                         SEQUENCE LISTING

<110>  ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
 
<120>  METHODS OF TREATING TUMORS AND CANCERS HAVING DYSREGULATED WNT 
       SIGNALING PATHWAYS

<130>  147535.000931

<140>  PCT/US2021/057746
<141>  2021-11-02

<150>  63/108,728
<151>  2020-11-02

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  2
<211>  2843
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Ala Ser Tyr Asp Gln Leu Leu Lys Gln Val Glu Ala Leu 
1               5                   10                  15      


Lys Met Glu Asn Ser Asn Leu Arg Gln Glu Leu Glu Asp Asn Ser Asn 
            20                  25                  30          


His Leu Thr Lys Leu Glu Thr Glu Ala Ser Asn Met Lys Glu Val Leu 
        35                  40                  45              


Lys Gln Leu Gln Gly Ser Ile Glu Asp Glu Ala Met Ala Ser Ser Gly 
    50                  55                  60                  


Gln Ile Asp Leu Leu Glu Arg Leu Lys Glu Leu Asn Leu Asp Ser Ser 
65                  70                  75                  80  


Asn Phe Pro Gly Val Lys Leu Arg Ser Lys Met Ser Leu Arg Ser Tyr 
                85                  90                  95      


Gly Ser Arg Glu Gly Ser Val Ser Ser Arg Ser Gly Glu Cys Ser Pro 
            100                 105                 110         


Val Pro Met Gly Ser Phe Pro Arg Arg Gly Phe Val Asn Gly Ser Arg 
        115                 120                 125             


Glu Ser Thr Gly Tyr Leu Glu Glu Leu Glu Lys Glu Arg Ser Leu Leu 
    130                 135                 140                 


Leu Ala Asp Leu Asp Lys Glu Glu Lys Glu Lys Asp Trp Tyr Tyr Ala 
145                 150                 155                 160 


Gln Leu Gln Asn Leu Thr Lys Arg Ile Asp Ser Leu Pro Leu Thr Glu 
                165                 170                 175     


Asn Phe Ser Leu Gln Thr Asp Met Thr Arg Arg Gln Leu Glu Tyr Glu 
            180                 185                 190         


Ala Arg Gln Ile Arg Val Ala Met Glu Glu Gln Leu Gly Thr Cys Gln 
        195                 200                 205             


Asp Met Glu Lys Arg Ala Gln Arg Arg Ile Ala Arg Ile Gln Gln Ile 
    210                 215                 220                 


Glu Lys Asp Ile Leu Arg Ile Arg Gln Leu Leu Gln Ser Gln Ala Thr 
225                 230                 235                 240 


Glu Ala Glu Arg Ser Ser Gln Asn Lys His Glu Thr Gly Ser His Asp 
                245                 250                 255     


Ala Glu Arg Gln Asn Glu Gly Gln Gly Val Gly Glu Ile Asn Met Ala 
            260                 265                 270         


Thr Ser Gly Asn Gly Gln Gly Ser Thr Thr Arg Met Asp His Glu Thr 
        275                 280                 285             


Ala Ser Val Leu Ser Ser Ser Ser Thr His Ser Ala Pro Arg Arg Leu 
    290                 295                 300                 


Thr Ser His Leu Gly Thr Lys Val Glu Met Val Tyr Ser Leu Leu Ser 
305                 310                 315                 320 


Met Leu Gly Thr His Asp Lys Asp Asp Met Ser Arg Thr Leu Leu Ala 
                325                 330                 335     


Met Ser Ser Ser Gln Asp Ser Cys Ile Ser Met Arg Gln Ser Gly Cys 
            340                 345                 350         


Leu Pro Leu Leu Ile Gln Leu Leu His Gly Asn Asp Lys Asp Ser Val 
        355                 360                 365             


Leu Leu Gly Asn Ser Arg Gly Ser Lys Glu Ala Arg Ala Arg Ala Ser 
    370                 375                 380                 


Ala Ala Leu His Asn Ile Ile His Ser Gln Pro Asp Asp Lys Arg Gly 
385                 390                 395                 400 


Arg Arg Glu Ile Arg Val Leu His Leu Leu Glu Gln Ile Arg Ala Tyr 
                405                 410                 415     


Cys Glu Thr Cys Trp Glu Trp Gln Glu Ala His Glu Pro Gly Met Asp 
            420                 425                 430         


Gln Asp Lys Asn Pro Met Pro Ala Pro Val Glu His Gln Ile Cys Pro 
        435                 440                 445             


Ala Val Cys Val Leu Met Lys Leu Ser Phe Asp Glu Glu His Arg His 
    450                 455                 460                 


Ala Met Asn Glu Leu Gly Gly Leu Gln Ala Ile Ala Glu Leu Leu Gln 
465                 470                 475                 480 


Val Asp Cys Glu Met Tyr Gly Leu Thr Asn Asp His Tyr Ser Ile Thr 
                485                 490                 495     


Leu Arg Arg Tyr Ala Gly Met Ala Leu Thr Asn Leu Thr Phe Gly Asp 
            500                 505                 510         


Val Ala Asn Lys Ala Thr Leu Cys Ser Met Lys Gly Cys Met Arg Ala 
        515                 520                 525             


Leu Val Ala Gln Leu Lys Ser Glu Ser Glu Asp Leu Gln Gln Val Ile 
    530                 535                 540                 


Ala Ser Val Leu Arg Asn Leu Ser Trp Arg Ala Asp Val Asn Ser Lys 
545                 550                 555                 560 


Lys Thr Leu Arg Glu Val Gly Ser Val Lys Ala Leu Met Glu Cys Ala 
                565                 570                 575     


Leu Glu Val Lys Lys Glu Ser Thr Leu Lys Ser Val Leu Ser Ala Leu 
            580                 585                 590         


Trp Asn Leu Ser Ala His Cys Thr Glu Asn Lys Ala Asp Ile Cys Ala 
        595                 600                 605             


Val Asp Gly Ala Leu Ala Phe Leu Val Gly Thr Leu Thr Tyr Arg Ser 
    610                 615                 620                 


Gln Thr Asn Thr Leu Ala Ile Ile Glu Ser Gly Gly Gly Ile Leu Arg 
625                 630                 635                 640 


Asn Val Ser Ser Leu Ile Ala Thr Asn Glu Asp His Arg Gln Ile Leu 
                645                 650                 655     


Arg Glu Asn Asn Cys Leu Gln Thr Leu Leu Gln His Leu Lys Ser His 
            660                 665                 670         


Ser Leu Thr Ile Val Ser Asn Ala Cys Gly Thr Leu Trp Asn Leu Ser 
        675                 680                 685             


Ala Arg Asn Pro Lys Asp Gln Glu Ala Leu Trp Asp Met Gly Ala Val 
    690                 695                 700                 


Ser Met Leu Lys Asn Leu Ile His Ser Lys His Lys Met Ile Ala Met 
705                 710                 715                 720 


Gly Ser Ala Ala Ala Leu Arg Asn Leu Met Ala Asn Arg Pro Ala Lys 
                725                 730                 735     


Tyr Lys Asp Ala Asn Ile Met Ser Pro Gly Ser Ser Leu Pro Ser Leu 
            740                 745                 750         


His Val Arg Lys Gln Lys Ala Leu Glu Ala Glu Leu Asp Ala Gln His 
        755                 760                 765             


Leu Ser Glu Thr Phe Asp Asn Ile Asp Asn Leu Ser Pro Lys Ala Ser 
    770                 775                 780                 


His Arg Ser Lys Gln Arg His Lys Gln Ser Leu Tyr Gly Asp Tyr Val 
785                 790                 795                 800 


Phe Asp Thr Asn Arg His Asp Asp Asn Arg Ser Asp Asn Phe Asn Thr 
                805                 810                 815     


Gly Asn Met Thr Val Leu Ser Pro Tyr Leu Asn Thr Thr Val Leu Pro 
            820                 825                 830         


Ser Ser Ser Ser Ser Arg Gly Ser Leu Asp Ser Ser Arg Ser Glu Lys 
        835                 840                 845             


Asp Arg Ser Leu Glu Arg Glu Arg Gly Ile Gly Leu Gly Asn Tyr His 
    850                 855                 860                 


Pro Ala Thr Glu Asn Pro Gly Thr Ser Ser Lys Arg Gly Leu Gln Ile 
865                 870                 875                 880 


Ser Thr Thr Ala Ala Gln Ile Ala Lys Val Met Glu Glu Val Ser Ala 
                885                 890                 895     


Ile His Thr Ser Gln Glu Asp Arg Ser Ser Gly Ser Thr Thr Glu Leu 
            900                 905                 910         


His Cys Val Thr Asp Glu Arg Asn Ala Leu Arg Arg Ser Ser Ala Ala 
        915                 920                 925             


His Thr His Ser Asn Thr Tyr Asn Phe Thr Lys Ser Glu Asn Ser Asn 
    930                 935                 940                 


Arg Thr Cys Ser Met Pro Tyr Ala Lys Leu Glu Tyr Lys Arg Ser Ser 
945                 950                 955                 960 


Asn Asp Ser Leu Asn Ser Val Ser Ser Ser Asp Gly Tyr Gly Lys Arg 
                965                 970                 975     


Gly Gln Met Lys Pro Ser Ile Glu Ser Tyr Ser Glu Asp Asp Glu Ser 
            980                 985                 990         


Lys Phe Cys Ser Tyr Gly Gln Tyr  Pro Ala Asp Leu Ala  His Lys Ile 
        995                 1000                 1005             


His Ser  Ala Asn His Met Asp  Asp Asn Asp Gly Glu  Leu Asp Thr 
    1010                 1015                 1020             


Pro Ile  Asn Tyr Ser Leu Lys  Tyr Ser Asp Glu Gln  Leu Asn Ser 
    1025                 1030                 1035             


Gly Arg  Gln Ser Pro Ser Gln  Asn Glu Arg Trp Ala  Arg Pro Lys 
    1040                 1045                 1050             


His Ile  Ile Glu Asp Glu Ile  Lys Gln Ser Glu Gln  Arg Gln Ser 
    1055                 1060                 1065             


Arg Asn  Gln Ser Thr Thr Tyr  Pro Val Tyr Thr Glu  Ser Thr Asp 
    1070                 1075                 1080             


Asp Lys  His Leu Lys Phe Gln  Pro His Phe Gly Gln  Gln Glu Cys 
    1085                 1090                 1095             


Val Ser  Pro Tyr Arg Ser Arg  Gly Ala Asn Gly Ser  Glu Thr Asn 
    1100                 1105                 1110             


Arg Val  Gly Ser Asn His Gly  Ile Asn Gln Asn Val  Ser Gln Ser 
    1115                 1120                 1125             


Leu Cys  Gln Glu Asp Asp Tyr  Glu Asp Asp Lys Pro  Thr Asn Tyr 
    1130                 1135                 1140             


Ser Glu  Arg Tyr Ser Glu Glu  Glu Gln His Glu Glu  Glu Glu Arg 
    1145                 1150                 1155             


Pro Thr  Asn Tyr Ser Ile Lys  Tyr Asn Glu Glu Lys  Arg His Val 
    1160                 1165                 1170             


