                         SEQUENCE LISTING

<110>  Indi Molecular, Inc.
       Agnew, Heather Dawn
       Eliasen, Anders
       Lai, Bert Tsunyin
 
<120>  COMPOSITIONS, DELIVERY SYSTEMS, AND METHODS USEFUL IN TUMOR 
       THERAPY

<130>  INDI 111 PCT

<150>  63/109,186
<151>  2020-11-03

<150>  63/256,885
<151>  2021-10-18

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  257
<212>  PRT
<213>  Human FOLR1 protein

<400>  1

Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val 
1               5                   10                  15      


Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu 
            20                  25                  30          


Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly 
        35                  40                  45              


Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala 
    50                  55                  60                  


Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr 
65                  70                  75                  80  


Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys 
                85                  90                  95      


Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn 
            100                 105                 110         


Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg 
        115                 120                 125             


Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu 
    130                 135                 140                 


Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp 
145                 150                 155                 160 


Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln 
                165                 170                 175     


Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile 
            180                 185                 190         


Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg 
        195                 200                 205             


Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu 
    210                 215                 220                 


Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala 
225                 230                 235                 240 


Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu 
                245                 250                 255     


Ser 
    


<210>  2
<211>  255
<212>  PRT
<213>  Mouse FOLR1 protein

<400>  2

Met Ala His Leu Met Thr Val Gln Leu Leu Leu Leu Val Met Trp Met 
1               5                   10                  15      


Ala Glu Cys Ala Gln Ser Arg Ala Thr Arg Ala Arg Thr Glu Leu Leu 
            20                  25                  30          


Asn Val Cys Met Asp Ala Lys His His Lys Glu Lys Pro Gly Pro Glu 
        35                  40                  45              


Asp Asn Leu His Asp Gln Cys Ser Pro Trp Lys Thr Asn Ser Cys Cys 
    50                  55                  60                  


Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Ile Ser Tyr Leu Tyr 
65                  70                  75                  80  


Arg Phe Asn Trp Asn His Cys Gly Thr Met Thr Ser Glu Cys Lys Arg 
                85                  90                  95      


His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn Leu Gly 
            100                 105                 110         


Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Ile Leu 
        115                 120                 125             


Asp Val Pro Leu Cys Lys Glu Asp Cys Gln Gln Trp Trp Glu Asp Cys 
    130                 135                 140                 


Gln Ser Ser Phe Thr Cys Lys Ser Asn Trp His Lys Gly Trp Asn Trp 
145                 150                 155                 160 


Ser Ser Gly His Asn Glu Cys Pro Val Gly Ala Ser Cys His Pro Phe 
                165                 170                 175     


Thr Phe Tyr Phe Pro Thr Ser Ala Ala Leu Cys Glu Glu Ile Trp Ser 
            180                 185                 190         


His Ser Tyr Lys Leu Ser Asn Tyr Ser Arg Gly Ser Gly Arg Cys Ile 
        195                 200                 205             


Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu Val Ala 
    210                 215                 220                 


Arg Phe Tyr Ala Glu Ala Met Ser Gly Ala Gly Phe His Gly Thr Trp 
225                 230                 235                 240 


Pro Leu Leu Cys Ser Leu Ser Leu Val Leu Leu Trp Val Ile Ser 
                245                 250                 255 


<210>  3
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epitope 1

<400>  3

His His Lys Glu Lys Pro Gly Pro Glu Asp Lys Leu His Glu 
1               5                   10                  


<210>  4
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope 2

<400>  4

Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Val 
1               5                   10                  15      


Leu Asn 
        


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope 3

<400>  5

Arg Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu 
1               5                   10                  15      


Glu Val Ala Arg 
            20  


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(5)

<400>  6

His Ser His Thr Ala 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(5)

<400>  7

Ser Leu Tyr Tyr Lys 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (2)..(5)

<400>  8

Gly His Trp Glu Phe 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(5)

<400>  9

Lys Tyr Glu Glu Thr 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(5)

<400>  10

Leu Thr Asp Trp His 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(5)

<400>  11

His Glu Pro Phe Phe 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(1)

