                         SEQUENCE LISTING

<110>  City of Hope
       Pichiorri, Flavia
       Williams, John
       Park, Miso
       Murtadha, Mariam
       Marcucci, Guido
 
<120>  BISPECIFIC ANTI-CD38-CD3 BINDERS

<130>  048440-786001WO

<150>  63/106,840
<151>  2020-10-28

<150>  63/261,944
<151>  2021-09-30

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Arg Ala Ser Gln Ser Ile Arg Ser Tyr Leu Asn 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  3

Gln Gln Thr Tyr Ser Asn Pro Pro Ile Thr 
1               5                   10  


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Gly Phe Thr Phe Asp Asp Tyr 
1               5           


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  5

Ser Trp Asn Ser Gly Ser 
1               5       


<210>  6
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Asp Met Ser Gly Tyr Gly His Tyr Gly Lys Tyr Gly Met Asp Val 
1               5                   10                  15  


<210>  7
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Thr Tyr Ser Asn Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  8
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Ser Gly Tyr Gly His Tyr Gly Lys Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  9

Ala Ala Ser Gly Gly Ala Gly Ser 
1               5               


<210>  10
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Gly Ala Val Pro Leu Ser Leu Tyr Gly Ala Gly Gly 
1               5                   10          


<210>  11
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  11

Ser Ser Gly Ala Ser Ala Ser Ala Ala Gly Gly Ser 
1               5                   10          


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Gly Arg Thr Phe Arg Asn Tyr 
1               5           


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  13

Thr Trp Val Gly Ala Ser 
1               5       


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Gly Arg Gly Ile Val Ala Gly Arg Ile Pro Ala Glu Tyr Ala Asp 
1               5                   10                  15  


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Gly Ser Gly Arg Thr Phe Arg Asn Tyr 
            20                  25                  30          


Pro Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Thr Trp Val Gly Ala Ser Thr Leu Tyr Ala Asp Phe Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Gly Arg Gly Ile Val Ala Gly Arg Ile Pro Ala Glu Tyr Ala 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120         


<210>  16
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Ser Gly Tyr Gly His Tyr Gly Lys Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Ala Ala Ser Gly Gly Ala Gly Ser Asp Val Gln Leu Gln 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                245                 250                 255     


Cys Thr Gly Ser Gly Arg Thr Phe Arg Asn Tyr Pro Met Ala Trp Phe 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Gly Ile Thr Trp 
        275                 280                 285             


Val Gly Ala Ser Thr Leu Tyr Ala Asp Phe Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ala Ala Gly Arg Gly 
                325                 330                 335     


Ile Val Ala Gly Arg Ile Pro Ala Glu Tyr Ala Asp Trp Gly Gln Gly 
            340                 345                 350         


Thr Gln Val Thr Val Ser Ser Gly Ala Val Pro Leu Ser Leu Tyr Gly 
        355                 360                 365             


Ala Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala 
    370                 375                 380                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
385                 390                 395                 400 


Arg Ser Tyr Leu Asn Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg 
                405                 410                 415     


Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
            420                 425                 430         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
        435                 440                 445             


Leu Gln Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Thr Tyr Ser 
    450                 455                 460                 


Asn Pro Pro Ile Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Arg 
465                 470                 475                 480 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
                485                 490                 495     


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            500                 505                 510         


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        515                 520                 525             


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    530                 535                 540                 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
545                 550                 555                 560 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                565                 570                 575     


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            580                 585     


<210>  17
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Ser Gly Tyr Gly His Tyr Gly Lys Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Ala Ala Ser Gly Gly Ala Gly Ser Asp Val Gln Leu Gln 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly His Ser Leu Arg Leu Ser 
                245                 250                 255     


Cys Val Gly Ser Gly Ser Arg Phe Asp Asn Tyr Ala Met Gly Trp Phe 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp 
        275                 280                 285             


Ser Ser Gly Thr Thr Arg Tyr Leu Asp Thr Val Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Tyr Gln 
                325                 330                 335     


Pro Arg Tyr Tyr Asp Ser Gly Asp Met Asp Gly Tyr Glu Tyr Asp Asn 
            340                 345                 350         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Ala Val Pro Leu 
        355                 360                 365             


Ser Leu Tyr Gly Ala Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ile 
    370                 375                 380                 


Leu Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
385                 390                 395                 400 


Ser Gln Ser Ile Arg Ser Tyr Leu Asn Trp Tyr Gln Gln Arg Thr Asn 
                405                 410                 415     


Gly Ser Pro Arg Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            420                 425                 430         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        435                 440                 445             


Thr Ile Asn Ser Leu Gln Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Gln 
    450                 455                 460                 


Gln Thr Tyr Ser Asn Pro Pro Ile Thr Phe Gly Ala Gly Thr Arg Leu 
465                 470                 475                 480 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
                485                 490                 495     


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
            500                 505                 510         


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
        515                 520                 525             


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
    530                 535                 540                 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
                565                 570                 575     


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            580                 585                 590 


