                         SEQUENCE LISTING

<110>  Fate Therapeutics, Inc.
       Valamehr, Bahram
       Peralta, Eigen
       Chang, Chia-Wei
 
<120>  Engineered iPSC and Persistent Immune Effector Cells

<130>  184143-631601

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  635
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
            20                  25                  30          


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
        35                  40                  45              


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
    50                  55                  60                  


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
65                  70                  75                  80  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
                85                  90                  95      


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
            100                 105                 110         


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
        115                 120                 125             


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
145                 150                 155                 160 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Ser Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Ser Leu Gln Glu Ser Gly Tyr Ala Gln Asn Gly Asp Leu Glu Asp 
        195                 200                 205             


Ala Glu Leu Asp Asp Tyr Ser Phe Ser Cys Tyr Ser Gln Leu Glu Val 
    210                 215                 220                 


Asn Gly Ser Gln His Ser Leu Thr Cys Ala Phe Glu Asp Pro Asp Val 
225                 230                 235                 240 


Asn Ile Thr Asn Leu Glu Phe Glu Ile Cys Gly Ala Leu Val Glu Val 
                245                 250                 255     


Lys Cys Leu Asn Phe Arg Lys Leu Gln Glu Ile Tyr Phe Ile Glu Thr 
            260                 265                 270         


Lys Lys Phe Leu Leu Ile Gly Lys Ser Asn Ile Cys Val Lys Val Gly 
        275                 280                 285             


Glu Lys Ser Leu Thr Cys Lys Lys Ile Asp Leu Thr Thr Ile Val Lys 
    290                 295                 300                 


Pro Glu Ala Pro Phe Asp Leu Ser Val Val Tyr Arg Glu Gly Ala Asn 
305                 310                 315                 320 


Asp Phe Val Val Thr Phe Asn Thr Ser His Leu Gln Lys Lys Tyr Val 
                325                 330                 335     


Lys Val Leu Met His Asp Val Ala Tyr Arg Gln Glu Lys Asp Glu Asn 
            340                 345                 350         


Lys Trp Thr His Val Asn Leu Ser Ser Thr Lys Leu Thr Leu Leu Gln 
        355                 360                 365             


Arg Lys Leu Gln Pro Ala Ala Met Tyr Glu Ile Lys Val Arg Ser Ile 
    370                 375                 380                 


Pro Asp His Tyr Phe Lys Gly Phe Trp Ser Glu Trp Ser Pro Ser Tyr 
385                 390                 395                 400 


Tyr Phe Arg Thr Pro Glu Ile Asn Asn Ser Ser Gly Glu Met Asp Pro 
                405                 410                 415     


Ile Leu Leu Thr Ile Ser Ile Leu Ser Phe Phe Ser Val Ala Leu Leu 
            420                 425                 430         


Val Ile Leu Ala Cys Val Leu Trp Lys Lys Arg Ile Lys Pro Ile Val 
        435                 440                 445             


Trp Pro Ser Leu Pro Asp His Lys Lys Thr Leu Glu His Leu Cys Lys 
    450                 455                 460                 


Lys Pro Arg Lys Asn Leu Asn Val Ser Phe Asn Pro Glu Ser Phe Leu 
465                 470                 475                 480 


Asp Cys Gln Ile His Arg Val Asp Asp Ile Gln Ala Arg Asp Glu Val 
                485                 490                 495     


Glu Gly Phe Leu Gln Asp Thr Phe Pro Gln Gln Leu Glu Glu Ser Glu 
            500                 505                 510         


Lys Gln Arg Leu Gly Gly Asp Val Gln Ser Pro Asn Cys Pro Ser Glu 
        515                 520                 525             


Asp Val Val Ile Thr Pro Glu Ser Phe Gly Arg Asp Ser Ser Leu Thr 
    530                 535                 540                 


Cys Leu Ala Gly Asn Val Ser Ala Cys Asp Ala Pro Ile Leu Ser Ser 
545                 550                 555                 560 


Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro His Val 
                565                 570                 575     


Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr Leu Pro 
            580                 585                 590         


Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro Val Ala 
        595                 600                 605             


Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu Glu Ala 
    610                 615                 620                 


Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
625                 630                 635 


<210>  2
<211>  153
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        35                  40                  45              


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    50                  55                  60                  


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                85                  90                  95      


Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe 
            100                 105                 110         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        115                 120                 125             


Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala 
    130                 135                 140                 


Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150             


<210>  3
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
            100                 105                 110         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        115                 120                 125             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    130                 135                 140                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
145                 150                 155                 160 


Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                165                 170                 175     


Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            180                 185                 190         


His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
        195                 200                 205             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 


<210>  4
<211>  263
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Ser Asn Leu Phe Val Ala Ser Trp Ile Ala Val Met Ile Ile Phe Arg 
1               5                   10                  15      


