                         SEQUENCE LISTING

<110>  EmendoBio Inc.
 
<120>  NOVEL OMNI-50 CRISPR NUCLEASE-RNA COMPLEXES

<130>  91628-A-PCT/GJG/AWG

<150>  63/109,835
<151>  2020-11-04

<160>  190   

<170>  PatentIn version 3.5

<210>  1
<211>  1370
<212>  PRT
<213>  Ezakiella peruensis strain M6.X2

<400>  1

Met Thr Lys Val Lys Asp Tyr Tyr Ile Gly Leu Asp Ile Gly Thr Ser 
1               5                   10                  15      


Ser Val Gly Trp Ala Val Thr Asp Glu Ala Tyr Asn Val Leu Lys Phe 
            20                  25                  30          


Asn Ser Lys Lys Met Trp Gly Val Arg Leu Phe Asp Asp Ala Lys Thr 
        35                  40                  45              


Ala Glu Glu Arg Arg Gly Gln Arg Gly Ala Arg Arg Arg Leu Asp Arg 
    50                  55                  60                  


Lys Lys Glu Arg Leu Ser Leu Leu Gln Asp Phe Phe Ala Glu Glu Val 
65                  70                  75                  80  


Ala Lys Val Asp Pro Asn Phe Phe Leu Arg Leu Asp Asn Ser Asp Leu 
                85                  90                  95      


Tyr Met Glu Asp Lys Asp Gln Lys Leu Lys Ser Lys Tyr Thr Leu Phe 
            100                 105                 110         


Asn Asp Lys Asp Phe Lys Asp Lys Asn Phe His Lys Lys Tyr Pro Thr 
        115                 120                 125             


Ile His His Leu Leu Met Asp Leu Ile Glu Asp Asp Ser Lys Lys Asp 
    130                 135                 140                 


Ile Arg Leu Val Tyr Leu Ala Cys His Tyr Leu Leu Lys Asn Arg Gly 
145                 150                 155                 160 


His Phe Ile Phe Glu Gly Gln Lys Phe Asp Thr Lys Ser Ser Phe Glu 
                165                 170                 175     


Asn Ser Leu Asn Glu Leu Lys Val His Leu Asn Asp Glu Tyr Gly Leu 
            180                 185                 190         


Asp Leu Glu Phe Asp Asn Glu Asn Leu Ile Asn Ile Leu Thr Asp Pro 
        195                 200                 205             


Lys Leu Asn Lys Thr Ala Lys Lys Lys Glu Leu Lys Ser Val Ile Gly 
    210                 215                 220                 


Asp Thr Lys Phe Leu Lys Ala Val Ser Ala Ile Met Ile Gly Ser Ser 
225                 230                 235                 240 


Gln Lys Leu Val Asp Leu Phe Glu Asn Pro Glu Asp Phe Asp Asp Ser 
                245                 250                 255     


Ala Ile Lys Ser Val Asp Phe Ser Thr Thr Ser Phe Asp Asp Lys Tyr 
            260                 265                 270         


Ser Asp Tyr Glu Leu Ala Leu Gly Asp Lys Ile Ala Leu Val Asn Ile 
        275                 280                 285             


Leu Lys Glu Ile Tyr Asp Ser Ser Ile Leu Glu Asn Leu Leu Lys Glu 
    290                 295                 300                 


Ala Asp Lys Ser Lys Asp Gly Asn Lys Tyr Ile Ser Asn Ala Phe Val 
305                 310                 315                 320 


Lys Lys Tyr Asn Lys His Gly Gln Asp Leu Lys Glu Phe Lys Arg Leu 
                325                 330                 335     


Val Arg Gln Tyr His Lys Ser Ala Tyr Phe Asp Ile Phe Arg Ser Glu 
            340                 345                 350         


Lys Val Asn Asp Asn Tyr Val Ser Tyr Thr Lys Ser Ser Ile Ser Asn 
        355                 360                 365             


Asn Lys Arg Val Lys Ala Asn Lys Phe Thr Asp Gln Glu Ala Phe Tyr 
    370                 375                 380                 


Lys Phe Ala Lys Lys His Leu Glu Thr Ile Lys Tyr Lys Ile Asn Lys 
385                 390                 395                 400 


Val Asn Gly Ser Lys Ala Asp Leu Glu Leu Ile Asp Gly Met Leu Arg 
                405                 410                 415     


Asp Met Glu Phe Lys Asn Phe Met Pro Lys Ile Lys Ser Ser Asp Asn 
            420                 425                 430         


Gly Val Ile Pro Tyr Gln Leu Lys Leu Met Glu Leu Asn Lys Ile Leu 
        435                 440                 445             


Glu Asn Gln Ser Lys His His Glu Phe Leu Asn Val Ser Asp Glu Tyr 
    450                 455                 460                 


Gly Ser Val Cys Asp Lys Ile Ala Ser Ile Met Glu Phe Arg Ile Pro 
465                 470                 475                 480 


Tyr Tyr Val Gly Pro Leu Asn Pro Asn Ser Lys Tyr Ala Trp Ile Lys 
                485                 490                 495     


Lys Gln Lys Asp Ser Glu Ile Thr Pro Trp Asn Phe Lys Asp Val Val 
            500                 505                 510         


Asp Leu Asp Ser Ser Arg Glu Glu Phe Ile Asp Ser Leu Ile Gly Arg 
        515                 520                 525             


Cys Thr Tyr Leu Lys Asp Glu Lys Val Leu Pro Lys Ala Ser Leu Leu 
    530                 535                 540                 


Tyr Asn Glu Tyr Met Val Leu Asn Glu Leu Asn Asn Leu Lys Leu Asn 
545                 550                 555                 560 


Asp Leu Pro Ile Thr Glu Glu Met Lys Lys Lys Ile Phe Asp Gln Leu 
                565                 570                 575     


Phe Lys Thr Arg Lys Lys Val Thr Leu Lys Ala Val Ala Asn Leu Leu 
            580                 585                 590         


Lys Lys Glu Phe Asn Ile Asn Gly Glu Ile Leu Leu Ser Gly Thr Asp 
        595                 600                 605             


Gly Asp Phe Lys Gln Gly Leu Asn Ser Tyr Asn Asp Phe Lys Ala Ile 
    610                 615                 620                 


Val Gly Asp Lys Val Asp Ser Asp Asp Tyr Arg Asp Lys Ile Glu Glu 
625                 630                 635                 640 


Ile Ile Lys Leu Ile Val Leu Tyr Gly Asp Asp Lys Ser Tyr Leu Gln 
                645                 650                 655     


Lys Lys Ile Lys Ala Gly Tyr Gly Lys Tyr Phe Thr Asp Ser Glu Ile 
            660                 665                 670         


Lys Lys Met Ala Gly Leu Asn Tyr Lys Asp Trp Gly Arg Leu Ser Lys 
        675                 680                 685             


Lys Leu Leu Thr Gly Leu Glu Gly Ala Asn Lys Ile Thr Gly Glu Arg 
    690                 695                 700                 


Gly Ser Ile Ile His Phe Met Arg Glu Tyr Asn Leu Asn Leu Met Glu 
705                 710                 715                 720 


Leu Met Ser Ala Ser Phe Thr Phe Thr Glu Glu Ile Gln Lys Leu Asn 
                725                 730                 735     


Pro Val Asp Asp Arg Lys Leu Ser Tyr Glu Met Val Asp Glu Leu Tyr 
            740                 745                 750         


Leu Ser Pro Ser Val Lys Arg Met Leu Trp Gln Ser Leu Arg Ile Val 
        755                 760                 765             


Asp Glu Ile Lys Asn Ile Met Gly Thr Asp Ser Lys Lys Ile Phe Ile 
    770                 775                 780                 


Glu Met Ala Arg Gly Lys Glu Glu Val Lys Ala Arg Lys Glu Ser Arg 
785                 790                 795                 800 


Lys Asn Gln Leu Leu Lys Phe Tyr Lys Asp Gly Lys Lys Ala Phe Ile 
                805                 810                 815     


Ser Glu Ile Gly Glu Glu Arg Tyr Ser Tyr Leu Leu Ser Glu Ile Glu 
            820                 825                 830         


Gly Glu Glu Glu Asn Lys Phe Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr 
        835                 840                 845             


Thr Gln Leu Gly Arg Cys Met Tyr Ser Leu Glu Pro Ile Asp Ile Ser 
    850                 855                 860                 


Glu Leu Ser Ser Lys Asn Ile Tyr Asp Gln Asp His Ile Tyr Pro Lys 
865                 870                 875                 880 


Ser Lys Ile Tyr Asp Asp Ser Ile Glu Asn Arg Val Leu Val Lys Lys 
                885                 890                 895     


Asp Leu Asn Ser Lys Lys Gly Asn Ser Tyr Pro Ile Pro Asp Glu Ile 
            900                 905                 910         


