                         SEQUENCE LISTING

<110>  INSERM
 
<120>  METHODS FOR DIAGNOSIS AND TREATING POLYCYSTIC OVARY SYNDROME 
       (PCOS)

<130>  BIO20210 GIACOBINI/AF

<160>  5     

<170>  PatentIn version 3.3

<210>  1
<211>  2136
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Arg Ser Arg His Ala Arg Pro Ser Arg Leu Val Arg Lys Glu 
1               5                   10                  15      


Asp Val Asn Lys Lys Lys Lys Asn Ser Gln Leu Arg Lys Thr Thr Lys 
            20                  25                  30          


Gly Ala Asn Lys Asn Val Ala Ser Val Lys Thr Leu Ser Pro Gly Lys 
        35                  40                  45              


Leu Lys Gln Leu Ile Gln Glu Arg Asp Val Lys Lys Lys Thr Glu Pro 
    50                  55                  60                  


Lys Pro Pro Val Pro Val Arg Ser Leu Leu Thr Arg Ala Gly Ala Ala 
65                  70                  75                  80  


Arg Met Asn Leu Asp Arg Thr Glu Val Leu Phe Gln Asn Pro Glu Ser 
                85                  90                  95      


Leu Thr Cys Asn Gly Phe Thr Met Ala Leu Arg Ser Thr Ser Leu Ser 
            100                 105                 110         


Arg Arg Leu Ser Gln Pro Pro Leu Val Val Ala Lys Ser Lys Lys Val 
        115                 120                 125             


Pro Leu Ser Lys Gly Leu Glu Lys Gln His Asp Cys Asp Tyr Lys Ile 
    130                 135                 140                 


Leu Pro Ala Leu Gly Val Lys His Ser Glu Asn Asp Ser Val Pro Met 
145                 150                 155                 160 


Gln Asp Thr Gln Val Leu Pro Asp Ile Glu Thr Leu Ile Gly Val Gln 
                165                 170                 175     


Asn Pro Ser Leu Leu Lys Gly Lys Ser Gln Glu Thr Thr Gln Phe Trp 
            180                 185                 190         


Ser Gln Arg Val Glu Asp Ser Lys Ile Asn Ile Pro Thr His Ser Gly 
        195                 200                 205             


Pro Ala Ala Glu Ile Leu Pro Gly Pro Leu Glu Gly Thr Arg Cys Gly 
    210                 215                 220                 


Glu Gly Leu Phe Ser Glu Glu Thr Leu Asn Asp Thr Ser Gly Ser Pro 
225                 230                 235                 240 


Lys Met Phe Ala Gln Asp Thr Val Cys Ala Pro Phe Pro Gln Arg Ala 
                245                 250                 255     


Thr Pro Lys Val Thr Ser Gln Gly Asn Pro Ser Ile Gln Leu Glu Glu 
            260                 265                 270         


Leu Gly Ser Arg Val Glu Ser Leu Lys Leu Ser Asp Ser Tyr Leu Asp 
        275                 280                 285             


Pro Ile Lys Ser Glu His Asp Cys Tyr Pro Thr Ser Ser Leu Asn Lys 
    290                 295                 300                 


Val Ile Pro Asp Leu Asn Leu Arg Asn Cys Leu Ala Leu Gly Gly Ser 
305                 310                 315                 320 


Thr Ser Pro Thr Ser Val Ile Lys Phe Leu Leu Ala Gly Ser Lys Gln 
                325                 330                 335     


Ala Thr Leu Gly Ala Lys Pro Asp His Gln Glu Ala Phe Glu Ala Thr 
            340                 345                 350         


Ala Asn Gln Gln Glu Val Ser Asp Thr Thr Ser Phe Leu Gly Gln Ala 
        355                 360                 365             


Phe Gly Ala Ile Pro His Gln Trp Glu Leu Pro Gly Ala Asp Pro Val 
    370                 375                 380                 


His Gly Glu Ala Leu Gly Glu Thr Pro Asp Leu Pro Glu Ile Pro Gly 
385                 390                 395                 400 


Ala Ile Pro Val Gln Gly Glu Val Phe Gly Thr Ile Leu Asp Gln Gln 
                405                 410                 415     


Glu Thr Leu Gly Met Ser Gly Ser Val Val Pro Asp Leu Pro Val Phe 
            420                 425                 430         


Leu Pro Val Pro Pro Asn Pro Ile Ala Thr Phe Asn Ala Pro Ser Lys 
        435                 440                 445             


Trp Pro Glu Pro Gln Ser Thr Val Ser Tyr Gly Leu Ala Val Gln Gly 
    450                 455                 460                 


Ala Ile Gln Ile Leu Pro Leu Gly Ser Gly His Thr Pro Gln Ser Ser 
465                 470                 475                 480 


Ser Asn Ser Glu Lys Asn Ser Leu Pro Pro Val Met Ala Ile Ser Asn 
                485                 490                 495     


Val Glu Asn Glu Lys Gln Val His Ile Ser Phe Leu Pro Ala Asn Thr 
            500                 505                 510         


