                         SEQUENCE LISTING

<110>  REGENXBIO INC.
 
<120>  VECTORIZED ANTI-CGRP and ANTI-CGRPR ANTIBODIES AND ADMINISTRATION
        THEREOF

<130>  38013.0017P1

<150>  63/106,854
<151>  2020-10-28

<160>  297   

<170>  PatentIn version 3.5

<210>  1
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain erenumab


<220>
<221>  misc
<222>  (236)..(241)
<223>  amino acids 236-241 can be present or absent

<220>
<221>  misc
<222>  (242)..(246)
<223>  amino acids 242-246 can be present or absent

<400>  1

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Phe Asp Gly Ser Ile Lys Tyr Ser Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Leu Asn Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Tyr 
            100                 105                 110         


Lys Tyr Tyr Gly Met Ala Val Trp Gly Gln Gly Thr Thr Val Thr Val 
        115                 120                 125             


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
    130                 135                 140                 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
                165                 170                 175     


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
            180                 185                 190         


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr 
        195                 200                 205             


Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
    210                 215                 220                 


Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly 
                245     


<210>  2
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain erenumab

<400>  2

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Thr Thr Leu Gly Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Thr Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Arg Leu 
                85                  90                  95      


Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu 
        115                 120                 125             


Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr 
    130                 135                 140                 


Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys 
145                 150                 155                 160 


Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr 
                165                 170                 175     


Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His 
            180                 185                 190         


Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys 
        195                 200                 205             


Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215     


<210>  3
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Eptinezumab


<220>
<221>  misc
<222>  (216)..(219)
<223>  amino acids 216-219 can be present or absent

<220>
<221>  misc
<222>  (220)..(225)
<223>  amino acids 220-225 can be present or absent

<220>
<221>  misc
<222>  (220)..(225)
<223>  amino acids 226-236 can be present or absent

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ile Asp Leu Ser Gly Tyr 
            20                  25                  30          


Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Gly Ile Asn Gly Ala Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Thr Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Gly Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
            100                 105                 110         


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
        115                 120                 125             


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
    130                 135                 140                 


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
145                 150                 155                 160 


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
                165                 170                 175     


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
            180                 185                 190         


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Ala Arg 
        195                 200                 205             


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
    210                 215                 220                 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Thr Leu 
225                 230                 235     


<210>  4
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Eptinezumab

<400>  4

Gln Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
1               5                   10                  15      


Arg Val Thr Ile Asn Cys Gln Ala Ser Gln Ser Val Tyr His Asn Thr 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Gln Leu 
        35                  40                  45              


Ile Tyr Asp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Val Ala Thr Tyr Tyr Cys Leu Gly Ser Tyr Asp Cys Thr 
                85                  90                  95      


Asn Gly Asp Cys Phe Val Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  5
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Fremanezumab


<220>
<221>  misc
<222>  (228)..(233)
<223>  amino acids 228-233 can be present or absent

<220>
<221>  misc
<222>  (234)..(238)
<223>  amino acids 228-233 can be present or absent

<400>  5

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Glu Ser Asp Ala Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Leu Ala Tyr Phe Asp Tyr Gly Leu Ala Ile Gln Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235             


<210>  6
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Fremanezumab

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Lys Arg Val Thr Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Leu Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser Tyr Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  7
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Galcanezumab


<220>
<221>  misc
<222>  (222)..(230)
<223>  amino acids 222 to 230 can be present or absent

<220>
<221>  misc
<222>  (231)..(241)
<223>  amino acids 231 to 241 can be present or absent

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Gly Asn Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ala Ile Tyr Glu Gly Thr Gly Lys Thr Val Tyr Ile Gln Lys Phe 
    50                  55                  60                  


Ala Asp Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Asp Tyr Val Ser Gly Phe Gly Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu 
    


<210>  8
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Galcanezumab

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Gly Tyr His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Asp Ala Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  9
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Erenumab

<400>  9
caggtgcagc tggtggagag cggcggcggc gtggtgcagc ccggcagaag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc agcttcggca tgcactgggt gagacaggcc      120

cccggcaagg gcctggagtg ggtggccgtg atcagcttcg acggcagcat caagtacagc      180

gtggacagcg tgaagggcag attcaccatc agcagagaca acagcaagaa caccctgttc      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgcgc cagagacaga      300

ctgaactact acgacagcag cggctactac cactacaagt actacggcat ggccgtgtgg      360

ggccagggca ccaccgtgac cgtgagcagc gccagcacca agggccccag cgtgttcccc      420

ctggccccct gcagcagaag caccagcgag agcaccgccg ccctgggctg cctggtgaag      480

gactacttcc ccgagcccgt gaccgtgagc tggaacagcg gcgccctgac cagcggcgtg      540

cacaccttcc ccgccgtgct gcagagcagc ggcctgtaca gcctgagcag cgtggtgacc      600

gtgcccagca gcaacttcgg cacccagacc tacacctgca acgtggacca caagcccagc      660

aacaccaagg tggacaagac cgtggagaga aagtgctgcg tggagtgccc cccctgcccc      720

gccccccccg tggccggc                                                    738


<210>  10
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Erenumab

<400>  10
cagagcgtgc tgacccagcc ccccagcgtg agcgccgccc ccggccagaa ggtgaccatc       60

agctgcagcg gcagcagcag caacatcggc aacaactacg tgagctggta ccagcagctg      120

cccggcaccg cccccaagct gctgatctac gacaacaaca agagacccag cggcatcccc      180

gacagattca gcggcagcaa gagcggcacc agcaccaccc tgggcatcac cggcctgcag      240

accggcgacg aggccgacta ctactgcggc acctgggaca gcagactgag cgccgtggtg      300

ttcggcggcg gcaccaagct gaccgtgctg ggccagccca aggccaaccc caccgtgacc      360

ctgttccccc ccagcagcga ggagctgcag gccaacaagg ccaccctggt gtgcctgatc      420

agcgacttct accccggcgc cgtgaccgtg gcctggaagg ccgacggcag ccccgtgaag      480

gccggcgtgg agaccaccaa gcccagcaag cagagcaaca acaagtacgc cgccagcagc      540

tacctgagcc tgacccccga gcagtggaag agccacagaa gctacagctg ccaggtgacc      600

cacgagggca gcaccgtgga gaagaccgtg gcccccaccg agtgcagc                   648


<210>  11
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Eptinezumab


<220>
<221>  misc
<222>  (646)..(657)
<223>  nucleotides 646-657 can be present or absent

<220>
<221>  misc
<222>  (658)..(675)
<223>  nucleotides 658-675 can be present or absent

<220>
<221>  misc
<222>  (676)..(708)
<223>  nucleotides 676-708 can be present or absent

<400>  11
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg tgagcggcat cgacctgagc ggctactaca tgaactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgggcgtg atcggcatca acggcgccac ctactacgcc      180

agctgggcca agggcaggtt caccatcagc agggacaaca gcaagaccac cgtgtacctg      240

cagatgaaca gcctgagggc cgaggacacc gccgtgtact tctgcgccag gggcgacatc      300

tggggccagg gcaccctggt gaccgtgagc agcgccagca ccaagggccc cagcgtgttc      360

cccctggccc ccagcagcaa gagcaccagc ggcggcaccg ccgccctggg ctgcctggtg      420

aaggactact tccccgagcc cgtgaccgtg agctggaaca gcggcgccct gaccagcggc      480

gtgcacacct tccccgccgt gctgcagagc agcggcctgt acagcctgag cagcgtggtg      540

accgtgccca gcagcagcct gggcacccag acctacatct gcaacgtgaa ccacaagccc      600

agcaacacca aggtggacgc cagggtggag cccaagagct gcgacaagac ccacacctgc      660

cccccctgcc ccgcccccga gctgctgggc ggccccagcg tgaccctg                   708


<210>  12
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Eptinezumab

<400>  12
caggtgctga cccagagccc cagcagcctg agcgccagcg tgggcgacag ggtgaccatc       60

aactgccagg ccagccagag cgtgtaccac aacacctacc tggcctggta ccagcagaag      120

cccggcaagg tgcccaagca gctgatctac gacgccagca ccctggccag cggcgtgccc      180

agcaggttca gcggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctgcag      240

cccgaggacg tggccaccta ctactgcctg ggcagctacg actgcaccaa cggcgactgc      300

ttcgtgttcg gcggcggcac caaggtggag atcaagagga ccgtggccgc ccccagcgtg      360

ttcatcttcc cccccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag ggaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagggg cgagtgc         657


<210>  13
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Fremanezumab


<220>
<221>  misc
<222>  (682)..(699)
<223>  nucleotides 682-699 can be present or absent

<220>
<221>  misc
<222>  (700)..(714)
<223>  nucleotides 700-714 can be present or absent

<400>  13
gaggtgcagc tggtggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

agctgcgccg ccagcggctt caccttcagc aactactgga tcagctgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtggccgag atcaggagcg agagcgacgc cagcgccacc      180

cactacgccg aggccgtgaa gggcaggttc accatcagca gggacaacgc caagaacagc      240

ctgtacctgc agatgaacag cctgagggcc gaggacaccg ccgtgtacta ctgcctggcc      300

tacttcgact acggcctggc catccagaac tactggggcc agggcaccct ggtgaccgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg ccccctgcag caggagcacc      420

agcgagagca ccgccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgagctgga acagcggcgc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcaa cttcggcacc      600

cagacctaca cctgcaacgt ggaccacaag cccagcaaca ccaaggtgga caagaccgtg      660

gagaggaagt gctgcgtgga gtgccccccc tgccccgccc cccccgtggc cggc            714


<210>  14
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; light chain Fremanezumab

<400>  14
gagatcgtgc tgacccagag ccccgccacc ctgagcctga gccccggcga gagggccacc       60

ctgagctgca aggccagcaa gagggtgacc acctacgtga gctggtacca gcagaagccc      120

ggccaggccc ccaggctgct gatctacggc gccagcaaca ggtacctggg catccccgcc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccgtgtacta ctgcagccag agctacaact acccctacac cttcggccag      300

ggcaccaagc tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  15
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Galcanezumab


<220>
<221>  misc
<222>  (664)..(690)
<223>  nucleotides 664-690 can be present or absent

<220>
<221>  misc
<222>  (691)..(723)
<223>  nucleotides 691-723 can be present or absent

<400>  15
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcagcag cgtgaaggtg       60

agctgcaagg ccagcggcta caccttcggc aactactgga tgcagtgggt gaggcaggcc      120

cccggccagg gcctggagtg gatgggcgcc atctacgagg gcaccggcaa gaccgtgtac      180

atccagaagt tcgccgacag ggtgaccatc accgccgaca agagcaccag caccgcctac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt actactgcgc caggctgagc      300

gactacgtga gcggcttcgg ctactggggc cagggcacca ccgtgaccgt gagcagcgcc      360

agcaccaagg gccccagcgt gttccccctg gccccctgca gcaggagcac cagcgagagc      420

accgccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgagctgg      480

aacagcggcg ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac caagacctac      600

acctgcaacg tggaccacaa gcccagcaac accaaggtgg acaagagggt ggagagcaag      660

tacggccccc cctgcccccc ctgccccgcc cccgaggccg ccggcggccc cagcgtgttc      720

ctg                                                                    723


<210>  16
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; heavy chain Galcanezumab

<400>  16
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagggtgacc       60

atcacctgca gggccagcaa ggacatcagc aagtacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctactac accagcggct accacagcgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag ggcgacgccc tgccccccac cttcggcggc      300

ggcaccaagg tggagatcaa gaggaccgtg gccgccccca gcgtgttcat cttccccccc      360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gcctgctgaa caacttctac      420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac agcacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc      600

ctgagcagcc ccgtgaccaa gagcttcaac aggggcgagt gc                         642


<210>  17
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; antibody fragment


<220>
<221>  misc
<222>  (1)..(4)
<223>  Xaa can be any amino acid

<400>  17

Xaa Xaa Xaa Xaa 
1               


<210>  18
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IgG1 Fc domain

<400>  18

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  19
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IgG2 Fc domain

<400>  19

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  20
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IgG4 Fc domain

<400>  20

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210>  21
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Erenumab fragment

<400>  21

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  22
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Eptinezumab fragment

<400>  22

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  23
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Fremanezumab fragment

<400>  23

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        195                 200                 205 


<210>  24
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; Galcanezumab fragment

<400>  24

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
1               5                   10                  15      


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            20                  25                  30          


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        35                  40                  45              


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    50                  55                  60                  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
65                  70                  75                  80  


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                85                  90                  95      


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            100                 105                 110         


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        115                 120                 125             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    130                 135                 140                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
145                 150                 155                 160 


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                165                 170                 175     


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            180                 185                 190         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        195                 200                 205 


<210>  25
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  25
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg gtcgaggtga gccccacgtt ctgcttcact ctccccatct      420

cccccccctc cccaccccca attttgtatt tatttatttt ttaattattt tgtgcagcga      480

tgggggcggg gggggggggg gggcgcgcgc caggcggggc ggggcggggc gaggggcggg      540

gcggggcgag gcggagaggt gcggcggcag ccaatcagag cggcgcgctc cgaaagtttc      600

cttttatggc gaggcggcgg cggcggcggc cctataaaaa gcgaagcgcg cggcgggcgg      660

gagtcgctgc gcgctgcctt cgccccgtgc cccgctccgc cgccgcctcg cgccgcccgc      720

cccggctctg actgaccgcg ttactcccac aggtgagcgg gcgggacggc ccttctcctc      780

cgggctgtaa ttagcgcttg gtttaatgac ggcttgtttc ttttctgtgg ctgcgtgaaa      840

gccttgaggg gctccgggag ggccctttgt gcggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gctccgcgct gcccggcggc tgtgagcgct      960

gcgggcgcgg cgcggggctt tgtgcgctcc gcagtgtgcg cgaggggagc gcggccgggg     1020

gcggtgcccc gcggtgcggg gggggctgcg aggggaacaa aggctgcgtg cggggtgtgt     1080

gcgtgggggg gtgagcaggg ggtgtgggcg cgtcggtcgg gctgcaaccc cccctgcacc     1140

cccctccccg agttgctgag cacggcccgg cttcgggtgc ggggctccgt acggggcgtg     1200

gcgcggggct cgccgtgccg ggcggggggt ggcggcaggt gggggtgccg ggcggggcgg     1260

ggccgcctcg ggccggggag ggctcggggg aggggcgcgg cggcccccgg agcgccggcg     1320

gctgtcgagg cgcggcgagc cgcagccatt gccttttatg gtaatcgtgc gagagggcgc     1380

agggacttcc tttgtcccaa atctgtgcgg agccgaaatc tgggaggcgc cgccgcaccc     1440

cctctagcgg gcgcggggcg aagcggtgcg gcgccggcag gaaggaaatg ggcggggagg     1500

gccttcgtgc gtcgccgcgc cgccgtcccc ttctccctct ccagcctcgg ggctgtccgc     1560

ggggggacgg ctgccttcgg gggggacggg gcagggcggg gttcggcttc tggcgtgtga     1620

ccggcggctc tagagcctct gctaaccatg ttcatgcctt cttctttttc ctacagctcc     1680

tgggcaacgt gctggttatt gtgctgtctc atcattttgg caaag                     1725


<210>  26
<211>  251
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  26
atggaggcgg tactatgtag atgagaattc aggagcaaac tgggaaaagc aactgcttcc       60

aaatatttgt gatttttaca gtgtagtttt ggaaaaactc ttagcctacc aattcttcta      120

agtgttttaa aatgtgggag ccagtacaca tgaagttata gagtgtttta atgaggctta      180

aatatttacc gtaactatga aatgctacgc atatcatgct gttcaggctc cgtggccacg      240

caactcatac t                                                           251


<210>  27
<211>  212
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  27
gggcagagcg cacatcgccc acagtccccg agaagttggg gggaggggtc ggcaattgaa       60

cgggtgccta gagaaggtgg cgcggggtaa actgggaaag tgatgtcgtg tactggctcc      120

gcctttttcc cgagggtggg ggagaaccgt atataagtgc agtagtcgcc gtgaacgttc      180

tttttcgcaa cgggtttgcc gccagaacac ag                                    212


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  28

Met Tyr Arg Met Gln Leu Leu Leu Leu Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  29
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  29
atgtatagga tgcaactgct cctcctgatt gctctgagcc tggctcttgt gaccaactct       60


<210>  30
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  30

Met Asn Phe Leu Leu Ser Trp Val His Trp Ser Leu Ala Leu Leu Leu 
1               5                   10                  15      


Tyr Leu His His Ala Lys Trp Ser Gln Ala 
            20                  25      


<210>  31
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  31

Met Glu Arg Ala Ala Pro Ser Arg Arg Val Pro Leu Pro Leu Leu Leu 
1               5                   10                  15      


Leu Gly Gly Leu Ala Leu Leu Ala Ala Gly Val Asp Ala 
            20                  25                  


<210>  32
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  32

Met Ala Pro Leu Arg Pro Leu Leu Ile Leu Ala Leu Leu Ala Trp Val 
1               5                   10                  15      


Ala Leu Ala 
            


<210>  33
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  33

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala 
        


<210>  34
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  34

Met Arg Leu Leu Ala Phe Leu Ser Leu Leu Ala Leu Val Leu Gln Glu 
1               5                   10                  15      


Thr Gly Thr 
            


<210>  35
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  35

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  36
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  36

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  37
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  37

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  38
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  38

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  39

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  40
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  40

Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      


Cys Leu Val Pro Val Ser Leu Ala 
            20                  


<210>  41
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  41

Met Lys Ala Ala Val Leu Thr Leu Ala Val Leu Phe Leu Thr Gly Ser 
1               5                   10                  15      


Gln Ala 
        


<210>  42
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  42

Met Lys Leu Leu Ala Ala Thr Val Leu Leu Leu Thr Ile Cys Ser Leu 
1               5                   10                  15      


Glu Gly 
        


<210>  43
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  43

Met Asp Pro Pro Arg Pro Ala Leu Leu Ala Leu Leu Ala Leu Pro Ala 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Gly Ala Arg Ala 
            20                  25          


<210>  44
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  44

Met Gln Arg Val Asn Met Ile Met Ala Glu Ser Pro Gly Leu Ile Thr 
1               5                   10                  15      


Ile Cys Leu Leu Gly Tyr Leu Leu Ser Ala Glu Cys 
            20                  25              


<210>  45
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  45

Met Gly Pro Leu Met Val Leu Phe Cys Leu Leu Phe Leu Tyr Pro Gly 
1               5                   10                  15      


Leu Ala Asp Ser 
            20  


<210>  46
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  46

Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val 
1               5                   10                  15      


Gly Gly 
        


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  47

Met Leu Leu Leu Phe Ser Val Ile Leu Ile Ser Trp Val Ser Thr Val 
1               5                   10                  15      


Gly Gly 
        


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  48

Met Phe Ser Met Arg Ile Val Cys Leu Val Leu Ser Val Val Gly Thr 
1               5                   10                  15      


Ala Trp Thr 
            


<210>  49
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  49

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser 
            20                  25                  30  


<210>  50
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  50

Met Ser Trp Ser Leu His Pro Arg Asn Leu Ile Leu Tyr Phe Tyr Ala 
1               5                   10                  15      


Leu Leu Phe Leu Ser Ser Thr Cys Val Ala 
            20                  25      


<210>  51
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  51

Met Lys Ser Leu Val Leu Leu Leu Cys Leu Ala Gln Leu Trp Gly Cys 
1               5                   10                  15      


His Ser 
        


<210>  52
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  52

Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu 
1               5                   10                  15      


Cys Trp Ser Leu Ala Ile Ala 
            20              


<210>  53
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  53

Met Lys Leu Ile Thr Ile Leu Phe Leu Cys Ser Arg Leu Leu Leu Ser 
1               5                   10                  15      


Leu Thr 
        


<210>  54
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  54

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser 
            20  


<210>  55
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  55

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly 
            


<210>  56
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  56

Met Ala His Val Arg Gly Leu Gln Leu Pro Gly Cys Leu Ala Leu Ala 
1               5                   10                  15      


Ala Leu Cys Ser Leu Val His Ser 
            20                  


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  57

Met Ile Ser Arg Met Glu Lys Met Thr Met Met Met Lys Ile Leu Ile 
1               5                   10                  15      


Met Phe Ala Leu Gly Met Asn Tyr Trp Ser Cys Ser Gly 
            20                  25                  


<210>  58
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  58

Met Tyr Ser Asn Val Ile Gly Thr Val Thr Ser Gly Lys Arg Lys Val 
1               5                   10                  15      


Tyr Leu Leu Ser Leu Leu Leu Ile Gly Phe Trp Asp Cys Val Thr Cys 
            20                  25                  30          


<210>  59
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  59

Met Arg Leu Ala Val Gly Ala Leu Leu Val Cys Ala Val Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  60

Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  61
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  61

Met Phe Ser Phe Val Asp Leu Arg Leu Leu Leu Leu Leu Ala Ala Thr 
1               5                   10                  15      


Ala Leu Leu Thr His Gly 
            20          


<210>  62
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  62

Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu 
1               5                   10                  15      


Cys Leu Ala 
            


<210>  63
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  63

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly 
            20          


<210>  64
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  64

Met Ser Leu Ser Ala Phe Thr Leu Phe Leu Ala Leu Ile Gly Gly Thr 
1               5                   10                  15      


Ser Gly 
        


<210>  65
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  65

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala 
            20                  25          


<210>  66
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  66

Met Trp Ala Thr Leu Pro Leu Leu Cys Ala Gly Ala Trp Leu Leu Gly 
1               5                   10                  15      


Val Pro Val Cys Gly Ala 
            20          


<210>  67
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  67

Met Gln Ala Leu Val Leu Leu Leu Cys Ile Gly Ala Leu Leu Gly His 
1               5                   10                  15      


Ser Ser Cys 
            


<210>  68
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  68

Met Gln Met Ser Pro Ala Leu Thr Cys Leu Val Leu Gly Leu Ala Leu 
1               5                   10                  15      


Val Phe Gly Glu Gly Ser Ala 
            20              


<210>  69
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  69

Met Gln Pro Ser Ser Leu Leu Pro Leu Ala Leu Cys Leu Leu Ala Ala 
1               5                   10                  15      


Pro Ala Ser Ala 
            20  


<210>  70
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  70

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala 
            20              


<210>  71
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  71

Met Leu Arg Gly Pro Gly Pro Gly Leu Leu Leu Leu Ala Val Gln Cys 
1               5                   10                  15      


Leu Gly Thr Ala Val Pro Ser Thr Gly Ala Ser Lys Ser Lys Arg 
            20                  25                  30      


<210>  72
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  72

Gly Ser Gly 
1           


<210>  73
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  73

Arg Lys Arg Arg 
1               


<210>  74
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  74

Arg Arg Arg Arg 
1               


<210>  75
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  75

Arg Arg Lys Arg 
1               


<210>  76
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  76

Arg Lys Lys Arg 
1               


<210>  77
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  77

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  78
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  78

Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210>  79
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  79

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  80
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  80

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  81
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  81

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  82
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  82

Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210>  83
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  83

Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly 
1               5                   10                  15      


Asp Val Glu Ser Asn Pro Gly Pro 
            20                  


<210>  84
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  84

Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys 
1               5                   10                  15      


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25          


<210>  85
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  85

Arg Lys Arg Arg Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  86
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  86

Arg Lys Arg Arg Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys 
1               5                   10                  15      


Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25  


<210>  87
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  87

Arg Lys Arg Arg Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu 
1               5                   10                  15      


Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25              


<210>  88
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  88

Arg Lys Arg Arg Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe 
1               5                   10                  15      


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
            20                  25                  30      


<210>  89
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  89
agaaagagaa gaggctctgg agaaggcaga ggctccctgc tgacatgtgg ggatgttgaa       60

gagaatcctg ggcct                                                        75


<210>  90
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  90
agaaagagaa ga                                                           12


<210>  91
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  91
agaaagagaa gaggctctgg a                                                 21


<210>  92
<211>  9
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  92
ggctctgga                                                                9


<210>  93
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker

<400>  93
gaaggcagag gctccctgct gacatgtggg gatgttgaag agaatcctgg gcct             54


<210>  94
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  94

Cys Pro Pro Cys Pro Ala 
1               5       


<210>  95
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  95

Cys Pro Pro Cys Pro 
1               5   


<210>  96
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  96

Cys Pro Pro Cys Ala 
1               5   


<210>  97
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  97

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  98
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  98

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  99

Glu Pro Lys Ser Cys Asp Lys Thr His Leu 
1               5                   10  


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  100

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  101
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  101

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  102
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  102

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


<210>  103
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  103

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  104
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  104

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  105
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  105

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly 
            20          


<210>  106
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  106

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  107
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  107

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  108
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  108

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  109

Glu Arg Lys Ser Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  110
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  110

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly 
            


<210>  111
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  111

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  112
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  112

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala 
1               5                   10              


<210>  113
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  113

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  114
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  114

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu 
            20                  


<210>  115
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  115

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly 
        


<210>  116
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  116

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
1               5                   10              


<210>  117
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  117

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala 
            20          


<210>  118
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  118

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  119
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  119

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu 
            20                  25          


<210>  120
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  120

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly 
            20          


<210>  121
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  121

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  122
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge region

<400>  122

Glu Pro Lys Ser Cys Asp Lys Thr His Leu Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu 
            20                  25          


<210>  123
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  123

Met Trp Cys Ile Val Leu Phe Ser Leu Leu Ala Trp Val Tyr Ala 
1               5                   10                  15  


<210>  124
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  124

Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser 
1               5                   10                  15      


Ala 
    


<210>  125
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  125

Met Trp Gln Leu Trp Ala Ser Leu Cys Cys Leu Leu Val Leu Ala Asn 
1               5                   10                  15      


Ala 
    


<210>  126
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  126

Met Leu Leu Ile Leu Leu Ser Val Ala Leu Leu Ala Phe Ser Ser Ala 
1               5                   10                  15      


<210>  127
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; signal peptide

<400>  127

Met Trp Lys Arg Trp Leu Ala Leu Ala Leu Ala Leu Val Ala Val Ala 
1               5                   10                  15      


Trp Val Arg Ala 
            20  


<210>  128
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  128

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Glu Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Phe Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Ala Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys Asn Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  129
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  129

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  130
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  130

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  131
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  131

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Gly 
    130                 135                 140                 


Ala Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Arg Gly Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Gly Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  132
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  132

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Val Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Arg Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Asp Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Val Gly 
145                 150                 155                 160 


Lys Ser Gly Lys Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Asn Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Lys Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Gly Thr Thr Ser Gly Thr Thr Asn Gln Ser Arg Leu Leu Phe Ser 
    450                 455                 460                 


Gln Ala Gly Pro Gln Ser Met Ser Leu Gln Ala Arg Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Thr Ala Asn Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Pro Trp Thr Ala Ala Ser Lys Tyr His Leu Asn 
            500                 505                 510         


Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Glu Lys Phe Phe Pro Met His Gly Asn Leu Ile Phe Gly 
    530                 535                 540                 


Lys Glu Gly Thr Thr Ala Ser Asn Ala Glu Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln 
                565                 570                 575     


Tyr Gly Thr Val Ala Asn Asn Leu Gln Ser Ser Asn Thr Ala Pro Thr 
            580                 585                 590         


Thr Arg Thr Val Asn Asp Gln Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Thr Thr Phe Ser Pro Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  133
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  133

Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210>  134
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  134

Met Thr Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser Glu 
1               5                   10                  15      


Gly Val Arg Glu Trp Trp Ala Leu Gln Pro Gly Ala Pro Lys Pro Lys 
            20                  25                  30          


Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro Val 
    50                  55                  60                  


Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp Gln 
65                  70                  75                  80  


Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Gln Arg Leu Gln Gly Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Leu 
        115                 120                 125             


Gly Leu Val Glu Gln Ala Gly Glu Thr Ala Pro Gly Lys Lys Arg Pro 
    130                 135                 140                 


Leu Ile Glu Ser Pro Gln Gln Pro Asp Ser Ser Thr Gly Ile Gly Lys 
145                 150                 155                 160 


Lys Gly Lys Gln Pro Ala Lys Lys Lys Leu Val Phe Glu Asp Glu Thr 
                165                 170                 175     


Gly Ala Gly Asp Gly Pro Pro Glu Gly Ser Thr Ser Gly Ala Met Ser 
            180                 185                 190         


Asp Asp Ser Glu Met Arg Ala Ala Ala Gly Gly Ala Ala Val Glu Gly 
        195                 200                 205             


Gly Gln Gly Ala Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys 
    210                 215                 220                 


