                         SEQUENCE LISTING

<110>  AMGEN INC.
       DARIS, Kristine Marie
       LAY, Fides Dwinan
 
<120>  OVEREXPRESSION OF INSULIN-LIKE GROWTH FACTOR (IGF) RECEPTOR 
       MUTANTS TO MODULATE IGF SUPPLEMENTATION

<130>  A-2711-WO-PCT

<140>  PCT/US2021/xxxxxx
<141>  2021-11-01

<150>  63/108,084
<151>  2020-10-30

<160>  16    
<170>  PatentIn version 3.5

<210>  1
<211>  3510
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mus musculus IGF1R Del1 mutant

<400>  1
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcgt gtttctctcc       60

gccgcgctct ctctctggcc gacgagtgga tgccacccgg agtgcctggg cagctgccac      120

acaccggacg acaacacaac ctgcgtggcc tgcagacact actactacaa aggcgtgtgt      180

gtgcctgcct gcccgcctgg cacctacagg ttcgagggct ggcgctgtgt ggatcgcgat      240

ttctgcgcca acatccccaa cgctgagagc agtgactcgg atggcttcgt tatccacgac      300

gatgagtgca tgcaggagtg tccctcaggc ttcatccgca acagcaccca gagcatgtac      360

tgtatcccct gcgaaggccc ctgccccaaa gtctgcggcg atgaagagaa gaaaacgaaa      420

accatcgatt cggtgacttc tgctcaaatg ctccaaggat gcaccatcct gaagggcaat      480

ctgcttatta acatccggag aggcaataac attgcctcgg agttggagaa cttcatgggg      540

ctcatcgagg tggtgaccgg ctacgtgaag atccgccatt ctcatgcctt ggtctccttg      600

tccttcctga agaaccttcg tctcatctta ggagaggagc agctggaagg gaactactcc      660

ttctatgtcc tagacaacca gaacttgcag cagctgtggg actggaacca ccggaacctg      720

accgtcaggt ccggaaagat gtactttgct ttcaatccca agctgtgtgt ctccgaaatt      780

taccgcatgg aggaagtgac cggaaccaag ggacgccaga gcaaagggga cataaacacc      840

aggaacaacg gagagcgagc ttcctgtgaa agtgatgttc tccgtttcac ctccaccacg      900

acctggaaga accgaatcat cataacgtgg caccggtacc ggccgccgga ctaccgggat      960

ctcatcagct tcacagttta ctacaaggag gcaccattta aaaacgttac ggaatatgac     1020

gggcaggatg cctgtggctc caacagctgg aacatggtgg atgtagacct gcctccgaac     1080

aaggagggcg agcctggcat tttactgcat gggctgaagc cctggaccca gtatgctgtc     1140

tatgtcaagg ctgtgaccct caccatggtg gaaaacgacc atatccgtgg ggccaaaagt     1200

gaaatcttgt acattcgcac caatgcttca gtcccttcca ttcccctaga tgtcctctca     1260

gcatcaaact cttcctctca gctgattgtg aagtggaatc ctccaactct gcccaatggt     1320

aacttgagtt actacattgt gaggtggcag cggcagcccc aggatggtta cctgtaccgg     1380

cacaactact gctccaaaga caaaataccc atcagaaagt acgccgatgg taccatcgac     1440

gtggaggagg tgacggaaaa tcccaagaca gaagtgtgtg gtggtgataa agggccatgc     1500

tgcgcttgcc ctaaaactga agctgagaag caggctgaga aagaggaggc tgagtaccgt     1560

aaagtctttg agaatttcct tcacaattcc atctttgtgc ccaggcccga aaggaggcgg     1620

agagacgtca tgcaagtggc caacacgacc atgtccagcc gaagcaggaa caccacggta     1680

gctgacacct acaatatcac agacccggag gagttcgaga cagagtaccc tttctttgag     1740

agcagagtgg ataacaagga gaggactgtc atctccaacc tccggccttt cactctgtac     1800

cgcatcgata tccacagctg caaccacgag gctgagaagc tgggctgcag cgcctccaac     1860

ttcgtctttg cgagaaccat gccagcagaa ggagcagatg atatccctgg tccggtgacc     1920

tgggagccaa gacccgaaaa ctccatcttt ttaaagtggc cagaacccga gaaccccaac     1980

ggattgatcc taatgtatga aattaaatac gggtcgcaag tcgaggatca gcgggaatgt     2040

gtgtccagac aggagtacag gaagtacgga ggggccaaac tcaaccgtct aaacccaggg     2100

aactatacag cccggattca ggctacctcc ctctctggga atgggtcatg gacagatcct     2160

gtgttcttct atgtccccgc caaaacgacg tatgagaact tcatgcatct gatcattgct     2220

ctgccggttg ccatcctgct gatcgttggg gggctggtta tcatgctgta tgtcttccat     2280

agaaagagaa ataacagcag gttgggcaat ggagtgctgt atgcttctgt gaaccccgag     2340

tatttcagcg cagctgatgt gtacgtgcct gatgaatggg aggtagctcg agagaagatc     2400

accatgaacc gggagctcgg acaagggtcc tttgggatgg tctatgaagg agtggccaag     2460

ggtgtggtca aggatgaacc cgaaaccaga gtggccatca agacggtaaa cgaggctgca     2520

agtatgcgtg aaagaatcga gtttctcaac gaggcctcgg tgatgaagga gttcaattgt     2580

caccatgtgg tccggttgct gggtgtggta tcccaaggcc agcccaccct ggtcatcatg     2640

gaactaatga cacgcggtga tctcaaaagt tatctccggt ctctgaggcc agaagtggag     2700

cagaataatc tagtcctcat tcctccgagc ttaagcaaga tgatccagat ggctggagag     2760

attgcagatg gcatggccta cctcaatgcc aacaagttcg tccacagaga ccttgctgct     2820

aggaactgca tggtagccga agatttcaca gtcaaaattg gagatttcgg tatgacacga     2880

gacatctacg agacggacta ctaccggaaa ggcgggaagg ggttgctgcc tgtgcgctgg     2940

atgtctcccg agtccctcaa ggatggtgtc ttcactactc attctgatgt ctggtccttc     3000

ggggtcgtcc tctgggagat cgccacgctg gctgagcagc cctaccaggg cttgtccaac     3060

gagcaagttc ttcgtttcgt catggagggt ggccttctgg acaagccgga caactgccct     3120

gatatgctgt ttgaacttat gcgcatgtgc tggcagtata accccaagat gcggccctcc     3180

ttcctggaga tcatcggcag catcaaggat gagatggagc ccagcttcca ggaggtctcc     3240

ttctactaca gcgaggagaa caagcctccc gagccagagg agctggagat ggagcctgag     3300

aacatggaga gcgtcccact ggacccttcg gcctcctcag cctccctgcc tctgcctgaa     3360

agacactcag gacacaaggc tgagaatggc ccgggccctg gcgtgctcgt tctccgcgcc     3420

agttttgatg agagacagcc ttacgctcac atgaacgggg gacgcgccaa cgagagggcc     3480

ttgcctctgc cccagtcctc gacctgctga                                      3510


<210>  2
<211>  1169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mus musculus IGF1R Del1 mutant

<400>  2

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Val Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Cys His 
            20                  25                  30          


Pro Glu Cys Leu Gly Ser Cys His Thr Pro Asp Asp Asn Thr Thr Cys 
        35                  40                  45              


Val Ala Cys Arg His Tyr Tyr Tyr Lys Gly Val Cys Val Pro Ala Cys 
    50                  55                  60                  


Pro Pro Gly Thr Tyr Arg Phe Glu Gly Trp Arg Cys Val Asp Arg Asp 
65                  70                  75                  80  


Phe Cys Ala Asn Ile Pro Asn Ala Glu Ser Ser Asp Ser Asp Gly Phe 
                85                  90                  95      


Val Ile His Asp Asp Glu Cys Met Gln Glu Cys Pro Ser Gly Phe Ile 
            100                 105                 110         


Arg Asn Ser Thr Gln Ser Met Tyr Cys Ile Pro Cys Glu Gly Pro Cys 
        115                 120                 125             


Pro Lys Val Cys Gly Asp Glu Glu Lys Lys Thr Lys Thr Ile Asp Ser 
    130                 135                 140                 


Val Thr Ser Ala Gln Met Leu Gln Gly Cys Thr Ile Leu Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Ile Asn Ile Arg Arg Gly Asn Asn Ile Ala Ser Glu Leu Glu 
                165                 170                 175     


Asn Phe Met Gly Leu Ile Glu Val Val Thr Gly Tyr Val Lys Ile Arg 
            180                 185                 190         


His Ser His Ala Leu Val Ser Leu Ser Phe Leu Lys Asn Leu Arg Leu 
        195                 200                 205             


Ile Leu Gly Glu Glu Gln Leu Glu Gly Asn Tyr Ser Phe Tyr Val Leu 
    210                 215                 220                 


Asp Asn Gln Asn Leu Gln Gln Leu Trp Asp Trp Asn His Arg Asn Leu 
225                 230                 235                 240 


Thr Val Arg Ser Gly Lys Met Tyr Phe Ala Phe Asn Pro Lys Leu Cys 
                245                 250                 255     


Val Ser Glu Ile Tyr Arg Met Glu Glu Val Thr Gly Thr Lys Gly Arg 
            260                 265                 270         


Gln Ser Lys Gly Asp Ile Asn Thr Arg Asn Asn Gly Glu Arg Ala Ser 
        275                 280                 285             


Cys Glu Ser Asp Val Leu Arg Phe Thr Ser Thr Thr Thr Trp Lys Asn 
    290                 295                 300                 


Arg Ile Ile Ile Thr Trp His Arg Tyr Arg Pro Pro Asp Tyr Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Phe Thr Val Tyr Tyr Lys Glu Ala Pro Phe Lys Asn Val 
                325                 330                 335     


Thr Glu Tyr Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Asn Met 
            340                 345                 350         


Val Asp Val Asp Leu Pro Pro Asn Lys Glu Gly Glu Pro Gly Ile Leu 
        355                 360                 365             


Leu His Gly Leu Lys Pro Trp Thr Gln Tyr Ala Val Tyr Val Lys Ala 
    370                 375                 380                 


Val Thr Leu Thr Met Val Glu Asn Asp His Ile Arg Gly Ala Lys Ser 
385                 390                 395                 400 


Glu Ile Leu Tyr Ile Arg Thr Asn Ala Ser Val Pro Ser Ile Pro Leu 
                405                 410                 415     


Asp Val Leu Ser Ala Ser Asn Ser Ser Ser Gln Leu Ile Val Lys Trp 
            420                 425                 430         


Asn Pro Pro Thr Leu Pro Asn Gly Asn Leu Ser Tyr Tyr Ile Val Arg 
        435                 440                 445             


Trp Gln Arg Gln Pro Gln Asp Gly Tyr Leu Tyr Arg His Asn Tyr Cys 
    450                 455                 460                 


Ser Lys Asp Lys Ile Pro Ile Arg Lys Tyr Ala Asp Gly Thr Ile Asp 
465                 470                 475                 480 


Val Glu Glu Val Thr Glu Asn Pro Lys Thr Glu Val Cys Gly Gly Asp 
                485                 490                 495     


Lys Gly Pro Cys Cys Ala Cys Pro Lys Thr Glu Ala Glu Lys Gln Ala 
            500                 505                 510         


Glu Lys Glu Glu Ala Glu Tyr Arg Lys Val Phe Glu Asn Phe Leu His 
        515                 520                 525             


Asn Ser Ile Phe Val Pro Arg Pro Glu Arg Arg Arg Arg Asp Val Met 
    530                 535                 540                 


Gln Val Ala Asn Thr Thr Met Ser Ser Arg Ser Arg Asn Thr Thr Val 
545                 550                 555                 560 


Ala Asp Thr Tyr Asn Ile Thr Asp Pro Glu Glu Phe Glu Thr Glu Tyr 
                565                 570                 575     


Pro Phe Phe Glu Ser Arg Val Asp Asn Lys Glu Arg Thr Val Ile Ser 
            580                 585                 590         


Asn Leu Arg Pro Phe Thr Leu Tyr Arg Ile Asp Ile His Ser Cys Asn 
        595                 600                 605             


His Glu Ala Glu Lys Leu Gly Cys Ser Ala Ser Asn Phe Val Phe Ala 
    610                 615                 620                 


Arg Thr Met Pro Ala Glu Gly Ala Asp Asp Ile Pro Gly Pro Val Thr 
625                 630                 635                 640 


Trp Glu Pro Arg Pro Glu Asn Ser Ile Phe Leu Lys Trp Pro Glu Pro 
                645                 650                 655     


Glu Asn Pro Asn Gly Leu Ile Leu Met Tyr Glu Ile Lys Tyr Gly Ser 
            660                 665                 670         


Gln Val Glu Asp Gln Arg Glu Cys Val Ser Arg Gln Glu Tyr Arg Lys 
        675                 680                 685             


Tyr Gly Gly Ala Lys Leu Asn Arg Leu Asn Pro Gly Asn Tyr Thr Ala 
    690                 695                 700                 


Arg Ile Gln Ala Thr Ser Leu Ser Gly Asn Gly Ser Trp Thr Asp Pro 
705                 710                 715                 720 


Val Phe Phe Tyr Val Pro Ala Lys Thr Thr Tyr Glu Asn Phe Met His 
                725                 730                 735     


Leu Ile Ile Ala Leu Pro Val Ala Ile Leu Leu Ile Val Gly Gly Leu 
            740                 745                 750         


Val Ile Met Leu Tyr Val Phe His Arg Lys Arg Asn Asn Ser Arg Leu 
        755                 760                 765             


Gly Asn Gly Val Leu Tyr Ala Ser Val Asn Pro Glu Tyr Phe Ser Ala 
    770                 775                 780                 


Ala Asp Val Tyr Val Pro Asp Glu Trp Glu Val Ala Arg Glu Lys Ile 
785                 790                 795                 800 


Thr Met Asn Arg Glu Leu Gly Gln Gly Ser Phe Gly Met Val Tyr Glu 
                805                 810                 815     


Gly Val Ala Lys Gly Val Val Lys Asp Glu Pro Glu Thr Arg Val Ala 
            820                 825                 830         


Ile Lys Thr Val Asn Glu Ala Ala Ser Met Arg Glu Arg Ile Glu Phe 
        835                 840                 845             


Leu Asn Glu Ala Ser Val Met Lys Glu Phe Asn Cys His His Val Val 
    850                 855                 860                 


Arg Leu Leu Gly Val Val Ser Gln Gly Gln Pro Thr Leu Val Ile Met 
865                 870                 875                 880 


Glu Leu Met Thr Arg Gly Asp Leu Lys Ser Tyr Leu Arg Ser Leu Arg 
                885                 890                 895     


Pro Glu Val Glu Gln Asn Asn Leu Val Leu Ile Pro Pro Ser Leu Ser 
            900                 905                 910         


Lys Met Ile Gln Met Ala Gly Glu Ile Ala Asp Gly Met Ala Tyr Leu 
        915                 920                 925             


Asn Ala Asn Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met 
    930                 935                 940                 


Val Ala Glu Asp Phe Thr Val Lys Ile Gly Asp Phe Gly Met Thr Arg 
945                 950                 955                 960 


Asp Ile Tyr Glu Thr Asp Tyr Tyr Arg Lys Gly Gly Lys Gly Leu Leu 
                965                 970                 975     


Pro Val Arg Trp Met Ser Pro Glu Ser Leu Lys Asp Gly Val Phe Thr 
            980                 985                 990         


Thr His Ser Asp Val Trp Ser Phe  Gly Val Val Leu Trp  Glu Ile Ala 
        995                 1000                 1005             


Thr Leu  Ala Glu Gln Pro Tyr  Gln Gly Leu Ser Asn  Glu Gln Val 
    1010                 1015                 1020             


