                         SEQUENCE LISTING

<110>  Memorial Sloan Kettering Cancer Center
 
<120>  CELLS WITH CD70 KNOCKOUT AND USES FOR IMMUNOTHERAPY

<130>  072734.1281

<150>  US 63/105,603
<151>  2020-10-26

<160>  82    

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ile Met His 
1               5                   10              


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr 
1               5                   10  


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  5
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Tyr Asp Ala Ser Asn Arg Ala Thr 
1               5               


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Gln Gln Arg Thr Asn Trp Pro Leu Thr 
1               5                   


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  9
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg 
    210                 215                 220                 


Thr Asn Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


<210>  10
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  11
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Arg Leu Leu Leu Ala Leu Asn Leu Phe Pro Ser Ile Gln Val 
1               5                   10                  15      


Thr Gly Asn Lys Ile Leu Val Lys Gln Ser Pro Met Leu Val Ala Tyr 
            20                  25                  30          


Asp Asn Ala Val Asn Leu Ser Cys Lys Tyr Ser Tyr Asn Leu Phe Ser 
        35                  40                  45              


Arg Glu Phe Arg Ala Ser Leu His Lys Gly Leu Asp Ser Ala Val Glu 
    50                  55                  60                  


Val Cys Val Val Tyr Gly Asn Tyr Ser Gln Gln Leu Gln Val Tyr Ser 
65                  70                  75                  80  


Lys Thr Gly Phe Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr 
                85                  90                  95      


Phe Tyr Leu Gln Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys 
            100                 105                 110         


Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser 
        115                 120                 125             


Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro 
    130                 135                 140                 


Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly 
145                 150                 155                 160 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                165                 170                 175     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            180                 185                 190         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        195                 200                 205             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215                 220 


<210>  12
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Trp Lys Ala Leu Phe Thr Ala Ala Ile Leu Gln Ala Gln Leu 
1               5                   10                  15      


Pro Ile Thr Glu Ala Gln Ser Phe Gly Leu Leu Asp Pro Lys Leu Cys 
            20                  25                  30          


Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu Thr Ala 
        35                  40                  45              


Leu Phe Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
    50                  55                  60                  


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
65                  70                  75                  80  


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
                85                  90                  95      


Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            100                 105                 110         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        115                 120                 125             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    130                 135                 140                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
145                 150                 155                 160 


Leu Pro Pro Arg 
                


<210>  13
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  14
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
1               5                   10                  15      


Asp Val Leu Asp Lys Arg 
            20          


<210>  15
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
cagaaccagc tctataacga gctcaatcta ggacgaagag aggagtacga tgttttggac       60

aagaga                                                                  66


<210>  16
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Phe 
1               5                   10                  15      


Asp Val Leu Asp Lys Arg 
            20          


<210>  17
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
cagaaccagc tctttaacga gctcaatcta ggacgaagag aggagttcga tgttttggac       60

aagaga                                                                  66


<210>  18
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
1               5                   10                  15      


Tyr Ser Glu Ile Gly Met Lys 
            20              


<210>  19
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19
caggaaggcc tgtacaatga actgcagaaa gataagatgg cggaggccta cagtgagatt       60

gggatgaaa                                                               69


<210>  20
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala 
1               5                   10                  15      


Phe Ser Glu Ile Gly Met Lys 
            20              


<210>  21
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
caggaaggcc tgttcaatga actgcagaaa gataagatgg cggaggcctt cagtgagatt       60

gggatgaaa                                                               69


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
1               5                   10                  15      


Asp Ala Leu His Met Gln 
            20          


<210>  23
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
cacgatggcc tttaccaggg tctcagtaca gccaccaagg acacctacga cgcccttcac       60

atgcag                                                                  66


<210>  24
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
1               5                   10                  15      


Asp Ala Leu His Met Gln 
            20          


<210>  25
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
cacgatggcc ttttccaggg gctcagtaca gccaccaagg acaccttcga cgcccttcac       60

atgcag                                                                  66


<210>  26
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  27
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gagacgtggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgttcaat      180

gaactgcaga aagataagat ggcggaggcc ttcagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggccttttc caggggctca gtacagccac caaggacacc      300

ttcgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  28
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc       60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc      120

tcc                                                                    123


<210>  29
<211>  218
<212>  PRT
<213>  Mus musculus

<400>  29

Met Thr Leu Arg Leu Leu Phe Leu Ala Leu Asn Phe Phe Ser Val Gln 
1               5                   10                  15      


Val Thr Glu Asn Lys Ile Leu Val Lys Gln Ser Pro Leu Leu Val Val 
            20                  25                  30          


Asp Ser Asn Glu Val Ser Leu Ser Cys Arg Tyr Ser Tyr Asn Leu Leu 
        35                  40                  45              


Ala Lys Glu Phe Arg Ala Ser Leu Tyr Lys Gly Val Asn Ser Asp Val 
    50                  55                  60                  


Glu Val Cys Val Gly Asn Gly Asn Phe Thr Tyr Gln Pro Gln Phe Arg 
65                  70                  75                  80  


Ser Asn Ala Glu Phe Asn Cys Asp Gly Asp Phe Asp Asn Glu Thr Val 
                85                  90                  95      


Thr Phe Arg Leu Trp Asn Leu His Val Asn His Thr Asp Ile Tyr Phe 
            100                 105                 110         


Cys Lys Ile Glu Phe Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Arg 
        115                 120                 125             


Ser Asn Gly Thr Ile Ile His Ile Lys Glu Lys His Leu Cys His Thr 
    130                 135                 140                 


Gln Ser Ser Pro Lys Leu Phe Trp Ala Leu Val Val Val Ala Gly Val 
145                 150                 155                 160 


Leu Phe Cys Tyr Gly Leu Leu Val Thr Val Ala Leu Cys Val Ile Trp 
                165                 170                 175     


Thr Asn Ser Arg Arg Asn Arg Leu Leu Gln Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Leu Thr Arg Lys Pro Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Ala Arg Asp Phe Ala Ala Tyr Arg Pro 
    210                 215             


<210>  30
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  31
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln 
145                 150                 155                 160 


Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro 
            180                 185                 190         


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
        195                 200                 205             


Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg 
    210                 215                 220                 


Thr Asn Trp Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
225                 230                 235                 240 


Ala Ala Ala Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu 
                245                 250                 255     


Lys Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro 
            260                 265                 270         


Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val 
        275                 280                 285             


Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe 
    290                 295                 300                 


Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp 
305                 310                 315                 320 


Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr 
                325                 330                 335     


Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val 
            340                 345                 350         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        355                 360                 365             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    370                 375                 380                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
385                 390                 395                 400 


Arg Lys Asn Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys 
                405                 410                 415     


Met Ala Glu Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            420                 425                 430         


Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys 
        435                 440                 445             


Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460         


<210>  32
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt taccttcagt agctatatta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagaaa caaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatacg      300

gatggctacg attttgacta ctggggccag ggaaccctgg tcaccgtctc ctcaggtgga      360

ggtggatcag gtggaggtgg atctggtgga ggtggatctg aaattgtgtt gacacagtct      420

ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag ggccagtcag      480

agtgttagca gctacttagc ctggtaccaa cagaaacctg gccaggctcc caggctcctc      540

atctatgatg catccaacag ggccactggc atcccagcca ggttcagtgg cagtgggtct      600

gggacagact tcactctcac catcagcagc ctagagcctg aagattttgc agtttattac      660

tgtcagcagc gtaccaactg gccgctcact ttcggcggag ggaccaaggt ggagatcaaa      720

gcggccgcaa ttgaagttat gtatcctcct ccttacctag acaatgagaa gagcaatgga      780

accattatcc atgtgaaagg gaaacacctt tgtccaagtc ccctatttcc cggaccttct      840

aagccctttt gggtgctggt ggtggttggt ggagtcctgg cttgctatag cttgctagta      900

acagtggcct ttattatttt ctgggtgagg agtaagagga gcaggctcct gcacagtgac      960

tacatgaaca tgactccccg ccgccccggg cccacccgca agcattacca gccctatgcc     1020

ccaccacgcg acttcgcagc ctatcgctcc agagtgaagt tcagcaggag cgcagacgcc     1080

cccgcgtacc agcagggcca gaaccagctc tataacgagc tcaatctagg acgaagagag     1140

gagtacgatg ttttggacaa gagacgtggc cgggaccctg agatgggggg aaagccgaga     1200

aggaagaacc ctcaggaagg cctgttcaat gaactgcaga aagataagat ggcggaggcc     1260

ttcagtgaga ttgggatgaa aggcgagcgc cggaggggca aggggcacga tggccttttc     1320

caggggctca gtacagccac caaggacacc ttcgacgccc ttcacatgca ggccctgccc     1380

cctcgc                                                                1386


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  34

Met Tyr Ser Met Gln Leu Ala Ser Cys Val Thr Leu Thr Leu Val Leu 
1               5                   10                  15      


Leu Val Asn Ser 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Met Glu Thr Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  38
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala 
        


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Ser Ser Ala Tyr Ser 
1               5                   10                  15      


<210>  40
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Met Asp Ser Lys Gly Ser Ser Gln Lys Gly Ser Arg Leu Leu Leu Leu 
1               5                   10                  15      


