                               SEQUENCE LISTING

<110> SPECIFIC BIOLOGICS INC.
 
<120> GENE EDITING WITH A MODIFIED ENDONUCLEASE

<130> 61414-702.601

<140> PCT/IB2021/060236
<141> 2021-11-04

<150> 63/109,396
<151> 2020-11-04

<160> 67    

<170> PatentIn version 3.5

<210> 1
<211> 1675
<212> DNA
<213> Homo sapiens

<400> 1
attcctgaag ctgacagcat tcgggccgag atgtctcgct ccgtggcctt agctgtgctc       60

gcgctactct ctctttctgg cctggaggct atccagcgta ctccaaagat tcaggtttac      120

tcacgtcatc cagcagagaa tggaaagtca aatttcctga attgctatgt gtctgggttt      180

catccatccg acattgaagt tgacttactg aagaatggag agagaattga aaaagtggag      240

cattcagact tgtctttcag caaggactgg tctttctatc tcttgtacta cactgaattc      300

acccccactg aaaaagatga gtatgcctgc cgtgtgaacc atgtgacttt gtcacagccc      360

aagatagtta agtgggatcg agacatgtaa gcagcatcat ggaggtttga agatgccgca      420

tttggattgg atgaattcca aattctgctt gcttgctttt taatattgat atgcttatac      480

acttacactt tatgcacaaa atgtagggtt ataataatgt taacatggac atgatcttct      540

ttataattct actttgagtg ctgtctccat gtttgatgta tctgagcagg ttgctccaca      600

ggtagctcta ggagggctgg caacttagag gtggggagca gagaattctc ttatccaaca      660

tcaacatctt ggtcagattt gaactcttca atctcttgca ctcaaagctt gttaagatag      720

ttaagcgtgc ataagttaac ttccaattta catactctgc ttagaatttg ggggaaaatt      780

tagaaatata attgacagga ttattggaaa tttgttataa tgaatgaaac attttgtcat      840

ataagattca tatttacttc ttatacattt gataaagtaa ggcatggttg tggttaatct      900

ggtttatttt tgttccacaa gttaaataaa tcataaaact tgatgtgtta tctcttatat      960

ctcactccca ctattacccc tttattttca aacagggaaa cagtcttcaa gttccacttg     1020

gtaaaaaatg tgaacccctt gtatatagag tttggctcac agtgtaaagg gcctcagtga     1080

ttcacatttt ccagattagg aatctgatgc tcaaagaagt taaatggcat agttggggtg     1140

acacagctgt ctagtgggag gccagccttc tatattttag ccagcgttct ttcctgcggg     1200

ccaggtcatg aggagtatgc agactctaag agggagcaaa agtatctgaa ggatttaata     1260

ttttagcaag gaatagatat acaatcatcc cttggtctcc ctgggggatt ggtttcagga     1320

ccccttcttg gacaccaaat ctatggatat ttaagtccct tctataaaat ggtatagtat     1380

ttgcatataa cctatccaca tcctcctgta tactttaaat catttctaga ttacttgtaa     1440

tacctaatac aatgtaaatg ctatgcaaat agttgttatt gtttaaggaa taatgacaag     1500

aaaaaaaagt ctgtacatgc tcagtaaaga cacaaccatc cctttttttc cccagtgttt     1560

ttgatccatg gtttgctgaa tccacagatg tggagcccct ggatacggaa ggcccgctgt     1620

actttgaatg acaaataaca gatttaaaat tttcaaggca tagttttata cctga          1675


<210> 2
<211> 1675
<212> DNA
<213> Homo sapiens

<400> 2
attcctgaag ctgacagcat tcgggccgag atgtctcgct ccgtggcctt agctgtgctc       60

gcgctactct ctctttctgg cctggaggct atccagcgta ctccaaagat tcaggtttac      120

tcacgtcatc cagcagagaa tggaaagtca aatttcctga attgctatgt gtctgggttt      180

catccatccg acattgaagt tgacttactg aagaatggag agagaattga aaaagtggag      240

cattcagact tgtctttcag caaggactgg tctttctatc tcttgtacta cactgaattc      300

acccccactg aaaaagatga gtatgcctgc cgtgtgaacc atgtgacttt gtcacagccc      360

aagatagtta agtgggatcg agacatgtaa gcagcatcat ggaggtttga agatgccgca      420

tttggattgg atgaattcca aattctgctt gcttgctttt taatattgat atgcttatac      480

acttacactt tatgcacaaa atgtagggtt ataataatgt taacatggac atgatcttct      540

ttataattct actttgagtg ctgtctccat gtttgatgta tctgagcagg ttgctccaca      600

ggtagctcta ggagggctgg caacttagag gtggggagca gagaattctc ttatccaaca      660

tcaacatctt ggtcagattt gaactcttca atctcttgca ctcaaagctt gttaagatag      720

ttaagcgtgc ataagttaac ttccaattta catactctgc ttagaatttg ggggaaaatt      780

tagaaatata attgacagga ttattggaaa tttgttataa tgaatgaaac attttgtcat      840

ataagattca tatttacttc ttatacattt gataaagtaa ggcatggttg tggttaatct      900

ggtttatttt tgttccacaa gttaaataaa tcataaaact tgatgtgtta tctcttatat      960

ctcactccca ctattacccc tttattttca aacagggaaa cagtcttcaa gttccacttg     1020

gtaaaaaatg tgaacccctt gtatatagag tttggctcac agtgtaaagg gcctcagtga     1080

ttcacatttt ccagattagg aatctgatgc tcaaagaagt taaatggcat agttggggtg     1140

acacagctgt ctagtgggag gccagccttc tatattttag ccagcgttct ttcctgcggg     1200

ccaggtcatg aggagtatgc agactctaag agggagcaaa agtatctgaa ggatttaata     1260

ttttagcaag gaatagatat acaatcatcc cttggtctcc ctgggggatt ggtttcagga     1320

ccccttcttg gacaccaaat ctatggatat ttaagtccct tctataaaat ggtatagtat     1380

ttgcatataa cctatccaca tcctcctgta tactttaaat catttctaga ttacttgtaa     1440

tacctaatac aatgtaaatg ctatgcaaat agttgttatt gtttaaggaa taatgacaag     1500

aaaaaaaagt ctgtacatgc tcagtaaaga cacaaccatc cctttttttc cccagtgttt     1560

ttgatccatg gtttgctgaa tccacagatg tggagcccct ggatacggaa ggcccgctgt     1620

actttgaatg acaaataaca gatttaaaat tttcaaggca tagttttata cctga          1675


<210> 3
<211> 1508
<212> DNA
<213> Homo sapiens

<400> 3
ttttgaaacc cttcaaaggc agagacttgt ccagcctaac ctgcctgctg ctcctagctc       60

ctgaggctca gggcccttgg cttctgtccg ctctgctcag ggccctccag cgtggccact      120

gctcagccat gctcctgctg ctcgtcccag tgctcgaggt gatttttacc ctgggaggaa      180

ccagagccca gtcggtgacc cagcttggca gccacgtctc tgtctctgaa ggagccctgg      240

ttctgctgag gtgcaactac tcatcgtctg ttccaccata tctcttctgg tatgtgcaat      300

accccaacca aggactccag cttctcctga agtacacatc agcggccacc ctggttaaag      360

gcatcaacgg ttttgaggct gaatttaaga agagtgaaac ctccttccac ctgacgaaac      420

cctcagccca tatgagcgac gcggctgagt acttctgtgc tgtgagtgat ctcgaaccga      480

acagcagtgc ttccaagata atctttggat cagggaccag actcagcatc cggccaaata      540

tccagaaccc tgaccctgcc gtgtaccagc tgagagactc taaatccagt gacaagtctg      600

tctgcctatt caccgatttt gattctcaaa caaatgtgtc acaaagtaag gattctgatg      660

tgtatatcac agacaaaact gtgctagaca tgaggtctat ggacttcaag agcaacagtg      720

ctgtggcctg gagcaacaaa tctgactttg catgtgcaaa cgccttcaac aacagcatta      780

ttccagaaga caccttcttc cccagcccag aaagttcctg tgatgtcaag ctggtcgaga      840

aaagctttga aacagatacg aacctaaact ttcaaaacct gtcagtgatt gggttccgaa      900

tcctcctcct gaaagtggcc gggtttaatc tgctcatgac gctgcggctg tggtccagct      960

gagatctgca agattgtaag acagcctgtg ctccctcgct ccttcctctg cattgcccct     1020

cttctccctc tccaaacaga gggaactctc ctacccccaa ggaggtgaaa gctgctacca     1080

cctctgtgcc cccccggtaa tgccaccaac tggatcctac ccgaatttat gattaagatt     1140

gctgaagagc tgccaaacac tgctgccacc ccctctgttc ccttattgct gcttgtcact     1200

gcctgacatt cacggcagag gcaaggctgc tgcagcctcc cctggctgtg cacattccct     1260

cctgctcccc agagactgcc tccgccatcc cacagatgat ggatcttcag tgggttctct     1320

tgggctctag gtcctggaga atgttgtgag gggtttattt ttttttaata gtgttcataa     1380

agaaatacat agtattcttc ttctcaagac gtggggggaa attatctcat tatcgaggcc     1440

ctgctatgct gtgtgtctgg gcgtgttgta tgtcctgctg ccgatgcctt cattaaaatg     1500

atttggaa                                                              1508


<210> 4
<211> 1221
<212> DNA
<213> Homo sapiens

<400> 4
gggctccagg ctgctctgtt gggtgctgct ttgtctcctg ggagcaggcc cagtaaaggc       60

tggagtcact caaactccaa gatatctgat caaaacgaga ggacagcaag tgacactgag      120

ctgctcccct atctctgggc ataggagtgt atcctggtac caacagaccc caggacaggg      180

ccttcagttc ctctttgaat acttcagtga gacacagaga aacaaaggaa acttccctgg      240

tcgattctca gggcgccagt tctctaactc tcgctctgag atgaatgtga gcaccttgga      300

gctgggggac tcggcccttt atctttgcgc cagcagccgg acagggggcg taaagaattc      360

acccctccac tttgggaacg ggaccaggct cactgtgaca gaggacctga acaaggtgtt      420

cccacccgag gtcgctgtgt ttgagccatc agaagcagag atctcccaca cccaaaaggc      480

cacactggtg tgcctggcca caggcttctt ccctgaccac gtggagctga gctggtgggt      540

gaatgggaag gaggtgcaca gtggggtcag cacggacccg cagcccctca aggagcagcc      600

cgccctcaat gactccagat actgcctgag cagccgcctg agggtctcgg ccaccttctg      660

gcagaacccc cgcaaccact tccgctgtca agtccagttc tacgggctct cggagaatga      720

cgagtggacc caggataggg ccaaacccgt cacccagatc gtcagcgccg aggcctgggg      780

tagagcagac tgtggcttta cctcggtgtc ctaccagcaa ggggtcctgt ctgccaccat      840

cctctatgag atcctgctag ggaaggccac cctgtatgct gtgctggtca gcgcccttgt      900

gttgatggcc atggtcaaga gaaaggattt ctgaaggcag ccctggaagt ggagttagga      960

gcttctaacc cgtcatggtt tcaatacaca ttcttctttt gccagcgctt ctgaagagct     1020

gctctcacct ctctgcatcc caatagatat ccccctatgt gcatgcacac ctgcacactc     1080

acggctgaaa tctccctaac ccagggggac cttagcatgc ctaagtgact aaaccaataa     1140

aaatgttctg gtctggcctg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa a                                               1221


<210> 5
<211> 1434
<212> DNA
<213> Homo sapiens

<400> 5
gatggccgtc atggcgcccc gaaccctcct cctgctactc tcgggggccc tggccctgac       60

ccagacctgg gcgggctccc actccatgag gtatttcttc acatccgtgt cccggcccgg      120

ccgcggggag ccccgcttca tcgccgtggg ctacgtggac gacacgcagt tcgtgcggtt      180

cgacagcgac gccgcgagcc agaagatgga gccgcgggcg ccgtggatag agcaggaggg      240

gccggagtat tgggaccagg agacacggaa tatgaaggcc cactcacaga ctgaccgagc      300

gaacctgggg accctgcgcg gctactacaa ccagagcgag gacggttctc acaccatcca      360

gataatgtat ggctgcgacg tggggccgga cgggcgcttc ctccgcgggt accggcagga      420

cgcctacgac ggcaaggatt acatcgccct gaacgaggac ctgcgctctt ggaccgcggc      480

ggacatggca gctcagatca ccaagcgcaa gtgggaggcg gtccatgcgg cggagcagcg      540

gagagtctac ctggagggcc ggtgcgtgga cgggctccgc agatacctgg agaacgggaa      600

ggagacgctg cagcgcacgg acccccccaa gacacatatg acccaccacc ccatctctga      660

ccatgaggcc accctgaggt gctgggccct gggcttctac cctgcggaga tcacactgac      720

ctggcagcgg gatggggagg accagaccca ggacacggag ctcgtggaga ccaggcctgc      780

aggggatgga accttccaga agtgggcggc tgtggtggtg ccttctggag aggagcagag      840

atacacctgc catgtgcagc atgagggtct gcccaagccc ctcaccctga gatgggagct      900

gtcttcccag cccaccatcc ccatcgtggg catcattgct ggcctggttc tccttggagc      960

tgtgatcact ggagctgtgg tcgctgccgt gatgtggagg aggaagagct cagatagaaa     1020

aggagggagt tacactcagg ctgcaagcag tgacagtgcc cagggctctg atgtgtctct     1080

cacagcttgt aaagtgtgag acagctgcct tgtgtgggac tgagaggcaa gagttgttcc     1140

tgcccttccc tttgtgactt gaagaaccct gactttgttt ctgcaaaggc acctgcatgt     1200

gtctgtgttc gtgtaggcat aatgtgagga ggtggggaga gcaccccacc cccatgtcca     1260

ccatgaccct cttcccacgc tgacctgtgc tccctctcca atcatctttc ctgttccaga     1320

gaggtggggc tgaggtgtct ccatctctgt ctcaacttca tggtgcactg agctgtaact     1380

tcttccttcc ctattaaaat tagaacctga gtataaaaaa aaaaaaaaaa aaaa           1434


<210> 6
<211> 4427
<212> DNA
<213> Homo sapiens

<400> 6
gtcagcgccc cccgcccggc gtctcccggg gccaggtcca ccctctgctg cgccacctgg       60