Asp Gln  Pro Ile Asp Tyr Ser  Leu Lys Tyr Ala Thr  Asp Ile Pro 
    1175                 1180                 1185             


Ser Ser  Gln Lys Gln Ser Phe  Ser Phe Ser Lys Ser  Ser Ser Gly 
    1190                 1195                 1200             


Gln Ser  Ser Lys Thr Glu His  Met Ser Ser Ser Ser  Glu Asn Thr 
    1205                 1210                 1215             


Ser Thr  Pro Ser Ser Asn Ala  Lys Arg Gln Asn Gln  Leu His Pro 
    1220                 1225                 1230             


Ser Ser  Ala Gln Ser Arg Ser  Gly Gln Pro Gln Lys  Ala Ala Thr 
    1235                 1240                 1245             


Cys Lys  Val Ser Ser Ile Asn  Gln Glu Thr Ile Gln  Thr Tyr Cys 
    1250                 1255                 1260             


Val Glu  Asp Thr Pro Ile Cys  Phe Ser Arg Cys Ser  Ser Leu Ser 
    1265                 1270                 1275             


Ser Leu  Ser Ser Ala Glu Asp  Glu Ile Gly Cys Asn  Gln Thr Thr 
    1280                 1285                 1290             


Gln Glu  Ala Asp Ser Ala Asn  Thr Leu Gln Ile Ala  Glu Ile Lys 
    1295                 1300                 1305             


Glu Lys  Ile Gly Thr Arg Ser  Ala Glu Asp Pro Val  Ser Glu Val 
    1310                 1315                 1320             


Pro Ala  Val Ser Gln His Pro  Arg Thr Lys Ser Ser  Arg Leu Gln 
    1325                 1330                 1335             


Gly Ser  Ser Leu Ser Ser Glu  Ser Ala Arg His Lys  Ala Val Glu 
    1340                 1345                 1350             


Phe Ser  Ser Gly Ala Lys Ser  Pro Ser Lys Ser Gly  Ala Gln Thr 
    1355                 1360                 1365             


Pro Lys  Ser Pro Pro Glu His  Tyr Val Gln Glu Thr  Pro Leu Met 
    1370                 1375                 1380             


Phe Ser  Arg Cys Thr Ser Val  Ser Ser Leu Asp Ser  Phe Glu Ser 
    1385                 1390                 1395             


Arg Ser  Ile Ala Ser Ser Val  Gln Ser Glu Pro Cys  Ser Gly Met 
    1400                 1405                 1410             


Val Ser  Gly Ile Ile Ser Pro  Ser Asp Leu Pro Asp  Ser Pro Gly 
    1415                 1420                 1425             


Gln Thr  Met Pro Pro Ser Arg  Ser Lys Thr Pro Pro  Pro Pro Pro 
    1430                 1435                 1440             


Gln Thr  Ala Gln Thr Lys Arg  Glu Val Pro Lys Asn  Lys Ala Pro 
    1445                 1450                 1455             


Thr Ala  Glu Lys Arg Glu Ser  Gly Pro Lys Gln Ala  Ala Val Asn 
    1460                 1465                 1470             


Ala Ala  Val Gln Arg Val Gln  Val Leu Pro Asp Ala  Asp Thr Leu 
    1475                 1480                 1485             


Leu His  Phe Ala Thr Glu Ser  Thr Pro Asp Gly Phe  Ser Cys Ser 
    1490                 1495                 1500             


Ser Ser  Leu Ser Ala Leu Ser  Leu Asp Glu Pro Phe  Ile Gln Lys 
    1505                 1510                 1515             


Asp Val  Glu Leu Arg Ile Met  Pro Pro Val Gln Glu  Asn Asp Asn 
    1520                 1525                 1530             


Gly Asn  Glu Thr Glu Ser Glu  Gln Pro Lys Glu Ser  Asn Glu Asn 
    1535                 1540                 1545             


Gln Glu  Lys Glu Ala Glu Lys  Thr Ile Asp Ser Glu  Lys Asp Leu 
    1550                 1555                 1560             


Leu Asp  Asp Ser Asp Asp Asp  Asp Ile Glu Ile Leu  Glu Glu Cys 
    1565                 1570                 1575             


Ile Ile  Ser Ala Met Pro Thr  Lys Ser Ser Arg Lys  Ala Lys Lys 
    1580                 1585                 1590             


Pro Ala  Gln Thr Ala Ser Lys  Leu Pro Pro Pro Val  Ala Arg Lys 
    1595                 1600                 1605             


Pro Ser  Gln Leu Pro Val Tyr  Lys Leu Leu Pro Ser  Gln Asn Arg 
    1610                 1615                 1620             


Leu Gln  Pro Gln Lys His Val  Ser Phe Thr Pro Gly  Asp Asp Met 
    1625                 1630                 1635             


Pro Arg  Val Tyr Cys Val Glu  Gly Thr Pro Ile Asn  Phe Ser Thr 
    1640                 1645                 1650             


Ala Thr  Ser Leu Ser Asp Leu  Thr Ile Glu Ser Pro  Pro Asn Glu 
    1655                 1660                 1665             


Leu Ala  Ala Gly Glu Gly Val  Arg Gly Gly Ala Gln  Ser Gly Glu 
    1670                 1675                 1680             


Phe Glu  Lys Arg Asp Thr Ile  Pro Thr Glu Gly Arg  Ser Thr Asp 
    1685                 1690                 1695             


Glu Ala  Gln Gly Gly Lys Thr  Ser Ser Val Thr Ile  Pro Glu Leu 
    1700                 1705                 1710             


Asp Asp  Asn Lys Ala Glu Glu  Gly Asp Ile Leu Ala  Glu Cys Ile 
    1715                 1720                 1725             


Asn Ser  Ala Met Pro Lys Gly  Lys Ser His Lys Pro  Phe Arg Val 
    1730                 1735                 1740             


Lys Lys  Ile Met Asp Gln Val  Gln Gln Ala Ser Ala  Ser Ser Ser 
    1745                 1750                 1755             


Ala Pro  Asn Lys Asn Gln Leu  Asp Gly Lys Lys Lys  Lys Pro Thr 
    1760                 1765                 1770             


Ser Pro  Val Lys Pro Ile Pro  Gln Asn Thr Glu Tyr  Arg Thr Arg 
    1775                 1780                 1785             


Val Arg  Lys Asn Ala Asp Ser  Lys Asn Asn Leu Asn  Ala Glu Arg 
    1790                 1795                 1800             


Val Phe  Ser Asp Asn Lys Asp  Ser Lys Lys Gln Asn  Leu Lys Asn 
    1805                 1810                 1815             


Asn Ser  Lys Val Phe Asn Asp  Lys Leu Pro Asn Asn  Glu Asp Arg 
    1820                 1825                 1830             


Val Arg  Gly Ser Phe Ala Phe  Asp Ser Pro His His  Tyr Thr Pro 
    1835                 1840                 1845             


Ile Glu  Gly Thr Pro Tyr Cys  Phe Ser Arg Asn Asp  Ser Leu Ser 
    1850                 1855                 1860             


Ser Leu  Asp Phe Asp Asp Asp  Asp Val Asp Leu Ser  Arg Glu Lys 
    1865                 1870                 1875             


Ala Glu  Leu Arg Lys Ala Lys  Glu Asn Lys Glu Ser  Glu Ala Lys 
    1880                 1885                 1890             


Val Thr  Ser His Thr Glu Leu  Thr Ser Asn Gln Gln  Ser Ala Asn 
    1895                 1900                 1905             


Lys Thr  Gln Ala Ile Ala Lys  Gln Pro Ile Asn Arg  Gly Gln Pro 
    1910                 1915                 1920             


Lys Pro  Ile Leu Gln Lys Gln  Ser Thr Phe Pro Gln  Ser Ser Lys 
    1925                 1930                 1935             


Asp Ile  Pro Asp Arg Gly Ala  Ala Thr Asp Glu Lys  Leu Gln Asn 
    1940                 1945                 1950             


Phe Ala  Ile Glu Asn Thr Pro  Val Cys Phe Ser His  Asn Ser Ser 
    1955                 1960                 1965             


Leu Ser  Ser Leu Ser Asp Ile  Asp Gln Glu Asn Asn  Asn Lys Glu 
    1970                 1975                 1980             


Asn Glu  Pro Ile Lys Glu Thr  Glu Pro Pro Asp Ser  Gln Gly Glu 
    1985                 1990                 1995             


Pro Ser  Lys Pro Gln Ala Ser  Gly Tyr Ala Pro Lys  Ser Phe His 
    2000                 2005                 2010             


Val Glu  Asp Thr Pro Val Cys  Phe Ser Arg Asn Ser  Ser Leu Ser 
    2015                 2020                 2025             


Ser Leu  Ser Ile Asp Ser Glu  Asp Asp Leu Leu Gln  Glu Cys Ile 
    2030                 2035                 2040             


Ser Ser  Ala Met Pro Lys Lys  Lys Lys Pro Ser Arg  Leu Lys Gly 
    2045                 2050                 2055             


Asp Asn  Glu Lys His Ser Pro  Arg Asn Met Gly Gly  Ile Leu Gly 
    2060                 2065                 2070             


Glu Asp  Leu Thr Leu Asp Leu  Lys Asp Ile Gln Arg  Pro Asp Ser 
    2075                 2080                 2085             


Glu His  Gly Leu Ser Pro Asp  Ser Glu Asn Phe Asp  Trp Lys Ala 
    2090                 2095                 2100             


Ile Gln  Glu Gly Ala Asn Ser  Ile Val Ser Ser Leu  His Gln Ala 
    2105                 2110                 2115             


Ala Ala  Ala Ala Cys Leu Ser  Arg Gln Ala Ser Ser  Asp Ser Asp 
    2120                 2125                 2130             


Ser Ile  Leu Ser Leu Lys Ser  Gly Ile Ser Leu Gly  Ser Pro Phe 
    2135                 2140                 2145             


His Leu  Thr Pro Asp Gln Glu  Glu Lys Pro Phe Thr  Ser Asn Lys 
    2150                 2155                 2160             


Gly Pro  Arg Ile Leu Lys Pro  Gly Glu Lys Ser Thr  Leu Glu Thr 
    2165                 2170                 2175             


Lys Lys  Ile Glu Ser Glu Ser  Lys Gly Ile Lys Gly  Gly Lys Lys 
    2180                 2185                 2190             


Val Tyr  Lys Ser Leu Ile Thr  Gly Lys Val Arg Ser  Asn Ser Glu 
    2195                 2200                 2205             


Ile Ser  Gly Gln Met Lys Gln  Pro Leu Gln Ala Asn  Met Pro Ser 
    2210                 2215                 2220             


Ile Ser  Arg Gly Arg Thr Met  Ile His Ile Pro Gly  Val Arg Asn 
    2225                 2230                 2235             


Ser Ser  Ser Ser Thr Ser Pro  Val Ser Lys Lys Gly  Pro Pro Leu 
    2240                 2245                 2250             


Lys Thr  Pro Ala Ser Lys Ser  Pro Ser Glu Gly Gln  Thr Ala Thr 
    2255                 2260                 2265             


