                         SEQUENCE LISTING

<110>  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
 
<120>  ENGINEERED T CELL RECEPTORS TARGETING  EGFR ANTIGENS AND METHODS 
       OF USE

<130>  MDAC.P1244WO

<150>  63/110,116
<151>  2020-11-05

<160>  93    

<170>  PatentIn version 3.5

<210>  1
<211>  1854
<212>  DNA
<213>  Homo Sapiens

<400>  1
atggatacct ggctcgtatg ctgggcaatt tttagtctct tgaaagcagg actcacagaa       60

cctgaagtca cccagactcc cagccatcag gtcacacaga tgggacagga agtgatcttg      120

cgctgtgtcc ccatctctaa tcacttatac ttctattggt acagacaaat cttggggcag      180

aaagtcgagt ttctggtttc cttttataat aatgaaatct cagagaagtc tgaaatattc      240

gatgatcaat tctcagttga aaggcctgat ggatcaaatt tcactctgaa gatccggtcc      300

acaaagctgg aggactcagc catgtacttc tgtgccagca gtggtgccgg gggtaggtac      360

gagcagtact tcgggccggg caccaggctc acggtcacag aggacctgaa aaacgtgttc      420

ccacccgagg tcgctgtgtt tgagccatca gaagcagaga tctcccacac ccaaaaggcc      480

acactggtat gcctggccac aggcttctac cccgaccacg tggagctgag ctggtgggtg      540

aatgggaagg aggtgcacag tggggtcagc acagacccgc agcccctcaa ggagcagccc      600

gccctcaatg actccagata ctgcctgagc agccgcctga gggtctcggc caccttctgg      660

cagaaccccc gcaaccactt ccgctgtcaa gtccagttct acgggctctc ggagaatgac      720

gagtggaccc aggatagggc caaacccgtc acccagatcg tcagcgccga ggcctggggt      780

agagcagact gtggcttcac ctccgagtct taccagcaag gggtcctgtc tgccaccatc      840

ctctatgaga tcttgctagg gaaggccacc ttgtatgccg tgctggtcag tgccctcgtg      900

ctgatggcca tggtcaagag aaaggatttc agaggccgtg ccaagcgaag cggatctggc      960

gccacgaact tctctctgtt aaagcaagca ggagatgttg aagaaaaccc cgggcctatg     1020

tcactttcta gcctgctgaa ggtggtcaca gcttcactgt ggctaggacc tggcattgcc     1080

cagaagataa ctcaaaccca accaggaatg ttcgtgcagg aaaaggaggc tgtgactctg     1140

gactgcacat atgacaccag tgatccaagt tatggtctat tctggtacaa gcagcccagc     1200

agtggggaaa tgatttttct tatttatcag gggtcttatg accagcaaaa tgcaacagaa     1260

ggtcgctact cattgaattt ccagaaggca agaaaatccg ccaaccttgt catctccgct     1320

tcacaactgg gggactcagc aatgtacttc tgtgcaatga gaggtatatc taactttgga     1380

aatgagaaat taacctttgg gactggaaca agactcacca tcatacccaa tatccagaag     1440

cctgaccctg ccgtgtacca gctgagagac tctaaatcca gtgacaagtc tgtctgccta     1500

ttcaccgatt ttgattctca aacaaatgtg tcacaaagta aggattctga tgtgtatatc     1560

acagacaaaa ctgtgctaga catgaggtct atggacttca agagcaacag tgctgtggcc     1620

tggagcaaca aatctgactt tgcatgtgca aacgccttca acaacagcat tattccagca     1680

gacaccttct tccccagccc agaaagttcc tgtgatgtca agctggtcga gaaaagcttt     1740

gaaacagata cgaacctaaa ctttcaaaac ctgtcagtga ttgtgttccg aatcctcctc     1800

ctgaaagtgg ccgggtttaa tctgctcatg acgctgcggc tgtggtccag ctga           1854


<210>  2
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  2

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr 
            20                  25                  30          


Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His 
        35                  40                  45              


Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe 
    50                  55                  60                  


Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe 
65                  70                  75                  80  


Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu 
                85                  90                  95      


Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala 
            100                 105                 110         


Ser Ser Gly Ala Gly Gly Arg Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
    130                 135                 140                 


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
        195                 200                 205             


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
    210                 215                 220                 


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
225                 230                 235                 240 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
                245                 250                 255     


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
            260                 265                 270         


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
        275                 280                 285             


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
    290                 295                 300                 


Val Lys Arg Lys Asp Phe Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly 
305                 310                 315                 320 


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
                325                 330                 335     


Pro Gly Pro Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser 
            340                 345                 350         


Leu Trp Leu Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro 
        355                 360                 365             


Gly Met Phe Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr 
    370                 375                 380                 


Asp Thr Ser Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser 
385                 390                 395                 400 


Ser Gly Glu Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln 
                405                 410                 415     


Asn Ala Thr Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys 
            420                 425                 430         


Ser Ala Asn Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met 
        435                 440                 445             


Tyr Phe Cys Ala Met Arg Gly Ile Ser Asn Phe Gly Asn Glu Lys Leu 
    450                 455                 460                 


Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Lys 
465                 470                 475                 480 


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
                485                 490                 495     


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln 
            500                 505                 510         


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met 
        515                 520                 525             


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys 
    530                 535                 540                 


Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Ala 
545                 550                 555                 560 


Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val 
                565                 570                 575     


Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser 
            580                 585                 590         


Val Ile Val Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
        595                 600                 605             


Leu Met Thr Leu Arg Leu Trp Ser Ser 
    610                 615         


<210>  3
<211>  320
<212>  PRT
<213>  Homo Sapiens

<400>  3

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Gly 
                85                  90                  95      


Ala Gly Gly Arg Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
        115                 120                 125             


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
                165                 170                 175     


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
            180                 185                 190         


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
        195                 200                 205             


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
    210                 215                 220                 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
225                 230                 235                 240 


Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
                245                 250                 255     


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
            260                 265                 270         


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
        275                 280                 285             


Lys Asp Phe Arg Gly Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn 
    290                 295                 300                 


Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
305                 310                 315                 320 


<210>  4
<211>  109
<212>  PRT
<213>  Homo Sapiens

<400>  4

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Gly 
                85                  90                  95      


Ala Gly Gly Arg Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
            100                 105                 


<210>  5
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  5

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr 
            


<210>  6
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  6

Ser Asn His Leu Tyr Phe 
1               5       


<210>  7
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  7

Phe Tyr Asn Asn Glu 
1               5   


<210>  8
<211>  12
<212>  PRT
<213>  Homo Sapiens

<400>  8

Ala Ser Ser Gly Ala Gly Gly Arg Tyr Glu Gln Tyr 
1               5                   10          


<210>  9
<211>  258
<212>  PRT
<213>  Homo Sapiens

<400>  9

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Gly 
                85                  90                  95      


Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg 
            100                 105                 110         


Leu Thr Ile Ile Pro Asn Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
145                 150                 155                 160 


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
                165                 170                 175     


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
            180                 185                 190         


Ala Phe Asn Asn Ser Ile Ile Pro Ala Asp Thr Phe Phe Pro Ser Pro 
        195                 200                 205             


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
    210                 215                 220                 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Val Phe Arg Ile Leu 
225                 230                 235                 240 


Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp 
                245                 250                 255     


Ser Ser 
        


<210>  10
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  10

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Gly 
                85                  90                  95      


Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg 
            100                 105                 110         


Leu Thr Ile Ile Pro 
        115         


<210>  11
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  11

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile 
            20  


<210>  12
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  12

Thr Ser Asp Pro Ser Tyr Gly 
1               5           


<210>  13
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  13

Gln Gly Ser Tyr Asp Gln Gln Asn 
1               5               


<210>  14
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  14

Ala Met Arg Gly Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr 
1               5                   10                  


<210>  15
<211>  1865
<212>  DNA
<213>  Homo Sapiens

<400>  15
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tgagagttat atctaacttt      360

ggaaatgaga aattaacctt tgggactgga acaagactca ccatcatacc caatatccag      420

aagcctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa gtctgtctgc      480

ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc tgatgtgtat      540

atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa cagtgctgtg      600

gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag cattattcca      660

gcagacacct tcttccccag cccagaaagt tcctgtgatg tcaagctggt cgagaaaagc      720

tttgaaacag atacgaacct aaactttcaa aacctgtcag tgattgggtt ccgaatcctc      780

ctcctgaaag tggccgggtt ttatctgctc atgacgctgc ggctgtggtc cagcgtcgac      840

gtgccaagcg aagcggatct ggcgccacga acttctctct gttaaagcaa gcaggagatg      900

ttgaagaaaa ccccgggcct ctcgagatgg atacctggct cgtatgctgg gcaattttta      960

gtctcttgaa agcaggactc acagaacctg aagtcaccca gactcccagc catcaggtca     1020

cacagatggg acaggaagtg atcttgcgct gtgtccccat ctctaatcac ttatacttct     1080

attggtacag acaaatcttg gggcagaaag tcgagtttct ggtttccttt tataataatg     1140

aaatctcaga gaagtctgaa atattcgatg atcaattctc agttgaaagg cctgatggat     1200

caaatttcac tctgaagatc cggtccacaa agctggagga ctcagccatg tacttctgtg     1260

ccagcagtct cggcgggggc acctacgagc agtacttcgg gccgggcacc aggctcacgg     1320

tcacagagga cctgaaaaac gtgttcccac ccgaggtcgc tgtgtttgag ccatcagaag     1380

cagagatctc ccacacccaa aaggccacac tggtgtgcct ggccacaggc ttcttccctg     1440

accacgtgga gctgagctgg tgggtgaatg ggaaggaggt gcacagtggg gtcagcacag     1500

acccgcagcc cctcaaggag cagcccgccc tcaatgactc cagatactgc ctgagcagcc     1560

gcctgagggt ctcggccacc ttctggcaga acccccgcaa ccacttccgc tgtcaagtcc     1620

agttctacgg gctctcggag aatgacgagt ggacccagga tagggccaaa cctgtcaccc     1680

agatcgtcag cgccgaggcc tggggtagag cagactgtgg cttcacctcc gagtcttacc     1740

agcaaggggt cctgtctgcc accatcctct atgagatctt gctagggaag gccaccttgt     1800

atgccgtgct ggtcagtgcc ctcgtgctga tggccatggt caagagaaag gattccagag     1860

gctag                                                                 1865


<210>  16
<211>  621
<212>  PRT
<213>  Homo Sapiens

<400>  16

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Val Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly 
        115                 120                 125             


Thr Gly Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Lys Pro Asp Pro 
    130                 135                 140                 


Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys 
145                 150                 155                 160 


Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp 
                165                 170                 175     


Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met 
            180                 185                 190         


Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe 
        195                 200                 205             


Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Ala Asp Thr Phe 
    210                 215                 220                 


Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser 
225                 230                 235                 240 


Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly 
                245                 250                 255     


Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Tyr Leu Leu Met Thr 
            260                 265                 270         


Leu Arg Leu Trp Ser Ser Val Asp Arg Ala Lys Arg Ser Gly Ser Gly 
        275                 280                 285             


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
    290                 295                 300                 


Pro Gly Pro Leu Glu Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe 
305                 310                 315                 320 


Ser Leu Leu Lys Ala Gly Leu Thr Glu Pro Glu Val Thr Gln Thr Pro 
                325                 330                 335     


Ser His Gln Val Thr Gln Met Gly Gln Glu Val Ile Leu Arg Cys Val 
            340                 345                 350         


Pro Ile Ser Asn His Leu Tyr Phe Tyr Trp Tyr Arg Gln Ile Leu Gly 
        355                 360                 365             


Gln Lys Val Glu Phe Leu Val Ser Phe Tyr Asn Asn Glu Ile Ser Glu 
    370                 375                 380                 


Lys Ser Glu Ile Phe Asp Asp Gln Phe Ser Val Glu Arg Pro Asp Gly 
385                 390                 395                 400 


Ser Asn Phe Thr Leu Lys Ile Arg Ser Thr Lys Leu Glu Asp Ser Ala 
                405                 410                 415     


Met Tyr Phe Cys Ala Ser Ser Leu Gly Gly Gly Thr Tyr Glu Gln Tyr 
            420                 425                 430         


Phe Gly Pro Gly Thr Arg Leu Thr Val Thr Glu Asp Leu Lys Asn Val 
        435                 440                 445             


Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser 
    450                 455                 460                 


His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro 
465                 470                 475                 480 


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
                485                 490                 495     


Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn 
            500                 505                 510         


Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe 
        515                 520                 525             


Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly 
    530                 535                 540                 


Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr 
545                 550                 555                 560 


Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr 
                565                 570                 575     


Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu 
            580                 585                 590         


Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu 
        595                 600                 605             


Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
    610                 615                 620     


<210>  17
<211>  289
<212>  PRT
<213>  Homo Sapiens

<400>  17

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Val 
                85                  90                  95      


Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg 
            100                 105                 110         


Leu Thr Ile Ile Pro Asn Ile Gln Lys Pro Asp Pro Ala Val Tyr Gln 
        115                 120                 125             


Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp 
    130                 135                 140                 


Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr 
145                 150                 155                 160 


Ile Thr Asp Lys Thr Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser 
                165                 170                 175     


Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn 
            180                 185                 190         


Ala Phe Asn Asn Ser Ile Ile Pro Ala Asp Thr Phe Phe Pro Ser Pro 
        195                 200                 205             


Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp 
    210                 215                 220                 


Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu 
225                 230                 235                 240 


