                         SEQUENCE LISTING

<110>  NEUVOGEN, INC.
 
<120>  COLORECTAL CANCER TUMOR CELL VACCINES

<130>  33193/57305

<150>  US 63/196,075
<151>  2021-06-02

<150>  US 63/108,731
<151>  2020-11-02

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
atgatcgaaa catacaacca aacttctccc cgatctgcgg ccactggact gcccatcagc       60

atgaaaattt ttatgtattt acttactgtt tttcttatca cccagatgat tgggtcagca      120

ctttttgctg tgtatcttca tagaaggttg gacaagatag aagatgaaag gaatcttcat      180

gaagattttg tattcatgaa aacgatacag agatgcaaca caggagaaag atccttatcc      240

ttactgaact gtgaggagat taaaagccag tttgaaggct ttgtgaagga tataatgtta      300

aacaaagagg agacgaagaa agaaaacagc tttgaaatgc ctcgtggtga agaggatagt      360

caaattgcgg cacatgtcat aagtgaggcc agcagtaaaa caacatctgt gttacagtgg      420

gctgaaaaag gatactacac catgagcaac aacttggtaa ccctggaaaa tgggaaacag      480

ctgaccgtta aaagacaagg actctattat atctatgccc aagtcacctt ctgttccaat      540

cgggaagctt cgagtcaagc tccatttata gccagcctct gcctaaagtc ccccggtaga      600

ttcgagagaa tcttactcag agctgcaaat acccacagtt ccgccaaacc ttgcgggcaa      660

caatccattc acttgggagg agtatttgaa ttgcaaccag gtgcttcggt gtttgtcaat      720

gtgactgatc caagccaagt gagccatggc actggcttca cgtcctttgg cttactcaaa      780

ctctga                                                                 786


<210>  2
<211>  785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
tgatcgaaac ctacaaccag acctcaccac gaagtgccgc caccggactg cctattagta       60

tgaaaatctt tatgtacctg ctgacagtgt tcctgatcac ccagatgatc ggctccgccc      120

tgtttgccgt gtacctgcac cggagactgg acaagatcga ggatgagcgg aacctgcacg      180

aggacttcgt gtttatgaag accatccagc ggtgcaacac aggcgagaga agcctgtccc      240

tgctgaattg tgaggagatc aagagccagt tcgagggctt tgtgaaggac atcatgctga      300

acaaggagga gacaaagaag gagaacagct tcgagatgcc cagaggcgag gaggattccc      360

agatcgccgc ccacgtgatc tctgaggcca gctccaagac cacaagcgtg ctgcagtggg      420

ccgagaaggg ctactatacc atgtctaaca atctggtgac actggagaac ggcaagcagc      480

tgaccgtgaa gaggcagggc ctgtactata tctatgccca ggtgacattc tgcagcaatc      540

gcgaggcctc tagccaggcc ccctttatcg ccagcctgtg cctgaagagc cctggcaggt      600

tcgagcgcat cctgctgaga gccgccaaca cccactcctc tgccaagcca tgcggacagc      660

agtcaatcca cctgggaggc gtgttcgagc tgcagccagg agcaagcgtg ttcgtgaatg      720

tgactgaccc atcacaggtg tctcacggca ctggattcac atcatttgga ctgctgaaac      780

tgtga                                                                  785


<210>  3
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Pro Arg Gly Glu Glu Asp Ser Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  4
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
atggctcagc atggggctat gggggccttc agggctctgt gcggactggc tctgctgtgc       60

gctctgtcac tggggcagag accaacagga ggaccaggat gcggacctgg caggctgctg      120

ctgggcaccg gcacagacgc aaggtgctgt agagtgcaca ccacaaggtg ctgtcgcgac      180

taccctggcg aggagtgctg ttctgagtgg gattgcatgt gcgtgcagcc agagtttcac      240

tgtggcgatc cctgctgtac cacatgccgc caccacccat gtccacctgg acagggagtg      300

cagtctcagg gcaagttcag ctttggcttc cagtgcatcg actgtgcaag cggcaccttt      360

tccggaggac acgagggaca ctgcaagccc tggaccgatt gtacacagtt tggcttcctg      420

accgtgttcc ctggcaacaa gacacacaat gccgtgtgcg tgcctggctc cccaccagca      480

gagcccctgg gctggctgac cgtggtgctg ctggccgtgg cagcatgcgt gctgctgctg      540

acaagcgccc agctgggact gcacatctgg cagctgcggt cccagtgtat gtggccaaga      600

gagacccagc tgctgctgga ggtgcctcca tccacagagg acgcccggtc ttgccagttc      660

cccgaagagg agagggggga aagaagtgcc gaagaaaagg gaaggctggg agacctgtgg      720

gtg                                                                    723


<210>  5
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  6
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6
atgtggctgc agagcctgct gctcttgggc actgtggcct gcagcatctc tgcacccgcc       60

cgctcgccca gccccagcac gcagccctgg gagcatgtga atgccatcca ggaggcccgg      120

cgtctcctga acctgagtag agacactgct gctgagatga atgaaacagt agaagtcatc      180

tcagaaatgt ttgacctcca ggagccgacc tgcctacaga cccgcctgga gctgtacaag      240

cagggcctgc ggggcagcct caccaagctc aagggcccct tgaccatgat ggccagccac      300

tacaagcagc actgccctcc aaccccggaa acttcctgtg caacccagat tatcaccttt      360

gaaagtttca aagagaacct gaaggacttt ctgcttgtca tcccctttga ctgctgggag      420

ccagtccagg agtga                                                       435


<210>  7
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atgtggctgc agtctctgct gctgctgggc accgtcgcct gttctatttc cgcacccgct       60

cgctcccctt ctccctcaac tcagccttgg gagcacgtga acgccatcca ggaggcccgg      120

agactgctga atctgtcccg ggacaccgcc gccgagatga acgagacagt ggaagtgatc      180

tctgagatgt tcgatctgca ggagcccacc tgcctgcaga caaggctgga gctgtacaag      240

cagggcctgc gcggctctct gaccaagctg aagggcccac tgacaatgat ggccagccac      300

tataagcagc actgcccccc tacccccgag acaagctgtg ccacccagat catcacattc      360

gagtccttta aggagaacct gaaggacttt ctgctggtca ttccatttga ttgttgggag      420

cccgtgcagg agtga                                                       435


<210>  8
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


<210>  9
<211>  1710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
atgtgccatc agcaactggt tatatcttgg ttcagtctcg tctttctcgc gtcacccttg       60

gtcgctatct gggagcttaa aaaagatgtc tacgtcgttg aacttgattg gtaccctgat      120

gctccggggg aaatggtggt tttgacttgc gatacgccag aagaggatgg cataacgtgg      180

acactggacc agtcttcaga ggttctcggg tctggtaaga cactcactat acaggtgaag      240

gagtttggtg acgcaggaca atatacttgc cataaaggcg gcgaggtgct ctcccatagc      300

cttctgctcc ttcataaaaa agaggacggg atatggtcaa ctgacattct gaaggatcag      360

aaagaaccga agaacaaaac tttcctcaga tgcgaggcaa agaactattc aggccgcttt      420

acttgctggt ggctcactac catcagcact gacctcactt tcagcgtcaa gagcagtaga      480

ggctcaagtg acccacaagg ggttacatgc ggggccgcta cgttgtctgc cgagcgagtc      540

aggggagata ataaggaata tgagtatagc gttgaatgcc aagaagattc agcctgccca      600

gccgcagaag agagtcttcc catagaagtt atggtggacg cagttcataa actgaagtat      660

gagaactata catcttcctt ctttattcgc gatatcataa agcctgatcc tccgaaaaac      720

ttgcaactca agccgttgaa gaatagccga caggtcgagg tctcttggga gtatccagat      780

acgtggtcta ccccgcactc ctatttcagt ctcaccttct gtgtgcaggt gcaggggaaa      840

agtaagcggg aaaaaaagga ccgggtattt actgataaga cctccgctac agtgatttgt      900

agaaagaacg cctctatcag cgtgagagcc caggatagat attattctag tagttggtct      960

gagtgggcct ccgtcccttg ttccggaagc ggagccacga acttctctct gttaaagcaa     1020

gcaggagatg ttgaagaaaa ccccgggcct atgtgtccag cgcgcagcct cctccttgtg     1080

gctaccctgg tcctcctgga ccacctcagt ttggcccgaa acctgccggt cgctacaccc     1140

gatcctggaa tgtttccctg ccttcatcac agccagaatc tgctgagggc agtcagtaac     1200

atgctgcaga aggcgcggca aactctggag ttctatccat gtacctccga ggaaattgat     1260

cacgaggaca ttactaagga taaaacaagt acagtagaag cctgtttgcc tcttgagctc     1320

actaaaaatg agtcatgctt gaacagtcga gagacgagtt ttatcactaa cggttcatgc     1380

ttggcgtcca ggaagacaag ctttatgatg gcgctctgcc tgtcttctat atatgaagac     1440

cttaaaatgt accaagttga gtttaagacc atgaacgcca aacttttgat ggaccccaag     1500

aggcagatct tccttgatca gaatatgttg gcggtgatcg atgaacttat gcaagctttg     1560

aacttcaaca gtgagacagt gcctcagaaa agttccttgg aggaaccgga cttctataag     1620

accaagatca aactgtgcat tttgctgcat gcatttagaa ttcgagccgt tacaatcgac     1680

cgggtgatgt catatttgaa tgcatcataa                                      1710


<210>  10
<211>  569
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Ser Gly Ala Thr Asn Phe Ser 
                325                 330                 335     


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Cys 
            340                 345                 350         


Pro Ala Arg Ser Leu Leu Leu Val Ala Thr Leu Val Leu Leu Asp His 
        355                 360                 365             


Leu Ser Leu Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
    370                 375                 380                 


Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
385                 390                 395                 400 


Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
                405                 410                 415     


Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
            420                 425                 430         


Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
        435                 440                 445             


Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
    450                 455                 460                 


Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
465                 470                 475                 480 


Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
                485                 490                 495     


Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
            500                 505                 510         


Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
        515                 520                 525             


Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
    530                 535                 540                 


Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
545                 550                 555                 560 


Arg Val Met Ser Tyr Leu Asn Ala Ser 
                565                 


<210>  11
<211>  402
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
atgtatagga tgcagctgct gtcatgtatc gcactgtccc tggcactggt gactaactct       60

aactgggtga atgtgatctc cgacctgaag aagatcgagg acctgatcca gtctatgcac      120

atcgatgcca ccctgtacac agagtccgac gtgcacccct cttgcaaggt gaccgccatg      180

aagtgtttcc tgctggagct gcaggtcatc agcctggaga gcggcgacgc atccatccac      240

gataccgtgg agaacctgat catcctggcc aacaatagcc tgagctccaa cggcaatgtg      300

acagagtccg gctgcaagga gtgtgaggag ctggaggaga agaatatcaa agagttcctg      360

cagtcattcg tccatatcgt ccagatgttt atcaatacca gt                         402


<210>  12
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            20                  25                  30          


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        35                  40                  45              


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
65                  70                  75                  80  


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
                85                  90                  95      


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser 
    130                 


<210>  13
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
atgtgccatc agcagctggt cattagttgg tttagcctgg tctttctggc ctcacccctg       60

gtcgcaatct gggaactgaa gaaggacgtg tacgtggtgg agctggactg gtatccagat      120

gcaccaggag agatggtggt gctgacctgc gacacacctg aggaggatgg catcacctgg      180

acactggatc agagctccga ggtgctgggc agcggcaaga ccctgacaat ccaggtgaag      240

gagttcggcg acgccggcca gtacacatgt cacaagggcg gcgaggtgct gtcccactct      300

ctgctgctgc tgcacaagaa ggaggacggc atctggtcca cagacatcct gaaggatcag      360

aaggagccaa agaacaagac cttcctgcgg tgcgaggcca agaattatag cggccggttc      420

acctgttggt ggctgaccac aatctccacc gatctgacat tttctgtgaa gtctagcagg      480

ggctcctctg acccccaggg agtgacatgc ggagcagcca ccctgagcgc cgagcgggtg      540

agaggcgata acaaggagta cgagtattct gtggagtgcc aggaggacag cgcctgtcca      600

gcagcagagg agtccctgcc tatcgaagtg atggtggatg ccgtgcacaa gctgaagtac      660

gagaattata caagctcctt ctttatcagg gacatcatca agccagatcc ccctaagaac      720

ctgcagctga agcccctgaa gaatagccgc caggtggagg tgtcctggga gtaccctgac      780

acctggtcca caccacactc ttatttcagc ctgacctttt gcgtgcaggt gcagggcaag      840

agcaagaggg agaagaagga ccgcgtgttc accgataaga catccgccac cgtgatctgt      900

cggaagaacg ccagcatctc cgtgagggcc caggatcgct actattctag ctcctggagc      960

gagtgggcct ccgtgccatg ctctggagga ggaggcagcg gcggaggagg ctccggaggc     1020

ggcggctctg gcggcggcgg ctccctgggc tctcgggccg tgatgctgct gctgctgctg     1080

ccctggaccg cacagggaag agccgtgcca ggaggctcta gcccagcatg gacacagtgc     1140

cagcagctgt cccagaagct gtgcaccctg gcatggtctg cccaccctct ggtgggccac     1200

atggacctga gagaggaggg cgatgaggag accacaaacg acgtgcctca catccagtgc     1260

ggcgacggct gtgatccaca gggcctgagg gacaattctc agttctgtct gcagcgcatc     1320

caccagggcc tgatcttcta cgagaagctg ctgggcagcg atatctttac aggagagccc     1380

agcctgctgc ctgactcccc agtgggacag ctgcacgcct ctctgctggg cctgagccag     1440

ctgctgcagc cagagggaca ccactgggag acccagcaga tcccttctct gagcccatcc     1500

cagccttggc agcggctgct gctgcggttc aagatcctga gaagcctgca ggcattcgtc     1560

gcagtcgcag ccagggtgtt cgcccacgga gccgctactc tgagccca                  1608


<210>  14
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      


Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          


Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              


Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  


Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  


Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      


Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         


Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             


Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 


Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 


Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     


Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         


Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             


Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 


Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 


Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     


Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         


Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             


Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 


Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 


Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gly Ser Arg 
            340                 345                 350         


Ala Val Met Leu Leu Leu Leu Leu Pro Trp Thr Ala Gln Gly Arg Ala 
        355                 360                 365             


Val Pro Gly Gly Ser Ser Pro Ala Trp Thr Gln Cys Gln Gln Leu Ser 
    370                 375                 380                 


Gln Lys Leu Cys Thr Leu Ala Trp Ser Ala His Pro Leu Val Gly His 
385                 390                 395                 400 


Met Asp Leu Arg Glu Glu Gly Asp Glu Glu Thr Thr Asn Asp Val Pro 
                405                 410                 415     


His Ile Gln Cys Gly Asp Gly Cys Asp Pro Gln Gly Leu Arg Asp Asn 
            420                 425                 430         


Ser Gln Phe Cys Leu Gln Arg Ile His Gln Gly Leu Ile Phe Tyr Glu 
        435                 440                 445             


Lys Leu Leu Gly Ser Asp Ile Phe Thr Gly Glu Pro Ser Leu Leu Pro 
    450                 455                 460                 


Asp Ser Pro Val Gly Gln Leu His Ala Ser Leu Leu Gly Leu Ser Gln 
465                 470                 475                 480 


Leu Leu Gln Pro Glu Gly His His Trp Glu Thr Gln Gln Ile Pro Ser 
                485                 490                 495     


Leu Ser Pro Ser Gln Pro Trp Gln Arg Leu Leu Leu Arg Phe Lys Ile 
            500                 505                 510         


Leu Arg Ser Leu Gln Ala Phe Val Ala Val Ala Ala Arg Val Phe Ala 
        515                 520                 525             


His Gly Ala Ala Thr Leu Ser Pro 
    530                 535     


<210>  15
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
atgaggctgc tgattctggc actgctgggc atctgctctc tgaccgctta catcgtggaa       60

ggagtcggct ctgaagtctc tgacaagcgc acatgcgtgt ctctgaccac acagcgcctg      120

cccgtgagcc ggatcaagac ctacacaatc accgagggca gcctgagagc cgtgatcttc      180

atcacaaaga ggggcctgaa ggtgtgcgcc gaccctcagg caacctgggt gcgggacgtg      240

gtgagaagca tggataggaa gtccaacacc cggaacaata tgatccagac aaaacccaca      300

ggaacccagc agagcactaa tacagccgtg acactgaccg gg                         342


<210>  16
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Arg Leu Leu Ile Leu Ala Leu Leu Gly Ile Cys Ser Leu Thr Ala 
1               5                   10                  15      


Tyr Ile Val Glu Gly Val Gly Ser Glu Val Ser Asp Lys Arg Thr Cys 
            20                  25                  30          


Val Ser Leu Thr Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr 
        35                  40                  45              


Thr Ile Thr Glu Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg 
    50                  55                  60                  


Gly Leu Lys Val Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val 
65                  70                  75                  80  


Val Arg Ser Met Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln 
                85                  90                  95      


Thr Lys Pro Thr Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu 
            100                 105                 110         