Leu Asn Lys Asn Cys Tyr Ala Tyr Trp Lys Ile Leu Tyr Asp Lys Gly 
        915                 920                 925             


Leu Ile Gly Gln Lys Lys Tyr Thr Arg Leu Thr Arg Arg Thr Gly Phe 
    930                 935                 940                 


Thr Asp Asp Glu Leu Val Gln Phe Ile Ser Arg Gln Ile Val Glu Thr 
945                 950                 955                 960 


Arg Gln Ala Thr Lys Glu Thr Ala Asn Leu Leu Lys Thr Ile Cys Lys 
                965                 970                 975     


Asn Ser Glu Ile Val Tyr Ser Lys Ala Glu Asn Ala Ser Arg Phe Arg 
            980                 985                 990         


Gln Glu Phe Asp Ile Val Lys Cys  Arg Ala Val Asn Asp  Leu His His 
        995                 1000                 1005             


Met His  Asp Ala Tyr Ile Asn  Ile Ile Val Gly Asn  Val Tyr Asn 
    1010                 1015                 1020             


Thr Lys  Phe Thr Lys Asp Pro  Met Asn Phe Val Lys  Lys Gln Glu 
    1025                 1030                 1035             


Lys Ala  Arg Ser Tyr Asn Leu  Glu Asn Met Phe Lys  Tyr Asp Val 
    1040                 1045                 1050             


Lys Arg  Gly Gly Tyr Thr Ala  Trp Ile Ala Asp Asp  Glu Lys Gly 
    1055                 1060                 1065             


Thr Val  Lys Asn Ala Ser Ile  Lys Arg Ile Arg Lys  Glu Leu Glu 
    1070                 1075                 1080             


Gly Thr  Asn Tyr Arg Phe Thr  Arg Met Asn Tyr Ile  Glu Ser Gly 
    1085                 1090                 1095             


Ala Leu  Phe Asn Ala Thr Leu  Gln Arg Lys Asn Lys  Gly Ser Arg 
    1100                 1105                 1110             


Pro Leu  Lys Asp Lys Gly Pro  Lys Ser Ser Ile Glu  Lys Tyr Gly 
    1115                 1120                 1125             


Gly Tyr  Thr Asn Ile Asn Lys  Ala Cys Phe Ala Val  Leu Asp Ile 
    1130                 1135                 1140             


Lys Ser  Lys Asn Lys Ile Glu  Arg Lys Leu Met Pro  Val Glu Arg 
    1145                 1150                 1155             


Glu Ile  Tyr Ala Lys Gln Lys  Asn Asp Lys Lys Leu  Ser Asp Glu 
    1160                 1165                 1170             


Ile Phe  Ser Lys Tyr Leu Lys  Asp Arg Phe Gly Ile  Glu Asp Tyr 
    1175                 1180                 1185             


Arg Val  Val Tyr Pro Val Val  Lys Met Arg Thr Leu  Leu Lys Ile 
    1190                 1195                 1200             


Asp Gly  Ser Tyr Tyr Phe Ile  Thr Gly Gly Ser Asp  Lys Thr Leu 
    1205                 1210                 1215             


Glu Leu  Arg Ser Ala Leu Gln  Leu Ile Leu Pro Lys  Lys Asn Glu 
    1220                 1225                 1230             


Trp Ala  Ile Lys Gln Ile Asp  Lys Ser Ser Glu Asn  Asp Tyr Leu 
    1235                 1240                 1245             


Thr Ile  Glu Arg Ile Gln Asp  Leu Thr Glu Glu Leu  Val Tyr Asn 
    1250                 1255                 1260             


Thr Phe  Asp Ile Ile Val Asn  Lys Phe Lys Thr Ser  Val Phe Lys 
    1265                 1270                 1275             


Lys Ser  Phe Leu Asn Leu Phe  Gln Asp Asp Lys Ile  Glu Asn Ile 
    1280                 1285                 1290             


Asp Phe  Lys Phe Lys Ser Met  Asp Phe Lys Glu Lys  Cys Lys Thr 
    1295                 1300                 1305             


Leu Leu  Met Leu Val Lys Ala  Ile Arg Ala Ser Gly  Val Arg Gln 
    1310                 1315                 1320             


Asp Leu  Lys Ser Ile Asp Leu  Lys Ser Asp Tyr Gly  Arg Leu Ser 
    1325                 1330                 1335             


Ser Lys  Thr Asn Asn Ile Gly  Asn Tyr Gln Glu Phe  Lys Ile Ile 
    1340                 1345                 1350             


Asn Gln  Ser Ile Thr Gly Leu  Phe Glu Asn Glu Val  Asp Leu Leu 
    1355                 1360                 1365             


Lys Leu  
    1370 


<210>  2
<211>  4113
<212>  DNA
<213>  Ezakiella peruensis strain M6.X2

<400>  2
atgacaaaag taaaagatta ttatatcgga cttgatatag gtacatcatc agttggctgg       60

