                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
       Perez-Pinera, Pablo
 
<120>  Split Prime Editing Platforms

<130>  428262-000082

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  1515
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the N-terminal fragment of the split prime
       editor at the linker

<400>  1

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp 
                725                 730                 735     


Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
            740                 745                 750         


Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val 
        755                 760                 765             


Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys 
785                 790                 795                 800 


Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu 
                805                 810                 815     


His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr 
            820                 825                 830         


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 
        835                 840                 845             


Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe 
    850                 855                 860                 


Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 
865                 870                 875                 880 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys 
                885                 890                 895     


Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln 
            900                 905                 910         


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu 
        915                 920                 925             


Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys 
945                 950                 955                 960 


Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu 
                965                 970                 975     


Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys 
            980                 985                 990         


Val Arg Glu Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1025                 1030                 1035             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1040                 1045                 1050             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1055                 1060                 1065             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1070                 1075                 1080             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1085                 1090                 1095             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1100                 1105                 1110             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1115                 1120                 1125             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    1130                 1135                 1140             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    1145                 1150                 1155             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    1160                 1165                 1170             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    1175                 1180                 1185             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    1190                 1195                 1200             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    1205                 1210                 1215             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    1220                 1225                 1230             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    1235                 1240                 1245             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    1250                 1255                 1260             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    1265                 1270                 1275             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    1280                 1285                 1290             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    1295                 1300                 1305             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    1310                 1315                 1320             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    1325                 1330                 1335             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    1340                 1345                 1350             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    1355                 1360                 1365             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    1370                 1375                 1380             


Gly Gly  Asp Ser Gly Gly Ser  Ser Gly Cys Leu Ser  Tyr Glu Thr 
    1385                 1390                 1395             


Glu Ile  Leu Thr Val Glu Tyr  Gly Leu Leu Pro Ile  Gly Lys Ile 
    1400                 1405                 1410             


Val Glu  Lys Arg Ile Glu Cys  Thr Val Tyr Ser Val  Asp Asn Asn 
    1415                 1420                 1425             


Gly Asn  Ile Tyr Thr Gln Pro  Val Ala Gln Trp His  Asp Arg Gly 
    1430                 1435                 1440             


Glu Gln  Glu Val Phe Glu Tyr  Cys Leu Glu Asp Gly  Ser Leu Ile 
    1445                 1450                 1455             


Arg Ala  Thr Lys Asp His Lys  Phe Met Thr Val Asp  Gly Gln Met 
    1460                 1465                 1470             


Leu Pro  Ile Asp Glu Ile Phe  Glu Arg Glu Leu Asp  Leu Met Arg 
    1475                 1480                 1485             


Val Asp  Asn Leu Pro Asn Ser  Gly Gly Ser Lys Arg  Thr Ala Asp 
    1490                 1495                 1500             


Gly Ser  Glu Phe Glu Pro Lys  Lys Lys Arg Lys Val  
    1505                 1510                 1515 


<210>  2
<211>  783
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the C-terminus fragment of the split prime
       editor at the linker

<400>  2

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn 
            20                  25                  30          


Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn 
        35                  40                  45              


Gly Phe Ile Ala Ser Asn Gly Arg Ala Gly Gly Ser Ser Gly Ser Glu 
    50                  55                  60                  


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
65                  70                  75                  80  


Ser Gly Gly Ser Ser Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His 
                85                  90                  95      


Glu Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser 
            100                 105                 110         


Asp Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val 
        115                 120                 125             


Arg Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val 
    130                 135                 140                 


Ser Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys 
145                 150                 155                 160 


Pro His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln 
                165                 170                 175     


Ser Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn 
            180                 185                 190         


Asp Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu 
        195                 200                 205             


Asp Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu 
    210                 215                 220                 


Pro Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe 
225                 230                 235                 240 


Phe Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu 
                245                 250                 255     


Trp Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg 
            260                 265                 270         


Leu Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu 
        275                 280                 285             


His Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu 
    290                 295                 300                 


Leu Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp 
305                 310                 315                 320 


Cys Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly 
                325                 330                 335     


Tyr Arg Ala Ser Ala Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys 
            340                 345                 350         


Tyr Leu Gly Tyr Leu Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala 
        355                 360                 365             


Arg Lys Glu Thr Val Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln 
    370                 375                 380                 


Leu Arg Glu Phe Leu Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro 
385                 390                 395                 400 


Gly Phe Ala Glu Met Ala Ala Pro Leu Tyr Pro Leu Thr Lys Pro Gly 
                405                 410                 415     


Thr Leu Phe Asn Trp Gly Pro Asp Gln Gln Lys Ala Tyr Gln Glu Ile 
            420                 425                 430         


Lys Gln Ala Leu Leu Thr Ala Pro Ala Leu Gly Leu Pro Asp Leu Thr 
        435                 440                 445             


Lys Pro Phe Glu Leu Phe Val Asp Glu Lys Gln Gly Tyr Ala Lys Gly 
    450                 455                 460                 


Val Leu Thr Gln Lys Leu Gly Pro Trp Arg Arg Pro Val Ala Tyr Leu 
465                 470                 475                 480 


Ser Lys Lys Leu Asp Pro Val Ala Ala Gly Trp Pro Pro Cys Leu Arg 
                485                 490                 495     


Met Val Ala Ala Ile Ala Val Leu Thr Lys Asp Ala Gly Lys Leu Thr 
            500                 505                 510         


Met Gly Gln Pro Leu Val Ile Leu Ala Pro His Ala Val Glu Ala Leu 
        515                 520                 525             


Val Lys Gln Pro Pro Asp Arg Trp Leu Ser Asn Ala Arg Met Thr His 
    530                 535                 540                 


Tyr Gln Ala Leu Leu Leu Asp Thr Asp Arg Val Gln Phe Gly Pro Val 
545                 550                 555                 560 


Val Ala Leu Asn Pro Ala Thr Leu Leu Pro Leu Pro Glu Glu Gly Leu 
                565                 570                 575     


Gln His Asn Cys Leu Asp Ile Leu Ala Glu Ala His Gly Thr Arg Pro 
            580                 585                 590         


Asp Leu Thr Asp Gln Pro Leu Pro Asp Ala Asp His Thr Trp Tyr Thr 
        595                 600                 605             


Asp Gly Ser Ser Leu Leu Gln Glu Gly Gln Arg Lys Ala Gly Ala Ala 
    610                 615                 620                 


Val Thr Thr Glu Thr Glu Val Ile Trp Ala Lys Ala Leu Pro Ala Gly 
625                 630                 635                 640 


Thr Ser Ala Gln Arg Ala Glu Leu Ile Ala Leu Thr Gln Ala Leu Lys 
                645                 650                 655     


Met Ala Glu Gly Lys Lys Leu Asn Val Tyr Thr Asp Ser Arg Tyr Ala 
            660                 665                 670         


Phe Ala Thr Ala His Ile His Gly Glu Ile Tyr Arg Arg Arg Gly Trp 
        675                 680                 685             


Leu Thr Ser Glu Gly Lys Glu Ile Lys Asn Lys Asp Glu Ile Leu Ala 
    690                 695                 700                 


Leu Leu Lys Ala Leu Phe Leu Pro Lys Arg Leu Ser Ile Ile His Cys 
705                 710                 715                 720 


Pro Gly His Gln Lys Gly His Ser Ala Glu Ala Arg Gly Asn Arg Met 
                725                 730                 735     


Ala Asp Gln Ala Ala Arg Lys Ala Ala Ile Thr Glu Thr Pro Asp Thr 
            740                 745                 750         


Ser Thr Leu Leu Ile Glu Asn Ser Ser Pro Ser Gly Gly Ser Lys Arg 
        755                 760                 765             


Thr Ala Asp Gly Ser Glu Phe Glu Pro Lys Lys Lys Arg Lys Val 
    770                 775                 780             


<210>  3
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  sequence of the N-terminal fragment of a split intein (Part of 
       SEQ ID NO:1)

<400>  3

Cys Leu Ser Tyr Glu Thr Glu Ile Leu Thr Val Glu Tyr Gly Leu Leu 
1               5                   10                  15      


