                         SEQUENCE LISTING

<110>  EXPRESSION THERAPEUTICS, LLC
       EMORY UNIVERSITY
       CHILDREN'S HEALTHCARE OF ATLANTA, INC.
 
<120>  CLOTTING FACTOR VARIANTS AND THEIR USE

<130>  103-800PCT

<150>  US 63/110,449
<151>  2020-11-06

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  461
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(461)
<223>  Human fIX

<400>  1

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe Asn Lys Gly Arg Ser Ala Ser Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  2
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An96 fIX

<400>  2

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Thr Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Arg Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Arg Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Lys Lys Leu Thr Arg 
            180                 185                 190         


Ala Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala 
        195                 200                 205             


Glu Thr Ile Leu Asp Asn Val Thr Gln Ser Thr Gln Ser Phe Asn Asp 
    210                 215                 220                 


Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro 
225                 230                 235                 240 


Trp Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser 
                245                 250                 255     


Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro 
            260                 265                 270         


Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Lys Thr 
        275                 280                 285             


Glu Pro Thr Glu Gln Lys Arg Asn Val Ile Arg Val Ile Pro His His 
    290                 295                 300                 


Asn Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys 
                325                 330                 335     


Ile Ala Asn Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly 
            340                 345                 350         


Tyr Val Ser Gly Trp Gly Arg Val Phe Asn Arg Gly Arg Ser Ala Ser 
        355                 360                 365             


Ile Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu 
    370                 375                 380                 


Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Tyr 
385                 390                 395                 400 


His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His 
                405                 410                 415     


Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp 
            420                 425                 430         


Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
        435                 440                 445             


Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460         


<210>  3
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96sp3pro - hfIX with An96 Signal Peptide, 
       Propetide, and Protease Domains

<400>  3
atgcagtgcc tgaacatgat catggccgag tcccccggcc tgatcaccat ctgcctgctg       60

gggtacctgc tgagcgccga gtgcaccgtg ttcctggacc acgagaacgc caccaagatc      120

ctgaacaggc ccaagagata caattctgga aagctggagg aatttgtgca gggcaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ctagggaggt gtttgaaaac      240

acagagagga ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgtgacct gtaacatcaa gaatggcagg      420

tgtgagcagt tctgtaaaaa ctctgctgat aataaggtgg tctgcagctg tacagaaggc      480

tataggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gagaacgcta agccaggaca gttcccatgg      720

caggtgctgc tgaacgggaa gatcgacgcc ttctgcggcg ggtccatcat caacgagaag      780

tgggtggtga ccgctgctca ctgcatcgag ccaggagtga agatcaccgt ggtggctggg      840

gagcacaaca tcgagaagac cgagcccacc gagcagaagc gcaacgtgat ccgcgtgatc      900

ccccaccaca actacaacgc caccatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  4
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: An96-hfIXpro - An96 with hfIX Protease Domain

<400>  4
atgcagtgcc tgaacatgat catggccgag tcccccggcc tgatcaccat ctgcctgctg       60

gggtacctgc tgagcgccga gtgcaccgtg ttcctggacc acgagaacgc caccaagatc      120

ctgaacaggc ccaagagata caactccggc aagctggagg agttcgtgag ggggaacctg      180

gagagagagt gcatcgagga gaagtgcagc ttcgaggagg ccagggaggt gttcgagaac      240

accgagaaga ccaccgagtt ctggaagcag tacgtggacg gcgaccagtg cgagtccaac      300

ccctgcctga acggcgggtc ctgcaaggac gacatcaaca gctacgagtg ctggtgcagg      360

ttcggcttcg aggggaagaa ctgcgagctg gacgccacct gcagcatcaa gaacggcaga      420

tgcaagcagt tctgcaagaa gtccgccgac aacaaggtgg tgtgcagctg caccgaggga      480

tacagactgg ctgaggacca gaagtcctgc gagccagctg tgccattccc atgcgggagg      540

gtgtccgtga gccacaccag caagaagctg accagagccg aaaccatctt ctccaacatg      600

gactacgaga acagcaccga ggccgaaacc atcctggaca acgtgaccca gtccacccag      660

agcttcaacg acttcacccg ggtggtggga ggagaggatg ccaaaccagg ccagttcccc      720

tggcaggtgg tcctgaatgg gaaggtggat gctttttgtg ggggatccat tgtgaatgag      780

aaatggattg tcacagctgc tcactgtgtg gagacagggg tcaagatcac tgtggtggct      840

ggagagcaca acattgagga aacagaacat actgagcaga agaggaatgt gatcagaatc      900

atccctcacc ataactacaa tgctgctatc aacaaatata atcatgacat tgccctgctg      960

gaactggatg agcctctggt gctgaacagc tatgtcaccc caatctgcat tgctgacaaa     1020

gagtatacca atatcttcct gaagtttgga tctggatatg tgtctggatg gggaagggtc     1080

ttccacaagg gcaggtctgc cctggtgctg cagtatctga gggtgcctct ggtggacaga     1140

gctacctgcc tgaggtctac caagttcacc atctacaaca atatgttctg tgctggattt     1200

catgagggag gcagggactc ctgtcagggg gattctggag gcccacatgt gacagaggtg     1260

gaaggcacca gcttcctgac tggcatcatc tcttgggggg aggaatgtgc tatgaagggg     1320

aaatatggaa tctacaccaa agtgagcagg tatgtgaact ggatcaaaga gaagaccaaa     1380

ctgacctga                                                             1389


<210>  5
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96appro - hfIX with An96 Activation Peptide and 
       Protease Domains

<400>  5
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caattctgga aagctggagg aatttgtgca gggcaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ctagggaggt gtttgaaaac      240

acagagagga ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgtgacct gtaacatcaa gaatggcagg      420

tgtgagcagt tctgtaaaaa ctctgctgat aataaggtgg tctgcagctg tacagaaggc      480

tataggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagccgaaa ccatcttctc caacatggac      600

tacgagaaca gcaccgaggc cgaaaccatc ctggacaacg tgacccagtc cacccagagc      660

ttcaacgact tcacccgggt ggtgggagga gagaacgcta agccaggaca gttcccatgg      720

caggtgctgc tgaacgggaa gatcgacgcc ttctgcggcg ggtccatcat caacgagaag      780

tgggtggtga ccgctgctca ctgcatcgag ccaggagtga agatcaccgt ggtggctggg      840

gagcacaaca tcgagaagac cgagcccacc gagcagaagc gcaacgtgat ccgcgtgatc      900

ccccaccaca actacaacgc caccatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  6
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96e2pro - hfIX with An96 EGF2 and Protease 
       Domains

<400>  6
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caattctgga aagctggagg aatttgtgca gggcaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ctagggaggt gtttgaaaac      240

acagagagga ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gacgccacct gcagcatcaa gaacggcaga      420

tgcaagcagt tctgcaagaa gtccgccgac aacaaggtgg tgtgcagctg caccgaggga      480

tacagactgg ctgaggacca gaagtcctgc gagccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gagaacgcta agccaggaca gttcccatgg      720

caggtgctgc tgaacgggaa gatcgacgcc ttctgcggcg ggtccatcat caacgagaag      780

tgggtggtga ccgctgctca ctgcatcgag ccaggagtga agatcaccgt ggtggctggg      840

gagcacaaca tcgagaagac cgagcccacc gagcagaagc gcaacgtgat ccgcgtgatc      900

ccccaccaca actacaacgc caccatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  7
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96e2V86A - hfIX containing EGF2 V86A Amino Acid 
       Substitution from An96

<400>  7
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caattctgga aagctggagg aatttgtgca gggcaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ctagggaggt gtttgaaaac      240

acagagagga ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgccacct gtaacatcaa gaatggcagg      420

tgtgagcagt tctgtaaaaa ctctgctgat aataaggtgg tctgcagctg tacagaaggc      480

tataggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gaggatgcca aaccaggcca gttcccctgg      720

caggtggtcc tgaatgggaa ggtggatgct ttttgtgggg gatccattgt gaatgagaaa      780

tggattgtca cagctgctca ctgtgtggag acaggggtca agatcactgt ggtggctgga      840

gagcacaaca ttgaggaaac agaacatact gagcagaaga ggaatgtgat cagaatcatc      900

cctcaccata actacaatgc tgctatcaac aaatataatc atgacattgc cctgctggaa      960

ctggatgagc ctctggtgct gaacagctat gtcaccccaa tctgcattgc tgacaaagag     1020

tataccaata tcttcctgaa gtttggatct ggatatgtgt ctggatgggg aagggtcttc     1080

cacaagggca ggtctgccct ggtgctgcag tatctgaggg tgcctctggt ggacagagct     1140

acctgcctga ggtctaccaa gttcaccatc tacaacaata tgttctgtgc tggatttcat     1200

gagggaggca gggactcctg tcagggggat tctggaggcc cacatgtgac agaggtggaa     1260

ggcaccagct tcctgactgg catcatctct tggggggagg aatgtgctat gaaggggaaa     1320

tatggaatct acaccaaagt gagcaggtat gtgaactgga tcaaagagaa gaccaaactg     1380

acctga                                                                1386


<210>  8
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96e2V86Apro2 - hfIX containing EGF2 V86A Amino 
       Acid Substitution and Pro2 from An96