gcagtaacag acgaggctta caatgttcta aaattcaact ccaagaagat gtggggagtt      120

cgtctttttg atgatgccaa aactgctgaa gaaagacgag ggcaaagagg ggccaggaga      180

agacttgacc gcaaaaaaga acgcttaagt ctcttgcaag atttttttgc agaggaagtt      240

gctaaagtag atccaaattt ctttttgcgt ctagataaca gcgaccttta tatggaggac      300

aaagatcaaa agttaaagtc caagtacact ttatttaatg ataaagattt taaagacaag      360

aacttccaca aaaaatatcc gactatccac catctcctta tggacttgat tgaagatgat      420

agcaaaaaag atattagact ggtttattta gcttgccatt acttacttaa aaatcgtggc      480

cactttattt ttgaaggaca aaaatttgat acaaagagct cctttgaaaa ttctctaaat      540

gaattaaagg tccacttaaa tgatgaatac ggtcttgatc ttgagtttga taatgaaaat      600

ttgataaata tacttacaga tcctaagtta aacaagaccg caaaaaagaa agaacttaaa      660

agtgttattg gagatacaaa atttctaaag gcagtatctg ctattatgat tggtagctct      720

caaaagctag tagatctatt tgaaaatcct gaagactttg atgattcggc aatcaaatca      780

gtggattttt ctacgacgag ttttgatgat aaatatagcg attacgagtt agcccttggg      840

gataaaattg cccttgtaaa tatattaaaa gaaatctatg actcatctat acttgaaaat      900

ttattaaaag aagccgataa atcaaaagat ggcaataagt acatttctaa cgcctttgta      960

aaaaaatata acaagcatgg ccaggacctc aaggaattta agcgcctagt tagacagtac     1020

cataaatcag cctacttcga catctttagg agtgaaaaag taaacgataa ctatgtttca     1080

tataccaagt caagtatatc caataacaag agagtgaagg cgaataagtt tacagaccaa     1140

gaagcttttt ataagtttgc taaaaagcac ctagaaacta taaaatacaa aattaataaa     1200

gttaatggta gcaaagctga ccttgaacta atagatggaa tgctaaggga tatggaattt     1260

aaaaatttca tgccaaagat aaaatcttct gataatggag ttatacctta tcaattgaaa     1320

cttatggagc taaataagat ccttgaaaac caatccaaac accatgaatt tttaaacgta     1380

tccgatgaat atggaagcgt ttgcgacaag attgcttcga ttatggaatt taggattcca     1440

tattatgttg ggcctttaaa tcctaactca aaatatgctt ggattaagaa gcaaaaggac     1500

agcgaaatca cgccatggaa ttttaaagat gtagttgatt tggattcttc aagggaagag     1560

tttatagata gcttaattgg caggtgcaca tatttaaaag atgaaaaagt tctaccaaag     1620

gcctcgcttc tctacaatga gtatatggtt ttaaatgaac tcaacaattt aaaattaaat     1680

gatcttccta ttactgaaga aatgaagaag aaaatcttcg atcaactctt taagaccagg     1740

aaaaaagtaa cattaaaggc tgtcgctaat cttctcaaaa aagaatttaa tataaatgga     1800

gaaatcctat tgtccggcac agatggggat tttaaacaag ggctaaactc ttataacgat     1860

tttaaggcca ttgttgggga caaggttgac agcgacgact atagggataa aatcgaagaa     1920

attatcaagc taatcgtcct ctatggagat gacaaatctt acttgcaaaa gaaaataaag     1980

gcgggatacg gcaagtattt tacagattca gaaatcaaaa agatggctgg cctaaattat     2040

aaagactggg gcagattaag taaaaaacta ctcacaggtt tagaaggcgc caataaaatt     2100

acaggcgaaa gaggatctat aatccatttt atgcgtgagt acaatttaaa cttaatggaa     2160

ttaatgagcg ccagcttcac ttttacagag gaaattcaaa agttaaatcc agttgacgat     2220

agaaaactct cctatgagat ggttgatgag ctttatttat caccttcagt taagagaatg     2280

ttatggcaaa gtctaagaat agttgatgaa attaaaaata taatgggcac tgattccaag     2340

aaaatcttta ttgaaatggc caggggcaaa gaagaagtca aggctagaaa agaatctaga     2400

aaaaatcagc tcttaaaatt ttacaaggat ggcaaaaaag cctttatatc agaaatcggc     2460

gaagaaagat atagctatct tttaagtgaa atcgaaggag aagaggaaaa caaattcaga     2520

tgggacaatc tttatctcta ctacacccag cttggcaggt gtatgtatag tcttgagcca     2580

attgatattt cagaactctc atcgaaaaac atctatgacc aagaccacat ttatccaaag     2640

tcaaaaatct atgatgattc aattgaaaac agagttttgg ttaagaaaga tttaaatagc     2700

aagaaaggca attcataccc aataccggat gagattttaa ataaaaattg ctatgcttat     2760

tggaaaattc tatatgacaa gggactaatt ggtcaaaaga aatataccag acttacacgt     2820

aggacaggat ttactgatga tgaacttgtc caatttatat ccaggcaaat agttgagacc     2880

aggcaggcta ccaaagaaac agcaaatctc ttaaaaacca tttgcaaaaa ttcagaaata     2940

gtttactcta aggcagaaaa tgctagcaga ttcagacagg aatttgatat agtaaaatgc     3000

cgtgcagtca atgacctcca ccacatgcat gacgcttata taaatataat cgttggcaat     3060

gtctacaata caaaatttac caaagacccc atgaactttg tcaaaaaaca agagaaagct     3120

agaagttata acttggaaaa catgtttaaa tatgacgtaa agcgcggggg ctatacagca     3180

tggatagcag acgatgaaaa aggcactgtt aaaaatgcta gcatcaagag aataagaaaa     3240

gaactagagg ggaccaacta cagatttact cgcatgaatt atatagaaag tggtgcacta     3300

tttaatgcta ccctgcaaag aaaaaacaaa ggaagtcgcc ctctaaaaga taaggggcct     3360

aagagctcaa tagaaaaata tggtggatat actaatataa acaaggcttg ctttgcagtg     3420

ttggatatta aatcaaaaaa taaaatagaa agaaaattaa tgccagttga aagagaaata     3480

tacgctaagc aaaagaatga taaaaaattg agtgatgaaa tatttagcaa atatttgaaa     3540

gatagattcg gaattgaaga ttatagagta gtatatcctg tagtaaagat gagaactttg     3600

ttaaaaatag atggatctta ttattttata actggtggaa gtgacaaaac attggaatta     3660

aggagtgcac ttcaattaat attaccaaag aaaaatgaat gggcaataaa gcaaattgat     3720

aaatccagtg agaatgatta cctaacaatt gaaaggatac aagatttaac ggaagaactt     3780

gtatacaata cgtttgatat aatagtgaat aaatttaaaa catctgtatt taaaaaatca     3840

tttttgaatt tattccaaga tgataaaatc gaaaatatag attttaaatt caaatcaatg     3900

gattttaaag aaaagtgtaa aactctattg atgctagtaa aagccatcag agcttctggt     3960

gtacgccaag acttaaaatc tatagattta aaatcagact atggtagatt gagctccaag     4020

actaataata taggaaacta tcaagaattt aaaatcataa accaatcaat tacaggcctc     4080

tttgaaaacg aagtggactt gttaaaatta tga                                  4113


<210>  3
<211>  4107
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human optimized OMNI-50 DNA sequence

<400>  3
accaaggtga aggactacta cataggcttg gacatcggca cctctagcgt cgggtgggcc       60