Leu Val Val Ser Asn Leu Leu Leu Cys Gln Gly Val Val Ser 
            20                  25                  30  


<210>  41
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  41

Ile Gln Asn Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser 
1               5                   10                  15      


Ser Asp Lys Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn 
            20                  25                  30          


Val Ser Gln Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val 
        35                  40                  45              


Leu Asp Met Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp 
    50                  55                  60                  


Ser Asn Lys Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile 
65                  70                  75                  80  


Ile Pro Glu Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val 
                85                  90                  95      


Lys Leu Val Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln 
            100                 105                 110         


Asn Leu Ser Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly 
        115                 120                 125             


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
    130                 135                 140 


<210>  42
<211>  4627
<212>  DNA
<213>  Homo sapiens

<400>  42
atatccagaa ccctgaccct gccgtgtacc agctgagaga ctctaaatcc agtgacaagt       60

ctgtctgcct attcaccgat tttgattctc aaacaaatgt gtcacaaagt aaggattctg      120

atgtgtatat cacagacaaa actgtgctag acatgaggtc tatggacttc aagagcaaca      180

gtgctgtggc ctggagcaac aaatctgact ttgcatgtgc aaacgccttc aacaacagca      240

ttattccaga agacaccttc ttccccagcc caggtaaggg cagctttggt gccttcgcag      300

gctgtttcct tgcttcagga atggccaggt tctgcccaga gctctggtca atgatgtcta      360

aaactcctct gattggtggt ctcggcctta tccattgcca ccaaaaccct ctttttacta      420

agaaacagtg agccttgttc tggcagtcca gagaatgaca cgggaaaaaa gcagatgaag      480

agaaggtggc aggagagggc acgtggccca gcctcagtct ctccaactga gttcctgcct      540

gcctgccttt gctcagactg tttgcccctt actgctcttc taggcctcat tctaagcccc      600

ttctccaagt tgcctctcct tatttctccc tgtctgccaa aaaatctttc ccagctcact      660

aagtcagtct cacgcagtca ctcattaacc caccaatcac tgattgtgcc ggcacatgaa      720

tgcaccaggt gttgaagtgg aggaattaaa aagtcagatg aggggtgtgc ccagaggaag      780

caccattcta gttgggggag cccatctgtc agctgggaaa agtccaaata acttcagatt      840

ggaatgtgtt ttaactcagg gttgagaaaa cagctacctt caggacaaaa gtcagggaag      900

ggctctctga agaaatgcta cttgaagata ccagccctac caagggcagg gagaggaccc      960

tatagaggcc tgggacagga gctcaatgag aaaggagaag agcagcaggc atgagttgaa     1020

tgaaggaggc agggccgggt cacagggcct tctaggccat gagagggtag acagtattct     1080

aaggacgcca gaaagctgtt gatcggcttc aagcagggga gggacaccta atttgctttt     1140

cttttttttt tttttttttt tttttttttt tgagatggag ttttgctctt gttgcccagg     1200

ctggagtgca atggtgcatc ttggctcact gcaacctccg cctcccaggt tcaagtgatt     1260

ctcctgcctc agcctcccga gtagctgaga ttacaggcac ccgccaccat gcctggctaa     1320

ttttttgtat ttttagtaga gacagggttt cactatgttg gccaggctgg tctcgaactc     1380

ctgacctcag gtgatccacc cgcttcagcc tcccaaagtg ctgggattac aggcgtgagc     1440

caccacaccc ggcctgcttt tcttaaagat caatctgagt gctgtacgga gagtgggttg     1500

taagccaaga gtagaagcag aaagggagca gttgcagcag agagatgatg gaggcctggg     1560

cagggtggtg gcagggaggt aaccaacacc attcaggttt caaaggtaga accatgcagg     1620

gatgagaaag caaagagggg atcaaggaag gcagctggat tttggcctga gcagctgagt     1680

caatgatagt gccgtttact aagaagaaac caaggaaaaa atttggggtg cagggatcaa     1740

aactttttgg aacatatgaa agtacgtgtt tatactcttt atggcccttg tcactatgta     1800

tgcctcgctg cctccattgg actctagaat gaagccaggc aagagcaggg tctatgtgtg     1860

atggcacatg tggccagggt catgcaacat gtactttgta caaacagtgt atattgagta     1920

aatagaaatg gtgtccagga gccgaggtat cggtcctgcc agggccaggg gctctcccta     1980

gcaggtgctc atatgctgta agttccctcc agatctctcc acaaggaggc atggaaaggc     2040

tgtagttgtt cacctgccca agaactagga ggtctggggt gggagagtca gcctgctctg     2100

gatgctgaaa gaatgtctgt ttttcctttt agaaagttcc tgtgatgtca agctggtcga     2160

gaaaagcttt gaaacaggta agacaggggt ctagcctggg tttgcacagg attgcggaag     2220

tgatgaaccc gcaataaccc tgcctggatg agggagtggg aagaaattag tagatgtggg     2280

aatgaatgat gaggaatgga aacagcggtt caagacctgc ccagagctgg gtggggtctc     2340

tcctgaatcc ctctcaccat ctctgacttt ccattctaag cactttgagg atgagtttct     2400

agcttcaata gaccaaggac tctctcctag gcctctgtat tcctttcaac agctccactg     2460

tcaagagagc cagagagagc ttctgggtgg cccagctgtg aaatttctga gtcccttagg     2520

gatagcccta aacgaaccag atcatcctga ggacagccaa gaggttttgc cttctttcaa     2580

gacaagcaac agtactcaca taggctgtgg gcaatggtcc tgtctctcaa gaatcccctg     2640

ccactcctca cacccaccct gggcccatat tcatttccat ttgagttgtt cttattgagt     2700

catccttcct gtggtagcgg aactcactaa ggggcccatc tggacccgag gtattgtgat     2760

gataaattct gagcacctac cccatcccca gaagggctca gaaataaaat aagagccaag     2820

tctagtcggt gtttcctgtc ttgaaacaca atactgttgg ccctggaaga atgcacagaa     2880

tctgtttgta aggggatatg cacagaagct gcaagggaca ggaggtgcag gagctgcagg     2940

cctcccccac ccagcctgct ctgccttggg gaaaaccgtg ggtgtgtcct gcaggccatg     3000

caggcctggg acatgcaagc ccataaccgc tgtggcctct tggttttaca gatacgaacc     3060

taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa gtggccgggt     3120

ttaatctgct catgacgctg cggctgtggt ccagctgagg tgaggggcct tgaagctggg     3180

agtggggttt agggacgcgg gtctctgggt gcatcctaag ctctgagagc aaacctccct     3240

gcagggtctt gcttttaagt ccaaagcctg agcccaccaa actctcctac ttcttcctgt     3300

tacaaattcc tcttgtgcaa taataatggc ctgaaacgct gtaaaatatc ctcatttcag     3360

ccgcctcagt tgcacttctc ccctatgagg taggaagaac agttgtttag aaacgaagaa     3420

actgaggccc cacagctaat gagtggagga agagagacac ttgtgtacac cacatgcctt     3480

gtgttgtact tctctcaccg tgtaacctcc tcatgtcctc tctccccagt acggctctct     3540

tagctcagta gaaagaagac attacactca tattacaccc caatcctggc tagagtctcc     3600

gcaccctcct cccccagggt ccccagtcgt cttgctgaca actgcatcct gttccatcac     3660

catcaaaaaa aaactccagg ctgggtgcgg gggctcacac ctgtaatccc agcactttgg     3720

gaggcagagg caggaggagc acaggagctg gagaccagcc tgggcaacac agggagaccc     3780

cgcctctaca aaaagtgaaa aaattaacca ggtgtggtgc tgcacacctg tagtcccagc     3840

tacttaagag gctgagatgg gaggatcgct tgagccctgg aatgttgagg ctacaatgag     3900

ctgtgattgc gtcactgcac tccagcctgg aagacaaagc aagatcctgt ctcaaataat     3960

aaaaaaaata agaactccag ggtacatttg ctcctagaac tctaccacat agccccaaac     4020

agagccatca ccatcacatc cctaacagtc ctgggtcttc ctcagtgtcc agcctgactt     4080

ctgttcttcc tcattccaga tctgcaagat tgtaagacag cctgtgctcc ctcgctcctt     4140

cctctgcatt gcccctcttc tccctctcca aacagaggga actctcctac ccccaaggag     4200

gtgaaagctg ctaccacctc tgtgcccccc cggcaatgcc accaactgga tcctacccga     4260

atttatgatt aagattgctg aagagctgcc aaacactgct gccaccccct ctgttccctt     4320

attgctgctt gtcactgcct gacattcacg gcagaggcaa ggctgctgca gcctcccctg     4380

gctgtgcaca ttccctcctg ctccccagag actgcctccg ccatcccaca gatgatggat     4440

cttcagtggg ttctcttggg ctctaggtcc tgcagaatgt tgtgaggggt ttattttttt     4500

ttaatagtgt tcataaagaa atacatagta ttcttcttct caagacgtgg ggggaaatta     4560

tctcattatc gaggccctgc tatgctgtgt atctgggcgt gttgtatgtc ctgctgccga     4620

tgccttc                                                               4627


<210>  43
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  43

Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser 
                165                 170                 175     


Arg Gly 
        


<210>  44
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu 
1               5                   10                  15      


Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr 
            20                  25                  30          


Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys 
        35                  40                  45              


Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu Gln 
    50                  55                  60                  


Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val 
65                  70                  75                  80  


Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val 
                85                  90                  95      


Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala 
            100                 105                 110         


Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp 
        115                 120                 125             


Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr 
    130                 135                 140                 


Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu 
145                 150                 155                 160 


Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
                165                 170                 175 


<210>  45
<211>  1448
<212>  DNA
<213>  Homo sapiens

<400>  45
aggacctgaa caaggtgttc ccacccgagg tcgctgtgtt tgagccatca gaagcagaga       60

tctcccacac ccaaaaggcc acactggtgt gcctggccac aggcttcttc cccgaccacg      120

tggagctgag ctggtgggtg aatgggaagg aggtgcacag tggggtcagc acagacccgc      180

agcccctcaa ggagcagccc gccctcaatg actccagata ctgcctgagc agccgcctga      240

gggtctcggc caccttctgg cagaaccccc gcaaccactt ccgctgtcaa gtccagttct      300

acgggctctc ggagaatgac gagtggaccc aggatagggc caaacccgtc acccagatcg      360

tcagcgccga ggcctggggt agagcaggtg agtggggcct ggggagatgc ctggaggaga      420

ttaggtgaga ccagctacca gggaaaatgg aaagatccag gtagcagaca agactagatc      480

caaaaagaaa ggaaccagcg cacaccatga aggagaattg ggcacctgtg gttcattctt      540

ctcccagatt ctcagcccaa cagagccaag cagctgggtc ccctttctat gtggcctgtg      600

taactctcat ctgggtggtg ccccccatcc ccctcagtgc tgccacatgc catggattgc      660

aaggacaatg tggctgacat ctgcatggca gaagaaagga ggtgctgggc tgtcagagga      720

agctggtctg ggcctgggag tctgtgccaa ctgcaaatct gactttactt ttaattgcct      780

atgaaaataa ggtctctcat ttattttcct ctccctgctt tctttcagac tgtggcttta      840

cctcgggtaa gtaagccctt ccttttcctc tccctctctc atggttcttg acctagaacc      900

aaggcatgaa gaactcacag acactggagg gtggagggtg ggagagacca gagctacctg      960

tgcacaggta cccacctgtc cttcctccgt gccaacagtg tcctaccagc aaggggtcct     1020

gtctgccacc atcctctatg agatcctgct agggaaggcc accctgtatg ctgtgctggt     1080

cagcgccctt gtgttgatgg ccatggtaag caggagggca ggatggggcc agcaggctgg     1140

aggtgacaca ctgacaccaa gcacccagaa gtatagagtc cctgccagga ttggagctgg     1200

gcagtaggga gggaagagat ttcattcagg tgcctcagaa gataacttgc acctctgtag     1260

gatcacagtg gaagggtcat gctgggaagg agaagctgga gtcaccagaa aacccaatgg     1320

atgttgtgat gagccttact atttgtgtgg tcaatgggcc ctactacttt ctctcaatcc     1380

tcacaactcc tggctcttaa taacccccaa aactttctct tctgcaggtc aagagaaagg     1440

atttctga                                                              1448


<210>  46
<211>  1489
<212>  DNA
<213>  Homo sapiens

<400>  46
aggacctgaa aaacgtgttc ccacccgagg tcgctgtgtt tgagccatca gaagcagaga       60

tctcccacac ccaaaaggcc acactggtat gcctggccac aggcttctac cccgaccacg      120

tggagctgag ctggtgggtg aatgggaagg aggtgcacag tggggtcagc acagacccgc      180

agcccctcaa ggagcagccc gccctcaatg actccagata ctgcctgagc agccgcctga      240

gggtctcggc caccttctgg cagaaccccc gcaaccactt ccgctgtcaa gtccagttct      300

acgggctctc ggagaatgac gagtggaccc aggatagggc caaacccgtc acccagatcg      360

tcagcgccga ggcctggggt agagcaggtg agtggggcct ggggagatgc ctggaggaga      420

ttaggtgaga ccagctacca gggaaaatgg aaagatccag gtagcggaca agactagatc      480

cagaagaaag ccagagtgga caaggtggga tgatcaaggt tcacagggtc agcaaagcac      540

ggtgtgcact tcccccacca agaagcatag aggctgaatg gagcacctca agctcattct      600

tccttcagat cctgacacct tagagctaag ctttcaagtc tccctgagga ccagccatac      660

agctcagcat ctgagtggtg tgcatcccat tctcttctgg ggtcctggtt tcctaagatc      720

atagtgacca cttcgctggc actggagcag catgagggag acagaaccag ggctatcaaa      780

ggaggctgac tttgtactat ctgatatgca tgtgtttgtg gcctgtgagt ctgtgatgta      840

aggctcaatg tccttacaaa gcagcattct ctcatccatt tttcttcccc tgttttcttt      900

cagactgtgg cttcacctcc ggtaagtgag tctctccttt ttctctctat ctttcgccgt      960

ctctgctctc gaaccagggc atggagaatc cacggacaca ggggcgtgag ggaggccaga     1020

gccacctgtg cacaggtgcc tacatgctct gttcttgtca acagagtctt accagcaagg     1080

ggtcctgtct gccaccatcc tctatgagat cttgctaggg aaggccacct tgtatgccgt     1140

gctggtcagt gccctcgtgc tgatggccat ggtaaggagg agggtgggat agggcagatg     1200

atgggggcag gggatggaac atcacacatg ggcataaagg aatctcagag ccagagcaca     1260

gcctaatata tcctatcacc tcaatgaaac cataatgaag ccagactggg gagaaaatgc     1320

agggaatatc acagaatgca tcatgggagg atggagacaa ccagcgagcc ctactcaaat     1380

taggcctcag agcccgcctc ccctgcccta ctcctgctgt gccatagccc ctgaaaccct     1440

gaaaatgttc tctcttccac aggtcaagag aaaggattcc agaggctag                 1489


<210>  47
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  47

Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
            20                  25                  30          


Leu Leu Glu Lys Phe Phe Pro Asp Val Ile Lys Ile His Trp Gln Glu 
        35                  40                  45              


Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys 
    50                  55                  60                  


Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Lys 
65                  70                  75                  80  


Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys 
                85                  90                  95      


Asn Gly Val Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val 
            100                 105                 110         


Ile Thr Met Asp Pro Lys Asp Asn Cys Ser Lys Asp Ala Asn Asp Thr 
        115                 120                 125             


Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Met Tyr Leu Leu 
    130                 135                 140                 


Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu 
145                 150                 155                 160 


Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
                165                 170             


<210>  48
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  48

Asp Lys Gln Leu Asp Ala Asp Val Ser Pro Lys Pro Thr Ile Phe Leu 
1               5                   10                  15      


Pro Ser Ile Ala Glu Thr Lys Leu Gln Lys Ala Gly Thr Tyr Leu Cys 
            20                  25                  30          


Leu Leu Glu Lys Phe Phe Pro Asp Ile Ile Lys Ile His Trp Gln Glu 
        35                  40                  45              


Lys Lys Ser Asn Thr Ile Leu Gly Ser Gln Glu Gly Asn Thr Met Lys 
    50                  55                  60                  


Thr Asn Asp Thr Tyr Met Lys Phe Ser Trp Leu Thr Val Pro Glu Glu 
65                  70                  75                  80  


Ser Leu Asp Lys Glu His Arg Cys Ile Val Arg His Glu Asn Asn Lys 
                85                  90                  95      


Asn Gly Ile Asp Gln Glu Ile Ile Phe Pro Pro Ile Lys Thr Asp Val 
            100                 105                 110         


Thr Thr Val Asp Pro Lys Tyr Asn Tyr Ser Lys Asp Ala Asn Asp Val 
        115                 120                 125             


Ile Thr Met Asp Pro Lys Asp Asn Trp Ser Lys Asp Ala Asn Asp Thr 
    130                 135                 140                 


Leu Leu Leu Gln Leu Thr Asn Thr Ser Ala Tyr Tyr Thr Tyr Leu Leu 
145                 150                 155                 160 


Leu Leu Leu Lys Ser Val Val Tyr Phe Ala Ile Ile Thr Cys Cys Leu 
                165                 170                 175     


Leu Arg Arg Thr Ala Phe Cys Cys Asn Gly Glu Lys Ser 
            180                 185                 


