                         SEQUENCE LISTING

<110>  Pfizer Inc.
 
<120>  METHODS FOR PURIFICATION OF AAV VECTORS BY ANION EXCHANGE 
       CHROMATOGRAPHY

<130>  PC072555A

<150>  63/253215
<151>  2021-10-07

<150>  63/217194
<151>  2021-06-30

<150>  63/109049
<151>  2020-11-03

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  3978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1
atgctttggt gggaggaagt ggaggactgc tacgagagag aggacgtgca gaagaaaacc       60

ttcaccaagt gggtgaacgc ccagttcagc aagttcggca agcagcacat cgagaacctg      120

ttcagcgacc tgcaggatgg caggagactg ctggacctgc tggagggcct gaccggccag      180

aagctgccca aggagaaggg cagcaccaga gtgcacgccc tgaacaacgt gaacaaggcc      240

ctgagagtgc tgcagaacaa caacgtggac ctggtgaaca tcggcagcac cgacatcgtg      300

gacggcaacc acaagctgac cctgggcctg atctggaaca tcatcctgca ctggcaggtg      360

aagaacgtga tgaagaacat catggccggc ctgcagcaga ccaacagcga gaagatcctg      420

ctgagctggg tgaggcagag caccagaaac tacccccagg tgaacgtgat caacttcacc      480

acctcctgga gcgacggcct ggccctgaac gccctgatcc acagccacag acccgacctg      540

ttcgactgga acagcgtggt gtgtcagcag agcgccaccc agagactgga gcacgccttc      600

aacatcgcca gataccagct gggcatcgag aagctgctgg accccgagga cgtggacacc      660

acctaccccg acaagaaaag catcctcatg tacattacca gcctgttcca ggtgctgccc      720

cagcaggtgt ccatcgaggc catccaggaa gtggaaatgc tgcccaggcc ccccaaagtg      780

accaaggagg agcacttcca gctgcaccac cagatgcact acagccagca gatcacagtg      840

agcctggccc agggctatga gagaaccagc agccccaagc ccagattcaa gagctacgcc      900

tacacccagg ccgcctacgt gaccacctcc gaccccacca gaagcccctt ccccagccag      960

cacctggagg cccccgagga caagagcttc ggcagcagcc tgatggagag cgaagtgaac     1020

ctggacagat accagaccgc cctggaggaa gtgctgtcct ggctgctgag cgccgaggac     1080

accctgcagg cccagggcga gatcagcaac gacgtggaag tggtgaagga ccagttccac     1140

acccacgagg gctacatgat ggatctgacc gcccaccagg gcagagtggg caatatcctg     1200

cagctgggca gcaagctgat cggcaccggc aagctgagcg aggacgagga gaccgaagtg     1260

caggagcaga tgaacctgct gaacagcaga tgggagtgcc tgagagtggc cagcatggag     1320

aagcagagca acctgcacag agtgctgatg gacctgcaga accagaagct gaaggagctg     1380

aacgactggc tgaccaagac cgaggagcgg accagaaaga tggaggagga gcccctgggc     1440

cccgacctgg aggacctgaa gagacaggtg cagcagcaca aagtgctgca ggaggacctg     1500

gagcaggagc aggtgcgcgt gaacagcctg acccacatgg tggtggtcgt ggacgagagc     1560

agcggcgacc acgccacagc cgccctggaa gagcagctga aagtgctggg cgacagatgg     1620

gccaatattt gtaggtggac cgaggacaga tgggtgctgc tgcaggacca gcccgacctg     1680

gcccctggcc tgaccaccat cggcgccagc cccacccaga ccgtgaccct ggtgacccag     1740

cccgtggtga caaaggagac cgccatcagc aagctggaga tgcccagctc cctgatgctg     1800

gaagtgccca cccaccgcct gctccagcag ttccccctgg acctggagaa gttcctggcc     1860

tggctgaccg aggccgaaac caccgccaat gtgctccagg acgccactag aaaggagagg     1920

ctgctggagg acagcaaggg cgtgaaagag ctgatgaagc agtggcagga tctgcagggc     1980

gaaatcgagg cccacaccga cgtgtaccac aacctggacg agaacagcca gaagattctg     2040

aggagcctgg agggcagcga cgacgccgtc ctgctccaga ggaggctgga caacatgaac     2100

ttcaagtgga gcgagctgcg gaagaagagc ctgaacatcc ggagccacct ggaagccagc     2160

agcgaccagt ggaagagact gcacctgagc ctgcaggagc tgctggtgtg gctgcagctg     2220

aaggacgacg agctgagcag acaggccccc atcggcggcg acttccccgc cgtgcagaag     2280

cagaacgacg tgcaccgggc cttcaagagg gagctgaaaa ccaaggaacc cgtgatcatg     2340

agcaccctgg agacagtgcg gatcttcctg accgagcagc ccctggaggg actggagaag     2400

ctgtaccagg agcccagaga gctgcccccc gaggagagag cccagaacgt gaccaggctg     2460

ctgagaaagc aggccgagga agtgaatacc gagtgggaga agctgaatct gcacagcgcc     2520

gactggcaga gaaagatcga cgagaccctg gagagactcc aggaactgca ggaagccacc     2580

gacgagctgg acctgaagct gagacaggcc gaagtgatca agggcagctg gcagcctgtg     2640

ggcgatctgc tgatcgactc cctgcaggat cacctggaga aagtgaaggc cctgcggggc     2700

gagatcgccc ccctgaagga gaatgtgagc cacgtgaacg acctggccag acagctgacc     2760

accctgggca tccagctgag cccctacaac ctgagcacac tggaggatct gaacacccgg     2820

tggaaactgc tgcaggtggc cgtggaggat agagtgaggc agctgcacga agcccacaga     2880

gacttcggcc ctgcctccca gcacttcctg agcaccagcg tgcagggccc ctgggagaga     2940

gccatctccc ccaacaaagt gccctactac atcaaccacg agacccagac cacctgctgg     3000

gaccacccta agatgaccga gctgtatcag agcctggccg acctgaacaa tgtgcggttc     3060

agcgcctaca gaaccgccat gaagctgcgg agactgcaga aggccctgtg cctggatctg     3120

ctgagcctga gcgccgcctg cgacgccctg gaccagcaca acctgaagca gaatgaccag     3180

cccatggaca tcctgcagat catcaactgc ctgaccacaa tctacgaccg gctggaacag     3240

