<110>    GREEN CROSS CORPORATION
         Mogam Institute for Biomedical Research

<120>    Antibodies specific for coronavirus spike protein and uses
         thereof

<130>    OPA21321

<150>    KR 10-2020-0148064
<151>    2020-11-06

<150>    KR 10-2021-0042796
<151>    2021-04-01

<160>    169

<170>    KoPatentIn 3.0

<210>    1
<211>    753
<212>    DNA
<213>    Unknown

<220>
<223>    SARS Corona virus 2 spike protein RBD domain


<400>    1
atgtttgtgt ttctggttct gctgcccctg gtgtcctcta gagtgcagcc tacagagtcc         60

atcgtgcggt tccccaacat caccaatctg tgccctttcg gcgaggtgtt caacgccaca        120

agatttgcca gcgtgtacgc ctggaaccgg aagagaatca gcaactgcgt ggccgactac        180

agcgtgctgt acaatagcgc cagcttcagc accttcaagt gctacggcgt gtcccctacc        240

aagctgaacg acctgtgctt caccaatgtg tacgccgaca gcttcgtgat cagaggcgac        300

gaagttcggc agatcgctcc tggacagaca ggcaagatcg ccgattacaa ctacaagctg        360

cccgacgact tcaccggctg cgtgatcgcc tggaatagca acaacctgga cagcaaagtc        420

ggcggcaact acaactacct gtaccggctg ttccggaagt ccaacctgaa gcctttcgag        480

cgggacatca gcaccgagat ctatcaggcc ggcagcaccc cttgtaatgg cgtggaaggc        540

ttcaactgct acttcccact gcagtcctac ggcttccagc ctacaaacgg cgtgggctac        600

cagccttata gagtggtggt gctgagcttc gaactgctgc atgcccctgc taccgtgtgc        660

ggccctaaga agtctaccaa cctggtcaag aacaaatgcg tgaacttcgg cggcctggtg        720

cctagaggat ctcaccacca tcaccatcac taa                                     753


<210>    2
<211>    250
<212>    PRT
<213>    Unknown

<220>
<223>    SARS Corona virus 2 spike protein RBD domain


<400>    2
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Arg Val Gln
  1               5                  10                  15 

Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro
             20                  25                  30 

Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp
         35                  40                  45 

Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr
     50                  55                  60 

Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr
 65                  70                  75                  80 

Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val
                 85                  90                  95 

Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys
            100                 105                 110 

Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val
        115                 120                 125 

Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr
    130                 135                 140 

Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu
145                 150                 155                 160 

Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn
                165                 170                 175 

Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe
            180                 185                 190 

Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu
        195                 200                 205 

Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys
    210                 215                 220 

Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly Gly Leu Val
225                 230                 235                 240 

Pro Arg Gly Ser His His His His His His
                245                 250


<210>    3
<211>    1620
<212>    DNA
<213>    Unknown

<220>
<223>    SARS Corona virus 2 spike protein RBD-SD1-Fc


<400>    3
atgcggccta cttgggcctg gtggctgttc ctggtgctgc tgctagctct gtgggcaccc         60

gctagagggc gggtgcagcc tacagagagc atcgtgcgat ttccaaacat taccaacctc        120

tgccccttcg gcgaggtgtt taacgccaca agatttgcct ccgtttacgc ctggaataga        180

aagagaatca gcaattgtgt ggccgactac tccgtgctgt ataacagcgc ctctttcagc        240

accttcaagt gctacggcgt ttccccaaca aagctgaatg acctgtgctt caccaacgtg        300

tacgccgact ccttcgtaat tagaggcgat gaggtgcggc agatcgcacc aggccagacc        360

ggtaagatcg ctgactacaa ctataagctg cctgatgatt ttacaggctg cgtgatcgcc        420

tggaactcta acaacctgga tagcaaggtg ggcggcaact acaactacct gtaccggctg        480

tttcgcaagt ctaacctgaa acctttcgag agagacatct ccacagagat ctaccaggcc        540

ggttctacac cttgtaacgg ggtggaaggc ttcaactgtt acttccctct gcaaagctac        600

ggcttccagc ctaccaatgg agtcggctac cagccatacc gggtggtcgt gctgtccttc        660

gagttactcc acgcccccgc caccgtctgc ggtcctaaga agtccaccaa tctggttaag        720

aacaaatgcg tgaacttcaa cttcaacggc ctgaccggga ccggcgtgct gaccgaaagc        780

aacaaaaagt tcctcccctt ccagcagttc ggccgtgata tcgctgacac cacagatgcc        840

gtcagagatc cacagaccct ggaaatcctg gatattacac cctgctccgg atccctggag        900

gtgctgttcc agggcccaac tcacacatcc ccaccgagcc cagcacctga actcctgggg        960

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc       1020

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac       1080

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac       1140

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc       1200

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc       1260

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccaaaccccc atcccgggat       1320