Gln Gly Phe Pro Leu Ala Pro Glu Arg Gly Leu Phe His Ala Ser Leu 
        515                 520                 525             


Gly Ile Ala Gln Leu Ser Gln Ala Gly Pro Ser Lys Ser Asp Arg Gly 
    530                 535                 540                 


Ser Ser Gln Val Ser Val Thr Ser Thr Val His Val Val Asn Thr Thr 
545                 550                 555                 560 


Val Val Thr Met Pro Val Pro Met Val Ser Thr Ser Ser Ser Ser Tyr 
                565                 570                 575     


Thr Thr Leu Leu Pro Thr Leu Glu Lys Lys Lys Arg Lys Arg Cys Gly 
            580                 585                 590         


Val Cys Glu Pro Cys Gln Gln Lys Thr Asn Cys Gly Glu Cys Thr Tyr 
        595                 600                 605             


Cys Lys Asn Arg Lys Asn Ser His Gln Ile Cys Lys Lys Arg Lys Cys 
    610                 615                 620                 


Glu Glu Leu Lys Lys Lys Pro Ser Val Val Val Pro Leu Glu Val Ile 
625                 630                 635                 640 


Lys Glu Asn Lys Arg Pro Gln Arg Glu Lys Lys Pro Lys Val Leu Lys 
                645                 650                 655     


Ala Asp Phe Asp Asn Lys Pro Val Asn Gly Pro Lys Ser Glu Ser Met 
            660                 665                 670         


Asp Tyr Ser Arg Cys Gly His Gly Glu Glu Gln Lys Leu Glu Leu Asn 
        675                 680                 685             


Pro His Thr Val Glu Asn Val Thr Lys Asn Glu Asp Ser Met Thr Gly 
    690                 695                 700                 


Ile Glu Val Glu Lys Trp Thr Gln Asn Lys Lys Ser Gln Leu Thr Asp 
705                 710                 715                 720 


His Val Lys Gly Asp Phe Ser Ala Asn Val Pro Glu Ala Glu Lys Ser 
                725                 730                 735     


Lys Asn Ser Glu Val Asp Lys Lys Arg Thr Lys Ser Pro Lys Leu Phe 
            740                 745                 750         


Val Gln Thr Val Arg Asn Gly Ile Lys His Val His Cys Leu Pro Ala 
        755                 760                 765             


Glu Thr Asn Val Ser Phe Lys Lys Phe Asn Ile Glu Glu Phe Gly Lys 
    770                 775                 780                 


Thr Leu Glu Asn Asn Ser Tyr Lys Phe Leu Lys Asp Thr Ala Asn His 
785                 790                 795                 800 


Lys Asn Ala Met Ser Ser Val Ala Thr Asp Met Ser Cys Asp His Leu 
                805                 810                 815     


Lys Gly Arg Ser Asn Val Leu Val Phe Gln Gln Pro Gly Phe Asn Cys 
            820                 825                 830         


Ser Ser Ile Pro His Ser Ser His Ser Ile Ile Asn His His Ala Ser 
        835                 840                 845             


Ile His Asn Glu Gly Asp Gln Pro Lys Thr Pro Glu Asn Ile Pro Ser 
    850                 855                 860                 


Lys Glu Pro Lys Asp Gly Ser Pro Val Gln Pro Ser Leu Leu Ser Leu 
865                 870                 875                 880 


Met Lys Asp Arg Arg Leu Thr Leu Glu Gln Val Val Ala Ile Glu Ala 
                885                 890                 895     


Leu Thr Gln Leu Ser Glu Ala Pro Ser Glu Asn Ser Ser Pro Ser Lys 
            900                 905                 910         


Ser Glu Lys Asp Glu Glu Ser Glu Gln Arg Thr Ala Ser Leu Leu Asn 
        915                 920                 925             


Ser Cys Lys Ala Ile Leu Tyr Thr Val Arg Lys Asp Leu Gln Asp Pro 
    930                 935                 940                 


Asn Leu Gln Gly Glu Pro Pro Lys Leu Asn His Cys Pro Ser Leu Glu 
945                 950                 955                 960 


Lys Gln Ser Ser Cys Asn Thr Val Val Phe Asn Gly Gln Thr Thr Thr 
                965                 970                 975     


Leu Ser Asn Ser His Ile Asn Ser Ala Thr Asn Gln Ala Ser Thr Lys 
            980                 985                 990         


Ser His Glu Tyr Ser Lys Val Thr  Asn Ser Leu Ser Leu  Phe Ile Pro 
        995                 1000                 1005             


Lys Ser  Asn Ser Ser Lys Ile  Asp Thr Asn Lys Ser  Ile Ala Gln 
    1010                 1015                 1020             


Gly Ile  Ile Thr Leu Asp Asn  Cys Ser Asn Asp Leu  His Gln Leu 
    1025                 1030                 1035             