Leu Arg  Phe Val Met Glu Gly  Gly Leu Leu Asp Lys  Pro Asp Asn 
    1025                 1030                 1035             


Cys Pro  Asp Met Leu Phe Glu  Leu Met Arg Met Cys  Trp Gln Tyr 
    1040                 1045                 1050             


Asn Pro  Lys Met Arg Pro Ser  Phe Leu Glu Ile Ile  Gly Ser Ile 
    1055                 1060                 1065             


Lys Asp  Glu Met Glu Pro Ser  Phe Gln Glu Val Ser  Phe Tyr Tyr 
    1070                 1075                 1080             


Ser Glu  Glu Asn Lys Pro Pro  Glu Pro Glu Glu Leu  Glu Met Glu 
    1085                 1090                 1095             


Pro Glu  Asn Met Glu Ser Val  Pro Leu Asp Pro Ser  Ala Ser Ser 
    1100                 1105                 1110             


Ala Ser  Leu Pro Leu Pro Glu  Arg His Ser Gly His  Lys Ala Glu 
    1115                 1120                 1125             


Asn Gly  Pro Gly Pro Gly Val  Leu Val Leu Arg Ala  Ser Phe Asp 
    1130                 1135                 1140             


Glu Arg  Gln Pro Tyr Ala His  Met Asn Gly Gly Arg  Ala Asn Glu 
    1145                 1150                 1155             


Arg Ala  Leu Pro Leu Pro Gln  Ser Ser Thr Cys 
    1160                 1165                 


<210>  3
<211>  4110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mus musculus IGF1R H906C mutant

<400>  3
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcgt gtttctctcc       60

gccgcgctct ctctctggcc gacgagtgga gaaatctgtg ggcccggcat tgacatccgc      120

aacgactatc agcagctgaa gcgcctggaa aactgcacgg tgatcgaggg cttcctccac      180

atcctgctca tctccaaggc cgaggactac cgaagctacc gcttccccaa gctcaccgtc      240

atcactgagt acttgctgct cttccgagtc gctggcctcg agagcctggg agacctcttc      300

cccaacctca cagtcatccg tggctggaaa ctcttctaca actacgcact ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tataatctga ggaacattac tcggggggcc      420

atcaggattg agaagaacgc cgacctctgt tacctctcca ccatagactg gtctctcatc      480

ttggatgcgg tgtccaataa ctacattgtg gggaacaagc ccccgaagga atgtggggac      540

ctgtgtccag ggacattgga ggagaagccc atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaatcgc tgccagaaaa tgtgcccaag tgtgtgcggg      660

aagcgagcct gcaccgagaa caacgagtgc tgccacccgg agtgcctggg cagctgccac      720

acaccggacg acaacacaac ctgcgtggcc tgcagacact actactacaa aggcgtgtgt      780

gtgcctgcct gcccgcctgg cacctacagg ttcgagggct ggcgctgtgt ggatcgcgat      840

ttctgcgcca acatccccaa cgctgagagc agtgactcgg atggcttcgt tatccacgac      900

gatgagtgca tgcaggagtg tccctcaggc ttcatccgca acagcaccca gagcatgtac      960

tgtatcccct gcgaaggccc ctgccccaaa gtctgcggcg atgaagagaa gaaaacgaaa     1020

accatcgatt cggtgacttc tgctcaaatg ctccaaggat gcaccatcct gaagggcaat     1080

ctgcttatta acatccggag aggcaataac attgcctcgg agttggagaa cttcatgggg     1140

ctcatcgagg tggtgaccgg ctacgtgaag atccgccatt ctcatgcctt ggtctccttg     1200

tccttcctga agaaccttcg tctcatctta ggagaggagc agctggaagg gaactactcc     1260

ttctatgtcc tagacaacca gaacttgcag cagctgtggg actggaacca ccggaacctg     1320

accgtcaggt ccggaaagat gtactttgct ttcaatccca agctgtgtgt ctccgaaatt     1380

taccgcatgg aggaagtgac cggaaccaag ggacgccaga gcaaagggga cataaacacc     1440

aggaacaacg gagagcgagc ttcctgtgaa agtgatgttc tccgtttcac ctccaccacg     1500

acctggaaga accgaatcat cataacgtgg caccggtacc ggccgccgga ctaccgggat     1560

ctcatcagct tcacagttta ctacaaggag gcaccattta aaaacgttac ggaatatgac     1620

gggcaggatg cctgtggctc caacagctgg aacatggtgg atgtagacct gcctccgaac     1680

aaggagggcg agcctggcat tttactgcat gggctgaagc cctggaccca gtatgctgtc     1740

tatgtcaagg ctgtgaccct caccatggtg gaaaacgacc atatccgtgg ggccaaaagt     1800

gaaatcttgt acattcgcac caatgcttca gtcccttcca ttcccctaga tgtcctctca     1860

gcatcaaact cttcctctca gctgattgtg aagtggaatc ctccaactct gcccaatggt     1920

aacttgagtt actacattgt gaggtggcag cggcagcccc aggatggtta cctgtaccgg     1980

cacaactact gctccaaaga caaaataccc atcagaaagt acgccgatgg taccatcgac     2040

gtggaggagg tgacggaaaa tcccaagaca gaagtgtgtg gtggtgataa agggccatgc     2100

tgcgcttgcc ctaaaactga agctgagaag caggctgaga aggaggaggc tgagtaccgt     2160

aaagtctttg agaatttcct tcacaattcc atctttgtgc ccaggcccga aaggaggcgg     2220

agagacgtca tgcaagtggc caacacgacc atgtccagcc gaagcaggaa caccacggta     2280

gctgacacct acaatatcac agacccggag gagttcgaga cagagtaccc tttctttgag     2340

agcagagtgg ataacaagga gaggactgtc atctccaacc tccggccttt cactctgtac     2400

cgcatcgata tccacagctg caaccacgag gctgagaagc tgggctgcag cgcctccaac     2460

ttcgtctttg cgagaaccat gccagcagaa ggagcagatg atatccctgg tccggtgacc     2520

tgggagccaa gacccgaaaa ctccatcttt ttaaagtggc cagaacccga gaaccccaac     2580

ggattgatcc taatgtatga aattaaatac gggtcgcaag tcgaggatca gcgggaatgt     2640

gtgtccagac aggagtacag gaagtacgga ggggccaaac tcaaccgtct aaacccaggg     2700

aactatacag cccggattca ggctacctcc ctctctggga atgggtcatg gacagatcct     2760

gtgttcttct atgtccccgc caaaacgacg tatgagaact tcatgtgtct gatcattgct     2820

ctgccggttg ccatcctgct gatcgttggg gggctggtta tcatgctgta tgtcttccat     2880

agaaagagaa ataacagcag gttgggcaat ggagtgctgt atgcttctgt gaaccccgag     2940

tatttcagcg cagctgatgt gtacgtgcct gatgaatggg aggtagctcg agagaagatc     3000

accatgaacc gggagctcgg acaagggtcc tttgggatgg tctatgaagg agtggccaag     3060

ggtgtggtca aggatgaacc cgaaaccaga gtggccatca agacggtaaa cgaggctgca     3120

agtatgcgtg aaagaatcga gtttctcaac gaggcctcgg tgatgaagga gttcaattgt     3180

caccatgtgg tccggttgct gggtgtggta tcccaaggcc agcccaccct ggtcatcatg     3240

gaactaatga cacgcggtga tctcaaaagt tatctccggt ctctgaggcc agaagtggag     3300

cagaataatc tagtcctcat tcctccgagc ttaagcaaga tgatccagat ggctggagag     3360

attgcagatg gcatggccta cctcaatgcc aacaagttcg tccacagaga ccttgctgct     3420

aggaactgca tggtagccga agatttcaca gtcaaaattg gagatttcgg tatgacacga     3480

gacatctacg agacggacta ctaccggaaa ggcgggaagg ggttgctgcc tgtgcgctgg     3540

atgtctcccg agtccctcaa ggatggtgtc ttcactactc attctgatgt ctggtccttc     3600

ggggtcgtcc tctgggagat cgccacgctg gctgagcagc cctaccaggg cttgtccaac     3660

gagcaagttc ttcgtttcgt catggagggt ggccttctgg acaagccgga caactgccct     3720

gatatgctgt ttgaacttat gcgcatgtgc tggcagtata accccaagat gcggccctcc     3780

ttcctggaga tcatcggcag catcaaggat gagatggagc ccagcttcca ggaggtctcc     3840

ttctactaca gcgaggagaa caagcctccc gagccagagg agctggagat ggagcctgag     3900

aacatggaga gcgtcccact ggacccttcg gcctcctcag cctccctgcc tctgcctgaa     3960

agacactcag gacacaaggc tgagaatggc ccgggccctg gcgtgctcgt tctccgcgcc     4020

agttttgatg agagacagcc ttacgctcac atgaacgggg gacgcgccaa cgagagggcc     4080

ttgcctctgc cccagtcctc gacctgctga                                      4110


<210>  4
<211>  1369
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mus musculus IGF1R H906C mutant

<400>  4

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Val Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Phe Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Ile Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Leu Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Val Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys His 
225                 230                 235                 240 


Thr Pro Asp Asp Asn Thr Thr Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Lys Gly Val Cys Val Pro Ala Cys Pro Pro Gly Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Pro Asn Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Asp Gly Phe Val Ile His Asp Asp Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Ser Thr Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Gly Asp Glu Glu 
                325                 330                 335     


Lys Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln 
            340                 345                 350         


Gly Cys Thr Ile Leu Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly 
        355                 360                 365             


Asn Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val 
    370                 375                 380                 


Val Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu 
385                 390                 395                 400 


Ser Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu 
                405                 410                 415     


Gly Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu 
            420                 425                 430         


Trp Asp Trp Asn His Arg Asn Leu Thr Val Arg Ser Gly Lys Met Tyr 
        435                 440                 445             


Phe Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu 
    450                 455                 460                 


Glu Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr 
465                 470                 475                 480 


Arg Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu Arg Phe 
                485                 490                 495     


Thr Ser Thr Thr Thr Trp Lys Asn Arg Ile Ile Ile Thr Trp His Arg 
            500                 505                 510         


Tyr Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr 
        515                 520                 525             


Lys Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala 
    530                 535                 540                 


Cys Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn 
545                 550                 555                 560 


Lys Glu Gly Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr 
                565                 570                 575     


Gln Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn 
            580                 585                 590         


Asp His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn 
        595                 600                 605             


Ala Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser 
    610                 615                 620                 


Ser Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Thr Leu Pro Asn Gly 
625                 630                 635                 640 


Asn Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly 
                645                 650                 655     


Tyr Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg 
            660                 665                 670         


Lys Tyr Ala Asp Gly Thr Ile Asp Val Glu Glu Val Thr Glu Asn Pro 
        675                 680                 685             


Lys Thr Glu Val Cys Gly Gly Asp Lys Gly Pro Cys Cys Ala Cys Pro 
    690                 695                 700                 


Lys Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg 
705                 710                 715                 720 


Lys Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro 
                725                 730                 735     


Glu Arg Arg Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser 
            740                 745                 750         


Ser Arg Ser Arg Asn Thr Thr Val Ala Asp Thr Tyr Asn Ile Thr Asp 
        755                 760                 765             


Pro Glu Glu Phe Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp 
    770                 775                 780                 


Asn Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr 
785                 790                 795                 800 


Arg Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys 
                805                 810                 815     


Ser Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala 
            820                 825                 830         


Asp Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser 
        835                 840                 845             


Ile Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu 
    850                 855                 860                 


Met Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys 
865                 870                 875                 880 


Val Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg 
                885                 890                 895     


Leu Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser 
            900                 905                 910         


Gly Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Pro Ala Lys 
        915                 920                 925             


Thr Thr Tyr Glu Asn Phe Met His Leu Ile Ile Ala Leu Pro Val Ala 
    930                 935                 940                 


Ile Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His 
945                 950                 955                 960 


Arg Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser 
                965                 970                 975     


Val Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu 
            980                 985                 990         


Trp Glu Val Ala Arg Glu Lys Ile  Thr Met Asn Arg Glu  Leu Gly Gln 
        995                 1000                 1005             


Gly Ser  Phe Gly Met Val Tyr  Glu Gly Val Ala Lys  Gly Val Val 
    1010                 1015                 1020             


Lys Asp  Glu Pro Glu Thr Arg  Val Ala Ile Lys Thr  Val Asn Glu 
    1025                 1030                 1035             


Ala Ala  Ser Met Arg Glu Arg  Ile Glu Phe Leu Asn  Glu Ala Ser 
    1040                 1045                 1050             


Val Met  Lys Glu Phe Asn Cys  His His Val Val Arg  Leu Leu Gly 
    1055                 1060                 1065             


Val Val  Ser Gln Gly Gln Pro  Thr Leu Val Ile Met  Glu Leu Met 
    1070                 1075                 1080             


Thr Arg  Gly Asp Leu Lys Ser  Tyr Leu Arg Ser Leu  Arg Pro Glu 
    1085                 1090                 1095             


Val Glu  Gln Asn Asn Leu Val  Leu Ile Pro Pro Ser  Leu Ser Lys 
    1100                 1105                 1110             


Met Ile  Gln Met Ala Gly Glu  Ile Ala Asp Gly Met  Ala Tyr Leu 
    1115                 1120                 1125             


Asn Ala  Asn Lys Phe Val His  Arg Asp Leu Ala Ala  Arg Asn Cys 
    1130                 1135                 1140             


Met Val  Ala Glu Asp Phe Thr  Val Lys Ile Gly Asp  Phe Gly Met 
    1145                 1150                 1155             


Thr Arg  Asp Ile Tyr Glu Thr  Asp Tyr Tyr Arg Lys  Gly Gly Lys 
    1160                 1165                 1170             


Gly Leu  Leu Pro Val Arg Trp  Met Ser Pro Glu Ser  Leu Lys Asp 
    1175                 1180                 1185             


Gly Val  Phe Thr Thr His Ser  Asp Val Trp Ser Phe  Gly Val Val 
    1190                 1195                 1200             


Leu Trp  Glu Ile Ala Thr Leu  Ala Glu Gln Pro Tyr  Gln Gly Leu 
    1205                 1210                 1215             


Ser Asn  Glu Gln Val Leu Arg  Phe Val Met Glu Gly  Gly Leu Leu 
    1220                 1225                 1230             


Asp Lys  Pro Asp Asn Cys Pro  Asp Met Leu Phe Glu  Leu Met Arg 
    1235                 1240                 1245             


Met Cys  Trp Gln Tyr Asn Pro  Lys Met Arg Pro Ser  Phe Leu Glu 
    1250                 1255                 1260             


Ile Ile  Gly Ser Ile Lys Asp  Glu Met Glu Pro Ser  Phe Gln Glu 
    1265                 1270                 1275             


Val Ser  Phe Tyr Tyr Ser Glu  Glu Asn Lys Pro Pro  Glu Pro Glu 
    1280                 1285                 1290             


Glu Leu  Glu Met Glu Pro Glu  Asn Met Glu Ser Val  Pro Leu Asp 
    1295                 1300                 1305             


Pro Ser  Ala Ser Ser Ala Ser  Leu Pro Leu Pro Glu  Arg His Ser 
    1310                 1315                 1320             


Gly His  Lys Ala Glu Asn Gly  Pro Gly Pro Gly Val  Leu Val Leu 
    1325                 1330                 1335             


Arg Ala  Ser Phe Asp Glu Arg  Gln Pro Tyr Ala His  Met Asn Gly 
    1340                 1345                 1350             


Gly Arg  Ala Asn Glu Arg Ala  Leu Pro Leu Pro Gln  Ser Ser Thr 
    1355                 1360                 1365             


Cys 
    


<210>  5
<211>  3504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens IGF1R Del1 mutant

<400>  5
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga tgccaccccg agtgcctggg cagctgcagc      120