Asp Ser Thr Trp Ser Glu Gly His Val Thr Thr Thr Ser Thr Arg Thr 
225                 230                 235                 240 


Trp Val Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Arg Leu Gly Glu 
                245                 250                 255     


Ser Leu Gln Ser Asn Thr Tyr Asn Gly Phe Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Asn Trp Gly Met Arg Pro Lys Ala Met Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Thr Ser Asn Gly Glu 
305                 310                 315                 320 


Thr Thr Val Ala Asn Asn Leu Thr Ser Thr Val Gln Ile Phe Ala Asp 
                325                 330                 335     


Ser Ser Tyr Glu Leu Pro Tyr Val Met Asp Ala Gly Gln Glu Gly Ser 
            340                 345                 350         


Leu Pro Pro Phe Pro Asn Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Cys Gly Leu Val Thr Gly Asn Thr Ser Gln Gln Gln Thr Asp Arg Asn 
    370                 375                 380                 


Ala Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
385                 390                 395                 400 


Asn Asn Phe Glu Ile Thr Tyr Ser Phe Glu Lys Val Pro Phe His Ser 
                405                 410                 415     


Met Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
            420                 425                 430         


Asp Gln Tyr Leu Trp Gly Leu Gln Ser Thr Thr Thr Gly Thr Thr Leu 
        435                 440                 445             


Asn Ala Gly Thr Ala Thr Thr Asn Phe Thr Lys Leu Arg Pro Thr Asn 
    450                 455                 460                 


Phe Ser Asn Phe Lys Lys Asn Trp Leu Pro Gly Pro Ser Ile Lys Gln 
465                 470                 475                 480 


Gln Gly Phe Ser Lys Thr Ala Asn Gln Asn Tyr Lys Ile Pro Ala Thr 
                485                 490                 495     


Gly Ser Asp Ser Leu Ile Lys Tyr Glu Thr His Ser Thr Leu Asp Gly 
            500                 505                 510         


Arg Trp Ser Ala Leu Thr Pro Gly Pro Pro Met Ala Thr Ala Gly Pro 
        515                 520                 525             


Ala Asp Ser Lys Phe Ser Asn Ser Gln Leu Ile Phe Ala Gly Pro Lys 
    530                 535                 540                 


Gln Asn Gly Asn Thr Ala Thr Val Pro Gly Thr Leu Ile Phe Thr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly 
                565                 570                 575     


Asn Leu Pro Gly Gly Asp Gln Ser Asn Ser Asn Leu Pro Thr Val Asp 
            580                 585                 590         


Arg Leu Thr Ala Leu Gly Ala Val Pro Gly Met Val Trp Gln Asn Arg 
        595                 600                 605             


Asp Ile Tyr Tyr Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Ile Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Phe Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Ala Thr Thr Phe Ser Ser Thr Pro Val Asn Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Gln Ile Asp Trp Glu Ile Gln Lys Glu 
        675                 680                 685             


Arg Ser Lys Arg Trp Asn Pro Glu Val Gln Phe Thr Ser Asn Tyr Gly 
    690                 695                 700                 


Gln Gln Asn Ser Leu Leu Trp Ala Pro Asp Ala Ala Gly Lys Tyr Thr 
705                 710                 715                 720 


Glu Pro Arg Ala Ile Gly Thr Arg Tyr Leu Thr His His Leu 
                725                 730                 


<210>  135
<211>  724
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  135

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  136
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  136

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Lys Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Ser Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Ser Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  137
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  137

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Ala Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Val Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn 
    210                 215                 220                 


Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Ser Glu Thr Ala Gly Ser Thr Asn Asp Asn 
            260                 265                 270         


Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Lys Leu Arg Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Ile Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn 
    370                 375                 380                 


Gly Ser Gln Ser Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr Ser 
                405                 410                 415     


Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ala 
        435                 440                 445             


Arg Thr Gln Ser Asn Pro Gly Gly Thr Ala Gly Asn Arg Glu Leu Gln 
    450                 455                 460                 


Phe Tyr Gln Gly Gly Pro Ser Thr Met Ala Glu Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Phe Arg Gln Gln Arg Val Ser Lys Thr Leu Asp 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Val Leu Ile 
    530                 535                 540                 


Phe Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Leu Glu Asn Val Leu 
545                 550                 555                 560 


Met Thr Asn Glu Glu Glu Ile Arg Pro Thr Asn Pro Val Ala Thr Glu 
                565                 570                 575     


Glu Tyr Gly Ile Val Ser Ser Asn Leu Gln Ala Ala Asn Thr Ala Ala 
            580                 585                 590         


Gln Thr Gln Val Val Asn Asn Gln Gly Ala Leu Pro Gly Met Val Trp 
        595                 600                 605             


Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro 
    610                 615                 620                 


His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly 
625                 630                 635                 640 


Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro 
                645                 650                 655     


Ala Asn Pro Pro Glu Val Phe Thr Pro Ala Lys Phe Ala Ser Phe Ile 
            660                 665                 670         


Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu 
        675                 680                 685             


Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser 
    690                 695                 700                 


Asn Phe Glu Lys Gln Thr Gly Val Asp Phe Ala Val Asp Ser Gln Gly 
705                 710                 715                 720 


Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn 
                725                 730                 735     


Leu 
    


<210>  138
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  138

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  139
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  139

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  140
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  140

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Asp Gly Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  141
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  141

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Asp 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  142
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  142

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Thr Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Gln Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  143
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  143

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  144
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  144

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Arg Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  145
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  145

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Thr Lys Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  146
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  146

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asn Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Ser Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Asn Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Ala Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  147
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  147

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Gln Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly His Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Pro Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Ser Asn Ser Gly Thr Leu Gln Gln Ser Arg Leu Leu Phe Ser Gln 
    450                 455                 460                 


Ala Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn 
                485                 490                 495     


Asn Ser Asn Phe Pro Trp Thr Ala Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Thr Asn Ala Asn Asp Ala Asp Leu Glu His Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Asn Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Gly Pro Thr Thr 
            580                 585                 590         


Glu Asn Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  148
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  148

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Arg Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  149
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  149

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Ile Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Ser Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Met Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ala Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Asp Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Tyr Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Asp Ser Gly Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Ser Gly Asn Thr Gln Ala Ala Thr 
            580                 585                 590         


Ser Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  150
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  150

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  151
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  151

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Gly Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Gly Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Thr Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asn Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  152
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  152

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Ala Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Arg Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Thr Ser Leu Gly Ser Thr Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg Thr 
        435                 440                 445             


Gln Thr Ala Ser Gly Thr Gln Gln Ser Arg Leu Leu Phe Ser Gln Ala 
    450                 455                 460                 


Gly Pro Thr Ser Met Ser Leu Gln Ala Lys Asn Trp Leu Pro Gly Pro 
465                 470                 475                 480 


Cys Tyr Arg Gln Gln Arg Leu Ser Lys Gln Ala Asn Asp Asn Asn Asn 
                485                 490                 495     


Ser Asn Phe Pro Trp Thr Gly Ala Thr Lys Tyr Tyr Leu Asn Gly Arg 
            500                 505                 510         


Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp Asp 
        515                 520                 525             


Glu Glu Lys Phe Phe Pro Met His Gly Thr Leu Ile Phe Gly Lys Glu 
    530                 535                 540                 


Gly Thr Asn Ala Thr Asn Ala Glu Leu Glu Asn Val Met Ile Thr Asp 
545                 550                 555                 560 


Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr Gly 
                565                 570                 575     


Tyr Val Ser Asn Asn Leu Gln Asn Ser Asn Thr Ala Ala Ser Thr Glu 
            580                 585                 590         


Thr Val Asn His Gln Gly Ala Leu Pro Gly Met Val Trp Gln Asp Arg 
        595                 600                 605             


Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp 
    610                 615                 620                 


Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His 
625                 630                 635                 640 


Pro Pro Pro Gln Ile Met Ile Lys Asn Thr Pro Val Pro Ala Asn Pro 
                645                 650                 655     


Pro Thr Asn Phe Ser Ser Ala Lys Phe Ala Ser Phe Ile Thr Gln Tyr 
            660                 665                 670         


Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu 
        675                 680                 685             


Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Asn 
    690                 695                 700                 


Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr Ser 
705                 710                 715                 720 


Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 


<210>  153
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; HIF1alpha binding site

<400>  153

Arg Cys Gly Thr Gly 
1               5   


<210>  154
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  154
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

tctagaaggc tcagaggcac acaggagttt ctgggctcac cctgccccct tccaacccct      300

cagttcccat cctccagcag ctgtttgtgt gctgcctctg aagtccacac tgaacaaact      360

tcagcctact catgtcccta aaatgggcaa acattgcaag cagcaaacag caaacacaca      420

gccctccctg cctgctgacc ttggagctgg ggcagaggtc agagacctct ctgggcccat      480

gccacctcca acatccactc gaccccttgg aatttcggtg gagaggagca gaggttgtcc      540

tggcgtggtt taggtagtgt gagaggggta cccggggatc ttgctaccag tggaacagcc      600

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      660

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      720

atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      780

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      840

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac      900

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc      960

tgggacagt                                                              969


<210>  155
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  155
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctgggccca tgccacctcc aacatccact cgaccccttg gaatttcggt      600

ggagaggagc agaggttgtc ctggcgtggt ttaggtagtg tgagaggggt acccggggat      660

cttgctacca gtggaacagc cactaaggat tctgcagtga gagcagaggg ccagctaagt      720

ggtactctcc cagagactgt ctgactcacg ccaccccctc caccttggac acaggacgct      780

gtggtttctg agccaggtac aatgactcct ttcggtaagt gcagtggaag ctgtacactg      840

cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag atcccagcca gtggacttag      900

cccctgtttg ctcctccgat aactggggtg accttggtta atattcacca gcagcctccc      960

ccgttgcccc tctggatcca ctgcttaaat acggacgagg acagggccct gtctcctcag     1020

cttcaggcac caccactgac ctgggacagt                                      1050


<210>  156
<211>  1089
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  156
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagt                                                             1089


<210>  157
<211>  1430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  157
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagcc cttaagctag caggttaatt tttaaaaagc      360

agtcaaaagt ccaagtggcc cttggcagca tttactctct ctgtttgctc tggttaataa      420

tctcaggagc acaaacattc cagatccagg ttaattttta aaaagcagtc aaaagtccaa      480

gtggcccttg gcagcattta ctctctctgt ttgctctggt taataatctc aggagcacaa      540

acattccaga tccggcgcgc cagggctgga agctaccttt gacatcattt cctctgcgaa      600

tgcatgtata atttctacag aacctattag aaaggatcac ccagcctctg cttttgtaca      660

actttccctt aaaaaactgc caattccact gctgtttggc ccaatagtga gaactttttc      720

ctgctgcctc ttggtgcttt tgcctatggc ccctattctg cctgctgaag acactcttgc      780

cagcatggac ttaaacccct ccagctctga caatcctctt tctcttttgt tttacatgaa      840

gggtctggca gccaaagcaa tcactcaaag ttcaaacctt atcatttttt gctttgttcc      900

tcttggcctt ggttttgtac atcagctttg aaaataccat cccagggtta atgctggggt      960

taatttataa ctaagagtgc tctagttttg caatacagga catgctataa aaatggaaag     1020

atgttgcttt ctgagaggat cttgctacca gtggaacagc cactaaggat tctgcagtga     1080

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1140

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1200

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1260

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1320

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1380

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1430


<210>  158
<211>  1318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  158
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc agatccaggt taatttttaa      120

aaagcagtca aaagtccaag tggcccttgg cagcatttac tctctctgtt tgctctggtt      180

aataatctca ggagcacaaa cattccagat ccggcgcgcc agggctggaa gctacctttg      240

acatcatttc ctctgcgaat gcatgtataa tttctacaga acctattaga aaggatcacc      300

cagcctctgc ttttgtacaa ctttccctta aaaaactgcc aattccactg ctgtttggcc      360

caatagtgag aactttttcc tgctgcctct tggtgctttt gcctatggcc cctattctgc      420

ctgctgaaga cactcttgcc agcatggact taaacccctc cagctctgac aatcctcttt      480

ctcttttgtt ttacatgaag ggtctggcag ccaaagcaat cactcaaagt tcaaacctta      540

tcattttttg ctttgttcct cttggccttg gttttgtaca tcagctttga aaataccatc      600

ccagggttaa tgctggggtt aatttataac taagagtgct ctagttttgc aatacaggac      660

atgctataaa aatggaaaga tgttgctttc tgagaggatc ttgctaccag tggaacagcc      720

actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc agagactgtc      780

tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga gccaggtaca      840

gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag cgtccgggca      900

gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc tcctccgata      960

actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct ctggatccac     1020

tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc accactgacc     1080

tgggacagta aaacaggtaa gtccgctgtt tgtgtgctgc ctctgaagtc cacactgaac     1140

aaacttcagc ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac     1200

acacagccct ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggc     1260

ctctactaac catgttcatg ttttcttttt ttttctacag gtcctgggtg acgaacag       1318


<210>  159
<211>  1579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  159
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagt                                                  1579


<210>  160
<211>  1080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  160
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtctaga ggccgtccgc      360

cctcggcacc atcctcacga cacccaaata tggcgacggg tgaggaatgg tggggagtta      420

tttttagagc ggtgaggaag gtgggcaggc agcaggtgtt ggcgctctaa aaataactcc      480

cgggagttat ttttagagcg gaggaatggt ggacacccaa atatggcgac ggttcctcac      540

ccgtcgccat atttgggtgt ccgccctcgg ccggggccgc attcctgggg gccgggcggt      600

gctcccgccc gcctcgataa aaggctccgg ggccggcggc ggcccacgag ctacccggag      660

gagcgggagg cgccaagcgt gagtatcgat cttgctacca gtggaacagc cactaaggat      720

tctgcagtga gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg      780

ccaccccctc caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct      840

ttcggtaagt gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg      900

ggcgactcag atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg      960

accttggtta atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat     1020

acggacgagg acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt     1080


<210>  161
<211>  568
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  161
gaatggtgga cacccaaata tggcgacggt tcctcacccg tcgccatatt tgggtgtccg       60

ccctcggccg gggccgcatt cctgggggcc gggcggtgct cccgcccgcc tcgataaaag      120

gctccggggc cggcggcggc ccacgagcta cccggaggag cgggaggcgc caagcgatct      180

tgctaccagt ggaacagcca ctaaggattc tgcagtgaga gcagagggcc agctaagtgg      240

tactctccca gagactgtct gactcacgcc accccctcca ccttggacac aggacgctgt      300

ggtttctgag ccaggtacag tgactccttt cggtaagtgc agtggaagct gtacactgcc      360

caggcaaagc gtccgggcag cgtaggcggg cgactcagat cccagccagt ggacttagcc      420

cctgtttgct cctccgataa ctggggtgac cttggttaat attcaccagc agcctccccc      480

gttgcccctc tggatccact gcttaaatac ggacgaggac agggccctgt ctcctcagct      540

tcaggcacca ccactgacct gggacagt                                         568


<210>  162
<211>  895
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  162
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagagaa tggtggacac ccaaatatgg cgacggttcc      360

tcacccgtcg ccatatttgg gtgtccgccc tcggccgggg ccgcattcct gggggccggg      420

cggtgctccc gcccgcctcg ataaaaggct ccggggccgg cggcggccca cgagctaccc      480

ggaggagcgg gaggcgccaa gcgatcttgc taccagtgga acagccacta aggattctgc      540

agtgagagca gagggccagc taagtggtac tctcccagag actgtctgac tcacgccacc      600

ccctccacct tggacacagg acgctgtggt ttctgagcca ggtacagtga ctcctttcgg      660

taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt aggcgggcga      720

ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg gggtgacctt      780

ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct taaatacgga      840

cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg acagt           895


<210>  163
<211>  1291
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  163
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccctg catgcgaaga      480

tcttcgaaca aggctgtggg ggactgaggg caggctgtaa caggcttggg ggccagggct      540

tatacgtgcc tgggactccc aaagtattac tgttccatgt tcccggcgaa gggccagctg      600

tcccccgcca gctagactca gcacttagtt taggaaccag tgagcaagtc agcccttggg      660

gcagcccata caaggccatg gggctgggca agctgcacgc ctgggtccgg ggtgggcacg      720

gtgcccgggc aacgagctga aagctcatct gctctcaggg gcccctccct ggggacagcc      780

cctcctggct agtcacaccc tgtaggctcc tctatataac ccaggggcac aggggctgcc      840

ctcattctac caccacctcc acagcacaga cagacactca ggagccagcc agcgtcgaga      900

tcttgctacc agtggaacag ccactaagga ttctgcagtg agagcagagg gccagctaag      960

tggtactctc ccagagactg tctgactcac gccaccccct ccaccttgga cacaggacgc     1020

tgtggtttct gagccaggta cagtgactcc tttcggtaag tgcagtggaa gctgtacact     1080

gcccaggcaa agcgtccggg cagcgtaggc gggcgactca gatcccagcc agtggactta     1140

gcccctgttt gctcctccga taactggggt gaccttggtt aatattcacc agcagcctcc     1200

cccgttgccc ctctggatcc actgcttaaa tacggacgag gacagggccc tgtctcctca     1260

gcttcaggca ccaccactga cctgggacag t                                    1291


<210>  164
<211>  1147
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  164
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccctgcatg cgaagatctt cgaacaaggc tgtgggggac      360

tgagggcagg ctgtaacagg cttgggggcc agggcttata cgtgcctggg actcccaaag      420

tattactgtt ccatgttccc ggcgaagggc cagctgtccc ccgccagcta gactcagcac      480

ttagtttagg aaccagtgag caagtcagcc cttggggcag cccatacaag gccatggggc      540

tgggcaagct gcacgcctgg gtccggggtg ggcacggtgc ccgggcaacg agctgaaagc      600

tcatctgctc tcaggggccc ctccctgggg acagcccctc ctggctagtc acaccctgta      660

ggctcctcta tataacccag gggcacaggg gctgccctca ttctaccacc acctccacag      720

cacagacaga cactcaggag ccagccagcg tcgagatctt gctaccagtg gaacagccac      780

taaggattct gcagtgagag cagagggcca gctaagtggt actctcccag agactgtctg      840

actcacgcca ccccctccac cttggacaca ggacgctgtg gtttctgagc caggtacagt      900

gactcctttc ggtaagtgca gtggaagctg tacactgccc aggcaaagcg tccgggcagc      960

gtaggcgggc gactcagatc ccagccagtg gacttagccc ctgtttgctc ctccgataac     1020

tggggtgacc ttggttaata ttcaccagca gcctcccccg ttgcccctct ggatccactg     1080

cttaaatacg gacgaggaca gggccctgtc tcctcagctt caggcaccac cactgacctg     1140

ggacagt                                                               1147


<210>  165
<211>  1490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  165
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gcccttcaga ttaaaaataa ctgaggtaag ggcctgggta      360

ggggaggtgg tgtgagacgc tcctgtctct cctctatctg cccatcggcc ctttggggag      420

gaggaatgtg cccaaggact aaaaaaaggc catggagcca gaggggcgag ggcaacagac      480

ctttcatggg caaaccttgg ggccctgctg aagctttggc ccactacggg tttaggctgc      540

ccatgtaagg aggcaaggcc tggggacacc cgagatgcct ggttataatt aacccagaca      600

tgtggctgcc cccccccccc ccaacacctg ctgcctctaa aaataaccct gtccctggtg      660

gatcccctgc atgcgaagat cttcgaacaa ggctgtgggg gactgagggc aggctgtaac      720

aggcttgggg gccagggctt atacgtgcct gggactccca aagtattact gttccatgtt      780

cccggcgaag ggccagctgt cccccgccag ctagactcag cacttagttt aggaaccagt      840

gagcaagtca gcccttgggg cagcccatac aaggccatgg ggctgggcaa gctgcacgcc      900

tgggtccggg gtgggcacgg tgcccgggca acgagctgaa agctcatctg ctctcagggg      960

cccctccctg gggacagccc ctcctggcta gtcacaccct gtaggctcct ctatataacc     1020

caggggcaca ggggctgccc tcattctacc accacctcca cagcacagac agacactcag     1080

gagccagcca gcgtcgagat cttgctacca gtggaacagc cactaaggat tctgcagtga     1140

gagcagaggg ccagctaagt ggtactctcc cagagactgt ctgactcacg ccaccccctc     1200

caccttggac acaggacgct gtggtttctg agccaggtac agtgactcct ttcggtaagt     1260

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     1320

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     1380

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     1440

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt                1490


<210>  166
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  166
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg ggtacccggg gatcttgcta ccagtggaac agccactaag      360

gattctgcag tgagagcaga gggccagcta agtggtactc tcccagagac tgtctgactc      420

acgccacccc ctccaccttg gacacaggac gctgtggttt ctgagccagg tacaatgact      480

cctttcggta agtgcagtgg aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag      540

gcgggcgact cagatcccag ccagtggact tagcccctgt ttgctcctcc gataactggg      600

gtgaccttgg ttaatattca ccagcagcct cccccgttgc ccctctggat ccactgctta      660

aatacggacg aggacagggc cctgtctcct cagcttcagg caccaccact gacctgggac      720

agt                                                                    723


<210>  167
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  167
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc                            100


<210>  168
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  168
aggttaattt ttaaaaagca gtcaaaagtc caagtggccc ttggcagcat ttactctctc       60

tgtttgctct ggttaataat ctcaggagca caaacattcc aggttaattt ttaaaaagca      120

gtcaaaagtc caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat      180

ctcaggagca caaacattcc                                                  200


<210>  169
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  169
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg g                                                321


<210>  170
<211>  554
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  170
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gtctagaagg ctcagaggca cacaggagtt tctgggctca      360

ccctgccccc ttccaacccc tcagttccca tcctccagca gctgtttgtg tgctgcctct      420

gaagtccaca ctgaacaaac ttcagcctac tcatgtccct aaaatgggca aacattgcaa      480

gcagcaaaca gcaaacacac agccctccct gcctgctgac cttggagctg gggcagaggt      540

cagagacctc tctg                                                        554


<210>  171
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  171
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  172
<211>  393
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  172
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agt                                   393


<210>  173
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  173
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatc                                             144


<210>  174
<211>  288
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  174
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatc                   288


<210>  175
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  175
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tc                                                          432


<210>  176
<211>  199
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  176
cccttcagat taaaaataac tgaggtaagg gcctgggtag gggaggtggt gtgagacgct       60

cctgtctctc ctctatctgc ccatcggccc tttggggagg aggaatgtgc ccaaggacta      120

aaaaaaggcc atggagccag aggggcgagg gcaacagacc tttcatgggc aaaccttggg      180

gccctgctga agctttggc                                                   199


<210>  177
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker


<220>
<221>  misc
<222>  (2)..(2)
<223>  xaa can be any amino acid

<400>  177

Arg Xaa Lys Arg 
1               


<210>  178
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; linker


<220>
<221>  misc
<222>  (2)..(2)
<223>  xaa can be any amino acid

<400>  178

Arg Xaa Arg Arg 
1               


<210>  179
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; AAV construct

<400>  179

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ser Asn Met Ser Ala Gln Ala Arg Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Val Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  180
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  180
ggtacagtga ctcctttcg                                                    19


<210>  181
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  181
ggtacaatga ctcctttcg                                                    19


<210>  182
<211>  865
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  182
ccactacggg tttaggctgc ccatgtaagg aggcaaggcc tggggacacc cgagatgcct       60

ggttataatt aacccagaca tgtggctgcc cccccccccc ccaacacctg ctgcctctaa      120

aaataaccct gtccctggtg gatcccacta cgggtttagg ctgcccatgt aaggaggcaa      180

ggcctgggga cacccgagat gcctggttat aattaaccca gacatgtggc tgcccccccc      240

ccccccaaca cctgctgcct ctaaaaataa ccctgtccct ggtggatccc actacgggtt      300

taggctgccc atgtaaggag gcaaggcctg gggacacccg agatgcctgg ttataattaa      360

cccagacatg tggctgcccc cccccccccc aacacctgct gcctctaaaa ataaccctgt      420

ccctggtgga tcccctgcat gcgaagatct tcgaacaagg ctgtggggga ctgagggcag      480

gctgtaacag gcttgggggc cagggcttat acgtgcctgg gactcccaaa gtattactgt      540

tccatgttcc cggcgaaggg ccagctgtcc cccgccagct agactcagca cttagtttag      600

gaaccagtga gcaagtcagc ccttggggca gcccatacaa ggccatgggg ctgggcaagc      660

tgcacgcctg ggtccggggt gggcacggtg cccgggcaac gagctgaaag ctcatctgct      720

ctcaggggcc cctccctggg gacagcccct cctggctagt cacaccctgt aggctcctct      780

atataaccca ggggcacagg ggctgccctc attctaccac cacctccaca gcacagacag      840

acactcagga gccagccagc gtcga                                            865


<210>  183
<211>  460
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  183
gggctggaag ctacctttga catcatttcc tctgcgaatg catgtataat ttctacagaa       60

cctattagaa aggatcaccc agcctctgct tttgtacaac tttcccttaa aaaactgcca      120

attccactgc tgtttggccc aatagtgaga actttttcct gctgcctctt ggtgcttttg      180

cctatggccc ctattctgcc tgctgaagac actcttgcca gcatggactt aaacccctcc      240

agctctgaca atcctctttc tcttttgttt tacatgaagg gtctggcagc caaagcaatc      300

actcaaagtt caaaccttat cattttttgc tttgttcctc ttggccttgg ttttgtacat      360

cagctttgaa aataccatcc cagggttaat gctggggtta atttataact aagagtgctc      420

tagttttgca atacaggaca tgctataaaa atggaaagat                            460


<210>  184
<211>  445
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  184
ctgcagtcaa gactagttcc caccaactcg attttaaagc cttgcaagaa ggtggcttgt       60

ttgtcccttg caggttcctt tgtcgggcca aactctagaa tgcctccccc tttctttctc      120

attgaagagc agacccaagt ccgggtaaca aggaagggtt tcagggtcct gcccataaaa      180

ggtttttccc ggccgccctc agcaccgccc cgccccgacc cccgcagcat ctccaaagca      240

tgcagagaat gtctccggct gcccccgaca gactgctcca acttggtgtc tttccccaaa      300

tatggagcct gtgtggagtg agtggggcgg cccggggtgg tgagccaagc agacttccat      360

gggcagggag gggcgccagc ggacggcaga ggggtgacat cactgcctag gcggccttta      420

aacccctcac ccagccggcg cccca                                            445


<210>  185
<211>  389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  185
ttgtttgtcc cttgcaggtt cctttgtcgg gccaaactct agaatgcctc cccctttctt       60

tctcattgaa gagcagaccc aagtccgggt aacaaggaag ggtttcaggg tcctgcccat      120

aaaaggtttt tcccggccgc cctcagcacc gccccgcccc gacccccgca gcatctccaa      180

agcatgcaga gaatgtctcc ggctgccccc gacagactgc tccaacttgg tgtctttccc      240

caaatatgga gcctgtgtgg agtgagtggg gcggcccggg gtggtgagcc aagcagactt      300

ccatgggcag ggaggggcgc cagcggacgg cagaggggtg acatcactgc ctaggcggcc      360

tttaaacccc tcacccagcc ggcgcccca                                        389


<210>  186
<211>  1343
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  186
gaattcagga cgtaatcagt ggctggaaag caagagctct agaggagctc cagcttatta       60

tgacccttcc ttcagatgcc acaaggaggt gctggagttc tatgcaccaa tagcttaaac      120

cagccaggct ggctgtagtg gattgagcgt ctgaggctgc acctctctgg cctgcagcca      180

gttcctgggt gagactgacc ctgcctgagg gttctctcct tccctctctc tactcctttc      240

ctccctctcc ctctccctct ctctgtttcc tgaggtttcc aggattgggg atgggactca      300

gagacaccac taaagcctta ccttttaaga agttgcattc agtgagtgtg tgagacatag      360

cacagatagg ggcagaggag agctggttct gtctccactg tgtttggtct tgggtactga      420

actcagacca tcaggtgtga tagcagttgt ctttaaccct aaccctgagc ctgtctcacc      480

tgtcccttcc caagaccact gaagctaggt gcaagataag tggggaccct ttctgaggtg      540

gtaggatctt tcacgataag gactattttg aagggaggga gggtgacact gtcctagtcc      600

tcttacccta gtgtcctcca gccttgccag gccttaaaca tccgcccatt gtcaccgctc      660

tagaaggggc cagggttgac ttgctgctaa acaaggcact ccctagagaa gcacccgcta      720

gaagcatacc atacctgtgg gcaggatgac ccatgttctg ccacgcactt ggtagccttg      780

gaaaggccac tttgaacctc aattttctca actgttaaat ggggtggtaa ctgctatctc      840

ataataaagg ggaacgtgaa aggaaggcgt ttgcatagtg cctggttgtg cagccaggct      900

gcagtcaaga ctagttccca ccaactcgat tttaaagcct tgcaagaagg tggcttgttt      960

gtcccttgca ggttcctttg tcgggccaaa ctctagaatg cctccccctt tctttctcat     1020

tgaagagcag acccaagtcc gggtaacaag gaagggtttc agggtcctgc ccataaaagg     1080

tttttcccgg ccgccctcag caccgccccg ccccgacccc cgcagcatct ccaaagcatg     1140

cagagaatgt ctccggctgc ccccgacaga ctgctccaac ttggtgtctt tccccaaata     1200

tggagcctgt gtggagtgag tggggcggcc cggggtggtg agccaagcag acttccatgg     1260

gcagggaggg gcgccagcgg acggcagagg ggtgacatca ctgcctaggc ggcctttaaa     1320

cccctcaccc agccggcgcc cca                                             1343


<210>  187
<211>  433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  187
gatcccatgt cccatcagag ctaaaagccc caggaggaga gggtggctgg tttgtcccca       60

caaacccctg ggattcccgg ctccccagcc ccttgcccct ctctccagcc agactctatt      120

gaactccccc tcttctcaaa ctcggggcca gagaacagtg aagtaggagc agccgtaagt      180

ccgggcaggg tcctgtccat aaaaggcttt tcccgggccg gctccccgcc ggcagcgtgc      240

cccgccccgg cccgctccat ctccaaagca tgcagagaat gtctcggcag ccccggtaga      300

ctgctccaac ttggtgtctt tccccaaata tggagcctgt gtggagtcac tgggggagcc      360

gggggtgggg agcggagccg gcttcctcta gcagggaggg ggccgaggag cgagccagtg      420

ggggaggctg aca                                                         433


<210>  188
<211>  340
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  188
ggggtttgtg gggacaaacc agccaccctc tcctcctggg gcttttaact ctgatgggac       60

atggggatcc aacctttcct gaggacctac tccacaccag gccctttgca gtgctctcat      120

tgaatactca cagctacagt gtgagggtgt aattacatcc ccattttata gatgaggaaa      180

ctgaggcccc gagtgcgtct tcctcaaggc cacatggtga atggtaagtg gcacatcctg      240

cacacctctg ccaacccgca tgggtgcagg agaggtggtc agacccaccc tttcaattgg      300

accaccctgc tcaggttgag aagagctttc agtgcaagta                            340


<210>  189
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (446)..(446)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (463)..(463)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (510)..(510)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (555)..(555)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (560)..(560)
<223>  n is a, c, g, or t