Pro Pro  Arg Asn Asn Glu Val  Glu Tyr Cys Asn Gln  Leu Leu Asp 
    1040                 1045                 1050             


Ser Ser  Lys Lys Leu Asp Ser  Asp Asp Leu Ser Cys  Gln Asp Ala 
    1055                 1060                 1065             


Thr His  Thr Gln Ile Glu Glu  Asp Val Ala Thr Gln  Leu Thr Gln 
    1070                 1075                 1080             


Leu Ala  Ser Ile Ile Lys Ile  Asn Tyr Ile Lys Pro  Glu Asp Lys 
    1085                 1090                 1095             


Lys Val  Glu Ser Thr Pro Thr  Ser Leu Val Thr Cys  Asn Val Gln 
    1100                 1105                 1110             


Gln Lys  Tyr Asn Gln Glu Lys  Gly Thr Ile Gln Gln  Lys Pro Pro 
    1115                 1120                 1125             


Ser Ser  Val His Asn Asn His  Gly Ser Ser Leu Thr  Lys Gln Lys 
    1130                 1135                 1140             


Asn Pro  Thr Gln Lys Lys Thr  Lys Ser Thr Pro Ser  Arg Asp Arg 
    1145                 1150                 1155             


Arg Lys  Lys Lys Pro Thr Val  Val Ser Tyr Gln Glu  Asn Asp Arg 
    1160                 1165                 1170             


Gln Lys  Trp Glu Lys Leu Ser  Tyr Met Tyr Gly Thr  Ile Cys Asp 
    1175                 1180                 1185             


Ile Trp  Ile Ala Ser Lys Phe  Gln Asn Phe Gly Gln  Phe Cys Pro 
    1190                 1195                 1200             


His Asp  Phe Pro Thr Val Phe  Gly Lys Ile Ser Ser  Ser Thr Lys 
    1205                 1210                 1215             


Ile Trp  Lys Pro Leu Ala Gln  Thr Arg Ser Ile Met  Gln Pro Lys 
    1220                 1225                 1230             


Thr Val  Phe Pro Pro Leu Thr  Gln Ile Lys Leu Gln  Arg Tyr Pro 
    1235                 1240                 1245             


Glu Ser  Ala Glu Glu Lys Val  Lys Val Glu Pro Leu  Asp Ser Leu 
    1250                 1255                 1260             


Ser Leu  Phe His Leu Lys Thr  Glu Ser Asn Gly Lys  Ala Phe Thr 
    1265                 1270                 1275             


Asp Lys  Ala Tyr Asn Ser Gln  Val Gln Leu Thr Val  Asn Ala Asn 
    1280                 1285                 1290             


Gln Lys  Ala His Pro Leu Thr  Gln Pro Ser Ser Pro  Pro Asn Gln 
    1295                 1300                 1305             


Cys Ala  Asn Val Met Ala Gly  Asp Asp Gln Ile Arg  Phe Gln Gln 
    1310                 1315                 1320             


Val Val  Lys Glu Gln Leu Met  His Gln Arg Leu Pro  Thr Leu Pro 
    1325                 1330                 1335             


Gly Ile  Ser His Glu Thr Pro  Leu Pro Glu Ser Ala  Leu Thr Leu 
    1340                 1345                 1350             


Arg Asn  Val Asn Val Val Cys  Ser Gly Gly Ile Thr  Val Val Ser 
    1355                 1360                 1365             


Thr Lys  Ser Glu Glu Glu Val  Cys Ser Ser Ser Phe  Gly Thr Ser 
    1370                 1375                 1380             


Glu Phe  Ser Thr Val Asp Ser  Ala Gln Lys Asn Phe  Asn Asp Tyr 
    1385                 1390                 1395             


Ala Met  Asn Phe Phe Thr Asn  Pro Thr Lys Asn Leu  Val Ser Ile 
    1400                 1405                 1410             


Thr Lys  Asp Ser Glu Leu Pro  Thr Cys Ser Cys Leu  Asp Arg Val 
    1415                 1420                 1425             


Ile Gln  Lys Asp Lys Gly Pro  Tyr Tyr Thr His Leu  Gly Ala Gly 
    1430                 1435                 1440             


Pro Ser  Val Ala Ala Val Arg  Glu Ile Met Glu Asn  Arg Tyr Gly 
    1445                 1450                 1455             


Gln Lys  Gly Asn Ala Ile Arg  Ile Glu Ile Val Val  Tyr Thr Gly 
    1460                 1465                 1470             


Lys Glu  Gly Lys Ser Ser His  Gly Cys Pro Ile Ala  Lys Trp Val 
    1475                 1480                 1485             


Leu Arg  Arg Ser Ser Asp Glu  Glu Lys Val Leu Cys  Leu Val Arg 
    1490                 1495                 1500             


Gln Arg  Thr Gly His His Cys  Pro Thr Ala Val Met  Val Val Leu 
    1505                 1510                 1515             


Ile Met  Val Trp Asp Gly Ile  Pro Leu Pro Met Ala  Asp Arg Leu 
    1520                 1525                 1530             