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      180

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      240

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      300

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      360

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc      420

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg      480

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc      540

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc      600

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc      660

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc      720

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac      780

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg      840

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg      900

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc      960

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1020

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1080

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1140

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1200

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1260

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1320

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1380

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     1440

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     1500

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     1560

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     1620

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     1680

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     1740

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     1800

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     1860

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     1920

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     1980

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2040

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2100

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2160

ttcttctatg tccaggccaa aacaggatat gaaaacttca tccatctgat catcgctctg     2220

cccgtcgctg tcctgttgat cgtgggaggg ttggtgatta tgctgtacgt cttccataga     2280

aagagaaata acagcaggct ggggaatgga gtgctgtatg cctctgtgaa cccggagtac     2340

ttcagcgctg ctgatgtgta cgttcctgat gagtgggagg tggctcggga gaagatcacc     2400

atgagccggg aacttgggca ggggtcgttt gggatggtct atgaaggagt tgccaagggt     2460

gtggtgaaag atgaacctga aaccagagtg gccattaaaa cagtgaacga ggccgcaagc     2520

atgcgtgaga ggattgagtt tctcaacgaa gcttctgtga tgaaggagtt caattgtcac     2580

catgtggtgc gattgctggg tgtggtgtcc caaggccagc caacactggt catcatggaa     2640

ctgatgacac ggggcgatct caaaagttat ctccggtctc tgaggccaga aatggagaat     2700

aatccagtcc tagcacctcc aagcctgagc aagatgattc agatggccgg agagattgca     2760

gacggcatgg catacctcaa cgccaataag ttcgtccaca gagaccttgc tgcccggaat     2820

tgcatggtag ccgaagattt cacagtcaaa atcggagatt ttggtatgac gcgagatatc     2880

tatgagacag actattaccg gaaaggaggg aaagggctgc tgcccgtgcg ctggatgtct     2940

cctgagtccc tcaaggatgg agtcttcacc acttactcgg acgtctggtc cttcggggtc     3000

gtcctctggg agatcgccac actggccgag cagccctacc agggcttgtc caacgagcaa     3060

gtccttcgct tcgtcatgga gggcggcctt ctggacaagc cagacaactg tcctgacatg     3120

ctgtttgaac tgatgcgcat gtgctggcag tataacccca agatgaggcc ttccttcctg     3180

gagatcatca gcagcatcaa agaggagatg gagcctggct tccgggaggt ctccttctac     3240

tacagcgagg agaacaagct gcccgagccg gaggagctgg acctggagcc agagaacatg     3300

gagagcgtcc ccctggaccc ctcggcctcc tcgtcctccc tgccactgcc cgacagacac     3360

tcaggacaca aggccgagaa cggccccggc cctggggtgc tggtcctccg cgccagcttc     3420

gacgagagac agccttacgc ccacatgaac gggggccgca agaacgagcg ggccttgccg     3480

ctgccccagt cttcgacctg ctga                                            3504


<210>  6
<211>  1167
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens IGF1R Del1 mutant

<400>  6

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Cys His 
            20                  25                  30          


Pro Glu Cys Leu Gly Ser Cys Ser Ala Pro Asp Asn Asp Thr Ala Cys 
        35                  40                  45              


Val Ala Cys Arg His Tyr Tyr Tyr Ala Gly Val Cys Val Pro Ala Cys 
    50                  55                  60                  


Pro Pro Asn Thr Tyr Arg Phe Glu Gly Trp Arg Cys Val Asp Arg Asp 
65                  70                  75                  80  


Phe Cys Ala Asn Ile Leu Ser Ala Glu Ser Ser Asp Ser Glu Gly Phe 
                85                  90                  95      


Val Ile His Asp Gly Glu Cys Met Gln Glu Cys Pro Ser Gly Phe Ile 
            100                 105                 110         


Arg Asn Gly Ser Gln Ser Met Tyr Cys Ile Pro Cys Glu Gly Pro Cys 
        115                 120                 125             


Pro Lys Val Cys Glu Glu Glu Lys Lys Thr Lys Thr Ile Asp Ser Val 
    130                 135                 140                 


Thr Ser Ala Gln Met Leu Gln Gly Cys Thr Ile Phe Lys Gly Asn Leu 
145                 150                 155                 160 


Leu Ile Asn Ile Arg Arg Gly Asn Asn Ile Ala Ser Glu Leu Glu Asn 
                165                 170                 175     


Phe Met Gly Leu Ile Glu Val Val Thr Gly Tyr Val Lys Ile Arg His 
            180                 185                 190         


Ser His Ala Leu Val Ser Leu Ser Phe Leu Lys Asn Leu Arg Leu Ile 
        195                 200                 205             


Leu Gly Glu Glu Gln Leu Glu Gly Asn Tyr Ser Phe Tyr Val Leu Asp 
    210                 215                 220                 


Asn Gln Asn Leu Gln Gln Leu Trp Asp Trp Asp His Arg Asn Leu Thr 
225                 230                 235                 240 


Ile Lys Ala Gly Lys Met Tyr Phe Ala Phe Asn Pro Lys Leu Cys Val 
                245                 250                 255     


Ser Glu Ile Tyr Arg Met Glu Glu Val Thr Gly Thr Lys Gly Arg Gln 
            260                 265                 270         


Ser Lys Gly Asp Ile Asn Thr Arg Asn Asn Gly Glu Arg Ala Ser Cys 
        275                 280                 285             


Glu Ser Asp Val Leu His Phe Thr Ser Thr Thr Thr Ser Lys Asn Arg 
    290                 295                 300                 


Ile Ile Ile Thr Trp His Arg Tyr Arg Pro Pro Asp Tyr Arg Asp Leu 
305                 310                 315                 320 


Ile Ser Phe Thr Val Tyr Tyr Lys Glu Ala Pro Phe Lys Asn Val Thr 
                325                 330                 335     


Glu Tyr Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Asn Met Val 
            340                 345                 350         


Asp Val Asp Leu Pro Pro Asn Lys Asp Val Glu Pro Gly Ile Leu Leu 
        355                 360                 365             


His Gly Leu Lys Pro Trp Thr Gln Tyr Ala Val Tyr Val Lys Ala Val 
    370                 375                 380                 


Thr Leu Thr Met Val Glu Asn Asp His Ile Arg Gly Ala Lys Ser Glu 
385                 390                 395                 400 


Ile Leu Tyr Ile Arg Thr Asn Ala Ser Val Pro Ser Ile Pro Leu Asp 
                405                 410                 415     


Val Leu Ser Ala Ser Asn Ser Ser Ser Gln Leu Ile Val Lys Trp Asn 
            420                 425                 430         


Pro Pro Ser Leu Pro Asn Gly Asn Leu Ser Tyr Tyr Ile Val Arg Trp 
        435                 440                 445             


Gln Arg Gln Pro Gln Asp Gly Tyr Leu Tyr Arg His Asn Tyr Cys Ser 
    450                 455                 460                 


Lys Asp Lys Ile Pro Ile Arg Lys Tyr Ala Asp Gly Thr Ile Asp Ile 
465                 470                 475                 480 


Glu Glu Val Thr Glu Asn Pro Lys Thr Glu Val Cys Gly Gly Glu Lys 
                485                 490                 495     


Gly Pro Cys Cys Ala Cys Pro Lys Thr Glu Ala Glu Lys Gln Ala Glu 
            500                 505                 510         


Lys Glu Glu Ala Glu Tyr Arg Lys Val Phe Glu Asn Phe Leu His Asn 
        515                 520                 525             


Ser Ile Phe Val Pro Arg Pro Glu Arg Lys Arg Arg Asp Val Met Gln 
    530                 535                 540                 


Val Ala Asn Thr Thr Met Ser Ser Arg Ser Arg Asn Thr Thr Ala Ala 
545                 550                 555                 560 


Asp Thr Tyr Asn Ile Thr Asp Pro Glu Glu Leu Glu Thr Glu Tyr Pro 
                565                 570                 575     


Phe Phe Glu Ser Arg Val Asp Asn Lys Glu Arg Thr Val Ile Ser Asn 
            580                 585                 590         


Leu Arg Pro Phe Thr Leu Tyr Arg Ile Asp Ile His Ser Cys Asn His 
        595                 600                 605             


Glu Ala Glu Lys Leu Gly Cys Ser Ala Ser Asn Phe Val Phe Ala Arg 
    610                 615                 620                 


Thr Met Pro Ala Glu Gly Ala Asp Asp Ile Pro Gly Pro Val Thr Trp 
625                 630                 635                 640 


Glu Pro Arg Pro Glu Asn Ser Ile Phe Leu Lys Trp Pro Glu Pro Glu 
                645                 650                 655     


Asn Pro Asn Gly Leu Ile Leu Met Tyr Glu Ile Lys Tyr Gly Ser Gln 
            660                 665                 670         


Val Glu Asp Gln Arg Glu Cys Val Ser Arg Gln Glu Tyr Arg Lys Tyr 
        675                 680                 685             


Gly Gly Ala Lys Leu Asn Arg Leu Asn Pro Gly Asn Tyr Thr Ala Arg 
    690                 695                 700                 


Ile Gln Ala Thr Ser Leu Ser Gly Asn Gly Ser Trp Thr Asp Pro Val 
705                 710                 715                 720 


Phe Phe Tyr Val Gln Ala Lys Thr Gly Tyr Glu Asn Phe Ile His Leu 
                725                 730                 735     


Ile Ile Ala Leu Pro Val Ala Val Leu Leu Ile Val Gly Gly Leu Val 
            740                 745                 750         


Ile Met Leu Tyr Val Phe His Arg Lys Arg Asn Asn Ser Arg Leu Gly 
        755                 760                 765             


Asn Gly Val Leu Tyr Ala Ser Val Asn Pro Glu Tyr Phe Ser Ala Ala 
    770                 775                 780                 


Asp Val Tyr Val Pro Asp Glu Trp Glu Val Ala Arg Glu Lys Ile Thr 
785                 790                 795                 800 


Met Ser Arg Glu Leu Gly Gln Gly Ser Phe Gly Met Val Tyr Glu Gly 
                805                 810                 815     


Val Ala Lys Gly Val Val Lys Asp Glu Pro Glu Thr Arg Val Ala Ile 
            820                 825                 830         


Lys Thr Val Asn Glu Ala Ala Ser Met Arg Glu Arg Ile Glu Phe Leu 
        835                 840                 845             


Asn Glu Ala Ser Val Met Lys Glu Phe Asn Cys His His Val Val Arg 
    850                 855                 860                 


Leu Leu Gly Val Val Ser Gln Gly Gln Pro Thr Leu Val Ile Met Glu 
865                 870                 875                 880 


Leu Met Thr Arg Gly Asp Leu Lys Ser Tyr Leu Arg Ser Leu Arg Pro 
                885                 890                 895     


Glu Met Glu Asn Asn Pro Val Leu Ala Pro Pro Ser Leu Ser Lys Met 
            900                 905                 910         


Ile Gln Met Ala Gly Glu Ile Ala Asp Gly Met Ala Tyr Leu Asn Ala 
        915                 920                 925             


Asn Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Val Ala 
    930                 935                 940                 


Glu Asp Phe Thr Val Lys Ile Gly Asp Phe Gly Met Thr Arg Asp Ile 
945                 950                 955                 960 


Tyr Glu Thr Asp Tyr Tyr Arg Lys Gly Gly Lys Gly Leu Leu Pro Val 
                965                 970                 975     


Arg Trp Met Ser Pro Glu Ser Leu Lys Asp Gly Val Phe Thr Thr Tyr 
            980                 985                 990         


Ser Asp Val Trp Ser Phe Gly Val  Val Leu Trp Glu Ile  Ala Thr Leu 
        995                 1000                 1005             


Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn Glu Gln  Val Leu Arg 
    1010                 1015                 1020             


Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys Pro Asp  Asn Cys Pro 
    1025                 1030                 1035             


Asp Met  Leu Phe Glu Leu Met  Arg Met Cys Trp Gln  Tyr Asn Pro 
    1040                 1045                 1050             


Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile Ser Ser  Ile Lys Glu 
    1055                 1060                 1065             


Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser Phe Tyr  Tyr Ser Glu 
    1070                 1075                 1080             


Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu Asp Leu  Glu Pro Glu 
    1085                 1090                 1095             


Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser Ala Ser  Ser Ser Ser 
    1100                 1105                 1110             


Leu Pro  Leu Pro Asp Arg His  Ser Gly His Lys Ala  Glu Asn Gly 
    1115                 1120                 1125             


Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala Ser Phe  Asp Glu Arg 
    1130                 1135                 1140             


Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg Lys Asn  Glu Arg Ala 
    1145                 1150                 1155             


Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1160                 1165         


<210>  7
<211>  4104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo sapiens IGF1R H905C mutant

<400>  7
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcct gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatctgcg ggccaggcat cgacatccgc      120

aacgactatc agcagctgaa gcgcctggag aactgcacgg tgatcgaggg ctacctccac      180

atcctgctca tctccaaggc cgaggactac cgcagctacc gcttccccaa gctcacggtc      240

attaccgagt acttgctgct gttccgagtg gctggcctcg agagcctcgg agacctcttc      300

cccaacctca cggtcatccg cggctggaaa ctcttctaca actacgccct ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tacaacctga ggaacattac tcggggggcc      420

atcaggattg agaaaaatgc tgacctctgt tacctctcca ctgtggactg gtccctgatc      480

ctggatgcgg tgtccaataa ctacattgtg gggaataagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccatgga ggagaagccg atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaaccgc tgccagaaaa tgtgcccaag cacgtgtggg      660