Leu Leu Lys Val Ala Gly Phe Tyr Leu Leu Met Thr Leu Arg Leu Trp 
                245                 250                 255     


Ser Ser Val Asp Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
            260                 265                 270         


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Leu 
        275                 280                 285             


Glu 
    


<210>  18
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  18

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Val 
                85                  90                  95      


Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg 
            100                 105                 110         


Leu Thr Ile Ile Pro 
        115         


<210>  19
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  19

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile 
            20  


<210>  20
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  20

Thr Ser Asp Pro Ser Tyr Gly 
1               5           


<210>  21
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  21

Gln Gly Ser Tyr Asp Gln Gln Asn 
1               5               


<210>  22
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  22

Ala Met Arg Val Ile Ser Asn Phe Gly Asn Glu Lys Leu Thr 
1               5                   10                  


<210>  23
<211>  293
<212>  PRT
<213>  Homo Sapiens

<400>  23

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Leu 
                85                  90                  95      


Gly Gly Gly Thr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
        115                 120                 125             


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
    130                 135                 140                 


Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp 
145                 150                 155                 160 


Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro 
                165                 170                 175     


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
            180                 185                 190         


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
        195                 200                 205             


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
    210                 215                 220                 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
225                 230                 235                 240 


Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
                245                 250                 255     


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
            260                 265                 270         


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
        275                 280                 285             


Lys Asp Ser Arg Gly 
    290             


<210>  24
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  24

Glu Pro Glu Val Thr Gln Thr Pro Ser His Gln Val Thr Gln Met Gly 
1               5                   10                  15      


Gln Glu Val Ile Leu Arg Cys Val Pro Ile Ser Asn His Leu Tyr Phe 
            20                  25                  30          


Tyr Trp Tyr Arg Gln Ile Leu Gly Gln Lys Val Glu Phe Leu Val Ser 
        35                  40                  45              


Phe Tyr Asn Asn Glu Ile Ser Glu Lys Ser Glu Ile Phe Asp Asp Gln 
    50                  55                  60                  


Phe Ser Val Glu Arg Pro Asp Gly Ser Asn Phe Thr Leu Lys Ile Arg 
65                  70                  75                  80  


Ser Thr Lys Leu Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Leu 
                85                  90                  95      


Gly Gly Gly Thr Tyr Glu Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr 
            100                 105                 110         


Val Thr 
        


<210>  25
<211>  19
<212>  PRT
<213>  Homo Sapiens

<400>  25

Met Asp Thr Trp Leu Val Cys Trp Ala Ile Phe Ser Leu Leu Lys Ala 
1               5                   10                  15      


Gly Leu Thr 
            


<210>  26
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  26

Ser Asn His Leu Tyr 
1               5   


<210>  27
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  27

Phe Tyr Asn Asn Glu Ile 
1               5       


<210>  28
<211>  13
<212>  PRT
<213>  Homo Sapiens

<400>  28

Ala Ser Ser Leu Gly Gly Gly Thr Tyr Glu Gln Tyr Phe 
1               5                   10              


<210>  29
<211>  1842
<212>  DNA
<213>  Homo Sapiens

<400>  29
atgctgttct ccagcctgct gtgtgtattt gtggccttca gctactctgg atcaagtgtg       60

gcccagaagg ttactcaagc ccagtcatca gtatccatgc cagtgaggaa agcagtcacc      120

ctgaactgcc tgtatgaaac aagttggtgg tcatattata ttttttggta caagcaactt      180

cccagcaaag agatgatttt ccttattcgc cagggttctg atgaacagaa tgcaaaaagt      240

ggtcgctatt ctgtcaactt caagaaagca gcgaaatccg tcgccttaac catttcagcc      300

ttacagctag aagattcagc aaagtacttt tgtgctcttg gggatagcaa ctatcagtta      360

atctggggcg ctgggaccaa gctaattata aagccagata tccagaaccc tgaccctgcc      420

gtgtaccagc tgagagactc taaatccagt gacaagtctg tctgcctatt caccgatttt      480

gattctcaaa caaatgtgtc acaaagtaag gattctgatg tgtatatcac agacaaatgc      540

gtgctagaca tgaggtctat ggacttcaag agcaacagtg ctgtggcctg gagcaacaaa      600

tctgactttg catgtgcaaa cgccttcaac aacagcatta ttccagaaga caccttcttc      660

cccagcccag aaagttcctg tgatgtcaag ctggtcgaga aaagctttga aacagatacg      720

aacctaaact ttcaaaacct gtcagtgatt gggttccgaa tcctcctcct gaaagtggcc      780

gggtttaatc tgctcatgac gctgcggctg tggtccagcc gtgccaagcg aagcggatct      840

ggcgccacga acttctctct gttaaagcaa gcaggagatg ttgaagaaaa ccccgggcct      900

atggactcct ggaccttctg ctgtgtgtcc ctttgcatcc tggtagcgaa gcatacagat      960

gctggagtta tccagtcacc ccgccatgag gtgacagaga tgggacaaga agtgactctg     1020

agatgtaaac caatttcagg ccacaactcc cttttctggt acagacagac catgatgcgg     1080

ggactggagt tgctcattta ctttaacaac aacgttccga tagatgattc agggatgccc     1140

gaggatcgat tctcagctaa gatgcctaat gcatcattct ccactctgaa gatccagccc     1200

tcagaaccca gggactcagc tgtgtacttc tgtgccagca gagccgggac aggggaggtc     1260

aatgagcagt tcttcgggcc agggacacgg ctcaccgtgc tagaggacct gaaaaacgtg     1320

ttcccacccg aggtcgctgt gtttgagcca tcagaagcag agatctccca cacccaaaag     1380

gccacactgg tgtgcctggc cacaggcttc taccccgacc acgtggagct gagctggtgg     1440

gtgaatggga aggaggtgca cagtggggtc tgcacagacc cgcagcccct caaggagcag     1500

cccgccctca atgactccag atactgcctg agcagccgcc tgagggtctc ggccaccttc     1560

tggcagaacc cccgcaacca cttccgctgt caagtccagt tctacgggct ctcggagaat     1620

gacgagtgga cccaggatag ggccaaacct gtcacccaga tcgtcagcgc cgaggcctgg     1680

ggtagagcag actgtggctt cacctccgag tcttaccagc aaggggtcct gtctgccacc     1740

atcctctatg agatcttgct agggaaggcc accttgtatg ccgtgctggt cagtgccctc     1800

gtgctgatgg ccatggtcaa gagaaaggat tccagaggct aa                        1842


<210>  30
<211>  613
<212>  PRT
<213>  Homo Sapiens

<400>  30

Met Leu Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr Ser 
1               5                   10                  15      


Gly Ser Ser Val Ala Gln Lys Val Thr Gln Ala Gln Ser Ser Val Ser 
            20                  25                  30          


Met Pro Val Arg Lys Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser 
        35                  40                  45              