Pro Ile Gly Lys Ile Val Glu Lys Arg Ile Glu Cys Thr Val Tyr Ser 
            20                  25                  30          


Val Asp Asn Asn Gly Asn Ile Tyr Thr Gln Pro Val Ala Gln Trp His 
        35                  40                  45              


Asp Arg Gly Glu Gln Glu Val Phe Glu Tyr Cys Leu Glu Asp Gly Ser 
    50                  55                  60                  


Leu Ile Arg Ala Thr Lys Asp His Lys Phe Met Thr Val Asp Gly Gln 
65                  70                  75                  80  


Met Leu Pro Ile Asp Glu Ile Phe Glu Arg Glu Leu Asp Leu Met Arg 
                85                  90                  95      


Val Asp Asn Leu Pro Asn 
            100         


<210>  4
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (Part of SEQ ID NO:2)

<400>  4

Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr Asp 
1               5                   10                  15      


Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe Ile 
            20                  25                  30          


Ala Ser Asn Gly Arg Ala Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly 
        35                  40                  45              


Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly 
    50                  55                  60                  


Ser Ser 
65      


<210>  5
<211>  1451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the N-terminus fragment of the Split prime
       editor with the MMLV at the N-terminus

<400>  5

Met Gly Pro Lys Lys Lys Arg Lys Val Gly Gly Ser Ser Thr Leu Asn 
1               5                   10                  15      


Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu Pro Asp Val 
            20                  25                  30          


Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala Glu 
        35                  40                  45              


Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile Pro 
    50                  55                  60                  


Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met Ser 
65                  70                  75                  80  


Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu Asp 
                85                  90                  95      


Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu Leu 
            100                 105                 110         


Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp Leu 
        115                 120                 125             


Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro Asn 
    130                 135                 140                 


Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr Thr 
145                 150                 155                 160 


Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro Thr 
                165                 170                 175     


Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly Ile 
            180                 185                 190         


Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn Ser 
        195                 200                 205             


Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe Arg 
    210                 215                 220                 


Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu Leu 
225                 230                 235                 240 


Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala Leu 
                245                 250                 255     


Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys Ala 
            260                 265                 270         


Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys Glu 
        275                 280                 285             


Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly Gln 
    290                 295                 300                 


Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Lys Ala 
305                 310                 315                 320 


Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala Pro 
                325                 330                 335     


Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro Asp 
            340                 345                 350         


Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala Pro 
        355                 360                 365             


Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val Asp 
    370                 375                 380                 


Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly Pro 
385                 390                 395                 400 


Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val Ala 
                405                 410                 415     


Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val Leu 
            420                 425                 430         


Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile Leu 
        435                 440                 445             


Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg Trp 
    450                 455                 460                 


Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp Thr 
465                 470                 475                 480 


Asp Arg Val Gln Phe Gly Pro Val Val Ala Leu Asn Pro Ala Thr Leu 
                485                 490                 495     


Leu Pro Leu Pro Glu Glu Gly Leu Gln His Asn Cys Leu Asp Ile Leu 
            500                 505                 510         


Ala Glu Ala His Gly Thr Arg Pro Asp Leu Thr Asp Gln Pro Leu Pro 
        515                 520                 525             


Asp Ala Asp His Thr Trp Tyr Thr Asp Gly Ser Ser Leu Leu Gln Glu 
    530                 535                 540                 


Gly Gln Arg Lys Ala Gly Ala Ala Val Thr Thr Glu Thr Glu Val Ile 
545                 550                 555                 560 


Trp Ala Lys Ala Leu Pro Ala Gly Thr Ser Ala Gln Arg Ala Glu Leu 
                565                 570                 575     


Ile Ala Leu Thr Gln Ala Leu Lys Met Ala Glu Gly Lys Lys Leu Asn 
            580                 585                 590         


Val Tyr Thr Asp Ser Arg Tyr Ala Phe Ala Thr Ala His Ile His Gly 
        595                 600                 605             


Glu Ile Tyr Arg Arg Arg Gly Trp Leu Thr Ser Glu Gly Lys Glu Ile 
    610                 615                 620                 


Lys Asn Lys Asp Glu Ile Leu Ala Leu Leu Lys Ala Leu Phe Leu Pro 
625                 630                 635                 640 


Lys Arg Leu Ser Ile Ile His Cys Pro Gly His Gln Lys Gly His Ser 
                645                 650                 655     


Ala Glu Ala Arg Gly Asn Arg Met Ala Asp Gln Ala Ala Arg Lys Ala 
            660                 665                 670         


Ala Ile Thr Glu Thr Pro Asp Thr Ser Thr Leu Leu Ile Glu Asn Ser 
        675                 680                 685             


Ser Pro Ser Gly Gly Ser Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu 
    690                 695                 700                 


Pro Lys Lys Lys Arg Lys Val Ser Gly Gly Ser Ser Gly Gly Ser Ser 
705                 710                 715                 720 


Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser 
                725                 730                 735     


Gly Gly Ser Ser Gly Gly Ser Ser Thr Leu Glu Pro Gly Glu Lys Pro 
            740                 745                 750         


Tyr Lys Cys Pro Glu Cys Gly Lys Ser Phe Ser Gln Ser Gly Ala Leu 
        755                 760                 765             


Thr Arg His Gln Arg Thr His Thr Arg Asp Lys Lys Tyr Ser Ile Gly 
    770                 775                 780                 


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
785                 790                 795                 800 


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
                805                 810                 815     


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
            820                 825                 830         


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
        835                 840                 845             


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
    850                 855                 860                 


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
865                 870                 875                 880 


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
                885                 890                 895     


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
            900                 905                 910         


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
        915                 920                 925             


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
    930                 935                 940                 


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
945                 950                 955                 960 


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
                965                 970                 975     


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
            980                 985                 990         


Ser Lys Ser Arg Arg Leu Glu Asn  Leu Ile Ala Gln Leu  Pro Gly Glu 
        995                 1000                 1005             


Lys Lys  Asn Gly Leu Phe Gly  Asn Leu Ile Ala Leu  Ser Leu Gly 
    1010                 1015                 1020             


Leu Thr  Pro Asn Phe Lys Ser  Asn Phe Asp Leu Ala  Glu Asp Ala 
    1025                 1030                 1035             


Lys Leu  Gln Leu Ser Lys Asp  Thr Tyr Asp Asp Asp  Leu Asp Asn 
    1040                 1045                 1050             


Leu Leu  Ala Gln Ile Gly Asp  Gln Tyr Ala Asp Leu  Phe Leu Ala 
    1055                 1060                 1065             


Ala Lys  Asn Leu Ser Asp Ala  Ile Leu Leu Ser Asp  Ile Leu Arg 
    1070                 1075                 1080             


Val Asn  Thr Glu Ile Thr Lys  Ala Pro Leu Ser Ala  Ser Met Ile 
    1085                 1090                 1095             


Lys Arg  Tyr Asp Glu His His  Gln Asp Leu Thr Leu  Leu Lys Ala 
    1100                 1105                 1110             


Leu Val  Arg Gln Gln Leu Pro  Glu Lys Tyr Lys Glu  Ile Phe Phe 
    1115                 1120                 1125             


Asp Gln  Ser Lys Asn Gly Tyr  Ala Gly Tyr Ile Asp  Gly Gly Ala 
    1130                 1135                 1140             


Ser Gln  Glu Glu Phe Tyr Lys  Phe Ile Lys Pro Ile  Leu Glu Lys 
    1145                 1150                 1155             


Met Asp  Gly Thr Glu Glu Leu  Leu Val Lys Leu Asn  Arg Glu Asp 
    1160                 1165                 1170             


Leu Leu  Arg Lys Gln Arg Thr  Phe Asp Asn Gly Ser  Ile Pro His 
    1175                 1180                 1185             


Gln Ile  His Leu Gly Glu Leu  His Ala Ile Leu Arg  Arg Gln Glu 
    1190                 1195                 1200             


Asp Phe  Tyr Pro Phe Leu Lys  Asp Asn Arg Glu Lys  Ile Glu Lys 
    1205                 1210                 1215             