Tyr Thr  Glu Leu Thr Glu Asn  Leu Lys Ser Tyr Asn  Gly His Pro 
    1535                 1540                 1545             


Thr Asp  Arg Arg Cys Thr Leu  Asn Glu Asn Arg Thr  Cys Thr Cys 
    1550                 1555                 1560             


Gln Gly  Ile Asp Pro Glu Thr  Cys Gly Ala Ser Phe  Ser Phe Gly 
    1565                 1570                 1575             


Cys Ser  Trp Ser Met Tyr Phe  Asn Gly Cys Lys Phe  Gly Arg Ser 
    1580                 1585                 1590             


Pro Ser  Pro Arg Arg Phe Arg  Ile Asp Pro Ser Ser  Pro Leu His 
    1595                 1600                 1605             


Glu Lys  Asn Leu Glu Asp Asn  Leu Gln Ser Leu Ala  Thr Arg Leu 
    1610                 1615                 1620             


Ala Pro  Ile Tyr Lys Gln Tyr  Ala Pro Val Ala Tyr  Gln Asn Gln 
    1625                 1630                 1635             


Val Glu  Tyr Glu Asn Val Ala  Arg Glu Cys Arg Leu  Gly Ser Lys 
    1640                 1645                 1650             


Glu Gly  Arg Pro Phe Ser Gly  Val Thr Ala Cys Leu  Asp Phe Cys 
    1655                 1660                 1665             


Ala His  Pro His Arg Asp Ile  His Asn Met Asn Asn  Gly Ser Thr 
    1670                 1675                 1680             


Val Val  Cys Thr Leu Thr Arg  Glu Asp Asn Arg Ser  Leu Gly Val 
    1685                 1690                 1695             


Ile Pro  Gln Asp Glu Gln Leu  His Val Leu Pro Leu  Tyr Lys Leu 
    1700                 1705                 1710             


Ser Asp  Thr Asp Glu Phe Gly  Ser Lys Glu Gly Met  Glu Ala Lys 
    1715                 1720                 1725             


Ile Lys  Ser Gly Ala Ile Glu  Val Leu Ala Pro Arg  Arg Lys Lys 
    1730                 1735                 1740             


Arg Thr  Cys Phe Thr Gln Pro  Val Pro Arg Ser Gly  Lys Lys Arg 
    1745                 1750                 1755             


Ala Ala  Met Met Thr Glu Val  Leu Ala His Lys Ile  Arg Ala Val 
    1760                 1765                 1770             


Glu Lys  Lys Pro Ile Pro Arg  Ile Lys Arg Lys Asn  Asn Ser Thr 
    1775                 1780                 1785             


Thr Thr  Asn Asn Ser Lys Pro  Ser Ser Leu Pro Thr  Leu Gly Ser 
    1790                 1795                 1800             


Asn Thr  Glu Thr Val Gln Pro  Glu Val Lys Ser Glu  Thr Glu Pro 
    1805                 1810                 1815             


His Phe  Ile Leu Lys Ser Ser  Asp Asn Thr Lys Thr  Tyr Ser Leu 
    1820                 1825                 1830             


Met Pro  Ser Ala Pro His Pro  Val Lys Glu Ala Ser  Pro Gly Phe 
    1835                 1840                 1845             


Ser Trp  Ser Pro Lys Thr Ala  Ser Ala Thr Pro Ala  Pro Leu Lys 
    1850                 1855                 1860             


Asn Asp  Ala Thr Ala Ser Cys  Gly Phe Ser Glu Arg  Ser Ser Thr 
    1865                 1870                 1875             


Pro His  Cys Thr Met Pro Ser  Gly Arg Leu Ser Gly  Ala Asn Ala 
    1880                 1885                 1890             


Ala Ala  Ala Asp Gly Pro Gly  Ile Ser Gln Leu Gly  Glu Val Ala 
    1895                 1900                 1905             


Pro Leu  Pro Thr Leu Ser Ala  Pro Val Met Glu Pro  Leu Ile Asn 
    1910                 1915                 1920             


Ser Glu  Pro Ser Thr Gly Val  Thr Glu Pro Leu Thr  Pro His Gln 
    1925                 1930                 1935             


Pro Asn  His Gln Pro Ser Phe  Leu Thr Ser Pro Gln  Asp Leu Ala 
    1940                 1945                 1950             


Ser Ser  Pro Met Glu Glu Asp  Glu Gln His Ser Glu  Ala Asp Glu 
    1955                 1960                 1965             


Pro Pro  Ser Asp Glu Pro Leu  Ser Asp Asp Pro Leu  Ser Pro Ala 
    1970                 1975                 1980             


Glu Glu  Lys Leu Pro His Ile  Asp Glu Tyr Trp Ser  Asp Ser Glu 
    1985                 1990                 1995             


His Ile  Phe Leu Asp Ala Asn  Ile Gly Gly Val Ala  Ile Ala Pro 
    2000                 2005                 2010             