<400>  8
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caattctgga aagctggagg aatttgtgca gggcaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ctagggaggt gtttgaaaac      240

acagagagga ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgccacct gtaacatcaa gaatggcagg      420

tgtgagcagt tctgtaaaaa ctctgctgat aataaggtgg tctgcagctg tacagaaggc      480

tataggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gaggatgcca aaccaggcca gttcccctgg      720

caggtggtcc tgaatgggaa ggtggatgct ttttgtgggg gatccattgt gaatgagaaa      780

tggattgtca cagctgctca ctgtgtggag acaggggtca agatcactgt ggtggctgga      840

gagcacaaca ttgaggaaac agaacatact gagcagaaga ggaatgtgat cagaatcatc      900

cctcaccata actacaatgc tgctatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  9
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96ge2appro - hfIX with An96 Gla, EGF2, Activation
       Peptide, and Protease Domains

<400>  9
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caactccggc aagctggagg agttcgtgag ggggaacctg      180

gagagagagt gcatcgagga gaagtgcagc ttcgaggagg ccagggaggt gttcgagaac      240

accgagaaga ccaccgagtt ctggaagcag tacgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gacgccacct gcagcatcaa gaacggcaga      420

tgcaagcagt tctgcaagaa gtccgccgac aacaaggtgg tgtgcagctg caccgaggga      480

tacagactgg ctgaggacca gaagtcctgc gagccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagccgaaa ccatcttctc caacatggac      600

tacgagaaca gcaccgaggc cgaaaccatc ctggacaacg tgacccagtc cacccagagc      660

ttcaacgact tcacccgggt ggtgggagga gagaacgcta agccaggaca gttcccatgg      720

caggtgctgc tgaacgggaa gatcgacgcc ttctgcggcg ggtccatcat caacgagaag      780

tgggtggtga ccgctgctca ctgcatcgag ccaggagtga agatcaccgt ggtggctggg      840

gagcacaaca tcgagaagac cgagcccacc gagcagaagc gcaacgtgat ccgcgtgatc      900

ccccaccaca actacaacgc caccatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  10
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96ge2pro - hfIX with An96 Gla, EGF2, and Protease
       Domains

<400>  10
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caactccggc aagctggagg agttcgtgag ggggaacctg      180

gagagagagt gcatcgagga gaagtgcagc ttcgaggagg ccagggaggt gttcgagaac      240

accgagaaga ccaccgagtt ctggaagcag tacgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gacgccacct gcagcatcaa gaacggcaga      420

tgcaagcagt tctgcaagaa gtccgccgac aacaaggtgg tgtgcagctg caccgaggga      480

tacagactgg ctgaggacca gaagtcctgc gagccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gagaacgcta agccaggaca gttcccatgg      720

caggtgctgc tgaacgggaa gatcgacgcc ttctgcggcg ggtccatcat caacgagaag      780

tgggtggtga ccgctgctca ctgcatcgag ccaggagtga agatcaccgt ggtggctggg      840

gagcacaaca tcgagaagac cgagcccacc gagcagaagc gcaacgtgat ccgcgtgatc      900

ccccaccaca actacaacgc caccatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  11
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96ge2pro2  - hfIX containing An96 Gla, EGF2, and 
       Pro2 Domains

<400>  11
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caactccggc aagctggagg agttcgtgag ggggaacctg      180

gagagagagt gcatcgagga gaagtgcagc ttcgaggagg ccagggaggt gttcgagaac      240

accgagaaga ccaccgagtt ctggaagcag tacgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gacgccacct gcagcatcaa gaacggcaga      420

tgcaagcagt tctgcaagaa gtccgccgac aacaaggtgg tgtgcagctg caccgaggga      480

tacagactgg ctgaggacca gaagtcctgc gagccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gaggatgcca aaccaggcca gttcccctgg      720

caggtggtcc tgaatgggaa ggtggatgct ttttgtgggg gatccattgt gaatgagaaa      780

tggattgtca cagctgctca ctgtgtggag acaggggtca agatcactgt ggtggctgga      840

gagcacaaca ttgaggaaac agaacatact gagcagaaga ggaatgtgat cagaatcatc      900

cctcaccata actacaatgc tgctatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  12
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96gpro - hfIX with An96 Gla and Protease Domains

<400>  12
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caactccggc aagctggagg agttcgtgag ggggaacctg      180

gagagagagt gcatcgagga gaagtgcagc ttcgaggagg ccagggaggt gttcgagaac      240

accgagaaga ccaccgagtt ctggaagcag tacgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgtgacct gtaacatcaa gaatggcagg      420

tgtgagcagt tctgtaaaaa ctctgctgat aataaggtgg tctgcagctg tacagaaggc      480

tataggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gagaacgcta agccaggaca gttcccatgg      720

caggtgctgc tgaacgggaa gatcgacgcc ttctgcggcg ggtccatcat caacgagaag      780

tgggtggtga ccgctgctca ctgcatcgag ccaggagtga agatcaccgt ggtggctggg      840

gagcacaaca tcgagaagac cgagcccacc gagcagaagc gcaacgtgat ccgcgtgatc      900

ccccaccaca actacaacgc caccatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  13
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96pro - hfIX with An96 Protease Domain

<400>  13
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caattctgga aagctggagg aatttgtgca gggcaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ctagggaggt gtttgaaaac      240

acagagagga ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgtgacct gtaacatcaa gaatggcagg      420

tgtgagcagt tctgtaaaaa ctctgctgat aataaggtgg tctgcagctg tacagaaggc      480

tataggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gagaacgcta agccaggaca gttcccatgg      720

caggtgctgc tgaacgggaa gatcgacgcc ttctgcggcg ggtccatcat caacgagaag      780

tgggtggtga ccgctgctca ctgcatcgag ccaggagtga agatcaccgt ggtggctggg      840

gagcacaaca tcgagaagac cgagcccacc gagcagaagc gcaacgtgat ccgcgtgatc      900

ccccaccaca actacaacgc caccatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  14
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: hfIX-96pro2 - hfIX with An96 second half of Protease 
       Domain

<400>  14
atgcagaggg tcaatatgat catggctgaa tctcctgggc tgatcaccat ttgcctgctg       60

ggatacctgc tgtctgctga gtgtacagtg ttcctggacc atgagaatgc caataagatc      120

ctgaacaggc ccaaaagata caattctgga aagctggagg aatttgtgca gggcaacctg      180

gagagggaat gcatggagga aaagtgtagc tttgaggaag ctagggaggt gtttgaaaac      240

acagagagga ccacagaatt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccctgtctga atggagggtc ttgcaaagat gatatcaact cctatgagtg ctggtgtcct      360

tttggatttg aaggcaaaaa ttgtgagctg gatgtgacct gtaacatcaa gaatggcagg      420

tgtgagcagt tctgtaaaaa ctctgctgat aataaggtgg tctgcagctg tacagaaggc      480

tataggctgg ctgagaacca gaagagctgt gaaccagctg tgcccttccc ttgtgggagg      540

gtgtctgtca gccagacctc taagctgacc agagctgaga ctgtgttccc agatgtggat      600

tatgtcaact ccacagaggc tgaaaccatc ctggacaaca tcacccagtc tacccagtcc      660

ttcaatgact ttaccagagt ggtgggagga gaggatgcca aaccaggcca gttcccctgg      720

caggtggtcc tgaatgggaa ggtggatgct ttttgtgggg gatccattgt gaatgagaaa      780

tggattgtca cagctgctca ctgtgtggag acaggggtca agatcactgt ggtggctgga      840

gagcacaaca ttgaggaaac agaacatact gagcagaaga ggaatgtgat cagaatcatc      900

cctcaccata actacaatgc tgctatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc caacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc ggtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  15
<211>  415
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SITE
<222>  (1)..(415)
<223>  Human fIX

<400>  15

Tyr Asn Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg 
1               5                   10                  15      


Glu Cys Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe 
            20                  25                  30          


Glu Asn Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly 
        35                  40                  45              


Asp Gln Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp 
    50                  55                  60                  


Asp Ile Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys 
65                  70                  75                  80  


Asn Cys Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu 
                85                  90                  95      


Gln Phe Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr 
            100                 105                 110         


Glu Gly Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val 
        115                 120                 125             


Pro Phe Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr 
    130                 135                 140                 


Arg Ala Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu 
145                 150                 155                 160 


Ala Glu Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn 
                165                 170                 175     


Asp Phe Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe 
            180                 185                 190         


Pro Trp Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly 
        195                 200                 205             


Ser Ile Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu 
    210                 215                 220                 


Thr Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu 
225                 230                 235                 240 


Thr Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His 
                245                 250                 255     


His Asn Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu 
            260                 265                 270         


Leu Glu Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile 
        275                 280                 285             


Cys Ile Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser 
    290                 295                 300                 


Gly Tyr Val Ser Gly Trp Gly Arg Val Phe Asn Lys Gly Arg Ser Ala 
305                 310                 315                 320 


Ser Val Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys 
                325                 330                 335     


Leu Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly 
            340                 345                 350         


Phe His Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
        355                 360                 365             


His Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser 
    370                 375                 380                 


Trp Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys 
385                 390                 395                 400 


Val Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
                405                 410                 415 


<210>  16
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An96 fIX Padua

<400>  16

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Thr Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Arg Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Arg Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Lys Lys Leu Thr Arg 
            180                 185                 190         


Ala Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala 
        195                 200                 205             


Glu Thr Ile Leu Asp Asn Val Thr Gln Ser Thr Gln Ser Phe Asn Asp 
    210                 215                 220                 


Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro 
225                 230                 235                 240 


Trp Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser 
                245                 250                 255     


Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro 
            260                 265                 270         


Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Lys Thr 
        275                 280                 285             