Thr Ser  Pro Arg Gly Ala Lys  Pro Ser Val Lys Ser  Glu Leu Ser 
    2270                 2275                 2280             


Pro Val  Ala Arg Gln Thr Ser  Gln Ile Gly Gly Ser  Ser Lys Ala 
    2285                 2290                 2295             


Pro Ser  Arg Ser Gly Ser Arg  Asp Ser Thr Pro Ser  Arg Pro Ala 
    2300                 2305                 2310             


Gln Gln  Pro Leu Ser Arg Pro  Ile Gln Ser Pro Gly  Arg Asn Ser 
    2315                 2320                 2325             


Ile Ser  Pro Gly Arg Asn Gly  Ile Ser Pro Pro Asn  Lys Leu Ser 
    2330                 2335                 2340             


Gln Leu  Pro Arg Thr Ser Ser  Pro Ser Thr Ala Ser  Thr Lys Ser 
    2345                 2350                 2355             


Ser Gly  Ser Gly Lys Met Ser  Tyr Thr Ser Pro Gly  Arg Gln Met 
    2360                 2365                 2370             


Ser Gln  Gln Asn Leu Thr Lys  Gln Thr Gly Leu Ser  Lys Asn Ala 
    2375                 2380                 2385             


Ser Ser  Ile Pro Arg Ser Glu  Ser Ala Ser Lys Gly  Leu Asn Gln 
    2390                 2395                 2400             


Met Asn  Asn Gly Asn Gly Ala  Asn Lys Lys Val Glu  Leu Ser Arg 
    2405                 2410                 2415             


Met Ser  Ser Thr Lys Ser Ser  Gly Ser Glu Ser Asp  Arg Ser Glu 
    2420                 2425                 2430             


Arg Pro  Val Leu Val Arg Gln  Ser Thr Phe Ile Lys  Glu Ala Pro 
    2435                 2440                 2445             


Ser Pro  Thr Leu Arg Arg Lys  Leu Glu Glu Ser Ala  Ser Phe Glu 
    2450                 2455                 2460             


Ser Leu  Ser Pro Ser Ser Arg  Pro Ala Ser Pro Thr  Arg Ser Gln 
    2465                 2470                 2475             


Ala Gln  Thr Pro Val Leu Ser  Pro Ser Leu Pro Asp  Met Ser Leu 
    2480                 2485                 2490             


Ser Thr  His Ser Ser Val Gln  Ala Gly Gly Trp Arg  Lys Leu Pro 
    2495                 2500                 2505             


Pro Asn  Leu Ser Pro Thr Ile  Glu Tyr Asn Asp Gly  Arg Pro Ala 
    2510                 2515                 2520             


Lys Arg  His Asp Ile Ala Arg  Ser His Ser Glu Ser  Pro Ser Arg 
    2525                 2530                 2535             


Leu Pro  Ile Asn Arg Ser Gly  Thr Trp Lys Arg Glu  His Ser Lys 
    2540                 2545                 2550             


His Ser  Ser Ser Leu Pro Arg  Val Ser Thr Trp Arg  Arg Thr Gly 
    2555                 2560                 2565             


Ser Ser  Ser Ser Ile Leu Ser  Ala Ser Ser Glu Ser  Ser Glu Lys 
    2570                 2575                 2580             


Ala Lys  Ser Glu Asp Glu Lys  His Val Asn Ser Ile  Ser Gly Thr 
    2585                 2590                 2595             


Lys Gln  Ser Lys Glu Asn Gln  Val Ser Ala Lys Gly  Thr Trp Arg 
    2600                 2605                 2610             


Lys Ile  Lys Glu Asn Glu Phe  Ser Pro Thr Asn Ser  Thr Ser Gln 
    2615                 2620                 2625             


Thr Val  Ser Ser Gly Ala Thr  Asn Gly Ala Glu Ser  Lys Thr Leu 
    2630                 2635                 2640             


Ile Tyr  Gln Met Ala Pro Ala  Val Ser Lys Thr Glu  Asp Val Trp 
    2645                 2650                 2655             


Val Arg  Ile Glu Asp Cys Pro  Ile Asn Asn Pro Arg  Ser Gly Arg 
    2660                 2665                 2670             


Ser Pro  Thr Gly Asn Thr Pro  Pro Val Ile Asp Ser  Val Ser Glu 
    2675                 2680                 2685             


Lys Ala  Asn Pro Asn Ile Lys  Asp Ser Lys Asp Asn  Gln Ala Lys 
    2690                 2695                 2700             


Gln Asn  Val Gly Asn Gly Ser  Val Pro Met Arg Thr  Val Gly Leu 
    2705                 2710                 2715             


Glu Asn  Arg Leu Asn Ser Phe  Ile Gln Val Asp Ala  Pro Asp Gln 
    2720                 2725                 2730             


Lys Gly  Thr Glu Ile Lys Pro  Gly Gln Asn Asn Pro  Val Pro Val 
    2735                 2740                 2745             


Ser Glu  Thr Asn Glu Ser Ser  Ile Val Glu Arg Thr  Pro Phe Ser 
    2750                 2755                 2760             


Ser Ser  Ser Ser Ser Lys His  Ser Ser Pro Ser Gly  Thr Val Ala 
    2765                 2770                 2775             


Ala Arg  Val Thr Pro Phe Asn  Tyr Asn Pro Ser Pro  Arg Lys Ser 
    2780                 2785                 2790             


Ser Ala  Asp Ser Thr Ser Ala  Arg Pro Ser Gln Ile  Pro Thr Pro 
    2795                 2800                 2805             


Val Asn  Asn Asn Thr Lys Lys  Arg Asp Ser Lys Thr  Asp Ser Thr 
    2810                 2815                 2820             


Glu Ser  Ser Gly Thr Gln Ser  Pro Lys Arg His Ser  Gly Ser Tyr 
    2825                 2830                 2835             


Leu Val  Thr Ser Val 
    2840             


<210>  3
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Ile Gln Glu Gln Gly Phe Pro Leu Asp Leu Gly Ala Ser Phe 
1               5                   10                  15      


Thr Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu Leu 
            20                  25                  30          


Val Ser Thr Asp Pro Arg Pro Ala Ser Tyr Ser Phe Cys Ser Gly Lys 
        35                  40                  45              


Gly Val Gly Ile Lys Gly Glu Thr Ser Thr Ala Thr Pro Arg Arg Ser 
    50                  55                  60                  


Asp Leu Asp Leu Gly Tyr Glu Pro Glu Gly Ser Ala Ser Pro Thr Pro 
65                  70                  75                  80  


Pro Tyr Leu Lys Trp Ala Glu Ser Leu His Ser Leu Leu Asp Asp Gln 
                85                  90                  95      


Asp Gly Ile Ser Leu Phe Arg Thr Phe Leu Lys Gln Glu Gly Cys Ala 
            100                 105                 110         


Asp Leu Leu Asp Phe Trp Phe Ala Cys Thr Gly Phe Arg Lys Leu Glu 
        115                 120                 125             


Pro Cys Asp Ser Asn Glu Glu Lys Arg Leu Lys Leu Ala Arg Ala Ile 
    130                 135                 140                 


Tyr Arg Lys Tyr Ile Leu Asp Asn Asn Gly Ile Val Ser Arg Gln Thr 
145                 150                 155                 160 


Lys Pro Ala Thr Lys Ser Phe Ile Lys Gly Cys Ile Met Lys Gln Leu 
                165                 170                 175     


Ile Asp Pro Ala Met Phe Asp Gln Ala Gln Thr Glu Ile Gln Ala Thr 
            180                 185                 190         


Met Glu Glu Asn Thr Tyr Pro Ser Phe Leu Lys Ser Asp Ile Tyr Leu 
        195                 200                 205             


Glu Tyr Thr Arg Thr Gly Ser Glu Ser Pro Lys Val Cys Ser Asp Gln 
    210                 215                 220                 


Ser Ser Gly Ser Gly Thr Gly Lys Gly Ile Ser Gly Tyr Leu Pro Thr 
225                 230                 235                 240 


Leu Asn Glu Asp Glu Glu Trp Lys Cys Asp Gln Asp Met Asp Glu Asp 
                245                 250                 255     


Asp Gly Arg Asp Ala Ala Pro Pro Gly Arg Leu Pro Gln Lys Leu Leu 
            260                 265                 270         


Leu Glu Thr Ala Ala Pro Arg Val Ser Ser Ser Arg Arg Tyr Ser Glu 
        275                 280                 285             


Gly Arg Glu Phe Arg Tyr Gly Ser Trp Arg Glu Pro Val Asn Pro Tyr 
    290                 295                 300                 


Tyr Val Asn Ala Gly Tyr Ala Leu Ala Pro Ala Thr Ser Ala Asn Asp 
305                 310                 315                 320 


Ser Glu Gln Gln Ser Leu Ser Ser Asp Ala Asp Thr Leu Ser Leu Thr 
                325                 330                 335     


Asp Ser Ser Val Asp Gly Ile Pro Pro Tyr Arg Ile Arg Lys Gln His 
            340                 345                 350         


Arg Arg Glu Met Gln Glu Ser Val Gln Val Asn Gly Arg Val Pro Leu 
        355                 360                 365             


Pro His Ile Pro Arg Thr Tyr Arg Val Pro Lys Glu Val Arg Val Glu 
    370                 375                 380                 


Pro Gln Lys Phe Ala Glu Glu Leu Ile His Arg Leu Glu Ala Val Gln 
385                 390                 395                 400 


Arg Thr Arg Glu Ala Glu Glu Lys Leu Glu Glu Arg Leu Lys Arg Val 
                405                 410                 415     


Arg Met Glu Glu Glu Gly Glu Asp Gly Asp Pro Ser Ser Gly Pro Pro 
            420                 425                 430         


Gly Pro Cys His Lys Leu Pro Pro Ala Pro Ala Trp His His Phe Pro 
        435                 440                 445             


Pro Arg Cys Val Asp Met Gly Cys Ala Gly Leu Arg Asp Ala His Glu 
    450                 455                 460                 


Glu Asn Pro Glu Ser Ile Leu Asp Glu His Val Gln Arg Val Leu Arg 
465                 470                 475                 480 


Thr Pro Gly Arg Gln Ser Pro Gly Pro Gly His Arg Ser Pro Asp Ser 
                485                 490                 495     


Gly His Val Ala Lys Met Pro Val Ala Leu Gly Gly Ala Ala Ser Gly 
            500                 505                 510         


His Gly Lys His Val Pro Lys Ser Gly Ala Lys Leu Asp Ala Ala Gly 
        515                 520                 525             


Leu His His His Arg His Val His His His Val His His Ser Thr Ala 
    530                 535                 540                 


Arg Pro Lys Glu Gln Val Glu Ala Glu Ala Thr Arg Arg Ala Gln Ser 
545                 550                 555                 560 


Ser Phe Ala Trp Gly Leu Glu Pro His Ser His Gly Ala Arg Ser Arg 
                565                 570                 575     


Gly Tyr Ser Glu Ser Val Gly Ala Ala Pro Asn Ala Ser Asp Gly Leu 
            580                 585                 590         


Ala His Ser Gly Lys Val Gly Val Ala Cys Lys Arg Asn Ala Lys Lys 
        595                 600                 605             


