                         SEQUENCE LISTING

<110>  NeoImmuneTech, Inc.
 
<120>  USE OF INTERLEUKIN-7 FOR THE TREATMENT OF CORONAVIRUS

<130>  4241.022PC01/C-K/DKC

<150> US 63/108,778
<151> 2020-11-02

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  2
<211>  154
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser Asp Cys His Ile Lys Asp Lys 
            20                  25                  30          


Asp Gly Lys Ala Phe Gly Ser Val Leu Met Ile Ser Ile Asn Gln Leu 
        35                  40                  45              


Asp Lys Met Thr Gly Thr Asp Ser Asp Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Lys Lys His Leu Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Glu Glu Phe Asn Asp His Leu Leu Arg Val Ser Asp Gly Thr Gln Thr 
            100                 105                 110         


Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Thr Ile Lys Glu Gln Lys 
        115                 120                 125             


Lys Asn Asp Pro Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile 
145                 150                 


<210>  3
<211>  154
<212>  PRT
<213>  Mus Musculus

<400>  3

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Thr Ser Ser Glu Cys His Ile Lys Asp Lys 
            20                  25                  30          


Glu Gly Lys Ala Tyr Glu Ser Val Leu Met Ile Ser Ile Asp Glu Leu 
        35                  40                  45              


Asp Lys Met Thr Gly Thr Asp Ser Asn Cys Pro Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Arg Lys His Val Cys Asp Asp Thr Lys Glu Ala Ala Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Glu Glu Phe Asn Val His Leu Leu Thr Val Ser Gln Gly Thr Gln Thr 
            100                 105                 110         


Leu Val Asn Cys Thr Ser Lys Glu Glu Lys Asn Val Lys Glu Gln Lys 
        115                 120                 125             


Lys Asn Asp Ala Cys Phe Leu Lys Arg Leu Leu Arg Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Lys Gly Ser Ile 
145                 150                 


<210>  4
<211>  177
<212>  PRT
<213>  Cercopithecus aethiops

<400>  4

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Glu Gly Lys 
            20                  25                  30          


Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu 
        35                  40                  45              


Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe 
    50                  55                  60                  


Asn Phe Phe Lys Arg His Leu Cys Asp Asp Asn Lys Glu Gly Met Phe 
65                  70                  75                  80  


Leu Phe Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ser 
                85                  90                  95      


Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr 
            100                 105                 110         


Ile Leu Leu Asn Cys Thr Gly Lys Val Lys Gly Arg Lys Pro Ala Ala 
        115                 120                 125             


Leu Gly Glu Pro Gln Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu 
    130                 135                 140                 


Lys Glu Gln Lys Lys Leu Asn Asp Ser Cys Phe Leu Lys Arg Leu Leu 
145                 150                 155                 160 


Gln Lys Ile Lys Thr Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu 
                165                 170                 175     


His 
    


<210>  5
<211>  176
<212>  PRT
<213>  Bos taurus

<400>  5

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Ile Ser Gly Lys 
            20                  25                  30          


Asp Gly Gly Ala Tyr Gln Asn Val Leu Met Val Asn Ile Asp Asp Leu 
        35                  40                  45              


Asp Asn Met Ile Asn Phe Asp Ser Asn Cys Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Lys Lys His Ser Cys Asp Asp Asn Lys Glu Ala Ser Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ser Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Asp Asp Phe Lys Leu His Leu Ser Thr Val Ser Gln Gly Thr Leu Thr 
            100                 105                 110         


Leu Leu Asn Cys Thr Ser Lys Gly Lys Gly Arg Lys Pro Pro Ser Leu 
        115                 120                 125             


Ser Glu Ala Gln Pro Thr Lys Asn Leu Glu Glu Asn Lys Ser Ser Lys 
    130                 135                 140                 


Glu Gln Lys Lys Gln Asn Asp Leu Cys Phe Leu Lys Ile Leu Leu Gln 
145                 150                 155                 160 


Lys Ile Lys Thr Cys Trp Asn Lys Ile Leu Arg Gly Ile Lys Glu His 
                165                 170                 175     


<210>  6
<211>  176
<212>  PRT
<213>  Ovis aries

<400>  6

Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Ile Pro Pro Leu Ile 
1               5                   10                  15      


Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp Phe Ser Gly Lys 
            20                  25                  30          


Asp Gly Gly Ala Tyr Gln Asn Val Leu Met Val Ser Ile Asp Asp Leu 
        35                  40                  45              


Asp Asn Met Ile Asn Phe Asp Ser Asn Cys Leu Asn Asn Glu Pro Asn 
    50                  55                  60                  


Phe Phe Lys Lys His Ser Cys Asp Asp Asn Lys Glu Ala Ser Phe Leu 
65                  70                  75                  80  


Asn Arg Ala Ala Arg Lys Leu Lys Gln Phe Leu Lys Met Asn Ile Ser 
                85                  90                  95      