gagcacaaca acctggtgaa tgtgcccctg tgcgtggaca tgtgcctgaa ttggctgctg     3300

aacgtgtacg acaccggcag gaccggcaga atccgcgtgc tgagcttcaa gaccggcatc     3360

atcagcctgt gcaaggccca cctggaggat aagtaccgct acctgttcaa gcaggtggcc     3420

agcagcaccg gcttctgcga tcagaggaga ctgggcctgc tgctgcacga tagcatccag     3480

atccctaggc agctgggcga agtggccagc tttggcggca gcaacatcga gccctctgtg     3540

aggagctgct tccagttcgc caacaacaag cccgagatcg aggccgccct gttcctggac     3600

tggatgaggc tggagcctca gagcatggtg tggctgcctg tgctgcacag agtggccgcc     3660

gccgagaccg ccaagcacca ggccaagtgc aatatctgca aggagtgccc catcatcggc     3720

ttccggtaca ggagcctgaa gcacttcaac tacgacatct gccagagctg ctttttcagc     3780

ggcagagtgg ccaagggcca caaaatgcac taccccatgg tggagtactg cacccccacc     3840

acctccggcg aggatgtgag agacttcgcc aaagtgctga agaataagtt ccggaccaag     3900

cggtactttg ccaagcaccc caggatgggc tacctgcccg tgcagaccgt gctggaaggc     3960

gacaacatgg agacctga                                                   3978


<210>  2
<211>  1325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Gln Pro Asp Leu 
545                 550                 555                 560 


Ala Pro Gly Leu Thr Thr Ile Gly Ala Ser Pro Thr Gln Thr Val Thr 
                565                 570                 575     


Leu Val Thr Gln Pro Val Val Thr Lys Glu Thr Ala Ile Ser Lys Leu 
            580                 585                 590         


Glu Met Pro Ser Ser Leu Met Leu Glu Val Pro Thr His Arg Leu Leu 
        595                 600                 605             


Gln Gln Phe Pro Leu Asp Leu Glu Lys Phe Leu Ala Trp Leu Thr Glu 
    610                 615                 620                 


Ala Glu Thr Thr Ala Asn Val Leu Gln Asp Ala Thr Arg Lys Glu Arg 
625                 630                 635                 640 


Leu Leu Glu Asp Ser Lys Gly Val Lys Glu Leu Met Lys Gln Trp Gln 
                645                 650                 655     


Asp Leu Gln Gly Glu Ile Glu Ala His Thr Asp Val Tyr His Asn Leu 
            660                 665                 670         


Asp Glu Asn Ser Gln Lys Ile Leu Arg Ser Leu Glu Gly Ser Asp Asp 
        675                 680                 685             


Ala Val Leu Leu Gln Arg Arg Leu Asp Asn Met Asn Phe Lys Trp Ser 
    690                 695                 700                 


Glu Leu Arg Lys Lys Ser Leu Asn Ile Arg Ser His Leu Glu Ala Ser 
705                 710                 715                 720 


Ser Asp Gln Trp Lys Arg Leu His Leu Ser Leu Gln Glu Leu Leu Val 
                725                 730                 735     


Trp Leu Gln Leu Lys Asp Asp Glu Leu Ser Arg Gln Ala Pro Ile Gly 
            740                 745                 750         


Gly Asp Phe Pro Ala Val Gln Lys Gln Asn Asp Val His Arg Ala Phe 
        755                 760                 765             


Lys Arg Glu Leu Lys Thr Lys Glu Pro Val Ile Met Ser Thr Leu Glu 
    770                 775                 780                 


Thr Val Arg Ile Phe Leu Thr Glu Gln Pro Leu Glu Gly Leu Glu Lys 
785                 790                 795                 800 


Leu Tyr Gln Glu Pro Arg Glu Leu Pro Pro Glu Glu Arg Ala Gln Asn 
                805                 810                 815     


Val Thr Arg Leu Leu Arg Lys Gln Ala Glu Glu Val Asn Thr Glu Trp 
            820                 825                 830         


Glu Lys Leu Asn Leu His Ser Ala Asp Trp Gln Arg Lys Ile Asp Glu 
        835                 840                 845             


Thr Leu Glu Arg Leu Gln Glu Leu Gln Glu Ala Thr Asp Glu Leu Asp 
    850                 855                 860                 


Leu Lys Leu Arg Gln Ala Glu Val Ile Lys Gly Ser Trp Gln Pro Val 
865                 870                 875                 880 


Gly Asp Leu Leu Ile Asp Ser Leu Gln Asp His Leu Glu Lys Val Lys 
                885                 890                 895     


Ala Leu Arg Gly Glu Ile Ala Pro Leu Lys Glu Asn Val Ser His Val 
            900                 905                 910         


Asn Asp Leu Ala Arg Gln Leu Thr Thr Leu Gly Ile Gln Leu Ser Pro 
        915                 920                 925             


Tyr Asn Leu Ser Thr Leu Glu Asp Leu Asn Thr Arg Trp Lys Leu Leu 
    930                 935                 940                 


Gln Val Ala Val Glu Asp Arg Val Arg Gln Leu His Glu Ala His Arg 
945                 950                 955                 960 