aagcgggcgt gcaccgagaa caatgagtgc tgccaccccg agtgcctggg cagctgcagc      720

gcgcctgaca acgacacggc ctgtgtagct tgccgccact actactatgc cggtgtctgt      780

gtgcctgcct gcccgcccaa cacctacagg tttgagggct ggcgctgtgt ggaccgtgac      840

ttctgcgcca acatcctcag cgccgagagc agcgactccg aggggtttgt gatccacgac      900

ggcgagtgca tgcaggagtg cccctcgggc ttcatccgca acggcagcca gagcatgtac      960

tgcatccctt gtgaaggtcc ttgcccgaag gtctgtgagg aagaaaagaa aacaaagacc     1020

attgattctg ttacttctgc tcagatgctc caaggatgca ccatcttcaa gggcaatttg     1080

ctcattaaca tccgacgggg gaataacatt gcttcagagc tggagaactt catggggctc     1140

atcgaggtgg tgacgggcta cgtgaagatc cgccattctc atgccttggt ctccttgtcc     1200

ttcctaaaaa accttcgcct catcctagga gaggagcagc tagaagggaa ttactccttc     1260

tacgtcctcg acaaccagaa cttgcagcaa ctgtgggact gggaccaccg caacctgacc     1320

atcaaagcag ggaaaatgta ctttgctttc aatcccaaat tatgtgtttc cgaaatttac     1380

cgcatggagg aagtgacggg gactaaaggg cgccaaagca aaggggacat aaacaccagg     1440

aacaacgggg agagagcctc ctgtgaaagt gacgtcctgc atttcacctc caccaccacg     1500

tcgaagaatc gcatcatcat aacctggcac cggtaccggc cccctgacta cagggatctc     1560

atcagcttca ccgtttacta caaggaagca ccctttaaga atgtcacaga gtatgatggg     1620

caggatgcct gcggctccaa cagctggaac atggtggacg tggacctccc gcccaacaag     1680

gacgtggagc ccggcatctt actacatggg ctgaagccct ggactcagta cgccgtttac     1740

gtcaaggctg tgaccctcac catggtggag aacgaccata tccgtggggc caagagtgag     1800

atcttgtaca ttcgcaccaa tgcttcagtt ccttccattc ccttggacgt tctttcagca     1860

tcgaactcct cttctcagtt aatcgtgaag tggaaccctc cctctctgcc caacggcaac     1920

ctgagttact acattgtgcg ctggcagcgg cagcctcagg acggctacct ttaccggcac     1980

aattactgct ccaaagacaa aatccccatc aggaagtatg ccgacggcac catcgacatt     2040

gaggaggtca cagagaaccc caagactgag gtgtgtggtg gggagaaagg gccttgctgc     2100

gcctgcccca aaactgaagc cgagaagcag gccgagaagg aggaggctga ataccgcaaa     2160

gtctttgaga atttcctgca caactccatc ttcgtgccca gacctgaaag gaagcggaga     2220

gatgtcatgc aagtggccaa caccaccatg tccagccgaa gcaggaacac cacggccgca     2280

gacacctaca acatcaccga cccggaagag ctggagacag agtacccttt ctttgagagc     2340

agagtggata acaaggagag aactgtcatt tctaaccttc ggcctttcac attgtaccgc     2400

atcgatatcc acagctgcaa ccacgaggct gagaagctgg gctgcagcgc ctccaacttc     2460

gtctttgcaa ggactatgcc cgcagaagga gcagatgaca ttcctgggcc agtgacctgg     2520

gagccaaggc ctgaaaactc catcttttta aagtggccgg aacctgagaa tcccaatgga     2580

ttgattctaa tgtatgaaat aaaatacgga tcacaagttg aggatcagcg agaatgtgtg     2640

tccagacagg aatacaggaa gtatggaggg gccaagctaa accggctaaa cccggggaac     2700

tacacagccc ggattcaggc cacatctctc tctgggaatg ggtcgtggac agatcctgtg     2760

ttcttctatg tccaggccaa aacaggatat gaaaacttca tctgtctgat catcgctctg     2820

cccgtcgctg tcctgttgat cgtgggaggg ttggtgatta tgctgtacgt cttccataga     2880

aagagaaata acagcaggct ggggaatgga gtgctgtatg cctctgtgaa cccggagtac     2940

ttcagcgctg ctgatgtgta cgttcctgat gagtgggagg tggctcggga gaagatcacc     3000

atgagccggg aacttgggca ggggtcgttt gggatggtct atgaaggagt tgccaagggt     3060

gtggtgaaag atgaacctga aaccagagtg gccattaaaa cagtgaacga ggccgcaagc     3120

atgcgtgaga ggattgagtt tctcaacgaa gcttctgtga tgaaggagtt caattgtcac     3180

catgtggtgc gattgctggg tgtggtgtcc caaggccagc caacactggt catcatggaa     3240

ctgatgacac ggggcgatct caaaagttat ctccggtctc tgaggccaga aatggagaat     3300

aatccagtcc tagcacctcc aagcctgagc aagatgattc agatggccgg agagattgca     3360

gacggcatgg catacctcaa cgccaataag ttcgtccaca gagaccttgc tgcccggaat     3420

tgcatggtag ccgaagattt cacagtcaaa atcggagatt ttggtatgac gcgagatatc     3480

tatgagacag actattaccg gaaaggaggg aaagggctgc tgcccgtgcg ctggatgtct     3540

cctgagtccc tcaaggatgg agtcttcacc acttactcgg acgtctggtc cttcggggtc     3600

gtcctctggg agatcgccac actggccgag cagccctacc agggcttgtc caacgagcaa     3660

gtccttcgct tcgtcatgga gggcggcctt ctggacaagc cagacaactg tcctgacatg     3720

ctgtttgaac tgatgcgcat gtgctggcag tataacccca agatgaggcc ttccttcctg     3780

gagatcatca gcagcatcaa agaggagatg gagcctggct tccgggaggt ctccttctac     3840

tacagcgagg agaacaagct gcccgagccg gaggagctgg acctggagcc agagaacatg     3900

gagagcgtcc ccctggaccc ctcggcctcc tcgtcctccc tgccactgcc cgacagacac     3960

tcaggacaca aggccgagaa cggccccggc cctggggtgc tggtcctccg cgccagcttc     4020

gacgagagac agccttacgc ccacatgaac gggggccgca agaacgagcg ggccttgccg     4080

ctgccccagt cttcgacctg ctga                                            4104


<210>  8
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Homo sapiens IGF1R H905C mutant

<400>  8

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Leu Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Tyr Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Val Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Met Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Thr Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys Ser 
225                 230                 235                 240 


Ala Pro Asp Asn Asp Thr Ala Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Ala Gly Val Cys Val Pro Ala Cys Pro Pro Asn Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Leu Ser Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Glu Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Gly Ser Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Glu Glu Glu Lys 
                325                 330                 335     


Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln Gly 
            340                 345                 350         


Cys Thr Ile Phe Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly Asn 
        355                 360                 365             


Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val Val 
    370                 375                 380                 


Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu Ser 
385                 390                 395                 400 


Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu Gly 
                405                 410                 415     


Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu Trp 
            420                 425                 430         


Asp Trp Asp His Arg Asn Leu Thr Ile Lys Ala Gly Lys Met Tyr Phe 
        435                 440                 445             


Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu Glu 
    450                 455                 460                 


Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr Arg 
465                 470                 475                 480 


Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu His Phe Thr 
                485                 490                 495     


Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg Tyr 
            500                 505                 510         


Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr Lys 
        515                 520                 525             


Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala Cys 
    530                 535                 540                 


Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn Lys 
545                 550                 555                 560 


Asp Val Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr Gln 
                565                 570                 575     


Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn Asp 
            580                 585                 590         


His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn Ala 
        595                 600                 605             


Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser Ser 
    610                 615                 620                 


Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Ser Leu Pro Asn Gly Asn 
625                 630                 635                 640 


Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly Tyr 
                645                 650                 655     


Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg Lys 
            660                 665                 670         


Tyr Ala Asp Gly Thr Ile Asp Ile Glu Glu Val Thr Glu Asn Pro Lys 
        675                 680                 685             


Thr Glu Val Cys Gly Gly Glu Lys Gly Pro Cys Cys Ala Cys Pro Lys 
    690                 695                 700                 


Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg Lys 
705                 710                 715                 720 


Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro Glu 
                725                 730                 735     


Arg Lys Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser Ser 
            740                 745                 750         


Arg Ser Arg Asn Thr Thr Ala Ala Asp Thr Tyr Asn Ile Thr Asp Pro 
        755                 760                 765             


Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp Asn 
    770                 775                 780                 


Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr Arg 
785                 790                 795                 800 


Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys Ser 
                805                 810                 815     


Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala Asp 
            820                 825                 830         


Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser Ile 
        835                 840                 845             


Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu Met 
    850                 855                 860                 


Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys Val 
865                 870                 875                 880 


Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg Leu 
                885                 890                 895     


Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser Gly 
            900                 905                 910         


Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Gln Ala Lys Thr 
        915                 920                 925             


Gly Tyr Glu Asn Phe Ile His Leu Ile Ile Ala Leu Pro Val Ala Val 
    930                 935                 940                 


Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His Arg 
945                 950                 955                 960 


Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser Val 
                965                 970                 975     


Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu Trp 
            980                 985                 990         


Glu Val Ala Arg Glu Lys Ile Thr  Met Ser Arg Glu Leu  Gly Gln Gly 
        995                 1000                 1005             


Ser Phe  Gly Met Val Tyr Glu  Gly Val Ala Lys Gly  Val Val Lys 
    1010                 1015                 1020             


Asp Glu  Pro Glu Thr Arg Val  Ala Ile Lys Thr Val  Asn Glu Ala 
    1025                 1030                 1035             


Ala Ser  Met Arg Glu Arg Ile  Glu Phe Leu Asn Glu  Ala Ser Val 
    1040                 1045                 1050             


Met Lys  Glu Phe Asn Cys His  His Val Val Arg Leu  Leu Gly Val 
    1055                 1060                 1065             


Val Ser  Gln Gly Gln Pro Thr  Leu Val Ile Met Glu  Leu Met Thr 
    1070                 1075                 1080             


Arg Gly  Asp Leu Lys Ser Tyr  Leu Arg Ser Leu Arg  Pro Glu Met 
    1085                 1090                 1095             


Glu Asn  Asn Pro Val Leu Ala  Pro Pro Ser Leu Ser  Lys Met Ile 
    1100                 1105                 1110             


Gln Met  Ala Gly Glu Ile Ala  Asp Gly Met Ala Tyr  Leu Asn Ala 
    1115                 1120                 1125             


Asn Lys  Phe Val His Arg Asp  Leu Ala Ala Arg Asn  Cys Met Val 
    1130                 1135                 1140             


Ala Glu  Asp Phe Thr Val Lys  Ile Gly Asp Phe Gly  Met Thr Arg 
    1145                 1150                 1155             


Asp Ile  Tyr Glu Thr Asp Tyr  Tyr Arg Lys Gly Gly  Lys Gly Leu 
    1160                 1165                 1170             


Leu Pro  Val Arg Trp Met Ser  Pro Glu Ser Leu Lys  Asp Gly Val 
    1175                 1180                 1185             


Phe Thr  Thr Tyr Ser Asp Val  Trp Ser Phe Gly Val  Val Leu Trp 
    1190                 1195                 1200             


Glu Ile  Ala Thr Leu Ala Glu  Gln Pro Tyr Gln Gly  Leu Ser Asn 
    1205                 1210                 1215             


Glu Gln  Val Leu Arg Phe Val  Met Glu Gly Gly Leu  Leu Asp Lys 
    1220                 1225                 1230             


Pro Asp  Asn Cys Pro Asp Met  Leu Phe Glu Leu Met  Arg Met Cys 
    1235                 1240                 1245             


Trp Gln  Tyr Asn Pro Lys Met  Arg Pro Ser Phe Leu  Glu Ile Ile 
    1250                 1255                 1260             


Ser Ser  Ile Lys Glu Glu Met  Glu Pro Gly Phe Arg  Glu Val Ser 
    1265                 1270                 1275             


Phe Tyr  Tyr Ser Glu Glu Asn  Lys Leu Pro Glu Pro  Glu Glu Leu 
    1280                 1285                 1290             


Asp Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1295                 1300                 1305             


Ala Ser  Ser Ser Ser Leu Pro  Leu Pro Asp Arg His  Ser Gly His 
    1310                 1315                 1320             


Lys Ala  Glu Asn Gly Pro Gly  Pro Gly Val Leu Val  Leu Arg Ala 
    1325                 1330                 1335             


Ser Phe  Asp Glu Arg Gln Pro  Tyr Ala His Met Asn  Gly Gly Arg 
    1340                 1345                 1350             


Lys Asn  Glu Arg Ala Leu Pro  Leu Pro Gln Ser Ser  Thr Cys 
    1355                 1360                 1365         


<210>  9
<211>  3513
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rattus norvegicus IGFR1 Del1 mutant

<400>  9
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcgt gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga tgccacccgg agtgcctagg cagctgccac      120

acaccggacg acaacacaac ctgcgtggcc tgccgacact actactacaa aggcgtgtgc      180

gtgcctgcct gcccgcctgg cacctacagg ttcgagggct ggcgctgtgt ggaccgggat      240

ttctgcgcca acatccccaa cgccgagagc agtgactcag atggcttcgt catccacgat      300

ggcgagtgca tgcaggagtg tccatcaggc ttcatccgca acagcaccca gagcatgtac      360

tgtatcccct gtgaaggccc ctgccccaag gtctgcggcg atgaagaaaa gaaaacgaaa      420

accatcgatt ctgtgacgtc tgcccagatg ctccaagggt gcaccatttt gaagggcaat      480

ctgcttatta acatccggcg aggcaataac attgcctcgg aattggagaa cttcatgggg      540

ctcatcgagg tggtgactgg ctacgtgaag atccgccatt cccatgcctt ggtctccttg      600

tccttcctga agaaccttcg tctcatctta ggagaggagc agctagaagg gaactactcc      660

ttctatgtcc tggacaacca gaacttgcag cagctgtggg actggaacca ccggaacctg      720

accgtcaggt cagggaaaat gtacttcgct ttcaatccca agctgtgtgt ctctgaaatt      780

taccggatgg aggaggtgac aggaacaaag ggacggcaga gcaaaggaga cataaacacc      840

aggaacaacg gagagcgagc ttcctgtgaa agtgatgttc tccgtttcac ctccaccacc      900

acctggaaga accgcatcat cataacgtgg caccggtacc ggccgccgga ctaccgggat      960

ctcatcagtt tcacagtcta ctacaaggag gcacccttta aaaacgtcac ggaatacgac     1020

gggcaggatg cctgtggctc caacagctgg aacatggtgg acgtggacct gcctccgaac     1080

aaggaggggg agcctggcat tttgctgcat gggctgaagc cctggaccca gtatgcagtc     1140

tatgtcaagg ctgtgaccct caccatggtg gaaaacgacc acatccgtgg ggccaaaagt     1200

gaaatcttgt acattcgcac caacgcttca gttccttcca ttcctctaga tgtcctctcg     1260

gcatcaaact cctcctctca gctgatcgtg aagtggaacc ccccaactct gcccaatggt     1320

aacttgagtt actacattgt gaggtggcag cggcagccgc aggatggcta tctgttccgg     1380

cacaactact gctccaaaga caaaataccc atcagaaagt acgccgatgg taccatcgat     1440

gtggaggagg tgacagaaaa tcccaagaca gaagtgtgcg gtggtgataa agggccgtgc     1500

tgtgcctgtc ctaaaaccga agctgagaag caggctgaga aggaggaggc tgagtaccgt     1560

aaagtctttg agaatttcct tcacaactcc atctttgtgc ccagacctga gaggaggcgg     1620

agagatgtcc tgcaggtggc taacaccacc atgtccagcc gaagcaggaa caccacggta     1680

gctgacacct acaatatcac agacccggaa gagttcgaga cagaataccc tttctttgag     1740

agcagagtgg ataacaagga gaggactgtc atttccaacc tccggccttt cactctgtac     1800

cgtatcgata tccacagctg caaccacgag gctgagaagc tgggctgcag cgcctccaac     1860

tttgtctttg caagaaccat gccagcagaa ggagcagatg acattcctgg cccagtgacc     1920

tgggagccaa gacctgaaaa ctccatcttt ttaaagtggc cagaacccga gaaccccaac     1980

ggattgattc taatgtatga aataaaatac ggatcgcaag tcgaggatca gcgggaatgt     2040

gtgtccagac aggagtacag gaagtatgga ggggccaaac ttaaccgtct aaacccaggg     2100

aactatacgg cccggattca ggctacctcc ctctctggga atgggtcgtg gacagatcct     2160

gtgttcttct atgtcccagc caaaacaacg tatgagaatt tcatgcatct gatcattgct     2220

ctgccggttg ccatcctgct gattgtgggg ggcctggtaa tcatgctgta tgtcttccat     2280

agaaagagga ataacagcag attgggcaac ggggtgctgt acgcctctgt gaaccccgag     2340

tatttcagcg cagctgatgt gtacgtgcct gatgaatggg aggtagctcg ggagaagatc     2400

accatgaacc gggagctcgg acaagggtcc ttcgggatgg tctatgaagg agtggccaag     2460

ggcgtggtca aggacgagcc tgaaaccaga gtggccatca agacagtgaa tgaggctgca     2520

agtatgcgtg agagaattga gtttctcaac gaggcctcag tgatgaagga gttcaactgt     2580

caccatgtgg tccggttgct gggtgtagta tcccaaggcc agcccaccct ggtcatcatg     2640

gaactaatga cacgtggcga tctcaaaagt tatctccggt ctctaaggcc agaggtggag     2700

aataatctag tcctgattcc tccgagctta agcaagatga tccagatggc tggagagatt     2760

gcagatggca tggcctacct caatgccaac aagttcgtcc acagagacct ggctgctcgg     2820

aactgcatgg tagctgaaga tttcacagtc aaaattggag attttggtat gacacgagac     2880

atctacgaga cggactacta ccggaaaggc gggaagggct tgctgcctgt gcgctggatg     2940

tctcccgagt ccctcaagga tggcgtcttc accactcatt ccgatgtctg gtcctttggg     3000

gtcgtcctct gggagatcgc cactctggct gagcagccgt accagggcct gtccaacgag     3060

caagttcttc gtttcgtcat ggagggcggc cttctggaca agccggataa ctgccccgat     3120

atgctgtttg aacttatgcg catgtgctgg cagtacaacc ccaagatgcg gccctccttc     3180

ctggagatca tcggaagcat caaggatgag atggagccca gtttccagga ggtctccttc     3240

tactacagcg aggagaacaa gcctccagag ccggaggagc tggagatgga gctggagctg     3300

gagcccgaga acatggagag cgtcccgctg gacccttcgg cctcctcagc ctccctgcct     3360

ctgcctgaaa gacactcagg acacaaggct gagaacggcc ctggcgtgct ggttctccgt     3420

gccagttttg atgagagaca gccttacgct cacatgaatg ggggacgcgc caacgagagg     3480

gccttgcctc tgccccagtc ctcaacctgc tga                                  3513


<210>  10
<211>  1170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rattus norvegicus IGFR1 Del1 mutant

