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<110>  ҽҩ޹˾                               

<120>  -5'-øĿ 
                       
<160>  41                                  
 
<170>  PatentIn version 3.1  

<210>  1                                  

<211>  9                               

<212>  PRT                                   

<213>  СMus musculus                      

<400>  1 
Gly His Ser Ile Thr Ser Asp Tyr Val
1                5
                                    
<210>  2                                  

<211>  7                               

<212>  PRT                                   

<213>  СMus musculus

<400>  2
Ile Ser Tyr Ser Gly Ile Ile
1                5

<210>  3                                  

<211>  10                               

<212>  PRT                                   

<213>  СMus musculus

<400>  3 
Ala Gly Asp Glu Tyr Phe Trp Phe Ala Tyr
1                5                  10 

<210>  4                                  

<211>  6                               

<212>  PRT                                   

<213>  СMus musculus

<400>  4
Gln Asp Ile Lys Ser Tyr
1	         5

<210>  5                                  

<211>  3                               

<212>  PRT                                   

<213>  СMus musculus

<400>  5
Tyr Ala Thr
1

<210>  6                                  

<211>  9                                

<212>  PRT                                   

<213>  СMus musculus

<400>  6
Leu Gln His Gly Glu Ser Pro Tyr Thr
1                5

<210>  7                                  

<211>  116                               

<212>  PRT                                   

<213>  СMus musculus

<400>  7 
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser
1                5                  10                  15
Leu Ser Leu Thr Cys Thr Val Thr Gly His Ser Ile Thr Ser Asp Tyr
            20                  25                  30    
Val Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
        35                  40                  45   
Gly Tyr Ile Ser Tyr Ser Gly Ile Ile Lys Tyr Asn Pro Ser Leu Lys 
    50                  55                  60  
Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80        
Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95
Gly Asp Glu Tyr Phe Trp Phe Ala Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110
Thr Val Ser Ser
        115

<210>  8                                  

<211>  107                               

<212>  PRT                                   

<213>  СMus musculus

<400>  8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1                5                  10                  15 
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30
Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45   
Tyr Tyr Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60        
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80
Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Tyr 
                85                  90                  95  
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105
 

<210>  9                                  

<211>  8                               

<212>  PRT                                   

<213>  СMus musculus

<400>  9
Gly Tyr Thr Phe Thr Asp Tyr Tyr
1                5
      
<210>  10                                  

<211>  8                               

<212>  PRT                                   

<213>  СMus musculus

<400>  10
Thr Tyr Pro Gly Asn Gly Asn Thr
1                5

<210>  11                                  

<211>  14                               

<212>  PRT                                   

<213>  СMus musculus

<400>  11
Ala Arg Gly Thr Tyr Tyr Gly Ser Ser Glu Tyr Phe Asp Tyr
1                5                  10        

<210>  12                                  

<211>  6                               

<212>  PRT                                   

<213>  СMus musculus

<400>  12
Gln Asn Val Gly Thr Ala
1                5

<210>  13                                  

<211>  3                               

<212>  PRT                                   

<213>  СMus musculus

<400>  13
Ser Ala Ser
1

<210>  14                                  

<211>  9 
                              
<212>  PRT                                   

<213>  СMus musculus

<400>  14
Gln Gln Tyr Ser Ser Tyr Ile Phe Thr
1                5

<210>  15                                  

<211>  120                               

<212>  PRT                                   

<213>  СMus musculus

<400>  15
Val Lys Leu Gln Glu Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala Ser 
1                5                  10                  15
Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr 
            20                  25                  30           
Ile Asn Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile Gly 
        35                  40                  45   
Glu Thr Tyr Pro Gly Asn Gly Asn Thr Tyr Tyr His Glu Lys Phe Lys 
    50                  55                  60  
Gly Lys Ala Thr Leu Thr Ala Asp Arg Ser Ser Ser Thr Ala Tyr Met 
65                  70                  75                  80
Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
                85                  90                  95
Arg Gly Thr Tyr Tyr Gly Ser Ser Glu Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110
Gly Thr Thr Val Thr Val Ser Ser
        115                 120

<210>  16                                  

<211>  107                               

<212>  PRT                                   

<213>  СMus musculus

<400>  16
Asp Ile Val Met Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Gly 
1                5                  10                  15
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Ala 
            20                  25                  30 
Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45  
Tyr Ser Ala Ser Asn Arg Asn Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Met Gln Ser 
65                  70                  75                  80
Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Ile Phe 
                85                  90                  95 
Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Asn
            100                 105

<210>  17                                  

<211>  8                               

<212>  PRT                                   

<213>  СMus musculus

<400>  17
Gly Tyr Thr Phe Thr Ser Tyr Trp
1                5

<210>  18                                  

<211>  8                              

<212>  PRT                                   

<213>  СMus musculus

<400>  18
Ile Asn Pro Ser Asn Gly Arg Thr
1                5

<210>  19                                 

<211>  12                              

<212>  PRT                                   

<213>  СMus musculus

<400>  19
Ala Arg Arg Gly Thr Ser Gly Asn Phe Phe Asp Tyr
1                5                  10 