<400>  189
ccctnggtca ctgtgctctc caagatcccc tgcgtgcacc gtggccatcc cataccccag       60

cctttcaccc gctgcccccc gtgcccccac ccaccaggag cctcccagcc ctgcagtgag      120

cacaggggaa agccagccat gaagtcaggg caaaaaactc cgcgagcgcc tgcctataaa      180

aggatttact tcatcagagc ccccgggtcc tgcttcctcc ctgccccaaa accactgggg      240

ctgaggcacg cggggaatgc tccggcacgg gctttagtca ctggttttcg gagtctttcc      300

ccaaatatgg tgtctgggct ggaatcatgg tgtgctgtgg ggctggggga gggctggggg      360

ctgtcccgtg ggccgctgac atcactgtcc ggccttttag cacagcgtcg gcctccgaac      420

tgtgcagtgt gctggcagcc accgancatc acatcgcccc tcncctccgt gagtcgctgc      480

ttgtgaatcc tgcggggttg ctggagggan ggcatcctgt ggctgccggc ccctgggatg      540

gggatgctgc tgtanggatn aagatgctgc tcctcacatc ggggttttgc tccctggact      600


<210>  190
<211>  509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  190
ctgcagtcaa gactagttcc caccaactcg attttaaagc cttgcaagaa ggtggcttgt       60

ttgtcccttg caggttcctt tgtcgggcca aactctagaa tgcctccccc tttctttctc      120

attgaagagc agacccaagt ccgggtaaca aggaagggtt tcagggtcct gcccataaaa      180

ggtttttccc ggccgccctc agcaccgccc cgccccgacc cccgcagcat ctccaaagca      240

tgcagagaat gtctccggct gcccccgaca gactgctcca acttggtgtc tttccccaaa      300

tatggagcct gtgtggagtg agtggggcgg cccggggtgg tgagccaagc agacttccat      360

gggcagggag gggcgccagc ggacggcaga ggggtgacat cactgcctag gcggccttta      420

aacccctcac ccagccggcg ccccagcccg tctgccccag cccagacacc gaagctactc      480

tccttccagt ccacaaacga ccaagcctt                                        509


<210>  191
<211>  448
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  191
agtgcaagtg ggttttagga ccaggatgag gcggggtggg ggtgcctacc tgacgaccga       60

ccccgaccca ctggacaagc acccaacccc cattccccaa attgcgcatc ccctatcaga      120

gagggggagg ggaaacagga tgcggcgagg cgcgtgcgca ctgccagctt cagcaccgcg      180

gacagtgcct tcgcccccgc ctggcggcgc gcgccaccgc cgcctcagca ctgaaggcgc      240

gctgacgtca ctcgccggtc ccccgcaaac tccccttccc ggccaccttg gtcgcgtccg      300

cgccgccgcc ggcccagccg gaccgcacca cgcgaggcgc gagatagggg ggcacgggcg      360

cgaccatctg cgctgcggcg ccggcgactc agcgctgcct cagtctgcgg tgggcagcgg      420

aggagtcgtg tcgtgcctga gagcgcag                                         448


<210>  192
<211>  429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  192
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgc                                                              429


<210>  193
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  193
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgcg gtgggcagcg gaggagtcgt gtcgtgcctg agagcgcagg gcgcgcc         477


<210>  194
<211>  571
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  194
cctgcagggc ccactagtat ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg       60

accaggatga ggcggggtgg gggtgcctac ctgacgaccg accccgaccc actggacaag      120

cacccaaccc ccattcccca aattgcgcat cccctatcag agagggggag gggaaacagg      180

atgcggcgag gcgcgtgcgc actgccagct tcagcaccgc ggacagtgcc ttcgcccccg      240

cctggcggcg cgcgccaccg ccgcctcagc actgaaggcg cgctgacgtc actcgccggt      300

cccccgcaaa ctccccttcc cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc      360

ggaccgcacc acgcgaggcg cgagataggg gggcacgggc gcgaccatct gcgctgcggc      420

gccggcgact cagcgctgcc tcagtctgcg gtgggcagcg gaggagtcgt gtcgtgcctg      480

agagcgcagc tgtgctcctg ggcaccgcgc agtccgcccc cgcggctcct ggccagacca      540

cccctaggac cccctgcccc aagtcgcagc c                                     571


<210>  195
<211>  229
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  195
agctgaatgg ggtccgcctc ttttccctgc ctaaacagac aggaactcct gccaattgag       60

ggcgtcaccg ctaaggctcc gccccagcct gggctccaca accaatgaag ggtaatctcg      120

acaaagagca aggggtgggg cgcgggcgcg caggtgcagc agcacacagg ctggtcggga      180

gggcggggcg cgacgtctgc cgtgcggggt cccggcatcg gttgcgcgc                  229


<210>  196
<211>  1675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  196
gtctgcaagc agacctggca gcattgggct ggccgccccc cagggcctcc tcttcatgcc       60

cagtgaatga ctcaccttgg cacagacaca atgttcgggg tgggcacagt gcctgcttcc      120

cgccgcaccc cagcccccct caaatgcctt ccgagaagcc cattgagtag ggggcttgca      180

ttgcacccca gcctgacagc ctggcatctt gggataaaag cagcacagcc ccctaggggc      240

tgcccttgct gtgtggcgcc accggcggtg gagaacaagg ctctattcag cctgtgccca      300

ggaaagggga tcaggggatg cccaggcatg gacagtgggt ggcagggggg gagaggaggg      360

ctgtctgctt cccagaagtc caaggacaca aatgggtgag gggactgggc agggttctga      420

ccctgtggga ccagagtgga gggcgtagat ggacctgaag tctccaggga caacagggcc      480

caggtctcag gctcctagtt gggcccagtg gctccagcgt ttccaaaccc atccatcccc      540

agaggttctt cccatctctc caggctgatg tgtgggaact cgaggaaata aatctccagt      600

gggagacgga ggggtggcca gggaaacggg gcgctgcagg aataaagacg agccagcaca      660

gccagctcat gcgtaacggc tttgtggagc tgtcaaggcc tggtctctgg gagagaggca      720

cagggaggcc agacaaggaa ggggtgacct ggagggacag atccaggggc taaagtcctg      780

ataaggcaag agagtgccgg ccccctcttg ccctatcagg acctccactg ccacatagag      840

gccatgattg acccttagac aaagggctgg tgtccaatcc cagcccccag ccccagaact      900

ccagggaatg aatgggcaga gagcaggaat gtgggacatc tgtgttcaag ggaaggactc      960

caggagtctg ctgggaatga ggcctagtag gaaatgaggt ggcccttgag ggtacagaac     1020

aggttcattc ttcgccaaat tcccagcacc ttgcaggcac ttacagctga gtgagataat     1080

gcctgggtta tgaaatcaaa aagttggaaa gcaggtcaga ggtcatctgg tacagccctt     1140

ccttcccttt tttttttttt tttttttttg tgagacaagg tctctctctg ttgcccaggc     1200

tggagtggcg caaacacagc tcactgcagc ctcaacctac tgggctcaag caatcctcca     1260

gcctcagcct cccaaagtgc tgggattaca agcatgagcc accccactca gccctttcct     1320

tcctttttaa ttgatgcata ataattgtaa gtattcatca tggtccaacc aaccctttct     1380

tgacccacct tcctagagag agggtcctct tgattcagcg gtcagggccc cagacccatg     1440

gtctggctcc aggtaccacc tgcctcatgc aggagttggc gtgcccagga agctctgcct     1500

ctgggcacag tgacctcagt ggggtgaggg gagctctccc catagctggg ctgcggccca     1560

accccacccc ctcaggctat gccagggggt gttgccaggg gcacccgggc atcgccagtc     1620

tagcccactc cttcataaag ccctcgcatc ccaggagcga gcagagccag agcat          1675


<210>  197
<211>  2043
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  197
agctctgagc tcctcctctg ctcgcccaat ccttccaacc ccctatggtg gtatggctga       60

cacagaaaat gtctgctcct gtatgggaca tttgcccctc ttctccaaat ataagacagg      120

atgaggccta gcttttgctg ctccaaagtt ttaaaagaac acattgcacg gcatttaggg      180

actctaaagg gtggaggagg aatgagggaa ttgcatcatg ccaaggctgg tcctcatcca      240

tcactgcttc cagggcccag agtggcttcc aggaagtatt cttacaaagg aagcccgatc      300

tgtagctaac actcagagcc cattttcctg cgttaacccc tcccgacctc atatacagga      360

gtaacatgat cagtgacctg ggggagctgg ccaaactgcg ggacctgccc aagctgaggg      420

ccttggtgct gctggacaac ccctgtgccg atgagactga ctaccgccag gaggccctgg      480

tgcagatggc acacctagag cgcctagaca aagagtacta tgaggacgag gaccgggcag      540

aagctgagga gatccgacag aggctgaagg aggaacagga gcaagaactc gacccggacc      600

aagacatgga accgtacctc ccgccaactt agtggctcct ctagcctgca gggacagtaa      660

aggtgatggc aggaaggcag cccccggagg tcaaaggctg ggcacgcggg aggagaggcc      720

agagtcagag gctgcgggta tctcagatat gaaggaaaga tgagagaggc tcaggaagag      780

gtaagaaaag acacaagaga ccagagaagg gagaagaatt agagagggag gcagaggacc      840

gctgtctcta cagacatagc tggtagagac tgggaggaag ggatgaaccc tgagcgcatg      900

aagggaagga ggtggctggt ggtatatgga ggatgtagct gggccaggga aaagatcctg      960

cactaaaaat ctgaagctaa aaataacagg acacggggtg gagaggcgaa aggagggcag     1020

agtgaggcag agagactgag aggcctgggg atgtgggcat tccggtaggg cacacagttc     1080

acttgtcttc tctttttcca ggaggccaaa gatgctgacg tcaagaactc ataatacccc     1140

agtggggacc accgcattca tagccctgtt acaagaagtg ggagatgttc ctttttgtcc     1200

cagactggaa atccgttaca tcccgaggct caggttctgt ggtggtcatc tctgtgtggc     1260

ttgttctgtg ggcctaccta aagtcctaag cacagctctc aagcagatcc gaggcgacta     1320

agatgctagt aggggttgtc tggagagaag agccgaggag gtgggctgtg atggatcagt     1380

tcagctttca aataaaaagg cgtttttata ttctgtgtcg agttcgtgaa cccctgtggt     1440

gggcttctcc atctgtctgg gttagtacct gccactatac tggaataagg ggacgcctgc     1500

ttccctcgag ttggctggac aaggttatga gcatccgtgt acttatgggg ttgccagctt     1560

ggtcctggat cgcccgggcc cttcccccac ccgttcggtt ccccaccacc acccgcgctc     1620

gtacgtgcgt ctccgcctgc agctcttgac tcatcggggc ccccgggtca catgcgctcg     1680

ctcggctcta taggcgccgc cccctgccca ccccccgccc gcgctgggag ccgcagccgc     1740

cgccactcct gctctctctg cgccgaagct tcgaggggct cgcatctctc cttcacgcgc     1800

ccgccgccct acctgaggcc gccatccacg ccggttgagt cgcgttctgc cgcctcccgc     1860

ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc     1920

gggcctttgt ccggcgctcc cttggagcct acctagactc agccggctct ccacgctttg     1980

cctgaccctg cttgctcaac tctacgtctt tgtttcgttt tctgttctgc gccgttacag     2040

atc                                                                   2043


<210>  198
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  198
gaggaggagg agagagaccg ggagggcgcc cgggaggcag ggcgcgcgca cactccgagg       60


<210>  199
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  199
gatgctgacg aaggctcgcg aggctgtgag cagccacagt gccctgctca gaagccccgg       60


<210>  200
<211>  364
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  200
acttgtggac taagtttgtt cgcatcccct tctccaaccc cctcagtaca tcaccctggg       60

ggaacagggt ccacttgctc ctgggcccac acagtcctgc agtattgtgt atataaggcc      120

agggcaaaga ggagcaggtt ttaaagtgaa aggcaggcag gtgttgggga ggcagttacc      180

ggggcaacgg gaacagggcg tttcggaggt ggttgccatg gggacctgga tgctgacgaa      240

ggctcgcgag gctgtgagca gccacagtgc cctgctcaga agccccaagc tcgtcagtca      300

agccggttct ccgtttgcac tcaggagcac gggcaggcga gtggccccta gttctggggg      360

cagc                                                                   364


<210>  201
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  201
gtctcccgcg cccgcgcccg tgtcgccgcc gtgcccgcga gcgggagccg gagtcgccgc       60


<210>  202
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  202
cgtgtgcaga tgcagggcgc cggtgccctg cgggtgcggg tgcaggagca gcgtgtgcag       60


<210>  203
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  203
ccccacgcca ccctttctgg tcatctcccc tcccgccccg cccctgcgca cactccctcg       60


<210>  204
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  204
tctccccggt aaagtctcgc ggtgctgccg ggctcagccc cgtctcctcc tcttgctccc       60


<210>  205
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  205
cgcctcctcc gcccgccgcc cgggagccgc agccgccgcc gccactgcca ctcccgctct       60


<210>  206
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  206
tgggtgcccc cacccttccc ccatcctcct cccttcccca ctccaccctc gtcggtcccc       60


<210>  207
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  207
aaaaaaaaaa aaaaagccca ccctccagcc tcgctgcaaa gagaaaaccg gagcagccgc       60


<210>  208
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  208
tctcgcactc tcccttctcc tttataaagg ccggaacagc tgaaagggtg gcaacttctc       60


<210>  209
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  209
gccgcgtcca cctgtcggcc gggcccagcc gagcgcgcag cgggcacgcc gcgcgcgcgg       60


<210>  210
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  210
gcgccccgcc cccggcgctg agtcctgtga cagcccccgg gccgcctgca cttgcagcct       60


<210>  211
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  211
aaagaagagt cccctattcc tgaaacttac tctgtccgtg gtgctgaaac attgtaccga       60


<210>  212
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  212
cgtcctcaaa gagcagcaag ccttctccat cttaatttga ctctaccgca gagcagactt       60


<210>  213
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  213
atgcagctat tctgttgtat tctcattctc actctccctc ccttctctca ctctcactct       60


<210>  214
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  214
catgttagcg tccccagctg cagcccaggg agggagagag gctgcgctca gtctgagagt       60


<210>  215
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  215
tgacgtcaga gagagagttt aaaacagagg gagacggttg agagcacaca agccgcttta       60


<210>  216
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  216
gagtgaaaat aaaagattgt ataaatcgtg gggcatgtgg aattgtgtgt gcctgtgcgt       60


<210>  217
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  217
gccgcggcga ggaagctcca taaaagccct gtcgcgaccc gctctctgca ccccatccgc       60


<210>  218
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  218
cagtcctaag tataagccct ataaaatgat gggctttgaa atgctggtca gggtagagtg       60


<210>  219
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  219
ttttccatta atgttttcag actgctgttg accacaggta actgaaatca tggaaagaga       60


<210>  220
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  220
tggtcatatg agcagaaatg atgagaaaag cactttttaa tcttttcgca cttgctctgc       60


<210>  221
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  221
aatagccaga gcagaagcct atataggtgg ccatcccacc tccaggctca cttcccgaca       60


<210>  222
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  222
cagcgctcag attttgcagc ataaatttgc atccaggaca gaccagagca gaggctgagg       60


<210>  223
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  223
gcacgcacgc gcgcgcaggg ccaagcccga ggcagctcgc ccgcagctcg cactcgcagg       60


<210>  224
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  224
cccgcctctg gctcgcccga ggacgcgctg gcacgcctcc caccccctca ctctgactcc       60


<210>  225
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  225
cactgggctc cctttccctc aaatgctctg gggctctccg cgctttcctg agtccgggct       60


<210>  226
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  226
cacagaaaac tcctctgggc cacgcttccc gcctcgccga ggtctcccca gtctgcccct       60


<210>  227
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  227
ctctgccccc gcctaccccg gagccgtgca gccgcctctc cgaatctctc tcttctcctg       60


<210>  228
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  228
ctggatttat aatcgcccta taaagctcca gaggcggtca ggcacctgca gaggagcccc       60


<210>  229
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  229
gggacgcgcg ggcggggtgg gctgtgcccc gcgggaaccc cgccggcctg tgcgcttgct       60

g                                                                       61


<210>  230
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  230
ctccctcccg cgctccccgc gctcgggcgc cgcagagctg tccagcttca gtgccgaacc       60


<210>  231
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  231
gtactggtgt acaaggacaa ggtgactttt tttcttttcc cagattgaaa gggccaaaga       60


<210>  232
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  232
cctccgccgc tcagccccgg actccttacg tcagggtagc ggggtccccc ctccgcgcgg       60


<210>  233
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  233
ccaggagagc tcggcaagta tataaggaca gaggagcgcg ggaccaagcg gcggcgaagg       60


<210>  234
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  234
ttccttcagc tgtgtcttaa agtaaatctt gttgtggagc ggagccctca gctgagggag       60


<210>  235
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  235
gtaagtatct tcttcttccc ctcgtgagtc cctccccttt tccagaatca cttgcactgt       60


<210>  236
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  236
ggggcggagc ggagacagta ccttcggaga taatcctttc tcctgccgca gtggagagga       60


<210>  237
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  237
ccctgcctag tctccatata aaagcggcgc cgcctccccg ccctctctca ctccccgctc       60


<210>  238
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  238
gggcggccca gccccaggtt acgtcgtccc cagaaagaat ctggccaaca gtctggccgt       60


<210>  239
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  239
ggcaggttct cttacatcga ccgcttaaga gtcgcgctgt aagaagcaac acctcctcct       60

cgcctccgcc atccacccgg cagccgcgaa gcagcaacc                              99


<210>  240
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  240
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  241
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  241
gtgagtatct cagggatcca gacatgggga tatgggaggt gcctctgatc ccagggctca       60

ctgtgggtct ctctgttcac ag                                                82


<210>  242
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  242
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  243
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  243
ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc tctca            55


<210>  244
<211>  127
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  244
gatctttttc cctctgccaa aaattatggg gacatcatga agccccttga gcatctgact       60

tctggctaat aaaggaaatt tattttcatt gcaatagtgt gttggaattt tttgtgtctc      120

tcactcg                                                                127


<210>  245
<211>  130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  245
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct                                                             130


<210>  246
<211>  106
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  246
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtgg                     106


<210>  247
<211>  143
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  247
gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caa                                              143


<210>  248
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; regulatory sequence

<400>  248
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                 110


<210>  249
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; transcription start site

<400>  249
tcattctacc                                                              10


<210>  250
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge

<400>  250

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly 
            


<210>  251
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; hinge

<400>  251

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Ala 
1               5                   10                  15      


Ala Gly Gly 
            


<210>  252
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  252

Glu Asp Thr Ala Val Tyr Tyr 
1               5           


<210>  253
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  253

Glu Asp Thr Ala Val Tyr Tyr 
1               5           


<210>  254
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  254

Asp Glu Ala Asp Tyr Tyr 
1               5       


<210>  255
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  255

Asp Leu Ser Gly Tyr Tyr 
1               5       


<210>  256
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  256

Glu Asp Thr Ala Val Tyr 
1               5       


<210>  257
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  257

Glu Asp Val Ala Thr Tyr Tyr 
1               5           


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  258

Glu Asp Phe Ala Val Tyr Tyr 
1               5           


<210>  259
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; sulfation site

<400>  259

Glu Asp Phe Ala Thr Tyr Tyr 
1               5           


<210>  260
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IgG1

<400>  260

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  261
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IgG2

<400>  261

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
65                  70                  75                  80  


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  262
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct; IgG4

<400>  262

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  263
<211>  1283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  263
taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc tgcctgctga       60

ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg ctcccgtttg      120

acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc ctctcccaga      180

acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct ataaggcgag      240

gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag ctgctaagtt      300

tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca gtgcccagaa      360

aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg gcagggggag      420

gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa gatcttcgaa      480

caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg cttatacgtg      540

cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc tgtcccccgc      600

cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg gggcagccca      660

tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca cggtgcccgg      720

gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag cccctcctgg      780

ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg ccctcattct      840

accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga gatcttgcta      900

ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc      960

tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt     1020

ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc     1080

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt     1140

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc     1200

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg     1260

caccaccact gacctgggac agt                                             1283


<210>  264
<211>  95
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; enhancer

<400>  264
taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc tgcctgctga       60

ccttggagct ggggcagagg tcagagacct ctctg                                  95


<210>  265
<211>  347
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic constuct; regulatory sequence

<400>  265
ctcccgtttg acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc       60

ctctcccaga acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct      120

ataaggcgag gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag      180

ctgctaagtt tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca      240

gtgcccagaa aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg      300

gcagggggag gcatcttcct caggacatcg ggtcctagag ggagcgg                    347


<210>  266
<211>  433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; promoter

<400>  266
ccctgcatgc gaagatcttc gaacaaggct gtgggggact gagggcaggc tgtaacaggc       60

ttgggggcca gggcttatac gtgcctggga ctcccaaagt attactgttc catgttcccg      120

gcgaagggcc agctgtcccc cgccagctag actcagcact tagtttagga accagtgagc      180

aagtcagccc ttggggcagc ccatacaagg ccatggggct gggcaagctg cacgcctggg      240

tccggggtgg gcacggtgcc cgggcaacga gctgaaagct catctgctct caggggcccc      300

tccctgggga cagcccctcc tggctagtca caccctgtag gctcctctat ataacccagg      360

ggcacagggg ctgccctcat tctaccacca cctccacagc acagacagac actcaggagc      420

cagccagcgt cga                                                         433


<210>  267
<211>  2154
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  267
caggtgcagc tggttgaatc tggtggtggt gttgtgcagc ctggcagaag cctgagactg       60

tcttgtgctg cctctggctt caccttcagc agctttggca tgcactgggt tagacaggcc      120

cctggcaaag gcctggaatg ggttgcagtg atcagctttg atggcagcat caagtactct      180

gtggactctg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgttc      240

ctccagatga acagcctgag agctgaggac acagcagtgt actactgtgc cagagacagg      300

ctgaactact atgacagctc tggctactac cactacaagt actatggcat ggctgtgtgg      360

ggccagggca ccacagttac agtgtcctct gccagcacaa agggcccctc tgttttccct      420

ctggctcctt gctctagaag cacctctgag tctacagctg ccctgggctg cctggtcaag      480

gattactttc ctgagcctgt gactgtgtcc tggaactctg gtgctctgac ctctggggtg      540

cacacctttc cagctgtgct gcagtcctct ggcctgtact ctctgtcctc tgtggtcaca      600

gtgcccagct ccaattttgg cacccagacc tacacctgta atgtggacca caagcctagc      660

aacaccaagg tggacaagac tgtggaaaga aagtgctgtg tggaatgccc tccttgtcct      720

gctcctccag tggctggacc ctctgtgttc ctgtttcctc caaagcctaa ggacaccctg      780

atgatcagca gaacccctga agtgacctgt gtggtggtgg atgtgtccca tgaggaccct      840

gaggtgcagt tcaattggta tgtggatggg gttgaagtgc acaatgccaa gaccaagcct      900

agagaggaac agttcaacag caccttcaga gtggtgtctg tgctgacagt ggtgcatcag      960

gactggctga atggcaaaga gtacaagtgc aaggtgtcca acaagggcct gcctgctcct     1020

attgagaaaa ccatcagcaa gaccaaaggc cagcctaggg aaccccaggt gtacacactg     1080

cctccaagca gagaagagat gaccaagaac caggtgtccc tgacctgtct ggttaagggc     1140

ttctacccct ctgacattgc tgtggaatgg gagagcaatg gccagccaga gaacaactac     1200

aagaccacac ctcctatgct ggactcagat ggctcattct tcctgtacag caagctgact     1260

gtggacaagt ccaggtggca gcagggcaat gtgttcagct gctctgtgat gcatgaggcc     1320

ctgcacaacc actacaccca gaagtctctg tctctgagcc ctggcaagag aaagagaaga     1380

ggctctggag aaggcagagg ctccctgctg acatgtgggg atgttgaaga gaatcctggg     1440

cctatgtata ggatgcaact gctcctcctg attgctctga gcctggctct tgtgaccaac     1500

tctcagtctg ttctgaccca gcctccttct gtgtctgctg ccccaggcca gaaagtgacc     1560

atcagctgtt ctggcagcag cagcaacatt ggcaacaact atgtgtcttg gtatcagcag     1620

ctccctggca cagcccctaa actgctgatc tatgacaaca acaagaggcc ctctggcatc     1680

cctgacagat tttctggctc caagtctggc accagcacca cactgggaat cactggcctg     1740

cagacagggg atgaagctga ctactattgt ggcacctggg acagcaggct gtctgctgtt     1800

gtttttggtg gtggcaccaa actgacagtg ctgggccagc caaaggctaa ccccacagtg     1860

acactgttcc ctccaagctc tgaggaactg caggctaaca aggccacact tgtgtgcctg     1920

atctctgact tctaccctgg ggctgtgaca gtggcttgga aggctgatgg aagccctgtg     1980

aaggctgggg ttgagacaac aaagcccagc aagcagagca acaacaaata tgctgccagc     2040

agctatctga gcctgacacc tgagcagtgg aagtcccaca gatcctacag ctgtcaagtg     2100

acccatgagg gctccacagt ggaaaagaca gtggccccta cagagtgctc ctga           2154


<210>  268
<211>  2214
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  268
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