gtcaccgatg aagcctataa cgtgcttaag tttaatagca agaaaatgtg gggcgtgcgg      120

ctgttcgacg acgctaagac ggcagaggag cgtaggggcc agcgaggagc aagacgacgt      180

ctggatcgga agaaggagag actcagcctg ctgcaggact tcttcgccga agaggtagca      240

aaggtcgacc ccaacttctt cctcaggctg gacaattccg atctgtacat ggaagataag      300

gaccagaaac tgaaaagcaa atatacactg ttcaacgaca aggacttcaa ggataagaat      360

tttcataaga agtaccccac aatacatcac ctgctgatgg atctgatcga ggacgacagt      420

aagaaggaca tccggctcgt ctacctggcc tgtcactatt tgctcaagaa caggggtcat      480

ttcatcttcg agggccagaa gttcgacact aaatcaagct tcgagaacag tttgaacgag      540

ctcaaagttc atttgaacga cgagtatgga ctggacctcg aatttgacaa cgagaacctg      600

attaacatct tgactgaccc aaaactcaat aaaacggcca agaagaagga gctgaagtcc      660

gtaatcggcg acaccaagtt cctcaaagcc gtttccgcga taatgatcgg ctctagccag      720

aaactcgtcg acttgttcga gaaccccgag gatttcgacg actctgcgat aaagtccgtt      780

gacttctcaa ctacctcttt cgacgacaag tactctgact atgaactcgc tctgggtgac      840

aagatcgctc tggtcaacat ccttaaggaa atttacgata gctccatcct cgagaacctg      900

ctcaaagagg cagacaagtc taaggacggt aacaaatata tcagtaatgc attcgtgaag      960

aagtacaata aacacggaca agatctgaaa gagttcaaac gtctggtacg acaatatcac     1020

aagagtgcgt attttgatat tttcagatcc gagaaggtga atgacaatta cgtcagctac     1080

actaaaagct caattagcaa caataaacgc gtcaaagcaa acaagttcac tgatcaagag     1140

gccttctaca aattcgccaa gaaacatctg gagacaatca agtataagat caacaaggta     1200

aacggctcca aggcagatct ggagctgatt gacgggatgc tgcgggacat ggagttcaag     1260

aactttatgc ccaaaattaa gtccagtgac aacggggtga ttccatacca gctcaagctg     1320

atggaattga acaaaatact cgagaatcag tcaaagcatc acgagttcct caatgtcagc     1380

gacgagtacg gctccgtgtg tgataaaatc gcatctatca tggagttccg tatcccctac     1440

tacgtgggac ccctgaaccc caatagcaag tacgcctgga tcaagaagca gaaagatagt     1500

gagattactc cctggaactt caaggacgtc gtggaccttg actccagcag agaggagttc     1560

attgactcac tgatcggacg ctgtacttac cttaaggacg agaaggtcct tcccaaagct     1620

tctttgctgt ataacgaata catggtgctg aacgagctga ataacctgaa gttgaacgac     1680

cttcccatca ccgaggagat gaagaagaag atatttgacc agttgttcaa aacaagaaag     1740

aaggtcaccc ttaaagcggt ggcaaacctg ctgaagaagg agttcaacat caacggcgag     1800

attctgctct ctgggaccga cggtgacttc aagcagggct tgaactcata caatgacttc     1860

aaagctatcg tgggcgataa agtcgattcc gatgattacc gggacaagat tgaggagatc     1920

attaaactga tagttcttta cggtgacgat aagagttacc ttcagaagaa gattaaagct     1980

gggtatggaa aatacttcac cgacagtgag attaagaaaa tggcggggct gaactacaag     2040

gattggggaa ggctctcaaa gaagctgctg acgggactcg agggtgcaaa caagatcact     2100

ggagagcggg gctccattat tcacttcatg agggaatata accttaatct gatggagctt     2160

atgtcagctt catttacgtt caccgaagag atacagaaac ttaaccccgt ggatgaccgc     2220

aagctgtcat acgaaatggt ggacgaactg tacctttctc ccagtgtgaa acggatgctc     2280

tggcagtccc tgcgcatcgt cgacgagata aagaacatca tgggaaccga cagtaagaag     2340

attttcatcg agatggctcg gggtaaggaa gaggtgaaag cccgcaagga gtcaaggaag     2400

aaccaactgc tgaagttcta taaagacgga aagaaggcat tcatcagcga gattggcgag     2460

gagaggtact cttacttgct ttctgagata gagggtgagg aagagaataa gtttcgatgg     2520

gataacctgt acctttatta tactcaactg ggtcgctgca tgtactcttt ggaacctatc     2580

gacatatctg agctgtcttc aaagaatatt tacgatcagg atcatatcta ccccaaaagc     2640

aagatttacg acgacagtat cgagaatagg gtgctggtga agaaggacct taactccaag     2700

aagggtaaca gctatcctat cccagacgaa atcctgaaca agaactgtta cgcctactgg     2760

aagatcctgt acgataaagg tcttatcggg cagaagaagt acactcggct gacccggaga     2820

actggcttca cggacgacga gctcgttcag ttcatctcaa gacagatcgt ggaaactaga     2880

caagcaacaa aggagactgc taacctgctc aagacaatat gtaagaactc cgagatcgtg     2940

tattccaaag ccgagaacgc aagtcggttt aggcaagagt tcgacatcgt gaagtgtagg     3000

gcggtgaacg atcttcatca tatgcacgat gcctacatca acatcatagt ggggaacgtg     3060

tataacacca agttcacgaa ggaccctatg aatttcgtaa agaagcagga aaaggcgcgg     3120

agctacaatc tcgagaatat gttcaagtac gatgtgaaac gtggcggata caccgcttgg     3180

atcgccgatg acgagaaggg caccgtgaag aacgcgagta ttaaacgtat ccggaaggag     3240

ctggaaggca caaattatag gttcacaaga atgaactaca ttgagtctgg agcgcttttc     3300

aacgccactc tccagcggaa gaataagggc tccagacccc tgaaggacaa aggcccgaaa     3360

tcttccatcg agaagtacgg cggctacaca aacatcaata aagcctgttt cgctgttctt     3420

gacatcaagt ctaagaacaa gattgagagg aagctgatgc ccgtcgagcg tgagatctat     3480

gccaaacaga agaacgacaa gaagctgtcc gacgagattt tctcaaagta cctcaaggac     3540

cgatttggca tcgaggacta cagggttgtc tacccagtgg tgaaaatgcg cacactgctc     3600

aagatcgacg gcagctacta cttcatcaca ggcggttctg ataagaccct ggagttgcga     3660

tctgctctgc agctgattct ccctaagaag aacgagtggg cgatcaaaca gatcgacaag     3720

tcttccgaaa acgactatct gacgatcgag cgtatccagg acctgaccga ggagctggtg     3780

tataacactt tcgacatcat cgtcaacaag ttcaagacca gtgtcttcaa gaagtctttc     3840

cttaacttgt ttcaggacga caagattgag aacattgact tcaagtttaa gtccatggac     3900

ttcaaggaga aatgcaagac acttctcatg ctggtcaagg cgattcgggc atccggcgtg     3960

aggcaggatc tcaagtccat cgacctcaag tctgattacg gacggctcag ttcaaagacc     4020

aacaacatcg gcaattacca ggagttcaag attattaatc agtccatcac tggactgttc     4080

gagaatgagg tcgatctcct gaagctg                                         4107


<210>  4
<211>  106
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA V1 scaffold

<400>  4
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaugcuugc uauugcaagc uuuuuu                     106


<210>  5
<211>  112
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  sgRNA V2 scaffold

<400>  5
guuugagagu uauguaagaa auuacaugac gaguucaaau aaaaauuuau ucaaaccgcc       60

uauuuauagg ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu              112


<210>  6
<211>  1410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pET9a OMNI50-HisTag Coding ORF Protein Sequence

<400>  6

Met Pro Lys Lys Lys Arg Lys Val Gly Thr Thr Lys Val Lys Asp Tyr 
1               5                   10                  15      


Tyr Ile Gly Leu Asp Ile Gly Thr Ser Ser Val Gly Trp Ala Val Thr 
            20                  25                  30          


Asp Glu Ala Tyr Asn Val Leu Lys Phe Asn Ser Lys Lys Met Trp Gly 
        35                  40                  45              


Val Arg Leu Phe Asp Asp Ala Lys Thr Ala Glu Glu Arg Arg Gly Gln 
    50                  55                  60                  


Arg Gly Ala Arg Arg Arg Leu Asp Arg Lys Lys Glu Arg Leu Ser Leu 
65                  70                  75                  80  


Leu Gln Asp Phe Phe Ala Glu Glu Val Ala Lys Val Asp Pro Asn Phe 
                85                  90                  95      


Phe Leu Arg Leu Asp Asn Ser Asp Leu Tyr Met Glu Asp Lys Asp Gln 
            100                 105                 110         


Lys Leu Lys Ser Lys Tyr Thr Leu Phe Asn Asp Lys Asp Phe Lys Asp 
        115                 120                 125             


Lys Asn Phe His Lys Lys Tyr Pro Thr Ile His His Leu Leu Met Asp 
    130                 135                 140                 


Leu Ile Glu Asp Asp Ser Lys Lys Asp Ile Arg Leu Val Tyr Leu Ala 
145                 150                 155                 160 


Cys His Tyr Leu Leu Lys Asn Arg Gly His Phe Ile Phe Glu Gly Gln 
                165                 170                 175     


Lys Phe Asp Thr Lys Ser Ser Phe Glu Asn Ser Leu Asn Glu Leu Lys 
            180                 185                 190         


Val His Leu Asn Asp Glu Tyr Gly Leu Asp Leu Glu Phe Asp Asn Glu 
        195                 200                 205             


Asn Leu Ile Asn Ile Leu Thr Asp Pro Lys Leu Asn Lys Thr Ala Lys 
    210                 215                 220                 


Lys Lys Glu Leu Lys Ser Val Ile Gly Asp Thr Lys Phe Leu Lys Ala 
225                 230                 235                 240 


Val Ser Ala Ile Met Ile Gly Ser Ser Gln Lys Leu Val Asp Leu Phe 
                245                 250                 255     


Glu Asn Pro Glu Asp Phe Asp Asp Ser Ala Ile Lys Ser Val Asp Phe 
            260                 265                 270         


Ser Thr Thr Ser Phe Asp Asp Lys Tyr Ser Asp Tyr Glu Leu Ala Leu 
        275                 280                 285             


Gly Asp Lys Ile Ala Leu Val Asn Ile Leu Lys Glu Ile Tyr Asp Ser 
    290                 295                 300                 


Ser Ile Leu Glu Asn Leu Leu Lys Glu Ala Asp Lys Ser Lys Asp Gly 
305                 310                 315                 320 


Asn Lys Tyr Ile Ser Asn Ala Phe Val Lys Lys Tyr Asn Lys His Gly 
                325                 330                 335     


Gln Asp Leu Lys Glu Phe Lys Arg Leu Val Arg Gln Tyr His Lys Ser 
            340                 345                 350         


Ala Tyr Phe Asp Ile Phe Arg Ser Glu Lys Val Asn Asp Asn Tyr Val 
        355                 360                 365             


Ser Tyr Thr Lys Ser Ser Ile Ser Asn Asn Lys Arg Val Lys Ala Asn 
    370                 375                 380                 


Lys Phe Thr Asp Gln Glu Ala Phe Tyr Lys Phe Ala Lys Lys His Leu 
385                 390                 395                 400 


Glu Thr Ile Lys Tyr Lys Ile Asn Lys Val Asn Gly Ser Lys Ala Asp 
                405                 410                 415     


Leu Glu Leu Ile Asp Gly Met Leu Arg Asp Met Glu Phe Lys Asn Phe 
            420                 425                 430         


Met Pro Lys Ile Lys Ser Ser Asp Asn Gly Val Ile Pro Tyr Gln Leu 
        435                 440                 445             


Lys Leu Met Glu Leu Asn Lys Ile Leu Glu Asn Gln Ser Lys His His 
    450                 455                 460                 


Glu Phe Leu Asn Val Ser Asp Glu Tyr Gly Ser Val Cys Asp Lys Ile 
465                 470                 475                 480 


Ala Ser Ile Met Glu Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Asn 
                485                 490                 495     


Pro Asn Ser Lys Tyr Ala Trp Ile Lys Lys Gln Lys Asp Ser Glu Ile 
            500                 505                 510         


Thr Pro Trp Asn Phe Lys Asp Val Val Asp Leu Asp Ser Ser Arg Glu 
        515                 520                 525             


Glu Phe Ile Asp Ser Leu Ile Gly Arg Cys Thr Tyr Leu Lys Asp Glu 
    530                 535                 540                 


Lys Val Leu Pro Lys Ala Ser Leu Leu Tyr Asn Glu Tyr Met Val Leu 
545                 550                 555                 560 


Asn Glu Leu Asn Asn Leu Lys Leu Asn Asp Leu Pro Ile Thr Glu Glu 
                565                 570                 575     


Met Lys Lys Lys Ile Phe Asp Gln Leu Phe Lys Thr Arg Lys Lys Val 
            580                 585                 590         


Thr Leu Lys Ala Val Ala Asn Leu Leu Lys Lys Glu Phe Asn Ile Asn 
        595                 600                 605             


Gly Glu Ile Leu Leu Ser Gly Thr Asp Gly Asp Phe Lys Gln Gly Leu 
    610                 615                 620                 


Asn Ser Tyr Asn Asp Phe Lys Ala Ile Val Gly Asp Lys Val Asp Ser 
625                 630                 635                 640 


Asp Asp Tyr Arg Asp Lys Ile Glu Glu Ile Ile Lys Leu Ile Val Leu 
                645                 650                 655     