Asp Asp Phe Lys Leu His Leu Ser Thr Val Ser Gln Gly Thr Leu Thr 
            100                 105                 110         


Leu Leu Asn Cys Thr Ser Lys Gly Lys Gly Arg Lys Pro Pro Ser Leu 
        115                 120                 125             


Gly Glu Ala Gln Pro Thr Lys Asn Leu Glu Glu Asn Lys Ser Leu Lys 
    130                 135                 140                 


Glu Gln Arg Lys Gln Asn Asp Leu Cys Phe Leu Lys Ile Leu Leu Gln 
145                 150                 155                 160 


Lys Ile Lys Thr Cys Trp Asn Lys Ile Leu Arg Gly Ile Thr Glu His 
                165                 170                 175     


<210>  7
<211>  384
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human IgD constant region (Genbank 
       accession No. P01880)

<400>  7

Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro 
            100                 105                 110         


Thr Ala Gln Pro Gln Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala 
        115                 120                 125             


Pro Ala Thr Thr Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys 
    130                 135                 140                 


Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu 
145                 150                 155                 160 


Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro Ala 
                165                 170                 175     


Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe Val 
            180                 185                 190         


Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala Gly 
        195                 200                 205             


Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His Ser 
    210                 215                 220                 


Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser Leu 
225                 230                 235                 240 


Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser Leu 
                245                 250                 255     


Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro Ala Ala Gln Ala Pro 
            260                 265                 270         


Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser Asp Pro Pro Glu Ala 
        275                 280                 285             


Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe Ser Pro Pro Asn Ile 
    290                 295                 300                 


Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val Asn Thr Ser Gly Phe 
305                 310                 315                 320 


Ala Pro Ala Arg Pro Pro Pro Gln Pro Gly Ser Thr Thr Phe Trp Ala 
                325                 330                 335     


Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser Pro Gln Pro Ala Thr 
            340                 345                 350         


Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg Thr Leu Leu Asn Ala 
        355                 360                 365             


Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp His Gly Pro Met Lys 
    370                 375                 380                 


<210>  8
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of Partial human IgG4 constant region 
       (Genbank accession No. AAH25985)

<400>  8

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  9
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hyFc

<400>  9

Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys 
1               5                   10                  15      


Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His 
            20                  25                  30          


Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        115                 120                 125             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Leu Gly Lys 
                245 


<210>  10
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hyFcM1

<400>  10

Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Gly Gly Lys Glu Lys 
1               5                   10                  15      


Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His 
            20                  25                  30          


Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        115                 120                 125             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Leu Gly Lys 
                245 


<210>  11
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hyFcM2

<400>  11

Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Gly Ser Lys Glu Lys 
1               5                   10                  15      


Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His 
            20                  25                  30          


Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        115                 120                 125             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Leu Gly Lys 
                245 


<210>  12
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hyFcM3

<400>  12

Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Ser Gly Lys Glu Lys 
1               5                   10                  15      


Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His 
            20                  25                  30          


Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        115                 120                 125             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Leu Gly Lys 
                245 


<210>  13
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of hyFcM4

<400>  13

Arg Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Ser Ser Lys Glu Lys 
1               5                   10                  15      


Glu Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His 
            20                  25                  30          


Thr Gln Pro Leu Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        115                 120                 125             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Leu Gly Lys 
                245 


<210>  14
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of mouse IgG Fc variant

<400>  14

Ala Ser Ala Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys 
1               5                   10                  15      


Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val Phe Ile Phe 
            20                  25                  30          


Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 
    50                  55                  60                  


Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 
65                  70                  75                  80  


His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 
                85                  90                  95      


Ile Gln His Gln Asp Trp Met Ser Gly Lys Ala Phe Ala Cys Ala Val 
            100                 105                 110         


Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 
        115                 120                 125             


Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 
    130                 135                 140                 


Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 
145                 150                 155                 160 


Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 
                165                 170                 175     


Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 
            180                 185                 190         


Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 
        195                 200                 205             


Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 
    210                 215                 220                 


His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly Gly Gly Asn 
225                 230                 235                 240 


Ser Gly Ser 
            


<210>  15
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(M)

<400>  15

Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val 
1               5                   10                  15      


Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly 
            20                  25                  30          


Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys 
        35                  40                  45              


Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu 
    50                  55                  60                  


Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu 
65                  70                  75                  80  


Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln 
                85                  90                  95      


Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys 
            100                 105                 110         


Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp 
        115                 120                 125             


Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn 
    130                 135                 140                 


Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150             


<210>  16
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(MM)

<400>  16

Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
1               5                   10                  15      


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
            20                  25                  30          


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
        35                  40                  45              


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
    50                  55                  60                  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
65                  70                  75                  80  


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
                85                  90                  95      


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
            100                 105                 110         


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
        115                 120                 125             


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
    130                 135                 140                 