Asp Phe Gly Pro Ala Ser Gln His Phe Leu Ser Thr Ser Val Gln Gly 
                965                 970                 975     


Pro Trp Glu Arg Ala Ile Ser Pro Asn Lys Val Pro Tyr Tyr Ile Asn 
            980                 985                 990         


His Glu Thr Gln Thr Thr Cys Trp  Asp His Pro Lys Met  Thr Glu Leu 
        995                 1000                 1005             


Tyr Gln  Ser Leu Ala Asp Leu  Asn Asn Val Arg Phe  Ser Ala Tyr 
    1010                 1015                 1020             


Arg Thr  Ala Met Lys Leu Arg  Arg Leu Gln Lys Ala  Leu Cys Leu 
    1025                 1030                 1035             


Asp Leu  Leu Ser Leu Ser Ala  Ala Cys Asp Ala Leu  Asp Gln His 
    1040                 1045                 1050             


Asn Leu  Lys Gln Asn Asp Gln  Pro Met Asp Ile Leu  Gln Ile Ile 
    1055                 1060                 1065             


Asn Cys  Leu Thr Thr Ile Tyr  Asp Arg Leu Glu Gln  Glu His Asn 
    1070                 1075                 1080             


Asn Leu  Val Asn Val Pro Leu  Cys Val Asp Met Cys  Leu Asn Trp 
    1085                 1090                 1095             


Leu Leu  Asn Val Tyr Asp Thr  Gly Arg Thr Gly Arg  Ile Arg Val 
    1100                 1105                 1110             


Leu Ser  Phe Lys Thr Gly Ile  Ile Ser Leu Cys Lys  Ala His Leu 
    1115                 1120                 1125             


Glu Asp  Lys Tyr Arg Tyr Leu  Phe Lys Gln Val Ala  Ser Ser Thr 
    1130                 1135                 1140             


Gly Phe  Cys Asp Gln Arg Arg  Leu Gly Leu Leu Leu  His Asp Ser 
    1145                 1150                 1155             


Ile Gln  Ile Pro Arg Gln Leu  Gly Glu Val Ala Ser  Phe Gly Gly 
    1160                 1165                 1170             


Ser Asn  Ile Glu Pro Ser Val  Arg Ser Cys Phe Gln  Phe Ala Asn 
    1175                 1180                 1185             


Asn Lys  Pro Glu Ile Glu Ala  Ala Leu Phe Leu Asp  Trp Met Arg 
    1190                 1195                 1200             


Leu Glu  Pro Gln Ser Met Val  Trp Leu Pro Val Leu  His Arg Val 
    1205                 1210                 1215             


Ala Ala  Ala Glu Thr Ala Lys  His Gln Ala Lys Cys  Asn Ile Cys 
    1220                 1225                 1230             


Lys Glu  Cys Pro Ile Ile Gly  Phe Arg Tyr Arg Ser  Leu Lys His 
    1235                 1240                 1245             


Phe Asn  Tyr Asp Ile Cys Gln  Ser Cys Phe Phe Ser  Gly Arg Val 
    1250                 1255                 1260             


Ala Lys  Gly His Lys Met His  Tyr Pro Met Val Glu  Tyr Cys Thr 
    1265                 1270                 1275             


Pro Thr  Thr Ser Gly Glu Asp  Val Arg Asp Phe Ala  Lys Val Leu 
    1280                 1285                 1290             


Lys Asn  Lys Phe Arg Thr Lys  Arg Tyr Phe Ala Lys  His Pro Arg 
    1295                 1300                 1305             


Met Gly  Tyr Leu Pro Val Gln  Thr Val Leu Glu Gly  Asp Asn Met 
    1310                 1315                 1320             


Glu Thr  
    1325 


<210>  3
<211>  606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3
gaattcggta ccccactacg ggtttaggct gcccatgtaa ggaggcaagg cctggggaca       60

cccgagatgc ctggttataa ttaacccaga catgtggctg cccccccccc ccccaacacc      120

tgctgcctct aaaaataacc ctgtccctgg tggatcccct gcatgcgaag atcttcgaac      180

aaggctgtgg gggactgagg gcaggctgta acaggcttgg gggccagggc ttatacgtgc      240

ctgggactcc caaagtatta ctgttccatg ttcccggcga agggccagct gtcccccgcc      300

agctagactc agcacttagt ttaggaacca gtgagcaagt cagcccttgg ggcagcccat      360

acaaggccat ggggctgggc aagctgcacg cctgggtccg gggtgggcac ggtgcccggg      420

caacgagctg aaagctcatc tgctctcagg ggcccctccc tggggacagc ccctcctggc      480

tagtcacacc ctgtaggctc ctctatataa cccaggggca caggggctgc cctcattcta      540

ccaccacctc cacagcacag acagacactc aggagccagc cagcgtcgag cggccgatcc      600

gccacc                                                                 606


<210>  4
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4
gaattcggta ccccactacg ggtctaggct gcccatgtaa ggaggcaagg cctggggaca       60

cccgagatgc ctggttataa ttaaccccaa cacctgctgc cccccccccc ccaacacctg      120

ctgcctctaa aaataaccct gtccctggtg gatcccctgc atgccccact acgggtttag      180

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      240

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      300

tggtggatcc cctgcatgcg aagatcttcg aacaaggctg tgggggactg agggcaggct      360

gtaacaggct tgggggccag ggcttatacg tgcctgggac tcccaaagta ttactgttcc      420

atgttcccgg cgaagggcca gctgtccccc gccagctaga ctcagcactt agtttaggaa      480

ccagtgagca agtcagccct tggggcagcc catacaaggc catggggctg ggcaagctgc      540

acgcctgggt ccggggtggg cacggtgccc gggcaacgag ctgaaagctc atctgctctc      600

aggggcccct ccctggggac agcccctcct ggctagtcac accctgtagg ctcctctata      660

taacccaggg gcacaggggc tgccctcatt ctaccaccac ctccacagca cagacagaca      720

ctcaggagcc agccagcgtc gagcggccga tccgccacc                             759


<210>  5
<211>  577
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5
ccactacggg tctaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccctgc atgcgaagat cttcgaacaa ggctgtgggg      180