Ala His  Gly Ser Val Leu Ile  Glu Cys Ala Arg Arg  Glu Leu His 
    2015                 2020                 2025             


Ala Thr  Thr Pro Val Glu His  Pro Asn Arg Asn His  Pro Thr Arg 
    2030                 2035                 2040             


Leu Ser  Leu Val Phe Tyr Gln  His Lys Asn Leu Asn  Lys Pro Gln 
    2045                 2050                 2055             


His Gly  Phe Glu Leu Asn Lys  Ile Lys Phe Glu Ala  Lys Glu Ala 
    2060                 2065                 2070             


Lys Asn  Lys Lys Met Lys Ala  Ser Glu Gln Lys Asp  Gln Ala Ala 
    2075                 2080                 2085             


Asn Glu  Gly Pro Glu Gln Ser  Ser Glu Val Asn Glu  Leu Asn Gln 
    2090                 2095                 2100             


Ile Pro  Ser His Lys Ala Leu  Thr Leu Thr His Asp  Asn Val Val 
    2105                 2110                 2115             


Thr Val  Ser Pro Tyr Ala Leu  Thr His Val Ala Gly  Pro Tyr Asn 
    2120                 2125                 2130             


His Trp  Val 
    2135     


<210>  2
<211>  9612
<212>  DNA
<213>  Homo sapiens

<400>  2
actccctgag gtctgtcctg gggagacact gctgctccgg ggggctgacc tggcggggag     60