Ala Glu Ser Gly Lys Ser Ala Ser Thr Glu Val Pro Gly Ala Ser Glu 
    610                 615                 620                 


Asp Ala Glu Lys Asn Gln Lys Ile Met Gln Trp Ile Ile Glu Gly Glu 
625                 630                 635                 640 


Lys Glu Ile Ser Arg His Arg Arg Thr Gly His Gly Ser Ser Gly Thr 
                645                 650                 655     


Arg Lys Pro Gln Pro His Glu Asn Ser Arg Pro Leu Ser Leu Glu His 
            660                 665                 670         


Pro Trp Ala Gly Pro Gln Leu Arg Thr Ser Val Gln Pro Ser His Leu 
        675                 680                 685             


Phe Ile Gln Asp Pro Thr Met Pro Pro His Pro Ala Pro Asn Pro Leu 
    690                 695                 700                 


Thr Gln Leu Glu Glu Ala Arg Arg Arg Leu Glu Glu Glu Glu Lys Arg 
705                 710                 715                 720 


Ala Ser Arg Ala Pro Ser Lys Gln Arg Tyr Val Gln Glu Val Met Arg 
                725                 730                 735     


Arg Gly Arg Ala Cys Val Arg Pro Ala Cys Ala Pro Val Leu His Val 
            740                 745                 750         


Val Pro Ala Val Ser Asp Met Glu Leu Ser Glu Thr Glu Thr Arg Ser 
        755                 760                 765             


Gln Arg Lys Val Gly Gly Gly Ser Ala Gln Pro Cys Asp Ser Ile Val 
    770                 775                 780                 


Val Ala Tyr Tyr Phe Cys Gly Glu Pro Ile Pro Tyr Arg Thr Leu Val 
785                 790                 795                 800 


Arg Gly Arg Ala Val Thr Leu Gly Gln Phe Lys Glu Leu Leu Thr Lys 
                805                 810                 815     


Lys Gly Ser Tyr Arg Tyr Tyr Phe Lys Lys Val Ser Asp Glu Phe Asp 
            820                 825                 830         


Cys Gly Val Val Phe Glu Glu Val Arg Glu Asp Glu Ala Val Leu Pro 
        835                 840                 845             


Val Phe Glu Glu Lys Ile Ile Gly Lys Val Glu Lys Val Asp 
    850                 855                 860         


<210>  4
<211>  843
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ser Ala Met Leu Val Thr Cys Leu Pro Asp Pro Ser Ser Ser 
1               5                   10                  15      


Phe Arg Glu Asp Ala Pro Arg Pro Pro Val Pro Gly Glu Glu Gly Glu 
            20                  25                  30          


Thr Pro Pro Cys Gln Pro Gly Val Gly Lys Gly Gln Val Thr Lys Pro 
        35                  40                  45              


Met Ser Val Ser Ser Asn Thr Arg Arg Asn Glu Asp Gly Leu Gly Glu 
    50                  55                  60                  


Pro Glu Gly Arg Ala Ser Pro Asp Ser Pro Leu Thr Arg Trp Thr Lys 
65                  70                  75                  80  


Ser Leu His Ser Leu Leu Gly Asp Gln Asp Gly Ala Tyr Leu Phe Arg 
                85                  90                  95      


Thr Phe Leu Glu Arg Glu Lys Cys Val Asp Thr Leu Asp Phe Trp Phe 
            100                 105                 110         


Ala Cys Asn Gly Phe Arg Gln Met Asn Leu Lys Asp Thr Lys Thr Leu 
        115                 120                 125             


Arg Val Ala Lys Ala Ile Tyr Lys Arg Tyr Ile Glu Asn Asn Ser Ile 
    130                 135                 140                 


Val Ser Lys Gln Leu Lys Pro Ala Thr Lys Thr Tyr Ile Arg Asp Gly 
145                 150                 155                 160 


Ile Lys Lys Gln Gln Ile Asp Ser Ile Met Phe Asp Gln Ala Gln Thr 
                165                 170                 175     


Glu Ile Gln Ser Val Met Glu Glu Asn Ala Tyr Gln Met Phe Leu Thr 
            180                 185                 190         


Ser Asp Ile Tyr Leu Glu Tyr Val Arg Ser Gly Gly Glu Asn Thr Ala 
        195                 200                 205             


Tyr Met Ser Asn Gly Gly Leu Gly Ser Leu Lys Val Val Cys Gly Tyr 
    210                 215                 220                 


Leu Pro Thr Leu Asn Glu Glu Glu Glu Trp Thr Cys Ala Asp Phe Lys 
225                 230                 235                 240 


Cys Lys Leu Ser Pro Thr Val Val Gly Leu Ser Ser Lys Thr Leu Arg 
                245                 250                 255     


Ala Thr Ala Ser Val Arg Ser Thr Glu Thr Val Asp Ser Gly Tyr Arg 
            260                 265                 270         


Ser Phe Lys Arg Ser Asp Pro Val Asn Pro Tyr His Ile Gly Ser Gly 
        275                 280                 285             


Tyr Val Phe Ala Pro Ala Thr Ser Ala Asn Asp Ser Glu Ile Ser Ser 
    290                 295                 300                 


Asp Ala Leu Thr Asp Asp Ser Met Ser Met Thr Asp Ser Ser Val Asp 
305                 310                 315                 320 


Gly Ile Pro Pro Tyr Arg Val Gly Ser Lys Lys Gln Leu Gln Arg Glu 
                325                 330                 335     


Met His Arg Ser Val Lys Ala Asn Gly Gln Val Ser Leu Pro His Phe 
            340                 345                 350         


Pro Arg Thr His Arg Leu Pro Lys Glu Met Thr Pro Val Glu Pro Ala 
        355                 360                 365             


Thr Phe Ala Ala Glu Leu Ile Ser Arg Leu Glu Lys Leu Lys Leu Glu 
    370                 375                 380                 


Leu Glu Ser Arg His Ser Leu Glu Glu Arg Leu Gln Gln Ile Arg Glu 
385                 390                 395                 400 


Asp Glu Glu Arg Glu Gly Ser Glu Leu Thr Leu Asn Ser Arg Glu Gly 
                405                 410                 415     


Ala Pro Thr Gln His Pro Leu Ser Leu Leu Pro Ser Gly Ser Tyr Glu 
            420                 425                 430         


Glu Asp Pro Gln Thr Ile Leu Asp Asp His Leu Ser Arg Val Leu Lys 
        435                 440                 445             


Thr Pro Gly Cys Gln Ser Pro Gly Val Gly Arg Tyr Ser Pro Arg Ser 
    450                 455                 460                 


Arg Ser Pro Asp His His His His His His Ser Gln Tyr His Ser Leu 
465                 470                 475                 480 


Leu Pro Pro Gly Gly Lys Leu Pro Pro Ala Ala Ala Ser Pro Gly Ala 
                485                 490                 495     


Cys Pro Leu Leu Gly Gly Lys Gly Phe Val Thr Lys Gln Thr Thr Lys 
            500                 505                 510         


His Val His His His Tyr Ile His His His Ala Val Pro Lys Thr Lys 
        515                 520                 525             


Glu Glu Ile Glu Ala Glu Ala Thr Gln Arg Val His Cys Phe Cys Pro 
    530                 535                 540                 


Gly Gly Ser Glu Tyr Tyr Cys Tyr Ser Lys Cys Lys Ser His Ser Lys 
545                 550                 555                 560 


Ala Pro Glu Thr Met Pro Ser Glu Gln Phe Gly Gly Ser Arg Gly Ser 
                565                 570                 575     


Thr Leu Pro Lys Arg Asn Gly Lys Gly Thr Glu Pro Gly Leu Ala Leu 
            580                 585                 590         


Pro Ala Arg Glu Gly Gly Ala Pro Gly Gly Ala Gly Ala Leu Gln Leu 
        595                 600                 605             


Pro Arg Glu Glu Gly Asp Arg Ser Gln Asp Val Trp Gln Trp Met Leu 
    610                 615                 620                 


Glu Ser Glu Arg Gln Ser Lys Pro Lys Pro His Ser Ala Gln Ser Thr 
625                 630                 635                 640 


Lys Lys Ala Tyr Pro Leu Glu Ser Ala Arg Ser Ser Pro Gly Glu Arg 
                645                 650                 655     


Ala Ser Arg His His Leu Trp Gly Gly Asn Ser Gly His Pro Arg Thr 
            660                 665                 670         


Thr Pro Arg Ala His Leu Phe Thr Gln Asp Pro Ala Met Pro Pro Leu 
        675                 680                 685             


Thr Pro Pro Asn Thr Leu Ala Gln Leu Glu Glu Ala Cys Arg Arg Leu 
    690                 695                 700                 


Ala Glu Val Ser Lys Pro Pro Lys Gln Arg Cys Cys Val Ala Ser Gln 
705                 710                 715                 720 


Gln Arg Asp Arg Asn His Ser Ala Thr Val Gln Thr Gly Ala Thr Pro 
                725                 730                 735     


Phe Ser Asn Pro Ser Leu Ala Pro Glu Asp His Lys Glu Pro Lys Lys 
            740                 745                 750         


Leu Ala Gly Val His Ala Leu Gln Ala Ser Glu Leu Val Val Thr Tyr 
        755                 760                 765             


Phe Phe Cys Gly Glu Glu Ile Pro Tyr Arg Arg Met Leu Lys Ala Gln 
    770                 775                 780                 


Ser Leu Thr Leu Gly His Phe Lys Glu Gln Leu Ser Lys Lys Gly Asn 
785                 790                 795                 800 


Tyr Arg Tyr Tyr Phe Lys Lys Ala Ser Asp Glu Phe Ala Cys Gly Ala 
                805                 810                 815     


Val Phe Glu Glu Ile Trp Glu Asp Glu Thr Val Leu Pro Met Tyr Glu 
            820                 825                 830         


Gly Arg Ile Leu Gly Lys Val Glu Arg Ile Asp 
        835                 840             


<210>  5
<211>  420
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  6
<211>  907
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Thr Ser Arg Leu Gly Val Leu Leu Ser Leu Pro Val Leu Leu 
1               5                   10                  15      


Gln Leu Ala Thr Gly Gly Ser Ser Pro Arg Ser Gly Val Leu Leu Arg 
            20                  25                  30          


Gly Cys Pro Thr His Cys His Cys Glu Pro Asp Gly Arg Met Leu Leu 
        35                  40                  45              


Arg Val Asp Cys Ser Asp Leu Gly Leu Ser Glu Leu Pro Ser Asn Leu 
    50                  55                  60                  


Ser Val Phe Thr Ser Tyr Leu Asp Leu Ser Met Asn Asn Ile Ser Gln 
65                  70                  75                  80  


Leu Leu Pro Asn Pro Leu Pro Ser Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ala Gly Asn Ala Leu Thr Tyr Ile Pro Lys Gly Ala Phe Thr Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Val Leu Met Leu Gln Asn Asn Gln Leu Arg His 
        115                 120                 125             


Val Pro Thr Glu Ala Leu Gln Asn Leu Arg Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn His Ile Ser Tyr Val Pro Pro Ser Cys Phe Ser Gly 
145                 150                 155                 160 