gactgagggc aggctgtaac aggcttgggg gccagggctt atacgtgcct gggactccca      240

aagtattact gttccatgtt cccggcgaag ggccagctgt cccccgccag ctagactcag      300

cacttagttt aggaaccagt gagcaagtca gcccttgggg cagcccatac aaggccatgg      360

ggctgggcaa gctgcacgcc tgggtccggg gtgggcacgg tgcccgggca acgagctgaa      420

agctcatctg ctctcagggg cccctccctg gggacagccc ctcctggcta gtcacaccct      480

gtaggctcct ctatataacc caggggcaca ggggctgccc tcattctacc accacctcca      540

cagcacagac agacactcag gagccagcca gcgtcga                               577


<210>  6
<211>  67
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6
tgaggagctc gagaggccta ataaagagct cagatgcatc gatcagagtg tgttggtttt       60

ttgtgtg                                                                 67


<210>  7
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  8
<211>  145
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc      120

gagcgcgcag agagggagtg gccaa                                            145


<210>  9
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9
aggcctaata aagagctcag atgcatcgat cagagtgtgt tggttttttg tgtg             54


<210>  10
<211>  4955
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg taccccacta cgggtttagg      180

ctgcccatgt aaggaggcaa ggcctgggga cacccgagat gcctggttat aattaaccca      240

gacatgtggc tgcccccccc ccccccaaca cctgctgcct ctaaaaataa ccctgtccct      300

ggtggatccc ctgcatgcga agatcttcga acaaggctgt gggggactga gggcaggctg      360

taacaggctt gggggccagg gcttatacgt gcctgggact cccaaagtat tactgttcca      420

tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac      480

cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca      540

cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca      600

ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat      660

aacccagggg cacaggggct gccctcattc taccaccacc tccacagcac agacagacac      720

tcaggagcca gccagcgtcg agcggccgcc accatgcttt ggtgggagga agtggaggac      780

tgctacgagc gggaggacgt gcagaagaaa accttcacca agtgggtgaa cgcccagttc      840

agcaagttcg gcaagcagca catcgagaac ctgttcagcg acctgcagga cggcaggcgg      900

ctgctggacc tcctggaagg cctgaccggc cagaagctgc ccaaagagaa gggcagcacc      960

agggtgcacg ccctgaacaa cgtgaacaag gccctgaggg tgctgcagaa caacaacgtg     1020

gacctggtga acatcggcag caccgacatc gtggacggca accacaagct gaccctgggc     1080

ctgatctgga acatcatcct gcactggcag gtcaagaacg tgatgaagaa catcatggcc     1140

ggcctgcagc agaccaacag cgagaagatc ctgctgtcct gggtgcggca gagcaccagg     1200

aactaccccc aggtcaacgt gatcaacttc accacctctt ggagcgacgg cctggccctg     1260

aacgccctga tccacagcca caggcccgac ctgttcgact ggaacagcgt ggtgtgccag     1320

cagagcgcca cccagaggct ggaacacgcc ttcaacatcg ccagatacca gctgggcatc     1380

gagaagctgc tggatcccga ggacgtggac accacctacc ccgacaagaa aagcatcctc     1440

atgtacatca ccagcctgtt ccaggtgctg ccccagcagg tgtccatcga ggccatccag     1500

gaagtggaga tgctgcccag gccccccaag gtcaccaaag aggaacactt ccagctgcac     1560

caccagatgc actacagcca gcagatcacc gtgagcctgg cccagggcta cgagaggacc     1620

agcagcccca agcccaggtt caagagctac gcctacaccc aggccgccta cgtgaccacc     1680

tccgacccca ccaggtcccc cttccccagc cagcatctcg aagcccccga ggacaagagc     1740

ttcggcagca gcctgatgga aagcgaggtg aacctggaca gataccagac cgccctggaa     1800

gaagtgctgt cttggctgct gtccgccgag gacaccctgc aggcccaggg cgagatcagc     1860

aacgacgtgg aggtcgtgaa ggaccagttc cacacccacg agggctacat gatggacctg     1920

accgcccacc agggcagagt gggcaacatc ctgcagctgg gcagcaagct gatcggcacc     1980

ggcaagctgt ccgaggacga ggaaaccgag gtgcaggaac agatgaacct gctgaacagc     2040

agatgggagt gcctgagggt ggccagcatg gaaaagcaga gcaacctgca cagggtgctg     2100

atggatctgc agaaccagaa gctcaaagag ctgaacgact ggctgaccaa gaccgaggaa     2160