caggtgcagc tggttgaatc tggtggtggt gttgtgcagc ctggcagaag cctgagactg      120

tcttgtgctg cctctggctt caccttcagc agctttggca tgcactgggt tagacaggcc      180

cctggcaaag gcctggaatg ggttgcagtg atcagctttg atggcagcat caagtactct      240

gtggactctg tgaagggcag attcaccatc tccagagaca acagcaagaa caccctgttc      300

ctccagatga acagcctgag agctgaggac acagcagtgt actactgtgc cagagacagg      360

ctgaactact atgacagctc tggctactac cactacaagt actatggcat ggctgtgtgg      420

ggccagggca ccacagttac agtgtcctct gccagcacaa agggcccctc tgttttccct      480

ctggctcctt gctctagaag cacctctgag tctacagctg ccctgggctg cctggtcaag      540

gattactttc ctgagcctgt gactgtgtcc tggaactctg gtgctctgac ctctggggtg      600

cacacctttc cagctgtgct gcagtcctct ggcctgtact ctctgtcctc tgtggtcaca      660

gtgcccagct ccaattttgg cacccagacc tacacctgta atgtggacca caagcctagc      720

aacaccaagg tggacaagac tgtggaaaga aagtgctgtg tggaatgccc tccttgtcct      780

gctcctccag tggctggacc ctctgtgttc ctgtttcctc caaagcctaa ggacaccctg      840

atgatcagca gaacccctga agtgacctgt gtggtggtgg atgtgtccca tgaggaccct      900

gaggtgcagt tcaattggta tgtggatggg gttgaagtgc acaatgccaa gaccaagcct      960

agagaggaac agttcaacag caccttcaga gtggtgtctg tgctgacagt ggtgcatcag     1020

gactggctga atggcaaaga gtacaagtgc aaggtgtcca acaagggcct gcctgctcct     1080

attgagaaaa ccatcagcaa gaccaaaggc cagcctaggg aaccccaggt gtacacactg     1140

cctccaagca gagaagagat gaccaagaac caggtgtccc tgacctgtct ggttaagggc     1200

ttctacccct ctgacattgc tgtggaatgg gagagcaatg gccagccaga gaacaactac     1260

aagaccacac ctcctatgct ggactcagat ggctcattct tcctgtacag caagctgact     1320

gtggacaagt ccaggtggca gcagggcaat gtgttcagct gctctgtgat gcatgaggcc     1380

ctgcacaacc actacaccca gaagtctctg tctctgagcc ctggcaagag aaagagaaga     1440

ggctctggag aaggcagagg ctccctgctg acatgtgggg atgttgaaga gaatcctggg     1500

cctatgtata ggatgcaact gctcctcctg attgctctga gcctggctct tgtgaccaac     1560

tctcagtctg ttctgaccca gcctccttct gtgtctgctg ccccaggcca gaaagtgacc     1620

atcagctgtt ctggcagcag cagcaacatt ggcaacaact atgtgtcttg gtatcagcag     1680

ctccctggca cagcccctaa actgctgatc tatgacaaca acaagaggcc ctctggcatc     1740

cctgacagat tttctggctc caagtctggc accagcacca cactgggaat cactggcctg     1800

cagacagggg atgaagctga ctactattgt ggcacctggg acagcaggct gtctgctgtt     1860

gtttttggtg gtggcaccaa actgacagtg ctgggccagc caaaggctaa ccccacagtg     1920

acactgttcc ctccaagctc tgaggaactg caggctaaca aggccacact tgtgtgcctg     1980

atctctgact tctaccctgg ggctgtgaca gtggcttgga aggctgatgg aagccctgtg     2040

aaggctgggg ttgagacaac aaagcccagc aagcagagca acaacaaata tgctgccagc     2100

agctatctga gcctgacacc tgagcagtgg aagtcccaca gatcctacag ctgtcaagtg     2160

acccatgagg gctccacagt ggaaaagaca gtggccccta cagagtgctc ctga           2214


<210>  269
<211>  4118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  269
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcgccg     1740

ccaccatgta cagaatgcag ctgctgctgc tcattgccct gtctctggcc ctggtcacca     1800

attctcaggt gcagctggtt gaatctggtg gtggtgttgt gcagcctggc agaagcctga     1860

gactgtcttg tgctgcctct ggcttcacct tcagcagctt tggcatgcac tgggttagac     1920

aggcccctgg caaaggcctg gaatgggttg cagtgatcag ctttgatggc agcatcaagt     1980

actctgtgga ctctgtgaag ggcagattca ccatctccag agacaacagc aagaacaccc     2040

tgttcctcca gatgaacagc ctgagagctg aggacacagc agtgtactac tgtgccagag     2100

acaggctgaa ctactatgac agctctggct actaccacta caagtactat ggcatggctg     2160

tgtggggcca gggcaccaca gttacagtgt cctctgccag cacaaagggc ccctctgttt     2220

tccctctggc tccttgctct agaagcacct ctgagtctac agctgccctg ggctgcctgg     2280

tcaaggatta ctttcctgag cctgtgactg tgtcctggaa ctctggtgct ctgacctctg     2340

gggtgcacac ctttccagct gtgctgcagt cctctggcct gtactctctg tcctctgtgg     2400

tcacagtgcc cagctccaat tttggcaccc agacctacac ctgtaatgtg gaccacaagc     2460

ctagcaacac caaggtggac aagactgtgg aaagaaagtg ctgtgtggaa tgccctcctt     2520

gtcctgctcc tccagtggct ggaccctctg tgttcctgtt tcctccaaag cctaaggaca     2580

ccctgatgat cagcagaacc cctgaagtga cctgtgtggt ggtggatgtg tcccatgagg     2640

accctgaggt gcagttcaat tggtatgtgg atggggttga agtgcacaat gccaagacca     2700

agcctagaga ggaacagttc aacagcacct tcagagtggt gtctgtgctg acagtggtgc     2760

atcaggactg gctgaatggc aaagagtaca agtgcaaggt gtccaacaag ggcctgcctg     2820

ctcctattga gaaaaccatc agcaagacca aaggccagcc tagggaaccc caggtgtaca     2880

cactgcctcc aagcagagaa gagatgacca agaaccaggt gtccctgacc tgtctggtta     2940

agggcttcta cccctctgac attgctgtgg aatgggagag caatggccag ccagagaaca     3000

actacaagac cacacctcct atgctggact cagatggctc attcttcctg tacagcaagc     3060

tgactgtgga caagtccagg tggcagcagg gcaatgtgtt cagctgctct gtgatgcatg     3120

aggccctgca caaccactac acccagaagt ctctgtctct gagccctggc aagagaaaga     3180

gaagaggctc tggagaaggc agaggctccc tgctgacatg tggggatgtt gaagagaatc     3240

ctgggcctat gtataggatg caactgctcc tcctgattgc tctgagcctg gctcttgtga     3300

ccaactctca gtctgttctg acccagcctc cttctgtgtc tgctgcccca ggccagaaag     3360

tgaccatcag ctgttctggc agcagcagca acattggcaa caactatgtg tcttggtatc     3420

agcagctccc tggcacagcc cctaaactgc tgatctatga caacaacaag aggccctctg     3480

gcatccctga cagattttct ggctccaagt ctggcaccag caccacactg ggaatcactg     3540

gcctgcagac aggggatgaa gctgactact attgtggcac ctgggacagc aggctgtctg     3600

ctgttgtttt tggtggtggc accaaactga cagtgctggg ccagccaaag gctaacccca     3660

cagtgacact gttccctcca agctctgagg aactgcaggc taacaaggcc acacttgtgt     3720

gcctgatctc tgacttctac cctggggctg tgacagtggc ttggaaggct gatggaagcc     3780

ctgtgaaggc tggggttgag acaacaaagc ccagcaagca gagcaacaac aaatatgctg     3840

ccagcagcta tctgagcctg acacctgagc agtggaagtc ccacagatcc tacagctgtc     3900

aagtgaccca tgagggctcc acagtggaaa agacagtggc ccctacagag tgctcctgat     3960

aactcgagga cggggtgaac tacgcctgag gatccgatct ttttccctct gccaaaaatt     4020

atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg aaatttattt     4080

tcattgcaat agtgtgttgg aattttttgt gtctctca                             4118


<210>  270
<211>  4587
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  270
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg      240

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      300

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      360

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      420

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      480

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      540

cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc      600

ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa      660

ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg      720

cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc      780

gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga      840

agcgcgcggc gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc      900

gcctcgcgcc gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg      960

gacggccctt ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt     1020

ctgtggctgc gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc     1080

tcggggggtg cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc     1140

ggcggctgtg agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag     1200

gggagcgcgg ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc     1260

tgcgtgcggg gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg     1320

caaccccccc tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg     1380

ctccgtacgg ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg     1440

gtgccgggcg gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc     1500

ccccggagcg ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa     1560

tcgtgcgaga gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg     1620

aggcgccgcc gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag     1680

gaaatgggcg gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag     1740

cctcggggct gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc     1800

ggcttctggc gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc     1860

tttttcctac agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa     1920

gaattcgccg ccaccatgta cagaatgcag ctgctgctgc tcattgccct gtctctggcc     1980

ctggtcacca attctcaggt gcagctggtt gaatctggtg gtggtgttgt gcagcctggc     2040

agaagcctga gactgtcttg tgctgcctct ggcttcacct tcagcagctt tggcatgcac     2100

tgggttagac aggcccctgg caaaggcctg gaatgggttg cagtgatcag ctttgatggc     2160

agcatcaagt actctgtgga ctctgtgaag ggcagattca ccatctccag agacaacagc     2220

aagaacaccc tgttcctcca gatgaacagc ctgagagctg aggacacagc agtgtactac     2280

tgtgccagag acaggctgaa ctactatgac agctctggct actaccacta caagtactat     2340

ggcatggctg tgtggggcca gggcaccaca gttacagtgt cctctgccag cacaaagggc     2400

ccctctgttt tccctctggc tccttgctct agaagcacct ctgagtctac agctgccctg     2460

ggctgcctgg tcaaggatta ctttcctgag cctgtgactg tgtcctggaa ctctggtgct     2520

ctgacctctg gggtgcacac ctttccagct gtgctgcagt cctctggcct gtactctctg     2580

tcctctgtgg tcacagtgcc cagctccaat tttggcaccc agacctacac ctgtaatgtg     2640

gaccacaagc ctagcaacac caaggtggac aagactgtgg aaagaaagtg ctgtgtggaa     2700

tgccctcctt gtcctgctcc tccagtggct ggaccctctg tgttcctgtt tcctccaaag     2760

cctaaggaca ccctgatgat cagcagaacc cctgaagtga cctgtgtggt ggtggatgtg     2820

tcccatgagg accctgaggt gcagttcaat tggtatgtgg atggggttga agtgcacaat     2880

gccaagacca agcctagaga ggaacagttc aacagcacct tcagagtggt gtctgtgctg     2940

acagtggtgc atcaggactg gctgaatggc aaagagtaca agtgcaaggt gtccaacaag     3000

ggcctgcctg ctcctattga gaaaaccatc agcaagacca aaggccagcc tagggaaccc     3060

caggtgtaca cactgcctcc aagcagagaa gagatgacca agaaccaggt gtccctgacc     3120

tgtctggtta agggcttcta cccctctgac attgctgtgg aatgggagag caatggccag     3180

ccagagaaca actacaagac cacacctcct atgctggact cagatggctc attcttcctg     3240

tacagcaagc tgactgtgga caagtccagg tggcagcagg gcaatgtgtt cagctgctct     3300

gtgatgcatg aggccctgca caaccactac acccagaagt ctctgtctct gagccctggc     3360

aagagaaaga gaagaggctc tggagaaggc agaggctccc tgctgacatg tggggatgtt     3420

gaagagaatc ctgggcctat gtataggatg caactgctcc tcctgattgc tctgagcctg     3480

gctcttgtga ccaactctca gtctgttctg acccagcctc cttctgtgtc tgctgcccca     3540

ggccagaaag tgaccatcag ctgttctggc agcagcagca acattggcaa caactatgtg     3600

tcttggtatc agcagctccc tggcacagcc cctaaactgc tgatctatga caacaacaag     3660

aggccctctg gcatccctga cagattttct ggctccaagt ctggcaccag caccacactg     3720

ggaatcactg gcctgcagac aggggatgaa gctgactact attgtggcac ctgggacagc     3780

aggctgtctg ctgttgtttt tggtggtggc accaaactga cagtgctggg ccagccaaag     3840

gctaacccca cagtgacact gttccctcca agctctgagg aactgcaggc taacaaggcc     3900

acacttgtgt gcctgatctc tgacttctac cctggggctg tgacagtggc ttggaaggct     3960

gatggaagcc ctgtgaaggc tggggttgag acaacaaagc ccagcaagca gagcaacaac     4020

aaatatgctg ccagcagcta tctgagcctg acacctgagc agtggaagtc ccacagatcc     4080

tacagctgtc aagtgaccca tgagggctcc acagtggaaa agacagtggc ccctacagag     4140

tgctcctgat aactcgagga cggggtgaac tacgcctgag gatccgatct ttttccctct     4200

gccaaaaatt atggggacat catgaagccc cttgagcatc tgacttctgg ctaataaagg     4260

aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctcact cggcggccgc     4320

ccgagtttaa ttggtttata gaactcttca agctagcgaa gcaattcgtt gatctgaatt     4380

tcgaccaccc ataataccca ttaccctggt agataagtag catggcgggt taatcattaa     4440

ctacaaggaa cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac     4500

tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag     4560

cgagcgagcg cgcagcctta attaacc                                         4587


<210>  271
<211>  4057
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  271
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagtc aggtgagtat ctcagggatc cagacatggg gatatgggag     1620

gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttcag aattcgccgc     1680

caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa     1740

ttctcaggtg cagctggttg aatctggtgg tggtgttgtg cagcctggca gaagcctgag     1800

actgtcttgt gctgcctctg gcttcacctt cagcagcttt ggcatgcact gggttagaca     1860

ggcccctggc aaaggcctgg aatgggttgc agtgatcagc tttgatggca gcatcaagta     1920

ctctgtggac tctgtgaagg gcagattcac catctccaga gacaacagca agaacaccct     1980

gttcctccag atgaacagcc tgagagctga ggacacagca gtgtactact gtgccagaga     2040

caggctgaac tactatgaca gctctggcta ctaccactac aagtactatg gcatggctgt     2100

gtggggccag ggcaccacag ttacagtgtc ctctgccagc acaaagggcc cctctgtttt     2160

ccctctggct ccttgctcta gaagcacctc tgagtctaca gctgccctgg gctgcctggt     2220

caaggattac tttcctgagc ctgtgactgt gtcctggaac tctggtgctc tgacctctgg     2280

ggtgcacacc tttccagctg tgctgcagtc ctctggcctg tactctctgt cctctgtggt     2340

cacagtgccc agctccaatt ttggcaccca gacctacacc tgtaatgtgg accacaagcc     2400

tagcaacacc aaggtggaca agactgtgga aagaaagtgc tgtgtggaat gccctccttg     2460

tcctgctcct ccagtggctg gaccctctgt gttcctgttt cctccaaagc ctaaggacac     2520

cctgatgatc agcagaaccc ctgaagtgac ctgtgtggtg gtggatgtgt cccatgagga     2580

ccctgaggtg cagttcaatt ggtatgtgga tggggttgaa gtgcacaatg ccaagaccaa     2640

gcctagagag gaacagttca acagcacctt cagagtggtg tctgtgctga cagtggtgca     2700

tcaggactgg ctgaatggca aagagtacaa gtgcaaggtg tccaacaagg gcctgcctgc     2760

tcctattgag aaaaccatca gcaagaccaa aggccagcct agggaacccc aggtgtacac     2820

actgcctcca agcagagaag agatgaccaa gaaccaggtg tccctgacct gtctggttaa     2880

gggcttctac ccctctgaca ttgctgtgga atgggagagc aatggccagc cagagaacaa     2940

ctacaagacc acacctccta tgctggactc agatggctca ttcttcctgt acagcaagct     3000

gactgtggac aagtccaggt ggcagcaggg caatgtgttc agctgctctg tgatgcatga     3060

ggccctgcac aaccactaca cccagaagtc tctgtctctg agccctggca agagaaagag     3120

aagaggctct ggagaaggca gaggctccct gctgacatgt ggggatgttg aagagaatcc     3180

tgggcctatg tataggatgc aactgctcct cctgattgct ctgagcctgg ctcttgtgac     3240

caactctcag tctgttctga cccagcctcc ttctgtgtct gctgccccag gccagaaagt     3300

gaccatcagc tgttctggca gcagcagcaa cattggcaac aactatgtgt cttggtatca     3360

gcagctccct ggcacagccc ctaaactgct gatctatgac aacaacaaga ggccctctgg     3420

catccctgac agattttctg gctccaagtc tggcaccagc accacactgg gaatcactgg     3480

cctgcagaca ggggatgaag ctgactacta ttgtggcacc tgggacagca ggctgtctgc     3540

tgttgttttt ggtggtggca ccaaactgac agtgctgggc cagccaaagg ctaaccccac     3600

agtgacactg ttccctccaa gctctgagga actgcaggct aacaaggcca cacttgtgtg     3660

cctgatctct gacttctacc ctggggctgt gacagtggct tggaaggctg atggaagccc     3720

tgtgaaggct ggggttgaga caacaaagcc cagcaagcag agcaacaaca aatatgctgc     3780

cagcagctat ctgagcctga cacctgagca gtggaagtcc cacagatcct acagctgtca     3840

agtgacccat gagggctcca cagtggaaaa gacagtggcc cctacagagt gctcctgata     3900

actcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg ccaaaaatta     3960

tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga aatttatttt     4020

cattgcaata gtgtgttgga attttttgtg tctctca                              4057


<210>  272
<211>  4526
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  272
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac      240

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca      300

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca      360

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc      420

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt      480

gtcctggcgt ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag      540

gaggcaaggc ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc      600

cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact      660

acgggtttag gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta      720

taattaaccc agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata      780

accctgtccc tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct      840

ggggacaccc gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc      900

caacacctgc tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc      960

ttcgaacaag gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta     1020

tacgtgcctg ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc     1080

ccccgccagc tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc     1140

agcccataca aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt     1200

gcccgggcaa cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc     1260

tcctggctag tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct     1320

cattctacca ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc     1380

ttgctaccag tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg     1440

gtactctccc agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg     1500

tggtttctga gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc     1560

ccaggcaaag cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc     1620

ccctgtttgc tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc     1680

cgttgcccct ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc     1740

ttcaggcacc accactgacc tgggacagtc aggtgagtat ctcagggatc cagacatggg     1800

gatatgggag gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttcag     1860

aattcgccgc caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc     1920

tggtcaccaa ttctcaggtg cagctggttg aatctggtgg tggtgttgtg cagcctggca     1980

gaagcctgag actgtcttgt gctgcctctg gcttcacctt cagcagcttt ggcatgcact     2040

gggttagaca ggcccctggc aaaggcctgg aatgggttgc agtgatcagc tttgatggca     2100

gcatcaagta ctctgtggac tctgtgaagg gcagattcac catctccaga gacaacagca     2160

agaacaccct gttcctccag atgaacagcc tgagagctga ggacacagca gtgtactact     2220

gtgccagaga caggctgaac tactatgaca gctctggcta ctaccactac aagtactatg     2280

gcatggctgt gtggggccag ggcaccacag ttacagtgtc ctctgccagc acaaagggcc     2340

cctctgtttt ccctctggct ccttgctcta gaagcacctc tgagtctaca gctgccctgg     2400

gctgcctggt caaggattac tttcctgagc ctgtgactgt gtcctggaac tctggtgctc     2460

tgacctctgg ggtgcacacc tttccagctg tgctgcagtc ctctggcctg tactctctgt     2520

cctctgtggt cacagtgccc agctccaatt ttggcaccca gacctacacc tgtaatgtgg     2580

accacaagcc tagcaacacc aaggtggaca agactgtgga aagaaagtgc tgtgtggaat     2640

gccctccttg tcctgctcct ccagtggctg gaccctctgt gttcctgttt cctccaaagc     2700

ctaaggacac cctgatgatc agcagaaccc ctgaagtgac ctgtgtggtg gtggatgtgt     2760

cccatgagga ccctgaggtg cagttcaatt ggtatgtgga tggggttgaa gtgcacaatg     2820

ccaagaccaa gcctagagag gaacagttca acagcacctt cagagtggtg tctgtgctga     2880

cagtggtgca tcaggactgg ctgaatggca aagagtacaa gtgcaaggtg tccaacaagg     2940

gcctgcctgc tcctattgag aaaaccatca gcaagaccaa aggccagcct agggaacccc     3000

aggtgtacac actgcctcca agcagagaag agatgaccaa gaaccaggtg tccctgacct     3060

gtctggttaa gggcttctac ccctctgaca ttgctgtgga atgggagagc aatggccagc     3120

cagagaacaa ctacaagacc acacctccta tgctggactc agatggctca ttcttcctgt     3180

acagcaagct gactgtggac aagtccaggt ggcagcaggg caatgtgttc agctgctctg     3240

tgatgcatga ggccctgcac aaccactaca cccagaagtc tctgtctctg agccctggca     3300

agagaaagag aagaggctct ggagaaggca gaggctccct gctgacatgt ggggatgttg     3360

aagagaatcc tgggcctatg tataggatgc aactgctcct cctgattgct ctgagcctgg     3420

ctcttgtgac caactctcag tctgttctga cccagcctcc ttctgtgtct gctgccccag     3480

gccagaaagt gaccatcagc tgttctggca gcagcagcaa cattggcaac aactatgtgt     3540

cttggtatca gcagctccct ggcacagccc ctaaactgct gatctatgac aacaacaaga     3600

ggccctctgg catccctgac agattttctg gctccaagtc tggcaccagc accacactgg     3660

gaatcactgg cctgcagaca ggggatgaag ctgactacta ttgtggcacc tgggacagca     3720

ggctgtctgc tgttgttttt ggtggtggca ccaaactgac agtgctgggc cagccaaagg     3780

ctaaccccac agtgacactg ttccctccaa gctctgagga actgcaggct aacaaggcca     3840

cacttgtgtg cctgatctct gacttctacc ctggggctgt gacagtggct tggaaggctg     3900

atggaagccc tgtgaaggct ggggttgaga caacaaagcc cagcaagcag agcaacaaca     3960

aatatgctgc cagcagctat ctgagcctga cacctgagca gtggaagtcc cacagatcct     4020

acagctgtca agtgacccat gagggctcca cagtggaaaa gacagtggcc cctacagagt     4080

gctcctgata actcgaggac ggggtgaact acgcctgagg atccgatctt tttccctctg     4140

ccaaaaatta tggggacatc atgaagcccc ttgagcatct gacttctggc taataaagga     4200

aatttatttt cattgcaata gtgtgttgga attttttgtg tctctcactc ggcggccgcc     4260

cgagtttaat tggtttatag aactcttcaa gctagcgaag caattcgttg atctgaattt     4320

cgaccaccca taatacccat taccctggta gataagtagc atggcgggtt aatcattaac     4380

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4440

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4500

gagcgagcgc gcagccttaa ttaacc                                          4526


<210>  273
<211>  3761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  273
taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc tgcctgctga       60

ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg ctcccgtttg      120

acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc ctctcccaga      180

acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct ataaggcgag      240

gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag ctgctaagtt      300

tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca gtgcccagaa      360

aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg gcagggggag      420

gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa gatcttcgaa      480

caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg cttatacgtg      540

cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc tgtcccccgc      600

cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg gggcagccca      660

tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca cggtgcccgg      720

gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag cccctcctgg      780

ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg ccctcattct      840

accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga gatcttgcta      900

ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc      960

tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt     1020

ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc     1080

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt     1140

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc     1200

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg     1260

caccaccact gacctgggac agtcaggtga gtatctcagg gatccagaca tggggatatg     1320

ggaggtgcct ctgatcccag ggctcactgt gggtctctct gttcacaggt tcagaattcg     1380

ccgccaccat gtacagaatg cagctgctgc tgctcattgc cctgtctctg gccctggtca     1440

ccaattctca ggtgcagctg gttgaatctg gtggtggtgt tgtgcagcct ggcagaagcc     1500

tgagactgtc ttgtgctgcc tctggcttca ccttcagcag ctttggcatg cactgggtta     1560

gacaggcccc tggcaaaggc ctggaatggg ttgcagtgat cagctttgat ggcagcatca     1620

agtactctgt ggactctgtg aagggcagat tcaccatctc cagagacaac agcaagaaca     1680

ccctgttcct ccagatgaac agcctgagag ctgaggacac agcagtgtac tactgtgcca     1740

gagacaggct gaactactat gacagctctg gctactacca ctacaagtac tatggcatgg     1800

ctgtgtgggg ccagggcacc acagttacag tgtcctctgc cagcacaaag ggcccctctg     1860

ttttccctct ggctccttgc tctagaagca cctctgagtc tacagctgcc ctgggctgcc     1920

tggtcaagga ttactttcct gagcctgtga ctgtgtcctg gaactctggt gctctgacct     1980

ctggggtgca cacctttcca gctgtgctgc agtcctctgg cctgtactct ctgtcctctg     2040

tggtcacagt gcccagctcc aattttggca cccagaccta cacctgtaat gtggaccaca     2100

agcctagcaa caccaaggtg gacaagactg tggaaagaaa gtgctgtgtg gaatgccctc     2160

cttgtcctgc tcctccagtg gctggaccct ctgtgttcct gtttcctcca aagcctaagg     2220

acaccctgat gatcagcaga acccctgaag tgacctgtgt ggtggtggat gtgtcccatg     2280

aggaccctga ggtgcagttc aattggtatg tggatggggt tgaagtgcac aatgccaaga     2340

ccaagcctag agaggaacag ttcaacagca ccttcagagt ggtgtctgtg ctgacagtgg     2400

tgcatcagga ctggctgaat ggcaaagagt acaagtgcaa ggtgtccaac aagggcctgc     2460

ctgctcctat tgagaaaacc atcagcaaga ccaaaggcca gcctagggaa ccccaggtgt     2520

acacactgcc tccaagcaga gaagagatga ccaagaacca ggtgtccctg acctgtctgg     2580

ttaagggctt ctacccctct gacattgctg tggaatggga gagcaatggc cagccagaga     2640

acaactacaa gaccacacct cctatgctgg actcagatgg ctcattcttc ctgtacagca     2700

agctgactgt ggacaagtcc aggtggcagc agggcaatgt gttcagctgc tctgtgatgc     2760

atgaggccct gcacaaccac tacacccaga agtctctgtc tctgagccct ggcaagagaa     2820

agagaagagg ctctggagaa ggcagaggct ccctgctgac atgtggggat gttgaagaga     2880

atcctgggcc tatgtatagg atgcaactgc tcctcctgat tgctctgagc ctggctcttg     2940

tgaccaactc tcagtctgtt ctgacccagc ctccttctgt gtctgctgcc ccaggccaga     3000

aagtgaccat cagctgttct ggcagcagca gcaacattgg caacaactat gtgtcttggt     3060

atcagcagct ccctggcaca gcccctaaac tgctgatcta tgacaacaac aagaggccct     3120

ctggcatccc tgacagattt tctggctcca agtctggcac cagcaccaca ctgggaatca     3180

ctggcctgca gacaggggat gaagctgact actattgtgg cacctgggac agcaggctgt     3240

ctgctgttgt ttttggtggt ggcaccaaac tgacagtgct gggccagcca aaggctaacc     3300

ccacagtgac actgttccct ccaagctctg aggaactgca ggctaacaag gccacacttg     3360

tgtgcctgat ctctgacttc taccctgggg ctgtgacagt ggcttggaag gctgatggaa     3420

gccctgtgaa ggctggggtt gagacaacaa agcccagcaa gcagagcaac aacaaatatg     3480

ctgccagcag ctatctgagc ctgacacctg agcagtggaa gtcccacaga tcctacagct     3540

gtcaagtgac ccatgagggc tccacagtgg aaaagacagt ggcccctaca gagtgctcct     3600

gataactcga ggacggggtg aactacgcct gaggatccga tctttttccc tctgccaaaa     3660

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3720

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc a                         3761


<210>  274
<211>  4230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  274
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      240