Leu His Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Gln Ala Phe Arg Ser Leu Ser Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Lys Ile His His Ile Pro Asp Tyr Ala Phe Gly Asn 
        195                 200                 205             


Leu Ser Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile His Ser 
    210                 215                 220                 


Leu Gly Lys Lys Cys Phe Asp Gly Leu His Ser Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Asn Leu Asp Glu Phe Pro Thr Ala Ile Arg Thr Leu 
                245                 250                 255     


Ser Asn Leu Lys Glu Leu Gly Phe His Ser Asn Asn Ile Arg Ser Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Val Gly Asn Pro Ser Leu Ile Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln His Leu 
    290                 295                 300                 


Pro Glu Leu Arg Thr Leu Thr Leu Asn Gly Ala Ser Gln Ile Thr Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Thr Gly Thr Ala Asn Leu Glu Ser Leu Thr Leu Thr 
                325                 330                 335     


Gly Ala Gln Ile Ser Ser Leu Pro Gln Thr Val Cys Asn Gln Leu Pro 
            340                 345                 350         


Asn Leu Gln Val Leu Asp Leu Ser Tyr Asn Leu Leu Glu Asp Leu Pro 
        355                 360                 365             


Ser Phe Ser Val Cys Gln Lys Leu Gln Lys Ile Asp Leu Arg His Asn 
    370                 375                 380                 


Glu Ile Tyr Glu Ile Lys Val Asp Thr Phe Gln Gln Leu Leu Ser Leu 
385                 390                 395                 400 


Arg Ser Leu Asn Leu Ala Trp Asn Lys Ile Ala Ile Ile His Pro Asn 
                405                 410                 415     


Ala Phe Ser Thr Leu Pro Ser Leu Ile Lys Leu Asp Leu Ser Ser Asn 
            420                 425                 430         


Leu Leu Ser Ser Phe Pro Ile Thr Gly Leu His Gly Leu Thr His Leu 
        435                 440                 445             


Lys Leu Thr Gly Asn His Ala Leu Gln Ser Leu Ile Ser Ser Glu Asn 
    450                 455                 460                 


Phe Pro Glu Leu Lys Val Ile Glu Met Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Ala Phe Gly Val Cys Glu Asn Ala Tyr Lys Ile Ser Asn Gln Trp Asn 
                485                 490                 495     


Lys Gly Asp Asn Ser Ser Met Asp Asp Leu His Lys Lys Asp Ala Gly 
            500                 505                 510         


Met Phe Gln Ala Gln Asp Glu Arg Asp Leu Glu Asp Phe Leu Leu Asp 
        515                 520                 525             


Phe Glu Glu Asp Leu Lys Ala Leu His Ser Val Gln Cys Ser Pro Ser 
    530                 535                 540                 


Pro Gly Pro Phe Lys Pro Cys Glu His Leu Leu Asp Gly Trp Leu Ile 
545                 550                 555                 560 


Arg Ile Gly Val Trp Thr Ile Ala Val Leu Ala Leu Thr Cys Asn Ala 
                565                 570                 575     


Leu Val Thr Ser Thr Val Phe Arg Ser Pro Leu Tyr Ile Ser Pro Ile 
            580                 585                 590         


Lys Leu Leu Ile Gly Val Ile Ala Ala Val Asn Met Leu Thr Gly Val 
        595                 600                 605             


Ser Ser Ala Val Leu Ala Gly Val Asp Ala Phe Thr Phe Gly Ser Phe 
    610                 615                 620                 


Ala Arg His Gly Ala Trp Trp Glu Asn Gly Val Gly Cys His Val Ile 
625                 630                 635                 640 


Gly Phe Leu Ser Ile Phe Ala Ser Glu Ser Ser Val Phe Leu Leu Thr 
                645                 650                 655     


Leu Ala Ala Leu Glu Arg Gly Phe Ser Val Lys Tyr Ser Ala Lys Phe 
            660                 665                 670         


Glu Thr Lys Ala Pro Phe Ser Ser Leu Lys Val Ile Ile Leu Leu Cys 
        675                 680                 685             


Ala Leu Leu Ala Leu Thr Met Ala Ala Val Pro Leu Leu Gly Gly Ser 
    690                 695                 700                 


Lys Tyr Gly Ala Ser Pro Leu Cys Leu Pro Leu Pro Phe Gly Glu Pro 
705                 710                 715                 720 


Ser Thr Met Gly Tyr Met Val Ala Leu Ile Leu Leu Asn Ser Leu Cys 
                725                 730                 735     


Phe Leu Met Met Thr Ile Ala Tyr Thr Lys Leu Tyr Cys Asn Leu Asp 
            740                 745                 750         


Lys Gly Asp Leu Glu Asn Ile Trp Asp Cys Ser Met Val Lys His Ile 
        755                 760                 765             


Ala Leu Leu Leu Phe Thr Asn Cys Ile Leu Asn Cys Pro Val Ala Phe 
    770                 775                 780                 


Leu Ser Phe Ser Ser Leu Ile Asn Leu Thr Phe Ile Ser Pro Glu Val 
785                 790                 795                 800 


Ile Lys Phe Ile Leu Leu Val Val Val Pro Leu Pro Ala Cys Leu Asn 
                805                 810                 815     


Pro Leu Leu Tyr Ile Leu Phe Asn Pro His Phe Lys Glu Asp Leu Val 
            820                 825                 830         


Ser Leu Arg Lys Gln Thr Tyr Val Trp Thr Arg Ser Lys His Pro Ser 
        835                 840                 845             


Leu Met Ser Ile Asn Ser Asp Asp Val Glu Lys Gln Ser Cys Asp Ser 
    850                 855                 860                 


Thr Gln Ala Leu Val Thr Phe Thr Ser Ser Ser Ile Thr Tyr Asp Leu 
865                 870                 875                 880 


Pro Pro Ser Ser Val Pro Ser Pro Ala Tyr Pro Val Thr Glu Ser Cys 
                885                 890                 895     


His Leu Ser Ser Val Ala Phe Val Pro Cys Leu 
            900                 905         


<210>  7
<211>  783
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ser Gly Gly His Gln Leu Gln Leu Ala Ala Leu Trp Pro Trp Leu 
1               5                   10                  15      


Leu Met Ala Thr Leu Gln Ala Gly Phe Gly Arg Thr Gly Leu Val Leu 
            20                  25                  30          


Ala Ala Ala Val Glu Ser Glu Arg Ser Ala Glu Gln Lys Ala Ile Ile 
        35                  40                  45              


Arg Val Ile Pro Leu Lys Met Asp Pro Thr Gly Lys Leu Asn Leu Thr 
    50                  55                  60                  


Leu Glu Gly Val Phe Ala Gly Val Ala Glu Ile Thr Pro Ala Glu Gly 
65                  70                  75                  80  


Lys Leu Met Gln Ser His Pro Leu Tyr Leu Cys Asn Ala Ser Asp Asp 
                85                  90                  95      


Asp Asn Leu Glu Pro Gly Phe Ile Ser Ile Val Lys Leu Glu Ser Pro 
            100                 105                 110         


Arg Arg Ala Pro Arg Pro Cys Leu Ser Leu Ala Ser Lys Ala Arg Met 
        115                 120                 125             


Ala Gly Glu Arg Gly Ala Ser Ala Val Leu Phe Asp Ile Thr Glu Asp 
    130                 135                 140                 


Arg Ala Ala Ala Glu Gln Leu Gln Gln Pro Leu Gly Leu Thr Trp Pro 
145                 150                 155                 160 


Val Val Leu Ile Trp Gly Asn Asp Ala Glu Lys Leu Met Glu Phe Val 
                165                 170                 175     


Tyr Lys Asn Gln Lys Ala His Val Arg Ile Glu Leu Lys Glu Pro Pro 
            180                 185                 190         


Ala Trp Pro Asp Tyr Asp Val Trp Ile Leu Met Thr Val Val Gly Thr 
        195                 200                 205             


Ile Phe Val Ile Ile Leu Ala Ser Val Leu Arg Ile Arg Cys Arg Pro 
    210                 215                 220                 


Arg His Ser Arg Pro Asp Pro Leu Gln Gln Arg Thr Ala Trp Ala Ile 
225                 230                 235                 240 


Ser Gln Leu Ala Thr Arg Arg Tyr Gln Ala Ser Cys Arg Gln Ala Arg 
                245                 250                 255     


Gly Glu Trp Pro Asp Ser Gly Ser Ser Cys Ser Ser Ala Pro Val Cys 
            260                 265                 270         


Ala Ile Cys Leu Glu Glu Phe Ser Glu Gly Gln Glu Leu Arg Val Ile 
        275                 280                 285             


Ser Cys Leu His Glu Phe His Arg Asn Cys Val Asp Pro Trp Leu His 
    290                 295                 300                 


Gln His Arg Thr Cys Pro Leu Cys Met Phe Asn Ile Thr Glu Gly Asp 
305                 310                 315                 320 


Ser Phe Ser Gln Ser Leu Gly Pro Ser Arg Ser Tyr Gln Glu Pro Gly 
                325                 330                 335     


Arg Arg Leu His Leu Ile Arg Gln His Pro Gly His Ala His Tyr His 
            340                 345                 350         


Leu Pro Ala Ala Tyr Leu Leu Gly Pro Ser Arg Ser Ala Val Ala Arg 
        355                 360                 365             


Pro Pro Arg Pro Gly Pro Phe Leu Pro Ser Gln Glu Pro Gly Met Gly 
    370                 375                 380                 


Pro Arg His His Arg Phe Pro Arg Ala Ala His Pro Arg Ala Pro Gly 
385                 390                 395                 400 


Glu Gln Gln Arg Leu Ala Gly Ala Gln His Pro Tyr Ala Gln Gly Trp 
                405                 410                 415     


Gly Leu Ser His Leu Gln Ser Thr Ser Gln His Pro Ala Ala Cys Pro 
            420                 425                 430         


Val Pro Leu Arg Arg Ala Arg Pro Pro Asp Ser Ser Gly Ser Gly Glu 
        435                 440                 445             


Ser Tyr Cys Thr Glu Arg Ser Gly Tyr Leu Ala Asp Gly Pro Ala Ser 
    450                 455                 460                 


Asp Ser Ser Ser Gly Pro Cys His Gly Ser Ser Ser Asp Ser Val Val 
465                 470                 475                 480 


Asn Cys Thr Asp Ile Ser Leu Gln Gly Val His Gly Ser Ser Ser Thr 
                485                 490                 495     


Phe Cys Ser Ser Leu Ser Ser Asp Phe Asp Pro Leu Val Tyr Cys Ser 
            500                 505                 510         


Pro Lys Gly Asp Pro Gln Arg Val Asp Met Gln Pro Ser Val Thr Ser 
        515                 520                 525             


Arg Pro Arg Ser Leu Asp Ser Val Val Pro Thr Gly Glu Thr Gln Val 
    530                 535                 540                 


Ser Ser His Val His Tyr His Arg His Arg His His His Tyr Lys Lys 
545                 550                 555                 560 


Arg Phe Gln Trp His Gly Arg Lys Pro Gly Pro Glu Thr Gly Val Pro 
                565                 570                 575     