tggccgcgca gtctgctccg gcgccgcttt gtgcgcgcag ccgctggccc ctctactccc    120

gggtctgccc cccgggacac ccctctgcct cgcccaagtc atgcagccct acctgcctct    180

ccactgtgga cctttgggaa ccgactcctc acctcggggg ctcgggcctt gactgtgctg    240

ggagccggta ggcgtcctcc gcgacccgcc cgcgcccctc gcgcccgccg gggccccggg    300

ctccaaagtt gtggggaccg gcgcgagttg gaaagtttgc ccgagggctg gtgcaggctt    360

ggagctgggg gccgtgcgct gccctgggaa tgtgacccgg ccagcgacca aaaccttgtg    420

tgactgagct gaagagcagt gcatccagat tctcctcaga agtgagactt tccaaaggac    480

caatgactct gtttcctgcg ccctttcatt ttttcctact ctgtagctat gtctcgatcc    540

cgccatgcaa ggccttccag attagtcagg aaggaagatg taaacaaaaa aaagaaaaac    600

agccaactac gaaagacaac caagggagcc aacaaaaatg tggcatcagt caagacttta    660

agccctggaa aattaaagca attaattcaa gaaagagatg ttaagaaaaa aacagaacct    720

aaaccacccg tgccagtcag aagccttctg acaagagctg gagcagcacg catgaatttg    780

gataggactg aggttctttt tcagaaccca gagtccttaa cctgcaatgg gtttacaatg    840

gcgctacgaa gcacctctct tagcaggcga ctctcccaac ccccactggt cgtagccaaa    900

tccaaaaagg ttccactttc taagggttta gaaaagcaac atgattgtga ttataagata    960

ctccctgctt tgggagtaaa gcactcagaa aatgattcgg ttccaatgca agacacccaa   1020

gtccttcctg atatagagac tctaattggt gtacaaaatc cctctttact taaaggtaag   1080

agccaagaga caactcagtt ttggtcccaa agagttgagg attccaagat caatatccct   1140

acccacagtg gccctgcagc tgagatcctt cctgggccac tggaagggac acgctgtggt   1200

gaaggactat tctctgaaga gacattgaat gataccagtg gttccccaaa aatgtttgct   1260

caggacacag tgtgtgctcc ttttccccaa agagcaaccc ccaaagttac ctctcaagga   1320

aaccccagca ttcagttaga agagttgggt tcacgagtag aatctcttaa gttatctgat   1380

tcttacctgg atcccattaa aagtgaacat gattgctacc ccacctccag tcttaataag   1440

gttatacctg acttgaacct tagaaactgc ttggctcttg gtgggtctac gtctcctacc   1500

tctgtaataa aattcctctt ggcaggctca aaacaagcga cccttggtgc taaaccagat   1560

catcaagagg ccttcgaagc tactgcaaat caacaggaag tttctgatac cacctctttc   1620

ctaggacagg cctttggtgc tatcccacat caatgggaac ttcctggtgc tgacccagtt   1680

catggtgagg ccctgggtga gaccccagat ctaccagaga ttcctggtgc tattccagtc   1740

caaggagagg tctttggtac tattttagac caacaagaaa ctcttggtat gagtgggagt   1800

gttgtcccag acttgcctgt cttccttcct gttcctccaa atccaattgc tacctttaat   1860

gctccttcca aatggcctga gccccaaagc actgtctcat atggacttgc agtccagggt   1920

gctatacaga ttttgccttt gggctcagga cacactcctc aatcatcatc aaactcagag   1980

aaaaattcat tacctccagt aatggctata agcaatgtag aaaatgagaa gcaggttcat   2040

ataagcttcc tgccagctaa cactcagggg ttcccattag cccctgagag aggactcttc   2100

catgcttcac tgggtatagc ccaactctct caggctggtc ctagcaaatc agacagaggg   2160

agctcccagg tcagtgtaac cagcacagtt catgttgtca acaccacagt ggtgactatg   2220

ccagtgccaa tggtcagtac ctcctcttct tcctatacca ctttgctacc gactttggaa   2280

aagaagaaaa gaaagcgatg tggggtctgt gaaccctgcc agcagaagac caactgtggt   2340

gaatgcactt actgcaagaa cagaaagaac agccatcaga tctgtaagaa aagaaaatgt   2400

gaggagctga aaaagaaacc atctgttgtt gtgcctctgg aggttataaa ggaaaacaag   2460

aggccccaga gggaaaagaa gcccaaagtt ttaaaggcag attttgacaa caaaccagta   2520

aatggcccca agtcagaatc catggactac agtagatgtg gtcatgggga agaacaaaaa   2580

ttggaattga acccacatac tgttgaaaat gtaactaaaa atgaagacag catgacaggc   2640

atcgaggtgg agaagtggac acaaaacaag aaatcacagt taactgatca cgtgaaagga   2700

gattttagtg ctaatgtccc agaagctgaa aaatcgaaaa actctgaagt tgacaagaaa   2760

cgaaccaaat ctccaaaatt gtttgtacaa accgtaagaa atggcattaa acatgtacac   2820

tgtttaccag ctgaaacaaa tgtttcattt aaaaaattca atattgaaga attcggcaag   2880

acattggaaa acaattctta taaattccta aaagacactg caaaccataa aaacgctatg   2940

agctctgttg ctactgatat gagttgtgat catctcaagg ggagaagtaa cgttttagta   3000

ttccagcagc ctggctttaa ctgcagttcc attccacatt cttcacactc catcataaat   3060

catcatgcta gtatacacaa tgaaggtgat caaccaaaaa ctcctgagaa tataccaagt   3120

aaagaaccaa aagatggatc tcccgttcaa ccaagtctct tatcgttaat gaaagatagg   3180

agattaacat tggagcaagt ggtagccata gaggccctga ctcaactctc agaagcccca   3240

tcagagaatt cctccccatc aaagtcagag aaggatgagg aatcagagca gagaacagcc   3300

agtttgctta atagctgcaa agctatcctc tacactgtaa gaaaagacct ccaagaccca   3360

aacttacagg gagagccacc aaaacttaat cactgtccat ctttggaaaa acaaagttca   3420

tgcaacacgg tggttttcaa tgggcaaact actacccttt ccaactcaca tatcaactca   3480

