aatgcttccg gggtggacgc caaggcaatc ctttctgcaa gactctcaaa gtcaaggaga      660

ctcgaaaatc tgatagcaca gcttccagga gagaagaaga acgggctctt tggaaacctg      720

atcgctctgt cactcggact cacacccaat ttcaaaagca attttgattt ggcagaggac      780

gctaagctgc aactcagtaa ggatacctac gacgatgact tggataatct gctcgcacaa      840

attggggacc agtatgcaga cctgtttctc gcagctaaga acttgagtga cgccatattg      900

ctcagtgaca tcctcagggt taataccgag attacaaaag ctccactctc tgcaagcatg      960

atcaagaggt atgacgagca ccatcaagac ctgacactcc ttaaggcgtt ggttaggcag     1020

caacttcctg aaaagtataa ggaaatcttc ttcgatcaaa gcaaaaacgg ctacgccggc     1080

tatatagacg ggggagcatc ccaagaagaa ttttataagt tcataaaacc tatattggag     1140

aagatggacg ggacagagga attgctcgtg aaactgaaca gggaggatct cctcaggaag     1200

caaaggacct tcgacaatgg ctccatccca catcagattc acctcggcga actgcacgca     1260

atactgagaa gacaagagga cttttatcct ttcctgaagg acaacaggga gaaaatcgag     1320

aaaatcttga cattcagaat cccatactac gttgggcctc tggccagagg taacagtagg     1380

ttcgcctgga tgactaggaa atcagaggag actattacac cctggaactt tgaagaagtt     1440

gttgataagg gagcttcagc acaatcattc atcgaaagaa tgacaaactt tgacaaaaat     1500

ctgcctaatg agaaagtgct cccaaaacat tccctgctgt atgagtattt taccgtttat     1560

aacgagctta ccaaggtgaa atacgttact gaaggtatga gaaagccagc ttttctttca     1620

ggggagcaaa agaaggctat cgtggatctt ctctttaaga ccaacagaaa ggttaccgtg     1680

aagcagctta aggaagacta ctttaaaaag atcgagtgtt ttgactcagt ggaaataagc     1740

ggtgttgaag atagattcaa cgcatccttg ggaacttatc atgatcttct taagataatc     1800

aaggataaag actttctcga caacgaggaa aacgaagata tactggagga catagttctg     1860

acacttactt tgttcgagga tagggagatg atcgaggaaa gactgaaaac atatgctcac     1920

cttttcgacg acaaagttat gaaacaactc aagagaagga gatatacagg gtgggggaga     1980

ttgagcagga aactgattaa tggtatcaga gacaaacagt caggaaaaac aatactcgac     2040

tttttgaaat cagacgggtt cgcaaatagg aatttcatgc agcttataca cgacgattca     2100

cttactttta aagaggacat tcaaaaggct caagttagtg gacaaggtga ctccctccac     2160

gaacacatcg caaatctcgc tggcagccct gcaattaaga agggtatact ccagacagtt     2220

aaggttgttg acgagctggt taaagtgatg ggaagacaca aacccgagaa catagtgata     2280

gagatggcca gggaaaacca aaccactcaa aaagggcaga aaaattccag agagaggatg     2340

aaaaggattg aagaaggtat caaggagctg ggtagccaaa ttctgaaaga acatcctgtg     2400

gaaaacactc aactccagaa tgagaaactc tatctgtact atctgcaaaa tgggagagat     2460

atgtatgtgg accaggaact ggacataaac aggctctcag attacgatgt ggatcatatc     2520

gtgccacagt cctttcttaa ggatgatagc atcgacaata aggtgcttac caggtccgac     2580

aagaacaggg gaaagtcaga taacgtgcct tctgaagaag ttgttaaaaa gatgaagaac     2640

tactggagac agctgcttaa cgctaagctc ataacacaga ggaagtttga caacttgacc     2700

aaggccgaga gaggcggact ctcagaattg gataaggcag ggttcataaa aaggcagctg     2760

gtggaaacaa ggcagataac taaacatgtg gctcagatcc tcgatagtag gatgaataca     2820

aaatacgatg agaacgacaa gctcataagg gaggttaaag tgataactct gaaatccaaa     2880

ctggttagcg attttaggaa ggatttccag ttttacaaag ttagggagat caacaattat     2940

catcacgccc acgatgccta cttgaacgca gttgtgggta ctgcacttat caaaaagtac     3000

cctaagctgg aatccgagtt tgtttatgga gactataagg tgtacgacgt tagaaaaatg     3060

attgcaaagt cagagcagga gatagggaaa gccactgcaa aatatttctt ttatagcaat     3120

atcatgaatt tctttaagac agaaatcaca ctggccaatg gggaaataag gaagaggccc     3180

ctgatcgaaa ctaatggcga gacaggggag attgtgtggg ataaaggtag ggactttgca     3240

acagtgagga aagtgctgag catgccccaa gttaatatcg ttaaaaagac cgaggttcaa     3300

acagggggct ttagtaagga aagcattttg cccaagagga atagtgacaa attgattgct     3360

aggaaaaaag attgggaccc caaaaagtat ggcggatttg atagccccac tgttgcttac     3420

tccgtgctcg tggttgcaaa ggtggagaag ggaaagagca agaaactgaa gtcagttaag     3480

gaactccttg gtatcactat catggaaaga agctcctttg agaagaaccc tattgacttc     3540

ctggaggcta aagggtacaa agaggttaag aaagacctta tcattaaatt gcccaaatat     3600

agtcttttcg agcttgaaaa cggaagaaag aggatgcttg catccgctgg cgaattgcaa     3660

aagggcaatg agcttgctct cccttccaag tatgtgaact tcctttatct tgcctcacac     3720

tatgaaaaac tcaaaggttc acccgaagac aacgaacaaa agcaactatt tgtggaacaa     3780

cacaagcact acctggacga aatcattgag caaatttctg agttttcaaa aagggtaatc     3840

ttggctgacg caaatctcga caaagttttg tcagcttaca acaaacatag agataagcca     3900

attagagagc aagctgagaa tatcatccat ctgtttaccc tgactaacct tggagcgcct     3960

gctgctttta aatatttcga caccacaatc gacaggaaga ggtacactag cactaaggaa     4020

gttctcgacg ccaccctcat ccaccagagt attacaggcc tgtacgagac aagaattgat     4080

ctttctcaac ttggtggtga c                                               4101


<210>  116
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  116
gataagaagt actcaatcgg tctggcaatc ggaaccaact ctgtgggttg ggcagtgatt       60

acagatgagt ataaggtgcc aagcaaaaaa ttcaaggtgc tgggtaatac cgacagacac      120

agcattaaga agaatttgat tggagcactc ctctttgact caggggaaac agcagaggca      180

acaaggctga agaggacagc aaggcggagg tacacaaggc ggaaaaacag gatatgctac      240

ctccaggaaa tctttagcaa cgagatggct aaagtggatg atagcttttt ccatagactc      300

gaagaatcct ttcttgttga agaggacaaa aagcatgaaa ggcatcccat cttcggcaat      360

atagttgatg aggttgcata ccatgagaag taccccacaa tctaccacct cagaaagaaa      420

cttgtggact ccacagataa agcagacctg aggctcatat acctcgcact cgcacacatg      480

atcaagttca gagggcactt tctcatcgaa ggtgacctga atccagataa ttcagatgtg      540

gataaactgt ttatacagct ggtgcaaaca tacaaccaac ttttcgagga aaacccaatc      600

aatgcctccg gtgttgatgc aaaggccatc ctgtcagcaa gactcagcaa aagcaggcgg      660

ctcgaaaacc tcatcgccca gcttcccggt gaaaagaaga acgggctctt tggtaatctc      720

atcgcattga gccttggtct tactccaaac ttcaagagca attttgatct ggcagaggat      780

gctaaactgc aactctcaaa ggacacatat gacgatgacc ttgacaatct gttggcccag      840

atcggggacc aatatgcaga cctcttcctg gccgcaaaga atctgtcaga tgcaatcctc      900

ttgtccgaca tactgagagt taacactgag atcacaaagg cacctctgtc cgcctccatg      960

attaagagat acgatgagca tcaccaggat ctgactttgc tcaaagccct cgttagacag     1020

cagttgccag aaaagtacaa agaaatattc tttgatcaat caaaaaacgg atatgcaggg     1080

tacatcgacg gtggggcaag ccaggaagag ttctacaaat tcatcaaacc tatcctggaa     1140

aagatggatg ggacagaaga gctgctggtt aagctgaata gggaagacct cctcagaaag     1200

cagaggacat ttgataacgg gagcatccct catcaaatcc acctcggtga actccatgct     1260

atcctgagaa ggcaggaaga cttttatcca tttttgaagg acaataggga gaaaatcgaa     1320

aaaatcctga cattcagaat cccatactac gttggtcctc tggcaagagg taacagtagg     1380

ttcgcatgga tgacaaggaa aagcgaggag acaatcacac cctggaattt tgaggaagtt     1440

gttgacaagg gtgccagcgc acaatccttt atcgaaagaa tgacaaattt cgacaagaat     1500

ctgcctaacg aaaaggttct cccaaagcat tcactcctgt acgaatattt tacagtttat     1560

aacgaactga ctaaagttaa atacgttacc gagggtatga ggaagccagc attcctttcc     1620

ggggaacaga agaaagctat tgtggacctc ctgttcaaga caaatagaaa agtgacagtt     1680

aagcaactca aagaggatta cttcaaaaag atcgaatgtt ttgactctgt ggagatcagc     1740

ggggtggagg atagattcaa cgccagcctg ggtacatatc atgatctcct gaaaatcatt     1800

aaagacaagg acttccttga caacgaggag aacgaggaca ttctggaaga cattgttctg     1860

accctcacac tctttgagga tagggagatg attgaggaaa gactgaagac ctacgcccac     1920

ctctttgacg ataaagtgat gaaacagctc aagagaagaa ggtatacagg ttgggggaga     1980

ctgagcagga agttgatcaa tgggattagg gacaaacagt ccgggaaaac aatcctcgat     2040

tttctgaagt cagacggttt cgcaaacaga aattttatgc agctcattca cgatgacagc     2100

ttgacattca aggaagacat ccaaaaggct caagtgagcg gccaagggga tagcctccac     2160

gagcatattg caaatctggc aggttcacca gccatcaaaa agggcatact tcagacagtt     2220

aaggttgtgg acgaattggt taaagttatg ggcaggcata agccagagaa tatcgttatc     2280

gaaatggcaa gggagaacca aacaactcaa aaagggcaga aaaatagcag agagaggatg     2340

aaaagaatcg aggaagggat caaggaactt gggtcccaaa tcctcaagga gcacccagtt     2400

gaaaatactc aactgcaaaa cgagaagctc tatctctact atctccaaaa cgggagggat     2460

atgtatgttg accaggagct ggatattaac agactgtcag attatgatgt tgatcatatc     2520

gtgccccagt cattcctgaa ggacgattcc atcgacaaca aagttctcac aaggtccgat     2580

aaaaacaggg gcaagtccga taacgttcca agcgaagaag tggtgaaaaa gatgaaaaac     2640

tattggagac aacttctgaa tgcaaagttg attactcaga gaaagtttga caacctcaca     2700

aaagcagaaa gaggcgggct tagcgaactc gataaggcag ggtttatcaa aagacagctg     2760

gttgagacaa ggcagatcac aaaacatgtg gcacagatcc ttgactcaag gatgaatacc     2820

aagtatgatg agaatgataa gttgatcagg gaggttaaag ttatcacact caaatccaaa     2880

ctggtgtcag acttcaggaa agactttcaa ttttataagg tgagggagat caataactac     2940

caccatgcac atgacgccta cctgaacgca gtggtgggta cagcattgat taaaaaatac     3000

cctaagctgg agtctgagtt tgtgtacggg gactacaagg tgtacgacgt gaggaaaatg     3060

atagccaagt ccgagcagga gatcgggaaa gcaacagcta agtatttctt ttacagtaat     3120

atcatgaatt tctttaaaac tgagattact ctggcaaacg gggagatcag gaaaagaccc     3180

ctcatcgaga ctaatggtga aacaggtgag atcgtttggg acaaggggag ggattttgct     3240

actgttagaa aagttctgag tatgccacaa gtgaatattg tgaaaaagac agaagttcag     3300

acaggtgggt tctccaaaga atccatcctg cccaagagaa attcagacaa gctcatcgca     3360

agaaagaagg actgggaccc taagaagtac ggaggatttg acagccccac cgtggcctat     3420

tccgtgcttg ttgtggcaaa ggtggagaaa gggaagagca aaaaactgaa atccgtgaaa     3480

gaactgctgg gaattaccat catggaaaga agctcctttg agaagaaccc aatcgacttc     3540

ctggaagcaa aaggatataa ggaagtgaaa aaggacctca ttatcaagct cccaaaatac     3600

tcacttttcg agttggagaa cggtagaaag aggatgctgg caagcgcagg ggaacttcag     3660

aaaggcaatg agctggcatt gccatcaaag tatgtgaact tcctctactt ggccagccat     3720

tacgagaaac ttaaaggtag cccagaagat aacgagcaaa aacagctctt tgtggaacag     3780

cataagcatt atctggatga gatcatagaa caaatctcag agttttccaa gagagttatc     3840

ctcgcagatg caaacctgga taaggttctc tcagcctata ataagcatag agacaagcca     3900

attagagagc aagcagagaa cattatccac ttgttcactc ttacaaacct gggggcacca     3960

gccgccttca aatatttcga tacaacaata gacagaaaga ggtataccag caccaaagaa     4020

gttctcgacg ccacactgat ccatcaatca atcacaggcc tttacgaaac taggatcgac     4080

ttgtcacaac tgggtgggga t                                               4101


<210>  117
<211>  3307
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  117
gagcaaggac acctacgacg acgacttgga caacctattg gcccagatag gtgaccagta       60

tgcagacctc ttccttgcgg ccaagaactt gagtgacgct atactgctca gtgacatcct      120

gagggtgaac actgagatca ctaaggcccc tctctctgcc tcaatgatta agcgttacga      180

cgagcatcac caggatctca ccctgcttaa ggcccttgtt cggcagcagc tccctgagaa      240

gtacaaggag atattttttg accagtctaa gaacggctac gccggttaca ttgacggtgg      300

ggcaagccag gaggagttct acaagttcat caagccgatc cttgagaaga tggacggcac      360

cgaggagcta cttgtcaagt tgaaccggga agacctgctc cggaaacagc gtacattcga      420

caacggcagc atccctcacc agatccacct gggcgaacta cacgccatcc tccgacgtca      480

ggaggacttc tatccattct tgaaagataa cagggaaaaa atcgaaaaaa tacttacgtt      540

tcgaatacct tactacgtgg ggccccttgc tcggggaaac tccagattcg catggatgac      600

caggaagtca gaggagacca tcacaccctg gaactttgag gaggtggttg acaaaggtgc      660

ttctgcccag tccttcattg agcggatgac taacttcgac aagaacctgc ccaacgagaa      720

ggtgctgcca aagcacagcc tgctctacga atactttact gtgtacaatg agctgacgaa      780

ggtgaagtac gtgacagagg ggatgcggaa gcccgctttc ctgagcggcg agcaaaaaaa      840

agcaatcgtg gacctactgt tcaagaccaa ccgaaaggtg acagtgaagc agctcaagga      900

ggactacttc aaaaaaatcg agtgcttcga ctctgttgag ataagcggcg tggaggaccg      960

attcaacgcc tcattgggaa cctatcacga cctgctcaag atcattaagg acaaggactt     1020

cctggataat gaggagaatg aggacatcct ggaggatatt gtgctgaccc ttactctatt     1080

cgaggacagg gagatgatcg aggagcgact caagacctac gctcacctgt tcgacgacaa     1140

ggttatgaag caattgaagc gtaggcgata cacggggtgg ggaagactct cccgaaaact     1200

gataaacggc atcagggaca agcagtcagg gaagacgatc ttggacttcc tgaaatccga     1260

cgggttcgcc aaccgcaact tcatgcagct cattcacgac gactcactaa cgttcaaaga     1320

ggacattcag aaggctcaag tcagtggaca aggcgactcc ctgcacgagc acattgcaaa     1380

ccttgcgggc tccccggcga ttaaaaaggg cattctccaa acggttaagg tggtggacga     1440

gctggtgaag gtgatgggcc gacacaagcc tgagaacatc gtgatcgaga tggccaggga     1500

gaaccagact acccagaagg gtcagaagaa ctctcgggaa cgtatgaagc gtattgagga     1560

ggggattaag gagttgggct ctcaaatcct caaggagcac cctgtggaga acactcagct     1620

ccaaaacgag aagctgtacc tgtactacct gcaaaacggg cgcgatatgt acgtggatca     1680

ggagttggac atcaacaggc ttagcgatta cgacgtggac cacatcgtgc cacagtcatt     1740

cttaaaggac gacagcatcg acaacaaggt tctgacgagg agcgacaaga atcgagggaa     1800

aagtgacaat gttccatccg aggaggtggt caagaaaatg aagaactatt ggcgtcagct     1860

tctgaacgcc aagctcatca cccagcggaa attcgacaac ctgactaagg ctgagcgagg     1920

cggactctcc gagcttgaca aggctggctt catcaagcgg cagttggtcg aaacccgaca     1980

gataacgaag cacgttgccc agatacttga ctcccgtatg aacaccaagt acgacgagaa     2040

cgacaagctc atcagggagg tgaaggtcat tacccttaag tccaaactcg tcagcgactt     2100

tcgtaaggac ttccagttct acaaggtgcg cgagatcaat aactaccacc acgcacacga     2160

cgcctacctg aacgcagtgg ttggaaccgc gttgattaaa aagtacccca agttggagtc     2220

ggagttcgtt tacggggact acaaggtgta cgacgttcgg aagatgatcg ccaagtctga     2280

acaggagatc gggaaagcaa ccgccaagta tttcttctat agcaacatca tgaacttctt     2340

taaaaccgag atcacacttg ccaatggcga gatccgtaag aggccgctga tcgagacaaa     2400

tggggagact ggcgagatcg tgtgggacaa gggccgcgac ttcgcaaccg ttcggaaagt     2460

cttgtccatg cctcaagtca acatcgtcaa gaagactgag gtgcaaacag gcgggttctc     2520

gaaggagtcc atactgccca agaggaactc agacaagctc atagcacgca aaaaagactg     2580

ggatccaaag aaatacggcg ggttcgactc gccgacagtc gcatactccg tgttagtggt     2640

ggctaaagtg gaaaagggga agtccaagaa gctcaagtcc gtcaaggagt tgctcgggat     2700

caccattatg gaacggtcct cattcgagaa gaatcccatt gacttcctag aggcgaaggg     2760

ctacaaagag gtcaaaaagg acctaattat taagctcccc aagtattcac tcttcgaact     2820

tgaaaatggt cgtaagcgga tgttggcaag cgctggagag cttcagaagg ggaacgagct     2880

tgcactgcct tccaagtacg tgaacttcct gtacctcgcc tctcattacg agaagttgaa     2940

gggctcaccg gaggacaacg agcagaagca gttgttcgtg gagcagcaca agcactacct     3000

cgacgagatc attgagcaga taagtgagtt cagcaaacgg gtgatccttg ccgacgctaa     3060

cctggacaag gtgctgagcg cctacaacaa gcacagagac aagccgatcc gagagcaagc     3120

ggagaacatc atacacctgt tcaccctcac gaacctcggg gctcccgcag ccttcaaata     3180

ttttgacacg accatcgacc gtaaacgcta cactagcacg aaggaggtgc tggacgctac     3240

ccttatccac cagtccatca ccggcctgta cgagacgaga atcgacttgt cgcagctcgg     3300

tggtgac                                                               3307


<210>  118
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  118
gacaaaaaat actcaattgg tctggcaatt gggaccaaca gtgtcggatg ggccgtgatt       60