Gln Ser Arg Pro Pro Ile Pro Arg Thr Gln Pro Gln Pro Glu Pro Pro 
            580                 585                 590         


Ser Pro Asp Gln Gln Val Thr Arg Ser Asn Ser Ala Ala Pro Ser Gly 
        595                 600                 605             


Arg Leu Ser Asn Pro Gln Cys Pro Arg Ala Leu Pro Glu Pro Ala Pro 
    610                 615                 620                 


Gly Pro Val Asp Ala Ser Ser Ile Cys Pro Ser Thr Ser Ser Leu Phe 
625                 630                 635                 640 


Asn Leu Gln Lys Ser Ser Leu Ser Ala Arg His Pro Gln Arg Lys Arg 
                645                 650                 655     


Arg Gly Gly Pro Ser Glu Pro Thr Pro Gly Ser Arg Pro Gln Asp Ala 
            660                 665                 670         


Thr Val His Pro Ala Cys Gln Ile Phe Pro His Tyr Thr Pro Ser Val 
        675                 680                 685             


Ala Tyr Pro Trp Ser Pro Glu Ala His Pro Leu Ile Cys Gly Pro Pro 
    690                 695                 700                 


Gly Leu Asp Lys Arg Leu Leu Pro Glu Thr Pro Gly Pro Cys Tyr Ser 
705                 710                 715                 720 


Asn Ser Gln Pro Val Trp Leu Cys Leu Thr Pro Arg Gln Pro Leu Glu 
                725                 730                 735     


Pro His Pro Pro Gly Glu Gly Pro Ser Glu Trp Ser Ser Asp Thr Ala 
            740                 745                 750         


Glu Gly Arg Pro Cys Pro Tyr Pro His Cys Gln Val Leu Ser Ala Gln 
        755                 760                 765             


Pro Gly Ser Glu Glu Glu Leu Glu Glu Leu Cys Glu Gln Ala Val 
    770                 775                 780             


<210>  8
<211>  936
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Arg Ser Gly Gly Arg Pro Gly Ala Thr Gly Arg Arg Arg 
1               5                   10                  15      


Arg Arg Leu Arg Arg Arg Pro Arg Gly Leu Arg Cys Ser Arg Leu Pro 
            20                  25                  30          


Pro Pro Pro Pro Leu Pro Leu Leu Leu Gly Leu Leu Leu Ala Ala Ala 
        35                  40                  45              


Gly Pro Gly Ala Ala Arg Ala Lys Glu Thr Ala Phe Val Glu Val Val 
    50                  55                  60                  


Leu Phe Glu Ser Ser Pro Ser Gly Asp Tyr Thr Thr Tyr Thr Thr Gly 
65                  70                  75                  80  


Leu Thr Gly Arg Phe Ser Arg Ala Gly Ala Thr Leu Ser Ala Glu Gly 
                85                  90                  95      


Glu Ile Val Gln Met His Pro Leu Gly Leu Cys Asn Asn Asn Asp Glu 
            100                 105                 110         


Glu Asp Leu Tyr Glu Tyr Gly Trp Val Gly Val Val Lys Leu Glu Gln 
        115                 120                 125             


Pro Glu Leu Asp Pro Lys Pro Cys Leu Thr Val Leu Gly Lys Ala Lys 
    130                 135                 140                 


Arg Ala Val Gln Arg Gly Ala Thr Ala Val Ile Phe Asp Val Ser Glu 
145                 150                 155                 160 


Asn Pro Glu Ala Ile Asp Gln Leu Asn Gln Gly Ser Glu Asp Pro Leu 
                165                 170                 175     


Lys Arg Pro Val Val Tyr Val Lys Gly Ala Asp Ala Ile Lys Leu Met 
            180                 185                 190         


Asn Ile Val Asn Lys Gln Lys Val Ala Arg Ala Arg Ile Gln His Arg 
        195                 200                 205             


Pro Pro Arg Gln Pro Thr Glu Tyr Phe Asp Met Gly Ile Phe Leu Ala 
    210                 215                 220                 


Phe Phe Val Val Val Ser Leu Val Cys Leu Ile Leu Leu Val Lys Ile 
225                 230                 235                 240 


Lys Leu Lys Gln Arg Arg Ser Gln Asn Ser Met Asn Arg Leu Ala Val 
                245                 250                 255     


Gln Ala Leu Glu Lys Met Glu Thr Arg Lys Phe Asn Ser Lys Ser Lys 
            260                 265                 270         


Gly Arg Arg Glu Gly Ser Cys Gly Ala Leu Asp Thr Leu Ser Ser Ser 
        275                 280                 285             


Ser Thr Ser Asp Cys Ala Ile Cys Leu Glu Lys Tyr Ile Asp Gly Glu 
    290                 295                 300                 


Glu Leu Arg Val Ile Pro Cys Thr His Arg Phe His Arg Lys Cys Val 
305                 310                 315                 320 


Asp Pro Trp Leu Leu Gln His His Thr Cys Pro His Cys Arg His Asn 
                325                 330                 335     


Ile Ile Glu Gln Lys Gly Asn Pro Ser Ala Val Cys Val Glu Thr Ser 
            340                 345                 350         


Asn Leu Ser Arg Gly Arg Gln Gln Arg Val Thr Leu Pro Val His Tyr 
        355                 360                 365             


Pro Gly Arg Val His Arg Thr Asn Ala Ile Pro Ala Tyr Pro Thr Arg 
    370                 375                 380                 


Thr Ser Met Asp Ser His Gly Asn Pro Val Thr Leu Leu Thr Met Asp 
385                 390                 395                 400 


Arg His Gly Glu Gln Ser Leu Tyr Ser Pro Gln Thr Pro Ala Tyr Ile 
                405                 410                 415     


Arg Ser Tyr Pro Pro Leu His Leu Asp His Ser Leu Ala Ala His Arg 
            420                 425                 430         


Cys Gly Leu Glu His Arg Ala Tyr Ser Pro Ala His Pro Phe Arg Arg 
        435                 440                 445             


Pro Lys Leu Ser Gly Arg Ser Phe Ser Lys Ala Ala Cys Phe Ser Gln 
    450                 455                 460                 


Tyr Glu Thr Met Tyr Gln His Tyr Tyr Phe Gln Gly Leu Ser Tyr Pro 
465                 470                 475                 480 


Glu Gln Glu Gly Gln Ser Pro Pro Ser Leu Ala Pro Arg Gly Pro Ala 
                485                 490                 495     


Arg Ala Phe Pro Pro Ser Gly Ser Gly Ser Leu Leu Phe Pro Thr Val 
            500                 505                 510         


Val His Val Ala Pro Pro Ser His Leu Glu Ser Gly Ser Thr Ser Ser 
        515                 520                 525             


Phe Ser Cys Tyr His Gly His Arg Ser Val Cys Ser Gly Tyr Leu Ala 
    530                 535                 540                 


Asp Cys Pro Gly Ser Asp Ser Ser Ser Ser Ser Ser Ser Gly Gln Cys 
545                 550                 555                 560 


His Cys Ser Ser Ser Asp Ser Val Val Asp Cys Thr Glu Val Ser Asn 
                565                 570                 575     


Gln Gly Val Tyr Gly Ser Cys Ser Thr Phe Arg Ser Ser Leu Ser Ser 
            580                 585                 590         


Asp Tyr Asp Pro Phe Ile Tyr Arg Ser Arg Ser Pro Cys Arg Ala Ser 
        595                 600                 605             


Glu Ala Gly Gly Ser Gly Ser Ser Gly Arg Gly Pro Ala Leu Cys Phe 
    610                 615                 620                 


Glu Gly Ser Pro Pro Pro Glu Glu Leu Pro Ala Val His Ser His Gly 
625                 630                 635                 640 


Ala Gly Arg Gly Glu Pro Trp Pro Gly Pro Ala Ser Pro Ser Gly Asp 
                645                 650                 655     


Gln Val Ser Thr Cys Ser Leu Glu Met Asn Tyr Ser Ser Asn Ser Ser 
            660                 665                 670         


Leu Glu His Arg Gly Pro Asn Ser Ser Thr Ser Glu Val Gly Leu Glu 
        675                 680                 685             


Ala Ser Pro Gly Ala Ala Pro Asp Leu Arg Arg Thr Trp Lys Gly Gly 
    690                 695                 700                 


His Glu Leu Pro Ser Cys Ala Cys Cys Cys Glu Pro Gln Pro Ser Pro 
705                 710                 715                 720 


Ala Gly Pro Ser Ala Gly Ala Ala Gly Ser Ser Thr Leu Phe Leu Gly 
                725                 730                 735     


Pro His Leu Tyr Glu Gly Ser Gly Pro Ala Gly Gly Glu Pro Gln Ser 
            740                 745                 750         


Gly Ser Ser Gln Gly Leu Tyr Gly Leu His Pro Asp His Leu Pro Arg 
        755                 760                 765             


Thr Asp Gly Val Lys Tyr Glu Gly Leu Pro Cys Cys Phe Tyr Glu Glu 
    770                 775                 780                 


Lys Gln Val Ala Arg Gly Gly Gly Gly Gly Ser Gly Cys Tyr Thr Glu 
785                 790                 795                 800 


Asp Tyr Ser Val Ser Val Gln Tyr Thr Leu Thr Glu Glu Pro Pro Pro 
                805                 810                 815     


Gly Cys Tyr Pro Gly Ala Arg Asp Leu Ser Gln Arg Ile Pro Ile Ile 
            820                 825                 830         


Pro Glu Asp Val Asp Cys Asp Leu Gly Leu Pro Ser Asp Cys Gln Gly 
        835                 840                 845             


Thr His Ser Leu Gly Ser Trp Gly Gly Thr Arg Gly Pro Asp Thr Pro 
    850                 855                 860                 


Arg Pro His Arg Gly Leu Gly Ala Thr Arg Glu Glu Glu Arg Ala Leu 
865                 870                 875                 880 


Cys Cys Gln Ala Arg Ala Leu Leu Arg Pro Gly Cys Pro Pro Glu Glu 
                885                 890                 895     


Ala Gly Ala Val Arg Ala Asn Phe Pro Ser Ala Leu Gln Asp Thr Gln 
            900                 905                 910         


Glu Ser Ser Thr Thr Ala Thr Glu Ala Ala Gly Pro Arg Ser His Ser 
        915                 920                 925             


Ala Asp Ser Ser Ser Pro Gly Ala 
    930                 935     


<210>  9
<211>  1613
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Gly Ala Val Leu Arg Ser Leu Leu Ala Cys Ser Phe Cys Val Leu 
1               5                   10                  15      


Leu Arg Ala Ala Pro Leu Leu Leu Tyr Ala Asn Arg Arg Asp Leu Arg 
            20                  25                  30          


Leu Val Asp Ala Thr Asn Gly Lys Glu Asn Ala Thr Ile Val Val Gly 
        35                  40                  45              


Gly Leu Glu Asp Ala Ala Ala Val Asp Phe Val Phe Ser His Gly Leu 
    50                  55                  60                  


Ile Tyr Trp Ser Asp Val Ser Glu Glu Ala Ile Lys Arg Thr Glu Phe 
65                  70                  75                  80  


