                         SEQUENCE LISTING

<110>  Thomas Jefferson University
 
<120>  CHIMERIC AD5.F35-GUCY2C VACCINES AND VACCINATION

<130>  100051.19200

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  3787
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (118)..(3339)

<400>  1
tggagtgggc tgagggactc cactagaggc tgtccatctg gattccctgc ctccctagga       60

gcccaacaga gcaaagcaag tgggcacaag gagtatggtt ctaacgtgat tggggtc         117

atg aag acg ttg ctg ttg gac ttg gct ttg tgg tca ctg ctc ttc cag        165
Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln           
1               5                   10                  15                

ccc ggg tgg ctg tcc ttt agt tcc cag gtg agt cag aac tgc cac aat        213
Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn           
            20                  25                  30                    

ggc agc tat gaa atc agc gtc ctg atg atg ggc aac tca gcc ttt gca        261
Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala           
        35                  40                  45                        

gag ccc ctg aaa aac ttg gaa gat gcg gtg aat gag ggg ctg gaa ata        309
Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile           
    50                  55                  60                            

gtg aga gga cgt ctg caa aat gct ggc cta aat gtg act gtg aac gct        357
Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala           
65                  70                  75                  80            

act ttc atg tat tcg gat ggt ctg att cat aac tca ggc gac tgc cgg        405
Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg           
                85                  90                  95                

agt agc acc tgt gaa ggc ctc gac cta ctc agg aaa att tca aat gca        453
Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala           
            100                 105                 110                   

caa cgg atg ggc tgt gtc ctc ata ggg ccc tca tgt aca tac tcc acc        501
Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr           
        115                 120                 125                       

ttc cag atg tac ctt gac aca gaa ttg agc tac ccc atg atc tca gct        549
Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala           
    130                 135                 140                           

gga agt ttt gga ttg tca tgt gac tat aaa gaa acc tta acc agg ctg        597
Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu           
145                 150                 155                 160           

atg tct cca gct aga aag ttg atg tac ttc ttg gtt aac ttt tgg aaa        645
Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys           
                165                 170                 175               

acc aac gat ctg ccc ttc aaa act tat tcc tgg agc act tcg tat gtt        693
Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val           
            180                 185                 190                   

tac aag aat ggt aca gaa act gag gac tgt ttc tgg tac ctt aat gct        741
Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala           
        195                 200                 205                       

ctg gag gct agc gtt tcc tat ttc tcc cac gaa ctc ggc ttt aag gtg        789
Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val           
    210                 215                 220                           

gtg tta aga caa gat aag gag ttt cag gat atc tta atg gac cac aac        837
Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn           
225                 230                 235                 240           

agg aaa agc aat gtg att att atg tgt ggt ggt cca gag ttc ctc tac        885
Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr           
                245                 250                 255               

aag ctg aag ggt gac cga gca gtg gct gaa gac att gtc att att cta        933
Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu           
            260                 265                 270                   

gtg gat ctt ttc aat gac cag tac ttg gag gac aat gtc aca gcc cct        981
Val Asp Leu Phe Asn Asp Gln Tyr Leu Glu Asp Asn Val Thr Ala Pro           
        275                 280                 285                       

gac tat atg aaa aat gtc ctt gtt ctg acg ctg tct cct ggg aat tcc       1029
Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser           
    290                 295                 300                           

ctt cta aat agc tct ttc tcc agg aat cta tca cca aca aaa cga gac       1077
Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp           
305                 310                 315                 320           

ttt cgt ctt gcc tat ttg aat gga atc ctc gtc ttt gga cat atg ctg       1125
Phe Arg Leu Ala Tyr Leu Asn Gly Ile Leu Val Phe Gly His Met Leu           
                325                 330                 335               

aag ata ttt ctt gaa aat gga gaa aat att acc acc ccc aaa ttt gct       1173
Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala           
            340                 345                 350                   

cat gcc ttc agg aat ctc act ttt gaa ggg tat gac ggt cca gtg acc       1221
His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr           
        355                 360                 365                       

ttg gat gac tgg ggg gat gtt gac agt acc atg gtg ctt ctg tat acc       1269
Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr           
    370                 375                 380                           

tct gtg gac acc aag aaa tac aag gtt ctt ttg acc tat gat acc cac       1317
Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His           
385                 390                 395                 400           

gta aat aag acc tat cct gtg gat atg agc ccc aca ttc act tgg aag       1365
Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys           
                405                 410                 415               

aac tct aaa ctt cct aat gat att aca ggc cgg ggc cct cag atc ctg       1413
Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu           
            420                 425                 430                   

atg att gca gtc ttc acc ctc act gga gct gtg gtg ctg ctc ctg ctc       1461
Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu           
        435                 440                 445                       

gtc gct ctc ctg atg ctc aga aaa tat aga aaa gat tat gaa ctt cgt       1509
Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg           
    450                 455                 460                           

cag aaa aaa tgg tcc cac att cct cct gaa aat atc ttt cct ctg gag       1557
Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu           
465                 470                 475                 480           

acc aat gag acc aat cat gtt agc ctc aag atc gat gat gac aaa aga       1605
Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg           
                485                 490                 495               

cga gat aca atc cag aga cta cga cag tgc aaa tac gtc aaa aag cga       1653
Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Val Lys Lys Arg           
            500                 505                 510                   

gtg att ctc aaa gat ctc aag cac aat gat ggt aat ttc act gaa aaa       1701
Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys           
        515                 520                 525                       

cag aag ata gaa ttg aac aag ttg ctt cag att gac tat tac acc cta       1749
Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Thr Leu           
    530                 535                 540                           

acc aag ttc tac ggg aca gtg aaa ctg gat acc atg atc ttc ggg gtg       1797
Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val           
545                 550                 555                 560           

ata gaa tac tgt gag aga gga tcc ctc cgg gaa gtt tta aat gac aca       1845
Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr           
                565                 570                 575               

att tcc tac cct gat ggc aca ttc atg gat tgg gag ttt aag atc tct       1893
Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser           
            580                 585                 590                   

gtc ttg tat gac att gct aag gga atg tca tat ctg cac tcc agt aag       1941
Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys           
        595                 600                 605                       

aca gaa gtc cat ggt cgt ctg aaa tct acc aac tgc gta gtg gac agt       1989
Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser           
    610                 615                 620                           

aga atg gtg gtg aag atc act gat ttt ggc tgc aat tcc att ttg cct       2037
Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro           
625                 630                 635                 640           

cca aaa aag gac ctg tgg aca gct cca gag cac ctc cgc caa gcc aac       2085
Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn           
                645                 650                 655               

atc tct cag aaa gga gat gtg tac agc tat ggg atc atc gca cag gag       2133
Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu           
            660                 665                 670                   

atc att ctg cgg aaa gaa acc ttc tac act ttg agc tgt cgg gac cgg       2181
Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg           
        675                 680                 685                       

aat gag aag att ttc aga gtg gaa aat tcc aat gga atg aaa ccc ttc       2229
Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe           
    690                 695                 700                           

cgc cca gat tta ttc ttg gaa aca gca gag gaa aaa gag cta gaa gtg       2277
Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val           
705                 710                 715                 720           

tac cta ctt gta aaa aac tgt tgg gag gaa gat cca gaa aag aga cca       2325
Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro           
                725                 730                 735               

gat ttc aaa aaa att gag act aca ctt gcc aag ata ttt gga ctt ttt       2373
Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe           
            740                 745                 750                   

cat gac caa aaa aat gaa agc tat atg gat acc ttg atc cga cgt cta       2421
His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu           
        755                 760                 765                       

cag cta tat tct cga aac ctg gaa cat ctg gta gag gaa agg aca cag       2469
Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln           
    770                 775                 780                           

ctg tac aag gca gag agg gac agg gct gac aga ctt aac ttt atg ttg       2517
Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu           
785                 790                 795                 800           

ctt cca agg cta gtg gta aag tct ctg aag gag aaa ggc ttt gtg gag       2565
Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu           
                805                 810                 815               

ccg gaa cta tat gag gaa gtt aca atc tac ttc agt gac att gta ggt       2613
Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly           
            820                 825                 830                   

ttc act act atc tgc aaa tac agc acc ccc atg gaa gtg gtg gac atg       2661
Phe Thr Thr Ile Cys Lys Tyr Ser Thr Pro Met Glu Val Val Asp Met           
        835                 840                 845                       

ctt aat gac atc tat aag agt ttt gac cac att gtt gat cat cat gat       2709
Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp           
    850                 855                 860                           

gtc tac aag gtg gaa acc atc ggt gat gcg tac atg gtg gct agt ggt       2757
Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly           
865                 870                 875                 880           

ttg cct aag aga aat ggc aat cgg cat gca ata gac att gcc aag atg       2805
Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met           
                885                 890                 895               

gcc ttg gaa atc ctc agc ttc atg ggg acc ttt gag ctg gag cat ctt       2853
Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu           
            900                 905                 910                   

cct ggc ctc cca ata tgg att cgc att gga gtt cac tct ggt ccc tgt       2901
Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys           
        915                 920                 925                       

gct gct gga gtt gtg gga atc aag atg cct cgt tat tgt cta ttt gga       2949
Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly           
    930                 935                 940                           

gat acg gtc aac aca gcc tct agg atg gaa tcc act ggc ctc cct ttg       2997
Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu           
945                 950                 955                 960           

aga att cac gtg agt ggc tcc acc ata gcc atc ctg aag aga act gag       3045
Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu           
                965                 970                 975               

tgc cag ttc ctt tat gaa gtg aga gga gaa aca tac tta aag gga aga       3093
Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg           
            980                 985                 990                   

gga aat gag act acc tac tgg ctg  act ggg atg aag gac  cag aaa ttc     3141
Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe         
        995                 1000                 1005                     

aac ctg  cca acc cct cct act  gtg gag aat caa cag  cgt ttg caa        3186
Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln            
    1010                 1015                 1020                        

gca gaa  ttt tca gac atg att  gcc aac tct tta cag  aaa aga cag        3231
Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln            
    1025                 1030                 1035                        

gca gca  ggg ata aga agc caa  aaa ccc aga cgg gta  gcc agc tat        3276
Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr            
    1040                 1045                 1050                        

aaa aaa  ggc act ctg gaa tac  ttg cag ctg aat acc  aca gac aag        3321
Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys            
    1055                 1060                 1065                        

gag agc  acc tat ttt taa acctaaatga ggtataagga ctcacacaaa             3369
Glu Ser  Thr Tyr Phe                                                      
    1070                                                                  

ttaaaataca gctgcactga ggccaggcac cctcaggtgt cctgaaagct tactttcctg     3429

agacctcatg aggcagaaat gtcttaggct tggctgccct gtttggacca tggactttct     3489

ttgcatgaat cagatgtgtt ctcagtgaaa taactacctt ccactctgga accttattcc     3549

agcagttgtt ccagggagct tctacctgga aaagaaaaga atttcattta ttttttgttt     3609

gtttattttt atcgtttttg tttactggct ttccttctgt attcataaga ttttttaaat     3669

tgtcataatt atattttaaa tacccatctt cattaaagta tatttaactc ataatttttg     3729

cagaaaatat gctatatatt aggcaagaat aaaagctaaa ggtttcccaa aaaaaaaa       3787


<210>  2
<211>  1073
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Leu Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Arg Leu Ala Tyr Leu Asn Gly Ile Leu Val Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu 
            420                 425                 430         


Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu 
        435                 440                 445             


Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg 
    450                 455                 460                 


Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu 
465                 470                 475                 480 


Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg 
                485                 490                 495     


Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Val Lys Lys Arg 
            500                 505                 510         


Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys 
        515                 520                 525             


Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Thr Leu 
    530                 535                 540                 


Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val 
545                 550                 555                 560 


Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr 
                565                 570                 575     


Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser 
            580                 585                 590         


Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys 
        595                 600                 605             


Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser 
    610                 615                 620                 


Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro 
625                 630                 635                 640 


Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn 
                645                 650                 655     


Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu 
            660                 665                 670         


Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg 
        675                 680                 685             


Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe 
    690                 695                 700                 


Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val 
705                 710                 715                 720 


Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro 
                725                 730                 735     


Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe 
            740                 745                 750         


His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu 
        755                 760                 765             


Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln 
    770                 775                 780                 


Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu 
785                 790                 795                 800 


Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu 
                805                 810                 815     


Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
            820                 825                 830         


Phe Thr Thr Ile Cys Lys Tyr Ser Thr Pro Met Glu Val Val Asp Met 
        835                 840                 845             


Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp 
    850                 855                 860                 


Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly 
865                 870                 875                 880 


Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met 
                885                 890                 895     


Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu 
            900                 905                 910         


Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys 
        915                 920                 925             


Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly 
    930                 935                 940                 


Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu 
945                 950                 955                 960 


Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu 
                965                 970                 975     


Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg 
            980                 985                 990         


Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe 
        995                 1000                 1005             


Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln 
    1010                 1015                 1020             


Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln 
    1025                 1030                 1035             


Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr 
    1040                 1045                 1050             


Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys 
    1055                 1060                 1065             


Glu Ser  Thr Tyr Phe 
    1070             


<210>  3
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized DNA sequence of Human GUCY2C


<220>
<221>  CDS
<222>  (1)..(15)

<400>  3
atg aaa ggg ttt ccc                                                     15
Met Lys Gly Phe Pro                                                       
1               5                                                         


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Lys Gly Phe Pro 
1               5   


<210>  5
<211>  1287
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized DNA sequence of soluble human GUCY2C


<220>
<221>  CDS
<222>  (1)..(1287)

<400>  5
atg aaa aca ctg ctg ctg gat ctc gct ctg tgg tca ctc ctc ttt cag         48
Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln           
1               5                   10                  15                

ccc gga tgg ctg tca ttt tct tcc cag gtg tcc cag aat tgt cac aac         96
Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn           
            20                  25                  30                    

ggc tcc tac gaa atc tct gtc ctc atg atg ggc aat agc gcc ttt gcc        144
Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala           
        35                  40                  45                        

gaa cct ctc aaa aac ctc gag gat gct gtg aat gag gga ctg gag att        192
Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile           
    50                  55                  60                            

gtg agg gga cga ctc cag aac gct gga ctg aat gtc acc gtg aat gcc        240
Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala           
65                  70                  75                  80            

act ttc atg tac tcc gat ggc ctc atc cat aat agt ggc gac tgt cgg        288
Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg           
                85                  90                  95                

tct agc aca tgt gag gga ctc gat ctg ctc cga aaa att tcc aac gcc        336
Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala           
            100                 105                 110                   

cag cga atg gga tgt gtg ctc att gga ccc tct tgt acc tac tcc aca        384
Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr           
        115                 120                 125                       

ttt cag atg tac ctc gac acc gaa ctg tct tac ccc atg atc tct gcc        432
Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala           
    130                 135                 140                           

gga tcc ttt gga ctg tcc tgt gat tac aag gag aca ctc act aga ctc        480
Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu           
145                 150                 155                 160           

atg tcc ccc gct cga aaa ctc atg tac ttt ctc gtg aac ttc tgg aaa        528
Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys           
                165                 170                 175               

acc aac gac ctg ccc ttc aaa aca tac tcc tgg tca act tca tac gtc        576
Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val           
            180                 185                 190                   

tac aaa aac ggc acc gaa acc gag gat tgc ttt tgg tac ctc aat gcc        624
Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala           
        195                 200                 205                       

ctg gag gct agc gtg tca tac ttt agc cac gaa ctc gga ttc aaa gtc        672
Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val           
    210                 215                 220                           

gtg ctg agg cag gat aag gag ttc cag gat att ctc atg gac cat aac        720
Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn           
225                 230                 235                 240           

cgg aaa tca aac gtg atc atc atg tgt gga ggc cct gaa ttt ctg tac        768
Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr           
                245                 250                 255               

aaa ctc aag ggc gat aga gct gtg gct gag gat att gtc atc att ctc        816
Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu           
            260                 265                 270                   

gtg gat ctc ttc aac gac cag tac ttc gag gat aac gtg act gct ccc        864
Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro           
        275                 280                 285                       

gac tac atg aaa aac gtc ctg gtg ctc aca ctg agt cct ggc aat tcc        912
Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser           
    290                 295                 300                           

ctg ctg aat tcc tcc ttt tct cga aac ctg tcc cca aca aaa cgg gat        960
Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp           
305                 310                 315                 320           

ttt gct ctg gct tac ctg aac ggg att ctc ctg ttt ggc cac atg ctc       1008
Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu           
                325                 330                 335               

aaa atc ttt ctg gaa aat ggc gag aac atc acc acc ccc aaa ttt gct       1056
Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala           
            340                 345                 350                   

cac gcc ttc cgg aat ctc act ttt gag ggc tac gac gga cct gtg act       1104
His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr           
        355                 360                 365                       

ctg gac gat tgg ggc gac gtg gat agc aca atg gtg ctg ctc tac acc       1152
Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr           
    370                 375                 380                           

tct gtc gat act aaa aaa tac aaa gtc ctg ctc acc tac gat act cac       1200
Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His           
385                 390                 395                 400           

gtc aac aaa acc tac cct gtg gat atg agc cca acc ttc act tgg aaa       1248
Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys           
                405                 410                 415               

aac tcc aaa ctg cca aat gat att acc ggg cga gga ccc                   1287
Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro                       
            420                 425                                       


<210>  6
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro 
            420                 425                 


<210>  7
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence encoding a PADRE


<220>
<221>  CDS
<222>  (1)..(45)

<400>  7
gcc aaa ttc gtc gct gct tgg aca ctg aag gct gct gcc tag taa             45
Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala                       
1               5                   10                                    


<210>  8
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Ala Lys Phe Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
1               5                   10              


<210>  9
<211>  1332
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1329)

<400>  9
atg aaa aca ctg ctg ctg gat ctc gct ctg tgg tca ctc ctc ttt cag         48
Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln           
1               5                   10                  15                

ccc gga tgg ctg tca ttt tct tcc cag gtg tcc cag aat tgt cac aac         96
Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn           
            20                  25                  30                    

ggc tcc tac gaa atc tct gtc ctc atg atg ggc aat agc gcc ttt gcc        144
Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala           
        35                  40                  45                        

gaa cct ctc aaa aac ctc gag gat gct gtg aat gag gga ctg gag att        192
Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile           
    50                  55                  60                            

gtg agg gga cga ctc cag aac gct gga ctg aat gtc acc gtg aat gcc        240
Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala           
65                  70                  75                  80            

act ttc atg tac tcc gat ggc ctc atc cat aat agt ggc gac tgt cgg        288
Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg           
                85                  90                  95                

tct agc aca tgt gag gga ctc gat ctg ctc cga aaa att tcc aac gcc        336
Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala           
            100                 105                 110                   

cag cga atg gga tgt gtg ctc att gga ccc tct tgt acc tac tcc aca        384
Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr           
        115                 120                 125                       

ttt cag atg tac ctc gac acc gaa ctg tct tac ccc atg atc tct gcc        432
Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala           
    130                 135                 140                           

gga tcc ttt gga ctg tcc tgt gat tac aag gag aca ctc act aga ctc        480
Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu           
145                 150                 155                 160           

atg tcc ccc gct cga aaa ctc atg tac ttt ctc gtg aac ttc tgg aaa        528
Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys           
                165                 170                 175               

acc aac gac ctg ccc ttc aaa aca tac tcc tgg tca act tca tac gtc        576
Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val           
            180                 185                 190                   

tac aaa aac ggc acc gaa acc gag gat tgc ttt tgg tac ctc aat gcc        624
Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala           
        195                 200                 205                       

ctg gag gct agc gtg tca tac ttt agc cac gaa ctc gga ttc aaa gtc        672
Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val           
    210                 215                 220                           

gtg ctg agg cag gat aag gag ttc cag gat att ctc atg gac cat aac        720
Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn           
225                 230                 235                 240           

cgg aaa tca aac gtg atc atc atg tgt gga ggc cct gaa ttt ctg tac        768
Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr           
                245                 250                 255               

aaa ctc aag ggc gat aga gct gtg gct gag gat att gtc atc att ctc        816
Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu           
            260                 265                 270                   

gtg gat ctc ttc aac gac cag tac ttc gag gat aac gtg act gct ccc        864
Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro           
        275                 280                 285                       

gac tac atg aaa aac gtc ctg gtg ctc aca ctg agt cct ggc aat tcc        912
Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser           
    290                 295                 300                           

ctg ctg aat tcc tcc ttt tct cga aac ctg tcc cca aca aaa cgg gat        960
Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp           
305                 310                 315                 320           

ttt gct ctg gct tac ctg aac ggg att ctc ctg ttt ggc cac atg ctc       1008
Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu           
                325                 330                 335               

aaa atc ttt ctg gaa aat ggc gag aac atc acc acc ccc aaa ttt gct       1056
Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala           
            340                 345                 350                   

cac gcc ttc cgg aat ctc act ttt gag ggc tac gac gga cct gtg act       1104
His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr           
        355                 360                 365                       

ctg gac gat tgg ggc gac gtg gat agc aca atg gtg ctg ctc tac acc       1152
Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr           
    370                 375                 380                           

tct gtc gat act aaa aaa tac aaa gtc ctg ctc acc tac gat act cac       1200
Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His           
385                 390                 395                 400           

gtc aac aaa acc tac cct gtg gat atg agc cca acc ttc act tgg aaa       1248
Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys           
                405                 410                 415               

aac tcc aaa ctg cca aat gat att acc ggg cga gga ccc gcc aaa ttc       1296
Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Ala Lys Phe           
            420                 425                 430                   

gtc gct gct tgg aca ctg aag gct gct gcc tag taa                       1332
Val Ala Ala Trp Thr Leu Lys Ala Ala Ala                                   
        435                 440                                           


<210>  10
<211>  442
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Ala Lys Phe 
            420                 425                 430         


Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 
        435                 440         