Asn Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150                 


<210>  17
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(MMM)

<400>  17

Met Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
1               5                   10                  15      


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
            20                  25                  30          


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
        35                  40                  45              


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
    50                  55                  60                  


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
65                  70                  75                  80  


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
                85                  90                  95      


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
            100                 105                 110         


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
        115                 120                 125             


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
    130                 135                 140                 


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150                 155 


<210>  18
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(MGM)

<400>  18

Met Gly Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
1               5                   10                  15      


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
            20                  25                  30          


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
        35                  40                  45              


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
    50                  55                  60                  


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
65                  70                  75                  80  


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
                85                  90                  95      


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
            100                 105                 110         


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
        115                 120                 125             


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
    130                 135                 140                 


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150                 155 


<210>  19
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(DDD)

<400>  19

Asp Asp Asp Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
1               5                   10                  15      


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
            20                  25                  30          


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
        35                  40                  45              


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
    50                  55                  60                  


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
65                  70                  75                  80  


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
                85                  90                  95      


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
            100                 105                 110         


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
        115                 120                 125             


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
    130                 135                 140                 


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150                 155 


<210>  20
<211>  156
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(MMMM)

<400>  20

Met Met Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr 
1               5                   10                  15      


Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys 
            20                  25                  30          


Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg 
        35                  40                  45              


His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala 
    50                  55                  60                  


Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp 
65                  70                  75                  80  


Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys 
                85                  90                  95      


Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln 
            100                 105                 110         


Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys 
        115                 120                 125             


Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His 
145                 150                 155     


<210>  21
<211>  398
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(M) fused hyFc

<400>  21

Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val 
1               5                   10                  15      


Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly 
            20                  25                  30          


Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys 
        35                  40                  45              


Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu 
    50                  55                  60                  


Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu 
65                  70                  75                  80  


Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln 
                85                  90                  95      


Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys 
            100                 105                 110         


Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp 
        115                 120                 125             


Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn 
    130                 135                 140                 


Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg Gly Gly 
145                 150                 155                 160 


Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu 
                165                 170                 175     


Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Phe 
            180                 185                 190         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        195                 200                 205             


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
    210                 215                 220                 


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
225                 230                 235                 240 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
                245                 250                 255     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            260                 265                 270         


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
        275                 280                 285             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    290                 295                 300                 


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
305                 310                 315                 320 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                325                 330                 335     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
            340                 345                 350         


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
        355                 360                 365             


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    370                 375                 380                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
385                 390                 395             


<210>  22
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(MM) fused hyFc

<400>  22

Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser 
1               5                   10                  15      


Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile 
            20                  25                  30          


Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile 
        35                  40                  45              


Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys 
    50                  55                  60                  


Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His 
65                  70                  75                  80  


Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly 
                85                  90                  95      


Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr 
            100                 105                 110         


Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn 
        115                 120                 125             


Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp 
    130                 135                 140                 


Asn Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg Gly 
145                 150                 155                 160 


Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg 
                165                 170                 175     


Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val 
            180                 185                 190         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        195                 200                 205             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
    210                 215                 220                 


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
225                 230                 235                 240 


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
                245                 250                 255     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            260                 265                 270         


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
        275                 280                 285             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    290                 295                 300                 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
305                 310                 315                 320 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                325                 330                 335     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            340                 345                 350         


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
        355                 360                 365             


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    370                 375                 380                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
385                 390                 395                 


<210>  23
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(MMM) fused hyFc

<400>  23

Met Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
1               5                   10                  15      


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
            20                  25                  30          


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
        35                  40                  45              


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
    50                  55                  60                  


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
65                  70                  75                  80  


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
                85                  90                  95      


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
            100                 105                 110         


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
        115                 120                 125             


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
    130                 135                 140                 


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg 
145                 150                 155                 160 


Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu 
                165                 170                 175     


Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly 
            180                 185                 190         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        195                 200                 205             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
    210                 215                 220                 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
225                 230                 235                 240 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
                245                 250                 255     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            260                 265                 270         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
        275                 280                 285             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    290                 295                 300                 


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
305                 310                 315                 320 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                325                 330                 335     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            340                 345                 350         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
        355                 360                 365             


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    370                 375                 380                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
385                 390                 395                 400 


<210>  24
<211>  400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(MGM) fused hyFc

<400>  24

Met Gly Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu 
1               5                   10                  15      


Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu 
            20                  25                  30          


Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His 
        35                  40                  45              


Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg 
    50                  55                  60                  


Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu 
65                  70                  75                  80  


His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr 
                85                  90                  95      


Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro 
            100                 105                 110         


Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu 
        115                 120                 125             


Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys 
    130                 135                 140                 


Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg 
145                 150                 155                 160 


Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu 
                165                 170                 175     


Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly 
            180                 185                 190         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        195                 200                 205             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
    210                 215                 220                 


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
225                 230                 235                 240 


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
                245                 250                 255     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            260                 265                 270         