aggacccgga agatggaaga ggaacccctg ggccccgatc tcgaagatct gaagaggcag     2220

gtgcagcagc acaaggtgct gcaggaagat ctcgaacagg aacaggtccg ggtcaacagc     2280

ctgacccaca tggtcgtggt ggtggacgag agcagcggcg accacgccac cgctgccctg     2340

gaagagcagc tgaaggtgct gggcgacaga tgggccaaca tctgccggtg gaccgaggac     2400

agatgggtcc tcctgcagga ccagcccgac ctggcccctg gcctgacaac catcggcgcc     2460

agccccaccc agaccgtgac cctggtgacc cagcccgtgg tgaccaaaga gaccgccatc     2520

agcaagctgg aaatgcccag ctccctgatg ctggaagtgc ccacccacag gctcctccag     2580

cagttccccc tggacctgga aaagttcctg gcctggctga ccgaggccga gaccaccgcc     2640

aacgtgctgc aggacgccac caggaaagag aggctgctgg aagatagcaa gggcgtgaaa     2700

gagctgatga agcagtggca ggacctgcag ggggagattg aggcccacac cgacgtgtac     2760

cacaacctgg acgagaacag ccagaaaatc ctgagaagcc tggaaggcag cgacgacgcc     2820

gtgctgctgc agaggcggct ggacaacatg aacttcaagt ggagcgagct gaggaagaag     2880

agcctgaaca tcaggtccca tctggaagcc agcagcgacc agtggaagag gctgcacctg     2940

agcctgcagg aactgctcgt ctggctgcag ctgaaagacg acgagctgtc caggcaggcc     3000

cccatcggcg gcgacttccc cgccgtgcag aaacagaacg acgtgcacag ggccttcaag     3060

cgggagctga aaaccaaaga gcccgtgatc atgagcaccc tggaaaccgt gaggatcttc     3120

ctgaccgagc agcccctgga aggactggaa aagctgtacc aggaacccag agagctgccc     3180

cccgaggaac gggcccagaa cgtgaccagg ctgctgagaa agcaggccga ggaagtgaac     3240

accgagtggg agaagctgaa cctgcactcc gccgactggc agaggaagat cgacgagacc     3300

ctggaaaggc tccaggaact gcaggaagcc accgacgagc tggacctgaa gctgagacag     3360

gccgaggtga tcaagggcag ctggcagccc gtgggcgacc tgctgatcga ctccctgcag     3420

gatcacctgg aaaaagtgaa ggccctgcgg ggcgagatcg cccccctgaa agagaacgtc     3480

agccacgtca acgacctggc caggcagctg accaccctgg gcatccagct gtccccctac     3540

aacctgtcca ccctggaaga tctgaacaca aggtggaagc tgctgcaggt ggccgtggag     3600

gacagagtga ggcagctgca cgaggcccac agggacttcg gccctgcctc ccagcacttc     3660

ctgagcacca gcgtgcaggg cccctgggag agggccatct cccccaacaa ggtgccctac     3720

tacatcaacc acgagaccca gaccacctgc tgggaccacc ctaagatgac cgagctgtac     3780

cagtccctgg ccgacctgaa caatgtgcgg ttcagcgcct accggaccgc catgaagctg     3840

aggcggctgc agaaagccct gtgcctggat ctgctgtccc tgagcgccgc ctgcgacgcc     3900

ctggaccagc acaacctgaa gcagaacgac cagcccatgg atatcctgca gatcatcaac     3960

tgtctgacca ccatctacga caggctggaa caggaacaca acaacctggt caacgtgccc     4020

ctgtgcgtgg acatgtgcct gaactggctg ctgaacgtgt acgacaccgg caggaccggc     4080

cggatcaggg tgctgtcctt caagaccggc atcatcagcc tgtgcaaggc ccacctggaa     4140

gataagtacc gctacctgtt caagcaggtg gccagctcta ccggcttctg cgaccagcgg     4200

aggctgggcc tgctgctgca cgacagcatc cagatccccc ggcagctggg cgaggtggcc     4260

tccttcggcg gcagcaacat cgagcccagc gtgcggagct gcttccagtt cgccaacaac     4320

aagcccgaga tcgaggccgc cctgttcctg gactggatgc ggctggaacc ccagagcatg     4380

gtctggctgc ccgtgctgca cagagtggct gccgccgaga ccgccaagca ccaggccaag     4440

tgcaacatct gcaaagagtg ccccatcatc ggcttcaggt acagaagcct gaagcacttc     4500

aactacgaca tctgccagag ctgtttcttc agcggcaggg tggccaaggg ccacaaaatg     4560

cactacccca tggtggagta ctgcaccccc accacctccg gcgaggacgt gagggacttc     4620

gccaaggtgc tgaagaataa gttccggacc aagcggtact tcgccaaaca ccccaggatg     4680

ggctacctgc ccgtgcagac cgtgctggaa ggcgacaaca tggaaacctg ataacacgcg     4740

tcgactcgag aggcctaata aagagctcag atgcatcgat cagagtgtgt tggttttttg     4800

tgtgagatct aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4860

ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca     4920

gtgagcgagc gagcgcgcag agagggagtg gccaa                                4955


<210>  11
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  12
<211>  4955
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg taccccacta cgggtctagg      180