<400>  10

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Val Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Cys His 
            20                  25                  30          


Pro Glu Cys Leu Gly Ser Cys His Thr Pro Asp Asp Asn Thr Thr Cys 
        35                  40                  45              


Val Ala Cys Arg His Tyr Tyr Tyr Lys Gly Val Cys Val Pro Ala Cys 
    50                  55                  60                  


Pro Pro Gly Thr Tyr Arg Phe Glu Gly Trp Arg Cys Val Asp Arg Asp 
65                  70                  75                  80  


Phe Cys Ala Asn Ile Pro Asn Ala Glu Ser Ser Asp Ser Asp Gly Phe 
                85                  90                  95      


Val Ile His Asp Gly Glu Cys Met Gln Glu Cys Pro Ser Gly Phe Ile 
            100                 105                 110         


Arg Asn Ser Thr Gln Ser Met Tyr Cys Ile Pro Cys Glu Gly Pro Cys 
        115                 120                 125             


Pro Lys Val Cys Gly Asp Glu Glu Lys Lys Thr Lys Thr Ile Asp Ser 
    130                 135                 140                 


Val Thr Ser Ala Gln Met Leu Gln Gly Cys Thr Ile Leu Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Ile Asn Ile Arg Arg Gly Asn Asn Ile Ala Ser Glu Leu Glu 
                165                 170                 175     


Asn Phe Met Gly Leu Ile Glu Val Val Thr Gly Tyr Val Lys Ile Arg 
            180                 185                 190         


His Ser His Ala Leu Val Ser Leu Ser Phe Leu Lys Asn Leu Arg Leu 
        195                 200                 205             


Ile Leu Gly Glu Glu Gln Leu Glu Gly Asn Tyr Ser Phe Tyr Val Leu 
    210                 215                 220                 


Asp Asn Gln Asn Leu Gln Gln Leu Trp Asp Trp Asn His Arg Asn Leu 
225                 230                 235                 240 


Thr Val Arg Ser Gly Lys Met Tyr Phe Ala Phe Asn Pro Lys Leu Cys 
                245                 250                 255     


Val Ser Glu Ile Tyr Arg Met Glu Glu Val Thr Gly Thr Lys Gly Arg 
            260                 265                 270         


Gln Ser Lys Gly Asp Ile Asn Thr Arg Asn Asn Gly Glu Arg Ala Ser 
        275                 280                 285             


Cys Glu Ser Asp Val Leu Arg Phe Thr Ser Thr Thr Thr Trp Lys Asn 
    290                 295                 300                 


Arg Ile Ile Ile Thr Trp His Arg Tyr Arg Pro Pro Asp Tyr Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Phe Thr Val Tyr Tyr Lys Glu Ala Pro Phe Lys Asn Val 
                325                 330                 335     


Thr Glu Tyr Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Asn Met 
            340                 345                 350         


Val Asp Val Asp Leu Pro Pro Asn Lys Glu Gly Glu Pro Gly Ile Leu 
        355                 360                 365             


Leu His Gly Leu Lys Pro Trp Thr Gln Tyr Ala Val Tyr Val Lys Ala 
    370                 375                 380                 


Val Thr Leu Thr Met Val Glu Asn Asp His Ile Arg Gly Ala Lys Ser 
385                 390                 395                 400 


Glu Ile Leu Tyr Ile Arg Thr Asn Ala Ser Val Pro Ser Ile Pro Leu 
                405                 410                 415     


Asp Val Leu Ser Ala Ser Asn Ser Ser Ser Gln Leu Ile Val Lys Trp 
            420                 425                 430         


Asn Pro Pro Thr Leu Pro Asn Gly Asn Leu Ser Tyr Tyr Ile Val Arg 
        435                 440                 445             


Trp Gln Arg Gln Pro Gln Asp Gly Tyr Leu Phe Arg His Asn Tyr Cys 
    450                 455                 460                 


Ser Lys Asp Lys Ile Pro Ile Arg Lys Tyr Ala Asp Gly Thr Ile Asp 
465                 470                 475                 480 


Val Glu Glu Val Thr Glu Asn Pro Lys Thr Glu Val Cys Gly Gly Asp 
                485                 490                 495     


Lys Gly Pro Cys Cys Ala Cys Pro Lys Thr Glu Ala Glu Lys Gln Ala 
            500                 505                 510         


Glu Lys Glu Glu Ala Glu Tyr Arg Lys Val Phe Glu Asn Phe Leu His 
        515                 520                 525             


Asn Ser Ile Phe Val Pro Arg Pro Glu Arg Arg Arg Arg Asp Val Leu 
    530                 535                 540                 


Gln Val Ala Asn Thr Thr Met Ser Ser Arg Ser Arg Asn Thr Thr Val 
545                 550                 555                 560 


Ala Asp Thr Tyr Asn Ile Thr Asp Pro Glu Glu Phe Glu Thr Glu Tyr 
                565                 570                 575     


Pro Phe Phe Glu Ser Arg Val Asp Asn Lys Glu Arg Thr Val Ile Ser 
            580                 585                 590         


Asn Leu Arg Pro Phe Thr Leu Tyr Arg Ile Asp Ile His Ser Cys Asn 
        595                 600                 605             


His Glu Ala Glu Lys Leu Gly Cys Ser Ala Ser Asn Phe Val Phe Ala 
    610                 615                 620                 


Arg Thr Met Pro Ala Glu Gly Ala Asp Asp Ile Pro Gly Pro Val Thr 
625                 630                 635                 640 


Trp Glu Pro Arg Pro Glu Asn Ser Ile Phe Leu Lys Trp Pro Glu Pro 
                645                 650                 655     


Glu Asn Pro Asn Gly Leu Ile Leu Met Tyr Glu Ile Lys Tyr Gly Ser 
            660                 665                 670         


Gln Val Glu Asp Gln Arg Glu Cys Val Ser Arg Gln Glu Tyr Arg Lys 
        675                 680                 685             


Tyr Gly Gly Ala Lys Leu Asn Arg Leu Asn Pro Gly Asn Tyr Thr Ala 
    690                 695                 700                 


Arg Ile Gln Ala Thr Ser Leu Ser Gly Asn Gly Ser Trp Thr Asp Pro 
705                 710                 715                 720 


Val Phe Phe Tyr Val Pro Ala Lys Thr Thr Tyr Glu Asn Phe Met His 
                725                 730                 735     


Leu Ile Ile Ala Leu Pro Val Ala Ile Leu Leu Ile Val Gly Gly Leu 
            740                 745                 750         


Val Ile Met Leu Tyr Val Phe His Arg Lys Arg Asn Asn Ser Arg Leu 
        755                 760                 765             


Gly Asn Gly Val Leu Tyr Ala Ser Val Asn Pro Glu Tyr Phe Ser Ala 
    770                 775                 780                 


Ala Asp Val Tyr Val Pro Asp Glu Trp Glu Val Ala Arg Glu Lys Ile 
785                 790                 795                 800 


Thr Met Asn Arg Glu Leu Gly Gln Gly Ser Phe Gly Met Val Tyr Glu 
                805                 810                 815     


Gly Val Ala Lys Gly Val Val Lys Asp Glu Pro Glu Thr Arg Val Ala 
            820                 825                 830         


Ile Lys Thr Val Asn Glu Ala Ala Ser Met Arg Glu Arg Ile Glu Phe 
        835                 840                 845             


Leu Asn Glu Ala Ser Val Met Lys Glu Phe Asn Cys His His Val Val 
    850                 855                 860                 


Arg Leu Leu Gly Val Val Ser Gln Gly Gln Pro Thr Leu Val Ile Met 
865                 870                 875                 880 


Glu Leu Met Thr Arg Gly Asp Leu Lys Ser Tyr Leu Arg Ser Leu Arg 
                885                 890                 895     


Pro Glu Val Glu Asn Asn Leu Val Leu Ile Pro Pro Ser Leu Ser Lys 
            900                 905                 910         


Met Ile Gln Met Ala Gly Glu Ile Ala Asp Gly Met Ala Tyr Leu Asn 
        915                 920                 925             


Ala Asn Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met Val 
    930                 935                 940                 


Ala Glu Asp Phe Thr Val Lys Ile Gly Asp Phe Gly Met Thr Arg Asp 
945                 950                 955                 960 


Ile Tyr Glu Thr Asp Tyr Tyr Arg Lys Gly Gly Lys Gly Leu Leu Pro 
                965                 970                 975     


Val Arg Trp Met Ser Pro Glu Ser Leu Lys Asp Gly Val Phe Thr Thr 
            980                 985                 990         


His Ser Asp Val Trp Ser Phe Gly  Val Val Leu Trp Glu  Ile Ala Thr 
        995                 1000                 1005             


Leu Ala  Glu Gln Pro Tyr Gln  Gly Leu Ser Asn Glu  Gln Val Leu 
    1010                 1015                 1020             


Arg Phe  Val Met Glu Gly Gly  Leu Leu Asp Lys Pro  Asp Asn Cys 
    1025                 1030                 1035             


Pro Asp  Met Leu Phe Glu Leu  Met Arg Met Cys Trp  Gln Tyr Asn 
    1040                 1045                 1050             


Pro Lys  Met Arg Pro Ser Phe  Leu Glu Ile Ile Gly  Ser Ile Lys 
    1055                 1060                 1065             


Asp Glu  Met Glu Pro Ser Phe  Gln Glu Val Ser Phe  Tyr Tyr Ser 
    1070                 1075                 1080             


Glu Glu  Asn Lys Pro Pro Glu  Pro Glu Glu Leu Glu  Met Glu Leu 
    1085                 1090                 1095             


Glu Leu  Glu Pro Glu Asn Met  Glu Ser Val Pro Leu  Asp Pro Ser 
    1100                 1105                 1110             


Ala Ser  Ser Ala Ser Leu Pro  Leu Pro Glu Arg His  Ser Gly His 
    1115                 1120                 1125             


Lys Ala  Glu Asn Gly Pro Gly  Val Leu Val Leu Arg  Ala Ser Phe 
    1130                 1135                 1140             


Asp Glu  Arg Gln Pro Tyr Ala  His Met Asn Gly Gly  Arg Ala Asn 
    1145                 1150                 1155             


Glu Arg  Ala Leu Pro Leu Pro  Gln Ser Ser Thr Cys  
    1160                 1165                 1170 


<210>  11
<211>  4113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Rattus norvegicus IGFR1 H906C mutant

<400>  11
atgaagtctg gctccggagg agggtccccg acctcgctgt gggggctcgt gtttctctcc       60

gccgcgctct cgctctggcc gacgagtgga gaaatttgtg ggcccggcat tgacatccgc      120

aacgactatc agcagctgaa gcgcctggaa aactgcacgg tgatcgaggg cttcctccac      180

atcctgctca tctccaaggc cgaggactac cgaagctacc gcttccccaa gctcacggtc      240

atcaccgagt acttgctgct gtttcgagtg gccggcctcg agagcctggg agacctcttc      300

ccgaacctca cagtcatccg tggctggaaa ctcttctaca attacgcact ggtcatcttc      360

gagatgacca atctcaagga tattgggctt tataatctga ggaacattac tcggggggcc      420

atcaggattg agaaaaacgc tgacctctgt tacctctcca ccatagactg gtctctcatc      480

ttggatgcgg tgtccaataa ctacattgtg gggaacaagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccttgga ggagaagccc atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaatcgc tgccagaaaa tgtgcccaag tgtgtgtggg      660