Asn Lys Thr Glu Ser Val Gln Asn Val Val Val Ser Gly Leu Leu Ser 
                85                  90                  95      


Pro Asp Gly Leu Ala Cys Asp Trp Leu Gly Glu Lys Leu Tyr Trp Thr 
            100                 105                 110         


Asp Ser Glu Thr Asn Arg Ile Glu Val Ser Asn Leu Asp Gly Ser Leu 
        115                 120                 125             


Arg Lys Val Leu Phe Trp Gln Glu Leu Asp Gln Pro Arg Ala Ile Ala 
    130                 135                 140                 


Leu Asp Pro Ser Ser Gly Phe Met Tyr Trp Thr Asp Trp Gly Glu Val 
145                 150                 155                 160 


Pro Lys Ile Glu Arg Ala Gly Met Asp Gly Ser Ser Arg Phe Ile Ile 
                165                 170                 175     


Ile Asn Ser Glu Ile Tyr Trp Pro Asn Gly Leu Thr Leu Asp Tyr Glu 
            180                 185                 190         


Glu Gln Lys Leu Tyr Trp Ala Asp Ala Lys Leu Asn Phe Ile His Lys 
        195                 200                 205             


Ser Asn Leu Asp Gly Thr Asn Arg Gln Ala Val Val Lys Gly Ser Leu 
    210                 215                 220                 


Pro His Pro Phe Ala Leu Thr Leu Phe Glu Asp Ile Leu Tyr Trp Thr 
225                 230                 235                 240 


Asp Trp Ser Thr His Ser Ile Leu Ala Cys Asn Lys Tyr Thr Gly Glu 
                245                 250                 255     


Gly Leu Arg Glu Ile His Ser Asp Ile Phe Ser Pro Met Asp Ile His 
            260                 265                 270         


Ala Phe Ser Gln Gln Arg Gln Pro Asn Ala Thr Asn Pro Cys Gly Ile 
        275                 280                 285             


Asp Asn Gly Gly Cys Ser His Leu Cys Leu Met Ser Pro Val Lys Pro 
    290                 295                 300                 


Phe Tyr Gln Cys Ala Cys Pro Thr Gly Val Lys Leu Leu Glu Asn Gly 
305                 310                 315                 320 


Lys Thr Cys Lys Asp Gly Ala Thr Glu Leu Leu Leu Leu Ala Arg Arg 
                325                 330                 335     


Thr Asp Leu Arg Arg Ile Ser Leu Asp Thr Pro Asp Phe Thr Asp Ile 
            340                 345                 350         


Val Leu Gln Leu Glu Asp Ile Arg His Ala Ile Ala Ile Asp Tyr Asp 
        355                 360                 365             


Pro Val Glu Gly Tyr Ile Tyr Trp Thr Asp Asp Glu Val Arg Ala Ile 
    370                 375                 380                 


Arg Arg Ser Phe Ile Asp Gly Ser Gly Ser Gln Phe Val Val Thr Ala 
385                 390                 395                 400 


Gln Ile Ala His Pro Asp Gly Ile Ala Val Asp Trp Val Ala Arg Asn 
                405                 410                 415     


Leu Tyr Trp Thr Asp Thr Gly Thr Asp Arg Ile Glu Val Thr Arg Leu 
            420                 425                 430         


Asn Gly Thr Met Arg Lys Ile Leu Ile Ser Glu Asp Leu Glu Glu Pro 
        435                 440                 445             


Arg Ala Ile Val Leu Asp Pro Met Val Gly Tyr Met Tyr Trp Thr Asp 
    450                 455                 460                 


Trp Gly Glu Ile Pro Lys Ile Glu Arg Ala Ala Leu Asp Gly Ser Asp 
465                 470                 475                 480 


Arg Val Val Leu Val Asn Thr Ser Leu Gly Trp Pro Asn Gly Leu Ala 
                485                 490                 495     


Leu Asp Tyr Asp Glu Gly Lys Ile Tyr Trp Gly Asp Ala Lys Thr Asp 
            500                 505                 510         


Lys Ile Glu Val Met Asn Thr Asp Gly Thr Gly Arg Arg Val Leu Val 
        515                 520                 525             


Glu Asp Lys Ile Pro His Ile Phe Gly Phe Thr Leu Leu Gly Asp Tyr 
    530                 535                 540                 


Val Tyr Trp Thr Asp Trp Gln Arg Arg Ser Ile Glu Arg Val His Lys 
545                 550                 555                 560 


Arg Ser Ala Glu Arg Glu Val Ile Ile Asp Gln Leu Pro Asp Leu Met 
                565                 570                 575     


Gly Leu Lys Ala Thr Asn Val His Arg Val Ile Gly Ser Asn Pro Cys 
            580                 585                 590         


Ala Glu Glu Asn Gly Gly Cys Ser His Leu Cys Leu Tyr Arg Pro Gln 
        595                 600                 605             


Gly Leu Arg Cys Ala Cys Pro Ile Gly Phe Glu Leu Ile Ser Asp Met 
    610                 615                 620                 


Lys Thr Cys Ile Val Pro Glu Ala Phe Leu Leu Phe Ser Arg Arg Ala 
625                 630                 635                 640 


Asp Ile Arg Arg Ile Ser Leu Glu Thr Asn Asn Asn Asn Val Ala Ile 
                645                 650                 655     


Pro Leu Thr Gly Val Lys Glu Ala Ser Ala Leu Asp Phe Asp Val Thr 
            660                 665                 670         


Asp Asn Arg Ile Tyr Trp Thr Asp Ile Ser Leu Lys Thr Ile Ser Arg 
        675                 680                 685             


Ala Phe Met Asn Gly Ser Ala Leu Glu His Val Val Glu Phe Gly Leu 
    690                 695                 700                 


Asp Tyr Pro Glu Gly Met Ala Val Asp Trp Leu Gly Lys Asn Leu Tyr 
705                 710                 715                 720 


Trp Ala Asp Thr Gly Thr Asn Arg Ile Glu Val Ser Lys Leu Asp Gly 
                725                 730                 735     


Gln His Arg Gln Val Leu Val Trp Lys Asp Leu Asp Ser Pro Arg Ala 
            740                 745                 750         


Leu Ala Leu Asp Pro Ala Glu Gly Phe Met Tyr Trp Thr Glu Trp Gly 
        755                 760                 765             


Gly Lys Pro Lys Ile Asp Arg Ala Ala Met Asp Gly Ser Glu Arg Thr 
    770                 775                 780                 


Thr Leu Val Pro Asn Val Gly Arg Ala Asn Gly Leu Thr Ile Asp Tyr 
785                 790                 795                 800 


Ala Lys Arg Arg Leu Tyr Trp Thr Asp Leu Asp Thr Asn Leu Ile Glu 
                805                 810                 815     


Ser Ser Asn Met Leu Gly Leu Asn Arg Glu Val Ile Ala Asp Asp Leu 
            820                 825                 830         


Pro His Pro Phe Gly Leu Thr Gln Tyr Gln Asp Tyr Ile Tyr Trp Thr 
        835                 840                 845             


Asp Trp Ser Arg Arg Ser Ile Glu Arg Ala Asn Lys Thr Ser Gly Gln 
    850                 855                 860                 


Asn Arg Thr Ile Ile Gln Gly His Leu Asp Tyr Val Met Asp Ile Leu 
865                 870                 875                 880 


Val Phe His Ser Ser Arg Gln Ser Gly Trp Asn Glu Cys Ala Ser Ser 
                885                 890                 895     


Asn Gly His Cys Ser His Leu Cys Leu Ala Val Pro Val Gly Gly Phe 
            900                 905                 910         


Val Cys Gly Cys Pro Ala His Tyr Ser Leu Asn Ala Asp Asn Arg Thr 
        915                 920                 925             


Cys Ser Ala Pro Thr Thr Phe Leu Leu Phe Ser Gln Lys Ser Ala Ile 
    930                 935                 940                 


Asn Arg Met Val Ile Asp Glu Gln Gln Ser Pro Asp Ile Ile Leu Pro 
945                 950                 955                 960 


Ile His Ser Leu Arg Asn Val Arg Ala Ile Asp Tyr Asp Pro Leu Asp 
                965                 970                 975     


Lys Gln Leu Tyr Trp Ile Asp Ser Arg Gln Asn Met Ile Arg Lys Ala 
            980                 985                 990         


Gln Glu Asp Gly Ser Gln Gly Phe  Thr Val Val Val Ser  Ser Val Pro 
        995                 1000                 1005             


Ser Gln  Asn Leu Glu Ile Gln  Pro Tyr Asp Leu Ser  Ile Asp Ile 
    1010                 1015                 1020             


Tyr Ser  Arg Tyr Ile Tyr Trp  Thr Cys Glu Ala Thr  Asn Val Ile 
    1025                 1030                 1035             


Asn Val  Thr Arg Leu Asp Gly  Arg Ser Val Gly Val  Val Leu Lys 
    1040                 1045                 1050             


Gly Glu  Gln Asp Arg Pro Arg  Ala Val Val Val Asn  Pro Glu Lys 
    1055                 1060                 1065             


Gly Tyr  Met Tyr Phe Thr Asn  Leu Gln Glu Arg Ser  Pro Lys Ile 
    1070                 1075                 1080             


Glu Arg  Ala Ala Leu Asp Gly  Thr Glu Arg Glu Val  Leu Phe Phe 
    1085                 1090                 1095             


Ser Gly  Leu Ser Lys Pro Ile  Ala Leu Ala Leu Asp  Ser Arg Leu 
    1100                 1105                 1110             


Gly Lys  Leu Phe Trp Ala Asp  Ser Asp Leu Arg Arg  Ile Glu Ser 
    1115                 1120                 1125             


Ser Asp  Leu Ser Gly Ala Asn  Arg Ile Val Leu Glu  Asp Ser Asn 
    1130                 1135                 1140             


Ile Leu  Gln Pro Val Gly Leu  Thr Val Phe Glu Asn  Trp Leu Tyr 
    1145                 1150                 1155             


Trp Ile  Asp Lys Gln Gln Gln  Met Ile Glu Lys Ile  Asp Met Thr 
    1160                 1165                 1170             


Gly Arg  Glu Gly Arg Thr Lys  Val Gln Ala Arg Ile  Ala Gln Leu 
    1175                 1180                 1185             


Ser Asp  Ile His Ala Val Lys  Glu Leu Asn Leu Gln  Glu Tyr Arg 
    1190                 1195                 1200             


Gln His  Pro Cys Ala Gln Asp  Asn Gly Gly Cys Ser  His Ile Cys 
    1205                 1210                 1215             


Leu Val  Lys Gly Asp Gly Thr  Thr Arg Cys Ser Cys  Pro Met His 
    1220                 1225                 1230             


Leu Val  Leu Leu Gln Asp Glu  Leu Ser Cys Gly Glu  Pro Pro Thr 
    1235                 1240                 1245             


Cys Ser  Pro Gln Gln Phe Thr  Cys Phe Thr Gly Glu  Ile Asp Cys 
    1250                 1255                 1260             


Ile Pro  Val Ala Trp Arg Cys  Asp Gly Phe Thr Glu  Cys Glu Asp 
    1265                 1270                 1275             