Glu Pro Thr Glu Gln Lys Arg Asn Val Ile Arg Val Ile Pro His His 
    290                 295                 300                 


Asn Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys 
                325                 330                 335     


Ile Ala Asn Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly 
            340                 345                 350         


Tyr Val Ser Gly Trp Gly Arg Val Phe Asn Arg Gly Arg Ser Ala Ser 
        355                 360                 365             


Ile Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu 
    370                 375                 380                 


Leu Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Tyr 
385                 390                 395                 400 


His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His 
                405                 410                 415     


Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp 
            420                 425                 430         


Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
        435                 440                 445             


Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460         


<210>  17
<211>  1389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: An96 fIX Padua

<400>  17
atgcagtgcc tgaacatgat catggccgag tcccccggcc tgatcaccat ctgcctgctg       60

gggtacctgc tgagcgccga gtgcaccgtg ttcctggacc acgagaacgc caccaagatc      120

ctgaacaggc ccaagagata caactccggc aagctggagg agttcgtgag ggggaacctg      180

gagagagagt gcatcgagga gaagtgcagc ttcgaggagg ccagggaggt gttcgagaac      240

accgagaaga ccaccgagtt ctggaagcag tacgtggacg gcgaccagtg cgagtccaac      300

ccctgcctga acggcgggtc ctgcaaggac gacatcaaca gctacgagtg ctggtgcagg      360

ttcggcttcg aggggaagaa ctgcgagctg gacgccacct gcagcatcaa gaacggcaga      420

tgcaagcagt tctgcaagaa gtccgccgac aacaaggtgg tgtgcagctg caccgaggga      480

tacagactgg ctgaggacca gaagtcctgc gagccagctg tgccattccc atgcgggagg      540

gtgtccgtga gccacaccag caagaagctg accagagccg aaaccatctt ctccaacatg      600

gactacgaga acagcaccga ggccgaaacc atcctggaca acgtgaccca gtccacccag      660

agcttcaacg acttcacccg ggtggtggga ggagagaacg ctaagccagg acagttccca      720

tggcaggtgc tgctgaacgg gaagatcgac gccttctgcg gcgggtccat catcaacgag      780

aagtgggtgg tgaccgctgc tcactgcatc gagccaggag tgaagatcac cgtggtggct      840

ggggagcaca acatcgagaa gaccgagccc accgagcaga agcgcaacgt gatccgcgtg      900

atcccccacc acaactacaa cgccaccatc aacaagtact cccacgacat cgccctgctg      960

gagctggaca agcccctgac cctgaacagc tacgtgaccc ccatctgcat cgccaacagg     1020

gagtacacca acatcttcct gaagttcgga tccggatacg tgagcggatg gggacgcgtg     1080

ttcaaccgcg gccggtccgc cagcatcctg cagtacctga gagtgccact ggtggacaga     1140

gctacctgcc tgctgtccac caagttcacc atctacaaca acatgttctg cgctggatac     1200

cacgagggag ggaaggactc ctgccagggg gacagcggag gaccacacgt gaccgaggtg     1260

gagggcacct ccttcctgac cggcatcatc agctgggggg aggagtgcgc catgaagggc     1320

aagtacggga tctacaccaa ggtgagcaga tacgtgaact ggatcaagga gaagaccaag     1380

ctgacctga                                                             1389


<210>  18
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An97 fIX Padua

<400>  18

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Arg Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Arg Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Val Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Lys Thr Glu 
        275                 280                 285             


Pro Thr Glu Gln Lys Arg Asn Val Ile Arg Val Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe Asn Arg Gly Arg Ser Ala Ser Ile 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Tyr His 
385                 390                 395                 400 


Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  19
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An63 fIX

<400>  19

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Thr Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Met Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Gln Val Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Gly Ala Asp Asn Lys Val Val Cys Ser Cys Thr Thr Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Lys Lys Leu Thr Arg 
            180                 185                 190         


Ala Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala 
        195                 200                 205             


Glu Thr Ile Leu Asp Asn Val Thr Gln Ser Thr Gln Ser Phe Asn Asp 
    210                 215                 220                 


Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro 
225                 230                 235                 240 


Trp Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser 
                245                 250                 255     


Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro 
            260                 265                 270         


Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Thr Glu Glu Thr 
        275                 280                 285             


Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Val Ile Pro His His 
    290                 295                 300                 


Ser Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys 
                325                 330                 335     


Ile Ala Asn Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly 
            340                 345                 350         


Tyr Val Ser Gly Trp Gly Lys Val Phe Asn Arg Gly Arg Ser Ala Ser 
        355                 360                 365             


Ile Leu Gln Tyr Leu Lys Val Pro Leu Val Asp Arg Ala Thr Cys Leu 
    370                 375                 380                 


Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Tyr 
385                 390                 395                 400 


His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His 
                405                 410                 415     


Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp 
            420                 425                 430         


Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
        435                 440                 445             


Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460         


<210>  20
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An65 fIX

<400>  20

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Thr Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Leu Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Gln Val Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Gly Ala Asp Asn Lys Val Val Cys Ser Cys Thr Thr Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Thr Lys Leu Thr Arg 
            180                 185                 190         


Ala Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala 
        195                 200                 205             


Glu Thr Ile Leu Asp Asn Val Thr Gln Ser Thr Gln Ser Phe Asn Asp 
    210                 215                 220                 


Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro 
225                 230                 235                 240 


Trp Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser 
                245                 250                 255     


Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro 
            260                 265                 270         


Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Thr Glu Glu Thr 
        275                 280                 285             


Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Val Ile Pro His His 
    290                 295                 300                 


Ser Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys 
                325                 330                 335     


Ile Ala Asp Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly 
            340                 345                 350         


Tyr Val Ser Gly Trp Gly Lys Val Phe Asn Arg Gly Arg Ser Ala Ser 
        355                 360                 365             


Ile Leu Gln Tyr Leu Lys Val Pro Leu Val Asp Arg Ala Thr Cys Leu 
    370                 375                 380                 


Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe 
385                 390                 395                 400 


His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His 
                405                 410                 415     


Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp 
            420                 425                 430         


Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
        435                 440                 445             


Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460         


<210>  21
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An70 fIX

<400>  21

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Val Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp Arg Glu Asn Ala Thr Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Arg Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Leu Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Gln Val Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Gly Ala Asp Asn Lys Val Val Cys Ser Cys Thr Thr Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Thr Lys Leu Thr Arg 
            180                 185                 190         


Ala Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala 
        195                 200                 205             


Glu Ile Ile Leu Asp Asn Val Thr Gln Ser Asn Gln Ser Phe Asn Asp 
    210                 215                 220                 


Phe Thr Arg Ile Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro 
225                 230                 235                 240 


Trp Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser 
                245                 250                 255     


Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro 
            260                 265                 270         


Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Thr Glu Glu Thr 
        275                 280                 285             


Glu Pro Thr Glu Gln Lys Arg Asn Val Ile Arg Ala Ile Pro His His 
    290                 295                 300                 


Ser Tyr Asn Ala Thr Val Asn Lys Tyr Ser His Asp Ile Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Asp Glu Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys 
                325                 330                 335     


Ile Ala Asp Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly 
            340                 345                 350         


Tyr Val Ser Gly Trp Gly Lys Val Phe Asn Arg Gly Arg Ser Ala Ser 
        355                 360                 365             


Ile Leu Gln Tyr Leu Lys Val Pro Leu Val Asp Arg Ala Thr Cys Leu 
    370                 375                 380                 


Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe 
385                 390                 395                 400 


His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His 
                405                 410                 415     


Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp 
            420                 425                 430         


Gly Glu Glu Cys Ala Val Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
        435                 440                 445             


Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460         


<210>  22
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An84 fIX

<400>  22

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Thr Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Gln Val Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Gly Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Lys Lys Leu Thr Arg 
            180                 185                 190         


Ala Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala 
        195                 200                 205             


Glu Thr Ile Leu Asp Asn Val Thr Gln Ser Thr Gln Ser Phe Asn Asp 
    210                 215                 220                 


Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro 
225                 230                 235                 240 


Trp Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser 
                245                 250                 255     


Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro 
            260                 265                 270         


Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr 
        275                 280                 285             


Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Val Ile Pro His His 
    290                 295                 300                 


Asn Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys 
                325                 330                 335     


Ile Ala Asn Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly 
            340                 345                 350         


Tyr Val Ser Gly Trp Gly Arg Val Phe Asn Arg Gly Arg Ser Ala Ser 
        355                 360                 365             


Ile Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu 
    370                 375                 380                 


Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Tyr 
385                 390                 395                 400 


His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His 
                405                 410                 415     


Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp 
            420                 425                 430         


Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
        435                 440                 445             


Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460         


<210>  23
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An88 fIX

<400>  23

Met Gln His Leu Asn Thr Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Phe Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Ala Val Phe Leu 
            20                  25                  30          


Asp Arg Glu Asn Ala Thr Lys Ile Leu Thr Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Arg Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Lys Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Gln Val Gly Phe Glu Gly Arg Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Asn Gly Ala Asp Asn Lys Val Ile Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Gln Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Tyr Ser Ser Lys Lys Leu Thr Arg 
            180                 185                 190         


Ala Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala 
        195                 200                 205             


Glu Thr Ile Leu Asp Asn Val Thr Glu Asn Ser Glu Ser Leu Asn Asp 
    210                 215                 220                 


Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Ile Pro 
225                 230                 235                 240 


Trp Gln Val Ile Leu Asn Gly Glu Ile Glu Ala Phe Cys Gly Gly Ala 
                245                 250                 255     


Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Leu Lys Pro 
            260                 265                 270         


Gly Asp Lys Ile Glu Val Val Ala Gly Glu Tyr Asn Ile Asp Glu Lys 
        275                 280                 285             


Glu Asp Thr Glu Gln Arg Arg Asn Val Ile Arg Thr Ile Pro His His 
    290                 295                 300                 


His Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Asp Lys Pro Leu Ile Leu Asn Ser Tyr Val Thr Pro Ile Cys 
                325                 330                 335     


Val Ala Asn Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly 
            340                 345                 350         


Tyr Val Ser Gly Trp Gly Lys Val Phe Asn Lys Gly Arg Gln Ala Ser 
        355                 360                 365             


Ile Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu 
    370                 375                 380                 


Arg Ser Thr Thr Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Tyr 
385                 390                 395                 400 


Arg Glu Gly Gly Lys Asp Ser Cys Glu Gly Asp Ser Gly Gly Pro His 
                405                 410                 415     


Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp 
            420                 425                 430         


Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
        435                 440                 445             


Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460         


<210>  24
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An95 fIX

<400>  24

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Thr Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Gln Val Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Gly Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Lys Lys Leu Thr Arg 
            180                 185                 190         


Ala Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala 
        195                 200                 205             


Glu Thr Ile Leu Asp Asn Val Thr Gln Ser Thr Gln Ser Phe Asn Asp 
    210                 215                 220                 


Phe Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro 
225                 230                 235                 240 


Trp Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser 
                245                 250                 255     


Ile Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro 
            260                 265                 270         


Gly Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr 
        275                 280                 285             


Glu His Thr Glu Gln Lys Arg Asn Val Ile Arg Val Ile Pro His His 
    290                 295                 300                 


Asn Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu 
305                 310                 315                 320 


Glu Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys 
                325                 330                 335     


Ile Ala Asn Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly 
            340                 345                 350         


Tyr Val Ser Gly Trp Gly Arg Val Phe Asn Arg Gly Arg Ser Ala Ser 
        355                 360                 365             


Ile Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu 
    370                 375                 380                 


Arg Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Tyr 
385                 390                 395                 400 


His Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His 
                405                 410                 415     


Val Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp 
            420                 425                 430         


Gly Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val 
        435                 440                 445             


Ser Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460         


<210>  25
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An97 fIX

<400>  25

Met Gln Cys Leu Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Arg Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Ile Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Arg Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Ser Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Lys Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asp Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser His Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Ile Phe Ser Asn Met Asp Tyr Glu Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Val Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asn Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Leu Leu Asn Gly Lys Ile Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Ile Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Pro Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Lys Thr Glu 
        275                 280                 285             


Pro Thr Glu Gln Lys Arg Asn Val Ile Arg Val Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Thr Ile Asn Lys Tyr Ser His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe Asn Arg Gly Arg Ser Ala Ser Ile 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Tyr His 
385                 390                 395                 400 


Glu Gly Gly Lys Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  26
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: An102 fIX

<400>  26

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Lys Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Val Thr Cys Asn Ile Lys Asn Gly Arg Cys Lys Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Val Val Thr Ala Ala His Cys Ile Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Thr Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asp Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe Asn Lys Gly Arg Ser Ala Ser Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  27
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: An97 fIX Padua

<400>  27
atgcagtgcc tgaacatgat catggccgag tcccccggcc tgatcaccat ctgcctgctg       60

gggtacctgc tgagcgccga gtgcaccgtg ttcctggacc acgagaacgc caacaagatc      120

ctgaacaggc ccaagagata caactccggc aagctggagg agttcgtgag ggggaacctg      180

gagagagagt gcatcgagga gaagtgcagc ttcgaggagg ccagggaggt gttcgagaac      240

accgagaaga ccaccgagtt ctggaagcag tacgtggacg gcgaccagtg cgagtccaac      300

ccctgcctga acggcgggtc ctgcaaggac gacatcaaca gctacgagtg ctggtgcagg      360

ttcggcttcg aggggaagaa ctgcgagctg gacgccacct gcagcatcaa gaacggcaga      420

tgcaagcagt tctgcaagaa gtccgccgac aacaaggtgg tgtgcagctg caccgaggga      480

tacagactgg ctgaggacca gaagtcctgc gagccagctg tgccattccc atgcgggagg      540

gtgtccgtga gccacaccag caagctgacc agagccgaaa ccatcttctc caacatggac      600

tacgagaaca gcaccgaggc cgaaaccatc ctggacaacg tgacccagtc cacccagagc      660

ttcaacgact tcacccgggt ggtgggagga gagaacgcta agccaggaca gttcccatgg      720

caggtgctgc tgaacgggaa gatcgacgcc ttctgcggcg ggtccatcat caacgagaag      780

tgggtggtga ccgctgctca ctgcatcgag ccaggagtga agatcaccgt ggtggctggg      840

gagcacaaca tcgagaagac cgagcccacc gagcagaagc gcaacgtgat ccgcgtgatc      900

ccccaccaca actacaacgc caccatcaac aagtactccc acgacatcgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctac gtgaccccca tctgcatcgc cgacagggag     1020

tacaccaaca tcttcctgaa gttcggatcc ggatacgtga gcggatgggg acgcgtgttc     1080

aaccgcggcc ggtccgccag catcctgcag tacctgagag tgccactggt ggacagagct     1140

acctgcctgc tgtccaccaa gttcaccatc tacaacaaca tgttctgcgc tggataccac     1200

gagggaggga aggactcctg ccagggggac agcggaggac cacacgtgac cgaggtggag     1260

ggcacctcct tcctgaccgg catcatcagc tggggggagg agtgcgccat gaagggcaag     1320

tacgggatct acaccaaggt gagcagatac gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  28
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Alpha 1  - No Padua

<400>  28
atgcagaggg tgaacatgat catggctgag tcccctggcc tcatcaccat ctgcctcctg       60

ggctacctcc tgagtgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagaggta caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgctcc tttgaggagg ccagggaggt ctttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gggaccagtg tgagtccaac      300

ccctgcctca atgggggctc ctgcaaggat gacatcaact cctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatgggagg      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgctcctg cactgagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagcctgctg tgcccttccc ctgtgggagg      540

gtgagtgtgt cccagacctc caagctcacc agggctgaga ctgtgttccc tgatgtggac      600

tatgtgaact ccactgaggc tgagaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tcaatggcaa ggtggatgcc ttctgtgggg gctccattgt gaatgagaag      780

tggattgtga ctgctgccca ctgtgtggag acaggggtga agatcacagt ggtggctggg      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctcctggag      960

ctggatgagc ccctggtgct caactcctat gtgaccccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctcaa gtttggctct ggctatgtga gtggctgggg gagggtgttc     1080

cacaagggga ggagtgcctc tgtgctccag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggga gggactcctg ccagggggac tctgggggcc cccatgtgac tgaggtggag     1260

ggcacctcct tcctcactgg catcatctcc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcaggtat gtgaactgga tcaaggagaa gaccaagttg     1380

acctga                                                                1386


<210>  29
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Alpha 2  - No Padua

<400>  29
atgcagaggg tgaacatgat catggctgag tcccctggcc tgatcaccat ctgcctcctg       60

ggctacctgc tgagtgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caactctggg aagctggagg agtttgtcca ggggaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gagaccagtg tgagtccaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg aggggaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa ctctgctgat aacaaggtgg tgtgcagctg cacagagggc      480

tataggctgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcagg      540

gtgagtgtgt cccagacctc caagctgacc agggctgaga cagtcttccc tgatgtggac      600

tatgtcaaca gcacagaggc tgagaccatc ctggacaaca tcacccagtc cacccagagc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agcctgggca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtgggg ggagcattgt caatgagaag      780

tggattgtca cagctgccca ctgtgtggag acaggggtga agatcacagt ggtggctgga      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtcat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtcaccccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtct ctggctgggg cagggtgttc     1080

cacaagggca gatctgcctc tgtcctgcag tacctgaggg tccccctggt ggatagggcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tgggttccat     1200

gaggggggga gggactcctg ccagggggat agtggagggc cccatgtgac agaggtggag     1260

ggcacctcct tcctcacagg catcatctcc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt cagcaggtat gtcaactgga tcaaggagaa gaccaagctc     1380

acctga                                                                1386


<210>  30
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Alpha 3  - No Padua

<400>  30
atgcagaggg tcaacatgat catggctgag agccctgggc tcatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacagac ccaagaggta caactcaggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgctcc tttgaggagg ccagagaggt ctttgagaac      240

acagagagga ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagtccaac      300

ccctgcctga atggaggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctcagctgac aacaaggtgg tgtgcagctg cacagagggc      480

tacagactgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcagg      540

gtctctgtca gccagacctc caagctcacc agagctgaga ctgtgttccc tgatgtggac      600

tatgtgaaca gcacagaggc tgagaccatc ctggacaaca tcacccagag cacccagtcc      660

ttcaatgact tcaccagagt ggtggggggg gaggatgcca agccagggca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtgggg gctccattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggggtca agatcacagt ggtggctgga      840

gagcacaaca tagaggagac agagcacaca gagcagaaga ggaatgtcat caggatcatc      900

ccccaccaca actacaatgc agccatcaac aagtacaacc atgacatagc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtgaccccca tctgcatagc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagggtcttc     1080

cacaagggca gatctgccag tgtgctgcag tacctgagag tgcccctggt ggacagggcc     1140

acctgcctga ggagcactaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gagacagctg ccagggggac tctgggggcc cccatgtgac agaggtggag     1260

ggcaccagct tcctgacagg catcatcagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt cagcagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  31
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Alpha 4  - No Padua