Trp Trp Ser Tyr Tyr Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser 
65                  70                  75                  80  


Gly Arg Tyr Ser Val Asn Phe Lys Lys Ala Ala Lys Ser Val Ala Leu 
                85                  90                  95      


Thr Ile Ser Ala Leu Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala 
            100                 105                 110         


Leu Gly Asp Ser Asn Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Ile Ile Lys Pro Asp Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile 
                165                 170                 175     


Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn 
            180                 185                 190         


Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala 
        195                 200                 205             


Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu 
    210                 215                 220                 


Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr 
225                 230                 235                 240 


Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu 
                245                 250                 255     


Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser 
            260                 265                 270         


Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
        275                 280                 285             


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Asp Ser Trp 
    290                 295                 300                 


Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala Lys His Thr Asp 
305                 310                 315                 320 


Ala Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln 
                325                 330                 335     


Glu Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe 
            340                 345                 350         


Trp Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe 
        355                 360                 365             


Asn Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe 
    370                 375                 380                 


Ser Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro 
385                 390                 395                 400 


Ser Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Ala Gly 
                405                 410                 415     


Thr Gly Glu Val Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr 
            420                 425                 430         


Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe 
        435                 440                 445             


Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val 
    450                 455                 460                 


Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp 
465                 470                 475                 480 


Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro 
                485                 490                 495     


Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser 
            500                 505                 510         


Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe 
        515                 520                 525             


Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr 
    530                 535                 540                 


Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp 
545                 550                 555                 560 


Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val 
                565                 570                 575     


Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu 
            580                 585                 590         


Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg 
        595                 600                 605             


Lys Asp Ser Arg Gly 
    610             


<210>  31
<211>  279
<212>  PRT
<213>  Homo Sapiens

<400>  31

Gln Lys Val Thr Gln Ala Gln Ser Ser Val Ser Met Pro Val Arg Lys 
1               5                   10                  15      


Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr Tyr 
            20                  25                  30          


Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu Met Ile Phe Leu Ile 
        35                  40                  45              


Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val 
    50                  55                  60                  


Asn Phe Lys Lys Ala Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu 
65                  70                  75                  80  


Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala Leu Gly Asp Ser Asn 
                85                  90                  95      


Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro Asp 
            100                 105                 110         


Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
        115                 120                 125             


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
    130                 135                 140                 


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val 
145                 150                 155                 160 


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
                165                 170                 175     


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
            180                 185                 190         


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
        195                 200                 205             


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
    210                 215                 220                 


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
225                 230                 235                 240 


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg 
                245                 250                 255     


Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
            260                 265                 270         


Val Glu Glu Asn Pro Gly Pro 
        275                 


<210>  32
<211>  112
<212>  PRT
<213>  Homo Sapiens

<400>  32

Gln Lys Val Thr Gln Ala Gln Ser Ser Val Ser Met Pro Val Arg Lys 
1               5                   10                  15      


Ala Val Thr Leu Asn Cys Leu Tyr Glu Thr Ser Trp Trp Ser Tyr Tyr 
            20                  25                  30          


Ile Phe Trp Tyr Lys Gln Leu Pro Ser Lys Glu Met Ile Phe Leu Ile 
        35                  40                  45              


Arg Gln Gly Ser Asp Glu Gln Asn Ala Lys Ser Gly Arg Tyr Ser Val 
    50                  55                  60                  


Asn Phe Lys Lys Ala Ala Lys Ser Val Ala Leu Thr Ile Ser Ala Leu 
65                  70                  75                  80  


Gln Leu Glu Asp Ser Ala Lys Tyr Phe Cys Ala Leu Gly Asp Ser Asn 
                85                  90                  95      


Tyr Gln Leu Ile Trp Gly Ala Gly Thr Lys Leu Ile Ile Lys Pro Asp 
            100                 105                 110         


<210>  33
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  33

Met Leu Phe Ser Ser Leu Leu Cys Val Phe Val Ala Phe Ser Tyr Ser 
1               5                   10                  15      


Gly Ser Ser Val Ala 
            20      


<210>  34
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  34

Thr Ser Trp Trp Ser Tyr Tyr 
1               5           


<210>  35
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  35

Gln Gly Ser Asp Glu Gln Asn Ala 
1               5               


<210>  36
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  36

Leu Gly Asp Ser Asn Tyr Gln Leu Ile 
1               5                   


<210>  37
<211>  292
<212>  PRT
<213>  Homo Sapiens

<400>  37

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
        35                  40                  45              


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Ala Gly Thr 
                85                  90                  95      


Gly Glu Val Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu 
        115                 120                 125             


Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys 
    130                 135                 140                 


Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val 
145                 150                 155                 160 


Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu 
                165                 170                 175     


Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg 
            180                 185                 190         


Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg 
        195                 200                 205             


Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln 
    210                 215                 220                 


Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly 
225                 230                 235                 240 


Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu 
                245                 250                 255     


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
            260                 265                 270         


Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys 
        275                 280                 285             


Asp Ser Arg Gly 
    290         


<210>  38
<211>  113
<212>  PRT
<213>  Homo Sapiens

<400>  38

Gly Val Ile Gln Ser Pro Arg His Glu Val Thr Glu Met Gly Gln Glu 
1               5                   10                  15      


Val Thr Leu Arg Cys Lys Pro Ile Ser Gly His Asn Ser Leu Phe Trp 
            20                  25                  30          


Tyr Arg Gln Thr Met Met Arg Gly Leu Glu Leu Leu Ile Tyr Phe Asn 
        35                  40                  45              


Asn Asn Val Pro Ile Asp Asp Ser Gly Met Pro Glu Asp Arg Phe Ser 
    50                  55                  60                  


Ala Lys Met Pro Asn Ala Ser Phe Ser Thr Leu Lys Ile Gln Pro Ser 
65                  70                  75                  80  


Glu Pro Arg Asp Ser Ala Val Tyr Phe Cys Ala Ser Arg Ala Gly Thr 
                85                  90                  95      


Gly Glu Val Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
            100                 105                 110         


Leu 
    


<210>  39
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  39

Met Asp Ser Trp Thr Phe Cys Cys Val Ser Leu Cys Ile Leu Val Ala 
1               5                   10                  15      


Lys His Thr Asp Ala 
            20      


<210>  40
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  40

Ser Gly His Asn Ser 
1               5   


<210>  41
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  41

Phe Asn Asn Asn Val Pro 
1               5       


<210>  42
<211>  13
<212>  PRT
<213>  Homo Sapiens

<400>  42

Ala Ser Arg Ala Gly Thr Gly Glu Val Asn Glu Gln Phe 
1               5                   10              