ggcatcctcc ttccccgttg ccagtctcga tccgccccgt cgttcctggc cctgggcttt      120

gccaccctat gctgacaccc cgtcccagtc ccccttacca ttccccttcg accaccccac      180

ttccgaattg gagccgcttc aactggccct gggcttagcc actctgtgct gaccactctg      240

ccccaggcct ccttaccatt ccccttcgac ctactctctt ccgcattgga gtcgctttaa      300

ctggccctgg ctttggcagc ctgtgctgac ccatgcagtc ctccttacca tccctccctc      360

gacttcccct cttccgatgt tgagcccctc cagccggtcc tggactttgt ctccttccct      420

gccctgccct ctcctgaacc tgagccagct cccatagctc agtctggtct atctgcctgg      480

ccctggccat tgtcactttg cgctgccctc ctctcgcccc cgagtgccct tgctgtgccg      540

ccggaactct gccctctaac gctgccgtct ctctcctgag tccggaccac tttgagctct      600

actggcttct gcgccgcctc tggcccactg tttccccttc ccaggcaggt cctgctttct      660

ctgacctgca ttctctcccc tgggcctgtg ccgctttctg tctgcagctt gtggcctggg      720

tcacctctac ggctggccca gatccttccc tgccgcctcc ttcaggttcc gtcttcctcc      780

actccctctt ccccttgctc tctgctgtgt tgctgcccaa ggatgctctt tccggagcac      840

ttccttctcg gcgctgcacc acgtgatgtc ctctgagcgg atcctccccg tgtctgggtc      900

ctctccgggc atctctcctc cctcacccaa ccccatgccg tcttcactcg ctgggttccc      960

ttttccttct ccttctgggg cctgtgccat ctctcgtttc ttaggatggc cttctccgac     1020

ggatgtctcc cttgcgtccc gcctcccctt cttgtaggcc tgcatcatca ccgtttttct     1080

ggacaacccc aaagtacccc gtctccctgg ctttagccac ctctccatcc tcttgctttc     1140

tttgcctgga caccccgttc tcctgtggat tcgggtcacc tctcactcct ttcatttggg     1200

cagctcccct acccccctta cctctctagt ctgtgctagc tcttccagcc ccctgtcatg     1260

gcatcttcca ggggtccgag agctcagcta gtcttcttcc tccaacccgg gcccctatgt     1320

ccacttcagg acagcatgtt tgctgcctcc agggatcctg tgtccccgag ctgggaccac     1380

cttatattcc cagggccggt taatgtggct ctggttctgg gtacttttat ctgtcccctc     1440

caccccacag tggggccact agggacagga ttggtgacag aaaagcccca tccttaggcc     1500

tcctccttcc tagtctcctg atattgggtc taacccccac ctcctgttag gcagattcct     1560

tatctggtga cacaccccca tttcctggag ccatctctct ccttgccaga acctctaagg     1620

tttgcttacg atggagccag agaggatcct gggagggaga gcttggcagg gggtgggagg     1680

gaaggggggg atgcgtgacc tgcccggttc tcagtggcca ccctgcgcta ccctctccca     1740

gaacctgagc tgctctgacg cggccgtctg gtgcgtttca ctgatcctgg tgctgcagct     1800

tccttacact tcccaagagg agaagcagtt tggaaaaaca aaatcagaat aagttggtcc     1860

tgagttctaa ctttggctct tcacctttct agtccccaat ttatattgtt cctccgtgcg     1920

tcagttttac ctgtgagata aggccagtag ccagccccgt cctggcaggg ctgtggtgag     1980

gaggggggtg tccgtgtgga aaactccctt tgtgagaatg gtgcgtccta ggtgttcacc     2040

aggtcgtggc cgcctctact ccctttctct ttctccatcc ttctttcctt aaagagtccc     2100

cagtgctatc tgggacatat tcctccgccc agagcagggt cccgcttccc taaggccctg     2160

ctctgggctt ctgggtttga gtccttggca agcccaggag aggcgctcag gcttccctgt     2220

cccccttcct cgtccaccat ctcatgcccc tggctctcct gccccttccc tacaggggtt     2280

cctggctctg ctcttcagac tgagccccgt tcccctgcat ccccgttccc ctgcatcccc     2340

cttcccctgc atcccccaga ggccccaggc cacctacttg gcctggaccc cacgagaggc     2400

caccccagcc ctgtctacca ggctgccttt tgggtggatt ctcctccaac tgtggggtga     2460

ctgcttggca aactcactct tcggggtatc ccaggaggcc tggagcattg gggtgggctg     2520

gggttcagag aggagggatt cccttctcag gttacgtggc caagaagcag gggagctggg     2580

tttgggtcag gtctgggtgt ggggtgacca gcttatgctg tttgcccagg acagcctagt     2640

tttagcactg aaaccctcag tcctaggaaa acagggatgg ttggtcactg tctctgggtg     2700

actcttgatt cccggccagt ttctccacct ggggctgtgt ttctcgtcct gcatccttct     2760

ccaggcaggt ccccaagcat cgcccccctg ctgtggctgt tcccaagttc ttagggtacc     2820

ccacgtgggt ttatcaacca cttggtgagg ctggtaccct gcccccattc ctgcacccca     2880

attgccttag tggctagggg gttgggggct agagtaggag gggctggagc caggattctt     2940

agggctgaac agagaagagc tgggggcctg ggctcctggg tttgagagag gaggggctgg     3000

ggcctggact cctgggtccg agggaggagg ggctggggcc tggactcctg ggtctgaggg     3060

tggagggact gggggcctgg actcctgggt ccgagggagg aggggctggg gcctggactc     3120

gtgggtctga gggaggaggg gctgggggcc tggacttctg ggtcttaggg aggcggggct     3180

gggcctggac ccctgggtct gaatggggag aggctggggg cctggactcc ttcatctgag     3240

ggcggaaggg ctggggcctg gcctcctggg ttgaatgggg aggggttggg cctggactct     3300

ggagtccctg gtgcccaggc ctcaggcatc tttcacaggg atgcctgtac tgggcaggtc     3360

cttgaaaggg aaaggcccat tgctctcctt gcccccctcc cctatcgcca tgacaactgg     3420

gtggaaataa acgagccgag ttcatcccgt tcccagggca cgtgcggccc cttcacagcc     3480

cgagtttcca tgacctcatg ctcttggccc tcgtagctcc ctcccgcctc ctccagatgg     3540

gcagctttgg agaggtgagg gacttggggg gtaatttatc ccgtggatct aggagtttag     3600

cttcactcct tcctcagctc cagttcaggt cccggagccc acccagtgtc cacaaggcct     3660

ggggcaagtc cctcctccga ccccctggac ttcggctttt gtccccccaa gttttggacc     3720

cctaagggaa gaatgagaaa cggtggcccg tgtcagcccc tggctgcagg gccccgtgca     3780

gagggggcct cagtgaactg gagtgtgaca gcctggggcc caggcacaca ggtgtgcagc     3840

tgtctcaccc ctctgggagt cccgcccagg cccctgagtc tgtcccagca cagggtggcc     3900

ttcctccacc ctgcatagcc ctgggcccac ggcttcgttc ctgcagagta tctgctgggg     3960

tggtttccga gcttgaccct tggaaggacc tggctgggtt taaggcagga ggggctgggg     4020

gccaggactc ctggctctga aggaggaggg gctggaacct cttccctagt ctgagcactg     4080

gaagcgccac ctgtgggtgg tgacgggggt tttgccgtgt ctaacaggta ccatgtgggg     4140

ttcccgcacc cagatgagaa gccccctccc ttccccgttc acttcctgtt tgcagatagc     4200

caggagtcct ttcgtggttt ccactgagca ctgaaggcct ggccggcctg accactgggc     4260

aaccaggcgt atcttaaaca gccagtggcc agaggctgtt gggtcatttt ccccactgtc     4320

ctagcaccgt gtccctggat ctgttttcgt ggctccctct ggagtcccga cttgctggga     4380

caccgtggct ggggtaggtg cggctgacgg ctgtttccca cccccag                   4427


<210> 7
<211> 1707
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac aggtgtcgtg acgcgggatc cgccaccatg      240

cttctcctgg tgacaagcct tctgctctgt gagttaccac acccagcatt cctcctgatc      300

ccagacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      360

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      420

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      480

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      540

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      600

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc      660

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc      720

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta      780

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt      840

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc      900

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac      960

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc     1020

tcagtcaccg tctcctcagc ggccgcaatt gaagttatgt atcctcctcc ttacctagac     1080

aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg tccaagtccc     1140

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggggg agtcctggct     1200

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc     1260

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag     1320

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag agtgaagttc     1380

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1440

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1500

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1560

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1620

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1680

cacatgcagg ccctgccccc tcgctaa                                         1707


<210> 8
<211> 93
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala 
                85                  90              


<210> 9
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Asp Ala Thr Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu 
1               5                   10                  15      


Ile Ile Lys Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu 
            20                  25                  30          


Gly Pro Asp Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn 
        35                  40                  45              


Gly Arg Trp Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg 
    50                  55                  60                  


Ile Gln Thr Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Ser 
            


<210> 10
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Asp Ala Thr Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu 
1               5                   10                  15      


Ile Ile Lys Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu 
            20                  25                  30          


Gly Pro Asp Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser 
        35                  40                  45              


Gly Arg Trp Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg 
    50                  55                  60                  


Ile Gln Thr Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Ser 
            


<210> 11
<211> 83
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Asp Ala Thr Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu 
1               5                   10                  15      


Ile Ile Lys Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu 
            20                  25                  30          


Gly Pro Asp Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser 
        35                  40                  45              


Gly Arg Trp Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg 
    50                  55                  60                  


Ile Gln Thr Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Ser 
            


<210> 12
<211> 86
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Asp Ala Thr Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu 
1               5                   10                  15      


Ile Ile Lys Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu 
            20                  25                  30          


Gly Pro Asp Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser 
        35                  40                  45              


Gly Arg Trp Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg 
    50                  55                  60                  


Ile Gln Thr Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Thr Gly Gly Ser 
                85      


<210> 13
<211> 87
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Asp Ala Thr Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu 
1               5                   10                  15      


Ile Ile Lys Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu 
            20                  25                  30          


Gly Pro Asp Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser 
        35                  40                  45              


Gly Arg Trp Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg 
    50                  55                  60                  


Ile Gln Thr Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Gly 
65                  70                  75                  80  


Gly Ser Gly Gly Gly Gly Ser 
                85          


<210> 14
<211> 95
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Asp Ala Thr Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu 
1               5                   10                  15      


Ile Ile Lys Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu 
            20                  25                  30          


Gly Pro Asp Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser 
        35                  40                  45              


Gly Arg Trp Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg 
    50                  55                  60                  


Ile Gln Thr Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Lys Glu Ser 
65                  70                  75                  80  


Gly Ser Val Ser Ser Glu Gln Leu Ala Gln Phe Arg Ser Leu Asp 
                85                  90                  95  


<210> 15
<211> 1053
<212> PRT
<213> Staphylococcus aureus

<400> 15
Met Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 16
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Lys Arg Asn Tyr Ile Leu Gly Leu Glu Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 17
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 17
cgcuacucuc ucuuucuggc c                                                 21


<210> 18
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
agcgcgagca cagcuaaggc c                                                 21


<210> 19
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 19
uuuugucugu gauauacaca u                                                 21


<210> 20
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
cuugacagcg gaagugguug c                                                 21


<210> 21
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
ugggucaggg ccagggcccc c                                                 21


<210> 22
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 22
cccugcucug ggcuucuggg u                                                 21


<210> 23
<211> 1707
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 23
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

ccggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac aggtgtcgtg acgcgggatc cgccaccatg      240

cttctcctgg tgacaagcct tctgctctgt gagttaccac acccagcatt cctcctgatc      300

ccagacatcc agatgacaca gactacatcc tccctgtctg cctctctggg agacagagtc      360

accatcagtt gcagggcaag tcaggacatt agtaaatatt taaattggta tcagcagaaa      420

ccagatggaa ctgttaaact cctgatctac catacatcaa gattacactc aggagtccca      480

tcaaggttca gtggcagtgg gtctggaaca gattattctc tcaccattag caacctggag      540

caagaagata ttgccactta cttttgccaa cagggtaata cgcttccgta cacgttcgga      600

ggggggacta agttggaaat aacaggctcc acctctggat ccggcaagcc cggatctggc      660

gagggatcca ccaagggcga ggtgaaactg caggagtcag gacctggcct ggtggcgccc      720

tcacagagcc tgtccgtcac atgcactgtc tcaggggtct cattacccga ctatggtgta      780

agctggattc gccagcctcc acgaaagggt ctggagtggc tgggagtaat atggggtagt      840

gaaaccacat actataattc agctctcaaa tccagactga ccatcatcaa ggacaactcc      900

aagagccaag ttttcttaaa aatgaacagt ctgcaaactg atgacacagc catttactac      960

tgtgccaaac attattacta cggtggtagc tatgctatgg actactgggg tcaaggaacc     1020

tcagtcaccg tctcctcagc ggccgcaatt gaagttatgt atcctcctcc ttacctagac     1080

aatgagaaga gcaatggaac cattatccat gtgaaaggga aacacctttg tccaagtccc     1140

ctatttcccg gaccttctaa gcccttttgg gtgctggtgg tggttggggg agtcctggct     1200

tgctatagct tgctagtaac agtggccttt attattttct gggtgaggag taagaggagc     1260

aggctcctgc acagtgacta catgaacatg actccccgcc gccccgggcc cacccgcaag     1320

cattaccagc cctatgcccc accacgcgac ttcgcagcct atcgctccag agtgaagttc     1380

agcaggagcg cagacgcccc cgcgtaccag cagggccaga accagctcta taacgagctc     1440

aatctaggac gaagagagga gtacgatgtt ttggacaaga gacgtggccg ggaccctgag     1500

atggggggaa agccgagaag gaagaaccct caggaaggcc tgtacaatga actgcagaaa     1560

gataagatgg cggaggccta cagtgagatt gggatgaaag gcgagcgccg gaggggcaag     1620

gggcacgatg gcctttacca gggtctcagt acagccacca aggacaccta cgacgccctt     1680

cacatgcagg ccctgccccc tcgctaa                                         1707


<210> 24
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
tcttaagatc tttgctttcc cttctctata acttcgtata gcatacatta tacgaagtta       60

tattcgtct                                                               69


<210> 25
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Met Lys Arg Asn Tyr Ile Leu Gly Leu Glu Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 26
<211> 1053
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Lys Arg Asn Tyr Ile Leu Gly Leu Ala Ile Gly Ile Thr Ser Val 
1               5                   10                  15      


Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly 
            20                  25                  30          


Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg 
        35                  40                  45              


Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile 
    50                  55                  60                  


Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His 
65                  70                  75                  80  


Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu 
                85                  90                  95      


Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu 
            100                 105                 110         


Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr 
        115                 120                 125             


Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala 
    130                 135                 140                 


Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys 
145                 150                 155                 160 


Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr 
                165                 170                 175     


Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln 
            180                 185                 190         


Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg 
        195                 200                 205             


Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys 
    210                 215                 220                 


Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe 
225                 230                 235                 240 


Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr 
                245                 250                 255     


Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn 
            260                 265                 270         


Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe 
        275                 280                 285             


Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu 
    290                 295                 300                 


Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys 
305                 310                 315                 320 


Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr 
                325                 330                 335     


Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala 
            340                 345                 350         


Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu 
        355                 360                 365             


Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser 
    370                 375                 380                 


Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile 
385                 390                 395                 400 


Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala 
                405                 410                 415     


Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln 
            420                 425                 430         


Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro 
        435                 440                 445             


Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile 
    450                 455                 460                 


Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg 
465                 470                 475                 480 


Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys 
                485                 490                 495     


Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr 
            500                 505                 510         


Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp 
        515                 520                 525             


Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu 
    530                 535                 540                 


Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro 
545                 550                 555                 560 


Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys 
                565                 570                 575     


Gln Glu Glu Ala Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu 
            580                 585                 590         


Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile 
        595                 600                 605             


Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu 
    610                 615                 620                 


Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp 
625                 630                 635                 640 


Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu 
                645                 650                 655     


Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys 
            660                 665                 670         


Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp 
        675                 680                 685             


Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp 
    690                 695                 700                 


Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys 
705                 710                 715                 720 


Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys 
                725                 730                 735     


Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu 
            740                 745                 750         


Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp 
        755                 760                 765             


Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile 
    770                 775                 780                 


Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu 
785                 790                 795                 800 


Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu 
                805                 810                 815     


Lys Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His 
            820                 825                 830         


Asp Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly 
        835                 840                 845             


Asp Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr 
    850                 855                 860                 


Leu Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile 
865                 870                 875                 880 


Lys Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp 
                885                 890                 895     


Tyr Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr 
            900                 905                 910         


Arg Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val 
        915                 920                 925             


Lys Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser 
    930                 935                 940                 


Lys Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala 
945                 950                 955                 960 


Glu Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly 
                965                 970                 975     


Glu Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile 
            980                 985                 990         


Glu Val Asn Met Ile Asp Ile Thr  Tyr Arg Glu Tyr Leu  Glu Asn Met 
        995                 1000                 1005             


Asn Asp  Lys Arg Pro Pro Arg  Ile Ile Lys Thr Ile  Ala Ser Lys 
    1010                 1015                 1020             


Thr Gln  Ser Ile Lys Lys Tyr  Ser Thr Asp Ile Leu  Gly Asn Leu 
    1025                 1030                 1035             


Tyr Glu  Val Lys Ser Lys Lys  His Pro Gln Ile Ile  Lys Lys Gly 
    1040                 1045                 1050             


<210> 27
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Asp Lys Lys Tyr Ser Ile Gly Leu Glu Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Glu  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 28
<211> 1368
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Met Asp Lys Lys Tyr Ser Ile Gly Leu Glu Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp Ala Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Glu  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Gln  Tyr Arg Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210> 29
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 30
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 31
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 32
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 33
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Arg Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Ser 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Arg Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 34
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 34
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Glu Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 35
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Glu Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 36
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 36
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Glu Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 37
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Glu Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 38
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Arg Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Ser 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Arg Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Glu Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 39
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp Ala 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 40
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 40
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp Ala 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 41
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp Ala 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 42
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp Ala 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 43
<211> 1232
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Arg Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Ser 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Arg Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile 
            180                 185                 190         


Thr Ser Val Gly Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile 
        195                 200                 205             


Asp Ala Gly Val Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu 
    210                 215                 220                 


Gly Arg Arg Ser Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg 
225                 230                 235                 240 


His Arg Ile Gln Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu 
                245                 250                 255     


Thr Asp His Ser Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val 
            260                 265                 270         


Lys Gly Leu Ser Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu 
        275                 280                 285             


Leu His Leu Ala Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu 
    290                 295                 300                 


Glu Asp Thr Gly Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn 
305                 310                 315                 320 


Ser Lys Ala Leu Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg 
                325                 330                 335     


Leu Lys Lys Asp Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr 
            340                 345                 350         


Ser Asp Tyr Val Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala 
        355                 360                 365             


Tyr His Gln Leu Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu 
    370                 375                 380                 


Glu Thr Arg Arg Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe 
385                 390                 395                 400 


Gly Trp Lys Asp Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys 
                405                 410                 415     


Thr Tyr Phe Pro Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala 
            420                 425                 430         


Asp Leu Tyr Asn Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg 
        435                 440                 445             


Asp Glu Asn Glu Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu 
    450                 455                 460                 


Asn Val Phe Lys Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys 
465                 470                 475                 480 


Glu Ile Leu Val Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser 
                485                 490                 495     


Thr Gly Lys Pro Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys 
            500                 505                 510         


Asp Ile Thr Ala Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp 
        515                 520                 525             


Gln Ile Ala Lys Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln 
    530                 535                 540                 


Glu Glu Leu Thr Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu 
545                 550                 555                 560 


Gln Ile Ser Asn Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu 
                565                 570                 575     


Lys Ala Ile Asn Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn 
            580                 585                 590         


Gln Ile Ala Ile Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp 
        595                 600                 605             


Leu Ser Gln Gln Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile 
    610                 615                 620                 


Leu Ser Pro Val Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile 
625                 630                 635                 640 


Asn Ala Ile Ile Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu 
                645                 650                 655     


Leu Ala Arg Glu Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu 
            660                 665                 670         


Met Gln Lys Arg Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile 
        675                 680                 685             


Arg Thr Thr Gly Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys 
    690                 695                 700                 


Leu His Asp Met Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile 
705                 710                 715                 720 


Pro Leu Glu Asp Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp Ala 
                725                 730                 735     


Ile Ile Pro Arg Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val 
            740                 745                 750         


Leu Val Lys Gln Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe 
        755                 760                 765             


Gln Tyr Leu Ser Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys 
    770                 775                 780                 


Lys His Ile Leu Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr 
785                 790                 795                 800 


Lys Lys Glu Tyr Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val 
                805                 810                 815     


Gln Lys Asp Phe Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr 
            820                 825                 830         


Arg Gly Leu Met Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu 
        835                 840                 845             


Asp Val Lys Val Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg 
    850                 855                 860                 


Arg Lys Trp Lys Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His 
865                 870                 875                 880 


Ala Glu Asp Ala Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu 
                885                 890                 895     


Trp Lys Lys Leu Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe 
            900                 905                 910         


Glu Glu Lys Gln Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu 
        915                 920                 925             


Tyr Lys Glu Ile Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp 
    930                 935                 940                 


Phe Lys Asp Tyr Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg 
945                 950                 955                 960 


Glu Leu Ile Asn Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly 
                965                 970                 975     


Asn Thr Leu Ile Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn 
            980                 985                 990         


Asp Lys Leu Lys Lys Leu Ile Asn  Lys Ser Pro Glu Lys  Leu Leu Met 
        995                 1000                 1005             


Tyr His  His Asp Pro Gln Thr  Tyr Gln Lys Leu Lys  Leu Ile Met 
    1010                 1015                 1020             


Glu Gln  Tyr Gly Asp Glu Lys  Asn Pro Leu Tyr Lys  Tyr Tyr Glu 
    1025                 1030                 1035             


Glu Thr  Gly Asn Tyr Leu Thr  Lys Tyr Ser Lys Lys  Asp Asn Gly 
    1040                 1045                 1050             


Pro Val  Ile Lys Lys Ile Lys  Tyr Tyr Gly Asn Lys  Leu Asn Ala 
    1055                 1060                 1065             


His Leu  Asp Ile Thr Asp Asp  Tyr Pro Asn Ser Arg  Asn Lys Val 
    1070                 1075                 1080             


Val Lys  Leu Ser Leu Lys Pro  Tyr Arg Phe Asp Val  Tyr Leu Asp 
    1085                 1090                 1095             


Asn Gly  Val Tyr Lys Phe Val  Thr Val Lys Asn Leu  Asp Val Ile 
    1100                 1105                 1110             


Lys Lys  Glu Asn Tyr Tyr Glu  Val Asn Ser Lys Cys  Tyr Glu Glu 
    1115                 1120                 1125             


Ala Lys  Lys Leu Lys Lys Ile  Ser Asn Gln Ala Glu  Phe Ile Ala 
    1130                 1135                 1140             


Ser Phe  Tyr Asn Asn Asp Leu  Ile Lys Ile Asn Gly  Glu Leu Tyr 
    1145                 1150                 1155             


Arg Val  Ile Gly Val Asn Asn  Asp Leu Leu Asn Arg  Ile Glu Val 
    1160                 1165                 1170             


Asn Met  Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
    1175                 1180                 1185             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1190                 1195                 1200             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1205                 1210                 1215             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1220                 1225                 1230         


<210> 44
<211> 1486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val 
            180                 185                 190         


Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys 
        195                 200                 205             


His Ile Gln Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp 
    210                 215                 220                 


His Tyr Lys Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr 
225                 230                 235                 240 


Ala Asp Gln Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser 
                245                 250                 255     


Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn 
            260                 265                 270         


Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr 
        275                 280                 285             


Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His 
    290                 295                 300                 


Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys 
305                 310                 315                 320 


Val Leu Lys Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala 
                325                 330                 335     


Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr 
            340                 345                 350         


Glu Asn Arg Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile 
        355                 360                 365             


Pro His Arg Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys 
    370                 375                 380                 


His Ile Phe Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His 
385                 390                 395                 400 


Phe Glu Asn Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile 
                405                 410                 415     


Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr 
            420                 425                 430         


Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala 
        435                 440                 445             


Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile 
    450                 455                 460                 


Gln Lys Asn Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg 
465                 470                 475                 480 


Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser 
                485                 490                 495     


Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe 
            500                 505                 510         


Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala 
        515                 520                 525             


Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe 
    530                 535                 540                 


Ile Ser His Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His 
545                 550                 555                 560 


Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu 
                565                 570                 575     


Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu 
            580                 585                 590         


Lys His Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys 
        595                 600                 605             


Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His 
    610                 615                 620                 


Ala His Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln 
625                 630                 635                 640 


Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu 
                645                 650                 655     


Tyr His Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp 
            660                 665                 670         


Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro 
        675                 680                 685             


Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro 
    690                 695                 700                 


Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala 
705                 710                 715                 720 


Ser Gly Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe 
                725                 730                 735     


Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly 
            740                 745                 750         


Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly 
        755                 760                 765             


Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile 
    770                 775                 780                 


Pro Lys Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr 
785                 790                 795                 800 


His Thr Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu 
                805                 810                 815     


Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys 
            820                 825                 830         


Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr 
        835                 840                 845             


Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser 
    850                 855                 860                 


Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser 
865                 870                 875                 880 


Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu 
                885                 890                 895     


Leu Tyr His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp 
            900                 905                 910         


Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
        915                 920                 925             


Phe Ala Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp 
    930                 935                 940                 


Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu 
945                 950                 955                 960 


Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg 
                965                 970                 975     


Met Ala His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp 
            980                 985                 990         


Gln Lys Thr Pro Ile Pro Asp Thr  Leu Tyr Gln Glu Leu  Tyr Asp Tyr 
        995                 1000                 1005             


Val Asn  His Arg Leu Ser His  Asp Leu Ser Asp Glu  Ala Arg Ala 
    1010                 1015                 1020             


Leu Leu  Pro Asn Val Ile Thr  Lys Glu Val Ser His  Glu Ile Ile 
    1025                 1030                 1035             


Lys Asp  Arg Arg Phe Thr Ser  Asp Lys Phe Phe Phe  His Val Pro 
    1040                 1045                 1050             


Ile Thr  Leu Asn Tyr Gln Ala  Ala Asn Ser Pro Ser  Lys Phe Asn 
    1055                 1060                 1065             


Gln Arg  Val Asn Ala Tyr Leu  Lys Glu His Pro Glu  Thr Pro Ile 
    1070                 1075                 1080             


Ile Gly  Ile Asp Arg Gly Glu  Arg Asn Leu Ile Tyr  Ile Thr Val 
    1085                 1090                 1095             


Ile Asp  Ser Thr Gly Lys Ile  Leu Glu Gln Arg Ser  Leu Asn Thr 
    1100                 1105                 1110             


Ile Gln  Gln Phe Asp Tyr Gln  Lys Lys Leu Asp Asn  Arg Glu Lys 
    1115                 1120                 1125             


Glu Arg  Val Ala Ala Arg Gln  Ala Trp Ser Val Val  Gly Thr Ile 
    1130                 1135                 1140             


Lys Asp  Leu Lys Gln Gly Tyr  Leu Ser Gln Val Ile  His Glu Ile 
    1145                 1150                 1155             


Val Asp  Leu Met Ile His Tyr  Gln Ala Val Val Val  Leu Glu Asn 
    1160                 1165                 1170             


Leu Asn  Phe Gly Phe Lys Ser  Lys Arg Thr Gly Ile  Ala Glu Lys 
    1175                 1180                 1185             


Ala Val  Tyr Gln Gln Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1190                 1195                 1200             


Cys Leu  Val Leu Lys Asp Tyr  Pro Ala Glu Lys Val  Gly Gly Val 
    1205                 1210                 1215             


Leu Asn  Pro Tyr Gln Leu Thr  Asp Gln Phe Thr Ser  Phe Ala Lys 
    1220                 1225                 1230             


Met Gly  Thr Gln Ser Gly Phe  Leu Phe Tyr Val Pro  Ala Pro Tyr 
    1235                 1240                 1245             


Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe Val Asp  Pro Phe Val 
    1250                 1255                 1260             


Trp Lys  Thr Ile Lys Asn His  Glu Ser Arg Lys His  Phe Leu Glu 
    1265                 1270                 1275             


Gly Phe  Asp Phe Leu His Tyr  Asp Val Lys Thr Gly  Asp Phe Ile 
    1280                 1285                 1290             


Leu His  Phe Lys Met Asn Arg  Asn Leu Ser Phe Gln  Arg Gly Leu 
    1295                 1300                 1305             


Pro Gly  Phe Met Pro Ala Trp  Asp Ile Val Phe Glu  Lys Asn Glu 
    1310                 1315                 1320             


Thr Gln  Phe Asp Ala Lys Gly  Thr Pro Phe Ile Ala  Gly Lys Arg 
    1325                 1330                 1335             


Ile Val  Pro Val Ile Glu Asn  His Arg Phe Thr Gly  Arg Tyr Arg 
    1340                 1345                 1350             


Asp Leu  Tyr Pro Ala Asn Glu  Leu Ile Ala Leu Leu  Glu Glu Lys 
    1355                 1360                 1365             


Gly Ile  Val Phe Arg Asp Gly  Ser Asn Ile Leu Pro  Lys Leu Leu 
    1370                 1375                 1380             