Thr Gly 
        


<210>  17
<211>  2965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
agagtctgag ctgtggctgc ggttcaaaga actgaccaac gagatgatcg tgaccaagaa       60

cggcagacgg atgttccccg tgctgaaagt gaacgtgtcc ggactggacc ccaacgccat      120

gtacagcttt ctgctggact tcgtggtggc cgacaaccac agatggaaat acgtgaacgg      180

cgagtgggtg ccaggcggaa aacctcaact gcaagcccct agctgcgtgt acattcaccc      240

tgacagcccc aatttcggcg cccactggat gaaggcccct gtgtccttca gcaaagtgaa      300

gctgaccaac aagctgaacg gcggaggcca gatcatgctg aacagcctgc acaaatacga      360

gcccagaatc cacatcgtca gagtcggcgg accccagaga atgatcacca gccactgctt      420

ccccgagaca cagtttatcg ccgtgaccgc ctaccagaac gaggaaatca ccacactgaa      480

gatcaagtac aaccccttcg ccaaggcctt cctggacgcc aaagagcgga gcgaccacaa      540

agagatgatc aaagagcccg gcgacagcca gcagccaggc tattctcaat ggggatggct      600

gctgccaggc accagcacat tgtgccctcc agccaatcct cacagccagt ttggaggcgc      660

cctgagcctg tctagcaccc acagctacga cagatacccc acactgcgga gccacagaag      720

cagcccctat ccttctcctt acgctcaccg gaacaacagc cccacctaca gcgataatag      780

ccccgcctgt ctgagcatgc tgcagtccca cgataactgg tccagcctga gaatgcctgc      840

tcacccttcc atgctgcccg tgtctcacaa tgcctctcca cctaccagca gctctcagta      900

ccctagcctt tggagcgtgt ccaatggcgc cgtgacactg ggatctcagg cagccgctgt      960

gtctaatgga ctgggagccc agttcttcag aggcagccct gctcactaca cccctctgac     1020

acatcctgtg tctgccccta gcagcagcgg cttccctatg tataagggcg ctgccgccgc     1080

taccgacatc gtggattctc agtatgatgc cgccgcacag ggacacctga tcgcctcttg     1140

gacacctgtg tctccacctt ccatgagagg cagaaagcgg agaagcgact tcctgctgct     1200

gcagaaccct gcctctacct gtgtgcctga accagcctct cagcacaccc tgagatctgg     1260

ccctggatgt ctccagcagc ctgaacagca gggcgttaga gatcctggcg gaatctgggc     1320

caaactggga gctgccgaag cctctgccga atgtctgcag ggcagaagaa gcagaggcgc     1380

cagcggatct gaacctcacc agatgggaag cgacgtgcac gacctgaatg ctctgttgcc     1440

tgccgtgcca tctcttggcg gaggcggagg atgtgctttg cctgtttctg gtgctgccca     1500

gtgggctccc gtgctggatt ttgctcctcc tggcgcttct gcctatggct ctcttggagg     1560

acctgctcct ccaccagctc cacctccacc gccgcctcca ccacctcaca gctttatcaa     1620

gcaagagccc tcctggggcg gagccgagcc tcacgaaaaa cagtgtctga gcgccttcac     1680

cgtgcacttt ttcggccagt ttaccggcac cgtgggcgcc tgtagatacg gcccttttgg     1740

accaccacca cctagccagg cttctagcgg acaggccaga atgttcccca acgctcctta     1800

cctgcctagc tgcctggaaa gccagcctac catcagaaac cagggcttca gcaccgtgac     1860

cttcgacggc atgcctagct atggccacac accatctcac cacgccgctc agttccccaa     1920

tcacagcttc aagcacgagg accctatggg ccagcaggga tctctgggag agcagcagta     1980

tagcgtgcca cctcctgtgt acggctgtca cacccctacc gatagctgca caggcaatca     2040

ggctctgctg ctgaggatgc ctttcagcag cgacaacctg taccagatga caagccagct     2100

ggaatgcatg atttggaacc agatgaacct gggcgccact ctgaaaggcg tggccgctgg     2160

atctagcagc tccgtgaaat ggacagccgg ccagagcaat cactccaccg gctacgagag     2220

cgacaatcac accatgccta tcctgtgtgg ggcccagtac cggattcaca cacacggcgt     2280

gttcaggggc attcaggatg tgcgaagagt gcctggcgtg gcccctacac ttgtgggatc     2340

tgccagcgaa accagcgaga agcacccctt catgtgcgcc tatccaggct gcaacaagcg     2400

gtacttcaag ctgagccacc tgaagatgca cagccggaag cacacaggcg agaagctgta     2460

ccagtgcgac ttcaaggact gcgagcggag attcagctgc agcgaccagc tgaagagaca     2520

ccagagaagg cacaccggcg tgaagccctt tcagtgcaag acctgccagc ggaccttctc     2580

ctggtccaac cacctgaaaa cccacacaag aacccacacc ggcaagacca tcgagaagcc     2640

cttcagctgt agatggccca gctgccagaa gaagttcgcc cggtctaacg agctggtgca     2700

tcaccacaac atgcaccaga ggaacatgac caaactgcag ctggtgctga ggggaagaaa     2760

gaggcggtcc accgagtaca agctggtggt tgttggagcc gatggcgtgg gaaagagcgc     2820

cctgacaatt cagctgatcc agaaccactt cgtgcgcggc agaaagagaa gatctacaga     2880

gtataagctc gtggtcgtgg gcgctgtcgg agtgggaaaa tctgccctga ccatccaact     2940

cattcagaat cactttgtgt gatga                                           2965


<210>  18
<211>  1033
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Met Ser Ser Pro Gly Thr Glu Ser Ala Gly Lys Ser Leu Gln Tyr Arg 
1               5                   10                  15      


Val Asp His Leu Leu Ser Ala Val Glu Asn Glu Leu Gln Ala Gly Ser 
            20                  25                  30          


Glu Lys Gly Asp Pro Thr Glu His Glu Leu Arg Val Gly Leu Glu Glu 
        35                  40                  45              


Ser Glu Leu Trp Leu Arg Phe Lys Glu Leu Thr Asn Glu Met Ile Val 
    50                  55                  60                  


Thr Lys Asn Gly Arg Arg Met Phe Pro Val Leu Lys Val Asn Val Ser 
65                  70                  75                  80  


Gly Leu Asp Pro Asn Ala Met Tyr Ser Phe Leu Leu Asp Phe Val Val 
                85                  90                  95      


Ala Asp Asn His Arg Trp Lys Tyr Val Asn Gly Glu Trp Val Pro Gly 
            100                 105                 110         


Gly Lys Pro Gln Leu Gln Ala Pro Ser Cys Val Tyr Ile His Pro Asp 
        115                 120                 125             


Ser Pro Asn Phe Gly Ala His Trp Met Lys Ala Pro Val Ser Phe Ser 
    130                 135                 140                 


Lys Val Lys Leu Thr Asn Lys Leu Asn Gly Gly Gly Gln Ile Met Leu 
145                 150                 155                 160 


Asn Ser Leu His Lys Tyr Glu Pro Arg Ile His Ile Val Arg Val Gly 
                165                 170                 175     


Gly Pro Gln Arg Met Ile Thr Ser His Cys Phe Pro Glu Thr Gln Phe 
            180                 185                 190         


Ile Ala Val Thr Ala Tyr Gln Asn Glu Glu Ile Thr Thr Leu Lys Ile 
        195                 200                 205             


Lys Tyr Asn Pro Phe Ala Lys Ala Phe Leu Asp Ala Lys Glu Arg Ser 
    210                 215                 220                 


Asp His Lys Glu Met Ile Lys Glu Pro Gly Asp Ser Gln Gln Pro Gly 
225                 230                 235                 240 


Tyr Ser Gln Trp Gly Trp Leu Leu Pro Gly Thr Ser Thr Leu Cys Pro 
                245                 250                 255     


Pro Ala Asn Pro His Ser Gln Phe Gly Gly Ala Leu Ser Leu Ser Ser 
            260                 265                 270         


Thr His Ser Tyr Asp Arg Tyr Pro Thr Leu Arg Ser His Arg Ser Ser 
        275                 280                 285             


Pro Tyr Pro Ser Pro Tyr Ala His Arg Asn Asn Ser Pro Thr Tyr Ser 
    290                 295                 300                 


Asp Asn Ser Pro Ala Cys Leu Ser Met Leu Gln Ser His Asp Asn Trp 
305                 310                 315                 320 


Ser Ser Leu Arg Met Pro Ala His Pro Ser Met Leu Pro Val Ser His 
                325                 330                 335     


Asn Ala Ser Pro Pro Thr Ser Ser Ser Gln Tyr Pro Ser Leu Trp Ser 
            340                 345                 350         


Val Ser Asn Gly Ala Val Thr Leu Gly Ser Gln Ala Ala Ala Val Ser 
        355                 360                 365             


Asn Gly Leu Gly Ala Gln Phe Phe Arg Gly Ser Pro Ala His Tyr Thr 
    370                 375                 380                 


Pro Leu Thr His Pro Val Ser Ala Pro Ser Ser Ser Gly Phe Pro Met 
385                 390                 395                 400 


Tyr Lys Gly Ala Ala Ala Ala Thr Asp Ile Val Asp Ser Gln Tyr Asp 
                405                 410                 415     


Ala Ala Ala Gln Gly His Leu Ile Ala Ser Trp Thr Pro Val Ser Pro 
            420                 425                 430         


Pro Ser Met Arg Gly Arg Lys Arg Arg Ser Asp Phe Leu Leu Leu Gln 
        435                 440                 445             


Asn Pro Ala Ser Thr Cys Val Pro Glu Pro Ala Ser Gln His Thr Leu 
    450                 455                 460                 


Arg Ser Gly Pro Gly Cys Leu Gln Gln Pro Glu Gln Gln Gly Val Arg 
465                 470                 475                 480 


Asp Pro Gly Gly Ile Trp Ala Lys Leu Gly Ala Ala Glu Ala Ser Ala 
                485                 490                 495     


Glu Cys Leu Gln Gly Arg Arg Ser Arg Gly Ala Ser Gly Ser Glu Pro 
            500                 505                 510         


His Gln Met Gly Ser Asp Val His Asp Leu Asn Ala Leu Leu Pro Ala 
        515                 520                 525             


Val Pro Ser Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val Ser Gly 
    530                 535                 540                 


Ala Ala Gln Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly Ala Ser 
545                 550                 555                 560 


Ala Tyr Gly Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro Pro Pro 
                565                 570                 575     


Pro Pro Pro Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro Ser Trp 
            580                 585                 590         


Gly Gly Ala Glu Pro His Glu Lys Gln Cys Leu Ser Ala Phe Thr Val 
        595                 600                 605             


His Phe Phe Gly Gln Phe Thr Gly Thr Val Gly Ala Cys Arg Tyr Gly 
    610                 615                 620                 


Pro Phe Gly Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln Ala Arg 
625                 630                 635                 640 


Met Phe Pro Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser Gln Pro 
                645                 650                 655     


Thr Ile Arg Asn Gln Gly Phe Ser Thr Val Thr Phe Asp Gly Met Pro 
            660                 665                 670         


Ser Tyr Gly His Thr Pro Ser His His Ala Ala Gln Phe Pro Asn His 
        675                 680                 685             


Ser Phe Lys His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu Gly Glu 
    690                 695                 700                 


Gln Gln Tyr Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr Pro Thr 
705                 710                 715                 720 


Asp Ser Cys Thr Gly Asn Gln Ala Leu Leu Leu Arg Met Pro Phe Ser 
                725                 730                 735     


Ser Asp Asn Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met Ile Trp 
            740                 745                 750         


Asn Gln Met Asn Leu Gly Ala Thr Leu Lys Gly Val Ala Ala Gly Ser 
        755                 760                 765             


Ser Ser Ser Val Lys Trp Thr Ala Gly Gln Ser Asn His Ser Thr Gly 
    770                 775                 780                 


Tyr Glu Ser Asp Asn His Thr Met Pro Ile Leu Cys Gly Ala Gln Tyr 
785                 790                 795                 800 


Arg Ile His Thr His Gly Val Phe Arg Gly Ile Gln Asp Val Arg Arg 
                805                 810                 815     


Val Pro Gly Val Ala Pro Thr Leu Val Gly Ser Ala Ser Glu Thr Ser 
            820                 825                 830         


Glu Lys His Pro Phe Met Cys Ala Tyr Pro Gly Cys Asn Lys Arg Tyr 
        835                 840                 845             


Phe Lys Leu Ser His Leu Lys Met His Ser Arg Lys His Thr Gly Glu 
    850                 855                 860                 


Lys Leu Tyr Gln Cys Asp Phe Lys Asp Cys Glu Arg Arg Phe Ser Cys 
865                 870                 875                 880 


Ser Asp Gln Leu Lys Arg His Gln Arg Arg His Thr Gly Val Lys Pro 
                885                 890                 895     


Phe Gln Cys Lys Thr Cys Gln Arg Thr Phe Ser Trp Ser Asn His Leu 
            900                 905                 910         


Lys Thr His Thr Arg Thr His Thr Gly Lys Thr Ile Glu Lys Pro Phe 
        915                 920                 925             


Ser Cys Arg Trp Pro Ser Cys Gln Lys Lys Phe Ala Arg Ser Asn Glu 
    930                 935                 940                 


Leu Val His His His Asn Met His Gln Arg Asn Met Thr Lys Leu Gln 
945                 950                 955                 960 


Leu Val Leu Arg Gly Arg Lys Arg Arg Ser Thr Glu Tyr Lys Leu Val 
                965                 970                 975     


Val Val Gly Ala Asp Gly Val Gly Lys Ser Ala Leu Thr Ile Gln Leu 
            980                 985                 990         


Ile Gln Asn His Phe Val Arg Gly  Arg Lys Arg Arg Ser  Thr Glu Tyr 
        995                 1000                 1005             


Lys Leu  Val Val Val Gly Ala  Val Gly Val Gly Lys  Ser Ala Leu 
    1010                 1015                 1020             


Thr Ile  Gln Leu Ile Gln Asn  His Phe Val 
    1025                 1030             


<210>  19
<211>  2256
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
atgtggaatc tgctgcacga gacagatagc gccgtggcta ccgttagaag gcccagatgg       60

ctttgtgctg gcgctctggt tctggctggc ggcttttttc tgctgggctt cctgttcggc      120

tggttcatca agagcagcaa cgaggccacc aacatcaccc ctaagcacaa catgaaggcc      180

tttctggacg agctgaaggc cgagaatatc aagaagttcc tgtacaactt cacgcacatc      240

cctcacctgg ccggcaccga gcagaatttt cagctggcca agcagatcca gagccagtgg      300

aaagagttcg gcctggactc tgtggaactg gcccactacg atgtgctgct gagctacccc      360

aacaagacac accccaacta catcagcatc atcaacgagg acggcaacga gatcttcaac      420

accagcctgt tcgagcctcc acctcctggc tacgagaacg tgtccgatat cgtgcctcca      480

ttcagcgctt tcagcccaca gcggatgcct gagggctacc tggtgtacgt gaactacgcc      540

agaaccgagg acttcttcaa gctggaatgg gacatgaaga tcagctgcag cggcaagatc      600

gtgatcgccc ggtacagaaa ggtgttccgc gagaacaaag tgaagaacgc ccagctggca      660

ggcgccaaag gcgtgatcct gtatagcgac cccgccgact attttgcccc tggcgtgaag      720

tcttaccccg acggctggaa ttttcctggc ggcggagtgc agcggcggaa catccttaat      780

cttaacggcg ctggcgaccc tctgacacct ggctatcctg ccaatgagta cgcctacaga      840

cacggaattg ccgaggctgt gggcctgcct tctattcctg tgcaccctgt gcggtactac      900

gacgcccaga aactgctgga aaagatgggc ggaagcgccc ctcctgactc ttcttggaga      960

ggctctctga aggtgcccta caatgtcggc ccaggcttca ccggcaactt cagcacccag     1020

aaagtgaaaa tgcacatcca cagcaccaac gaagtgaccc ggatctacaa cgtgatcggc     1080

acactgagag gcgccgtgga acccgacaaa tacgtgatcc tcggcggcca cagagacagc     1140

tgggtgttcg gaggaatcga ccctcaatct ggcgccgctg tggtgtatga gatcgtgcgg     1200

tctttcggca ccctgaagaa agaaggatgg cggcccagac ggaccatcct gtttgcctct     1260

tgggacgccg aggaatttgg cctgctggga tctacagagt gggccgaaga gaacagcaga     1320

ctgctgcaag aaagaggcgt ggcctacatc aacgccgaca gcagcatcga gggcaactac     1380

accctgcgga tcgattgcac ccctctgatg tacagcctgg tgcacaacct gaccaaagag     1440

ctgaagtccc ctgacgaggg ctttgagggc aagagcctgt acaagagctg gaccaagaag     1500

tccccatctc ctgagttcag cggcatgccc agaatctcta agctggaaag cggcaacaac     1560

ttcgaggtgt tcttccagcg gctgggaatc gcctctggaa tcgccagata caccaagaac     1620

tgggagacaa acaagttctc cggctatccc ctgtaccaca gcgtgtacga gacatacgag     1680

ctggtggaaa agttctacga ccccatgttc aagtaccacc tgacagtggc ccaagtgcgc     1740

ggaggcatgg tgttcgaact ggccaatagc atcgtgctgc ccttcaactg cagagactac     1800

gccgtggtgc tgcggaagta cgccgacaag atctacagca tcagcatgaa gcacccgcaa     1860

gagatgaaga cctacagcgt gtccttcgac tccctgttct tcgccgtgaa gaacttcacc     1920

aagatcgcca gcaagttcag cgagcggctg caggacttcg acaagagcaa ccctatcgtg     1980

ctgaggatga tgaacgacca gctgatgttc ctggaacggg ccttcatcaa ccctctggga     2040

ctgcccgaca gacccttcta caggcacgtg atctgtgccc ctagcagcca caacaaatac     2100

gccggcgaga gcttccccgg catctacgat gccctgttcg acatcgagag caacgtgaac     2160

cctagcaagg cctggggcga agtgaagaga cagatctacg tggccgcatt cacagtgcag     2220

gccgctgccg aaacactgtc tgaggtggcc tgatga                               2256


<210>  20
<211>  750
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Val Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr His Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Arg Met Pro Glu Gly Tyr Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Trp Asp Met 
            180                 185                 190         


Lys Ile Ser Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Arg Lys Val 
        195                 200                 205             


Phe Arg Glu Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Phe Pro Gly Gly Gly Val Gln Arg Arg 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg His Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Val Arg Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Lys Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val Tyr Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Ile 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Lys Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Glu Ser Gly Asn Asn Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Ile Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asn Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Phe Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Lys Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Asn Pro Ile Val Leu Arg Met Met Asn Asp Gln Leu Met Phe Leu Glu 
            660                 665                 670         


Arg Ala Phe Ile Asn Pro Leu Gly Leu Pro Asp Arg Pro Phe Tyr Arg 
        675                 680                 685             


His Val Ile Cys Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu Ser 
    690                 695                 700                 


Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Asn Val Asn 
705                 710                 715                 720 


Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala Ala 
                725                 730                 735     


Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
            740                 745                 750 


<210>  21
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
accgagtaca agctggtggt tgttggagcc gatggcgtgg gaaagagcgc cctgacaatt       60

cagctgatcc agaaccactt cgtg                                              84


<210>  22
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Asp Gly Val Gly Lys Ser 
1               5                   10                  15      


Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val 
            20                  25              


<210>  23
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
acagagtata agctcgtggt cgtgggcgct gtcggagtgg gaaaatctgc cctgaccatc       60

caactcattc agaatcactt tgtg                                              84


<210>  24
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Thr Glu Tyr Lys Leu Val Val Val Gly Ala Val Gly Val Gly Lys Ser 
1               5                   10                  15      


Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val 
            20                  25              


<210>  25
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
ggcagccctg gcatgggtgt gcatgtgggt gcagcc                                 36


<210>  26
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
tttccaccat tagcacgcgg g                                                 21


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
aatctgatat agctcaatcc g                                                 21


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
gaagcccttc agctgtagat gg                                                22


<210>  29
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  29
ctgaattgtc agggcgctc                                                    19


<210>  30
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  30
catgcaccag aggaacatga cc                                                22


<210>  31
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
gagttggatg gtcagggcag at                                                22