ctgcccatgt aaggaggcaa ggcctgggga cacccgagat gcctggttat aattaaccca      240

gacatgtggc tgcccccccc ccccccaaca cctgctgcct ctaaaaataa ccctgtccct      300

ggtggatccc ctgcatgcga agatcttcga acaaggctgt gggggactga gggcaggctg      360

taacaggctt gggggccagg gcttatacgt gcctgggact cccaaagtat tactgttcca      420

tgttcccggc gaagggccag ctgtcccccg ccagctagac tcagcactta gtttaggaac      480

cagtgagcaa gtcagccctt ggggcagccc atacaaggcc atggggctgg gcaagctgca      540

cgcctgggtc cggggtgggc acggtgcccg ggcaacgagc tgaaagctca tctgctctca      600

ggggcccctc cctggggaca gcccctcctg gctagtcaca ccctgtaggc tcctctatat      660

aacccagggg cacaggggct gccctcattc taccaccacc tccacagcac agacagacac      720

tcaggagcca gccagcgtcg agcggccgat ccgccaccat gctttggtgg gaggaagtgg      780

aggactgcta cgagagagag gacgtgcaga agaaaacctt caccaagtgg gtgaacgccc      840

agttcagcaa gttcggcaag cagcacatcg agaacctgtt cagcgacctg caggatggca      900

ggagactgct ggacctgctg gagggcctga ccggccagaa gctgcccaag gagaagggca      960

gcaccagagt gcacgccctg aacaacgtga acaaggccct gagagtgctg cagaacaaca     1020

acgtggacct ggtgaacatc ggcagcaccg acatcgtgga cggcaaccac aagctgaccc     1080

tgggcctgat ctggaacatc atcctgcact ggcaggtgaa gaacgtgatg aagaacatca     1140

tggccggcct gcagcagacc aacagcgaga agatcctgct gagctgggtg aggcagagca     1200

ccagaaacta cccccaggtg aacgtgatca acttcaccac ctcctggagc gacggcctgg     1260

ccctgaacgc cctgatccac agccacagac ccgacctgtt cgactggaac agcgtggtgt     1320

gtcagcagag cgccacccag agactggagc acgccttcaa catcgccaga taccagctgg     1380

gcatcgagaa gctgctggac cccgaggacg tggacaccac ctaccccgac aagaaaagca     1440

tcctcatgta cattaccagc ctgttccagg tgctgcccca gcaggtgtcc atcgaggcca     1500

tccaggaagt ggaaatgctg cccaggcccc ccaaagtgac caaggaggag cacttccagc     1560

tgcaccacca gatgcactac agccagcaga tcacagtgag cctggcccag ggctatgaga     1620

gaaccagcag ccccaagccc agattcaaga gctacgccta cacccaggcc gcctacgtga     1680

ccacctccga ccccaccaga agccccttcc ccagccagca cctggaggcc cccgaggaca     1740

agagcttcgg cagcagcctg atggagagcg aagtgaacct ggacagatac cagaccgccc     1800

tggaggaagt gctgtcctgg ctgctgagcg ccgaggacac cctgcaggcc cagggcgaga     1860

tcagcaacga cgtggaagtg gtgaaggacc agttccacac ccacgagggc tacatgatgg     1920

atctgaccgc ccaccagggc agagtgggca atatcctgca gctgggcagc aagctgatcg     1980

gcaccggcaa gctgagcgag gacgaggaga ccgaagtgca ggagcagatg aacctgctga     2040

acagcagatg ggagtgcctg agagtggcca gcatggagaa gcagagcaac ctgcacagag     2100

tgctgatgga cctgcagaac cagaagctga aggagctgaa cgactggctg accaagaccg     2160

aggagcggac cagaaagatg gaggaggagc ccctgggccc cgacctggag gacctgaaga     2220

gacaggtgca gcagcacaaa gtgctgcagg aggacctgga gcaggagcag gtgcgcgtga     2280

acagcctgac ccacatggtg gtggtcgtgg acgagagcag cggcgaccac gccacagccg     2340

ccctggaaga gcagctgaaa gtgctgggcg acagatgggc caatatttgt aggtggaccg     2400

aggacagatg ggtgctgctg caggaccagc ccgacctggc ccctggcctg accaccatcg     2460

gcgccagccc cacccagacc gtgaccctgg tgacccagcc cgtggtgaca aaggagaccg     2520

ccatcagcaa gctggagatg cccagctccc tgatgctgga agtgcccacc caccgcctgc     2580

tccagcagtt ccccctggac ctggagaagt tcctggcctg gctgaccgag gccgaaacca     2640

ccgccaatgt gctccaggac gccactagaa aggagaggct gctggaggac agcaagggcg     2700

tgaaagagct gatgaagcag tggcaggatc tgcagggcga aatcgaggcc cacaccgacg     2760

tgtaccacaa cctggacgag aacagccaga agattctgag gagcctggag ggcagcgacg     2820

acgccgtcct gctccagagg aggctggaca acatgaactt caagtggagc gagctgcgga     2880

agaagagcct gaacatccgg agccacctgg aagccagcag cgaccagtgg aagagactgc     2940

acctgagcct gcaggagctg ctggtgtggc tgcagctgaa ggacgacgag ctgagcagac     3000

aggcccccat cggcggcgac ttccccgccg tgcagaagca gaacgacgtg caccgggcct     3060

tcaagaggga gctgaaaacc aaggaacccg tgatcatgag caccctggag acagtgcgga     3120

tcttcctgac cgagcagccc ctggagggac tggagaagct gtaccaggag cccagagagc     3180

tgccccccga ggagagagcc cagaacgtga ccaggctgct gagaaagcag gccgaggaag     3240

tgaataccga gtgggagaag ctgaatctgc acagcgccga ctggcagaga aagatcgacg     3300

agaccctgga gagactccag gaactgcagg aagccaccga cgagctggac ctgaagctga     3360

gacaggccga agtgatcaag ggcagctggc agcctgtggg cgatctgctg atcgactccc     3420

tgcaggatca cctggagaaa gtgaaggccc tgcggggcga gatcgccccc ctgaaggaga     3480

atgtgagcca cgtgaacgac ctggccagac agctgaccac cctgggcatc cagctgagcc     3540

cctacaacct gagcacactg gaggatctga acacccggtg gaaactgctg caggtggccg     3600

tggaggatag agtgaggcag ctgcacgaag cccacagaga cttcggccct gcctcccagc     3660

acttcctgag caccagcgtg cagggcccct gggagagagc catctccccc aacaaagtgc     3720

cctactacat caaccacgag acccagacca cctgctggga ccaccctaag atgaccgagc     3780

tgtatcagag cctggccgac ctgaacaatg tgcggttcag cgcctacaga accgccatga     3840

agctgcggag actgcagaag gccctgtgcc tggatctgct gagcctgagc gccgcctgcg     3900

acgccctgga ccagcacaac ctgaagcaga atgaccagcc catggacatc ctgcagatca     3960

tcaactgcct gaccacaatc tacgaccggc tggaacagga gcacaacaac ctggtgaatg     4020

tgcccctgtg cgtggacatg tgcctgaatt ggctgctgaa cgtgtacgac accggcagga     4080

ccggcagaat ccgcgtgctg agcttcaaga ccggcatcat cagcctgtgc aaggcccacc     4140

tggaggataa gtaccgctac ctgttcaagc aggtggccag cagcaccggc ttctgcgatc     4200

agaggagact gggcctgctg ctgcacgata gcatccagat ccctaggcag ctgggcgaag     4260