Tyr Gly Asp Asp Lys Ser Tyr Leu Gln Lys Lys Ile Lys Ala Gly Tyr 
            660                 665                 670         


Gly Lys Tyr Phe Thr Asp Ser Glu Ile Lys Lys Met Ala Gly Leu Asn 
        675                 680                 685             


Tyr Lys Asp Trp Gly Arg Leu Ser Lys Lys Leu Leu Thr Gly Leu Glu 
    690                 695                 700                 


Gly Ala Asn Lys Ile Thr Gly Glu Arg Gly Ser Ile Ile His Phe Met 
705                 710                 715                 720 


Arg Glu Tyr Asn Leu Asn Leu Met Glu Leu Met Ser Ala Ser Phe Thr 
                725                 730                 735     


Phe Thr Glu Glu Ile Gln Lys Leu Asn Pro Val Asp Asp Arg Lys Leu 
            740                 745                 750         


Ser Tyr Glu Met Val Asp Glu Leu Tyr Leu Ser Pro Ser Val Lys Arg 
        755                 760                 765             


Met Leu Trp Gln Ser Leu Arg Ile Val Asp Glu Ile Lys Asn Ile Met 
    770                 775                 780                 


Gly Thr Asp Ser Lys Lys Ile Phe Ile Glu Met Ala Arg Gly Lys Glu 
785                 790                 795                 800 


Glu Val Lys Ala Arg Lys Glu Ser Arg Lys Asn Gln Leu Leu Lys Phe 
                805                 810                 815     


Tyr Lys Asp Gly Lys Lys Ala Phe Ile Ser Glu Ile Gly Glu Glu Arg 
            820                 825                 830         


Tyr Ser Tyr Leu Leu Ser Glu Ile Glu Gly Glu Glu Glu Asn Lys Phe 
        835                 840                 845             


Arg Trp Asp Asn Leu Tyr Leu Tyr Tyr Thr Gln Leu Gly Arg Cys Met 
    850                 855                 860                 


Tyr Ser Leu Glu Pro Ile Asp Ile Ser Glu Leu Ser Ser Lys Asn Ile 
865                 870                 875                 880 


Tyr Asp Gln Asp His Ile Tyr Pro Lys Ser Lys Ile Tyr Asp Asp Ser 
                885                 890                 895     


Ile Glu Asn Arg Val Leu Val Lys Lys Asp Leu Asn Ser Lys Lys Gly 
            900                 905                 910         


Asn Ser Tyr Pro Ile Pro Asp Glu Ile Leu Asn Lys Asn Cys Tyr Ala 
        915                 920                 925             


Tyr Trp Lys Ile Leu Tyr Asp Lys Gly Leu Ile Gly Gln Lys Lys Tyr 
    930                 935                 940                 


Thr Arg Leu Thr Arg Arg Thr Gly Phe Thr Asp Asp Glu Leu Val Gln 
945                 950                 955                 960 


Phe Ile Ser Arg Gln Ile Val Glu Thr Arg Gln Ala Thr Lys Glu Thr 
                965                 970                 975     


Ala Asn Leu Leu Lys Thr Ile Cys Lys Asn Ser Glu Ile Val Tyr Ser 
            980                 985                 990         


Lys Ala Glu Asn Ala Ser Arg Phe  Arg Gln Glu Phe Asp  Ile Val Lys 
        995                 1000                 1005             


Cys Arg  Ala Val Asn Asp Leu  His His Met His Asp  Ala Tyr Ile 
    1010                 1015                 1020             


Asn Ile  Ile Val Gly Asn Val  Tyr Asn Thr Lys Phe  Thr Lys Asp 
    1025                 1030                 1035             


Pro Met  Asn Phe Val Lys Lys  Gln Glu Lys Ala Arg  Ser Tyr Asn 
    1040                 1045                 1050             


Leu Glu  Asn Met Phe Lys Tyr  Asp Val Lys Arg Gly  Gly Tyr Thr 
    1055                 1060                 1065             


Ala Trp  Ile Ala Asp Asp Glu  Lys Gly Thr Val Lys  Asn Ala Ser 
    1070                 1075                 1080             


Ile Lys  Arg Ile Arg Lys Glu  Leu Glu Gly Thr Asn  Tyr Arg Phe 
    1085                 1090                 1095             


Thr Arg  Met Asn Tyr Ile Glu  Ser Gly Ala Leu Phe  Asn Ala Thr 
    1100                 1105                 1110             


Leu Gln  Arg Lys Asn Lys Gly  Ser Arg Pro Leu Lys  Asp Lys Gly 
    1115                 1120                 1125             


Pro Lys  Ser Ser Ile Glu Lys  Tyr Gly Gly Tyr Thr  Asn Ile Asn 
    1130                 1135                 1140             


Lys Ala  Cys Phe Ala Val Leu  Asp Ile Lys Ser Lys  Asn Lys Ile 
    1145                 1150                 1155             


Glu Arg  Lys Leu Met Pro Val  Glu Arg Glu Ile Tyr  Ala Lys Gln 
    1160                 1165                 1170             


Lys Asn  Asp Lys Lys Leu Ser  Asp Glu Ile Phe Ser  Lys Tyr Leu 
    1175                 1180                 1185             


Lys Asp  Arg Phe Gly Ile Glu  Asp Tyr Arg Val Val  Tyr Pro Val 
    1190                 1195                 1200             


Val Lys  Met Arg Thr Leu Leu  Lys Ile Asp Gly Ser  Tyr Tyr Phe 
    1205                 1210                 1215             


Ile Thr  Gly Gly Ser Asp Lys  Thr Leu Glu Leu Arg  Ser Ala Leu 
    1220                 1225                 1230             


Gln Leu  Ile Leu Pro Lys Lys  Asn Glu Trp Ala Ile  Lys Gln Ile 
    1235                 1240                 1245             


Asp Lys  Ser Ser Glu Asn Asp  Tyr Leu Thr Ile Glu  Arg Ile Gln 
    1250                 1255                 1260             


Asp Leu  Thr Glu Glu Leu Val  Tyr Asn Thr Phe Asp  Ile Ile Val 
    1265                 1270                 1275             


Asn Lys  Phe Lys Thr Ser Val  Phe Lys Lys Ser Phe  Leu Asn Leu 
    1280                 1285                 1290             


Phe Gln  Asp Asp Lys Ile Glu  Asn Ile Asp Phe Lys  Phe Lys Ser 
    1295                 1300                 1305             


Met Asp  Phe Lys Glu Lys Cys  Lys Thr Leu Leu Met  Leu Val Lys 
    1310                 1315                 1320             


Ala Ile  Arg Ala Ser Gly Val  Arg Gln Asp Leu Lys  Ser Ile Asp 
    1325                 1330                 1335             


Leu Lys  Ser Asp Tyr Gly Arg  Leu Ser Ser Lys Thr  Asn Asn Ile 
    1340                 1345                 1350             


Gly Asn  Tyr Gln Glu Phe Lys  Ile Ile Asn Gln Ser  Ile Thr Gly 
    1355                 1360                 1365             


Leu Phe  Glu Asn Glu Val Asp  Leu Leu Lys Leu Gly  Ser Tyr Pro 
    1370                 1375                 1380             


Tyr Asp  Val Pro Asp Tyr Ala  Ala Ala Pro Lys Lys  Lys Arg Lys 
    1385                 1390                 1395             


Val Ala  Ala Ser His His His  His His His His His  
    1400                 1405                 1410 


<210>  7
<211>  6439
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pET9a OMNI50-HisTag DNA sequence

<400>  7
taatacgact cactataggg agaccacaac ggtttccctc tagagagaca ataaccctga       60