accgacgagt acaaggtgcc gtccaaaaaa ttcaaggtgc ttgggaacac cgaccgccac      120

tcgatcaaga aaaacctaat cggtgcgttg cttttcgaca gtggggagac cgccgaggca      180

acacgcttaa aacgcacagc taggaggaga tatacacggc gcaagaaccg aatatgctac      240

ttacaggaga tattctccaa tgagatggcg aaggtggacg actctttctt ccatcggctt      300

gaggaatcct tcctggtcga ggaggacaag aagcacgagc gacacccgat attcgggaac      360

atcgttgatg aggtggcgta ccacgagaag tacccaacga tataccactt acgcaagaag      420

ctcgtggact ctacggacaa ggccgacttg cgccttatct acttggcact ggcccacatg      480

attaagttcc gaggccactt ccttatcgag ggtgacctga accccgataa ctccgacgtg      540

gacaagctct tcatccaact cgtccagaca tacaaccagc tattcgagga gaatcctatc      600

aacgcctctg gggtggacgc taaagctatc ctctcagccc gcctgtcaaa gtcgaggagg      660

ttggagaacc taatcgccca gcttccaggc gagaagaaaa atgggctgtt cggaaacctt      720

atcgcactct cactgggcct aaccccgaac ttcaagtcca acttcgacct ggcagaggac      780

gcgaaattgc agttgtcgaa agacacctat gacgatgacc tggacaacct gttggcccag      840

ataggggacc agtacgccga cctgttccta gcggccaaga acctgtccga cgccatcttg      900

ctgtcggata tactgcgggt gaacaccgag atcactaaag cacctctctc cgccagcatg      960

attaagcgtt acgacgagca ccaccaagat ttgaccctgc taaaggcact tgtacggcag     1020

cagcttcccg agaagtacaa ggagatcttt ttcgaccaaa gcaagaacgg ctacgccggg     1080

tacatcgacg gaggtgccag ccaggaggag ttctacaagt tcattaagcc catcctggag     1140

aagatggacg ggactgagga actacttgtg aagctgaacc gggaagactt actacggaag     1200

cagcgtacct tcgacaacgg ttctatccca catcagatcc atcttgggga gttgcacgcg     1260

atcctgcgac gccaggagga cttttacccc ttcctgaaag acaaccgcga gaaaatcgag     1320

aagatactga ccttcagaat accttactac gtcggacccc ttgcgcgagg caactcaaga     1380

ttcgcgtgga tgaccaggaa atcagaggag accatcacac cctggaattt cgaggaggtg     1440

gttgacaagg gtgcctccgc ccagtccttt atcgaacgaa tgaccaactt cgacaagaac     1500

ttgcccaacg agaaggtgct ccccaaacac agcctcctct acgaatattt cacagtgtac     1560

aacgagctta ctaaagttaa gtatgttact gagggcatga ggaaacccgc cttcctgtca     1620

ggcgagcaga agaaagctat tgtggacctc cttttcaaga ccaaccggaa ggtgacagtg     1680

aagcagctca aggaggacta cttcaagaag atagagtgct tcgacagcgt ggagatcagc     1740

ggggtggagg acagattcaa tgcctctctc ggaacatacc acgacttgct taagatcatc     1800

aaggacaagg acttcctcga caacgaggaa aacgaggata ttctggagga tattgttctg     1860

actcttaccc tgttcgagga ccgggagatg atcgaggagc gtctcaagac ctacgcccac     1920

ctgttcgacg acaaagttat gaagcagctc aagcgtcgga gatataccgg atggggccgt     1980

ctgtctcgga agctcatcaa cgggatcagg gacaagcagt cagggaagac gatcttagac     2040

ttccttaagt ctgacggctt cgccaacagg aacttcatgc agttgatcca cgacgacagc     2100

cttaccttca aggaggacat ccagaaggcc caagtgagtg gccagggtga cagcctccac     2160

gagcatattg ctaatcttgc gggttcccca gcgattaaaa agggcatact tcaaaccgtt     2220

aaggtggtgg acgagcttgt caaggtgatg gggcgacaca agcccgagaa catcgtgatc     2280

gagatggcca gggagaacca gaccacccag aaggggcaga agaatagccg agaacgcatg     2340

aagcgcatcg aggaggggat taaggagcta gggagccaga tcctcaagga acatcccgtc     2400

gagaacaccc agctccagaa cgagaagcta tacctctact acttgcaaaa cgggagggat     2460

atgtacgtgg atcaggagtt ggacattaac cgcctaagcg actacgacgt agatcacatc     2520

gtgcctcagt cattcctcaa agacgacagc attgacaaca aagtcttgac ccgatccgac     2580

aagaaccgag gaaaatccga caatgtgccc tcagaggagg tcgtcaagaa aatgaagaac     2640

tattggaggc agctacttaa cgccaaactc ataacccagc ggaagttcga caacctgaca     2700

aaggctgagc ggggtgggct cagcgagctt gacaaggctg gcttcatcaa gcggcagttg     2760

gtggagacaa gacagataac gaagcacgtg gctcagatcc tggactctcg catgaacacg     2820

aagtacgacg agaacgacaa attgatccgc gaggtcaagg ttattacgct caagagcaaa     2880

cttgtcagcg atttccgcaa ggacttccag ttctacaagg tgagggagat taacaactac     2940

caccatgcac atgatgccta cttgaacgca gtggtgggga ccgcgcttat taaaaagtac     3000

cctaagttgg agtcagagtt cgtttatggg gactacaagg tgtacgacgt ccggaagatg     3060

attgcaaagt ctgaacagga aatcgggaag gccaccgcca aatatttctt ctacagtaac     3120

attatgaatt tttttaagac tgaaattact ctcgcaaacg gcgagatcag gaagcgtccc     3180

ctcatcgaga caaacgggga gaccggggag atagtctggg acaaggggcg ggacttcgct     3240

acggtgagga aggtgctctc gatgccacaa gtgaacatcg tcaaaaagac agaggtgcag     3300

accggtggct tctcaaagga gtcaatcctg ccaaaacgta acagcgacaa gctcatcgcc     3360

cgcaagaaag actgggaccc taagaagtat ggtgggttcg actcaccgac ggtcgcatac     3420

tccgttctgg tcgtggcaaa ggtggaaaag ggcaagtcca aaaaactgaa atccgtgaag     3480

gagttgcttg gcattaccat catggaacgc agcagcttcg agaagaaccc cattgacttc     3540

ctggaggcta aagggtacaa ggaggtcaag aaagatttaa ttattaagct acctaagtac     3600

agcttgttcg agctggagaa cggccgaaaa cgaatgctcg catccgccgg ggaacttcaa     3660

aagggcaacg agcttgcgct gccctccaag tacgtgaact tcctgtactt ggcatcccac     3720

tacgagaaac tcaagggtag cccagaggac aacgagcaga agcagctatt cgtggagcag     3780

cacaagcact acctcgacga gataatcgag cagatcagtg agttcagtaa gcgggtgata     3840

ctcgcggacg ccaacttgga caaggtgctt agtgcctaca acaagcaccg tgacaagccc     3900

atccgagaac aggctgagaa catcatccac cttttcactc tgacaaacct cggtgctccc     3960

gccgccttca aatacttcga cactaccatc gacaggaagc gctacacatc tacgaaggaa     4020

gttcttgacg ctacgcttat tcatcagtct atcacagggc tgtacgagac aaggatcgac     4080

cttagccaac tcggcgggga t                                               4101


<210>  119
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic Cas9

<400>  119
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  120
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic eCas9

<400>  120
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctggc cgacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctgccctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaaggcccct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  121
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nCas9(D10A)

<400>  121
gacaagaagt acagcatcgg cctggccatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggaccatatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  122
<211>  4101
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic nCas9(H840A)

<400>  122
gacaagaagt acagcatcgg cctggacatc ggcaccaact ctgtgggctg ggccgtgatc       60

accgacgagt acaaggtgcc cagcaagaaa ttcaaggtgc tgggcaacac cgaccggcac      120

agcatcaaga agaacctgat cggagccctg ctgttcgaca gcggcgaaac agccgaggcc      180

acccggctga agagaaccgc cagaagaaga tacaccagac ggaagaaccg gatctgctat      240

ctgcaagaga tcttcagcaa cgagatggcc aaggtggacg acagcttctt ccacagactg      300

gaagagtcct tcctggtgga agaggataag aagcacgagc ggcaccccat cttcggcaac      360

atcgtggacg aggtggccta ccacgagaag taccccacca tctaccacct gagaaagaaa      420

ctggtggaca gcaccgacaa ggccgacctg cggctgatct atctggccct ggcccacatg      480

atcaagttcc ggggccactt cctgatcgag ggcgacctga accccgacaa cagcgacgtg      540

gacaagctgt tcatccagct ggtgcagacc tacaaccagc tgttcgagga aaaccccatc      600

aacgccagcg gcgtggacgc caaggccatc ctgtctgcca gactgagcaa gagcagacgg      660

ctggaaaatc tgatcgccca gctgcccggc gagaagaaga atggcctgtt cggaaacctg      720

attgccctga gcctgggcct gacccccaac ttcaagagca acttcgacct ggccgaggat      780

gccaaactgc agctgagcaa ggacacctac gacgacgacc tggacaacct gctggcccag      840

atcggcgacc agtacgccga cctgtttctg gccgccaaga acctgtccga cgccatcctg      900

ctgagcgaca tcctgagagt gaacaccgag atcaccaagg cccccctgag cgcctctatg      960

atcaagagat acgacgagca ccaccaggac ctgaccctgc tgaaagctct cgtgcggcag     1020

cagctgcctg agaagtacaa agagattttc ttcgaccaga gcaagaacgg ctacgccggc     1080

tacattgacg gcggagccag ccaggaagag ttctacaagt tcatcaagcc catcctggaa     1140

aagatggacg gcaccgagga actgctcgtg aagctgaaca gagaggacct gctgcggaag     1200

cagcggacct tcgacaacgg cagcatcccc caccagatcc acctgggaga gctgcacgcc     1260

attctgcggc ggcaggaaga tttttaccca ttcctgaagg acaaccggga aaagatcgag     1320

aagatcctga ccttccgcat cccctactac gtgggccctc tggccagggg aaacagcaga     1380

ttcgcctgga tgaccagaaa gagcgaggaa accatcaccc cctggaactt cgaggaagtg     1440

gtggacaagg gcgcttccgc ccagagcttc atcgagcgga tgaccaactt cgataagaac     1500

ctgcccaacg agaaggtgct gcccaagcac agcctgctgt acgagtactt caccgtgtat     1560

aacgagctga ccaaagtgaa atacgtgacc gagggaatga gaaagcccgc cttcctgagc     1620

ggcgagcaga aaaaggccat cgtggacctg ctgttcaaga ccaaccggaa agtgaccgtg     1680

aagcagctga aagaggacta cttcaagaaa atcgagtgct tcgactccgt ggaaatctcc     1740

ggcgtggaag atcggttcaa cgcctccctg ggcacatacc acgatctgct gaaaattatc     1800

aaggacaagg acttcctgga caatgaggaa aacgaggaca ttctggaaga tatcgtgctg     1860

accctgacac tgtttgagga cagagagatg atcgaggaac ggctgaaaac ctatgcccac     1920

ctgttcgacg acaaagtgat gaagcagctg aagcggcgga gatacaccgg ctggggcagg     1980

ctgagccgga agctgatcaa cggcatccgg gacaagcagt ccggcaagac aatcctggat     2040

ttcctgaagt ccgacggctt cgccaacaga aacttcatgc agctgatcca cgacgacagc     2100

ctgaccttta aagaggacat ccagaaagcc caggtgtccg gccagggcga tagcctgcac     2160

gagcacattg ccaatctggc cggcagcccc gccattaaga agggcatcct gcagacagtg     2220

aaggtggtgg acgagctcgt gaaagtgatg ggccggcaca agcccgagaa catcgtgatc     2280

gaaatggcca gagagaacca gaccacccag aagggacaga agaacagccg cgagagaatg     2340

aagcggatcg aagagggcat caaagagctg ggcagccaga tcctgaaaga acaccccgtg     2400

gaaaacaccc agctgcagaa cgagaagctg tacctgtact acctgcagaa tgggcgggat     2460

atgtacgtgg accaggaact ggacatcaac cggctgtccg actacgatgt ggacgccatc     2520

gtgcctcaga gctttctgaa ggacgactcc atcgacaaca aggtgctgac cagaagcgac     2580

aagaaccggg gcaagagcga caacgtgccc tccgaagagg tcgtgaagaa gatgaagaac     2640

tactggcggc agctgctgaa cgccaagctg attacccaga gaaagttcga caatctgacc     2700

aaggccgaga gaggcggcct gagcgaactg gataaggccg gcttcatcaa gagacagctg     2760

gtggaaaccc ggcagatcac aaagcacgtg gcacagatcc tggactcccg gatgaacact     2820

aagtacgacg agaatgacaa gctgatccgg gaagtgaaag tgatcaccct gaagtccaag     2880

ctggtgtccg atttccggaa ggatttccag ttttacaaag tgcgcgagat caacaactac     2940

caccacgccc acgacgccta cctgaacgcc gtcgtgggaa ccgccctgat caaaaagtac     3000

cctaagctgg aaagcgagtt cgtgtacggc gactacaagg tgtacgacgt gcggaagatg     3060

atcgccaaga gcgagcagga aatcggcaag gctaccgcca agtacttctt ctacagcaac     3120

atcatgaact ttttcaagac cgagattacc ctggccaacg gcgagatccg gaagcggcct     3180

ctgatcgaga caaacggcga aaccggggag atcgtgtggg ataagggccg ggattttgcc     3240

accgtgcgga aagtgctgag catgccccaa gtgaatatcg tgaaaaagac cgaggtgcag     3300

acaggcggct tcagcaaaga gtctatcctg cccaagagga acagcgataa gctgatcgcc     3360

agaaagaagg actgggaccc taagaagtac ggcggcttcg acagccccac cgtggcctat     3420

tctgtgctgg tggtggccaa agtggaaaag ggcaagtcca agaaactgaa gagtgtgaaa     3480

gagctgctgg ggatcaccat catggaaaga agcagcttcg agaagaatcc catcgacttt     3540

ctggaagcca agggctacaa agaagtgaaa aaggacctga tcatcaagct gcctaagtac     3600

tccctgttcg agctggaaaa cggccggaag agaatgctgg cctctgccgg cgaactgcag     3660

aagggaaacg aactggccct gccctccaaa tatgtgaact tcctgtacct ggccagccac     3720

tatgagaagc tgaagggctc ccccgaggat aatgagcaga aacagctgtt tgtggaacag     3780

cacaagcact acctggacga gatcatcgag cagatcagcg agttctccaa gagagtgatc     3840

ctggccgacg ctaatctgga caaagtgctg tccgcctaca acaagcaccg ggataagccc     3900

atcagagagc aggccgagaa tatcatccac ctgtttaccc tgaccaatct gggagcccct     3960

gccgccttca agtactttga caccaccatc gaccggaaga ggtacaccag caccaaagag     4020

gtgctggacg ccaccctgat ccaccagagc atcaccggcc tgtacgagac acggatcgac     4080

ctgtctcagc tgggaggtga c                                               4101


<210>  123
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ala Met Gln Met Gln Leu Glu Ala Asn Ala Asp Thr Ser Val Glu 
1               5                   10                  15      


Glu Glu Ser Phe Gly Pro Gln Pro Ile Ser Arg Leu Glu Gln Cys Gly 
            20                  25                  30          


Ile Asn Ala Asn Asp Val Lys Lys Leu Glu Glu Ala Gly Phe His Thr 
        35                  40                  45              


Val Glu Ala Val Ala Tyr Ala Pro Lys Lys Glu Leu Ile Asn Ile Lys 
    50                  55                  60                  


Gly Ile Ser Glu Ala Lys Ala Asp Lys Ile Leu Ala Glu Ala Ala Lys 
65                  70                  75                  80  


Leu Val Pro Met Gly Phe Thr Thr Ala Thr Glu Phe His Gln Arg Arg 
                85                  90                  95      


Ser Glu Ile Ile Gln Ile Thr Thr Gly Ser Lys Glu Leu Asp Lys Leu 
            100                 105                 110         


Leu Gln Gly Gly Ile Glu Thr Gly Ser Ile Thr Glu Met Phe Gly Glu 
        115                 120                 125             


Phe Arg Thr Gly Lys Thr Gln Ile Cys His Thr Leu Ala Val Thr Cys 
    130                 135                 140                 


Gln Leu Pro Ile Asp Arg Gly Gly Gly Glu Gly Lys Ala Met Tyr Ile 
145                 150                 155                 160 


Asp Thr Glu Gly Thr Phe Arg Pro Glu Arg Leu Leu Ala Val Ala Glu 
                165                 170                 175     


Arg Tyr Gly Leu Ser Gly Ser Asp Val Leu Asp Asn Val Ala Tyr Ala 
            180                 185                 190         


Arg Ala Phe Asn Thr Asp His Gln Thr Gln Leu Leu Tyr Gln Ala Ser 
        195                 200                 205             


Ala Met Met Val Glu Ser Arg Tyr Ala Leu Leu Ile Val Asp Ser Ala 
    210                 215                 220                 


Thr Ala Leu Tyr Arg Thr Asp Tyr Ser Gly Arg Gly Glu Leu Ser Ala 
225                 230                 235                 240 


Arg Gln Met His Leu Ala Arg Phe Leu Arg Met Leu Leu Arg Leu Ala 
                245                 250                 255     


Asp Glu Phe Gly Val Ala Val Val Ile Thr Asn Gln Val Val Ala Gln 
            260                 265                 270         


Val Asp Gly Ala Ala Met Phe Ala Ala Asp Pro Lys Lys Pro Ile Gly 
        275                 280                 285             


Gly Asn Ile Ile Ala His Ala Ser Thr Thr Arg Leu Tyr Leu Arg Lys 
    290                 295                 300                 


Gly Arg Gly Glu Thr Arg Ile Cys Lys Ile Tyr Asp Ser Pro Cys Leu 
305                 310                 315                 320 


Pro Glu Ala Glu Ala Met Phe Ala Ile Asn Ala Asp Gly Val Gly Asp 
                325                 330                 335     


Ala Lys Asp 
            


<210>  124
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Ser Gly Thr Glu Glu Ala Ile Leu Gly Gly Arg Asp Ser His Pro 
1               5                   10                  15      


Ala Ala Gly Gly Gly Ser Val Leu Cys Phe Gly Gln Cys Gln Tyr Thr 
            20                  25                  30          


Ala Glu Glu Tyr Gln Ala Ile Gln Lys Ala Leu Arg Gln Arg Leu Gly 
        35                  40                  45              


Pro Glu Tyr Ile Ser Ser Arg Met Ala Gly Gly Gly Gln Lys Val Cys 
    50                  55                  60                  


Tyr Ile Glu Gly His Arg Val Ile Asn Leu Ala Asn Glu Met Phe Gly 
65                  70                  75                  80  


Tyr Asn Gly Trp Ala His Ser Ile Thr Gln Gln Asn Val Asp Phe Val 
                85                  90                  95      


Asp Leu Asn Asn Gly Lys Phe Tyr Val Gly Val Cys Ala Phe Val Arg 
            100                 105                 110         


Val Gln Leu Lys Asp Gly Ser Tyr His Glu Asp Val Gly Tyr Gly Val 
        115                 120                 125             


Ser Glu Gly Leu Lys Ser Lys Ala Leu Ser Leu Glu Lys Ala Arg Lys 
    130                 135                 140                 


Glu Ala Val Thr Asp Gly Leu Lys Arg Ala Leu Arg Ser Phe Gly Asn 
145                 150                 155                 160 


Ala Leu Gly Asn Cys Ile Leu Asp Lys Asp Tyr Leu Arg Ser Leu Asn 
                165                 170                 175     


Lys Leu Pro Arg Gln Leu Pro Leu Glu Val Asp Leu Thr Lys Ala Lys 
            180                 185                 190         


Arg Gln Asp Leu Glu Pro Ser Val Glu Glu Ala Arg Tyr Asn Ser Cys 
        195                 200                 205             


Arg Pro Asn Met Ala Leu Gly His Pro Gln Leu Gln Gln Val Thr Ser 
    210                 215                 220                 


Pro Ser Arg Pro Ser His Ala Val Ile Pro Ala Asp Gln Asp Cys Ser 
225                 230                 235                 240 


Ser Arg Ser Leu Ser Ser Ser Ala Val Glu Ser Glu Ala Thr His Gln 
                245                 250                 255     


Arg Lys Leu Arg Gln Lys Gln Leu Gln Gln Gln Phe Arg Glu Arg Met 
            260                 265                 270         


Glu Lys Gln Gln Val Arg Val Ser Thr Pro Ser Ala Glu Lys Ser Glu 
        275                 280                 285             


Ala Ala Pro Pro Ala Pro Pro Val Thr His Ser Thr Pro Val Thr Val 
    290                 295                 300                 


Ser Glu Pro Leu Leu Glu Lys Asp Phe Leu Ala Gly Val Thr Gln Glu 
305                 310                 315                 320 


Leu Ile Lys Thr Leu Glu Asp Asn Ser Glu Lys Trp Ala Val Thr Pro 
                325                 330                 335     


Asp Ala Gly Asp Gly Val Val Lys Pro Ser Ser Arg Ala Asp Pro Ala 
            340                 345                 350         


Gln Thr Ser Asp Thr Leu Ala Leu Asn Asn Gln Met Val Thr Gln Asn 
        355                 360                 365             


Arg Thr Pro His Ser Val Cys His Gln Lys Pro Gln Ala Lys Ser Gly 
    370                 375                 380                 


Ser Trp Asp Leu Gln Thr Tyr Ser Ala Asp Gln Arg Thr Thr Gly Asn 
385                 390                 395                 400 


Trp Glu Ser His Arg Lys Ser Gln Asp Met Lys Lys Arg Lys Tyr Asp 
                405                 410                 415     


Pro Ser 
        


<210>  125
<211>  348
<212>  PRT
<213>  Bacillus subtilis

<400>  125

Met Ser Asp Arg Gln Ala Ala Leu Asp Met Ala Leu Lys Gln Ile Glu 
1               5                   10                  15      