<400>  31
atgcagaggg tgaacatgat catggctgag tcccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caacagtggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gggaccagtg tgagtccaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaact cctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa cagtgctgac aacaaggtgg tgtgctcctg cacagagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagcctgctg tgcccttccc ctgtggcagg      540

gtgtctgtgt cccagacctc caagctgacc agggctgaga cagtgttccc tgatgtggac      600

tatgtgaact ccacagaggc tgagaccatc ctggacaaca tcacccagtc cacccagagc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtgggg gctccatagt gaatgagaag      780

tggattgtga ctgctgccca ctgtgtggag acaggggtga agatcacagt ggtggctggg      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaactcctat gtgaccccca tctgcatagc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggcagt ggctatgtgt ctggctgggg cagggtgttc     1080

cacaagggca ggtctgcctc tgtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggactcctg ccagggggac tctgggggcc cccatgtgac tgaggtggag     1260

ggcacctcct tcctgacagg catcatctcc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcaggtat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  32
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Beta 1  - No Padua

<400>  32
atgcagaggg tgaacatgat catggctgag agccctgggc tgatcaccat ctgcctgctg       60

gggtacctgc tgagtgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagaggta caacagtggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gggaccagtg tgagtccaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa cagtgctgac aacaaggtgg tgtgcagctg cactgagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagcctgcag tgcccttccc ctgtggcagg      540

gtgtctgtgt cccagaccag caagctcacc agggctgaga ctgtgttccc tgatgtggac      600

tatgtcaaca gcacagaggc tgagaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agccagggca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtgggg gcagcattgt caatgagaag      780

tggattgtca cagcagccca ctgtgtggag actggggtga agatcacagt ggtggctggg      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtcat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtcaccccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggcagt ggctatgtca gtggctgggg cagggtgttc     1080

cacaggggca ggtctgccag tgtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctga ggtccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggacagctg ccagggggac tctgggggcc cccatgtcac tgaggtggag     1260

ggcaccagct tcctgacagg catcatcagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt cagcaggtat gtgaactgga tcaaggagaa gaccaagctc     1380

acctga                                                                1386


<210>  33
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Beta 2  - No Padua

<400>  33
atgcagaggg tgaacatgat catggctgag tcccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgctcc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gagaccagtg tgagtccaac      300

ccttgcctga atggaggctc ctgcaaggat gacatcaact cctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgctcctg cacagagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagccagctg tgcccttccc ttgtggcagg      540

gtgtctgtgt cccagacctc caagctgacc agggctgaga cagtgttccc tgatgtggac      600

tatgtgaact ccacagaggc tgagaccatc ctggacaaca tcacccagtc cacccagtcc      660

ttcaatgact tcaccagggt ggtgggaggt gaggatgcca agcctggcca gttcccttgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggag gctccattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggagtga agatcacagt ggtggctggt      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaactcctat gtgaccccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt caggatgggg cagggtgttc     1080

cacaggggca ggtctgcctc tgtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctga ggtccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gggactcctg ccagggtgac tcaggaggcc cccatgtgac agaggtggag     1260

ggcacctcct tcctgacagg catcatcagc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccaggtat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  34
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Beta 3  - No Padua

<400>  34
atgcagagag tcaacatgat catggcagag tcacctggac tgatcaccat ctgcctgctg       60

ggctacctgc tcagtgcaga gtgcacagtc ttcctggacc atgagaatgc caacaagatc      120

ctgaacagac ccaagaggta caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagagagt gcatggagga gaagtgctcc tttgaggagg ccagagaggt ctttgagaac      240

actgagagga ccactgagtt ctggaagcag tatgtggatg gtgatcagtg tgagtccaac      300

ccatgcctga atggaggctc ctgcaaggat gacatcaact cctatgagtg ctggtgccca      360

tttggctttg agggcaagaa ctgtgagctg gatgcaacat gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa cagtgcagac aacaaggtgg tgtgctcctg cacagagggc      480

tacagactgg ctgagaacca gaagtcatgt gagcctgctg tgcccttccc ctgtggcaga      540

gtgagtgtgt cccagaccag caagctgacc agagctgaga cagtcttccc tgatgtggac      600

tatgtgaact ccacagaggc agagaccatc ctggacaaca tcacacagtc cacacagtcc      660

ttcaatgact tcaccagagt ggttggtggt gaggatgcca agcctggaca gttcccctgg      720

caggtggtgc tcaatggcaa ggtggatgcc ttctgtggag gctccattgt caatgagaag      780

tggattgtca cagctgccca ctgtgtggag actggtgtga agatcactgt ggtggctggt      840

gagcacaaca ttgaggagac agagcacact gagcagaaga ggaatgtcat caggatcatc      900

ccacaccaca actacaatgc agccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtgaccccca tctgcatagc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtcttc     1080

cacagaggca gatctgcctc tgtgctgcag tacctgagag tgcctctggt ggacagagca     1140

acctgcctga gaagcaccaa gttcaccatc tacaacaaca tgttctgtgc aggcttccat     1200

gagggaggca gagactcctg ccagggagac tctggtgggc cacatgtgac agaggtggag     1260

ggcacatcct tcctgacagg catcatctcc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccaggtat gtcaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  35
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Beta 4  - No Padua

<400>  35
atgcagagag tgaacatgat catggctgag tcccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggatc atgagaatgc caacaagatc      120

ctgaacagac ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagagagt gcatggagga gaagtgctcc tttgaggagg ccagagaggt gtttgagaac      240

acagagagaa ccacagagtt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccttgcctga atggaggctc ctgcaaggat gatatcaact cctatgagtg ctggtgccca      360

tttggctttg agggcaagaa ttgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgat aacaaggtgg tgtgctcctg cacagagggc      480

tacagactgg ctgagaacca gaagtcctgt gagcctgctg tgcctttccc ttgtggcaga      540

gtgtctgtgt cccagacctc caagctgacc agagctgaga cagtgttccc tgatgtggat      600

tatgtgaact ccacagaggc tgagaccatc ctggataaca tcacccagtc cacccagtcc      660

ttcaatgatt tcaccagagt ggtgggagga gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggag gctccattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggagtga agatcacagt ggtggctgga      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga gaaatgtgat cagaatcatc      900

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgatattgc cctgctggag      960

ctggatgagc ccctggtgct gaactcctat gtgaccccta tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtgttc     1080

cacagaggca gatctgcctc tgtgctgcag tacctgagag tgcctctggt ggatagagcc     1140

acctgcctga gatccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagattcctg ccagggagat tctggaggcc ctcatgtgac agaggtggag     1260

ggcacctcct tcctgacagg catcatctcc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  36
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Delta 1  - No Padua

<400>  36
atgcagaggg tgaacatgat catggcagag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtcagcaga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caacagtggc aagctggagg agtttgtcca gggcaacctg      180

gagagggagt gcatggagga gaagtgctcc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga caacagagtt ctggaagcag tatgttgatg gtgaccagtg tgagagcaac      300

ccctgcctga atggtggctc ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa cagtgctgac aacaaggtgg tgtgctcctg cacagagggc      480

tacaggctgg cagagaacca gaagagctgt gagcctgctg tccccttccc ctgtggcagg      540

gtgtcagtgt cccagaccag caagctgacc agggcagaga cagtgttccc tgatgttgac      600

tatgtcaaca gcacagaggc agagaccatc ctggacaaca tcacccagag cacccagtcc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggtg gcagcattgt caatgagaag      780

tggatagtga cagctgccca ctgtgtggag acaggggtga agataacagt ggtggcaggg      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtcat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggacaagc ccctgaccct gaacagctat gtcaccccca tctgcattgc caacagggag     1020

tacaccaaca tcttcctgaa gtttggcagt ggctatgtct ctggctgggg cagggtgttc     1080

cacaggggca ggagtgccag tgtcctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggacagctg ccagggggac agtggtggcc cccatgtgac agaggtggag     1260

ggcacctcct tcctgacagg catcatctcc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcaggtat gtcaactgga tcaaggagaa gaccaagctg     1380

acatga                                                                1386


<210>  37
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Delta 2  - No Padua

<400>  37
atgcagaggg tcaacatgat catggctgag tcacctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caacagtggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt ctttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gtgaccagtg tgagagcaac      300

ccctgcctga atggtggctc ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa cagtgctgac aacaaggtgg tgtgcagctg cacagagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagcctgctg tgccattccc ctgtggcagg      540

gtcagtgtca gccagaccag caagctgacc agggctgaga cagtgttccc tgatgtggac      600

tatgtgaaca gcacagaggc tgagaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagagt ggtgggtggt gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tcaatggcaa ggtggatgcc ttctgtggtg gcagcattgt caatgagaag      780

tggattgtca cagctgcaca ctgtgtggag acaggtgtca agatcacagt ggtggctggt      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

ccacaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc actgctggag      960

ctggacaagc cactgaccct gaacagctat gtgaccccca tctgcattgc caacagggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtca gtggctgggg cagggtgttc     1080

cacagaggca ggtctgccag tgtgctgcag tacctgaggg tgccactggt ggacagggcc     1140

acctgcctca ggtccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggtggca gggacagctg ccagggtgac tctggtggcc cacatgtgac agaggtggag     1260

ggcaccagct tcctgacagg catcatcagc tggggtgagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt cagcaggtat gtcaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  38
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Delta 3  - No Padua