<210>  11
<211>  32806
<212>  DNA
<213>  Adenovirus Vector

<400>  11
attaacatca tcaataatat accttatttt ggattgaagc caatatgata atgagggggt       60

ggagtttgtg acgtggcgcg gggcgtggga acggggcggg tgacgtagta gtgtggcgga      120

agtgtgatgt tgcaagtgtg gcggaacaca tgtaagcgac ggatgtggca aaagtgacgt      180

ttttggtgtg cgccggtgta cacaggaagt gacaattttc gcgcggtttt aggcggatgt      240

tgtagtaaat ttgggcgtaa ccgagtaaga tttggccatt ttcgcgggaa aactgaataa      300

gaggaagtga aatctgaata attttgtgtt actcatagcg cgtaatctct agcatcgtaa      360

ctataacggt cctaaggtag cgaaagctca gatctggatc tcccgatccc ctatggtcga      420

ctctcagtac aatctgctct gatgccgcat agttaagcca gtatctgctc cctgcttgtg      480

tgttggaggt cgctgagtag tgcgcgagca aaatttaagc tacaacaagg caaggcttga      540

ccgacaattg catgaagaat ctgcttaggg ttaggcgttt tgcgctgctt cgcgatgtac      600

gggccagata tacgcgttga cattgattat tgactagtta ttaatagtaa tcaattacgg      660

ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc      720

cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca      780

tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta cggtaaactg      840

cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt gacgtcaatg      900

acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac tttcctactt      960

ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca     1020

tcaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg     1080

tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaacaact     1140

ccgccccatt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag     1200

ctctctggct aactagagaa cccactgctt actggcttat cgaaattaat acgactcact     1260

atagggagac ccaagctggc tagcgtttaa acgggccctc tagagccgcc accatgaaaa     1320

cactgctgct ggatctcgct ctgtggtcac tcctctttca gcccggatgg ctgtcatttt     1380

cttcccaggt gtcccagaat tgtcacaacg gctcctacga aatctctgtc ctcatgatgg     1440

gcaatagcgc ctttgccgaa cctctcaaaa acctcgagga tgctgtgaat gagggactgg     1500

agattgtgag gggacgactc cagaacgctg gactgaatgt caccgtgaat gccactttca     1560

tgtactccga tggcctcatc cataatagtg gcgactgtcg gtctagcaca tgtgagggac     1620

tcgatctgct ccgaaaaatt tccaacgccc agcgaatggg atgtgtgctc attggaccct     1680

cttgtaccta ctccacattt cagatgtacc tcgacaccga actgtcttac cccatgatct     1740

ctgccggatc ctttggactg tcctgtgatt acaaggagac actcactaga ctcatgtccc     1800

ccgctcgaaa actcatgtac tttctcgtga acttctggaa aaccaacgac ctgcccttca     1860

aaacatactc ctggtcaact tcatacgtct acaaaaacgg caccgaaacc gaggattgct     1920

tttggtacct caatgccctg gaggctagcg tgtcatactt tagccacgaa ctcggattca     1980

aagtcgtgct gaggcaggat aaggagttcc aggatattct catggaccat aaccggaaat     2040

caaacgtgat catcatgtgt ggaggccctg aatttctgta caaactcaag ggcgatagag     2100

ctgtggctga ggatattgtc atcattctcg tggatctctt caacgaccag tacttcgagg     2160

ataacgtgac tgctcccgac tacatgaaaa acgtcctggt gctcacactg agtcctggca     2220

attccctgct gaattcctcc ttttctcgaa acctgtcccc aacaaaacgg gattttgctc     2280

tggcttacct gaacgggatt ctcctgtttg gccacatgct caaaatcttt ctggaaaatg     2340

gcgagaacat caccaccccc aaatttgctc acgccttccg gaatctcact tttgagggct     2400

acgacggacc tgtgactctg gacgattggg gcgacgtgga tagcacaatg gtgctgctct     2460

acacctctgt cgatactaaa aaatacaaag tcctgctcac ctacgatact cacgtcaaca     2520

aaacctaccc tgtggatatg agcccaacct tcacttggaa aaactccaaa ctgccaaatg     2580

atattaccgg gcgaggaccc gccaaattcg tcgctgcttg gacactgaag gctgctgcct     2640

agtaagcggc cgccactgtg ctggatgatc cgagctcggt accaagctta agtttaaacc     2700

gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg     2760

tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa     2820

ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca     2880

gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg ggctctatgg     2940

cttctgaggc ggaaagaacc agcagatctg cagatctgaa ttcatctatg tcgggtgcgg     3000

agaaagaggt aatgaaatgg catcgactcg aagatctggg cgtggttaag ggtgggaaag     3060

aatatataag gtgggggtct tatgtagttt tgtatctgtt ttgcagcagc cgccgccgcc     3120

atgagcacca actcgtttga tggaagcatt gtgagctcat atttgacaac gcgcatgccc     3180

ccatgggccg gggtgcgtca gaatgtgatg ggctccagca ttgatggtcg ccccgtcctg     3240

cccgcaaact ctactacctt gacctacgag accgtgtctg gaacgccgtt ggagactgca     3300

gcctccgccg ccgcttcagc cgctgcagcc accgcccgcg ggattgtgac tgactttgct     3360

ttcctgagcc cgcttgcaag cagtgcagct tcccgttcat ccgcccgcga tgacaagttg     3420

acggctcttt tggcacaatt ggattctttg acccgggaac ttaatgtcgt ttctcagcag     3480

ctgttggatc tgcgccagca ggtttctgcc ctgaaggctt cctcccctcc caatgcggtt     3540

taaaacataa ataaaaaacc agactctgtt tggatttgga tcaagcaagt gtcttgctgt     3600

ctttatttag gggttttgcg cgcgcggtag gcccgggacc agcggtctcg gtcgttgagg     3660

gtcctgtgta ttttttccag gacgtggtaa aggtgactct ggatgttcag atacatgggc     3720

ataagcccgt ctctggggtg gaggtagcac cactgcagag cttcatgctg cggggtggtg     3780

ttgtagatga tccagtcgta gcaggagcgc tgggcgtggt gcctaaaaat gtctttcagt     3840

agcaagctga ttgccagggg caggcccttg gtgtaagtgt ttacaaagcg gttaagctgg     3900

gatgggtgca tacgtgggga tatgagatgc atcttggact gtatttttag gttggctatg     3960

ttcccagcca tatccctccg gggattcatg ttgtgcagaa ccaccagcac agtgtatccg     4020

gtgcacttgg gaaatttgtc atgtagctta gaaggaaatg cgtggaagaa cttggagacg     4080

cccttgtgac ctccaagatt ttccatgcat tcgtccataa tgatggcaat gggcccacgg     4140

gcggcggcct gggcgaagat atttctggga tcactaacgt catagttgtg ttccaggatg     4200

agatcgtcat aggccatttt tacaaagcgc gggcggaggg tgccagactg cggtataatg     4260

gttccatccg gcccaggggc gtagttaccc tcacagattt gcatttccca cgctttgagt     4320

tcagatgggg ggatcatgtc tacctgcggg gcgatgaaga aaacggtttc cggggtaggg     4380

gagatcagct gggaagaaag caggttcctg agcagctgcg acttaccgca gccggtgggc     4440

ccgtaaatca cacctattac cgggtgcaac tggtagttaa gagagctgca gctgccgtca     4500

tccctgagca ggggggccac ttcgttaagc atgtccctga ctcgcatgtt ttccctgacc     4560

aaatccgcca gaaggcgctc gccgcccagc gatagcagtt cttgcaagga agcaaagttt     4620

ttcaacggtt tgagaccgtc cgccgtaggc atgcttttga gcgtttgacc aagcagttcc     4680

aggcggtccc acagctcggt cacctgctct acggcatctc gatccagcat atctcctcgt     4740

ttcgcgggtt ggggcggctt tcgctgtacg gcagtagtcg gtgctcgtcc agacgggcca     4800

gggtcatgtc tttccacggg cgcagggtcc tcgtcagcgt agtctgggtc acggtgaagg     4860

ggtgcgctcc gggctgcgcg ctggccaggg tgcgcttgag gctggtcctg ctggtgctga     4920

agcgctgccg gtcttcgccc tgcgcgtcgg ccaggtagca tttgaccatg gtgtcatagt     4980

ccagcccctc cgcggcgtgg cccttggcgc gcagcttgcc cttggaggag gcgccgcacg     5040

aggggcagtg cagacttttg agggcgtaga gcttgggcgc gagaaatacc gattccgggg     5100

agtaggcatc cgcgccgcag gccccgcaga cggtctcgca ttccacgagc caggtgagct     5160

ctggccgttc ggggtcaaaa accaggtttc ccccatgctt tttgatgcgt ttcttacctc     5220

tggtttccat gagccggtgt ccacgctcgg tgacgaaaag gctgtccgtg tccccgtata     5280

cagacttgag aggcctgtcc tcgagcggtg ttccgcggtc ctcctcgtat agaaactcgg     5340

accactctga gacaaaggct cgcgtccagg ccagcacgaa ggaggctaag tgggaggggt     5400

agcggtcgtt gtccactagg gggtccactc gctccagggt gtgaagacac atgtcgccct     5460

cttcggcatc aaggaaggtg attggtttgt aggtgtaggc cacgtgaccg ggtgttcctg     5520

aaggggggct ataaaagggg gtgggggcgc gttcgtcctc actctcttcc gcatcgctgt     5580

ctgcgagggc cagctgttgg ggtgagtact ccctctgaaa agcgggcatg acttctgcgc     5640

taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc gcggtgatgc     5700

ctttgagggt ggccgcatcc atctggtcag aaaagacaat ctttttgttg tcaagcttgg     5760

tggcaaacga cccgtagagg gcgttggaca gcaacttggc gatggagcgc agggtttggt     5820

ttttgtcgcg atcggcgcgc tccttggccg cgatgtttag ctgcacgtat tcgcgcgcaa     5880

cgcaccgcca ttcgggaaag acggtggtgc gctcgtcggg caccaggtgc acgcgccaac     5940

cgcggttgtg cagggtgaca aggtcaacgc tggtggctac ctctccgcgt aggcgctcgt     6000

tggtccagca gaggcggccg cccttgcgcg agcagaatgg cggtaggggg tctagctgcg     6060

tctcgtccgg ggggtctgcg tccacggtaa agaccccggg cagcaggcgc gcgtcgaagt     6120

agtctatctt gcatccttgc aagtctagcg cctgctgcca tgcgcgggcg gcaagcgcgc     6180

gctcgtatgg gttgagtggg ggaccccatg gcatggggtg ggtgagcgcg gaggcgtaca     6240

tgccgcaaat gtcgtaaacg tagaggggct ctctgagtat tccaagatat gtagggtagc     6300

atcttccacc gcggatgctg gcgcgcacgt aatcgtatag ttcgtgcgag ggagcgagga     6360