Lys Gln Phe Gly Lys Gly Ser Ile Met Lys Leu Gly Glu Lys Thr Asp 
            20                  25                  30          


Thr Arg Ile Ser Thr Val Pro Ser Gly Ser Leu Ala Leu Asp Thr Ala 
        35                  40                  45              


Leu Gly Ile Gly Gly Tyr Pro Arg Gly Arg Ile Ile Glu Val Tyr Gly 
    50                  55                  60                  


Pro Glu Ser Ser Gly Lys Thr Thr Val Ala Leu His Ala Ile Ala Glu 
65                  70                  75                  80  


Val Gln Gln Gln Gly Gly Gln Ala Ala Phe Ile Asp Ala Glu His Ala 
                85                  90                  95      


Leu Asp Pro Val Tyr Ala Gln Lys Leu Gly Val Asn Ile Glu Glu Leu 
            100                 105                 110         


Leu Leu Ser Gln Pro Asp Thr Gly Glu Gln Ala Leu Glu Ile Ala Glu 
        115                 120                 125             


Ala Leu Val Arg Ser Gly Ala Val Asp Ile Val Val Val Asp Ser Val 
    130                 135                 140                 


Ala Ala Leu Val Pro Lys Ala Glu Ile Glu Gly Asp Met Gly Asp Ser 
145                 150                 155                 160 


His Val Gly Leu Gln Ala Arg Leu Met Ser Gln Ala Leu Arg Lys Leu 
                165                 170                 175     


Ser Gly Ala Ile Asn Lys Ser Lys Thr Ile Ala Ile Phe Ile Asn Gln 
            180                 185                 190         


Ile Arg Glu Lys Val Gly Val Met Phe Gly Asn Pro Glu Thr Thr Pro 
        195                 200                 205             


Gly Gly Arg Ala Leu Lys Phe Tyr Ser Ser Val Arg Leu Glu Val Arg 
    210                 215                 220                 


Arg Ala Glu Gln Leu Lys Gln Gly Asn Asp Val Met Gly Asn Lys Thr 
225                 230                 235                 240 


Lys Ile Lys Val Val Lys Asn Lys Val Ala Pro Pro Phe Arg Thr Ala 
                245                 250                 255     


Glu Val Asp Ile Met Tyr Gly Glu Gly Ile Ser Lys Glu Gly Glu Ile 
            260                 265                 270         


Ile Asp Leu Gly Thr Glu Leu Asp Ile Val Gln Lys Ser Gly Ser Trp 
        275                 280                 285             


Tyr Ser Tyr Glu Glu Glu Arg Leu Gly Gln Gly Arg Glu Asn Ala Lys 
    290                 295                 300                 


Gln Phe Leu Lys Glu Asn Lys Asp Ile Met Leu Met Ile Gln Glu Gln 
305                 310                 315                 320 


Ile Arg Glu His Tyr Gly Leu Asp Asn Asn Gly Val Val Gln Gln Gln 
                325                 330                 335     


Ala Glu Glu Thr Gln Glu Glu Leu Glu Phe Glu Glu 
            340                 345             


<210>  126
<211>  353
<212>  PRT
<213>  Escherichia coli

<400>  126

Met Ala Ile Asp Glu Asn Lys Gln Lys Ala Leu Ala Ala Ala Leu Gly 
1               5                   10                  15      


Gln Ile Glu Lys Gln Phe Gly Lys Gly Ser Ile Met Arg Leu Gly Glu 
            20                  25                  30          


Asp Arg Ser Met Asp Val Glu Thr Ile Ser Thr Gly Ser Leu Ser Leu 
        35                  40                  45              


Asp Ile Ala Leu Gly Ala Gly Gly Leu Pro Met Gly Arg Ile Val Glu 
    50                  55                  60                  


Ile Tyr Gly Pro Glu Ser Ser Gly Lys Thr Thr Leu Thr Leu Gln Val 
65                  70                  75                  80  


Ile Ala Ala Ala Gln Arg Glu Gly Lys Thr Cys Ala Phe Ile Asp Ala 
                85                  90                  95      


Glu His Ala Leu Asp Pro Ile Tyr Ala Arg Lys Leu Gly Val Asp Ile 
            100                 105                 110         


Asp Asn Leu Leu Cys Ser Gln Pro Asp Thr Gly Glu Gln Ala Leu Glu 
        115                 120                 125             


Ile Cys Asp Ala Leu Ala Arg Ser Gly Ala Val Asp Val Ile Val Val 
    130                 135                 140                 


Asp Ser Val Ala Ala Leu Thr Pro Lys Ala Glu Ile Glu Gly Glu Ile 
145                 150                 155                 160 


Gly Asp Ser His Met Gly Leu Ala Ala Arg Met Met Ser Gln Ala Met 
                165                 170                 175     


Arg Lys Leu Ala Gly Asn Leu Lys Gln Ser Asn Thr Leu Leu Ile Phe 
            180                 185                 190         


Ile Asn Gln Ile Arg Met Lys Ile Gly Val Met Phe Gly Asn Pro Glu 
        195                 200                 205             


Thr Thr Thr Gly Gly Asn Ala Leu Lys Phe Tyr Ala Ser Val Arg Leu 
    210                 215                 220                 


Asp Ile Arg Arg Ile Gly Ala Val Lys Glu Gly Glu Asn Val Val Gly 
225                 230                 235                 240 


Ser Glu Thr Arg Val Lys Val Val Lys Asn Lys Ile Ala Ala Pro Phe 
                245                 250                 255     


Lys Gln Ala Glu Phe Gln Ile Leu Tyr Gly Glu Gly Ile Asn Phe Tyr 
            260                 265                 270         


Gly Glu Leu Val Asp Leu Gly Val Lys Glu Lys Leu Ile Glu Lys Ala 
        275                 280                 285             


Gly Ala Trp Tyr Ser Tyr Lys Gly Glu Lys Ile Gly Gln Gly Lys Ala 
    290                 295                 300                 


Asn Ala Thr Ala Trp Leu Lys Asp Asn Pro Glu Thr Ala Lys Glu Ile 
305                 310                 315                 320 


Glu Lys Lys Val Arg Glu Leu Leu Leu Ser Asn Pro Asn Ser Thr Pro 
                325                 330                 335     


Asp Phe Ser Val Asp Asp Ser Glu Gly Val Ala Glu Thr Asn Glu Asp 
            340                 345                 350         


Phe 
    


<210>  127
<211>  162
<212>  PRT
<213>  Escherichia phage P1

<400>  127

Met Ala Gln Arg Gly Val Asn Lys Val Ile Leu Ile Gly Thr Leu Gly 
1               5                   10                  15      


Gln Asp Pro Glu Ile Arg Tyr Ile Pro Asn Gly Gly Ala Val Gly Arg 
            20                  25                  30          


Leu Ser Ile Ala Thr Asn Glu Ser Trp Arg Asp Lys Gln Thr Gly Gln 
        35                  40                  45              


Gln Lys Glu Gln Thr Glu Trp His Lys Val Val Leu Phe Gly Lys Leu 
    50                  55                  60                  


Ala Glu Ile Ala Ser Glu Tyr Leu Arg Lys Gly Ser Gln Val Tyr Ile 
65                  70                  75                  80  


Glu Gly Lys Leu Lys Thr Arg Lys Trp Thr Asp Asp Ala Gly Val Glu 
                85                  90                  95      


Arg Tyr Thr Thr Glu Ile Ile Val Ser Gln Gly Gly Thr Met Gln Met 
            100                 105                 110         


Ile Gly Ala Arg Arg Asp Asp Ser Gln Ser Ser Asn Gly Trp Gly Gln 
        115                 120                 125             


Ser Asn Gln Pro Gln Asn His Gln Gln Tyr Ser Gly Gly Gly Lys Pro 
    130                 135                 140                 


Gln Ser Asn Ala Asn Asn Glu Pro Pro Met Asp Phe Asp Asp Asp Ile 
145                 150                 155                 160 


Pro Phe 
        


<210>  128
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  128

Ala Leu Asp Phe Leu Ser Arg Leu Pro Leu Pro Pro Pro Val Ser Pro 
1               5                   10                  15      


Ile Cys Thr Phe Val Ser Pro Ala Ala Gln Lys Ala Phe Gln Pro Pro 
            20                  25                  30          


Arg Ser Cys Gly 
        35      


<210>  129
<211>  866
<212>  PRT
<213>  Escherichia coli

<400>  129

Met Ser Thr Lys Pro Leu Phe Leu Leu Arg Lys Ala Lys Lys Ser Ser 
1               5                   10                  15      


Gly Glu Pro Asp Val Val Leu Trp Ala Ser Asn Asp Phe Glu Ser Thr 
            20                  25                  30          


Cys Ala Thr Leu Asp Tyr Leu Ile Val Lys Ser Gly Lys Lys Leu Ser 
        35                  40                  45              


Ser Tyr Phe Lys Ala Val Ala Thr Asn Phe Pro Val Val Asn Asp Leu 
    50                  55                  60                  


Pro Ala Glu Gly Glu Ile Asp Phe Thr Trp Ser Glu Arg Tyr Gln Leu 
65                  70                  75                  80  


Ser Lys Asp Ser Met Thr Trp Glu Leu Lys Pro Gly Ala Ala Pro Asp 
                85                  90                  95      


Asn Ala His Tyr Gln Gly Asn Thr Asn Val Asn Gly Glu Asp Met Thr 
            100                 105                 110         


Glu Ile Glu Glu Asn Met Leu Leu Pro Ile Ser Gly Gln Glu Leu Pro 
        115                 120                 125             


Ile Arg Trp Leu Ala Gln His Gly Ser Glu Lys Pro Val Thr His Val 
    130                 135                 140                 


Ser Arg Asp Gly Leu Gln Ala Leu His Ile Ala Arg Ala Glu Glu Leu 
145                 150                 155                 160 


Pro Ala Val Thr Ala Leu Ala Val Ser His Lys Thr Ser Leu Leu Asp 
                165                 170                 175     


Pro Leu Glu Ile Arg Glu Leu His Lys Leu Val Arg Asp Thr Asp Lys 
            180                 185                 190         


Val Phe Pro Asn Pro Gly Asn Ser Asn Leu Gly Leu Ile Thr Ala Phe 
        195                 200                 205             


Phe Glu Ala Tyr Leu Asn Ala Asp Tyr Thr Asp Arg Gly Leu Leu Thr 
    210                 215                 220                 


Lys Glu Trp Met Lys Gly Asn Arg Val Ser His Ile Thr Arg Thr Ala 
225                 230                 235                 240 


Ser Gly Ala Asn Ala Gly Gly Gly Asn Leu Thr Asp Arg Gly Glu Gly 
                245                 250                 255     


Phe Val His Asp Leu Thr Ser Leu Ala Arg Asp Val Ala Thr Gly Val 
            260                 265                 270         


Leu Ala Arg Ser Met Asp Leu Asp Ile Tyr Asn Leu His Pro Ala His 
        275                 280                 285             


Ala Lys Arg Ile Glu Glu Ile Ile Ala Glu Asn Lys Pro Pro Phe Ser 
    290                 295                 300                 


Val Phe Arg Asp Lys Phe Ile Thr Met Pro Gly Gly Leu Asp Tyr Ser 
305                 310                 315                 320 


Arg Ala Ile Val Val Ala Ser Val Lys Glu Ala Pro Ile Gly Ile Glu 
                325                 330                 335     


Val Ile Pro Ala His Val Thr Glu Tyr Leu Asn Lys Val Leu Thr Glu 
            340                 345                 350         


Thr Asp His Ala Asn Pro Asp Pro Glu Ile Val Asp Ile Ala Cys Gly 
        355                 360                 365             


Arg Ser Ser Ala Pro Met Pro Gln Arg Val Thr Glu Glu Gly Lys Gln 
    370                 375                 380                 


Asp Asp Glu Glu Lys Pro Gln Pro Ser Gly Thr Thr Ala Val Glu Gln 
385                 390                 395                 400 


Gly Glu Ala Glu Thr Met Glu Pro Asp Ala Thr Glu His His Gln Asp 
                405                 410                 415     


Thr Gln Pro Leu Asp Ala Gln Ser Gln Val Asn Ser Val Asp Ala Lys 
            420                 425                 430         


Tyr Gln Glu Leu Arg Ala Glu Leu His Glu Ala Arg Lys Asn Ile Pro 
        435                 440                 445             


Ser Lys Asn Pro Val Asp Asp Asp Lys Leu Leu Ala Ala Ser Arg Gly 
    450                 455                 460                 


Glu Phe Val Asp Gly Ile Ser Asp Pro Asn Asp Pro Lys Trp Val Lys 
465                 470                 475                 480 


Gly Ile Gln Thr Arg Asp Cys Val Tyr Gln Asn Gln Pro Glu Thr Glu 
                485                 490                 495     


Lys Thr Ser Pro Asp Met Asn Gln Pro Glu Pro Val Val Gln Gln Glu 
            500                 505                 510         


Pro Glu Ile Ala Cys Asn Ala Cys Gly Gln Thr Gly Gly Asp Asn Cys 
        515                 520                 525             


Pro Asp Cys Gly Ala Val Met Gly Asp Ala Thr Tyr Gln Glu Thr Phe 
    530                 535                 540                 


Asp Glu Glu Ser Gln Val Glu Ala Lys Glu Asn Asp Pro Glu Glu Met 
545                 550                 555                 560 


Glu Gly Ala Glu His Pro His Asn Glu Asn Ala Gly Ser Asp Pro His 
                565                 570                 575     


Arg Asp Cys Ser Asp Glu Thr Gly Glu Val Ala Asp Pro Val Ile Val 
            580                 585                 590         


Glu Asp Ile Glu Pro Gly Ile Tyr Tyr Gly Ile Ser Asn Glu Asn Tyr 
        595                 600                 605             


His Ala Gly Pro Gly Ile Ser Lys Ser Gln Leu Asp Asp Ile Ala Asp 
    610                 615                 620                 


Thr Pro Ala Leu Tyr Leu Trp Arg Lys Asn Ala Pro Val Asp Thr Thr 
625                 630                 635                 640 


Lys Thr Lys Thr Leu Asp Leu Gly Thr Ala Phe His Cys Arg Val Leu 
                645                 650                 655     


Glu Pro Glu Glu Phe Ser Asn Arg Phe Ile Val Ala Pro Glu Phe Asn 
            660                 665                 670         


Arg Arg Thr Asn Ala Gly Lys Glu Glu Glu Lys Ala Phe Leu Met Glu 
        675                 680                 685             


Cys Ala Ser Thr Gly Lys Thr Val Ile Thr Ala Glu Glu Gly Arg Lys 
    690                 695                 700                 


Ile Glu Leu Met Tyr Gln Ser Val Met Ala Leu Pro Leu Gly Gln Trp 
705                 710                 715                 720 


Leu Val Glu Ser Ala Gly His Ala Glu Ser Ser Ile Tyr Trp Glu Asp 
                725                 730                 735     


Pro Glu Thr Gly Ile Leu Cys Arg Cys Arg Pro Asp Lys Ile Ile Pro 
            740                 745                 750         


Glu Phe His Trp Ile Met Asp Val Lys Thr Thr Ala Asp Ile Gln Arg 
        755                 760                 765             


Phe Lys Thr Ala Tyr Tyr Asp Tyr Arg Tyr His Val Gln Asp Ala Phe 
    770                 775                 780                 


Tyr Ser Asp Gly Tyr Glu Ala Gln Phe Gly Val Gln Pro Thr Phe Val 
785                 790                 795                 800 


Phe Leu Val Ala Ser Thr Thr Ile Glu Cys Gly Arg Tyr Pro Val Glu 
                805                 810                 815     


Ile Phe Met Met Gly Glu Glu Ala Lys Leu Ala Gly Gln Gln Glu Tyr 
            820                 825                 830         


His Arg Asn Leu Arg Thr Leu Ser Asp Cys Leu Asn Thr Asp Glu Trp 
        835                 840                 845             


Pro Ala Ile Lys Thr Leu Ser Leu Pro Arg Trp Ala Lys Glu Tyr Ala 
    850                 855                 860                 


Asn Asp 
865     


<210>  130
<211>  577
<212>  PRT
<213>  Escherichia coli

<400>  130

Met Lys Gln Gln Ile Gln Leu Arg Arg Arg Glu Val Asp Glu Thr Ala 
1               5                   10                  15      


Asp Leu Pro Ala Glu Leu Pro Pro Leu Leu Arg Arg Leu Tyr Ala Ser 
            20                  25                  30          


Arg Gly Val Arg Ser Ala Gln Glu Leu Glu Arg Ser Val Lys Gly Met 
        35                  40                  45              


Leu Pro Trp Gln Gln Leu Ser Gly Val Glu Lys Ala Val Glu Ile Leu 
    50                  55                  60                  


Tyr Asn Ala Phe Arg Glu Gly Thr Arg Ile Ile Val Val Gly Asp Phe 
65                  70                  75                  80  


Asp Ala Asp Gly Ala Thr Ser Thr Ala Leu Ser Val Leu Ala Met Arg 
                85                  90                  95      


Ser Leu Gly Cys Ser Asn Ile Asp Tyr Leu Val Pro Asn Arg Phe Glu 
            100                 105                 110         


Asp Gly Tyr Gly Leu Ser Pro Glu Val Val Asp Gln Ala His Ala Arg 
        115                 120                 125             


Gly Ala Gln Leu Ile Val Thr Val Asp Asn Gly Ile Ser Ser His Ala 
    130                 135                 140                 


Gly Val Glu His Ala Arg Ser Leu Gly Ile Pro Val Ile Val Thr Asp 
145                 150                 155                 160 


His His Leu Pro Gly Asp Thr Leu Pro Ala Ala Glu Ala Ile Ile Asn 
                165                 170                 175     


Pro Asn Leu Arg Asp Cys Asn Phe Pro Ser Lys Ser Leu Ala Gly Val 
            180                 185                 190         


Gly Val Ala Phe Tyr Leu Met Leu Ala Leu Arg Thr Phe Leu Arg Asp 
        195                 200                 205             


Gln Gly Trp Phe Asp Glu Arg Asn Ile Ala Ile Pro Asn Leu Ala Glu 
    210                 215                 220                 


Leu Leu Asp Leu Val Ala Leu Gly Thr Val Ala Asp Val Val Pro Leu 
225                 230                 235                 240 


Asp Ala Asn Asn Arg Ile Leu Thr Trp Gln Gly Met Ser Arg Ile Arg 
                245                 250                 255     


Ala Gly Lys Cys Arg Pro Gly Ile Lys Ala Leu Leu Glu Val Ala Asn 
            260                 265                 270         


Arg Asp Ala Gln Lys Leu Ala Ala Ser Asp Leu Gly Phe Ala Leu Gly 
        275                 280                 285             


Pro Arg Leu Asn Ala Ala Gly Arg Leu Asp Asp Met Ser Val Gly Val 
    290                 295                 300                 


Ala Leu Leu Leu Cys Asp Asn Ile Gly Glu Ala Arg Val Leu Ala Asn 
305                 310                 315                 320 


Glu Leu Asp Ala Leu Asn Gln Thr Arg Lys Glu Ile Glu Gln Gly Met 
                325                 330                 335     


Gln Ile Glu Ala Leu Thr Leu Cys Glu Lys Leu Glu Arg Ser Arg Asp 
            340                 345                 350         


Thr Leu Pro Gly Gly Leu Ala Met Tyr His Pro Glu Trp His Gln Gly 
        355                 360                 365             


Val Val Gly Ile Leu Ala Ser Arg Ile Lys Glu Arg Phe His Arg Pro 
    370                 375                 380                 


Val Ile Ala Phe Ala Pro Ala Gly Asp Gly Thr Leu Lys Gly Ser Gly 
385                 390                 395                 400 


Arg Ser Ile Gln Gly Leu His Met Arg Asp Ala Leu Glu Arg Leu Asp 
                405                 410                 415     


Thr Leu Tyr Pro Gly Met Met Leu Lys Phe Gly Gly His Ala Met Ala 
            420                 425                 430         


Ala Gly Leu Ser Leu Glu Glu Asp Lys Phe Lys Leu Phe Gln Gln Arg 
        435                 440                 445             


Phe Gly Glu Leu Val Thr Glu Trp Leu Asp Pro Ser Leu Leu Gln Gly 
    450                 455                 460                 


Glu Val Val Ser Asp Gly Pro Leu Ser Pro Ala Glu Met Thr Met Glu 
465                 470                 475                 480 


Val Ala Gln Leu Leu Arg Asp Ala Gly Pro Trp Gly Gln Met Phe Pro 
                485                 490                 495     


Glu Pro Leu Phe Asp Gly His Phe Arg Leu Leu Gln Gln Arg Leu Val 
            500                 505                 510         


Gly Glu Arg His Leu Lys Val Met Val Glu Pro Val Gly Gly Gly Pro 
        515                 520                 525             