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32

Arg Gly Arg Lys Arg Arg Ser 
1               5           


<210>  33
<211>  567
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg       60

atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga ggattcctac      120

aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt      180

caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg ctttctttgt      240

gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt      300

aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa atgtgatttg      360

ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta tggaattcct      420

tttattgaaa catcagcaaa gacaagacag agagtggagg atgcttttta tacattggtg      480

agagagatcc gacaatacag attgaaaaaa atcagcaaag aagaaaagac tcctggctgt      540

gtgaaaatta aaaaatgcat tataatg                                          567


<210>  34
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  35
<211>  1179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35
atggaggagc cgcagtcaga tcctagcgtc gagccccctc tgagtcagga aacattttca       60

gacctatgga aactacttcc tgaaaacaac gttctgtccc ccttgccgtc ccaagcaatg      120

gatgatttga tgctgtcccc ggacgatatt gaacaatggt tcactgaaga cccaggtcca      180

gatgaagctc ccagaatgcc agaggctgct ccccccgtgg cccctgcacc agcagctcct      240

acaccggcgg cccctgcacc agccccctcc tggcccctgt catcttctgt cccttcccag      300

aaaacctacc agggcagcta cggtttccgt ctgggcttct tgcattctgg gacagccaag      360

tctgtgactt gcacgtactc ccctgccctc aacaagatgt tttgccaact ggccaagacc      420

tgccctgtgc agctgtgggt tgattccaca cccccgcccg gcacccgcgt ccgcgccatg      480

gccatctaca agcagtcaca gcacatgacg gaggttgtga ggcgctgccc ccaccatgag      540

cgctgctcag atagcgatgg tctggcccct cctcagcatc ttatccgagt ggaaggaaat      600

ttgcgtgtgg agtatttgga tgacagaaac acttttcgac atagtgtggt ggtgccctat      660

gagccgcctg aggttggctc tgactgtacc accatccact acaactacat gtgtaacagt      720

tcctgcatgg gcggcatgaa ccggaggccc atcctcacca tcatcacact ggaagactcc      780

agtggtaatc tactgggacg gaacagcttt gaggtgcgtg tttgtgcctg tcctgggaga      840

gaccggcgca cagaggaaga gaatctccgc aagaaagggg agcctcacca cgagctgccc      900

ccagggagca ctaagcgagc actgcccaac aacaccagct cctctcccca gccaaagaag      960

aaaccactgg atggagaata tttcaccctt cagatccgtg ggcgtgagcg cttcgagatg     1020

ttccgagagc tgaatgaggc cttggaactc aaggatgccc aggctgggaa ggagccaggg     1080

gggagcaggg ctcactccag ccacctgaag tccaaaaagg gtcagtctac ctcccgccat     1140

aaaaaactca tgttcaagac agaagggcct gactcagac                            1179


<210>  36
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Met Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro Leu Ser Gln 
1               5                   10                  15      


Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu Ser Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Ser Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Ser Lys Lys Gly Gln Ser Thr Ser Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Ser Asp 
385                 390             


<210>  37
<211>  3204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37
atgcctccac gaccatcatc aggtgaactg tggggcatcc acttgatgcc cccaagaatc       60

ctagtagaat gtttactacc aaatggaatg atagtgactt tagaatgcct ccgtgaggct      120

acattaataa ccataaagca tgaactattt aaagaagcaa gaaaataccc cctccatcaa      180

cttcttcaag atgaatcttc ttacattttc gtaagtgtta ctcaagaagc agaaagggaa      240

gaattttttg atgaaacaag acgactttgt gaccttcggc tttttcaacc ctttttaaaa      300

gtaattgaac cagtaggcaa ccgtgaagaa aagatcctca atcgagaaat tggttttgct      360

atcggcatgc cagtgtgtga atttgatatg gttaaagatc cagaagtaca ggacttccga      420

agaaatattc tgaacgtttg taaagaagct gtggatctta gggacctcaa ttcacctcat      480

agtagagcaa tgtatgtcta tcctccaaat gtagaatctt caccagaatt gccaaagcac      540

atatataata aattagataa agggcaaata atagtggtga tctgggtaat agtttctcca      600

aataatgaca agcagaagta tactctgaaa atcaaccatg actgtgtacc agaacaagta      660

attgctgaag caatcaggaa aaaaactcga agtatgttgc tatcctctga acaactaaaa      720

ctctgtgttt tagaatatca gggcaagtat attttaaaag tgtgtggatg tgatgaatac      780

ttcctagaaa aatatcctct gagtcagtat aagtatataa gaagctgtat aatgcttggg      840

aggatgccca atttgatgtt gatggctaaa gaaagccttt attctcaact gccaatggac      900

tgttttacaa tgccatctta ttccagacgc atttccacag ctacaccata tatgaatgga      960

gaaacatcta caaaatccct ttgggttata aatagtgcac tcagaataaa aattctttgt     1020

gcaacctacg tgaatgtaaa tattcgagac attgataaga tctatgttcg aacaggtatc     1080

taccatggag gagaaccctt atgtgacaat gtgaacactc aaagagtacc ttgttccaat     1140

cccaggtgga atgaatggct gaattatgat atatacattc ctgatcttcc tcgtgctgct     1200

cgactttgcc tttccatttg ctctgttaaa ggccgaaagg gtgctaaaga ggaacactgt     1260

ccattggcat ggggaaatat aaacttgttt gattacacag acactctagt atctggaaaa     1320

atggctttga atctttggcc agtacctcat ggattagaag atttgctgaa ccctattggt     1380

gttactggat caaatccaaa taaagaaact ccatgcttag agttggagtt tgactggttc     1440

agcagtgtgg taaagttccc agatatgtca gtgattgaag agcatgccaa ttggtctgta     1500

tcccgagaag caggatttag ctattcccac gcaggactga gtaacagact agctagagac     1560

aatgaattaa gggaaaatga caaagaacag ctcaaagcaa tttctacacg agatcctctc     1620

tctgaaatca ctgagcagga gaaagatttt ctatggagtc acagacacta ttgtgtaact     1680

atccccgaaa ttctacccaa attgcttctg tctgttaaat ggaattctag agatgaagta     1740

gcccagatgt attgcttggt aaaagattgg cctccaatca aacctgaaca ggctatggaa     1800

cttctggact gtaattaccc agatcctatg gttcgaggtt ttgctgttcg gtgcttggaa     1860

aaatatttaa cagatgacaa actttctcag tatttaattc agctagtaca ggtcctaaaa     1920

tatgaacaat atttggataa cttgcttgtg agatttttac tgaagaaagc attgactaat     1980

caaaggattg ggcacttttt cttttggcat ttaaaatctg agatgcacaa taaaacagtt     2040

agccagaggt ttggcctgct tttggagtcc tattgtcgtg catgtgggat gtatttgaag     2100

cacctgaata ggcaagtcga ggcaatggaa aagctcatta acttaactga cattctcaaa     2160

caggagaaga aggatgaaac acaaaaggta cagatgaagt ttttagttga gcaaatgagg     2220

cgaccagatt tcatggatgc tctacagggc tttctgtctc ctctaaaccc tgctcatcaa     2280

ctaggaaacc tcaggcttga agagtgtcga attatgtcct ctgcaaaaag gccactgtgg     2340

ttgaattggg agaacccaga catcatgtca gagttactgt ttcagaacaa tgagatcatc     2400

tttaaaaatg gggatgattt acggcaagat atgctaacac ttcaaattat tcgtattatg     2460

gaaaatatct ggcaaaatca aggtcttgat cttcgaatgt taccttatgg ttgtctgtca     2520

atcggtgact gtgtgggact tattgaggtg gtgcgaaatt ctcacactat tatgcaaatt     2580

cagtgcaaag gcggcttgaa aggtgcactg cagttcaaca gccacacact acatcagtgg     2640

ctcaaagaca agaacaaagg agaaatatat gatgcagcca ttgacctgtt tacacgttca     2700

tgtgctggat actgtgtagc taccttcatt ttgggaattg gagatcgtca caatagtaac     2760

atcatggtga aagacgatgg acaactgttt catatagatt ttggacactt tttggatcac     2820

aagaagaaaa aatttggtta taaacgagaa cgtgtgccat ttgttttgac acaggatttc     2880

ttaatagtga ttagtaaagg agcccaagaa tgcacaaaga caagagaatt tgagaggttt     2940

caggagatgt gttacaaggc ttatctagct attcgacagc atgccaatct cttcataaat     3000

cttttctcaa tgatgcttgg ctctggaatg ccagaactac aatcttttga tgacattgca     3060

tacattcgaa agaccctagc cttagataaa actgagcaag aggctttgga gtatttcatg     3120

aaacaaatga atgatgcaca tcatggtggc tggacaacaa aaatggattg gatcttccac     3180

acaattaaac agcatgcatt gaac                                            3204


<210>  38
<211>  1068
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Pro Pro Arg Pro Ser Ser Gly Glu Leu Trp Gly Ile His Leu Met 
1               5                   10                  15      


Pro Pro Arg Ile Leu Val Glu Cys Leu Leu Pro Asn Gly Met Ile Val 
            20                  25                  30          


Thr Leu Glu Cys Leu Arg Glu Ala Thr Leu Ile Thr Ile Lys His Glu 
        35                  40                  45              


Leu Phe Lys Glu Ala Arg Lys Tyr Pro Leu His Gln Leu Leu Gln Asp 
    50                  55                  60                  


Glu Ser Ser Tyr Ile Phe Val Ser Val Thr Gln Glu Ala Glu Arg Glu 
65                  70                  75                  80  


Glu Phe Phe Asp Glu Thr Arg Arg Leu Cys Asp Leu Arg Leu Phe Gln 
                85                  90                  95      


Pro Phe Leu Lys Val Ile Glu Pro Val Gly Asn Arg Glu Glu Lys Ile 
            100                 105                 110         


Leu Asn Arg Glu Ile Gly Phe Ala Ile Gly Met Pro Val Cys Glu Phe 
        115                 120                 125             


Asp Met Val Lys Asp Pro Glu Val Gln Asp Phe Arg Arg Asn Ile Leu 
    130                 135                 140                 


Asn Val Cys Lys Glu Ala Val Asp Leu Arg Asp Leu Asn Ser Pro His 
145                 150                 155                 160 


Ser Arg Ala Met Tyr Val Tyr Pro Pro Asn Val Glu Ser Ser Pro Glu 
                165                 170                 175     


Leu Pro Lys His Ile Tyr Asn Lys Leu Asp Lys Gly Gln Ile Ile Val 
            180                 185                 190         


Val Ile Trp Val Ile Val Ser Pro Asn Asn Asp Lys Gln Lys Tyr Thr 
        195                 200                 205             


Leu Lys Ile Asn His Asp Cys Val Pro Glu Gln Val Ile Ala Glu Ala 
    210                 215                 220                 


Ile Arg Lys Lys Thr Arg Ser Met Leu Leu Ser Ser Glu Gln Leu Lys 
225                 230                 235                 240 


Leu Cys Val Leu Glu Tyr Gln Gly Lys Tyr Ile Leu Lys Val Cys Gly 
                245                 250                 255     


Cys Asp Glu Tyr Phe Leu Glu Lys Tyr Pro Leu Ser Gln Tyr Lys Tyr 
            260                 265                 270         


Ile Arg Ser Cys Ile Met Leu Gly Arg Met Pro Asn Leu Met Leu Met 
        275                 280                 285             


Ala Lys Glu Ser Leu Tyr Ser Gln Leu Pro Met Asp Cys Phe Thr Met 
    290                 295                 300                 


Pro Ser Tyr Ser Arg Arg Ile Ser Thr Ala Thr Pro Tyr Met Asn Gly 
305                 310                 315                 320 


Glu Thr Ser Thr Lys Ser Leu Trp Val Ile Asn Ser Ala Leu Arg Ile 
                325                 330                 335     


Lys Ile Leu Cys Ala Thr Tyr Val Asn Val Asn Ile Arg Asp Ile Asp 
            340                 345                 350         


Lys Ile Tyr Val Arg Thr Gly Ile Tyr His Gly Gly Glu Pro Leu Cys 
        355                 360                 365             


Asp Asn Val Asn Thr Gln Arg Val Pro Cys Ser Asn Pro Arg Trp Asn 
    370                 375                 380                 


Glu Trp Leu Asn Tyr Asp Ile Tyr Ile Pro Asp Leu Pro Arg Ala Ala 
385                 390                 395                 400 


Arg Leu Cys Leu Ser Ile Cys Ser Val Lys Gly Arg Lys Gly Ala Lys 
                405                 410                 415     


Glu Glu His Cys Pro Leu Ala Trp Gly Asn Ile Asn Leu Phe Asp Tyr 
            420                 425                 430         


Thr Asp Thr Leu Val Ser Gly Lys Met Ala Leu Asn Leu Trp Pro Val 
        435                 440                 445             


Pro His Gly Leu Glu Asp Leu Leu Asn Pro Ile Gly Val Thr Gly Ser 
    450                 455                 460                 


Asn Pro Asn Lys Glu Thr Pro Cys Leu Glu Leu Glu Phe Asp Trp Phe 
465                 470                 475                 480 


Ser Ser Val Val Lys Phe Pro Asp Met Ser Val Ile Glu Glu His Ala 
                485                 490                 495     


Asn Trp Ser Val Ser Arg Glu Ala Gly Phe Ser Tyr Ser His Ala Gly 
            500                 505                 510         


Leu Ser Asn Arg Leu Ala Arg Asp Asn Glu Leu Arg Glu Asn Asp Lys 
        515                 520                 525             


Glu Gln Leu Lys Ala Ile Ser Thr Arg Asp Pro Leu Ser Glu Ile Thr 
    530                 535                 540                 


Glu Gln Glu Lys Asp Phe Leu Trp Ser His Arg His Tyr Cys Val Thr 
545                 550                 555                 560 


Ile Pro Glu Ile Leu Pro Lys Leu Leu Leu Ser Val Lys Trp Asn Ser 
                565                 570                 575     


Arg Asp Glu Val Ala Gln Met Tyr Cys Leu Val Lys Asp Trp Pro Pro 
            580                 585                 590         


Ile Lys Pro Glu Gln Ala Met Glu Leu Leu Asp Cys Asn Tyr Pro Asp 
        595                 600                 605             


Pro Met Val Arg Gly Phe Ala Val Arg Cys Leu Glu Lys Tyr Leu Thr 
    610                 615                 620                 


Asp Asp Lys Leu Ser Gln Tyr Leu Ile Gln Leu Val Gln Val Leu Lys 
625                 630                 635                 640 


Tyr Glu Gln Tyr Leu Asp Asn Leu Leu Val Arg Phe Leu Leu Lys Lys 
                645                 650                 655     


Ala Leu Thr Asn Gln Arg Ile Gly His Phe Phe Phe Trp His Leu Lys 
            660                 665                 670         


Ser Glu Met His Asn Lys Thr Val Ser Gln Arg Phe Gly Leu Leu Leu 
        675                 680                 685             


Glu Ser Tyr Cys Arg Ala Cys Gly Met Tyr Leu Lys His Leu Asn Arg 
    690                 695                 700                 


Gln Val Glu Ala Met Glu Lys Leu Ile Asn Leu Thr Asp Ile Leu Lys 
705                 710                 715                 720 


Gln Glu Lys Lys Asp Glu Thr Gln Lys Val Gln Met Lys Phe Leu Val 
                725                 730                 735     


Glu Gln Met Arg Arg Pro Asp Phe Met Asp Ala Leu Gln Gly Phe Leu 
            740                 745                 750         


Ser Pro Leu Asn Pro Ala His Gln Leu Gly Asn Leu Arg Leu Glu Glu 
        755                 760                 765             


Cys Arg Ile Met Ser Ser Ala Lys Arg Pro Leu Trp Leu Asn Trp Glu 
    770                 775                 780                 


Asn Pro Asp Ile Met Ser Glu Leu Leu Phe Gln Asn Asn Glu Ile Ile 
785                 790                 795                 800 


Phe Lys Asn Gly Asp Asp Leu Arg Gln Asp Met Leu Thr Leu Gln Ile 
                805                 810                 815     


Ile Arg Ile Met Glu Asn Ile Trp Gln Asn Gln Gly Leu Asp Leu Arg 
            820                 825                 830         


Met Leu Pro Tyr Gly Cys Leu Ser Ile Gly Asp Cys Val Gly Leu Ile 
        835                 840                 845             


Glu Val Val Arg Asn Ser His Thr Ile Met Gln Ile Gln Cys Lys Gly 
    850                 855                 860                 


Gly Leu Lys Gly Ala Leu Gln Phe Asn Ser His Thr Leu His Gln Trp 
865                 870                 875                 880 


Leu Lys Asp Lys Asn Lys Gly Glu Ile Tyr Asp Ala Ala Ile Asp Leu 
                885                 890                 895     


Phe Thr Arg Ser Cys Ala Gly Tyr Cys Val Ala Thr Phe Ile Leu Gly 
            900                 905                 910         


Ile Gly Asp Arg His Asn Ser Asn Ile Met Val Lys Asp Asp Gly Gln 
        915                 920                 925             


Leu Phe His Ile Asp Phe Gly His Phe Leu Asp His Lys Lys Lys Lys 
    930                 935                 940                 


Phe Gly Tyr Lys Arg Glu Arg Val Pro Phe Val Leu Thr Gln Asp Phe 
945                 950                 955                 960 


Leu Ile Val Ile Ser Lys Gly Ala Gln Glu Cys Thr Lys Thr Arg Glu 
                965                 970                 975     


Phe Glu Arg Phe Gln Glu Met Cys Tyr Lys Ala Tyr Leu Ala Ile Arg 
            980                 985                 990         


Gln His Ala Asn Leu Phe Ile Asn  Leu Phe Ser Met Met  Leu Gly Ser 
        995                 1000                 1005             


Gly Met  Pro Glu Leu Gln Ser  Phe Asp Asp Ile Ala  Tyr Ile Arg 
    1010                 1015                 1020             


Lys Thr  Leu Ala Leu Asp Lys  Thr Glu Gln Glu Ala  Leu Glu Tyr 
    1025                 1030                 1035             


Phe Met  Lys Gln Met Asn Asp  Ala His His Gly Gly  Trp Thr Thr 
    1040                 1045                 1050             


Lys Met  Asp Trp Ile Phe His  Thr Ile Lys Gln His  Ala Leu Asn 
    1055                 1060                 1065             


