﻿序列表

<110>  南京北恒生物科技有限公司
       江苏浦珠生物医药科技有限公司
 
<120>  靶向LIR1的抗体及其用途

<130>  BHPCT18

<160>  42  

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-L1

<400>  1
Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His
                5                   10


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-L2

<400>  2
Tyr Ala Ser Glu Ser Ile Ser
                5


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-L3

<400>  3
Gln Gln Ser Tyr Ser Trp Pro Tyr Thr
                5                   


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-H1

<400>  4
Gly Phe Ser Leu Ser Thr Ser Gly Leu
                5


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-H2

<400>  5
Trp Trp Asp Asp Asp
                5


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-H3

<400>  6
Thr Glu Leu Gly Arg Gly Asp Tyr
                5                                  


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  LIR1 scFv-1 VL

<400>  7
Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly
                5                   10                  15

Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
            20                  25                  30

Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
        35                  40                  45

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Glu Ser
65                  70                  75                  80

Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Tyr Ser Trp Pro Tyr
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys
            100                 105                 


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  LIR1 scFv-1 VH

<400>  8
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln
                5                   10                  15

Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30

Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
        35                  40                  45

Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Leu Pro Ser
    50                  55                  60

Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val
65                  70                  75                  80

Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
                85                  90                  95

Cys Ala Arg Thr Glu Leu Gly Arg Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110

Ser Val Ala Val Ser Ser      
        115


<210>  9
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  LIR1 scFv-1 scFv

<400>  9
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln
                5                   10                  15

Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30

Gly Leu Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu
        35                  40                  45

Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Leu Pro Ser
    50                  55                  60

Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val
65                  70                  75                  80

Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr
                85                  90                  95

Cys Ala Arg Thr Glu Leu Gly Arg Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110

Ser Val Ala Val Ser Ser Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly
        115                 120                 125

Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile Leu Leu Thr Gln Ser Pro 
    130                 135                 140

Ala Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg 
145                 150                 155                 160

Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr 
                165                 170                 175

Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
            180                 185                 190

Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205

Leu Thr Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys 
    210                 215                 220

Gln Gln Ser Tyr Ser Trp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240

Glu Ile Lys  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-L1

<400>  10
Gly Tyr Ser Phe Thr Asn Tyr
                5             


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-L2

<400>  11
Tyr Pro Gly Asn Ser Asp
                5

     
<210>  12
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-L3

<400>  12
Tyr Asp Gly Tyr Tyr Ser Ala Trp Phe Ala Tyr
                5                   10


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-H1

<400>  13
Lys Ala Ser Gln Asp Val Ser Thr Ala Val Ala
                5                   10


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-H2

<400>  14
Ser Ala Ser Tyr Arg Tyr Thr
                5
                

<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR-H3

<400>  15
Gln Gln His Tyr Ser Pro Pro Trp Thr
                5
     
<210>  16
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  LIR1 scFv-2 VL

<400>  16
Glu Val Gln Leu Gln Gln Ser Gly Thr Val Leu Pro Arg Pro Gly Ala
                5                   10                  15

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr
            20                  25                  30

Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45

Gly Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe
    50                  55                  60

Glu Gly Lys Ala Lys Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr
65                  70                  75                  80

Met Glu Leu Ser Ser Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95

Thr Thr Tyr Asp Gly Tyr Tyr Ser Ala Trp Phe Ala Tyr Trp Gly Gln
            100                 105                 110

Gly Thr Leu Val Thr Val Ser Ala Ala
        115                 120


<210>  17
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  LIR1 scFv-2 VH

<400>  17
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
                5                   10                  15

Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45

Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65                  70                  75                  80

Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Trp
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  18
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  LIR1 scFv-2 scFv

<400>  18
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
                5                   10                  15

Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile
        35                  40                  45

Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly
    50                  55                  60

Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala
65                  70                  75                  80

Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Trp
                85                  90                  95

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly Gly Gly Gly
            100                 105                 110

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
        115                 120                 125

Gln Ser Gly Thr Val Leu Pro Arg Pro Gly Ala Ser Val Lys Met Ser 
    130                 135                 140

Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr Trp Met His Trp Val 
145                 150                 155                 160

Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Ala Ile Tyr Pro 
                165                 170                 175

Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Glu Gly Lys Ala Lys 
            180                 185                 190

Leu Thr Ala Val Thr Ser Ala Ser Thr Ala Tyr Met Glu Leu Ser Ser 
        195                 200                 205

Leu Thr Asn Glu Asp Ser Ala Val Tyr Tyr Cys Thr Thr Tyr Asp Gly 
    210                 215                 220

Tyr Tyr Ser Ala Trp Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
225                 230                 235                 240

Val Ser Ala Ala                
                

<210>  19
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  LIR1 scFv-1 scFv