Glu Asn  Asp Asp Ser His Ala  Ile Asp Thr Met Val  Ala Leu Ile 
    1385                 1390                 1395             


Arg Ser  Val Leu Gln Met Arg  Asn Ser Asn Ala Ala  Thr Gly Glu 
    1400                 1405                 1410             


Asp Tyr  Ile Asn Ser Pro Val  Arg Asp Leu Asn Gly  Val Cys Phe 
    1415                 1420                 1425             


Asp Ser  Arg Phe Gln Asn Pro  Glu Trp Pro Met Asp  Ala Asp Ala 
    1430                 1435                 1440             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Gln Leu  Leu Leu Asn 
    1445                 1450                 1455             


His Leu  Lys Glu Ser Lys Asp  Leu Lys Leu Gln Asn  Gly Ile Ser 
    1460                 1465                 1470             


Asn Gln  Asp Trp Leu Ala Tyr  Ile Gln Glu Leu Arg  Asn 
    1475                 1480                 1485     


<210> 45
<211> 1486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 45
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val 
            180                 185                 190         


Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys 
        195                 200                 205             


His Ile Gln Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp 
    210                 215                 220                 


His Tyr Lys Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr 
225                 230                 235                 240 


Ala Asp Gln Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser 
                245                 250                 255     


Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn 
            260                 265                 270         


Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr 
        275                 280                 285             


Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His 
    290                 295                 300                 


Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys 
305                 310                 315                 320 


Val Leu Lys Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala 
                325                 330                 335     


Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr 
            340                 345                 350         


Glu Asn Arg Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile 
        355                 360                 365             


Pro His Arg Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys 
    370                 375                 380                 


His Ile Phe Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His 
385                 390                 395                 400 


Phe Glu Asn Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile 
                405                 410                 415     


Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr 
            420                 425                 430         


Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala 
        435                 440                 445             


Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile 
    450                 455                 460                 


Gln Lys Asn Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg 
465                 470                 475                 480 


Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser 
                485                 490                 495     


Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe 
            500                 505                 510         


Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala 
        515                 520                 525             


Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe 
    530                 535                 540                 


Ile Ser His Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His 
545                 550                 555                 560 


Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu 
                565                 570                 575     


Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu 
            580                 585                 590         


Lys His Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys 
        595                 600                 605             


Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His 
    610                 615                 620                 


Ala His Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln 
625                 630                 635                 640 


Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu 
                645                 650                 655     


Tyr His Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp 
            660                 665                 670         


Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro 
        675                 680                 685             


Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro 
    690                 695                 700                 


Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala 
705                 710                 715                 720 


Ser Gly Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe 
                725                 730                 735     


Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly 
            740                 745                 750         


Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly 
        755                 760                 765             


Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile 
    770                 775                 780                 


Pro Lys Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr 
785                 790                 795                 800 


His Thr Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu 
                805                 810                 815     


Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys 
            820                 825                 830         


Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr 
        835                 840                 845             


Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser 
    850                 855                 860                 


Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser 
865                 870                 875                 880 


Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu 
                885                 890                 895     


Leu Tyr His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp 
            900                 905                 910         


Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
        915                 920                 925             


Phe Ala Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp 
    930                 935                 940                 


Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu 
945                 950                 955                 960 


Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg 
                965                 970                 975     


Met Ala His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp 
            980                 985                 990         


Gln Lys Thr Pro Ile Pro Asp Thr  Leu Tyr Gln Glu Leu  Tyr Asp Tyr 
        995                 1000                 1005             


Val Asn  His Arg Leu Ser His  Asp Leu Ser Asp Glu  Ala Arg Ala 
    1010                 1015                 1020             


Leu Leu  Pro Asn Val Ile Thr  Lys Glu Val Ser His  Glu Ile Ile 
    1025                 1030                 1035             


Lys Asp  Arg Arg Phe Thr Ser  Asp Lys Phe Phe Phe  His Val Pro 
    1040                 1045                 1050             


Ile Thr  Leu Asn Tyr Gln Ala  Ala Asn Ser Pro Ser  Lys Phe Asn 
    1055                 1060                 1065             


Gln Arg  Val Asn Ala Tyr Leu  Lys Glu His Pro Glu  Thr Pro Ile 
    1070                 1075                 1080             


Ile Gly  Ile Asp Arg Gly Glu  Arg Asn Leu Ile Tyr  Ile Thr Val 
    1085                 1090                 1095             


Ile Asp  Ser Thr Gly Lys Ile  Leu Glu Gln Arg Ser  Leu Asn Thr 
    1100                 1105                 1110             


Ile Gln  Gln Phe Asp Tyr Gln  Lys Lys Leu Asp Asn  Arg Glu Lys 
    1115                 1120                 1125             


Glu Arg  Val Ala Ala Arg Gln  Ala Trp Ser Val Val  Gly Thr Ile 
    1130                 1135                 1140             


Lys Asp  Leu Lys Gln Gly Tyr  Leu Ser Gln Val Ile  His Glu Ile 
    1145                 1150                 1155             


Val Asp  Leu Met Ile His Tyr  Gln Ala Val Val Val  Leu Glu Asn 
    1160                 1165                 1170             


Leu Asn  Phe Gly Phe Lys Ser  Lys Arg Thr Gly Ile  Ala Glu Lys 
    1175                 1180                 1185             


Ala Val  Tyr Gln Gln Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1190                 1195                 1200             


Cys Leu  Val Leu Lys Asp Tyr  Pro Ala Glu Lys Val  Gly Gly Val 
    1205                 1210                 1215             


Leu Asn  Pro Tyr Gln Leu Thr  Asp Gln Phe Thr Ser  Phe Ala Lys 
    1220                 1225                 1230             


Met Gly  Thr Gln Ser Gly Phe  Leu Phe Tyr Val Pro  Ala Pro Tyr 
    1235                 1240                 1245             


Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe Val Asp  Pro Phe Val 
    1250                 1255                 1260             


Trp Lys  Thr Ile Lys Asn His  Glu Ser Arg Lys His  Phe Leu Glu 
    1265                 1270                 1275             


Gly Phe  Asp Phe Leu His Tyr  Asp Val Lys Thr Gly  Asp Phe Ile 
    1280                 1285                 1290             


Leu His  Phe Lys Met Asn Arg  Asn Leu Ser Phe Gln  Arg Gly Leu 
    1295                 1300                 1305             


Pro Gly  Phe Met Pro Ala Trp  Asp Ile Val Phe Glu  Lys Asn Glu 
    1310                 1315                 1320             


Thr Gln  Phe Asp Ala Lys Gly  Thr Pro Phe Ile Ala  Gly Lys Arg 
    1325                 1330                 1335             


Ile Val  Pro Val Ile Glu Asn  His Arg Phe Thr Gly  Arg Tyr Arg 
    1340                 1345                 1350             


Asp Leu  Tyr Pro Ala Asn Glu  Leu Ile Ala Leu Leu  Glu Glu Lys 
    1355                 1360                 1365             


Gly Ile  Val Phe Arg Asp Gly  Ser Asn Ile Leu Pro  Lys Leu Leu 
    1370                 1375                 1380             


Glu Asn  Asp Asp Ser His Ala  Ile Asp Thr Met Val  Ala Leu Ile 
    1385                 1390                 1395             


Arg Ser  Val Leu Gln Met Arg  Asn Ser Asn Ala Ala  Thr Gly Glu 
    1400                 1405                 1410             


Asp Tyr  Ile Asn Ser Pro Val  Arg Asp Leu Asn Gly  Val Cys Phe 
    1415                 1420                 1425             


Asp Ser  Arg Phe Gln Asn Pro  Glu Trp Pro Met Asp  Ala Asp Ala 
    1430                 1435                 1440             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Gln Leu  Leu Leu Asn 
    1445                 1450                 1455             


His Leu  Lys Glu Ser Lys Asp  Leu Lys Leu Gln Asn  Gly Ile Ser 
    1460                 1465                 1470             


Asn Gln  Asp Trp Leu Ala Tyr  Ile Gln Glu Leu Arg  Asn 
    1475                 1480                 1485     


<210> 46
<211> 1486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 46
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val 
            180                 185                 190         


Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys 
        195                 200                 205             


His Ile Gln Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp 
    210                 215                 220                 


His Tyr Lys Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr 
225                 230                 235                 240 


Ala Asp Gln Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser 
                245                 250                 255     


Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn 
            260                 265                 270         


Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr 
        275                 280                 285             


Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His 
    290                 295                 300                 


Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys 
305                 310                 315                 320 


Val Leu Lys Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala 
                325                 330                 335     


Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr 
            340                 345                 350         


Glu Asn Arg Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile 
        355                 360                 365             


Pro His Arg Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys 
    370                 375                 380                 


His Ile Phe Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His 
385                 390                 395                 400 


Phe Glu Asn Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile 
                405                 410                 415     


Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr 
            420                 425                 430         


Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala 
        435                 440                 445             


Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile 
    450                 455                 460                 


Gln Lys Asn Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg 
465                 470                 475                 480 


Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser 
                485                 490                 495     


Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe 
            500                 505                 510         


Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala 
        515                 520                 525             


Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe 
    530                 535                 540                 


Ile Ser His Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His 
545                 550                 555                 560 


Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu 
                565                 570                 575     


Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu 
            580                 585                 590         


Lys His Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys 
        595                 600                 605             


Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His 
    610                 615                 620                 


Ala His Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln 
625                 630                 635                 640 


Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu 
                645                 650                 655     


Tyr His Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp 
            660                 665                 670         


Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro 
        675                 680                 685             


Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro 
    690                 695                 700                 


Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala 
705                 710                 715                 720 


Ser Gly Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe 
                725                 730                 735     


Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly 
            740                 745                 750         


Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly 
        755                 760                 765             


Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile 
    770                 775                 780                 


Pro Lys Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr 
785                 790                 795                 800 


His Thr Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu 
                805                 810                 815     


Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys 
            820                 825                 830         


Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr 
        835                 840                 845             


Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser 
    850                 855                 860                 


Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser 
865                 870                 875                 880 


Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu 
                885                 890                 895     


Leu Tyr His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp 
            900                 905                 910         


Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
        915                 920                 925             


Phe Ala Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp 
    930                 935                 940                 


Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu 
945                 950                 955                 960 


Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg 
                965                 970                 975     


Met Ala His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp 
            980                 985                 990         


Gln Lys Thr Pro Ile Pro Asp Thr  Leu Tyr Gln Glu Leu  Tyr Asp Tyr 
        995                 1000                 1005             


Val Asn  His Arg Leu Ser His  Asp Leu Ser Asp Glu  Ala Arg Ala 
    1010                 1015                 1020             


Leu Leu  Pro Asn Val Ile Thr  Lys Glu Val Ser His  Glu Ile Ile 
    1025                 1030                 1035             


Lys Asp  Arg Arg Phe Thr Ser  Asp Lys Phe Phe Phe  His Val Pro 
    1040                 1045                 1050             


Ile Thr  Leu Asn Tyr Gln Ala  Ala Asn Ser Pro Ser  Lys Phe Asn 
    1055                 1060                 1065             


Gln Arg  Val Asn Ala Tyr Leu  Lys Glu His Pro Glu  Thr Pro Ile 
    1070                 1075                 1080             


Ile Gly  Ile Asp Arg Gly Glu  Arg Asn Leu Ile Tyr  Ile Thr Val 
    1085                 1090                 1095             


Ile Asp  Ser Thr Gly Lys Ile  Leu Glu Gln Arg Ser  Leu Asn Thr 
    1100                 1105                 1110             


Ile Gln  Gln Phe Asp Tyr Gln  Lys Lys Leu Asp Asn  Arg Glu Lys 
    1115                 1120                 1125             


Glu Arg  Val Ala Ala Arg Gln  Ala Trp Ser Val Val  Gly Thr Ile 
    1130                 1135                 1140             


Lys Asp  Leu Lys Gln Gly Tyr  Leu Ser Gln Val Ile  His Glu Ile 
    1145                 1150                 1155             


Val Asp  Leu Met Ile His Tyr  Gln Ala Val Val Val  Leu Glu Asn 
    1160                 1165                 1170             


Leu Asn  Phe Gly Phe Lys Ser  Lys Arg Thr Gly Ile  Ala Glu Lys 
    1175                 1180                 1185             


Ala Val  Tyr Gln Gln Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1190                 1195                 1200             


Cys Leu  Val Leu Lys Asp Tyr  Pro Ala Glu Lys Val  Gly Gly Val 
    1205                 1210                 1215             


Leu Asn  Pro Tyr Gln Leu Thr  Asp Gln Phe Thr Ser  Phe Ala Lys 
    1220                 1225                 1230             


Met Gly  Thr Gln Ser Gly Phe  Leu Phe Tyr Val Pro  Ala Pro Tyr 
    1235                 1240                 1245             


Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe Val Asp  Pro Phe Val 
    1250                 1255                 1260             


Trp Lys  Thr Ile Lys Asn His  Glu Ser Arg Lys His  Phe Leu Glu 
    1265                 1270                 1275             


Gly Phe  Asp Phe Leu His Tyr  Asp Val Lys Thr Gly  Asp Phe Ile 
    1280                 1285                 1290             


Leu His  Phe Lys Met Asn Arg  Asn Leu Ser Phe Gln  Arg Gly Leu 
    1295                 1300                 1305             


Pro Gly  Phe Met Pro Ala Trp  Asp Ile Val Phe Glu  Lys Asn Glu 
    1310                 1315                 1320             


Thr Gln  Phe Asp Ala Lys Gly  Thr Pro Phe Ile Ala  Gly Lys Arg 
    1325                 1330                 1335             


Ile Val  Pro Val Ile Glu Asn  His Arg Phe Thr Gly  Arg Tyr Arg 
    1340                 1345                 1350             


Asp Leu  Tyr Pro Ala Asn Glu  Leu Ile Ala Leu Leu  Glu Glu Lys 
    1355                 1360                 1365             


Gly Ile  Val Phe Arg Asp Gly  Ser Asn Ile Leu Pro  Lys Leu Leu 
    1370                 1375                 1380             


Glu Asn  Asp Asp Ser His Ala  Ile Asp Thr Met Val  Ala Leu Ile 
    1385                 1390                 1395             


Arg Ser  Val Leu Gln Met Arg  Asn Ser Asn Ala Ala  Thr Gly Glu 
    1400                 1405                 1410             


Asp Tyr  Ile Asn Ser Pro Val  Arg Asp Leu Asn Gly  Val Cys Phe 
    1415                 1420                 1425             


Asp Ser  Arg Phe Gln Asn Pro  Glu Trp Pro Met Asp  Ala Asp Ala 
    1430                 1435                 1440             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Gln Leu  Leu Leu Asn 
    1445                 1450                 1455             