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg      300

ctcccgtttg acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc      360

ctctcccaga acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct      420

ataaggcgag gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag      480

ctgctaagtt tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca      540

gtgcccagaa aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg      600

gcagggggag gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa      660

gatcttcgaa caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg      720

cttatacgtg cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc      780

tgtcccccgc cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg      840

gggcagccca tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca      900

cggtgcccgg gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag      960

cccctcctgg ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg     1020

ccctcattct accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga     1080

gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta     1140

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac     1200

gctgtggttt ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca     1260

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact     1320

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct     1380

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct     1440

cagcttcagg caccaccact gacctgggac agtcaggtga gtatctcagg gatccagaca     1500

tggggatatg ggaggtgcct ctgatcccag ggctcactgt gggtctctct gttcacaggt     1560

tcagaattcg ccgccaccat gtacagaatg cagctgctgc tgctcattgc cctgtctctg     1620

gccctggtca ccaattctca ggtgcagctg gttgaatctg gtggtggtgt tgtgcagcct     1680

ggcagaagcc tgagactgtc ttgtgctgcc tctggcttca ccttcagcag ctttggcatg     1740

cactgggtta gacaggcccc tggcaaaggc ctggaatggg ttgcagtgat cagctttgat     1800

ggcagcatca agtactctgt ggactctgtg aagggcagat tcaccatctc cagagacaac     1860

agcaagaaca ccctgttcct ccagatgaac agcctgagag ctgaggacac agcagtgtac     1920

tactgtgcca gagacaggct gaactactat gacagctctg gctactacca ctacaagtac     1980

tatggcatgg ctgtgtgggg ccagggcacc acagttacag tgtcctctgc cagcacaaag     2040

ggcccctctg ttttccctct ggctccttgc tctagaagca cctctgagtc tacagctgcc     2100

ctgggctgcc tggtcaagga ttactttcct gagcctgtga ctgtgtcctg gaactctggt     2160

gctctgacct ctggggtgca cacctttcca gctgtgctgc agtcctctgg cctgtactct     2220

ctgtcctctg tggtcacagt gcccagctcc aattttggca cccagaccta cacctgtaat     2280

gtggaccaca agcctagcaa caccaaggtg gacaagactg tggaaagaaa gtgctgtgtg     2340

gaatgccctc cttgtcctgc tcctccagtg gctggaccct ctgtgttcct gtttcctcca     2400

aagcctaagg acaccctgat gatcagcaga acccctgaag tgacctgtgt ggtggtggat     2460

gtgtcccatg aggaccctga ggtgcagttc aattggtatg tggatggggt tgaagtgcac     2520

aatgccaaga ccaagcctag agaggaacag ttcaacagca ccttcagagt ggtgtctgtg     2580

ctgacagtgg tgcatcagga ctggctgaat ggcaaagagt acaagtgcaa ggtgtccaac     2640

aagggcctgc ctgctcctat tgagaaaacc atcagcaaga ccaaaggcca gcctagggaa     2700

ccccaggtgt acacactgcc tccaagcaga gaagagatga ccaagaacca ggtgtccctg     2760

acctgtctgg ttaagggctt ctacccctct gacattgctg tggaatggga gagcaatggc     2820

cagccagaga acaactacaa gaccacacct cctatgctgg actcagatgg ctcattcttc     2880

ctgtacagca agctgactgt ggacaagtcc aggtggcagc agggcaatgt gttcagctgc     2940

tctgtgatgc atgaggccct gcacaaccac tacacccaga agtctctgtc tctgagccct     3000

ggcaagagaa agagaagagg ctctggagaa ggcagaggct ccctgctgac atgtggggat     3060

gttgaagaga atcctgggcc tatgtatagg atgcaactgc tcctcctgat tgctctgagc     3120

ctggctcttg tgaccaactc tcagtctgtt ctgacccagc ctccttctgt gtctgctgcc     3180

ccaggccaga aagtgaccat cagctgttct ggcagcagca gcaacattgg caacaactat     3240

gtgtcttggt atcagcagct ccctggcaca gcccctaaac tgctgatcta tgacaacaac     3300

aagaggccct ctggcatccc tgacagattt tctggctcca agtctggcac cagcaccaca     3360

ctgggaatca ctggcctgca gacaggggat gaagctgact actattgtgg cacctgggac     3420

agcaggctgt ctgctgttgt ttttggtggt ggcaccaaac tgacagtgct gggccagcca     3480

aaggctaacc ccacagtgac actgttccct ccaagctctg aggaactgca ggctaacaag     3540

gccacacttg tgtgcctgat ctctgacttc taccctgggg ctgtgacagt ggcttggaag     3600

gctgatggaa gccctgtgaa ggctggggtt gagacaacaa agcccagcaa gcagagcaac     3660

aacaaatatg ctgccagcag ctatctgagc ctgacacctg agcagtggaa gtcccacaga     3720

tcctacagct gtcaagtgac ccatgagggc tccacagtgg aaaagacagt ggcccctaca     3780

gagtgctcct gataactcga ggacggggtg aactacgcct gaggatccga tctttttccc     3840

tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa     3900

aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggcggc     3960

cgcccgagtt taattggttt atagaactct tcaagctagc gaagcaattc gttgatctga     4020

atttcgacca cccataatac ccattaccct ggtagataag tagcatggcg ggttaatcat     4080

taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     4140

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     4200

gagcgagcga gcgcgcagcc ttaattaacc                                      4230


<210>  275
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  275
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtggaatc tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg tgtctggcat tgacctgtct ggctactaca tgaactgggt cagacaggcc      180

cctggcaaag gcctggaatg ggttggagtg attggcatca atggggccac ctactatgcc      240

agctgggcca agggcagatt caccatcagc agagacaaca gcaagaccac agtgtacctg      300

cagatgaact ccctgagagc tgaggataca gctgtgtact tctgtgccag aggggatatc      360

tggggccagg gcacactggt tacagtgtcc tctgccagca caaagggccc ctctgttttt      420

ccactggctc ccagcagcaa gagcaccagt ggtggaacag ctgccctggg ctgtctggtc      480

aaggattact tccctgagcc tgtgactgtg tcctggaact ctggtgcact gacctctggg      540

gtgcacacct ttccagctgt gctgcagtcc tctggcctgt actctctgtc ctctgtggtc      600

acagtgccta gctctagcct gggcacccag acctacatct gcaatgtgaa ccacaagcct      660

agcaacacca aagtggatgc cagagtggaa cccaagagct gtgacaagac ccacacctgt      720

cctccatgtc ctgctccaga actgcttgga ggcccttctg tgttcctgtt tcctccaaag      780

cctaaggaca ccctgatgat cagcagaacc cctgaagtga cctgtgtggt ggttgatgtg      840

tcccatgagg acccagaagt gaagttcaat tggtatgtgg atggggttga agtgcacaat      900

gccaagacca agcctaggga agaacagtat gccagcacct acagagtggt gtctgtgctg      960

acagtgctgc accaggactg gctgaatggc aaagagtaca agtgcaaggt gtccaacaag     1020

gccctgcctg ctcctattga gaaaaccatc tccaaggcca aggggcagcc cagagaacct     1080

caggtttaca ccctgccacc tagcagagaa gagatgacca agaaccaggt gtccctgacc     1140

tgcctggtta agggcttcta cccctctgac attgctgtgg aatgggagag caatggccag     1200

ccagagaaca actacaagac aacccctcct gtgctggact ctgatggctc attcttcctg     1260

tacagcaagc tgactgtgga caagagcaga tggcagcagg gcaatgtgtt cagctgctct     1320

gtgatgcatg aggccctgca caaccactac acccagaaaa gcctgtctct gagccctggc     1380

aagagaaaga gaagaggctc tggagaaggc agaggctccc tgctgacatg tggggatgtt     1440

gaagagaatc ctgggcctat gtataggatg caactgctcc tcctgattgc tctgagcctg     1500

gctcttgtga ccaactctca ggttctgaca cagagcccta gcagcctgtc tgcttctgtg     1560

ggagacagag tgaccatcaa ctgccaggcc tctcagtctg tgtaccacaa cacctacctg     1620

gcctggtatc agcaaaagcc tggcaaggtg cccaagcagc tgatctatga tgcctctaca     1680

ctggcatcag gggtgccctc cagattttct ggctctggat ctggcactga cttcaccctg     1740

accatcagta gcctgcagcc tgaagatgtg gccacctatt actgcctggg cagctatgac     1800

tgcaccaatg gggactgctt tgtgtttggt ggtggcacca aggtggaaat caagagaaca     1860

gtggctgccc catctgtgtt catcttccca ccatctgatg aacagctgaa gagtggcaca     1920

gcctctgttg tgtgcctgct gaacaacttc taccctagag aagccaaggt gcagtggaag     1980

gtggacaatg ccctgcagtc tggcaacagc caagaatctg tgacagagca ggactccaag     2040

gattccacct acagcctgag cagcaccctg acactgagca aggctgacta tgagaagcac     2100

aaagtgtatg cctgtgaagt gacacaccag ggactgagca gcccagtgac caagagcttc     2160

aacaggggag agtgctga                                                   2178


<210>  276
<211>  2118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  276
gaagtgcagc tggtggaatc tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg tgtctggcat tgacctgtct ggctactaca tgaactgggt cagacaggcc      120

cctggcaaag gcctggaatg ggttggagtg attggcatca atggggccac ctactatgcc      180

agctgggcca agggcagatt caccatcagc agagacaaca gcaagaccac agtgtacctg      240

cagatgaact ccctgagagc tgaggataca gctgtgtact tctgtgccag aggggatatc      300

tggggccagg gcacactggt tacagtgtcc tctgccagca caaagggccc ctctgttttt      360

ccactggctc ccagcagcaa gagcaccagt ggtggaacag ctgccctggg ctgtctggtc      420

aaggattact tccctgagcc tgtgactgtg tcctggaact ctggtgcact gacctctggg      480

gtgcacacct ttccagctgt gctgcagtcc tctggcctgt actctctgtc ctctgtggtc      540

acagtgccta gctctagcct gggcacccag acctacatct gcaatgtgaa ccacaagcct      600

agcaacacca aagtggatgc cagagtggaa cccaagagct gtgacaagac ccacacctgt      660

cctccatgtc ctgctccaga actgcttgga ggcccttctg tgttcctgtt tcctccaaag      720

cctaaggaca ccctgatgat cagcagaacc cctgaagtga cctgtgtggt ggttgatgtg      780

tcccatgagg acccagaagt gaagttcaat tggtatgtgg atggggttga agtgcacaat      840

gccaagacca agcctaggga agaacagtat gccagcacct acagagtggt gtctgtgctg      900

acagtgctgc accaggactg gctgaatggc aaagagtaca agtgcaaggt gtccaacaag      960

gccctgcctg ctcctattga gaaaaccatc tccaaggcca aggggcagcc cagagaacct     1020

caggtttaca ccctgccacc tagcagagaa gagatgacca agaaccaggt gtccctgacc     1080

tgcctggtta agggcttcta cccctctgac attgctgtgg aatgggagag caatggccag     1140

ccagagaaca actacaagac aacccctcct gtgctggact ctgatggctc attcttcctg     1200

tacagcaagc tgactgtgga caagagcaga tggcagcagg gcaatgtgtt cagctgctct     1260

gtgatgcatg aggccctgca caaccactac acccagaaaa gcctgtctct gagccctggc     1320

aagagaaaga gaagaggctc tggagaaggc agaggctccc tgctgacatg tggggatgtt     1380

gaagagaatc ctgggcctat gtataggatg caactgctcc tcctgattgc tctgagcctg     1440

gctcttgtga ccaactctca ggttctgaca cagagcccta gcagcctgtc tgcttctgtg     1500

ggagacagag tgaccatcaa ctgccaggcc tctcagtctg tgtaccacaa cacctacctg     1560

gcctggtatc agcaaaagcc tggcaaggtg cccaagcagc tgatctatga tgcctctaca     1620

ctggcatcag gggtgccctc cagattttct ggctctggat ctggcactga cttcaccctg     1680

accatcagta gcctgcagcc tgaagatgtg gccacctatt actgcctggg cagctatgac     1740

tgcaccaatg gggactgctt tgtgtttggt ggtggcacca aggtggaaat caagagaaca     1800

gtggctgccc catctgtgtt catcttccca ccatctgatg aacagctgaa gagtggcaca     1860

gcctctgttg tgtgcctgct gaacaacttc taccctagag aagccaaggt gcagtggaag     1920

gtggacaatg ccctgcagtc tggcaacagc caagaatctg tgacagagca ggactccaag     1980

gattccacct acagcctgag cagcaccctg acactgagca aggctgacta tgagaagcac     2040

aaagtgtatg cctgtgaagt gacacaccag ggactgagca gcccagtgac caagagcttc     2100

aacaggggag agtgctga                                                   2118


<210>  277
<211>  4082
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  277
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcgccg     1740

ccaccatgta cagaatgcag ctgctgctgc tcattgccct gtctctggcc ctggtcacca     1800

attctgaagt gcagctggtg gaatctggtg gtggactggt tcagcctggt ggcagcctga     1860

gactgtcttg tgctgtgtct ggcattgacc tgtctggcta ctacatgaac tgggtcagac     1920

aggcccctgg caaaggcctg gaatgggttg gagtgattgg catcaatggg gccacctact     1980

atgccagctg ggccaagggc agattcacca tcagcagaga caacagcaag accacagtgt     2040

acctgcagat gaactccctg agagctgagg atacagctgt gtacttctgt gccagagggg     2100

atatctgggg ccagggcaca ctggttacag tgtcctctgc cagcacaaag ggcccctctg     2160

tttttccact ggctcccagc agcaagagca ccagtggtgg aacagctgcc ctgggctgtc     2220

tggtcaagga ttacttccct gagcctgtga ctgtgtcctg gaactctggt gcactgacct     2280

ctggggtgca cacctttcca gctgtgctgc agtcctctgg cctgtactct ctgtcctctg     2340

tggtcacagt gcctagctct agcctgggca cccagaccta catctgcaat gtgaaccaca     2400

agcctagcaa caccaaagtg gatgccagag tggaacccaa gagctgtgac aagacccaca     2460

cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc ctgtttcctc     2520

caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt gtggtggttg     2580

atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg gttgaagtgc     2640

acaatgccaa gaccaagcct agggaagaac agtatgccag cacctacaga gtggtgtctg     2700

tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc aaggtgtcca     2760

acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggg cagcccagag     2820

aacctcaggt ttacaccctg ccacctagca gagaagagat gaccaagaac caggtgtccc     2880

tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg gagagcaatg     2940

gccagccaga gaacaactac aagacaaccc ctcctgtgct ggactctgat ggctcattct     3000

tcctgtacag caagctgact gtggacaaga gcagatggca gcagggcaat gtgttcagct     3060

gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagcctg tctctgagcc     3120

ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg acatgtgggg     3180

atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg attgctctga     3240

gcctggctct tgtgaccaac tctcaggttc tgacacagag ccctagcagc ctgtctgctt     3300

ctgtgggaga cagagtgacc atcaactgcc aggcctctca gtctgtgtac cacaacacct     3360

acctggcctg gtatcagcaa aagcctggca aggtgcccaa gcagctgatc tatgatgcct     3420

ctacactggc atcaggggtg ccctccagat tttctggctc tggatctggc actgacttca     3480

ccctgaccat cagtagcctg cagcctgaag atgtggccac ctattactgc ctgggcagct     3540

atgactgcac caatggggac tgctttgtgt ttggtggtgg caccaaggtg gaaatcaaga     3600

gaacagtggc tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagagtg     3660

gcacagcctc tgttgtgtgc ctgctgaaca acttctaccc tagagaagcc aaggtgcagt     3720

ggaaggtgga caatgccctg cagtctggca acagccaaga atctgtgaca gagcaggact     3780

ccaaggattc cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga     3840

agcacaaagt gtatgcctgt gaagtgacac accagggact gagcagccca gtgaccaaga     3900

gcttcaacag gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg     3960

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     4020

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     4080

ca                                                                    4082


<210>  278
<211>  4551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  278
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg      240

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      300

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      360

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      420

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      480

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      540

cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc      600

ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa      660

ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg      720

cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc      780

gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga      840

agcgcgcggc gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc      900

gcctcgcgcc gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg      960

gacggccctt ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt     1020

ctgtggctgc gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc     1080

tcggggggtg cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc     1140

ggcggctgtg agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag     1200

gggagcgcgg ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc     1260

tgcgtgcggg gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg     1320

caaccccccc tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg     1380

ctccgtacgg ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg     1440

gtgccgggcg gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc     1500

ccccggagcg ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa     1560

tcgtgcgaga gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg     1620

aggcgccgcc gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag     1680

gaaatgggcg gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag     1740

cctcggggct gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc     1800

ggcttctggc gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc     1860

tttttcctac agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa     1920

gaattcgccg ccaccatgta cagaatgcag ctgctgctgc tcattgccct gtctctggcc     1980

ctggtcacca attctgaagt gcagctggtg gaatctggtg gtggactggt tcagcctggt     2040

ggcagcctga gactgtcttg tgctgtgtct ggcattgacc tgtctggcta ctacatgaac     2100

tgggtcagac aggcccctgg caaaggcctg gaatgggttg gagtgattgg catcaatggg     2160

gccacctact atgccagctg ggccaagggc agattcacca tcagcagaga caacagcaag     2220

accacagtgt acctgcagat gaactccctg agagctgagg atacagctgt gtacttctgt     2280

gccagagggg atatctgggg ccagggcaca ctggttacag tgtcctctgc cagcacaaag     2340

ggcccctctg tttttccact ggctcccagc agcaagagca ccagtggtgg aacagctgcc     2400

ctgggctgtc tggtcaagga ttacttccct gagcctgtga ctgtgtcctg gaactctggt     2460

gcactgacct ctggggtgca cacctttcca gctgtgctgc agtcctctgg cctgtactct     2520

ctgtcctctg tggtcacagt gcctagctct agcctgggca cccagaccta catctgcaat     2580

gtgaaccaca agcctagcaa caccaaagtg gatgccagag tggaacccaa gagctgtgac     2640

aagacccaca cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc     2700

ctgtttcctc caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt     2760

gtggtggttg atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg     2820

gttgaagtgc acaatgccaa gaccaagcct agggaagaac agtatgccag cacctacaga     2880

gtggtgtctg tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc     2940

aaggtgtcca acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggg     3000

cagcccagag aacctcaggt ttacaccctg ccacctagca gagaagagat gaccaagaac     3060

caggtgtccc tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg     3120

gagagcaatg gccagccaga gaacaactac aagacaaccc ctcctgtgct ggactctgat     3180

ggctcattct tcctgtacag caagctgact gtggacaaga gcagatggca gcagggcaat     3240

gtgttcagct gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagcctg     3300

tctctgagcc ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg     3360

acatgtgggg atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg     3420

attgctctga gcctggctct tgtgaccaac tctcaggttc tgacacagag ccctagcagc     3480

ctgtctgctt ctgtgggaga cagagtgacc atcaactgcc aggcctctca gtctgtgtac     3540

cacaacacct acctggcctg gtatcagcaa aagcctggca aggtgcccaa gcagctgatc     3600

tatgatgcct ctacactggc atcaggggtg ccctccagat tttctggctc tggatctggc     3660

actgacttca ccctgaccat cagtagcctg cagcctgaag atgtggccac ctattactgc     3720

ctgggcagct atgactgcac caatggggac tgctttgtgt ttggtggtgg caccaaggtg     3780

gaaatcaaga gaacagtggc tgccccatct gtgttcatct tcccaccatc tgatgaacag     3840

ctgaagagtg gcacagcctc tgttgtgtgc ctgctgaaca acttctaccc tagagaagcc     3900

aaggtgcagt ggaaggtgga caatgccctg cagtctggca acagccaaga atctgtgaca     3960

gagcaggact ccaaggattc cacctacagc ctgagcagca ccctgacact gagcaaggct     4020

gactatgaga agcacaaagt gtatgcctgt gaagtgacac accagggact gagcagccca     4080

gtgaccaaga gcttcaacag gggagagtgc tgataactcg aggacggggt gaactacgcc     4140

tgaggatccg atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     4200

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     4260

ttgtgtctct cactcggcgg ccgcccgagt ttaattggtt tatagaactc ttcaagctag     4320

cgaagcaatt cgttgatctg aatttcgacc acccataata cccattaccc tggtagataa     4380

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     4440

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4500

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc cttaattaac c              4551


<210>  279
<211>  4021
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  279
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagtc aggtgagtat ctcagggatc cagacatggg gatatgggag     1620

gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttcag aattcgccgc     1680

caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa     1740

ttctgaagtg cagctggtgg aatctggtgg tggactggtt cagcctggtg gcagcctgag     1800

actgtcttgt gctgtgtctg gcattgacct gtctggctac tacatgaact gggtcagaca     1860

ggcccctggc aaaggcctgg aatgggttgg agtgattggc atcaatgggg ccacctacta     1920

tgccagctgg gccaagggca gattcaccat cagcagagac aacagcaaga ccacagtgta     1980

cctgcagatg aactccctga gagctgagga tacagctgtg tacttctgtg ccagagggga     2040

tatctggggc cagggcacac tggttacagt gtcctctgcc agcacaaagg gcccctctgt     2100

ttttccactg gctcccagca gcaagagcac cagtggtgga acagctgccc tgggctgtct     2160

ggtcaaggat tacttccctg agcctgtgac tgtgtcctgg aactctggtg cactgacctc     2220

tggggtgcac acctttccag ctgtgctgca gtcctctggc ctgtactctc tgtcctctgt     2280

ggtcacagtg cctagctcta gcctgggcac ccagacctac atctgcaatg tgaaccacaa     2340

gcctagcaac accaaagtgg atgccagagt ggaacccaag agctgtgaca agacccacac     2400

ctgtcctcca tgtcctgctc cagaactgct tggaggccct tctgtgttcc tgtttcctcc     2460

aaagcctaag gacaccctga tgatcagcag aacccctgaa gtgacctgtg tggtggttga     2520

tgtgtcccat gaggacccag aagtgaagtt caattggtat gtggatgggg ttgaagtgca     2580

caatgccaag accaagccta gggaagaaca gtatgccagc acctacagag tggtgtctgt     2640

gctgacagtg ctgcaccagg actggctgaa tggcaaagag tacaagtgca aggtgtccaa     2700

caaggccctg cctgctccta ttgagaaaac catctccaag gccaaggggc agcccagaga     2760

acctcaggtt tacaccctgc cacctagcag agaagagatg accaagaacc aggtgtccct     2820

gacctgcctg gttaagggct tctacccctc tgacattgct gtggaatggg agagcaatgg     2880

ccagccagag aacaactaca agacaacccc tcctgtgctg gactctgatg gctcattctt     2940

cctgtacagc aagctgactg tggacaagag cagatggcag cagggcaatg tgttcagctg     3000

ctctgtgatg catgaggccc tgcacaacca ctacacccag aaaagcctgt ctctgagccc     3060

tggcaagaga aagagaagag gctctggaga aggcagaggc tccctgctga catgtgggga     3120

tgttgaagag aatcctgggc ctatgtatag gatgcaactg ctcctcctga ttgctctgag     3180

cctggctctt gtgaccaact ctcaggttct gacacagagc cctagcagcc tgtctgcttc     3240

tgtgggagac agagtgacca tcaactgcca ggcctctcag tctgtgtacc acaacaccta     3300

cctggcctgg tatcagcaaa agcctggcaa ggtgcccaag cagctgatct atgatgcctc     3360

tacactggca tcaggggtgc cctccagatt ttctggctct ggatctggca ctgacttcac     3420

cctgaccatc agtagcctgc agcctgaaga tgtggccacc tattactgcc tgggcagcta     3480

tgactgcacc aatggggact gctttgtgtt tggtggtggc accaaggtgg aaatcaagag     3540

aacagtggct gccccatctg tgttcatctt cccaccatct gatgaacagc tgaagagtgg     3600

cacagcctct gttgtgtgcc tgctgaacaa cttctaccct agagaagcca aggtgcagtg     3660

gaaggtggac aatgccctgc agtctggcaa cagccaagaa tctgtgacag agcaggactc     3720

caaggattcc acctacagcc tgagcagcac cctgacactg agcaaggctg actatgagaa     3780

gcacaaagtg tatgcctgtg aagtgacaca ccagggactg agcagcccag tgaccaagag     3840

cttcaacagg ggagagtgct gataactcga ggacggggtg aactacgcct gaggatccga     3900

tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc     3960

tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc     4020

a                                                                     4021


<210>  280
<211>  4490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  280
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac      240

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca      300

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca      360

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc      420

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt      480

gtcctggcgt ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag      540

gaggcaaggc ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc      600

cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact      660

acgggtttag gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta      720

taattaaccc agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata      780

accctgtccc tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct      840

ggggacaccc gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc      900

caacacctgc tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc      960

ttcgaacaag gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta     1020

tacgtgcctg ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc     1080

ccccgccagc tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc     1140

agcccataca aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt     1200

gcccgggcaa cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc     1260

tcctggctag tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct     1320

cattctacca ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc     1380

ttgctaccag tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg     1440

gtactctccc agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg     1500

tggtttctga gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc     1560

ccaggcaaag cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc     1620

ccctgtttgc tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc     1680

cgttgcccct ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc     1740

ttcaggcacc accactgacc tgggacagtc aggtgagtat ctcagggatc cagacatggg     1800

gatatgggag gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttcag     1860

aattcgccgc caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc     1920

tggtcaccaa ttctgaagtg cagctggtgg aatctggtgg tggactggtt cagcctggtg     1980

gcagcctgag actgtcttgt gctgtgtctg gcattgacct gtctggctac tacatgaact     2040

gggtcagaca ggcccctggc aaaggcctgg aatgggttgg agtgattggc atcaatgggg     2100

ccacctacta tgccagctgg gccaagggca gattcaccat cagcagagac aacagcaaga     2160

ccacagtgta cctgcagatg aactccctga gagctgagga tacagctgtg tacttctgtg     2220

ccagagggga tatctggggc cagggcacac tggttacagt gtcctctgcc agcacaaagg     2280

gcccctctgt ttttccactg gctcccagca gcaagagcac cagtggtgga acagctgccc     2340

tgggctgtct ggtcaaggat tacttccctg agcctgtgac tgtgtcctgg aactctggtg     2400

cactgacctc tggggtgcac acctttccag ctgtgctgca gtcctctggc ctgtactctc     2460

tgtcctctgt ggtcacagtg cctagctcta gcctgggcac ccagacctac atctgcaatg     2520

tgaaccacaa gcctagcaac accaaagtgg atgccagagt ggaacccaag agctgtgaca     2580

agacccacac ctgtcctcca tgtcctgctc cagaactgct tggaggccct tctgtgttcc     2640

tgtttcctcc aaagcctaag gacaccctga tgatcagcag aacccctgaa gtgacctgtg     2700

tggtggttga tgtgtcccat gaggacccag aagtgaagtt caattggtat gtggatgggg     2760

ttgaagtgca caatgccaag accaagccta gggaagaaca gtatgccagc acctacagag     2820

tggtgtctgt gctgacagtg ctgcaccagg actggctgaa tggcaaagag tacaagtgca     2880

aggtgtccaa caaggccctg cctgctccta ttgagaaaac catctccaag gccaaggggc     2940

agcccagaga acctcaggtt tacaccctgc cacctagcag agaagagatg accaagaacc     3000

aggtgtccct gacctgcctg gttaagggct tctacccctc tgacattgct gtggaatggg     3060

agagcaatgg ccagccagag aacaactaca agacaacccc tcctgtgctg gactctgatg     3120

gctcattctt cctgtacagc aagctgactg tggacaagag cagatggcag cagggcaatg     3180

tgttcagctg ctctgtgatg catgaggccc tgcacaacca ctacacccag aaaagcctgt     3240

ctctgagccc tggcaagaga aagagaagag gctctggaga aggcagaggc tccctgctga     3300

catgtgggga tgttgaagag aatcctgggc ctatgtatag gatgcaactg ctcctcctga     3360

ttgctctgag cctggctctt gtgaccaact ctcaggttct gacacagagc cctagcagcc     3420

tgtctgcttc tgtgggagac agagtgacca tcaactgcca ggcctctcag tctgtgtacc     3480

acaacaccta cctggcctgg tatcagcaaa agcctggcaa ggtgcccaag cagctgatct     3540

atgatgcctc tacactggca tcaggggtgc cctccagatt ttctggctct ggatctggca     3600

ctgacttcac cctgaccatc agtagcctgc agcctgaaga tgtggccacc tattactgcc     3660

tgggcagcta tgactgcacc aatggggact gctttgtgtt tggtggtggc accaaggtgg     3720

aaatcaagag aacagtggct gccccatctg tgttcatctt cccaccatct gatgaacagc     3780

tgaagagtgg cacagcctct gttgtgtgcc tgctgaacaa cttctaccct agagaagcca     3840

aggtgcagtg gaaggtggac aatgccctgc agtctggcaa cagccaagaa tctgtgacag     3900

agcaggactc caaggattcc acctacagcc tgagcagcac cctgacactg agcaaggctg     3960

actatgagaa gcacaaagtg tatgcctgtg aagtgacaca ccagggactg agcagcccag     4020

tgaccaagag cttcaacagg ggagagtgct gataactcga ggacggggtg aactacgcct     4080

gaggatccga tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc     4140

atctgacttc tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt     4200

tgtgtctctc actcggcggc cgcccgagtt taattggttt atagaactct tcaagctagc     4260

gaagcaattc gttgatctga atttcgacca cccataatac ccattaccct ggtagataag     4320

tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc     4380

tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc     4440

tttgcccggg cggcctcagt gagcgagcga gcgcgcagcc ttaattaacc                4490


<210>  281
<211>  3725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  281
taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc tgcctgctga       60

ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg ctcccgtttg      120

acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc ctctcccaga      180

acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct ataaggcgag      240

gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag ctgctaagtt      300

tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca gtgcccagaa      360

aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg gcagggggag      420

gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa gatcttcgaa      480

caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg cttatacgtg      540

cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc tgtcccccgc      600

cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg gggcagccca      660

tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca cggtgcccgg      720

gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag cccctcctgg      780

ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg ccctcattct      840

accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga gatcttgcta      900

ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc      960

tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt     1020

ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc     1080

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt     1140

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc     1200

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg     1260

caccaccact gacctgggac agtcaggtga gtatctcagg gatccagaca tggggatatg     1320

ggaggtgcct ctgatcccag ggctcactgt gggtctctct gttcacaggt tcagaattcg     1380

ccgccaccat gtacagaatg cagctgctgc tgctcattgc cctgtctctg gccctggtca     1440

ccaattctga agtgcagctg gtggaatctg gtggtggact ggttcagcct ggtggcagcc     1500

tgagactgtc ttgtgctgtg tctggcattg acctgtctgg ctactacatg aactgggtca     1560

gacaggcccc tggcaaaggc ctggaatggg ttggagtgat tggcatcaat ggggccacct     1620

actatgccag ctgggccaag ggcagattca ccatcagcag agacaacagc aagaccacag     1680

tgtacctgca gatgaactcc ctgagagctg aggatacagc tgtgtacttc tgtgccagag     1740

gggatatctg gggccagggc acactggtta cagtgtcctc tgccagcaca aagggcccct     1800

ctgtttttcc actggctccc agcagcaaga gcaccagtgg tggaacagct gccctgggct     1860

gtctggtcaa ggattacttc cctgagcctg tgactgtgtc ctggaactct ggtgcactga     1920

cctctggggt gcacaccttt ccagctgtgc tgcagtcctc tggcctgtac tctctgtcct     1980

ctgtggtcac agtgcctagc tctagcctgg gcacccagac ctacatctgc aatgtgaacc     2040

acaagcctag caacaccaaa gtggatgcca gagtggaacc caagagctgt gacaagaccc     2100

acacctgtcc tccatgtcct gctccagaac tgcttggagg cccttctgtg ttcctgtttc     2160

ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc tgtgtggtgg     2220

ttgatgtgtc ccatgaggac ccagaagtga agttcaattg gtatgtggat ggggttgaag     2280

tgcacaatgc caagaccaag cctagggaag aacagtatgc cagcacctac agagtggtgt     2340

ctgtgctgac agtgctgcac caggactggc tgaatggcaa agagtacaag tgcaaggtgt     2400

ccaacaaggc cctgcctgct cctattgaga aaaccatctc caaggccaag gggcagccca     2460

gagaacctca ggtttacacc ctgccaccta gcagagaaga gatgaccaag aaccaggtgt     2520

ccctgacctg cctggttaag ggcttctacc cctctgacat tgctgtggaa tgggagagca     2580

atggccagcc agagaacaac tacaagacaa cccctcctgt gctggactct gatggctcat     2640

tcttcctgta cagcaagctg actgtggaca agagcagatg gcagcagggc aatgtgttca     2700

gctgctctgt gatgcatgag gccctgcaca accactacac ccagaaaagc ctgtctctga     2760

gccctggcaa gagaaagaga agaggctctg gagaaggcag aggctccctg ctgacatgtg     2820

gggatgttga agagaatcct gggcctatgt ataggatgca actgctcctc ctgattgctc     2880

tgagcctggc tcttgtgacc aactctcagg ttctgacaca gagccctagc agcctgtctg     2940

cttctgtggg agacagagtg accatcaact gccaggcctc tcagtctgtg taccacaaca     3000

cctacctggc ctggtatcag caaaagcctg gcaaggtgcc caagcagctg atctatgatg     3060

cctctacact ggcatcaggg gtgccctcca gattttctgg ctctggatct ggcactgact     3120

tcaccctgac catcagtagc ctgcagcctg aagatgtggc cacctattac tgcctgggca     3180

gctatgactg caccaatggg gactgctttg tgtttggtgg tggcaccaag gtggaaatca     3240

agagaacagt ggctgcccca tctgtgttca tcttcccacc atctgatgaa cagctgaaga     3300

gtggcacagc ctctgttgtg tgcctgctga acaacttcta ccctagagaa gccaaggtgc     3360

agtggaaggt ggacaatgcc ctgcagtctg gcaacagcca agaatctgtg acagagcagg     3420

actccaagga ttccacctac agcctgagca gcaccctgac actgagcaag gctgactatg     3480

agaagcacaa agtgtatgcc tgtgaagtga cacaccaggg actgagcagc ccagtgacca     3540

agagcttcaa caggggagag tgctgataac tcgaggacgg ggtgaactac gcctgaggat     3600

ccgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt gagcatctga     3660

cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc     3720

tctca                                                                 3725


<210>  282
<211>  4194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  282
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      240

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg      300

ctcccgtttg acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc      360

ctctcccaga acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct      420

ataaggcgag gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag      480

ctgctaagtt tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca      540

gtgcccagaa aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg      600

gcagggggag gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa      660

gatcttcgaa caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg      720

cttatacgtg cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc      780

tgtcccccgc cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg      840

gggcagccca tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca      900

cggtgcccgg gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag      960

cccctcctgg ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg     1020

ccctcattct accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga     1080

gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta     1140

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac     1200

gctgtggttt ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca     1260

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact     1320

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct     1380

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct     1440

cagcttcagg caccaccact gacctgggac agtcaggtga gtatctcagg gatccagaca     1500

tggggatatg ggaggtgcct ctgatcccag ggctcactgt gggtctctct gttcacaggt     1560

tcagaattcg ccgccaccat gtacagaatg cagctgctgc tgctcattgc cctgtctctg     1620

gccctggtca ccaattctga agtgcagctg gtggaatctg gtggtggact ggttcagcct     1680

ggtggcagcc tgagactgtc ttgtgctgtg tctggcattg acctgtctgg ctactacatg     1740

aactgggtca gacaggcccc tggcaaaggc ctggaatggg ttggagtgat tggcatcaat     1800

ggggccacct actatgccag ctgggccaag ggcagattca ccatcagcag agacaacagc     1860

aagaccacag tgtacctgca gatgaactcc ctgagagctg aggatacagc tgtgtacttc     1920

tgtgccagag gggatatctg gggccagggc acactggtta cagtgtcctc tgccagcaca     1980

aagggcccct ctgtttttcc actggctccc agcagcaaga gcaccagtgg tggaacagct     2040

gccctgggct gtctggtcaa ggattacttc cctgagcctg tgactgtgtc ctggaactct     2100

ggtgcactga cctctggggt gcacaccttt ccagctgtgc tgcagtcctc tggcctgtac     2160

tctctgtcct ctgtggtcac agtgcctagc tctagcctgg gcacccagac ctacatctgc     2220

aatgtgaacc acaagcctag caacaccaaa gtggatgcca gagtggaacc caagagctgt     2280

gacaagaccc acacctgtcc tccatgtcct gctccagaac tgcttggagg cccttctgtg     2340

ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc     2400

tgtgtggtgg ttgatgtgtc ccatgaggac ccagaagtga agttcaattg gtatgtggat     2460

ggggttgaag tgcacaatgc caagaccaag cctagggaag aacagtatgc cagcacctac     2520

agagtggtgt ctgtgctgac agtgctgcac caggactggc tgaatggcaa agagtacaag     2580

tgcaaggtgt ccaacaaggc cctgcctgct cctattgaga aaaccatctc caaggccaag     2640

gggcagccca gagaacctca ggtttacacc ctgccaccta gcagagaaga gatgaccaag     2700

aaccaggtgt ccctgacctg cctggttaag ggcttctacc cctctgacat tgctgtggaa     2760

tgggagagca atggccagcc agagaacaac tacaagacaa cccctcctgt gctggactct     2820

gatggctcat tcttcctgta cagcaagctg actgtggaca agagcagatg gcagcagggc     2880

aatgtgttca gctgctctgt gatgcatgag gccctgcaca accactacac ccagaaaagc     2940

ctgtctctga gccctggcaa gagaaagaga agaggctctg gagaaggcag aggctccctg     3000

ctgacatgtg gggatgttga agagaatcct gggcctatgt ataggatgca actgctcctc     3060

ctgattgctc tgagcctggc tcttgtgacc aactctcagg ttctgacaca gagccctagc     3120

agcctgtctg cttctgtggg agacagagtg accatcaact gccaggcctc tcagtctgtg     3180

taccacaaca cctacctggc ctggtatcag caaaagcctg gcaaggtgcc caagcagctg     3240

atctatgatg cctctacact ggcatcaggg gtgccctcca gattttctgg ctctggatct     3300

ggcactgact tcaccctgac catcagtagc ctgcagcctg aagatgtggc cacctattac     3360

tgcctgggca gctatgactg caccaatggg gactgctttg tgtttggtgg tggcaccaag     3420

gtggaaatca agagaacagt ggctgcccca tctgtgttca tcttcccacc atctgatgaa     3480

cagctgaaga gtggcacagc ctctgttgtg tgcctgctga acaacttcta ccctagagaa     3540

gccaaggtgc agtggaaggt ggacaatgcc ctgcagtctg gcaacagcca agaatctgtg     3600

acagagcagg actccaagga ttccacctac agcctgagca gcaccctgac actgagcaag     3660

gctgactatg agaagcacaa agtgtatgcc tgtgaagtga cacaccaggg actgagcagc     3720

ccagtgacca agagcttcaa caggggagag tgctgataac tcgaggacgg ggtgaactac     3780

gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt     3840

gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat     3900

tttttgtgtc tctcactcgg cggccgcccg agtttaattg gtttatagaa ctcttcaagc     3960

tagcgaagca attcgttgat ctgaatttcg accacccata atacccatta ccctggtaga     4020

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     4080

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     4140

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agccttaatt aacc           4194


<210>  283
<211>  2175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  283
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

caggtgcagc tggttcagtc tggggctgaa gtgaagaaac ctggcagctc tgtgaaggtg      120

tcctgcaagg cctctggcta cacctttggc aactactgga tgcagtgggt cagacaggct      180

cctggccaag gacttgaatg gatgggagcc atctatgaag gcacaggcaa gacagtgtac      240

atccagaagt ttgctgacag ggtcaccatc acagctgaca agagcaccag cacagcctac      300

atggaactga gcagcctgag atctgaggac acagcagtgt actactgtgc cagactgtct      360

gactatgtgt ctggctttgg ctactggggc cagggcacaa cagtgacagt gtcctctgcc      420

agcacaaagg gcccctctgt tttccctctg gctccttgct ctagaagcac ctctgagtct      480

acagctgccc tgggctgcct ggtcaaggat tactttcctg agcctgtgac tgtgtcctgg      540

aactctggtg cactgacctc tggggtgcac acctttccag ctgtgctgca gtcctctggc      600

ctgtactctc tgtcctctgt ggtcacagtg cctagcagca gcctgggcac caagacctac      660

acctgtaatg tggaccacaa gcctagcaac accaaggtgg acaagagggt tgagtctaag      720

tatggccctc cttgtcctcc atgtcctgct ccagaagcag ctggaggccc ttctgtgttc      780

ctgtttcctc caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt      840

gtggtggtgg atgtgtccca agaggaccct gaggtgcagt tcaattggta tgtggatggg      900

gttgaagtgc acaatgccaa gaccaagcct agagaggaac agttcaacag cacctacaga      960

gtggtgtctg tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc     1020

aaggtgtcca acaagggcct gccaagcagc attgagaaaa ccatcagcaa ggccaagggc     1080

cagcctaggg aacctcaggt ttacaccctg cctccaagcc aagaggaaat gaccaagaac     1140

caggtgtccc tgacctgcct tgtgaagggc ttctacccct ctgacattgc tgtggaatgg     1200

gagagcaatg gccagccaga gaacaactac aagacaaccc ctcctgtgct ggactctgat     1260

ggcagcttct tcctgtacag cagactgaca gtggacaagt ccagatggca agagggcaat     1320

gtgttcagct gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaagtctctg     1380

tctctgagcc tgggaagaaa gagaagaggc tctggagaag gcagaggctc cctgctgaca     1440

tgtggggatg ttgaagagaa tcctgggcct atgtatagga tgcaactgct cctcctgatt     1500

gctctgagcc tggctcttgt gaccaactct gacatccaga tgacacagag cccatcttct     1560

ctgtctgcat ctgtgggaga cagagtgacc atcacctgta gagccagcaa ggacatctcc     1620

aagtacctga actggtatca gcaaaagcct ggcaaggccc ctaagctgct gatctactac     1680

acatctggct accacagtgg ggtgcccagc agattttctg gctctggatc tggcactgac     1740

ttcaccctga ccatctctag cctgcagcca gaggattttg ccacctacta ttgtcagcaa     1800

ggggatgccc tgccaccaac ctttggtggt ggcacaaagg tggaaatcaa gagaacagtg     1860

gctgccccat ctgtgttcat cttcccacca tctgatgaac agctgaagag tggcacagcc     1920

tctgttgtgt gcctgctgaa caacttctac cctagagaag ccaaggtgca gtggaaagtg     1980

gataatgccc tgcagtcagg caacagccaa gagtctgtga cagagcagga ctccaaggat     2040

tccacctaca gcctgagcag caccctgaca ctgagcaagg ctgactatga gaagcacaaa     2100

gtgtatgcct gtgaagtgac acaccaggga ctgtctagcc cagtgaccaa gagcttcaac     2160

aggggagagt gctga                                                      2175


<210>  284
<211>  4079
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  284
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcgccg     1740

ccaccatgta cagaatgcag ctgctgctgc tcattgccct gtctctggcc ctggtcacca     1800

attctcaggt gcagctggtt cagtctgggg ctgaagtgaa gaaacctggc agctctgtga     1860

aggtgtcctg caaggcctct ggctacacct ttggcaacta ctggatgcag tgggtcagac     1920

aggctcctgg ccaaggactt gaatggatgg gagccatcta tgaaggcaca ggcaagacag     1980

tgtacatcca gaagtttgct gacagggtca ccatcacagc tgacaagagc accagcacag     2040

cctacatgga actgagcagc ctgagatctg aggacacagc agtgtactac tgtgccagac     2100

tgtctgacta tgtgtctggc tttggctact ggggccaggg cacaacagtg acagtgtcct     2160

ctgccagcac aaagggcccc tctgttttcc ctctggctcc ttgctctaga agcacctctg     2220

agtctacagc tgccctgggc tgcctggtca aggattactt tcctgagcct gtgactgtgt     2280

cctggaactc tggtgcactg acctctgggg tgcacacctt tccagctgtg ctgcagtcct     2340

ctggcctgta ctctctgtcc tctgtggtca cagtgcctag cagcagcctg ggcaccaaga     2400

cctacacctg taatgtggac cacaagccta gcaacaccaa ggtggacaag agggttgagt     2460

ctaagtatgg ccctccttgt cctccatgtc ctgctccaga agcagctgga ggcccttctg     2520

tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc cctgaagtga     2580

cctgtgtggt ggtggatgtg tcccaagagg accctgaggt gcagttcaat tggtatgtgg     2640

atggggttga agtgcacaat gccaagacca agcctagaga ggaacagttc aacagcacct     2700

acagagtggt gtctgtgctg acagtgctgc accaggactg gctgaatggc aaagagtaca     2760

agtgcaaggt gtccaacaag ggcctgccaa gcagcattga gaaaaccatc agcaaggcca     2820

agggccagcc tagggaacct caggtttaca ccctgcctcc aagccaagag gaaatgacca     2880

agaaccaggt gtccctgacc tgccttgtga agggcttcta cccctctgac attgctgtgg     2940

aatgggagag caatggccag ccagagaaca actacaagac aacccctcct gtgctggact     3000

ctgatggcag cttcttcctg tacagcagac tgacagtgga caagtccaga tggcaagagg     3060

gcaatgtgtt cagctgctct gtgatgcatg aggccctgca caaccactac acccagaagt     3120

ctctgtctct gagcctggga agaaagagaa gaggctctgg agaaggcaga ggctccctgc     3180

tgacatgtgg ggatgttgaa gagaatcctg ggcctatgta taggatgcaa ctgctcctcc     3240

tgattgctct gagcctggct cttgtgacca actctgacat ccagatgaca cagagcccat     3300

cttctctgtc tgcatctgtg ggagacagag tgaccatcac ctgtagagcc agcaaggaca     3360

tctccaagta cctgaactgg tatcagcaaa agcctggcaa ggcccctaag ctgctgatct     3420

actacacatc tggctaccac agtggggtgc ccagcagatt ttctggctct ggatctggca     3480

ctgacttcac cctgaccatc tctagcctgc agccagagga ttttgccacc tactattgtc     3540

agcaagggga tgccctgcca ccaacctttg gtggtggcac aaaggtggaa atcaagagaa     3600

cagtggctgc cccatctgtg ttcatcttcc caccatctga tgaacagctg aagagtggca     3660

cagcctctgt tgtgtgcctg ctgaacaact tctaccctag agaagccaag gtgcagtgga     3720

aagtggataa tgccctgcag tcaggcaaca gccaagagtc tgtgacagag caggactcca     3780

aggattccac ctacagcctg agcagcaccc tgacactgag caaggctgac tatgagaagc     3840

acaaagtgta tgcctgtgaa gtgacacacc agggactgtc tagcccagtg accaagagct     3900

tcaacagggg agagtgctga taactcgagg acggggtgaa ctacgcctga ggatccgatc     3960

tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat ctgacttctg     4020

gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg tgtctctca      4079


<210>  285
<211>  4548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  285
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg      240

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      300

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      360

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      420

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      480

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      540

cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc      600

ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa      660

ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg      720

cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc      780

gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga      840

agcgcgcggc gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc      900

gcctcgcgcc gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg      960

gacggccctt ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt     1020

ctgtggctgc gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc     1080

tcggggggtg cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc     1140

ggcggctgtg agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag     1200

gggagcgcgg ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc     1260

tgcgtgcggg gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg     1320

caaccccccc tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg     1380

ctccgtacgg ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg     1440

gtgccgggcg gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc     1500

ccccggagcg ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa     1560

tcgtgcgaga gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg     1620

aggcgccgcc gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag     1680

gaaatgggcg gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag     1740

cctcggggct gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc     1800

ggcttctggc gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc     1860

tttttcctac agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa     1920

gaattcgccg ccaccatgta cagaatgcag ctgctgctgc tcattgccct gtctctggcc     1980

ctggtcacca attctcaggt gcagctggtt cagtctgggg ctgaagtgaa gaaacctggc     2040

agctctgtga aggtgtcctg caaggcctct ggctacacct ttggcaacta ctggatgcag     2100

tgggtcagac aggctcctgg ccaaggactt gaatggatgg gagccatcta tgaaggcaca     2160

ggcaagacag tgtacatcca gaagtttgct gacagggtca ccatcacagc tgacaagagc     2220

accagcacag cctacatgga actgagcagc ctgagatctg aggacacagc agtgtactac     2280

tgtgccagac tgtctgacta tgtgtctggc tttggctact ggggccaggg cacaacagtg     2340

acagtgtcct ctgccagcac aaagggcccc tctgttttcc ctctggctcc ttgctctaga     2400

agcacctctg agtctacagc tgccctgggc tgcctggtca aggattactt tcctgagcct     2460

gtgactgtgt cctggaactc tggtgcactg acctctgggg tgcacacctt tccagctgtg     2520

ctgcagtcct ctggcctgta ctctctgtcc tctgtggtca cagtgcctag cagcagcctg     2580

ggcaccaaga cctacacctg taatgtggac cacaagccta gcaacaccaa ggtggacaag     2640

agggttgagt ctaagtatgg ccctccttgt cctccatgtc ctgctccaga agcagctgga     2700

ggcccttctg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc     2760

cctgaagtga cctgtgtggt ggtggatgtg tcccaagagg accctgaggt gcagttcaat     2820

tggtatgtgg atggggttga agtgcacaat gccaagacca agcctagaga ggaacagttc     2880

aacagcacct acagagtggt gtctgtgctg acagtgctgc accaggactg gctgaatggc     2940

aaagagtaca agtgcaaggt gtccaacaag ggcctgccaa gcagcattga gaaaaccatc     3000

agcaaggcca agggccagcc tagggaacct caggtttaca ccctgcctcc aagccaagag     3060

gaaatgacca agaaccaggt gtccctgacc tgccttgtga agggcttcta cccctctgac     3120

attgctgtgg aatgggagag caatggccag ccagagaaca actacaagac aacccctcct     3180

gtgctggact ctgatggcag cttcttcctg tacagcagac tgacagtgga caagtccaga     3240

tggcaagagg gcaatgtgtt cagctgctct gtgatgcatg aggccctgca caaccactac     3300

acccagaagt ctctgtctct gagcctggga agaaagagaa gaggctctgg agaaggcaga     3360

ggctccctgc tgacatgtgg ggatgttgaa gagaatcctg ggcctatgta taggatgcaa     3420

ctgctcctcc tgattgctct gagcctggct cttgtgacca actctgacat ccagatgaca     3480

cagagcccat cttctctgtc tgcatctgtg ggagacagag tgaccatcac ctgtagagcc     3540

agcaaggaca tctccaagta cctgaactgg tatcagcaaa agcctggcaa ggcccctaag     3600

ctgctgatct actacacatc tggctaccac agtggggtgc ccagcagatt ttctggctct     3660

ggatctggca ctgacttcac cctgaccatc tctagcctgc agccagagga ttttgccacc     3720

tactattgtc agcaagggga tgccctgcca ccaacctttg gtggtggcac aaaggtggaa     3780

atcaagagaa cagtggctgc cccatctgtg ttcatcttcc caccatctga tgaacagctg     3840

aagagtggca cagcctctgt tgtgtgcctg ctgaacaact tctaccctag agaagccaag     3900

gtgcagtgga aagtggataa tgccctgcag tcaggcaaca gccaagagtc tgtgacagag     3960

caggactcca aggattccac ctacagcctg agcagcaccc tgacactgag caaggctgac     4020

tatgagaagc acaaagtgta tgcctgtgaa gtgacacacc agggactgtc tagcccagtg     4080

accaagagct tcaacagggg agagtgctga taactcgagg acggggtgaa ctacgcctga     4140

ggatccgatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat     4200

ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg     4260

tgtctctcac tcggcggccg cccgagttta attggtttat agaactcttc aagctagcga     4320

agcaattcgt tgatctgaat ttcgaccacc cataataccc attaccctgg tagataagta     4380

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4440

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4500

tgcccgggcg gcctcagtga gcgagcgagc gcgcagcctt aattaacc                  4548


<210>  286
<211>  4018
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  286
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagtc aggtgagtat ctcagggatc cagacatggg gatatgggag     1620

gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttcag aattcgccgc     1680

caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa     1740

ttctcaggtg cagctggttc agtctggggc tgaagtgaag aaacctggca gctctgtgaa     1800

ggtgtcctgc aaggcctctg gctacacctt tggcaactac tggatgcagt gggtcagaca     1860

ggctcctggc caaggacttg aatggatggg agccatctat gaaggcacag gcaagacagt     1920

gtacatccag aagtttgctg acagggtcac catcacagct gacaagagca ccagcacagc     1980

ctacatggaa ctgagcagcc tgagatctga ggacacagca gtgtactact gtgccagact     2040

gtctgactat gtgtctggct ttggctactg gggccagggc acaacagtga cagtgtcctc     2100

tgccagcaca aagggcccct ctgttttccc tctggctcct tgctctagaa gcacctctga     2160

gtctacagct gccctgggct gcctggtcaa ggattacttt cctgagcctg tgactgtgtc     2220

ctggaactct ggtgcactga cctctggggt gcacaccttt ccagctgtgc tgcagtcctc     2280

tggcctgtac tctctgtcct ctgtggtcac agtgcctagc agcagcctgg gcaccaagac     2340

ctacacctgt aatgtggacc acaagcctag caacaccaag gtggacaaga gggttgagtc     2400

taagtatggc cctccttgtc ctccatgtcc tgctccagaa gcagctggag gcccttctgt     2460

gttcctgttt cctccaaagc ctaaggacac cctgatgatc agcagaaccc ctgaagtgac     2520

ctgtgtggtg gtggatgtgt cccaagagga ccctgaggtg cagttcaatt ggtatgtgga     2580

tggggttgaa gtgcacaatg ccaagaccaa gcctagagag gaacagttca acagcaccta     2640

cagagtggtg tctgtgctga cagtgctgca ccaggactgg ctgaatggca aagagtacaa     2700

gtgcaaggtg tccaacaagg gcctgccaag cagcattgag aaaaccatca gcaaggccaa     2760

gggccagcct agggaacctc aggtttacac cctgcctcca agccaagagg aaatgaccaa     2820

gaaccaggtg tccctgacct gccttgtgaa gggcttctac ccctctgaca ttgctgtgga     2880

atgggagagc aatggccagc cagagaacaa ctacaagaca acccctcctg tgctggactc     2940

tgatggcagc ttcttcctgt acagcagact gacagtggac aagtccagat ggcaagaggg     3000

caatgtgttc agctgctctg tgatgcatga ggccctgcac aaccactaca cccagaagtc     3060

tctgtctctg agcctgggaa gaaagagaag aggctctgga gaaggcagag gctccctgct     3120

gacatgtggg gatgttgaag agaatcctgg gcctatgtat aggatgcaac tgctcctcct     3180

gattgctctg agcctggctc ttgtgaccaa ctctgacatc cagatgacac agagcccatc     3240

ttctctgtct gcatctgtgg gagacagagt gaccatcacc tgtagagcca gcaaggacat     3300

ctccaagtac ctgaactggt atcagcaaaa gcctggcaag gcccctaagc tgctgatcta     3360

ctacacatct ggctaccaca gtggggtgcc cagcagattt tctggctctg gatctggcac     3420

tgacttcacc ctgaccatct ctagcctgca gccagaggat tttgccacct actattgtca     3480

gcaaggggat gccctgccac caacctttgg tggtggcaca aaggtggaaa tcaagagaac     3540

agtggctgcc ccatctgtgt tcatcttccc accatctgat gaacagctga agagtggcac     3600

agcctctgtt gtgtgcctgc tgaacaactt ctaccctaga gaagccaagg tgcagtggaa     3660

agtggataat gccctgcagt caggcaacag ccaagagtct gtgacagagc aggactccaa     3720

ggattccacc tacagcctga gcagcaccct gacactgagc aaggctgact atgagaagca     3780

caaagtgtat gcctgtgaag tgacacacca gggactgtct agcccagtga ccaagagctt     3840

caacagggga gagtgctgat aactcgagga cggggtgaac tacgcctgag gatccgatct     3900

ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc tgacttctgg     3960

ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctca       4018


<210>  287
<211>  4487
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  287
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac      240

