                         SEQUENCE LISTING

<110>  Regents of the University of Minnesota
 
<120>  LIVE CELL ASSAY FOR PROTEASE INHIBITION

<130>  09531-0478WO1

<150>  US 63/108,611
<151>  2020-11-02

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  663
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  1

Met Gly Ser Ser Lys Ser Lys Pro Lys Asp Gly Gly Gly Gly Ser Ser 
1               5                   10                  15      


Ile Thr Ser Ala Val Leu Gln Ser Gly Phe Arg Lys Met Ala Phe Pro 
            20                  25                  30          


Ser Gly Lys Val Glu Gly Cys Met Val Gln Val Thr Cys Gly Thr Thr 
        35                  40                  45              


Thr Leu Asn Gly Leu Trp Leu Asp Asp Val Val Tyr Cys Pro Arg His 
    50                  55                  60                  


Val Ile Cys Thr Ser Glu Asp Met Leu Asn Pro Asn Tyr Glu Asp Leu 
65                  70                  75                  80  


Leu Ile Arg Lys Ser Asn His Asn Phe Leu Val Gln Ala Gly Asn Val 
                85                  90                  95      


Gln Leu Arg Val Ile Gly His Ser Met Gln Asn Cys Val Leu Lys Leu 
            100                 105                 110         


Lys Val Asp Thr Ala Asn Pro Lys Thr Pro Lys Tyr Lys Phe Val Arg 
        115                 120                 125             


Ile Gln Pro Gly Gln Thr Phe Ser Val Leu Ala Cys Tyr Asn Gly Ser 
    130                 135                 140                 


Pro Ser Gly Val Tyr Gln Cys Ala Met Arg Pro Asn Phe Thr Ile Lys 
145                 150                 155                 160 


Gly Ser Phe Leu Asn Gly Ser Cys Gly Ser Val Gly Phe Asn Ile Asp 
                165                 170                 175     


Tyr Asp Cys Val Ser Phe Cys Tyr Met His His Met Glu Leu Pro Thr 
            180                 185                 190         


Gly Val His Ala Gly Thr Asp Leu Glu Gly Asn Phe Tyr Gly Pro Phe 
        195                 200                 205             


Val Asp Arg Gln Thr Ala Gln Ala Ala Gly Thr Asp Thr Thr Ile Thr 
    210                 215                 220                 


Val Asn Val Leu Ala Trp Leu Tyr Ala Ala Val Ile Asn Gly Asp Arg 
225                 230                 235                 240 


Trp Phe Leu Asn Arg Phe Thr Thr Thr Leu Asn Asp Phe Asn Leu Val 
                245                 250                 255     


Ala Met Lys Tyr Asn Tyr Glu Pro Leu Thr Gln Asp His Val Asp Ile 
            260                 265                 270         


Leu Gly Pro Leu Ser Ala Gln Thr Gly Ile Ala Val Leu Asp Met Cys 
        275                 280                 285             


Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly Met Asn Gly Arg Thr Ile 
    290                 295                 300                 


Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe Thr Pro Phe Asp Val Val 
305                 310                 315                 320 


Arg Gln Cys Ser Gly Val Thr Phe Gln Ser Ala Val Lys Arg Thr Ile 
                325                 330                 335     


Lys Gly Thr Gly Ser Gly Gly Ser Gly Gly Met Glu Pro Val Asp Pro 
            340                 345                 350         


Arg Leu Glu Pro Trp Lys His Pro Gly Ser Gln Pro Lys Thr Ala Cys 
        355                 360                 365             


Thr Asn Cys Tyr Cys Lys Lys Cys Cys Phe His Cys Gln Val Cys Phe 
    370                 375                 380                 


Ile Thr Lys Ala Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg Arg Gln 
385                 390                 395                 400 


Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr His Gln Val Ser Leu Ser 
                405                 410                 415     


Lys Gln Pro Gly Ser Ile Ala Thr Met Val Ser Lys Gly Glu Glu Leu 
            420                 425                 430         


Phe Thr Gly Val Val Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn 
        435                 440                 445             


Gly His Lys Phe Ser Val Ser Gly Glu Gly Glu Gly Asp Ala Thr Tyr 
    450                 455                 460                 


Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val 
465                 470                 475                 480 


Pro Trp Pro Thr Leu Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe 
                485                 490                 495     


Ser Arg Tyr Pro Asp His Met Lys Gln His Asp Phe Phe Lys Ser Ala 
            500                 505                 510         


Met Pro Glu Gly Tyr Val Gln Glu Arg Thr Ile Phe Phe Lys Asp Asp 
        515                 520                 525             


Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys Phe Glu Gly Asp Thr Leu 
    530                 535                 540                 


Val Asn Arg Ile Glu Leu Lys Gly Ile Asp Phe Lys Glu Asp Gly Asn 
545                 550                 555                 560 


Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr Asn Ser His Asn Val Tyr 
                565                 570                 575     


Ile Met Ala Asp Lys Gln Lys Asn Gly Ile Lys Val Asn Phe Lys Ile 
            580                 585                 590         


Arg His Asn Ile Glu Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln 
        595                 600                 605             


Gln Asn Thr Pro Ile Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His 
    610                 615                 620                 


Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys Asp Pro Asn Glu Lys Arg 
625                 630                 635                 640 


Asp His Met Val Leu Leu Glu Phe Val Thr Ala Ala Gly Ile Thr Leu 
                645                 650                 655     


Gly Met Asp Glu Leu Tyr Lys 
            660             


<210>  2
<211>  2013
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  2
aagcttgcca ccatgggcag cagtaagagt aaaccgaaag atggaggcgg tgggtcatct       60