His Leu  Lys Glu Ser Lys Asp  Leu Lys Leu Gln Asn  Gly Ile Ser 
    1460                 1465                 1470             


Asn Gln  Asp Trp Leu Ala Tyr  Ile Gln Glu Leu Arg  Asn 
    1475                 1480                 1485     


<210> 47
<211> 1486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 47
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Phe Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Arg Pro Gly Ser Lys Ser Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val 
            180                 185                 190         


Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys 
        195                 200                 205             


His Ile Gln Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp 
    210                 215                 220                 


His Tyr Lys Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr 
225                 230                 235                 240 


Ala Asp Gln Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser 
                245                 250                 255     


Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn 
            260                 265                 270         


Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr 
        275                 280                 285             


Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His 
    290                 295                 300                 


Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys 
305                 310                 315                 320 


Val Leu Lys Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala 
                325                 330                 335     


Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr 
            340                 345                 350         


Glu Asn Arg Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile 
        355                 360                 365             


Pro His Arg Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys 
    370                 375                 380                 


His Ile Phe Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His 
385                 390                 395                 400 


Phe Glu Asn Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile 
                405                 410                 415     


Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr 
            420                 425                 430         


Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala 
        435                 440                 445             


Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile 
    450                 455                 460                 


Gln Lys Asn Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg 
465                 470                 475                 480 


Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser 
                485                 490                 495     


Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe 
            500                 505                 510         


Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala 
        515                 520                 525             


Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe 
    530                 535                 540                 


Ile Ser His Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His 
545                 550                 555                 560 


Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu 
                565                 570                 575     


Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu 
            580                 585                 590         


Lys His Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys 
        595                 600                 605             


Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His 
    610                 615                 620                 


Ala His Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln 
625                 630                 635                 640 


Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu 
                645                 650                 655     


Tyr His Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp 
            660                 665                 670         


Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro 
        675                 680                 685             


Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro 
    690                 695                 700                 


Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala 
705                 710                 715                 720 


Ser Gly Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe 
                725                 730                 735     


Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly 
            740                 745                 750         


Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly 
        755                 760                 765             


Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile 
    770                 775                 780                 


Pro Lys Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr 
785                 790                 795                 800 


His Thr Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu 
                805                 810                 815     


Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys 
            820                 825                 830         


Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr 
        835                 840                 845             


Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser 
    850                 855                 860                 


Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser 
865                 870                 875                 880 


Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu 
                885                 890                 895     


Leu Tyr His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp 
            900                 905                 910         


Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
        915                 920                 925             


Phe Ala Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp 
    930                 935                 940                 


Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu 
945                 950                 955                 960 


Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg 
                965                 970                 975     


Met Ala His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp 
            980                 985                 990         


Gln Lys Thr Pro Ile Pro Asp Thr  Leu Tyr Gln Glu Leu  Tyr Asp Tyr 
        995                 1000                 1005             


Val Asn  His Arg Leu Ser His  Asp Leu Ser Asp Glu  Ala Arg Ala 
    1010                 1015                 1020             


Leu Leu  Pro Asn Val Ile Thr  Lys Glu Val Ser His  Glu Ile Ile 
    1025                 1030                 1035             


Lys Asp  Arg Arg Phe Thr Ser  Asp Lys Phe Phe Phe  His Val Pro 
    1040                 1045                 1050             


Ile Thr  Leu Asn Tyr Gln Ala  Ala Asn Ser Pro Ser  Lys Phe Asn 
    1055                 1060                 1065             


Gln Arg  Val Asn Ala Tyr Leu  Lys Glu His Pro Glu  Thr Pro Ile 
    1070                 1075                 1080             


Ile Gly  Ile Asp Arg Gly Glu  Arg Asn Leu Ile Tyr  Ile Thr Val 
    1085                 1090                 1095             


Ile Asp  Ser Thr Gly Lys Ile  Leu Glu Gln Arg Ser  Leu Asn Thr 
    1100                 1105                 1110             


Ile Gln  Gln Phe Asp Tyr Gln  Lys Lys Leu Asp Asn  Arg Glu Lys 
    1115                 1120                 1125             


Glu Arg  Val Ala Ala Arg Gln  Ala Trp Ser Val Val  Gly Thr Ile 
    1130                 1135                 1140             


Lys Asp  Leu Lys Gln Gly Tyr  Leu Ser Gln Val Ile  His Glu Ile 
    1145                 1150                 1155             


Val Asp  Leu Met Ile His Tyr  Gln Ala Val Val Val  Leu Glu Asn 
    1160                 1165                 1170             


Leu Asn  Phe Gly Phe Lys Ser  Lys Arg Thr Gly Ile  Ala Glu Lys 
    1175                 1180                 1185             


Ala Val  Tyr Gln Gln Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1190                 1195                 1200             


Cys Leu  Val Leu Lys Asp Tyr  Pro Ala Glu Lys Val  Gly Gly Val 
    1205                 1210                 1215             


Leu Asn  Pro Tyr Gln Leu Thr  Asp Gln Phe Thr Ser  Phe Ala Lys 
    1220                 1225                 1230             


Met Gly  Thr Gln Ser Gly Phe  Leu Phe Tyr Val Pro  Ala Pro Tyr 
    1235                 1240                 1245             


Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe Val Asp  Pro Phe Val 
    1250                 1255                 1260             


Trp Lys  Thr Ile Lys Asn His  Glu Ser Arg Lys His  Phe Leu Glu 
    1265                 1270                 1275             


Gly Phe  Asp Phe Leu His Tyr  Asp Val Lys Thr Gly  Asp Phe Ile 
    1280                 1285                 1290             


Leu His  Phe Lys Met Asn Arg  Asn Leu Ser Phe Gln  Arg Gly Leu 
    1295                 1300                 1305             


Pro Gly  Phe Met Pro Ala Trp  Asp Ile Val Phe Glu  Lys Asn Glu 
    1310                 1315                 1320             


Thr Gln  Phe Asp Ala Lys Gly  Thr Pro Phe Ile Ala  Gly Lys Arg 
    1325                 1330                 1335             


Ile Val  Pro Val Ile Glu Asn  His Arg Phe Thr Gly  Arg Tyr Arg 
    1340                 1345                 1350             


Asp Leu  Tyr Pro Ala Asn Glu  Leu Ile Ala Leu Leu  Glu Glu Lys 
    1355                 1360                 1365             


Gly Ile  Val Phe Arg Asp Gly  Ser Asn Ile Leu Pro  Lys Leu Leu 
    1370                 1375                 1380             


Glu Asn  Asp Asp Ser His Ala  Ile Asp Thr Met Val  Ala Leu Ile 
    1385                 1390                 1395             


Arg Ser  Val Leu Gln Met Arg  Asn Ser Asn Ala Ala  Thr Gly Glu 
    1400                 1405                 1410             


Asp Tyr  Ile Asn Ser Pro Val  Arg Asp Leu Asn Gly  Val Cys Phe 
    1415                 1420                 1425             


Asp Ser  Arg Phe Gln Asn Pro  Glu Trp Pro Met Asp  Ala Asp Ala 
    1430                 1435                 1440             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Gln Leu  Leu Leu Asn 
    1445                 1450                 1455             


His Leu  Lys Glu Ser Lys Asp  Leu Lys Leu Gln Asn  Gly Ile Ser 
    1460                 1465                 1470             


Asn Gln  Asp Trp Leu Ala Tyr  Ile Gln Glu Leu Arg  Asn 
    1475                 1480                 1485     


<210> 48
<211> 1486
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 48
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Arg Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Ser 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Arg Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gly Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val 
            180                 185                 190         


Ser Lys Thr Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys 
        195                 200                 205             


His Ile Gln Glu Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp 
    210                 215                 220                 


His Tyr Lys Glu Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr 
225                 230                 235                 240 


Ala Asp Gln Cys Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser 
                245                 250                 255     


Ala Ala Ile Asp Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn 
            260                 265                 270         


Ala Leu Ile Glu Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr 
        275                 280                 285             


Phe Ile Gly Arg Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His 
    290                 295                 300                 


Ala Glu Ile Tyr Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys 
305                 310                 315                 320 


Val Leu Lys Gln Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala 
                325                 330                 335     


Leu Leu Arg Ser Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr 
            340                 345                 350         


Glu Asn Arg Lys Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile 
        355                 360                 365             


Pro His Arg Ile Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys 
    370                 375                 380                 


His Ile Phe Thr Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His 
385                 390                 395                 400 


Phe Glu Asn Val Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile 
                405                 410                 415     


Glu Glu Val Phe Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr 
            420                 425                 430         


Gln Ile Asp Leu Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala 
        435                 440                 445             


Gly Thr Glu Lys Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile 
    450                 455                 460                 


Gln Lys Asn Asp Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg 
465                 470                 475                 480 


Phe Ile Pro Leu Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser 
                485                 490                 495     


Phe Ile Leu Glu Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe 
            500                 505                 510         


Cys Lys Tyr Lys Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala 
        515                 520                 525             


Glu Ala Leu Phe Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe 
    530                 535                 540                 


Ile Ser His Lys Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His 
545                 550                 555                 560 


Trp Asp Thr Leu Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu 
                565                 570                 575     


Thr Gly Lys Ile Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu 
            580                 585                 590         


Lys His Glu Asp Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys 
        595                 600                 605             


Glu Leu Ser Glu Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His 
    610                 615                 620                 


Ala His Ala Ala Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln 
625                 630                 635                 640 


Glu Glu Lys Glu Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu 
                645                 650                 655     


Tyr His Leu Leu Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp 
            660                 665                 670         


Pro Glu Phe Ser Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro 
        675                 680                 685             


Ser Leu Ser Phe Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro 
    690                 695                 700                 


Tyr Ser Val Glu Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala 
705                 710                 715                 720 


Ser Gly Trp Asp Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe 
                725                 730                 735     


Val Lys Asn Gly Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly 
            740                 745                 750         


Arg Tyr Lys Ala Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly 
        755                 760                 765             


Phe Asp Lys Met Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile 
    770                 775                 780                 


Pro Lys Cys Ser Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr 
785                 790                 795                 800 


His Thr Thr Pro Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu 
                805                 810                 815     


Ile Thr Lys Glu Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys 
            820                 825                 830         


Lys Phe Gln Thr Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr 
        835                 840                 845             


Arg Glu Ala Leu Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser 
    850                 855                 860                 


Lys Tyr Thr Lys Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser 
865                 870                 875                 880 


Ser Gln Tyr Lys Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu 
                885                 890                 895     


Leu Tyr His Ile Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp 
            900                 905                 910         


Ala Val Glu Thr Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp 
        915                 920                 925             


Phe Ala Lys Gly His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp 
    930                 935                 940                 


Thr Gly Leu Phe Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu 
945                 950                 955                 960 


Asn Gly Gln Ala Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg 
                965                 970                 975     


Met Ala His Arg Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp 
            980                 985                 990         


Gln Lys Thr Pro Ile Pro Asp Thr  Leu Tyr Gln Glu Leu  Tyr Asp Tyr 
        995                 1000                 1005             


Val Asn  His Arg Leu Ser His  Asp Leu Ser Asp Glu  Ala Arg Ala 
    1010                 1015                 1020             


Leu Leu  Pro Asn Val Ile Thr  Lys Glu Val Ser His  Glu Ile Ile 
    1025                 1030                 1035             


Lys Asp  Arg Arg Phe Thr Ser  Asp Lys Phe Phe Phe  His Val Pro 
    1040                 1045                 1050             


Ile Thr  Leu Asn Tyr Gln Ala  Ala Asn Ser Pro Ser  Lys Phe Asn 
    1055                 1060                 1065             


Gln Arg  Val Asn Ala Tyr Leu  Lys Glu His Pro Glu  Thr Pro Ile 
    1070                 1075                 1080             


Ile Gly  Ile Asp Arg Gly Glu  Arg Asn Leu Ile Tyr  Ile Thr Val 
    1085                 1090                 1095             


Ile Asp  Ser Thr Gly Lys Ile  Leu Glu Gln Arg Ser  Leu Asn Thr 
    1100                 1105                 1110             


Ile Gln  Gln Phe Asp Tyr Gln  Lys Lys Leu Asp Asn  Arg Glu Lys 
    1115                 1120                 1125             


Glu Arg  Val Ala Ala Arg Gln  Ala Trp Ser Val Val  Gly Thr Ile 
    1130                 1135                 1140             


Lys Asp  Leu Lys Gln Gly Tyr  Leu Ser Gln Val Ile  His Glu Ile 
    1145                 1150                 1155             


Val Asp  Leu Met Ile His Tyr  Gln Ala Val Val Val  Leu Glu Asn 
    1160                 1165                 1170             


Leu Asn  Phe Gly Phe Lys Ser  Lys Arg Thr Gly Ile  Ala Glu Lys 
    1175                 1180                 1185             


Ala Val  Tyr Gln Gln Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1190                 1195                 1200             


Cys Leu  Val Leu Lys Asp Tyr  Pro Ala Glu Lys Val  Gly Gly Val 
    1205                 1210                 1215             


Leu Asn  Pro Tyr Gln Leu Thr  Asp Gln Phe Thr Ser  Phe Ala Lys 
    1220                 1225                 1230             


Met Gly  Thr Gln Ser Gly Phe  Leu Phe Tyr Val Pro  Ala Pro Tyr 
    1235                 1240                 1245             


Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe Val Asp  Pro Phe Val 
    1250                 1255                 1260             


Trp Lys  Thr Ile Lys Asn His  Glu Ser Arg Lys His  Phe Leu Glu 
    1265                 1270                 1275             


Gly Phe  Asp Phe Leu His Tyr  Asp Val Lys Thr Gly  Asp Phe Ile 
    1280                 1285                 1290             


Leu His  Phe Lys Met Asn Arg  Asn Leu Ser Phe Gln  Arg Gly Leu 
    1295                 1300                 1305             


Pro Gly  Phe Met Pro Ala Trp  Asp Ile Val Phe Glu  Lys Asn Glu 
    1310                 1315                 1320             


Thr Gln  Phe Asp Ala Lys Gly  Thr Pro Phe Ile Ala  Gly Lys Arg 
    1325                 1330                 1335             


Ile Val  Pro Val Ile Glu Asn  His Arg Phe Thr Gly  Arg Tyr Arg 
    1340                 1345                 1350             


Asp Leu  Tyr Pro Ala Asn Glu  Leu Ile Ala Leu Leu  Glu Glu Lys 
    1355                 1360                 1365             


Gly Ile  Val Phe Arg Asp Gly  Ser Asn Ile Leu Pro  Lys Leu Leu 
    1370                 1375                 1380             


Glu Asn  Asp Asp Ser His Ala  Ile Asp Thr Met Val  Ala Leu Ile 
    1385                 1390                 1395             