<210>  39
<211>  2124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39
atgaatcagg aactgctctc tgtgggcagc aaaagacgac gaactggagg ctctctgaga       60

ggtaaccctt cctcaagcca ggtagatgaa gaacagatga atcgtgtggt agaggaggaa      120

cagcaacagc aactcagaca acaagaggag gagcacactg caaggaatgg tgaagttgtt      180

ggagtagaac ctagacctgg aggccaaaat gattcccagc aaggacagtt ggaagaaaac      240

aataatagat ttatttcggt agatgaggac tcctcaggaa accaagaaga acaagaggaa      300

gatgaagaac atgctggtga acaagatgag gaggatgagg aggaggagga gatggaccag      360

gagagtgacg attttgatca gtctgatgat agtagcagag aagatgaaca tacacatact      420

aacagtgtca cgaactccag tagtattgtg gacctgcccg ttcaccaact ctcctcccca      480

ttctatacaa aaacaacaaa aatgaaaaga aagttggacc atggttctga ggtccgctct      540

ttttctttgg gaaagaaacc atgcaaagtc tcagaatata caagtaccac tgggcttgta      600

ccatgttcag caacaccaac aacttttggg gacctcagag cagccaatgg ccaagggcaa      660

caacgacgcc gaattacatc tgtccagcca cctacaggcc tccaggaatg gctaaaaatg      720

tttcagagct ggagtggacc agagaaattg cttgctttag atgaactcat tgatagttgt      780

gaaccaacac aagtaaaaca tatgatgcaa gtgatagaac cccagtttca acgagacttc      840

atttcattgc tccctaaaga gttggcactc tatgtgcttt cattcctgga acccaaagac      900

ctgctacaag cagctcagac atgtcgctac tggagaattt tggctgaaga caaccttctc      960

tggagagaga aatgcaaaga agaggggatt gatgaaccat tgcacatcaa gagaagaaaa     1020

gtaataaaac caggtttcat acacagtcca tggaaaagtg catacatcag acagcacaga     1080

attgatacta actggaggcg aggagaactc aaatctccta aggtgctgaa aggacatgat     1140

gatcatgtga tcacatgctt acagttttgt ggtaaccgaa tagttagtgg ttctgatgac     1200

aacactttaa aagtttggtc agcagtcaca ggcaaatgtc tgagaacatt agtgggacat     1260

acaggtggag tatggtcatc acaaatgaga gacaacatca tcattagtgg atctacagat     1320

cggacactca aagtgtggaa tgcagagact ggagaatgta tacacacctt atatgggcat     1380

acttccactg tgcgttgtat gcatcttcat gaaaaaagag ttgttagcgg ttctcgagat     1440

gccactctta gggtttggga tattgagaca ggccagtgtt tacatgtttt gatgggtcat     1500

gttgcagcag tccgctgtgt tcaatatgat ggcaggaggg ttgttagtgg agcatatgat     1560

tttatggtaa aggtgtggga tccagagact gaaacctgtc tacacacgtt gcaggggcat     1620

actaatagag tctattcatt acagtttgat ggtatccatg tggtgagtgg atctcttgat     1680

acatcaatcc gtgtttggga tgtggagaca gggaattgca ttcacacgtt aacagggcac     1740

cagtcgttaa caagtggaat ggaactcaaa gacaatattc ttgtctctgg gaatgcagat     1800

tctacagtta aaatctggga tatcaaaaca ggacagtgtt tacaaacatt gcaaggtccc     1860

aacaagcatc agagtgctgt gacctgttta cagttcaaca agaactttgt aattaccagc     1920

tcagatgatg gaactgtaaa actatgggac ttgaaaacgg gtgaatttat tcgaaaccta     1980

gtcacattgg agagtggggg gagtggggga gttgtgtggc ggatcagagc ctcaaacaca     2040

aagctggtgt gtgcagttgg gagtcggaat gggactgaag aaaccaagct gctggtgctg     2100

gactttgatg tggacatgaa gtga                                            2124


<210>  40
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Asn Gln Glu Leu Leu Ser Val Gly Ser Lys Arg Arg Arg Thr Gly 
1               5                   10                  15      


Gly Ser Leu Arg Gly Asn Pro Ser Ser Ser Gln Val Asp Glu Glu Gln 
            20                  25                  30          


Met Asn Arg Val Val Glu Glu Glu Gln Gln Gln Gln Leu Arg Gln Gln 
        35                  40                  45              


Glu Glu Glu His Thr Ala Arg Asn Gly Glu Val Val Gly Val Glu Pro 
    50                  55                  60                  


Arg Pro Gly Gly Gln Asn Asp Ser Gln Gln Gly Gln Leu Glu Glu Asn 
65                  70                  75                  80  


Asn Asn Arg Phe Ile Ser Val Asp Glu Asp Ser Ser Gly Asn Gln Glu 
                85                  90                  95      


Glu Gln Glu Glu Asp Glu Glu His Ala Gly Glu Gln Asp Glu Glu Asp 
            100                 105                 110         


Glu Glu Glu Glu Glu Met Asp Gln Glu Ser Asp Asp Phe Asp Gln Ser 
        115                 120                 125             


Asp Asp Ser Ser Arg Glu Asp Glu His Thr His Thr Asn Ser Val Thr 
    130                 135                 140                 


Asn Ser Ser Ser Ile Val Asp Leu Pro Val His Gln Leu Ser Ser Pro 
145                 150                 155                 160 


Phe Tyr Thr Lys Thr Thr Lys Met Lys Arg Lys Leu Asp His Gly Ser 
                165                 170                 175     


Glu Val Arg Ser Phe Ser Leu Gly Lys Lys Pro Cys Lys Val Ser Glu 
            180                 185                 190         


Tyr Thr Ser Thr Thr Gly Leu Val Pro Cys Ser Ala Thr Pro Thr Thr 
        195                 200                 205             


Phe Gly Asp Leu Arg Ala Ala Asn Gly Gln Gly Gln Gln Arg Arg Arg 
    210                 215                 220                 


Ile Thr Ser Val Gln Pro Pro Thr Gly Leu Gln Glu Trp Leu Lys Met 
225                 230                 235                 240 


Phe Gln Ser Trp Ser Gly Pro Glu Lys Leu Leu Ala Leu Asp Glu Leu 
                245                 250                 255     


Ile Asp Ser Cys Glu Pro Thr Gln Val Lys His Met Met Gln Val Ile 
            260                 265                 270         


Glu Pro Gln Phe Gln Arg Asp Phe Ile Ser Leu Leu Pro Lys Glu Leu 
        275                 280                 285             


Ala Leu Tyr Val Leu Ser Phe Leu Glu Pro Lys Asp Leu Leu Gln Ala 
    290                 295                 300                 


Ala Gln Thr Cys Arg Tyr Trp Arg Ile Leu Ala Glu Asp Asn Leu Leu 
305                 310                 315                 320 


Trp Arg Glu Lys Cys Lys Glu Glu Gly Ile Asp Glu Pro Leu His Ile 
                325                 330                 335     


Lys Arg Arg Lys Val Ile Lys Pro Gly Phe Ile His Ser Pro Trp Lys 
            340                 345                 350         


Ser Ala Tyr Ile Arg Gln His Arg Ile Asp Thr Asn Trp Arg Arg Gly 
        355                 360                 365             


Glu Leu Lys Ser Pro Lys Val Leu Lys Gly His Asp Asp His Val Ile 
    370                 375                 380                 


Thr Cys Leu Gln Phe Cys Gly Asn Arg Ile Val Ser Gly Ser Asp Asp 
385                 390                 395                 400 


Asn Thr Leu Lys Val Trp Ser Ala Val Thr Gly Lys Cys Leu Arg Thr 
                405                 410                 415     


Leu Val Gly His Thr Gly Gly Val Trp Ser Ser Gln Met Arg Asp Asn 
            420                 425                 430         


Ile Ile Ile Ser Gly Ser Thr Asp Arg Thr Leu Lys Val Trp Asn Ala 
        435                 440                 445             


Glu Thr Gly Glu Cys Ile His Thr Leu Tyr Gly His Thr Ser Thr Val 
    450                 455                 460                 


Arg Cys Met His Leu His Glu Lys Arg Val Val Ser Gly Ser Arg Asp 
465                 470                 475                 480 


Ala Thr Leu Arg Val Trp Asp Ile Glu Thr Gly Gln Cys Leu His Val 
                485                 490                 495     


Leu Met Gly His Val Ala Ala Val Arg Cys Val Gln Tyr Asp Gly Arg 
            500                 505                 510         


Arg Val Val Ser Gly Ala Tyr Asp Phe Met Val Lys Val Trp Asp Pro 
        515                 520                 525             


Glu Thr Glu Thr Cys Leu His Thr Leu Gln Gly His Thr Asn Arg Val 
    530                 535                 540                 


Tyr Ser Leu Gln Phe Asp Gly Ile His Val Val Ser Gly Ser Leu Asp 
545                 550                 555                 560 


Thr Ser Ile Arg Val Trp Asp Val Glu Thr Gly Asn Cys Ile His Thr 
                565                 570                 575     


Leu Thr Gly His Gln Ser Leu Thr Ser Gly Met Glu Leu Lys Asp Asn 
            580                 585                 590         


Ile Leu Val Ser Gly Asn Ala Asp Ser Thr Val Lys Ile Trp Asp Ile 
        595                 600                 605             


Lys Thr Gly Gln Cys Leu Gln Thr Leu Gln Gly Pro Asn Lys His Gln 
    610                 615                 620                 


Ser Ala Val Thr Cys Leu Gln Phe Asn Lys Asn Phe Val Ile Thr Ser 
625                 630                 635                 640 


Ser Asp Asp Gly Thr Val Lys Leu Trp Asp Leu Lys Thr Gly Glu Phe 
                645                 650                 655     


Ile Arg Asn Leu Val Thr Leu Glu Ser Gly Gly Ser Gly Gly Val Val 
            660                 665                 670         


Trp Arg Ile Arg Ala Ser Asn Thr Lys Leu Val Cys Ala Val Gly Ser 
        675                 680                 685             


Arg Asn Gly Thr Glu Glu Thr Lys Leu Leu Val Leu Asp Phe Asp Val 
    690                 695                 700                 


Asp Met Lys 
705         


<210>  41
<211>  1659
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41
atggacaata tgtctattac gaatacacca acaagtaatg atgcctgtct gagcattgtg       60

catagtttga tgtgccatag acaaggtgga gagagtgaaa catttgcaaa aagagcaatt      120

gaaagtttgg taaagaagct gaaggagaaa aaagatgaat tggattcttt aataacagct      180

ataactacaa atggagctca tcctagtaaa tgtgttacca tacagagaac attggatggg      240

aggcttcagg tggctggtcg gaaaggattt cctcatgtga tctatgcccg tctctggagg      300

tggcctgatc ttcacaaaaa tgaactaaaa catgttaaat attgtcagta tgcgtttgac      360

ttaaaatgtg atagtgtctg tgtgaatcca tatcactacg aacgagttgt atcacctgga      420

attgatctct caggattaac actgcagagt aatgctccat caagtatgat ggtgaaggat      480

gaatatgtgc atgactttga gggacagcca tcgttgtcca ctgaaggaca ttcaattcaa      540

accatccagc atccaccaag taatcgtgca tcgacagaga catacagcac cccagctctg      600

ttagccccat ctgagtctaa tgctaccagc actgccaact ttcccaacat tcctgtggct      660

tccacaagtc agcctgccag tatactgggg ggcagccata gtgaaggact gttgcagata      720

gcatcagggc ctcagccagg acagcagcag aatggattta ctggtcagcc agctacttac      780

catcataaca gcactaccac ctggactgga agtaggactg caccatacac acctaatttg      840

cctcaccacc aaaacggcca tcttcagcac cacccgccta tgccgcccca tcccggacat      900

tactggcctg ttcacaatga gcttgcattc cagcctccca tttccaatca tcctgctcct      960

gagtattggt gttccattgc ttactttgaa atggatgttc aggtaggaga gacatttaag     1020

gttccttcaa gctgccctat tgttactgtt gatggatacg tggacccttc tggaggagat     1080

cgcttttgtt tgggtcaact ctccaatgtc cacaggacag aagccattga gagagcaagg     1140

ttgcacatag gcaaaggtgt gcagttggaa tgtaaaggtg aaggtgatgt ttgggtcagg     1200

tgccttagtg accacgcggt ctttgtacag agttactact tagacagaga agctgggcgt     1260

gcacctggag atgctgttca taagatctac ccaagtgcat atataaaggt ctttgatttg     1320

cgtcagtgtc atcgacagat gcagcagcag gcggctactg cacaagctgc agcagctgcc     1380

caggcagcag ccgtggcagg aaacatccct ggcccaggat cagtaggtgg aatagctcca     1440

gctatcagtc tgtcagctgc tgctggaatt ggtgttgatg accttcgtcg cttatgcata     1500

ctcaggatga gttttgtgaa aggctgggga ccggattacc caagacagag catcaaagaa     1560

acaccttgct ggattgaaat tcacttacac cgggccctcc agctcctaga cgaagtactt     1620

cataccatgc cgattgcaga cccacaacct ttagactga                            1659


<210>  42
<211>  552
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Met Asp Asn Met Ser Ile Thr Asn Thr Pro Thr Ser Asn Asp Ala Cys 
1               5                   10                  15      


Leu Ser Ile Val His Ser Leu Met Cys His Arg Gln Gly Gly Glu Ser 
            20                  25                  30          


Glu Thr Phe Ala Lys Arg Ala Ile Glu Ser Leu Val Lys Lys Leu Lys 
        35                  40                  45              


Glu Lys Lys Asp Glu Leu Asp Ser Leu Ile Thr Ala Ile Thr Thr Asn 
    50                  55                  60                  


Gly Ala His Pro Ser Lys Cys Val Thr Ile Gln Arg Thr Leu Asp Gly 
65                  70                  75                  80  


Arg Leu Gln Val Ala Gly Arg Lys Gly Phe Pro His Val Ile Tyr Ala 
                85                  90                  95      


Arg Leu Trp Arg Trp Pro Asp Leu His Lys Asn Glu Leu Lys His Val 
            100                 105                 110         


Lys Tyr Cys Gln Tyr Ala Phe Asp Leu Lys Cys Asp Ser Val Cys Val 
        115                 120                 125             


Asn Pro Tyr His Tyr Glu Arg Val Val Ser Pro Gly Ile Asp Leu Ser 
    130                 135                 140                 


Gly Leu Thr Leu Gln Ser Asn Ala Pro Ser Ser Met Met Val Lys Asp 
145                 150                 155                 160 


Glu Tyr Val His Asp Phe Glu Gly Gln Pro Ser Leu Ser Thr Glu Gly 
                165                 170                 175     


His Ser Ile Gln Thr Ile Gln His Pro Pro Ser Asn Arg Ala Ser Thr 
            180                 185                 190         


Glu Thr Tyr Ser Thr Pro Ala Leu Leu Ala Pro Ser Glu Ser Asn Ala 
        195                 200                 205             


Thr Ser Thr Ala Asn Phe Pro Asn Ile Pro Val Ala Ser Thr Ser Gln 
    210                 215                 220                 


Pro Ala Ser Ile Leu Gly Gly Ser His Ser Glu Gly Leu Leu Gln Ile 
225                 230                 235                 240 


Ala Ser Gly Pro Gln Pro Gly Gln Gln Gln Asn Gly Phe Thr Gly Gln 
                245                 250                 255     


Pro Ala Thr Tyr His His Asn Ser Thr Thr Thr Trp Thr Gly Ser Arg 
            260                 265                 270         


Thr Ala Pro Tyr Thr Pro Asn Leu Pro His His Gln Asn Gly His Leu 
        275                 280                 285             


Gln His His Pro Pro Met Pro Pro His Pro Gly His Tyr Trp Pro Val 
    290                 295                 300                 


His Asn Glu Leu Ala Phe Gln Pro Pro Ile Ser Asn His Pro Ala Pro 
305                 310                 315                 320 


Glu Tyr Trp Cys Ser Ile Ala Tyr Phe Glu Met Asp Val Gln Val Gly 
                325                 330                 335     


Glu Thr Phe Lys Val Pro Ser Ser Cys Pro Ile Val Thr Val Asp Gly 
            340                 345                 350         


Tyr Val Asp Pro Ser Gly Gly Asp Arg Phe Cys Leu Gly Gln Leu Ser 
        355                 360                 365             


Asn Val His Arg Thr Glu Ala Ile Glu Arg Ala Arg Leu His Ile Gly 
    370                 375                 380                 


Lys Gly Val Gln Leu Glu Cys Lys Gly Glu Gly Asp Val Trp Val Arg 
385                 390                 395                 400 


Cys Leu Ser Asp His Ala Val Phe Val Gln Ser Tyr Tyr Leu Asp Arg 
                405                 410                 415     


Glu Ala Gly Arg Ala Pro Gly Asp Ala Val His Lys Ile Tyr Pro Ser 
            420                 425                 430         


Ala Tyr Ile Lys Val Phe Asp Leu Arg Gln Cys His Arg Gln Met Gln 
        435                 440                 445             


Gln Gln Ala Ala Thr Ala Gln Ala Ala Ala Ala Ala Gln Ala Ala Ala 
    450                 455                 460                 


Val Ala Gly Asn Ile Pro Gly Pro Gly Ser Val Gly Gly Ile Ala Pro 
465                 470                 475                 480 


Ala Ile Ser Leu Ser Ala Ala Ala Gly Ile Gly Val Asp Asp Leu Arg 
                485                 490                 495     


Arg Leu Cys Ile Leu Arg Met Ser Phe Val Lys Gly Trp Gly Pro Asp 
            500                 505                 510         


Tyr Pro Arg Gln Ser Ile Lys Glu Thr Pro Cys Trp Ile Glu Ile His 
        515                 520                 525             


Leu His Arg Ala Leu Gln Leu Leu Asp Glu Val Leu His Thr Met Pro 
    530                 535                 540                 