ggtcgggacc gaggttgcta cgggcgggct gctctgctcg gaagactatc tgcctgaaga     6420

tggcatgtga gttggatgat atggttggac gctggaagac gttgaagctg gcgtctgtga     6480

gacctaccgc gtcacgcacg aaggaggcgt aggagtcgcg cagcttgttg accagctcgg     6540

cggtgacctg cacgtctagg gcgcagtagt ccagggtttc cttgatgatg tcatacttat     6600

cctgtccctt ttttttccac agctcgcggt tgaggacaaa ctcttcgcgg tctttccagt     6660

actcttggat cggaaacccg tcggcctccg aacggtaaga gcctagcatg tagaactggt     6720

tgacggcctg gtaggcgcag catccctttt ctacgggtag cgcgtatgcc tgcgcggcct     6780

tccggagcga ggtgtgggtg agcgcaaagg tgtccctgac catgactttg aggtactggt     6840

atttgaagtc agtgtcgtcg catccgccct gctcccagag caaaaagtcc gtgcgctttt     6900

tggaacgcgg atttggcagg gcgaaggtga catcgttgaa gagtatcttt cccgcgcgag     6960

gcataaagtt gcgtgtgatg cggaagggtc ccggcacctc ggaacggttg ttaattacct     7020

gggcggcgag cacgatctcg tcaaagccgt tgatgttgtg gcccacaatg taaagttcca     7080

agaagcgcgg gatgcccttg atggaaggca attttttaag ttcctcgtag gtgagctctt     7140

caggggagct gagcccgtgc tctgaaaggg cccagtctgc aagatgaggg ttggaagcga     7200

cgaatgagct ccacaggtca cgggccatta gcatttgcag gtggtcgcga aaggtcctaa     7260

actggcgacc tatggccatt ttttctgggg tgatgcagta gaaggtaagc gggtcttgtt     7320

cccagcggtc ccatccaagg ttcgcggcta ggtctcgcgc ggcagtcact agaggctcat     7380

ctccgccgaa cttcatgacc agcatgaagg gcacgagctg cttcccaaag gcccccatcc     7440

aagtataggt ctctacatcg taggtgacaa agagacgctc ggtgcgagga tgcgagccga     7500

tcgggaagaa ctggatctcc cgccaccaat tggaggagtg gctattgatg tggtgaaagt     7560

agaagtccct gcgacgggcc gaacactcgt gctggctttt gtaaaaacgt gcgcagtact     7620

ggcagcggtg cacgggctgt acatcctgca cgaggttgac ctgacgaccg cgcacaagga     7680

agcagagtgg gaatttgagc ccctcgcctg gcgggtttgg ctggtggtct tctacttcgg     7740

ctgcttgtcc ttgaccgtct ggctgctcga ggggagttac ggtggatcgg accaccacgc     7800

cgcgcgagcc caaagtccag atgtccgcgc gcggcggtcg gagcttgatg acaacatcgc     7860

gcagatggga gctgtccatg gtctggagct cccgcggcgt caggtcaggc gggagctcct     7920

gcaggtttac ctcgcataga cgggtcaggg cgcgggctag atccaggtga tacctaattt     7980

ccaggggctg gttggtggcg gcgtcgatgg cttgcaagag gccgcatccc cgcggcgcga     8040

ctacggtacc gcgcggcggg cggtgggccg cgggggtgtc cttggatgat gcatctaaaa     8100

gcggtgacgc gggcgagccc ccggaggtag ggggggctcc ggacccgccg ggagaggggg     8160

caggggcacg tcggcgccgc gcgcgggcag gagctggtgc tgcgcgcgta ggttgctggc     8220

gaacgcgacg acgcggcggt tgatctcctg aatctggcgc ctctgcgtga agacgacggg     8280

cccggtgagc ttgagcctga aagagagttc gacagaatca atttcggtgt cgttgacggc     8340

ggcctggcgc aaaatctcct gcacgtctcc tgagttgtct tgataggcga tctcggccat     8400

gaactgctcg atctcttcct cctggagatc tccgcgtccg gctcgctcca cggtggcggc     8460

gaggtcgttg gaaatgcggg ccatgagctg cgagaaggcg ttgaggcctc cctcgttcca     8520

gacgcggctg tagaccacgc ccccttcggc atcgcgggcg cgcatgacca cctgcgcgag     8580

attgagctcc acgtgccggg cgaagacggc gtagtttcgc aggcgctgaa agaggtagtt     8640

gagggtggtg gcggtgtgtt ctgccacgaa gaagtacata acccagcgtc gcaacgtgga     8700

ttcgttgata tcccccaagg cctcaaggcg ctccatggcc tcgtagaagt ccacggcgaa     8760

gttgaaaaac tgggagttgc gcgccgacac ggttaactcc tcctccagaa gacggatgag     8820

ctcggcgaca gtgtcgcgca cctcgcgctc aaaggctaca ggggcctctt cttcttcttc     8880

aatctcctct tccataaggg cctccccttc ttcttcttct ggcggcggtg ggggaggggg     8940

gacacggcgg cgacgacggc gcaccgggag gcggtcgaca aagcgctcga tcatctcccc     9000

gcggcgacgg cgcatggtct cggtgacggc gcggccgttc tcgcgggggc gcagttggaa     9060

gacgccgccc gtcatgtccc ggttatgggt tggcgggggg ctgccatgcg gcagggatac     9120

ggcgctaacg atgcatctca acaattgttg tgtaggtact ccgccgccga gggacctgag     9180

cgagtccgca tcgaccggat cggaaaacct ctcgagaaag gcgtctaacc agtcacagtc     9240

gcaaggtagg ctgagcaccg tggcgggcgg cagcgggcgg cggtcggggt tgtttctggc     9300

ggaggtgctg ctgatgatgt aattaaagta ggcggtcttg agacggcgga tggtcgacag     9360

aagcaccatg tccttgggtc cggcctgctg aatgcgcagg cggtcggcca tgccccaggc     9420

ttcgttttga catcggcgca ggtctttgta gtagtcttgc atgagccttt ctaccggcac     9480

ttcttcttct ccttcctctt gtcctgcatc tcttgcatct atcgctgcgg cggcggcgga     9540

gtttggccgt aggtggcgcc ctcttcctcc catgcgtgtg accccgaagc ccctcatcgg     9600

ctgaagcagg gctaggtcgg cgacaacgcg ctcggctaat atggcctgct gcacctgcgt     9660

gagggtagac tggaagtcat ccatgtccac aaagcggtgg tatgcgcccg tgttgatggt     9720

gtaagtgcag ttggccataa cggaccagtt aacggtctgg tgacccggct gcgagagctc     9780

ggtgtacctg agacgcgagt aagccctcga gtcaaatacg tagtcgttgc aagtccgcac     9840

caggtactgg tatcccacca aaaagtgcgg cggcggctgg cggtagaggg gccagcgtag     9900

ggtggccggg gctccggggg cgagatcttc caacataagg cgatgatatc cgtagatgta     9960

cctggacatc caggtgatgc cggcggcggt ggtggaggcg cgcggaaagt cgcggacgcg    10020

gttccagatg ttgcgcagcg gcaaaaagtg ctccatggtc gggacgctct ggccggtcag    10080

gcgcgcgcaa tcgttgacgc tctagaccgt gcaaaaggag agcctgtaag cgggcactct    10140

tccgtggtct ggtggataaa ttcgcaaggg tatcatggcg gacgaccggg gttcgagccc    10200

cgtatccggc cgtccgccgt gatccatgcg gttaccgccc gcgtgtcgaa cccaggtgtg    10260

cgacgtcaga caacggggga gtgctccttt tggcttcctt ccaggcgcgg cggctgctgc    10320

gctagctttt ttggccactg gccgcgcgca gcgtaagcgg ttaggctgga aagcgaaagc    10380

attaagtggc tcgctccctg tagccggagg gttattttcc aagggttgag tcgcgggacc    10440

cccggttcga gtctcggacc ggccggactg cggcgaacgg gggtttgcct ccccgtcatg    10500

caagaccccg cttgcaaatt cctccggaaa cagggacgag cccctttttt gcttttccca    10560

gatgcatccg gtgctgcggc agatgcgccc ccctcctcag cagcggcaag agcaagagca    10620

gcggcagaca tgcagggcac cctcccctcc tcctaccgcg tcaggagggg cgacatccgc    10680

ggttgacgcg gcagcagatg gtgattacga acccccgcgg cgccgggccc ggcactacct    10740

ggacttggag gagggcgagg gcctggcgcg gctaggagcg ccctctcctg agcggtaccc    10800

aagggtgcag ctgaagcgtg atacgcgtga ggcgtacgtg ccgcggcaga acctgtttcg    10860

cgaccgcgag ggagaggagc ccgaggagat gcgggatcga aagttccacg cagggcgcga    10920

gctgcggcat ggcctgaatc gcgagcggtt gctgcgcgag gaggactttg agcccgacgc    10980

gcgaaccggg attagtcccg cgcgcgcaca cgtggcggcc gccgacctgg taaccgcata    11040

cgagcagacg gtgaaccagg agattaactt tcaaaaaagc tttaacaacc acgtgcgtac    11100

gcttgtggcg cgcgaggagg tggctatagg actgatgcat ctgtgggact ttgtaagcgc    11160

gctggagcaa aacccaaata gcaagccgct catggcgcag ctgttcctta tagtgcagca    11220

cagcagggac aacgaggcat tcagggatgc gctgctaaac atagtagagc ccgagggccg    11280

ctggctgctc gatttgataa acatcctgca gagcatagtg gtgcaggagc gcagcttgag    11340

cctggctgac aaggtggccg ccatcaacta ttccatgctt agcctgggca agttttacgc    11400

ccgcaagata taccataccc cttacgttcc catagacaag gaggtaaaga tcgaggggtt    11460

ctacatgcgc atggcgctga aggtgcttac cttgagcgac gacctgggcg tttatcgcaa    11520

cgagcgcatc cacaaggccg tgagcgtgag ccggcggcgc gagctcagcg accgcgagct    11580

gatgcacagc ctgcaaaggg ccctggctgg cacgggcagc ggcgatagag aggccgagtc    11640

ctactttgac gcgggcgctg acctgcgctg ggccccaagc cgacgcgccc tggaggcagc    11700

tggggccgga cctgggctgg cggtggcacc cgcgcgcgct ggcaacgtcg gcggcgtgga    11760

ggaatatgac gaggacgatg agtacgagcc agaggacggc gagtactaag cggtgatgtt    11820

tctgatcaga tgatgcaaga cgcaacggac ccggcggtgc gggcggcgct gcagagccag    11880

ccgtccggcc ttaactccac ggacgactgg cgccaggtca tggaccgcat catgtcgctg    11940

actgcgcgca atcctgacgc gttccggcag cagccgcagg ccaaccggct ctccgcaatt    12000

ctggaagcgg tggtcccggc gcgcgcaaac cccacgcacg agaaggtgct ggcgatcgta    12060

aacgcgctgg ccgaaaacag ggccatccgg cccgacgagg ccggcctggt ctacgacgcg    12120

ctgcttcagc gcgtggctcg ttacaacagc ggcaacgtgc agaccaacct ggaccggctg    12180

gtgggggatg tgcgcgaggc cgtggcgcag cgtgagcgcg cgcagcagca gggcaacctg    12240

ggctccatgg ttgcactaaa cgccttcctg agtacacagc ccgccaacgt gccgcgggga    12300

caggaggact acaccaactt tgtgagcgca ctgcggctaa tggtgactga gacaccgcaa    12360

agtgaggtgt accagtctgg gccagactat tttttccaga ccagtagaca aggcctgcag    12420

accgtaaacc tgagccaggc tttcaaaaac ttgcaggggc tgtggggggt gcgggctccc    12480

acaggcgacc gcgcgaccgt gtctagcttg ctgacgccca actcgcgcct gttgctgctg    12540

ctaatagcgc ccttcacgga cagtggcagc gtgtcccggg acacatacct aggtcacttg    12600

ctgacactgt accgcgaggc cataggtcag gcgcatgtgg acgagcatac tttccaggag    12660

attacaagtg tcagccgcgc gctggggcag gaggacacgg gcagcctgga ggcaacccta    12720