Arg Ser  Val Leu Gln Met Arg  Asn Ser Asn Ala Ala  Thr Gly Glu 
    1400                 1405                 1410             


Asp Tyr  Ile Asn Ser Pro Val  Arg Asp Leu Asn Gly  Val Cys Phe 
    1415                 1420                 1425             


Asp Ser  Arg Phe Gln Asn Pro  Glu Trp Pro Met Asp  Ala Asp Ala 
    1430                 1435                 1440             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Gln Leu  Leu Leu Asn 
    1445                 1450                 1455             


His Leu  Lys Glu Ser Lys Asp  Leu Lys Leu Gln Asn  Gly Ile Ser 
    1460                 1465                 1470             


Asn Gln  Asp Trp Leu Ala Tyr  Ile Gln Glu Leu Arg  Asn 
    1475                 1480                 1485     


<210> 49
<211> 1156
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 49
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr 
                85                  90                  95      


Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys 
            100                 105                 110         


Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp 
        115                 120                 125             


Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp 
    130                 135                 140                 


Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr 
145                 150                 155                 160 


Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser Gly Gly Thr 
                165                 170                 175     


Gly Gly Ser Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu 
            180                 185                 190         


Val Lys Asp Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys 
        195                 200                 205             


Thr Leu Leu Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu 
    210                 215                 220                 


Asn Leu Arg Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr 
225                 230                 235                 240 


Ser Arg Ala Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys 
                245                 250                 255     


Lys Ala Ile Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val 
            260                 265                 270         


Gly Leu Met Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln 
        275                 280                 285             


Arg Lys Leu Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser 
    290                 295                 300                 


Gly Phe Ala Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu 
305                 310                 315                 320 


Glu Gln Val Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg 
                325                 330                 335     


Cys Asn Val Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys 
            340                 345                 350         


Pro Glu Ala Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly 
        355                 360                 365             


Gln Arg Ala Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn 
    370                 375                 380                 


His Pro Val Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser 
385                 390                 395                 400 


Gly Pro Val Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala 
                405                 410                 415     


Ser Phe Leu Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val 
            420                 425                 430         


Ile Lys Lys Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser 
        435                 440                 445             


Ala Asn Gly Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His 
    450                 455                 460                 


Thr Lys Glu Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val 
465                 470                 475                 480 


Ile Trp Val Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp 
                485                 490                 495     


Glu Ala Lys Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu 
            500                 505                 510         


Val Glu Arg Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn 
        515                 520                 525             


Val Lys Lys Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp 
    530                 535                 540                 


Gln Asn Leu Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu 
545                 550                 555                 560 


Ser Ser Glu Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln 
                565                 570                 575     


Phe Gly Asp Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp 
            580                 585                 590         


Gly Lys Val Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu 
        595                 600                 605             


Gly Leu Ser Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp 
    610                 615                 620                 


Ala Gln Ser Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser 
625                 630                 635                 640 


Phe Val Ile Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg 
                645                 650                 655     


Cys Glu Leu Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro 
            660                 665                 670         


Phe Ala Ile Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser 
        675                 680                 685             


Lys Gln Tyr Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys 
    690                 695                 700                 


Leu Asn Leu Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg 
705                 710                 715                 720 


Phe Lys Lys Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr 
                725                 730                 735     


Val Ile Asn Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe 
            740                 745                 750         


Asn Phe Asp Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys 
        755                 760                 765             


Arg Gln Gly Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr 
    770                 775                 780                 


Gly Ser Leu Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr 
785                 790                 795                 800 


Asn Arg Arg Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr 
                805                 810                 815     


Phe Glu Arg Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn 
            820                 825                 830         


Leu Ile Gly Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu 
        835                 840                 845             


Thr Asp Pro Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly 
    850                 855                 860                 


Asn Pro Thr His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln 
865                 870                 875                 880 


Arg Thr Ile Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly 
                885                 890                 895     


Tyr Ser Arg Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met 
            900                 905                 910         


Val Arg Asn Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp 
        915                 920                 925             


Ala Met Leu Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly 
    930                 935                 940                 


Lys Arg Thr Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp 
945                 950                 955                 960 


Leu Thr Ala Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu 
                965                 970                 975     


Ser Lys Thr Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly 
            980                 985                 990         


Phe Thr Ile Thr Ser Ala Asp Tyr  Asp Arg Val Leu Glu  Lys Leu Lys 
        995                 1000                 1005             


Lys Thr  Ala Thr Gly Trp Met  Thr Thr Ile Asn Gly  Lys Glu Leu 
    1010                 1015                 1020             


Lys Val  Glu Gly Gln Ile Thr  Tyr Tyr Asn Arg Tyr  Lys Arg Gln 
    1025                 1030                 1035             


Asn Val  Val Lys Asp Leu Ser  Val Glu Leu Asp Arg  Leu Ser Glu 
    1040                 1045                 1050             


Glu Ser  Val Asn Asn Asp Ile  Ser Ser Trp Thr Lys  Gly Arg Ser 
    1055                 1060                 1065             


Gly Glu  Ala Leu Ser Leu Leu  Lys Lys Arg Phe Ser  His Arg Pro 
    1070                 1075                 1080             


Val Gln  Glu Lys Phe Val Cys  Leu Asn Cys Gly Phe  Glu Thr His 
    1085                 1090                 1095             


Ala Asp  Glu Gln Ala Ala Leu  Asn Ile Ala Arg Ser  Trp Leu Phe 
    1100                 1105                 1110             


Leu Arg  Ser Gln Glu Tyr Lys  Lys Tyr Gln Thr Asn  Lys Thr Thr 
    1115                 1120                 1125             


Gly Asn  Thr Asp Lys Arg Ala  Phe Val Glu Thr Trp  Gln Ser Phe 
    1130                 1135                 1140             


Tyr Arg  Lys Lys Leu Lys Glu  Val Trp Lys Pro Ala  Val 
    1145                 1150                 1155     


<210> 50
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 50
uaauuucuac ucuuguagau                                                   20


<210> 51
<211> 1306
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Cas12a sequence

<400> 51
Thr Gln Phe Glu Gly Phe Thr Asn Leu Tyr Gln Val Ser Lys Thr Leu 
1               5                   10                  15      


Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Lys His Ile Gln Glu 
            20                  25                  30          


Gln Gly Phe Ile Glu Glu Asp Lys Ala Arg Asn Asp His Tyr Lys Glu 
        35                  40                  45              


Leu Lys Pro Ile Ile Asp Arg Ile Tyr Lys Thr Tyr Ala Asp Gln Cys 
    50                  55                  60                  


Leu Gln Leu Val Gln Leu Asp Trp Glu Asn Leu Ser Ala Ala Ile Asp 
65                  70                  75                  80  


Ser Tyr Arg Lys Glu Lys Thr Glu Glu Thr Arg Asn Ala Leu Ile Glu 
                85                  90                  95      


Glu Gln Ala Thr Tyr Arg Asn Ala Ile His Asp Tyr Phe Ile Gly Arg 
            100                 105                 110         


Thr Asp Asn Leu Thr Asp Ala Ile Asn Lys Arg His Ala Glu Ile Tyr 
        115                 120                 125             


Lys Gly Leu Phe Lys Ala Glu Leu Phe Asn Gly Lys Val Leu Lys Gln 
    130                 135                 140                 


Leu Gly Thr Val Thr Thr Thr Glu His Glu Asn Ala Leu Leu Arg Ser 
145                 150                 155                 160 


Phe Asp Lys Phe Thr Thr Tyr Phe Ser Gly Phe Tyr Glu Asn Arg Lys 
                165                 170                 175     


Asn Val Phe Ser Ala Glu Asp Ile Ser Thr Ala Ile Pro His Arg Ile 
            180                 185                 190         


Val Gln Asp Asn Phe Pro Lys Phe Lys Glu Asn Cys His Ile Phe Thr 
        195                 200                 205             


Arg Leu Ile Thr Ala Val Pro Ser Leu Arg Glu His Phe Glu Asn Val 
    210                 215                 220                 


Lys Lys Ala Ile Gly Ile Phe Val Ser Thr Ser Ile Glu Glu Val Phe 
225                 230                 235                 240 


Ser Phe Pro Phe Tyr Asn Gln Leu Leu Thr Gln Thr Gln Ile Asp Leu 
                245                 250                 255     


Tyr Asn Gln Leu Leu Gly Gly Ile Ser Arg Glu Ala Gly Thr Glu Lys 
            260                 265                 270         


Ile Lys Gly Leu Asn Glu Val Leu Asn Leu Ala Ile Gln Lys Asn Asp 
        275                 280                 285             


Glu Thr Ala His Ile Ile Ala Ser Leu Pro His Arg Phe Ile Pro Leu 
    290                 295                 300                 


Phe Lys Gln Ile Leu Ser Asp Arg Asn Thr Leu Ser Phe Ile Leu Glu 
305                 310                 315                 320 


Glu Phe Lys Ser Asp Glu Glu Val Ile Gln Ser Phe Cys Lys Tyr Lys 
                325                 330                 335     


Thr Leu Leu Arg Asn Glu Asn Val Leu Glu Thr Ala Glu Ala Leu Phe 
            340                 345                 350         


Asn Glu Leu Asn Ser Ile Asp Leu Thr His Ile Phe Ile Ser His Lys 
        355                 360                 365             


Lys Leu Glu Thr Ile Ser Ser Ala Leu Cys Asp His Trp Asp Thr Leu 
    370                 375                 380                 


Arg Asn Ala Leu Tyr Glu Arg Arg Ile Ser Glu Leu Thr Gly Lys Ile 
385                 390                 395                 400 


Thr Lys Ser Ala Lys Glu Lys Val Gln Arg Ser Leu Lys His Glu Asp 
                405                 410                 415     


Ile Asn Leu Gln Glu Ile Ile Ser Ala Ala Gly Lys Glu Leu Ser Glu 
            420                 425                 430         


Ala Phe Lys Gln Lys Thr Ser Glu Ile Leu Ser His Ala His Ala Ala 
        435                 440                 445             


Leu Asp Gln Pro Leu Pro Thr Thr Leu Lys Lys Gln Glu Glu Lys Glu 
    450                 455                 460                 


Ile Leu Lys Ser Gln Leu Asp Ser Leu Leu Gly Leu Tyr His Leu Leu 
465                 470                 475                 480 


Asp Trp Phe Ala Val Asp Glu Ser Asn Glu Val Asp Pro Glu Phe Ser 
                485                 490                 495     


Ala Arg Leu Thr Gly Ile Lys Leu Glu Met Glu Pro Ser Leu Ser Phe 
            500                 505                 510         


Tyr Asn Lys Ala Arg Asn Tyr Ala Thr Lys Lys Pro Tyr Ser Val Glu 
        515                 520                 525             


Lys Phe Lys Leu Asn Phe Gln Met Pro Thr Leu Ala Ser Gly Trp Asp 
    530                 535                 540                 


Val Asn Lys Glu Lys Asn Asn Gly Ala Ile Leu Phe Val Lys Asn Gly 
545                 550                 555                 560 


Leu Tyr Tyr Leu Gly Ile Met Pro Lys Gln Lys Gly Arg Tyr Lys Ala 
                565                 570                 575     


Leu Ser Phe Glu Pro Thr Glu Lys Thr Ser Glu Gly Phe Asp Lys Met 
            580                 585                 590         


Tyr Tyr Asp Tyr Phe Pro Asp Ala Ala Lys Met Ile Pro Lys Cys Ser 
        595                 600                 605             


Thr Gln Leu Lys Ala Val Thr Ala His Phe Gln Thr His Thr Thr Pro 
    610                 615                 620                 


Ile Leu Leu Ser Asn Asn Phe Ile Glu Pro Leu Glu Ile Thr Lys Glu 
625                 630                 635                 640 


Ile Tyr Asp Leu Asn Asn Pro Glu Lys Glu Pro Lys Lys Phe Gln Thr 
                645                 650                 655     


Ala Tyr Ala Lys Lys Thr Gly Asp Gln Lys Gly Tyr Arg Glu Ala Leu 
            660                 665                 670         


Cys Lys Trp Ile Asp Phe Thr Arg Asp Phe Leu Ser Lys Tyr Thr Lys 
        675                 680                 685             


Thr Thr Ser Ile Asp Leu Ser Ser Leu Arg Pro Ser Ser Gln Tyr Lys 
    690                 695                 700                 


Asp Leu Gly Glu Tyr Tyr Ala Glu Leu Asn Pro Leu Leu Tyr His Ile 
705                 710                 715                 720 


Ser Phe Gln Arg Ile Ala Glu Lys Glu Ile Met Asp Ala Val Glu Thr 
                725                 730                 735     


Gly Lys Leu Tyr Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ala Lys Gly 
            740                 745                 750         


His His Gly Lys Pro Asn Leu His Thr Leu Tyr Trp Thr Gly Leu Phe 
        755                 760                 765             


Ser Pro Glu Asn Leu Ala Lys Thr Ser Ile Lys Leu Asn Gly Gln Ala 
    770                 775                 780                 


Glu Leu Phe Tyr Arg Pro Lys Ser Arg Met Lys Arg Met Ala His Arg 
785                 790                 795                 800 


Leu Gly Glu Lys Met Leu Asn Lys Lys Leu Lys Asp Gln Lys Thr Pro 
                805                 810                 815     


Ile Pro Asp Thr Leu Tyr Gln Glu Leu Tyr Asp Tyr Val Asn His Arg 
            820                 825                 830         


Leu Ser His Asp Leu Ser Asp Glu Ala Arg Ala Leu Leu Pro Asn Val 
        835                 840                 845             


Ile Thr Lys Glu Val Ser His Glu Ile Ile Lys Asp Arg Arg Phe Thr 
    850                 855                 860                 


Ser Asp Lys Phe Phe Phe His Val Pro Ile Thr Leu Asn Tyr Gln Ala 
865                 870                 875                 880 


Ala Asn Ser Pro Ser Lys Phe Asn Gln Arg Val Asn Ala Tyr Leu Lys 
                885                 890                 895     


Glu His Pro Glu Thr Pro Ile Ile Gly Ile Asp Arg Gly Glu Arg Asn 
            900                 905                 910         


Leu Ile Tyr Ile Thr Val Ile Asp Ser Thr Gly Lys Ile Leu Glu Gln 
        915                 920                 925             


Arg Ser Leu Asn Thr Ile Gln Gln Phe Asp Tyr Gln Lys Lys Leu Asp 
    930                 935                 940                 


Asn Arg Glu Lys Glu Arg Val Ala Ala Arg Gln Ala Trp Ser Val Val 
945                 950                 955                 960 


Gly Thr Ile Lys Asp Leu Lys Gln Gly Tyr Leu Ser Gln Val Ile His 
                965                 970                 975     