<210>  49
<211>  5591
<212>  DNA
<213>  Homo sapiens

<400>  49
ataaacaact tgatgcagat gtttccccca agcccactat ttttcttcct tcaattgctg       60

aaacaaagct ccagaaggct ggaacatacc tttgtcttct tgagaaattt ttccctgatg      120

ttattaagat acattggcaa gaaaagaaga gcaacacgat tctgggatcc caggagggga      180

acaccatgaa gactaacgac acatacatga aatttagctg gttaacggtg ccagaaaagt      240

cactggacaa agaacacaga tgtatcgtca gacatgagaa taataaaaac ggagttgatc      300

aagaaattat ctttcctcca ataaagacag gtatgtgttt acgcatatca tctgtcagaa      360

cacttctttg aaagtgaatg ctgcattttt tcctttcagt attaatgaaa aacaaacata      420

aatctttctt aaatattgtt acatttaatg gtagcataaa tgccctgcta cttttctata      480

gaattaaaat ggtataggtt ttggagaaaa caaaattgaa aaagttactg aaggtttgtc      540

agcctcagct ccattatcca aaataagaaa gtcacgtgct ggtttttagg gttgttagat      600

ggattaaaga aacaacatac acagaagcat ctagcaacgt gacacgtggt aaacgctcaa      660

aaagtgttct cccttctttt gatgacttta cttgatcagg aaataacata tatatgtctt      720

tcaggaatgt tctgcccaag caggagagtc actcacctca atcttgctac ccacaaagtt      780

taacctaaaa acaacgggtt cattgttgac aaaatgatgt ttatctgttg ttgacagaat      840

gatgtttatc taaaaacagt tccaattttc tatttccttt gctgagacac aaaggggagg      900

caaatgtgca aagcttgagg gtagtcttac cactgtgctt aagtgttctg atttttctag      960

tgatcagggc aaaataaaaa gtatagtaag ttccaaggca gtgaatatta tacaggagag     1020

aagttacagt tttataatgt gttttccttt acactaaatt ctaaaagtaa aaagtctttt     1080

tttttttttg acagagtttc actcttgttg cccaagcagg tgtgctatgg tatgatctca     1140

gctcactgca acctccacct cccgggttca agtgattctc ttacttcagc ctcccgacag     1200

gctgggattg caggcgcctg ccaccacacc tggctaattt ttgtgttttt agtagagatg     1260

gggtttcacc atgttggcca ggctggtctc aaattcctga cctcaagtga tccatccacc     1320

tcggcctcca agtgctggga ttatgggcgt cagccactgt gcccagccta aaagtaaaat     1380

gtctttcatg agcttcccaa ggcagctacg ttaaggagga cacttctctt aatgtcattc     1440

tacagtagat ttctaatgct ctttcttgga agtttgtttt tctgagaaaa gctaaaaata     1500

taacatggaa gtgatcatat tatataatca atgaagtgct tttcaaggag ataaaactaa     1560

tctggtccac acttgcaacc aaccttgatt gagagagaga gagaactcag gatacacttg     1620

aagattttat tatggggaac agttacttta ttctttttac ctcaatcaat gcatggaaat     1680

aagtgatagt cattttcatt tatcttttaa taaatgaagt caccatgagg aaaataaaaa     1740

gacattgaaa acccattaaa gtcagccctt aaagatattt ggacatgcag acttgataac     1800

taacgtttgc attcttgaga cttacccaaa acccatacct caagtccaag tttttagaat     1860

tcatgaaata aagatctcag tgagtgcata aaattgcgca ccagaatcat atccgtatag     1920

acaagaacac atctactaga aaaataataa accaacacac caatgcaact gtgttttctt     1980

ctgttttaaa gtatgttgtc tttgtatgca tgtttgcttc ttcctttttt tttttaacat     2040

cacagataaa ttcaactctc acctcaggtt ttattgagag aactgtcaat gtgacttggc     2100

ctctgtcttt ctagtcccag aaagaattgc actgaaatct gagctcctgt aataaaaaca     2160

accatttgct gagagtaatt aacatactga aagagatttt cttagagtac acaatggtga     2220

cattatattg cctctttata aataactttc tatctatttc tgtggattat tcctacaaag     2280

tacttttcat atgtccaatt tcttttcttc ccctacaact actgtctgaa tactggctct     2340

gctatttgct gatatgattc tcggcaagtt gcctgcactt tttaaacttt atttcctcat     2400

tcagaacatg gggccataca taatacaact cacttcagtg ttattgggga attaaacaaa     2460

aaatgcatgg gaagcattta acatagtgcc tgacacaata atgagtactc agtagatgtt     2520

agcttttatt aatattgttg ttgttatgtc cagaaacact atacctccag aaaatcatgg     2580

gtacttgctg gggacattgg ggatatgcat gatttggaaa agaatgactg ctttttttgc     2640

ttagatgaga aatttttcta agccagactc cttcaaatat gtaagattct gttgtggatt     2700

caaggactga aagaattctt ggccgagtgt ggtggcttat ccctgtaatc ccagcatttt     2760

gtgaggacaa ggcaggaaga ttgcttgagt ccaggagttt gaaaccagcc tgcgcaacat     2820

ggcgaaaccc tgtctctaca aaaaatacaa acattagctc ggagtgagtg ctgacatgtg     2880

cctgtactcc cagctactca gaaggctgag atgggaggat ctcatgagcc tggggagttt     2940

gaggcttcag tgagccgtga tgacaccgta ctatactcca ctccagcctg ggtgacagtg     3000

agaccctgcc tcaaaaaaca aacaaacaaa caaacaaaac aaaattaatc tttttgctga     3060

tgtcatgtca gcagtgtgtg ttgaaggctg taaagcagcc atttgttcag tttatttttc     3120

cattgaacaa gtatttatca aaaacatact ttgtggcagt cactatgcta ggagctatga     3180

atacagaagg aaaagtaaat gctcttggat actacactcc agttgtgata aaaaagaaaa     3240

aatgtattct tcaccaactt caacatcttg atgtgcaaaa acataataca tgaattagat     3300

ctacctaatt acacagaatt agaccaattg tttctggaat tgtgggctca tatttttaat     3360

aactgtcctc ctgcctctct gtcgacaggt tttataaata ttcatttaat tacacacaca     3420

cacacgaaca attgactagt acttgctctc attcttctag atgtcatcac aatggatccc     3480

aaagacaatt gttcaaaaga tgcaaatggt aagcttttgt gtttttccct tcctcctgat     3540

cattttgttt tgaacttctc tggcttgaaa aatcagggaa tggattttgc taggttggat     3600

gctgcagaat ggacctagtg atattttaaa ttagtccctc attttctagg agttgtatta     3660

acaaacctaa ctactgcttt ggggtatgag atgactgtaa attagagagg gtacagtggt     3720

atagtgatat gcttttaatt atttcaaaaa aaagatttta ttcattcatg tgtctttttt     3780

ctttttcttt tctttttttt ttttttttgg acagagtctt gctctgtcac ccaggctgga     3840

gtgcggtggc agtatctcag ctcaccacaa cctccgcctc ccggcttcaa gtgattctcc     3900

tgcctcagct tctcgagtag ctgggactac aggcgcgtgc caccatgccc ggctaatttt     3960

tgtattttta gtagagttgg ggtttcacca tgttggccag gatggcctcg aatttgtgac     4020

ctcgtgatct gccccctcgc cctcccgaac tgttgggatt acaggcgtga gtcactgtgc     4080

ccggcctcct gtcctgtctt ttgtttaatg actgggaaaa acatgatacc atgttgcttc     4140

tcgagttgtt ttgttttagt ctttggtctt tgctagtagc taataacacg aactagtgtt     4200

tatcaagtgc tttttacaca gaagggcttg ggctgtgttc tgcattttct tgtttaaccc     4260

tcttaaaact cctataaaat ggtacatatt tttctcccaa tttacagtcc ctttaaagca     4320

aataattata aaaatcccta tacatgtcac acagctagat ctgggatttc aaatcaggcc     4380

atcaaacaaa gagtttatgt acttagtaag ttttctgttc tttttctaca atagagtcag     4440

atagcaagaa attaccaagc caggaacctg aaacaaaacg gacatcatgt ggggctgggt     4500

gggtgcatgg gctttgcaga ctggactttc actccagctc ttttaatgat taggtgtaag     4560

tgacctacat tttgtgagca acagttttct catcagccaa caaagaataa ttacaccaga     4620

ttcacagtta ttgaagagat aaaggcatga atgtgagatg tctggcatag ggcatctcat     4680

ttagcagaca cagaatgagt acttgtttct ggctttttct ctctacatat gcacaaagaa     4740

tgcgactaga agcatgggct ctagccctgc tcaactttcc tctatttcca ataccaaggg     4800

gctctgactt aggctgccac accaggcaag gagggcagta ccacctcact tgaccaaggg     4860

cagggagtca cggacacatc acttcttgag atccttttcc acaccaagga ctgatgtttc     4920

tggaattctc actttatgaa gacaaaacat ataaatggaa attttctcag gtagagactc     4980

actcttgtag ctcattgagt aggcactagt ggtccacccc cactgtcttt acttattcct     5040

tgacatcaca tatctcttgc aaaacctcaa ataatattaa atgcaatcac ccaataatag     5100

catagccata attagaggca tttaggaaag acaggtgagt gtgccacaac tacctaacac     5160

atcagcaaat ctggattaac cactttcttt gattttccac aatgcaacct tactttttaa     5220

tagttgggaa tgttctaagt gaatttagca gaggttgtta atcaacttga aagctgaatt     5280

ctgacttgtc tgactcttgg tggtgctggt agcagtagat gtttactttt aggttttggt     5340

ggtggtggaa tatcacttca acgtaaatca tcagaaataa gtatttgtga acccctctcg     5400

cattaatgta tcttattctg taaaaagaac atgtgcaatt tctcttagat acactactgc     5460

tgcagctcac aaacacctct gcatattaca tgtacctcct cctgctcctc aagagtgtgg     5520

tctattttgc catcatcacc tgctgtctgc ttagaagaac ggctttctgc tgcaatggag     5580

agaaatcata a                                                          5591


<210>  50
<211>  9549
<212>  DNA
<213>  Homo sapiens

<400>  50
ataaacaact tgatgcagat gtttccccca agcccactat ttttcttcct tcgattgctg       60