aactacctgc tgaccaaccg gcggcagaag atcccctcgt tgcacagttt aaacagcgag    12780

gaggagcgca ttttgcgcta cgtgcagcag agcgtgagcc ttaacctgat gcgcgacggg    12840

gtaacgccca gcgtggcgct ggacatgacc gcgcgcaaca tggaaccggg catgtatgcc    12900

tcaaaccggc cgtttatcaa ccgcctaatg gactacttgc atcgcgcggc cgccgtgaac    12960

cccgagtatt tcaccaatgc catcttgaac ccgcactggc taccgccccc tggtttctac    13020

accgggggat tcgaggtgcc cgagggtaac gatggattcc tctgggacga catagacgac    13080

agcgtgtttt ccccgcaacc gcagaccctg ctagagttgc aacagcgcga gcaggcagag    13140

gcggcgctgc gaaaggaaag cttccgcagg ccaagcagct tgtccgatct aggcgctgcg    13200

gccccgcggt cagatgctag tagcccattt ccaagcttga tagggtctct taccagcact    13260

cgcaccaccc gcccgcgcct gctgggcgag gaggagtacc taaacaactc gctgctgcag    13320

ccgcagcgcg aaaaaaacct gcctccggca tttcccaaca acgggataga gagcctagtg    13380

gacaagatga gtagatggaa gacgtacgcg caggagcaca gggacgtgcc aggcccgcgc    13440

ccgcccaccc gtcgtcaaag gcacgaccgt cagcggggtc tggtgtggga ggacgatgac    13500

tcggcagacg acagcagcgt cctggatttg ggagggagtg gcaacccgtt tgcgcacctt    13560

cgccccaggc tggggagaat gttttaaaaa aaaaaaagca tgatgcaaaa taaaaaactc    13620

accaaggcca tggcaccgag cgttggtttt cttgtattcc ccttagtatg cggcgcgcgg    13680

cgatgtatga ggaaggtcct cctccctcct acgagagtgt ggtgagcgcg gcgccagtgg    13740

cggcggcgct gggttctccc ttcgatgctc ccctggaccc gccgtttgtg cctccgcggt    13800

acctgcggcc taccgggggg agaaacagca tccgttactc tgagttggca cccctattcg    13860

acaccacccg tgtgtacctg gtggacaaca agtcaacgga tgtggcatcc ctgaactacc    13920

agaacgacca cagcaacttt ctgaccacgg tcattcaaaa caatgactac agcccggggg    13980

aggcaagcac acagaccatc aatcttgacg accggtcgca ctggggcggc gacctgaaaa    14040

ccatcctgca taccaacatg ccaaatgtga acgagttcat gtttaccaat aagtttaagg    14100

cgcgggtgat ggtgtcgcgc ttgcctacta aggacaatca ggtggagctg aaatacgagt    14160

gggtggagtt cacgctgccc gagggcaact actccgagac catgaccata gaccttatga    14220

acaacgcgat cgtggagcac tacttgaaag tgggcagaca gaacggggtt ctggaaagcg    14280

acatcggggt aaagtttgac acccgcaact tcagactggg gtttgacccc gtcactggtc    14340

ttgtcatgcc tggggtatat acaaacgaag ccttccatcc agacatcatt ttgctgccag    14400

gatgcggggt ggacttcacc cacagccgcc tgagcaactt gttgggcatc cgcaagcggc    14460

aacccttcca ggagggcttt aggatcacct acgatgatct ggagggtggt aacattcccg    14520

cactgttgga tgtggacgcc taccaggcga gcttgaaaga tgacaccgaa cagggcgggg    14580

gtggcgcagg cggcagcaac agcagtggca gcggcgcgga agagaactcc aacgcggcag    14640

ccgcggcaat gcagccggtg gaggacatga acgatcatgc cattcgcggc gacacctttg    14700

ccacacgggc tgaggagaag cgcgctgagg ccgaagcagc ggccgaagct gccgcccccg    14760

ctgcgcaacc cgaggtcgag aagcctcaga agaaaccggt gatcaaaccc ctgacagagg    14820

acagcaagaa acgcagttac aacctaataa gcaatgacag caccttcacc cagtaccgca    14880

gctggtacct tgcatacaac tacggcgacc ctcagaccgg aatccgctca tggaccctgc    14940

tttgcactcc tgacgtaacc tgcggctcgg agcaggtcta ctggtcgttg ccagacatga    15000

tgcaagaccc cgtgaccttc cgctccacgc gccagatcag caactttccg gtggtgggcg    15060

ccgagctgtt gcccgtgcac tccaagagct tctacaacga ccaggccgtc tactcccaac    15120

tcatccgcca gtttacctct ctgacccacg tgttcaatcg ctttcccgag aaccagattt    15180

tggcgcgccc gccagccccc accatcacca ccgtcagtga aaacgttcct gctctcacag    15240

atcacgggac gctaccgctg cgcaacagca tcggaggagt ccagcgagtg accattactg    15300

acgccagacg ccgcacctgc ccctacgttt acaaggccct gggcatagtc tcgccgcgcg    15360

tcctatcgag ccgcactttt tgagcaagca tgtccatcct tatatcgccc agcaataaca    15420

caggctgggg cctgcgcttc ccaagcaaga tgtttggcgg ggccaagaag cgctccgacc    15480

aacacccagt gcgcgtgcgc gggcactacc gcgcgccctg gggcgcgcac aaacgcggcc    15540

gcactgggcg caccaccgtc gatgacgcca tcgacgcggt ggtggaggag gcgcgcaact    15600

acacgcccac gccgccacca gtgtccacag tggacgcggc cattcagacc gtggtgcgcg    15660

gagcccggcg ctatgctaaa atgaagagac ggcggaggcg cgtagcacgt cgccaccgcc    15720

gccgacccgg cactgccgcc caacgcgcgg cggcggccct gcttaaccgc gcacgtcgca    15780

ccggccgacg ggcggccatg cgggccgctc gaaggctggc cgcgggtatt gtcactgtgc    15840

cccccaggtc caggcgacga gcggccgccg cagcagccgc ggccattagt gctatgactc    15900

agggtcgcag gggcaacgtg tattgggtgc gcgactcggt tagcggcctg cgcgtgcccg    15960

tgcgcacccg ccccccgcgc aactagattg caagaaaaaa ctacttagac tcgtactgtt    16020

gtatgtatcc agcggcggcg gcgcgcaacg aagctatgtc caagcgcaaa atcaaagaag    16080

agatgctcca ggtcatcgcg ccggagatct atggcccccc gaagaaggaa gagcaggatt    16140

acaagccccg aaagctaaag cgggtcaaaa agaaaaagaa agatgatgat gatgaacttg    16200

acgacgaggt ggaactgctg cacgctaccg cgcccaggcg acgggtacag tggaaaggtc    16260

gacgcgtaaa acgtgttttg cgacccggca ccaccgtagt ctttacgccc ggtgagcgct    16320

ccacccgcac ctacaagcgc gtgtatgatg aggtgtacgg cgacgaggac ctgcttgagc    16380

aggccaacga gcgcctcggg gagtttgcct acggaaagcg gcataaggac atgctggcgt    16440

tgccgctgga cgagggcaac ccaacaccta gcctaaagcc cgtaacactg cagcaggtgc    16500

tgcccgcgct tgcaccgtcc gaagaaaagc gcggcctaaa gcgcgagtct ggtgacttgg    16560

cacccaccgt gcagctgatg gtacccaagc gccagcgact ggaagatgtc ttggaaaaaa    16620

tgaccgtgga acctgggctg gagcccgagg tccgcgtgcg gccaatcaag caggtggcgc    16680

cgggactggg cgtgcagacc gtggacgttc agatacccac taccagtagc accagtattg    16740

ccaccgccac agagggcatg gagacacaaa cgtccccggt tgcctcagcg gtggcggatg    16800

ccgcggtgca ggcggtcgct gcggccgcgt ccaagacctc tacggaggtg caaacggacc    16860

cgtggatgtt tcgcgtttca gccccccggc gcccgcgcgg ttcgaggaag tacggcgccg    16920

ccagcgcgct actgcccgaa tatgccctac atccttccat tgcgcctacc cccggctatc    16980

gtggctacac ctaccgcccc agaagacgag caactacccg acgccgaacc accactggaa    17040

cccgccgccg ccgtcgccgt cgccagcccg tgctggcccc gatttccgtg cgcagggtgg    17100

ctcgcgaagg aggcaggacc ctggtgctgc caacagcgcg ctaccacccc agcatcgttt    17160

aaaagccggt ctttgtggtt cttgcagata tggccctcac ctgccgcctc cgtttcccgg    17220

tgccgggatt ccgaggaaga atgcaccgta ggaggggcat ggccggccac ggcctgacgg    17280

gcggcatgcg tcgtgcgcac caccggcggc ggcgcgcgtc gcaccgtcgc atgcgcggcg    17340

gtatcctgcc cctccttatt ccactgatcg ccgcggcgat tggcgccgtg cccggaattg    17400

catccgtggc cttgcaggcg cagagacact gattaaaaac aagttgcatg tggaaaaatc    17460

aaaataaaaa gtctggactc tcacgctcgc ttggtcctgt aactattttg tagaatggaa    17520

gacatcaact ttgcgtctct ggccccgcga cacggctcgc gcccgttcat gggaaactgg    17580

caagatatcg gcaccagcaa tatgagcggt ggcgccttca gctggggctc gctgtggagc    17640

ggcattaaaa atttcggttc caccgttaag aactatggca gcaaggcctg gaacagcagc    17700

acaggccaga tgctgaggga taagttgaaa gagcaaaatt tccaacaaaa ggtggtagat    17760

ggcctggcct ctggcattag cggggtggtg gacctggcca accaggcagt gcaaaataag    17820

attaacagta agcttgatcc ccgccctccc gtagaggagc ctccaccggc cgtggagaca    17880

gtgtctccag aggggcgtgg cgaaaagcgt ccgcgccccg acagggaaga aactctggtg    17940

acgcaaatag acgagcctcc ctcgtacgag gaggcactaa agcaaggcct gcccaccacc    18000

cgtcccatcg cgcccatggc taccggagtg ctgggccagc acacacccgt aacgctggac    18060

ctgcctcccc ccgccgacac ccagcagaaa cctgtgctgc caggcccgac cgccgttgtt    18120

gtaacccgtc ctagccgcgc gtccctgcgc cgcgccgcca gcggtccgcg atcgttgcgg    18180

cccgtagcca gtggcaactg gcaaagcaca ctgaacagca tcgtgggtct gggggtgcaa    18240

tccctgaagc gccgacgatg cttctgaata gctaacgtgt cgtatgtgtg tcatgtatgc    18300

gtccatgtcg ccgccagagg agctgctgag ccgccgcgcg cccgctttcc aagatggcta    18360

ccccttcgat gatgccgcag tggtcttaca tgcacatctc gggccaggac gcctcggagt    18420

acctgagccc cgggctggtg cagtttgccc gcgccaccga gacgtacttc agcctgaata    18480

acaagtttag aaaccccacg gtggcgccta cgcacgacgt gaccacagac cggtcccagc    18540

gtttgacgct gcggttcatc cctgtggacc gtgaggatac tgcgtactcg tacaaggcgc    18600

ggttcaccct agctgtgggt gataaccgtg tgctggacat ggcttccacg tactttgaca    18660

tccgcggcgt gctggacagg ggccctactt ttaagcccta ctctggcact gcctacaacg    18720

ccctggctcc caagggtgcc ccaaatcctt gcgaatggga tgaagctgct actgctcttg    18780

aaataaacct agaagaagag gacgatgaca acgaagacga agtagacgag caagctgagc    18840

agcaaaaaac tcacgtattt gggcaggcgc cttattctgg tataaatatt acaaaggagg    18900

gtattcaaat aggtgtcgaa ggtcaaacac ctaaatatgc cgataaaaca tttcaacctg    18960

aacctcaaat aggagaatct cagtggtacg aaactgaaat taatcatgca gctgggagag    19020

tccttaaaaa gactacccca atgaaaccat gttacggttc atatgcaaaa cccacaaatg    19080