Ile Ala Asp Pro Gln Pro Leu Asp 
545                 550         


<210>  43
<211>  9171
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43
atgagtctag tacttaatga tctgcttatc tgctgccgtc aactagaaca tgatagagct       60

acagaacgaa agaaagaagt tgagaaattt aagcgcctga ttcgagatcc tgaaacaatt      120

aaacatctag atcggcattc agattccaaa caaggaaaat atttgaattg ggatgctgtt      180

tttagatttt tacagaaata tattcagaaa gaaacagaat gtctgagaat agcaaaacca      240

aatgtatcag cctcaacaca agcctccagg cagaaaaaga tgcaggaaat cagtagtttg      300

gtcaaatact tcatcaaatg tgcaaacaga agagcaccta ggctaaaatg tcaagaactc      360

ttaaattata tcatggatac agtgaaagat tcatctaatg gtgctattta cggagctgat      420

tgtagcaaca tactactcaa agacattctt tctgtgagaa aatactggtg tgaaatatct      480

cagcaacagt ggttagaatt gttctctgtg tacttcaggc tctatctgaa accttcacaa      540

gatgttcata gagttttagt ggctagaata attcatgctg ttaccaaagg atgctgttct      600

cagactgacg gattaaattc caaatttttg gacttttttt ccaaggctat tcagtgtgcg      660

agacaagaaa agagctcttc aggtctaaat catatcttag cagctcttac tatcttcctc      720

aagactttgg ctgtcaactt tcgaattcga gtgtgtgaat taggagatga aattcttccc      780

actttgcttt atatttggac tcaacatagg cttaatgatt ctttaaaaga agtcattatt      840

gaattatttc aactgcaaat ttatatccat catccgaaag gagccaaaac ccaagaaaaa      900

ggtgcttatg aatcaacaaa atggagaagt attttataca acttatatga tctgctagtg      960

aatgagataa gtcatatagg aagtagagga aagtattctt caggatttcg taatattgcc     1020

gtcaaagaaa atttgattga attgatggca gatatctgtc accaggtttt taatgaagat     1080

accagatcct tggagatttc tcaatcttac actactacac aaagagaatc tagtgattac     1140

agtgtccctt gcaaaaggaa gaaaatagaa ctaggctggg aagtaataaa agatcacctt     1200

cagaagtcac agaatgattt tgatcttgtg ccttggctac agattgcaac ccaattaata     1260

tcaaagtatc ctgcaagttt acctaactgt gagctgtctc cattactgat gatactatct     1320

cagcttctac cccaacagcg acatggggaa cgtacaccat atgtgttacg atgccttacg     1380

gaagttgcat tgtgtcaaga caagaggtca aacctagaaa gctcacaaaa gtcagattta     1440

ttaaaactct ggaataaaat ttggtgtatt acctttcgtg gtataagttc tgagcaaata     1500

caagctgaaa actttggctt acttggagcc ataattcagg gtagtttagt tgaggttgac     1560

agagaattct ggaagttatt tactgggtca gcctgcagac cttcatgtcc tgcagtatgc     1620

tgtttgactt tggcactgac caccagtata gttccaggaa cggtaaaaat gggaatagag     1680

caaaatatgt gtgaagtaaa tagaagcttt tctttaaagg aatcaataat gaaatggctc     1740

ttattctatc agttagaggg tgacttagaa aatagcacag aagtgcctcc aattcttcac     1800

agtaattttc ctcatcttgt actggagaaa attcttgtga gtctcactat gaaaaactgt     1860

aaagctgcaa tgaatttttt ccaaagcgtg ccagaatgtg aacaccacca aaaagataaa     1920

gaagaacttt cattctcaga agtagaagaa ctatttcttc agacaacttt tgacaagatg     1980

gactttttaa ccattgtgag agaatgtggt atagaaaagc accagtccag tattggcttc     2040

tctgtccacc agaatctcaa ggaatcactg gatcgctgtc ttctgggatt atcagaacag     2100

cttctgaata attactcatc tgagattaca aattcagaaa ctcttgtccg gtgttcacgt     2160

cttttggtgg gtgtccttgg ctgctactgt tacatgggtg taatagctga agaggaagca     2220

tataagtcag aattattcca gaaagccaag tctctaatgc aatgtgcagg agaaagtatc     2280

actctgttta aaaataagac aaatgaggaa ttcagaattg gttccttgag aaatatgatg     2340

cagctatgta cacgttgctt gagcaactgt accaagaaga gtccaaataa gattgcatct     2400

ggctttttcc tgcgattgtt aacatcaaag ctaatgaatg acattgcaga tatttgtaaa     2460

agtttagcat ccttcatcaa aaagccattt gaccgtggag aagtagaatc aatggaagat     2520

gatactaatg gaaatctaat ggaggtggag gatcagtcat ccatgaatct atttaacgat     2580

taccctgata gtagtgttag tgatgcaaac gaacctggag agagccaaag taccataggt     2640

gccattaatc ctttagctga agaatatctg tcaaagcaag atctactttt cttagacatg     2700

ctcaagttct tgtgtttgtg tgtaactact gctcagacca atactgtgtc ctttagggca     2760

gctgatattc ggaggaaatt gttaatgtta attgattcta gcacgctaga acctaccaaa     2820

tccctccacc tgcatatgta tctaatgctt ttaaaggagc ttcctggaga agagtacccc     2880

ttgccaatgg aagatgttct tgaacttctg aaaccactat ccaatgtgtg ttctttgtat     2940

cgtcgtgacc aagatgtttg taaaactatt ttaaaccatg tccttcatgt agtgaaaaac     3000

ctaggtcaaa gcaatatgga ctctgagaac acaagggatg ctcaaggaca gtttcttaca     3060

gtaattggag cattttggca tctaacaaag gagaggaaat atatattctc tgtaagaatg     3120

gccctagtaa attgccttaa aactttgctt gaggctgatc cttattcaaa atgggccatt     3180

cttaatgtaa tgggaaaaga ctttcctgta aatgaagtat ttacacaatt tcttgctgac     3240

aatcatcacc aagttcgcat gttggctgca gagtcaatca atagattgtt ccaggacacg     3300

aagggagatt cttccaggtt actgaaagca cttcctttga agcttcagca aacagctttt     3360

gaaaatgcat acttgaaagc tcaggaagga atgagagaaa tgtcccatag tgctgagaac     3420

cctgaaactt tggatgaaat ttataataga aaatctgttt tactgacgtt gatagctgtg     3480

gttttatcct gtagccctat ctgcgaaaaa caggctttgt ttgccctgtg taaatctgtg     3540

aaagagaatg gattagaacc tcaccttgtg aaaaaggttt tagagaaagt ttctgaaact     3600

tttggatata gacgtttaga agactttatg gcatctcatt tagattatct ggttttggaa     3660

tggctaaatc ttcaagatac tgaatacaac ttatcttctt ttccttttat tttattaaac     3720

tacacaaata ttgaggattt ctatagatct tgttataagg ttttgattcc acatctggtg     3780

attagaagtc attttgatga ggtgaagtcc attgctaatc agattcaaga ggactggaaa     3840

agtcttctaa cagactgctt tccaaagatt cttgtaaata ttcttcctta ttttgcctat     3900

gagggtacca gagacagtgg gatggcacag caaagagaga ctgctaccaa ggtctatgat     3960

atgcttaaaa gtgaaaactt attgggaaaa cagattgatc acttattcat tagtaattta     4020

ccagagattg tggtggagtt attgatgacg ttacatgagc cagcaaattc tagtgccagt     4080

cagagcactg acctctgtga cttttcaggg gatttggatc ctgctcctaa tccacctcat     4140

tttccatcgc atgtgattaa agcaacattt gcctatatca gcaattgtca taaaaccaag     4200

ttaaaaagca ttttagaaat tctttccaaa agccctgatt cctatcagaa aattcttctt     4260

gccatatgtg agcaagcagc tgaaacaaat aatgtttata agaagcacag aattcttaaa     4320

atatatcacc tgtttgttag tttattactg aaagatataa aaagtggctt aggaggagct     4380

tgggcctttg ttcttcgaga cgttatttat actttgattc actatatcaa ccaaaggcct     4440

tcttgtatca tggatgtgtc attacgtagc ttctcccttt gttgtgactt attaagtcag     4500

gtttgccaga cagccgtgac ttactgtaag gatgctctag aaaaccatct tcatgttatt     4560

gttggtacac ttatacccct tgtgtatgag caggtggagg ttcagaaaca ggtattggac     4620

ttgttgaaat acttagtgat agataacaag gataatgaaa acctctatat cacgattaag     4680

cttttagatc cttttcctga ccatgttgtt tttaaggatt tgcgtattac tcagcaaaaa     4740

atcaaataca gtagaggacc cttttcactc ttggaggaaa ttaaccattt tctctcagta     4800

agtgtttatg atgcacttcc attgacaaga cttgaaggac taaaggatct tcgaagacaa     4860

ctggaactac ataaagatca gatggtggac attatgagag cttctcagga taatccgcaa     4920

gatgggatta tggtgaaact agttgtcaat ttgttgcagt tatccaagat ggcaataaac     4980

cacactggtg aaaaagaagt tctagaggct gttggaagct gcttgggaga agtgggtcct     5040

atagatttct ctaccatagc tatacaacat agtaaagatg catcttatac caaggccctt     5100

aagttatttg aagataaaga acttcagtgg accttcataa tgctgaccta cctgaataac     5160

acactggtag aagattgtgt caaagttcga tcagcagctg ttacctgttt gaaaaacatt     5220

ttagccacaa agactggaca tagtttctgg gagatttata agatgacaac agatccaatg     5280

ctggcctatc tacagccttt tagaacatca agaaaaaagt ttttagaagt acccagattt     5340

gacaaagaaa acccttttga aggcctggat gatataaatc tgtggattcc tctaagtgaa     5400

aatcatgaca tttggataaa gacactgact tgtgcttttt tggacagtgg aggcacaaaa     5460

tgtgaaattc ttcaattatt aaagccaatg tgtgaagtga aaactgactt ttgtcagact     5520

gtacttccat acttgattca tgatatttta ctccaagata caaatgaatc atggagaaat     5580

ctgctttcta cacatgttca gggatttttc accagctgtc ttcgacactt ctcgcaaacg     5640

agccgatcca caacccctgc aaacttggat tcagagtcag agcacttttt ccgatgctgt     5700

ttggataaaa aatcacaaag aacaatgctt gctgttgtgg actacatgag aagacaaaag     5760

agaccttctt caggaacaat ttttaatgat gctttctggc tggatttaaa ttatctagaa     5820

gttgccaagg tagctcagtc ttgtgctgct cactttacag ctttactcta tgcagaaatc     5880

tatgcagata agaaaagtat ggatgatcaa gagaaaagaa gtcttgcatt tgaagaagga     5940

agccagagta caactatttc tagcttgagt gaaaaaagta aagaagaaac tggaataagt     6000

ttacaggatc ttctcttaga aatctacaga agtatagggg agccagatag tttgtatggc     6060

tgtggtggag ggaagatgtt acaacccatt actagactac gaacatatga acacgaagca     6120

atgtggggca aagccctagt aacatatgac ctcgaaacag caatcccctc atcaacacgc     6180

caggcaggaa tcattcaggc cttgcagaat ttgggactct gccatattct ttccgtctat     6240

ttaaaaggat tggattatga aaataaagac tggtgtcctg aactagaaga acttcattac     6300

caagcagcat ggaggaatat gcagtgggac cattgcactt ccgtcagcaa agaagtagaa     6360

ggaaccagtt accatgaatc attgtacaat gctctacaat ctctaagaga cagagaattc     6420

tctacatttt atgaaagtct caaatatgcc agagtaaaag aagtggaaga gatgtgtaag     6480

cgcagccttg agtctgtgta ttcgctctat cccacactta gcaggttgca ggccattgga     6540

gagctggaaa gcattgggga gcttttctca agatcagtca cacatagaca actctctgaa     6600

gtatatatta agtggcagaa acactcccag cttctcaagg acagtgattt tagttttcag     6660

gagcctatca tggctctacg cacagtcatt ttggagatcc tgatggaaaa ggaaatggac     6720

aactcacaaa gagaatgtat taaggacatt ctcaccaaac accttgtaga actctctata     6780

ctggccagaa ctttcaagaa cactcagctc cctgaaaggg caatatttca aattaaacag     6840

tacaattcag ttagctgtgg agtctctgag tggcagctgg aagaagcaca agtattctgg     6900

gcaaaaaagg agcagagtct tgccctgagt attctcaagc aaatgatcaa gaagttggat     6960

gccagctgtg cagcgaacaa tcccagccta aaacttacat acacagaatg tctgagggtt     7020

tgtggcaact ggttagcaga aacgtgctta gaaaatcctg cggtcatcat gcagacctat     7080

ctagaaaagg cagtagaagt tgctggaaat tatgatggag aaagtagtga tgagctaaga     7140

aatggaaaaa tgaaggcatt tctctcatta gcccggtttt cagatactca ataccaaaga     7200

attgaaaact acatgaaatc atcggaattt gaaaacaagc aagctctcct gaaaagagcc     7260

aaagaggaag taggtctcct tagggaacat aaaattcaga caaacagata cacagtaaag     7320

gttcagcgag agctggagtt ggatgaatta gccctgcgtg cactgaaaga ggatcgtaaa     7380

cgcttcttat gtaaagcagt tgaaaattat atcaactgct tattaagtgg agaagaacat     7440

gatatgtggg tattccgact ttgttccctc tggcttgaaa attctggagt ttctgaagtc     7500

aatggcatga tgaagagaga cggaatgaag attccaacat ataaattttt gcctcttatg     7560

taccaattgg ctgctagaat ggggaccaag atgatgggag gcctaggatt tcatgaagtc     7620

ctcaataatc taatctctag aatttcaatg gatcaccccc atcacacttt gtttattata     7680

ctggccttag caaatgcaaa cagagatgaa tttctgacta aaccagaggt agccagaaga     7740

agcagaataa ctaaaaatgt gcctaaacaa agctctcagc ttgatgagga tcgaacagag     7800

gctgcaaata gaataatatg tactatcaga agtaggagac ctcagatggt cagaagtgtt     7860

gaggcacttt gtgatgctta tattatatta gcaaacttag atgccactca gtggaagact     7920

cagagaaaag gcataaatat tccagcagac cagccaatta ctaaacttaa gaatttagaa     7980

gatgttgttg tccctactat ggaaattaag gtggaccaca caggagaata tggaaatctg     8040

gtgactatac agtcatttaa agcagaattt cgcttagcag gaggtgtaaa tttaccaaaa     8100

ataatagatt gtgtaggttc cgatggcaag gagaggagac agcttgttaa gggccgtgat     8160

gacctgagac aagatgctgt catgcaacag gtcttccaga tgtgtaatac attactgcag     8220

agaaacacgg aaactaggaa gaggaaatta actatctgta cttataaggt ggttcccctc     8280

tctcagcgaa gtggtgttct tgaatggtgc acaggaactg tccccattgg tgaatttctt     8340

gttaacaatg aagatggtgc tcataaaaga tacaggccaa atgatttcag tgcctttcag     8400

tgccaaaaga aaatgatgga ggtgcaaaaa aagtcttttg aagagaaata tgaagtcttc     8460

atggatgttt gccaaaattt tcaaccagtt ttccgttact tctgcatgga aaaattcttg     8520

gatccagcta tttggtttga gaagcgattg gcttatacgc gcagtgtagc tacttcttct     8580

attgttggtt acatacttgg acttggtgat agacatgtac agaatatctt gataaatgag     8640

cagtcagcag aacttgtaca tatagatcta ggtgttgctt ttgaacaggg caaaatcctt     8700

cctactcctg agacagttcc ttttagactc accagagata ttgtggatgg catgggcatt     8760

acgggtgttg aaggtgtctt cagaagatgc tgtgagaaaa ccatggaagt gatgagaaac     8820

tctcaggaaa ctctgttaac cattgtagag gtccttctat atgatccact ctttgactgg     8880

accatgaatc ctttgaaagc tttgtattta cagcagaggc cggaagatga aactgagctt     8940

caccctactc tgaatgcaga tgaccaagaa tgcaaacgaa atctcagtga tattgaccag     9000

agtttcaaca aagtagctga acgtgtctta atgagactac aagagaaact gaaaggagtg     9060

gaagaaggca ctgtgctcag tgttggtgga caagtgaatt tgctcataca gcaggccata     9120

gaccccaaaa atctcagccg acttttccca ggatggaaag cttgggtgtg a              9171


<210>  44
<211>  3056
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Met Ser Leu Val Leu Asn Asp Leu Leu Ile Cys Cys Arg Gln Leu Glu 
1               5                   10                  15      


His Asp Arg Ala Thr Glu Arg Lys Lys Glu Val Glu Lys Phe Lys Arg 
            20                  25                  30          


Leu Ile Arg Asp Pro Glu Thr Ile Lys His Leu Asp Arg His Ser Asp 
        35                  40                  45              


Ser Lys Gln Gly Lys Tyr Leu Asn Trp Asp Ala Val Phe Arg Phe Leu 
    50                  55                  60                  


Gln Lys Tyr Ile Gln Lys Glu Thr Glu Cys Leu Arg Ile Ala Lys Pro 
65                  70                  75                  80  


Asn Val Ser Ala Ser Thr Gln Ala Ser Arg Gln Lys Lys Met Gln Glu 
                85                  90                  95      


Ile Ser Ser Leu Val Lys Tyr Phe Ile Lys Cys Ala Asn Arg Arg Ala 
            100                 105                 110         


Pro Arg Leu Lys Cys Gln Glu Leu Leu Asn Tyr Ile Met Asp Thr Val 
        115                 120                 125             


Lys Asp Ser Ser Asn Gly Ala Ile Tyr Gly Ala Asp Cys Ser Asn Ile 
    130                 135                 140                 


Leu Leu Lys Asp Ile Leu Ser Val Arg Lys Tyr Trp Cys Glu Ile Ser 
145                 150                 155                 160 


Gln Gln Gln Trp Leu Glu Leu Phe Ser Val Tyr Phe Arg Leu Tyr Leu 
                165                 170                 175     


Lys Pro Ser Gln Asp Val His Arg Val Leu Val Ala Arg Ile Ile His 
            180                 185                 190         


Ala Val Thr Lys Gly Cys Cys Ser Gln Thr Asp Gly Leu Asn Ser Lys 
        195                 200                 205             


Phe Leu Asp Phe Phe Ser Lys Ala Ile Gln Cys Ala Arg Gln Glu Lys 
    210                 215                 220                 


Ser Ser Ser Gly Leu Asn His Ile Leu Ala Ala Leu Thr Ile Phe Leu 
225                 230                 235                 240 


Lys Thr Leu Ala Val Asn Phe Arg Ile Arg Val Cys Glu Leu Gly Asp 
                245                 250                 255     


Glu Ile Leu Pro Thr Leu Leu Tyr Ile Trp Thr Gln His Arg Leu Asn 
            260                 265                 270         


Asp Ser Leu Lys Glu Val Ile Ile Glu Leu Phe Gln Leu Gln Ile Tyr 
        275                 280                 285             


Ile His His Pro Lys Gly Ala Lys Thr Gln Glu Lys Gly Ala Tyr Glu 
    290                 295                 300                 


Ser Thr Lys Trp Arg Ser Ile Leu Tyr Asn Leu Tyr Asp Leu Leu Val 
305                 310                 315                 320 


Asn Glu Ile Ser His Ile Gly Ser Arg Gly Lys Tyr Ser Ser Gly Phe 
                325                 330                 335     


Arg Asn Ile Ala Val Lys Glu Asn Leu Ile Glu Leu Met Ala Asp Ile 
            340                 345                 350         


Cys His Gln Val Phe Asn Glu Asp Thr Arg Ser Leu Glu Ile Ser Gln 
        355                 360                 365             


Ser Tyr Thr Thr Thr Gln Arg Glu Ser Ser Asp Tyr Ser Val Pro Cys 
    370                 375                 380                 


Lys Arg Lys Lys Ile Glu Leu Gly Trp Glu Val Ile Lys Asp His Leu 
385                 390                 395                 400 


Gln Lys Ser Gln Asn Asp Phe Asp Leu Val Pro Trp Leu Gln Ile Ala 
                405                 410                 415     


Thr Gln Leu Ile Ser Lys Tyr Pro Ala Ser Leu Pro Asn Cys Glu Leu 
            420                 425                 430         


Ser Pro Leu Leu Met Ile Leu Ser Gln Leu Leu Pro Gln Gln Arg His 
        435                 440                 445             


Gly Glu Arg Thr Pro Tyr Val Leu Arg Cys Leu Thr Glu Val Ala Leu 
    450                 455                 460                 


Cys Gln Asp Lys Arg Ser Asn Leu Glu Ser Ser Gln Lys Ser Asp Leu 
465                 470                 475                 480 


Leu Lys Leu Trp Asn Lys Ile Trp Cys Ile Thr Phe Arg Gly Ile Ser 
                485                 490                 495     