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
        275                 280                 285             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    290                 295                 300                 


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
305                 310                 315                 320 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                325                 330                 335     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            340                 345                 350         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
        355                 360                 365             


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    370                 375                 380                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
385                 390                 395                 400 


<210>  25
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of modified IL-7(MMMM) fused hyFc

<400>  25

Met Met Met Met Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr 
1               5                   10                  15      


Glu Ser Val Leu Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys 
            20                  25                  30          


Glu Ile Gly Ser Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg 
        35                  40                  45              


His Ile Cys Asp Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala 
    50                  55                  60                  


Arg Lys Leu Arg Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp 
65                  70                  75                  80  


Leu His Leu Leu Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys 
                85                  90                  95      


Thr Gly Gln Val Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln 
            100                 105                 110         


Pro Thr Lys Ser Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys 
        115                 120                 125             


Leu Asn Asp Leu Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr 
    130                 135                 140                 


Cys Trp Asn Lys Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly 
145                 150                 155                 160 


Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu 
                165                 170                 175     


Glu Arg Glu Thr Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu 
            180                 185                 190         


Gly Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        195                 200                 205             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
    210                 215                 220                 


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
225                 230                 235                 240 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
                245                 250                 255     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            260                 265                 270         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
        275                 280                 285             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    290                 295                 300                 


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
305                 310                 315                 320 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                325                 330                 335     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            340                 345                 350         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
        355                 360                 365             


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    370                 375                 380                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
385                 390                 395                 400 


Lys 
    


<210>  26
<211>  397
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human IL-7 fused hyFc

<400>  26

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Arg Asn Thr Gly Arg Gly Gly Glu 
145                 150                 155                 160 


Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln Glu Glu Arg Glu Thr 
                165                 170                 175     


Lys Thr Pro Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Phe Leu 
            180                 185                 190         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        195                 200                 205             


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
    210                 215                 220                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
225                 230                 235                 240 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                245                 250                 255     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            260                 265                 270         


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
        275                 280                 285             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    290                 295                 300                 


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
305                 310                 315                 320 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                325                 330                 335     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            340                 345                 350         


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
        355                 360                 365             


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    370                 375                 380                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
385                 390                 395         


<210>  27
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence of human IL-7 fused nonlytic mouse Fc

<400>  27

Asp Cys Asp Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu 
1               5                   10                  15      


Met Val Ser Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser 
            20                  25                  30          


Asn Cys Leu Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp 
        35                  40                  45              


Ala Asn Lys Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg 
    50                  55                  60                  


Gln Phe Leu Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu 
65                  70                  75                  80  


Lys Val Ser Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val 
                85                  90                  95      


Lys Gly Arg Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser 
            100                 105                 110         


Leu Glu Glu Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu 
        115                 120                 125             


Cys Phe Leu Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys 
    130                 135                 140                 


Ile Leu Met Gly Thr Lys Glu His Ala Ser Ala Glu Pro Arg Gly Pro 
145                 150                 155                 160 


Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Glu 
                165                 170                 175     


Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
            180                 185                 190         


Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
        195                 200                 205             


Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
    210                 215                 220                 


Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
225                 230                 235                 240 


Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
                245                 250                 255     


Gly Lys Ala Phe Ala Cys Ala Val Asn Asn Lys Asp Leu Pro Ala Pro 
            260                 265                 270         


Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
        275                 280                 285             


Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
    290                 295                 300                 


Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
305                 310                 315                 320 


Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
                325                 330                 335     


Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
            340                 345                 350         


Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
        355                 360                 365             


Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
    370                 375                 380                 


Thr Pro Gly Lys Gly Gly Gly Asn Ser Gly Ser 
385                 390                 395 


<210>  28
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of human IL-7

<400>  28
atgttccacg tgagcttcag gtacatcttc ggcctgccac ccctgatcct ggtgctgctg       60

cctgtggcca gctccgactg cgacatcgag ggaaaagacg gcaagcagta cgaaagcgtg      120

ctgatggtgt ccatcgacca gctgctggat tctatgaagg agattgggag taactgcctg      180

aacaatgagt tcaacttctt caaacggcac atttgtgatg ccaacaagga gggaatgttc      240

ctgtttcggg ccgctagaaa actgaggcag ttcctgaaga tgaacagcac cggagacttt      300

gatctgcatc tgctgaaagt gtctgagggc accacaatcc tgctgaactg cactgggcag      360

gtgaaaggaa ggaagcctgc cgctctggga gaggctcagc caaccaagtc actggaggaa      420

aacaaaagcc tgaaggaaca gaagaaactg aatgacctgt gctttctgaa acggctgctg      480

caggagatca aaacatgttg gaacaagatt ctgatgggca caaaggaaca c               531


<210>  29
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(M)