gagctgacca agaaccaggt cagcctgtcc tgcctggtca aaggcttcta tcccagcgac       1380

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacggtcccc       1440

gtgctggact ccgacggctc cttcaggctc gccagctatc tcaccgtgga caagagcagg       1500

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac       1560

acgcagaaga gcctctccct gtctccgggt aaacatcacc atcatcacca ccatcactag       1620

                                                                        1620


<210>    4
<211>    250
<212>    PRT
<213>    Unknown

<220>
<223>    SARS Corona virus 2 spike protein RBD-SD1-Fc


<400>    4
Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Arg Val Gln
  1               5                  10                  15 

Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro
             20                  25                  30 

Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp
         35                  40                  45 

Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr
     50                  55                  60 

Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr
 65                  70                  75                  80 

Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val
                 85                  90                  95 

Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys
            100                 105                 110 

Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val
        115                 120                 125 

Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr
    130                 135                 140 

Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu
145                 150                 155                 160 

Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn
                165                 170                 175 

Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe
            180                 185                 190 

Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu
        195                 200                 205 

Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys
    210                 215                 220 

Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly Gly Leu Val
225                 230                 235                 240 

Pro Arg Gly Ser His His His His His His
                245                 250


<210>    5
<211>    124
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 1


<400>    5
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Gln Lys Pro Gly Ser
  1               5                  10                  15 

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
             20                  25                  30 

Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Lys Ile Ile Pro Ile Leu Gly Ile Pro Asn Tyr Ala Gln Arg Phe
     50                  55                  60 

Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Gly Thr Ala Tyr
 65                  70                  75                  80 

Leu Asp Leu Ser Ser Leu Ser Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Ala Gly Gly Tyr Ser Gly Tyr Gly Ala His Tyr Tyr Met Asp
            100                 105                 110 

Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Ser
        115                 120                


<210>    6
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 2


<400>    6
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys
                 85                  90                  95 

Ala Lys Asp Leu Tyr Gly Gly Pro Gly Ser Ser Thr Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    7
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 3


<400>    7
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys
                 85                  90                  95 

Ala Lys Asp Leu Tyr Gly Gly Pro Gly Ser Ser Thr Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    8
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 4


<400>    8
Glu Asp Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Phe Tyr Cys
                 85                  90                  95 

Ala Lys Asp Leu Tyr Gly Gly Pro Gly Ser Ser Thr Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    9
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 5


<400>    9
Glu Asp Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Phe
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Ser Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Phe Tyr Cys
                 85                  90                  95 

Ala Lys Asp Leu Tyr Gly Gly Pro Gly Ser Ser Thr Phe Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    10
<211>    123
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 6


<400>    10
Gln Leu Gln Leu Gln Glu Ser Gly Gly Gly Trp Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Thr Cys Ala Thr Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Thr Trp Asn Ser Asp Ser Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asp Asn Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Val Lys Asp Ser Ala Tyr Arg Ile Leu Pro Tyr Trp Tyr Phe Asp Leu
            100                 105                 110 

Trp Gly Arg Gly Thr Thr Val Thr Val Ser Ser
        115                 120            


<210>    11
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 7


<400>    11
Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Ile Ser Cys Ala Ala Ser Gly Phe Ala Val Ser Asn Asn
             20                  25                  30 

Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Val Ile His Thr Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
     50                  55                  60 

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
 65                  70                  75                  80 

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                 85                  90                  95 

Arg Glu Gly Phe Gly Glu Leu Leu Gly Ser Asp Ala Phe Asp Ile Trp
            100                 105                 110 

Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120        


<210>    12
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 8


<400>    12
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Thr Phe
             20                  25                  30 

Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Tyr Ile Ser Pro Ser Gly Ser Ser Ile Tyr Asn Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Ser Tyr Tyr Gly Gly Ser Ala Phe Asp Ile Trp
            100                 105                 110 

Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120        


<210>    13
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 9


<400>    13
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Arg Thr Phe
             20                  25                  30 

Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Tyr Ile Ser Pro Ser Gly Ser Ser Ile Tyr Asn Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Ser Tyr Tyr Gly Gly Ser Ala Phe Asp Ile Trp
            100                 105                 110 

Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120        


<210>    14
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 10


<400>    14
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Ser Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Phe
             20                  25                  30 

Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Tyr Ile Ser Pro Ser Gly Ser Ser Ile Tyr Asn Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Ser Tyr Tyr Gly Gly Ser Ala Phe Asp Ile Trp
            100                 105                 110 

Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120        


<210>    15
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 11


<400>    15
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp His Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    16
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 12


<400>    16
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Ser Gly Asn Gly Gly Ser Thr Ser Tyr Ala Ala Ser Val
     50                  55                  60 

Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    17
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 13


<400>    17
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Gly Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Val Ile Ser Glu Asp Gly Ser Asp Glu Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    18
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 14


<400>    18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    19
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 15


<400>    19
Gln Val Gln Leu Val Glu Ser Gly Gly Thr Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
             20                  25                  30 

Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ser Val Ser Gly Arg Gly Asp Thr Thr His Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Arg Glu Asn Lys Leu Tyr
 65                  70                  75                  80 

Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    20
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 16


<400>    20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Ser Ser Ser Asp Asp Thr Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    21
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 17


<400>    21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Ser Ser Tyr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    22
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 18


<400>    22
Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Ser Ser Ser Asp Asp Thr Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    23
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 19


<400>    23
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    24
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 20


<400>    24
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr
             20                  25                  30 

Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Ala Ile Ser Ser Ser Asp Asp Thr Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    25
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 21


<400>    25
Gln Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    26
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 22


<400>    26
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ala Gln Ser Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    27
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 23


<400>    27
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    28
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 24


<400>    28
Glu Val Gln Leu Val Glu Ser Gly Gly Ala Met Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    29
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 25


<400>    29
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    30
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 26


<400>    30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    31
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 27


<400>    31
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    32
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 28


<400>    32
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    33
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 29


<400>    33
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    34
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 30


<400>    34
Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    35
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 31


<400>    35
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Glu Gly Ser Glu Lys Tyr Tyr Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    36
<211>    129
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 32


<400>    36
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
             20                  25                  30 

Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asp Ile Glu Lys Asp Gly Gly Glu Arg Asn Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Glu Gly Gly Tyr Tyr Tyr Gly Ser Gly Ser Tyr Tyr Lys Pro
            100                 105                 110 

Lys Val Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120                 125 

Ser
   


<210>    37
<211>    133
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 33


<400>    37
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
             20                  25                  30 

Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr Ser Val Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg His Gly Ile Tyr Cys Ser Gly Asp Asn Cys Tyr Tyr Phe Ala
            100                 105                 110 

Pro Thr Leu Ser Ser His Ala Phe Asp Ile Trp Gly Gln Gly Thr Met
        115                 120                 125 

Val Thr Val Ser Ser
    130            


<210>    38
<211>    125
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 34


<400>    38
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ser Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Ile Ile Pro Gly Asp Gly Tyr Asn Tyr Pro Gly Ala Ser Asp Phe
            100                 105                 110 

Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125


<210>    39
<211>    125
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 35


<400>    39
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ser Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Ile Ile Pro Gly Asp Gly Tyr Asn Tyr Pro Gly Ala Ser Asp Phe
            100                 105                 110 

Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125


<210>    40
<211>    125
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 36


<400>    40
Gln Val Thr Leu Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ser Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Ile Ile Pro Gly Asp Gly Tyr Asn Tyr Pro Gly Ala Ser Asp Phe
            100                 105                 110 

Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125


<210>    41
<211>    125
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 37


<400>    41
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
             20                  25                  30 

Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ser Ser Trp Asn Ser Gly Thr Ile Gly Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                 85                  90                  95 

Ala Ile Ile Pro Gly Asp Gly Tyr Asn Tyr Pro Gly Ala Ser Asp Phe
            100                 105                 110 

Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125


<210>    42
<211>    120
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 38


<400>    42
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
  1               5                  10                  15 

Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Tyr
             20                  25                  30 

Tyr Thr His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
         35                  40                  45 

Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ile Tyr Ala Gln Lys Phe
     50                  55                  60 

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr
 65                  70                  75                  80 

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Leu Pro Arg Asp Gly Val His Ala Ser Asp Ile Trp Gly Gln
            100                 105                 110 

Gly Thr Thr Val Thr Val Ser Ser
        115                 120


<210>    43
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 39


<400>    43
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Leu Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Asp Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Pro Pro Tyr Ser Phe Asp Ser Met Ser Glu Ser Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120        


<210>    44
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 40


<400>    44
Gln Val Gln Leu Gln Asp Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
  1               5                  10                  15 

Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
             20                  25                  30 

Asp Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Asp Ile Tyr Asn Ser Gly Ser Thr Lys Tyr Asn Pro Ser Leu Lys
     50                  55                  60 

Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu Ser Leu
 65                  70                  75                  80 

Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                 85                  90                  95 

Arg Arg Gly Leu Gly Asn Tyr Asp Ile Leu Thr Gly Tyr Phe Glu Asn
            100                 105                 110 