atcacctcag ctgttttgca gtctggtttt aggaaaatgg cgttccccag cggtaaagtt      120

gaaggatgta tggtccaagt aacctgtggt accactaccc ttaatgggct ttggttggac      180

gacgtagtct actgcccccg acacgtaatc tgcactagtg aggatatgct taatcccaat      240

tacgaagacc ttttgattcg gaaatccaat cacaacttcc tggtccaagc gggcaacgtc      300

caactcaggg ttattggaca tagtatgcag aattgcgtac tgaagctcaa agtcgatact      360

gcaaacccca agacgcccaa gtataaattc gtccgaatcc aaccaggcca aacattttcc      420

gtattggctt gctataatgg aagccccagc ggtgtctacc aatgtgcaat gagaccaaac      480

tttacgataa agggttcatt tctgaacggc tcttgcggtt ccgttggttt taacatcgac      540

tatgactgtg tatccttttg ctacatgcac catatggaac tccctaccgg tgtccacgcc      600

ggtacagatc tggaaggaaa tttctacggt ccgttcgttg accggcaaac cgcgcaagcg      660

gctggaaccg acacaacgat tacagtgaat gtgctcgcgt ggctgtacgc agcagtcata      720

aacggagaca ggtggtttct gaaccgattt acgacgactc tcaatgactt caaccttgtt      780

gcgatgaagt acaattacga gccactcacc caggaccatg ttgatatcct gggtcccctc      840

agtgcccaga cagggatcgc agttctcgat atgtgcgcgt cactgaagga gcttctccaa      900

aatggaatga atgggcggac catacttggt tccgcactcc tcgaagatga atttactcca      960

tttgacgtgg tcagacaatg cagtggggtc actttccaga gtgcagtgaa aagaacaatc     1020

aagggtaccg ggtcaggggg cagcggaggg atggagccag tagatcctag actagagccc     1080

tggaagcatc caggaagtca gcctaaaact gcttgtacca attgctattg taaaaagtgt     1140

tgctttcatt gccaagtttg tttcataaca aaagccttag gcatctccta tggcaggaag     1200

aagcggagac agcgacgaag acctcctcaa ggcagtcaga ctcatcaagt ttctctatca     1260

aagcagccgg gatccatcgc caccatggtg agcaagggcg aggagctgtt caccggggtg     1320

gtgcccatcc tggtcgagct ggacggcgac gtaaacggcc acaagttcag cgtgtccggc     1380

gagggcgagg gcgatgccac ctacggcaag ctgaccctga agttcatctg caccaccggc     1440

aagctgcccg tgccctggcc caccctcgtg accaccctga cctacggcgt gcagtgcttc     1500

agccgctacc ccgaccacat gaagcagcac gacttcttca agtccgccat gcccgaaggc     1560

tacgtccagg agcgcaccat cttcttcaag gacgacggca actacaagac ccgcgccgag     1620

gtgaagttcg agggcgacac cctggtgaac cgcatcgagc tgaagggcat cgacttcaag     1680

gaggacggca acatcctggg gcacaagctg gagtacaact acaacagcca caacgtctat     1740

atcatggccg acaagcagaa gaacggcatc aaggtgaact tcaagatccg ccacaacatc     1800

gaggacggca gcgtgcagct cgccgaccac taccagcaga acacccccat cggcgacggc     1860

cccgtgctgc tgcccgacaa ccactacctg agcacccagt ccgccctgag caaagacccc     1920

aacgagaagc gcgatcacat ggtcctgctg gagttcgtga ccgccgccgg gatcactctc     1980

ggcatggacg agctgtacaa gtaaagcggc cgc                                  2013


<210>  3
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  3
gtgggtcatc tatcacctca gctgttttgc agtctggttt taggaaaatg gcgttcc          57


<210>  4
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  4
ccccctgacc cggtaccctt gattgttctt ttcactgcac tctggaaagt gaccccactg       60


<210>  5
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  5
gtgggtcatc tatcacctca gctgttttgg cttctggttt taggaaaatg gcgttcc          57


<210>  6
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  6
ccccctgacc cggtaccctt gattgttctt ttcactgcac tcgcgaaagt gaccccactg       60


<210>  7
<211>  60
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  7
agaacaatca agggtaccgg gtcagggggc agcggaggga tggagccagt agatcctaga       60


<210>  8
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  8
ggtggcgatg gatcccggct gctttgatag agaaacttga tgagtct                     47


<210>  9
<211>  47
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  9
agactcatca agtttctcta tcaaagcagc cgggatccat cgccacc                     47


<210>  10
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  10
gactcgagcg gccgctttac ttgtacagct cgtccat                                37


<210>  11
<211>  72
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  11
aagcttgcca ccatgggcag cagtaagagt aaaccgaaag atggaggcgg tgggtcatct       60

atcacctcag ct                                                           72


<210>  12
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  12

Ala Val Leu Gln Ser Gly Phe Arg 
1               5               


<210>  13
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  13

Val Thr Phe Gln Ser Ala Val Lys 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  14

Ala Thr Val Gln Ser Lys Met Ser 
1               5               


<210>  15
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  15

Ala Thr Leu Gln Ala Ile Ala Ser 
1               5               


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  16

Val Lys Leu Gln Asn Asn Glu Leu 
1               5               


<210>  17
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  17

Val Arg Leu Gln Ala Gly Asn Ala 
1               5               


<210>  18
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  18

Pro Met Leu Gln Ser Ala Asp Ala 
1               5               


<210>  19
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  19

Thr Val Leu Gln Ala Val Gly Ala 
1               5               


<210>  20
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  20

Ala Thr Leu Gln Ala Glu Asn Val 
1               5               


<210>  21
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  21

Thr Arg Leu Gln Ser Leu Glu Asn 
1               5               


<210>  22
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  22

Pro Lys Leu Gln Ser Ser Gln Ala 
1               5               


<210>  23
<211>  973
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  23

Met Gly Ser Ser Lys Ser Lys Pro Lys Asp Gly Gly Gly Gly Ser Ser 
1               5                   10                  15      


Ile Thr Ser Ala Val Leu Gln Ser Gly Phe Arg Lys Met Ala Phe Pro 
            20                  25                  30          


Ser Gly Lys Val Glu Gly Cys Met Val Gln Val Thr Cys Gly Thr Thr 
        35                  40                  45              


Thr Leu Asn Gly Leu Trp Leu Asp Asp Val Val Tyr Cys Pro Arg His 
    50                  55                  60                  


Val Ile Cys Thr Ser Glu Asp Met Leu Asn Pro Asn Tyr Glu Asp Leu 
65                  70                  75                  80  


Leu Ile Arg Lys Ser Asn His Asn Phe Leu Val Gln Ala Gly Asn Val 
                85                  90                  95      


Gln Leu Arg Val Ile Gly His Ser Met Gln Asn Cys Val Leu Lys Leu 
            100                 105                 110         


Lys Val Asp Thr Ala Asn Pro Lys Thr Pro Lys Tyr Lys Phe Val Arg 
        115                 120                 125             


Ile Gln Pro Gly Gln Thr Phe Ser Val Leu Ala Cys Tyr Asn Gly Ser 
    130                 135                 140                 


Pro Ser Gly Val Tyr Gln Cys Ala Met Arg Pro Asn Phe Thr Ile Lys 
145                 150                 155                 160 