<210>  20                                  

<211>  6                               

<212>  PRT                                   

<213>  СMus musculus

<400>  20
Gln Asp Ile Asn Thr Tyr
1	         5

<210>  21                                  

<211>  3                               

<212>  PRT                                   

<213>  СMus musculus

<400>  21
Arg Ala Asn
1

<210>  22                                  

<211>  9                               

<212>  PRT                                   

<213>  СMus musculus

<400>  22
Leu Gln Phe Asp Glu Phe Pro Tyr Thr
1                5

<210>  23                                  

<211>  119                               

<212>  PRT                                   

<213>  СMus musculus

<400>  23
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1                5                  10                  15
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45          
Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60   
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80 
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95
Ala Arg Arg Gly Thr Ser Gly Asn Phe Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110       
Thr Thr Leu Thr Val Ser Ser
        115

<210>  24                                  

<211>  107                               

<212>  PRT                                   

<213>  СMus musculus

<400>  24
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1                5                  10                  15
Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr
            20                  25                  30  
Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45  
Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60        
Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80
Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Phe Asp Glu Phe Pro Tyr 
                85                  90                  95
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105

<210>  25                                  

<211>  8                               

<212>  PRT                                   

<213>  СMus musculus

<400>  25
Gly Tyr Thr Phe Ala Asp Tyr Phe
1               5

<210>  26                                  

<211>  8                               

<212>  PRT                                   

<213>  СMus musculus

<400>  26
Ile Tyr Pro Gly Tyr Val Asn Ile
1                5

<210>  27                                  

<211>  12                               

<212>  PRT                                   

<213>  СMus musculus

<400>  27
Ala Arg Gly Glu Asp Tyr Asp Ser Ala Met Asp Tyr
1                5                  10 

<210>  28                                  

<211>  11                               

<212>  PRT                                   

<213>  СMus musculus

<400>  28
Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr
1	         5                  10

<210>  29                                  

<211>  3                               

<212>  PRT                                   

<213>  СMus musculus

<400>  29
Lys Val Ser
1

<210>  30                                  

<211>  10                               

<212>  PRT                                   

<213>  СMus musculus

<400>  30
Ser Gln Ser Thr His Val Pro Pro Trp Thr
1                5                  10

<210>  31                                  

<211>  119                               

<212>  PRT                                   

<213>  СMus musculus

<400>  31
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1                5                  10                  15
Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ala Asp Tyr 
            20                  25                  30
Phe Met His Trp Val Arg Leu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45            
Gly Trp Ile Tyr Pro Gly Tyr Val Asn Ile Lys Tyr Asn Glu Lys Phe 
    50                  55                  60       
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95
Ala Arg Gly Glu Asp Tyr Asp Ser Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110
Thr Ser Val Thr Val Ser Ser
        115 

<210>  32                                  

<211>  113                               

<212>  PRT                                   

<213>  СMus musculus

<400>  32
Gly Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1                5                  10                  15
Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45  
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95 
Thr His Val Pro Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile
            100                 105                 110  
Lys

<210>  33                                  

<211>  10                             

<212>  PRT                                

<213>  СMus musculus

<400>  33
Gly Phe Ser Leu Ser Thr Ser Gly Met Gly
1                5                  10

<210>  34                                  

<211>  7                             

<212>  PRT                                  

<213>  СMus musculus

<400>  34
Ile Tyr Trp Asp Asp Asp Lys
1                5

<210>  35                                  

<211>  12                               

<212>  PRT                                   

<213>  СMus musculus

<400>  35
Ala Arg Arg Arg Ser Leu Asp Gly Trp Phe Ala Tyr
1                5                  10 

<210>  36                                  

<211>  6                               

<212>  PRT                                   

<213>  СMus musculus

<400>  36
Gly Asn Ile His Asn Tyr
1                5

<210>  37                                  

<211>  3                             

<212>  PRT                                   

<213>  СMus musculus

<400>  37
Asn Thr Gln
1

<210>  38                                  

<211>  9               
                
<212>  PRT                                   

<213>  СMus musculus

<400>  38
Gln His Phe Trp Asp Ser Pro Trp Thr
1                5               

<210>  39                                  

<211>  120                               

<212>  PRT                                   

<213>  СMus musculus

<400>  39
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1                5                  10                  15
Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30
Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45
Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60        
Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Ser Asn Gln Val 
65                  70                  75                  80
Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95
Cys Ala Arg Arg Arg Ser Leu Asp Gly Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110
Gly Thr Leu Val Thr Val Ser Ala
        115                 120

<210>  40                                  

<211>  107                               

<212>  PRT                                   

<213>  СMus musculus

<400>  40
Asp Ile Gln Met Thr Gln Ser Pro Ala Ala Leu Ser Ala Ser Val Gly 
1                5                  10                  15
Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30  
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45         
Tyr Asn Thr Gln Ile Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60              
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80
Glu Asp Phe Gly Thr Phe Tyr Cys Gln His Phe Trp Asp Ser Pro Trp 
                85                  90                  95 
Thr Phe Gly Gly Gly Thr Lys Met Glu Ile Lys
            100                 105