Ser Glu Gln Ile Gln Ala Glu Asn Phe Gly Leu Leu Gly Ala Ile Ile 
            500                 505                 510         


Gln Gly Ser Leu Val Glu Val Asp Arg Glu Phe Trp Lys Leu Phe Thr 
        515                 520                 525             


Gly Ser Ala Cys Arg Pro Ser Cys Pro Ala Val Cys Cys Leu Thr Leu 
    530                 535                 540                 


Ala Leu Thr Thr Ser Ile Val Pro Gly Thr Val Lys Met Gly Ile Glu 
545                 550                 555                 560 


Gln Asn Met Cys Glu Val Asn Arg Ser Phe Ser Leu Lys Glu Ser Ile 
                565                 570                 575     


Met Lys Trp Leu Leu Phe Tyr Gln Leu Glu Gly Asp Leu Glu Asn Ser 
            580                 585                 590         


Thr Glu Val Pro Pro Ile Leu His Ser Asn Phe Pro His Leu Val Leu 
        595                 600                 605             


Glu Lys Ile Leu Val Ser Leu Thr Met Lys Asn Cys Lys Ala Ala Met 
    610                 615                 620                 


Asn Phe Phe Gln Ser Val Pro Glu Cys Glu His His Gln Lys Asp Lys 
625                 630                 635                 640 


Glu Glu Leu Ser Phe Ser Glu Val Glu Glu Leu Phe Leu Gln Thr Thr 
                645                 650                 655     


Phe Asp Lys Met Asp Phe Leu Thr Ile Val Arg Glu Cys Gly Ile Glu 
            660                 665                 670         


Lys His Gln Ser Ser Ile Gly Phe Ser Val His Gln Asn Leu Lys Glu 
        675                 680                 685             


Ser Leu Asp Arg Cys Leu Leu Gly Leu Ser Glu Gln Leu Leu Asn Asn 
    690                 695                 700                 


Tyr Ser Ser Glu Ile Thr Asn Ser Glu Thr Leu Val Arg Cys Ser Arg 
705                 710                 715                 720 


Leu Leu Val Gly Val Leu Gly Cys Tyr Cys Tyr Met Gly Val Ile Ala 
                725                 730                 735     


Glu Glu Glu Ala Tyr Lys Ser Glu Leu Phe Gln Lys Ala Lys Ser Leu 
            740                 745                 750         


Met Gln Cys Ala Gly Glu Ser Ile Thr Leu Phe Lys Asn Lys Thr Asn 
        755                 760                 765             


Glu Glu Phe Arg Ile Gly Ser Leu Arg Asn Met Met Gln Leu Cys Thr 
    770                 775                 780                 


Arg Cys Leu Ser Asn Cys Thr Lys Lys Ser Pro Asn Lys Ile Ala Ser 
785                 790                 795                 800 


Gly Phe Phe Leu Arg Leu Leu Thr Ser Lys Leu Met Asn Asp Ile Ala 
                805                 810                 815     


Asp Ile Cys Lys Ser Leu Ala Ser Phe Ile Lys Lys Pro Phe Asp Arg 
            820                 825                 830         


Gly Glu Val Glu Ser Met Glu Asp Asp Thr Asn Gly Asn Leu Met Glu 
        835                 840                 845             


Val Glu Asp Gln Ser Ser Met Asn Leu Phe Asn Asp Tyr Pro Asp Ser 
    850                 855                 860                 


Ser Val Ser Asp Ala Asn Glu Pro Gly Glu Ser Gln Ser Thr Ile Gly 
865                 870                 875                 880 


Ala Ile Asn Pro Leu Ala Glu Glu Tyr Leu Ser Lys Gln Asp Leu Leu 
                885                 890                 895     


Phe Leu Asp Met Leu Lys Phe Leu Cys Leu Cys Val Thr Thr Ala Gln 
            900                 905                 910         


Thr Asn Thr Val Ser Phe Arg Ala Ala Asp Ile Arg Arg Lys Leu Leu 
        915                 920                 925             


Met Leu Ile Asp Ser Ser Thr Leu Glu Pro Thr Lys Ser Leu His Leu 
    930                 935                 940                 


His Met Tyr Leu Met Leu Leu Lys Glu Leu Pro Gly Glu Glu Tyr Pro 
945                 950                 955                 960 


Leu Pro Met Glu Asp Val Leu Glu Leu Leu Lys Pro Leu Ser Asn Val 
                965                 970                 975     


Cys Ser Leu Tyr Arg Arg Asp Gln Asp Val Cys Lys Thr Ile Leu Asn 
            980                 985                 990         


His Val Leu His Val Val Lys Asn  Leu Gly Gln Ser Asn  Met Asp Ser 
        995                 1000                 1005             


Glu Asn  Thr Arg Asp Ala Gln  Gly Gln Phe Leu Thr  Val Ile Gly 
    1010                 1015                 1020             


Ala Phe  Trp His Leu Thr Lys  Glu Arg Lys Tyr Ile  Phe Ser Val 
    1025                 1030                 1035             


Arg Met  Ala Leu Val Asn Cys  Leu Lys Thr Leu Leu  Glu Ala Asp 
    1040                 1045                 1050             


Pro Tyr  Ser Lys Trp Ala Ile  Leu Asn Val Met Gly  Lys Asp Phe 
    1055                 1060                 1065             


Pro Val  Asn Glu Val Phe Thr  Gln Phe Leu Ala Asp  Asn His His 
    1070                 1075                 1080             


Gln Val  Arg Met Leu Ala Ala  Glu Ser Ile Asn Arg  Leu Phe Gln 
    1085                 1090                 1095             


Asp Thr  Lys Gly Asp Ser Ser  Arg Leu Leu Lys Ala  Leu Pro Leu 
    1100                 1105                 1110             


Lys Leu  Gln Gln Thr Ala Phe  Glu Asn Ala Tyr Leu  Lys Ala Gln 
    1115                 1120                 1125             


Glu Gly  Met Arg Glu Met Ser  His Ser Ala Glu Asn  Pro Glu Thr 
    1130                 1135                 1140             


Leu Asp  Glu Ile Tyr Asn Arg  Lys Ser Val Leu Leu  Thr Leu Ile 
    1145                 1150                 1155             


Ala Val  Val Leu Ser Cys Ser  Pro Ile Cys Glu Lys  Gln Ala Leu 
    1160                 1165                 1170             


Phe Ala  Leu Cys Lys Ser Val  Lys Glu Asn Gly Leu  Glu Pro His 
    1175                 1180                 1185             


Leu Val  Lys Lys Val Leu Glu  Lys Val Ser Glu Thr  Phe Gly Tyr 
    1190                 1195                 1200             


Arg Arg  Leu Glu Asp Phe Met  Ala Ser His Leu Asp  Tyr Leu Val 
    1205                 1210                 1215             


Leu Glu  Trp Leu Asn Leu Gln  Asp Thr Glu Tyr Asn  Leu Ser Ser 
    1220                 1225                 1230             


Phe Pro  Phe Ile Leu Leu Asn  Tyr Thr Asn Ile Glu  Asp Phe Tyr 
    1235                 1240                 1245             


Arg Ser  Cys Tyr Lys Val Leu  Ile Pro His Leu Val  Ile Arg Ser 
    1250                 1255                 1260             


His Phe  Asp Glu Val Lys Ser  Ile Ala Asn Gln Ile  Gln Glu Asp 
    1265                 1270                 1275             


Trp Lys  Ser Leu Leu Thr Asp  Cys Phe Pro Lys Ile  Leu Val Asn 
    1280                 1285                 1290             


Ile Leu  Pro Tyr Phe Ala Tyr  Glu Gly Thr Arg Asp  Ser Gly Met 
    1295                 1300                 1305             


Ala Gln  Gln Arg Glu Thr Ala  Thr Lys Val Tyr Asp  Met Leu Lys 
    1310                 1315                 1320             


Ser Glu  Asn Leu Leu Gly Lys  Gln Ile Asp His Leu  Phe Ile Ser 
    1325                 1330                 1335             


Asn Leu  Pro Glu Ile Val Val  Glu Leu Leu Met Thr  Leu His Glu 
    1340                 1345                 1350             


Pro Ala  Asn Ser Ser Ala Ser  Gln Ser Thr Asp Leu  Cys Asp Phe 
    1355                 1360                 1365             


Ser Gly  Asp Leu Asp Pro Ala  Pro Asn Pro Pro His  Phe Pro Ser 
    1370                 1375                 1380             


His Val  Ile Lys Ala Thr Phe  Ala Tyr Ile Ser Asn  Cys His Lys 
    1385                 1390                 1395             


Thr Lys  Leu Lys Ser Ile Leu  Glu Ile Leu Ser Lys  Ser Pro Asp 
    1400                 1405                 1410             


Ser Tyr  Gln Lys Ile Leu Leu  Ala Ile Cys Glu Gln  Ala Ala Glu 
    1415                 1420                 1425             


Thr Asn  Asn Val Tyr Lys Lys  His Arg Ile Leu Lys  Ile Tyr His 
    1430                 1435                 1440             


Leu Phe  Val Ser Leu Leu Leu  Lys Asp Ile Lys Ser  Gly Leu Gly 
    1445                 1450                 1455             


Gly Ala  Trp Ala Phe Val Leu  Arg Asp Val Ile Tyr  Thr Leu Ile 
    1460                 1465                 1470             


His Tyr  Ile Asn Gln Arg Pro  Ser Cys Ile Met Asp  Val Ser Leu 
    1475                 1480                 1485             


Arg Ser  Phe Ser Leu Cys Cys  Asp Leu Leu Ser Gln  Val Cys Gln 
    1490                 1495                 1500             


Thr Ala  Val Thr Tyr Cys Lys  Asp Ala Leu Glu Asn  His Leu His 
    1505                 1510                 1515             


Val Ile  Val Gly Thr Leu Ile  Pro Leu Val Tyr Glu  Gln Val Glu 
    1520                 1525                 1530             


Val Gln  Lys Gln Val Leu Asp  Leu Leu Lys Tyr Leu  Val Ile Asp 
    1535                 1540                 1545             


Asn Lys  Asp Asn Glu Asn Leu  Tyr Ile Thr Ile Lys  Leu Leu Asp 
    1550                 1555                 1560             


Pro Phe  Pro Asp His Val Val  Phe Lys Asp Leu Arg  Ile Thr Gln 
    1565                 1570                 1575             


Gln Lys  Ile Lys Tyr Ser Arg  Gly Pro Phe Ser Leu  Leu Glu Glu 
    1580                 1585                 1590             


Ile Asn  His Phe Leu Ser Val  Ser Val Tyr Asp Ala  Leu Pro Leu 
    1595                 1600                 1605             


Thr Arg  Leu Glu Gly Leu Lys  Asp Leu Arg Arg Gln  Leu Glu Leu 
    1610                 1615                 1620             


His Lys  Asp Gln Met Val Asp  Ile Met Arg Ala Ser  Gln Asp Asn 
    1625                 1630                 1635             


Pro Gln  Asp Gly Ile Met Val  Lys Leu Val Val Asn  Leu Leu Gln 
    1640                 1645                 1650             


Leu Ser  Lys Met Ala Ile Asn  His Thr Gly Glu Lys  Glu Val Leu 
    1655                 1660                 1665             


Glu Ala  Val Gly Ser Cys Leu  Gly Glu Val Gly Pro  Ile Asp Phe 
    1670                 1675                 1680             


Ser Thr  Ile Ala Ile Gln His  Ser Lys Asp Ala Ser  Tyr Thr Lys 
    1685                 1690                 1695             


Ala Leu  Lys Leu Phe Glu Asp  Lys Glu Leu Gln Trp  Thr Phe Ile 
    1700                 1705                 1710             


Met Leu  Thr Tyr Leu Asn Asn  Thr Leu Val Glu Asp  Cys Val Lys 
    1715                 1720                 1725             


Val Arg  Ser Ala Ala Val Thr  Cys Leu Lys Asn Ile  Leu Ala Thr 
    1730                 1735                 1740             


Lys Thr  Gly His Ser Phe Trp  Glu Ile Tyr Lys Met  Thr Thr Asp 
    1745                 1750                 1755             


Pro Met  Leu Ala Tyr Leu Gln  Pro Phe Arg Thr Ser  Arg Lys Lys 
    1760                 1765                 1770             


Phe Leu  Glu Val Pro Arg Phe  Asp Lys Glu Asn Pro  Phe Glu Gly 
    1775                 1780                 1785             


Leu Asp  Asp Ile Asn Leu Trp  Ile Pro Leu Ser Glu  Asn His Asp 
    1790                 1795                 1800             


Ile Trp  Ile Lys Thr Leu Thr  Cys Ala Phe Leu Asp  Ser Gly Gly 
    1805                 1810                 1815             


Thr Lys  Cys Glu Ile Leu Gln  Leu Leu Lys Pro Met  Cys Glu Val 
    1820                 1825                 1830             


Lys Thr  Asp Phe Cys Gln Thr  Val Leu Pro Tyr Leu  Ile His Asp 
    1835                 1840                 1845             


Ile Leu  Leu Gln Asp Thr Asn  Glu Ser Trp Arg Asn  Leu Leu Ser 
    1850                 1855                 1860             


Thr His  Val Gln Gly Phe Phe  Thr Ser Cys Leu Arg  His Phe Ser 
    1865                 1870                 1875             


Gln Thr  Ser Arg Ser Thr Thr  Pro Ala Asn Leu Asp  Ser Glu Ser 
    1880                 1885                 1890             


Glu His  Phe Phe Arg Cys Cys  Leu Asp Lys Lys Ser  Gln Arg Thr 
    1895                 1900                 1905             


Met Leu  Ala Val Val Asp Tyr  Met Arg Arg Gln Lys  Arg Pro Ser 
    1910                 1915                 1920             


Ser Gly  Thr Ile Phe Asn Asp  Ala Phe Trp Leu Asp  Leu Asn Tyr 
    1925                 1930                 1935             


Leu Glu  Val Ala Lys Val Ala  Gln Ser Cys Ala Ala  His Phe Thr 
    1940                 1945                 1950             


Ala Leu  Leu Tyr Ala Glu Ile  Tyr Ala Asp Lys Lys  Ser Met Asp 
    1955                 1960                 1965             


Asp Gln  Glu Lys Arg Ser Leu  Ala Phe Glu Glu Gly  Ser Gln Ser 
    1970                 1975                 1980             


Thr Thr  Ile Ser Ser Leu Ser  Glu Lys Ser Lys Glu  Glu Thr Gly 
    1985                 1990                 1995             


Ile Ser  Leu Gln Asp Leu Leu  Leu Glu Ile Tyr Arg  Ser Ile Gly 
    2000                 2005                 2010             


Glu Pro  Asp Ser Leu Tyr Gly  Cys Gly Gly Gly Lys  Met Leu Gln 
    2015                 2020                 2025             


Pro Ile  Thr Arg Leu Arg Thr  Tyr Glu His Glu Ala  Met Trp Gly 
    2030                 2035                 2040             


Lys Ala  Leu Val Thr Tyr Asp  Leu Glu Thr Ala Ile  Pro Ser Ser 
    2045                 2050                 2055             


Thr Arg  Gln Ala Gly Ile Ile  Gln Ala Leu Gln Asn  Leu Gly Leu 
    2060                 2065                 2070             


Cys His  Ile Leu Ser Val Tyr  Leu Lys Gly Leu Asp  Tyr Glu Asn 
    2075                 2080                 2085             


Lys Asp  Trp Cys Pro Glu Leu  Glu Glu Leu His Tyr  Gln Ala Ala 
    2090                 2095                 2100             


Trp Arg  Asn Met Gln Trp Asp  His Cys Thr Ser Val  Ser Lys Glu 
    2105                 2110                 2115             


Val Glu  Gly Thr Ser Tyr His  Glu Ser Leu Tyr Asn  Ala Leu Gln 
    2120                 2125                 2130             


Ser Leu  Arg Asp Arg Glu Phe  Ser Thr Phe Tyr Glu  Ser Leu Lys 
    2135                 2140                 2145             


Tyr Ala  Arg Val Lys Glu Val  Glu Glu Met Cys Lys  Arg Ser Leu 
    2150                 2155                 2160             


Glu Ser  Val Tyr Ser Leu Tyr  Pro Thr Leu Ser Arg  Leu Gln Ala 
    2165                 2170                 2175             


Ile Gly  Glu Leu Glu Ser Ile  Gly Glu Leu Phe Ser  Arg Ser Val 
    2180                 2185                 2190             


Thr His  Arg Gln Leu Ser Glu  Val Tyr Ile Lys Trp  Gln Lys His 
    2195                 2200                 2205             


Ser Gln  Leu Leu Lys Asp Ser  Asp Phe Ser Phe Gln  Glu Pro Ile 
    2210                 2215                 2220             


Met Ala  Leu Arg Thr Val Ile  Leu Glu Ile Leu Met  Glu Lys Glu 
    2225                 2230                 2235             


Met Asp  Asn Ser Gln Arg Glu  Cys Ile Lys Asp Ile  Leu Thr Lys 
    2240                 2245                 2250             


His Leu  Val Glu Leu Ser Ile  Leu Ala Arg Thr Phe  Lys Asn Thr 
    2255                 2260                 2265             


Gln Leu  Pro Glu Arg Ala Ile  Phe Gln Ile Lys Gln  Tyr Asn Ser 
    2270                 2275                 2280             


Val Ser  Cys Gly Val Ser Glu  Trp Gln Leu Glu Glu  Ala Gln Val 
    2285                 2290                 2295             


Phe Trp  Ala Lys Lys Glu Gln  Ser Leu Ala Leu Ser  Ile Leu Lys 
    2300                 2305                 2310             


Gln Met  Ile Lys Lys Leu Asp  Ala Ser Cys Ala Ala  Asn Asn Pro 
    2315                 2320                 2325             


Ser Leu  Lys Leu Thr Tyr Thr  Glu Cys Leu Arg Val  Cys Gly Asn 
    2330                 2335                 2340             


Trp Leu  Ala Glu Thr Cys Leu  Glu Asn Pro Ala Val  Ile Met Gln 
    2345                 2350                 2355             


Thr Tyr  Leu Glu Lys Ala Val  Glu Val Ala Gly Asn  Tyr Asp Gly 
    2360                 2365                 2370             


Glu Ser  Ser Asp Glu Leu Arg  Asn Gly Lys Met Lys  Ala Phe Leu 
    2375                 2380                 2385             


Ser Leu  Ala Arg Phe Ser Asp  Thr Gln Tyr Gln Arg  Ile Glu Asn 
    2390                 2395                 2400             


Tyr Met  Lys Ser Ser Glu Phe  Glu Asn Lys Gln Ala  Leu Leu Lys 
    2405                 2410                 2415             


Arg Ala  Lys Glu Glu Val Gly  Leu Leu Arg Glu His  Lys Ile Gln 
    2420                 2425                 2430             


Thr Asn  Arg Tyr Thr Val Lys  Val Gln Arg Glu Leu  Glu Leu Asp 
    2435                 2440                 2445             