Ile Leu  Thr Phe Arg Ile Pro  Tyr Tyr Val Gly Pro  Leu Ala Arg 
    1220                 1225                 1230             


Gly Asn  Ser Arg Phe Ala Trp  Met Thr Arg Lys Ser  Glu Glu Thr 
    1235                 1240                 1245             


Ile Thr  Pro Trp Asn Phe Glu  Glu Val Val Asp Lys  Gly Ala Ser 
    1250                 1255                 1260             


Ala Gln  Ser Phe Ile Glu Arg  Met Thr Asn Phe Asp  Lys Asn Leu 
    1265                 1270                 1275             


Pro Asn  Glu Lys Val Leu Pro  Lys His Ser Leu Leu  Tyr Glu Tyr 
    1280                 1285                 1290             


Phe Thr  Val Tyr Asn Glu Leu  Thr Lys Val Lys Tyr  Val Thr Glu 
    1295                 1300                 1305             


Gly Met  Arg Lys Pro Ala Phe  Leu Ser Gly Glu Gln  Lys Lys Ala 
    1310                 1315                 1320             


Ile Val  Asp Leu Leu Phe Lys  Thr Asn Arg Lys Val  Thr Val Lys 
    1325                 1330                 1335             


Gln Leu  Lys Glu Asp Tyr Phe  Lys Lys Ile Glu Cys  Leu Ser Tyr 
    1340                 1345                 1350             


Glu Thr  Glu Ile Leu Thr Val  Glu Tyr Gly Leu Leu  Pro Ile Gly 
    1355                 1360                 1365             


Lys Ile  Val Glu Lys Arg Ile  Glu Cys Thr Val Tyr  Ser Val Asp 
    1370                 1375                 1380             


Asn Asn  Gly Asn Ile Tyr Thr  Gln Pro Val Ala Gln  Trp His Asp 
    1385                 1390                 1395             


Arg Gly  Glu Gln Glu Val Phe  Glu Tyr Cys Leu Glu  Asp Gly Ser 
    1400                 1405                 1410             


Leu Ile  Arg Ala Thr Lys Asp  His Lys Phe Met Thr  Val Asp Gly 
    1415                 1420                 1425             


Gln Met  Leu Pro Ile Asp Glu  Ile Phe Glu Arg Glu  Leu Asp Leu 
    1430                 1435                 1440             


Met Arg  Val Asp Asn Leu Pro  Asn 
    1445                 1450     


<210>  6
<211>  975
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the C-terminus fragment of the Split prime
       editor with the MMLV at the N-terminus

<400>  6

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn 
            20                  25                  30          


Val Tyr Asp Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn 
        35                  40                  45              


Gly Phe Ile Ala Ser Asn Cys Phe Asp Ser Val Glu Ile Ser Gly Val 
    50                  55                  60                  


Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys 
65                  70                  75                  80  


Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile 
                85                  90                  95      


Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met 
            100                 105                 110         


Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val 
        115                 120                 125             


Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser 
    130                 135                 140                 


Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile 
145                 150                 155                 160 


Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln 
                165                 170                 175     


Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala 
            180                 185                 190         


Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu 
        195                 200                 205             


Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val 
    210                 215                 220                 


Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile 
225                 230                 235                 240 


Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys 
                245                 250                 255     


Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu 
            260                 265                 270         


Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln 
        275                 280                 285             


Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr 
    290                 295                 300                 


Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp 
305                 310                 315                 320 


Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys 
                325                 330                 335     


Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro 
            340                 345                 350         


Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu 
        355                 360                 365             


Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala 
    370                 375                 380                 


Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg 
385                 390                 395                 400 


Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu 
                405                 410                 415     


Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg 
            420                 425                 430         


Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg 
        435                 440                 445             


Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His 
    450                 455                 460                 


Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys 
465                 470                 475                 480 


Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr Lys Val 
                485                 490                 495     


Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu Ile Gly Lys 
            500                 505                 510         


Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys 
        515                 520                 525             


Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile 
    530                 535                 540                 


Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp 
545                 550                 555                 560 


Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val 
                565                 570                 575     


Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu 
            580                 585                 590         


Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp 
        595                 600                 605             


Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val 
    610                 615                 620                 


Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser 
625                 630                 635                 640 


Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu 
                645                 650                 655     


Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys 
            660                 665                 670         


Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu 
        675                 680                 685             


Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly 
    690                 695                 700                 


Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala 
705                 710                 715                 720 


Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys 
                725                 730                 735     


Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu 
            740                 745                 750         


Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu 
        755                 760                 765             


Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg 
    770                 775                 780                 


Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly 
785                 790                 795                 800 


Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg 
                805                 810                 815     


Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser 
            820                 825                 830         


Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly 
        835                 840                 845             


Asp Ser Gly Gly Ser Thr Asn Leu Ser Asp Ile Ile Glu Lys Glu Thr 
    850                 855                 860                 


Gly Lys Gln Leu Val Ile Gln Glu Ser Ile Leu Met Leu Pro Glu Glu 
865                 870                 875                 880 


Val Glu Glu Val Ile Gly Asn Lys Pro Glu Ser Asp Ile Leu Val His 
                885                 890                 895     


Thr Ala Tyr Asp Glu Ser Thr Asp Glu Asn Val Met Leu Leu Thr Ser 
            900                 905                 910         


Asp Ala Pro Glu Tyr Lys Pro Trp Ala Leu Val Ile Gln Asp Ser Asn 
        915                 920                 925             


Gly Glu Asn Lys Ile Lys Met Leu Ser Tyr Pro Tyr Asp Val Pro Asp 
    930                 935                 940                 


Tyr Ala Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Tyr Pro Tyr Asp Val 
945                 950                 955                 960 


Pro Asp Tyr Ala Ser Gly Gly Ser Pro Lys Lys Lys Arg Lys Val 
                965                 970                 975 


<210>  7
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fragment of a split intein (Part of SEQ ID NO:6)

<400>  7

Ile Lys Ile Ala Thr Arg Lys Tyr Leu Gly Lys Gln Asn Val Tyr Asp 
1               5                   10                  15      


Ile Gly Val Glu Arg Asp His Asn Phe Ala Leu Lys Asn Gly Phe Ile 
            20                  25                  30          


Ala Ser Asn 
        35  


<210>  8
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Marathon Reverse Transcriptase

<400>  8

Asn Leu Met Glu Gln Ile Leu Ser Ser Asp Asn Leu Asn Arg Ala Tyr 
1               5                   10                  15      


Leu Gln Val Val Arg Asn Lys Gly Ala Glu Gly Val Asp Gly Met Lys 
            20                  25                  30          


Tyr Thr Glu Leu Lys Glu His Leu Ala Lys Asn Gly Glu Thr Ile Lys 
        35                  40                  45              


Gly Gln Leu Arg Thr Arg Lys Tyr Lys Pro Gln Pro Ala Arg Arg Val 
    50                  55                  60                  


Glu Ile Pro Lys Pro Asp Gly Gly Val Arg Asn Leu Gly Val Pro Thr 
65                  70                  75                  80  


Val Thr Asp Arg Phe Ile Gln Gln Ala Ile Ala Gln Val Leu Thr Pro 
                85                  90                  95      


Ile Tyr Glu Glu Gln Phe His Asp His Ser Tyr Gly Phe Arg Pro Asn 
            100                 105                 110         


Arg Cys Ala Gln Gln Ala Ile Leu Thr Ala Leu Asn Ile Met Asn Asp 
        115                 120                 125             


Gly Asn Asp Trp Ile Val Asp Ile Asp Leu Glu Lys Phe Phe Asp Thr 
    130                 135                 140                 


Val Asn His Asp Lys Leu Met Thr Leu Ile Gly Arg Thr Ile Lys Asp 
145                 150                 155                 160 


Gly Asp Val Ile Ser Ile Val Arg Lys Tyr Leu Val Ser Gly Ile Met 
                165                 170                 175     


Ile Asp Asp Glu Tyr Glu Asp Ser Ile Val Gly Thr Pro Gln Gly Gly 
            180                 185                 190         


Asn Leu Ser Pro Leu Leu Ala Asn Ile Met Leu Asn Glu Leu Asp Lys 
        195                 200                 205             