aaacaaaact ccagaaggct ggaacatacc tttgtcttct tgagaaattt ttcccagata      120

ttattaagat acattggcaa gaaaagaaga gcaacacgat tctgggatcc caggagggga      180

acaccatgaa gactaacgac acatacatga aatttagctg gttaacggtg ccagaagagt      240

cactggacaa agaacacaga tgtatcgtca gacatgagaa taataaaaac ggaattgatc      300

aagaaattat ctttcctcca ataaagacag gtatgtgttt acacatatca tctgtcagaa      360

cacttctttg aaagtgaatg ctgcattttt tcctttcagt attaatgaaa aacataaatc      420

tttcttaaaa attgttacat ttaatggtag cgtaaatgcc ctgctacttt tctatagaat      480

taaaatggta taggttttgg agaaaacaaa attgaaaaag ttgctgaagg tttgtcagcc      540

tcagctccat tatccaaaat aagaaagtca cgtgctggtt tttagggttg ttagatggat      600

taaagaaaca acatacacag aagcatctag caacgtgaca cgtggtaaac gctcaaaaag      660

tgttctccct tcttttgatg actttacttg atcaggaaat aacatatata tgtctttcag      720

gaatgttctg cccaagcagg agagtcactc acctcaatct tgctacccac aaagtttaac      780

ctaaaaacaa cgggttcatt gttgacaaaa taatgtttat ctgaagataa ctgtagatca      840

tatttatctg tagataatgt ttatctgtgg agtgtggctc tacaaaacat agaatagtct      900

tggtcactgc agttttatag aggccttggg tttttcagag tttcatttta tatatcacca      960

taaagtaaca tttcataatt acaggttggt aaggcttaca tgtacaaaca ttcttccatt     1020

ttccataata aatgcatttc ctgccattgg tgaatgcagc tcaataaaca tttattgtac     1080

aattatgaca cgccaggctt agtggaaatg tggatgaaca gacaaggatg agttactgtc     1140

ctaaggatga tgcatgacag tgcagagaat atactctctt cctgatcact cagggtcact     1200

catgattcat gcgcgaggtc ccaaaacagt gcctttgatg cagattctgt acatctctag     1260

acgattggtc caagggctga atgtgctctg gcccagtggt ccagtctgtc actatatgtc     1320

aacatcctga atatgaacat aacagtccaa catctcaaga gtgggcatga aaaggactca     1380

ttttgtgctt tttcctgtgg ttaacaagtc ctttttagcc tgggggaaca agcattaaca     1440

aaatgtttga agatctttgc cacgtaccat tccaaatttc tagggtaagt ctttagcttt     1500

tcagatcctg agtttctgca atgatcaaat gtgatttgga cagttgcgtt gactttctcc     1560

tggggctata atggagtgca aaggaaacaa tggcagggaa aatgcttgct ttcaaaatgg     1620

tagcatggat gtgttcattc gtgtagttac tgtattaggt atagcctttc ctgaaactaa     1680

ctgaagtggg gttataaaaa cagtcccaat tttctatttc ctttgctgag acacaaagag     1740

gagacaaaag agcaaagctt gagggtagtt ttaccactgt gcttaagtgt tctgattttt     1800

ccagtgatca gggtgaaata aaaagcatag taagttccag ggcagtgaat accatacagg     1860

agacaagtta cagttttata atgtgtttta ctttacacta aattctaaaa gtaaaatgtc     1920

tttttttttt tccgagacag agtttcactc ttgtagccca ggcaggagtg ctatggtgtg     1980

atctcggctc acagcaacct ccacctccca gtttcaagcg attcttctgc ctcagcctcc     2040

cgagaagttg aaattacagg tgcctggcac catatctcgc taattattct atttttagta     2100

gagatcgggt tttaccatgt tggccaggct ggtctcgaac tcctgacttc aagtgatcca     2160

cccgcctcag cctcccaaag tgctgggatt acaggtgtga gtcactgtgc cggacctaac     2220

agtaaaatgt ctttcatgtg cttctcaagg caactacatt aaggaggaca catctcttaa     2280

tgtcattcta cagtagattt ctaatgctct ttcttggaag tttgtttttc tgagaagagc     2340

taaaaatata ataacatgga agtgatcata ttatataatc aatgaagtgc tttcaaagga     2400

gataaaacta acctggtctg catttgcaac cagccttgat tgagagagag agaactcagg     2460

atacacttag agattttatt atggggaata gttactttat tcattttacc tcaatcaatg     2520

catggaaata agtgacagtc attttcattt atcttttaat aaataaagtc accatgagga     2580

aaatgaaaac ccattaaagt cagtccttaa agatatttgg acatgcagac atgataacta     2640

acatttccat tcgtgagact tacccaaaac ctatacctca agtccatttc ttagaataca     2700

tgaaataaag atctcagtga gtgtataaaa ctgcacacca gaatcatatc cgtatagaca     2760

agaatacatc tactagaaaa atataaacca aaacaccaag gtgactctgt ttttttctgt     2820

tttaaaatat gttgtctttg tatgcatgtt tgcttcttcc tttttttttt taaacatcgc     2880

agataaattc aactctcacc tcagttgaga gagaactgtc aatgtgactt ggcctctctc     2940

tttctagtcc cagaaagaat tgcactgaaa tgctgagctc ctgtaataaa aatgaccatt     3000

tgctgagagt aattaacata ctgaaagaga ttttcttaga atagtgcaca atggcccaat     3060

ggtgacatta tattgtctct ttataaatta ttttctatct atttctgtgg attatttcta     3120

caaagcactt ttcatatgtc caattccttt tattccccta caagtactga ctgactactg     3180

gctctgctgt tcactgatat gactttcggc aagttgcctg cactttttaa acgttatttc     3240

ctcattcaga acatggggcc atacaaaata caactcactt cagtgttatt ggggaattaa     3300

acaaataaat gcatgggaag catttaacat agtgcctgac acaataatga gcactcagta     3360

gatgttagct tttattaata ttgttgttgc tatgtccaga aacactatac ctccagaaaa     3420

tcatgggtac ttgctgggga cgttggggat atgcatgatt ttgaaaggag tgactgctct     3480

ttactgctca gatgagaaat ttttctaagc cagactcctt caaacatgta agattctgtt     3540

gtggattcta ggactgaaag aattcttggc cgagtgtggt ggcttatcct ggtaatctca     3600

tcatttggga ggacaaggca ggaagattgc ttgagcccag gagttggaaa caagcctgga     3660

caacatggcg aaaccctgtc tctacaaaaa atacaaacat tagctggtca tgggagtgag     3720

tgcctgtact cccagctact caggaggcta agataggagg atcacctgag cctgggcagt     3780

ttgaggtttc agtgagccgt gatgacacca tactatactc cactccagcc tgggtgacag     3840

tgacatcctg cctcaaaaaa acccccaaaa ttattctttt tgctgatttc atgtcagcag     3900

tgtgtgctga aggctgtaaa gtagccactt gttctgttta tttttccatt gaacaagtat     3960

ttatcaaaaa cgtactttgt ggaaggcact gtgctaggaa ctatgcatac agaaggaaaa     4020

ccaaatgttc ttggatacta cactccagtt gtgataaaaa agaaaaaagt attcttcaca     4080

aacttcaaca ttttgatgtg caaaaacata atatatgaat tagatctacc taactacaca     4140

gaattagacc aattatttct gggattatgg gctcatattt ttaataactg tcctcctacc     4200

tctctgttga caggttttat aaatattcat ttaattacac acagtcacag acacactcag     4260

acacacacac atacacacac acacacacct tgacaaataa tgggcatgaa caattgactg     4320

gtacttgctc tcattcttct agatgtcacc acagtggatc ccaaatacaa ttattcaaag     4380

gatgcaaatg gtaagttttt gtgtttttta tttcctcctg atcattttaa gttttgaact     4440

tctctggctt gaaaaatcag ggaatggatt ttgctaggtt ggatgctgca gaatggacct     4500

aatcatattt taaattagtc cctctttttc taggagttgt attaacaaac ctaactactg     4560

cttcatgtaa gagatgactg taaattgaag ggtacagtga tatgctttca gttatttcaa     4620

aaaacagact ttactcatcc atgtgtcttt tttcttttct tttttttctt ttttgagacg     4680

gagtctcgct ctgttgaaca ggctggattg cagtgacgcg atctcacctc actacaacct     4740

ccgcctctgg agttcaagcg attctccagc ctcagcttct caagtagctg ggactacagg     4800

cacatgccac catgtccggg tcatctttgt atttttagca gagaccgggt ttcactatgt     4860

tggccaggct ggtctagaat tcctgacttc gtgatctgcc ccctcagccc tccgaagtgc     4920

tgggattaca gacgtgagtc actgtgcccg gcctaacagt aaaatgtctt tcatgcgctt     4980

ctcaaggcaa ctacgttaag gaggacactt ctcttaatgt cattctacag tagatttcta     5040

atgctctttc ttggaagttt gtttttctga gaaaagctaa aaatataaca tggaagtgat     5100

catattgtat aatcaatgaa gtgcttttca aggagataaa actaatctgg tccacgtttg     5160

caaccaacct tgattgagag agagagagaa ctcaggatac acttggagat tttattatgg     5220

ggaatagtta ctttattctt ttttcctcaa tcaattcatg gaaataagtg atagtcatat     5280