<400>  29
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcatgga ctgcgacatc gagggcaagg acggcaagca gtacgagagc      120

gtgctgatgg tgagcatcga ccagctgctg gacagcatga aggagatcgg cagcaactgc      180

ctgaacaacg agttcaactt cttcaagaga cacatctgcg acgccaacaa ggagggcatg      240

ttcctgttca gagccgccag aaagctgaga cagttcctga agatgaacag caccggcgac      300

ttcgacctgc acctgctgaa ggtgagcgag ggcacaacca tcctgctgaa ctgcaccggc      360

caggtgaagg gcagaaagcc cgccgccctg ggcgaggccc agcccaccaa gagcctggag      420

gagaacaaga gcctgaagga gcagaagaag ctgaacgacc tgtgcttcct gaagagactg      480

ctgcaggaga tcaagacctg ctggaacaag atcctgatgg gcaccaagga gcac            534


<210>  30
<211>  537
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(MM)

<400>  30
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcatgat ggactgcgac atcgagggca aggacggcaa gcagtacgag      120

agcgtgctga tggtgagcat cgaccagctg ctggacagca tgaaggagat cggcagcaac      180

tgcctgaaca acgagttcaa cttcttcaag agacacatct gcgacgccaa caaggagggc      240

atgttcctgt tcagagccgc cagaaagctg agacagttcc tgaagatgaa cagcaccggc      300

gacttcgacc tgcacctgct gaaggtgagc gagggcacaa ccatcctgct gaactgcacc      360

ggccaggtga agggcagaaa gcccgccgcc ctgggcgagg cccagcccac caagagcctg      420

gaggagaaca agagcctgaa ggagcagaag aagctgaacg acctgtgctt cctgaagaga      480

ctgctgcagg agatcaagac ctgctggaac aagatcctga tgggcaccaa ggagcac         537


<210>  31
<211>  540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(MMM)

<400>  31
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcatgat gatggactgc gacatcgagg gcaaggacgg caagcagtac      120

gagagcgtgc tgatggtgag catcgaccag ctgctggaca gcatgaagga gatcggcagc      180

aactgcctga acaacgagtt caacttcttc aagagacaca tctgcgacgc caacaaggag      240

ggcatgttcc tgttcagagc cgccagaaag ctgagacagt tcctgaagat gaacagcacc      300

ggcgacttcg acctgcacct gctgaaggtg agcgagggca caaccatcct gctgaactgc      360

accggccagg tgaagggcag aaagcccgcc gccctgggcg aggcccagcc caccaagagc      420

ctggaggaga acaagagcct gaaggagcag aagaagctga acgacctgtg cttcctgaag      480

agactgctgc aggagatcaa gacctgctgg aacaagatcc tgatgggcac caaggagcac      540


<210>  32
<211>  540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(MGM)

<400>  32
atgttccacg tgagcttcag gtacatcttc ggcctgccac ccctgatcct ggtgctgctg       60

cctgtggcca gctccatggg gatggactgc gacatcgagg gaaaagacgg caagcagtac      120

gaaagcgtgc tgatggtgtc catcgaccag ctgctggatt ctatgaagga gattgggagt      180

aactgcctga acaatgagtt caacttcttc aaacggcaca tttgtgatgc caacaaggag      240

ggaatgttcc tgtttcgggc cgctagaaaa ctgaggcagt tcctgaagat gaacagcacc      300

ggagactttg atctgcatct gctgaaagtg tctgagggca ccacaatcct gctgaactgc      360

actgggcagg tgaaaggaag gaagcctgcc gctctgggag aggctcagcc aaccaagtca      420

ctggaggaaa acaaaagcct gaaggaacag aagaaactga atgacctgtg ctttctgaaa      480

cggctgctgc aggagatcaa aacatgttgg aacaagattc tgatgggcac caaggagcac      540


<210>  33
<211>  540
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(DDD)

<400>  33
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcgacga tgacgactgc gacatcgagg gcaaggacgg caagcagtac      120

gagagcgtgc tgatggtgag catcgaccag ctgctggaca gcatgaagga gatcggcagc      180

aactgcctga acaacgagtt caacttcttc aagagacaca tctgcgacgc caacaaggag      240

ggcatgttcc tgttcagagc cgccagaaag ctgagacagt tcctgaagat gaacagcacc      300

ggcgacttcg acctgcacct gctgaaggtg agcgagggca caaccatcct gctgaactgc      360

accggccagg tgaagggcag aaagcccgcc gccctgggcg aggcccagcc caccaagagc      420

ctggaggaga acaagagcct gaaggagcag aagaagctga acgacctgtg cttcctgaag      480

agactgctgc aggagatcaa gacctgctgg aacaagatcc tgatgggcac caaggagcac      540


<210>  34
<211>  543
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(MMMM)