Leu Leu Asp Gly Ile Ala Phe Asn Val Asp Thr Ala Leu Trp Pro Asp 
    530                 535                 540                 


Asn Gly Val Arg Glu Val Gln Leu Ala Tyr Lys Leu Asp Ile Asn Glu 
545                 550                 555                 560 


Phe Arg Gly Asn Arg Ser Leu Gln Ile Ile Ile Asp Asn Ile Trp Pro 
                565                 570                 575     


Ile 
    


<210>  131
<211>  291
<212>  PRT
<213>  Escherichia phage T5

<400>  131

Met Ser Lys Ser Trp Gly Lys Phe Ile Glu Glu Glu Glu Ala Glu Met 
1               5                   10                  15      


Ala Ser Arg Arg Asn Leu Met Ile Val Asp Gly Thr Asn Leu Gly Phe 
            20                  25                  30          


Arg Phe Lys His Asn Asn Ser Lys Lys Pro Phe Ala Ser Ser Tyr Val 
        35                  40                  45              


Ser Thr Ile Gln Ser Leu Ala Lys Ser Tyr Ser Ala Arg Thr Thr Ile 
    50                  55                  60                  


Val Leu Gly Asp Lys Gly Lys Ser Val Phe Arg Leu Glu His Leu Pro 
65                  70                  75                  80  


Glu Tyr Lys Gly Asn Arg Asp Glu Lys Tyr Ala Gln Arg Thr Glu Glu 
                85                  90                  95      


Glu Lys Ala Leu Asp Glu Gln Phe Phe Glu Tyr Leu Lys Asp Ala Phe 
            100                 105                 110         


Glu Leu Cys Lys Thr Thr Phe Pro Thr Phe Thr Ile Arg Gly Val Glu 
        115                 120                 125             


Ala Asp Asp Met Ala Ala Tyr Ile Val Lys Leu Ile Gly His Leu Tyr 
    130                 135                 140                 


Asp His Val Trp Leu Ile Ser Thr Asp Gly Asp Trp Asp Thr Leu Leu 
145                 150                 155                 160 


Thr Asp Lys Val Ser Arg Phe Ser Phe Thr Thr Arg Arg Glu Tyr His 
                165                 170                 175     


Leu Arg Asp Met Tyr Glu His His Asn Val Asp Asp Val Glu Gln Phe 
            180                 185                 190         


Ile Ser Leu Lys Ala Ile Met Gly Asp Leu Gly Asp Asn Ile Arg Gly 
        195                 200                 205             


Val Glu Gly Ile Gly Ala Lys Arg Gly Tyr Asn Ile Ile Arg Glu Phe 
    210                 215                 220                 


Gly Asn Val Leu Asp Ile Ile Asp Gln Leu Pro Leu Pro Gly Lys Gln 
225                 230                 235                 240 


Lys Tyr Ile Gln Asn Leu Asn Ala Ser Glu Glu Leu Leu Phe Arg Asn 
                245                 250                 255     


Leu Ile Leu Val Asp Leu Pro Thr Tyr Cys Val Asp Ala Ile Ala Ala 
            260                 265                 270         


Val Gly Gln Asp Val Leu Asp Lys Phe Thr Lys Asp Ile Leu Glu Ile 
        275                 280                 285             


Ala Glu Gln 
    290     


<210>  132
<211>  300
<212>  PRT
<213>  Escherichia phage T7

<400>  132

Met Ala Leu Leu Asp Leu Lys Gln Phe Tyr Glu Leu Arg Glu Gly Cys 
1               5                   10                  15      


Asp Asp Lys Gly Ile Leu Val Met Asp Gly Asp Trp Leu Val Phe Gln 
            20                  25                  30          


Ala Met Ser Ala Ala Glu Phe Asp Ala Ser Trp Glu Glu Glu Ile Trp 
        35                  40                  45              


His Arg Cys Cys Asp His Ala Lys Ala Arg Gln Ile Leu Glu Asp Ser 
    50                  55                  60                  


Ile Lys Ser Tyr Glu Thr Arg Lys Lys Ala Trp Ala Gly Ala Pro Ile 
65                  70                  75                  80  


Val Leu Ala Phe Thr Asp Ser Val Asn Trp Arg Lys Glu Leu Val Asp 
                85                  90                  95      


Pro Asn Tyr Lys Ala Asn Arg Lys Ala Val Lys Lys Pro Val Gly Tyr 
            100                 105                 110         


Phe Glu Phe Leu Asp Ala Leu Phe Glu Arg Glu Glu Phe Tyr Cys Ile 
        115                 120                 125             


Arg Glu Pro Met Leu Glu Gly Asp Asp Val Met Gly Val Ile Ala Ser 
    130                 135                 140                 


Asn Pro Ser Ala Phe Gly Ala Arg Lys Ala Val Ile Ile Ser Cys Asp 
145                 150                 155                 160 


Lys Asp Phe Lys Thr Ile Pro Asn Cys Asp Phe Leu Trp Cys Thr Thr 
                165                 170                 175     


Gly Asn Ile Leu Thr Gln Thr Glu Glu Ser Ala Asp Trp Trp His Leu 
            180                 185                 190         


Phe Gln Thr Ile Lys Gly Asp Ile Thr Asp Gly Tyr Ser Gly Ile Ala 
        195                 200                 205             


Gly Trp Gly Asp Thr Ala Glu Asp Phe Leu Asn Asn Pro Phe Ile Thr 
    210                 215                 220                 


Glu Pro Lys Thr Ser Val Leu Lys Ser Gly Lys Asn Lys Gly Gln Glu 
225                 230                 235                 240 


Val Thr Lys Trp Val Lys Arg Asp Pro Glu Pro His Glu Thr Leu Trp 
                245                 250                 255     


Asp Cys Ile Lys Ser Ile Gly Ala Lys Ala Gly Met Thr Glu Glu Asp 
            260                 265                 270         


Ile Ile Lys Gln Gly Gln Met Ala Arg Ile Leu Arg Phe Asn Glu Tyr 
        275                 280                 285             


Asn Phe Ile Asp Lys Glu Ile Tyr Leu Trp Arg Pro 
    290                 295                 300 


<210>  133
<211>  226
<212>  PRT
<213>  Escherichia phage lambda

<400>  133

Met Thr Pro Asp Ile Ile Leu Gln Arg Thr Gly Ile Asp Val Arg Ala 
1               5                   10                  15      


Val Glu Gln Gly Asp Asp Ala Trp His Lys Leu Arg Leu Gly Val Ile 
            20                  25                  30          


Thr Ala Ser Glu Val His Asn Val Ile Ala Lys Pro Arg Ser Gly Lys 
        35                  40                  45              


Lys Trp Pro Asp Met Lys Met Ser Tyr Phe His Thr Leu Leu Ala Glu 
    50                  55                  60                  


Val Cys Thr Gly Val Ala Pro Glu Val Asn Ala Lys Ala Leu Ala Trp 
65                  70                  75                  80  


Gly Lys Gln Tyr Glu Asn Asp Ala Arg Thr Leu Phe Glu Phe Thr Ser 
                85                  90                  95      


Gly Val Asn Val Thr Glu Ser Pro Ile Ile Tyr Arg Asp Glu Ser Met 
            100                 105                 110         


Arg Thr Ala Cys Ser Pro Asp Gly Leu Cys Ser Asp Gly Asn Gly Leu 
        115                 120                 125             


Glu Leu Lys Cys Pro Phe Thr Ser Arg Asp Phe Met Lys Phe Arg Leu 
    130                 135                 140                 


Gly Gly Phe Glu Ala Ile Lys Ser Ala Tyr Met Ala Gln Val Gln Tyr 
145                 150                 155                 160 


Ser Met Trp Val Thr Arg Lys Asn Ala Trp Tyr Phe Ala Asn Tyr Asp 
                165                 170                 175     


Pro Arg Met Lys Arg Glu Gly Leu His Tyr Val Val Ile Glu Arg Asp 
            180                 185                 190         


Glu Lys Tyr Met Ala Ser Phe Asp Glu Ile Val Pro Glu Phe Ile Glu 
        195                 200                 205             


Lys Met Asp Glu Ala Leu Ala Glu Ile Gly Phe Val Phe Gly Glu Gln 
    210                 215                 220                 


Trp Arg 
225     


<210>  134
<211>  475
<212>  PRT
<213>  Escherichia coli

<400>  134

Met Met Asn Asp Gly Lys Gln Gln Ser Thr Phe Leu Phe His Asp Tyr 
1               5                   10                  15      


Glu Thr Phe Gly Thr His Pro Ala Leu Asp Arg Pro Ala Gln Phe Ala 
            20                  25                  30          


Ala Ile Arg Thr Asp Ser Glu Phe Asn Val Ile Gly Glu Pro Glu Val 
        35                  40                  45              


Phe Tyr Cys Lys Pro Ala Asp Asp Tyr Leu Pro Gln Pro Gly Ala Val 
    50                  55                  60                  


Leu Ile Thr Gly Ile Thr Pro Gln Glu Ala Arg Ala Lys Gly Glu Asn 
65                  70                  75                  80  


Glu Ala Ala Phe Ala Ala Arg Ile His Ser Leu Phe Thr Val Pro Lys 
                85                  90                  95      


Thr Cys Ile Leu Gly Tyr Asn Asn Val Arg Phe Asp Asp Glu Val Thr 
            100                 105                 110         


Arg Asn Ile Phe Tyr Arg Asn Phe Tyr Asp Pro Tyr Ala Trp Ser Trp 
        115                 120                 125             


Gln His Asp Asn Ser Arg Trp Asp Leu Leu Asp Val Met Arg Ala Cys 
    130                 135                 140                 


Tyr Ala Leu Arg Pro Glu Gly Ile Asn Trp Pro Glu Asn Asp Asp Gly 
145                 150                 155                 160 


Leu Pro Ser Phe Arg Leu Glu His Leu Thr Lys Ala Asn Gly Ile Glu 
                165                 170                 175     


His Ser Asn Ala His Asp Ala Met Ala Asp Val Tyr Ala Thr Ile Ala 
            180                 185                 190         


Met Ala Lys Leu Val Lys Thr Arg Gln Pro Arg Leu Phe Asp Tyr Leu 
        195                 200                 205             


Phe Thr His Arg Asn Lys His Lys Leu Met Ala Leu Ile Asp Val Pro 
    210                 215                 220                 


Gln Met Lys Pro Leu Val His Val Ser Gly Met Phe Gly Ala Trp Arg 
225                 230                 235                 240 


Gly Asn Thr Ser Trp Val Ala Pro Leu Ala Trp His Pro Glu Asn Arg 
                245                 250                 255     


Asn Ala Val Ile Met Val Asp Leu Ala Gly Asp Ile Ser Pro Leu Leu 
            260                 265                 270         


Glu Leu Asp Ser Asp Thr Leu Arg Glu Arg Leu Tyr Thr Ala Lys Thr 
        275                 280                 285             


Asp Leu Gly Asp Asn Ala Ala Val Pro Val Lys Leu Val His Ile Asn 
    290                 295                 300                 


Lys Cys Pro Val Leu Ala Gln Ala Asn Thr Leu Arg Pro Glu Asp Ala 
305                 310                 315                 320 


Asp Arg Leu Gly Ile Asn Arg Gln His Cys Leu Asp Asn Leu Lys Ile 
                325                 330                 335     


Leu Arg Glu Asn Pro Gln Val Arg Glu Lys Val Val Ala Ile Phe Ala 
            340                 345                 350         


Glu Ala Glu Pro Phe Thr Pro Ser Asp Asn Val Asp Ala Gln Leu Tyr 
        355                 360                 365             


Asn Gly Phe Phe Ser Asp Ala Asp Arg Ala Ala Met Lys Ile Val Leu 
    370                 375                 380                 


Glu Thr Glu Pro Arg Asn Leu Pro Ala Leu Asp Ile Thr Phe Val Asp 
385                 390                 395                 400 


Lys Arg Ile Glu Lys Leu Leu Phe Asn Tyr Arg Ala Arg Asn Phe Pro 
                405                 410                 415     


Gly Thr Leu Asp Tyr Ala Glu Gln Gln Arg Trp Leu Glu His Arg Arg 
            420                 425                 430         


Gln Val Phe Thr Pro Glu Phe Leu Gln Gly Tyr Ala Asp Glu Leu Gln 
        435                 440                 445             


Met Leu Val Gln Gln Tyr Ala Asp Asp Lys Glu Lys Val Ala Leu Leu 
    450                 455                 460                 


Lys Ala Leu Trp Gln Tyr Ala Glu Glu Ile Val 
465                 470                 475 


<210>  135
<211>  846
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Gly Ile Gln Gly Leu Leu Gln Phe Ile Lys Glu Ala Ser Glu Pro 
1               5                   10                  15      


Ile His Val Arg Lys Tyr Lys Gly Gln Val Val Ala Val Asp Thr Tyr 
            20                  25                  30          


Cys Trp Leu His Lys Gly Ala Ile Ala Cys Ala Glu Lys Leu Ala Lys 
        35                  40                  45              


Gly Glu Pro Thr Asp Arg Tyr Val Gly Phe Cys Met Lys Phe Val Asn 
    50                  55                  60                  


Met Leu Leu Ser His Gly Ile Lys Pro Ile Leu Val Phe Asp Gly Cys 
65                  70                  75                  80  


Thr Leu Pro Ser Lys Lys Glu Val Glu Arg Ser Arg Arg Glu Arg Arg 
                85                  90                  95      


Gln Ala Asn Leu Leu Lys Gly Lys Gln Leu Leu Arg Glu Gly Lys Val 
            100                 105                 110         


Ser Glu Ala Arg Glu Cys Phe Thr Arg Ser Ile Asn Ile Thr His Ala 
        115                 120                 125             


Met Ala His Lys Val Ile Lys Ala Ala Arg Ser Gln Gly Val Asp Cys 
    130                 135                 140                 


Leu Val Ala Pro Tyr Glu Ala Asp Ala Gln Leu Ala Tyr Leu Asn Lys 
145                 150                 155                 160 


Ala Gly Ile Val Gln Ala Ile Ile Thr Glu Asp Ser Asp Leu Leu Ala 
                165                 170                 175     


Phe Gly Cys Lys Lys Val Ile Leu Lys Met Asp Gln Phe Gly Asn Gly 
            180                 185                 190         


Leu Glu Ile Asp Gln Ala Arg Leu Gly Met Cys Arg Gln Leu Gly Asp 
        195                 200                 205             


Val Phe Thr Glu Glu Lys Phe Arg Tyr Met Cys Ile Leu Ser Gly Cys 
    210                 215                 220                 


Asp Tyr Leu Ser Ser Leu Arg Gly Ile Gly Leu Ala Lys Ala Cys Lys 
225                 230                 235                 240 


Val Leu Arg Leu Ala Asn Asn Pro Asp Ile Val Lys Val Ile Lys Lys 
                245                 250                 255     


Ile Gly His Tyr Leu Lys Met Asn Ile Thr Val Pro Glu Asp Tyr Ile 
            260                 265                 270         


Asn Gly Phe Ile Arg Ala Asn Asn Thr Phe Leu Tyr Gln Leu Val Phe 
        275                 280                 285             


Asp Pro Ile Lys Arg Lys Leu Ile Pro Leu Asn Ala Tyr Glu Asp Asp 
    290                 295                 300                 


Val Asp Pro Glu Thr Leu Ser Tyr Ala Gly Gln Tyr Val Asp Asp Ser 
305                 310                 315                 320 


Ile Ala Leu Gln Ile Ala Leu Gly Asn Lys Asp Ile Asn Thr Phe Glu 
                325                 330                 335     


Gln Ile Asp Asp Tyr Asn Pro Asp Thr Ala Met Pro Ala His Ser Arg 
            340                 345                 350         


Ser His Ser Trp Asp Asp Lys Thr Cys Gln Lys Ser Ala Asn Val Ser 
        355                 360                 365             


Ser Ile Trp His Arg Asn Tyr Ser Pro Arg Pro Glu Ser Gly Thr Val 
    370                 375                 380                 


Ser Asp Ala Pro Gln Leu Lys Glu Asn Pro Ser Thr Val Gly Val Glu 
385                 390                 395                 400 


Arg Val Ile Ser Thr Lys Gly Leu Asn Leu Pro Arg Lys Ser Ser Ile 
                405                 410                 415     


Val Lys Arg Pro Arg Ser Ala Glu Leu Ser Glu Asp Asp Leu Leu Ser 
            420                 425                 430         


Gln Tyr Ser Leu Ser Phe Thr Lys Lys Thr Lys Lys Asn Ser Ser Glu 
        435                 440                 445             


Gly Asn Lys Ser Leu Ser Phe Ser Glu Val Phe Val Pro Asp Leu Val 
    450                 455                 460                 


Asn Gly Pro Thr Asn Lys Lys Ser Val Ser Thr Pro Pro Arg Thr Arg 
465                 470                 475                 480 


Asn Lys Phe Ala Thr Phe Leu Gln Arg Lys Asn Glu Glu Ser Gly Ala 
                485                 490                 495     


Val Val Val Pro Gly Thr Arg Ser Arg Phe Phe Cys Ser Ser Asp Ser 
            500                 505                 510         


Thr Asp Cys Val Ser Asn Lys Val Ser Ile Gln Pro Leu Asp Glu Thr 
        515                 520                 525             


Ala Val Thr Asp Lys Glu Asn Asn Leu His Glu Ser Glu Tyr Gly Asp 
    530                 535                 540                 


Gln Glu Gly Lys Arg Leu Val Asp Thr Asp Val Ala Arg Asn Ser Ser 
545                 550                 555                 560 


Asp Asp Ile Pro Asn Asn His Ile Pro Gly Asp His Ile Pro Asp Lys 
                565                 570                 575     


Ala Thr Val Phe Thr Asp Glu Glu Ser Tyr Ser Phe Glu Ser Ser Lys 
            580                 585                 590         


Phe Thr Arg Thr Ile Ser Pro Pro Thr Leu Gly Thr Leu Arg Ser Cys 
        595                 600                 605             


Phe Ser Trp Ser Gly Gly Leu Gly Asp Phe Ser Arg Thr Pro Ser Pro 
    610                 615                 620                 


Ser Pro Ser Thr Ala Leu Gln Gln Phe Arg Arg Lys Ser Asp Ser Pro 
625                 630                 635                 640 


Thr Ser Leu Pro Glu Asn Asn Met Ser Asp Val Ser Gln Leu Lys Ser 
                645                 650                 655     


Glu Glu Ser Ser Asp Asp Glu Ser His Pro Leu Arg Glu Glu Ala Cys 
            660                 665                 670         


Ser Ser Gln Ser Gln Glu Ser Gly Glu Phe Ser Leu Gln Ser Ser Asn 
        675                 680                 685             


Ala Ser Lys Leu Ser Gln Cys Ser Ser Lys Asp Ser Asp Ser Glu Glu 
    690                 695                 700                 


Ser Asp Cys Asn Ile Lys Leu Leu Asp Ser Gln Ser Asp Gln Thr Ser 
705                 710                 715                 720 


Lys Leu Arg Leu Ser His Phe Ser Lys Lys Asp Thr Pro Leu Arg Asn 
                725                 730                 735     


Lys Val Pro Gly Leu Tyr Lys Ser Ser Ser Ala Asp Ser Leu Ser Thr 
            740                 745                 750         


Thr Lys Ile Lys Pro Leu Gly Pro Ala Arg Ala Ser Gly Leu Ser Lys 
        755                 760                 765             


Lys Pro Ala Ser Ile Gln Lys Arg Lys His His Asn Ala Glu Asn Lys 
    770                 775                 780                 


Pro Gly Leu Gln Ile Lys Leu Asn Glu Leu Trp Lys Asn Phe Gly Phe 
785                 790                 795                 800 


Lys Lys Asp Ser Glu Lys Leu Pro Pro Cys Lys Lys Pro Leu Ser Pro 
                805                 810                 815     


Val Arg Asp Asn Ile Gln Leu Thr Pro Glu Ala Glu Glu Asp Ile Phe 
            820                 825                 830         


Asn Lys Pro Glu Cys Gly Arg Val Gln Arg Ala Ile Phe Gln 
        835                 840                 845     


<210>  136
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  136
gctcagcagg cacctgcctc agc                                               23


<210>  137
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  137
ctgatggtcc atgtctgtta ctc                                               23


<210>  138
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  138
tttggctcac tcctgctcgg tgaattt                                           27


<210>  139
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  139
tttcgcgctt gttccaatca gtacgca                                           27


<210>  140
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  140
gagtccgagc agaagaagaa                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  141
gcattttcag gaggaagcga                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  142
gtcatcttag tcattacctg                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  143
ggaatccctt ctgcagcacc                                                   20


<210>  144
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  144
acgtactgat gttaacagct ga                                                22


<210>  145
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  145
ggtcagctgt taacatcagt ac                                                22


<210>  146
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  146
tccagcccgc tggccctgta aa                                                22


<210>  147
<211>  174
<212>  PRT
<213>  Escherichia phage Mu

<400>  147

Met Ala Lys Pro Ala Lys Arg Ile Lys Ser Ala Ala Ala Ala Tyr Val 
1               5                   10                  15      