Gly Ser Phe Leu Asn Gly Ser Cys Gly Ser Val Gly Phe Asn Ile Asp 
                165                 170                 175     


Tyr Asp Cys Val Ser Phe Cys Tyr Met His His Met Glu Leu Pro Thr 
            180                 185                 190         


Gly Val His Ala Gly Thr Asp Leu Glu Gly Asn Phe Tyr Gly Pro Phe 
        195                 200                 205             


Val Asp Arg Gln Thr Ala Gln Ala Ala Gly Thr Asp Thr Thr Ile Thr 
    210                 215                 220                 


Val Asn Val Leu Ala Trp Leu Tyr Ala Ala Val Ile Asn Gly Asp Arg 
225                 230                 235                 240 


Trp Phe Leu Asn Arg Phe Thr Thr Thr Leu Asn Asp Phe Asn Leu Val 
                245                 250                 255     


Ala Met Lys Tyr Asn Tyr Glu Pro Leu Thr Gln Asp His Val Asp Ile 
            260                 265                 270         


Leu Gly Pro Leu Ser Ala Gln Thr Gly Ile Ala Val Leu Asp Met Cys 
        275                 280                 285             


Ala Ser Leu Lys Glu Leu Leu Gln Asn Gly Met Asn Gly Arg Thr Ile 
    290                 295                 300                 


Leu Gly Ser Ala Leu Leu Glu Asp Glu Phe Thr Pro Phe Asp Val Val 
305                 310                 315                 320 


Arg Gln Cys Ser Gly Val Thr Phe Gln Ser Ala Val Lys Arg Thr Ile 
                325                 330                 335     


Lys Gly Thr Gly Ser Gly Gly Ser Gly Gly Met Glu Pro Val Asp Pro 
            340                 345                 350         


Arg Leu Glu Pro Trp Lys His Pro Gly Ser Gln Pro Lys Thr Ala Cys 
        355                 360                 365             


Thr Asn Cys Tyr Cys Lys Lys Cys Cys Phe His Cys Gln Val Cys Phe 
    370                 375                 380                 


Ile Thr Lys Ala Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg Arg Gln 
385                 390                 395                 400 


Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr His Gln Val Ser Leu Ser 
                405                 410                 415     


Lys Gln Pro Gly Ser Ile Ala Thr Glu Asp Ala Lys Asn Ile Lys Lys 
            420                 425                 430         


Gly Pro Ala Pro Phe Tyr Pro Leu Glu Asp Gly Thr Ala Gly Glu Gln 
        435                 440                 445             


Leu His Lys Ala Met Lys Arg Tyr Ala Leu Val Pro Gly Thr Ile Ala 
    450                 455                 460                 


Phe Thr Asp Ala His Ile Glu Val Asn Ile Thr Tyr Ala Glu Tyr Phe 
465                 470                 475                 480 


Glu Met Ser Val Arg Leu Ala Glu Ala Met Lys Arg Tyr Gly Leu Asn 
                485                 490                 495     


Thr Asn His Arg Ile Val Val Cys Ser Glu Asn Ser Leu Gln Phe Phe 
            500                 505                 510         


Met Pro Val Leu Gly Ala Leu Phe Ile Gly Val Ala Val Ala Pro Ala 
        515                 520                 525             


Asn Asp Ile Tyr Asn Glu Arg Glu Leu Leu Asn Ser Met Asn Ile Ser 
    530                 535                 540                 


Gln Pro Thr Val Val Phe Val Ser Lys Lys Gly Leu Gln Lys Ile Leu 
545                 550                 555                 560 


Asn Val Gln Lys Lys Leu Pro Ile Ile Gln Lys Ile Ile Ile Met Asp 
                565                 570                 575     


Ser Lys Thr Asp Tyr Gln Gly Phe Gln Ser Met Tyr Thr Phe Val Thr 
            580                 585                 590         


Ser His Leu Pro Pro Gly Phe Asn Glu Tyr Asp Phe Val Pro Glu Ser 
        595                 600                 605             


Phe Asp Arg Asp Lys Thr Ile Ala Leu Ile Met Asn Ser Ser Gly Ser 
    610                 615                 620                 


Thr Gly Leu Pro Lys Gly Val Ala Leu Pro His Arg Thr Ala Cys Val 
625                 630                 635                 640 


Arg Phe Ser His Ala Arg Asp Pro Ile Phe Gly Asn Gln Ile Ile Pro 
                645                 650                 655     


Asp Thr Ala Ile Leu Ser Val Val Pro Phe His His Gly Phe Gly Met 
            660                 665                 670         


Phe Thr Thr Leu Gly Tyr Leu Ile Cys Gly Phe Arg Val Val Leu Met 
        675                 680                 685             


Tyr Arg Phe Glu Glu Glu Leu Phe Leu Arg Ser Leu Gln Asp Tyr Lys 
    690                 695                 700                 


Ile Gln Ser Ala Leu Leu Val Pro Thr Leu Phe Ser Phe Phe Ala Lys 
705                 710                 715                 720 


Ser Thr Leu Ile Asp Lys Tyr Asp Leu Ser Asn Leu His Glu Ile Ala 
                725                 730                 735     


Ser Gly Gly Ala Pro Leu Ser Lys Glu Val Gly Glu Ala Val Ala Lys 
            740                 745                 750         


Arg Phe His Leu Pro Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr 
        755                 760                 765             


Thr Ser Ala Ile Leu Ile Thr Pro Glu Gly Asp Asp Lys Pro Gly Ala 
    770                 775                 780                 


Val Gly Lys Val Val Pro Phe Phe Glu Ala Lys Val Val Asp Leu Asp 
785                 790                 795                 800 


Thr Gly Lys Thr Leu Gly Val Asn Gln Arg Gly Glu Leu Cys Val Arg 
                805                 810                 815     


Gly Pro Met Ile Met Ser Gly Tyr Val Asn Asn Pro Glu Ala Thr Asn 
            820                 825                 830         


Ala Leu Ile Asp Lys Asp Gly Trp Leu His Ser Gly Asp Ile Ala Tyr 
        835                 840                 845             


Trp Asp Glu Asp Glu His Phe Phe Ile Val Asp Arg Leu Lys Ser Leu 
    850                 855                 860                 


Ile Lys Tyr Lys Gly Tyr Gln Val Ala Pro Ala Glu Leu Glu Ser Ile 
865                 870                 875                 880 