aagcgagcct gcaccgagaa caatgagtgc tgccacccgg agtgcctagg cagctgccac      720

acaccggacg acaacacaac ctgcgtggcc tgccgacact actactacaa aggcgtgtgc      780

gtgcctgcct gcccgcctgg cacctacagg ttcgagggct ggcgctgtgt ggaccgggat      840

ttctgcgcca acatccccaa cgccgagagc agtgactcag atggcttcgt catccacgat      900

ggcgagtgca tgcaggagtg tccatcaggc ttcatccgca acagcaccca gagcatgtac      960

tgtatcccct gtgaaggccc ctgccccaag gtctgcggcg atgaagaaaa gaaaacgaaa     1020

accatcgatt ctgtgacgtc tgcccagatg ctccaagggt gcaccatttt gaagggcaat     1080

ctgcttatta acatccggcg aggcaataac attgcctcgg aattggagaa cttcatgggg     1140

ctcatcgagg tggtgactgg ctacgtgaag atccgccatt cccatgcctt ggtctccttg     1200

tccttcctga agaaccttcg tctcatctta ggagaggagc agctagaagg gaactactcc     1260

ttctatgtcc tggacaacca gaacttgcag cagctgtggg actggaacca ccggaacctg     1320

accgtcaggt cagggaaaat gtacttcgct ttcaatccca agctgtgtgt ctctgaaatt     1380

taccggatgg aggaggtgac aggaacaaag ggacggcaga gcaaaggaga cataaacacc     1440

aggaacaacg gagagcgagc ttcctgtgaa agtgatgttc tccgtttcac ctccaccacc     1500

acctggaaga accgcatcat cataacgtgg caccggtacc ggccgccgga ctaccgggat     1560

ctcatcagtt tcacagtcta ctacaaggag gcacccttta aaaacgtcac ggaatacgac     1620

gggcaggatg cctgtggctc caacagctgg aacatggtgg acgtggacct gcctccgaac     1680

aaggaggggg agcctggcat tttgctgcat gggctgaagc cctggaccca gtatgcagtc     1740

tatgtcaagg ctgtgaccct caccatggtg gaaaacgacc acatccgtgg ggccaaaagt     1800

gaaatcttgt acattcgcac caacgcttca gttccttcca ttcctctaga tgtcctctcg     1860

gcatcaaact cctcctctca gctgatcgtg aagtggaacc ccccaactct gcccaatggt     1920

aacttgagtt actacattgt gaggtggcag cggcagccgc aggatggcta tctgttccgg     1980

cacaactact gctccaaaga caaaataccc atcagaaagt acgccgatgg taccatcgat     2040

gtggaggagg tgacagaaaa tcccaagaca gaagtgtgcg gtggtgataa agggccgtgc     2100

tgtgcctgtc ctaaaaccga agctgagaag caggctgaga aggaggaggc tgagtaccgt     2160

aaagtctttg agaatttcct tcacaactcc atctttgtgc ccagacctga gaggaggcgg     2220

agagatgtcc tgcaggtggc taacaccacc atgtccagcc gaagcaggaa caccacggta     2280

gctgacacct acaatatcac agacccggaa gagttcgaga cagaataccc tttctttgag     2340

agcagagtgg ataacaagga gaggactgtc atttccaacc tccggccttt cactctgtac     2400

cgtatcgata tccacagctg caaccacgag gctgagaagc tgggctgcag cgcctccaac     2460

tttgtctttg caagaaccat gccagcagaa ggagcagatg acattcctgg cccagtgacc     2520

tgggagccaa gacctgaaaa ctccatcttt ttaaagtggc cagaacccga gaaccccaac     2580

ggattgattc taatgtatga aataaaatac ggatcgcaag tcgaggatca gcgggaatgt     2640

gtgtccagac aggagtacag gaagtatgga ggggccaaac ttaaccgtct aaacccaggg     2700

aactatacgg cccggattca ggctacctcc ctctctggga atgggtcgtg gacagatcct     2760

gtgttcttct atgtcccagc caaaacaacg tatgagaatt tcatgtgtct gatcattgct     2820

ctgccggttg ccatcctgct gattgtgggg ggcctggtaa tcatgctgta tgtcttccat     2880

agaaagagga ataacagcag attgggcaac ggggtgctgt acgcctctgt gaaccccgag     2940

tatttcagcg cagctgatgt gtacgtgcct gatgaatggg aggtagctcg ggagaagatc     3000

accatgaacc gggagctcgg acaagggtcc ttcgggatgg tctatgaagg agtggccaag     3060

ggcgtggtca aggacgagcc tgaaaccaga gtggccatca agacagtgaa tgaggctgca     3120

agtatgcgtg agagaattga gtttctcaac gaggcctcag tgatgaagga gttcaactgt     3180

caccatgtgg tccggttgct gggtgtagta tcccaaggcc agcccaccct ggtcatcatg     3240

gaactaatga cacgtggcga tctcaaaagt tatctccggt ctctaaggcc agaggtggag     3300

aataatctag tcctgattcc tccgagctta agcaagatga tccagatggc tggagagatt     3360

gcagatggca tggcctacct caatgccaac aagttcgtcc acagagacct ggctgctcgg     3420

aactgcatgg tagctgaaga tttcacagtc aaaattggag attttggtat gacacgagac     3480

atctacgaga cggactacta ccggaaaggc gggaagggct tgctgcctgt gcgctggatg     3540

tctcccgagt ccctcaagga tggcgtcttc accactcatt ccgatgtctg gtcctttggg     3600

gtcgtcctct gggagatcgc cactctggct gagcagccgt accagggcct gtccaacgag     3660

caagttcttc gtttcgtcat ggagggcggc cttctggaca agccggataa ctgccccgat     3720

atgctgtttg aacttatgcg catgtgctgg cagtacaacc ccaagatgcg gccctccttc     3780

ctggagatca tcggaagcat caaggatgag atggagccca gtttccagga ggtctccttc     3840

tactacagcg aggagaacaa gcctccagag ccggaggagc tggagatgga gctggagctg     3900

gagcccgaga acatggagag cgtcccgctg gacccttcgg cctcctcagc ctccctgcct     3960

ctgcctgaaa gacactcagg acacaaggct gagaacggcc ctggcgtgct ggttctccgt     4020

gccagttttg atgagagaca gccttacgct cacatgaatg ggggacgcgc caacgagagg     4080

gccttgcctc tgccccagtc ctcaacctgc tga                                  4113


<210>  12
<211>  1370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rattus norvegicus IGFR1 H906C mutant

<400>  12

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Val Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Phe Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Ile Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Leu Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Arg Cys Gln Lys Met Cys Pro Ser Val Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys His 
225                 230                 235                 240 


Thr Pro Asp Asp Asn Thr Thr Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Lys Gly Val Cys Val Pro Ala Cys Pro Pro Gly Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Pro Asn Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Asp Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Ser Thr Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Gly Asp Glu Glu 
                325                 330                 335     


Lys Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln 
            340                 345                 350         


Gly Cys Thr Ile Leu Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly 
        355                 360                 365             


Asn Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val 
    370                 375                 380                 


Val Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu 
385                 390                 395                 400 


Ser Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu 
                405                 410                 415     


Gly Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu 
            420                 425                 430         


Trp Asp Trp Asn His Arg Asn Leu Thr Val Arg Ser Gly Lys Met Tyr 
        435                 440                 445             


Phe Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu 
    450                 455                 460                 


Glu Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr 
465                 470                 475                 480 


Arg Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu Arg Phe 
                485                 490                 495     


Thr Ser Thr Thr Thr Trp Lys Asn Arg Ile Ile Ile Thr Trp His Arg 
            500                 505                 510         


Tyr Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr 
        515                 520                 525             


Lys Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala 
    530                 535                 540                 


Cys Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn 
545                 550                 555                 560 


Lys Glu Gly Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr 
                565                 570                 575     


Gln Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn 
            580                 585                 590         


Asp His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn 
        595                 600                 605             


Ala Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser 
    610                 615                 620                 


Ser Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Thr Leu Pro Asn Gly 
625                 630                 635                 640 


Asn Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly 
                645                 650                 655     


Tyr Leu Phe Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg 
            660                 665                 670         


Lys Tyr Ala Asp Gly Thr Ile Asp Val Glu Glu Val Thr Glu Asn Pro 
        675                 680                 685             


Lys Thr Glu Val Cys Gly Gly Asp Lys Gly Pro Cys Cys Ala Cys Pro 
    690                 695                 700                 


Lys Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg 
705                 710                 715                 720 


Lys Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro 
                725                 730                 735     


Glu Arg Arg Arg Arg Asp Val Leu Gln Val Ala Asn Thr Thr Met Ser 
            740                 745                 750         


Ser Arg Ser Arg Asn Thr Thr Val Ala Asp Thr Tyr Asn Ile Thr Asp 
        755                 760                 765             


Pro Glu Glu Phe Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp 
    770                 775                 780                 


Asn Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr 
785                 790                 795                 800 


Arg Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys 
                805                 810                 815     


Ser Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala 
            820                 825                 830         


Asp Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser 
        835                 840                 845             


Ile Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu 
    850                 855                 860                 


Met Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys 
865                 870                 875                 880 


Val Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg 
                885                 890                 895     


Leu Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser 
            900                 905                 910         


Gly Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Pro Ala Lys 
        915                 920                 925             


Thr Thr Tyr Glu Asn Phe Met His Leu Ile Ile Ala Leu Pro Val Ala 
    930                 935                 940                 


Ile Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His 
945                 950                 955                 960 


Arg Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser 
                965                 970                 975     


Val Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu 
            980                 985                 990         


Trp Glu Val Ala Arg Glu Lys Ile  Thr Met Asn Arg Glu  Leu Gly Gln 
        995                 1000                 1005             


Gly Ser  Phe Gly Met Val Tyr  Glu Gly Val Ala Lys  Gly Val Val 
    1010                 1015                 1020             


Lys Asp  Glu Pro Glu Thr Arg  Val Ala Ile Lys Thr  Val Asn Glu 
    1025                 1030                 1035             


Ala Ala  Ser Met Arg Glu Arg  Ile Glu Phe Leu Asn  Glu Ala Ser 
    1040                 1045                 1050             


Val Met  Lys Glu Phe Asn Cys  His His Val Val Arg  Leu Leu Gly 
    1055                 1060                 1065             


Val Val  Ser Gln Gly Gln Pro  Thr Leu Val Ile Met  Glu Leu Met 
    1070                 1075                 1080             


Thr Arg  Gly Asp Leu Lys Ser  Tyr Leu Arg Ser Leu  Arg Pro Glu 
    1085                 1090                 1095             


Val Glu  Asn Asn Leu Val Leu  Ile Pro Pro Ser Leu  Ser Lys Met 
    1100                 1105                 1110             


Ile Gln  Met Ala Gly Glu Ile  Ala Asp Gly Met Ala  Tyr Leu Asn 
    1115                 1120                 1125             


Ala Asn  Lys Phe Val His Arg  Asp Leu Ala Ala Arg  Asn Cys Met 
    1130                 1135                 1140             


Val Ala  Glu Asp Phe Thr Val  Lys Ile Gly Asp Phe  Gly Met Thr 
    1145                 1150                 1155             


Arg Asp  Ile Tyr Glu Thr Asp  Tyr Tyr Arg Lys Gly  Gly Lys Gly 
    1160                 1165                 1170             


Leu Leu  Pro Val Arg Trp Met  Ser Pro Glu Ser Leu  Lys Asp Gly 
    1175                 1180                 1185             


Val Phe  Thr Thr His Ser Asp  Val Trp Ser Phe Gly  Val Val Leu 
    1190                 1195                 1200             


Trp Glu  Ile Ala Thr Leu Ala  Glu Gln Pro Tyr Gln  Gly Leu Ser 
    1205                 1210                 1215             


Asn Glu  Gln Val Leu Arg Phe  Val Met Glu Gly Gly  Leu Leu Asp 
    1220                 1225                 1230             


Lys Pro  Asp Asn Cys Pro Asp  Met Leu Phe Glu Leu  Met Arg Met 
    1235                 1240                 1245             


Cys Trp  Gln Tyr Asn Pro Lys  Met Arg Pro Ser Phe  Leu Glu Ile 
    1250                 1255                 1260             


Ile Gly  Ser Ile Lys Asp Glu  Met Glu Pro Ser Phe  Gln Glu Val 
    1265                 1270                 1275             


Ser Phe  Tyr Tyr Ser Glu Glu  Asn Lys Pro Pro Glu  Pro Glu Glu 
    1280                 1285                 1290             


Leu Glu  Met Glu Leu Glu Leu  Glu Pro Glu Asn Met  Glu Ser Val 
    1295                 1300                 1305             


Pro Leu  Asp Pro Ser Ala Ser  Ser Ala Ser Leu Pro  Leu Pro Glu 
    1310                 1315                 1320             


Arg His  Ser Gly His Lys Ala  Glu Asn Gly Pro Gly  Val Leu Val 
    1325                 1330                 1335             


Leu Arg  Ala Ser Phe Asp Glu  Arg Gln Pro Tyr Ala  His Met Asn 
    1340                 1345                 1350             


Gly Gly  Arg Ala Asn Glu Arg  Ala Leu Pro Leu Pro  Gln Ser Ser 
    1355                 1360                 1365             


Thr Cys  
    1370 


<210>  13
<211>  3516
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cricetulus griseus IGF1R Del1 mutant

<400>  13
atgaagtctg gctccggagg agggtccccg acctcactgt gggggctcgt gtttctctct       60

gccgcgctct cgctgtggcc gacgagtgga tgccacccag agtgcctagg cagctgccat      120

acacctgacg acaacacaac ctgtgtggcc tgccgacact actactacaa aggcgtgtgt      180

gtgcctgcct gcccacctgg cacctacagg ttcgagggct ggcgctgtgt ggaccgcgat      240

ttctgcgcca acatccccaa cgctgagagc agtgactcag atggctttgt catccacgat      300

ggcgagtgca tgcaagaatg tccctcaggc ttcatccgca acagcaccca gagcatgtac      360

tgtatcccct gtgaaggccc ctgcccaaaa gtctgtggcg atgaagaaaa gaaaacaaaa      420

accatcgact cggttacgtc ggctcagatg ctccaaggat gcaccatctt gaagggcaat      480

ttacttatta atatccggcg gggcaataac attgcctcag aacttgagaa cttcatgggg      540

ctcatcgagg tagtgactgg ctatgtgaag atccgccatt cccatgcttt ggtctccttg      600

tccttcctga agaaccttcg tctaatctta ggagaggagc agctggaagg gaactactcc      660

ttctatgtcc tggacaacca gaacttgcag cagctgtggg actggaacca ccggaacctg      720

accgtcaggt cggggaagat gtactttgct ttcaatccca agctgtgtgt ctctgaaatt      780

taccgcatgg aggaagtaac aggaacaaag ggccgccaga gcaaagggga cataaacacc      840

aggaacaatg gagagcgagc ttcctgtgaa agcgacgttc tccgtttcac ctccaccacc      900

acctcaaaga accggatcat cataacatgg caccggtacc ggcccccaga ttacagggat      960

ctcatcagct tcacggttta ctacaaggag gcacccttta aaaatgttac ggaatatgat     1020

gggcaggatg cctgtggctc caacagctgg aacatggtgg atgtggacct acctcccaac     1080

aaggaggggg agcctggcat tttactgcat gggctgaagc cctggaccca gtatgccgtc     1140

tatgtcaagg ctgtgaccct caccatggtg gaaaacgacc atatccgtgg ggccaaaagt     1200

gaaatcttgt acattcgcac caatgcttca gttccttcca ttcccctaga tgtactttcg     1260

gcctcaaact cttcttctca gctgattgtg aagtggaatc ctccaactct gcccaatggt     1320

aacttgagtt actacattgt aaggtggcag cgacagccac aggatggcta cctgtaccgg     1380

cacaactact gctccaaaga caaaataccc atcagaaagt atgcggatgg caccattgat     1440

gtggaagagg tgacagagaa tcccaagaca gaagtgtgtg gtggtgacaa agggccttgc     1500

tgtgcttgtc ccaaaactga agccgagaag caggccgaga aggaagaggc cgagtaccgc     1560

aaagtctttg agaatttcct gcacaattcc atcttcgtgc ccagacccga aaggaggcgg     1620

agagatgtca tgcaagtagc caacaccacc atgtctagcc gaagcaggaa caccacagtg     1680

gctgacacct acaatatcac agatccagaa gaactcgaga cagagtaccc tttctttgag     1740

agcagagtag ataacaagga gagaactgtc atctccaacc ttcggccttt cactttgtac     1800

cgcattgata tccacagctg caaccacgaa gccgagaagc tgggctgcag tgcctccaac     1860

tttgtctttg cgagaaccat gcctgcagaa ggagcagatg acattcctgg accagtgacc     1920

tgggagccaa gacctgaaaa ctccatcttt ttaaagtggc cagaacctga gaaccccaac     1980

ggattgattc taatgtatga aataaagtat ggatcacaag ttgaggatca gcgggaatgt     2040

gtgtccagac aggaatacag gaagtacgga ggggccaagc ttaaccggct aaacccaggg     2100

aactatacag cccggattca ggccacgtct ctctctggca atgggtcttg gacagatcct     2160

gtgttcttct atgtcccagc caagacgaca tatgagaatt tcatgcacct gataattgct     2220

ctgccggtcg ccatcctgct gattgtgggg ggactggtca tcatgctgta tgtcttccat     2280

aggaagagaa ataacagcag gttgggcaat ggagtgctgt atgcctctgt gaaccccgag     2340

tatttcagtg cagcggatgt gtacgtgccc gatgaatggg aggtagctcg agagaagatc     2400

accatgaacc gggagcttgg acaagggtcc tttgggatgg tctatgaagg agtggccaag     2460

ggagtggtca aggatgaacc tgaaaccaga gtagccatca agacagtaaa tgaggctgca     2520

agtatgcgtg aaagaatcga gtttctcaac gaggcttcag tgatgaagga gttcaactgt     2580

caccatgtgg tccggttgct gggggtggtg tcccaaggcc agcctaccct ggtcatcatg     2640

gaactaatga cacgtgggga tctcaaaagt tatctccggt ctctaaggcc agaagtggag     2700

caaaataatc tagtcctaat tcctccgagt ttaagcaaga tgatccagat ggctggagag     2760

attgcagatg gcatggctta cctcaacgcc aacaagttcg tccacagaga ccttgctgct     2820

cggaactgca tggtagctga agatttcaca gtcaaaattg gagattttgg tatgacacga     2880

gatatctacg agacagacta ctaccggaaa ggagggaagg ggctgctgcc tgtgcgctgg     2940

atgtctcctg agtccctcaa ggacggagtc ttcaccactc actcagatgt ctggtccttt     3000

ggggtcgtcc tctgggagat tgctacactg gctgagcagc cataccaagg cttgtccaat     3060

gagcaagttc ttcgcttcgt catggagggc ggccttctgg acaagccgga caattgccct     3120

gacatgctgt ttgaactcat gcgcatgtgc tggcagtaca accctaagat gaggccctcc     3180

ttcctggaga tcattggcag catcaaggat gagatggagc ccagctttca ggaggtctcc     3240

ttctactaca gcgaggagaa caagcctcct gagccagaag agctggagct ggaactggag     3300

cccgagaaca tggagagcgt accgctggac ccctcggcct cctcagtctc cctgcctctg     3360

ccagaaagac actcaggaca caaggccgag aatggcccag gccctggagt actggttctc     3420

cgtgccagtt tcgatgagcg acagccttac gctcacatga acgggggacg agccaacgag     3480

agggctttgc ctctgcccca gtcttcaacc tgctga                               3516


<210>  14
<211>  1171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cricetulus griseus IGF1R Del1 mutant