Pro Gln Asn Arg Asp Ala Val Ile Thr Asp Ile Lys Arg Ile Gly Asp 
            20                  25                  30          


Leu Gln Arg Glu Ala Ser Arg Leu Glu Thr Glu Met Asn Asp Ala Ile 
        35                  40                  45              


Ala Glu Ile Thr Glu Lys Phe Ala Ala Arg Ile Ala Pro Ile Lys Thr 
    50                  55                  60                  


Asp Ile Glu Thr Leu Ser Lys Gly Val Gln Gly Trp Cys Glu Ala Asn 
65                  70                  75                  80  


Arg Asp Glu Leu Thr Asn Gly Gly Lys Val Lys Thr Ala Asn Leu Val 
                85                  90                  95      


Thr Gly Asp Val Ser Trp Arg Val Arg Pro Pro Ser Val Ser Ile Arg 
            100                 105                 110         


Gly Met Asp Ala Val Met Glu Thr Leu Glu Arg Leu Gly Leu Gln Arg 
        115                 120                 125             


Phe Ile Arg Thr Lys Gln Glu Ile Asn Lys Glu Ala Ile Leu Leu Glu 
    130                 135                 140                 


Pro Lys Ala Val Ala Gly Val Ala Gly Ile Thr Val Lys Ser Gly Ile 
145                 150                 155                 160 


Glu Asp Phe Ser Ile Ile Pro Phe Glu Gln Glu Ala Gly Ile 
                165                 170                 


<210>  148
<211>  1228
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic LbCas12a H759A

<400>  148

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  149
<211>  1307
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic EnAsCas12a H800A

<400>  149

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Arg Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Arg Gly Trp 
    530                 535                 540                 


Asp Val Asn Arg Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala Ala 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  150
<211>  1307
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic EnAsCas12a

<400>  150

Met Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln 
            20                  25                  30          


Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys 
        35                  40                  45              


Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln 
    50                  55                  60                  


Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile 
65                  70                  75                  80  


Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile 
                85                  90                  95      


Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly 
            100                 105                 110         


Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile 
        115                 120                 125             


Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys 
    130                 135                 140                 


Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg 
145                 150                 155                 160 


Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Arg Asn Arg 
                165                 170                 175     


Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg 
            180                 185                 190         


Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe 
        195                 200                 205             


Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn 
    210                 215                 220                 


Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val 
225                 230                 235                 240 


Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp 
                245                 250                 255     


Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu 
            260                 265                 270         


Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn 
        275                 280                 285             


Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro 
    290                 295                 300                 


Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu 
305                 310                 315                 320 


Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr 
                325                 330                 335     


Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu 
            340                 345                 350         


Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His 
        355                 360                 365             


Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr 
    370                 375                 380                 


Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys 
385                 390                 395                 400 


Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu 
                405                 410                 415     


Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser 
            420                 425                 430         


Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala 
        435                 440                 445             


Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys 
    450                 455                 460                 


Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu 
465                 470                 475                 480 


Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe 
                485                 490                 495     


Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser 
            500                 505                 510         


Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val 
        515                 520                 525             


Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Arg Gly Trp 
    530                 535                 540                 


Asp Val Asn Arg Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn 
545                 550                 555                 560 


Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys 
                565                 570                 575     


Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys 
            580                 585                 590         


Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys 
        595                 600                 605             


Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr 
    610                 615                 620                 


Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys 
625                 630                 635                 640 


Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln 
                645                 650                 655     


Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala 
            660                 665                 670         


Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr 
        675                 680                 685             


Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr 
    690                 695                 700                 


Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His 
705                 710                 715                 720 


Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu 
                725                 730                 735     


Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys 
            740                 745                 750         


Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu 
        755                 760                 765             


Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln 
    770                 775                 780                 


Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His 
785                 790                 795                 800 


Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr 
                805                 810                 815     


Pro Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His 
            820                 825                 830         


Arg Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn 
        835                 840                 845             


Val Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe 
    850                 855                 860                 


Thr Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln 
865                 870                 875                 880 


Ala Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu 
                885                 890                 895     


Lys Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg 
            900                 905                 910         


Asn Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu 
        915                 920                 925             


Gln Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu 
    930                 935                 940                 


Asp Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val 
945                 950                 955                 960 


Val Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile 
                965                 970                 975     


His Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu 
            980                 985                 990         


Glu Asn Leu Asn Phe Gly Phe Lys  Ser Lys Arg Thr Gly  Ile Ala Glu 
        995                 1000                 1005             


Lys Ala  Val Tyr Gln Gln Phe  Glu Lys Met Leu Ile  Asp Lys Leu 
    1010                 1015                 1020             


Asn Cys  Leu Val Leu Lys Asp  Tyr Pro Ala Glu Lys  Val Gly Gly 
    1025                 1030                 1035             


Val Leu  Asn Pro Tyr Gln Leu  Thr Asp Gln Phe Thr  Ser Phe Ala 
    1040                 1045                 1050             


Lys Met  Gly Thr Gln Ser Gly  Phe Leu Phe Tyr Val  Pro Ala Pro 
    1055                 1060                 1065             


Tyr Thr  Ser Lys Ile Asp Pro  Leu Thr Gly Phe Val  Asp Pro Phe 
    1070                 1075                 1080             


Val Trp  Lys Thr Ile Lys Asn  His Glu Ser Arg Lys  His Phe Leu 
    1085                 1090                 1095             


Glu Gly  Phe Asp Phe Leu His  Tyr Asp Val Lys Thr  Gly Asp Phe 
    1100                 1105                 1110             


Ile Leu  His Phe Lys Met Asn  Arg Asn Leu Ser Phe  Gln Arg Gly 
    1115                 1120                 1125             


Leu Pro  Gly Phe Met Pro Ala  Trp Asp Ile Val Phe  Glu Lys Asn 
    1130                 1135                 1140             


Glu Thr  Gln Phe Asp Ala Lys  Gly Thr Pro Phe Ile  Ala Gly Lys 
    1145                 1150                 1155             


Arg Ile  Val Pro Val Ile Glu  Asn His Arg Phe Thr  Gly Arg Tyr 
    1160                 1165                 1170             


Arg Asp  Leu Tyr Pro Ala Asn  Glu Leu Ile Ala Leu  Leu Glu Glu 
    1175                 1180                 1185             


Lys Gly  Ile Val Phe Arg Asp  Gly Ser Asn Ile Leu  Pro Lys Leu 
    1190                 1195                 1200             


Leu Glu  Asn Asp Asp Ser His  Ala Ile Asp Thr Met  Val Ala Leu 
    1205                 1210                 1215             


Ile Arg  Ser Val Leu Gln Met  Arg Asn Ser Asn Ala  Ala Thr Gly 
    1220                 1225                 1230             


Glu Asp  Tyr Ile Asn Ser Pro  Val Arg Asp Leu Asn  Gly Val Cys 
    1235                 1240                 1245             


Phe Asp  Ser Arg Phe Gln Asn  Pro Glu Trp Pro Met  Asp Ala Asp 
    1250                 1255                 1260             


Ala Asn  Gly Ala Tyr His Ile  Ala Leu Lys Gly Gln  Leu Leu Leu 
    1265                 1270                 1275             


Asn His  Leu Lys Glu Ser Lys  Asp Leu Lys Leu Gln  Asn Gly Ile 
    1280                 1285                 1290             


Ser Asn  Gln Asp Trp Leu Ala  Tyr Ile Gln Glu Leu  Arg Asn 
    1295                 1300                 1305         


<210>  151
<211>  1107
<212>  PRT
<213>  Bacillus hisashii

<400>  151

Ala Thr Arg Ser Phe Ile Leu Lys Ile Glu Pro Asn Glu Glu Val Lys 
1               5                   10                  15      


Lys Gly Leu Trp Lys Thr His Glu Val Leu Asn His Gly Ile Ala Tyr 
            20                  25                  30          


Tyr Met Asn Ile Leu Lys Leu Ile Arg Gln Glu Ala Ile Tyr Glu His 
        35                  40                  45              


His Glu Gln Asp Pro Lys Asn Pro Lys Lys Val Ser Lys Ala Glu Ile 
    50                  55                  60                  


Gln Ala Glu Leu Trp Asp Phe Val Leu Lys Met Gln Lys Cys Asn Ser 
65                  70                  75                  80  


Phe Thr His Glu Val Asp Lys Asp Glu Val Phe Asn Ile Leu Arg Glu 
                85                  90                  95      


Leu Tyr Glu Glu Leu Val Pro Ser Ser Val Glu Lys Lys Gly Glu Ala 
            100                 105                 110         


Asn Gln Leu Ser Asn Lys Phe Leu Tyr Pro Leu Val Asp Pro Asn Ser 
        115                 120                 125             


Gln Ser Gly Lys Gly Thr Ala Ser Ser Gly Arg Lys Pro Arg Trp Tyr 
    130                 135                 140                 


Asn Leu Lys Ile Ala Gly Asp Pro Ser Trp Glu Glu Glu Lys Lys Lys 
145                 150                 155                 160 


Trp Glu Glu Asp Lys Lys Lys Asp Pro Leu Ala Lys Ile Leu Gly Lys 
                165                 170                 175     


Leu Ala Glu Tyr Gly Leu Ile Pro Leu Phe Ile Pro Tyr Thr Asp Ser 
            180                 185                 190         


Asn Glu Pro Ile Val Lys Glu Ile Lys Trp Met Glu Lys Ser Arg Asn 
        195                 200                 205             


Gln Ser Val Arg Arg Leu Asp Lys Asp Met Phe Ile Gln Ala Leu Glu 
    210                 215                 220                 


Arg Phe Leu Ser Trp Glu Ser Trp Asn Leu Lys Val Lys Glu Glu Tyr 
225                 230                 235                 240 


Glu Lys Val Glu Lys Glu Tyr Lys Thr Leu Glu Glu Arg Ile Lys Glu 
                245                 250                 255     


Asp Ile Gln Ala Leu Lys Ala Leu Glu Gln Tyr Glu Lys Glu Arg Gln 
            260                 265                 270         


Glu Gln Leu Leu Arg Asp Thr Leu Asn Thr Asn Glu Tyr Arg Leu Ser 
        275                 280                 285             


Lys Arg Gly Leu Arg Gly Trp Arg Glu Ile Ile Gln Lys Trp Leu Lys 
    290                 295                 300                 


Met Asp Glu Asn Glu Pro Ser Glu Lys Tyr Leu Glu Val Phe Lys Asp 
305                 310                 315                 320 


Tyr Gln Arg Lys His Pro Arg Glu Ala Gly Asp Tyr Ser Val Tyr Glu 
                325                 330                 335     


Phe Leu Ser Lys Lys Glu Asn His Phe Ile Trp Arg Asn His Pro Glu 
            340                 345                 350         


Tyr Pro Tyr Leu Tyr Ala Thr Phe Cys Glu Ile Asp Lys Lys Lys Lys 
        355                 360                 365             


Asp Ala Lys Gln Gln Ala Thr Phe Thr Leu Ala Asp Pro Ile Asn His 
    370                 375                 380                 


Pro Leu Trp Val Arg Phe Glu Glu Arg Ser Gly Ser Asn Leu Asn Lys 
385                 390                 395                 400 


Tyr Arg Ile Leu Thr Glu Gln Leu His Thr Glu Lys Leu Lys Lys Lys 
                405                 410                 415     


Leu Thr Val Gln Leu Asp Arg Leu Ile Tyr Pro Thr Glu Ser Gly Gly 
            420                 425                 430         


Trp Glu Glu Lys Gly Lys Val Asp Ile Val Leu Leu Pro Ser Arg Gln 
        435                 440                 445             


Phe Tyr Asn Gln Ile Phe Leu Asp Ile Glu Glu Lys Gly Lys His Ala 
    450                 455                 460                 


Phe Thr Tyr Lys Asp Glu Ser Ile Lys Phe Pro Leu Lys Gly Thr Leu 
465                 470                 475                 480 


Gly Gly Ala Arg Val Gln Phe Asp Arg Asp His Leu Arg Arg Tyr Pro 
                485                 490                 495     


His Lys Val Glu Ser Gly Asn Val Gly Arg Ile Tyr Phe Asn Met Thr 
            500                 505                 510         


Val Asn Ile Glu Pro Thr Glu Ser Pro Val Ser Lys Ser Leu Lys Ile 
        515                 520                 525             


His Arg Asp Asp Phe Pro Lys Val Val Asn Phe Lys Pro Lys Glu Leu 
    530                 535                 540                 


Thr Glu Trp Ile Lys Asp Ser Lys Gly Lys Lys Leu Lys Ser Gly Ile 
545                 550                 555                 560 


Glu Ser Leu Glu Ile Gly Leu Arg Val Met Ser Ile Asp Leu Gly Gln 
                565                 570                 575     


Arg Gln Ala Ala Ala Ala Ser Ile Phe Glu Val Val Asp Gln Lys Pro 
            580                 585                 590         


Asp Ile Glu Gly Lys Leu Phe Phe Pro Ile Lys Gly Thr Glu Leu Tyr 
        595                 600                 605             


Ala Val His Arg Ala Ser Phe Asn Ile Lys Leu Pro Gly Glu Thr Leu 
    610                 615                 620                 


Val Lys Ser Arg Glu Val Leu Arg Lys Ala Arg Glu Asp Asn Leu Lys 
625                 630                 635                 640 


Leu Met Asn Gln Lys Leu Asn Phe Leu Arg Asn Val Leu His Phe Gln 
                645                 650                 655     


Gln Phe Glu Asp Ile Thr Glu Arg Glu Lys Arg Val Thr Lys Trp Ile 
            660                 665                 670         


Ser Arg Gln Glu Asn Ser Asp Val Pro Leu Val Tyr Gln Asp Glu Leu 
        675                 680                 685             


Ile Gln Ile Arg Glu Leu Met Tyr Lys Pro Tyr Lys Asp Trp Val Ala 
    690                 695                 700                 


Phe Leu Lys Gln Leu His Lys Arg Leu Glu Val Glu Ile Gly Lys Glu 
705                 710                 715                 720 


Val Lys His Trp Arg Lys Ser Leu Ser Asp Gly Arg Lys Gly Leu Tyr 
                725                 730                 735     


Gly Ile Ser Leu Lys Asn Ile Asp Glu Ile Asp Arg Thr Arg Lys Phe 
            740                 745                 750         


Leu Leu Arg Trp Ser Leu Arg Pro Thr Glu Pro Gly Glu Val Arg Arg 
        755                 760                 765             


Leu Glu Pro Gly Gln Arg Phe Ala Ile Asp Gln Leu Asn His Leu Asn 
    770                 775                 780                 


Ala Leu Lys Glu Asp Arg Leu Lys Lys Met Ala Asn Thr Ile Ile Met 
785                 790                 795                 800 


His Ala Leu Gly Tyr Cys Tyr Asp Val Arg Lys Lys Lys Trp Gln Ala 
                805                 810                 815     


Lys Asn Pro Ala Cys Gln Ile Ile Leu Phe Glu Asp Leu Ser Asn Tyr 
            820                 825                 830         


Asn Pro Tyr Gly Glu Arg Ser Arg Phe Glu Asn Ser Arg Leu Met Lys 
        835                 840                 845             


Trp Ser Arg Arg Glu Ile Pro Arg Gln Val Ala Leu Gln Gly Glu Ile 
    850                 855                 860                 


Tyr Gly Leu Gln Val Gly Glu Val Gly Ala Gln Phe Ser Ser Arg Phe 
865                 870                 875                 880 


His Ala Lys Thr Gly Ser Pro Gly Ile Arg Cys Arg Val Val Thr Lys 
                885                 890                 895     


Glu Lys Leu Gln Asp Asn Arg Phe Phe Lys Asn Leu Gln Arg Glu Gly 
            900                 905                 910         


Arg Leu Thr Leu Asp Lys Ile Ala Val Leu Lys Glu Gly Asp Leu Tyr 
        915                 920                 925             


Pro Asp Lys Gly Gly Glu Lys Phe Ile Ser Leu Ser Lys Asp Arg Lys 
    930                 935                 940                 


Cys Val Thr Thr His Ala Asp Ile Asn Ala Ala Gln Asn Leu Gln Lys 
945                 950                 955                 960 


Arg Phe Trp Thr Arg Thr His Gly Phe Tyr Lys Val Tyr Cys Lys Ala 
                965                 970                 975     


Tyr Gln Val Asp Gly Gln Thr Val Tyr Ile Pro Glu Ser Lys Asp Gln 
            980                 985                 990         


Lys Gln Lys Ile Ile Glu Glu Phe  Gly Glu Gly Tyr Phe  Ile Leu Lys 
        995                 1000                 1005             


Asp Gly  Val Tyr Glu Trp Val  Asn Ala Gly Lys Leu  Lys Ile Lys 
    1010                 1015                 1020             


Lys Gly  Ser Ser Lys Gln Ser  Ser Ser Glu Leu Val  Asp Ser Asp 
    1025                 1030                 1035             


Ile Leu  Lys Asp Ser Phe Asp  Leu Ala Ser Glu Leu  Lys Gly Glu 
    1040                 1045                 1050             


Lys Leu  Met Leu Tyr Arg Asp  Pro Ser Gly Asn Val  Phe Pro Ser 
    1055                 1060                 1065             


Asp Lys  Trp Met Ala Ala Gly  Val Phe Phe Gly Lys  Leu Glu Arg 
    1070                 1075                 1080             


Ile Leu  Ile Ser Lys Leu Thr  Asn Gln Tyr Ser Ile  Ser Thr Ile 
    1085                 1090                 1095             


Glu Asp  Asp Ser Ser Lys Gln  Ser Met 
    1100                 1105         


<210>  152
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Gly Ile Ile Asn Thr Leu Gln Lys Tyr Tyr Cys Arg Val Arg Gly 
1               5                   10                  15      


Gly Arg Cys Ala Val Leu Ser Cys Leu Pro Lys Glu Glu Gln Ile Gly 
            20                  25                  30          


Lys Cys Ser Thr Arg Gly Arg Lys Cys Cys Arg Arg Lys Lys 
        35                  40                  45      


<210>  153
<211>  90
<212>  PRT
<213>  Grapevine virus A

<400>  153

Met Asp Asp Pro Ser Phe Leu Thr Gly Arg Ser Thr Tyr Ala Lys Arg 
1               5                   10                  15      


Arg Arg Ala Arg Arg Met Asn Val Cys Lys Cys Gly Ala Ile Leu His 
            20                  25                  30          


Asn Asn Lys Asp Cys Arg Ser Ser Thr Ile Ser Gly His Lys Leu Asp 
        35                  40                  45              


Arg Leu Arg Phe Val Lys Glu Gly Arg Val Ala Leu Glu Gly Glu Thr 
    50                  55                  60                  


Pro Val Tyr Arg Thr Trp Val Lys Trp Val Glu Thr Glu Tyr His Ile 
65                  70                  75                  80  


Asn Ile Leu Glu Thr Ser Asp Asp Glu Glu 
                85                  90  


<210>  154
<211>  6048
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic N-terminally fused REDRAW editor