tggccagctt tggcggcagc aacatcgagc cctctgtgag gagctgcttc cagttcgcca     4320

acaacaagcc cgagatcgag gccgccctgt tcctggactg gatgaggctg gagcctcaga     4380

gcatggtgtg gctgcctgtg ctgcacagag tggccgccgc cgagaccgcc aagcaccagg     4440

ccaagtgcaa tatctgcaag gagtgcccca tcatcggctt ccggtacagg agcctgaagc     4500

acttcaacta cgacatctgc cagagctgct ttttcagcgg cagagtggcc aagggccaca     4560

aaatgcacta ccccatggtg gagtactgca cccccaccac ctccggcgag gatgtgagag     4620

acttcgccaa agtgctgaag aataagttcc ggaccaagcg gtactttgcc aagcacccca     4680

ggatgggcta cctgcccgtg cagaccgtgc tggaaggcga caacatggag acctgatgag     4740

gagctcgaga ggcctaataa agagctcaga tgcatcgatc agagtgtgtt ggttttttgt     4800

gtgagatctg aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg     4860

ctcactgagg ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca     4920

gtgagcgagc gagcgcgcag agagggagtg gccaa                                4955


<210>  13
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210>  14
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gccagctggc       60

gtaatagcga agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctg             113


<210>  15
<211>  1035
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Met Pro Glu Gln Glu Arg Gln Ile Thr Ala Arg Glu Gly Ala Ser Arg 
1               5                   10                  15      


Lys Ile Leu Ser Lys Leu Ser Leu Pro Thr Arg Ala Trp Glu Pro Ala 
            20                  25                  30          


Met Lys Lys Ser Phe Ala Phe Asp Asn Val Gly Tyr Glu Gly Gly Leu 
        35                  40                  45              


Asp Gly Leu Gly Pro Ser Ser Gln Pro Gln Lys Cys Phe Leu Gln Ile 
    50                  55                  60                  


Lys Gly Met Thr Cys Ala Ser Cys Val Ser Asn Ile Glu Arg Asn Leu 
65                  70                  75                  80  


Gln Lys Glu Ala Gly Val Leu Ser Val Leu Val Ala Leu Met Ala Gly 
                85                  90                  95      


Lys Ala Glu Ile Lys Tyr Asp Pro Glu Val Ile Gln Pro Leu Glu Ile 
            100                 105                 110         


Ala Gln Phe Ile Gln Asp Leu Gly Phe Glu Ala Ala Val Met Glu Asp 
        115                 120                 125             


Tyr Ala Gly Ser Asp Gly Asn Ile Glu Leu Thr Ile Thr Gly Met Thr 
    130                 135                 140                 


Cys Ala Ser Cys Val His Asn Ile Glu Ser Lys Leu Thr Arg Thr Asn 
145                 150                 155                 160 


Gly Ile Thr Tyr Ala Ser Val Ala Leu Ala Thr Ser Lys Ala Leu Val 
                165                 170                 175     


Lys Phe Asp Pro Glu Ile Ile Gly Pro Arg Asp Ile Ile Lys Ile Ile 
            180                 185                 190         


Glu Glu Ile Gly Phe His Ala Ser Leu Ala Gln Arg Asn Pro Asn Ala 
        195                 200                 205             


His His Leu Asp His Lys Met Glu Ile Lys Gln Trp Lys Lys Ser Phe 
    210                 215                 220                 


Leu Cys Ser Leu Val Phe Gly Ile Pro Val Met Ala Leu Met Ile Tyr 
225                 230                 235                 240 


Met Leu Ile Pro Ser Asn Glu Pro His Gln Ser Met Val Leu Asp His 
                245                 250                 255     


Asn Ile Ile Pro Gly Leu Ser Ile Leu Asn Leu Ile Phe Phe Ile Leu 
            260                 265                 270         


Cys Thr Phe Val Gln Leu Leu Gly Gly Trp Tyr Phe Tyr Val Gln Ala 
        275                 280                 285             


Tyr Lys Ser Leu Arg His Arg Ser Ala Asn Met Asp Val Leu Ile Val 
    290                 295                 300                 


Leu Ala Thr Ser Ile Ala Tyr Val Tyr Ser Leu Val Ile Leu Val Val 
305                 310                 315                 320 


Ala Val Ala Glu Lys Ala Glu Arg Ser Pro Val Thr Phe Phe Asp Thr 
                325                 330                 335     


Pro Pro Met Leu Phe Val Phe Ile Ala Leu Gly Arg Trp Leu Glu His 
            340                 345                 350         


Leu Ala Lys Ser Lys Thr Ser Glu Ala Leu Ala Lys Leu Met Ser Leu 
        355                 360                 365             


Gln Ala Thr Glu Ala Thr Val Val Thr Leu Gly Glu Asp Asn Leu Ile 
    370                 375                 380                 


Ile Arg Glu Glu Gln Val Pro Met Glu Leu Val Gln Arg Gly Asp Ile 
385                 390                 395                 400 


Val Lys Val Val Pro Gly Gly Lys Phe Pro Val Asp Gly Lys Val Leu 
                405                 410                 415     


Glu Gly Asn Thr Met Ala Asp Glu Ser Leu Ile Thr Gly Glu Ala Met 
            420                 425                 430         


Pro Val Thr Lys Lys Pro Gly Ser Thr Val Ile Ala Gly Ser Ile Asn 
        435                 440                 445             


Ala His Gly Ser Val Leu Ile Lys Ala Thr His Val Gly Asn Asp Thr 
    450                 455                 460                 


Thr Leu Ala Gln Ile Val Lys Leu Val Glu Glu Ala Gln Met Ser Lys 
465                 470                 475                 480 