<400>  38
atgcagaggg tcaacatgat catggctgag tcaccaggct tgatcaccat ctgcctgctg       60

ggctacctgc tgtcagctga gtgcacagtg tttcttgacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagaggta caacagtggc aagctggagg agtttgtcca aggcaacctg      180

gagagagagt gcatggagga gaagtgcagc tttgaggagg ccagagaggt gtttgagaac      240

actgagagga ccactgagtt ctggaagcag tatgtggatg gtgaccagtg tgagtccaac      300

ccctgtctca atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctt gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa ctcagctgac aacaaggtgg tgtgcagctg cactgagggc      480

tacaggctgg ctgagaacca gaagagctgt gagccagctg tgcccttccc ctgtggcagg      540

gtgagtgtga gccagaccag caagctgacc agggctgaga cagtgttccc tgatgttgac      600

tatgtcaaca gcactgaggc tgagaccatc ttggacaaca tcactcagtc aacccagagc      660

ttcaatgact tcaccagggt ggtggggggt gaggatgcta agccaggcca gttcccctgg      720

caggtggtgc tcaatggcaa ggttgatgcc ttctgtggtg gctcaattgt caatgagaag      780

tggattgtga cagctgccca ctgtgttgag actggggtca agatcacagt ggtggctggt      840

gagcacaaca ttgaggagac tgagcacact gagcagaaga ggaatgtgat caggatcatc      900

cctcatcaca actacaatgc tgccatcaac aagtacaatc atgacatagc cctgcttgag      960

cttgacaagc ccctgaccct caacagctat gtcaccccca tctgcattgc caacagggag     1020

tacaccaaca tcttcctcaa gtttggctca ggctatgtct caggctgggg cagggtgttc     1080

cacaggggca ggtcagcctc agtgctgcag tacctcaggg tgccactggt ggacagggcc     1140

acctgcctga ggtcaaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gagacagctg ccagggtgac tcaggtgggc cccatgtgac tgaggttgag     1260

ggcaccagct tcctcactgg catcatcagc tggggtgagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcaggtat gtcaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  39
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Delta 4  - No Padua

<400>  39
atgcagagag tcaacatgat catggctgag tcccctgggc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtc ttcctggacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagaggta caactcaggc aagctggagg agtttgtcca gggcaacctg      180

gagagagagt gcatggagga gaagtgctcc tttgaggagg ccagagaggt ctttgagaac      240

acagagagaa ccacagagtt ctggaagcag tatgtggatg gtgaccagtg tgagagcaac      300

ccctgcctga atggaggctc ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgcagac aacaaggtgg tctgcagctg cacagagggc      480

tacaggctgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcaga      540

gtgtcagtca gccagaccag caagctgacc agagcagaga cagtcttccc tgatgtggac      600

tatgtgaact ccacagaggc agagaccatc ctggataaca tcacccagag cactcagagc      660

ttcaatgatt tcaccagggt ggtgggtggt gaggatgcca agcctggcca gttcccctgg      720

caggtggtcc tgaatggcaa ggtggatgcc ttctgtggag gctccattgt gaatgagaag      780

tggattgtca ctgctgctca ctgtgtggag acaggagtga agatcactgt ggtggctgga      840

gagcacaaca tagaggagac agagcacaca gagcagaaga gaaatgtcat caggatcatc      900

ccccatcaca actacaatgc agccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggacaagc ccctcaccct gaactcctat gtgactccca tctgcattgc caacagagag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtgttc     1080

cacaggggca ggtctgccag tgtgctgcag tacctcagag tgcccctggt ggacagagcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagatagctg ccagggtgac tctggaggcc cccatgtgac tgaggtggag     1260

ggcacctcct tcctgacagg catcatctcc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcaggtat gtcaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  40
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Gamma 1  - No Padua

<400>  40
atgcagaggg tcaacatgat catggcagag tcccctgggc tcatcaccat ctgcctcctg       60

gggtacctgc tcagtgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caactctggg aaactggagg agtttgtcca ggggaacctg      180

gagagggagt gcatggagga gaagtgctcc tttgaggagg ccagggaggt ctttgagaac      240

acagagagga ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagtccaac      300

ccctgcctca atgggggcag ctgcaaggat gacatcaact cctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgcagctg cactgagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagccagctg tgcccttccc ctgtggcaga      540

gtctcagtgt cccagacctc caagctgacc agagctgaga cagtgttccc agatgtggac      600

tatgtgaact ccacagaggc tgagaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagggt ggtgggagga gaagatgcca agcctgggca gttcccctgg      720

caggtggtgc tcaatggcaa agtggatgcc ttctgtggag gctccattgt caatgagaag      780

tggattgtca cagctgccca ctgtgtggag acaggggtca agatcacagt ggtggcaggg      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggacaagc ccctggtgct gaactcctat gtgaccccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct gggtatgtct caggctgggg cagagtgttc     1080

cacaggggca gaagtgcctc agtgctgcag tacctcaggg tgcccctggt ggacagggcc     1140

acttgcctca ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc agggttccat     1200

gaggggggca gggactcctg ccagggggac tctgggggcc cccatgtcac agaggtggag     1260

ggcaccagtt tcctcacagg gatcatctcc tggggtgagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccaggtat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  41
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Gamma 2  - No Padua

<400>  41
atgcagaggg tcaacatgat catggctgag agccctggcc tcatcaccat ctgcctgctg       60

ggctacctgc tgtcagctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagaggta caacagtggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga caacagagtt ctggaagcag tatgttgatg gtgaccagtg tgagagcaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctt gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa cagtgctgac aacaaggtgg tgtgcagctg cacagagggc      480

tacaggctgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcagg      540

gtgtctgtga gccagacaag caagctgacc agggctgaga cagtgttccc tgatgttgac      600

tatgtcaaca gcacagaggc tgagaccatc ctggacaaca tcacacagtc aacacagagc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggttgatgcc ttctgtgggg gcagcattgt caatgagaag      780

tggattgtga cagctgccca ctgtgttgag acaggggtca agatcacagt ggtggctggt      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtcat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacatagc cctgctggag      960

cttgacaagc ccctggtgct caacagctat gtgaccccca tctgtatagc caacaaggag     1020

tacaccaaca tcttcctcaa gtttggctca ggctatgtgt caggctgggg cagggtgttc     1080

cacaggggca ggtcagcctc tgtgctgcag tacctgaggg tgcccctggt tgacagggcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggacagctg ccagggtgac agtgggggcc ctcatgtgac agaggttgag     1260

ggcaccagct tcctgacagg catcatcagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcaggtat gtcaactgga tcaaggagaa gaccaagctg     1380

acatga                                                                1386


<210>  42
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Gamma 3  - No Padua

<400>  42
atgcagagag tgaacatgat catggctgag tcacctggac tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtc ttcctggatc atgagaatgc caacaagatc      120

ctgaacagac ctaagaggta caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagagagt gcatggagga gaagtgcagc tttgaggagg ccagagaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gtgatcagtg tgagagcaac      300

ccctgcctga atggaggcag ctgcaaggat gatatcaact cctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa cagtgctgat aacaaggtgg tgtgcagctg cacagagggc      480

tacagactgg ctgagaacca gaagagctgt gagccagctg tgcccttccc ctgtggcaga      540

gtgtcagtgt cacagaccag caagctgacc agagctgaga cagtcttccc tgatgtggac      600

tatgtgaaca gcacagaggc tgagaccatc ctggataaca tcacccagtc cacccagtca      660

ttcaatgact tcaccagagt ggtgggagga gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgca ttctgtggag gcagcattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggtgtga agatcacagt ggtggctgga      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgatattgc actgctggag      960

ctggataagc cactggtgct gaacagctat gtgacaccta tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggcagt ggctatgtgt caggctgggg cagagtgttc     1080

cacagaggca gatcagcctc tgtgctgcag tacctgagag tgccactggt ggatagagcc     1140

acctgcctga ggagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagatagctg ccagggtgac agtggtggcc ctcatgtgac agaggtggag     1260

ggcacctcct tcctgactgg catcatctcc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acatga                                                                1386


<210>  43
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence Gamma 4  - No Padua

<400>  43
atgcagagag tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggatc atgagaatgc caacaagatc      120

ctgaacagac ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagagagt gcatggagga gaagtgctcc tttgaggagg ccagagaggt gtttgagaac      240

acagagagaa ccacagagtt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccttgcctga atggaggctc ctgcaaggat gatatcaact cctatgagtg ctggtgccct      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgat aacaaggtgg tgtgctcctg cacagagggc      480

tacagactgg ctgagaacca gaagtcctgt gagcctgctg tgcccttccc ttgtggcaga      540

gtgtctgtgt cccagacctc caagctgacc agagctgaga cagtgttccc tgatgtggat      600

tatgtgaact ccacagaggc tgagaccatc ctggataaca tcacccagtc cacccagtcc      660

ttcaatgatt tcaccagagt ggtgggagga gaggatgcca agcctggcca gttcccttgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggag gctccattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggagtga agatcacagt ggtggctgga      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga gaaatgtgat cagaatcatc      900

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgatattgc cctgctggag      960

ctggataagc ctctggtgct gaactcctat gtgacaccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtgttc     1080

cacagaggca gatctgcctc tgtgctgcag tacctgagag tgcctctggt ggatagagcc     1140

acctgcctga gatccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagattcctg ccagggagat tctggaggcc ctcatgtgac agaggtggag     1260

ggcacctcct tcctgacagg catcatctcc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  44
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence (With Padua), Gamma 22 Padua