<400>  154
atggcaactt caagaaagag gcctagtgac ttggttcacg tattctctcc tccacgaaag       60

aaggctggtt cggctacatc aagaaagcgt cccagcgatt tagtgcatgt cttctctccg      120

ccaagaaaga aggccggatc cactctcaat atcgaagacg aacatcgttt acatgaaaca      180

tctaaagaac cggacgtttc tttaggttcc acatggttaa gcgacttccc tcaggcctgg      240

gcagaaacag gtggtatggg acttgccgtt cgacaagcgc ctttgatcat acccctaaag      300

gcgacaagta ccccagtatc cattaaacag tatcctatgt cccaggaggc acgcttgggg      360

ataaagcccc atatccaaag actattagat caggggatac ttgtcccatg ccaaagccct      420

tggaacactc cgttactgcc cgtgaaaaaa ccaggtacaa acgattatag acctgtgcaa      480

gacctgcgcg aggtgaacaa gagggtagag gatatacatc caacggttcc aaatccttat      540

aatttactat ctggtcttcc acctagtcac cagtggtata ccgtcttgga cttgaaggat      600

gcgtttttct gcttgcgttt acatccgacg tctcaacctt tattcgcatt cgagtggcga      660

gatcctgaga tgggtatctc tggtcagtta acttggacaa gattgcctca aggttttaag      720

aatagtccaa ctttatttaa tgaagccttg catagagatt tggctgattt taggattcaa      780

catcctgacc taattttgct acaatacgtt gatgatctat tgttggctgc cacctcggaa      840

cttgattgtc aacagggtac gagggctctg cttcaaacct taggaaactt gggataccga      900

gcttctgcta aaaaggcgca aatttgtcaa aagcaggtaa aatacttggg ttacctattg      960

aaagaagggc aaaggtggct aactgaggcc cgtaaagaaa ccgtgatggg tcaaccaacc     1020

cccaaaacac caagacaact cagggaattt ttaggcaaag cgggtttctg tagattgttt     1080

attcctggct ttgcagaaat ggccgcacca ctgtatccac tgacaaaacc aggcaccttg     1140

ttcaactggg gcccagatca gcagaaggct tatcaagaaa ttaaacaggc tttgctaaca     1200

gcaccagcac taggtctacc agatttaact aaacccttcg aattgtttgt tgatgaaaaa     1260

caaggatatg ctaaaggtgt cctgactcaa aaattgggac cctggagaag accggttgca     1320

tatttaagca aaaagttgga cccagtagcc gctgggtggc caccgtgttt aaggatggtt     1380

gctgctatcg ctgtcttaac gaaggatgcc ggcaaattaa cgatgggaca gccactggtt     1440

atactagctc cccatgctgt tgaagccttg gtgaaacaac ctcccgaccg ttggttatca     1500

aatgcaagaa tgacacacta tcaagccttg ttgctcgaca cagacagagt tcaatttgga     1560

cctgtagtcg cactaaatcc ggcgactctt ttaccactgc cagaagaggg tcttcaacat     1620

aactgcctcg atattttggc cgaagctcat gggaccagac cggacttaac agatcaacct     1680

ttaccagatg cagatcacac ttggtacact gatggtagtt cactccttca agagggtcaa     1740

cgtaaagctg gcgcagcagt taccactgaa acggaagtaa tttgggcaaa agcattacct     1800

gctggtactt cagcccaaag agctgagttg attgccttga ctcaagctct taaaatggct     1860

gaaggcaaga agctgaatgt ctatactgac tcaagatacg cttttgctac tgctcatatt     1920

cacggtgaaa tctacagaag aagaggatgg cttacgagtg aaggaaaaga aattaagaat     1980

aaggatgaga tattagcact tctcaaagca ttgtttctgc caaagagact ttcaattatt     2040

cactgtccag gacatcaaaa gggccactcc gccgaagcta ggggtaatag aatggcagat     2100

caggcagcga ggaaggctgc catcacagag actcctgata catctacctt attaatagaa     2160

aactcgtcgc caaattcacg gttaataaac tcaggtggat cgtccggtgg cagttctggt     2220

tcagaaactc ctggtacatc tgagagcgct accccagaat ccagtggagg gagctcaggg     2280

ggttctagca aactcgaaaa gttcactaat tgttactctc tatcaaagac cttaagattt     2340

aaggctatac ctgtagggaa gactcaagaa aacatcgata ataagaggtt gttagttgaa     2400

gatgaaaaga gggctgaaga ctacaagggt gtaaagaaat tgttggaccg atactacctt     2460

agcttcatca acgatgtctt gcattcaata aagttgaaaa atttaaataa ctacatctcg     2520

ctattccgta agaaaacgag gaccgaaaag gagaacaaag aactagaaaa cttggaaatc     2580

aacctgagaa aggagatagc caaagccttc aagggtaatg agggttacaa gtctcttttt     2640

aagaaagata ttatcgaaac tatactacca gaattcttag atgacaaaga cgagatcgcc     2700

ctggtaaact cttttaatgg tttcacaact gcgttcacag gtttctttga caatcgcgag     2760

aatatgttct ctgaagaggc taagagtaca tcaatcgcat tcaggtgcat caacgaaaac     2820

ttgacgaggt acatttcgaa catggacata tttgaaaagg ttgacgcaat cttcgacaag     2880

catgaagtac aagaaatcaa ggaaaagatc ttaaattcgg attacgatgt ggaggatttc     2940

ttcgaaggtg aattctttaa cttcgtcttg acccaagagg gtatcgatgt ctacaatgca     3000

atcataggag gtttcgttac cgaatccggc gagaagatca aaggtctaaa cgaatatatc     3060

aatctgtata atcaaaagac caagcagaaa ctacccaaat tcaagcctct ctacaagcaa     3120

gtcttgtcag acagggaatc cctatccttc tacggcgaag gatacacctc tgatgaagag     3180

gtgttggagg tcttccgtaa tactttgaat aagaactcag aaatcttttc ctctataaag     3240

aaactagaga aattattcaa gaatttcgac gaatactcta gtgcaggcat cttcgtgaag     3300

aatggtcctg ctataagcac aatctctaaa gatatcttcg gggaatggaa tgtcatccga     3360

gataagtgga atgcggaata cgatgatatc cacttaaaga aaaaggcagt tgtaaccgaa     3420

aaatacgaag atgacaggcg taagtcattc aagaagatcg gatcattcag tctcgaacag     3480

ttacaagagt acgccgacgc tgacctttct gtcgtggaaa agctaaaaga gattatcata     3540

cagaaagttg atgaaatata taaggtctat ggttcatcag aaaagttgtt cgatgctgat     3600

ttcgtattag aaaagagttt aaagaaaaac gacgctgtag tggcaatcat gaaggattta     3660

ttggacagtg tcaagtcatt tgaaaattac atcaaggcat tcttcggtga aggtaaggaa     3720

acaaaccgcg atgagtcctt ctacggagat ttcgtgttgg cctatgacat cctattaaag     3780

gtggatcaca tctatgatgc tatccgtaat tatgtcacac agaaacccta ctctaaggac     3840

aagttcaagt tgtacttcca gaacccacaa tttatgggtg gttgggataa ggataaggaa     3900

actgactaca gagcaactat cttaaggtat ggttcaaagt actatctcgc tatcatggac     3960

aagaaatacg ctaagtgtct acaaaagatc gacaaagatg atgtcaatgg taattacgag     4020

aagatcaatt acaaattact accaggacca aataagatgc ttccgaaggt gttcttttca     4080

aagaagtgga tggcgtatta caaccctagt gaagacatcc agaagatata taagaatggg     4140

accttcaaaa agggagatat gttcaatctg aatgattgtc acaaattaat cgatttcttt     4200

aaggacagta tctccagata cccgaagtgg tcaaatgctt acgattttaa cttctcggaa     4260

acagagaagt acaaagacat cgctggtttc tacagagaag tggaggagca gggttacaag     4320

gtgtcattcg aaagtgcaag caagaaggag gtagataagc tggtagagga gggcaagttg     4380

tatatgtttc aaatctataa caaggatttc tcggataagt ctcacggaac accaaactta     4440

catactatgt actttaagct cctgttcgat gaaaacaatc atgggcaaat cagattatct     4500

ggtggtgctg aattgttcat gagacgtgca agtttaaaga aggaggaatt ggttgtcgct     4560

ccagcaaata gcccaatcgc gaataagaat ccagacaacc caaagaaaac gacgacgttg     4620

tcgtacgatg tttacaagga taagagattc tcagaagatc aatatgagct gcatatccct     4680

atcgcaatca ataagtgtcc taagaacatt ttcaagatta acactgaagt tagagtgcta     4740

ctcaagcatg atgataaccc ctacgttatc ggcatagata gaggcgagag gaatttgtta     4800

tacatcgtcg tggtggatgg caagggaaac atcgttgagc agtattctct taatgaaatt     4860

atcaataatt tcaatggaat tagaatcaaa actgattatc actccctgtt ggacaagaag     4920

gaaaaggaaa gattcgaagc tagacagaac tggacttcca ttgaaaacat taaagagcta     4980

aaggctggtt atatctccca agttgttcat aagatctgcg agttagtgga aaagtatgat     5040

gctgtaatcg cccttgaaga tcttaactct ggtttcaaga attcaagagt caaggttgaa     5100

aagcaagtgt accagaaatt tgagaagatg ctgatagaca aattgaatta catggtagat     5160

aagaagtcca atccatgtgc caccggggga gccttaaagg ggtatcagat cacaaacaag     5220

ttcgaatctt tcaagtcgat gagcacacag aatgggttta tattctacat tccggcctgg     5280

ttaacttcta agattgatcc cagcaccggc ttcgttaatc tgttgaagac taagtacacg     5340

tctatcgccg acagcaagaa gttcatctct agctttgata gaattatgta cgttccagaa     5400

gaagatctgt tcgaattcgc tcttgactac aagaacttct ctcggacaga tgcagattac     5460

atcaagaaat ggaagttgta tagttacggc aatagaatcc gtatcttccg taaccctaag     5520

aagaacaacg tcttcgattg ggaagaagtt tgcttaacat ccgcatacaa ggaactgttt     5580

aataagtacg gaatcaatta ccaacaaggt gatattcgag cactgttgtg tgaacaatct     5640

gacaaggctt tctattcgag tttcatggca ttaatgtcac tgatgttgca aatgcggaat     5700

agtatcactg gtagaactga tgtggatttc cttatcagtc ctgttaagaa ctctgatgga     5760

attttctatg actccaggaa ttacgaagcc caagaaaatg ctatccttcc taagaatgcg     5820

gacgctaacg gcgcttacaa tattgcaaga aaggtgttgt gggccatagg tcagttcaag     5880

aaggccgaag atgaaaagtt agataaggta aagattgcga tcagtaataa ggagtggttg     5940

gaatacgccc aaacatccgt taagcatggt agttcaggag gtagcaagag gactgctgat     6000

gggtctgaat tcgagccaaa gaagaagaga aaggttggct ccggttaa                  6048


<210>  155
<211>  2015
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic N-terminally fused REDRAW editor

<400>  155

Met Ala Thr Ser Arg Lys Arg Pro Ser Asp Leu Val His Val Phe Ser 
1               5                   10                  15      


Pro Pro Arg Lys Lys Ala Gly Ser Ala Thr Ser Arg Lys Arg Pro Ser 
            20                  25                  30          


Asp Leu Val His Val Phe Ser Pro Pro Arg Lys Lys Ala Gly Ser Thr 
        35                  40                  45              


Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu Pro 
    50                  55                  60                  


Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp 
65                  70                  75                  80  


Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile 
                85                  90                  95      


Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro 
            100                 105                 110         


Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu 
        115                 120                 125             


Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro 
    130                 135                 140                 


Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln 
145                 150                 155                 160 


Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val 
                165                 170                 175     


Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp 
            180                 185                 190         


Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His 
        195                 200                 205             


Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met 
    210                 215                 220                 


Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys 
225                 230                 235                 240 


Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp 
                245                 250                 255     


Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp 
            260                 265                 270         


Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg 
        275                 280                 285             


Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys 
    290                 295                 300                 


Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu 
305                 310                 315                 320 


Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met 
                325                 330                 335     


Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly 
            340                 345                 350         


Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala 
        355                 360                 365             


Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly 
    370                 375                 380                 


Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr 
385                 390                 395                 400 


Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe 
                405                 410                 415     


Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu 
            420                 425                 430         


Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro 
        435                 440                 445             


Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala 
    450                 455                 460                 


Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val 
465                 470                 475                 480 


Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp 
                485                 490                 495     


Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu 
            500                 505                 510         


Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala 
        515                 520                 525             


Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp 
    530                 535                 540                 


Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro 
545                 550                 555                 560 


Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu Leu 
                565                 570                 575     


Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu 
            580                 585                 590         


Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala 
        595                 600                 605             


Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys 
    610                 615                 620                 


Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile 
625                 630                 635                 640 


His Gly Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly Lys 
                645                 650                 655     


Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe 
            660                 665                 670         


Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly 
        675                 680                 685             


His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg 
    690                 695                 700                 


Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile Glu 
705                 710                 715                 720 


Asn Ser Ser Pro Asn Ser Arg Leu Ile Asn Ser Gly Gly Ser Ser Gly 
                725                 730                 735     


Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 
            740                 745                 750         


Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Lys Leu Glu Lys Phe 
        755                 760                 765             


Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg Phe Lys Ala Ile Pro 
    770                 775                 780                 


Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys Arg Leu Leu Val Glu 
785                 790                 795                 800 


Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val Lys Lys Leu Leu Asp 
                805                 810                 815     


Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu His Ser Ile Lys Leu 
            820                 825                 830         


Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg Lys Lys Thr Arg Thr 
        835                 840                 845             


Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu Ile Asn Leu Arg Lys 
    850                 855                 860                 


Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly Tyr Lys Ser Leu Phe 
865                 870                 875                 880 


Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu Phe Leu Asp Asp Lys 
                885                 890                 895     


Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly Phe Thr Thr Ala Phe 
            900                 905                 910         


Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe Ser Glu Glu Ala Lys 
        915                 920                 925             


Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu Asn Leu Thr Arg Tyr 
    930                 935                 940                 


Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp Ala Ile Phe Asp Lys 
945                 950                 955                 960 


His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu Asn Ser Asp Tyr Asp 
                965                 970                 975     


Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn Phe Val Leu Thr Gln 
            980                 985                 990         


Glu Gly Ile Asp Val Tyr Asn Ala  Ile Ile Gly Gly Phe  Val Thr Glu 
        995                 1000                 1005             


Ser Gly  Glu Lys Ile Lys Gly  Leu Asn Glu Tyr Ile  Asn Leu Tyr 
    1010                 1015                 1020             


Asn Gln  Lys Thr Lys Gln Lys  Leu Pro Lys Phe Lys  Pro Leu Tyr 
    1025                 1030                 1035             


Lys Gln  Val Leu Ser Asp Arg  Glu Ser Leu Ser Phe  Tyr Gly Glu 
    1040                 1045                 1050             


Gly Tyr  Thr Ser Asp Glu Glu  Val Leu Glu Val Phe  Arg Asn Thr 
    1055                 1060                 1065             


Leu Asn  Lys Asn Ser Glu Ile  Phe Ser Ser Ile Lys  Lys Leu Glu 
    1070                 1075                 1080             


Lys Leu  Phe Lys Asn Phe Asp  Glu Tyr Ser Ser Ala  Gly Ile Phe 
    1085                 1090                 1095             


Val Lys  Asn Gly Pro Ala Ile  Ser Thr Ile Ser Lys  Asp Ile Phe 
    1100                 1105                 1110             


Gly Glu  Trp Asn Val Ile Arg  Asp Lys Trp Asn Ala  Glu Tyr Asp 
    1115                 1120                 1125             


Asp Ile  His Leu Lys Lys Lys  Ala Val Val Thr Glu  Lys Tyr Glu 
    1130                 1135                 1140             


Asp Asp  Arg Arg Lys Ser Phe  Lys Lys Ile Gly Ser  Phe Ser Leu 
    1145                 1150                 1155             


Glu Gln  Leu Gln Glu Tyr Ala  Asp Ala Asp Leu Ser  Val Val Glu 
    1160                 1165                 1170             


Lys Leu  Lys Glu Ile Ile Ile  Gln Lys Val Asp Glu  Ile Tyr Lys 
    1175                 1180                 1185             


Val Tyr  Gly Ser Ser Glu Lys  Leu Phe Asp Ala Asp  Phe Val Leu 
    1190                 1195                 1200             


Glu Lys  Ser Leu Lys Lys Asn  Asp Ala Val Val Ala  Ile Met Lys 
    1205                 1210                 1215             


Asp Leu  Leu Asp Ser Val Lys  Ser Phe Glu Asn Tyr  Ile Lys Ala 
    1220                 1225                 1230             


Phe Phe  Gly Glu Gly Lys Glu  Thr Asn Arg Asp Glu  Ser Phe Tyr 
    1235                 1240                 1245             


Gly Asp  Phe Val Leu Ala Tyr  Asp Ile Leu Leu Lys  Val Asp His 
    1250                 1255                 1260             


Ile Tyr  Asp Ala Ile Arg Asn  Tyr Val Thr Gln Lys  Pro Tyr Ser 
    1265                 1270                 1275             


Lys Asp  Lys Phe Lys Leu Tyr  Phe Gln Asn Pro Gln  Phe Met Gly 
    1280                 1285                 1290             


Gly Trp  Asp Lys Asp Lys Glu  Thr Asp Tyr Arg Ala  Thr Ile Leu 
    1295                 1300                 1305             


Arg Tyr  Gly Ser Lys Tyr Tyr  Leu Ala Ile Met Asp  Lys Lys Tyr 
    1310                 1315                 1320             


Ala Lys  Cys Leu Gln Lys Ile  Asp Lys Asp Asp Val  Asn Gly Asn 
    1325                 1330                 1335             


Tyr Glu  Lys Ile Asn Tyr Lys  Leu Leu Pro Gly Pro  Asn Lys Met 
    1340                 1345                 1350             


Leu Pro  Lys Val Phe Phe Ser  Lys Lys Trp Met Ala  Tyr Tyr Asn 
    1355                 1360                 1365             


Pro Ser  Glu Asp Ile Gln Lys  Ile Tyr Lys Asn Gly  Thr Phe Lys 
    1370                 1375                 1380             


Lys Gly  Asp Met Phe Asn Leu  Asn Asp Cys His Lys  Leu Ile Asp 
    1385                 1390                 1395             


Phe Phe  Lys Asp Ser Ile Ser  Arg Tyr Pro Lys Trp  Ser Asn Ala 
    1400                 1405                 1410             


Tyr Asp  Phe Asn Phe Ser Glu  Thr Glu Lys Tyr Lys  Asp Ile Ala 
    1415                 1420                 1425             


Gly Phe  Tyr Arg Glu Val Glu  Glu Gln Gly Tyr Lys  Val Ser Phe 
    1430                 1435                 1440             


Glu Ser  Ala Ser Lys Lys Glu  Val Asp Lys Leu Val  Glu Glu Gly 
    1445                 1450                 1455             


Lys Leu  Tyr Met Phe Gln Ile  Tyr Asn Lys Asp Phe  Ser Asp Lys 
    1460                 1465                 1470             


Ser His  Gly Thr Pro Asn Leu  His Thr Met Tyr Phe  Lys Leu Leu 
    1475                 1480                 1485             


Phe Asp  Glu Asn Asn His Gly  Gln Ile Arg Leu Ser  Gly Gly Ala 
    1490                 1495                 1500             


Glu Leu  Phe Met Arg Arg Ala  Ser Leu Lys Lys Glu  Glu Leu Val 
    1505                 1510                 1515             


Val Ala  Pro Ala Asn Ser Pro  Ile Ala Asn Lys Asn  Pro Asp Asn 
    1520                 1525                 1530             


Pro Lys  Lys Thr Thr Thr Leu  Ser Tyr Asp Val Tyr  Lys Asp Lys 
    1535                 1540                 1545             


Arg Phe  Ser Glu Asp Gln Tyr  Glu Leu His Ile Pro  Ile Ala Ile 
    1550                 1555                 1560             


Asn Lys  Cys Pro Lys Asn Ile  Phe Lys Ile Asn Thr  Glu Val Arg 
    1565                 1570                 1575             


Val Leu  Leu Lys His Asp Asp  Asn Pro Tyr Val Ile  Gly Ile Asp 
    1580                 1585                 1590             


Arg Gly  Glu Arg Asn Leu Leu  Tyr Ile Val Val Val  Asp Gly Lys 
    1595                 1600                 1605             


Gly Asn  Ile Val Glu Gln Tyr  Ser Leu Asn Glu Ile  Ile Asn Asn 
    1610                 1615                 1620             


Phe Asn  Gly Ile Arg Ile Lys  Thr Asp Tyr His Ser  Leu Leu Asp 
    1625                 1630                 1635             


Lys Lys  Glu Lys Glu Arg Phe  Glu Ala Arg Gln Asn  Trp Thr Ser 
    1640                 1645                 1650             


Ile Glu  Asn Ile Lys Glu Leu  Lys Ala Gly Tyr Ile  Ser Gln Val 
    1655                 1660                 1665             


Val His  Lys Ile Cys Glu Leu  Val Glu Lys Tyr Asp  Ala Val Ile 
    1670                 1675                 1680             


Ala Leu  Glu Asp Leu Asn Ser  Gly Phe Lys Asn Ser  Arg Val Lys 
    1685                 1690                 1695             


Val Glu  Lys Gln Val Tyr Gln  Lys Phe Glu Lys Met  Leu Ile Asp 
    1700                 1705                 1710             


Lys Leu  Asn Tyr Met Val Asp  Lys Lys Ser Asn Pro  Cys Ala Thr 
    1715                 1720                 1725             


Gly Gly  Ala Leu Lys Gly Tyr  Gln Ile Thr Asn Lys  Phe Glu Ser 
    1730                 1735                 1740             


Phe Lys  Ser Met Ser Thr Gln  Asn Gly Phe Ile Phe  Tyr Ile Pro 
    1745                 1750                 1755             


Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser Thr Gly  Phe Val Asn 
    1760                 1765                 1770             


Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala Asp Ser  Lys Lys Phe 
    1775                 1780                 1785             


Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val Pro Glu  Glu Asp Leu 
    1790                 1795                 1800             


Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe Ser Arg  Thr Asp Ala 
    1805                 1810                 1815             


Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser Tyr Gly  Asn Arg Ile 
    1820                 1825                 1830             


Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn Val Phe  Asp Trp Glu 
    1835                 1840                 1845             


Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu Leu Phe  Asn Lys Tyr 
    1850                 1855                 1860             


Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg Ala Leu  Leu Cys Glu 
    1865                 1870                 1875             


Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe Met Ala  Leu Met Ser 
    1880                 1885                 1890             


Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr Gly Arg  Thr Asp Val 
    1895                 1900                 1905             


Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser Asp Gly  Ile Phe Tyr 
    1910                 1915                 1920             


Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn Ala Ile  Leu Pro Lys 
    1925                 1930                 1935             


Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile Ala Arg  Lys Val Leu 
    1940                 1945                 1950             


Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu Asp Glu  Lys Leu Asp 
    1955                 1960                 1965             


Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu Trp Leu  Glu Tyr Ala 
    1970                 1975                 1980             


Gln Thr  Ser Val Lys His Gly  Ser Ser Gly Gly Ser  Lys Arg Thr 
    1985                 1990                 1995             


Ala Asp  Gly Ser Glu Phe Glu  Pro Lys Lys Lys Arg  Lys Val Gly 
    2000                 2005                 2010             


Ser Gly  
    2015 


<210>  156
<211>  6048
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic C-terminally fused REDRAW Editor

<400>  156
atggcaactt caagaaagag gcctagtgac ttggttcacg tattctctcc tccacgaaag       60

aaggctggtt cggctacatc aagaaagcgt cccagcgatt tagtgcatgt cttctctccg      120

ccaagaaaga aggccggatc cagcaaactc gaaaagttca ctaattgtta ctctctatca      180

aagaccttaa gatttaaggc tatacctgta gggaagactc aagaaaacat cgataataag      240

aggttgttag ttgaagatga aaagagggct gaagactaca agggtgtaaa gaaattgttg      300

gaccgatact accttagctt catcaacgat gtcttgcatt caataaagtt gaaaaattta      360

aataactaca tctcgctatt ccgtaagaaa acgaggaccg aaaaggagaa caaagaacta      420

gaaaacttgg aaatcaacct gagaaaggag atagccaaag ccttcaaggg taatgagggt      480

tacaagtctc tttttaagaa agatattatc gaaactatac taccagaatt cttagatgac      540

aaagacgaga tcgccctggt aaactctttt aatggtttca caactgcgtt cacaggtttc      600

tttgacaatc gcgagaatat gttctctgaa gaggctaaga gtacatcaat cgcattcagg      660

tgcatcaacg aaaacttgac gaggtacatt tcgaacatgg acatatttga aaaggttgac      720

gcaatcttcg acaagcatga agtacaagaa atcaaggaaa agatcttaaa ttcggattac      780

gatgtggagg atttcttcga aggtgaattc tttaacttcg tcttgaccca agagggtatc      840

gatgtctaca atgcaatcat aggaggtttc gttaccgaat ccggcgagaa gatcaaaggt      900

ctaaacgaat atatcaatct gtataatcaa aagaccaagc agaaactacc caaattcaag      960

cctctctaca agcaagtctt gtcagacagg gaatccctat ccttctacgg cgaaggatac     1020

acctctgatg aagaggtgtt ggaggtcttc cgtaatactt tgaataagaa ctcagaaatc     1080

ttttcctcta taaagaaact agagaaatta ttcaagaatt tcgacgaata ctctagtgca     1140

ggcatcttcg tgaagaatgg tcctgctata agcacaatct ctaaagatat cttcggggaa     1200

tggaatgtca tccgagataa gtggaatgcg gaatacgatg atatccactt aaagaaaaag     1260

gcagttgtaa ccgaaaaata cgaagatgac aggcgtaagt cattcaagaa gatcggatca     1320

ttcagtctcg aacagttaca agagtacgcc gacgctgacc tttctgtcgt ggaaaagcta     1380

aaagagatta tcatacagaa agttgatgaa atatataagg tctatggttc atcagaaaag     1440

ttgttcgatg ctgatttcgt attagaaaag agtttaaaga aaaacgacgc tgtagtggca     1500

atcatgaagg atttattgga cagtgtcaag tcatttgaaa attacatcaa ggcattcttc     1560

ggtgaaggta aggaaacaaa ccgcgatgag tccttctacg gagatttcgt gttggcctat     1620

gacatcctat taaaggtgga tcacatctat gatgctatcc gtaattatgt cacacagaaa     1680

ccctactcta aggacaagtt caagttgtac ttccagaacc cacaatttat gggtggttgg     1740

gataaggata aggaaactga ctacagagca actatcttaa ggtatggttc aaagtactat     1800

ctcgctatca tggacaagaa atacgctaag tgtctacaaa agatcgacaa agatgatgtc     1860

aatggtaatt acgagaagat caattacaaa ttactaccag gaccaaataa gatgcttccg     1920

aaggtgttct tttcaaagaa gtggatggcg tattacaacc ctagtgaaga catccagaag     1980

atatataaga atgggacctt caaaaaggga gatatgttca atctgaatga ttgtcacaaa     2040

ttaatcgatt tctttaagga cagtatctcc agatacccga agtggtcaaa tgcttacgat     2100

tttaacttct cggaaacaga gaagtacaaa gacatcgctg gtttctacag agaagtggag     2160

gagcagggtt acaaggtgtc attcgaaagt gcaagcaaga aggaggtaga taagctggta     2220

gaggagggca agttgtatat gtttcaaatc tataacaagg atttctcgga taagtctcac     2280

ggaacaccaa acttacatac tatgtacttt aagctcctgt tcgatgaaaa caatcatggg     2340

caaatcagat tatctggtgg tgctgaattg ttcatgagac gtgcaagttt aaagaaggag     2400

gaattggttg tcgctccagc aaatagccca atcgcgaata agaatccaga caacccaaag     2460

aaaacgacga cgttgtcgta cgatgtttac aaggataaga gattctcaga agatcaatat     2520

gagctgcata tccctatcgc aatcaataag tgtcctaaga acattttcaa gattaacact     2580

gaagttagag tgctactcaa gcatgatgat aacccctacg ttatcggcat agatagaggc     2640

gagaggaatt tgttatacat cgtcgtggtg gatggcaagg gaaacatcgt tgagcagtat     2700

tctcttaatg aaattatcaa taatttcaat ggaattagaa tcaaaactga ttatcactcc     2760

ctgttggaca agaaggaaaa ggaaagattc gaagctagac agaactggac ttccattgaa     2820

aacattaaag agctaaaggc tggttatatc tcccaagttg ttcataagat ctgcgagtta     2880

gtggaaaagt atgatgctgt aatcgccctt gaagatctta actctggttt caagaattca     2940

agagtcaagg ttgaaaagca agtgtaccag aaatttgaga agatgctgat agacaaattg     3000

aattacatgg tagataagaa gtccaatcca tgtgccaccg ggggagcctt aaaggggtat     3060

cagatcacaa acaagttcga atctttcaag tcgatgagca cacagaatgg gtttatattc     3120

tacattccgg cctggttaac ttctaagatt gatcccagca ccggcttcgt taatctgttg     3180

aagactaagt acacgtctat cgccgacagc aagaagttca tctctagctt tgatagaatt     3240

atgtacgttc cagaagaaga tctgttcgaa ttcgctcttg actacaagaa cttctctcgg     3300

acagatgcag attacatcaa gaaatggaag ttgtatagtt acggcaatag aatccgtatc     3360

ttccgtaacc ctaagaagaa caacgtcttc gattgggaag aagtttgctt aacatccgca     3420

tacaaggaac tgtttaataa gtacggaatc aattaccaac aaggtgatat tcgagcactg     3480

ttgtgtgaac aatctgacaa ggctttctat tcgagtttca tggcattaat gtcactgatg     3540

ttgcaaatgc ggaatagtat cactggtaga actgatgtgg atttccttat cagtcctgtt     3600

aagaactctg atggaatttt ctatgactcc aggaattacg aagcccaaga aaatgctatc     3660

cttcctaaga atgcggacgc taacggcgct tacaatattg caagaaaggt gttgtgggcc     3720

ataggtcagt tcaagaaggc cgaagatgaa aagttagata aggtaaagat tgcgatcagt     3780

aataaggagt ggttggaata cgcccaaaca tccgttaagc attcaggtgg atcgtccggt     3840

ggcagttctg gttcagaaac tcctggtaca tctgagagcg ctaccccaga atccagtgga     3900

gggagctcag ggggttctac tctcaatatc gaagacgaac atcgtttaca tgaaacatct     3960

aaagaaccgg acgtttcttt aggttccaca tggttaagcg acttccctca ggcctgggca     4020

gaaacaggtg gtatgggact tgccgttcga caagcgcctt tgatcatacc cctaaaggcg     4080

acaagtaccc cagtatccat taaacagtat cctatgtccc aggaggcacg cttggggata     4140

aagccccata tccaaagact attagatcag gggatacttg tcccatgcca aagcccttgg     4200

aacactccgt tactgcccgt gaaaaaacca ggtacaaacg attatagacc tgtgcaagac     4260

ctgcgcgagg tgaacaagag ggtagaggat atacatccaa cggttccaaa tccttataat     4320

ttactatctg gtcttccacc tagtcaccag tggtataccg tcttggactt gaaggatgcg     4380

tttttctgct tgcgtttaca tccgacgtct caacctttat tcgcattcga gtggcgagat     4440

cctgagatgg gtatctctgg tcagttaact tggacaagat tgcctcaagg ttttaagaat     4500

agtccaactt tatttaatga agccttgcat agagatttgg ctgattttag gattcaacat     4560

cctgacctaa ttttgctaca atacgttgat gatctattgt tggctgccac ctcggaactt     4620

gattgtcaac agggtacgag ggctctgctt caaaccttag gaaacttggg ataccgagct     4680

tctgctaaaa aggcgcaaat ttgtcaaaag caggtaaaat acttgggtta cctattgaaa     4740

gaagggcaaa ggtggctaac tgaggcccgt aaagaaaccg tgatgggtca accaaccccc     4800

aaaacaccaa gacaactcag ggaattttta ggcaaagcgg gtttctgtag attgtttatt     4860

cctggctttg cagaaatggc cgcaccactg tatccactga caaaaccagg caccttgttc     4920

aactggggcc cagatcagca gaaggcttat caagaaatta aacaggcttt gctaacagca     4980

ccagcactag gtctaccaga tttaactaaa cccttcgaat tgtttgttga tgaaaaacaa     5040

ggatatgcta aaggtgtcct gactcaaaaa ttgggaccct ggagaagacc ggttgcatat     5100

ttaagcaaaa agttggaccc agtagccgct gggtggccac cgtgtttaag gatggttgct     5160

gctatcgctg tcttaacgaa ggatgccggc aaattaacga tgggacagcc actggttata     5220

ctagctcccc atgctgttga agccttggtg aaacaacctc ccgaccgttg gttatcaaat     5280

gcaagaatga cacactatca agccttgttg ctcgacacag acagagttca atttggacct     5340

gtagtcgcac taaatccggc gactctttta ccactgccag aagagggtct tcaacataac     5400

tgcctcgata ttttggccga agctcatggg accagaccgg acttaacaga tcaaccttta     5460

ccagatgcag atcacacttg gtacactgat ggtagttcac tccttcaaga gggtcaacgt     5520

aaagctggcg cagcagttac cactgaaacg gaagtaattt gggcaaaagc attacctgct     5580

ggtacttcag cccaaagagc tgagttgatt gccttgactc aagctcttaa aatggctgaa     5640

ggcaagaagc tgaatgtcta tactgactca agatacgctt ttgctactgc tcatattcac     5700

ggtgaaatct acagaagaag aggatggctt acgagtgaag gaaaagaaat taagaataag     5760

gatgagatat tagcacttct caaagcattg tttctgccaa agagactttc aattattcac     5820

tgtccaggac atcaaaaggg ccactccgcc gaagctaggg gtaatagaat ggcagatcag     5880

gcagcgagga aggctgccat cacagagact cctgatacat ctaccttatt aatagaaaac     5940

tcgtcgccaa attcacggtt aataaacggt agttcaggag gtagcaagag gactgctgat     6000

gggtctgaat tcgagccaaa gaagaagaga aaggttggct ccggttaa                  6048


<210>  157
<211>  2015
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic C-terminally fused REDRAW Editor

<400>  157

Met Ala Thr Ser Arg Lys Arg Pro Ser Asp Leu Val His Val Phe Ser 
1               5                   10                  15      


Pro Pro Arg Lys Lys Ala Gly Ser Ala Thr Ser Arg Lys Arg Pro Ser 
            20                  25                  30          


Asp Leu Val His Val Phe Ser Pro Pro Arg Lys Lys Ala Gly Ser Ser 
        35                  40                  45              


Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr Leu Arg 
    50                  55                  60                  


Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp Asn Lys 
65                  70                  75                  80  


Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys Gly Val 
                85                  90                  95      


Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp Val Leu 
            100                 105                 110         


His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu Phe Arg 
        115                 120                 125             


Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn Leu Glu 
    130                 135                 140                 


Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn Glu Gly 
145                 150                 155                 160 


Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu Pro Glu 
                165                 170                 175     


Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe Asn Gly 
            180                 185                 190         


Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn Met Phe 
        195                 200                 205             


Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile Asn Glu 
    210                 215                 220                 


Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys Val Asp 
225                 230                 235                 240 


Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys Ile Leu 
                245                 250                 255     


Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe Phe Asn 
            260                 265                 270         


Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile Ile Gly 
        275                 280                 285             


Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn Glu Tyr 
    290                 295                 300                 


Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys Phe Lys 
305                 310                 315                 320 


Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser Phe Tyr 
                325                 330                 335     


Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe Arg Asn 
            340                 345                 350         


Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys Leu Glu 
        355                 360                 365             


Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile Phe Val 
    370                 375                 380                 


Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe Gly Glu 
385                 390                 395                 400 


Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp Ile His 
                405                 410                 415     


Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp Arg Arg 
            420                 425                 430         


Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu Gln Glu 
        435                 440                 445             


Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu Ile Ile 
    450                 455                 460                 


Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser Glu Lys 
465                 470                 475                 480 


Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys Asn Asp 
                485                 490                 495     


Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys Ser Phe 
            500                 505                 510         


Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr Asn Arg 
        515                 520                 525             


Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile Leu Leu 
    530                 535                 540                 


Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr Gln Lys 
545                 550                 555                 560 


Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro Gln Phe 
                565                 570                 575     


Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala Thr Ile 
            580                 585                 590         


Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys Lys Tyr 
        595                 600                 605             


Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly Asn Tyr 
    610                 615                 620                 


Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met Leu Pro 
625                 630                 635                 640 


Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro Ser Glu 
                645                 650                 655     


Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly Asp Met 
            660                 665                 670         


Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys Asp Ser 
        675                 680                 685             


Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn Phe Ser 
    690                 695                 700                 


Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu Val Glu 
705                 710                 715                 720 


Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys Glu Val 
                725                 730                 735     


Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile Tyr Asn 
            740                 745                 750         


Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His Thr Met 
        755                 760                 765             


Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile Arg Leu 
    770                 775                 780                 


Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys Lys Glu 
785                 790                 795                 800 


Glu Leu Val Val Ala Pro Ala Asn Ser Pro Ile Ala Asn Lys Asn Pro 
                805                 810                 815     


Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr Lys Asp 
            820                 825                 830         


Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile Ala Ile 
        835                 840                 845             


Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val Arg Val 
    850                 855                 860                 


Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp Arg Gly 
865                 870                 875                 880 


Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly Asn Ile 
                885                 890                 895     


Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn Gly Ile 
            900                 905                 910         


Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu Lys Glu 
        915                 920                 925             


Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile Lys Glu 
    930                 935                 940                 


Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys Glu Leu 
945                 950                 955                 960 


Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn Ser Gly 
                965                 970                 975     


Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln Lys Phe 
            980                 985                 990         


Glu Lys Met Leu Ile Asp Lys Leu  Asn Tyr Met Val Asp  Lys Lys Ser 
        995                 1000                 1005             


Asn Pro  Cys Ala Thr Gly Gly  Ala Leu Lys Gly Tyr  Gln Ile Thr 
    1010                 1015                 1020             


Asn Lys  Phe Glu Ser Phe Lys  Ser Met Ser Thr Gln  Asn Gly Phe 
    1025                 1030                 1035             


Ile Phe  Tyr Ile Pro Ala Trp  Leu Thr Ser Lys Ile  Asp Pro Ser 
    1040                 1045                 1050             


Thr Gly  Phe Val Asn Leu Leu  Lys Thr Lys Tyr Thr  Ser Ile Ala 
    1055                 1060                 1065             


Asp Ser  Lys Lys Phe Ile Ser  Ser Phe Asp Arg Ile  Met Tyr Val 
    1070                 1075                 1080             


Pro Glu  Glu Asp Leu Phe Glu  Phe Ala Leu Asp Tyr  Lys Asn Phe 
    1085                 1090                 1095             


Ser Arg  Thr Asp Ala Asp Tyr  Ile Lys Lys Trp Lys  Leu Tyr Ser 
    1100                 1105                 1110             


Tyr Gly  Asn Arg Ile Arg Ile  Phe Arg Asn Pro Lys  Lys Asn Asn 
    1115                 1120                 1125             


Val Phe  Asp Trp Glu Glu Val  Cys Leu Thr Ser Ala  Tyr Lys Glu 
    1130                 1135                 1140             


Leu Phe  Asn Lys Tyr Gly Ile  Asn Tyr Gln Gln Gly  Asp Ile Arg 
    1145                 1150                 1155             


Ala Leu  Leu Cys Glu Gln Ser  Asp Lys Ala Phe Tyr  Ser Ser Phe 
    1160                 1165                 1170             


Met Ala  Leu Met Ser Leu Met  Leu Gln Met Arg Asn  Ser Ile Thr 
    1175                 1180                 1185             


Gly Arg  Thr Asp Val Asp Phe  Leu Ile Ser Pro Val  Lys Asn Ser 
    1190                 1195                 1200             


Asp Gly  Ile Phe Tyr Asp Ser  Arg Asn Tyr Glu Ala  Gln Glu Asn 
    1205                 1210                 1215             


Ala Ile  Leu Pro Lys Asn Ala  Asp Ala Asn Gly Ala  Tyr Asn Ile 
    1220                 1225                 1230             


Ala Arg  Lys Val Leu Trp Ala  Ile Gly Gln Phe Lys  Lys Ala Glu 
    1235                 1240                 1245             


Asp Glu  Lys Leu Asp Lys Val  Lys Ile Ala Ile Ser  Asn Lys Glu 
    1250                 1255                 1260             


Trp Leu  Glu Tyr Ala Gln Thr  Ser Val Lys His Ser  Gly Gly Ser 
    1265                 1270                 1275             


Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser 
    1280                 1285                 1290             


Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser Gly Gly  Ser Thr Leu 
    1295                 1300                 1305             


Asn Ile  Glu Asp Glu His Arg  Leu His Glu Thr Ser  Lys Glu Pro 
    1310                 1315                 1320             


Asp Val  Ser Leu Gly Ser Thr  Trp Leu Ser Asp Phe  Pro Gln Ala 
    1325                 1330                 1335             


Trp Ala  Glu Thr Gly Gly Met  Gly Leu Ala Val Arg  Gln Ala Pro 
    1340                 1345                 1350             


Leu Ile  Ile Pro Leu Lys Ala  Thr Ser Thr Pro Val  Ser Ile Lys 
    1355                 1360                 1365             


Gln Tyr  Pro Met Ser Gln Glu  Ala Arg Leu Gly Ile  Lys Pro His 
    1370                 1375                 1380             


Ile Gln  Arg Leu Leu Asp Gln  Gly Ile Leu Val Pro  Cys Gln Ser 
    1385                 1390                 1395             


Pro Trp  Asn Thr Pro Leu Leu  Pro Val Lys Lys Pro  Gly Thr Asn 
    1400                 1405                 1410             


Asp Tyr  Arg Pro Val Gln Asp  Leu Arg Glu Val Asn  Lys Arg Val 
    1415                 1420                 1425             


Glu Asp  Ile His Pro Thr Val  Pro Asn Pro Tyr Asn  Leu Leu Ser 
    1430                 1435                 1440             


Gly Leu  Pro Pro Ser His Gln  Trp Tyr Thr Val Leu  Asp Leu Lys 
    1445                 1450                 1455             


Asp Ala  Phe Phe Cys Leu Arg  Leu His Pro Thr Ser  Gln Pro Leu 
    1460                 1465                 1470             


Phe Ala  Phe Glu Trp Arg Asp  Pro Glu Met Gly Ile  Ser Gly Gln 
    1475                 1480                 1485             


Leu Thr  Trp Thr Arg Leu Pro  Gln Gly Phe Lys Asn  Ser Pro Thr 
    1490                 1495                 1500             


Leu Phe  Asn Glu Ala Leu His  Arg Asp Leu Ala Asp  Phe Arg Ile 
    1505                 1510                 1515             


Gln His  Pro Asp Leu Ile Leu  Leu Gln Tyr Val Asp  Asp Leu Leu 
    1520                 1525                 1530             


Leu Ala  Ala Thr Ser Glu Leu  Asp Cys Gln Gln Gly  Thr Arg Ala 
    1535                 1540                 1545             


Leu Leu  Gln Thr Leu Gly Asn  Leu Gly Tyr Arg Ala  Ser Ala Lys 
    1550                 1555                 1560             


Lys Ala  Gln Ile Cys Gln Lys  Gln Val Lys Tyr Leu  Gly Tyr Leu 
    1565                 1570                 1575             