tcatttatct tttaataaat gaagtcacca tgaggaaaat aaaaagacat tgaaaaccca     5340

ttaaagttag cccttaaaga tatttggaca tgcagacttg ataactaacg tttgcattct     5400

tgagacttac ccaaaaccca tacctcaagt ccatgttttt agaattcatg aaataaagat     5460

ctcagtgagt gcataaaatt gcgcaccaga atcatatccg tatagacaag aacacatcta     5520

ctagaaaaat aataaaccaa cacaccaatg caactgtgtt ttcttctgtt ttaaaatatg     5580

ttgtctttgt atgcatgttt gcttcttcct tttttttttt taacatcaca gataaattca     5640

actctcacct caggttttat tgagagaact gtcaatgtga cttggcctct gtctttctag     5700

tcccagaaag aatcgcactg aaatgctgag ctcctgtaat aaaaatgacc atttgctgag     5760

agtaattaac atactgaaag agattttctt agagtacaca atggtgacat tatattgtct     5820

ctttataaat aactttctat ctatttctgt ggattattcc tacaaagtac ttttcatatg     5880

tccagtttct tttcttcccc tacaactacc gtctgaatac tggctctgct atttgctgat     5940

atgattctcg gcaagttgcc tgcacttttt aaactttatt tcctcattca gaacatgggg     6000

ccatgtaata ctcatgtacg tgagtattac gtaataatgc tcacttaagt gttactgggg     6060

aattaaacaa aaaaatgcat ggcaagcatt taacatagtg cctgacacaa taatgagcac     6120

tcagtagatg ttagatttta ttaatattgt tgttgttatg tccggaaaca ctatacctcc     6180

agaaaatcat gggtacttgc ttgggatgtt ggggatatgc atgatttgga aaggtatgac     6240

tgcttttttc tgcttagatg agaaattttt ctaagccaga ctccttcaaa tatgtaagat     6300

tctgttgtgg attctaggac ggaaagaatt cttggtcagg tgtggtttct tatccctgta     6360

atcccagaat tttgggagga caaggcagga agattgcttg agcccaggag tttgaaacca     6420

gcctgggcaa caagacgaaa ccctgtctct acaaaagtac ataaattagc ttggcttggt     6480

ggtgtgtgcc tgtattacca gctattcggg agactgagat gggaggatct cctgaacctg     6540

tgaagtttga ggcttcagtg agccgtgatg acaccatact atactcgact ccagcctgtg     6600

cgacagtgag actctgcgtc aaaaaaaaaa ccccaaaatt attgtttttg ctgatttcag     6660

gtcagcagtg tgtgctgaag ggtgtaaagt agccacttga tcagtttatt tttccactga     6720

acaagtattt atcaaaaaca tactttgtgg tctgtttttg ataaataaaa aggcactgtg     6780

ctaggagcca tgaatacaga aggaaaacca aatgttcttg gatactacac tccagttgtg     6840

ataaaaaaga aaaatgtatt cttcacgaac ttcaacattt tgatatgcaa aaacatagta     6900

tataaattag atctacctga ttacgtagaa tcagaccaat tatttctgga attgagggct     6960

catattttta ataactgtcc tcctgcctct ctgttgacag gttttataaa tattcattta     7020

attacacaca cacacacaca caccttgaca aataatggac atgaacaatt gactagtact     7080

tgctctcatt cttctagatg tcatcacaat ggatcccaaa gacaattggt caaaagatgc     7140

aaatggtaag cttttgtgtt tttcctttcc tcctgatcat tttaagtttt gaacttctct     7200

ggcttgaaaa atcagggaat gggccgggtg cggtggctca cgcctgtaat cccagcactt     7260

tgggaggccg aggcgggcgg atcacgaggt caggagatcg agaccatccc ggctaaaacg     7320

gtgaaacccc gtctctacta aaaatacaaa aaattagccg ggcttagtgg cgggcgcctg     7380

tagtcccagc tacttgggag gctgaggcag gagaatggcg tgaacccggg aggcggagct     7440

tgcagtgagc cgagattgcg ccactgcact ccactccagc ctgggcgaca gagcgagact     7500

ccgtctcaaa aaaaaaaaaa aaaaaaaaaa aagaaaaatc agggaatgga ttttgctagg     7560

ttggatgctg cagaatggac ctagtgatat tttaaattag tccctctttt tctaggagtt     7620

gtattaacaa acctaactac tgcttcgggt atgagatgac tgtaaattag agggtacagt     7680

gatatgcttt cagttatttc aaaaaacaga ctttattcat ccgtctgtct tttttttttt     7740

tttttttttt tttttttgag acggaggagt ctcactctat cacccaggct ggagtgcagt     7800

ggcgcgatct cggctcacca taacctccgc cttactggtt caagcgattc tccagcctca     7860

gcttctcaag tagctgggac tacaggtgca caccaccata cctggctaat ttttgtattt     7920

ttaatagaga tggggtttca ccacgctggc caggatggtc ttgaattctt gacctcgtga     7980

tctgccccct cgggctccca aacttctggg attataggcg tgagccactg tgcccggcct     8040

tctgtctttt gttataatga ctggggaaaa catgatacca tgttgcttct tgagttgttt     8100

tgttttagtc tttggtcttt gctagtagct aataacacga actagtgttt atcaagtgct     8160

ttttacacag aagggcttgt tctgcatttt ctagtttaat catcttaata ctcctataaa     8220

gtagtacaat atattttctc ccattttaca gtccctttaa agtaaataac tataaaaatc     8280

ccttatacat gtcacacagc taggtctggc atttcaaatc aggacatcaa acaaagaatt     8340

cgtgcagtta ctaagtcctc tattttttct acaatagaaa aaatagcaag aattacagat     8400

agcaagacat tacaaggcag gaatctgaaa cgaaagggac ataatgtggg gctgggtggg     8460

tgcatgagct ttgcagacta gactttcatt ccagctcttt taatgattag gtgtaagtga     8520

cctacatttt gtgagtaaca gttttctcat cagccaacta agaataatta caccagattc     8580

acagttattg aagagataag ggcatgaatg tgagatgtct ggcgtagggt atctcattta     8640

gcagacacag aatgaatact tgtttctggc tttttctctc tacatatgca caaagaatgt     8700

gactagaagc attggctcta gccctgctca actttcctct atttccaata ccaaggggct     8760

ctgacttagg ctgccacacc aggcaaggag gggcagtacc acctcacttg accaagggca     8820

gggagtcacg gacacatcac ttcctgagat ccttttccac accaaggact gatgtttctg     8880

gaattctcac tttatgaaga caaaacatat aaatggaaat ttctgcagga agagactcac     8940

tcttgtagct cattgagtag gcactagtgg tccaccccca ctgtctttac ttattccttg     9000

acatcacata tctcttgtaa aacctcaaat aatgttaaat gcaatcaccc aataatagca     9060

tagccataat tagaggcatt taggaaagac aggtgagtgt gccacaacta cctaacacat     9120

cagcaaatct ggattaacca ctttctttga ttttccacaa tgcaacctta ctttttaata     9180

gttgggaatg ttctaagtga atttagcaga ggttgttaat caacttgaaa gctgaattct     9240

gacttgtctg actcttggtg gtgctggtag cagtagatgt ttacttttag gttttggtgg     9300

tggtggaata tcacttcaac gtaaatcatc agaaataagt atttgtgaac ccctctcgca     9360

ttaatatatc ttattctgta aaaagaacat gtgcaatttc tcttagatac actactgctg     9420

cagctcacaa acacctctgc atattacacg tacctcctcc tgctcctcaa gagtgtggtc     9480

tattttgcca tcatcacctg ctgtctgctt agaagaacgg ctttctgctg caatggagag     9540

aaatcataa                                                             9549


<210>  51
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  51

Ser Gln Pro His Thr Lys Pro Ser Val Phe Val Met Lys Asn Gly Thr 
1               5                   10                  15      


Asn Val Ala Cys Leu Val Lys Glu Phe Tyr Pro Lys Asp Ile Arg Ile 
            20                  25                  30          


Asn Leu Val Ser Ser Lys Lys Ile Thr Glu Phe Asp Pro Ala Ile Val 
        35                  40                  45              


Ile Ser Pro Ser Gly Lys Tyr Asn Ala Val Lys Leu Gly Lys Tyr Glu 
    50                  55                  60                  


Asp Ser Asn Ser Val Thr Cys Ser Val Gln His Asp Asn Lys Thr Val 
65                  70                  75                  80  


His Ser Thr Asp Phe Glu Val Lys Thr Asp Ser Thr Asp His Val Lys 
                85                  90                  95      


Pro Lys Glu Thr Glu Asn Thr Lys Gln Pro Ser Lys Ser Cys His Lys 
            100                 105                 110         


Pro Lys Ala Ile Val His Thr Glu Lys Val Asn Met Met Ser Leu Thr 
        115                 120                 125             