Ala Phe Asp Ile Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125 




<210>    45
<211>    127
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 41


<400>    45
Glu Thr Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Tyr Ile Ser Ser Ser Thr Ser Thr Ile Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Thr Arg Leu Thr Gln Leu Ala Met Ile Gly Arg Gly Gly Asn
            100                 105                 110 

Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120                 125 




<210>    46
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 1


<400>    46
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Ser Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    47
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 2


<400>    47
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
             20                  25                  30 

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu
                 85                  90                  95 

Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg
            100                 105            


<210>    48
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 3


<400>    48
Ala Ile Trp Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr
             20                  25                  30 

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Asn Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    49
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 4


<400>    49
Asp Ile Val Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Ile Tyr
             20                  25                  30 

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Phe Ser Tyr Pro Ile
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    50
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 5


<400>    50
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Glu Asp Ile Thr Asp Tyr
             20                  25                  30 

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Asp Ala Ser Ile Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Leu Pro Leu
                 85                  90                  95 

Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg
            100                 105        


<210>    51
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 6


<400>    51
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Asn Tyr
             20                  25                  30 

Leu Asn Trp Tyr Gln Gln Ile Pro Gly Lys Ala Pro Lys Leu Leu Met
         35                  40                  45 

Tyr Ala Ala Thr Arg Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Tyr Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Gly Ser Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105            


<210>    52
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 7


<400>    52
Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
             20                  25                  30 

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro His
                 85                  90                  95 

Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg
            100                 105            


<210>    53
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 8


<400>    53
Ser Tyr Glu Leu Thr Gln Pro Ser Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    54
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 9


<400>    54
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Arg Asn
             20                  25                  30 

Ile Val Asn Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Thr Asn Ser His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Ser Ala Ala Ser Leu Ala Ile Ser Gly Leu Gln
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Thr Leu
                 85                  90                  95 

Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    55
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 10


<400>    55
Gln Ser Val Pro Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Asn Gly Arg Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    56
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 11


<400>    56
Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
  1               5                  10                  15 

Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
             20                  25                  30 

Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
         35                  40                  45 

Met Ile Tyr Asp Val Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Cys Ser Tyr Ala Gly Ser
                 85                  90                  95 

Tyr Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    57
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 12


<400>    57
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    58
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 13


<400>    58
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Glu Leu Thr Val Leu Gly
            100                 105                 110 




<210>    59
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 14


<400>    59
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    60
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 15


<400>    60
Gln Ala Gly Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Met Ser Cys Thr Gly Thr Thr Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu
 65                  70                  75                  80 

Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser
                 85                  90                  95 

Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    61
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 16


<400>    61
Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    62
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 17


<400>    62
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    63
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 18


<400>    63
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Asp Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Glu Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    64
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 19


<400>    64
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Phe Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Asp Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Asp Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Glu Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Asp Leu Gly
            100                 105                 110 




<210>    65
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 20


<400>    65
Gln Ser Ala Leu Ile Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln
  1               5                  10                  15 

Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asn Val Gly Val Tyr
             20                  25                  30 

Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
         35                  40                  45 

Ile Ile Tyr Asp Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Asn Thr Gly Ser Leu Thr Ile Ser Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Ser Cys Ser Tyr Ala Gly Ser
                 85                  90                  95 

Tyr Thr Trp Val Phe Gly Pro Gly Thr Lys Val Thr Val Leu Ser
            100                 105                 110 




<210>    66
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 21


<400>    66
Gln Thr Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 

Gly
   


<210>    67
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 22


<400>    67
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Tyr Asn
                 85                  90                  95 

Leu Ser Gly Tyr Val Ser Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    68
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 23


<400>    68
Thr Tyr Glu Leu Ser Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Asp
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Gly Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser
                 85                  90                  95 

Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    69
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 24


<400>    69
Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Thr Cys Thr Gly Ser Gly Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Ala Pro Asp Arg Val
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Arg Thr Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    70
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 25


<400>    70
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    71
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 26


<400>    71
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Asn
                 85                  90                  95 

Leu Ser Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    72
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 27


<400>    72
Ser Tyr Glu Leu Met Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Arg Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Asp Leu Gly
            100                 105                 110 




<210>    73
<211>    109
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 28


<400>    73
Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Thr Asn Asp
             20                  25                  30 

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Thr Pro Pro
                 85                  90                  95 

Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                


<210>    74
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 29


<400>    74
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Ser Thr Val Phe Gly Gly Gly Thr Glu Leu Thr Val Leu
            100                 105                 110 

Gly
   


<210>    75
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 30


<400>    75
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Ser
                 85                  90                  95 

Leu Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    76
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 31


<400>    76
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln Gln Val Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser
                 85                  90                  95 