Leu Lys  Glu Gly Gln Arg Trp  Leu Thr Glu Ala Arg  Lys Glu Thr 
    1580                 1585                 1590             


Val Met  Gly Gln Pro Thr Pro  Lys Thr Pro Arg Gln  Leu Arg Glu 
    1595                 1600                 1605             


Phe Leu  Gly Lys Ala Gly Phe  Cys Arg Leu Phe Ile  Pro Gly Phe 
    1610                 1615                 1620             


Ala Glu  Met Ala Ala Pro Leu  Tyr Pro Leu Thr Lys  Pro Gly Thr 
    1625                 1630                 1635             


Leu Phe  Asn Trp Gly Pro Asp  Gln Gln Lys Ala Tyr  Gln Glu Ile 
    1640                 1645                 1650             


Lys Gln  Ala Leu Leu Thr Ala  Pro Ala Leu Gly Leu  Pro Asp Leu 
    1655                 1660                 1665             


Thr Lys  Pro Phe Glu Leu Phe  Val Asp Glu Lys Gln  Gly Tyr Ala 
    1670                 1675                 1680             


Lys Gly  Val Leu Thr Gln Lys  Leu Gly Pro Trp Arg  Arg Pro Val 
    1685                 1690                 1695             


Ala Tyr  Leu Ser Lys Lys Leu  Asp Pro Val Ala Ala  Gly Trp Pro 
    1700                 1705                 1710             


Pro Cys  Leu Arg Met Val Ala  Ala Ile Ala Val Leu  Thr Lys Asp 
    1715                 1720                 1725             


Ala Gly  Lys Leu Thr Met Gly  Gln Pro Leu Val Ile  Leu Ala Pro 
    1730                 1735                 1740             


His Ala  Val Glu Ala Leu Val  Lys Gln Pro Pro Asp  Arg Trp Leu 
    1745                 1750                 1755             


Ser Asn  Ala Arg Met Thr His  Tyr Gln Ala Leu Leu  Leu Asp Thr 
    1760                 1765                 1770             


Asp Arg  Val Gln Phe Gly Pro  Val Val Ala Leu Asn  Pro Ala Thr 
    1775                 1780                 1785             


Leu Leu  Pro Leu Pro Glu Glu  Gly Leu Gln His Asn  Cys Leu Asp 
    1790                 1795                 1800             


Ile Leu  Ala Glu Ala His Gly  Thr Arg Pro Asp Leu  Thr Asp Gln 
    1805                 1810                 1815             


Pro Leu  Pro Asp Ala Asp His  Thr Trp Tyr Thr Asp  Gly Ser Ser 
    1820                 1825                 1830             


Leu Leu  Gln Glu Gly Gln Arg  Lys Ala Gly Ala Ala  Val Thr Thr 
    1835                 1840                 1845             


Glu Thr  Glu Val Ile Trp Ala  Lys Ala Leu Pro Ala  Gly Thr Ser 
    1850                 1855                 1860             


Ala Gln  Arg Ala Glu Leu Ile  Ala Leu Thr Gln Ala  Leu Lys Met 
    1865                 1870                 1875             


Ala Glu  Gly Lys Lys Leu Asn  Val Tyr Thr Asp Ser  Arg Tyr Ala 
    1880                 1885                 1890             


Phe Ala  Thr Ala His Ile His  Gly Glu Ile Tyr Arg  Arg Arg Gly 
    1895                 1900                 1905             


Trp Leu  Thr Ser Glu Gly Lys  Glu Ile Lys Asn Lys  Asp Glu Ile 
    1910                 1915                 1920             


Leu Ala  Leu Leu Lys Ala Leu  Phe Leu Pro Lys Arg  Leu Ser Ile 
    1925                 1930                 1935             


Ile His  Cys Pro Gly His Gln  Lys Gly His Ser Ala  Glu Ala Arg 
    1940                 1945                 1950             


Gly Asn  Arg Met Ala Asp Gln  Ala Ala Arg Lys Ala  Ala Ile Thr 
    1955                 1960                 1965             


Glu Thr  Pro Asp Thr Ser Thr  Leu Leu Ile Glu Asn  Ser Ser Pro 
    1970                 1975                 1980             


Asn Ser  Arg Leu Ile Asn Gly  Ser Ser Gly Gly Ser  Lys Arg Thr 
    1985                 1990                 1995             


Ala Asp  Gly Ser Glu Phe Glu  Pro Lys Lys Lys Arg  Lys Val Gly 
    2000                 2005                 2010             


Ser Gly  
    2015 


<210>  158
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  158
cgcggttcta tctagttacg cgttaaacca actagaa                                37


<210>  159
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  159
gcatacgatg gaagaggtaa ctt                                               23


<210>  160
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  160
gcatacgatt aaagaggtaa ctt                                               23


<210>  161
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  161
caaatagtcc tctttcaaca ata                                               23


<210>  162
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  162
cgttgtaaag aataaggaaa tgattccgga agctttggaa gtactgaa                    48


<210>  163
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  163
ataatgtcag atcctgtaga gaccacatca tccacggttc tatactgt                    48


<210>  164
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  164
tgaagtcgag gactttggca tacgatggaa gaggtaactt                             40


<210>  165
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  165
ccattcgtct tgaagtcgag gactttggca tacgatggaa gaggtaactt                  50


<210>  166
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  166
tgttggaaga gatttgggtt ttccattcgt cttgaagtcg aggactttgg catacgatgg       60

aagaggtaac tt                                                           72


<210>  167
<211>  47
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  167
ctaccttagc atcccttccc tttgcaaata gtcctctctc aacaata                     47


<210>  168
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  168
ttcaccctct accttagcat cccttccctt tgcaaatagt cctctctcaa caata            55


<210>  169
<211>  63
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  169
ctgtaacgtt caccctctac cttagcatcc cttccctttg caaatagtcc tctctcaaca       60

ata                                                                     63


<210>  170
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic LbCas12a crRNA scaffold

<400>  170
taatttctac taagtgtaga t                                                 21


<210>  171
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  171
cctcactcct gctcggtgaa ttt                                               23


<210>  172
<211>  683
<212>  PRT
<213>  Moloney Murine Leukemia Virus

<400>  172

Thr Leu Asn Ile Glu Asp Glu His Arg Leu His Glu Thr Ser Lys Glu 
1               5                   10                  15      


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
            20                  25                  30          


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
        35                  40                  45              


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
    50                  55                  60                  


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
65                  70                  75                  80  


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
                85                  90                  95      


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
            100                 105                 110         


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
        115                 120                 125             


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
    130                 135                 140                 


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
145                 150                 155                 160 


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
                165                 170                 175     


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
            180                 185                 190         


Lys Asn Ser Pro Thr Leu Phe Asp Glu Ala Leu His Arg Asp Leu Ala 
        195                 200                 205             


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
    210                 215                 220                 


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
225                 230                 235                 240 


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
                245                 250                 255     


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
            260                 265                 270         


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
        275                 280                 285             


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
    290                 295                 300                 


Gly Thr Ala Gly Phe Cys Arg Leu Trp Ile Pro Gly Phe Ala Glu Met 
305                 310                 315                 320 


Ala Ala Pro Leu Tyr Pro Leu Thr Lys Thr Gly Thr Leu Phe Asn Trp 
                325                 330                 335     


Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu 
            340                 345                 350         


Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu 
        355                 360                 365             


Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys 
    370                 375                 380                 


Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp 
385                 390                 395                 400 


Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile 
                405                 410                 415     


Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu 
            420                 425                 430         


Val Ile Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro 
        435                 440                 445             


Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu 
    450                 455                 460                 


Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro 
465                 470                 475                 480 


Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu 
                485                 490                 495     


Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln 
            500                 505                 510         


Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu 
        515                 520                 525             


Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr 
    530                 535                 540                 


Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg 
545                 550                 555                 560 


Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys 
                565                 570                 575     


Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His 
            580                 585                 590         


Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Leu Leu Thr Ser Glu Gly 
        595                 600                 605             


Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu 
    610                 615                 620                 


Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys 
625                 630                 635                 640 


Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala 
                645                 650                 655     


Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile 
            660                 665                 670         


Glu Asn Ser Ser Pro Asn Ser Arg Leu Ile Asn 
        675                 680             


<210>  173
<211>  122
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  173
acagcaggcc tttggtcagg ttggctgctg ggctggccct ggggccgtaa ccctcactcc       60

tgctcggtga atttggctca gcaggcacct gcctcagctg ctcacttgag cctctgggtc      120

ta                                                                     122


<210>  174
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  174
ggctgctggg ctggccctgg ggccgtaacc ctcactcctg ctcggtgaat ttggctcagc       60

aggcacctgc ctcagctgct cacttgagcc tctgggtcta                            100


<210>  175
<211>  92
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  175
ggctggccct ggggccgtaa ccctcactcc tgctcggtga atttggctca gcaggcacct       60

gcctcagctg ctcacttgag cctctgggtc ta                                     92


<210>  176
<211>  84
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  176
ctggggccgt aaccctcact cctgctcggt gaatttggct cagcaggcac ctgcctcagc       60

tgctcacttg agcctctggg tcta                                              84


<210>  177
<211>  122
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  177
acagcaggcc tttggtcagg ttggctgctg ggctggccct ggggccgttt ccctcactcc       60

tggacggtga atttggctca gcaggcacct gcctcagctg ctcacttgag cctctgggtc      120

ta                                                                     122


<210>  178
<211>  122
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  178
acagcaggcc tttggtcagg ttggctgctg ggctggccct ggggccgttt ccctcactcc       60

tgctgcgtga atttggctca gcaggcacct gcctcagctg ctcacttgag cctctgggtc      120

ta                                                                     122


<210>  179
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  179
aatagcattg cagagaggcg tatcatttcg cggatgttgg aatcagtacg cagagagtcg       60

ccgtctccaa ggtgaaagcg gaagtagggc cttcgcgcac                            100


<210>  180
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  180
aatagcattg cagagaggcg tatcatttcg cggatgttcc tttcagtacg cagagagtcg       60

ccgtctccaa ggtgaaagcg gaagtagggc cttcgcgcac                            100


<210>  181
<211>  122
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  181
acagcaggcc tttggtcagg ttggctgctg ggctggccct ggggccgtaa ccctcactcc       60

tgctcggtga atttggctca gcaggcacct gcctcagctg ctcacttgag cctctgggtc      120

ta                                                                     122


<210>  182
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  182
ggctgctggg ctggccctgg ggccgtaacc ctcactcctg ctcggtgaat ttggctcagc       60

aggcacctgc ctcagctgct cacttgagcc tctgggtcta                            100


<210>  183
<211>  92
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  183
ggctggccct ggggccgtaa ccctcactcc tgctcggtga atttggctca gcaggcacct       60

gcctcagctg ctcacttgag cctctgggtc ta                                     92


<210>  184
<211>  84
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  184
ctggggccgt aaccctcact cctgctcggt gaatttggct cagcaggcac ctgcctcagc       60

tgctcacttg agcctctggg tcta                                              84


<210>  185
<211>  122
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  185
gcactctgcc acttattggg tcagctgtta acatcagtac gttaatgtaa cctgatggtc       60

catgtctgtt actcgcctgt caagtggcgt gacaccgggc gtgttcccca gagtgacttt      120

tc                                                                     122


<210>  186
<211>  100
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  186
agctgttaac atcagtacgt taatgtaacc tgatggtcca tgtctgttac tcgcctgtca       60

agtggcgtga caccgggcgt gttccccaga gtgacttttc                            100


<210>  187
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  187
tttggctcac tcctgctcgg tgaattt                                           27


<210>  188
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  188
tttcgcgctt gttccaatca gtacgca                                           27


<210>  189
<211>  20
<212>  DNA
<213>  Acidaminococcus sp.

<400>  189
taatttctac tcttgtagat                                                   20


<210>  190
<211>  19
<212>  DNA
<213>  Bacteriophage lambda

<400>  190
gggccctgaa gaagggccc                                                    19


<210>  191
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  191
ttgacgcggt tctatctagt tacgcgttaa accaacuaga aa                          42


<210>  192
<211>  63
<212>  DNA
<213>  Moloney murine leukemia virus

<400>  192
ggaggtcagg gtcaggagcc cccccctgaa cccaggataa ccctcaaagt cggggggcaa       60

ccc                                                                     63


<210>  193
<211>  55
<212>  DNA
<213>  Moloney murine leukemia virus

<400>  193
gggtcaggag cccccccctg aacccaggat aaccctcaaa gtcggggggc aaccc            55


<210>  194
<211>  34
<212>  DNA
<213>  Bacteriophage MS2

<400>  194
ggccaacatg aggatcaccc atgtctgcag ggcc                                   34


<210>  195
<211>  29
<212>  DNA
<213>  Pseudomonas phage PP7

<400>  195
ccggagcaga cgatatggcg tcgctccgg                                         29


<210>  196
<211>  26
<212>  DNA
<213>  Homo sapiens

<400>  196
ccaaaggctc ttctcagagc caccca                                            26


<210>  197
<211>  31
<212>  DNA
<213>  Human immunodeficiency virus

<400>  197
ggccagatct gagcctggga gctctctggc c                                      31


<210>  198
<211>  36
<212>  DNA
<213>  Tetrahymena thermophila

<400>  198
atataacctt caccattagg ttcaaataat ggtaat                                 36


<210>  199
<211>  269
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  199

Asp Met Asp Ser Ile Gly Glu Ser Glu Val Arg Ala Leu Tyr Lys Ala 
1               5                   10                  15      


Ile Leu Lys Phe Gly Asn Leu Lys Glu Ile Leu Asp Glu Leu Ile Ala 
            20                  25                  30          


Asp Gly Thr Leu Pro Val Lys Ser Phe Glu Lys Tyr Gly Glu Thr Tyr 
        35                  40                  45              


Asp Glu Met Met Glu Ala Ala Lys Asp Cys Val His Glu Glu Glu Lys 
    50                  55                  60                  


Asn Arg Lys Glu Ile Leu Glu Lys Leu Glu Lys His Ala Thr Ala Tyr 
65                  70                  75                  80  


Arg Ala Lys Leu Lys Ser Gly Glu Ile Lys Ala Glu Asn Gln Pro Lys 
                85                  90                  95      


Asp Asn Pro Leu Thr Arg Leu Ser Leu Lys Lys Arg Glu Lys Lys Ala 
            100                 105                 110         


Val Leu Phe Asn Phe Lys Gly Val Lys Ser Leu Asn Ala Glu Ser Leu 
        115                 120                 125             


Leu Ser Arg Val Glu Asp Leu Lys Tyr Leu Lys Asn Leu Ile Asn Ser 
    130                 135                 140                 


Asn Tyr Lys Asp Asp Pro Leu Lys Phe Ser Leu Gly Asn Asn Thr Pro 
145                 150                 155                 160 


Lys Pro Val Gln Asn Trp Ser Ser Asn Trp Thr Lys Glu Glu Asp Glu 
                165                 170                 175     


Lys Leu Leu Ile Gly Val Phe Lys Tyr Gly Tyr Gly Ser Trp Thr Gln 
            180                 185                 190         


Ile Arg Asp Asp Pro Phe Leu Gly Ile Thr Asp Lys Ile Phe Leu Asn 
        195                 200                 205             


Glu Val His Asn Pro Val Ala Lys Lys Ser Ala Ser Ser Ser Asp Thr 
    210                 215                 220                 


Thr Pro Thr Pro Ser Lys Lys Gly Lys Gly Ile Thr Gly Ser Ser Lys 
225                 230                 235                 240 


Lys Val Pro Gly Ala Ile His Leu Gly Arg Arg Val Asp Tyr Leu Leu 
                245                 250                 255     


Ser Phe Leu Arg Gly Gly Leu Asn Thr Lys Ser Pro Ser 
            260                 265                 


<210>  200
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  200

Ser Thr Asp His Pro Lys Tyr Ser Asp Met Ile Val Ala Ala Ile Gln 
1               5                   10                  15      


Ala Glu Lys Asn Arg Ala Gly Ser Ser Arg Gln Ser Ile Gln Lys Tyr 
            20                  25                  30          


Ile Lys Ser His Tyr Lys Val Gly Glu Asn Ala Asp Ser Gln Ile Lys 
        35                  40                  45              


Leu Ser Ile Lys Arg Leu Val Thr Thr Gly Val Leu Lys Gln Thr Lys 
    50                  55                  60                  


Gly Val Gly Ala Ser Gly Ser Phe Arg Leu Ala Lys Ser Asp Glu Pro 
65                  70                  75                  80  


<210>  201
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  201

Gly Lys Gly Asp Pro Lys Lys Pro Arg Gly Lys Met Ser Ser Tyr Ala 
1               5                   10                  15      


Phe Phe Val Gln Thr Cys Arg Glu Glu His Lys Lys Lys His Pro Asp 
            20                  25                  30          


Ala Ser Val Asn Phe Ser Glu Phe Ser Lys Lys Cys Ser Glu Arg Trp 
        35                  40                  45              


Lys Thr Met Ser Ala Lys Glu Lys Gly Lys Phe Glu Asp Met Ala Lys 
    50                  55                  60                  


Ala Asp Lys Ala Arg Tyr Glu Arg Glu Met Lys Thr Tyr Ile Pro Pro 
65                  70                  75                  80  


Lys Gly Glu 
            


<210>  202
<211>  100
<212>  PRT
<213>  Papio anubis

<400>  202

Met Pro Lys Arg Lys Val Ser Ser Ala Glu Gly Ala Ala Lys Glu Glu 
1               5                   10                  15      


Pro Lys Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro Pro Ala Lys Val 
            20                  25                  30          


Glu Ala Lys Pro Lys Lys Ala Ala Ala Lys Asp Lys Ser Ser Asp Lys 
        35                  40                  45              


Lys Val Gln Thr Lys Gly Lys Arg Gly Ala Lys Gly Lys Gln Ala Glu 
    50                  55                  60                  


Val Ala Asn Gln Glu Thr Lys Glu Asp Leu Pro Ala Glu Asn Gly Glu 
65                  70                  75                  80  


Thr Lys Thr Glu Glu Ser Pro Ala Ser Asp Glu Ala Gly Glu Lys Glu 
                85                  90                  95      


Ala Lys Ser Asp 
            100 


<210>  203
<211>  21
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  203
uaagucucca uagaauggag g                                                 21


<210>  204
<211>  102
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  204
gaacgtcacc tggaaccgac cttgctggcc gtacatttat acggctccgc agtggatggc       60

ggctgaaagc cacacagtga tattgatttg ctggttacgg tg                         102


<210>  205
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  205

Glu Arg His Leu Glu Pro Thr Leu Leu Ala Val His Leu Tyr Gly Ser 
1               5                   10                  15      


Ala Val Asp Gly Gly 
            20      


<210>  206
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  206

Lys Pro His Ser Asp Ile Asp Leu Leu Val Thr Val 
1               5                   10          


<210>  207
<211>  102
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  207
gaacgtcacc tggaaccgac cttgctggcc gtacatttat acggctccgc agtggatggc       60

ggcctgaagc cacacagtga tattgatttg ctggttacgg tg                         102


<210>  208
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  208

Glu Arg His Leu Glu Pro Thr Leu Leu Ala Val His Leu Tyr Gly Ser 
1               5                   10                  15      


Ala Val Asp Gly Gly Leu Lys Pro His Ser Asp Ile Asp Leu Leu Val 
            20                  25                  30          


Thr Val 
        


<210>  209
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  209
catgcccgca aaaacgtggc gtatgtactc gtgtatatac taccactcct aaaaaaccga       60

actccgcgct gcgtaaagta tgccgtgttc gtctgact                               98


<210>  210
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  210

Ala Cys Pro Gln Lys Arg Gly Val Cys Thr Arg Val Tyr Thr Thr Thr 
1               5                   10                  15      


Pro Lys Lys Pro Asn Ser Ala Leu Arg Lys Val Cys Arg Val Arg Leu 
            20                  25                  30          


Thr 
    


<210>  211
<211>  98
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  211
catgcccgca aaaacgtggc gtatgtactc gtgtatatac taccactcct cgtaaaccga       60

actccgcgct gcgtaaagta tgccgtgttc gtctgact                               98


<210>  212
<211>  120
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  212
atttatacgg ctccgcagtg gatggcggcc tgaagccaca cagtgatatt gatttgctgg       60

ttacggtgac cgtacgcctt tgagaaacaa cgcgccgcgc tttgatcaac gaccttttgg      120


<210>  213
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  213

His Leu Tyr Gly Ser Ala Val Asp Gly Gly Leu Lys Pro His Ser Asp 
1               5                   10                  15      


Ile Asp Leu Leu Val Thr Val Thr Val Arg Leu 
            20                  25          


<210>  214
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide

<400>  214

Glu Thr Thr Arg Arg Ala Leu Ile Asn Asp Leu Leu 
1               5                   10          


<210>  215
<211>  120
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide

<400>  215
atttatacgg ctccgcagtg gatggcggcc tgaagccaca cagtgatatt gatttgctgg       60

ttacggtgac cgtacgcctt gatgaaacaa cgcgccgcgc tttgatcaac gaccttttgg      120