<400>  34
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcatgat gatgatggac tgcgacatcg agggcaagga cggcaagcag      120

tacgagagcg tgctgatggt gagcatcgac cagctgctgg acagcatgaa ggagatcggc      180

agcaactgcc tgaacaacga gttcaacttc ttcaagagac acatctgcga cgccaacaag      240

gagggcatgt tcctgttcag agccgccaga aagctgagac agttcctgaa gatgaacagc      300

accggcgact tcgacctgca cctgctgaag gtgagcgagg gcacaaccat cctgctgaac      360

tgcaccggcc aggtgaaggg cagaaagccc gccgccctgg gcgaggccca gcccaccaag      420

agcctggagg agaacaagag cctgaaggag cagaagaagc tgaacgacct gtgcttcctg      480

aagagactgc tgcaggagat caagacctgc tggaacaaga tcctgatggg caccaaggag      540

cac                                                                    543


<210>  35
<211>  1284
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(M) fused hyFc

<400>  35
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcatgga ctgcgacatc gagggcaagg acggcaagca gtacgagagc      120

gtgctgatgg tgagcatcga ccagctgctg gacagcatga aggagatcgg cagcaactgc      180

ctgaacaacg agttcaactt cttcaagaga cacatctgcg acgccaacaa ggagggcatg      240

ttcctgttca gagccgccag aaagctgaga cagttcctga agatgaacag caccggcgac      300

ttcgacctgc acctgctgaa ggtgagcgag ggcacaacca tcctgctgaa ctgcaccggc      360

caggtgaagg gcagaaagcc cgccgccctg ggcgaggccc agcccaccaa gagcctggag      420

gagaacaaga gcctgaagga gcagaagaag ctgaacgacc tgtgcttcct gaagagactg      480

ctgcaggaga tcaagacctg ctggaacaag atcctgatgg gcaccaagga gcacaggaac      540

acaggcagag gcggcgagga gaagaagaag gagaaggaga aggaggagca ggaggaaaga      600

gagaccaaga cccccgagtg ccccagccac acccagcccc tgggcgtgtt cctgttccct      660

cccaagccca aggacaccct gatgatcagc agaacccccg aggtgacctg cgtggtcgtg      720

gatgtgagcc aggaagatcc cgaagtgcag ttcaactggt acgtggatgg cgtggaagtg      780

cacaacgcca agaccaagcc cagagaagag cagttcaact ccacctacag agtggtgagc      840

gtgctgaccg tgctgcacca ggactggctg aacggcaagg agtacaagtg caaggtgtcc      900

aacaaaggcc tgcccagctc catcgagaag accatcagca aagccaaagg ccagcccaga      960

gaaccccagg tgtacaccct gcctcccagc caggaagaga tgaccaagaa ccaggtgtcc     1020

ctgacctgcc tggtgaaagg cttctacccc agcgacatcg ccgtggagtg ggaaagcaac     1080

ggccagcccg agaacaatta caagacaacc cctcccgtgc tggatagcga tggcagcttc     1140

tttctgtaca gcagactgac cgtggacaag agcagatggc aggaaggcaa cgtgttcagc     1200

tgcagcgtga tgcacgaagc cctgcacaac cactacaccc agaagagcct gtccctgagc     1260

ctgggcaagt gactcgagtc taga                                            1284


<210>  36
<211>  1272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(MM) fused hyFc

<400>  36
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcatgat ggactgcgac atcgagggca aggacggcaa gcagtacgag      120

agcgtgctga tggtgagcat cgaccagctg ctggacagca tgaaggagat cggcagcaac      180

tgcctgaaca acgagttcaa cttcttcaag agacacatct gcgacgccaa caaggagggc      240

atgttcctgt tcagagccgc cagaaagctg agacagttcc tgaagatgaa cagcaccggc      300

gacttcgacc tgcacctgct gaaggtgagc gagggcacaa ccatcctgct gaactgcacc      360

ggccaggtga agggcagaaa gcccgccgcc ctgggcgagg cccagcccac caagagcctg      420

gaggagaaca agagcctgaa ggagcagaag aagctgaacg acctgtgctt cctgaagaga      480

ctgctgcagg agatcaagac ctgctggaac aagatcctga tgggcaccaa ggagcacagg      540

aacacaggca gaggcggcga ggagaagaag aaggagaagg agaaggagga gcaggaggaa      600

agagagacca agacccccga gtgccccagc cacacccagc ccctgggcgt gttcctgttc      660

cctcccaagc ccaaggacac cctgatgatc agcagaaccc ccgaggtgac ctgcgtggtc      720

gtggatgtga gccaggaaga tcccgaagtg cagttcaact ggtacgtgga tggcgtggaa      780

gtgcacaacg ccaagaccaa gcccagagaa gagcagttca actccaccta cagagtggtg      840

agcgtgctga ccgtgctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtg      900

tccaacaaag gcctgcccag ctccatcgag aagaccatca gcaaagccaa aggccagccc      960

agagaacccc aggtgtacac cctgcctccc agccaggaag agatgaccaa gaaccaggtg     1020

tccctgacct gcctggtgaa aggcttctac cccagcgaca tcgccgtgga gtgggaaagc     1080

aacggccagc ccgagaacaa ttacaagaca acccctcccg tgctggatag cgatggcagc     1140

ttctttctgt acagcagact gaccgtggac aagagcagat ggcaggaagg caacgtgttc     1200

agctgcagcg tgatgcacga agccctgcac aaccactaca cccagaagag cctgtccctg     1260

agcctgggca ag                                                         1272


<210>  37
<211>  1275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(MMM) fused hyFc