gctactaacc aagcatccac aaagtcacat gaatattcaa aagtcacaaa ttcattatct   3540

ctttttatac caaaatcaaa ttcatccaag attgacacca ataaaagtat tgctcaaggg   3600

ataattactc ttgacaattg ttccaatgat ttgcatcagt tgccaccaag aaataatgaa   3660

gtggagtatt gcaaccagtt actggacagc agcaaaaaat tggactcaga tgatctatca   3720

tgtcaggatg caacccatac ccaaattgag gaagatgttg caacacagtt gacacaactt   3780

gcttcgataa ttaagatcaa ttatataaaa ccagaggaca aaaaagttga aagtacacca   3840

acaagccttg tcacatgtaa tgtacagcaa aaatacaatc aggagaaggg cacaatacaa   3900

cagaaaccac cttcaagtgt acacaataat catggttcat cattaacaaa acaaaagaac   3960

ccaacccaga aaaagacaaa atccacccca tcaagagatc ggcggaaaaa gaagcccaca   4020

gttgtaagtt atcaagaaaa tgatcggcag aagtgggaaa agttgtccta tatgtatggc   4080

acaatatgcg acatttggat agcatcgaaa tttcaaaatt ttgggcaatt ttgtccacat   4140

gattttccta ctgtatttgg gaaaatttct tcctcgacca aaatatggaa accactggct   4200

caaacgaggt ccattatgca acccaaaaca gtatttccac cactcactca gataaaatta   4260

cagagatatc ctgaatcagc agaggaaaag gtgaaggttg aaccattgga ttcactcagc   4320

ttatttcatc ttaaaacgga atccaacggg aaggcattca ctgataaagc ttataattct   4380

caggtacagt taacggtgaa tgccaatcag aaagcccatc ctttgaccca gccctcctct   4440

ccacctaacc agtgtgctaa cgtgatggca ggcgatgacc aaatacggtt tcagcaggtt   4500

gttaaggagc aactcatgca tcagagactg ccaacattgc ctggtatctc tcatgaaaca   4560

cccttaccgg agtcagcact aactctcagg aatgtaaatg tagtgtgttc aggtggaatt   4620

acagtggttt ctaccaaaag tgaagaggaa gtctgttcat ccagttttgg aacatcagaa   4680

ttttccacag tggacagtgc acagaaaaat tttaatgatt atgccatgaa cttctttact   4740

aaccctacaa aaaacctagt gtctataact aaagattctg aactgcccac ctgcagctgt   4800

cttgatcgag ttatacaaaa agacaaaggc ccatattata cacaccttgg ggcaggacca   4860

agtgttgctg ctgtcaggga aatcatggag aataggtatg gtcaaaaagg aaacgcaata   4920

aggatagaaa tagtagtgta caccggtaaa gaagggaaaa gctctcatgg gtgtccaatt   4980

gctaagtggg ttttaagaag aagcagtgat gaagaaaaag ttctttgttt ggtccggcag   5040

cgtacaggcc accactgtcc aactgctgtg atggtggtgc tcatcatggt gtgggatggc   5100

atccctcttc caatggccga ccggctatac acagagctca cagagaatct aaagtcatac   5160

aatgggcacc ctaccgacag aagatgcacc ctcaatgaaa atcgtacctg tacatgtcaa   5220

ggaattgatc cagagacttg tggagcttca ttctcttttg gctgttcatg gagtatgtac   5280

tttaatggct gtaagtttgg tagaagccca agccccagaa gatttagaat tgatccaagc   5340

tctcccttac atgaaaaaaa ccttgaagat aacttacaga gtttggctac acgattagct   5400

ccaatttata agcagtatgc tccagtagct taccaaaatc aggtggaata tgaaaatgtt   5460

gcccgagaat gtcggcttgg cagcaaggaa ggtcgtccct tctctggggt cactgcttgc   5520

ctggacttct gtgctcatcc ccacagggac attcacaaca tgaataatgg aagcactgtg   5580

gtttgtacct taactcgaga agataaccgc tctttgggtg ttattcctca agatgagcag   5640

ctccatgtgc tacctcttta taagctttca gacacagatg agtttggctc caaggaagga   5700

atggaagcca agatcaaatc tggggccatc gaggtcctgg caccccgccg caaaaaaaga   5760

acgtgtttca ctcagcctgt tccccgttct ggaaagaaga gggctgcgat gatgacagag   5820

gttcttgcac ataagataag ggcagtggaa aagaaaccta ttccccgaat caagcggaag   5880

aataactcaa caacaacaaa caacagtaag ccttcgtcac tgccaacctt agggagtaac   5940

actgagaccg tgcaacctga agtaaaaagt gaaaccgaac cccattttat cttaaaaagt   6000

tcagacaaca ctaaaactta ttcgctgatg ccatccgctc ctcacccagt gaaagaggca   6060

tctccaggct tctcctggtc cccgaagact gcttcagcca caccagctcc actgaagaat   6120

gacgcaacag cctcatgcgg gttttcagaa agaagcagca ctccccactg tacgatgcct   6180

tcgggaagac tcagtggtgc caatgcagct gctgctgatg gccctggcat ttcacagctt   6240

ggcgaagtgg ctcctctccc caccctgtct gctcctgtga tggagcccct cattaattct   6300

gagccttcca ctggtgtgac tgagccgcta acgcctcatc agccaaacca ccagccctcc   6360

ttcctcacct ctcctcaaga ccttgcctct tctccaatgg aagaagatga gcagcattct   6420

gaagcagatg agcctccatc agacgaaccc ctatctgatg accccctgtc acctgctgag   6480

gagaaattgc cccacattga tgagtattgg tcagacagtg agcacatctt tttggatgca   6540

aatattggtg gggtggccat cgcacctgct cacggctcgg ttttgattga gtgtgcccgg   6600

cgagagctgc acgctaccac tcctgttgag caccccaacc gtaatcatcc aacccgcctc   6660

tcccttgtct tttaccagca caaaaaccta aataagcccc aacatggttt tgaactaaac   6720

aagattaagt ttgaggctaa agaagctaag aataagaaaa tgaaggcctc agagcaaaaa   6780

gaccaggcag ctaatgaagg tccagaacag tcctctgaag taaatgaatt gaaccaaatt   6840

ccttctcata aagcattaac attaacccat gacaatgttg tcaccgtgtc cccttatgct   6900

ctcacacacg ttgcggggcc ctataaccat tgggtctgaa ggcttttctc cccctcttaa   6960