Glu Met Glu Lys Arg Gly Leu Asn Phe Val Arg Tyr Ala Asp Asp Cys 
    210                 215                 220                 


Ile Ile Met Val Gly Ser Glu Met Ser Ala Asn Arg Val Met Arg Asn 
225                 230                 235                 240 


Ile Ser Arg Phe Ile Glu Glu Lys Leu Gly Leu Lys Val Asn Met Thr 
                245                 250                 255     


Lys Ser Lys Val Asp Arg Pro Ser Gly Leu Lys Tyr Leu Gly Phe Gly 
            260                 265                 270         


Phe Tyr Phe Asp Pro Arg Ala His Gln Phe Lys Ala Lys Pro His Ala 
        275                 280                 285             


Lys Ser Val Ala Lys Phe Lys Lys Arg Met Lys Glu Leu Thr Cys Arg 
    290                 295                 300                 


Ser Trp Gly Val Ser Asn Ser Tyr Lys Val Glu Lys Leu Asn Gln Leu 
305                 310                 315                 320 


Ile Arg Gly Trp Ile Asn Tyr Phe Lys Ile Gly Ser Met Lys Thr Leu 
                325                 330                 335     


Cys Lys Glu Leu Asp Ser Arg Ile Arg Tyr Arg Leu Arg Met Cys Ile 
            340                 345                 350         


Trp Lys Gln Trp Lys Thr Pro Gln Asn Gln Glu Lys Asn Leu Val Lys 
        355                 360                 365             


Leu Gly Ile Asp Arg Asn Thr Ala Arg Arg Val Ala Tyr Thr Gly Lys 
    370                 375                 380                 


Arg Ile Ala Tyr Val Cys Asn Lys Gly Ala Val Asn Val Ala Ile Ser 
385                 390                 395                 400 


Asn Lys Arg Leu Ala Ser Phe Gly Leu Ile Ser Met Leu Asp Tyr Tyr 
                405                 410                 415     


Ile Glu Lys Cys Val Thr Cys Glu Phe Glu 
            420                 425     


<210>  9
<211>  833
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus fragment of Split 713

<400>  9

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Cys Leu Ala Gly Asp 
                725                 730                 735     


Thr Leu Ile Thr Leu Ala Asp Gly Arg Arg Val Pro Ile Arg Glu Leu 
            740                 745                 750         


Val Ser Gln Gln Asn Phe Ser Val Trp Ala Leu Asn Pro Gln Thr Tyr 
        755                 760                 765             


Arg Leu Glu Arg Ala Arg Val Ser Arg Ala Phe Cys Thr Gly Ile Lys 
    770                 775                 780                 


Pro Val Tyr Arg Leu Thr Thr Arg Leu Gly Arg Ser Ile Arg Ala Thr 
785                 790                 795                 800 


Ala Asn His Arg Phe Leu Thr Pro Gln Gly Trp Lys Arg Val Asp Glu 
                805                 810                 815     


Leu Gln Pro Gly Asp Tyr Leu Ala Leu Pro Arg Arg Ile Pro Thr Ala 
            820                 825                 830         


Ser 
    


<210>  10
<211>  1438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  10 C-terminus fragment of Split 713

<400>  10

Met Ala Ala Ala Cys Pro Glu Leu Arg Gln Leu Ala Gln Ser Asp Val 
1               5                   10                  15      


Tyr Trp Asp Pro Ile Val Ser Ile Glu Pro Asp Gly Val Glu Glu Val 
            20                  25                  30          


Phe Asp Leu Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile 
        35                  40                  45              


Ile Ala His Asn Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala 
    50                  55                  60                  


Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val 
65                  70                  75                  80  


Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu 
                85                  90                  95      


Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly 
            100                 105                 110         


Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys 
        115                 120                 125             


Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln 
    130                 135                 140                 


Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp 
145                 150                 155                 160 


Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp 
                165                 170                 175     


Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp 
            180                 185                 190         


Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn 
        195                 200                 205             


Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln 
    210                 215                 220                 


Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr 
225                 230                 235                 240 


Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile 
                245                 250                 255     


Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln 
            260                 265                 270         


Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu 
        275                 280                 285             


Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp 
    290                 295                 300                 


Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr 
305                 310                 315                 320 


His His Ala His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu 
                325                 330                 335     


Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr 
            340                 345                 350         


Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu Ile 
        355                 360                 365             


Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe 
    370                 375                 380                 


Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro 
385                 390                 395                 400 


Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly 
                405                 410                 415     


Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn 
            420                 425                 430         


Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser 
        435                 440                 445             


Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp 
    450                 455                 460                 


Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr 
465                 470                 475                 480 


Ser Val Leu Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu 
                485                 490                 495     


Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser 
            500                 505                 510         


Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu 
        515                 520                 525             


Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu 
    530                 535                 540                 


Leu Glu Asn Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln 
545                 550                 555                 560 


Lys Gly Asn Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr 
                565                 570                 575     


Leu Ala Ser His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu 
            580                 585                 590         


Gln Lys Gln Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile 
        595                 600                 605             


Ile Glu Gln Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala 
    610                 615                 620                 


Asn Leu Asp Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro 
625                 630                 635                 640 


Ile Arg Glu Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn 
                645                 650                 655     


Leu Gly Ala Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg 
            660                 665                 670         


Lys Arg Tyr Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His 
        675                 680                 685             


Gln Ser Ile Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu 
    690                 695                 700                 


Gly Gly Asp Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr 
705                 710                 715                 720 


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser 
                725                 730                 735     


Gly Gly Ser Ser Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu 
            740                 745                 750         


Thr Ser Lys Glu Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp 
        755                 760                 765             


Phe Pro Gln Ala Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg 
    770                 775                 780                 


Gln Ala Pro Leu Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser 
785                 790                 795                 800 


Ile Lys Gln Tyr Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro 
                805                 810                 815     


His Ile Gln Arg Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser 
            820                 825                 830         


Pro Trp Asn Thr Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp 
        835                 840                 845             


Tyr Arg Pro Val Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp 
    850                 855                 860                 


Ile His Pro Thr Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro 
865                 870                 875                 880 


Pro Ser His Gln Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe 
                885                 890                 895     


Cys Leu Arg Leu His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp 
            900                 905                 910         


Arg Asp Pro Glu Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu 
        915                 920                 925             


Pro Gln Gly Phe Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His 
    930                 935                 940                 


Arg Asp Leu Ala Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu 
945                 950                 955                 960 


Gln Tyr Val Asp Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys 
                965                 970                 975     


Gln Gln Gly Thr Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr 
            980                 985                 990         


Arg Ala Ser Ala Lys Lys Ala Gln  Ile Cys Gln Lys Gln  Val Lys Tyr 
        995                 1000                 1005             


Leu Gly  Tyr Leu Leu Lys Glu  Gly Gln Arg Trp Leu  Thr Glu Ala 
    1010                 1015                 1020             


Arg Lys  Glu Thr Val Met Gly  Gln Pro Thr Pro Lys  Thr Pro Arg 
    1025                 1030                 1035             


Gln Leu  Arg Glu Phe Leu Gly  Lys Ala Gly Phe Cys  Arg Leu Phe 
    1040                 1045                 1050             


Ile Pro  Gly Phe Ala Glu Met  Ala Ala Pro Leu Tyr  Pro Leu Thr 
    1055                 1060                 1065             


Lys Pro  Gly Thr Leu Phe Asn  Trp Gly Pro Asp Gln  Gln Lys Ala 
    1070                 1075                 1080             


Tyr Gln  Glu Ile Lys Gln Ala  Leu Leu Thr Ala Pro  Ala Leu Gly 
    1085                 1090                 1095             


Leu Pro  Asp Leu Thr Lys Pro  Phe Glu Leu Phe Val  Asp Glu Lys 
    1100                 1105                 1110             


Gln Gly  Tyr Ala Lys Gly Val  Leu Thr Gln Lys Leu  Gly Pro Trp 
    1115                 1120                 1125             


Arg Arg  Pro Val Ala Tyr Leu  Ser Lys Lys Leu Asp  Pro Val Ala 
    1130                 1135                 1140             