Ile Gly Met Ala Val Ala Ile Phe Cys Cys Phe Phe Phe Pro Ser Trp 
            20                  25                  30          


Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe 
        35                  40                  45              


Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His 
    50                  55                  60                  


Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met 
65                  70                  75                  80  


Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr 
                85                  90                  95      


Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg 
            100                 105                 110         


Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys 
        115                 120                 125             


Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu 
    130                 135                 140                 


Glu Asn Phe Asp Val Tyr Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
145                 150                 155                 160 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                165                 170                 175     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        195                 200                 205             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    210                 215                 220                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
225                 230                 235                 240 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                245                 250                 255     


Met Gln Ala Leu Pro Pro Arg 
            260             


<210>  5
<211>  308
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ser Asn Leu 
        35                  40                  45              


Phe Val Ala Ser Trp Ile Ala Val Met Ile Ile Phe Arg Ile Gly Met 
    50                  55                  60                  


Ala Val Ala Ile Phe Cys Cys Phe Phe Phe Pro Ser Trp Arg Arg Lys 
65                  70                  75                  80  


Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile 
                85                  90                  95      


Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu 
            100                 105                 110         


Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser 
        115                 120                 125             


Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser 
    130                 135                 140                 


Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser 
145                 150                 155                 160 


Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro 
                165                 170                 175     


Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe 
            180                 185                 190         


Asp Val Tyr Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        195                 200                 205             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    210                 215                 220                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
225                 230                 235                 240 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                245                 250                 255     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            260                 265                 270         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        275                 280                 285             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    290                 295                 300                 


Leu Pro Pro Arg 
305             


<210>  6
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  7
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr 
            20      


<210>  8
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Met Ala Leu Ile Val Leu Gly Gly Val Ala Gly Leu Leu Leu Phe Ile 
1               5                   10                  15      


Gly Leu Gly Ile Phe Phe 
            20          


<210>  9
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile 
    50                  55  


<210>  10
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Ser Arg Ile 
    50                  55  


<210>  11
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        35                  40                  45  


<210>  12
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Ala 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Ala Asn Lys 
        35                  40                  45  


<210>  13
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn 
        35                  40                  45  


<210>  14
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Ala 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Ala Arg Asn 
        35                  40                  45  


<210>  15
<211>  41
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  16
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr 
    


<210>  17
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp Gly Ser Ala Asp Asp Ala Lys Lys 
            100                 105                 110         


Asp Ala Ala Lys Lys Asp Asp Ala Lys Lys Asp Asp Ala Lys Lys Asp 
        115                 120                 125             


Gly Ser Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg Val Phe Val 
    130                 135                 140                 


Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val Gly Thr Leu 
145                 150                 155                 160 


Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile Leu Asp Pro 
                165                 170                 175     


Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys Asp Lys Glu 
            180                 185                 190         


Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys Val Glu Leu 
        195                 200                 205             


Asp Pro Ala Thr Val Ala 
    210                 


<210>  18
<211>  224
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Asp Gly Asn Glu Glu Met Gly Gly Ile Thr Gln Thr Pro Tyr Lys Val 
1               5                   10                  15      


Ser Ile Ser Gly Thr Thr Val Ile Leu Thr Cys Pro Gln Tyr Pro Gly 
            20                  25                  30          


Ser Glu Ile Leu Trp Gln His Asn Asp Lys Asn Ile Gly Gly Asp Glu 
        35                  40                  45              


Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp His Leu Ser Leu Lys Glu 
    50                  55                  60                  


Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr Val Cys Tyr Pro Arg Gly 
65                  70                  75                  80  


Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu Tyr Leu Arg Ala Arg Val 
                85                  90                  95      


Cys Glu Asn Cys Met Glu Met Asp Gly Ser Ala Asp Asp Ala Lys Lys 
            100                 105                 110         


Asp Ala Ala Lys Lys Asp Asp Ala Lys Lys Asp Asp Ala Lys Lys Asp 
        115                 120                 125             


Gly Ser Gln Ser Ile Lys Gly Asn His Leu Val Lys Val Tyr Asp Tyr 
    130                 135                 140                 


Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala Glu Ala Lys Asn 
145                 150                 155                 160 


Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe Leu Thr Glu Asp 
                165                 170                 175     


Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp Pro Arg Gly Met 
            180                 185                 190         


Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro Leu Gln Val Tyr 
        195                 200                 205             


Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala Ala Thr Ile Ser 
    210                 215                 220                 


<210>  19
<211>  340
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu 
    290                 295                 300                 


Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg 
305                 310                 315                 320 


Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp 
                325                 330                 335     


Pro Gln Asp Lys 
            340 


<210>  20
<211>  336
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Phe Phe Pro Pro Gly 
        275                 280                 285             


Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp 
    290                 295                 300                 


Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg 
305                 310                 315                 320 


Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                325                 330                 335     


<210>  21
<211>  335
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Phe Phe Pro Pro Gly Tyr 
        275                 280                 285             


Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr 
    290                 295                 300                 


Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp 
305                 310                 315                 320 


Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                325                 330                 335 


<210>  22
<211>  1032
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
cttggagaca acatgtggtt cttgacaact ctgctccttt gggttccagt tgatgggcaa       60

gtggacacca caaaggcagt gatcactttg cagcctccat gggtcagcgt gttccaagag      120

gaaaccgtaa ccttgcattg tgaggtgctc catctgcctg ggagcagctc tacacagtgg      180

tttctcaatg gcacagccac tcagacctcg acccccagct acagaatcac ctctgccagt      240

gtcaatgaca gtggtgaata caggtgccag agaggtctct cagggcgaag tgaccccata      300

cagctggaaa tccacagagg ctggctacta ctgcaggtct ccagcagagt cttcacggaa      360

ggagaacctc tggccttgag gtgtcatgcg tggaaggata agctggtgta caatgtgctt      420

tactatcgaa atggcaaagc ctttaagttt ttccactgga attctaacct caccattctg      480

aaaaccaaca taagtcacaa tggcacctac cattgctcag gcatgggaaa gcatcgctac      540

acatcagcag gaatatctgt cactgtgaaa gagctatttc cagctccagt gctgaatgca      600

tctgtgacat ccccactcct ggaggggaat ctggtcaccc tgagctgtga aacaaagttg      660

ctcttgcaga ggcctggttt gcagctttac ttctccttct acatgggcag caagaccctg      720

cgaggcagga acacatcctc tgaataccaa atactaactg ctagaagaga agactctggg      780

ttatactggt gcgaggctgc cacagaggat ggaaatgtcc ttaagcgcag ccctgagttg      840

gagcttcaag tgcttggcct ccagttacca actcctgtct ggtttcatta ccaagtctct      900

ttctgcttgg tgatggtact cctttttgca gtggacacag gactatattt ctctgtgaag      960

acaaacattc gaagctcaac aagagactgg aaggaccata aatttaaatg gagaaaggac     1020

cctcaagaca aa                                                         1032


<210>  23
<211>  1020
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
cttggagaca acatgtggtt cttgacaact ctgctccttt gggttccagt tgatgggcaa       60

gtggacacca caaaggcagt gatcactttg cagcctccat gggtcagcgt gttccaagag      120

gaaaccgtaa ccttgcattg tgaggtgctc catctgcctg ggagcagctc tacacagtgg      180

tttctcaatg gcacagccac tcagacctcg acccccagct acagaatcac ctctgccagt      240

gtcaatgaca gtggtgaata caggtgccag agaggtctct cagggcgaag tgaccccata      300

cagctggaaa tccacagagg ctggctacta ctgcaggtct ccagcagagt cttcacggaa      360

ggagaacctc tggccttgag gtgtcatgcg tggaaggata agctggtgta caatgtgctt      420

tactatcgaa atggcaaagc ctttaagttt ttccactgga attctaacct caccattctg      480

aaaaccaaca taagtcacaa tggcacctac cattgctcag gcatgggaaa gcatcgctac      540

acatcagcag gaatatctgt cactgtgaaa gagctatttc cagctccagt gctgaatgca      600

tctgtgacat ccccactcct ggaggggaat ctggtcaccc tgagctgtga aacaaagttg      660

ctcttgcaga ggcctggttt gcagctttac ttctccttct acatgggcag caagaccctg      720

cgaggcagga acacatcctc tgaataccaa atactaactg ctagaagaga agactctggg      780

ttatactggt gcgaggctgc cacagaggat ggaaatgtcc ttaagcgcag ccctgagttg      840

gagcttcaag tgcttggttt gttctttcca cctgggtacc aagtctcttt ctgcttggtg      900

atggtactcc tttttgcagt ggacacagga ctatatttct ctgtgaagac aaacattcga      960

agctcaacaa gagactggaa ggaccataaa tttaaatgga gaaaggaccc tcaagacaaa     1020


<210>  24
<211>  1005
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
atgtggttct tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca       60

aaggcagtga tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc      120

ttgcactgtg aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc      180

acagccactc agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt      240

ggtgaataca ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc      300

cacagaggct ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg      360

gccttgaggt gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat      420

ggcaaagcct ttaagttttt ccactggaac tctaacctca ccattctgaa aaccaacata      480

agtcacaatg gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga      540

atatctgtca ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc      600

ccactcctgg aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg      660

cctggtttgc agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac      720

acatcctctg aataccaaat actaactgct agaagagaag actctgggtt atactggtgc      780

gaggctgcca cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg      840

cttggcttct ttccacctgg gtaccaagtc tctttctgct tggtgatggt actccttttt      900

gcagtggaca caggactata tttctctgtg aagacaaaca ttcgaagctc aacaagagac      960

tggaaggacc ataaatttaa atggagaaag gaccctcaag acaaa                     1005