<400>  37
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcatgat gatggactgc gacatcgagg gcaaggacgg caagcagtac      120

gagagcgtgc tgatggtgag catcgaccag ctgctggaca gcatgaagga gatcggcagc      180

aactgcctga acaacgagtt caacttcttc aagagacaca tctgcgacgc caacaaggag      240

ggcatgttcc tgttcagagc cgccagaaag ctgagacagt tcctgaagat gaacagcacc      300

ggcgacttcg acctgcacct gctgaaggtg agcgagggca caaccatcct gctgaactgc      360

accggccagg tgaagggcag aaagcccgcc gccctgggcg aggcccagcc caccaagagc      420

ctggaggaga acaagagcct gaaggagcag aagaagctga acgacctgtg cttcctgaag      480

agactgctgc aggagatcaa gacctgctgg aacaagatcc tgatgggcac caaggagcac      540

aggaacacag gcagaggcgg cgaggagaag aagaaggaga aggagaagga ggagcaggag      600

gaaagagaga ccaagacccc cgagtgcccc agccacaccc agcccctggg cgtgttcctg      660

ttccctccca agcccaagga caccctgatg atcagcagaa cccccgaggt gacctgcgtg      720

gtcgtggatg tgagccagga agatcccgaa gtgcagttca actggtacgt ggatggcgtg      780

gaagtgcaca acgccaagac caagcccaga gaagagcagt tcaactccac ctacagagtg      840

gtgagcgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      900

gtgtccaaca aaggcctgcc cagctccatc gagaagacca tcagcaaagc caaaggccag      960

cccagagaac cccaggtgta caccctgcct cccagccagg aagagatgac caagaaccag     1020

gtgtccctga cctgcctggt gaaaggcttc taccccagcg acatcgccgt ggagtgggaa     1080

agcaacggcc agcccgagaa caattacaag acaacccctc ccgtgctgga tagcgatggc     1140

agcttctttc tgtacagcag actgaccgtg gacaagagca gatggcagga aggcaacgtg     1200

ttcagctgca gcgtgatgca cgaagccctg cacaaccact acacccagaa gagcctgtcc     1260

ctgagcctgg gcaag                                                      1275


<210>  38
<211>  1275
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(MGM) fused hyFc

<400>  38
atgttccacg tgagcttcag gtacatcttc ggcctgccac ccctgatcct ggtgctgctg       60

cctgtggcca gctccatggg gatggactgc gacatcgagg gaaaagacgg caagcagtac      120

gaaagcgtgc tgatggtgtc catcgaccag ctgctggatt ctatgaagga gattgggagt      180

aactgcctga acaatgagtt caacttcttc aaacggcaca tttgtgatgc caacaaggag      240

ggaatgttcc tgtttcgggc cgctagaaaa ctgaggcagt tcctgaagat gaacagcacc      300

ggagactttg atctgcatct gctgaaagtg tctgagggca ccacaatcct gctgaactgc      360

actgggcagg tgaaaggaag gaagcctgcc gctctgggag aggctcagcc aaccaagtca      420

ctggaggaaa acaaaagcct gaaggaacag aagaaactga atgacctgtg ctttctgaaa      480

cggctgctgc aggagatcaa aacatgttgg aacaagattc tgatgggcac aaaggaacac      540

cgcaatactg ggcggggcgg ggaggaaaag aaaaaggaga aggaaaagga ggaacaggag      600

gaaagagaga ctaagacccc agaatgtccc agccatactc agcccctggg ggtgttcctg      660

tttcccccta aacctaagga taccctgatg atcagcagga cacccgaggt gacctgcgtg      720

gtcgtggatg tgagccagga agatcccgaa gtgcagttca actggtacgt ggatggcgtg      780

gaagtgcaca acgccaagac caagcccaga gaagagcagt tcaactccac ctacagagtg      840

gtgagcgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaggagta caagtgcaag      900

gtgtccaaca aaggcctgcc cagctccatc gagaagacca tcagcaaagc caaaggccag      960

cccagagaac cccaggtgta caccctgcct cccagccagg aagagatgac caagaaccag     1020

gtgtccctga cctgcctggt gaaaggcttc taccccagcg acatcgccgt ggagtgggaa     1080

agcaacggcc agcccgagaa caattacaag acaacccctc ccgtgctgga tagcgatggc     1140

agcttctttc tgtacagcag actgaccgtg gacaagagca gatggcagga aggcaacgtg     1200

ttcagctgca gcgtgatgca cgaagccctg cacaaccact acacccagaa gagcctgtcc     1260

ctgagcctgg gcaag                                                      1275


<210>  39
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of modified IL-7(MMMM) fused hyFc