Ala Gly  Trp Pro Pro Cys Leu  Arg Met Val Ala Ala  Ile Ala Val 
    1145                 1150                 1155             


Leu Thr  Lys Asp Ala Gly Lys  Leu Thr Met Gly Gln  Pro Leu Val 
    1160                 1165                 1170             


Ile Leu  Ala Pro His Ala Val  Glu Ala Leu Val Lys  Gln Pro Pro 
    1175                 1180                 1185             


Asp Arg  Trp Leu Ser Asn Ala  Arg Met Thr His Tyr  Gln Ala Leu 
    1190                 1195                 1200             


Leu Leu  Asp Thr Asp Arg Val  Gln Phe Gly Pro Val  Val Ala Leu 
    1205                 1210                 1215             


Asn Pro  Ala Thr Leu Leu Pro  Leu Pro Glu Glu Gly  Leu Gln His 
    1220                 1225                 1230             


Asn Cys  Leu Asp Ile Leu Ala  Glu Ala His Gly Thr  Arg Pro Asp 
    1235                 1240                 1245             


Leu Thr  Asp Gln Pro Leu Pro  Asp Ala Asp His Thr  Trp Tyr Thr 
    1250                 1255                 1260             


Asp Gly  Ser Ser Leu Leu Gln  Glu Gly Gln Arg Lys  Ala Gly Ala 
    1265                 1270                 1275             


Ala Val  Thr Thr Glu Thr Glu  Val Ile Trp Ala Lys  Ala Leu Pro 
    1280                 1285                 1290             


Ala Gly  Thr Ser Ala Gln Arg  Ala Glu Leu Ile Ala  Leu Thr Gln 
    1295                 1300                 1305             


Ala Leu  Lys Met Ala Glu Gly  Lys Lys Leu Asn Val  Tyr Thr Asp 
    1310                 1315                 1320             


Ser Arg  Tyr Ala Phe Ala Thr  Ala His Ile His Gly  Glu Ile Tyr 
    1325                 1330                 1335             


Arg Arg  Arg Gly Trp Leu Thr  Ser Glu Gly Lys Glu  Ile Lys Asn 
    1340                 1345                 1350             


Lys Asp  Glu Ile Leu Ala Leu  Leu Lys Ala Leu Phe  Leu Pro Lys 
    1355                 1360                 1365             


Arg Leu  Ser Ile Ile His Cys  Pro Gly His Gln Lys  Gly His Ser 
    1370                 1375                 1380             


Ala Glu  Ala Arg Gly Asn Arg  Met Ala Asp Gln Ala  Ala Arg Lys 
    1385                 1390                 1395             


Ala Ala  Ile Thr Glu Thr Pro  Asp Thr Ser Thr Leu  Leu Ile Glu 
    1400                 1405                 1410             


Asn Ser  Ser Pro Ser Gly Gly  Ser Lys Arg Thr Ala  Asp Gly Ser 
    1415                 1420                 1425             


Glu Phe  Glu Pro Lys Lys Lys  Arg Lys Val 
    1430                 1435             


<210>  11
<211>  1060
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11 N-terminus fragment of Split 945

<400>  11

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Lys Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp 
                725                 730                 735     


Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
            740                 745                 750         


Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val 
        755                 760                 765             


Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys 
785                 790                 795                 800 


Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu 
                805                 810                 815     


His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr 
            820                 825                 830         


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 
        835                 840                 845             


Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe 
    850                 855                 860                 


Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 
865                 870                 875                 880 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys 
                885                 890                 895     


Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln 
            900                 905                 910         


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu 
        915                 920                 925             


Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Cys Leu 
945                 950                 955                 960 


Ala Gly Asp Thr Leu Ile Thr Leu Ala Asp Gly Arg Arg Val Pro Ile 
                965                 970                 975     


Arg Glu Leu Val Ser Gln Gln Asn Phe Ser Val Trp Ala Leu Asn Pro 
            980                 985                 990         


Gln Thr Tyr Arg Leu Glu Arg Ala  Arg Val Ser Arg Ala  Phe Cys Thr 
        995                 1000                 1005             


Gly Ile  Lys Pro Val Tyr Arg  Leu Thr Thr Arg Leu  Gly Arg Ser 
    1010                 1015                 1020             


Ile Arg  Ala Thr Ala Asn His  Arg Phe Leu Thr Pro  Gln Gly Trp 
    1025                 1030                 1035             


Lys Arg  Val Asp Glu Leu Gln  Pro Gly Asp Tyr Leu  Ala Leu Pro 
    1040                 1045                 1050             


Arg Arg  Ile Pro Thr Ala Ser  
    1055                 1060 


<210>  12
<211>  1224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminus fragment of Split 945

<400>  12

Met Ala Ala Ala Cys Pro Glu Leu Arg Gln Leu Ala Gln Ser Asp Val 
1               5                   10                  15      


Tyr Trp Asp Pro Ile Val Ser Ile Glu Pro Asp Gly Val Glu Glu Val 
            20                  25                  30          


Phe Asp Leu Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile 
        35                  40                  45              


Ile Ala His Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
    50                  55                  60                  


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
65                  70                  75                  80  


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
                85                  90                  95      


His Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys Lys 
            100                 105                 110         


Tyr Pro Lys Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr Lys Val Tyr 
        115                 120                 125             


Asp Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu Ile Gly Lys Ala 
    130                 135                 140                 


Thr Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr 
145                 150                 155                 160 


Glu Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Arg Pro Leu Ile Glu 
                165                 170                 175     


Thr Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe 
            180                 185                 190         


Ala Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys 
        195                 200                 205             


Lys Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro 
    210                 215                 220                 


Lys Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro 
225                 230                 235                 240 


Lys Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu 
                245                 250                 255     


Val Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val 
            260                 265                 270         


Lys Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys 
        275                 280                 285             


Asn Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys 
    290                 295                 300                 


Asp Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn 
305                 310                 315                 320 


Gly Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn 
                325                 330                 335     


Glu Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser 
            340                 345                 350         


His Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln 
        355                 360                 365             


Leu Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln 
    370                 375                 380                 


Ile Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp 
385                 390                 395                 400 


Lys Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu 
                405                 410                 415     


Gln Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala 
            420                 425                 430         


Pro Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr 
        435                 440                 445             


Thr Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile 
    450                 455                 460                 


Thr Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp 
465                 470                 475                 480 


Pro Ile Ala Gly Ser Lys Ala Ser Pro Lys Lys Lys Arg Lys Val Gly 
                485                 490                 495     


Arg Ala Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            500                 505                 510         


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Thr Leu 
        515                 520                 525             


Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu Pro Asp 
    530                 535                 540                 


Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala Trp Ala 
545                 550                 555                 560 


Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu Ile Ile 
                565                 570                 575     


Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr Pro Met 
            580                 585                 590         


Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg Leu Leu 
        595                 600                 605             


Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr Pro Leu 
    610                 615                 620                 


Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val Gln Asp 
625                 630                 635                 640 


Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr Val Pro 
                645                 650                 655     


Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln Trp Tyr 
            660                 665                 670         


Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu His Pro 
        675                 680                 685             


Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu Met Gly 
    690                 695                 700                 


Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe Lys Asn 
705                 710                 715                 720 


Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala Asp Phe 
                725                 730                 735     


Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp Asp Leu 
            740                 745                 750         


Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr Arg Ala 
        755                 760                 765             


Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala Lys Lys 
    770                 775                 780                 


Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu Leu Lys 
785                 790                 795                 800 


Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val Met Gly 
                805                 810                 815     


Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu Gly Lys 
            820                 825                 830         


Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met Ala Ala 
        835                 840                 845             


Pro Leu Tyr Pro Leu Thr Lys Pro Gly Thr Leu Phe Asn Trp Gly Pro 
    850                 855                 860                 


Asp Gln Gln Lys Ala Tyr Gln Glu Ile Lys Gln Ala Leu Leu Thr Ala 
865                 870                 875                 880 


Pro Ala Leu Gly Leu Pro Asp Leu Thr Lys Pro Phe Glu Leu Phe Val 
                885                 890                 895     


Asp Glu Lys Gln Gly Tyr Ala Lys Gly Val Leu Thr Gln Lys Leu Gly 
            900                 905                 910         