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca      300

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca      360

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc      420

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt      480

gtcctggcgt ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag      540

gaggcaaggc ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc      600

cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact      660

acgggtttag gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta      720

taattaaccc agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata      780

accctgtccc tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct      840

ggggacaccc gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc      900

caacacctgc tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc      960

ttcgaacaag gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta     1020

tacgtgcctg ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc     1080

ccccgccagc tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc     1140

agcccataca aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt     1200

gcccgggcaa cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc     1260

tcctggctag tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct     1320

cattctacca ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc     1380

ttgctaccag tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg     1440

gtactctccc agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg     1500

tggtttctga gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc     1560

ccaggcaaag cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc     1620

ccctgtttgc tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc     1680

cgttgcccct ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc     1740

ttcaggcacc accactgacc tgggacagtc aggtgagtat ctcagggatc cagacatggg     1800

gatatgggag gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttcag     1860

aattcgccgc caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc     1920

tggtcaccaa ttctcaggtg cagctggttc agtctggggc tgaagtgaag aaacctggca     1980

gctctgtgaa ggtgtcctgc aaggcctctg gctacacctt tggcaactac tggatgcagt     2040

gggtcagaca ggctcctggc caaggacttg aatggatggg agccatctat gaaggcacag     2100

gcaagacagt gtacatccag aagtttgctg acagggtcac catcacagct gacaagagca     2160

ccagcacagc ctacatggaa ctgagcagcc tgagatctga ggacacagca gtgtactact     2220

gtgccagact gtctgactat gtgtctggct ttggctactg gggccagggc acaacagtga     2280

cagtgtcctc tgccagcaca aagggcccct ctgttttccc tctggctcct tgctctagaa     2340

gcacctctga gtctacagct gccctgggct gcctggtcaa ggattacttt cctgagcctg     2400

tgactgtgtc ctggaactct ggtgcactga cctctggggt gcacaccttt ccagctgtgc     2460

tgcagtcctc tggcctgtac tctctgtcct ctgtggtcac agtgcctagc agcagcctgg     2520

gcaccaagac ctacacctgt aatgtggacc acaagcctag caacaccaag gtggacaaga     2580

gggttgagtc taagtatggc cctccttgtc ctccatgtcc tgctccagaa gcagctggag     2640

gcccttctgt gttcctgttt cctccaaagc ctaaggacac cctgatgatc agcagaaccc     2700

ctgaagtgac ctgtgtggtg gtggatgtgt cccaagagga ccctgaggtg cagttcaatt     2760

ggtatgtgga tggggttgaa gtgcacaatg ccaagaccaa gcctagagag gaacagttca     2820

acagcaccta cagagtggtg tctgtgctga cagtgctgca ccaggactgg ctgaatggca     2880

aagagtacaa gtgcaaggtg tccaacaagg gcctgccaag cagcattgag aaaaccatca     2940

gcaaggccaa gggccagcct agggaacctc aggtttacac cctgcctcca agccaagagg     3000

aaatgaccaa gaaccaggtg tccctgacct gccttgtgaa gggcttctac ccctctgaca     3060

ttgctgtgga atgggagagc aatggccagc cagagaacaa ctacaagaca acccctcctg     3120

tgctggactc tgatggcagc ttcttcctgt acagcagact gacagtggac aagtccagat     3180

ggcaagaggg caatgtgttc agctgctctg tgatgcatga ggccctgcac aaccactaca     3240

cccagaagtc tctgtctctg agcctgggaa gaaagagaag aggctctgga gaaggcagag     3300

gctccctgct gacatgtggg gatgttgaag agaatcctgg gcctatgtat aggatgcaac     3360

tgctcctcct gattgctctg agcctggctc ttgtgaccaa ctctgacatc cagatgacac     3420

agagcccatc ttctctgtct gcatctgtgg gagacagagt gaccatcacc tgtagagcca     3480

gcaaggacat ctccaagtac ctgaactggt atcagcaaaa gcctggcaag gcccctaagc     3540

tgctgatcta ctacacatct ggctaccaca gtggggtgcc cagcagattt tctggctctg     3600

gatctggcac tgacttcacc ctgaccatct ctagcctgca gccagaggat tttgccacct     3660

actattgtca gcaaggggat gccctgccac caacctttgg tggtggcaca aaggtggaaa     3720

tcaagagaac agtggctgcc ccatctgtgt tcatcttccc accatctgat gaacagctga     3780

agagtggcac agcctctgtt gtgtgcctgc tgaacaactt ctaccctaga gaagccaagg     3840

tgcagtggaa agtggataat gccctgcagt caggcaacag ccaagagtct gtgacagagc     3900

aggactccaa ggattccacc tacagcctga gcagcaccct gacactgagc aaggctgact     3960

atgagaagca caaagtgtat gcctgtgaag tgacacacca gggactgtct agcccagtga     4020

ccaagagctt caacagggga gagtgctgat aactcgagga cggggtgaac tacgcctgag     4080

gatccgatct ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc     4140

tgacttctgg ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt     4200

gtctctcact cggcggccgc ccgagtttaa ttggtttata gaactcttca agctagcgaa     4260

gcaattcgtt gatctgaatt tcgaccaccc ataataccca ttaccctggt agataagtag     4320

catggcgggt taatcattaa ctacaaggaa cccctagtga tggagttggc cactccctct     4380

ctgcgcgctc gctcgctcac tgaggccggg cgaccaaagg tcgcccgacg cccgggcttt     4440

gcccgggcgg cctcagtgag cgagcgagcg cgcagcctta attaacc                   4487


<210>  288
<211>  3722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  288
taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc tgcctgctga       60

ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg ctcccgtttg      120

acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc ctctcccaga      180

acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct ataaggcgag      240

gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag ctgctaagtt      300

tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca gtgcccagaa      360

aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg gcagggggag      420

gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa gatcttcgaa      480

caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg cttatacgtg      540

cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc tgtcccccgc      600

cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg gggcagccca      660

tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca cggtgcccgg      720

gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag cccctcctgg      780

ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg ccctcattct      840

accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga gatcttgcta      900

ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc      960

tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt     1020

ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc     1080

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt     1140

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc     1200

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg     1260

caccaccact gacctgggac agtcaggtga gtatctcagg gatccagaca tggggatatg     1320

ggaggtgcct ctgatcccag ggctcactgt gggtctctct gttcacaggt tcagaattcg     1380

ccgccaccat gtacagaatg cagctgctgc tgctcattgc cctgtctctg gccctggtca     1440

ccaattctca ggtgcagctg gttcagtctg gggctgaagt gaagaaacct ggcagctctg     1500

tgaaggtgtc ctgcaaggcc tctggctaca cctttggcaa ctactggatg cagtgggtca     1560

gacaggctcc tggccaagga cttgaatgga tgggagccat ctatgaaggc acaggcaaga     1620

cagtgtacat ccagaagttt gctgacaggg tcaccatcac agctgacaag agcaccagca     1680

cagcctacat ggaactgagc agcctgagat ctgaggacac agcagtgtac tactgtgcca     1740

gactgtctga ctatgtgtct ggctttggct actggggcca gggcacaaca gtgacagtgt     1800

cctctgccag cacaaagggc ccctctgttt tccctctggc tccttgctct agaagcacct     1860

ctgagtctac agctgccctg ggctgcctgg tcaaggatta ctttcctgag cctgtgactg     1920

tgtcctggaa ctctggtgca ctgacctctg gggtgcacac ctttccagct gtgctgcagt     1980

cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagcagcagc ctgggcacca     2040

agacctacac ctgtaatgtg gaccacaagc ctagcaacac caaggtggac aagagggttg     2100

agtctaagta tggccctcct tgtcctccat gtcctgctcc agaagcagct ggaggccctt     2160

ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga acccctgaag     2220

tgacctgtgt ggtggtggat gtgtcccaag aggaccctga ggtgcagttc aattggtatg     2280

tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag ttcaacagca     2340

cctacagagt ggtgtctgtg ctgacagtgc tgcaccagga ctggctgaat ggcaaagagt     2400

acaagtgcaa ggtgtccaac aagggcctgc caagcagcat tgagaaaacc atcagcaagg     2460

ccaagggcca gcctagggaa cctcaggttt acaccctgcc tccaagccaa gaggaaatga     2520

ccaagaacca ggtgtccctg acctgccttg tgaagggctt ctacccctct gacattgctg     2580

tggaatggga gagcaatggc cagccagaga acaactacaa gacaacccct cctgtgctgg     2640

actctgatgg cagcttcttc ctgtacagca gactgacagt ggacaagtcc agatggcaag     2700

agggcaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac tacacccaga     2760

agtctctgtc tctgagcctg ggaagaaaga gaagaggctc tggagaaggc agaggctccc     2820

tgctgacatg tggggatgtt gaagagaatc ctgggcctat gtataggatg caactgctcc     2880

tcctgattgc tctgagcctg gctcttgtga ccaactctga catccagatg acacagagcc     2940

catcttctct gtctgcatct gtgggagaca gagtgaccat cacctgtaga gccagcaagg     3000

acatctccaa gtacctgaac tggtatcagc aaaagcctgg caaggcccct aagctgctga     3060

tctactacac atctggctac cacagtgggg tgcccagcag attttctggc tctggatctg     3120

gcactgactt caccctgacc atctctagcc tgcagccaga ggattttgcc acctactatt     3180

gtcagcaagg ggatgccctg ccaccaacct ttggtggtgg cacaaaggtg gaaatcaaga     3240

gaacagtggc tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagagtg     3300

gcacagcctc tgttgtgtgc ctgctgaaca acttctaccc tagagaagcc aaggtgcagt     3360

ggaaagtgga taatgccctg cagtcaggca acagccaaga gtctgtgaca gagcaggact     3420

ccaaggattc cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga     3480

agcacaaagt gtatgcctgt gaagtgacac accagggact gtctagccca gtgaccaaga     3540

gcttcaacag gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg     3600

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     3660

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     3720

ca                                                                    3722


<210>  289
<211>  4179
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  289
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      240

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg      300

ctcccgtttg acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc      360

ctctcccaga acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct      420

ataaggcgag gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag      480

ctgctaagtt tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca      540

gtgcccagaa aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg      600

gcagggggag gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa      660

gatcttcgaa caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg      720

cttatacgtg cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc      780

tgtcccccgc cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg      840

gggcagccca tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca      900

cggtgcccgg gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag      960

cccctcctgg ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg     1020

ccctcattct accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga     1080

gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta     1140

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac     1200

gctgtggttt ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca     1260

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact     1320

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct     1380

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct     1440

cagcttcagg caccaccact gacctgggac agtcaggtga gtatctcagg gatccagaca     1500

tggggatatg ggaggtgcct ctgatcccag ggctcactgt gggtctctct gttcacaggt     1560

tcagaattcg ccgccaccat gtacagaatg cagctgctgc tgctcattgc cctgtctctg     1620

gccctggtca ccaattctca ggtgcagctg gttcagtctg gggctgaagt gaagaaacct     1680

ggcagctctg tgaaggtgtc ctgcaaggcc tctggctaca cctttggcaa ctactggatg     1740

cagtgggtca gacaggctcc tggccaagga cttgaatgga tgggagccat ctatgaaggc     1800

acaggcaaga cagtgtacat ccagaagttt gctgacaggg tcaccatcac agctgacaag     1860

agcaccagca cagcctacat ggaactgagc agcctgagat ctgaggacac agcagtgtac     1920

tactgtgcca gactgtctga ctatgtgtct ggctttggct actggggcca gggcacaaca     1980

gtgacagtgt cctctgccag cacaaagggc ccctctgttt tccctctggc tccttgctct     2040

agaagcacct ctgagtctac agctgccctg ggctgcctgg tcaaggatta ctttcctgag     2100

cctgtgactg tgtcctggaa ctctggtgca ctgacctctg gggtgcacac ctttccagct     2160

gtgctgcagt cctctggcct gtactctctg tcctctgtgg tcacagtgcc tagcagcagc     2220

ctgggcacca agacctacac ctgtaatgtg gaccacaagc ctagcaacac caaggtggac     2280

aagagggttg agtctaagta tggccctcct tgtcctccat gtcctgctcc agaagcagct     2340

ggaggccctt ctgtgttcct gtttcctcca aagcctaagg acaccctgat gatcagcaga     2400

acccctgaag tgacctgtgt ggtggtggat gtgtcccaag aggaccctga ggtgcagttc     2460

aattggtatg tggatggggt tgaagtgcac aatgccaaga ccaagcctag agaggaacag     2520

ttcaacagca cctacagagt ggtgtctgtg ctgacagtgc tgcaccagga ctggctgaat     2580

ggcaaagagt acaagtgcaa ggtgtccaac aagggcctgc caagcagcat tgagaaaacc     2640

atcagcaagg ccaagggcca gcctagggaa cctcaggttt acaccctgcc tccaagccaa     2700

gaggaaatga ccaagaacca ggtgtccctg acctgccttg tgaagggctt ctacccctct     2760

gacattgctg tggaatggga gagcaatggc cagccagaga acaactacaa gacaacccct     2820

cctgtgctgg actctgatgg cagcttcttc ctgtacagca gactgacagt ggacaagtcc     2880

agatggcaag agggcaatgt gttcagctgc tctgtgatgc atgaggccct gcacaaccac     2940

tacacccaga agtctctgtc tctgagcctg ggaagaaaga gaagaggctc tggagaaggc     3000

agaggctccc tgctgacatg tggggatgtt gaagagaatc ctgggcctat gtataggatg     3060

caactgctcc tcctgattgc tctgagcctg gctcttgtga ccaactctga catccagatg     3120

acacagagcc catcttctct gtctgcatct gtgggagaca gagtgaccat cacctgtaga     3180

gccagcaagg acatctccaa gtacctgaac tggtatcagc aaaagcctgg caaggcccct     3240

aagctgctga tctactacac atctggctac cacagtgggg tgcccagcag attttctggc     3300

tctggatctg gcactgactt caccctgacc atctctagcc tgcagccaga ggattttgcc     3360

acctactatt gtcagcaagg ggatgccctg ccaccaacct ttggtggtgg cacaaaggtg     3420

gaaatcaaga gaacagtggc tgccccatct gtgttcatct tcccaccatc tgatgaacag     3480

ctgaagagtg gcacagcctc tgttgtgtgc ctgctgaaca acttctaccc tagagaagcc     3540

aaggtgcagt ggaaagtgga taatgccctg cagtcaggca acagccaaga gtctgtgaca     3600

gagcaggact ccaaggattc cacctacagc ctgagcagca ccctgacact gagcaaggct     3660

gactatgaga agcacaaagt gtatgcctgt gaagtgacac accagggact gtctagccca     3720

gtgaccaaga gcttcaacag gggagagtgc tgataactcg aggacggggt gaactacgcc     3780

tgaggatccg atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     3840

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     3900

ttgtgtctct cactcggcgg ccgcccgagt ttaattggtt tatagaactc ttcaagctag     3960

cgaagcaatt cgttgatctg aatttcgacc acccataata cccattaccc tggtagataa     4020

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     4080

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4140

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag                            4179


<210>  290
<211>  2178
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  290
atgtacagaa tgcagctgct gctgctcatt gccctgtctc tggccctggt caccaattct       60

gaagtgcagc tggtggaatc tggtggtgga ctggttcagc ctggtggcag cctgagactg      120

tcttgtgctg tgtctggcat tgacctgtct ggctactaca tgaactgggt cagacaggcc      180

cctggcaaag gcctggaatg ggttggagtg attggcatca atggggccac ctactatgcc      240

agctgggcca agggcagatt caccatcagc agagacaaca gcaagaccac agtgtacctg      300

cagatgaact ccctgagagc tgaggataca gctgtgtact tctgtgccag aggggatatc      360

tggggccagg gcacactggt tacagtgtcc tctgccagca caaagggccc ctctgttttt      420

ccactggctc ccagcagcaa gagcaccagt ggtggaacag ctgccctggg ctgtctggtc      480

aaggattact tccctgagcc tgtgactgtg tcctggaact ctggtgcact gacctctggg      540

gtgcacacct ttccagctgt gctgcagtcc tctggcctgt actctctgtc ctctgtggtc      600

acagtgccta gctctagcct gggcacccag acctacatct gcaatgtgaa ccacaagcct      660

agcaacacca aagtggatgc cagagtggaa cccaagagct gtgacaagac ccacacctgt      720

cctccatgtc ctgctccaga actgcttgga ggcccttctg tgttcctgtt tcctccaaag      780

cctaaggaca ccctgatgat cagcagaacc cctgaagtga cctgtgtggt ggttgatgtg      840

tcccatgagg acccagaagt gaagttcaat tggtatgtgg atggggttga agtgcacaat      900

gccaagacca agcctaggga agaacagtat gccagcacct acagagtggt gtctgtgctg      960

acagtgctgc accaggactg gctgaatggc aaagagtaca agtgcaaggt gtccaacaag     1020

gccctgcctg ctcctattga gaaaaccatc tccaaggcca aggggcagcc cagagaacct     1080

caggtttaca ccctgccacc tagcagagaa gagatgacca agaaccaggt gtccctgacc     1140

tgcctggtta agggcttcta cccctctgac attgctgtgg aatgggagag caatggccag     1200

ccagagaaca actacaagac aacccctcct gtgctggact ctgatggctc attcttcctg     1260

tacagcaagc tgactgtgga caagagcaga tggcagcagg gcaatgtgtt cagctgctct     1320

gtgatgcatg aggccctgca caaccactac acccagaaaa gcctgtctct gagccctggc     1380

aagagaaaga gaagaggctc tggagaaggc agaggctccc tgctgacatg tggggatgtt     1440

gaagagaatc ctgggcctat gtataggatg caactgctcc tcctgattgc tctgagcctg     1500

gctcttgtga ccaactctca ggttctgaca cagagcccta gcagcctgtc tgcttctgtg     1560

ggagacagag tgaccatcaa ctgccaggcc tctcagtctg tgtaccacaa cacctacctg     1620

gcctggtatc agcaaaagcc tggcaaggtg cccaagcagc tgatctatga tgcctctaca     1680

ctggcatcag gggtgccctc cagattttct ggctctggat ctggcactga cttcaccctg     1740

accatcagta gcctgcagcc tgaagatgtg gccacctatt actgcctggg cagctatgac     1800

tgcaccaatg gggactgctt tgtgtttggt ggtggcacca aggtggaaat caagagaaca     1860

gtggctgccc catctgtgtt catcttccca ccatctgatg aacagctgaa gagtggcaca     1920

gcctctgttg tgtgcctgct gaacaacttc taccctagag aagccaaggt gcagtggaag     1980

gtggacaatg ccctgcagtc tggcaacagc caagaatctg tgacagagca ggactccaag     2040

gattccacct acagcctgag cagcaccctg acactgagca aggctgacta tgagaagcac     2100

aaagtgtatg cctgtgaagt gacacaccag ggactgagca gcccagtgac caagagcttc     2160

aacaggggag agtgctga                                                   2178


<210>  291
<211>  2118
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  291
gaagtgcagc tggtggaatc tggtggtgga ctggttcagc ctggtggcag cctgagactg       60

tcttgtgctg tgtctggcat tgacctgtct ggctactaca tgaactgggt cagacaggcc      120

cctggcaaag gcctggaatg ggttggagtg attggcatca atggggccac ctactatgcc      180

agctgggcca agggcagatt caccatcagc agagacaaca gcaagaccac agtgtacctg      240

cagatgaact ccctgagagc tgaggataca gctgtgtact tctgtgccag aggggatatc      300

tggggccagg gcacactggt tacagtgtcc tctgccagca caaagggccc ctctgttttt      360

ccactggctc ccagcagcaa gagcaccagt ggtggaacag ctgccctggg ctgtctggtc      420

aaggattact tccctgagcc tgtgactgtg tcctggaact ctggtgcact gacctctggg      480

gtgcacacct ttccagctgt gctgcagtcc tctggcctgt actctctgtc ctctgtggtc      540

acagtgccta gctctagcct gggcacccag acctacatct gcaatgtgaa ccacaagcct      600

agcaacacca aagtggatgc cagagtggaa cccaagagct gtgacaagac ccacacctgt      660

cctccatgtc ctgctccaga actgcttgga ggcccttctg tgttcctgtt tcctccaaag      720

cctaaggaca ccctgatgat cagcagaacc cctgaagtga cctgtgtggt ggttgatgtg      780

tcccatgagg acccagaagt gaagttcaat tggtatgtgg atggggttga agtgcacaat      840

gccaagacca agcctaggga agaacagtat gccagcacct acagagtggt gtctgtgctg      900

acagtgctgc accaggactg gctgaatggc aaagagtaca agtgcaaggt gtccaacaag      960

gccctgcctg ctcctattga gaaaaccatc tccaaggcca aggggcagcc cagagaacct     1020

caggtttaca ccctgccacc tagcagagaa gagatgacca agaaccaggt gtccctgacc     1080

tgcctggtta agggcttcta cccctctgac attgctgtgg aatgggagag caatggccag     1140

ccagagaaca actacaagac aacccctcct gtgctggact ctgatggctc attcttcctg     1200

tacagcaagc tgactgtgga caagagcaga tggcagcagg gcaatgtgtt cagctgctct     1260

gtgatgcatg aggccctgca caaccactac acccagaaaa gcctgtctct gagccctggc     1320

aagagaaaga gaagaggctc tggagaaggc agaggctccc tgctgacatg tggggatgtt     1380

gaagagaatc ctgggcctat gtataggatg caactgctcc tcctgattgc tctgagcctg     1440

gctcttgtga ccaactctca ggttctgaca cagagcccta gcagcctgtc tgcttctgtg     1500

ggagacagag tgaccatcaa ctgccaggcc tctcagtctg tgtaccacaa cacctacctg     1560

gcctggtatc agcaaaagcc tggcaaggtg cccaagcagc tgatctatga tgcctctaca     1620

ctggcatcag gggtgccctc cagattttct ggctctggat ctggcactga cttcaccctg     1680

accatcagta gcctgcagcc tgaagatgtg gccacctatt actgcctggg cagctatgac     1740

tgcaccaatg gggactgctt tgtgtttggt ggtggcacca aggtggaaat caagagaaca     1800

gtggctgccc catctgtgtt catcttccca ccatctgatg aacagctgaa gagtggcaca     1860

gcctctgttg tgtgcctgct gaacaacttc taccctagag aagccaaggt gcagtggaag     1920

gtggacaatg ccctgcagtc tggcaacagc caagaatctg tgacagagca ggactccaag     1980

gattccacct acagcctgag cagcaccctg acactgagca aggctgacta tgagaagcac     2040

aaagtgtatg cctgtgaagt gacacaccag ggactgagca gcccagtgac caagagcttc     2100

aacaggggag agtgctga                                                   2118


<210>  292
<211>  4082
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  292
ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc       60

atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac      120

cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa      180

tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag      240

tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc      300

ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct      360

acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc ttcactctcc      420

ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa ttattttgtg      480

cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg cggggcgagg      540

ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa      600

agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga agcgcgcggc      660

gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc gcctcgcgcc      720

gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg gacggccctt      780

ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt ctgtggctgc      840

gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc tcggggggtg      900

cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc ggcggctgtg      960

agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag gggagcgcgg     1020

ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc tgcgtgcggg     1080

gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg caaccccccc     1140

tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg ctccgtacgg     1200

ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg gtgccgggcg     1260

gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc ccccggagcg     1320

ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa tcgtgcgaga     1380

gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg aggcgccgcc     1440

gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag gaaatgggcg     1500

gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag cctcggggct     1560

gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc ggcttctggc     1620

gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc tttttcctac     1680

agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa gaattcgccg     1740

ccaccatgta cagaatgcag ctgctgctgc tcattgccct gtctctggcc ctggtcacca     1800

attctgaagt gcagctggtg gaatctggtg gtggactggt tcagcctggt ggcagcctga     1860

gactgtcttg tgctgtgtct ggcattgacc tgtctggcta ctacatgaac tgggtcagac     1920

aggcccctgg caaaggcctg gaatgggttg gagtgattgg catcaatggg gccacctact     1980

atgccagctg ggccaagggc agattcacca tcagcagaga caacagcaag accacagtgt     2040

acctgcagat gaactccctg agagctgagg atacagctgt gtacttctgt gccagagggg     2100

atatctgggg ccagggcaca ctggttacag tgtcctctgc cagcacaaag ggcccctctg     2160

tttttccact ggctcccagc agcaagagca ccagtggtgg aacagctgcc ctgggctgtc     2220

tggtcaagga ttacttccct gagcctgtga ctgtgtcctg gaactctggt gcactgacct     2280

ctggggtgca cacctttcca gctgtgctgc agtcctctgg cctgtactct ctgtcctctg     2340

tggtcacagt gcctagctct agcctgggca cccagaccta catctgcaat gtgaaccaca     2400

agcctagcaa caccaaagtg gatgccagag tggaacccaa gagctgtgac aagacccaca     2460

cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc ctgtttcctc     2520

caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt gtggtggttg     2580

atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg gttgaagtgc     2640

acaatgccaa gaccaagcct agggaagaac agtatgccag cacctacaga gtggtgtctg     2700

tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc aaggtgtcca     2760

acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggg cagcccagag     2820

aacctcaggt ttacaccctg ccacctagca gagaagagat gaccaagaac caggtgtccc     2880

tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg gagagcaatg     2940

gccagccaga gaacaactac aagacaaccc ctcctgtgct ggactctgat ggctcattct     3000

tcctgtacag caagctgact gtggacaaga gcagatggca gcagggcaat gtgttcagct     3060

gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagcctg tctctgagcc     3120

ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg acatgtgggg     3180

atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg attgctctga     3240

gcctggctct tgtgaccaac tctcaggttc tgacacagag ccctagcagc ctgtctgctt     3300

ctgtgggaga cagagtgacc atcaactgcc aggcctctca gtctgtgtac cacaacacct     3360

acctggcctg gtatcagcaa aagcctggca aggtgcccaa gcagctgatc tatgatgcct     3420

ctacactggc atcaggggtg ccctccagat tttctggctc tggatctggc actgacttca     3480

ccctgaccat cagtagcctg cagcctgaag atgtggccac ctattactgc ctgggcagct     3540

atgactgcac caatggggac tgctttgtgt ttggtggtgg caccaaggtg gaaatcaaga     3600

gaacagtggc tgccccatct gtgttcatct tcccaccatc tgatgaacag ctgaagagtg     3660

gcacagcctc tgttgtgtgc ctgctgaaca acttctaccc tagagaagcc aaggtgcagt     3720

ggaaggtgga caatgccctg cagtctggca acagccaaga atctgtgaca gagcaggact     3780

ccaaggattc cacctacagc ctgagcagca ccctgacact gagcaaggct gactatgaga     3840

agcacaaagt gtatgcctgt gaagtgacac accagggact gagcagccca gtgaccaaga     3900

gcttcaacag gggagagtgc tgataactcg aggacggggt gaactacgcc tgaggatccg     3960

atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt     4020

ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct     4080

ca                                                                    4082


<210>  293
<211>  4551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  293
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga ctagtcgaca ttgattattg actagttatt aatagtaatc aattacgggg      240