Glu Ile Val Asp Leu Met Ile His Tyr Gln Ala Val Val Val Leu Glu 
            980                 985                 990         


Asn Leu Asn Phe Gly Phe Lys Ser  Lys Arg Thr Gly Ile  Ala Glu Lys 
        995                 1000                 1005             


Ala Val  Tyr Gln Gln Phe Glu  Lys Met Leu Ile Asp  Lys Leu Asn 
    1010                 1015                 1020             


Cys Leu  Val Leu Lys Asp Tyr  Pro Ala Glu Lys Val  Gly Gly Val 
    1025                 1030                 1035             


Leu Asn  Pro Tyr Gln Leu Thr  Asp Gln Phe Thr Ser  Phe Ala Lys 
    1040                 1045                 1050             


Met Gly  Thr Gln Ser Gly Phe  Leu Phe Tyr Val Pro  Ala Pro Tyr 
    1055                 1060                 1065             


Thr Ser  Lys Ile Asp Pro Leu  Thr Gly Phe Val Asp  Pro Phe Val 
    1070                 1075                 1080             


Trp Lys  Thr Ile Lys Asn His  Glu Ser Arg Lys His  Phe Leu Glu 
    1085                 1090                 1095             


Gly Phe  Asp Phe Leu His Tyr  Asp Val Lys Thr Gly  Asp Phe Ile 
    1100                 1105                 1110             


Leu His  Phe Lys Met Asn Arg  Asn Leu Ser Phe Gln  Arg Gly Leu 
    1115                 1120                 1125             


Pro Gly  Phe Met Pro Ala Trp  Asp Ile Val Phe Glu  Lys Asn Glu 
    1130                 1135                 1140             


Thr Gln  Phe Asp Ala Lys Gly  Thr Pro Phe Ile Ala  Gly Lys Arg 
    1145                 1150                 1155             


Ile Val  Pro Val Ile Glu Asn  His Arg Phe Thr Gly  Arg Tyr Arg 
    1160                 1165                 1170             


Asp Leu  Tyr Pro Ala Asn Glu  Leu Ile Ala Leu Leu  Glu Glu Lys 
    1175                 1180                 1185             


Gly Ile  Val Phe Arg Asp Gly  Ser Asn Ile Leu Pro  Lys Leu Leu 
    1190                 1195                 1200             


Glu Asn  Asp Asp Ser His Ala  Ile Asp Thr Met Val  Ala Leu Ile 
    1205                 1210                 1215             


Arg Ser  Val Leu Gln Met Arg  Asn Ser Asn Ala Ala  Thr Gly Glu 
    1220                 1225                 1230             


Asp Tyr  Ile Asn Ser Pro Val  Arg Asp Leu Asn Gly  Val Cys Phe 
    1235                 1240                 1245             


Asp Ser  Arg Phe Gln Asn Pro  Glu Trp Pro Met Asp  Ala Asp Ala 
    1250                 1255                 1260             


Asn Gly  Ala Tyr His Ile Ala  Leu Lys Gly Gln Leu  Leu Leu Asn 
    1265                 1270                 1275             


His Leu  Lys Glu Ser Lys Asp  Leu Lys Leu Gln Asn  Gly Ile Ser 
    1280                 1285                 1290             


Asn Gln  Asp Trp Leu Ala Tyr  Ile Gln Glu Leu Arg  Asn 
    1295                 1300                 1305     


<210> 52
<211> 977
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CasX sequence

<400> 52
Gln Glu Ile Lys Arg Ile Asn Lys Ile Arg Arg Arg Leu Val Lys Asp 
1               5                   10                  15      


Ser Asn Thr Lys Lys Ala Gly Lys Thr Gly Pro Met Lys Thr Leu Leu 
            20                  25                  30          


Val Arg Val Met Thr Pro Asp Leu Arg Glu Arg Leu Glu Asn Leu Arg 
        35                  40                  45              


Lys Lys Pro Glu Asn Ile Pro Gln Pro Ile Ser Asn Thr Ser Arg Ala 
    50                  55                  60                  


Asn Leu Asn Lys Leu Leu Thr Asp Tyr Thr Glu Met Lys Lys Ala Ile 
65                  70                  75                  80  


Leu His Val Tyr Trp Glu Glu Phe Gln Lys Asp Pro Val Gly Leu Met 
                85                  90                  95      


Ser Arg Val Ala Gln Pro Ala Pro Lys Asn Ile Asp Gln Arg Lys Leu 
            100                 105                 110         


Ile Pro Val Lys Asp Gly Asn Glu Arg Leu Thr Ser Ser Gly Phe Ala 
        115                 120                 125             


Cys Ser Gln Cys Cys Gln Pro Leu Tyr Val Tyr Lys Leu Glu Gln Val 
    130                 135                 140                 


Asn Asp Lys Gly Lys Pro His Thr Asn Tyr Phe Gly Arg Cys Asn Val 
145                 150                 155                 160 


Ser Glu His Glu Arg Leu Ile Leu Leu Ser Pro His Lys Pro Glu Ala 
                165                 170                 175     


Asn Asp Glu Leu Val Thr Tyr Ser Leu Gly Lys Phe Gly Gln Arg Ala 
            180                 185                 190         


Leu Asp Phe Tyr Ser Ile His Val Thr Arg Glu Ser Asn His Pro Val 
        195                 200                 205             


Lys Pro Leu Glu Gln Ile Gly Gly Asn Ser Cys Ala Ser Gly Pro Val 
    210                 215                 220                 


Gly Lys Ala Leu Ser Asp Ala Cys Met Gly Ala Val Ala Ser Phe Leu 
225                 230                 235                 240 


Thr Lys Tyr Gln Asp Ile Ile Leu Glu His Gln Lys Val Ile Lys Lys 
                245                 250                 255     


Asn Glu Lys Arg Leu Ala Asn Leu Lys Asp Ile Ala Ser Ala Asn Gly 
            260                 265                 270         


Leu Ala Phe Pro Lys Ile Thr Leu Pro Pro Gln Pro His Thr Lys Glu 
        275                 280                 285             


Gly Ile Glu Ala Tyr Asn Asn Val Val Ala Gln Ile Val Ile Trp Val 
    290                 295                 300                 


Asn Leu Asn Leu Trp Gln Lys Leu Lys Ile Gly Arg Asp Glu Ala Lys 
305                 310                 315                 320 


Pro Leu Gln Arg Leu Lys Gly Phe Pro Ser Phe Pro Leu Val Glu Arg 
                325                 330                 335     


Gln Ala Asn Glu Val Asp Trp Trp Asp Met Val Cys Asn Val Lys Lys 
            340                 345                 350         


Leu Ile Asn Glu Lys Lys Glu Asp Gly Lys Val Phe Trp Gln Asn Leu 
        355                 360                 365             


Ala Gly Tyr Lys Arg Gln Glu Ala Leu Leu Pro Tyr Leu Ser Ser Glu 
    370                 375                 380                 


Glu Asp Arg Lys Lys Gly Lys Lys Phe Ala Arg Tyr Gln Phe Gly Asp 
385                 390                 395                 400 


Leu Leu Leu His Leu Glu Lys Lys His Gly Glu Asp Trp Gly Lys Val 
                405                 410                 415     


Tyr Asp Glu Ala Trp Glu Arg Ile Asp Lys Lys Val Glu Gly Leu Ser 
            420                 425                 430         


Lys His Ile Lys Leu Glu Glu Glu Arg Arg Ser Glu Asp Ala Gln Ser 
        435                 440                 445             


Lys Ala Ala Leu Thr Asp Trp Leu Arg Ala Lys Ala Ser Phe Val Ile 
    450                 455                 460                 


Glu Gly Leu Lys Glu Ala Asp Lys Asp Glu Phe Cys Arg Cys Glu Leu 
465                 470                 475                 480 


Lys Leu Gln Lys Trp Tyr Gly Asp Leu Arg Gly Lys Pro Phe Ala Ile 
                485                 490                 495     


Glu Ala Glu Asn Ser Ile Leu Asp Ile Ser Gly Phe Ser Lys Gln Tyr 
            500                 505                 510         


Asn Cys Ala Phe Ile Trp Gln Lys Asp Gly Val Lys Lys Leu Asn Leu 
        515                 520                 525             


Tyr Leu Ile Ile Asn Tyr Phe Lys Gly Gly Lys Leu Arg Phe Lys Lys 
    530                 535                 540                 


Ile Lys Pro Glu Ala Phe Glu Ala Asn Arg Phe Tyr Thr Val Ile Asn 
545                 550                 555                 560 


Lys Lys Ser Gly Glu Ile Val Pro Met Glu Val Asn Phe Asn Phe Asp 
                565                 570                 575     


Asp Pro Asn Leu Ile Ile Leu Pro Leu Ala Phe Gly Lys Arg Gln Gly 
            580                 585                 590         


Arg Glu Phe Ile Trp Asn Asp Leu Leu Ser Leu Glu Thr Gly Ser Leu 
        595                 600                 605             


Lys Leu Ala Asn Gly Arg Val Ile Glu Lys Thr Leu Tyr Asn Arg Arg 
    610                 615                 620                 


Thr Arg Gln Asp Glu Pro Ala Leu Phe Val Ala Leu Thr Phe Glu Arg 
625                 630                 635                 640 


Arg Glu Val Leu Asp Ser Ser Asn Ile Lys Pro Met Asn Leu Ile Gly 
                645                 650                 655     


Ile Asp Arg Gly Glu Asn Ile Pro Ala Val Ile Ala Leu Thr Asp Pro 
            660                 665                 670         


Glu Gly Cys Pro Leu Ser Arg Phe Lys Asp Ser Leu Gly Asn Pro Thr 
        675                 680                 685             


His Ile Leu Arg Ile Gly Glu Ser Tyr Lys Glu Lys Gln Arg Thr Ile 
    690                 695                 700                 


Gln Ala Ala Lys Glu Val Glu Gln Arg Arg Ala Gly Gly Tyr Ser Arg 
705                 710                 715                 720 


Lys Tyr Ala Ser Lys Ala Lys Asn Leu Ala Asp Asp Met Val Arg Asn 
                725                 730                 735     


Thr Ala Arg Asp Leu Leu Tyr Tyr Ala Val Thr Gln Asp Ala Met Leu 
            740                 745                 750         


Ile Phe Glu Asn Leu Ser Arg Gly Phe Gly Arg Gln Gly Lys Arg Thr 
        755                 760                 765             


Phe Met Ala Glu Arg Gln Tyr Thr Arg Met Glu Asp Trp Leu Thr Ala 
    770                 775                 780                 


Lys Leu Ala Tyr Glu Gly Leu Pro Ser Lys Thr Tyr Leu Ser Lys Thr 
785                 790                 795                 800 


Leu Ala Gln Tyr Thr Ser Lys Thr Cys Ser Asn Cys Gly Phe Thr Ile 
                805                 810                 815     


Thr Ser Ala Asp Tyr Asp Arg Val Leu Glu Lys Leu Lys Lys Thr Ala 
            820                 825                 830         


Thr Gly Trp Met Thr Thr Ile Asn Gly Lys Glu Leu Lys Val Glu Gly 
        835                 840                 845             


Gln Ile Thr Tyr Tyr Asn Arg Tyr Lys Arg Gln Asn Val Val Lys Asp 
    850                 855                 860                 


Leu Ser Val Glu Leu Asp Arg Leu Ser Glu Glu Ser Val Asn Asn Asp 
865                 870                 875                 880 


Ile Ser Ser Trp Thr Lys Gly Arg Ser Gly Glu Ala Leu Ser Leu Leu 
                885                 890                 895     


Lys Lys Arg Phe Ser His Arg Pro Val Gln Glu Lys Phe Val Cys Leu 
            900                 905                 910         


Asn Cys Gly Phe Glu Thr His Ala Asp Glu Gln Ala Ala Leu Asn Ile 
        915                 920                 925             


Ala Arg Ser Trp Leu Phe Leu Arg Ser Gln Glu Tyr Lys Lys Tyr Gln 
    930                 935                 940                 


Thr Asn Lys Thr Thr Gly Asn Thr Asp Lys Arg Ala Phe Val Glu Thr 
945                 950                 955                 960 


Trp Gln Ser Phe Tyr Arg Lys Lys Leu Lys Glu Val Trp Lys Pro Ala 
                965                 970                 975     


Val 
    


<210> 53
<211> 169
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      I-TevI nuclease domain and linker domain sequence

<400> 53
Met Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys Val 
1               5                   10                  15      


Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His Phe 
            20                  25                  30          


Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg Ser 
        35                  40                  45              


Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu Ile 
    50                  55                  60                  


Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile Lys 
65                  70                  75                  80  


Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala Asp Ala Thr Phe 
                85                  90                  95      


Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu Ile Ile Lys Lys 
            100                 105                 110         


Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu Gly Pro Asp Gly 
        115                 120                 125             


Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn Gly Arg Trp Asn 
    130                 135                 140                 


Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg Ile Gln Thr Ser 
145                 150                 155                 160 


Ala Tyr Thr Cys Ser Lys Cys Arg Asn 
                165                 


<210> 54
<211> 1052
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      CAS9 sequence

<400> 54
Lys Arg Asn Tyr Ile Leu Gly Leu Asp Ile Gly Ile Thr Ser Val Gly 
1               5                   10                  15      


Tyr Gly Ile Ile Asp Tyr Glu Thr Arg Asp Val Ile Asp Ala Gly Val 
            20                  25                  30          


Arg Leu Phe Lys Glu Ala Asn Val Glu Asn Asn Glu Gly Arg Arg Ser 
        35                  40                  45              


Lys Arg Gly Ala Arg Arg Leu Lys Arg Arg Arg Arg His Arg Ile Gln 
    50                  55                  60                  


Arg Val Lys Lys Leu Leu Phe Asp Tyr Asn Leu Leu Thr Asp His Ser 
65                  70                  75                  80  


Glu Leu Ser Gly Ile Asn Pro Tyr Glu Ala Arg Val Lys Gly Leu Ser 
                85                  90                  95      


Gln Lys Leu Ser Glu Glu Glu Phe Ser Ala Ala Leu Leu His Leu Ala 
            100                 105                 110         


Lys Arg Arg Gly Val His Asn Val Asn Glu Val Glu Glu Asp Thr Gly 
        115                 120                 125             


Asn Glu Leu Ser Thr Lys Glu Gln Ile Ser Arg Asn Ser Lys Ala Leu 
    130                 135                 140                 


Glu Glu Lys Tyr Val Ala Glu Leu Gln Leu Glu Arg Leu Lys Lys Asp 
145                 150                 155                 160 