Val Leu Gly Leu Arg Met Leu Phe Ala Lys Thr Val Ala Val Asn Phe 
    130                 135                 140                 


Leu Leu Thr Ala Lys Leu Phe Phe Leu 
145                 150             


<210>  52
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Glu Gln Gly Lys Gly Leu Ala Val Leu Ile Leu Ala Ile Ile Leu 
1               5                   10                  15      


Leu Gln Gly Thr Leu Ala Gln Ser Ile Lys Gly Asn His Leu Val Lys 
            20                  25                  30          


Val Tyr Asp Tyr Gln Glu Asp Gly Ser Val Leu Leu Thr Cys Asp Ala 
        35                  40                  45              


Glu Ala Lys Asn Ile Thr Trp Phe Lys Asp Gly Lys Met Ile Gly Phe 
    50                  55                  60                  


Leu Thr Glu Asp Lys Lys Lys Trp Asn Leu Gly Ser Asn Ala Lys Asp 
65                  70                  75                  80  


Pro Arg Gly Met Tyr Gln Cys Lys Gly Ser Gln Asn Lys Ser Lys Pro 
                85                  90                  95      


Leu Gln Val Tyr Tyr Arg Met Cys Gln Asn Cys Ile Glu Leu Asn Ala 
            100                 105                 110         


Ala Thr Ile Ser Gly Phe Leu Phe Ala Glu Ile Val Ser Ile Phe Val 
        115                 120                 125             


Leu Ala Val Gly Val Tyr Phe Ile Ala Gly Gln Asp Gly Val Arg Gln 
    130                 135                 140                 


Ser Arg Ala Ser Asp Lys Gln Thr Leu Leu Pro Asn Asp Gln Leu Tyr 
145                 150                 155                 160 


Gln Pro Leu Lys Asp Arg Glu Asp Asp Gln Tyr Ser His Leu Gln Gly 
                165                 170                 175     


Asn Gln Leu Arg Arg Asn 
            180         


<210>  53
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Met Cys Gln Ser Cys 
                85                  90                  95      


Val Glu Leu Asp Pro Ala Thr Val Ala Gly Ile Ile Val Thr Asp Val 
            100                 105                 110         


Ile Ala Thr Leu Leu Leu Ala Leu Gly Val Phe Cys Phe Ala Gly His 
        115                 120                 125             


Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu Leu Arg 
    130                 135                 140                 


Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala Gln Tyr 
145                 150                 155                 160 


Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
                165                 170     


<210>  54
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Glu His Ser Thr Phe Leu Ser Gly Leu Val Leu Ala Thr Leu Leu 
1               5                   10                  15      


Ser Gln Val Ser Pro Phe Lys Ile Pro Ile Glu Glu Leu Glu Asp Arg 
            20                  25                  30          


Val Phe Val Asn Cys Asn Thr Ser Ile Thr Trp Val Glu Gly Thr Val 
        35                  40                  45              


Gly Thr Leu Leu Ser Asp Ile Thr Arg Leu Asp Leu Gly Lys Arg Ile 
    50                  55                  60                  


Leu Asp Pro Arg Gly Ile Tyr Arg Cys Asn Gly Thr Asp Ile Tyr Lys 
65                  70                  75                  80  


Asp Lys Glu Ser Thr Val Gln Val His Tyr Arg Thr Ala Asp Thr Gln 
                85                  90                  95      


Ala Leu Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp 
            100                 105                 110         


Asp Ala Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys 
        115                 120                 125         


<210>  55
<211>  207
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Gln Ser Gly Thr His Trp Arg Val Leu Gly Leu Cys Leu Leu Ser 
1               5                   10                  15      


Val Gly Val Trp Gly Gln Asp Gly Asn Glu Glu Met Gly Gly Ile Thr 
            20                  25                  30          


Gln Thr Pro Tyr Lys Val Ser Ile Ser Gly Thr Thr Val Ile Leu Thr 
        35                  40                  45              


Cys Pro Gln Tyr Pro Gly Ser Glu Ile Leu Trp Gln His Asn Asp Lys 
    50                  55                  60                  


Asn Ile Gly Gly Asp Glu Asp Asp Lys Asn Ile Gly Ser Asp Glu Asp 
65                  70                  75                  80  


His Leu Ser Leu Lys Glu Phe Ser Glu Leu Glu Gln Ser Gly Tyr Tyr 
                85                  90                  95      


Val Cys Tyr Pro Arg Gly Ser Lys Pro Glu Asp Ala Asn Phe Tyr Leu 
            100                 105                 110         


Tyr Leu Arg Ala Arg Val Cys Glu Asn Cys Met Glu Met Asp Val Met 
        115                 120                 125             


Ser Val Ala Thr Ile Val Ile Val Asp Ile Cys Ile Thr Gly Gly Leu 
    130                 135                 140                 


Leu Leu Leu Val Tyr Tyr Trp Ser Lys Asn Arg Lys Ala Lys Ala Lys 
145                 150                 155                 160 


Pro Val Thr Arg Gly Ala Gly Ala Gly Gly Arg Gln Arg Gly Gln Asn 
                165                 170                 175     


Lys Glu Arg Pro Pro Pro Val Pro Asn Pro Asp Tyr Glu Pro Ile Arg 
            180                 185                 190         


Lys Gly Gln Arg Asp Leu Tyr Ser Gly Leu Asn Gln Arg Arg Ile 
        195                 200                 205         


<210>  56
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Ala Pro Arg Cys Arg 
            260                 265                 270         


Glu Arg Arg Arg Asn Glu Arg Leu Arg Arg Glu Ser Val Arg Pro Val 
        275                 280                 285             


<210>  57
<211>  309
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Lys Arg Gly Arg Lys 
            260                 265                 270         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        275                 280                 285             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    290                 295                 300                 


Gly Gly Cys Glu Leu 
305                 


<210>  58
<211>  349
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Met Gly His Thr Arg Arg Gln Gly Thr Ser Pro Ser Lys Cys Pro Tyr 
1               5                   10                  15      


Leu Asn Phe Phe Gln Leu Leu Val Leu Ala Gly Leu Ser His Phe Cys 
            20                  25                  30          


Ser Gly Val Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu 
        35                  40                  45              


Ser Cys Gly His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile 
    50                  55                  60                  


Tyr Trp Gln Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp 
65                  70                  75                  80  


Met Asn Ile Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr 
                85                  90                  95      


Asn Asn Leu Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly 
            100                 105                 110         


Thr Tyr Glu Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg 
        115                 120                 125             


Glu His Leu Ala Glu Val Thr Leu Ser Val Lys Ala Asp Phe Pro Thr 
    130                 135                 140                 


Pro Ser Ile Ser Asp Phe Glu Ile Pro Thr Ser Asn Ile Arg Arg Ile 
145                 150                 155                 160 


Ile Cys Ser Thr Ser Gly Gly Phe Pro Glu Pro His Leu Ser Trp Leu 
                165                 170                 175     


Glu Asn Gly Glu Glu Leu Asn Ala Ile Asn Thr Thr Val Ser Gln Asp 
            180                 185                 190         


Pro Glu Thr Glu Leu Tyr Ala Val Ser Ser Lys Leu Asp Phe Asn Met 
        195                 200                 205             


Thr Thr Asn His Ser Phe Met Cys Leu Ile Lys Tyr Gly His Leu Arg 
    210                 215                 220                 


Val Asn Gln Thr Phe Asn Trp Asn Thr Thr Lys Gln Glu His Phe Pro 
225                 230                 235                 240 


Asp Asn Leu Leu Pro Ser Trp Ala Ile Thr Leu Ile Ser Val Asn Gly 
                245                 250                 255     


Ile Phe Val Ile Cys Cys Leu Thr Tyr Cys Phe Arg Ser Lys Arg Ser 
            260                 265                 270         


Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly 
        275                 280                 285             


Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala 
    290                 295                 300                 


Ala Tyr Arg Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
305                 310                 315                 320 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
                325                 330                 335     


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
            340                 345                 


<210>  59
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  60
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210>  61
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  62

Gly Gly Gly Gly Ser 
1               5   


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  63

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  64

Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala 
1               5                   10  


<210>  65
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  65
attcccaata tccagaaccc tgaccctgcc                                        30


<210>  66
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  66

Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu 
1               5                   10      


<210>  67
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  67
ctggaggatc tgaaaaacgt gttccctcct gaa                                    33


<210>  68
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  68
gggcuuggug aucugccucg                                                   20