aaaatggagg gcaaggcatt cttgtaaagc aacaaaatgg aaagctagaa agtcaagtgg    19140

aaatgcaatt tttctcaact actgaggcga ccgcaggcaa tggtgataac ttgactccta    19200

aagtggtatt gtacagtgaa gatgtagata tagaaacccc agacactcat atttcttaca    19260

tgcccactat taaggaaggt aactcacgag aactaatggg ccaacaatct atgcccaaca    19320

ggcctaatta cattgctttt agggacaatt ttattggtct aatgtattac aacagcacgg    19380

gtaatatggg tgttctggcg ggccaagcat cgcagttgaa tgctgttgta gatttgcaag    19440

acagaaacac agagctttca taccagcttt tgcttgattc cattggtgat agaaccaggt    19500

acttttctat gtggaatcag gctgttgaca gctatgatcc agatgttaga attattgaaa    19560

atcatggaac tgaagatgaa cttccaaatt actgctttcc actgggaggt gtgattaata    19620

cagagactct taccaaggta aaacctaaaa caggtcagga aaatggatgg gaaaaagatg    19680

ctacagaatt ttcagataaa aatgaaataa gagttggaaa taattttgcc atggaaatca    19740

atctaaatgc caacctgtgg agaaatttcc tgtactccaa catagcgctg tatttgcccg    19800

acaagctaaa gtacagtcct tccaacgtaa aaatttctga taacccaaac acctacgact    19860

acatgaacaa gcgagtggtg gctcccgggt tagtggactg ctacattaac cttggagcac    19920

gctggtccct tgactatatg gacaacgtca acccatttaa ccaccaccgc aatgctggcc    19980

tgcgctaccg ctcaatgttg ctgggcaatg gtcgctatgt gcccttccac atccaggtgc    20040

ctcagaagtt ctttgccatt aaaaacctcc ttctcctgcc gggctcatac acctacgagt    20100

ggaacttcag gaaggatgtt aacatggttc tgcagagctc cctaggaaat gacctaaggg    20160

ttgacggagc cagcattaag tttgatagca tttgccttta cgccaccttc ttccccatgg    20220

cccacaacac cgcctccacg cttgaggcca tgcttagaaa cgacaccaac gaccagtcct    20280

ttaacgacta tctctccgcc gccaacatgc tctaccctat acccgccaac gctaccaacg    20340

tgcccatatc catcccctcc cgcaactggg cggctttccg cggctgggcc ttcacgcgcc    20400

ttaagactaa ggaaacccca tcactgggct cgggctacga cccttattac acctactctg    20460

gctctatacc ctacctagat ggaacctttt acctcaacca cacctttaag aaggtggcca    20520

ttacctttga ctcttctgtc agctggcctg gcaatgaccg cctgcttacc cccaacgagt    20580

ttgaaattaa gcgctcagtt gacggggagg gttacaacgt tgcccagtgt aacatgacca    20640

aagactggtt cctggtacaa atgctagcta actacaacat tggctaccag ggcttctata    20700

tcccagagag ctacaaggac cgcatgtact ccttctttag aaacttccag cccatgagcc    20760

gtcaggtggt ggatgatact aaatacaagg actaccaaca ggtgggcatc ctacaccaac    20820

acaacaactc tggatttgtt ggctaccttg cccccaccat gcgcgaagga caggcctacc    20880

ctgctaactt cccctatccg cttataggca agaccgcagt tgacagcatt acccagaaaa    20940

agtttctttg cgatcgcacc ctttggcgca tcccattctc cagtaacttt atgtccatgg    21000

gcgcactcac agacctgggc caaaaccttc tctacgccaa ctccgcccac gcgctagaca    21060

tgacttttga ggtggatccc atggacgagc ccacccttct ttatgttttg tttgaagtct    21120

ttgacgtggt ccgtgtgcac cggccgcacc gcggcgtcat cgaaaccgtg tacctgcgca    21180

cgcccttctc ggccggcaac gccacaacat aaagaagcaa gcaacatcaa caacagctgc    21240

cgccatgggc tccagtgagc aggaactgaa agccattgtc aaagatcttg gttgtgggcc    21300

atattttttg ggcacctatg acaagcgctt tccaggcttt gtttctccac acaagctcgc    21360

ctgcgccata gtcaatacgg ccggtcgcga gactgggggc gtacactgga tggcctttgc    21420

ctggaacccg cactcaaaaa catgctacct ctttgagccc tttggctttt ctgaccagcg    21480

actcaagcag gtttaccagt ttgagtacga gtcactcctg cgccgtagcg ccattgcttc    21540

ttcccccgac cgctgtataa cgctggaaaa gtccacccaa agcgtacagg ggcccaactc    21600

ggccgcctgt ggactattct gctgcatgtt tctccacgcc tttgccaact ggccccaaac    21660

tcccatggat cacaacccca ccatgaacct tattaccggg gtacccaact ccatgctcaa    21720

cagtccccag gtacagccca ccctgcgtcg caaccaggaa cagctctaca gcttcctgga    21780

gcgccactcg ccctacttcc gcagccacag tgcgcagatt aggagcgcca cttctttttg    21840

tcacttgaaa aacatgtaaa aataatgtac tagagacact ttcaataaag gcaaatgctt    21900

ttatttgtac actctcgggt gattatttac ccccaccctt gccgtctgcg ccgtttaaaa    21960

atcaaagggg ttctgccgcg catcgctatg cgccactggc agggacacgt tgcgatactg    22020

gtgtttagtg ctccacttaa actcaggcac aaccatccgc ggcagctcgg tgaagttttc    22080

actccacagg ctgcgcacca tcaccaacgc gtttagcagg tcgggcgccg atatcttgaa    22140

gtcgcagttg gggcctccgc cctgcgcgcg cgagttgcga tacacagggt tgcagcactg    22200

gaacactatc agcgccgggt ggtgcacgct ggccagcacg ctcttgtcgg agatcagatc    22260

cgcgtccagg tcctccgcgt tgctcagggc gaacggagtc aactttggta gctgccttcc    22320

caaaaagggc gcgtgcccag gctttgagtt gcactcgcac cgtagtggca tcaaaaggtg    22380

accgtgcccg gtctgggcgt taggatacag cgcctgcata aaagccttga tctgcttaaa    22440

agccacctga gcctttgcgc cttcagagaa gaacatgccg caagacttgc cggaaaactg    22500

attggccgga caggccgcgt cgtgcacgca gcaccttgcg tcggtgttgg agatctgcac    22560

cacatttcgg ccccaccggt tcttcacgat cttggccttg ctagactgct ccttcagcgc    22620

gcgctgcccg ttttcgctcg tcacatccat ttcaatcacg tgctccttat ttatcataat    22680

gcttccgtgt agacacttaa gctcgccttc gatctcagcg cagcggtgca gccacaacgc    22740

gcagcccgtg ggctcgtgat gcttgtaggt cacctctgca aacgactgca ggtacgcctg    22800

caggaatcgc cccatcatcg tcacaaaggt cttgttgctg gtgaaggtca gctgcaaccc    22860

gcggtgctcc tcgttcagcc aggtcttgca tacggccgcc agagcttcca cttggtcagg    22920

cagtagtttg aagttcgcct ttagatcgtt atccacgtgg tacttgtcca tcagcgcgcg    22980

cgcagcctcc atgcccttct cccacgcaga cacgatcggc acactcagcg ggttcatcac    23040

cgtaatttca ctttccgctt cgctgggctc ttcctcttcc tcttgcgtcc gcataccacg    23100

cgccactggg tcgtcttcat tcagccgccg cactgtgcgc ttacctcctt tgccatgctt    23160

gattagcacc ggtgggttgc tgaaacccac catttgtagc gccacatctt ctctttcttc    23220

ctcgctgtcc acgattacct ctggtgatgg cgggcgctcg ggcttgggag aagggcgctt    23280

ctttttcttc ttgggcgcaa tggccaaatc cgccgccgag gtcgatggcc gcgggctggg    23340

tgtgcgcggc accagcgcgt cttgtgatga gtcttcctcg tcctcggact cgatacgccg    23400

cctcatccgc ttttttgggg gcgcccgggg aggcggcggc gacggggacg gggacgacac    23460

gtcctccatg gttgggggac gtcgcgccgc accgcgtccg cgctcggggg tggtttcgcg    23520

ctgctcctct tcccgactgg ccatttcctt ctcctatagg cagaaaaaga tcatggagtc    23580

agtcgagaag aaggacagcc taaccgcccc ctctgagttc gccaccaccg cctccaccga    23640

tgccgccaac gcgcctacca ccttccccgt cgaggcaccc ccgcttgagg aggaggaagt    23700

gattatcgag caggacccag gttttgtaag cgaagacgac gaggaccgct cagtaccaac    23760

agaggataaa aagcaagacc aggacaacgc agaggcaaac gaggaacaag tcgggcgggg    23820

ggacgaaagg catggcgact acctagatgt gggagacgac gtgctgttga agcatctgca    23880

gcgccagtgc gccattatct gcgacgcgtt gcaagagcgc agcgatgtgc ccctcgccat    23940

agcggatgtc agccttgcct acgaacgcca cctattctca ccgcgcgtac cccccaaacg    24000

ccaagaaaac ggcacatgcg agcccaaccc gcgcctcaac ttctaccccg tatttgccgt    24060

gccagaggtg cttgccacct atcacatctt tttccaaaac tgcaagatac ccctatcctg    24120

ccgtgccaac cgcagccgag cggacaagca gctggccttg cggcagggcg ctgtcatacc    24180

tgatatcgcc tcgctcaacg aagtgccaaa aatctttgag ggtcttggac gcgacgagaa    24240

gcgcgcggca aacgctctgc aacaggaaaa cagcgaaaat gaaagtcact ctggagtgtt    24300

ggtggaactc gagggtgaca acgcgcgcct agccgtacta aaacgcagca tcgaggtcac    24360

ccactttgcc tacccggcac ttaacctacc ccccaaggtc atgagcacag tcatgagtga    24420

gctgatcgtg cgccgtgcgc agcccctgga gagggatgca aatttgcaag aacaaacaga    24480

ggagggccta cccgcagttg gcgacgagca gctagcgcgc tggcttcaaa cgcgcgagcc    24540

tgccgacttg gaggagcgac gcaaactaat gatggccgca gtgctcgtta ccgtggagct    24600

tgagtgcatg cagcggttct ttgctgaccc ggagatgcag cgcaagctag aggaaacatt    24660

gcactacacc tttcgacagg gctacgtacg ccaggcctgc aagatctcca acgtggagct    24720

ctgcaacctg gtctcctacc ttggaatttt gcacgaaaac cgccttgggc aaaacgtgct    24780

tcattccacg ctcaagggcg aggcgcgccg cgactacgtc cgcgactgcg tttacttatt    24840

tctatgctac acctggcaga cggccatggg cgtttggcag cagtgcttgg aggagtgcaa    24900

cctcaaggag ctgcagaaac tgctaaagca aaacttgaag gacctatgga cggccttcaa    24960

cgagcgctcc gtggccgcgc acctggcgga catcattttc cccgaacgcc tgcttaaaac    25020

cctgcaacag ggtctgccag acttcaccag tcaaagcatg ttgcagaact ttaggaactt    25080

tatcctagag cgctcaggaa tcttgcccgc cacctgctgt gcacttccta gcgactttgt    25140

gcccattaag taccgcgaat gccctccgcc gctttggggc cactgctacc ttctgcagct    25200

agccaactac cttgcctacc actctgacat aatggaagac gtgagcggtg acggtctact    25260

ggagtgtcac tgtcgctgca acctatgcac cccgcaccgc tccctggttt gcaattcgca    25320

gctgcttaac gaaagtcaaa ttatcggtac ctttgagctg cagggtccct cgcctgacga    25380

aaagtccgcg gctccggggt tgaaactcac tccggggctg tggacgtcgg cttaccttcg    25440