taatgcttca ataatattga aaaaggaaga gtatgcctaa gaagaagaga aaggtgggta      120

ccaccaaggt gaaggactac tacataggct tggacatcgg cacctctagc gtcgggtggg      180

ccgtcaccga tgaagcctat aacgtgctta agtttaatag caagaaaatg tggggcgtgc      240

ggctgttcga cgacgctaag acggcagagg agcgtagggg ccagcgagga gcaagacgac      300

gtctggatcg gaagaaggag agactcagcc tgctgcagga cttcttcgcc gaagaggtag      360

caaaggtcga ccccaacttc ttcctcaggc tggacaattc cgatctgtac atggaagata      420

aggaccagaa actgaaaagc aaatatacac tgttcaacga caaggacttc aaggataaga      480

attttcataa gaagtacccc acaatacatc acctgctgat ggatctgatc gaggacgaca      540

gtaagaagga catccggctc gtctacctgg cctgtcacta tttgctcaag aacaggggtc      600

atttcatctt cgagggccag aagttcgaca ctaaatcaag cttcgagaac agtttgaacg      660

agctcaaagt tcatttgaac gacgagtatg gactggacct cgaatttgac aacgagaacc      720

tgattaacat cttgactgac ccaaaactca ataaaacggc caagaagaag gagctgaagt      780

ccgtaatcgg cgacaccaag ttcctcaaag ccgtttccgc gataatgatc ggctctagcc      840

agaaactcgt cgacttgttc gagaaccccg aggatttcga cgactctgcg ataaagtccg      900

ttgacttctc aactacctct ttcgacgaca agtactctga ctatgaactc gctctgggtg      960

acaagatcgc tctggtcaac atccttaagg aaatttacga tagctccatc ctcgagaacc     1020

tgctcaaaga ggcagacaag tctaaggacg gtaacaaata tatcagtaat gcattcgtga     1080

agaagtacaa taaacacgga caagatctga aagagttcaa acgtctggta cgacaatatc     1140

acaagagtgc gtattttgat attttcagat ccgagaaggt gaatgacaat tacgtcagct     1200

acactaaaag ctcaattagc aacaataaac gcgtcaaagc aaacaagttc actgatcaag     1260

aggccttcta caaattcgcc aagaaacatc tggagacaat caagtataag atcaacaagg     1320

taaacggctc caaggcagat ctggagctga ttgacgggat gctgcgggac atggagttca     1380

agaactttat gcccaaaatt aagtccagtg acaacggggt gattccatac cagctcaagc     1440

tgatggaatt gaacaaaata ctcgagaatc agtcaaagca tcacgagttc ctcaatgtca     1500

gcgacgagta cggctccgtg tgtgataaaa tcgcatctat catggagttc cgtatcccct     1560

actacgtggg acccctgaac cccaatagca agtacgcctg gatcaagaag cagaaagata     1620

gtgagattac tccctggaac ttcaaggacg tcgtggacct cgactccagc agagaggagt     1680

tcattgactc actgatcgga cgctgtactt accttaagga cgagaaggtc cttcccaaag     1740

cttctttgct gtataacgaa tacatggtgc tgaacgagct gaataacctg aagttgaacg     1800

accttcccat caccgaggag atgaagaaga agatatttga ccagttgttc aaaacaagaa     1860

agaaggtcac ccttaaagcg gtggcaaacc tgctgaagaa ggagttcaac atcaacggcg     1920

agattctgct ctctgggacc gacggtgact tcaagcaggg cttgaactca tacaatgact     1980

tcaaagctat cgtgggcgat aaagtcgatt ccgatgatta ccgggacaag attgaggaga     2040

tcattaaact gatagttctt tacggtgacg ataagagtta ccttcagaag aagattaaag     2100

ctgggtatgg aaaatacttc accgacagtg agattaagaa aatggcgggg ctgaactaca     2160

aggattgggg aaggctctca aagaagctgc tgacgggact cgagggtgca aacaagatca     2220

ctggagagcg gggctccatt attcacttca tgagggaata taaccttaat ctgatggagc     2280

ttatgtcagc ttcatttacg ttcaccgaag agatacagaa acttaacccc gtggatgacc     2340

gcaagctgtc atacgaaatg gtggacgaac tgtacctttc tcccagtgtg aaacggatgc     2400

tctggcagtc cctgcgcatc gtcgacgaga taaagaacat catgggaacc gacagtaaga     2460

agattttcat cgagatggct cggggtaagg aagaggtgaa agcccgcaag gagtcaagga     2520

agaaccaact gctgaagttc tataaagacg gaaagaaggc attcatcagc gagattggcg     2580

aggagaggta ctcttacttg ctttctgaga tagagggtga ggaagagaat aagtttcgat     2640

gggataacct gtacctttat tatactcaac tgggtcgctg catgtactct ttggaaccta     2700

tcgacatatc tgagctgtct tcaaagaata tttacgatca ggatcatatc taccccaaaa     2760

gcaagattta cgacgacagt atcgagaata gggtgctggt gaagaaggac cttaactcca     2820

agaagggtaa cagctatcct atcccagacg aaatcctgaa caagaactgt tacgcctact     2880

ggaagatcct gtacgataaa ggtcttatcg ggcagaagaa gtacactcgg ctgacccgga     2940

gaactggctt cacggacgac gagctcgttc agttcatctc aagacagatc gtggaaacta     3000

gacaagcaac aaaggagact gctaacctgc tcaagacaat atgtaagaac tccgagatcg     3060

tgtattccaa agccgagaac gcaagtcggt ttaggcaaga gttcgacatc gtgaagtgta     3120

gggcggtgaa cgatcttcat catatgcacg atgcctacat caacatcata gtggggaacg     3180

tgtataacac caagttcacg aaggacccta tgaatttcgt aaagaagcag gaaaaggcgc     3240

ggagctacaa tctcgagaat atgttcaagt acgatgtgaa acgtggcgga tacaccgctt     3300

ggatcgccga tgacgagaag ggcaccgtga agaacgcgag tattaaacgt atccggaagg     3360

agctggaagg cacaaattat aggttcacaa gaatgaacta cattgagtct ggagcgcttt     3420

tcaacgccac tctccagcgg aagaataagg gctccagacc cctgaaggac aaaggcccga     3480

aatcttccat cgagaagtac ggcggctaca caaacatcaa taaagcctgt ttcgctgttc     3540

ttgacatcaa gtctaagaac aagattgaga ggaagctgat gcccgtcgag cgtgagatct     3600

atgccaaaca gaagaacgac aagaagctgt ccgacgagat tttctcaaag tacctcaagg     3660

accgatttgg catcgaggac tacagggttg tctacccagt ggtgaaaatg cgcacactgc     3720

tcaagatcga cggcagctac tacttcatca caggcggttc tgataagacc ctggagttgc     3780

gatctgctct gcagctgatt ctccctaaga agaacgagtg ggcgatcaaa cagatcgaca     3840

agtcttccga aaacgactat ctgacgatcg agcgtatcca ggacctgacc gaggagctgg     3900

tgtataacac tttcgacatc atcgtcaaca agttcaagac cagtgtcttc aagaagtctt     3960

tccttaactt gtttcaggac gacaagattg agaacattga cttcaagttt aagtccatgg     4020

acttcaagga gaaatgcaag acacttctca tgctggtcaa ggcgattcgg gcatccggcg     4080

tgaggcagga tctcaagtcc atcgacctca agtctgatta cggacggctc agttcaaaga     4140

ccaacaacat cggcaattac caggagttca agattattaa tcagtccatc actggactgt     4200

tcgagaatga ggtcgatctc ctgaagctgg gatcctaccc atacgatgtt ccagattacg     4260

cggccgctcc aaaaaagaaa agaaaagttg cggctagcca tcatcaccat caccatcatc     4320

attaaggctg ctaacaaagc ccgaaaggaa gctgagttgg ctgctgccac cgctgagcaa     4380

taactagcat aaccccttgg ggcctctaaa cgggtcttga ggggtttttt gctgaaagga     4440

ggaactatat ccggatatcc acaggacggg tgtggtcgcc atgatcgcgt agtcgatagt     4500

ggctccaagt agcgaagcga gcaggactgg gcggcggcca aagcggtcgg acagtgctcc     4560

gagaacgggt gcgcatagaa attgcatcaa cgcatatagc gctagcagca cgccatagtg     4620

actggcgatg ctgtcggaat ggacgatatc ccgcaagagg cccggcagta ccggcataac     4680

caagcctatg cctacagcat ccagggtgac ggtgccgagg atgacgatga gcgcattgtt     4740

agatttcata cacggtgcct gactgcgtta gcaatttaac tgtgataaac taccgcatta     4800

aagcttatcg atgataagct gtcaaacatg agaattctta gaaaaactca tcgagcatca     4860

aatgaaactg caatttattc atatcaggat tatcaatacc atatttttga aaaagccgtt     4920

tctgtaatga aggagaaaac tcaccgaggc agttccatag gatggcaaga tcctggtatc     4980

ggtctgcgat tccgactcgt ccaacatcaa tacaacctat taatttcccc tcgtcaaaaa     5040

taaggttatc aagtgagaaa tcaccatgag tgacgactga atccggtgag aatggcaaaa     5100

gcttatgcat ttctttccag acttgttcaa caggccagcc attacgctcg tcatcaaaat     5160

cactcgcatc aaccaaaccg ttattcattc gtgattgcgc ctgagcgaga cgaaatacgc     5220

gatcgctgtt aaaaggacaa ttacaaacag gaatcgaatg caaccggcgc aggaacactg     5280

ccagcgcatc aacaatattt tcacctgaat caggatattc ttctaatacc tggaatgctg     5340

ttttcccggg gatcgcagtg gtgagtaacc atgcatcatc aggagtacgg ataaaatgct     5400

tgatggtcgg aagaggcata aattccgtca gccagtttag tctgaccatc tcatctgtaa     5460

catcattggc aacgctacct ttgccatgtt tcagaaacaa ctctggcgca tcgggcttcc     5520

catacaatcg atagattgtc gcacctgatt gcccgacatt atcgcgagcc catttatacc     5580

catataaatc agcatccatg ttggaattta atcgcggcct cgagcaagac gtttcccgtt     5640

gaatatggct cataacaccc cttgtattac tgtttatgta agcagacagt tttattgttc     5700

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     5760

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     5820

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     5880

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     5940

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     6000

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     6060

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     6120

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     6180

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     6240

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     6300

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     6360

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     6420

atgttcgatc ccgcgaaat                                                  6439


<210>  8
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  8
guuugagagu uaug                                                         14