Pro Trp Arg Arg Pro Val Ala Tyr Leu Ser Lys Lys Leu Asp Pro Val 
        915                 920                 925             


Ala Ala Gly Trp Pro Pro Cys Leu Arg Met Val Ala Ala Ile Ala Val 
    930                 935                 940                 


Leu Thr Lys Asp Ala Gly Lys Leu Thr Met Gly Gln Pro Leu Val Ile 
945                 950                 955                 960 


Leu Ala Pro His Ala Val Glu Ala Leu Val Lys Gln Pro Pro Asp Arg 
                965                 970                 975     


Trp Leu Ser Asn Ala Arg Met Thr His Tyr Gln Ala Leu Leu Leu Asp 
            980                 985                 990         


Thr Asp Arg Val Gln Phe Gly Pro  Val Val Ala Leu Asn  Pro Ala Thr 
        995                 1000                 1005             


Leu Leu  Pro Leu Pro Glu Glu  Gly Leu Gln His Asn  Cys Leu Asp 
    1010                 1015                 1020             


Ile Leu  Ala Glu Ala His Gly  Thr Arg Pro Asp Leu  Thr Asp Gln 
    1025                 1030                 1035             


Pro Leu  Pro Asp Ala Asp His  Thr Trp Tyr Thr Asp  Gly Ser Ser 
    1040                 1045                 1050             


Leu Leu  Gln Glu Gly Gln Arg  Lys Ala Gly Ala Ala  Val Thr Thr 
    1055                 1060                 1065             


Glu Thr  Glu Val Ile Trp Ala  Lys Ala Leu Pro Ala  Gly Thr Ser 
    1070                 1075                 1080             


Ala Gln  Arg Ala Glu Leu Ile  Ala Leu Thr Gln Ala  Leu Lys Met 
    1085                 1090                 1095             


Ala Glu  Gly Lys Lys Leu Asn  Val Tyr Thr Asp Ser  Arg Tyr Ala 
    1100                 1105                 1110             


Phe Ala  Thr Ala His Ile His  Gly Glu Ile Tyr Arg  Arg Arg Gly 
    1115                 1120                 1125             


Trp Leu  Thr Ser Glu Gly Lys  Glu Ile Lys Asn Lys  Asp Glu Ile 
    1130                 1135                 1140             


Leu Ala  Leu Leu Lys Ala Leu  Phe Leu Pro Lys Arg  Leu Ser Ile 
    1145                 1150                 1155             


Ile His  Cys Pro Gly His Gln  Lys Gly His Ser Ala  Glu Ala Arg 
    1160                 1165                 1170             


Gly Asn  Arg Met Ala Asp Gln  Ala Ala Arg Lys Ala  Ala Ile Thr 
    1175                 1180                 1185             


Glu Thr  Pro Asp Thr Ser Thr  Leu Leu Ile Glu Asn  Ser Ser Pro 
    1190                 1195                 1200             


Ser Gly  Gly Ser Lys Arg Thr  Ala Asp Gly Ser Glu  Phe Glu Pro 
    1205                 1210                 1215             


Lys Lys  Lys Arg Lys Val 
    1220                 


<210>  13
<211>  1192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminus fragment of Split 1054

<400>  13

Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Arg Gly Met Asp Lys Lys Tyr Ser Ile Gly Leu Ala Ile Gly Thr 
        35                  40                  45              


Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser 
    50                  55                  60                  


Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys 
65                  70                  75                  80  


Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala 
                85                  90                  95      


Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn 
            100                 105                 110         


Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val 
        115                 120                 125             


Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu 
    130                 135                 140                 


Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu 
145                 150                 155                 160 


Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys 
                165                 170                 175     


Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala 
            180                 185                 190         


Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp 
        195                 200                 205             


Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val 
    210                 215                 220                 


Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly 
225                 230                 235                 240 


Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg 
                245                 250                 255     


Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu 
            260                 265                 270         


Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys 
        275                 280                 285             


Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp 
    290                 295                 300                 


Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln 
305                 310                 315                 320 


Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu 
                325                 330                 335     


Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu 
            340                 345                 350         


Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr 
        355                 360                 365             


Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu 
    370                 375                 380                 


Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly 
385                 390                 395                 400 


Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu 
                405                 410                 415     


Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp 
            420                 425                 430         


Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln 
        435                 440                 445             


Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe 
    450                 455                 460                 


Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr 
465                 470                 475                 480 


Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg 
                485                 490                 495     


Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn 
            500                 505                 510         


Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu 
        515                 520                 525             


Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro 
    530                 535                 540                 


Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr 
545                 550                 555                 560 


Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser 
                565                 570                 575     


Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg 
            580                 585                 590         


Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu 
        595                 600                 605             


Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala 
    610                 615                 620                 


Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp 
625                 630                 635                 640 


Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu 
                645                 650                 655     


Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys 
            660                 665                 670         


Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg 
        675                 680                 685             


Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly 
    690                 695                 700                 


Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser 
705                 710                 715                 720 


Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser 
                725                 730                 735     


Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly 
            740                 745                 750         


Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile 
        755                 760                 765             


Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys 
    770                 775                 780                 


Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg 
785                 790                 795                 800 


Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met 
                805                 810                 815     


Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys 
            820                 825                 830         


Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu 
        835                 840                 845             


Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp 
    850                 855                 860                 


Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser 
865                 870                 875                 880 


Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp 
                885                 890                 895     


Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys 
            900                 905                 910         


Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr 
        915                 920                 925             


Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser 
    930                 935                 940                 


Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg 
945                 950                 955                 960 


Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr 
                965                 970                 975     


Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr 
            980                 985                 990         


Leu Lys Ser Lys Leu Val Ser Asp  Phe Arg Lys Asp Phe  Gln Phe Tyr 
        995                 1000                 1005             


Lys Val  Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
    1010                 1015                 1020             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1025                 1030                 1035             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1040                 1045                 1050             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1055                 1060                 1065             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1070                 1075                 1080             


Glu Ile  Thr Leu Ala Asn Gly  Cys Leu Ala Gly Asp  Thr Leu Ile 
    1085                 1090                 1095             


Thr Leu  Ala Asp Gly Arg Arg  Val Pro Ile Arg Glu  Leu Val Ser 
    1100                 1105                 1110             


Gln Gln  Asn Phe Ser Val Trp  Ala Leu Asn Pro Gln  Thr Tyr Arg 
    1115                 1120                 1125             


Leu Glu  Arg Ala Arg Val Ser  Arg Ala Phe Cys Thr  Gly Ile Lys 
    1130                 1135                 1140             


Pro Val  Tyr Arg Leu Thr Thr  Arg Leu Gly Arg Ser  Ile Arg Ala 
    1145                 1150                 1155             


Thr Ala  Asn His Arg Phe Leu  Thr Pro Gln Gly Trp  Lys Arg Val 
    1160                 1165                 1170             


Asp Glu  Leu Gln Pro Gly Asp  Tyr Leu Ala Leu Pro  Arg Arg Ile 
    1175                 1180                 1185             


Pro Thr  Ala Ser 
    1190         


<210>  14
<211>  1226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminus fragment of Split 1054

<400>  14

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Arg Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp 
                725                 730                 735     


Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
            740                 745                 750         


Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val 
        755                 760                 765             


Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys 
785                 790                 795                 800 


Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu 
                805                 810                 815     


His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr 
            820                 825                 830         


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 
        835                 840                 845             


Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe 
    850                 855                 860                 


Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 
865                 870                 875                 880 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys 
                885                 890                 895     


Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln 
            900                 905                 910         


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu 
        915                 920                 925             


Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys 
945                 950                 955                 960 


Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu 
                965                 970                 975     


Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys 
            980                 985                 990         


Val Arg Glu Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1025                 1030                 1035             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1040                 1045                 1050             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1055                 1060                 1065             


Thr Leu  Ala Asn Gly Ser Gly  Gly Ser Ser Gly Gly  Ser Ser Gly 
    1070                 1075                 1080             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Ser 
    1085                 1090                 1095             


Gly Gly  Ser Ser Gly Gly Ser  Ser Cys Leu Ser Tyr  Glu Thr Glu 
    1100                 1105                 1110             