<400>  44
atgcagaggg tcaacatgat catggcagag tcccctgggc tcatcaccat ctgcctcctg       60

gggtacctgc tcagtgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caactctggg aaactggagg agtttgtcca ggggaacctg      180

gagagggagt gcatggagga gaagtgctcc tttgaggagg ccagggaggt ctttgagaac      240

acagagagga ccactgagtt ctggaagcag tatgtggatg gggaccagtg tgagtccaac      300

ccctgcctca atgggggcag ctgcaaggat gacatcaact cctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgcagctg cactgagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagccagctg tgcccttccc ctgtggcaga      540

gtctcagtgt cccagacctc caagctgacc agagctgaga cagtgttccc agatgtggac      600

tatgtgaact ccacagaggc tgagaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagggt ggtgggagga gaagatgcca agcctgggca gttcccctgg      720

caggtggtgc tcaatggcaa agtggatgcc ttctgtggag gctccattgt caatgagaag      780

tggattgtca cagctgccca ctgtgtggag acaggggtca agatcacagt ggtggcaggg      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggacaagc ccctggtgct gaactcctat gtgaccccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct gggtatgtct caggctgggg cagagtgttc     1080

cacaggggca gaagtgcctc agtgctgcag tacctcaggg tgcccctggt ggacagggcc     1140

acttgcctcc tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc agggttccat     1200

gaggggggca gggactcctg ccagggggac tctgggggcc cccatgtcac agaggtggag     1260

ggcaccagtt tcctcacagg gatcatctcc tggggtgagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccaggtat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  45
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence (With Padua), Gamma 3 Padua

<400>  45
atgcagaggg tcaacatgat catggctgag agccctggcc tcatcaccat ctgcctgctg       60

ggctacctgc tgtcagctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagaggta caacagtggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga caacagagtt ctggaagcag tatgttgatg gtgaccagtg tgagagcaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctt gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa cagtgctgac aacaaggtgg tgtgcagctg cacagagggc      480

tacaggctgg ctgagaacca gaagagctgt gagcctgctg tgcccttccc ctgtggcagg      540

gtgtctgtga gccagacaag caagctgacc agggctgaga cagtgttccc tgatgttgac      600

tatgtcaaca gcacagaggc tgagaccatc ctggacaaca tcacacagtc aacacagagc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggttgatgcc ttctgtgggg gcagcattgt caatgagaag      780

tggattgtga cagctgccca ctgtgttgag acaggggtca agatcacagt ggtggctggt      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtcat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacatagc cctgctggag      960

cttgacaagc ccctggtgct caacagctat gtgaccccca tctgtatagc caacaaggag     1020

tacaccaaca tcttcctcaa gtttggctca ggctatgtgt caggctgggg cagggtgttc     1080

cacaggggca ggtcagcctc tgtgctgcag tacctgaggg tgcccctggt tgacagggcc     1140

acctgcctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggacagctg ccagggtgac agtgggggcc ctcatgtgac agaggttgag     1260

ggcaccagct tcctgacagg catcatcagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcaggtat gtcaactgga tcaaggagaa gaccaagctg     1380

acatga                                                                1386


<210>  46
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence (With Padua), Gamma 87 Padua

<400>  46
atgcagagag tgaacatgat catggctgag tcacctggac tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtc ttcctggatc atgagaatgc caacaagatc      120

ctgaacagac ctaagaggta caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagagagt gcatggagga gaagtgcagc tttgaggagg ccagagaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gtgatcagtg tgagagcaac      300

ccctgcctga atggaggcag ctgcaaggat gatatcaact cctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa cagtgctgat aacaaggtgg tgtgcagctg cacagagggc      480

tacagactgg ctgagaacca gaagagctgt gagccagctg tgcccttccc ctgtggcaga      540

gtgtcagtgt cacagaccag caagctgacc agagctgaga cagtcttccc tgatgtggac      600

tatgtgaaca gcacagaggc tgagaccatc ctggataaca tcacccagtc cacccagtca      660

ttcaatgact tcaccagagt ggtgggagga gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgca ttctgtggag gcagcattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggtgtga agatcacagt ggtggctgga      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgatattgc actgctggag      960

ctggataagc cactggtgct gaacagctat gtgacaccta tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggcagt ggctatgtgt caggctgggg cagagtgttc     1080

cacagaggca gatcagcctc tgtgctgcag tacctgagag tgccactggt ggatagagcc     1140

acctgcctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagatagctg ccagggtgac agtggtggcc ctcatgtgac agaggtggag     1260

ggcacctcct tcctgactgg catcatctcc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gagcagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acatga                                                                1386


<210>  47
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence (With Padua), Gamma 2 Padua

<400>  47
atgcagagag tgaacatgat catggctgag agccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggatc atgagaatgc caacaagatc      120

ctgaacagac ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagagagt gcatggagga gaagtgctcc tttgaggagg ccagagaggt gtttgagaac      240

acagagagaa ccacagagtt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccttgcctga atggaggctc ctgcaaggat gatatcaact cctatgagtg ctggtgccct      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgat aacaaggtgg tgtgctcctg cacagagggc      480

tacagactgg ctgagaacca gaagtcctgt gagcctgctg tgcccttccc ttgtggcaga      540

gtgtctgtgt cccagacctc caagctgacc agagctgaga cagtgttccc tgatgtggat      600

tatgtgaact ccacagaggc tgagaccatc ctggataaca tcacccagtc cacccagtcc      660

ttcaatgatt tcaccagagt ggtgggagga gaggatgcca agcctggcca gttcccttgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggag gctccattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggagtga agatcacagt ggtggctgga      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga gaaatgtgat cagaatcatc      900

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgatattgc cctgctggag      960

ctggataagc ctctggtgct gaactcctat gtgacaccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtgttc     1080

cacagaggca gatctgcctc tgtgctgcag tacctgagag tgcctctggt ggatagagcc     1140

acctgcctgc tgtccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagattcctg ccagggagat tctggaggcc ctcatgtgac agaggtggag     1260

ggcacctcct tcctgacagg catcatctcc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  48
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence (With Padua), Beta 82 Padua

<400>  48
atgcagaggg tgaacatgat catggctgag agccctgggc tgatcaccat ctgcctgctg       60

gggtacctgc tgagtgctga gtgcactgtg ttcctggacc atgagaatgc caacaagatc      120

ctcaacaggc ccaagaggta caacagtggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgcagc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gggaccagtg tgagtccaac      300

ccctgcctga atgggggcag ctgcaaggat gacatcaaca gctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa cagtgctgac aacaaggtgg tgtgcagctg cactgagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagcctgcag tgcccttccc ctgtggcagg      540

gtgtctgtgt cccagaccag caagctcacc agggctgaga ctgtgttccc tgatgtggac      600

tatgtcaaca gcacagaggc tgagaccatc ctggacaaca tcacccagag cacccagagc      660

ttcaatgact tcaccagggt ggtggggggg gaggatgcca agccagggca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtgggg gcagcattgt caatgagaag      780

tggattgtca cagcagccca ctgtgtggag actggggtga agatcacagt ggtggctggg      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtcat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtcaccccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggcagt ggctatgtca gtggctgggg cagggtgttc     1080

cacaggggca ggtctgccag tgtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctgc tgtccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gaggggggca gggacagctg ccagggggac tctgggggcc cccatgtcac tgaggtggag     1260

ggcaccagct tcctgacagg catcatcagc tggggggagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt cagcaggtat gtgaactgga tcaaggagaa gaccaagctc     1380

acctga                                                                1386


<210>  49
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence (With Padua), Beta 81 Padua

<400>  49
atgcagaggg tgaacatgat catggctgag tcccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggacc atgagaatgc caacaagatc      120

ctgaacaggc ccaagaggta caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagggagt gcatggagga gaagtgctcc tttgaggagg ccagggaggt gtttgagaac      240

acagagagga ccacagagtt ctggaagcag tatgtggatg gagaccagtg tgagtccaac      300

ccttgcctga atggaggctc ctgcaaggat gacatcaact cctatgagtg ctggtgcccc      360

tttggctttg agggcaagaa ctgtgagctg gatgccacct gcaacatcaa gaatggcagg      420

tgtgagcagt tctgcaagaa ctctgctgac aacaaggtgg tgtgctcctg cacagagggc      480

tacaggctgg ctgagaacca gaagtcctgt gagccagctg tgcccttccc ttgtggcagg      540

gtgtctgtgt cccagacctc caagctgacc agggctgaga cagtgttccc tgatgtggac      600

tatgtgaact ccacagaggc tgagaccatc ctggacaaca tcacccagtc cacccagtcc      660

ttcaatgact tcaccagggt ggtgggaggt gaggatgcca agcctggcca gttcccttgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggag gctccattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggagtga agatcacagt ggtggctggt      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga ggaatgtgat caggatcatc      900

ccccaccaca actacaatgc tgccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaactcctat gtgaccccca tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt caggatgggg cagggtgttc     1080

cacaggggca ggtctgcctc tgtgctgcag tacctgaggg tgcccctggt ggacagggcc     1140

acctgcctgc tgtccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gggactcctg ccagggtgac tcaggaggcc cccatgtgac agaggtggag     1260

ggcacctcct tcctgacagg catcatcagc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccaggtat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  50
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence (With Padua), Beta 23 Padua