Leu Leu Gln His Pro Asn Ile Phe Asp Ala Gly Val Ala Gly Leu Pro 
                885                 890                 895     


Asp Asp Asp Ala Gly Glu Leu Pro Ala Ala Val Val Val Leu Glu His 
            900                 905                 910         


Gly Lys Thr Met Thr Glu Lys Glu Ile Val Asp Tyr Val Ala Ser Gln 
        915                 920                 925             


Val Thr Thr Ala Lys Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu 
    930                 935                 940                 


Val Pro Lys Gly Leu Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu 
945                 950                 955                 960 


Ile Leu Ile Lys Ala Lys Lys Gly Gly Lys Ser Lys Leu 
                965                 970             


<210>  24
<211>  2943
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  24
aagcttgcca ccatgggcag cagtaagagt aaaccgaaag atggaggcgg tgggtcatct       60

atcacctcag ctgttttgca gtctggtttt aggaaaatgg cgttccccag cggtaaagtt      120

gaaggatgta tggtccaagt aacctgtggt accactaccc ttaatgggct ttggttggac      180

gacgtagtct actgcccccg acacgtaatc tgcactagtg aggatatgct taatcccaat      240

tacgaagacc ttttgattcg gaaatccaat cacaacttcc tggtccaagc gggcaacgtc      300

caactcaggg ttattggaca tagtatgcag aattgcgtac tgaagctcaa agtcgatact      360

gcaaacccca agacgcccaa gtataaattc gtccgaatcc aaccaggcca aacattttcc      420

gtattggctt gctataatgg aagccccagc ggtgtctacc aatgtgcaat gagaccaaac      480

tttacgataa agggttcatt tctgaacggc tcttgcggtt ccgttggttt taacatcgac      540

tatgactgtg tatccttttg ctacatgcac catatggaac tccctaccgg tgtccacgcc      600

ggtacagatc tggaaggaaa tttctacggt ccgttcgttg accggcaaac cgcgcaagcg      660

gctggaaccg acacaacgat tacagtgaat gtgctcgcgt ggctgtacgc agcagtcata      720

aacggagaca ggtggtttct gaaccgattt acgacgactc tcaatgactt caaccttgtt      780

gcgatgaagt acaattacga gccactcacc caggaccatg ttgatatcct gggtcccctc      840

agtgcccaga cagggatcgc agttctcgat atgtgcgcgt cactgaagga gcttctccaa      900

aatggaatga atgggcggac catacttggt tccgcactcc tcgaagatga atttactcca      960

tttgacgtgg tcagacaatg cagtggggtc actttccaga gtgcagtgaa aagaacaatc     1020

aagggtaccg ggtcaggggg cagcggaggg atggagccag tagatcctag actagagccc     1080

tggaagcatc caggaagtca gcctaaaact gcttgtacca attgctattg taaaaagtgt     1140

tgctttcatt gccaagtttg tttcataaca aaagccttag gcatctccta tggcaggaag     1200

aagcggagac agcgacgaag acctcctcaa ggcagtcaga ctcatcaagt ttctctatca     1260

aagcagccgg gatccatcgc caccgaagac gccaaaaaca taaagaaagg cccggcgcca     1320

ttctatcctc tagaggatgg aaccgctgga gagcaactgc ataaggctat gaagagatac     1380

gccctggttc ctggaacaat tgcttttaca gatgcacata tcgaggtgaa catcacgtac     1440

gcggaatact tcgaaatgtc cgttcggttg gcagaagcta tgaaacgata tgggctgaat     1500

acaaatcaca gaatcgtcgt atgcagtgaa aactctcttc aattctttat gccggtgttg     1560

ggcgcgttat ttatcggagt tgcagttgcg cccgcgaacg acatttataa tgaacgtgaa     1620

ttgctcaaca gtatgaacat ttcgcagcct accgtagtgt ttgtttccaa aaaggggttg     1680

caaaaaattt tgaacgtgca aaaaaaatta ccaataatcc agaaaattat tatcatggat     1740

tctaaaacgg attaccaggg atttcagtcg atgtacacgt tcgtcacatc tcatctacct     1800

cccggtttta atgaatacga ttttgtacca gagtcctttg atcgtgacaa aacaattgca     1860

ctgataatga attcctctgg atctactggg ttacctaagg gtgtggccct tccgcataga     1920

actgcctgcg tcagattctc gcatgccaga gatcctattt ttggcaatca aatcattccg     1980

gatactgcga ttttaagtgt tgttccattc catcacggtt ttggaatgtt tactacactc     2040

ggatatttga tatgtggatt tcgagtcgtc ttaatgtata gatttgaaga agagctgttt     2100

ttacgatccc ttcaggatta caaaattcaa agtgcgttgc tagtaccaac cctattttca     2160

ttcttcgcca aaagcactct gattgacaaa tacgatttat ctaatttaca cgaaattgct     2220

tctgggggcg cacctctttc gaaagaagtc ggggaagcgg ttgcaaaacg cttccatctt     2280

ccagggatac gacaaggata tgggctcact gagactacat cagctattct gattacaccc     2340

gagggggatg ataaaccggg cgcggtcggt aaagttgttc cattttttga agcgaaggtt     2400

gtggatctgg ataccgggaa aacgctgggc gttaatcaga gaggcgaatt atgtgtcaga     2460

ggacctatga ttatgtccgg ttatgtaaac aatccggaag cgaccaacgc cttgattgac     2520

aaggatggat ggctacattc tggagacata gcttactggg acgaagacga acacttcttc     2580

atagttgacc gcttgaagtc tttaattaaa tacaaaggat atcaggtggc ccccgctgaa     2640

ttggaatcga tattgttaca acaccccaac atcttcgacg cgggcgtggc aggtcttccc     2700

gacgatgacg ccggtgaact tcccgccgcc gttgttgttt tggagcacgg aaagacgatg     2760

acggaaaaag agatcgtgga ttacgtcgcc agtcaagtaa caaccgcgaa aaagttgcgc     2820

ggaggagttg tgtttgtgga cgaagtaccg aaaggtctta ccggaaaact cgacgcaaga     2880

aaaatcagag agatcctcat aaaggccaag aagggcggaa agtccaaatt gtaaagcggc     2940

cgc                                                                   2943


<210>  25
<211>  969
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  25

Met Gly Ser Ser Lys Ser Lys Pro Lys Asp Gly Gly Gly Gly Ser Val 
1               5                   10                  15      