<210>  43
<211>  1854
<212>  DNA
<213>  Homo Sapiens

<400>  43
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcaa agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgacgagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtat ttctgtgcaa tgagagaggt ctttggaaat      360

gagaaattaa cctttgggac tggaacaaga ctcaccatca tacccaatat ccagaaccct      420

gaccctgccg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc      480

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca      540

gacaaatgcg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg      600

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac      660

accttcttcc ccagcccaga aagttcctgt gatgtcaagc tggtcgagaa aagctttgaa      720

acagatacga acctaaactt tcaaaacctg tcagtgattg ggttccgaat cctcctcctg      780

aaagtggccg ggtttaatct gctcatgacg ctgcggctgt ggtccagccg tgccaagcga      840

agcggatctg gcgccacgaa cttctctctg ttaaagcaag caggagatgt tgaagaaaac      900

cccgggccta tgagcccaat attcacctgc atcacaatcc tttgtctgct ggctgcaggt      960

tctcctggtg aagaagtcgc ccagactcca aaacatcttg tcagagggga aggacagaaa     1020

gcaaaattat attgtgcccc aataaaagga cacagttatg ttttttggta ccaacaggtc     1080

ctgaaaaacg agttcaagtt cttgatttcc ttccagaatg aaaatgtctt tgatgaaaca     1140

ggtatgccca aggaaagatt ttcagctaag tgcctcccaa attcaccctg tagccttgag     1200

atccaggcta cgaagcttga ggattcagca gtgtattttt gtgccagcag ccctcctccc     1260

tcaaacacct acaatgagca gttcttcggg ccagggacac ggctcaccgt gctagaggac     1320

ctgaaaaacg tgttcccacc cgaggtcgct gtgtttgagc catcagaagc agagatctcc     1380

cacacccaaa aggccacact ggtgtgcctg gccacaggct tctaccccga ccacgtggag     1440

ctgagctggt gggtgaatgg gaaggaggtg cacagtgggg tctgcacaga cccgcagccc     1500

ctcaaggagc agcccgccct caatgactcc agatactgcc tgagcagccg cctgagggtc     1560

tcggccacct tctggcagaa cccccgcaac cacttccgct gtcaagtcca gttctacggg     1620

ctctcggaga atgacgagtg gacccaggat agggccaaac ctgtcaccca gatcgtcagc     1680

gccgaggcct ggggtagagc agactgtggc ttcacctccg agtcttacca gcaaggggtc     1740

ctgtctgcca ccatcctcta tgagatcttg ctagggaagg ccaccttgta tgccgtgctg     1800

gtcagtgccc tcgtgctgat ggccatggtc aagagaaagg attccagagg ctaa           1854


<210>  44
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  44

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Glu Val Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
        275                 280                 285             


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    290                 295                 300                 


Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala Gly 
305                 310                 315                 320 


Ser Pro Gly Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg Gly 
                325                 330                 335     


Glu Gly Gln Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His Ser 
            340                 345                 350         


Tyr Val Phe Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe Leu 
        355                 360                 365             


Ile Ser Phe Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro Lys 
    370                 375                 380                 


Glu Arg Phe Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu Glu 
385                 390                 395                 400 


Ile Gln Ala Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser 
                405                 410                 415     


Ser Pro Pro Pro Ser Asn Thr Tyr Asn Glu Gln Phe Phe Gly Pro Gly 
            420                 425                 430         


Thr Arg Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
        435                 440                 445             


Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys 
    450                 455                 460                 


Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu 
465                 470                 475                 480 


Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr 
                485                 490                 495     


Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr 
            500                 505                 510         


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro 
        515                 520                 525             


Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn 
    530                 535                 540                 


Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser 
545                 550                 555                 560 


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr 
                565                 570                 575     


Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
            580                 585                 590         


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala 
        595                 600                 605             


Met Val Lys Arg Lys Asp Ser Arg Gly 
    610                 615         


<210>  45
<211>  282
<212>  PRT
<213>  Homo Sapiens

<400>  45

Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys Glu 
1               5                   10                  15      


Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln Ser Tyr Gly 
            20                  25                  30          


Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu Ile 
        35                  40                  45              


Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly Arg Tyr Ser 
    50                  55                  60                  


Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser Ala 
65                  70                  75                  80  


Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Glu Val 
                85                  90                  95      


Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile 
            100                 105                 110         


Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp 
        115                 120                 125             


Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser 
    130                 135                 140                 


Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp 
145                 150                 155                 160 


Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala 
                165                 170                 175     


Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn 
            180                 185                 190         


Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser 
        195                 200                 205             


Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu 
    210                 215                 220                 


Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys 
225                 230                 235                 240 


Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser Arg 
                245                 250                 255     


Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
            260                 265                 270         


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        275                 280         


<210>  46
<211>  114
<212>  PRT
<213>  Homo Sapiens

<400>  46

Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys Glu 
1               5                   10                  15      


Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln Ser Tyr Gly 
            20                  25                  30          


Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu Ile 
        35                  40                  45              


Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly Arg Tyr Ser 
    50                  55                  60                  


Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser Ala 
65                  70                  75                  80  


Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Glu Val 
                85                  90                  95      


Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr Ile 
            100                 105                 110         


Ile Pro 
        


<210>  47
<211>  21
<212>  PRT
<213>  Homo Sapiens

<400>  47

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala 
            20      


<210>  48
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  48

Thr Ser Asp Gln Ser Tyr Gly 
1               5           


<210>  49
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  49

Gln Gly Ser Tyr Asp Glu Gln Asn 
1               5               


<210>  50
<211>  12
<212>  PRT
<213>  Homo Sapiens

<400>  50

Ala Met Arg Glu Val Phe Gly Asn Glu Lys Leu Thr 
1               5                   10          


<210>  51
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  51

Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg Gly Glu Gly Gln 
1               5                   10                  15      


Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His Ser Tyr Val Phe 
            20                  25                  30          


Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe Leu Ile Ser Phe 
        35                  40                  45              


Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro Lys Glu Arg Phe 
    50                  55                  60                  


Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu Glu Ile Gln Ala 
65                  70                  75                  80  


Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Pro 
                85                  90                  95      


Pro Ser Asn Thr Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val 
        115                 120                 125             


Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu 
    130                 135                 140                 


Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp 
145                 150                 155                 160 


Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro Gln 
                165                 170                 175     


Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser 
            180                 185                 190         


Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His 
        195                 200                 205             


Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp 
    210                 215                 220                 


Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala 
225                 230                 235                 240 


Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly 
                245                 250                 255     


Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr 
            260                 265                 270         


Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys 
        275                 280                 285             


Arg Lys Asp Ser Arg Gly 
    290                 


<210>  52
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  52

Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg Gly Glu Gly Gln 
1               5                   10                  15      


Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His Ser Tyr Val Phe 
            20                  25                  30          


Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe Leu Ile Ser Phe 
        35                  40                  45              


Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro Lys Glu Arg Phe 
    50                  55                  60                  


Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu Glu Ile Gln Ala 
65                  70                  75                  80  


Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser Pro Pro 
                85                  90                  95      


Pro Ser Asn Thr Tyr Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
            100                 105                 110         


