                         SEQUENCE LISTING

<110>  Randox Laboratories Ltd
 
<120>  IMMUNE CHECKPOINT INHIBITOR

<130>  JWJ02661WO

<140>  EP20205559.6
<141>  2020-11-03

<160>  36     

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 31.1A1

<400>  1

Arg Thr Phe Arg Glu Tyr Gly Met Gly 
1               5                   


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 31.1A1

<400>  2

Thr Ile Ser Ser Ser Gly Ser Tyr Ser Tyr 
1               5                   10  


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 31.1A1

<400>  3

Ala Ala Ser Ser Leu Leu Arg Gly Ser Ser Ser Arg Ala Glu Ser Tyr 
1               5                   10                  15      


Asp Ser 
        


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 32.2F7

<400>  4

Arg Thr Phe Arg Glu Tyr Gly Met Gly 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 32.2F7

<400>  5

Thr Ile Ser Ser Ser Gly Ser Tyr Thr Tyr 
1               5                   10  


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 32.2F7

<400>  6

Ala Ala Ser Ser Leu Leu Arg Gly Ser Ser Ser Arg Ala Glu Pro Tyr 
1               5                   10                  15      


Asp Ser 
        


<210>  7
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length antibody-CDRs 1-3

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Glu Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ser Gly Ser Tyr Ser Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Leu Leu Arg Gly Ser Ser Ser Arg Ala Glu Ser Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  8
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length antibody-CDRs 4-6

<400>  8

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Arg Glu Tyr 
            20                  25                  30          


Gly Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Ser Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ser Ser Leu Leu Arg Gly Ser Ser Ser Arg Ala Glu Pro Tyr 
            100                 105                 110         


Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  9
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 47.9E3

<400>  9

Ser Ile Phe Arg Gly Asn Ala Met Val 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 47.9E3

<400>  10

Thr Ile Thr Asn Gly Gly Ser Thr Asn 
1               5                   


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 47.9E3

<400>  11

Asn Asp Val Ile Arg Gly Glu Ser Gly Ile Tyr Tyr Pro Leu Asn Tyr 
1               5                   10                  15      


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 32.1C7

<400>  12

Leu Ala Phe Ala Thr His Thr Met Gly 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 32.1C7

<400>  13

Gly Ala Pro Trp Asn Asp Asn Ile Glu 
1               5                   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 32.1C7

<400>  14

Ala Val Thr Thr Arg Leu Leu Arg Thr Ser Tyr Ala Glu Gln Tyr Pro 
1               5                   10                  15      


Tyr 
    


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 46.2D2

<400>  15

Ser Thr Phe Ser Asn Ile Tyr Met Gly 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 46.2D2

<400>  16

Arg Ile Ser Ser Gly Gly Ser Thr Asn 
1               5                   


<210>  17
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 46.2D2

<400>  17

Met Arg Leu Ile Ser Gly Ala Ser Gly Trp Phe Pro Leu Asp Tyr 
1               5                   10                  15  


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 46.2B12

<400>  18

Arg Thr Val Ser Asn Asp Asp Val Gly 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 46.2B12

<400>  19

Arg Ile Asp Ser Asp Gly Ser Thr Asn 
1               5                   


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 46.2B12

<400>  20

Met Arg Leu Val Ser Gly Ala Ser Gly Trp Phe Pro Leu Asp Tyr 
1               5                   10                  15  


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 46.3C10

<400>  21

Thr Thr Phe Ser Asn Asn Asp Met Gly 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 46.3C10

<400>  22

Arg Ile Ser Ser Gly Gly Ser Thr Thr 
1               5                   


<210>  23
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 46.3C10

<400>  23

Met Arg Leu Val Leu Gly Thr Ser Gly Trp Phe Pro Leu Asp Tyr 
1               5                   10                  15  


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 46.4B10

<400>  24

Ile Ser Asn Thr Glu Asn Thr Met Gly 
1               5                   


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 46.4B10

<400>  25

Leu Ile Ser Asn Ser Gly Leu Ile Thr His 
1               5                   10  


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 46.4B10

<400>  26

Tyr Ile Ser Thr Asp Pro Pro Thr 
1               5               


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 46.4H7

<400>  27

Ser Thr Phe Ser Asn Asp Tyr Ile Gly 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 46.4H7

<400>  28

Arg Ile Ser Ser Ser Gly Ser Thr Asn 
1               5                   


<210>  29
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 46.4H7

<400>  29

Met Arg Glu Ile Ser Gly Ala Ser Gly Trp Phe Pro Leu Asp Tyr 
1               5                   10                  15  


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 46.2D2.D12.D5

<400>  30

Ile Ser Asn Thr Glu Asn Thr Met Gly 
1               5                   


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 46.2D2.D12.D5

<400>  31

Leu Ile Ser Asn Ser Gly Leu Ile Thr His 
1               5                   10  


<210>  32
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 46.2D2.D12.D5

<400>  32

Tyr Ile Ser Thr Glu Pro Pro Thr 
1               5               


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1 of Clone ID 46.2D2.H7

<400>  33

Ser Thr Phe Ser Asn Pro Tyr Met Gly 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2 of Clone ID 46.2D2.H7

<400>  34

Arg Ile Ser Ser Gly Gly Ser Thr Asn 
1               5                   


<210>  35
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 46.2D2.H7

<400>  35

Met Arg Leu Ile Ser Gly Ala Ser Gly Trp Phe Pro Leu Asp Tyr 
1               5                   10                  15  


<210>  36
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3 of Clone ID 31.1A1


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  36

Xaa Ser Leu Leu Arg Gly Xaa Ser Ser Arg Ala Glu Xaa Tyr Asp Xaa 
1               5                   10                  15      