Ser Tyr Gly Ser Thr Leu Gln Ala Gly Leu Arg Lys Met Ala Gln Pro 
            20                  25                  30          


Ser Gly Phe Val Glu Lys Cys Val Val Arg Val Cys Tyr Gly Asn Thr 
        35                  40                  45              


Val Leu Asn Gly Leu Trp Leu Gly Asp Ile Val Tyr Cys Pro Arg His 
    50                  55                  60                  


Val Ile Ala Ser Asn Thr Thr Ser Ala Ile Asp Tyr Asp His Glu Tyr 
65                  70                  75                  80  


Ser Ile Met Arg Leu His Asn Phe Ser Ile Ile Ser Gly Thr Ala Phe 
                85                  90                  95      


Leu Gly Val Val Gly Ala Thr Met His Gly Val Thr Leu Lys Ile Lys 
            100                 105                 110         


Val Ser Gln Thr Asn Met His Thr Pro Arg His Ser Phe Arg Thr Leu 
        115                 120                 125             


Lys Ser Gly Glu Gly Phe Asn Ile Leu Ala Cys Tyr Asp Gly Cys Ala 
    130                 135                 140                 


Gln Gly Val Phe Gly Val Asn Met Arg Thr Asn Trp Thr Ile Arg Gly 
145                 150                 155                 160 


Ser Phe Ile Asn Gly Ala Cys Gly Ser Pro Gly Tyr Asn Leu Lys Asn 
                165                 170                 175     


Gly Glu Val Glu Phe Val Tyr Met His Gln Ile Glu Leu Gly Ser Gly 
            180                 185                 190         


Ser His Val Gly Ser Ser Phe Asp Gly Val Met Tyr Gly Gly Phe Glu 
        195                 200                 205             


Asp Gln Pro Asn Leu Gln Val Glu Ser Ala Asn Gln Met Leu Thr Val 
    210                 215                 220                 


Asn Val Val Ala Phe Leu Tyr Ala Ala Ile Leu Asn Gly Cys Thr Trp 
225                 230                 235                 240 


Trp Leu Lys Gly Glu Lys Leu Phe Val Glu His Tyr Asn Glu Trp Ala 
                245                 250                 255     


Gln Ala Asn Gly Phe Thr Ala Met Asn Gly Glu Asp Ala Phe Ser Ile 
            260                 265                 270         


Leu Ala Ala Lys Thr Gly Val Cys Val Glu Arg Leu Leu His Ala Ile 
        275                 280                 285             


Gln Val Leu Asn Asn Gly Phe Gly Gly Lys Gln Ile Leu Gly Tyr Ser 
    290                 295                 300                 


Ser Leu Asn Asp Glu Phe Ser Ile Asn Glu Val Val Lys Gln Met Phe 
305                 310                 315                 320 


Gly Val Asn Leu Gln Ser Gly Lys Thr Thr Ser Met Phe Gly Thr Gly 
                325                 330                 335     


Ser Gly Gly Ser Gly Gly Met Glu Pro Val Asp Pro Arg Leu Glu Pro 
            340                 345                 350         


Trp Lys His Pro Gly Ser Gln Pro Lys Thr Ala Cys Thr Asn Cys Tyr 
        355                 360                 365             


Cys Lys Lys Cys Cys Phe His Cys Gln Val Cys Phe Ile Thr Lys Ala 
    370                 375                 380                 


Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
385                 390                 395                 400 


Pro Gln Gly Ser Gln Thr His Gln Val Ser Leu Ser Lys Gln Pro Gly 
                405                 410                 415     


Ser Ile Ala Thr Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala Pro 
            420                 425                 430         


Phe Tyr Pro Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys Ala 
        435                 440                 445             


Met Lys Arg Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp Ala 
    450                 455                 460                 


His Ile Glu Val Asn Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser Val 
465                 470                 475                 480 


Arg Leu Ala Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His Arg 
                485                 490                 495     


Ile Val Val Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val Leu 
            500                 505                 510         


Gly Ala Leu Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile Tyr 
        515                 520                 525             


Asn Glu Arg Glu Leu Leu Asn Ser Met Asn Ile Ser Gln Pro Thr Val 
    530                 535                 540                 


Val Phe Val Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln Lys 
545                 550                 555                 560 


Lys Leu Pro Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr Asp 
                565                 570                 575     


Tyr Gln Gly Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu Pro 
            580                 585                 590         


Pro Gly Phe Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg Asp 
        595                 600                 605             


Lys Thr Ile Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu Pro 
    610                 615                 620                 


Lys Gly Val Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser His 
625                 630                 635                 640 


Ala Arg Asp Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala Ile 
                645                 650                 655     


Leu Ser Val Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr Leu 
            660                 665                 670         


Gly Tyr Leu Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe Glu 
        675                 680                 685             


Glu Glu Leu Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser Ala 
    690                 695                 700                 


Leu Leu Val Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu Ile 
705                 710                 715                 720 


Asp Lys Tyr Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly Ala 
                725                 730                 735     


Pro Leu Ser Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His Leu 
            740                 745                 750         


Pro Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala Ile 
        755                 760                 765             


Leu Ile Thr Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys Val 
    770                 775                 780                 


Val Pro Phe Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys Thr 
785                 790                 795                 800 


Leu Gly Val Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met Ile 
                805                 810                 815     


Met Ser Gly Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile Asp 
            820                 825                 830         


Lys Asp Gly Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu Asp 
        835                 840                 845             


Glu His Phe Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr Lys 
    850                 855                 860                 


Gly Tyr Gln Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln His 
865                 870                 875                 880 


Pro Asn Ile Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp Ala 
                885                 890                 895     


Gly Glu Leu Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr Met 
            900                 905                 910         


Thr Glu Lys Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr Ala 
        915                 920                 925             


Lys Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys Gly 
    930                 935                 940                 


Leu Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile Lys 
945                 950                 955                 960 