Leu Ser Gly Ser Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu
            100                 105                 110 

Gly
   


<210>    77
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 32


<400>    77
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln
  1               5                  10                  15 

Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly
             20                  25                  30 

Tyr Asp Val His Trp Tyr Gln His Leu Pro Gly Thr Ala Pro Lys Leu
         35                  40                  45 

Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Ser
                 85                  90                  95 

Leu Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    78
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 33


<400>    78
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
             20                  25                  30 

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    79
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 34


<400>    79
Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Val Ile Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser His
             20                  25                  30 

Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asn Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
 65                  70                  75                  80 

Ser Ala Asp Glu Ala Asp Tyr Ser Cys Ala Ala Trp Asp Asp Ser Leu
                 85                  90                  95 

Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    80
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 35


<400>    80
Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln
  1               5                  10                  15 

Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr
             20                  25                  30 

Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu
         35                  40                  45 

Met Ile Tyr Asp Val Gly Gln Arg Pro Ser Gly Val Ser Asn Arg Phe
     50                  55                  60 

Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu
 65                  70                  75                  80 

Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser
                 85                  90                  95 

Ser Ser Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    81
<211>    109
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 36


<400>    81
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
  1               5                  10                  15 

Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
         35                  40                  45 

Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
     50                  55                  60 

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His
                 85                  90                  95 

Val Val Phe Gly Gly Gly Thr Gln Leu Ile Ile Leu Gly
            100                 105                


<210>    82
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 37


<400>    82
Arg Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
  1               5                  10                  15 

Arg Ala Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
             20                  25                  30 

Thr Val Asn Trp Tyr Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile His Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln
 65                  70                  75                  80 

Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
                 85                  90                  95 

Asp Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    83
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 38


<400>    83
Gln Thr Val Val Thr Gln Glu Pro Ser Val Ser Ala Ala Pro Glu Gln
  1               5                  10                  15 

Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
             20                  25                  30 

Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
 65                  70                  75                  80 

Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu
                 85                  90                  95 

Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly
            100                 105                 110 




<210>    84
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 39


<400>    84
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
  1               5                  10                  15 

Lys Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Val Glu Asn Asn
             20                  25                  30 

Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Glu Asn Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
 65                  70                  75                  80 

Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Val Trp Asp Asp Ser Leu
                 85                  90                  95 

Asn His Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    85
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 40


<400>    85
Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
             20                  25                  30 

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Arg
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg
            100                 105            


<210>    86
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone 41


<400>    86
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Lys
  1               5                  10                  15 

Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val
             20                  25                  30 

His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr
         35                  40                  45 

Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
     50                  55                  60 

Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly
 65                  70                  75                  80 

Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Val Val
                 85                  90                  95 

Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105        


<210>    87
<211>    121
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M1


<400>    87
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
             20                  25                  30 

Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Leu Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Asp Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Pro Pro Tyr Ser Phe Asp Ser Met Ser Glu Ser Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Leu Val Thr Val Ser
        115                 120    


<210>    88
<211>    115
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M2


<400>    88
Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala
  1               5                  10                  15 

Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr
             20                  25                  30 

Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile
         35                  40                  45 

Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe
     50                  55                  60 

Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr
 65                  70                  75                  80 

Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Asn Glu Asp Gly Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr
            100                 105                 110 

Val Ser Ser
        115


<210>    89
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M3


<400>    89
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
             20                  25                  30 

Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Asp Trp Val
         35                  40                  45 

Ala Ser Ile Ser Ser Ser Gly Gly Thr Tyr Tyr Pro Asp Ser Val Lys
     50                  55                  60 

Gly Arg Phe Thr Ile Ser Arg Asp Ile Ala Arg Asn Ile Leu Tyr Leu
 65                  70                  75                  80 

Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Val
                 85                  90                  95 

Arg Gly Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser
            100                 105                 110 




<210>    90
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4


<400>    90
Asp Val Met Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Val Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Leu Thr Val Ser Ala
        115        


<210>    91
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5


<400>    91
Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Leu Thr Val Ser Ser
        115        


<210>    92
<211>    111
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M1


<400>    92
Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln
  1               5                  10                  15 

Lys Val Thr Ile Ser Cys Ser Gly Ser Gly Ser Asn Val Glu Asn Asn
             20                  25                  30 

Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
         35                  40                  45 

Ile Tyr Glu Asn Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser
     50                  55                  60 

Gly Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln
 65                  70                  75                  80 

Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Val Trp Asp Asp Ser Leu
                 85                  90                  95 

Asn His Val Ile Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110 




<210>    93
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M2


<400>    93
Asp Val Val Val Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
  1               5                  10                  15 

Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Ala
             20                  25                  30 

Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro
         35                  40                  45 

Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala
     50                  55                  60 

Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His
 65                  70                  75                  80 

Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn
                 85                  90                  95 

Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105                 110 




<210>    94
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M3


<400>    94
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser
 65                  70                  75                  80 

Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Thr Arg Tyr Ser Asn
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105            


<210>    95
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4


<400>    95
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Val Gln Ala
 65                  70                  75                  80 

Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105            


<210>    96
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5


<400>    96
Asp Val Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Gln Ala
 65                  70                  75                  80 

Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys
            100                 105        


<210>    97
<211>    119
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 5E9


<400>    97
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Tyr
             20                  25                  30 

Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val
         35                  40                  45 

Ser Leu Ile Ser Ser Gly Gly Ser Asn Thr Trp Tyr Asp Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Glu Lys Tyr Pro Tyr Ser Asp Cys Asp Tyr Trp Gly Gln Gly
            100                 105                 110 

Thr Leu Val Thr Val Ser Ser
        115                


<210>    98
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 6D9


<400>    98
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr
             20                  25                  30 

Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val
         35                  40                  45 

Ser Leu Ile Ser Gly Asp Ser Gly Asn Thr Trp Tyr Asp Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Tyr Arg Gly Thr Thr Lys Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    99
<211>    112
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone 6H10


<400>    99
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr
             20                  25                  30 

Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val
         35                  40                  45 

Ser Leu Ile Ser Tyr Asp Gly Ser Ser Thr Trp Tyr Asp Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Lys Pro Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
            100                 105                 110 




<210>    100
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4-1 (H original)


<400>    100
Asp Val Met Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Val Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Leu Thr Val Ser Ala
        115        


<210>    101
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4-2 (H original)


<400>    101
Asp Val Met Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Val Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Leu Thr Val Ser Ala
        115        


<210>    102
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4-3 (H1)


<400>    102
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    103
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4-4 (H1)


<400>    103
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    104
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4-5 (H1)


<400>    104
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    105
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4-6 (H2)


<400>    105
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    106
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4-7 (H2)


<400>    106
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    107
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M4-8 (H2)


<400>    107
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    108
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5-1 (H original)


<400>    108
Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Leu Thr Val Ser Ser
        115        


<210>    109
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5-2 (H original)


<400>    109
Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr
            100                 105                 110 

Leu Thr Val Ser Ser
        115        


<210>    110
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5-3 (H1)


<400>    110
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    111
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5-4 (H1)


<400>    111
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    112
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5-5 (H1)


<400>    112
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    113
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5-6 (H2)


<400>    113
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    114
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5-7 (H2)


<400>    114
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    115
<211>    117
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    heavy chain variable region of clone M5-8 (H2)


<400>    115
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Arg
             20                  25                  30 

Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Ile Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Pro Asn Asp Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
            100                 105                 110 

Val Thr Val Ser Ser
        115        


<210>    116
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4-1 (hM4-k2)


<400>    116
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    117
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4-2 (hM4-k3)


<400>    117
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Asp Arg Val Ser Ile Ser Cys Arg Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    118
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4-3 (4k original)


<400>    118
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Val Gln Ala
 65                  70                  75                  80 

Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105            


<210>    119
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4-4 (hM4-k2)


<400>    119
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    120
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4-5 (hM4-k3)


<400>    120
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Asp Arg Val Ser Ile Ser Cys Arg Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    121
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4-6 (4k original)


<400>    121
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Asn Ser Val Gln Ala
 65                  70                  75                  80 

Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105            


<210>    122
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4-7 (hM4-k2)


<400>    122
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    123
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M4-8 (hM4-k3)


<400>    123
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Asp Arg Val Ser Ile Ser Cys Arg Ala Ser Gln Asp Val Ser Thr Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    124
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5-1 (hM5-k1)


<400>    124
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    125
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5-2 (hM5-k2)


<400>    125
Asp Val Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    126
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5-3 (5k original)


<400>    126
Asp Val Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Gln Ala
 65                  70                  75                  80 

Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys
            100                 105        


<210>    127
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5-4 (hM5-k1)


<400>    127
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    128
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5-5 (hM5-k2)


<400>    128
Asp Val Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    129
<211>    107
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5-6 (5k original)


<400>    129
Asp Val Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Gln Ala
 65                  70                  75                  80 

Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys
            100                 105        


<210>    130
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5-7 (hM5-k1)


<400>    130
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    131
<211>    108
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    light chain variable region of clone M5-8 (hM5-k2)


<400>    131
Asp Val Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Asn Asp
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
         35                  40                  45 

Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
 65                  70                  75                  80 

Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Tyr Ser Ala Pro Tyr
                 85                  90                  95 

Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105            


<210>    132
<211>    408
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    H1


<400>    132
tgctgtgggt gagtggtacc tgtggggaag tccaactggt tgagtccggt ggaggactcg         60

tcaagcccgg tgggtctctc cgactgagtt gtgcggcatc tggcttcact ttctccagtc        120

gaggtatgtc ttgggttcga caagcgccag ggaaagggct ggaatgggtc agtaccatat        180

ctttcgggga catatatacc tattacccgg attctgtgaa aggaaggttt actataagtc        240

gggataatgc aaagaactcc ttgtatcttc aaatgaactc cctgcgagct gaggatactg        300

cagtctacta ttgtgcccgg cccaatgacg ggtattttga ctactggggc caaggtactc        360

tggttacggt tagttcagcc tccaccaagg gcccatcggt cttccccc                     408


<210>    133
<211>    408
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    H2


<400>    133
tgctgtgggt gagtggtacc tgtggggaag tccaactggt tgagtccggt ggaggactcg         60

tcaagcccgg tgggtctctc aaactgagtt gtgcggcatc tggcttcact ttctccagtc        120

gaggtatgtc ttgggttcga caagcgccag ggaaagggct ggaatgggtc agtaccatat        180

ctttcgggga catatatacc tattacccgg attctgtgaa aggaaggttt actataagtc        240

gggataatgc aaagaactcc ttgtatcttc aaatgaactc cctgaaagct gaggatactg        300

cagtctacta ttgtgcccgg cccaatgacg ggtattttga ctactggggc caaggtactc        360

tggttacggt tagttcagcc tccaccaagg gcccatcggt cttccccc                     408


<210>    134
<211>    370
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hM4-k1


<400>    134
tgctgtgggt gagtggtacc tgtggggata tacagatgac ccagtctccg tctagtctga         60

gcgcgtccgt gggcgatcgg gttactatta cttgcaaggc cagccaggat gtatctacag        120

acgtagcctg gtatcagcaa aaaccaggca aagctcccaa actgcttata tattgggcga        180

gtacccgaca tacgggggtc ccgagcaggt ttagtggttc tgggtccggg acagacttta        240

ctttgaccat tagttccctg cagcccgagg actttgccac ttattactgt cagcagcact        300

atagcacgcc ttggactttc gggggaggta caaaagttga aatcaagcgt acggtggccg        360

ctccaagcgt                                                               370


<210>    135
<211>    370
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hM4-k2


<400>    135
tgctgtgggt gagtggtacc tgtggggata tagtgatgac tcaaagcccg gcgacgcttt         60

ccgtttctcc cggtgagcgg gcaaccttgt catgcaaagc atcccaggat gtttccacgg        120

acgtggcatg gtatcaacaa aagccaggtc aagcgccacg cctccttata tactgggcat        180

caactcgaca caccggggtg ccggacaggt tcagcggaag cgggagcggt acagacttca        240

ctctcaccat tagttcattg cagagcgagg actttgctgt ttactactgc caacaacact        300

atagcacgcc ctggacattc gggggcggaa cgaaagtgga gatcaagcgt acggtggccg        360

ctccaagcgt                                                               370


<210>    136
<211>    370
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hM4-k3


<400>    136
tgctgtgggt gagtggtacc tgtggggata tagtgatgac tcaaagcccg gcgacgcttt         60

ccgtttctcc cggtgaccgg gtaagcttgt catgcagagc atcccaggat gtttccacgg        120

acgtggcatg gtatcaacaa aagccaggtc aaagcccacg cctccttata tactgggcat        180

caactcgaca caccggggtg ccggacaggt tcagcggaag cgggagcggt acagacttca        240

ctctcaccat tagttcattg cagcccgagg actttgctgt ttactactgc caacaacact        300

atagcacgcc ctggacattc gggggcggaa cgaaagtgga gatcaagcgt acggtggccg        360

ctccaagcgt                                                               370


<210>    137
<211>    370
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hM5-k1


<400>    137
tgctgtgggt gagtggtacc tgtggggaca tacagatgac gcagtcaccg tcttcactct         60

ccgccagcgt aggtgaccgg gtcactatta cctgtaaagc ctcccaaagc gtttcaaatg        120

acgtcgcctg gtatcagcag aaaccgggaa aagcgcccaa attgcttata tactacgcca        180

gtaaccgata taccggtgtt ccatcacgct ttagcgggag cggcagtggt actgacttta        240

cattgacaat tagttccctt caacctgagg attttgcaac ttattactgc cagcagagtt        300

attctgcccc ctatacattc ggtgggggga cgaaggtgga gataaagcgt acggtggccg        360

ctccaagcgt                                                               370


<210>    138
<211>    370
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    hM5-k2