<400>  50
atgcagagag tcaacatgat catggcagag tcacctggac tgatcaccat ctgcctgctg       60

ggctacctgc tcagtgcaga gtgcacagtc ttcctggacc atgagaatgc caacaagatc      120

ctgaacagac ccaagaggta caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagagagt gcatggagga gaagtgctcc tttgaggagg ccagagaggt ctttgagaac      240

actgagagga ccactgagtt ctggaagcag tatgtggatg gtgatcagtg tgagtccaac      300

ccatgcctga atggaggctc ctgcaaggat gacatcaact cctatgagtg ctggtgccca      360

tttggctttg agggcaagaa ctgtgagctg gatgcaacat gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa cagtgcagac aacaaggtgg tgtgctcctg cacagagggc      480

tacagactgg ctgagaacca gaagtcatgt gagcctgctg tgcccttccc ctgtggcaga      540

gtgagtgtgt cccagaccag caagctgacc agagctgaga cagtcttccc tgatgtggac      600

tatgtgaact ccacagaggc agagaccatc ctggacaaca tcacacagtc cacacagtcc      660

ttcaatgact tcaccagagt ggttggtggt gaggatgcca agcctggaca gttcccctgg      720

caggtggtgc tcaatggcaa ggtggatgcc ttctgtggag gctccattgt caatgagaag      780

tggattgtca cagctgccca ctgtgtggag actggtgtga agatcactgt ggtggctggt      840

gagcacaaca ttgaggagac agagcacact gagcagaaga ggaatgtcat caggatcatc      900

ccacaccaca actacaatgc agccatcaac aagtacaacc atgacattgc cctgctggag      960

ctggatgagc ccctggtgct gaacagctat gtgaccccca tctgcatagc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtcttc     1080

cacagaggca gatctgcctc tgtgctgcag tacctgagag tgcctctggt ggacagagca     1140

acctgcctgc tgagcaccaa gttcaccatc tacaacaaca tgttctgtgc aggcttccat     1200

gagggaggca gagactcctg ccagggagac tctggtgggc cacatgtgac agaggtggag     1260

ggcacatcct tcctgacagg catcatctcc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccaggtat gtcaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  51
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FIX Optimized Sequence (With Padua), Beta 39 Padua

<400>  51
atgcagagag tgaacatgat catggctgag tcccctggcc tgatcaccat ctgcctgctg       60

ggctacctgc tgtctgctga gtgcacagtg ttcctggatc atgagaatgc caacaagatc      120

ctgaacagac ccaagagata caactctggc aagctggagg agtttgtgca gggcaacctg      180

gagagagagt gcatggagga gaagtgctcc tttgaggagg ccagagaggt gtttgagaac      240

acagagagaa ccacagagtt ctggaagcag tatgtggatg gagatcagtg tgagtccaac      300

ccttgcctga atggaggctc ctgcaaggat gatatcaact cctatgagtg ctggtgccca      360

tttggctttg agggcaagaa ttgtgagctg gatgccacct gcaacatcaa gaatggcaga      420

tgtgagcagt tctgcaagaa ctctgctgat aacaaggtgg tgtgctcctg cacagagggc      480

tacagactgg ctgagaacca gaagtcctgt gagcctgctg tgcctttccc ttgtggcaga      540

gtgtctgtgt cccagacctc caagctgacc agagctgaga cagtgttccc tgatgtggat      600

tatgtgaact ccacagaggc tgagaccatc ctggataaca tcacccagtc cacccagtcc      660

ttcaatgatt tcaccagagt ggtgggagga gaggatgcca agcctggcca gttcccctgg      720

caggtggtgc tgaatggcaa ggtggatgcc ttctgtggag gctccattgt gaatgagaag      780

tggattgtga cagctgccca ctgtgtggag acaggagtga agatcacagt ggtggctgga      840

gagcacaaca ttgaggagac agagcacaca gagcagaaga gaaatgtgat cagaatcatc      900

cctcaccaca actacaatgc tgccatcaac aagtacaacc atgatattgc cctgctggag      960

ctggatgagc ccctggtgct gaactcctat gtgaccccta tctgcattgc caacaaggag     1020

tacaccaaca tcttcctgaa gtttggctct ggctatgtgt ctggctgggg cagagtgttc     1080

cacagaggca gatctgcctc tgtgctgcag tacctgagag tgcctctggt ggatagagcc     1140

acctgcctgc tgtccaccaa gttcaccatc tacaacaaca tgttctgtgc tggcttccat     1200

gagggaggca gagattcctg ccagggagat tctggaggcc ctcatgtgac agaggtggag     1260

ggcacctcct tcctgacagg catcatctcc tggggagagg agtgtgccat gaagggcaag     1320

tatggcatct acaccaaggt gtccagatat gtgaactgga tcaaggagaa gaccaagctg     1380

acctga                                                                1386


<210>  52
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Alpha (no Padua)

<400>  52

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asn Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Lys Gly Arg Ser Ala Ser Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  53
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Beta (no Padua)

<400>  53

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asn Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Arg Gly Arg Ser Ala Ser Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  54
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Delta (no Padua)

<400>  54

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Lys Pro Leu Thr Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asn Arg Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Arg Gly Arg Ser Ala Ser Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  55
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma (no Padua)

<400>  55

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Lys Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asn Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Arg Gly Arg Ser Ala Ser Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Arg 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  56
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Gamma (with Padua)

<400>  56

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Lys Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asn Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Arg Gly Arg Ser Ala Ser Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


<210>  57
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Beta (with Padua)

<400>  57

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys Thr Val Phe Leu 
            20                  25                  30          


Asp His Glu Asn Ala Asn Lys Ile Leu Asn Arg Pro Lys Arg Tyr Asn 
        35                  40                  45              


Ser Gly Lys Leu Glu Glu Phe Val Gln Gly Asn Leu Glu Arg Glu Cys 
    50                  55                  60                  


Met Glu Glu Lys Cys Ser Phe Glu Glu Ala Arg Glu Val Phe Glu Asn 
65                  70                  75                  80  


Thr Glu Arg Thr Thr Glu Phe Trp Lys Gln Tyr Val Asp Gly Asp Gln 
                85                  90                  95      


Cys Glu Ser Asn Pro Cys Leu Asn Gly Gly Ser Cys Lys Asp Asp Ile 
            100                 105                 110         


Asn Ser Tyr Glu Cys Trp Cys Pro Phe Gly Phe Glu Gly Lys Asn Cys 
        115                 120                 125             


Glu Leu Asp Ala Thr Cys Asn Ile Lys Asn Gly Arg Cys Glu Gln Phe 
    130                 135                 140                 


Cys Lys Asn Ser Ala Asp Asn Lys Val Val Cys Ser Cys Thr Glu Gly 
145                 150                 155                 160 


Tyr Arg Leu Ala Glu Asn Gln Lys Ser Cys Glu Pro Ala Val Pro Phe 
                165                 170                 175     


Pro Cys Gly Arg Val Ser Val Ser Gln Thr Ser Lys Leu Thr Arg Ala 
            180                 185                 190         


Glu Thr Val Phe Pro Asp Val Asp Tyr Val Asn Ser Thr Glu Ala Glu 
        195                 200                 205             


Thr Ile Leu Asp Asn Ile Thr Gln Ser Thr Gln Ser Phe Asn Asp Phe 
    210                 215                 220                 


Thr Arg Val Val Gly Gly Glu Asp Ala Lys Pro Gly Gln Phe Pro Trp 
225                 230                 235                 240 


Gln Val Val Leu Asn Gly Lys Val Asp Ala Phe Cys Gly Gly Ser Ile 
                245                 250                 255     


Val Asn Glu Lys Trp Ile Val Thr Ala Ala His Cys Val Glu Thr Gly 
            260                 265                 270         


Val Lys Ile Thr Val Val Ala Gly Glu His Asn Ile Glu Glu Thr Glu 
        275                 280                 285             


His Thr Glu Gln Lys Arg Asn Val Ile Arg Ile Ile Pro His His Asn 
    290                 295                 300                 


Tyr Asn Ala Ala Ile Asn Lys Tyr Asn His Asp Ile Ala Leu Leu Glu 
305                 310                 315                 320 


Leu Asp Glu Pro Leu Val Leu Asn Ser Tyr Val Thr Pro Ile Cys Ile 
                325                 330                 335     


Ala Asn Lys Glu Tyr Thr Asn Ile Phe Leu Lys Phe Gly Ser Gly Tyr 
            340                 345                 350         


Val Ser Gly Trp Gly Arg Val Phe His Arg Gly Arg Ser Ala Ser Val 
        355                 360                 365             


Leu Gln Tyr Leu Arg Val Pro Leu Val Asp Arg Ala Thr Cys Leu Leu 
    370                 375                 380                 


Ser Thr Lys Phe Thr Ile Tyr Asn Asn Met Phe Cys Ala Gly Phe His 
385                 390                 395                 400 


Glu Gly Gly Arg Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro His Val 
                405                 410                 415     


Thr Glu Val Glu Gly Thr Ser Phe Leu Thr Gly Ile Ile Ser Trp Gly 
            420                 425                 430         


Glu Glu Cys Ala Met Lys Gly Lys Tyr Gly Ile Tyr Thr Lys Val Ser 
        435                 440                 445             


Arg Tyr Val Asn Trp Ile Lys Glu Lys Thr Lys Leu Thr 
    450                 455                 460     