Ala Lys Lys Gly Gly Lys Ser Lys Leu 
                965                 


<210>  26
<211>  2931
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  26
aagcttgcca ccatgggcag cagtaagagt aaaccgaaag atggaggcgg tgggtcagta       60

tcttatggct caacgctcca agccggcttg cgcaagatgg cccaacccag tggctttgtt      120

gagaaatgtg tcgtgcgcgt gtgctatggc aatactgtcc tcaacggtct ctggctcggc      180

gatatcgtgt attgcccgcg gcatgtaata gcatctaata caacttcagc cattgattac      240

gaccatgagt attcaataat gagacttcat aatttcagta ttataagcgg gaccgccttc      300

ctgggcgtcg ttggggctac gatgcatggg gttactctga agataaaggt ttcccaaaca      360

aatatgcaca cgccccgcca ttcttttcgg accctgaagt ctggcgaggg atttaacatt      420

ctggcgtgtt acgacggatg cgcacaagga gttttcggag taaacatgag aacaaattgg      480

actattcggg gctcttttat caacggcgca tgtggtagtc ctggctacaa tcttaaaaat      540

ggggaagtag agtttgttta tatgcaccag atcgagctgg ggtcaggttc ccacgttgga      600

agctcttttg atggggttat gtatggtggc tttgaggacc aacccaattt gcaggtggaa      660

agtgcgaacc aaatgttgac ggtcaatgtc gtagctttcc tctatgccgc tatacttaac      720

ggctgtactt ggtggttgaa aggcgagaaa ctgttcgtgg aacattacaa cgaatgggcg      780

caagccaacg gattcactgc catgaacggc gaggatgctt tctcaatact ggcggccaaa      840

accggggtgt gtgtggaaag actccttcac gcaattcagg tactgaacaa tggcttcggt      900

gggaaacaaa tcttgggata tagcagcctt aatgatgaat tctcaatcaa cgaggtcgtc      960

aaacaaatgt ttggagtgaa cctccaatct ggtaagacta catccatgtt tggtaccggg     1020

tcagggggca gcggagggat ggagccagta gatcctagac tagagccctg gaagcatcca     1080

ggaagtcagc ctaaaactgc ttgtaccaat tgctattgta aaaagtgttg ctttcattgc     1140

caagtttgtt tcataacaaa agccttaggc atctcctatg gcaggaagaa gcggagacag     1200

cgacgaagac ctcctcaagg cagtcagact catcaagttt ctctatcaaa gcagccggga     1260

tccatcgcca ccgaagacgc caaaaacata aagaaaggcc cggcgccatt ctatcctcta     1320

gaggatggaa ccgctggaga gcaactgcat aaggctatga agagatacgc cctggttcct     1380

ggaacaattg cttttacaga tgcacatatc gaggtgaaca tcacgtacgc ggaatacttc     1440

gaaatgtccg ttcggttggc agaagctatg aaacgatatg ggctgaatac aaatcacaga     1500

atcgtcgtat gcagtgaaaa ctctcttcaa ttctttatgc cggtgttggg cgcgttattt     1560

atcggagttg cagttgcgcc cgcgaacgac atttataatg aacgtgaatt gctcaacagt     1620

atgaacattt cgcagcctac cgtagtgttt gtttccaaaa aggggttgca aaaaattttg     1680

aacgtgcaaa aaaaattacc aataatccag aaaattatta tcatggattc taaaacggat     1740

taccagggat ttcagtcgat gtacacgttc gtcacatctc atctacctcc cggttttaat     1800

gaatacgatt ttgtaccaga gtcctttgat cgtgacaaaa caattgcact gataatgaat     1860

tcctctggat ctactgggtt acctaagggt gtggcccttc cgcatagaac tgcctgcgtc     1920

agattctcgc atgccagaga tcctattttt ggcaatcaaa tcattccgga tactgcgatt     1980

ttaagtgttg ttccattcca tcacggtttt ggaatgttta ctacactcgg atatttgata     2040

tgtggatttc gagtcgtctt aatgtataga tttgaagaag agctgttttt acgatccctt     2100

caggattaca aaattcaaag tgcgttgcta gtaccaaccc tattttcatt cttcgccaaa     2160

agcactctga ttgacaaata cgatttatct aatttacacg aaattgcttc tgggggcgca     2220

cctctttcga aagaagtcgg ggaagcggtt gcaaaacgct tccatcttcc agggatacga     2280

caaggatatg ggctcactga gactacatca gctattctga ttacacccga gggggatgat     2340

aaaccgggcg cggtcggtaa agttgttcca ttttttgaag cgaaggttgt ggatctggat     2400

accgggaaaa cgctgggcgt taatcagaga ggcgaattat gtgtcagagg acctatgatt     2460

atgtccggtt atgtaaacaa tccggaagcg accaacgcct tgattgacaa ggatggatgg     2520

ctacattctg gagacatagc ttactgggac gaagacgaac acttcttcat agttgaccgc     2580

ttgaagtctt taattaaata caaaggatat caggtggccc ccgctgaatt ggaatcgata     2640

ttgttacaac accccaacat cttcgacgcg ggcgtggcag gtcttcccga cgatgacgcc     2700

ggtgaacttc ccgccgccgt tgttgttttg gagcacggaa agacgatgac ggaaaaagag     2760

atcgtggatt acgtcgccag tcaagtaaca accgcgaaaa agttgcgcgg aggagttgtg     2820

tttgtggacg aagtaccgaa aggtcttacc ggaaaactcg acgcaagaaa aatcagagag     2880

atcctcataa aggccaagaa gggcggaaag tccaaattgt aaagcggccg c              2931


<210>  27
<211>  970
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  27

Met Gly Ser Ser Lys Ser Lys Pro Lys Asp Gly Gly Gly Gly Ser Ile 
1               5                   10                  15      


Ser Tyr Asn Ser Thr Leu Gln Ser Gly Leu Lys Lys Met Ala Gln Pro 
            20                  25                  30          


Ser Gly Cys Val Glu Arg Cys Val Val Arg Val Cys Tyr Gly Ser Thr 
        35                  40                  45              


Val Leu Asn Gly Val Trp Leu Gly Asp Thr Val Thr Cys Pro Arg His 
    50                  55                  60                  


Val Ile Ala Pro Ser Thr Thr Val Leu Ile Asp Tyr Asp His Ala Tyr 
65                  70                  75                  80  


Ser Thr Met Arg Leu His Asn Phe Ser Val Ser His Asn Gly Val Phe 
                85                  90                  95      


Leu Gly Val Val Gly Val Thr Met His Gly Ser Val Leu Arg Ile Lys 
            100                 105                 110         


Val Ser Gln Ser Asn Val His Thr Pro Lys His Val Phe Lys Thr Leu 
        115                 120                 125             


Lys Pro Gly Asp Ser Phe Asn Ile Leu Ala Cys Tyr Glu Gly Ile Ala 
    130                 135                 140                 


Ser Gly Val Phe Gly Val Asn Leu Arg Thr Asn Phe Thr Ile Lys Gly 
145                 150                 155                 160 