caaatttgta cctgaggact accacgccca cgagattagg ttctacgaag accaatcccg    25500

cccgccaaat gcggagctta ccgcctgcgt cattacccag ggccacattc ttggccaatt    25560

gcaagccatc aacaaagccc gccaagagtt tctgctacga aagggacggg gggtttactt    25620

ggacccccag tccggcgagg agctcaaccc aatccccccg ccgccgcagc cctatcagca    25680

gcagccgcgg gcccttgctt cccaggatgg cacccaaaaa gaagctgcag ctgccgccgc    25740

cacccacgga cgaggaggaa tactgggaca gtcaggcaga ggaggttttg gacgaggagg    25800

aggaggacat gatggaagac tgggagagcc tagacgagga agcttccgag gtcgaagagg    25860

tgtcagacga aacaccgtca ccctcggtcg cattcccctc gccggcgccc cagaaatcgg    25920

caaccggttc cagcatggct acaacctccg ctcctcaggc gccgccggca ctgcccgttc    25980

gccgacccaa ccgtagatgg gacaccactg gaaccagggc cggtaagtcc aagcagccgc    26040

cgccgttagc ccaagagcaa caacagcgcc aaggctaccg ctcatggcgc gggcacaaga    26100

acgccatagt tgcttgcttg caagactgtg ggggcaacat ctccttcgcc cgccgctttc    26160

ttctctacca tcacggcgtg gccttccccc gtaacatcct gcattactac cgtcatctct    26220

acagcccata ctgcaccggc ggcagcggca gcggcagcaa cagcagcggc cacacagaag    26280

caaaggcgac cggatagcaa gactctgaca aagcccaaga aatccacagc ggcggcagca    26340

gcaggaggag gagcgctgcg tctggcgccc aacgaacccg tatcgacccg cgagcttaga    26400

aacaggattt ttcccactct gtatgctata tttcaacaga gcaggggcca agaacaagag    26460

ctgaaaataa aaaacaggtc tctgcgatcc ctcacccgca gctgcctgta tcacaaaagc    26520

gaagatcagc ttcggcgcac gctggaagac gcggaggctc tcttcagtaa atactgcgcg    26580

ctgactctta aggactagtt tcgcgccctt tctcaaattt aagcgcgaaa actacgtcat    26640

ctccagcggc cacacccggc gccagcacct gtcgtcagcg ccattatgag caaggaaatt    26700

cccacgccct acatgtggag ttaccagcca caaatgggac ttgcggctgg agctgcccaa    26760

gactactcaa cccgaataaa ctacatgagc gcgggacccc acatgatatc ccgggtcaac    26820

ggaatccgcg cccaccgaaa ccgaattctc ttggaacagg cggctattac caccacacct    26880

cgtaataacc ttaatccccg tagttggccc gctgccctgg tgtaccagga aagtcccgct    26940

cccaccactg tggtacttcc cagagacgcc caggccgaag ttcagatgac taactcaggg    27000

gcgcagcttg cgggcggctt tcgtcacagg gtgcggtcgc ccgggcaggg tataactcac    27060

ctgacaatca gagggcgagg tattcagctc aacgacgagt cggtgagctc ctcgcttggt    27120

ctccgtccgg acgggacatt tcagatcggc ggcgccggcc gtccttcatt cacgcctcgt    27180

caggcaatcc taactctgca gacctcgtcc tctgagccgc gctctggagg cattggaact    27240

ctgcaattta ttgaggagtt tgtgccatcg gtctacttta accccttctc gggacctccc    27300

ggccactatc cggatcaatt tattcctaac tttgacgcgg taaaggactc ggcggacggc    27360

tacgactgaa tgttaagtgg agaggcagag caactgcgcc tgaaacacct ggtccactgt    27420

cgccgccaca agtgctttgc ccgcgactcc ggtgagtttt gctactttga attgcccgag    27480

gatcatatcg agggcccggc gcacggcgtc cggcttaccg cccagggaga gcttgcccgt    27540

agcctgattc gggagtttac ccagcgcccc ctgctagttg agcgggacag gggaccctgt    27600

gttctcactg tgatttgcaa ctgtcctaac cttggattac atcaagatct ttgttgccat    27660

ctctgtgctg agtataataa atacagaaat taaaatatac tggggctcct atcgccatcc    27720

tgtaaacgcc accgtcttca cccgcccaag caaaccaagg cgaaccttac ctggtacttt    27780

taacatctct ccctctgtga tttacaacag tttcaaccca gacggagtga gtctacgaga    27840

gaacctctcc gagctcagct actccatcag aaaaaacacc accctcctta cctgccggga    27900

acgtacgagt gcgtcaccgg ccgctgcacc acacctaccg cctgaccgta aaccagactt    27960

tttccggaca gacctcaata actctgttta ccagaacagg aggtgagctt agaaaaccct    28020

tagggtatta ggccaaaggc gcagctactg tggggtttat gaacaattca agcaactcta    28080

cgggctattc taattcaggt ttctctagaa atggacggaa ttattacaga gcagcgcctg    28140

ctagaaagac gcagggcagc ggccgagcaa cagcgcatga atcaagagct ccaagacatg    28200

gttaacttgc accagtgcaa aaggggtatc ttttgtctgg taaagcaggc caaagtcacc    28260

tacgacagta ataccaccgg acaccgcctt agctacaagt tgccaaccaa gcgtcagaaa    28320

ttggtggtca tggtgggaga aaagcccatt accataactc agcactcggt agaaaccgaa    28380

ggctgcattc actcaccttg tcaaggacct gaggatctct gcacccttat taagaccctg    28440

tgcggtctca aagatcttat tccctttaac taataaaaaa aaataataaa gcatcactta    28500

cttaaaatca gttagcaaat ttctgtccag tttattcagc agcacctcct tgccctcctc    28560

ccagctctgg tattgcagct tcctcctggc tgcaaacttt ctccacaatc taaatggaat    28620

gtcagtttcc tcctgttcct gtccatccgc acccactatc ttcatgaagc gcgcaagacc    28680

gtctgaagat accttcaacc ccgtgtatcc atatgacacg gaaaccggtc ctccaactgt    28740

gccttttctt actcctccct ttgtatcccc caatgggttt caagagagtc cccctggagt    28800

tcttacttta aaatgtttaa ccccactaac aaccacaggc ggatctctac agctaaaagt    28860

gggaggggga cttacagtgg atgacactga tggtacctta caagaaaaca tacgtgctac    28920

agcacccatt actaaaaata atcactctgt agaactatcc attggaaatg gattagaaac    28980

tcaaaacaat aaactatgtg ccaaattggg aaatgggtta aaatttaaca acggtgacat    29040

ttgtataaag gatagtatta acaccttatg gactggaata aaccctccac ctaactgtca    29100

aattgtggaa aacactaata caaatgatgg caaacttact ttagtattag taaaaaacgg    29160

agggcttgtt aatggctacg tgtctctagt tggtgtatca gacactgtga accaaatgtt    29220

cacacaaaag acagcaaaca tccaattaag attatatttt gactcttctg gaaatctatt    29280

aactgatgaa tcagacttaa aaattccact taaaaataaa tcttctacag cgaccagtga    29340

aactgtagcc agcagcaaag cctttatgcc aagtactaca gcttatccct tcaacaccac    29400

tactagggat agtgaaaact acattcatgg aatatgttac tacatgacta gttatgatag    29460

aagtctattt cccttgaaca tttctataat gctaaacagc cgtatgattt cttccaatgt    29520

tgcctatgcc atacaatttg aatggaatct aaatgcaagt gaatctccag aaagcaacat    29580

agctacgctg accacatccc cctttttctt ttcttacatt acagaagacg acaactaaaa    29640

tgcccaagaa taaagaatcg tttgtgttat gtttcaacgt gtttattttt caattgcaga    29700

aaatttcaag tcatttttca ttcagtagta tagccccacc accacatagc ttatacagat    29760

caccgtacct taatcaaact cacagaaccc tagtattcaa cctgccacct ccctcccaac    29820

acacagagta cacagtcctt tctccccggc tggccttaaa aagcatcata tcatgggtaa    29880

cagacatatt cttaggtgtt atattccaca cggtttcctg tcgagccaaa cgctcatcag    29940

tgatattaat aaactccccg ggcagctcac ttaagttcat gtcgctgtcc agctgctgag    30000

ccacaggctg ctgtccaact tgcggttgct taacgggcgg cgaaggagaa gtccacgcct    30060

acatgggggt agagtcataa tcgtgcatca ggatagggcg gtggtgctgc agcagcgcgc    30120

gaataaactg ctgccgccgc cgctccgtcc tgcaggaata caacatggca gtggtctcct    30180

cagcgatgat tcgcaccgcc cgcagcataa ggcgccttgt cctccgggca cagcagcgca    30240

ccctgatctc acttaaatca gcacagtaac tgcagcacag caccacaata ttgttcaaaa    30300

tcccacagtg caaggcgctg tatccaaagc tcatggcggg gaccacagaa cccacgtggc    30360

catcatacca caagcgcagg tagattaagt ggcgacccct cataaacacg ctggacataa    30420

acattacctc ttttggcatg ttgtaattca ccacctcccg gtaccatata aacctctgat    30480

taaacatggc gccatccacc accatcctaa accagctggc caaaacctgc ccgccggcta    30540

tacactgcag ggaaccggga ctggaacaat gacagtggag agcccaggac tcgtaaccat    30600

ggatcatcat gctcgtcatg atatcaatgt tggcacaaca caggcacacg tgcatacact    30660

tcctcaggat tacaagctcc tcccgcgtta gaaccatatc ccagggaaca acccattcct    30720

gaatcagcgt aaatcccaca ctgcagggaa gacctcgcac gtaactcacg ttgtgcattg    30780

tcaaagtgtt acattcgggc agcagcggat gatcctccag tatggtagcg cgggtttctg    30840

tctcaaaagg aggtagacga tccctactgt acggagtgcg ccgagacaac cgagatcgtg    30900

ttggtcgtag tgtcatgcca aatggaacgc cggacgtagt catatttcct gaagcaaaac    30960

caggtgcggg cgtgacaaac agatctgcgt ctccggtctc gccgcttaga tcgctctgtg    31020

tagtagttgt agtatatcca ctctctcaaa gcatccaggc gccccctggc ttcgggttct    31080

atgtaaactc cttcatgcgc cgctgccctg ataacatcca ccaccgcaga ataagccaca    31140

cccagccaac ctacacattc gttctgcgag tcacacacgg gaggagcggg aagagctgga    31200

agaaccatgt tttttttttt attccaaaag attatccaaa acctcaaaat gaagatctat    31260

taagtgaacg cgctcccctc cggtggcgtg gtcaaactct acagccaaag aacagataat    31320

ggcatttgta agatgttgca caatggcttc caaaaggcaa acggccctca cgtccaagtg    31380

gacgtaaagg ctaaaccctt cagggtgaat ctcctctata aacattccag caccttcaac    31440

catgcccaaa taattctcat ctcgccacct tctcaatata tctctaagca aatcccgaat    31500

attaagtccg gccattgtaa aaatctgctc cagagcgccc tccaccttca gcctcaagca    31560

gcgaatcatg attgcaaaaa ttcaggttcc tcacagacct gtataagatt caaaagcgga    31620

acattaacaa aaataccgcg atcccgtagg tcccttcgca gggccagctg aacataatcg    31680

tgcaggtctg cacggaccag cgcggccact tccccgccag gaaccttgac aaaagaaccc    31740

acactgatta tgacacgcat actcggagct atgctaacca gcgtagcccc gatgtaagct    31800