Ala Pro Ile Gln Gln Leu Ala Asp Arg Phe Ser Gly Tyr Phe Val Pro 
                485                 490                 495     


Phe Ile Ile Ile Met Ser Thr Leu Thr Leu Val Val Trp Ile Val Ile 
            500                 505                 510         


Gly Phe Ile Asp Phe Gly Val Val Gln Arg Tyr Phe Pro Asn Pro Asn 
        515                 520                 525             


Lys His Ile Ser Gln Thr Glu Val Ile Ile Arg Phe Ala Phe Gln Thr 
    530                 535                 540                 


Ser Ile Thr Val Leu Cys Ile Ala Cys Pro Cys Ser Leu Gly Leu Ala 
545                 550                 555                 560 


Thr Pro Thr Ala Val Met Val Gly Thr Gly Val Ala Ala Gln Asn Gly 
                565                 570                 575     


Ile Leu Ile Lys Gly Gly Lys Pro Leu Glu Met Ala His Lys Ile Lys 
            580                 585                 590         


Thr Val Met Phe Asp Lys Thr Gly Thr Ile Thr His Gly Val Pro Arg 
        595                 600                 605             


Val Met Arg Val Leu Leu Leu Gly Asp Val Ala Thr Leu Pro Leu Arg 
    610                 615                 620                 


Lys Val Leu Ala Val Val Gly Thr Ala Glu Ala Ser Ser Glu His Pro 
625                 630                 635                 640 


Leu Gly Val Ala Val Thr Lys Tyr Cys Lys Glu Glu Leu Gly Thr Glu 
                645                 650                 655     


Thr Leu Gly Tyr Cys Thr Asp Phe Gln Ala Val Pro Gly Cys Gly Ile 
            660                 665                 670         


Gly Cys Lys Val Ser Asn Val Glu Gly Ile Leu Ala His Ser Glu Arg 
        675                 680                 685             


Pro Leu Ser Ala Pro Ala Ser His Leu Asn Glu Ala Gly Ser Leu Pro 
    690                 695                 700                 


Ala Glu Lys Asp Ala Val Pro Gln Thr Phe Ser Val Leu Ile Gly Asn 
705                 710                 715                 720 


Arg Glu Trp Leu Arg Arg Asn Gly Leu Thr Ile Ser Ser Asp Val Ser 
                725                 730                 735     


Asp Ala Met Thr Asp His Glu Met Lys Gly Gln Thr Ala Ile Leu Val 
            740                 745                 750         


Ala Ile Asp Gly Val Leu Cys Gly Met Ile Ala Ile Ala Asp Ala Val 
        755                 760                 765             


Lys Gln Glu Ala Ala Leu Ala Val His Thr Leu Gln Ser Met Gly Val 
    770                 775                 780                 


Asp Val Val Leu Ile Thr Gly Asp Asn Arg Lys Thr Ala Arg Ala Ile 
785                 790                 795                 800 


Ala Thr Gln Val Gly Ile Asn Lys Val Phe Ala Glu Val Leu Pro Ser 
                805                 810                 815     


His Lys Val Ala Lys Val Gln Glu Leu Gln Asn Lys Gly Lys Lys Val 
            820                 825                 830         


Ala Met Val Gly Asp Gly Val Asn Asp Ser Pro Ala Leu Ala Gln Ala 
        835                 840                 845             


Asp Met Gly Val Ala Ile Gly Thr Gly Thr Asp Val Ala Ile Glu Ala 
    850                 855                 860                 


Ala Asp Val Val Leu Ile Arg Asn Asp Leu Leu Asp Val Val Ala Ser 
865                 870                 875                 880 


Ile His Leu Ser Lys Arg Thr Val Arg Arg Ile Arg Ile Asn Leu Val 
                885                 890                 895     


Leu Ala Leu Ile Tyr Asn Leu Val Gly Ile Pro Ile Ala Ala Gly Val 
            900                 905                 910         


Phe Met Pro Ile Gly Ile Val Leu Gln Pro Trp Met Gly Ser Ala Ala 
        915                 920                 925             


Met Ala Ala Ser Ser Val Ser Val Val Leu Ser Ser Leu Gln Leu Lys 
    930                 935                 940                 


Cys Tyr Lys Lys Pro Asp Leu Glu Arg Tyr Glu Ala Gln Ala His Gly 
945                 950                 955                 960 


His Met Lys Pro Leu Thr Ala Ser Gln Val Ser Val His Ile Gly Met 
                965                 970                 975     


Asp Asp Arg Trp Arg Asp Ser Pro Arg Ala Thr Pro Trp Asp Gln Val 
            980                 985                 990         


Ser Tyr Val Ser Gln Val Ser Leu  Ser Ser Leu Thr Ser  Asp Lys Pro 
        995                 1000                 1005             


Ser Arg  His Ser Ala Ala Ala  Asp Asp Asp Gly Asp  Lys Trp Ser 
    1010                 1015                 1020             


Leu Leu  Leu Asn Gly Arg Asp  Glu Glu Gln Tyr Ile  
    1025                 1030                 1035 


<210>  16
<211>  305
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
cgccaccccc tccaccttgg acacaggacg ctgtggtttc tgagccaggt acaatgactc       60

ctttcggtaa gtgcagtgga agctgtacac tgcccaggca aagcgtccgg gcagcgtagg      120

cgggcgactc agatcccagc cagtggactt agcccctgtt tgctcctccg ataactgggg      180

tgaccttggt taatattcac cagcagcctc ccccgttgcc cctctggatc cactgcttaa      240

atacggacga ggacagggcc ctgtctcctc agcttcaggc accaccactg acctgggaca      300

gtgaa                                                                  305


<210>  17
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
aataaagacc tcttattttc attcatcagg tgtggttggt ttttttgtgt gggggc           56


<210>  18
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