Glu Leu  Ala Leu Arg Ala Leu  Lys Glu Asp Arg Lys  Arg Phe Leu 
    2450                 2455                 2460             


Cys Lys  Ala Val Glu Asn Tyr  Ile Asn Cys Leu Leu  Ser Gly Glu 
    2465                 2470                 2475             


Glu His  Asp Met Trp Val Phe  Arg Leu Cys Ser Leu  Trp Leu Glu 
    2480                 2485                 2490             


Asn Ser  Gly Val Ser Glu Val  Asn Gly Met Met Lys  Arg Asp Gly 
    2495                 2500                 2505             


Met Lys  Ile Pro Thr Tyr Lys  Phe Leu Pro Leu Met  Tyr Gln Leu 
    2510                 2515                 2520             


Ala Ala  Arg Met Gly Thr Lys  Met Met Gly Gly Leu  Gly Phe His 
    2525                 2530                 2535             


Glu Val  Leu Asn Asn Leu Ile  Ser Arg Ile Ser Met  Asp His Pro 
    2540                 2545                 2550             


His His  Thr Leu Phe Ile Ile  Leu Ala Leu Ala Asn  Ala Asn Arg 
    2555                 2560                 2565             


Asp Glu  Phe Leu Thr Lys Pro  Glu Val Ala Arg Arg  Ser Arg Ile 
    2570                 2575                 2580             


Thr Lys  Asn Val Pro Lys Gln  Ser Ser Gln Leu Asp  Glu Asp Arg 
    2585                 2590                 2595             


Thr Glu  Ala Ala Asn Arg Ile  Ile Cys Thr Ile Arg  Ser Arg Arg 
    2600                 2605                 2610             


Pro Gln  Met Val Arg Ser Val  Glu Ala Leu Cys Asp  Ala Tyr Ile 
    2615                 2620                 2625             


Ile Leu  Ala Asn Leu Asp Ala  Thr Gln Trp Lys Thr  Gln Arg Lys 
    2630                 2635                 2640             


Gly Ile  Asn Ile Pro Ala Asp  Gln Pro Ile Thr Lys  Leu Lys Asn 
    2645                 2650                 2655             


Leu Glu  Asp Val Val Val Pro  Thr Met Glu Ile Lys  Val Asp His 
    2660                 2665                 2670             


Thr Gly  Glu Tyr Gly Asn Leu  Val Thr Ile Gln Ser  Phe Lys Ala 
    2675                 2680                 2685             


Glu Phe  Arg Leu Ala Gly Gly  Val Asn Leu Pro Lys  Ile Ile Asp 
    2690                 2695                 2700             


Cys Val  Gly Ser Asp Gly Lys  Glu Arg Arg Gln Leu  Val Lys Gly 
    2705                 2710                 2715             


Arg Asp  Asp Leu Arg Gln Asp  Ala Val Met Gln Gln  Val Phe Gln 
    2720                 2725                 2730             


Met Cys  Asn Thr Leu Leu Gln  Arg Asn Thr Glu Thr  Arg Lys Arg 
    2735                 2740                 2745             


Lys Leu  Thr Ile Cys Thr Tyr  Lys Val Val Pro Leu  Ser Gln Arg 
    2750                 2755                 2760             


Ser Gly  Val Leu Glu Trp Cys  Thr Gly Thr Val Pro  Ile Gly Glu 
    2765                 2770                 2775             


Phe Leu  Val Asn Asn Glu Asp  Gly Ala His Lys Arg  Tyr Arg Pro 
    2780                 2785                 2790             


Asn Asp  Phe Ser Ala Phe Gln  Cys Gln Lys Lys Met  Met Glu Val 
    2795                 2800                 2805             


Gln Lys  Lys Ser Phe Glu Glu  Lys Tyr Glu Val Phe  Met Asp Val 
    2810                 2815                 2820             


Cys Gln  Asn Phe Gln Pro Val  Phe Arg Tyr Phe Cys  Met Glu Lys 
    2825                 2830                 2835             


Phe Leu  Asp Pro Ala Ile Trp  Phe Glu Lys Arg Leu  Ala Tyr Thr 
    2840                 2845                 2850             


Arg Ser  Val Ala Thr Ser Ser  Ile Val Gly Tyr Ile  Leu Gly Leu 
    2855                 2860                 2865             


Gly Asp  Arg His Val Gln Asn  Ile Leu Ile Asn Glu  Gln Ser Ala 
    2870                 2875                 2880             


Glu Leu  Val His Ile Asp Leu  Gly Val Ala Phe Glu  Gln Gly Lys 
    2885                 2890                 2895             


Ile Leu  Pro Thr Pro Glu Thr  Val Pro Phe Arg Leu  Thr Arg Asp 
    2900                 2905                 2910             


Ile Val  Asp Gly Met Gly Ile  Thr Gly Val Glu Gly  Val Phe Arg 
    2915                 2920                 2925             


Arg Cys  Cys Glu Lys Thr Met  Glu Val Met Arg Asn  Ser Gln Glu 
    2930                 2935                 2940             


Thr Leu  Leu Thr Ile Val Glu  Val Leu Leu Tyr Asp  Pro Leu Phe 
    2945                 2950                 2955             


Asp Trp  Thr Met Asn Pro Leu  Lys Ala Leu Tyr Leu  Gln Gln Arg 
    2960                 2965                 2970             


Pro Glu  Asp Glu Thr Glu Leu  His Pro Thr Leu Asn  Ala Asp Asp 
    2975                 2980                 2985             


Gln Glu  Cys Lys Arg Asn Leu  Ser Asp Ile Asp Gln  Ser Phe Asn 
    2990                 2995                 3000             


Lys Val  Ala Glu Arg Val Leu  Met Arg Leu Gln Glu  Lys Leu Lys 
    3005                 3010                 3015             


Gly Val  Glu Glu Gly Thr Val  Leu Ser Val Gly Gly  Gln Val Asn 
    3020                 3025                 3030             


Leu Leu  Ile Gln Gln Ala Ile  Asp Pro Lys Asn Leu  Ser Arg Leu 
    3035                 3040                 3045             


Phe Pro  Gly Trp Lys Ala Trp  Val 
    3050                 3055     


<210>  45
<211>  2346
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45
atggctactc aagctgattt gatggagttg gacatggcca tggaaccaga cagaaaagcg       60

gctgttagtc actggcagca acagtcttac ctggactctg gaatccattc tggtgccact      120

accacagctc cttctctgag tggtaaaggc aatcctgagg aagaggatgt ggatacctcc      180

caagtcctgt atgagtggga acagggattt tctcagtcct tcactcaaga acaagtagct      240

gatattgatg gacagtatgc aatgactcga gctcagaggg tacgagctgc tatgttccct      300

gagacattag atgagggcat gcagatccca tctacacagt ttgatgctgc tcatcccact      360

aatgtccagc gtttggctga accatcacag atgctgaaac atgcagttgt aaacttgatt      420

aactatcaag atgatgcaga acttgccaca cgtgcaatcc ctgaactgac aaaactgcta      480

aatgacgagg accaggtggt ggttaataag gctgcagtta tggtccatca gctttctaaa      540

aaggaagctt ccagacacgc tatcatgcgt tctcctcaga tggtgtctgc tattgtacgt      600

accatgcaga atacaaatga tgtagaaaca gctcgttgta ccgctgggac cttgcataac      660

ctttcccatc atcgtgaggg cttactggcc atctttaagt ctggaggcat tcctgccctg      720

gtgaaaatgc ttggttcacc agtggattct gtgttgtttt atgccattac aactctccac      780

aaccttttat tacatcaaga aggagctaaa atggcagtgc gtttagctgg tgggctgcag      840

aaaatggttg ccttgctcaa caaaacaaat gttaaattct tggctattac gacagactgc      900

cttcaaattt tagcttatgg caaccaagaa agcaagctca tcatactggc tagtggtgga      960

ccccaagctt tagtaaatat aatgaggacc tatacttacg aaaaactact gtggaccaca     1020

agcagagtgc tgaaggtgct atctgtctgc tctagtaata agccggctat tgtagaagct     1080

ggtggaatgc aagctttagg acttcacctg acagatccaa gtcaacgtct tgttcagaac     1140

tgtctttgga ctctcaggaa tctttcagat gctgcaacta aacaggaagg gatggaaggt     1200

ctccttggga ctcttgttca gcttctgggt tcagatgata taaatgtggt cacctgtgca     1260

gctggaattc tttctaacct cacttgcaat aattataaga acaagatgat ggtctgccaa     1320

gtgggtggta tagaggctct tgtgcgtact gtccttcggg ctggtgacag ggaagacatc     1380

actgagcctg ccatctgtgc tcttcgtcat ctgaccagcc gacaccaaga agcagagatg     1440

gcccagaatg cagttcgcct tcactatgga ctaccagttg tggttaagct cttacaccca     1500

ccatcccact ggcctctgat aaaggctact gttggattga ttcgaaatct tgccctttgt     1560

cccgcaaatc atgcaccttt gcgtgagcag ggtgccattc cacgactagt tcagttgctt     1620

gttcgtgcac atcaggatac ccagcgccgt acgtccatgg gtgggacaca gcagcaattt     1680

gtggaggggg tccgcatgga agaaatagtt gaaggttgta ccggagccct tcacatccta     1740

gctcgggatg ttcacaaccg aattgttatc agaggactaa ataccattcc attgtttgtg     1800

cagctgcttt attctcccat tgaaaacatc caaagagtag ctgcaggggt cctctgtgaa     1860

cttgctcagg acaaggaagc tgcagaagct attgaagctg agggagccac agctcctctg     1920

acagagttac ttcactctag gaatgaaggt gtggcgacat atgcagctgc tgttttgttc     1980

cgaatgtctg aggacaagcc acaagattac aagaaacggc tttcagttga gctgaccagc     2040

tctctcttca gaacagagcc aatggcttgg aatgagactg ctgatcttgg acttgatatt     2100

ggtgcccagg gagaacccct tggatatcgc caggatgatc ctagctatcg ttcttttcac     2160

tctggtggat atggccagga tgccttgggt atggacccca tgatggaaca tgagatgggt     2220

ggccaccacc ctggtgctga ctatccagtt gatgggctgc cagatctggg gcatgcccag     2280

gacctcatgg atgggctgcc tccaggtgac agcaatcagc tggcctggtt tgatactgac     2340

ctgtaa                                                                2346


<210>  46
<211>  781
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  47
<211>  4029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47
atgagggcga acgacgctct gcaggtgctg ggcttgcttt tcagcctggc ccggggctcc       60

gaggtgggca actctcaggc agtgtgtcct gggactctga atggcctgag tgtgaccggc      120

gatgctgaga accaatacca gacactgtac aagctctacg agaggtgtga ggtggtgatg      180

gggaaccttg agattgtgct cacgggacac aatgccgacc tctccttcct gcagtggatt      240

cgagaagtga caggctatgt cctcgtggcc atgaatgaat tctctactct accattgccc      300

aacctccgcg tggtgcgagg gacccaggtc tacgatggga agtttgccat cttcgtcatg      360

ttgaactata acaccaactc cagccacgct ctgcgccagc tccgcttgac tcagctcacc      420

gagattctgt cagggggtgt ttatattgag aagaacgata agctttgtca catggacaca      480

attgactgga gggacatcgt gagggaccga gatgctgaga tagtggtgaa ggacaatggc      540

agaagctgtc ccccctgtca tgaggtttgc aaggggcgat gctggggtcc tggatcagaa      600

gactgccaga cattgaccaa gaccatctgt gctcctcagt gtaatggtca ctgctttggg      660

cccaacccca accagtgctg ccatgatgag tgtgccgggg gctgctcagg ccctcaggac      720

acagactgct ttgcctgccg gcacttcaat gacagtggag cctgtgtacc tcgctgtcca      780

cagcctcttg tctacaacaa gctaactttc cagctggaac ccaatcccca caccaagtat      840

cagtatggag gagtttgtgt agccagctgt ccccataact ttgtggtgga tcaaacatcc      900

tgtgtcaggg cctgtcctcc tgacaagatg gaagtagata aaaatgggct caagatgtgt      960

gagccttgtg ggggactatg tcccaaagcc tgtgagggaa caggctctgg gagccgcttc     1020

cagactgtgg actcgagcaa cattgatgga tttgtgaact gcaccaagat cctgggcaac     1080

ctggactttc tgatcaccgg cctcaatgga gacccctggc acaagatccc tgccctggac     1140

ccagagaagc tcaatgtctt ccggacagta cgggagatca caggttacct gaacatccag     1200

tcctggccgc cccacatgca caacttcagt gttttttcca atttgacaac cattggaggc     1260

agaagcctct acaaccgggg cttctcattg ttgatcatga agaacttgaa tgtcacatct     1320

ctgggcttcc gatccctgaa ggaaattagt gctgggcgta tctatataag tgccaatagg     1380

cagctctgct accaccactc tttgaactgg accaaggtgc ttcgggggcc tacggaagag     1440

cgactagaca tcaagcataa tcggccgcgc agagactgcg tggcagaggg caaagtgtgt     1500

gacccactgt gctcctctgg gggatgctgg ggcccaggcc ctggtcagtg cttgtcctgt     1560

cgaaattata gccgaggagg tgtctgtgtg acccactgca actttctgaa tggggagcct     1620

cgagaatttg cccatgaggc cgaatgcttc tcctgccacc cggaatgcca acccatggag     1680

ggcactgcca catgcaatgg ctcgggctct gatacttgtg ctcaatgtgc ccattttcga     1740

gatgggcccc actgtgtgag cagctgcccc catggagtcc taggtgccaa gggcccaatc     1800

tacaagtacc cagatgttca gaatgaatgt cggccctgcc atgagaactg cacccagggg     1860

tgtaaaggac cagagcttca agactgttta ggacaaacac tggtgctgat cggcaaaacc     1920

catctgacaa tggctttgac agtgatagca ggattggtag tgattttcat gatgctgggc     1980

ggcacttttc tctactggcg tgggcgccgg attcagaata aaagggctat gaggcgatac     2040

ttggaacggg gtgagagcat agagcctctg gaccccagtg agaaggctaa caaagtcttg     2100

gccagaatct tcaaagagac agagctaagg aagcttaaag tgcttggctc gggtgtcttt     2160

ggaactgtgc acaaaggagt gtggatccct gagggtgaat caatcaagat tccagtctgc     2220

attaaagtca ttgaggacaa gagtggacgg cagagttttc aagctgtgac agatcatatg     2280

ctggccattg gcagcctgga ccatgcccac attgtaaggc tgctgggact atgcccaggg     2340

tcatctctgc agcttgtcac tcaatatttg cctctgggtt ctctgctgga tcatgtgaga     2400

caacaccggg gggcactggg gccacagctg ctgctcaact ggggagtaca aattgccaag     2460

ggaatgtact accttgagga acatggtatg gtgcatagaa acctggctgc ccgaaacgtg     2520

ctactcaagt cacccagtca ggttcaggtg gcagattttg gtgtggctga cctgctgcct     2580

cctgatgata agcagctgct atacagtgag gccaagactc caattaagtg gatggccctt     2640

gagagtatcc actttgggaa atacacacac cagagtgatg tctggagcta tggtgtgaca     2700

gtttgggagt tgatgacctt cggggcagag ccctatgcag ggctacgatt ggctgaagta     2760

ccagacctgc tagagaaggg ggagcggttg gcacagcccc agatctgcac aattgatgtc     2820

tacatggtga tggtcaagtg ttggatgatt gatgagaaca ttcgcccaac ctttaaagaa     2880

ctagccaatg agttcaccag gatggcccga gacccaccac ggtatctggt cataaagaga     2940

gagagtgggc ctggaatagc ccctgggcca gagccccatg gtctgacaaa caagaagcta     3000

gaggaagtag agctggagcc agaactagac ctagacctag acttggaagc agaggaggac     3060

aacctggcaa ccaccacact gggctccgcc ctcagcctac cagttggaac acttaatcgg     3120

ccacgtggga gccagagcct tttaagtcca tcatctggat acatgcccat gaaccagggt     3180

aatcttgggg agtcttgcca ggagtctgca gtttctggga gcagtgaacg gtgcccccgt     3240

ccagtctctc tacacccaat gccacgggga tgcctggcat cagagtcatc agaggggcat     3300

gtaacaggct ctgaggctga gctccaggag aaagtgtcaa tgtgtaggag ccggagcagg     3360

agccggagcc cacggccacg cggagatagc gcctaccatt cccagcgcca cagtctgctg     3420

actcctgtta ccccactctc cccacccggg ttagaggaag aggatgtcaa cggttatgtc     3480

atgccagata cacacctcaa aggtactccc tcctcccggg aaggcaccct ttcttcagtg     3540

ggtctcagtt ctgtcctggg tactgaagaa gaagatgaag atgaggagta tgaatacatg     3600

aaccggagga gaaggcacag tccacctcat ccccctaggc caagttccct tgaggagctg     3660

ggttatgagt acatggatgt ggggtcagac ctcagtgcct ctctgggcag cacacagagt     3720

tgcccactcc accctgtacc catcatgccc actgcaggca caactccaga tgaagactat     3780

gaatatatga atcggcaacg agatggaggt ggtcctgggg gtgattatgc agccatgggg     3840

gcctgcccag catctgagca agggtatgaa gagatgagag cttttcaggg gcctggacat     3900

caggcccccc atgtccatta tgcccgccta aaaactctac gtagcttaga ggctacagac     3960

tctgcctttg ataaccctga ttactggcat agcaggcttt tccccaaggc taatgcccag     4020

agaacgtaa                                                             4029


<210>  48
<211>  1342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Met Arg Ala Asn Asp Ala Leu Gln Val Leu Gly Leu Leu Phe Ser Leu 
1               5                   10                  15      


Ala Arg Gly Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr 
            20                  25                  30          


Leu Asn Gly Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr 
        35                  40                  45              


Leu Tyr Lys Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu 
    50                  55                  60                  


Ile Val Leu Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile 
65                  70                  75                  80  


Arg Glu Val Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr 
                85                  90                  95      


Leu Pro Leu Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp 
            100                 105                 110         


Gly Lys Phe Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser 
        115                 120                 125             


His Ala Leu Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser 
    130                 135                 140                 


Gly Gly Val Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr 
145                 150                 155                 160 


Ile Asp Trp Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val 
                165                 170                 175     


Lys Asp Asn Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly 
            180                 185                 190         


Arg Cys Trp Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr 
        195                 200                 205             


Ile Cys Ala Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn 
    210                 215                 220                 


Gln Cys Cys His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp 
225                 230                 235                 240 


Thr Asp Cys Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val 
                245                 250                 255     


Pro Arg Cys Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu 
            260                 265                 270         


Glu Pro Asn Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala 
        275                 280                 285             


Ser Cys Pro His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala 
    290                 295                 300                 


Cys Pro Pro Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys 
305                 310                 315                 320 


Glu Pro Cys Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser 
                325                 330                 335     