Ser Phe Ile Asn Gly Ala Cys Gly Ser Pro Gly Tyr Asn Val Arg Asn 
                165                 170                 175     


Asp Gly Thr Val Glu Phe Cys Tyr Leu His Gln Ile Glu Leu Gly Ser 
            180                 185                 190         


Gly Ala His Val Gly Ser Asp Phe Thr Gly Ser Val Tyr Gly Asn Phe 
        195                 200                 205             


Asp Asp Gln Pro Ser Leu Gln Val Glu Ser Ala Asn Leu Met Leu Ser 
    210                 215                 220                 


Asp Asn Val Val Ala Phe Leu Tyr Ala Ala Leu Leu Asn Gly Cys Arg 
225                 230                 235                 240 


Trp Trp Leu Cys Ser Thr Arg Val Asn Val Asp Gly Phe Asn Glu Trp 
                245                 250                 255     


Ala Met Ala Asn Gly Tyr Thr Ser Val Ser Ser Val Glu Cys Tyr Ser 
            260                 265                 270         


Ile Leu Ala Ala Lys Thr Gly Val Ser Val Glu Gln Leu Leu Ala Ser 
        275                 280                 285             


Ile Gln His Leu His Glu Gly Phe Gly Gly Lys Asn Ile Leu Gly Tyr 
    290                 295                 300                 


Ser Ser Leu Cys Asp Glu Phe Thr Leu Ala Glu Val Val Lys Gln Met 
305                 310                 315                 320 


Tyr Gly Val Asn Leu Gln Ser Gly Lys Val Ile Phe Gly Leu Gly Thr 
                325                 330                 335     


Gly Ser Gly Gly Ser Gly Gly Met Glu Pro Val Asp Pro Arg Leu Glu 
            340                 345                 350         


Pro Trp Lys His Pro Gly Ser Gln Pro Lys Thr Ala Cys Thr Asn Cys 
        355                 360                 365             


Tyr Cys Lys Lys Cys Cys Phe His Cys Gln Val Cys Phe Ile Thr Lys 
    370                 375                 380                 


Ala Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
385                 390                 395                 400 


Pro Pro Gln Gly Ser Gln Thr His Gln Val Ser Leu Ser Lys Gln Pro 
                405                 410                 415     


Gly Ser Ile Ala Thr Glu Asp Ala Lys Asn Ile Lys Lys Gly Pro Ala 
            420                 425                 430         


Pro Phe Tyr Pro Leu Glu Asp Gly Thr Ala Gly Glu Gln Leu His Lys 
        435                 440                 445             


Ala Met Lys Arg Tyr Ala Leu Val Pro Gly Thr Ile Ala Phe Thr Asp 
    450                 455                 460                 


Ala His Ile Glu Val Asn Ile Thr Tyr Ala Glu Tyr Phe Glu Met Ser 
465                 470                 475                 480 


Val Arg Leu Ala Glu Ala Met Lys Arg Tyr Gly Leu Asn Thr Asn His 
                485                 490                 495     


Arg Ile Val Val Cys Ser Glu Asn Ser Leu Gln Phe Phe Met Pro Val 
            500                 505                 510         


Leu Gly Ala Leu Phe Ile Gly Val Ala Val Ala Pro Ala Asn Asp Ile 
        515                 520                 525             


Tyr Asn Glu Arg Glu Leu Leu Asn Ser Met Asn Ile Ser Gln Pro Thr 
    530                 535                 540                 


Val Val Phe Val Ser Lys Lys Gly Leu Gln Lys Ile Leu Asn Val Gln 
545                 550                 555                 560 


Lys Lys Leu Pro Ile Ile Gln Lys Ile Ile Ile Met Asp Ser Lys Thr 
                565                 570                 575     


Asp Tyr Gln Gly Phe Gln Ser Met Tyr Thr Phe Val Thr Ser His Leu 
            580                 585                 590         


Pro Pro Gly Phe Asn Glu Tyr Asp Phe Val Pro Glu Ser Phe Asp Arg 
        595                 600                 605             


Asp Lys Thr Ile Ala Leu Ile Met Asn Ser Ser Gly Ser Thr Gly Leu 
    610                 615                 620                 


Pro Lys Gly Val Ala Leu Pro His Arg Thr Ala Cys Val Arg Phe Ser 
625                 630                 635                 640 


His Ala Arg Asp Pro Ile Phe Gly Asn Gln Ile Ile Pro Asp Thr Ala 
                645                 650                 655     


Ile Leu Ser Val Val Pro Phe His His Gly Phe Gly Met Phe Thr Thr 
            660                 665                 670         


Leu Gly Tyr Leu Ile Cys Gly Phe Arg Val Val Leu Met Tyr Arg Phe 
        675                 680                 685             


Glu Glu Glu Leu Phe Leu Arg Ser Leu Gln Asp Tyr Lys Ile Gln Ser 
    690                 695                 700                 


Ala Leu Leu Val Pro Thr Leu Phe Ser Phe Phe Ala Lys Ser Thr Leu 
705                 710                 715                 720 


Ile Asp Lys Tyr Asp Leu Ser Asn Leu His Glu Ile Ala Ser Gly Gly 
                725                 730                 735     


Ala Pro Leu Ser Lys Glu Val Gly Glu Ala Val Ala Lys Arg Phe His 
            740                 745                 750         


Leu Pro Gly Ile Arg Gln Gly Tyr Gly Leu Thr Glu Thr Thr Ser Ala 
        755                 760                 765             


Ile Leu Ile Thr Pro Glu Gly Asp Asp Lys Pro Gly Ala Val Gly Lys 
    770                 775                 780                 


Val Val Pro Phe Phe Glu Ala Lys Val Val Asp Leu Asp Thr Gly Lys 
785                 790                 795                 800 


Thr Leu Gly Val Asn Gln Arg Gly Glu Leu Cys Val Arg Gly Pro Met 
                805                 810                 815     


Ile Met Ser Gly Tyr Val Asn Asn Pro Glu Ala Thr Asn Ala Leu Ile 
            820                 825                 830         


Asp Lys Asp Gly Trp Leu His Ser Gly Asp Ile Ala Tyr Trp Asp Glu 
        835                 840                 845             


Asp Glu His Phe Phe Ile Val Asp Arg Leu Lys Ser Leu Ile Lys Tyr 
    850                 855                 860                 


Lys Gly Tyr Gln Val Ala Pro Ala Glu Leu Glu Ser Ile Leu Leu Gln 
865                 870                 875                 880 


