                         SEQUENCE LISTING

<110>  DiMarchi, Richard
 
<120>  A NOVEL KLOTHO INTERACTION SITE IN THE C-TERMINUS OF FGF23

<130>  32993-348560

<150>  63/105,965
<151>  2020-10-27

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser 
            20                  25      


<210>  2
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val 
1               5                   10                  15      


Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr 
            20                  25              


<210>  3
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro 
            20                  25                  30          


Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val 
        35                  40                  45              


Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly 
    50                  55                  60                  


Cys Arg Pro Phe Ala Lys Phe Ile 
65                  70          


<210>  4
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg His Thr Arg Ser 
1               5                   10                  15      


Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg 
            20                  25                  30          


Ala Arg Met Thr Pro Ala Pro Ala Ser 
        35                  40      


<210>  5
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val 
1               5                   10                  15      


Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly 
            20                  25                  30          


Cys Arg Pro Phe Ala Lys Phe Ile 
        35                  40  


<210>  6
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Ser Ala Glu Asp Asp Ser Pro Met Ala Ser Asp Pro Leu Asn Val Leu 
1               5                   10                  15      


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser 
            20                  25              


<210>  7
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Gly 
1               5                   10                  15      


Gly Arg Val Asn Thr Pro Ala Pro Ala Ser 
            20                  25      


<210>  8
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr His Ala Gly Gly Thr 
            20                  25      


<210>  9
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Ser Ala Glu Asp Asp Ser Glu Arg Ala Ser Asp Pro Leu Asn Val Leu 
1               5                   10                  15      


Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser 
            20                  25              


<210>  10
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Ser Ala Glu Asp Asn Ser Glu Arg Asp Pro Leu Gly Val Val Arg Gly 
1               5                   10                  15      


Gly Arg Val Asn Thr His Ala Gly Gly Thr 
            20                  25      


<210>  11
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val 
1               5                   10                  15      


Arg Pro Arg Ala Arg Met Thr His Ala Gly Gly Thr 
            20                  25              


<210>  12
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val 
1               5                   10                  15      


Arg Gly Gly Arg Val Asn Thr Pro Ala Pro Ala Ser 
            20                  25              


<210>  13
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Glu Arg Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met 
1               5                   10                  


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14

Asp Pro Leu Asn Val Leu Lys Pro Arg Ala Arg Met 
1               5                   10          


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15

Pro Met Ala Ser Asp Pro Leu Gly Val Val Arg Pro Arg Ala Arg Met 
1               5                   10                  15      


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16

Ala Ser Asp Pro Leu Gly Val Val Arg Pro Arg Ala Arg Met 
1               5                   10                  


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17

Asp Pro Leu Gly Val Val Arg Pro Arg Ala Arg Met 
1               5                   10          


<210>  18
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18

Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Gly Pro Glu Gly Cys 
            20                  25                  30      


<210>  19
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19

Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val 
1               5                   10                  15      


Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly 
            20                  25                  30          


Cys 
    


<210>  20
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20

Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val 
1               5                   10                  15      


Arg Pro Arg Ala Arg Met Thr His Ala Gly Gly Thr Gly Pro Glu Gly 
            20                  25                  30          


Cys 
    


<210>  21
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21

Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Ala Pro Leu Gly Val Val 
1               5                   10                  15      


Arg Pro Arg Ala Arg Met Thr His Ala Gly Gly Thr Gly Pro Glu Gly 
            20                  25                  30          


Cys 
    


<210>  22
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22

Ser Ala Glu Asp Asp Ser Glu Arg Ala Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser 
            20                  25      


<210>  23
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23

Ser Ala Glu Asp Asp Ser Glu Arg Ala Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser 
            20                  25      


<210>  24
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24

Ser Ala Glu Asp Asp Ser Glu Arg Ala Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro 
            20                  25                  30          


Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly Val Val 
        35                  40                  45              


Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly 
    50                  55                  60                  


Cys Arg Pro Phe Ala Lys Phe Ile 
65                  70          


<210>  25
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25

Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro 
            20                  25                  30          


Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Ala Pro Leu Gly Val Val 
        35                  40                  45              


Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly 
    50                  55                  60                  


Cys Arg Pro Phe Ala Lys Phe Ile 
65                  70          


<210>  26
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26

Ser Ala Glu Asp Asp Ser Glu Arg Ala Pro Leu Asn Val Leu Lys Pro 
1               5                   10                  15      


Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu Leu Pro 
            20                  25                  30          


Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Ala Pro Leu Gly Val Val 
        35                  40                  45              


Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro Glu Gly 
    50                  55                  60                  


Cys Arg Pro Phe Ala Lys Phe Ile 
65                  70          


<210>  27
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  27

Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val Thr Gly Leu 
1               5                   10                  15      


Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
            20                  25      


<210>  28
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  28

Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met Val Gly Pro Ser 
1               5                   10                  15      


Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            20                  25  


<210>  29
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  29

Met Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val 
1               5                   10                  15      


Cys Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu 
            20                  25                  30          


Gly Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg 
        35                  40                  45              


Asn Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala 
    50                  55                  60                  


Pro His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala 
65                  70                  75                  80  


Gly Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met 
                85                  90                  95      


Asp Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn 
            100                 105                 110         


Cys Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His 
        115                 120                 125             


Ser Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala 
    130                 135                 140                 


Phe Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg 
145                 150                 155                 160 


Arg Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg 
                165                 170                 175     


His Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val 
            180                 185                 190         


Leu Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln 
        195                 200                 205             


Glu Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu 
    210                 215                 220                 


Gly Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly 
225                 230                 235                 240 


Pro Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
                245                 250     


<210>  30
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Tyr Pro Asn Ala Ser Pro Leu Leu Gly Ser Ser Trp Gly Gly Leu Ile 
1               5                   10                  15      


His Leu Tyr Thr Ala Thr Ala Arg Asn Ser Tyr His Leu Gln Ile His 
            20                  25                  30          


Lys Asn Gly His Val Asp Gly Ala Pro His Gln Thr Ile Tyr Ser Ala 
        35                  40                  45              


Leu Met Ile Arg Ser Glu Asp Ala Gly Phe Val Val Ile Thr Gly Val 
    50                  55                  60                  


Met Ser Arg Arg Tyr Leu Cys Met Asp Phe Arg Gly Asn Ile Phe Gly 
65                  70                  75                  80  


Ser His Tyr Phe Asp Pro Glu Asn Cys Arg Phe Gln His Gln Thr Leu 
                85                  90                  95      


Glu Asn Gly Tyr Asp Val Tyr His Ser Pro Gln Tyr His Phe Leu Val 
            100                 105                 110         


Ser Leu Gly Arg Ala Lys Arg Ala Phe Leu Pro Gly Met Asn Pro Pro 
        115                 120                 125             


Pro Tyr Ser Gln Phe Leu Ser Arg Arg Asn Glu Ile Pro Leu Ile His 
    130                 135                 140                 


Phe Asn Thr Pro Ile Pro Arg Arg His Thr Arg 
145                 150                 155 