His Ser  Asp Glu Leu Asn Cys  Pro Val Cys Ser Glu  Ser Gln Phe 
    1280                 1285                 1290             


Gln Cys  Ala Ser Gly Gln Cys  Ile Asp Gly Ala Leu  Arg Cys Asn 
    1295                 1300                 1305             


Gly Asp  Ala Asn Cys Gln Asp  Lys Ser Asp Glu Lys  Asn Cys Glu 
    1310                 1315                 1320             


Val Leu  Cys Leu Ile Asp Gln  Phe Arg Cys Ala Asn  Gly Gln Cys 
    1325                 1330                 1335             


Ile Gly  Lys His Lys Lys Cys  Asp His Asn Val Asp  Cys Ser Asp 
    1340                 1345                 1350             


Lys Ser  Asp Glu Leu Asp Cys  Tyr Pro Thr Glu Glu  Pro Ala Pro 
    1355                 1360                 1365             


Gln Ala  Thr Asn Thr Val Gly  Ser Val Ile Gly Val  Ile Val Thr 
    1370                 1375                 1380             


Ile Phe  Val Ser Gly Thr Val  Tyr Phe Ile Cys Gln  Arg Met Leu 
    1385                 1390                 1395             


Cys Pro  Arg Met Lys Gly Asp  Gly Glu Thr Met Thr  Asn Asp Tyr 
    1400                 1405                 1410             


Val Val  His Gly Pro Ala Ser  Val Pro Leu Gly Tyr  Val Pro His 
    1415                 1420                 1425             


Pro Ser  Ser Leu Ser Gly Ser  Leu Pro Gly Met Ser  Arg Gly Lys 
    1430                 1435                 1440             


Ser Met  Ile Ser Ser Leu Ser  Ile Met Gly Gly Ser  Ser Gly Pro 
    1445                 1450                 1455             


Pro Tyr  Asp Arg Ala His Val  Thr Gly Ala Ser Ser  Ser Ser Ser 
    1460                 1465                 1470             


Ser Ser  Thr Lys Gly Thr Tyr  Phe Pro Ala Ile Leu  Asn Pro Pro 
    1475                 1480                 1485             


Pro Ser  Pro Ala Thr Glu Arg  Ser His Tyr Thr Met  Glu Phe Gly 
    1490                 1495                 1500             


Tyr Ser  Ser Asn Ser Pro Ser  Thr His Arg Ser Tyr  Ser Tyr Arg 
    1505                 1510                 1515             


Pro Tyr  Ser Tyr Arg His Phe  Ala Pro Pro Thr Thr  Pro Cys Ser 
    1520                 1525                 1530             


Thr Asp  Val Cys Asp Ser Asp  Tyr Ala Pro Ser Arg  Arg Met Thr 
    1535                 1540                 1545             


Ser Val  Ala Thr Ala Lys Gly  Tyr Thr Ser Asp Leu  Asn Tyr Asp 
    1550                 1555                 1560             


Ser Glu  Pro Val Pro Pro Pro  Pro Thr Pro Arg Ser  Gln Tyr Leu 
    1565                 1570                 1575             


Ser Ala  Glu Glu Asn Tyr Glu  Ser Cys Pro Pro Ser  Pro Tyr Thr 
    1580                 1585                 1590             


Glu Arg  Ser Tyr Ser His His  Leu Tyr Pro Pro Pro  Pro Ser Pro 
    1595                 1600                 1605             


Cys Thr  Asp Ser Ser 
    1610             


<210>  10
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  11
<211>  619
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Pro Gln Leu Asn Gly Gly Gly Gly Asp Asp Leu Gly Ala Asn Asp 
1               5                   10                  15      


Glu Leu Ile Ser Phe Lys Asp Glu Gly Glu Gln Glu Glu Lys Ser Ser 
            20                  25                  30          


Glu Asn Ser Ser Ala Glu Arg Asp Leu Ala Asp Val Lys Ser Ser Leu 
        35                  40                  45              


Val Asn Glu Ser Glu Thr Asn Gln Asn Ser Ser Ser Asp Ser Glu Ala 
    50                  55                  60                  


Glu Arg Arg Pro Pro Pro Arg Ser Glu Ser Phe Arg Asp Lys Ser Arg 
65                  70                  75                  80  


Glu Ser Leu Glu Glu Ala Ala Lys Arg Gln Asp Gly Gly Leu Phe Lys 
                85                  90                  95      


Gly Pro Pro Tyr Pro Gly Tyr Pro Phe Ile Met Ile Pro Asp Leu Thr 
            100                 105                 110         


Ser Pro Tyr Leu Pro Asn Gly Ser Leu Ser Pro Thr Ala Arg Thr Leu 
        115                 120                 125             


His Phe Gln Ser Gly Ser Thr His Tyr Ser Ala Tyr Lys Thr Ile Glu 
    130                 135                 140                 


His Gln Ile Ala Val Gln Tyr Leu Gln Met Lys Trp Pro Leu Leu Asp 
145                 150                 155                 160 


Val Gln Ala Gly Ser Leu Gln Ser Arg Gln Ala Leu Lys Asp Ala Arg 
                165                 170                 175     


Ser Pro Ser Pro Ala His Ile Val Ser Asn Lys Val Pro Val Val Gln 
            180                 185                 190         


His Pro His His Val His Pro Leu Thr Pro Leu Ile Thr Tyr Ser Asn 
        195                 200                 205             


Glu His Phe Thr Pro Gly Asn Pro Pro Pro His Leu Pro Ala Asp Val 
    210                 215                 220                 


Asp Pro Lys Thr Gly Ile Pro Arg Pro Pro His Pro Pro Asp Ile Ser 
225                 230                 235                 240 


Pro Tyr Tyr Pro Leu Ser Pro Gly Thr Val Gly Gln Ile Pro His Pro 
                245                 250                 255     


Leu Gly Trp Leu Val Pro Gln Gln Gly Gln Pro Val Tyr Pro Ile Thr 
            260                 265                 270         


Thr Gly Gly Phe Arg His Pro Tyr Pro Thr Ala Leu Thr Val Asn Ala 
        275                 280                 285             


Ser Met Ser Arg Phe Pro Pro His Met Val Pro Pro His His Thr Leu 
    290                 295                 300                 


His Thr Thr Gly Ile Pro His Pro Ala Ile Val Thr Pro Thr Val Lys 
305                 310                 315                 320 


Gln Glu Ser Ser Gln Ser Asp Val Gly Ser Leu His Ser Ser Lys His 
                325                 330                 335     


Gln Asp Ser Lys Lys Glu Glu Glu Lys Lys Lys Pro His Ile Lys Lys 
            340                 345                 350         


Pro Leu Asn Ala Phe Met Leu Tyr Met Lys Glu Met Arg Ala Lys Val 
        355                 360                 365             


Val Ala Glu Cys Thr Leu Lys Glu Ser Ala Ala Ile Asn Gln Ile Leu 
    370                 375                 380                 


Gly Arg Arg Trp His Ala Leu Ser Arg Glu Glu Gln Ala Lys Tyr Tyr 
385                 390                 395                 400 


Glu Leu Ala Arg Lys Glu Arg Gln Leu His Met Gln Leu Tyr Pro Gly 
                405                 410                 415     


Trp Ser Ala Arg Asp Asn Tyr Gly Lys Lys Lys Lys Arg Lys Arg Asp 
            420                 425                 430         


Lys Gln Pro Gly Glu Thr Asn Glu His Ser Glu Cys Phe Leu Asn Pro 
        435                 440                 445             


Cys Leu Ser Leu Pro Pro Ile Thr Asp Leu Ser Ala Pro Lys Lys Cys 
    450                 455                 460                 


Arg Ala Arg Phe Gly Leu Asp Gln Gln Asn Asn Trp Cys Gly Pro Cys 
465                 470                 475                 480 


Arg Arg Lys Lys Lys Cys Val Arg Tyr Ile Gln Gly Glu Gly Ser Cys 
                485                 490                 495     


Leu Ser Pro Pro Ser Ser Asp Gly Ser Leu Leu Asp Ser Pro Pro Pro 
            500                 505                 510         


Ser Pro Asn Leu Leu Gly Ser Pro Pro Arg Asp Ala Lys Ser Gln Thr 
        515                 520                 525             


Glu Gln Thr Gln Pro Leu Ser Leu Ser Leu Lys Pro Asp Pro Leu Ala 
    530                 535                 540                 


His Leu Ser Met Met Pro Pro Pro Pro Ala Leu Leu Leu Ala Glu Ala 
545                 550                 555                 560 


Thr His Lys Ala Ser Ala Leu Cys Pro Asn Gly Ala Leu Asp Leu Pro 
                565                 570                 575     


Pro Ala Ala Leu Gln Pro Ala Ala Pro Ser Ser Ser Ile Ala Gln Pro 
            580                 585                 590         


Ser Thr Ser Ser Leu His Ser His Ser Ser Leu Ala Gly Thr Gln Pro 
        595                 600                 605             


Gln Pro Leu Ser Leu Val Thr Lys Ser Leu Glu 
    610                 615                 


<210>  12
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  CTNNB1-MiSeq-F

<400>  12
tcaatgggtc atatcacaga ttct                                              24


<210>  13
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  CTNNB1-MiSeq-R

<400>  13
tcctcttcct caggattgcc                                                   20


<210>  14
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Axin2-qPCR-F

<400>  14
tgactctcct tccagatccc a                                                 21


<210>  15
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Axin2-qPCR-R

<400>  15
tgcccacact aggctgaca                                                    19


<210>  16
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Jun-qPCR-F

<400>  16
ccttctacga cgatgccctc                                                   20


<210>  17
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Jun-qPCR-R

<400>  17
ggttcaaggt catgctctgt tt                                                22


<210>  18
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Wnt16-qPCR-F

<400>  18
gcaggctgtc gccaagtta                                                    19


<210>  19
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Wnt16-qPCR-R

<400>  19
gtctgcctct ggtctttttc tc                                                22


<210>  20
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Lef1-qPCR-F

<400>  20
tgtttatccc atcacgggtg g                                                 21


<210>  21
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Lef1-qPCR-R

<400>  21
catggaagtg tcgcctgaca g                                                 21


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Gapdh-qPCR-F

<400>  22
tggatttgga cgcattggtc                                                   20


<210>  23
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Gapdh-qPCR-R

<400>  23
tttgcactgg tacgtgttga t                                                 21


<210>  24
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Actb-qPCR-F

<400>  24
ggctgtattc ccctccatcg                                                   20


<210>  25
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Actb-qPCR-R

<400>  25
ccagttggta acaatgccat gt                                                22


<210>  26
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Ezh2-shRNA-1

<400>  26
ccggcggctc ctctaaccat gtttactcga gtaaacatgg ttagaggagc cgtttttg         58


<210>  27
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Ezh2-shRNA-2

<400>  27
ccgggcacaa gtcatcccgt taaagctcga gctttaacgg gatgacttgt gctttttg         58


<210>  28
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  shRNA-Ctrl

<400>  28
ccgggcgcga tagcgctaat aatttctcga gaaattatta gcgctatcgc gcttttt          57