<400>  19
caggttactc tcaaggaaag tgggcctgga atcttgaagc cgagtcagac tctcagcctg     60

acctgttctt ttagtggatt ctcactcagt acctctggtt tgggagtggg atggattcga    120

cagccgagcg gcaaagggct ggaatggttg gcacacattt ggtgggacga cgacaagtac    180

tatctgcctt ccctcaaaag tcaactcact atatcaaaag acacgtcccg caaccaagtc    240

ttcctgaaga taacatctgt agataccgcc gacacagcta cttactactg tgcacgaacc    300

gaactcgggc gaggtgatta ttggggccag gggactagcg tggcagttag tagcggcagc    360

accagcggca gcggcaaacc gggcagcggc gaaggcagca ccaaaggcga tattctgctt    420

acccaatccc cggcgattct ttcagtgtca cccggggaaa gggtttcatt cagttgcagg    480

gcctcccagt ctattggtac gaatattcat tggtatcagc aaaggacgaa tggtagccca    540

cgacttctga ttaaatacgc tagcgaatcc atcagtggca taccgagtcg ctttagcggt    600

tcaggtagcg gcacggactt cactctgact atcaacagtg ttgagagcga ggacattgca    660

gattattatt gccaacaatc atacagctgg ccctatactt tcggcggcgg tacgaaactc    720

gaaataaaa                                                            729


<210>  20
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  LIR1 scFv-2 scFv

<400>  20
gaagttcagt tgcagcaaag tgggaccgtt ttgccccgcc caggggcttc cgtaaagatg     60

tcctgcaaag caagcggtta ctcatttacg aattactgga tgcactgggt taaacagcgc    120

cccgggcagg gcctggagtg gataggcgct atttaccccg gtaattcaga cacgtcatac    180

aaccagaaat tcgaaggaaa agcaaagttg actgcggtca cttctgcatc aactgcttat    240

atggaattgt cctccctgac caatgaggat tcagcggtat attactgcac gacctacgat    300

gggtactact ccgcatggtt cgcttactgg ggtcaaggaa cgctcgttac tgttagcgca    360

gctggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcga catcgttatg    420    

acccaatccc acaaattcat gagcacttca gttggcgaca gggtttcaat cacttgcaag    480

gcgtctcagg atgtcagcac cgcggttgct tggtaccaac agaaaccagg acaaagccca    540

aagcttctta tttattcagc aagctatcgg tatactggtg ttccagatcg gttcacggga    600

agcgggtctg gcacagactt cacttttacg atcagctctg ttcaagcgga agatcttgca    660

ctctactatt gtcaacaaca ctactcaccg ccctggacct ttgggggagg aactaagttg    720

gagatcaagc gc                                                        732


<210>  21
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α跨膜结构域

<400>  21
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                5                   10                  15

Ser Leu Val Ile Thr Leu Tyr Cys Lys
            20                  25


<210>  22
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α跨膜结构域

<400>  22
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     60

accctttact gcaaa                                                      75


<210>  23
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28跨膜结构域

<400>  23
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                5                   10                  15

Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25


<210>  24
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28跨膜结构域

<400>  24
ttttgggtcc tcgtcgtagt tggaggggta cttgcctgtt atagcctcct ggttaccgta     60

gcatttatta tattctgggt g                                               81


<210>  25
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28共刺激结构域

<400>  25
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                5                   10                  15

Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30

Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40


<210>  26
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28共刺激结构域

<400>  26
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc    120

tcc                                                                  123


<210>  27
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  4-1BB共刺激结构域

<400>  27
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                5                   10                  15

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
            20                  25                  30

Glu Glu Glu Glu Gly Gly Cys Glu
        35                  40


<210>  28
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  4-1BB共刺激结构域

<400>  28
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     60

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     120


<210>  29
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ信号传导结构域

<400>  29
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                5                   10                  15

Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60

Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
65                  70                  75                  80

Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                85                  90                  95

Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            100                 105                 110

Arg


<210>  30
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ信号传导结构域

<400>  30
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac    180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag    240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac    300

acctacgacg cccttcacat gcaggccctg ccccctcgc                           339


<210>  31
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ信号传导结构域

<400>  31
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln
                5                   10                  15

Gly Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Phe Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
    50                  55                  60

Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
65                  70                  75                  80

Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser
                85                  90                  95

Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro
            100                 105                 110

Pro Arg


<210>  32
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ信号传导结构域

<400>  32
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctttaacg agctcaatct aggacgaaga gaggagttcg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg    180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc    240

gagcgccgga ggggcaaggg gcacgatggc cttttccagg gtctcagtac agccaccaag    300

gacacctttg acgcccttca catgcaggcc ctgccccctc gc                       342


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  B2M信号肽

<400>  33
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser
                5                   10                  15

Gly Leu Glu Ala
            20


<210>  34
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  B2M信号肽

<400>  34
atgtcccgct ctgttgcttt ggctgtgctg gcccttttgt cccttagcgg actggaggcc     60


<210>  35
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α信号肽

<400>  35
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
                5                   10                  15

His Ala Ala Arg Pro
            20


<210>  36
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α信号肽

<400>  36
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccg                                                                   63


<210>  37
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α铰链区

<400>  37
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
                5                   10                  15

Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30

Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
        35                  40                  45


<210>  38
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α铰链区

<400>  38
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg     60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    120

gacttcgcct gtgat                                                     135


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28铰链区

<400>  39
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
                5                   10                  15

Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30

Phe Pro Gly Pro Ser Lys Pro
        35


<210>  40
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28铰链区

<400>  40
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc     60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc       117


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  IgG4铰链区

<400>  41
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
                5                   10


<210>  42
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  IgG4铰链区

<400>  42
gaaagcaaat acgggccgcc gtgtccaccc tgtccg                               36