Thr Val Leu 
        115 


<210>  53
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  53

Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly 
            20  


<210>  54
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  54

Lys Gly His Ser Tyr 
1               5   


<210>  55
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  55

Phe Gln Asn Glu Asn Val 
1               5       


<210>  56
<211>  14
<212>  PRT
<213>  Homo Sapiens

<400>  56

Ala Ser Ser Pro Pro Pro Ser Asn Thr Tyr Asn Glu Gln Phe 
1               5                   10                  


<210>  57
<211>  1854
<212>  DNA
<213>  Homo Sapiens

<400>  57
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcaa agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgacgagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtat ttctgtgcaa tgagagaggt ctttggaaat      360

gagaaattaa cctttgggac tggaacaaga ctcaccatca tacccaatat ccagaaccct      420

gaccctgccg tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc      480

accgattttg attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca      540

gacaaatgcg tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg      600

agcaacaaat ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac      660

accttcttcc ccagcccaga aagttcctgt gatgtcaagc tggtcgagaa aagctttgaa      720

acagatacga acctaaactt tcaaaacctg tcagtgattg ggttccgaat cctcctcctg      780

aaagtggccg ggtttaatct gctcatgacg ctgcggctgt ggtccagccg tgccaagcga      840

agcggatctg gcgccacgaa cttctctctg ttaaagcaag caggagatgt tgaagaaaac      900

cccgggccta tgagcccaat attcacctgc atcacaatcc tttgtctgct ggctgcaggt      960

tctcctggtg aagaagtcgc ccagactcca aaacatcttg tcagagggga aggacagaaa     1020

gcaaaattat attgtgcccc aataaaagga cacagttatg ttttttggta ccaacaggtc     1080

ctgaaaaacg agttcaagtt cttgatttcc ttccagaatg aaaatgtctt tgatgaaaca     1140

ggtatgccca agggaagatt ttcagctaag tgcctcccaa attcaccctg tagccttgag     1200

atccaggcta cgaagcttga ggattcagca gtgtattttt gtgccagcag ccatagaagt     1260

tggaaggggg gtgatacgca gccccagcat tttggtgatg ggactcgact ctccatccta     1320

gaggacctga acaaggtgtt cccacccgag gtcgctgtgt ttgagccatc agaagcagag     1380

atctcccaca cccaaaaggc cacactggtg tgcctggcca caggcttctt ccctgaccac     1440

gtggagctga gctggtgggt gaatgggaag gaggtgcaca gtggggtctg cacggacccg     1500

cagcccctca aggagcagcc cgccctcaat gactccagat actgcctgag cagccgcctg     1560

agggtctcgg ccaccttctg gcagaacccc cgcaaccact tccgctgtca agtccagttc     1620

tacgggctct cggagaatga cgagtggacc caggataggg ccaaacccgt cacccagatc     1680

gtcagcgccg aggcctgggg tagagcagac tgtggcttta cctcggtgtc ctaccagcaa     1740

ggggtcctgt ctgccaccat cctctatgag atcctgctag ggaaggccac cctgtatgct     1800

gtgctggtca gcgcccttgt gttgatggcc atggtcaaga gaaaggattt ctga           1854


<210>  58
<211>  617
<212>  PRT
<213>  Homo Sapiens

<400>  58

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Gln Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Glu Val Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly 
        115                 120                 125             


Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
    130                 135                 140                 


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
145                 150                 155                 160 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
                165                 170                 175     


Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe 
            180                 185                 190         


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
        195                 200                 205             


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
    210                 215                 220                 


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
225                 230                 235                 240 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
                245                 250                 255     


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
            260                 265                 270         


Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
        275                 280                 285             


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met 
    290                 295                 300                 


Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala Gly 
305                 310                 315                 320 


Ser Pro Gly Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg Gly 
                325                 330                 335     


Glu Gly Gln Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His Ser 
            340                 345                 350         


Tyr Val Phe Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe Leu 
        355                 360                 365             


Ile Ser Phe Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro Lys 
    370                 375                 380                 


Gly Arg Phe Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu Glu 
385                 390                 395                 400 


Ile Gln Ala Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser 
                405                 410                 415     


Ser His Arg Ser Trp Lys Gly Gly Asp Thr Gln Pro Gln His Phe Gly 
            420                 425                 430         


Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro 
        435                 440                 445             


Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr 
    450                 455                 460                 


Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His 
465                 470                 475                 480 


Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val 
                485                 490                 495     


Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser 
            500                 505                 510         


Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln 
        515                 520                 525             


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser 
    530                 535                 540                 


Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile 
545                 550                 555                 560 


Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val 
                565                 570                 575     


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
            580                 585                 590         


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu 
        595                 600                 605             


Met Ala Met Val Lys Arg Lys Asp Phe 
    610                 615         


<210>  59
<211>  283
<212>  PRT
<213>  Homo Sapiens

<400>  59

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Glu 
                85                  90                  95      


Val Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr 
            100                 105                 110         


Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg 
        115                 120                 125             


Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp 
    130                 135                 140                 


Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr 
145                 150                 155                 160 


Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser 
                165                 170                 175     


Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe 
            180                 185                 190         


Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser 
        195                 200                 205             


Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn 
    210                 215                 220                 


Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu 
225                 230                 235                 240 


Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 250                 255     


Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
            260                 265                 270         


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        275                 280             


<210>  60
<211>  115
<212>  PRT
<213>  Homo Sapiens

<400>  60

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Gln Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Glu Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Glu 
                85                  90                  95      


Val Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly Thr Arg Leu Thr 
            100                 105                 110         


Ile Ile Pro 
        115 


<210>  61
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  61

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile 
            20  


<210>  62
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  62

Thr Ser Asp Gln Ser Tyr Gly 
1               5           


<210>  63
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  63

Gln Gly Ser Tyr Asp Glu Gln Asn 
1               5               


<210>  64
<211>  12
<212>  PRT
<213>  Homo Sapiens

<400>  64

Ala Met Arg Glu Val Phe Gly Asn Glu Lys Leu Thr 
1               5                   10          


<210>  65
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  65

Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg Gly Glu Gly Gln 
1               5                   10                  15      


Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His Ser Tyr Val Phe 
            20                  25                  30          


Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe Leu Ile Ser Phe 
        35                  40                  45              


Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro Lys Gly Arg Phe 
    50                  55                  60                  


Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu Glu Ile Gln Ala 
65                  70                  75                  80  


Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser His Arg 
                85                  90                  95      


Ser Trp Lys Gly Gly Asp Thr Gln Pro Gln His Phe Gly Asp Gly Thr 
            100                 105                 110         


Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
        115                 120                 125             


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
    130                 135                 140                 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
145                 150                 155                 160 


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
                165                 170                 175     


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
            180                 185                 190         


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
        195                 200                 205             


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
    210                 215                 220                 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
225                 230                 235                 240 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
                245                 250                 255     