tgcctttgct agtgcagtgt attttttcaa ggtgctgtta aaagaaagtc atgttgtcgt   7020

ttactatctt catctcaccc atttcaagtc tgaggtaaaa aaataataat gataacaaaa   7080

cggggtgggt attcttaact gtgactatat tttgacaatt ggtagaaggt gcacatttta   7140

agcaaaaata aaagttttat agttttaaat acataaagaa atgtttcagt taggcattaa   7200

ccttgataga atcactcagt ttggtgcttt aaattaagtc tgtttactat gaaacaagag   7260

tcatttttag aggattttaa caggttcatg ttctatgatg taaaatcaag acacacagtg   7320

ttaactctac acagcttctg gtgcttaacc acatccacac agttaaaaat aagctgaatt   7380

attatttcat ggtgccattg ttccaacatc ttccaatcat tgctagaaaa ttggcatatt   7440

cctttgaaat aaacttatga aatgttttct ctcttaaaat atttctcctg tgtaaaataa   7500

atcattgttg ttagtaatgg ttggaggctg ttcataaatt gtaaatatat attttaaaag   7560

cactttctat ttttaaaagt aacttgaaat aatatagtat aagaatccta ttgtctattg   7620

tttgtgcata tttgcataca agagaaatca tttatccttg ctgtgtagag ttccatcttg   7680

ttaactgcag tatgtattct aatcatgtat atggtttgtg ttcttttact gtgtcctctc   7740

acattcaagt attagcaact tgcagtatat aaaatagtta gataatgaga agttgttaat   7800

tatctctaaa attggaatta ggaagcatat caccaatact gattaacatt ctctttggaa   7860

ctaggtaaga gtggtctctt cttattgaac aacctcaatt tagtttcatc ccacctttct   7920

cagtataatc catgagaggt gtttccaaaa ggagatgagg gaacaggata ggtttcagaa   7980

gagtcaaatg cttctaatgt ctcaaggtga taaaatacaa aaactaagta gacagatatt   8040

tgtactgaag tctgatacag aattagaaaa aaaaaattct tgttgaaata ttttgaaaac   8100

aaattcccta ctatcatcac atgcctcccc aaccccaagt caaaaacaag aggaatggta   8160

ctacaaacat ggctttgtcc attaagagct aattcatttg tttatcttag catactagat   8220

ttgggaaaat gataactcat cttttctgat aattgcctat gttctaggta acaggaaaac   8280

aggcattaag tttattttag tcttcccatt ttcttcctat tactttattg actcatttta   8340

ttgcaaaaca aaaaggatta cccaaacaac atgtttcgaa caaggagaat tttcaatgaa   8400

atacttgatt ctgttaaaat gcagaggtgc tataacattc aaagtgtcag attccttggg   8460

agtatggaaa acctaatggt gcttctccct tggaaatgcc ataggaagcc cacaaccgct   8520

aacacttaca attttggtgc aaaagcaaac agttccagca ggctctctaa agaaaaactc   8580

attgtaactt attaaaataa tatctggtgc aaagtatctg ttttgagctt ttgactaatc   8640

caagtaaagg aatatgaagg gattgtaaaa aacaaaatgt ccattgatag accatcgtgt   8700

acaagtagat ttctgcttgt tgaatatgta aaatagggta attcattgac ttgttttagt   8760

attttgtgtg ccttagattt ccgttttaag acatgtatat ttttgtgagc ctaaggtttc   8820

ttatatacat ataagtatat aaataagtga ttgtttattg cttcagctgc ttcaacaaga   8880

tatttactag tattagacta tcaggaatac acccttgcga gattatgttt tagattttag   8940

gccttagctc ccactagaaa ttatttcttc accagattta atggataaag ttttatggct   9000

ctttatgcat ccactcatct actcattctt cgagtctaca cttattgaat gcctgcaaaa   9060

tctaagtatc acttttattt ttctttggat caccacctat gacatagtaa acttgaagaa   9120

taaaaactac cctcagaaat atttttaaaa gaagtagcaa attatcttca gtataatcca   9180

tggtaatgta tgcagtaatt caaattgatc tctctctcaa taggtttctt aacaatctaa   9240

acttgaaaca tcaatgttaa tttttggaac tattgggatt tgtgacgctt gttgcagttt   9300

accaaaacaa gtatttgaaa atatatagta tcaactgaaa tgtttccatt ccgttgttgt   9360

agttaacatc atgaatggac ttcttaagct gattacccca ctgtgggaac caaattggat   9420

tcctactttg ttggactctc tttcctgatt ttaacaattt accatcccat tctctgccct   9480

gtgatttttt ttaaaagctt attcaatgtt ctgcagcatt gtgattgtat gctggctaca   9540

ctgcttttag aatgctcttt ctcatgaagc aaggaaataa atttgtttga aatgacattt   9600

tctctcataa aa                                                       9612


<210>  3
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Molecule 36 Tip1


<220>
<221>  DISULFID
<222>  (1)..(14)

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<400>  3

Tyr Leu Ile Tyr Ala Tyr Tyr Thr Trp Trp Glu His Ser Cys 
1               5                   10                  


<210>  4
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Molecule 37 Tip2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (1)..(13)

<400>  4

Tyr Trp Tyr Leu Pro Ser Tyr Arg Val Pro Trp Phe Cys 
1               5                   10              


<210>  5
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  Molecule 38 Tip3m15L


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  ACETYLATION

<220>
<221>  DISULFID
<222>  (1)..(17)

<400>  5

Tyr Tyr Arg Val Lys Thr Tyr Tyr Gln Ile Thr Tyr Val Tyr Leu Ser 
1               5                   10                  15      


Cys 
    