<400>  14

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Val Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Cys His 
            20                  25                  30          


Pro Glu Cys Leu Gly Ser Cys His Thr Pro Asp Asp Asn Thr Thr Cys 
        35                  40                  45              


Val Ala Cys Arg His Tyr Tyr Tyr Lys Gly Val Cys Val Pro Ala Cys 
    50                  55                  60                  


Pro Pro Gly Thr Tyr Arg Phe Glu Gly Trp Arg Cys Val Asp Arg Asp 
65                  70                  75                  80  


Phe Cys Ala Asn Ile Pro Asn Ala Glu Ser Ser Asp Ser Asp Gly Phe 
                85                  90                  95      


Val Ile His Asp Gly Glu Cys Met Gln Glu Cys Pro Ser Gly Phe Ile 
            100                 105                 110         


Arg Asn Ser Thr Gln Ser Met Tyr Cys Ile Pro Cys Glu Gly Pro Cys 
        115                 120                 125             


Pro Lys Val Cys Gly Asp Glu Glu Lys Lys Thr Lys Thr Ile Asp Ser 
    130                 135                 140                 


Val Thr Ser Ala Gln Met Leu Gln Gly Cys Thr Ile Leu Lys Gly Asn 
145                 150                 155                 160 


Leu Leu Ile Asn Ile Arg Arg Gly Asn Asn Ile Ala Ser Glu Leu Glu 
                165                 170                 175     


Asn Phe Met Gly Leu Ile Glu Val Val Thr Gly Tyr Val Lys Ile Arg 
            180                 185                 190         


His Ser His Ala Leu Val Ser Leu Ser Phe Leu Lys Asn Leu Arg Leu 
        195                 200                 205             


Ile Leu Gly Glu Glu Gln Leu Glu Gly Asn Tyr Ser Phe Tyr Val Leu 
    210                 215                 220                 


Asp Asn Gln Asn Leu Gln Gln Leu Trp Asp Trp Asn His Arg Asn Leu 
225                 230                 235                 240 


Thr Val Arg Ser Gly Lys Met Tyr Phe Ala Phe Asn Pro Lys Leu Cys 
                245                 250                 255     


Val Ser Glu Ile Tyr Arg Met Glu Glu Val Thr Gly Thr Lys Gly Arg 
            260                 265                 270         


Gln Ser Lys Gly Asp Ile Asn Thr Arg Asn Asn Gly Glu Arg Ala Ser 
        275                 280                 285             


Cys Glu Ser Asp Val Leu Arg Phe Thr Ser Thr Thr Thr Ser Lys Asn 
    290                 295                 300                 


Arg Ile Ile Ile Thr Trp His Arg Tyr Arg Pro Pro Asp Tyr Arg Asp 
305                 310                 315                 320 


Leu Ile Ser Phe Thr Val Tyr Tyr Lys Glu Ala Pro Phe Lys Asn Val 
                325                 330                 335     


Thr Glu Tyr Asp Gly Gln Asp Ala Cys Gly Ser Asn Ser Trp Asn Met 
            340                 345                 350         


Val Asp Val Asp Leu Pro Pro Asn Lys Glu Gly Glu Pro Gly Ile Leu 
        355                 360                 365             


Leu His Gly Leu Lys Pro Trp Thr Gln Tyr Ala Val Tyr Val Lys Ala 
    370                 375                 380                 


Val Thr Leu Thr Met Val Glu Asn Asp His Ile Arg Gly Ala Lys Ser 
385                 390                 395                 400 


Glu Ile Leu Tyr Ile Arg Thr Asn Ala Ser Val Pro Ser Ile Pro Leu 
                405                 410                 415     


Asp Val Leu Ser Ala Ser Asn Ser Ser Ser Gln Leu Ile Val Lys Trp 
            420                 425                 430         


Asn Pro Pro Thr Leu Pro Asn Gly Asn Leu Ser Tyr Tyr Ile Val Arg 
        435                 440                 445             


Trp Gln Arg Gln Pro Gln Asp Gly Tyr Leu Tyr Arg His Asn Tyr Cys 
    450                 455                 460                 


Ser Lys Asp Lys Ile Pro Ile Arg Lys Tyr Ala Asp Gly Thr Ile Asp 
465                 470                 475                 480 


Val Glu Glu Val Thr Glu Asn Pro Lys Thr Glu Val Cys Gly Gly Asp 
                485                 490                 495     


Lys Gly Pro Cys Cys Ala Cys Pro Lys Thr Glu Ala Glu Lys Gln Ala 
            500                 505                 510         


Glu Lys Glu Glu Ala Glu Tyr Arg Lys Val Phe Glu Asn Phe Leu His 
        515                 520                 525             


Asn Ser Ile Phe Val Pro Arg Pro Glu Arg Arg Arg Arg Asp Val Met 
    530                 535                 540                 


Gln Val Ala Asn Thr Thr Met Ser Ser Arg Ser Arg Asn Thr Thr Val 
545                 550                 555                 560 


Ala Asp Thr Tyr Asn Ile Thr Asp Pro Glu Glu Leu Glu Thr Glu Tyr 
                565                 570                 575     


Pro Phe Phe Glu Ser Arg Val Asp Asn Lys Glu Arg Thr Val Ile Ser 
            580                 585                 590         


Asn Leu Arg Pro Phe Thr Leu Tyr Arg Ile Asp Ile His Ser Cys Asn 
        595                 600                 605             


His Glu Ala Glu Lys Leu Gly Cys Ser Ala Ser Asn Phe Val Phe Ala 
    610                 615                 620                 


Arg Thr Met Pro Ala Glu Gly Ala Asp Asp Ile Pro Gly Pro Val Thr 
625                 630                 635                 640 


Trp Glu Pro Arg Pro Glu Asn Ser Ile Phe Leu Lys Trp Pro Glu Pro 
                645                 650                 655     


Glu Asn Pro Asn Gly Leu Ile Leu Met Tyr Glu Ile Lys Tyr Gly Ser 
            660                 665                 670         


Gln Val Glu Asp Gln Arg Glu Cys Val Ser Arg Gln Glu Tyr Arg Lys 
        675                 680                 685             


Tyr Gly Gly Ala Lys Leu Asn Arg Leu Asn Pro Gly Asn Tyr Thr Ala 
    690                 695                 700                 


Arg Ile Gln Ala Thr Ser Leu Ser Gly Asn Gly Ser Trp Thr Asp Pro 
705                 710                 715                 720 


Val Phe Phe Tyr Val Pro Ala Lys Thr Thr Tyr Glu Asn Phe Met His 
                725                 730                 735     


Leu Ile Ile Ala Leu Pro Val Ala Ile Leu Leu Ile Val Gly Gly Leu 
            740                 745                 750         


Val Ile Met Leu Tyr Val Phe His Arg Lys Arg Asn Asn Ser Arg Leu 
        755                 760                 765             


Gly Asn Gly Val Leu Tyr Ala Ser Val Asn Pro Glu Tyr Phe Ser Ala 
    770                 775                 780                 


Ala Asp Val Tyr Val Pro Asp Glu Trp Glu Val Ala Arg Glu Lys Ile 
785                 790                 795                 800 


Thr Met Asn Arg Glu Leu Gly Gln Gly Ser Phe Gly Met Val Tyr Glu 
                805                 810                 815     


Gly Val Ala Lys Gly Val Val Lys Asp Glu Pro Glu Thr Arg Val Ala 
            820                 825                 830         


Ile Lys Thr Val Asn Glu Ala Ala Ser Met Arg Glu Arg Ile Glu Phe 
        835                 840                 845             


Leu Asn Glu Ala Ser Val Met Lys Glu Phe Asn Cys His His Val Val 
    850                 855                 860                 


Arg Leu Leu Gly Val Val Ser Gln Gly Gln Pro Thr Leu Val Ile Met 
865                 870                 875                 880 


Glu Leu Met Thr Arg Gly Asp Leu Lys Ser Tyr Leu Arg Ser Leu Arg 
                885                 890                 895     


Pro Glu Val Glu Gln Asn Asn Leu Val Leu Ile Pro Pro Ser Leu Ser 
            900                 905                 910         


Lys Met Ile Gln Met Ala Gly Glu Ile Ala Asp Gly Met Ala Tyr Leu 
        915                 920                 925             


Asn Ala Asn Lys Phe Val His Arg Asp Leu Ala Ala Arg Asn Cys Met 
    930                 935                 940                 


Val Ala Glu Asp Phe Thr Val Lys Ile Gly Asp Phe Gly Met Thr Arg 
945                 950                 955                 960 


Asp Ile Tyr Glu Thr Asp Tyr Tyr Arg Lys Gly Gly Lys Gly Leu Leu 
                965                 970                 975     


Pro Val Arg Trp Met Ser Pro Glu Ser Leu Lys Asp Gly Val Phe Thr 
            980                 985                 990         


Thr His Ser Asp Val Trp Ser Phe  Gly Val Val Leu Trp  Glu Ile Ala 
        995                 1000                 1005             


Thr Leu  Ala Glu Gln Pro Tyr  Gln Gly Leu Ser Asn  Glu Gln Val 
    1010                 1015                 1020             


Leu Arg  Phe Val Met Glu Gly  Gly Leu Leu Asp Lys  Pro Asp Asn 
    1025                 1030                 1035             


Cys Pro  Asp Met Leu Phe Glu  Leu Met Arg Met Cys  Trp Gln Tyr 
    1040                 1045                 1050             


Asn Pro  Lys Met Arg Pro Ser  Phe Leu Glu Ile Ile  Gly Ser Ile 
    1055                 1060                 1065             


Lys Asp  Glu Met Glu Pro Ser  Phe Gln Glu Val Ser  Phe Tyr Tyr 
    1070                 1075                 1080             


Ser Glu  Glu Asn Lys Pro Pro  Glu Pro Glu Glu Leu  Glu Leu Glu 
    1085                 1090                 1095             


Leu Glu  Pro Glu Asn Met Glu  Ser Val Pro Leu Asp  Pro Ser Ala 
    1100                 1105                 1110             


Ser Ser  Val Ser Leu Pro Leu  Pro Glu Arg His Ser  Gly His Lys 
    1115                 1120                 1125             


Ala Glu  Asn Gly Pro Gly Pro  Gly Val Leu Val Leu  Arg Ala Ser 
    1130                 1135                 1140             


Phe Asp  Glu Arg Gln Pro Tyr  Ala His Met Asn Gly  Gly Arg Ala 
    1145                 1150                 1155             


Asn Glu  Arg Ala Leu Pro Leu  Pro Gln Ser Ser Thr  Cys 
    1160                 1165                 1170     


<210>  15
<211>  4116
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cricetulus griseus IGF1R H906C mutant

<400>  15
atgaagtctg gctccggagg agggtccccg acctcactgt gggggctcgt gtttctctct       60