<210>  18
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Ser Gly Tyr Gly His Tyr Gly Lys Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Ala Ala Ser Gly Gly Ala Gly Ser Asp Val Gln Leu Gln 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Thr Leu Ser 
                245                 250                 255     


Cys Thr Ala Ser Gly Leu Leu Phe Arg Leu Ala Ser Met Gly Trp Tyr 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile Ala Thr Ile Thr Val 
        275                 280                 285             


Gly Gly Lys Thr Asn Tyr Lys Asp Ser Val Gln Gly Arg Phe Ile Ile 
    290                 295                 300                 


Thr Arg Asp Asn Thr Gly Asp Asn Thr Lys Ser Thr Val Thr Leu Gln 
305                 310                 315                 320 


Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
                325                 330                 335     


Ala Ser Pro Ala Val Gly Ala Asp Thr Trp Gly Gln Gly Thr Arg Val 
            340                 345                 350         


Thr Val Ser Ser Gly Ala Val Pro Leu Ser Leu Tyr Gly Ala Gly Gly 
        355                 360                 365             


Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
    370                 375                 380                 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
385                 390                 395                 400 


Leu Asn Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
                405                 410                 415     


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
            420                 425                 430         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
        435                 440                 445             


Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Thr Tyr Ser Asn Pro Pro 
    450                 455                 460                 


Ile Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
465                 470                 475                 480 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                485                 490                 495     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            500                 505                 510         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        515                 520                 525             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    530                 535                 540                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
545                 550                 555                 560 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                565                 570                 575     


Ser Phe Asn Arg Gly Glu Cys 
            580             


<210>  19
<211>  586
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Ser Gly Tyr Gly His Tyr Gly Lys Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Ala Ala Ser Gly Gly Ala Gly Ser Asp Val Gln Leu Gln 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser 
                245                 250                 255     


Cys Thr Gly Ser Gly Arg Thr Phe Arg Asn Tyr Pro Met Ala Trp Phe 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Gly Ile Thr Trp 
        275                 280                 285             


Val Gly Ala Ser Thr Leu Tyr Ala Asp Phe Ala Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Ser Cys Ala Ala Gly Arg Gly 
                325                 330                 335     


Ile Val Ala Gly Arg Ile Pro Ala Glu Tyr Ala Asp Trp Gly Gln Gly 
            340                 345                 350         


Thr Gln Val Thr Val Ser Ser Ser Ser Gly Ala Ser Ala Ser Ala Ala 
        355                 360                 365             


Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala 
    370                 375                 380                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
385                 390                 395                 400 


Arg Ser Tyr Leu Asn Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg 
                405                 410                 415     


Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg 
            420                 425                 430         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser 
        435                 440                 445             


Leu Gln Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Thr Tyr Ser 
    450                 455                 460                 


Asn Pro Pro Ile Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Arg 
465                 470                 475                 480 


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
                485                 490                 495     


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            500                 505                 510         


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        515                 520                 525             


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    530                 535                 540                 


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
545                 550                 555                 560 


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                565                 570                 575     


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            580                 585     


<210>  20
<211>  590
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Ser Gly Tyr Gly His Tyr Gly Lys Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Ala Ala Ser Gly Gly Ala Gly Ser Asp Val Gln Leu Gln 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Leu Val Gln Ala Gly His Ser Leu Arg Leu Ser 
                245                 250                 255     


Cys Val Gly Ser Gly Ser Arg Phe Asp Asn Tyr Ala Met Gly Trp Phe 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Trp 
        275                 280                 285             


Ser Ser Gly Thr Thr Arg Tyr Leu Asp Thr Val Lys Gly Arg Phe Thr 
    290                 295                 300                 


Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr Leu Gln Met Asn Ser 
305                 310                 315                 320 


Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Arg Tyr Gln 
                325                 330                 335     


Pro Arg Tyr Tyr Asp Ser Gly Asp Met Asp Gly Tyr Glu Tyr Asp Asn 
            340                 345                 350         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ser Ser Gly Ala Ser 
        355                 360                 365             


Ala Ser Ala Ala Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ile 
    370                 375                 380                 


Leu Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
385                 390                 395                 400 


Ser Gln Ser Ile Arg Ser Tyr Leu Asn Trp Tyr Gln Gln Arg Thr Asn 
                405                 410                 415     


Gly Ser Pro Arg Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly 
            420                 425                 430         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        435                 440                 445             


Thr Ile Asn Ser Leu Gln Pro Asp Asp Glu Ala Asp Tyr Tyr Cys Gln 
    450                 455                 460                 


Gln Thr Tyr Ser Asn Pro Pro Ile Thr Phe Gly Ala Gly Thr Arg Leu 
465                 470                 475                 480 


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
                485                 490                 495     


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
            500                 505                 510         


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
        515                 520                 525             


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
    530                 535                 540                 


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
545                 550                 555                 560 


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
                565                 570                 575     


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            580                 585                 590 


<210>  21
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Gly Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Met Ser Gly Tyr Gly His Tyr Gly Lys Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Ala Ala Ser Gly Gly Ala Gly Ser Asp Val Gln Leu Gln 
225                 230                 235                 240 


Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly Ser Leu Thr Leu Ser 
                245                 250                 255     


Cys Thr Ala Ser Gly Leu Leu Phe Arg Leu Ala Ser Met Gly Trp Tyr 
            260                 265                 270         


Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile Ala Thr Ile Thr Val 
        275                 280                 285             


Gly Gly Lys Thr Asn Tyr Lys Asp Ser Val Gln Gly Arg Phe Ile Ile 
    290                 295                 300                 


Thr Arg Asp Asn Thr Gly Asp Asn Thr Lys Ser Thr Val Thr Leu Gln 
305                 310                 315                 320 


Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Thr 
                325                 330                 335     


Ala Ser Pro Ala Val Gly Ala Asp Thr Trp Gly Gln Gly Thr Arg Val 
            340                 345                 350         


Thr Val Ser Ser Ser Ser Gly Ala Ser Ala Ser Ala Ala Gly Gly Ser 
        355                 360                 365             


Asp Ile Gln Met Thr Gln Ser Pro Ile Leu Leu Ser Ala Ser Val Gly 
    370                 375                 380                 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser Tyr 
385                 390                 395                 400 


Leu Asn Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
                405                 410                 415     


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
            420                 425                 430         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Gln Pro 
        435                 440                 445             


Asp Asp Glu Ala Asp Tyr Tyr Cys Gln Gln Thr Tyr Ser Asn Pro Pro 
    450                 455                 460                 


Ile Thr Phe Gly Ala Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 
465                 470                 475                 480 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                485                 490                 495     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            500                 505                 510         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        515                 520                 525             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    530                 535                 540                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
545                 550                 555                 560 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                565                 570                 575     


Ser Phe Asn Arg Gly Glu Cys 
            580             


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Ser Arg Phe Asp Asn Tyr 
1               5       


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  23

Trp Ser Ser Gly Thr 
1               5   


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Tyr Gln Pro Arg Tyr Tyr Asp Ser Gly Asp Met Asp Gly Tyr Glu Tyr 
1               5                   10                  15      


Asp Asn 
        


<210>  25
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  25

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Ala Gly His 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Gly Ser Gly Ser Arg Phe Asp Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Trp Ser Ser Gly Thr Thr Arg Tyr Leu Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Tyr Gln Pro Arg Tyr Tyr Asp Ser Gly Asp Met Asp Gly 
            100                 105                 110         


Tyr Glu Tyr Asp Asn Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125     


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Leu Leu Phe Arg Leu Ala Ser 
1               5           


<210>  27
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  27

Asn Thr Gly Asp Asn Thr 
1               5       


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Ser Pro Ala Val Gly Ala Asp Thr 
1               5               


<210>  29
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  29

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Thr Ala Ser Gly Leu Leu Phe Arg Leu Ala 
            20                  25                  30          


Ser Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Ile 
        35                  40                  45              


Ala Thr Ile Thr Val Gly Gly Lys Thr Asn Tyr Lys Asp Ser Val Gln 
    50                  55                  60                  


Gly Arg Phe Ile Ile Thr Arg Asp Asn Thr Gly Asp Asn Thr Lys Ser 
65                  70                  75                  80  


Thr Val Thr Leu Gln Met Asn Arg Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Asn Thr Ala Ser Pro Ala Val Gly Ala Asp Thr Trp Gly 
            100                 105                 110         


Gln Gly Thr Arg Val Thr Val 
        115                 


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Ser Ser Ser Ser Gly Ala Ser Ala Ser Ala Ala Gly Gly Ser 
1               5                   10                  


<210>  31
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  31

Ser Ser Gly Ala Val Pro Leu Ser Leu Tyr Gly Ala Gly Gly 
1               5                   10                  


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Lys Ser Ser Gln Ser Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  33
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  33

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  34

Lys Gln Ser Tyr Ile Leu Arg Thr 
1               5               


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  35

Gly Tyr Thr Phe Thr Asn Tyr 
1               5           


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  36

Tyr Cys Gly Asp Gly Ser 
1               5       


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  37

Asp Trp Ala Gly Ser Tyr Phe Phe Asp Phe 
1               5                   10  


<210>  38
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ile Leu Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  39

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Cys Gly Asp Gly Ser Thr Lys Phe Asn Glu Gln Phe 
    50                  55                  60                  


Lys Asp Arg Thr Thr Leu Ser Ala Asp His Ser Lys Thr Gln Ala Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Trp Ala Gly Ser Tyr Phe Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  40

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ile Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Cys Gly Asp Gly Ser Thr Lys Phe Asn Glu Gln Phe 
    50                  55                  60                  


Lys Asp Arg Thr Thr Leu Thr Ala Asp His Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Trp Ala Gly Ser Tyr Phe Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  42
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  42

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Asn 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Ile Leu Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  43
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  43

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Tyr Val His Trp Leu Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Leu Leu Ser Ser Leu Thr Ser Ala Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Thr Arg Asp Ala Gly Tyr Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