tcattagttc atagcccata tatggagttc cgcgttacat aacttacggt aaatggcccg      300

cctggctgac cgcccaacga cccccgccca ttgacgtcaa taatgacgta tgttcccata      360

gtaacgccaa tagggacttt ccattgacgt caatgggtgg agtatttacg gtaaactgcc      420

cacttggcag tacatcaagt gtatcatatg ccaagtacgc cccctattga cgtcaatgac      480

ggtaaatggc ccgcctggca ttatgcccag tacatgacct tatgggactt tcctacttgg      540

cagtacatct acgtattagt catcgctatt accatggtcg aggtgagccc cacgttctgc      600

ttcactctcc ccatctcccc cccctcccca cccccaattt tgtatttatt tattttttaa      660

ttattttgtg cagcgatggg ggcggggggg gggggggggc gcgcgccagg cggggcgggg      720

cggggcgagg ggcggggcgg ggcgaggcgg agaggtgcgg cggcagccaa tcagagcggc      780

gcgctccgaa agtttccttt tatggcgagg cggcggcggc ggcggcccta taaaaagcga      840

agcgcgcggc gggcgggagt cgctgcgcgc tgccttcgcc ccgtgccccg ctccgccgcc      900

gcctcgcgcc gcccgccccg gctctgactg accgcgttac tcccacaggt gagcgggcgg      960

gacggccctt ctcctccggg ctgtaattag cgcttggttt aatgacggct tgtttctttt     1020

ctgtggctgc gtgaaagcct tgaggggctc cgggagggcc ctttgtgcgg ggggagcggc     1080

tcggggggtg cgtgcgtgtg tgtgtgcgtg gggagcgccg cgtgcggctc cgcgctgccc     1140

ggcggctgtg agcgctgcgg gcgcggcgcg gggctttgtg cgctccgcag tgtgcgcgag     1200

gggagcgcgg ccgggggcgg tgccccgcgg tgcggggggg gctgcgaggg gaacaaaggc     1260

tgcgtgcggg gtgtgtgcgt gggggggtga gcagggggtg tgggcgcgtc ggtcgggctg     1320

caaccccccc tgcacccccc tccccgagtt gctgagcacg gcccggcttc gggtgcgggg     1380

ctccgtacgg ggcgtggcgc ggggctcgcc gtgccgggcg gggggtggcg gcaggtgggg     1440

gtgccgggcg gggcggggcc gcctcgggcc ggggagggct cgggggaggg gcgcggcggc     1500

ccccggagcg ccggcggctg tcgaggcgcg gcgagccgca gccattgcct tttatggtaa     1560

tcgtgcgaga gggcgcaggg acttcctttg tcccaaatct gtgcggagcc gaaatctggg     1620

aggcgccgcc gcaccccctc tagcgggcgc ggggcgaagc ggtgcggcgc cggcaggaag     1680

gaaatgggcg gggagggcct tcgtgcgtcg ccgcgccgcc gtccccttct ccctctccag     1740

cctcggggct gtccgcgggg ggacggctgc cttcgggggg gacggggcag ggcggggttc     1800

ggcttctggc gtgtgaccgg cggctctaga gcctctgcta accatgttca tgccttcttc     1860

tttttcctac agctcctggg caacgtgctg gttattgtgc tgtctcatca ttttggcaaa     1920

gaattcgccg ccaccatgta cagaatgcag ctgctgctgc tcattgccct gtctctggcc     1980

ctggtcacca attctgaagt gcagctggtg gaatctggtg gtggactggt tcagcctggt     2040

ggcagcctga gactgtcttg tgctgtgtct ggcattgacc tgtctggcta ctacatgaac     2100

tgggtcagac aggcccctgg caaaggcctg gaatgggttg gagtgattgg catcaatggg     2160

gccacctact atgccagctg ggccaagggc agattcacca tcagcagaga caacagcaag     2220

accacagtgt acctgcagat gaactccctg agagctgagg atacagctgt gtacttctgt     2280

gccagagggg atatctgggg ccagggcaca ctggttacag tgtcctctgc cagcacaaag     2340

ggcccctctg tttttccact ggctcccagc agcaagagca ccagtggtgg aacagctgcc     2400

ctgggctgtc tggtcaagga ttacttccct gagcctgtga ctgtgtcctg gaactctggt     2460

gcactgacct ctggggtgca cacctttcca gctgtgctgc agtcctctgg cctgtactct     2520

ctgtcctctg tggtcacagt gcctagctct agcctgggca cccagaccta catctgcaat     2580

gtgaaccaca agcctagcaa caccaaagtg gatgccagag tggaacccaa gagctgtgac     2640

aagacccaca cctgtcctcc atgtcctgct ccagaactgc ttggaggccc ttctgtgttc     2700

ctgtttcctc caaagcctaa ggacaccctg atgatcagca gaacccctga agtgacctgt     2760

gtggtggttg atgtgtccca tgaggaccca gaagtgaagt tcaattggta tgtggatggg     2820

gttgaagtgc acaatgccaa gaccaagcct agggaagaac agtatgccag cacctacaga     2880

gtggtgtctg tgctgacagt gctgcaccag gactggctga atggcaaaga gtacaagtgc     2940

aaggtgtcca acaaggccct gcctgctcct attgagaaaa ccatctccaa ggccaagggg     3000

cagcccagag aacctcaggt ttacaccctg ccacctagca gagaagagat gaccaagaac     3060

caggtgtccc tgacctgcct ggttaagggc ttctacccct ctgacattgc tgtggaatgg     3120

gagagcaatg gccagccaga gaacaactac aagacaaccc ctcctgtgct ggactctgat     3180

ggctcattct tcctgtacag caagctgact gtggacaaga gcagatggca gcagggcaat     3240

gtgttcagct gctctgtgat gcatgaggcc ctgcacaacc actacaccca gaaaagcctg     3300

tctctgagcc ctggcaagag aaagagaaga ggctctggag aaggcagagg ctccctgctg     3360

acatgtgggg atgttgaaga gaatcctggg cctatgtata ggatgcaact gctcctcctg     3420

attgctctga gcctggctct tgtgaccaac tctcaggttc tgacacagag ccctagcagc     3480

ctgtctgctt ctgtgggaga cagagtgacc atcaactgcc aggcctctca gtctgtgtac     3540

cacaacacct acctggcctg gtatcagcaa aagcctggca aggtgcccaa gcagctgatc     3600

tatgatgcct ctacactggc atcaggggtg ccctccagat tttctggctc tggatctggc     3660

actgacttca ccctgaccat cagtagcctg cagcctgaag atgtggccac ctattactgc     3720

ctgggcagct atgactgcac caatggggac tgctttgtgt ttggtggtgg caccaaggtg     3780

gaaatcaaga gaacagtggc tgccccatct gtgttcatct tcccaccatc tgatgaacag     3840

ctgaagagtg gcacagcctc tgttgtgtgc ctgctgaaca acttctaccc tagagaagcc     3900

aaggtgcagt ggaaggtgga caatgccctg cagtctggca acagccaaga atctgtgaca     3960

gagcaggact ccaaggattc cacctacagc ctgagcagca ccctgacact gagcaaggct     4020

gactatgaga agcacaaagt gtatgcctgt gaagtgacac accagggact gagcagccca     4080

gtgaccaaga gcttcaacag gggagagtgc tgataactcg aggacggggt gaactacgcc     4140

tgaggatccg atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     4200

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     4260

ttgtgtctct cactcggcgg ccgcccgagt ttaattggtt tatagaactc ttcaagctag     4320

cgaagcaatt cgttgatctg aatttcgacc acccataata cccattaccc tggtagataa     4380

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     4440

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4500

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc cttaattaac c              4551


<210>  294
<211>  4021
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  294
aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac ccctcagttc       60

ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca aacttcagcc      120

tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca cacagccctc      180

cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc ccatgccacc      240

tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt gtcctggcgt      300

ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag gaggcaaggc      360

ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc cccccccccc      420

cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact acgggtttag      480

gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta taattaaccc      540

agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata accctgtccc      600

tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct ggggacaccc      660

gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc caacacctgc      720

tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc ttcgaacaag      780

gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta tacgtgcctg      840

ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc ccccgccagc      900

tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc agcccataca      960

aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt gcccgggcaa     1020

cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc tcctggctag     1080

tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct cattctacca     1140

ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc ttgctaccag     1200

tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg gtactctccc     1260

agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg tggtttctga     1320

gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     1380

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     1440

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     1500

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     1560

accactgacc tgggacagtc aggtgagtat ctcagggatc cagacatggg gatatgggag     1620

gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttcag aattcgccgc     1680

caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc tggtcaccaa     1740

ttctgaagtg cagctggtgg aatctggtgg tggactggtt cagcctggtg gcagcctgag     1800

actgtcttgt gctgtgtctg gcattgacct gtctggctac tacatgaact gggtcagaca     1860

ggcccctggc aaaggcctgg aatgggttgg agtgattggc atcaatgggg ccacctacta     1920

tgccagctgg gccaagggca gattcaccat cagcagagac aacagcaaga ccacagtgta     1980

cctgcagatg aactccctga gagctgagga tacagctgtg tacttctgtg ccagagggga     2040

tatctggggc cagggcacac tggttacagt gtcctctgcc agcacaaagg gcccctctgt     2100

ttttccactg gctcccagca gcaagagcac cagtggtgga acagctgccc tgggctgtct     2160

ggtcaaggat tacttccctg agcctgtgac tgtgtcctgg aactctggtg cactgacctc     2220

tggggtgcac acctttccag ctgtgctgca gtcctctggc ctgtactctc tgtcctctgt     2280

ggtcacagtg cctagctcta gcctgggcac ccagacctac atctgcaatg tgaaccacaa     2340

gcctagcaac accaaagtgg atgccagagt ggaacccaag agctgtgaca agacccacac     2400

ctgtcctcca tgtcctgctc cagaactgct tggaggccct tctgtgttcc tgtttcctcc     2460

aaagcctaag gacaccctga tgatcagcag aacccctgaa gtgacctgtg tggtggttga     2520

tgtgtcccat gaggacccag aagtgaagtt caattggtat gtggatgggg ttgaagtgca     2580

caatgccaag accaagccta gggaagaaca gtatgccagc acctacagag tggtgtctgt     2640

gctgacagtg ctgcaccagg actggctgaa tggcaaagag tacaagtgca aggtgtccaa     2700

caaggccctg cctgctccta ttgagaaaac catctccaag gccaaggggc agcccagaga     2760

acctcaggtt tacaccctgc cacctagcag agaagagatg accaagaacc aggtgtccct     2820

gacctgcctg gttaagggct tctacccctc tgacattgct gtggaatggg agagcaatgg     2880

ccagccagag aacaactaca agacaacccc tcctgtgctg gactctgatg gctcattctt     2940

cctgtacagc aagctgactg tggacaagag cagatggcag cagggcaatg tgttcagctg     3000

ctctgtgatg catgaggccc tgcacaacca ctacacccag aaaagcctgt ctctgagccc     3060

tggcaagaga aagagaagag gctctggaga aggcagaggc tccctgctga catgtgggga     3120

tgttgaagag aatcctgggc ctatgtatag gatgcaactg ctcctcctga ttgctctgag     3180

cctggctctt gtgaccaact ctcaggttct gacacagagc cctagcagcc tgtctgcttc     3240

tgtgggagac agagtgacca tcaactgcca ggcctctcag tctgtgtacc acaacaccta     3300

cctggcctgg tatcagcaaa agcctggcaa ggtgcccaag cagctgatct atgatgcctc     3360

tacactggca tcaggggtgc cctccagatt ttctggctct ggatctggca ctgacttcac     3420

cctgaccatc agtagcctgc agcctgaaga tgtggccacc tattactgcc tgggcagcta     3480

tgactgcacc aatggggact gctttgtgtt tggtggtggc accaaggtgg aaatcaagag     3540

aacagtggct gccccatctg tgttcatctt cccaccatct gatgaacagc tgaagagtgg     3600

cacagcctct gttgtgtgcc tgctgaacaa cttctaccct agagaagcca aggtgcagtg     3660

gaaggtggac aatgccctgc agtctggcaa cagccaagaa tctgtgacag agcaggactc     3720

caaggattcc acctacagcc tgagcagcac cctgacactg agcaaggctg actatgagaa     3780

gcacaaagtg tatgcctgtg aagtgacaca ccagggactg agcagcccag tgaccaagag     3840

cttcaacagg ggagagtgct gataactcga ggacggggtg aactacgcct gaggatccga     3900

tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc     3960

tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc     4020

a                                                                     4021


<210>  295
<211>  4490
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  295
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga aggctcagag gcacacagga gtttctgggc tcaccctgcc cccttccaac      240

ccctcagttc ccatcctcca gcagctgttt gtgtgctgcc tctgaagtcc acactgaaca      300

aacttcagcc tactcatgtc cctaaaatgg gcaaacattg caagcagcaa acagcaaaca      360

cacagccctc cctgcctgct gaccttggag ctggggcaga ggtcagagac ctctctgggc      420

ccatgccacc tccaacatcc actcgacccc ttggaatttc ggtggagagg agcagaggtt      480

gtcctggcgt ggtttaggta gtgtgagagg gccactacgg gtttaggctg cccatgtaag      540

gaggcaaggc ctggggacac ccgagatgcc tggttataat taacccagac atgtggctgc      600

cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt ggatcccact      660

acgggtttag gctgcccatg taaggaggca aggcctgggg acacccgaga tgcctggtta      720

taattaaccc agacatgtgg ctgccccccc cccccccaac acctgctgcc tctaaaaata      780

accctgtccc tggtggatcc cactacgggt ttaggctgcc catgtaagga ggcaaggcct      840

ggggacaccc gagatgcctg gttataatta acccagacat gtggctgccc cccccccccc      900

caacacctgc tgcctctaaa aataaccctg tccctggtgg atcccctgca tgcgaagatc      960

ttcgaacaag gctgtggggg actgagggca ggctgtaaca ggcttggggg ccagggctta     1020

tacgtgcctg ggactcccaa agtattactg ttccatgttc ccggcgaagg gccagctgtc     1080

ccccgccagc tagactcagc acttagttta ggaaccagtg agcaagtcag cccttggggc     1140

agcccataca aggccatggg gctgggcaag ctgcacgcct gggtccgggg tgggcacggt     1200

gcccgggcaa cgagctgaaa gctcatctgc tctcaggggc ccctccctgg ggacagcccc     1260

tcctggctag tcacaccctg taggctcctc tatataaccc aggggcacag gggctgccct     1320

cattctacca ccacctccac agcacagaca gacactcagg agccagccag cgtcgagatc     1380

ttgctaccag tggaacagcc actaaggatt ctgcagtgag agcagagggc cagctaagtg     1440

gtactctccc agagactgtc tgactcacgc caccccctcc accttggaca caggacgctg     1500

tggtttctga gccaggtaca gtgactcctt tcggtaagtg cagtggaagc tgtacactgc     1560

ccaggcaaag cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc     1620

ccctgtttgc tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc     1680

cgttgcccct ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc     1740

ttcaggcacc accactgacc tgggacagtc aggtgagtat ctcagggatc cagacatggg     1800

gatatgggag gtgcctctga tcccagggct cactgtgggt ctctctgttc acaggttcag     1860

aattcgccgc caccatgtac agaatgcagc tgctgctgct cattgccctg tctctggccc     1920

tggtcaccaa ttctgaagtg cagctggtgg aatctggtgg tggactggtt cagcctggtg     1980

gcagcctgag actgtcttgt gctgtgtctg gcattgacct gtctggctac tacatgaact     2040

gggtcagaca ggcccctggc aaaggcctgg aatgggttgg agtgattggc atcaatgggg     2100

ccacctacta tgccagctgg gccaagggca gattcaccat cagcagagac aacagcaaga     2160

ccacagtgta cctgcagatg aactccctga gagctgagga tacagctgtg tacttctgtg     2220

ccagagggga tatctggggc cagggcacac tggttacagt gtcctctgcc agcacaaagg     2280

gcccctctgt ttttccactg gctcccagca gcaagagcac cagtggtgga acagctgccc     2340

tgggctgtct ggtcaaggat tacttccctg agcctgtgac tgtgtcctgg aactctggtg     2400

cactgacctc tggggtgcac acctttccag ctgtgctgca gtcctctggc ctgtactctc     2460

tgtcctctgt ggtcacagtg cctagctcta gcctgggcac ccagacctac atctgcaatg     2520

tgaaccacaa gcctagcaac accaaagtgg atgccagagt ggaacccaag agctgtgaca     2580

agacccacac ctgtcctcca tgtcctgctc cagaactgct tggaggccct tctgtgttcc     2640

tgtttcctcc aaagcctaag gacaccctga tgatcagcag aacccctgaa gtgacctgtg     2700

tggtggttga tgtgtcccat gaggacccag aagtgaagtt caattggtat gtggatgggg     2760

ttgaagtgca caatgccaag accaagccta gggaagaaca gtatgccagc acctacagag     2820

tggtgtctgt gctgacagtg ctgcaccagg actggctgaa tggcaaagag tacaagtgca     2880

aggtgtccaa caaggccctg cctgctccta ttgagaaaac catctccaag gccaaggggc     2940

agcccagaga acctcaggtt tacaccctgc cacctagcag agaagagatg accaagaacc     3000

aggtgtccct gacctgcctg gttaagggct tctacccctc tgacattgct gtggaatggg     3060

agagcaatgg ccagccagag aacaactaca agacaacccc tcctgtgctg gactctgatg     3120

gctcattctt cctgtacagc aagctgactg tggacaagag cagatggcag cagggcaatg     3180

tgttcagctg ctctgtgatg catgaggccc tgcacaacca ctacacccag aaaagcctgt     3240

ctctgagccc tggcaagaga aagagaagag gctctggaga aggcagaggc tccctgctga     3300

catgtgggga tgttgaagag aatcctgggc ctatgtatag gatgcaactg ctcctcctga     3360

ttgctctgag cctggctctt gtgaccaact ctcaggttct gacacagagc cctagcagcc     3420

tgtctgcttc tgtgggagac agagtgacca tcaactgcca ggcctctcag tctgtgtacc     3480

acaacaccta cctggcctgg tatcagcaaa agcctggcaa ggtgcccaag cagctgatct     3540

atgatgcctc tacactggca tcaggggtgc cctccagatt ttctggctct ggatctggca     3600

ctgacttcac cctgaccatc agtagcctgc agcctgaaga tgtggccacc tattactgcc     3660

tgggcagcta tgactgcacc aatggggact gctttgtgtt tggtggtggc accaaggtgg     3720

aaatcaagag aacagtggct gccccatctg tgttcatctt cccaccatct gatgaacagc     3780

tgaagagtgg cacagcctct gttgtgtgcc tgctgaacaa cttctaccct agagaagcca     3840

aggtgcagtg gaaggtggac aatgccctgc agtctggcaa cagccaagaa tctgtgacag     3900

agcaggactc caaggattcc acctacagcc tgagcagcac cctgacactg agcaaggctg     3960

actatgagaa gcacaaagtg tatgcctgtg aagtgacaca ccagggactg agcagcccag     4020

tgaccaagag cttcaacagg ggagagtgct gataactcga ggacggggtg aactacgcct     4080

gaggatccga tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc     4140

atctgacttc tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt     4200

tgtgtctctc actcggcggc cgcccgagtt taattggttt atagaactct tcaagctagc     4260

gaagcaattc gttgatctga atttcgacca cccataatac ccattaccct ggtagataag     4320

tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc     4380

tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc     4440

tttgcccggg cggcctcagt gagcgagcga gcgcgcagcc ttaattaacc                4490


<210>  296
<211>  3725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  296
taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc tgcctgctga       60

ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg ctcccgtttg      120

acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc ctctcccaga      180

acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct ataaggcgag      240

gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag ctgctaagtt      300

tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca gtgcccagaa      360

aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg gcagggggag      420

gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa gatcttcgaa      480

caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg cttatacgtg      540

cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc tgtcccccgc      600

cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg gggcagccca      660

tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca cggtgcccgg      720

gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag cccctcctgg      780

ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg ccctcattct      840

accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga gatcttgcta      900

ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta agtggtactc      960

tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac gctgtggttt     1020

ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc     1080

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt     1140

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc     1200

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg     1260

caccaccact gacctgggac agtcaggtga gtatctcagg gatccagaca tggggatatg     1320

ggaggtgcct ctgatcccag ggctcactgt gggtctctct gttcacaggt tcagaattcg     1380

ccgccaccat gtacagaatg cagctgctgc tgctcattgc cctgtctctg gccctggtca     1440

ccaattctga agtgcagctg gtggaatctg gtggtggact ggttcagcct ggtggcagcc     1500

tgagactgtc ttgtgctgtg tctggcattg acctgtctgg ctactacatg aactgggtca     1560

gacaggcccc tggcaaaggc ctggaatggg ttggagtgat tggcatcaat ggggccacct     1620

actatgccag ctgggccaag ggcagattca ccatcagcag agacaacagc aagaccacag     1680

tgtacctgca gatgaactcc ctgagagctg aggatacagc tgtgtacttc tgtgccagag     1740

gggatatctg gggccagggc acactggtta cagtgtcctc tgccagcaca aagggcccct     1800

ctgtttttcc actggctccc agcagcaaga gcaccagtgg tggaacagct gccctgggct     1860

gtctggtcaa ggattacttc cctgagcctg tgactgtgtc ctggaactct ggtgcactga     1920

cctctggggt gcacaccttt ccagctgtgc tgcagtcctc tggcctgtac tctctgtcct     1980

ctgtggtcac agtgcctagc tctagcctgg gcacccagac ctacatctgc aatgtgaacc     2040

acaagcctag caacaccaaa gtggatgcca gagtggaacc caagagctgt gacaagaccc     2100

acacctgtcc tccatgtcct gctccagaac tgcttggagg cccttctgtg ttcctgtttc     2160

ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc tgtgtggtgg     2220

ttgatgtgtc ccatgaggac ccagaagtga agttcaattg gtatgtggat ggggttgaag     2280

tgcacaatgc caagaccaag cctagggaag aacagtatgc cagcacctac agagtggtgt     2340

ctgtgctgac agtgctgcac caggactggc tgaatggcaa agagtacaag tgcaaggtgt     2400

ccaacaaggc cctgcctgct cctattgaga aaaccatctc caaggccaag gggcagccca     2460

gagaacctca ggtttacacc ctgccaccta gcagagaaga gatgaccaag aaccaggtgt     2520

ccctgacctg cctggttaag ggcttctacc cctctgacat tgctgtggaa tgggagagca     2580

atggccagcc agagaacaac tacaagacaa cccctcctgt gctggactct gatggctcat     2640

tcttcctgta cagcaagctg actgtggaca agagcagatg gcagcagggc aatgtgttca     2700

gctgctctgt gatgcatgag gccctgcaca accactacac ccagaaaagc ctgtctctga     2760

gccctggcaa gagaaagaga agaggctctg gagaaggcag aggctccctg ctgacatgtg     2820

gggatgttga agagaatcct gggcctatgt ataggatgca actgctcctc ctgattgctc     2880

tgagcctggc tcttgtgacc aactctcagg ttctgacaca gagccctagc agcctgtctg     2940

cttctgtggg agacagagtg accatcaact gccaggcctc tcagtctgtg taccacaaca     3000

cctacctggc ctggtatcag caaaagcctg gcaaggtgcc caagcagctg atctatgatg     3060

cctctacact ggcatcaggg gtgccctcca gattttctgg ctctggatct ggcactgact     3120

tcaccctgac catcagtagc ctgcagcctg aagatgtggc cacctattac tgcctgggca     3180

gctatgactg caccaatggg gactgctttg tgtttggtgg tggcaccaag gtggaaatca     3240

agagaacagt ggctgcccca tctgtgttca tcttcccacc atctgatgaa cagctgaaga     3300

gtggcacagc ctctgttgtg tgcctgctga acaacttcta ccctagagaa gccaaggtgc     3360

agtggaaggt ggacaatgcc ctgcagtctg gcaacagcca agaatctgtg acagagcagg     3420

actccaagga ttccacctac agcctgagca gcaccctgac actgagcaag gctgactatg     3480

agaagcacaa agtgtatgcc tgtgaagtga cacaccaggg actgagcagc ccagtgacca     3540

agagcttcaa caggggagag tgctgataac tcgaggacgg ggtgaactac gcctgaggat     3600

ccgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt gagcatctga     3660

cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat tttttgtgtc     3720

tctca                                                                 3725


<210>  297
<211>  4194
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct; vector antibody

<400>  297
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga taaaatgggc aaacattgca agcagcaaac agcaaacaca cagccctccc      240

tgcctgctga ccttggagct ggggcagagg tcagagacct ctctgagagg ggtacccggg      300

ctcccgtttg acccaagctt cctgagctct cctcccattc ccctttttgg agtcctcctc      360

ctctcccaga acccagtaat aagtgggctc ctccctggcc tggacccccg tggtaaccct      420

ataaggcgag gcagctgctg tctgaggcag ggaggggctg gtgtgggagg ctaagggcag      480

ctgctaagtt tagggtggct ccttctctct tcttagagac aacaggtggc tggggcctca      540

gtgcccagaa aagaaaatgt cttagaggta tcggcatggg cctggaggag gggggacagg      600

gcagggggag gcatcttcct caggacatcg ggtcctagag ggagcggccc tgcatgcgaa      660

gatcttcgaa caaggctgtg ggggactgag ggcaggctgt aacaggcttg ggggccaggg      720

cttatacgtg cctgggactc ccaaagtatt actgttccat gttcccggcg aagggccagc      780

tgtcccccgc cagctagact cagcacttag tttaggaacc agtgagcaag tcagcccttg      840

gggcagccca tacaaggcca tggggctggg caagctgcac gcctgggtcc ggggtgggca      900

cggtgcccgg gcaacgagct gaaagctcat ctgctctcag gggcccctcc ctggggacag      960

cccctcctgg ctagtcacac cctgtaggct cctctatata acccaggggc acaggggctg     1020

ccctcattct accaccacct ccacagcaca gacagacact caggagccag ccagcgtcga     1080

gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta     1140

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac     1200

gctgtggttt ctgagccagg tacagtgact cctttcggta agtgcagtgg aagctgtaca     1260

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact     1320

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct     1380

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct     1440

cagcttcagg caccaccact gacctgggac agtcaggtga gtatctcagg gatccagaca     1500

tggggatatg ggaggtgcct ctgatcccag ggctcactgt gggtctctct gttcacaggt     1560

tcagaattcg ccgccaccat gtacagaatg cagctgctgc tgctcattgc cctgtctctg     1620

gccctggtca ccaattctga agtgcagctg gtggaatctg gtggtggact ggttcagcct     1680

ggtggcagcc tgagactgtc ttgtgctgtg tctggcattg acctgtctgg ctactacatg     1740

aactgggtca gacaggcccc tggcaaaggc ctggaatggg ttggagtgat tggcatcaat     1800

ggggccacct actatgccag ctgggccaag ggcagattca ccatcagcag agacaacagc     1860

aagaccacag tgtacctgca gatgaactcc ctgagagctg aggatacagc tgtgtacttc     1920

tgtgccagag gggatatctg gggccagggc acactggtta cagtgtcctc tgccagcaca     1980

aagggcccct ctgtttttcc actggctccc agcagcaaga gcaccagtgg tggaacagct     2040

gccctgggct gtctggtcaa ggattacttc cctgagcctg tgactgtgtc ctggaactct     2100

ggtgcactga cctctggggt gcacaccttt ccagctgtgc tgcagtcctc tggcctgtac     2160

tctctgtcct ctgtggtcac agtgcctagc tctagcctgg gcacccagac ctacatctgc     2220

aatgtgaacc acaagcctag caacaccaaa gtggatgcca gagtggaacc caagagctgt     2280

gacaagaccc acacctgtcc tccatgtcct gctccagaac tgcttggagg cccttctgtg     2340

ttcctgtttc ctccaaagcc taaggacacc ctgatgatca gcagaacccc tgaagtgacc     2400

tgtgtggtgg ttgatgtgtc ccatgaggac ccagaagtga agttcaattg gtatgtggat     2460

ggggttgaag tgcacaatgc caagaccaag cctagggaag aacagtatgc cagcacctac     2520

agagtggtgt ctgtgctgac agtgctgcac caggactggc tgaatggcaa agagtacaag     2580

tgcaaggtgt ccaacaaggc cctgcctgct cctattgaga aaaccatctc caaggccaag     2640

gggcagccca gagaacctca ggtttacacc ctgccaccta gcagagaaga gatgaccaag     2700

aaccaggtgt ccctgacctg cctggttaag ggcttctacc cctctgacat tgctgtggaa     2760

tgggagagca atggccagcc agagaacaac tacaagacaa cccctcctgt gctggactct     2820

gatggctcat tcttcctgta cagcaagctg actgtggaca agagcagatg gcagcagggc     2880

aatgtgttca gctgctctgt gatgcatgag gccctgcaca accactacac ccagaaaagc     2940

ctgtctctga gccctggcaa gagaaagaga agaggctctg gagaaggcag aggctccctg     3000

ctgacatgtg gggatgttga agagaatcct gggcctatgt ataggatgca actgctcctc     3060

ctgattgctc tgagcctggc tcttgtgacc aactctcagg ttctgacaca gagccctagc     3120

agcctgtctg cttctgtggg agacagagtg accatcaact gccaggcctc tcagtctgtg     3180

taccacaaca cctacctggc ctggtatcag caaaagcctg gcaaggtgcc caagcagctg     3240

atctatgatg cctctacact ggcatcaggg gtgccctcca gattttctgg ctctggatct     3300

ggcactgact tcaccctgac catcagtagc ctgcagcctg aagatgtggc cacctattac     3360

tgcctgggca gctatgactg caccaatggg gactgctttg tgtttggtgg tggcaccaag     3420

gtggaaatca agagaacagt ggctgcccca tctgtgttca tcttcccacc atctgatgaa     3480

cagctgaaga gtggcacagc ctctgttgtg tgcctgctga acaacttcta ccctagagaa     3540

gccaaggtgc agtggaaggt ggacaatgcc ctgcagtctg gcaacagcca agaatctgtg     3600

acagagcagg actccaagga ttccacctac agcctgagca gcaccctgac actgagcaag     3660

gctgactatg agaagcacaa agtgtatgcc tgtgaagtga cacaccaggg actgagcagc     3720

ccagtgacca agagcttcaa caggggagag tgctgataac tcgaggacgg ggtgaactac     3780

gcctgaggat ccgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt     3840

gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat     3900

tttttgtgtc tctcactcgg cggccgcccg agtttaattg gtttatagaa ctcttcaagc     3960

tagcgaagca attcgttgat ctgaatttcg accacccata atacccatta ccctggtaga     4020

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     4080

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     4140

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agccttaatt aacc           4194