gccgcgctct cgctgtggcc gacgagtgga gaaatttgtg ggcccggcat tgacatccgc      120

aatgactacc agcagctgaa gcgcctggaa aactgcacag tgattgaggg cttcctccac      180

atcctgctca tctccaaggc cgaggactac cgaagctacc gcttccccaa gctcacggtc      240

atcactgagt acttgctgct gtttcgagtg gccggcctcg agagcctggg agacctcttc      300

cccaacctta cggttatccg tggctggaaa ctcttctaca actacgcact ggtcatcttt      360

gagatgacca atctcaagga tattggactt tataatctga gaaacattac acggggggcc      420

atcaggattg agaagaacgc agacctctgt tacctctcca ccatagactg gtctctcatc      480

ttggatgcag tgtctaataa ctacattgtg ggcaacaagc ccccaaagga atgtggggac      540

ctgtgtccag ggaccttgga ggagaagccc atgtgtgaga agaccaccat caacaatgag      600

tacaactacc gctgctggac cacaaatcaa tgccagaaaa tgtgcccaag tgtgtgcgga      660

aagcgagcgt gcaccgagaa caacgaatgc tgccacccag agtgcctagg cagctgccat      720

acacctgacg acaacacaac ctgtgtggcc tgccgacact actactacaa aggcgtgtgt      780

gtgcctgcct gcccacctgg cacctacagg ttcgagggct ggcgctgtgt ggaccgcgat      840

ttctgcgcca acatccccaa cgctgagagc agtgactcag atggctttgt catccacgat      900

ggcgagtgca tgcaagaatg tccctcaggc ttcatccgca acagcaccca gagcatgtac      960

tgtatcccct gtgaaggccc ctgcccaaaa gtctgtggcg atgaagaaaa gaaaacaaaa     1020

accatcgact cggttacgtc ggctcagatg ctccaaggat gcaccatctt gaagggcaat     1080

ttacttatta atatccggcg gggcaataac attgcctcag aacttgagaa cttcatgggg     1140

ctcatcgagg tagtgactgg ctatgtgaag atccgccatt cccatgcttt ggtctccttg     1200

tccttcctga agaaccttcg tctaatctta ggagaggagc agctggaagg gaactactcc     1260

ttctatgtcc tggacaacca gaacttgcag cagctgtggg actggaacca ccggaacctg     1320

accgtcaggt cggggaagat gtactttgct ttcaatccca agctgtgtgt ctctgaaatt     1380

taccgcatgg aggaagtaac aggaacaaag ggccgccaga gcaaagggga cataaacacc     1440

aggaacaatg gagagcgagc ttcctgtgaa agcgacgttc tccgtttcac ctccaccacc     1500

acctcaaaga accggatcat cataacatgg caccggtacc ggcccccaga ttacagggat     1560

ctcatcagct tcacggttta ctacaaggag gcacccttta aaaatgttac ggaatatgat     1620

gggcaggatg cctgtggctc caacagctgg aacatggtgg atgtggacct acctcccaac     1680

aaggaggggg agcctggcat tttactgcat gggctgaagc cctggaccca gtatgccgtc     1740

tatgtcaagg ctgtgaccct caccatggtg gaaaacgacc atatccgtgg ggccaaaagt     1800

gaaatcttgt acattcgcac caatgcttca gttccttcca ttcccctaga tgtactttcg     1860

gcctcaaact cttcttctca gctgattgtg aagtggaatc ctccaactct gcccaatggt     1920

aacttgagtt actacattgt aaggtggcag cgacagccac aggatggcta cctgtaccgg     1980

cacaactact gctccaaaga caaaataccc atcagaaagt atgcggatgg caccattgat     2040

gtggaagagg tgacagagaa tcccaagaca gaagtgtgtg gtggtgacaa agggccttgc     2100

tgtgcttgtc ccaaaactga agccgagaag caggccgaga aggaagaggc cgagtaccgc     2160

aaagtctttg agaatttcct gcacaattcc atcttcgtgc ccagacccga aaggaggcgg     2220

agagatgtca tgcaagtagc caacaccacc atgtctagcc gaagcaggaa caccacagtg     2280

gctgacacct acaatatcac agatccagaa gaactcgaga cagagtaccc tttctttgag     2340

agcagagtag ataacaagga gagaactgtc atctccaacc ttcggccttt cactttgtac     2400

cgcattgata tccacagctg caaccacgaa gccgagaagc tgggctgcag tgcctccaac     2460

tttgtctttg cgagaaccat gcctgcagaa ggagcagatg acattcctgg accagtgacc     2520

tgggagccaa gacctgaaaa ctccatcttt ttaaagtggc cagaacctga gaaccccaac     2580

ggattgattc taatgtatga aataaagtat ggatcacaag ttgaggatca gcgggaatgt     2640

gtgtccagac aggaatacag gaagtacgga ggggccaagc ttaaccggct aaacccaggg     2700

aactatacag cccggattca ggccacgtct ctctctggca atgggtcttg gacagatcct     2760

gtgttcttct atgtcccagc caagacgaca tatgagaatt tcatgtgtct gataattgct     2820

ctgccggtcg ccatcctgct gattgtgggg ggactggtca tcatgctgta tgtcttccat     2880

aggaagagaa ataacagcag gttgggcaat ggagtgctgt atgcctctgt gaaccccgag     2940

tatttcagtg cagcggatgt gtacgtgccc gatgaatggg aggtagctcg agagaagatc     3000

accatgaacc gggagcttgg acaagggtcc tttgggatgg tctatgaagg agtggccaag     3060

ggagtggtca aggatgaacc tgaaaccaga gtagccatca agacagtaaa tgaggctgca     3120

agtatgcgtg aaagaatcga gtttctcaac gaggcttcag tgatgaagga gttcaactgt     3180

caccatgtgg tccggttgct gggggtggtg tcccaaggcc agcctaccct ggtcatcatg     3240

gaactaatga cacgtgggga tctcaaaagt tatctccggt ctctaaggcc agaagtggag     3300

caaaataatc tagtcctaat tcctccgagt ttaagcaaga tgatccagat ggctggagag     3360

attgcagatg gcatggctta cctcaacgcc aacaagttcg tccacagaga ccttgctgct     3420

cggaactgca tggtagctga agatttcaca gtcaaaattg gagattttgg tatgacacga     3480

gatatctacg agacagacta ctaccggaaa ggagggaagg ggctgctgcc tgtgcgctgg     3540

atgtctcctg agtccctcaa ggacggagtc ttcaccactc actcagatgt ctggtccttt     3600

ggggtcgtcc tctgggagat tgctacactg gctgagcagc cataccaagg cttgtccaat     3660

gagcaagttc ttcgcttcgt catggagggc ggccttctgg acaagccgga caattgccct     3720

gacatgctgt ttgaactcat gcgcatgtgc tggcagtaca accctaagat gaggccctcc     3780

ttcctggaga tcattggcag catcaaggat gagatggagc ccagctttca ggaggtctcc     3840

ttctactaca gcgaggagaa caagcctcct gagccagaag agctggagct ggaactggag     3900

cccgagaaca tggagagcgt accgctggac ccctcggcct cctcagtctc cctgcctctg     3960

ccagaaagac actcaggaca caaggccgag aatggcccag gccctggagt actggttctc     4020

cgtgccagtt tcgatgagcg acagccttac gctcacatga acgggggacg agccaacgag     4080

agggctttgc ctctgcccca gtcttcaacc tgctga                               4116


<210>  16
<211>  1371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cricetulus griseus IGF1R H906C mutant

<400>  16

Met Lys Ser Gly Ser Gly Gly Gly Ser Pro Thr Ser Leu Trp Gly Leu 
1               5                   10                  15      


Val Phe Leu Ser Ala Ala Leu Ser Leu Trp Pro Thr Ser Gly Glu Ile 
            20                  25                  30          


Cys Gly Pro Gly Ile Asp Ile Arg Asn Asp Tyr Gln Gln Leu Lys Arg 
        35                  40                  45              


Leu Glu Asn Cys Thr Val Ile Glu Gly Phe Leu His Ile Leu Leu Ile 
    50                  55                  60                  


Ser Lys Ala Glu Asp Tyr Arg Ser Tyr Arg Phe Pro Lys Leu Thr Val 
65                  70                  75                  80  


Ile Thr Glu Tyr Leu Leu Leu Phe Arg Val Ala Gly Leu Glu Ser Leu 
                85                  90                  95      


Gly Asp Leu Phe Pro Asn Leu Thr Val Ile Arg Gly Trp Lys Leu Phe 
            100                 105                 110         


Tyr Asn Tyr Ala Leu Val Ile Phe Glu Met Thr Asn Leu Lys Asp Ile 
        115                 120                 125             


Gly Leu Tyr Asn Leu Arg Asn Ile Thr Arg Gly Ala Ile Arg Ile Glu 
    130                 135                 140                 


Lys Asn Ala Asp Leu Cys Tyr Leu Ser Thr Ile Asp Trp Ser Leu Ile 
145                 150                 155                 160 


Leu Asp Ala Val Ser Asn Asn Tyr Ile Val Gly Asn Lys Pro Pro Lys 
                165                 170                 175     


Glu Cys Gly Asp Leu Cys Pro Gly Thr Leu Glu Glu Lys Pro Met Cys 
            180                 185                 190         


Glu Lys Thr Thr Ile Asn Asn Glu Tyr Asn Tyr Arg Cys Trp Thr Thr 
        195                 200                 205             


Asn Gln Cys Gln Lys Met Cys Pro Ser Val Cys Gly Lys Arg Ala Cys 
    210                 215                 220                 


Thr Glu Asn Asn Glu Cys Cys His Pro Glu Cys Leu Gly Ser Cys His 
225                 230                 235                 240 


Thr Pro Asp Asp Asn Thr Thr Cys Val Ala Cys Arg His Tyr Tyr Tyr 
                245                 250                 255     


Lys Gly Val Cys Val Pro Ala Cys Pro Pro Gly Thr Tyr Arg Phe Glu 
            260                 265                 270         


Gly Trp Arg Cys Val Asp Arg Asp Phe Cys Ala Asn Ile Pro Asn Ala 
        275                 280                 285             


Glu Ser Ser Asp Ser Asp Gly Phe Val Ile His Asp Gly Glu Cys Met 
    290                 295                 300                 


Gln Glu Cys Pro Ser Gly Phe Ile Arg Asn Ser Thr Gln Ser Met Tyr 
305                 310                 315                 320 


Cys Ile Pro Cys Glu Gly Pro Cys Pro Lys Val Cys Gly Asp Glu Glu 
                325                 330                 335     


Lys Lys Thr Lys Thr Ile Asp Ser Val Thr Ser Ala Gln Met Leu Gln 
            340                 345                 350         


Gly Cys Thr Ile Leu Lys Gly Asn Leu Leu Ile Asn Ile Arg Arg Gly 
        355                 360                 365             


Asn Asn Ile Ala Ser Glu Leu Glu Asn Phe Met Gly Leu Ile Glu Val 
    370                 375                 380                 


Val Thr Gly Tyr Val Lys Ile Arg His Ser His Ala Leu Val Ser Leu 
385                 390                 395                 400 


Ser Phe Leu Lys Asn Leu Arg Leu Ile Leu Gly Glu Glu Gln Leu Glu 
                405                 410                 415     


Gly Asn Tyr Ser Phe Tyr Val Leu Asp Asn Gln Asn Leu Gln Gln Leu 
            420                 425                 430         


Trp Asp Trp Asn His Arg Asn Leu Thr Val Arg Ser Gly Lys Met Tyr 
        435                 440                 445             


Phe Ala Phe Asn Pro Lys Leu Cys Val Ser Glu Ile Tyr Arg Met Glu 
    450                 455                 460                 


Glu Val Thr Gly Thr Lys Gly Arg Gln Ser Lys Gly Asp Ile Asn Thr 
465                 470                 475                 480 


Arg Asn Asn Gly Glu Arg Ala Ser Cys Glu Ser Asp Val Leu Arg Phe 
                485                 490                 495     


Thr Ser Thr Thr Thr Ser Lys Asn Arg Ile Ile Ile Thr Trp His Arg 
            500                 505                 510         


Tyr Arg Pro Pro Asp Tyr Arg Asp Leu Ile Ser Phe Thr Val Tyr Tyr 
        515                 520                 525             


Lys Glu Ala Pro Phe Lys Asn Val Thr Glu Tyr Asp Gly Gln Asp Ala 
    530                 535                 540                 


Cys Gly Ser Asn Ser Trp Asn Met Val Asp Val Asp Leu Pro Pro Asn 
545                 550                 555                 560 


Lys Glu Gly Glu Pro Gly Ile Leu Leu His Gly Leu Lys Pro Trp Thr 
                565                 570                 575     


Gln Tyr Ala Val Tyr Val Lys Ala Val Thr Leu Thr Met Val Glu Asn 
            580                 585                 590         


Asp His Ile Arg Gly Ala Lys Ser Glu Ile Leu Tyr Ile Arg Thr Asn 
        595                 600                 605             


Ala Ser Val Pro Ser Ile Pro Leu Asp Val Leu Ser Ala Ser Asn Ser 
    610                 615                 620                 


Ser Ser Gln Leu Ile Val Lys Trp Asn Pro Pro Thr Leu Pro Asn Gly 
625                 630                 635                 640 


Asn Leu Ser Tyr Tyr Ile Val Arg Trp Gln Arg Gln Pro Gln Asp Gly 
                645                 650                 655     


Tyr Leu Tyr Arg His Asn Tyr Cys Ser Lys Asp Lys Ile Pro Ile Arg 
            660                 665                 670         


Lys Tyr Ala Asp Gly Thr Ile Asp Val Glu Glu Val Thr Glu Asn Pro 
        675                 680                 685             


Lys Thr Glu Val Cys Gly Gly Asp Lys Gly Pro Cys Cys Ala Cys Pro 
    690                 695                 700                 


Lys Thr Glu Ala Glu Lys Gln Ala Glu Lys Glu Glu Ala Glu Tyr Arg 
705                 710                 715                 720 


Lys Val Phe Glu Asn Phe Leu His Asn Ser Ile Phe Val Pro Arg Pro 
                725                 730                 735     


Glu Arg Arg Arg Arg Asp Val Met Gln Val Ala Asn Thr Thr Met Ser 
            740                 745                 750         


Ser Arg Ser Arg Asn Thr Thr Val Ala Asp Thr Tyr Asn Ile Thr Asp 
        755                 760                 765             


Pro Glu Glu Leu Glu Thr Glu Tyr Pro Phe Phe Glu Ser Arg Val Asp 
    770                 775                 780                 


Asn Lys Glu Arg Thr Val Ile Ser Asn Leu Arg Pro Phe Thr Leu Tyr 
785                 790                 795                 800 


Arg Ile Asp Ile His Ser Cys Asn His Glu Ala Glu Lys Leu Gly Cys 
                805                 810                 815     


Ser Ala Ser Asn Phe Val Phe Ala Arg Thr Met Pro Ala Glu Gly Ala 
            820                 825                 830         


Asp Asp Ile Pro Gly Pro Val Thr Trp Glu Pro Arg Pro Glu Asn Ser 
        835                 840                 845             


Ile Phe Leu Lys Trp Pro Glu Pro Glu Asn Pro Asn Gly Leu Ile Leu 
    850                 855                 860                 


Met Tyr Glu Ile Lys Tyr Gly Ser Gln Val Glu Asp Gln Arg Glu Cys 
865                 870                 875                 880 


Val Ser Arg Gln Glu Tyr Arg Lys Tyr Gly Gly Ala Lys Leu Asn Arg 
                885                 890                 895     


Leu Asn Pro Gly Asn Tyr Thr Ala Arg Ile Gln Ala Thr Ser Leu Ser 
            900                 905                 910         


Gly Asn Gly Ser Trp Thr Asp Pro Val Phe Phe Tyr Val Pro Ala Lys 
        915                 920                 925             


Thr Thr Tyr Glu Asn Phe Met His Leu Ile Ile Ala Leu Pro Val Ala 
    930                 935                 940                 


Ile Leu Leu Ile Val Gly Gly Leu Val Ile Met Leu Tyr Val Phe His 
945                 950                 955                 960 


Arg Lys Arg Asn Asn Ser Arg Leu Gly Asn Gly Val Leu Tyr Ala Ser 
                965                 970                 975     


Val Asn Pro Glu Tyr Phe Ser Ala Ala Asp Val Tyr Val Pro Asp Glu 
            980                 985                 990         


Trp Glu Val Ala Arg Glu Lys Ile  Thr Met Asn Arg Glu  Leu Gly Gln 
        995                 1000                 1005             


Gly Ser  Phe Gly Met Val Tyr  Glu Gly Val Ala Lys  Gly Val Val 
    1010                 1015                 1020             


Lys Asp  Glu Pro Glu Thr Arg  Val Ala Ile Lys Thr  Val Asn Glu 
    1025                 1030                 1035             


Ala Ala  Ser Met Arg Glu Arg  Ile Glu Phe Leu Asn  Glu Ala Ser 
    1040                 1045                 1050             


Val Met  Lys Glu Phe Asn Cys  His His Val Val Arg  Leu Leu Gly 
    1055                 1060                 1065             


Val Val  Ser Gln Gly Gln Pro  Thr Leu Val Ile Met  Glu Leu Met 
    1070                 1075                 1080             


Thr Arg  Gly Asp Leu Lys Ser  Tyr Leu Arg Ser Leu  Arg Pro Glu 
    1085                 1090                 1095             


Val Glu  Gln Asn Asn Leu Val  Leu Ile Pro Pro Ser  Leu Ser Lys 
    1100                 1105                 1110             


Met Ile  Gln Met Ala Gly Glu  Ile Ala Asp Gly Met  Ala Tyr Leu 
    1115                 1120                 1125             


Asn Ala  Asn Lys Phe Val His  Arg Asp Leu Ala Ala  Arg Asn Cys 
    1130                 1135                 1140             


Met Val  Ala Glu Asp Phe Thr  Val Lys Ile Gly Asp  Phe Gly Met 
    1145                 1150                 1155             


Thr Arg  Asp Ile Tyr Glu Thr  Asp Tyr Tyr Arg Lys  Gly Gly Lys 
    1160                 1165                 1170             


Gly Leu  Leu Pro Val Arg Trp  Met Ser Pro Glu Ser  Leu Lys Asp 
    1175                 1180                 1185             


Gly Val  Phe Thr Thr His Ser  Asp Val Trp Ser Phe  Gly Val Val 
    1190                 1195                 1200             


Leu Trp  Glu Ile Ala Thr Leu  Ala Glu Gln Pro Tyr  Gln Gly Leu 
    1205                 1210                 1215             


Ser Asn  Glu Gln Val Leu Arg  Phe Val Met Glu Gly  Gly Leu Leu 
    1220                 1225                 1230             


Asp Lys  Pro Asp Asn Cys Pro  Asp Met Leu Phe Glu  Leu Met Arg 
    1235                 1240                 1245             


Met Cys  Trp Gln Tyr Asn Pro  Lys Met Arg Pro Ser  Phe Leu Glu 
    1250                 1255                 1260             


Ile Ile  Gly Ser Ile Lys Asp  Glu Met Glu Pro Ser  Phe Gln Glu 
    1265                 1270                 1275             


Val Ser  Phe Tyr Tyr Ser Glu  Glu Asn Lys Pro Pro  Glu Pro Glu 
    1280                 1285                 1290             


Glu Leu  Glu Leu Glu Leu Glu  Pro Glu Asn Met Glu  Ser Val Pro 
    1295                 1300                 1305             


Leu Asp  Pro Ser Ala Ser Ser  Val Ser Leu Pro Leu  Pro Glu Arg 
    1310                 1315                 1320             


His Ser  Gly His Lys Ala Glu  Asn Gly Pro Gly Pro  Gly Val Leu 
    1325                 1330                 1335             


Val Leu  Arg Ala Ser Phe Asp  Glu Arg Gln Pro Tyr  Ala His Met 
    1340                 1345                 1350             


Asn Gly  Gly Arg Ala Asn Glu  Arg Ala Leu Pro Leu  Pro Gln Ser 
    1355                 1360                 1365             


Ser Thr  Cys 
    1370     