Gly Ser Arg Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val 
            340                 345                 350         


Asn Cys Thr Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu 
        355                 360                 365             


Asn Gly Asp Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu 
    370                 375                 380                 


Asn Val Phe Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln 
385                 390                 395                 400 


Ser Trp Pro Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr 
                405                 410                 415     


Thr Ile Gly Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile 
            420                 425                 430         


Met Lys Asn Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu 
        435                 440                 445             


Ile Ser Ala Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr 
    450                 455                 460                 


His His Ser Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu 
465                 470                 475                 480 


Arg Leu Asp Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu 
                485                 490                 495     


Gly Lys Val Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro 
            500                 505                 510         


Gly Pro Gly Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val 
        515                 520                 525             


Cys Val Thr His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala 
    530                 535                 540                 


His Glu Ala Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu 
545                 550                 555                 560 


Gly Thr Ala Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys 
                565                 570                 575     


Ala His Phe Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly 
            580                 585                 590         


Val Leu Gly Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn 
        595                 600                 605             


Glu Cys Arg Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro 
    610                 615                 620                 


Glu Leu Gln Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr 
625                 630                 635                 640 


His Leu Thr Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe 
                645                 650                 655     


Met Met Leu Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln 
            660                 665                 670         


Asn Lys Arg Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu 
        675                 680                 685             


Pro Leu Asp Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe 
    690                 695                 700                 


Lys Glu Thr Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe 
705                 710                 715                 720 


Gly Thr Val His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys 
                725                 730                 735     


Ile Pro Val Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser 
            740                 745                 750         


Phe Gln Ala Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His 
        755                 760                 765             


Ala His Ile Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln 
    770                 775                 780                 


Leu Val Thr Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg 
785                 790                 795                 800 


Gln His Arg Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val 
                805                 810                 815     


Gln Ile Ala Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His 
            820                 825                 830         


Arg Asn Leu Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val 
        835                 840                 845             


Gln Val Ala Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys 
    850                 855                 860                 


Gln Leu Leu Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu 
865                 870                 875                 880 


Glu Ser Ile His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser 
                885                 890                 895     


Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr 
            900                 905                 910         


Ala Gly Leu Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu 
        915                 920                 925             


Arg Leu Ala Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met 
    930                 935                 940                 


Val Lys Cys Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu 
945                 950                 955                 960 


Leu Ala Asn Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu 
                965                 970                 975     


Val Ile Lys Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro 
            980                 985                 990         


His Gly Leu Thr Asn Lys Lys Leu  Glu Glu Val Glu Leu  Glu Pro Glu 
        995                 1000                 1005             


Leu Asp  Leu Asp Leu Asp Leu  Glu Ala Glu Glu Asp  Asn Leu Ala 
    1010                 1015                 1020             


Thr Thr  Thr Leu Gly Ser Ala  Leu Ser Leu Pro Val  Gly Thr Leu 
    1025                 1030                 1035             


Asn Arg  Pro Arg Gly Ser Gln  Ser Leu Leu Ser Pro  Ser Ser Gly 
    1040                 1045                 1050             


Tyr Met  Pro Met Asn Gln Gly  Asn Leu Gly Glu Ser  Cys Gln Glu 
    1055                 1060                 1065             


Ser Ala  Val Ser Gly Ser Ser  Glu Arg Cys Pro Arg  Pro Val Ser 
    1070                 1075                 1080             


Leu His  Pro Met Pro Arg Gly  Cys Leu Ala Ser Glu  Ser Ser Glu 
    1085                 1090                 1095             


Gly His  Val Thr Gly Ser Glu  Ala Glu Leu Gln Glu  Lys Val Ser 
    1100                 1105                 1110             


Met Cys  Arg Ser Arg Ser Arg  Ser Arg Ser Pro Arg  Pro Arg Gly 
    1115                 1120                 1125             


Asp Ser  Ala Tyr His Ser Gln  Arg His Ser Leu Leu  Thr Pro Val 
    1130                 1135                 1140             


Thr Pro  Leu Ser Pro Pro Gly  Leu Glu Glu Glu Asp  Val Asn Gly 
    1145                 1150                 1155             


Tyr Val  Met Pro Asp Thr His  Leu Lys Gly Thr Pro  Ser Ser Arg 
    1160                 1165                 1170             


Glu Gly  Thr Leu Ser Ser Val  Gly Leu Ser Ser Val  Leu Gly Thr 
    1175                 1180                 1185             


Glu Glu  Glu Asp Glu Asp Glu  Glu Tyr Glu Tyr Met  Asn Arg Arg 
    1190                 1195                 1200             


Arg Arg  His Ser Pro Pro His  Pro Pro Arg Pro Ser  Ser Leu Glu 
    1205                 1210                 1215             


Glu Leu  Gly Tyr Glu Tyr Met  Asp Val Gly Ser Asp  Leu Ser Ala 
    1220                 1225                 1230             


Ser Leu  Gly Ser Thr Gln Ser  Cys Pro Leu His Pro  Val Pro Ile 
    1235                 1240                 1245             


Met Pro  Thr Ala Gly Thr Thr  Pro Asp Glu Asp Tyr  Glu Tyr Met 
    1250                 1255                 1260             


Asn Arg  Gln Arg Asp Gly Gly  Gly Pro Gly Gly Asp  Tyr Ala Ala 
    1265                 1270                 1275             


Met Gly  Ala Cys Pro Ala Ser  Glu Gln Gly Tyr Glu  Glu Met Arg 
    1280                 1285                 1290             


Ala Phe  Gln Gly Pro Gly His  Gln Ala Pro His Val  His Tyr Ala 
    1295                 1300                 1305             


Arg Leu  Lys Thr Leu Arg Ser  Leu Glu Ala Thr Asp  Ser Ala Phe 
    1310                 1315                 1320             


Asp Asn  Pro Asp Tyr Trp His  Ser Arg Leu Phe Pro  Lys Ala Asn 
    1325                 1330                 1335             


Ala Gln  Arg Thr 
    1340         


<210>  49
<211>  1185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49
atgggctgcc tcgggaacag taagaccgag gaccagcgca acgaggagaa ggcgcagcgt       60

gaggccaaca aaaagatcga gaagcagctg cagaaggaca agcaggtcta ccgggccacg      120

caccgcctgc tgctgctggg tgctggagaa tctggtaaaa gcaccattgt gaagcagatg      180

aggatcctgc atgttaatgg gtttaatgga gagggcggcg aagaggaccc gcaggctgca      240

aggagcaaca gcgatggtga gaaggcaacc aaagtgcagg acatcaaaaa caacctgaaa      300

gaggcgattg aaaccattgt ggccgccatg agcaacctgg tgccccccgt ggagctggcc      360

aaccccgaga accagttcag agtggactac atcctgagtg tgatgaacgt gcctgacttt      420

gacttccctc ccgaattcta tgagcatgcc aaggctctgt gggaggatga aggagtgcgt      480

gcctgctacg aacgctccaa cgagtaccag ctgattgact gtgcccagta cttcctggac      540

aagatcgacg tgatcaagca ggctgactat gtgccgagcg atcaggacct gcttcgctgc      600

cgtgtcctga cttctggaat ctttgagacc aagttccagg tggacaaagt caacttccac      660

atgtttgacg tgggtggcca gcgcgatgaa cgccgcaagt ggatccagtg cttcaacgat      720

gtgactgcca tcatcttcgt ggtggccagc agcagctaca acatggtcat ccgggaggac      780

aaccagacca accgcctgca ggaggctctg aacctcttca agagcatctg gaacaacaga      840

tggctgcgca ccatctctgt gatcctgttc ctcaacaagc aagatctgct cgctgagaaa      900

gtccttgctg ggaaatcgaa gattgaggac tactttccag aatttgctcg ctacactact      960

cctgaggatg ctactcccga gcccggagag gacccacgcg tgacccgggc caagtacttc     1020

attcgagatg agtttctgag gatcagcact gccagtggag atgggcgtca ctactgctac     1080

cctcatttca cctgcgctgt ggacactgag aacatccgcc gtgtgttcaa cgactgccgt     1140

gacatcattc agcgcatgca ccttcgtcag tacgagctgc tctaa                     1185


<210>  50
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Met Gly Cys Leu Gly Asn Ser Lys Thr Glu Asp Gln Arg Asn Glu Glu 
1               5                   10                  15      


Lys Ala Gln Arg Glu Ala Asn Lys Lys Ile Glu Lys Gln Leu Gln Lys 
            20                  25                  30          


Asp Lys Gln Val Tyr Arg Ala Thr His Arg Leu Leu Leu Leu Gly Ala 
        35                  40                  45              


Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln Met Arg Ile Leu His 
    50                  55                  60                  


Val Asn Gly Phe Asn Gly Glu Gly Gly Glu Glu Asp Pro Gln Ala Ala 
65                  70                  75                  80  


Arg Ser Asn Ser Asp Gly Glu Lys Ala Thr Lys Val Gln Asp Ile Lys 
                85                  90                  95      


Asn Asn Leu Lys Glu Ala Ile Glu Thr Ile Val Ala Ala Met Ser Asn 
            100                 105                 110         


Leu Val Pro Pro Val Glu Leu Ala Asn Pro Glu Asn Gln Phe Arg Val 
        115                 120                 125             


Asp Tyr Ile Leu Ser Val Met Asn Val Pro Asp Phe Asp Phe Pro Pro 
    130                 135                 140                 


Glu Phe Tyr Glu His Ala Lys Ala Leu Trp Glu Asp Glu Gly Val Arg 
145                 150                 155                 160 


Ala Cys Tyr Glu Arg Ser Asn Glu Tyr Gln Leu Ile Asp Cys Ala Gln 
                165                 170                 175     


Tyr Phe Leu Asp Lys Ile Asp Val Ile Lys Gln Ala Asp Tyr Val Pro 
            180                 185                 190         


Ser Asp Gln Asp Leu Leu Arg Cys Arg Val Leu Thr Ser Gly Ile Phe 
        195                 200                 205             


Glu Thr Lys Phe Gln Val Asp Lys Val Asn Phe His Met Phe Asp Val 
    210                 215                 220                 


Gly Gly Gln Arg Asp Glu Arg Arg Lys Trp Ile Gln Cys Phe Asn Asp 
225                 230                 235                 240 


Val Thr Ala Ile Ile Phe Val Val Ala Ser Ser Ser Tyr Asn Met Val 
                245                 250                 255     


Ile Arg Glu Asp Asn Gln Thr Asn Arg Leu Gln Glu Ala Leu Asn Leu 
            260                 265                 270         


Phe Lys Ser Ile Trp Asn Asn Arg Trp Leu Arg Thr Ile Ser Val Ile 
        275                 280                 285             


Leu Phe Leu Asn Lys Gln Asp Leu Leu Ala Glu Lys Val Leu Ala Gly 
    290                 295                 300                 


Lys Ser Lys Ile Glu Asp Tyr Phe Pro Glu Phe Ala Arg Tyr Thr Thr 
305                 310                 315                 320 


Pro Glu Asp Ala Thr Pro Glu Pro Gly Glu Asp Pro Arg Val Thr Arg 
                325                 330                 335     


Ala Lys Tyr Phe Ile Arg Asp Glu Phe Leu Arg Ile Ser Thr Ala Ser 
            340                 345                 350         


Gly Asp Gly Arg His Tyr Cys Tyr Pro His Phe Thr Cys Ala Val Asp 
        355                 360                 365             


Thr Glu Asn Ile Arg Arg Val Phe Asn Asp Cys Arg Asp Ile Ile Gln 
    370                 375                 380                 


Arg Met His Leu Arg Gln Tyr Glu Leu Leu 
385                 390                 


<210>  51
<211>  1005
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51
atgaccacca tccactacaa ctacatgtgc aacagcagct gcatgggcag catgaactgg       60

cggcctatcc tgaccatcat caccctggaa gatagccggg gcagaaagcg gagaagcgtg      120

gccatgaacg agttcagcac actgcccctg cctaacctga gaatggttcg aggcacccag      180

gtgtacgacg gcaagttcgc catctttgtg cgcggcagaa agaggcggag ctacctggat      240

tctggcatcc actctggcgc tacaacaaca gccccattcc tgagcggcaa gggcaacccc      300

gaagaggaag atgtggatac cagcagaggc cggaagagaa gatccgacgt ggaaaccggc      360

aactgcatcc acacactgac aggccaccag ctgctgacct ctggcatgga actgaaggac      420

aacatcctgg tgtccggcag aggaagaaag cgcagatcta ccggcgagtg cattcacacc      480

ctgtatggcc acaccagcac cgtgcactgc atgcatctgc acgagaagag agtggtgtct      540

ggcagcagag acagaggacg caagcggaga tccgagcaag aggccctgga atactttatg      600

aagcagatca acgacgccta ccacggcggc tggactacca agatggactg gatcttccac      660

accatccgcg gacgcaagag aagaagcgtg acacaagagg ccgagcggga agagttcttc      720

gacgagacaa gacagctgtg cgacctgcgg ctgttccagc ctttcctgaa agtgatcgag      780

cgcggacgga aaagacggtc caccgagtat aagctggtgg tcgtgggagc ttgtggcgtg      840

ggaaaaagcg ccctgacaat ccagctgatc cagaaccact tcgtgcgggg aagaaaacgg      900

cggagcatgg ccatctacaa gcagagccag cacatgaccg aggtcgtgcg gcactgtcct      960

caccacgaga gatgtagcga tagcgacgga ctggcccctt gatga                     1005


<210>  52
<211>  333
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Met Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser Ser Cys Met Gly 
1               5                   10                  15      


Ser Met Asn Trp Arg Pro Ile Leu Thr Ile Ile Thr Leu Glu Asp Ser 
            20                  25                  30          


Arg Gly Arg Lys Arg Arg Ser Val Ala Met Asn Glu Phe Ser Thr Leu 
        35                  40                  45              


Pro Leu Pro Asn Leu Arg Met Val Arg Gly Thr Gln Val Tyr Asp Gly 
    50                  55                  60                  


Lys Phe Ala Ile Phe Val Arg Gly Arg Lys Arg Arg Ser Tyr Leu Asp 
65                  70                  75                  80  


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Phe Leu Ser Gly 
                85                  90                  95      


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Arg Gly Arg Lys 
            100                 105                 110         


Arg Arg Ser Asp Val Glu Thr Gly Asn Cys Ile His Thr Leu Thr Gly 
        115                 120                 125             


His Gln Leu Leu Thr Ser Gly Met Glu Leu Lys Asp Asn Ile Leu Val 
    130                 135                 140                 


Ser Gly Arg Gly Arg Lys Arg Arg Ser Thr Gly Glu Cys Ile His Thr 
145                 150                 155                 160 


Leu Tyr Gly His Thr Ser Thr Val His Cys Met His Leu His Glu Lys 
                165                 170                 175     


Arg Val Val Ser Gly Ser Arg Asp Arg Gly Arg Lys Arg Arg Ser Glu 
            180                 185                 190         


Gln Glu Ala Leu Glu Tyr Phe Met Lys Gln Ile Asn Asp Ala Tyr His 
        195                 200                 205             


Gly Gly Trp Thr Thr Lys Met Asp Trp Ile Phe His Thr Ile Arg Gly 
    210                 215                 220                 


Arg Lys Arg Arg Ser Val Thr Gln Glu Ala Glu Arg Glu Glu Phe Phe 
225                 230                 235                 240 


Asp Glu Thr Arg Gln Leu Cys Asp Leu Arg Leu Phe Gln Pro Phe Leu 
                245                 250                 255     


Lys Val Ile Glu Arg Gly Arg Lys Arg Arg Ser Thr Glu Tyr Lys Leu 
            260                 265                 270         


Val Val Val Gly Ala Cys Gly Val Gly Lys Ser Ala Leu Thr Ile Gln 
        275                 280                 285             


Leu Ile Gln Asn His Phe Val Arg Gly Arg Lys Arg Arg Ser Met Ala 
    290                 295                 300                 


Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg His Cys Pro 
305                 310                 315                 320 


His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro 
                325                 330             


<210>  53
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53
atggaagata gcagcggcaa tctgctgggc agaaacagct tcgaagtgtg cgtgtgtgcc       60

tgtcctggca gagacagaag aaccgaggaa gagaaccggg gcagaaagcg gagaagcgac      120

aaagagcagc tgaaggccat cagcaccaga gatcctctga gcaagatcac agagcaagag      180

aaggacttcc tgtggtccca ccggcactac agaggccgga agagaagatc taccggccag      240

tgtctgcacg tcctgatggg acatgtggcc gccgtgtgtt gcgtgcagta cgatggcaga      300

agagtggttt ccggcgccta cgacagagga agaaaaaggc ggtcccctat cgtgaccgtg      360

gacggctatg ttgatccctc tggcggcgat cacttctgcc tgggccagct gtctaacgtg      420

cacagaaccg aagccatcag aggacggaag cggagatccg agatcagcca catcggcagc      480

agaggcaagt acagcagcgg cttctgcaat atcgccgtga aagagaacct gatcgaactg      540

atggccgaca tcagaggtag aaagcggcgg agcaagcagg ccgattacgt gccatctgac      600

caggacctgc tgagatgcca cgtgctgacc agcggcatct tcgagacaaa gttccaggtg      660

gacaagtgat ga                                                          672


<210>  54
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Met Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
1               5                   10                  15      


Cys Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
            20                  25                  30          


Arg Gly Arg Lys Arg Arg Ser Asp Lys Glu Gln Leu Lys Ala Ile Ser 
        35                  40                  45              


Thr Arg Asp Pro Leu Ser Lys Ile Thr Glu Gln Glu Lys Asp Phe Leu 
    50                  55                  60                  


Trp Ser His Arg His Tyr Arg Gly Arg Lys Arg Arg Ser Thr Gly Gln 
65                  70                  75                  80  


Cys Leu His Val Leu Met Gly His Val Ala Ala Val Cys Cys Val Gln 
                85                  90                  95      


Tyr Asp Gly Arg Arg Val Val Ser Gly Ala Tyr Asp Arg Gly Arg Lys 
            100                 105                 110         


Arg Arg Ser Pro Ile Val Thr Val Asp Gly Tyr Val Asp Pro Ser Gly 
        115                 120                 125             


Gly Asp His Phe Cys Leu Gly Gln Leu Ser Asn Val His Arg Thr Glu 
    130                 135                 140                 


Ala Ile Arg Gly Arg Lys Arg Arg Ser Glu Ile Ser His Ile Gly Ser 
145                 150                 155                 160 


Arg Gly Lys Tyr Ser Ser Gly Phe Cys Asn Ile Ala Val Lys Glu Asn 
                165                 170                 175     


Leu Ile Glu Leu Met Ala Asp Ile Arg Gly Arg Lys Arg Arg Ser Lys 
            180                 185                 190         


Gln Ala Asp Tyr Val Pro Ser Asp Gln Asp Leu Leu Arg Cys His Val 
        195                 200                 205             


Leu Thr Ser Gly Ile Phe Glu Thr Lys Phe Gln Val Asp Lys 
    210                 215                 220         