<210>  41                                  

<211>  527                               

<212>  PRT                                   

<213>  ˹                      

<400>  41
Trp Glu Leu Thr Ile Leu His Thr Asn Asp Val His Ser Arg Leu Glu 
1                5                  10                  15
Gln Thr Ser Glu Asp Ser Ser Lys Cys Val Asn Ala Ser Arg Cys Met 
            20                  25                  30  
Gly Gly Val Ala Arg Leu Phe Thr Lys Val Gln Gln Ile Arg Arg Ala
        35                  40                  45         
Glu Pro Asn Val Leu Leu Leu Asp Ala Gly Asp Gln Tyr Gln Gly Thr 
    50                  55                  60              
Ile Trp Phe Thr Val Tyr Lys Gly Ala Glu Val Ala His Phe Met Asn 
65                  70                  75                  80
Ala Leu Arg Tyr Asp Ala Met Ala Leu Gly Asn His Glu Phe Asp Asn 
                85                  90                  95 
Gly Val Glu Gly Leu Ile Glu Pro Leu Leu Lys Glu Ala Lys Phe Pro 
            100                 105                 110
Ile Leu Ser Ala Asn Ile Lys Ala Lys Gly Pro Leu Ala Ser Gln Ile 
        115                 120                 125
Ser Gly Leu Tyr Leu Pro Tyr Lys Val Leu Pro Val Gly Asp Glu Val 
    130                 135                 140   
Val Gly Ile Val Gly Tyr Thr Ser Lys Glu Thr Pro Phe Leu Ser Asn 
145                 150                 155                 160
Pro Gly Thr Asn Leu Val Phe Glu Asp Glu Ile Thr Ala Leu Gln Pro 
                165                 170                 175             
Glu Val Asp Lys Leu Lys Thr Leu Asn Val Asn Lys Ile Ile Ala Leu 
            180                 185                 190   
Gly His Ser Gly Phe Glu Met Asp Lys Leu Ile Ala Gln Lys Val Arg 
        195                 200                 205  
Gly Val Asp Val Val Val Gly Gly His Ser Asn Thr Phe Leu Tyr Thr 
    210                 215                 220  
Gly Asn Pro Pro Ser Lys Glu Val Pro Ala Gly Lys Tyr Pro Phe Ile 
225                 230                 235                 240
Val Thr Ser Asp Asp Gly Arg Lys Val Pro Val Val Gln Ala Tyr Ala 
                245                 250                 255
Phe Gly Lys Tyr Leu Gly Tyr Leu Lys Ile Glu Phe Asp Glu Arg Gly 
            260                 265                 270   
Asn Val Ile Ser Ser His Gly Asn Pro Ile Leu Leu Asn Ser Ser Ile 
        275                 280                 285   
Pro Glu Asp Pro Ser Ile Lys Ala Asp Ile Asn Lys Trp Arg Ile Lys 
    290                 295                 300      
Leu Asp Asn Tyr Ser Thr Gln Glu Leu Gly Lys Thr Ile Val Tyr Leu 
305                 310                 315                 320
Asp Gly Ser Ser Gln Ser Cys Arg Phe Arg Glu Cys Asn Met Gly Asn 
                325                 330                 335
Leu Ile Cys Asp Ala Met Ile Asn Asn Asn Leu Arg His Thr Asp Glu 
            340                 345                 350
Met Phe Trp Asn His Val Ser Met Cys Ile Leu Asn Gly Gly Gly Ile 
        355                 360                 365         
Arg Ser Pro Ile Asp Glu Arg Asn Asn Gly Thr Ile Thr Trp Glu Asn 
    370                 375                 380             
Leu Ala Ala Val Leu Pro Phe Gly Gly Thr Phe Asp Leu Val Gln Leu 
385                 390                 395                 400
Lys Gly Ser Thr Leu Lys Lys Ala Phe Glu His Ser Val His Arg Tyr 
                405                 410                 415
Gly Gln Ser Thr Gly Glu Phe Leu Gln Val Gly Gly Ile His Val Val 
            420                 425                 430
Tyr Asp Leu Ser Arg Lys Pro Gly Asp Arg Val Val Lys Leu Asp Val 
        435                 440                 445         
Leu Cys Thr Lys Cys Arg Val Pro Ser Tyr Asp Pro Leu Lys Met Asp 
    450                 455                 460   
Glu Val Tyr Lys Val Ile Leu Pro Asn Phe Leu Ala Asn Gly Gly Asp
465                 470                 475                 480
Gly Phe Gln Met Ile Lys Asp Glu Leu Leu Arg His Asp Ser Gly Asp 
                485                 490                 495
Gln Asp Ile Asn Val Val Ser Thr Tyr Ile Ser Lys Met Lys Val Ile 
            500                 505                 510
Tyr Pro Ala Val Glu Gly Arg Ile Lys His His His His His His
        515                 520                 525