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
            260                 265                 270         


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
        275                 280                 285             


Val Lys Arg Lys Asp Phe 
    290                 


<210>  66
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  66

Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg Gly Glu Gly Gln 
1               5                   10                  15      


Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His Ser Tyr Val Phe 
            20                  25                  30          


Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe Leu Ile Ser Phe 
        35                  40                  45              


Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro Lys Gly Arg Phe 
    50                  55                  60                  


Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu Glu Ile Gln Ala 
65                  70                  75                  80  


Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser His Arg 
                85                  90                  95      


Ser Trp Lys Gly Gly Asp Thr Gln Pro Gln His Phe Gly Asp Gly Thr 
            100                 105                 110         


Arg Leu Ser Ile Leu 
        115         


<210>  67
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  67

Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly 
            20  


<210>  68
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  68

Lys Gly His Ser Tyr 
1               5   


<210>  69
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  69

Phe Gln Asn Glu Asn Val 
1               5       


<210>  70
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  70

Ala Ser Ser His Arg Ser Trp Lys Gly Gly Asp Thr Gln Pro Gln His 
1               5                   10                  15      


<210>  71
<211>  1866
<212>  DNA
<213>  Homo Sapiens

<400>  71
atgtcacttt ctagcctgct gaaggtggtc acagcttcac tgtggctagg acctggcatt       60

gcccagaaga taactcaaac ccaaccagga atgttcgtgc aggaaaagga ggctgtgact      120

ctggactgca catatgacac cagtgatcca agttatggtc tattctggta caagcagccc      180

agcagtgggg aaatgatttt tcttatttat caggggtctt atgaccagca aaatgcaaca      240

gaaggtcgct actcattgaa tttccagaag gcaagaaaat ccgccaacct tgtcatctcc      300

gcttcacaac tgggggactc agcaatgtac ttctgtgcaa tgaggagtgg gcatctgtct      360

aactttggaa atgagaaatt aacctttggg actggaacaa gactcaccat catacccaat      420

atccagaacc ctgaccctgc cgtgtaccag ctgagagact ctaaatccag tgacaagtct      480

gtctgcctat tcaccgattt tgattctcaa acaaatgtgt cacaaagtaa ggattctgat      540

gtgtatatca cagacaaatg cgtgctagac atgaggtcta tggacttcaa gagcaacagt      600

gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa acgccttcaa caacagcatt      660

attccagaag acaccttctt ccccagccca gaaagttcct gtgatgtcaa gctggtcgag      720

aaaagctttg aaacagatac gaacctaaac tttcaaaacc tgtcagtgat tgggttccga      780

atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct gtggtccagc      840

cgtgccaagc gaagcggatc tggcgccacg aacttctctc tgttaaagca agcaggagat      900

gttgaagaaa accccgggcc tatgagccca atattcacct gcatcacaat cctttgtctg      960

ctggctgcag gttctcctgg tgaagaagtc gcccagactc caaaacatct tgtcagaggg     1020

gaaggacaga aagcaaaatt atattgtgcc ccaataaaag gacacagtta tgttttttgg     1080

taccaacagg tcctgaaaaa cgagttcaag ttcttgattt ccttccagaa tgaaaatgtc     1140

tttgatgaaa caggtatgcc caagggaaga ttttcagcta agtgcctccc aaattcaccc     1200

tgtagccttg agatccaggc tacgaagctt gaggattcag cagtgtattt ttgtgccagc     1260

agccatagaa gttggaaggg gggtgatacg cagccccagc attttggtga tgggactcga     1320

ctctccatcc tagaggacct gaacaaggtg ttcccacccg aggtcgctgt gtttgagcca     1380

tcagaagcag agatctccca cacccaaaag gccacactgg tgtgcctggc cacaggcttc     1440

ttccctgacc acgtggagct gagctggtgg gtgaatggga aggaggtgca cagtggggtc     1500

tgcacggacc cgcagcccct caaggagcag cccgccctca atgactccag atactgcctg     1560

agcagccgcc tgagggtctc ggccaccttc tggcagaacc cccgcaacca cttccgctgt     1620

caagtccagt tctacgggct ctcggagaat gacgagtgga cccaggatag ggccaaaccc     1680

gtcacccaga tcgtcagcgc cgaggcctgg ggtagagcag actgtggctt tacctcggtg     1740

tcctaccagc aaggggtcct gtctgccacc atcctctatg agatcctgct agggaaggcc     1800

accctgtatg ctgtgctggt cagcgccctt gtgttgatgg ccatggtcaa gagaaaggat     1860

ttctga                                                                1866


<210>  72
<211>  621
<212>  PRT
<213>  Homo Sapiens

<400>  72

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe 
            20                  25                  30          


Val Gln Glu Lys Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu 
    50                  55                  60                  


Met Ile Phe Leu Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr 
65                  70                  75                  80  


Glu Gly Arg Tyr Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn 
                85                  90                  95      


Leu Val Ile Ser Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys 
            100                 105                 110         


Ala Met Arg Ser Gly His Leu Ser Asn Phe Gly Asn Glu Lys Leu Thr 
        115                 120                 125             


Phe Gly Thr Gly Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro 
    130                 135                 140                 


Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser 
145                 150                 155                 160 


Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser 
                165                 170                 175     


Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg 
            180                 185                 190         


Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser 
        195                 200                 205             


Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp 
    210                 215                 220                 


Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu 
225                 230                 235                 240 


Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val 
                245                 250                 255     


Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu 
            260                 265                 270         


Met Thr Leu Arg Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly 
        275                 280                 285             


Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
    290                 295                 300                 


Pro Gly Pro Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu 
305                 310                 315                 320 


Leu Ala Ala Gly Ser Pro Gly Glu Glu Val Ala Gln Thr Pro Lys His 
                325                 330                 335     


Leu Val Arg Gly Glu Gly Gln Lys Ala Lys Leu Tyr Cys Ala Pro Ile 
            340                 345                 350         


Lys Gly His Ser Tyr Val Phe Trp Tyr Gln Gln Val Leu Lys Asn Glu 
        355                 360                 365             


Phe Lys Phe Leu Ile Ser Phe Gln Asn Glu Asn Val Phe Asp Glu Thr 
    370                 375                 380                 


Gly Met Pro Lys Gly Arg Phe Ser Ala Lys Cys Leu Pro Asn Ser Pro 
385                 390                 395                 400 


Cys Ser Leu Glu Ile Gln Ala Thr Lys Leu Glu Asp Ser Ala Val Tyr 
                405                 410                 415     


Phe Cys Ala Ser Ser His Arg Ser Trp Lys Gly Gly Asp Thr Gln Pro 
            420                 425                 430         


Gln His Phe Gly Asp Gly Thr Arg Leu Ser Ile Leu Glu Asp Leu Asn 
        435                 440                 445             


Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala Glu 
    450                 455                 460                 


Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly Phe 
465                 470                 475                 480 


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
                485                 490                 495     


His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro Ala 
            500                 505                 510         


Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
        515                 520                 525             


Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
    530                 535                 540                 


Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys Pro 
545                 550                 555                 560 


Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
                565                 570                 575     


Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu 
            580                 585                 590         


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
        595                 600                 605             


Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
    610                 615                 620     


<210>  73
<211>  287
<212>  PRT
<213>  Homo Sapiens

<400>  73

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Ser 
                85                  90                  95      


Gly His Leu Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly 
            100                 105                 110         


Thr Arg Leu Thr Ile Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val 
        115                 120                 125             


Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe 
    130                 135                 140                 


Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp 
145                 150                 155                 160 


Val Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe 
                165                 170                 175     


Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys 
            180                 185                 190         


Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro 
        195                 200                 205             


Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu 
    210                 215                 220                 


Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg 
225                 230                 235                 240 


Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg 
                245                 250                 255     


Leu Trp Ser Ser Arg Ala Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe 
            260                 265                 270         


Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
        275                 280                 285         


<210>  74
<211>  119
<212>  PRT
<213>  Homo Sapiens

<400>  74

Ala Gln Lys Ile Thr Gln Thr Gln Pro Gly Met Phe Val Gln Glu Lys 
1               5                   10                  15      


Glu Ala Val Thr Leu Asp Cys Thr Tyr Asp Thr Ser Asp Pro Ser Tyr 
            20                  25                  30          


Gly Leu Phe Trp Tyr Lys Gln Pro Ser Ser Gly Glu Met Ile Phe Leu 
        35                  40                  45              


Ile Tyr Gln Gly Ser Tyr Asp Gln Gln Asn Ala Thr Glu Gly Arg Tyr 
    50                  55                  60                  


Ser Leu Asn Phe Gln Lys Ala Arg Lys Ser Ala Asn Leu Val Ile Ser 
65                  70                  75                  80  


Ala Ser Gln Leu Gly Asp Ser Ala Met Tyr Phe Cys Ala Met Arg Ser 
                85                  90                  95      


Gly His Leu Ser Asn Phe Gly Asn Glu Lys Leu Thr Phe Gly Thr Gly 
            100                 105                 110         


Thr Arg Leu Thr Ile Ile Pro 
        115                 


<210>  75
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  75

Met Ser Leu Ser Ser Leu Leu Lys Val Val Thr Ala Ser Leu Trp Leu 
1               5                   10                  15      


Gly Pro Gly Ile 
            20  


<210>  76
<211>  7
<212>  PRT
<213>  Homo Sapiens

<400>  76

Thr Ser Asp Pro Ser Tyr Gly 
1               5           


<210>  77
<211>  8
<212>  PRT
<213>  Homo Sapiens

<400>  77

Gln Gly Ser Tyr Asp Gln Gln Asn 
1               5               


<210>  78
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  78

Ala Met Arg Ser Gly His Leu Ser Asn Phe Gly Asn Glu Lys Leu Thr 
1               5                   10                  15      


<210>  79
<211>  294
<212>  PRT
<213>  Homo Sapiens

<400>  79

Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg Gly Glu Gly Gln 
1               5                   10                  15      


Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His Ser Tyr Val Phe 
            20                  25                  30          


Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe Leu Ile Ser Phe 
        35                  40                  45              


Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro Lys Gly Arg Phe 
    50                  55                  60                  


Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu Glu Ile Gln Ala 
65                  70                  75                  80  


Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser His Arg 
                85                  90                  95      


Ser Trp Lys Gly Gly Asp Thr Gln Pro Gln His Phe Gly Asp Gly Thr 
            100                 105                 110         


Arg Leu Ser Ile Leu Glu Asp Leu Asn Lys Val Phe Pro Pro Glu Val 
        115                 120                 125             


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
    130                 135                 140                 


Thr Leu Val Cys Leu Ala Thr Gly Phe Phe Pro Asp His Val Glu Leu 
145                 150                 155                 160 


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp 
                165                 170                 175     


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
            180                 185                 190         


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
        195                 200                 205             


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
    210                 215                 220                 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
225                 230                 235                 240 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln 
                245                 250                 255     


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
            260                 265                 270         


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
        275                 280                 285             


Val Lys Arg Lys Asp Phe 
    290                 


<210>  80
<211>  117
<212>  PRT
<213>  Homo Sapiens

<400>  80

Glu Glu Val Ala Gln Thr Pro Lys His Leu Val Arg Gly Glu Gly Gln 
1               5                   10                  15      


Lys Ala Lys Leu Tyr Cys Ala Pro Ile Lys Gly His Ser Tyr Val Phe 
            20                  25                  30          


Trp Tyr Gln Gln Val Leu Lys Asn Glu Phe Lys Phe Leu Ile Ser Phe 
        35                  40                  45              


Gln Asn Glu Asn Val Phe Asp Glu Thr Gly Met Pro Lys Gly Arg Phe 
    50                  55                  60                  


Ser Ala Lys Cys Leu Pro Asn Ser Pro Cys Ser Leu Glu Ile Gln Ala 
65                  70                  75                  80  


Thr Lys Leu Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser His Arg 
                85                  90                  95      


Ser Trp Lys Gly Gly Asp Thr Gln Pro Gln His Phe Gly Asp Gly Thr 
            100                 105                 110         


Arg Leu Ser Ile Leu 
        115         


<210>  81
<211>  20
<212>  PRT
<213>  Homo Sapiens

<400>  81

Met Ser Pro Ile Phe Thr Cys Ile Thr Ile Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Gly Ser Pro Gly 
            20  


<210>  82
<211>  5
<212>  PRT
<213>  Homo Sapiens

<400>  82

Lys Gly His Ser Tyr 
1               5   


<210>  83
<211>  6
<212>  PRT
<213>  Homo Sapiens

<400>  83

Phe Gln Asn Glu Asn Val 
1               5       


<210>  84
<211>  16
<212>  PRT
<213>  Homo Sapiens

<400>  84

Ala Ser Ser His Arg Ser Trp Lys Gly Gly Asp Thr Gln Pro Gln His 
1               5                   10                  15      


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  85

His Val Lys Ile Thr Asp Phe Gly Arg 
1               5                   


<210>  86
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  86

Gly Ser Gly Gly Ser 
1               5   


<210>  87
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  87

Gly Gly Gly Ser 
1               


<210>  88
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  88

Gly Gly Ser Gly 
1               


<210>  89
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  89

Gly Gly Ser Gly Gly 
1               5   


<210>  90
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  90

Gly Ser Gly Ser Gly 
1               5   


<210>  91
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  91

Gly Ser Gly Gly Gly 
1               5   


<210>  92
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  92

Gly Gly Gly Ser Gly 
1               5   


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  93

Gly Ser Ser Ser Gly 
1               5   