Gly Glu Val Arg Gly Ser Ile Asn Arg Phe Lys Thr Ser Asp Tyr Val 
                165                 170                 175     


Lys Glu Ala Lys Gln Leu Leu Lys Val Gln Lys Ala Tyr His Gln Leu 
            180                 185                 190         


Asp Gln Ser Phe Ile Asp Thr Tyr Ile Asp Leu Leu Glu Thr Arg Arg 
        195                 200                 205             


Thr Tyr Tyr Glu Gly Pro Gly Glu Gly Ser Pro Phe Gly Trp Lys Asp 
    210                 215                 220                 


Ile Lys Glu Trp Tyr Glu Met Leu Met Gly His Cys Thr Tyr Phe Pro 
225                 230                 235                 240 


Glu Glu Leu Arg Ser Val Lys Tyr Ala Tyr Asn Ala Asp Leu Tyr Asn 
                245                 250                 255     


Ala Leu Asn Asp Leu Asn Asn Leu Val Ile Thr Arg Asp Glu Asn Glu 
            260                 265                 270         


Lys Leu Glu Tyr Tyr Glu Lys Phe Gln Ile Ile Glu Asn Val Phe Lys 
        275                 280                 285             


Gln Lys Lys Lys Pro Thr Leu Lys Gln Ile Ala Lys Glu Ile Leu Val 
    290                 295                 300                 


Asn Glu Glu Asp Ile Lys Gly Tyr Arg Val Thr Ser Thr Gly Lys Pro 
305                 310                 315                 320 


Glu Phe Thr Asn Leu Lys Val Tyr His Asp Ile Lys Asp Ile Thr Ala 
                325                 330                 335     


Arg Lys Glu Ile Ile Glu Asn Ala Glu Leu Leu Asp Gln Ile Ala Lys 
            340                 345                 350         


Ile Leu Thr Ile Tyr Gln Ser Ser Glu Asp Ile Gln Glu Glu Leu Thr 
        355                 360                 365             


Asn Leu Asn Ser Glu Leu Thr Gln Glu Glu Ile Glu Gln Ile Ser Asn 
    370                 375                 380                 


Leu Lys Gly Tyr Thr Gly Thr His Asn Leu Ser Leu Lys Ala Ile Asn 
385                 390                 395                 400 


Leu Ile Leu Asp Glu Leu Trp His Thr Asn Asp Asn Gln Ile Ala Ile 
                405                 410                 415     


Phe Asn Arg Leu Lys Leu Val Pro Lys Lys Val Asp Leu Ser Gln Gln 
            420                 425                 430         


Lys Glu Ile Pro Thr Thr Leu Val Asp Asp Phe Ile Leu Ser Pro Val 
        435                 440                 445             


Val Lys Arg Ser Phe Ile Gln Ser Ile Lys Val Ile Asn Ala Ile Ile 
    450                 455                 460                 


Lys Lys Tyr Gly Leu Pro Asn Asp Ile Ile Ile Glu Leu Ala Arg Glu 
465                 470                 475                 480 


Lys Asn Ser Lys Asp Ala Gln Lys Met Ile Asn Glu Met Gln Lys Arg 
                485                 490                 495     


Asn Arg Gln Thr Asn Glu Arg Ile Glu Glu Ile Ile Arg Thr Thr Gly 
            500                 505                 510         


Lys Glu Asn Ala Lys Tyr Leu Ile Glu Lys Ile Lys Leu His Asp Met 
        515                 520                 525             


Gln Glu Gly Lys Cys Leu Tyr Ser Leu Glu Ala Ile Pro Leu Glu Asp 
    530                 535                 540                 


Leu Leu Asn Asn Pro Phe Asn Tyr Glu Val Asp His Ile Ile Pro Arg 
545                 550                 555                 560 


Ser Val Ser Phe Asp Asn Ser Phe Asn Asn Lys Val Leu Val Lys Gln 
                565                 570                 575     


Glu Glu Asn Ser Lys Lys Gly Asn Arg Thr Pro Phe Gln Tyr Leu Ser 
            580                 585                 590         


Ser Ser Asp Ser Lys Ile Ser Tyr Glu Thr Phe Lys Lys His Ile Leu 
        595                 600                 605             


Asn Leu Ala Lys Gly Lys Gly Arg Ile Ser Lys Thr Lys Lys Glu Tyr 
    610                 615                 620                 


Leu Leu Glu Glu Arg Asp Ile Asn Arg Phe Ser Val Gln Lys Asp Phe 
625                 630                 635                 640 


Ile Asn Arg Asn Leu Val Asp Thr Arg Tyr Ala Thr Arg Gly Leu Met 
                645                 650                 655     


Asn Leu Leu Arg Ser Tyr Phe Arg Val Asn Asn Leu Asp Val Lys Val 
            660                 665                 670         


Lys Ser Ile Asn Gly Gly Phe Thr Ser Phe Leu Arg Arg Lys Trp Lys 
        675                 680                 685             


Phe Lys Lys Glu Arg Asn Lys Gly Tyr Lys His His Ala Glu Asp Ala 
    690                 695                 700                 


Leu Ile Ile Ala Asn Ala Asp Phe Ile Phe Lys Glu Trp Lys Lys Leu 
705                 710                 715                 720 


Asp Lys Ala Lys Lys Val Met Glu Asn Gln Met Phe Glu Glu Lys Gln 
                725                 730                 735     


Ala Glu Ser Met Pro Glu Ile Glu Thr Glu Gln Glu Tyr Lys Glu Ile 
            740                 745                 750         


Phe Ile Thr Pro His Gln Ile Lys His Ile Lys Asp Phe Lys Asp Tyr 
        755                 760                 765             


Lys Tyr Ser His Arg Val Asp Lys Lys Pro Asn Arg Glu Leu Ile Asn 
    770                 775                 780                 


Asp Thr Leu Tyr Ser Thr Arg Lys Asp Asp Lys Gly Asn Thr Leu Ile 
785                 790                 795                 800 


Val Asn Asn Leu Asn Gly Leu Tyr Asp Lys Asp Asn Asp Lys Leu Lys 
                805                 810                 815     


Lys Leu Ile Asn Lys Ser Pro Glu Lys Leu Leu Met Tyr His His Asp 
            820                 825                 830         


Pro Gln Thr Tyr Gln Lys Leu Lys Leu Ile Met Glu Gln Tyr Gly Asp 
        835                 840                 845             


Glu Lys Asn Pro Leu Tyr Lys Tyr Tyr Glu Glu Thr Gly Asn Tyr Leu 
    850                 855                 860                 


Thr Lys Tyr Ser Lys Lys Asp Asn Gly Pro Val Ile Lys Lys Ile Lys 
865                 870                 875                 880 


Tyr Tyr Gly Asn Lys Leu Asn Ala His Leu Asp Ile Thr Asp Asp Tyr 
                885                 890                 895     


Pro Asn Ser Arg Asn Lys Val Val Lys Leu Ser Leu Lys Pro Tyr Arg 
            900                 905                 910         


Phe Asp Val Tyr Leu Asp Asn Gly Val Tyr Lys Phe Val Thr Val Lys 
        915                 920                 925             


Asn Leu Asp Val Ile Lys Lys Glu Asn Tyr Tyr Glu Val Asn Ser Lys 
    930                 935                 940                 


Cys Tyr Glu Glu Ala Lys Lys Leu Lys Lys Ile Ser Asn Gln Ala Glu 
945                 950                 955                 960 


Phe Ile Ala Ser Phe Tyr Asn Asn Asp Leu Ile Lys Ile Asn Gly Glu 
                965                 970                 975     


Leu Tyr Arg Val Ile Gly Val Asn Asn Asp Leu Leu Asn Arg Ile Glu 
            980                 985                 990         


Val Asn Met Ile Asp Ile Thr Tyr  Arg Glu Tyr Leu Glu  Asn Met Asn 
        995                 1000                 1005             


Asp Lys  Arg Pro Pro Arg Ile  Ile Lys Thr Ile Ala  Ser Lys Thr 
    1010                 1015                 1020             


Gln Ser  Ile Lys Lys Tyr Ser  Thr Asp Ile Leu Gly  Asn Leu Tyr 
    1025                 1030                 1035             


Glu Val  Lys Ser Lys Lys His  Pro Gln Ile Ile Lys  Lys Gly 
    1040                 1045                 1050         


<210> 55
<211> 7
<212> PRT
<213> Simian virus 40

<400> 55
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 56
<211> 16
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      Nucleoplasmin nuclear localization sequence

<400> 56
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 57
<211> 77
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      I-TevI linker fragment sequence

<400> 57
Asp Ala Thr Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu 
1               5                   10                  15      


Ile Ile Lys Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu 
            20                  25                  30          


Gly Pro Asp Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn 
        35                  40                  45              


Gly Arg Trp Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg 
    50                  55                  60                  


Ile Gln Thr Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn 
65                  70                  75          


<210> 58
<211> 93
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ITev-I nuclease domain sequence

<400> 58
Met Gly Lys Ser Gly Ile Tyr Gln Ile Lys Asn Thr Leu Asn Asn Lys 
1               5                   10                  15      


Val Tyr Val Gly Ser Ala Lys Asp Phe Glu Lys Arg Trp Lys Arg His 
            20                  25                  30          


Phe Lys Asp Leu Glu Lys Gly Cys His Ser Ser Ile Lys Leu Gln Arg 
        35                  40                  45              


Ser Phe Asn Lys His Gly Asn Val Phe Glu Cys Ser Ile Leu Glu Glu 
    50                  55                  60                  


Ile Pro Tyr Glu Lys Asp Leu Ile Ile Glu Arg Glu Asn Phe Trp Ile 
65                  70                  75                  80  


Lys Glu Leu Asn Ser Lys Ile Asn Gly Tyr Asn Ile Ala 
                85                  90              


<210> 59
<211> 83
<212> PRT
<213> Unknown

<220>
<223> Description of Unknown: 
      ITev-I linker domain sequence

<400> 59
Asp Ala Thr Phe Gly Asp Thr Cys Ser Thr His Pro Leu Lys Glu Glu 
1               5                   10                  15      


Ile Ile Lys Lys Arg Ser Glu Thr Val Lys Ala Lys Met Leu Lys Leu 
            20                  25                  30          


Gly Pro Asp Gly Arg Lys Ala Leu Tyr Ser Lys Pro Gly Ser Lys Asn 
        35                  40                  45              


Gly Arg Trp Asn Pro Glu Thr His Lys Phe Cys Lys Cys Gly Val Arg 
    50                  55                  60                  


Ile Gln Thr Ser Ala Tyr Thr Cys Ser Lys Cys Arg Asn Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Ser 
            


<210> 60
<211> 1709
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 60
ttagcgaggg ggcagggcct gcatgtgaag ggcgtcgtag gtgtccttgg tggctgtact       60

gagaccctgg taaaggccat cgtgcccctt gcccctccgg cgctcgcctt tcatcccaat      120

ctcactgtag gcctccgcca tcttatcttt ctgcagttca ttgtacaggc cttcctgagg      180

gttcttcctt ctcggctttc cccccatctc agggtcccgg ccacgtctct tgtccaaaac      240

atcgtactcc tctcttcgtc ctagattgag ctcgttatag agctggttct ggccctgctg      300

gtacgcgggg gcgtctgcgc tcctgctgaa cttcactctg gagcgatagg ctgcgaagtc      360

gcgtggtggg gcatagggct ggtaatgctt gcgggtgggc ccggggcggc ggggagtcat      420

gttcatgtag tcactgtgca ggagcctgct cctcttactc ctcacccaga aaataataaa      480

ggccactgtt actagcaagc tatagcaagc caggactccc ccaaccacca ccagcaccca      540

aaagggctta gaaggtccgg gaaatagggg acttggacaa aggtgtttcc ctttcacatg      600

gataatggtt ccattgctct tctcattgtc taggtaagga ggaggataca taacttcaat      660

tgcggccgct gaggagacgg tgactgaggt tccttgaccc cagtagtcca tagcatagct      720

accaccgtag taataatgtt tggcacagta gtaaatggct gtgtcatcag tttgcagact      780

gttcattttt aagaaaactt ggctcttgga gttgtccttg atgatggtca gtctggattt      840

gagagctgaa ttatagtatg tggtttcact accccatatt actcccagcc actccagacc      900

ctttcgtgga ggctggcgaa tccagcttac accatagtcg ggtaatgaga cccctgagac      960

agtgcatgtg acggacaggc tctgtgaggg cgccaccagg ccaggtcctg actcctgcag     1020

tttcacctcg cccttggtgg atccctcgcc agatccgggc ttgccggatc cagaggtgga     1080

gcctgttatt tccaacttag tcccccctcc gaacgtgtac ggaagcgtat taccctgttg     1140

gcaaaagtaa gtggcaatat cttcttgctc caggttgcta atggtgagag aataatctgt     1200

tccagaccca ctgccactga accttgatgg gactcctgag tgtaatcttg atgtatggta     1260

gatcaggagt ttaacagttc catctggttt ctgctgatac caatttaaat atttactaat     1320

gtcctgactt gccctgcaac tgatggtgac tctgtctccc agagaggcag acagggagga     1380

tgtagtctgt gtcatctgga tgtctgggat caggaggaat gctgggtgtg gtaactcaca     1440

gagcagaagg cttgtcacca ggagaagcat ggtggcggat cccgcgtcac gacacctgtg     1500

ttctggcggc aaacccgttg cgaaaaagaa cgttcacggc gactactgca cttatatacg     1560

gttctccccc accctcggga aaaaggcgga gccagtacac gacatcactt tcccagttta     1620

ccccgcgcca ccttctctag gcaccggttc aattgccgac ccctcccccc aacttctcgg     1680

ggactgtggg cgatgtgcgc tctgccccc                                       1709


<210> 61
<211> 71
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 61
agacgaatat aacttcgtat aatgtatgct atacgaagtt atagagaagg gaaagcaaag       60

atcttaagac c                                                            71


<210> 62
<211> 46
<212> DNA
<213> Homo sapiens

<400> 62
agagcagggt cccgcttccc taaggccctg ctctgggctt ctgggt                      46


<210> 63
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
accacatcat atcttggttg caagggcctg ggctgggctt ctgggt                      46


<210> 64
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 64
cccaggaacc atgcttccca ggctcccttg cccttggctt ctgggt                      46


<210> 65
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 65
actgggagct ggtgctgtat catgcccctg ctctgagatt ctgggt                      46


<210> 66
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
tgattgagct ttgcagcaaa tgttttcctt ctcttgactt ctgggt                      46


<210> 67
<211> 46
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
ataacatgta gcaattataa aaattacctt ctctgaactt ctgggt                      46