<220>
<221>  D-amino acid
<222>  (3)..(5)

<400>  12

Trp Gly Leu His Lys 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(4)

<400>  13

Trp Trp Pro Arg Gly 
1               5   


<210>  14
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(4)

<400>  14

Asn Asn Tyr Leu 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(4)

<400>  15

Thr Trp Ser Trp 
1               


<210>  16
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(5)

<400>  16

Tyr Phe Tyr Thr Trp 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(5)

<400>  17

Trp Lys His Glu Phe 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(2)

<220>
<221>  D-amino acid
<222>  (4)..(5)

<400>  18

Thr Tyr Gly Glu His 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(2)

<220>
<221>  D-amino acid
<222>  (4)..(5)

<400>  19

Ala Asn Gly Glu Leu 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide


<220>
<221>  D-amino acid
<222>  (1)..(5)

<400>  20

Asp Glu Arg Tyr Thr 
1               5   


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  21

Trp Trp Glu Gln Asp Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly 
1               5                   10                  15      


Thr Pro 
        


<210>  22
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  22

Trp Trp Glu Leu Asp Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly 
1               5                   10                  15      


Thr Pro 
        


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  23

Tyr Trp Trp Glu Arg Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly 
1               5                   10                  15      


Thr Pro 
        


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  24

Glu Trp Trp Trp Arg Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly 
1               5                   10                  15      


Thr Pro 
        


<210>  25
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  25

Leu Phe Trp Trp Glu Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly 
1               5                   10                  15      


Thr Pro 
        


<210>  26
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  26

Lys Trp Trp Glu Ile Arg Asp Trp Asp Phe Asp Val Phe Gly Gly Gly 
1               5                   10                  15      


Thr Pro Ala Lys Ser Asp Glu 
            20              


<210>  27
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  27

Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10      


<210>  28
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  28

Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu 
1               5                   10                  15      


Asp Asp 
        


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  29

Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Gly Asp 
1               5                   10                  15  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  30

Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Glu Asp Asp Glu 
            20  


<210>  31
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  31

Gln Gly Leu Ile Gly Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp 
1               5                   10                  15      


Gly Arg Ser Val 
            20  


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  32

Glu Tyr Glu Lys Glu Tyr Glu 
1               5           


<210>  33
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  33

Leu Ala Glu Ala Lys Val Leu Ala Asn Arg Glu Leu Asp Lys Tyr Gly 
1               5                   10                  15      


Val Ser Asp Tyr Tyr Lys Asn Leu Ile Asn Asn Ala Lys Thr Val Glu 
            20                  25                  30          


Gly Val Lys Ala Leu Ile Asp Glu Ile Leu Ala Ala 
        35                  40                  


<210>  34
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  34

Leu Lys Asn Ala Lys Glu Asp Ala Ile Ala Glu Leu Lys Lys Ala Gly 
1               5                   10                  15      


Ile Thr Ser Asp Phe Tyr Phe Asn Ala Ile Asn Lys Ala Lys Thr Val 
            20                  25                  30          


Glu Glu Val Asn Ala Leu Lys Asn Glu Ile Leu Lys Ala 
        35                  40                  45  


<210>  35
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  35

Leu Lys Glu Ala Lys Glu Lys Ala Ile Glu Glu Leu Lys Lys Ala Gly 
1               5                   10                  15      


Ile Thr Ser Asp Tyr Tyr Phe Asp Leu Ile Asn Lys Ala Lys Thr Val 
            20                  25                  30          


Glu Gly Val Asn Ala Leu Lys Asp Glu Ile Leu Lys Ala 
        35                  40                  45  


<210>  36
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  36

Thr Ile Asp Glu Trp Leu Leu Lys Glu Ala Lys Glu Lys Ala Ile Glu 
1               5                   10                  15      


Glu Leu Lys Lys Ala Gly Ile Thr Ser Asp Tyr Tyr Phe Asp Leu Ile 
            20                  25                  30          


Asn Lys Ala Lys Thr Val Glu Gly Val Asn Ala Leu Lys Asp Glu Ile 
        35                  40                  45              


Leu Lys Ala 
    50      