<210>  69
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  69
atccagaacc ctgaccctgc cgtgtaccag ctgagagact ctaaatccag tgacaagtct       60

gtctgcctat tcaccgattt tgattctcaa acaaatgtgt cacaaagtaa ggattctgat      120

gtgtatatca cagacaaaac tgtgctagac atgaggtcta tggacttcaa gagcaacagt      180

gctgtggcct ggagcaacaa atctgacttt gcatgtgcaa acgccttcaa caacagcatt      240

attccagaag acaccttctt ccccagccca gaaagttcct gtgatgtcaa gctggtcgag      300

aaaagctttg aaacagatac gaacctaaac tttcaaaacc tgtcagtgat tgggttccga      360

atcctcctcc tgaaagtggc cgggtttaat ctgctcatga cgctgcggct gtggtccagc      420


<210>  70
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  70
gatctgaaaa acgtgttccc tcctgaagtg gctgtctttg aaccatccga ggccgagatt       60

tcccataccc agaaagcaac tctggtctgt ctggccactg gattctaccc cgatcacgtg      120

gaactgtctt ggtgggtgaa cggcaaggaa gtccattccg gagtctctac cgaccctcag      180

cccctcaagg agcagcctgc tctcaacgat tctcggtact gcctgtcatc tcgactgaga      240

gtgtctgcca ccttctggca gaaccctaga aaccactttc ggtgtcaggt ccagttttac      300

ggcctgagcg agaacgatga gtggacacag gatagagcca aacctgtgac acagattgtg      360

agcgccgagg cttggggacg agccgattgt ggcttcacat ccgagtctta ccagcaggga      420

gtgctgtctg ctacaatcct ctacgaaatt ctcctgggga aggccaccct gtacgctgtc      480

ctcgtgtctg ctctggtgct catggctatg gtcaaacgaa aggactctag aggc            534


<210>  71
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  71
gacctgaaca aggtgttccc acccgaggtc gctgtgtttg agccatcaga agcagagatc       60

tcccacaccc aaaaggccac actggtgtgc ctggccacag gcttcttccc cgaccacgtg      120

gagctgagct ggtgggtgaa tgggaaggag gtgcacagtg gggtcagcac agacccgcag      180

cccctcaagg agcagcccgc cctcaatgac tccagatact gcctgagcag ccgcctgagg      240

gtctcggcca ccttctggca gaacccccgc aaccacttcc gctgtcaagt ccagttctac      300

gggctctcgg agaatgacga gtggacccag gatagggcca aacccgtcac ccagatcgtc      360

agcgccgagg cctggggtag agcagactgt ggctttacct cggtgtccta ccagcaaggg      420

gtcctgtctg ccaccatcct ctatgagatc ctgctaggga aggccaccct gtatgctgtg      480

ctggtcagcg cccttgtgtt gatggccatg gtcaagagaa aggatttc                   528


<210>  72
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  72

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val 
        115                 120                 125             


Ala Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala 
    130                 135                 140                 


Thr Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu 
145                 150                 155                 160 


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
                165                 170                 175     


Pro Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys 
            180                 185                 190         


Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg 
        195                 200                 205             


Asn His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp 
    210                 215                 220                 


Glu Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala 
225                 230                 235                 240 


Glu Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln 
                245                 250                 255     


Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys 
            260                 265                 270         


Ala Thr Leu Tyr Ala Val Leu Val Ser Ala Leu Val Leu Met Ala Met 
        275                 280                 285             


Val Lys Arg Lys Asp Ser Arg Gly 
    290                 295     


<210>  73
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  73
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cctctggatt taccttcagt agctatatta tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagaaa caaatactac      180

gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagagatacg      300

gatggctacg attttgacta ctggggccag ggaaccctgg tcaccgtcct ggaggatctg      360

aaaaacgtgt tccctcctga agtggctgtc tttgaaccat ccgaggccga gatttcccat      420

acccagaaag caactctggt ctgtctggcc actggattct accccgatca cgtggaactg      480

tcttggtggg tgaacggcaa ggaagtccat tccggagtct ctaccgaccc tcagcccctc      540

aaggagcagc ctgctctcaa cgattctcgg tactgcctgt catctcgact gagagtgtct      600

gccaccttct ggcagaaccc tagaaaccac tttcggtgtc aggtccagtt ttacggcctg      660

agcgagaacg atgagtggac acaggataga gccaaacctg tgacacagat tgtgagcgcc      720

gaggcttggg gacgagccga ttgtggcttc acatccgagt cttaccagca gggagtgctg      780

tctgctacaa tcctctacga aattctcctg gggaaggcca ccctgtacgc tgtcctcgtg      840

tctgctctgg tgctcatggc tatggtcaaa cgaaaggact ctagaggc                   888


<210>  74
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  74

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Ile Pro Asn Ile Gln Asn 
            100                 105                 110         


Pro Asp Pro Ala Val Tyr Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys 
        115                 120                 125             


Ser Val Cys Leu Phe Thr Asp Phe Asp Ser Gln Thr Asn Val Ser Gln 
    130                 135                 140                 


Ser Lys Asp Ser Asp Val Tyr Ile Thr Asp Lys Thr Val Leu Asp Met 
145                 150                 155                 160 


Arg Ser Met Asp Phe Lys Ser Asn Ser Ala Val Ala Trp Ser Asn Lys 
                165                 170                 175     


Ser Asp Phe Ala Cys Ala Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu 
            180                 185                 190         


Asp Thr Phe Phe Pro Ser Pro Glu Ser Ser Cys Asp Val Lys Leu Val 
        195                 200                 205             


Glu Lys Ser Phe Glu Thr Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser 
    210                 215                 220                 


Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
225                 230                 235                 240 


Leu Met Thr Leu Arg Leu Trp Ser Ser 
                245                 


<210>  75
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  75
gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc       60

ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct      120

ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc      180

aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct      240

gaagattttg cagtttatta ctgtcagcag cgtaccaact ggccgctcac tttcggcgga      300

gggaccaagg tggagatcat tcccaatatc cagaaccctg accctgccgt gtaccagctg      360

agagactcta aatccagtga caagtctgtc tgcctattca ccgattttga ttctcaaaca      420

aatgtgtcac aaagtaagga ttctgatgtg tatatcacag acaaaactgt gctagacatg      480

aggtctatgg acttcaagag caacagtgct gtggcctgga gcaacaaatc tgactttgca      540

tgtgcaaacg ccttcaacaa cagcattatt ccagaagaca ccttcttccc cagcccagaa      600

agttcctgtg atgtcaagct ggtcgagaaa agctttgaaa cagatacgaa cctaaacttt      660

caaaacctgt cagtgattgg gttccgaatc ctcctcctga aagtggccgg gtttaatctg      720

ctcatgacgc tgcggctgtg gtccagc                                          747


<210>  76
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro 
1               5                   10                  15      


Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val 
            20                  25                  30          


Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe 
        35                  40                  45              


Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser 
    50                  55                  60                  


Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp 
65                  70                  75                  80  


Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val 
                85                  90                  95      


Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp 
            100                 105                 110         


Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu 
        115                 120                 125             


Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe 
    130                 135                 140                 


Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser 
145                 150                 155                 160 


Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala 
                165                 170                 175     


Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala 
            180                 185                 190         


Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala 
        195                 200                 205             


Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His 
    210                 215                 220                 


Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val 
225                 230                 235                 240 


Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu 
                245                 250                 


<210>  77
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  77
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc       60

gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg      120

ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc      180

tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat      240

cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt      300

ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg      360

acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc      420

tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc      480

gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct      540

ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag      600

ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc      660

agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg      720

acccccgaaa tcccagccgg actcccttca ccgaggtcgg aa                         762


<210>  78
<211>  864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  78
atgggccaca cacggaggca gggaacatca ccatccaagt gtccatacct caatttcttt       60

cagctcttgg tgctggctgg tctttctcac ttctgttcag gtgttatcca cgtgaccaag      120

gaagtgaaag aagtggcaac gctgtcctgt ggtcacaatg tttctgttga agagctggca      180

caaactcgca tctactggca aaaggagaag aaaatggtgc tgactatgat gtctggggac      240

atgaatatat ggcccgagta caagaaccgg accatctttg atatcactaa taacctctcc      300

attgtgatcc tggctctgcg cccatctgac gagggcacat acgagtgtgt tgttctgaag      360

tatgaaaaag acgctttcaa gcgggaacac ctggctgaag tgacgttatc agtcaaagct      420

gacttcccta cacctagtat atctgacttt gaaattccaa cttctaatat tagaaggata      480

atttgctcaa cctctggagg ttttccagag cctcacctct cctggttgga aaatggagaa      540

gaattaaatg ccatcaacac aacagtttcc caagatcctg aaactgagct ctatgctgtt      600

agcagcaaac tggatttcaa tatgacaacc aaccacagct tcatgtgtct catcaagtat      660

ggacatttaa gagtgaatca gaccttcaac tggaatacaa ccaagcaaga gcattttcct      720

gataacctgc tcccatcctg ggccattacc ttaatctcag taaatggaat ttttgtgata      780

tgctgcctga cctactgctt tgccccaaga tgcagagaga gaaggaggaa tgagagattg      840

agaagggaaa gtgtacgccc tgta                                             864


<210>  79
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  79

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ile Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Asp Gly Tyr Asp Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val 
        115     


<210>  80
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  80

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Thr Asn Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105     


<210>  81
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  81

Asp Leu Asn Lys Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser 
1               5                   10                  15      


Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala 
            20                  25                  30          


Thr Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly 
        35                  40                  45              


Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Pro Leu Lys Glu 
    50                  55                  60                  


Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg 
65                  70                  75                  80  


Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln 
                85                  90                  95      


Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg 
            100                 105                 110         


Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala 
        115                 120                 125             


Asp Cys Gly Phe Thr Ser Val Ser Tyr Gln Gln Gly Val Leu Ser Ala 
    130                 135                 140                 


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
145                 150                 155                 160 


Leu Val Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Phe 
                165                 170                 175     


<210>  82
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  82
gggcttggtg atctgcctcg                                                   20