<210>  9
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  9
caugacgagu ucaaau                                                       16


<210>  10
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  10
aaaaauuuau ucaaacc                                                      17


<210>  11
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  11
aaaaauuuau uc                                                           12


<210>  12
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  12
gccuauuuau aggc                                                         14


<210>  13
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  13
cgcagauguu cugc                                                         14


<210>  14
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  14
auuaugcuug cuauugcaag cuuuuuu                                           27


<210>  15
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  15
auuaugcuug cuauu                                                        15


<210>  16
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  16
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaugcuugc uauu                                   94


<210>  17
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  17
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uu                                                82


<210>  18
<211>  70
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  18
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag                                                              70


<210>  19
<211>  58
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  19
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauu         58


<210>  20
<211>  46
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  20
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauuc                      46


<210>  21
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  21
guuugagagu uauggaaaca ugacgaguuc aaau                                   34


<210>  22
<211>  54
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  22
guuugagagu uauguaauuu cauauaggac uaaaacgaaa gcuauaauau guau             54


<210>  23
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  23
guuugagagu uauguaa                                                      17


<210>  24
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  24
guuugagagu uau                                                          13


<210>  25
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  25
guuugagagu ua                                                           12


<210>  26
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  26
uuacaugacg aguucaaau                                                    19


<210>  27
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  27
augacgaguu caaau                                                        15


<210>  28
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  28
ugacgaguuc aaau                                                         14


<210>  29
<211>  149
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  29
guuugagagu uauguaauuu cauauaggac uaaaacgaaa gcuauaauau guaugaaauu       60

acaugacgag uucaaauaaa aauuuauuca aaccgccuau uuauaggccg cagauguucu      120

gcauuaugcu ugcuauugca agcuuuuuu                                        149


<210>  30
<211>  104
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  30
guuugagagu uaugaaaaug acgaguucaa auaaaaauuu auucaaaccg ccuauuuaua       60

ggccgcagau guucugcauu augcuugcua uugcaagcuu uuuu                       104


<210>  31
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  31
guuugagagu uagaaaugac gaguucaaau aaaaauuuau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  32
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  32
gccuauaggc                                                              10


<210>  33
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  33
cgcagauguu cugu                                                         14


<210>  34
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  34
cgcagauguu cug                                                          13


<210>  35
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  35
agcuugcuau ugcaauuuu                                                    19


<210>  36
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  36
auuauuuuuu u                                                            11


<210>  37
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  37
auuaugcuuu ugcaauuuu                                                    19


<210>  38
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  38
auuuugcaag cuuuuuu                                                      17


<210>  39
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  39
cuauugcaag cuuuuuu                                                      17


<210>  40
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  40
caagcuuuuu u                                                            11


<210>  41
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  41
auuaugcuau ugcauuuuu                                                    19


<210>  42
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  42
uauugcaagc uuuuuu                                                       16


<210>  43
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  43
aaagcuuuuu u                                                            11


<210>  44
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  44
auuuugcuau ugcuuuuuu                                                    19


<210>  45
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  45
auugcaagcu uuuuu                                                        15


<210>  46
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  46
agcaagcuuu uuu                                                          13


<210>  47
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  47
auuaauugca agcuuuuuu                                                    19


<210>  48
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  48
auuaugcgca agcuuuuuu                                                    19


<210>  49
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  49
auagcuuuuu u                                                            11


<210>  50
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  50
auuacuauug caagcuuuuu u                                                 21


<210>  51
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  51
auuacaagcu uuuuu                                                        15


<210>  52
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  52
auugcuauug caagcuuuuu u                                                 21


<210>  53
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  53
ugcuugcuau agcuuuuuu                                                    19


<210>  54
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  54
uugcaagcuu uuuu                                                         14


<210>  55
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  55
aucuauugca agcuuuuuu                                                    19


<210>  56
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  56
aucuugcuau ugcaagcuuu uuu                                               23


<210>  57
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  57
aucaagcuuu uuu                                                          13


<210>  58
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  58
auuaugcucu uuuuu                                                        15


<210>  59
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  59
auauugcaag cuuuuuu                                                      17


<210>  60
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  60
auuaugcuuu uuu                                                          13


<210>  61
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  61
auuaugcuug cuauagcuuu u                                                 21


<210>  62
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  62
ugcuugcuau ugcaauuuu                                                    19


<210>  63
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  63
auuauaagcu uuuuu                                                        15


<210>  64
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  64
auuacuuuuu u                                                            11


<210>  65
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  65
auuaagcuuu uuu                                                          13


<210>  66
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  66
auuauuauug caagcuuuuu u                                                 21


<210>  67
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  67
auuuauugca agcuuuuuu                                                    19


<210>  68
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  68
ugcuugcuca agcuuuuuu                                                    19


<210>  69
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  69
auuuuuugca agcuuuuuu                                                    19


<210>  70
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  70
ugcuuuugca agcuuuuuu                                                    19


<210>  71
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  71
auuuugugca agcuuuuuu                                                    19


<210>  72
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  72
auuaugcuua agcuuuuuu                                                    19


<210>  73
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  73
ugcuauugca agcuuuuuu                                                    19


<210>  74
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  74
guuugagagu uaugaaaaug acgaguucaa auaaaaauuu auucaaaccg ccuauuuaua       60

ggccgcagau guucugcagc uugcuauugc aauuuu                                 96


<210>  75
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  75
guuugagagu uagaaaugac gaguucaaau aaaaauuuau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau uuuuuu                                            86


<210>  76
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  76
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaugcuuuu gcaauuuu                               98


<210>  77
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  77
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuuugcaagc uuuuuu                                 96


<210>  78
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  78
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugcc uauugcaagc uuuuuu                                 96


<210>  79
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  79
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugcc aagcuuuuuu                                        90


<210>  80
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  80
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaugcuauu gcauuuuu                               98


<210>  81
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  81
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcua uugcaagcuu uuuu                                              84


<210>  82
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  82
guuugagagu uagaaaugac gaguucaaau aaaaauuuau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau uu                                                82


<210>  83
<211>  79
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  83
guuugagagu uagaaaugac gaguucaaau aaaaauuuau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuu                                                    79


<210>  84
<211>  87
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  84
guuugagagu uaugaaauga cgaguucaaa uaaaaauuua uucaaaccgc cuauuuauag       60

gccgcagaug uucugcaaag cuuuuuu                                           87


<210>  85
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  85
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuuugcuauu gcuuuuuu                               98


<210>  86
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  86
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca gcuugcuauu gcaauuuu                               98


<210>  87
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  87
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugua uugcaagcuu uuuu                                   94


<210>  88
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  88
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca gcaagcuuuu uu                                     92


<210>  89
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  89
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaauugcaa gcuuuuuu                               98


<210>  90
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  90
guuugagagu uagaaaugac gaguucaaau aaaaauuuau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau gcgcaagcuu uuuu                                   94


<210>  91
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  91
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uagcuuuuuu                                        90


<210>  92
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  92
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuacuauugc aagcuuuuuu                            100


<210>  93
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  93
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuacaagcuu uuuu                                   94


<210>  94
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  94
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uugcuauugc aagcuuuuuu                            100


<210>  95
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  95
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuauuuuuuu                                        90


<210>  96
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  96
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugcu gcuugcuaua gcuuuuuu                               98


<210>  97
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  97
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucuguu gcaagcuuuu uu                                     92


<210>  98
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  98
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca ucuauugcaa gcuuuuuu                               98


<210>  99
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  99
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauagg       60

ccgcagaugu ucugcaucuu gcuauugcaa gcuuuuuu                               98


<210>  100
<211>  89
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  100
guuugagagu uaugaaauga cgaguucaaa uaaaaauuua uucaaaccgc cuauuuauag       60

gccgcagaug uucugcauca agcuuuuuu                                         89


<210>  101
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  101
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaugcucuu uuuu                                   94


<210>  102
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  102
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca ucaagcuuuu uu                                     92


<210>  103
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  103
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uauugcaagc uuuuuu                                 96


<210>  104
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  104
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca aagcuuuuuu                                        90


<210>  105
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  105
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaugcuuuu uu                                     92


<210>  106
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  106
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuau                                              84


<210>  107
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  107
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaugcuugc uauagcuuuu                            100