<400>    138
tgctgtgggt gagtggtacc tgtggggacg ttgtaatgac gcaatctccc gctaccttgt         60

ccgtctcacc aggtgagagg gcaaccctga gttgtaaagc aagtcagtcc gtgtcaaacg        120

atgtcgcctg gtatcaacag aagcccggcc aagctccccg attgcttatc tactacgcaa        180

gtaaccgcta tacaggcgtc ccggatcggt tcacggggag tggcagtggc acggatttca        240

ccctgacaat atcttctctc caaagtgagg actttgcggt gtactactgt cagcagtcat        300

actctgcccc atatactttt ggcggtggga ctaaggttga aattaaacgt acggtggccg        360

ctccaagcgt                                                               370


<210>    139
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-CDR1 of M4, M5, and M4-4


<400>    139
Ser Arg Gly Met Ser
  1               5


<210>    140
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-CDR2 of M4, M5, and M4-4


<400>    140
Thr Ile Ser Phe Gly Asp Ile Tyr Thr Tyr Tyr Pro Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    141
<211>    8
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-CDR3 of M4, M5, and M4-4


<400>    141
Pro Asn Asp Gly Tyr Phe Asp Tyr
  1               5            


<210>    142
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR1 of M4, and M4-4


<400>    142
Lys Ala Ser Gln Asp Val Ser Thr Asp Val Ala
  1               5                  10    


<210>    143
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR2 of M4, and M4-4


<400>    143
Trp Ala Ser Thr Arg His Thr
  1               5        


<210>    144
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR3 of M4, and M4-4


<400>    144
Gln Gln His Tyr Ser Thr Pro Trp Thr
  1               5                


<210>    145
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR1 of M5


<400>    145
Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala
  1               5                  10    


<210>    146
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR2 of M5


<400>    146
Tyr Ala Ser Asn Arg Tyr Thr
  1               5        


<210>    147
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-CDR3 of M5


<400>    147
Gln Gln Ser Tyr Ser Ala Pro Tyr Thr
  1               5                


<210>    148
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR1 of M4


<400>    148
Asp Val Met Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
             20                  25                  30


<210>    149
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR2 of M4, and M5


<400>    149
Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala
  1               5                  10                


<210>    150
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR3 of M4


<400>    150
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln
  1               5                  10                  15 

Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Val Arg
             20                  25                  30 




<210>    151
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR4 of M4


<400>    151
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ala
  1               5                  10    


<210>    152
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR1 of M5


<400>    152
Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
             20                  25                  30


<210>    153
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR3 of M5


<400>    153
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln
  1               5                  10                  15 

Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg
             20                  25                  30 




<210>    154
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR4 of M5


<400>    154
Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser
  1               5                  10    


<210>    155
<211>    30
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR1 of M4-4


<400>    155
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
             20                  25                  30


<210>    156
<211>    14
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR2 of M4-4


<400>    156
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
  1               5                  10                


<210>    157
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR3 of M4-4


<400>    157
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln
  1               5                  10                  15 

Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
             20                  25                  30 




<210>    158
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VH-FR4 of M4-4


<400>    158
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
  1               5                  10    


<210>    159
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR1 of M4


<400>    159
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Ser Ile Thr Cys
             20            


<210>    160
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR2 of M4, and M5


<400>    160
Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr
  1               5                  10                  15


<210>    161
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR3 of M4


<400>    161
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Tyr Thr
  1               5                  10                  15 

Leu Thr Ile Asn Ser Val Gln Ala Glu Asp Leu Ala Leu Tyr Tyr Cys
             20                  25                  30 




<210>    162
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR4 of M4


<400>    162
Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
  1               5                  10    


<210>    163
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR1 of M5


<400>    163
Asp Val Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys
             20            


<210>    164
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR3 of M5


<400>    164
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr
  1               5                  10                  15 

Leu Thr Ile Asn Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys
             20                  25                  30 




<210>    165
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR4 of M5


<400>    165
Phe Gly Gly Gly Thr Lys Leu Glu Met Lys
  1               5                  10


<210>    166
<211>    23
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR1 of M4-4


<400>    166
Asp Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Ala Thr Leu Ser Cys
             20            


<210>    167
<211>    15
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR2 of M4-4


<400>    167
Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr
  1               5                  10                  15


<210>    168
<211>    32
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR3 of M4-4


<400>    168
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
  1               5                  10                  15 

Leu Thr Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys
             20                  25                  30 




<210>    169
<211>    11
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    VL-FR4 of M4-4


<400>    169
Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
  1               5                  10    