Ile Leu  Thr Val Glu Tyr Gly  Leu Leu Pro Ile Gly  Lys Ile Val 
    1115                 1120                 1125             


Glu Lys  Arg Ile Glu Cys Thr  Val Tyr Ser Val Asp  Asn Asn Gly 
    1130                 1135                 1140             


Asn Ile  Tyr Thr Gln Pro Val  Ala Gln Trp His Asp  Arg Gly Glu 
    1145                 1150                 1155             


Gln Glu  Val Phe Glu Tyr Cys  Leu Glu Asp Gly Ser  Leu Ile Arg 
    1160                 1165                 1170             


Ala Thr  Lys Asp His Lys Phe  Met Thr Val Asp Gly  Gln Met Leu 
    1175                 1180                 1185             


Pro Ile  Asp Glu Ile Phe Glu  Arg Glu Leu Asp Leu  Met Arg Val 
    1190                 1195                 1200             


Asp Asn  Leu Pro Asn Ser Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1205                 1210                 1215             


Val Pro  Lys Lys Lys Arg Lys  Val 
    1220                 1225     


<210>  15
<211>  1251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15 N-terminus fragment of Split 1115

<400>  15

Met Lys Arg Thr Ala Asp Gly Ser Glu Phe Glu Ser Pro Arg Lys Lys 
1               5                   10                  15      


Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn 
            20                  25                  30          


Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys 
        35                  40                  45              


Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn 
    50                  55                  60                  


Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr 
65                  70                  75                  80  


Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg 
                85                  90                  95      


Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp 
            100                 105                 110         


Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp 
        115                 120                 125             


Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val 
    130                 135                 140                 


Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu 
145                 150                 155                 160 


Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu 
                165                 170                 175     


Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu 
            180                 185                 190         


Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln 
        195                 200                 205             


Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val 
    210                 215                 220                 


Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu 
225                 230                 235                 240 


Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe 
                245                 250                 255     


Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser 
            260                 265                 270         


Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr 
        275                 280                 285             


Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr 
    290                 295                 300                 


Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu 
305                 310                 315                 320 


Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser 
                325                 330                 335     


Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu 
            340                 345                 350         


Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile 
        355                 360                 365             


Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly 
    370                 375                 380                 


Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys 
385                 390                 395                 400 


Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu 
                405                 410                 415     


Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile 
            420                 425                 430         


His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr 
        435                 440                 445             


Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe 
    450                 455                 460                 


Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe 
465                 470                 475                 480 


Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe 
                485                 490                 495     


Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg 
            500                 505                 510         


Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys 
        515                 520                 525             


His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys 
    530                 535                 540                 


Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly 
545                 550                 555                 560 


Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys 
                565                 570                 575     


Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys 
            580                 585                 590         


Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser 
        595                 600                 605             


Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe 
    610                 615                 620                 


Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr 
625                 630                 635                 640 


Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr 
                645                 650                 655     


Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg 
            660                 665                 670         


Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile 
        675                 680                 685             


Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp 
    690                 695                 700                 


Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu 
705                 710                 715                 720 


Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp 
                725                 730                 735     


Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys 
            740                 745                 750         


Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val 
        755                 760                 765             


Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu 
    770                 775                 780                 


Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys 
785                 790                 795                 800 


Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu 
                805                 810                 815     


His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr 
            820                 825                 830         


Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile 
        835                 840                 845             


Asn Arg Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe 
    850                 855                 860                 


Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys 
865                 870                 875                 880 


Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys 
                885                 890                 895     


Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln 
            900                 905                 910         


Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu 
        915                 920                 925             


Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln 
    930                 935                 940                 


Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys 
945                 950                 955                 960 


Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu 
                965                 970                 975     


Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys 
            980                 985                 990         


Val Arg Glu Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
        995                 1000                 1005             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    1010                 1015                 1020             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    1025                 1030                 1035             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    1040                 1045                 1050             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    1055                 1060                 1065             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    1070                 1075                 1080             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    1085                 1090                 1095             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    1100                 1105                 1110             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    1115                 1120                 1125             


Leu Pro  Lys Arg Asn Ser Gly  Gly Gly Gly Ser Gly  Gly Gly Gly 
    1130                 1135                 1140             


Ser Gly  Gly Gly Gly Ser Cys  Leu Ala Gly Asp Thr  Leu Ile Thr 
    1145                 1150                 1155             


Leu Ala  Asp Gly Arg Arg Val  Pro Ile Arg Glu Leu  Val Ser Gln 
    1160                 1165                 1170             


Gln Asn  Phe Ser Val Trp Ala  Leu Asn Pro Gln Thr  Tyr Arg Leu 
    1175                 1180                 1185             


Glu Arg  Ala Arg Val Ser Arg  Ala Phe Cys Thr Gly  Ile Lys Pro 
    1190                 1195                 1200             


Val Tyr  Arg Leu Thr Thr Arg  Leu Gly Arg Ser Ile  Arg Ala Thr 
    1205                 1210                 1215             


Ala Asn  His Arg Phe Leu Thr  Pro Gln Gly Trp Lys  Arg Val Asp 
    1220                 1225                 1230             


Glu Leu  Gln Pro Gly Asp Tyr  Leu Ala Leu Pro Arg  Arg Ile Pro 
    1235                 1240                 1245             


Thr Ala  Ser 
    1250     


<210>  16
<211>  679
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminus fragment of Split 1115

<400>  16

Met Ala Ala Ala Cys Pro Glu Leu Arg Gln Leu Ala Gln Ser Asp Val 
1               5                   10                  15      


Tyr Trp Asp Pro Ile Val Ser Ile Glu Pro Asp Gly Val Glu Glu Val 
            20                  25                  30          


Phe Asp Leu Thr Val Pro Gly Pro His Asn Phe Val Ala Asn Asp Ile 
        35                  40                  45              


Ile Ala His Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    50                  55                  60                  


Gly Gly Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys 
65                  70                  75                  80  


Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val 
                85                  90                  95      


Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys 
            100                 105                 110         


Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn 
        115                 120                 125             


Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp 
    130                 135                 140                 


Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly 
145                 150                 155                 160 


Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu 
                165                 170                 175     


Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His 
            180                 185                 190         


Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu 
        195                 200                 205             


Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile 
    210                 215                 220                 


Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys 
225                 230                 235                 240 


Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln 
                245                 250                 255     


Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro 
            260                 265                 270         


Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr 
        275                 280                 285             


Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 
    290                 295                 300                 


Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Ser 
305                 310                 315                 320 


Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                325                 330                 335     


Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
            340                 345                 350         


Thr Leu Asn Ile Glu Asp Glu Tyr Arg Leu His Glu Thr Ser Lys Glu 
        355                 360                 365             


Pro Asp Val Ser Leu Gly Ser Thr Trp Leu Ser Asp Phe Pro Gln Ala 
    370                 375                 380                 


Trp Ala Glu Thr Gly Gly Met Gly Leu Ala Val Arg Gln Ala Pro Leu 
385                 390                 395                 400 


Ile Ile Pro Leu Lys Ala Thr Ser Thr Pro Val Ser Ile Lys Gln Tyr 
                405                 410                 415     


Pro Met Ser Gln Glu Ala Arg Leu Gly Ile Lys Pro His Ile Gln Arg 
            420                 425                 430         


Leu Leu Asp Gln Gly Ile Leu Val Pro Cys Gln Ser Pro Trp Asn Thr 
        435                 440                 445             


Pro Leu Leu Pro Val Lys Lys Pro Gly Thr Asn Asp Tyr Arg Pro Val 
    450                 455                 460                 


Gln Asp Leu Arg Glu Val Asn Lys Arg Val Glu Asp Ile His Pro Thr 
465                 470                 475                 480 


Val Pro Asn Pro Tyr Asn Leu Leu Ser Gly Leu Pro Pro Ser His Gln 
                485                 490                 495     


Trp Tyr Thr Val Leu Asp Leu Lys Asp Ala Phe Phe Cys Leu Arg Leu 
            500                 505                 510         


His Pro Thr Ser Gln Pro Leu Phe Ala Phe Glu Trp Arg Asp Pro Glu 
        515                 520                 525             