<400>  39
atgttccacg tgagcttcag atacatcttc ggcctgcccc ccctgatcct ggtgctgctg       60

cccgtggcca gcagcatgat gatgatggac tgcgacatcg agggcaagga cggcaagcag      120

tacgagagcg tgctgatggt gagcatcgac cagctgctgg acagcatgaa ggagatcggc      180

agcaactgcc tgaacaacga gttcaacttc ttcaagagac acatctgcga cgccaacaag      240

gagggcatgt tcctgttcag agccgccaga aagctgagac agttcctgaa gatgaacagc      300

accggcgact tcgacctgca cctgctgaag gtgagcgagg gcacaaccat cctgctgaac      360

tgcaccggcc aggtgaaggg cagaaagccc gccgccctgg gcgaggccca gcccaccaag      420

agcctggagg agaacaagag cctgaaggag cagaagaagc tgaacgacct gtgcttcctg      480

aagagactgc tgcaggagat caagacctgc tggaacaaga tcctgatggg caccaaggag      540

cacaggaaca caggcagagg cggcgaggag aagaagaagg agaaggagaa ggaggagcag      600

gaggaaagag agaccaagac ccccgagtgc cccagccaca cccagcccct gggcgtgttc      660

ctgttccctc ccaagcccaa ggacaccctg atgatcagca gaacccccga ggtgacctgc      720

gtggtcgtgg atgtgagcca ggaagatccc gaagtgcagt tcaactggta cgtggatggc      780

gtggaagtgc acaacgccaa gaccaagccc agagaagagc agttcaactc cacctacaga      840

gtggtgagcg tgctgaccgt gctgcaccag gactggctga acggcaagga gtacaagtgc      900

aaggtgtcca acaaaggcct gcccagctcc atcgagaaga ccatcagcaa agccaaaggc      960

cagcccagag aaccccaggt gtacaccctg cctcccagcc aggaagagat gaccaagaac     1020

caggtgtccc tgacctgcct ggtgaaaggc ttctacccca gcgacatcgc cgtggagtgg     1080

gaaagcaacg gccagcccga gaacaattac aagacaaccc ctcccgtgct ggatagcgat     1140

ggcagcttct ttctgtacag cagactgacc gtggacaaga gcagatggca ggaaggcaac     1200

gtgttcagct gcagcgtgat gcacgaagcc ctgcacaacc actacaccca gaagagcctg     1260

tccctgagcc tgggcaag                                                   1278


<210>  40
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  40

Met Met Met Met 
1               


<210>  41
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  41

Met Gly Gly Met 
1               


<210>  42
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  42

Met Met Gly Gly 
1               


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  43

Gly Gly Met Met 
1               


<210>  44
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  44

Met Gly Met Gly 
1               


<210>  45
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  45

Gly Met Met Gly 
1               


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  46

Gly Gly Gly Met 
1               


<210>  47
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  47

Met Gly Gly Gly 
1               


<210>  48
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  48

Gly Met Gly Gly 
1               


<210>  49
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  49

Gly Gly Met Gly 
1               


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  50

Gly Gly Met Met Met 
1               5   


<210>  51
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  51

Gly Gly Gly Met Met 
1               5   


<210>  52
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  52

Gly Gly Gly Gly Met 
1               5   


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  53

Met Gly Met Met Met 
1               5   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  54

Met Gly Gly Met Met 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  55

Met Gly Gly Gly Met 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  56

Met Met Gly Met Met 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  57

Met Met Gly Gly Met 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  58

Met Met Gly Gly Gly 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  59

Met Met Met Gly Met 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  60

Met Gly Met Gly Met 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  61

Gly Met Gly Met Gly 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  62

Gly Met Met Met Gly 
1               5   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  63

Gly Gly Met Gly Met 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  64

Gly Gly Met Met Gly 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  65

Gly Met Met Gly Met 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  66

Met Gly Met Met Gly 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  67

Gly Met Gly Gly Met 
1               5   


<210>  68
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  68

Met Met Gly Met Gly 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  69

Gly Met Met Gly Gly 
1               5   


<210>  70
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  70

Gly Met Gly Gly Gly 
1               5   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  71

Gly Gly Met Gly Gly 
1               5   


<210>  72
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic oligopeptide fragment

<400>  72

Gly Gly Gly Gly Gly 
1               5   