ttgttgcatg ggcggcgata taaaatgcaa ggtgctgctc aaaaaatcag gcaaagcctc    31860

gcgcaaaaaa gaaagcacat cgtagtcatg ctcatgcaga taaaggcagg taagctccgg    31920

aaccaccaca gaaaaagaca ccatttttct ctcaaacatg tctgcgggtt tctgcataaa    31980

cacaaaataa aataacaaaa aaacatttaa acattagaag cctgtcttac aacaggaaaa    32040

acaaccctta taagcataag acggactacg gccatgccgg cgtgaccgta aaaaaactgg    32100

tcaccgtgat taaaaagcac caccgacagc tcctcggtca tgtccggagt cataatgtaa    32160

gactcggtaa acacatcagg ttgattcatc ggtcagtgct aaaaagcgac cgaaatagcc    32220

cgggggaata catacccgca ggcgtagaga caacattaca gcccccatag gaggtataac    32280

aaaattaata ggagagaaaa acacataaac acctgaaaaa ccctcctgcc taggcaaaat    32340

agcaccctcc cgctccagaa caacatacag cgcttcacag cggcagccta acagtcagcc    32400

ttaccagtaa aaaagaaaac ctattaaaaa aacaccactc gacacggcac cagctcaatc    32460

agtcacagtg taaaaaaggg ccaagtgcag agcgagtata tataggacta aaaaatgacg    32520

taacggttaa agtccacaaa aaacacccag aaaaccgcac gcgaacctac gcccagaaac    32580

gaaagccaaa aaacccacaa cttcctcaaa tcgtcacttc cgttttccca cgttacgtaa    32640

cttcccattt taagaaaact acaattccca acacatacaa gttactccgc cctaaaacct    32700

acgtcacccg ccccgttccc acgccccgcg ccacgtcaca aactccaccc cctcattatc    32760

atattggctt caatccaaaa taaggtatat tattgatgat gttaat                   32806


<210>  12
<211>  15
<212>  PRT
<213>  Plasmodium vivax

<400>  12

Asp Tyr Asp Val Val Tyr Leu Lys Pro Leu Ala Gly Met Tyr Lys 
1               5                   10                  15  


<210>  13
<211>  21
<212>  PRT
<213>  Plasmodium falciparum

<400>  13

Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe 
1               5                   10                  15      


Asn Val Val Asn Ser 
            20      


<210>  14
<211>  20
<212>  PRT
<213>  Plasmodium falciparum

<400>  14

Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe Asn 
1               5                   10                  15      


Val Val Asn Ser 
            20  


<210>  15
<211>  19
<212>  PRT
<213>  Plasmodium falciparum

<400>  15

Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe Asn Val 
1               5                   10                  15      


Val Asn Ser 
            


<210>  16
<211>  20
<212>  PRT
<213>  Plasmodium falciparum

<400>  16

Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe 
1               5                   10                  15      


Asn Val Val Asn 
            20  


<210>  17
<211>  19
<212>  PRT
<213>  Plasmodium falciparum

<400>  17

Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe 
1               5                   10                  15      


Asn Val Val 
            


<210>  18
<211>  18
<212>  PRT
<213>  Plasmodium falciparum

<400>  18

Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe 
1               5                   10                  15      


Asn Val 
        


<210>  19
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  19

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  20
<211>  21
<212>  PRT
<213>  Clostridium tetani

<400>  20

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  21
<211>  14
<212>  PRT
<213>  Clostridium tetani

<400>  21

Thr Lys Ile Tyr Ser Tyr Phe Pro Ser Val Ile Ser Lys Val 
1               5                   10                  


<210>  22
<211>  15
<212>  PRT
<213>  Clostridium tetani

<400>  22

Val Arg Asp Ile Ile Asp Asp Phe Thr Asn Glu Ser Ser Gln Lys 
1               5                   10                  15  


<210>  23
<211>  14
<212>  PRT
<213>  Clostridium tetani

<400>  23

Val Ser Thr Ile Val Pro Tyr Ile Gly Pro Ala Leu Asn Ile 
1               5                   10                  


<210>  24
<211>  14
<212>  PRT
<213>  Clostridium tetani

<400>  24

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  


<210>  25
<211>  21
<212>  PRT
<213>  Clostridium tetani

<400>  25

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  26
<211>  13
<212>  PRT
<213>  Influenza A virus

<400>  26

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


<210>  27
<211>  15
<212>  PRT
<213>  Enterovirus 71

<400>  27

Ile Glu Thr Arg Cys Val Leu Asn Ser His Ser Thr Ala Glu Thr 
1               5                   10                  15  


<210>  28
<211>  15
<212>  PRT
<213>  Enterovirus 71

<400>  28

Glu Val Val Pro Gln Leu Leu Gln Tyr Met Phe Val Pro Pro Gly 
1               5                   10                  15  


<210>  29
<211>  15
<212>  PRT
<213>  Enterovirus 71

<400>  29

Leu Val Val Arg Ile Tyr Met Arg Met Lys His Val Arg Ala Trp 
1               5                   10                  15  


<210>  30
<211>  17
<212>  PRT
<213>  EBV

<400>  30

Tyr Leu Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu 
1               5                   10                  15      


Leu 
    


<210>  31
<211>  20
<212>  PRT
<213>  Human immunodeficiency virus

<400>  31

Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala 
1               5                   10                  15      


Ile Ser Pro Arg 
            20  


<210>  32
<211>  20
<212>  PRT
<213>  Human immunodeficiency virus

<400>  32

Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly 
1               5                   10                  15      


Gln Met Arg Glu 
            20  


<210>  33
<211>  20
<212>  PRT
<213>  Human immunodeficiency virus

<400>  33

Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
1               5                   10                  15      


Pro Val Gly Glu 
            20  


<210>  34
<211>  15
<212>  PRT
<213>  Human immunodeficiency virus

<400>  34

Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met Tyr 
1               5                   10                  15  


<210>  35
<211>  20
<212>  PRT
<213>  Human immunodeficiency virus

<400>  35

Asn Lys Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg 
1               5                   10                  15      


Gln Gly Pro Lys 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Human immunodeficiency virus

<400>  36

Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala 
1               5                   10                  15      


Glu Gln Ala Ser 
            20  


<210>  37
<211>  20
<212>  PRT
<213>  Human immunodeficiency virus

<400>  37

Tyr Lys Thr Leu Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp 
1               5                   10                  15      


Met Thr Glu Thr 
            20  


<210>  38
<211>  20
<212>  PRT
<213>  Human immunodeficiency virus

<400>  38

Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
1               5                   10                  15      


Leu Gly Pro Ala 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Human immunodeficiency virus

<400>  39

Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala Thr Leu Glu Glu Met 
1               5                   10                  15      


Met Thr Ala Cys 
            20  


<210>  40
<211>  25
<212>  PRT
<213>  Human adenovirus type 5

<400>  40

Val Pro Phe His Ile Gln Val Pro Gln Lys Phe Phe Ala Ile Lys Asn 
1               5                   10                  15      


Leu Leu Leu Leu Pro Gly Ser Tyr Thr 
            20                  25  


<210>  41
<211>  25
<212>  PRT
<213>  Human adenovirus type 5

<400>  41

Val Thr Thr Asp Arg Ser Gln Arg Leu Thr Leu Arg Phe Ile Pro Val 
1               5                   10                  15      


Asp Arg Glu Asp Thr Ala Tyr Ser Tyr 
            20                  25  


<210>  42
<211>  20
<212>  PRT
<213>  Human adenovirus type 5

<400>  42

Gly Gln Gln Ser Met Pro Asn Arg Pro Asn Tyr Ile Ala Phe Arg Asp 
1               5                   10                  15      


Asn Phe Ile Gly 
            20  


<210>  43
<211>  28
<212>  PRT
<213>  Human adenovirus type 5

<400>  43

Glu Val Asp Pro Met Asp Glu Pro Thr Leu Leu Tyr Val Leu Phe Glu 
1               5                   10                  15      


Val Phe Asp Val Val Arg Val His Arg Pro His Arg 
            20                  25              