Met Gly Ile Ser Gly Gln Leu Thr Trp Thr Arg Leu Pro Gln Gly Phe 
    530                 535                 540                 


Lys Asn Ser Pro Thr Leu Phe Asn Glu Ala Leu His Arg Asp Leu Ala 
545                 550                 555                 560 


Asp Phe Arg Ile Gln His Pro Asp Leu Ile Leu Leu Gln Tyr Val Asp 
                565                 570                 575     


Asp Leu Leu Leu Ala Ala Thr Ser Glu Leu Asp Cys Gln Gln Gly Thr 
            580                 585                 590         


Arg Ala Leu Leu Gln Thr Leu Gly Asn Leu Gly Tyr Arg Ala Ser Ala 
        595                 600                 605             


Lys Lys Ala Gln Ile Cys Gln Lys Gln Val Lys Tyr Leu Gly Tyr Leu 
    610                 615                 620                 


Leu Lys Glu Gly Gln Arg Trp Leu Thr Glu Ala Arg Lys Glu Thr Val 
625                 630                 635                 640 


Met Gly Gln Pro Thr Pro Lys Thr Pro Arg Gln Leu Arg Glu Phe Leu 
                645                 650                 655     


Gly Lys Ala Gly Phe Cys Arg Leu Phe Ile Pro Gly Phe Ala Glu Met 
            660                 665                 670         


Ala Ala Pro Leu Tyr Pro Leu 
        675                 


<210>  17
<211>  175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pegRNA

<400>  17
cgatttcttg gctttatata tcttgtggaa aggacgaaac accggcaact acaagacccg       60

cgccggtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta tcaacttgaa      120

aaagtggcac cgagtcggtg ccctcgaact tcacctcggc gcgggtcttt ttttt           175


<210>  18
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBL pegRNA 1

<400>  18
cgatttcttg gctttatata tcttgtggaa aggacgaaac accggcaact acaagacccg       60

cgccggtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta tcaacttgaa      120

aaagtggcac cgagtcggtg ccctcgaact tcacctcggc gcgggtctgt tttagagcta      180

gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg      240

gtgctttttt t                                                           251


<210>  19
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBL pegRNA 2

<400>  19
cgatttcttg gctttatata tcttgtggaa aggacgaaac accggcaact acaagacccg       60

cgccggtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta tcaacttgaa      120

aaagtggcac cgagtcggtg ccctcgaact tcacctcggc gcgggtcttt tttagagcta      180

gaaatagcaa gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg      240

gtgctttttt t                                                           251


<210>  20
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBL pegRNA 3

<400>  20
cgatttcttg gctttatata tcttgtggaa aggacgaaac accggcaact acaagacccg       60

cgccggtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta tcaacttgaa      120

aaagtggcac cgagtcggtc ctcgaacttc acctcggcgc gggtctgttt tagagctaga      180

aatagcaagt taaaataagg ctagtccgtt atcaacttga aaaagtggca ccgagtcggt      240

gcttttttt                                                              249


<210>  21
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBL pegRNA 4

<400>  21
cgatttcttg gctttatata tcttgtggaa aggacgaaac accggcaact acaagacccg       60

cgccggtttt agagctagaa atagcaagtt aaaataaggc tagtccgtta tcaacttgaa      120

aaagtggcac cgagtcggtc ctcgaacttc acctcggcgc gggtcttttt tagagctaga      180

aatagcaagt taaaataagg ctagtccgtt atcaacttga aaaagtggca ccgagtcggt      240

gcttttttt                                                              249


<210>  22
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  22

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Thr 
        


<210>  23
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  23

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Thr Leu Glu Pro Gly Glu Lys Pro Tyr Lys Cys Pro Glu Cys Gly 
        35                  40                  45              


Lys Ser Phe Ser Gln Ser Gly Ala Leu Thr Arg His Gln Arg Thr His 
    50                  55                  60                  


Thr Arg Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
65                  70                  75                  80  


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Leu Glu 
                85                  90                  95  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  24

Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu 
            20                  25                  


<210>  25
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  25

Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr 
1               5                   10                  15      


Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Thr 
        


<210>  26
<211>  65
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  26

Ala Ser Ala Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
1               5                   10                  15      


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        35                  40                  45              


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Thr Leu 
    50                  55                  60                  


Glu 
65  


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  monopartite NLS from the SV40 Large T-antigen

<400>  27

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NLS of nucleoplasmin, KR[PAATKKAGQA]KKKK is an example of 
       bipartite signal

<400>  28

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  No prime editor

<400>  29
gccgaggtgt agttcgaggg c                                                 21


<210>  30
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  No prime editor

<400>  30
cggctccaca tcaagctccc g                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Prime editor

<400>  31
gccgaggtga agttcgaggg c                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Prime editor

<400>  32
cggctccact tcaagctccc g                                                 21


<210>  33
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of PE2

<400>  33
aagggcctga gtccgagcag aagaagaagg gctcccatca catcaac                     47


<210>  34
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of PE2


<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  n is a, c, g, t or u

<400>  34
aagggcctga gtccgagcag aagaagaagn gctcccatca catcaac                     47


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stop codon removed fluorescent

<400>  35

Ala Glu Val Lys Phe Glu Gly 
1               5           


<210>  36
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of PE2

<400>  36
gagcagaaga agaagggctc cc                                                22


<210>  37
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of PE2 (N-Terminus MMLV)

<400>  37
cagaagaaga agggctccc                                                    19


<210>  38
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Portion of split N-Terminus MMLV PE2

<400>  38
gaagggcctg agtccgagca gaagaagaag ggctcccatc acatcaaccg gtggcg           56


<210>  39
<211>  175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pegRNA

<400>  39
gctaaagaac cgaaatatat agaacacctt tcctgctttg tggccgttga tgttctgggc       60

gcggccaaaa tctcgatctt tatcgttcaa ttttattccg atcaggcaat agttgaactt      120

tttcaccgtg gctcagccac gggagcttga agtggagccg cgcccagaaa aaaaa           175


<210>  40
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBL pegRNA 1

<400>  40
gctaaagaac cgaaatatat agaacacctt tcctgctttg tggccgttga tgttctgggc       60

gcggccaaaa tctcgatctt tatcgttcaa ttttattccg atcaggcaat agttgaactt      120

tttcaccgtg gctcagccac gggagcttga agtggagccg cgcccagaca aaatctcgat      180

ctttatcgtt caattttatt ccgatcaggc aatagttgaa ctttttcacc gtggctcagc      240

cacgaaaaaa a                                                           251


<210>  41
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBL pegRNA 2

<400>  41
gctaaagaac cgaaatatat agaacacctt tcctgctttg tggccgttga tgttctgggc       60

gcggccaaaa tctcgatctt tatcgttcaa ttttattccg atcaggcaat agttgaactt      120

tttcaccgtg gctcagccac gggagcttga agtggagccg cgcccagaaa aaatctcgat      180

ctttatcgtt caattttatt ccgatcaggc aatagttgaa ctttttcacc gtggctcagc      240

cacgaaaaaa a                                                           251


<210>  42
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBL pegRNA 3

<400>  42
gctaaagaac cgaaatatat agaacacctt tcctgctttg tggccgttga tgttctgggc       60

gcggccaaaa tctcgatctt tatcgttcaa ttttattccg atcaggcaat agttgaactt      120

tttcaccgtg gctcagccag gagcttgaag tggagccgcg cccagacaaa atctcgatct      180

ttatcgttca attttattcc gatcaggcaa tagttgaact ttttcaccgt ggctcagcca      240

cgaaaaaaa                                                              249


<210>  43
<211>  249
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DBL pegRNA 4

<400>  43
gctaaagaac cgaaatatat agaacacctt tcctgctttg tggccgttga tgttctgggc       60

gcggccaaaa tctcgatctt tatcgttcaa ttttattccg atcaggcaat agttgaactt      120

tttcaccgtg gctcagccag gagcttgaag tggagccgcg cccagaaaaa atctcgatct      180

ttatcgttca attttattcc gatcaggcaa tagttgaact ttttcaccgt ggctcagcca      240

cgaaaaaaa                                                              249