<210>  108
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  108
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugcu gcuugcuauu gcaauuuu                               98


<210>  109
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  109
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuauaagcuu uuuu                                   94


<210>  110
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  110
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuacuuuuuu                                        90


<210>  111
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  111
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuuuuuuu                                          88


<210>  112
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  112
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaagcuuuu uu                                     92


<210>  113
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  113
guuugagagu uagaaaugac gaguucaaau aaaaauuuau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauugc aagcuuuuuu                                        90


<210>  114
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  114
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuauuauugc aagcuuuuuu                            100


<210>  115
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  115
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuuauugcaa gcuuuuuu                               98


<210>  116
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  116
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugcu gcuugcucaa gcuuuuuu                               98


<210>  117
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  117
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuuuuugcaa gcuuuuuu                               98


<210>  118
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  118
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugcu gcuuuugcaa gcuuuuuu                               98


<210>  119
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  119
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuuugugcaa gcuuuuuu                               98


<210>  120
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  120
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag gcuauugcaa gcuuuuuu                                          88


<210>  121
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  121
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca gcuuuuuu                                          88


<210>  122
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  122
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugca uuaugcuuaa gcuuuuuu                               98


<210>  123
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  123
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucuguu uu                                                82


<210>  124
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  124
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugcu uuuu                                              84


<210>  125
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  125
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggccgcag auguucugcu gcuauugcaa gcuuuuuu                               98


<210>  126
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  126
guuugagagu uaugaaaaug acgaguucaa auaaaaauuu auucaaaccg ccuauuuaua       60

ggccgcagau guucugcuuu                                                   80


<210>  127
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  127
auuuauucaa acc                                                          13


<210>  128
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  128
aaauauucaa acc                                                          13


<210>  129
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  129
gauguucugc                                                              10


<210>  130
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  130
cgcguucugc                                                              10


<210>  131
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  131
ugcaagcuuu uuu                                                          13


<210>  132
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  132
guuugagagu uagaaaugac gaguucaaau aaaaauuuau ucaaaccgcc uauuuauagg       60

ccuauugcaa gcuuuuuu                                                     78


<210>  133
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  133
guuugagagu uaugaaaaug acgaguucaa auaaaaauuu auucaaaccg ccuauuuaua       60

ggccuucugc auuaugcuug cuauugcaag cuuuuuu                                97


<210>  134
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  134
guuugagagu uauguaagaa auuacaugac gaguucaaau aaaaauuuau ucaaaccgcc       60

uaugauguuc ugcauuaugc uugcuauugc aagcuuuuuu                            100


<210>  135
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  135
guuugagagu uagaaaugac gaguucaaau aaaaauuuau ucaaaccgcc uauuuauagg       60

ccgcaguugc aagcuuuuuu                                                   80


<210>  136
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  136
guuugagagu uagaaaugac gaguucaaau auuuauucaa accgccuauu uauaggccgc       60

agauguucug cugcaagcuu uuuu                                              84


<210>  137
<211>  98
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  137
guuugagagu uauggaaaca ugacgaguuc aaauaaauau ucaaaccgcc uauuuauagg       60

ccgcguucug cauuaugcuu gcuauugcaa gcuuuuuu                               98


<210>  138
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  138
ugacgaguuc aaaua                                                        15


<210>  139
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  139
aaaaauucaa acc                                                          13


<210>  140
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  140
aauuauucaa acc                                                          13


<210>  141
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  141
aaaaauuuaa acc                                                          13


<210>  142
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  142
aaaaauuuau ucc                                                          13


<210>  143
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  143
aaaaauuuau uca                                                          13


<210>  144
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  144
ccuauuuaua ggc                                                          13


<210>  145
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  145
cuauuuauag gc                                                           12


<210>  146
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  146
gccuauuuau agg                                                          13


<210>  147
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  147
agauguucug c                                                            11


<210>  148
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  148
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  149
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  149
guuugagagu uauggaaaca ugacgaguuc aaauaauuau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  150
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  150
guuugagagu uauggaaaca ugacgaguuc aaauauuuau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  151
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  151
guuugagagu uauggaaaca ugacgaguuc aaauaacgcc uauuuauagg ccgcagaugu       60

ucugcauuau gcuugcuauu gcaagcuuuu uu                                     92


<210>  152
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  152
guuugagagu uauggaaaca ugacgaguuc aaauaaauau ucaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  153
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  153
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau ggccgcagau guucugcauu       60

augcuugcua uugcaagcuu uuuu                                              84


<210>  154
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  154
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuaaaccgcc uauuuauagg       60

ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  155
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  155
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauuccgcc uauuuauagg       60

ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  156
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  156
guuugagagu uagaaaugac gaguucaaau aaaaggccgc agauguucug cauuaugcuu       60

gcuauugcaa gcuuuuuu                                                     78


<210>  157
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  157
guuugagagu uauggaaaca ugacgaguuc aaauaaccua uuuauaggcc gcagauguuc       60

ugcauuaugc uugcuauugc aagcuuuuuu                                        90


<210>  158
<211>  94
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  158
guuugagagu uauggaaaca ugacgaguuc aaauaaaacg ccuauuuaua ggccgcagau       60

guucugcauu augcuugcua uugcaagcuu uuuu                                   94


<210>  159
<211>  88
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  159
guuugagagu uauggaaaca ugacgaguuc aaauacuauu uauaggccgc agauguucug       60

cauuaugcuu gcuauugcaa gcuuuuuu                                          88


<210>  160
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  160
guuugagagu uauggaaaca ugacgaguuc aaauaauaua ggccgcagau guucugcauu       60

augcuugcua uugcaagcuu uuuu                                              84


<210>  161
<211>  82
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  161
guuugagagu uauggaaaca ugacgaguuc aaauaauagg ccgcagaugu ucugcauuau       60

gcuugcuauu gcaagcuuuu uu                                                82


<210>  162
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  162
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucagcc uauuuauagg       60

ccgcagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  163
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  163
guuugagagu uaugaaaaug acgaguucaa auaccgccua uuuauaggcc gcagauguuc       60

ugcauuaugc uugcuauugc aagcuuuuuu                                        90


<210>  164
<211>  96
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  164
guuugagagu uauggaaaca ugacgaguuc aaauacaaac cgccuauuua uaggccgcag       60

auguucugca uuaugcuugc uauugcaagc uuuuuu                                 96


<210>  165
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  165
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccuauuua       60

uaggagaugu ucugcauuau gcuugcuauu gcaagcuuuu uu                         102


<210>  166
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  166
guuugagagu uagaaaugac gaguucaaau aauaggccgc agauguucug cauuaugcuu       60

gcuauugcaa gcuuuuuu                                                     78


<210>  167
<211>  92
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-50 scaffold or scaffold portion

<400>  167
guuugagagu uauggaaaca ugacgaguuc aaauaaaaau uuauucaaac cgccugaugu       60

ucugcauuau gcuugcuauu gcaagcuuuu uu                                     92


<210>  168
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  168
gcagtccggg ctgggagcgg gt                                                22


<210>  169
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  169
cagctgcggg aaagggattc cc                                                22


<210>  170
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  170
cagctgcggg aatgggattc cc                                                22


<210>  171
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  171
gtgtcaagcc ccagaggcca ca                                                22


<210>  172
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  172
gtgtcaagcc ccagaggaca ca                                                22


<210>  173
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  173
cacagcgggt gtagactccg ag                                                22


<210>  174
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  174
cacagcaggt gtagactccg ag                                                22


<210>  175
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  175
gcagtccggg ctgggagcgg gtggg                                             25


<210>  176
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  176
cagctgcggg aaagggattc ccagg                                             25


<210>  177
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  177
cagctgcggg aatgggattc ccagg                                             25


<210>  178
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  178
gtgtcaagcc ccagaggcca caggg                                             25


<210>  179
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  179
gtgtcaagcc ccagaggaca caggg                                             25


<210>  180
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  180
cacagcgggt gtagactccg agggg                                             25


<210>  181
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  181
cacagcaggt gtagactccg agggg                                             25


<210>  182
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  182
gcagacaggg ccaggagcgg gaggg                                             25


<210>  183
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  183
gtggggcggg aaagggagtc ccagg                                             25


<210>  184
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  184
cagctgaggg aaaggaattc ccagg                                             25


<210>  185
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  185
aagccaaacc ccaaaggcca cacgg                                             25


<210>  186
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  186
aagacaagac ccagaggaca caggg                                             25


<210>  187
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  187
acagtcctgg ctgggagcag gtggg                                             25


<210>  188
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  188
cgcctgtggg aatgggcttc cccgg                                             25


<210>  189
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  189
tggccaagcc tcagaggcca caggg                                             25


<210>  190
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Spacer or target sequence

<400>  190
tcttcaagcc ccagaggaca ctggg                                             25