His Pro Asn Ile Phe Asp Ala Gly Val Ala Gly Leu Pro Asp Asp Asp 
                885                 890                 895     


Ala Gly Glu Leu Pro Ala Ala Val Val Val Leu Glu His Gly Lys Thr 
            900                 905                 910         


Met Thr Glu Lys Glu Ile Val Asp Tyr Val Ala Ser Gln Val Thr Thr 
        915                 920                 925             


Ala Lys Lys Leu Arg Gly Gly Val Val Phe Val Asp Glu Val Pro Lys 
    930                 935                 940                 


Gly Leu Thr Gly Lys Leu Asp Ala Arg Lys Ile Arg Glu Ile Leu Ile 
945                 950                 955                 960 


Lys Ala Lys Lys Gly Gly Lys Ser Lys Leu 
                965                 970 


<210>  28
<211>  2931
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  28
aagcttgcca ccatgggcag cagtaagagt aaaccgaaag atggaggcgg tgggtcagta       60

tcttatggct caacgctcca agccggcttg cgcaagatgg cccaacccag tggctttgtt      120

gagaaatgtg tcgtgcgcgt gtgctatggc aatactgtcc tcaacggtct ctggctcggc      180

gatatcgtgt attgcccgcg gcatgtaata gcatctaata caacttcagc cattgattac      240

gaccatgagt attcaataat gagacttcat aatttcagta ttataagcgg gaccgccttc      300

ctgggcgtcg ttggggctac gatgcatggg gttactctga agataaaggt ttcccaaaca      360

aatatgcaca cgccccgcca ttcttttcgg accctgaagt ctggcgaggg atttaacatt      420

ctggcgtgtt acgacggatg cgcacaagga gttttcggag taaacatgag aacaaattgg      480

actattcggg gctcttttat caacggcgca tgtggtagtc ctggctacaa tcttaaaaat      540

ggggaagtag agtttgttta tatgcaccag atcgagctgg ggtcaggttc ccacgttgga      600

agctcttttg atggggttat gtatggtggc tttgaggacc aacccaattt gcaggtggaa      660

agtgcgaacc aaatgttgac ggtcaatgtc gtagctttcc tctatgccgc tatacttaac      720

ggctgtactt ggtggttgaa aggcgagaaa ctgttcgtgg aacattacaa cgaatgggcg      780

caagccaacg gattcactgc catgaacggc gaggatgctt tctcaatact ggcggccaaa      840

accggggtgt gtgtggaaag actccttcac gcaattcagg tactgaacaa tggcttcggt      900

gggaaacaaa tcttgggata tagcagcctt aatgatgaat tctcaatcaa cgaggtcgtc      960

aaacaaatgt ttggagtgaa cctccaatct ggtaagacta catccatgtt tggtaccggg     1020

tcagggggca gcggagggat ggagccagta gatcctagac tagagccctg gaagcatcca     1080

ggaagtcagc ctaaaactgc ttgtaccaat tgctattgta aaaagtgttg ctttcattgc     1140

caagtttgtt tcataacaaa agccttaggc atctcctatg gcaggaagaa gcggagacag     1200

cgacgaagac ctcctcaagg cagtcagact catcaagttt ctctatcaaa gcagccggga     1260

tccatcgcca ccgaagacgc caaaaacata aagaaaggcc cggcgccatt ctatcctcta     1320

gaggatggaa ccgctggaga gcaactgcat aaggctatga agagatacgc cctggttcct     1380

ggaacaattg cttttacaga tgcacatatc gaggtgaaca tcacgtacgc ggaatacttc     1440

gaaatgtccg ttcggttggc agaagctatg aaacgatatg ggctgaatac aaatcacaga     1500

atcgtcgtat gcagtgaaaa ctctcttcaa ttctttatgc cggtgttggg cgcgttattt     1560

atcggagttg cagttgcgcc cgcgaacgac atttataatg aacgtgaatt gctcaacagt     1620

atgaacattt cgcagcctac cgtagtgttt gtttccaaaa aggggttgca aaaaattttg     1680

aacgtgcaaa aaaaattacc aataatccag aaaattatta tcatggattc taaaacggat     1740

taccagggat ttcagtcgat gtacacgttc gtcacatctc atctacctcc cggttttaat     1800

gaatacgatt ttgtaccaga gtcctttgat cgtgacaaaa caattgcact gataatgaat     1860

tcctctggat ctactgggtt acctaagggt gtggcccttc cgcatagaac tgcctgcgtc     1920

agattctcgc atgccagaga tcctattttt ggcaatcaaa tcattccgga tactgcgatt     1980

ttaagtgttg ttccattcca tcacggtttt ggaatgttta ctacactcgg atatttgata     2040

tgtggatttc gagtcgtctt aatgtataga tttgaagaag agctgttttt acgatccctt     2100

caggattaca aaattcaaag tgcgttgcta gtaccaaccc tattttcatt cttcgccaaa     2160

agcactctga ttgacaaata cgatttatct aatttacacg aaattgcttc tgggggcgca     2220

cctctttcga aagaagtcgg ggaagcggtt gcaaaacgct tccatcttcc agggatacga     2280

caaggatatg ggctcactga gactacatca gctattctga ttacacccga gggggatgat     2340

aaaccgggcg cggtcggtaa agttgttcca ttttttgaag cgaaggttgt ggatctggat     2400

accgggaaaa cgctgggcgt taatcagaga ggcgaattat gtgtcagagg acctatgatt     2460

atgtccggtt atgtaaacaa tccggaagcg accaacgcct tgattgacaa ggatggatgg     2520

ctacattctg gagacatagc ttactgggac gaagacgaac acttcttcat agttgaccgc     2580

ttgaagtctt taattaaata caaaggatat caggtggccc ccgctgaatt ggaatcgata     2640

ttgttacaac accccaacat cttcgacgcg ggcgtggcag gtcttcccga cgatgacgcc     2700

ggtgaacttc ccgccgccgt tgttgttttg gagcacggaa agacgatgac ggaaaaagag     2760

atcgtggatt acgtcgccag tcaagtaaca accgcgaaaa agttgcgcgg aggagttgtg     2820

tttgtggacg aagtaccgaa aggtcttacc ggaaaactcg acgcaagaaa aatcagagag     2880

atcctcataa aggccaagaa gggcggaaag tccaaattgt aaagcggccg c              2931


<210>  29
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  29

Ala Val Leu Gln 
1               


