                         SEQUENCE LISTING

<110>  A2 Biotherapeutics, Inc.
 
<120>  POLYPEPTIDES TARGETING HPV PEPTIDE-MHC COMPLEXES AND METHODS OF 
       USE THEREOF

<130>  A2BI-025/01WO 331656-2084

<150>  63/105,794
<151>  2020-10-26

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Human papillomavirus

<400>  1

Thr Ile His Asp Ile Ile Leu Glu Cys Val 
1               5                   10  


<210>  2
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VH-1

<400>  2

Asp Tyr Ala Met His 
1               5   


<210>  3
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VH-2

<400>  3

Gly Ile Ser Trp Asn Asp Ala Ser Ile Gly Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  4
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VH-3

<400>  4

Asp Leu Arg Gly Ser Pro Phe Tyr Gly Gly Ala Phe Cys Ile 
1               5                   10                  


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VH-1

<400>  5

Val Tyr Trp Met His 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VH-2

<400>  6

Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VH-3

<400>  7

Glu Asn Gly Val Val Lys Trp Tyr Phe Asp Leu 
1               5                   10      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VL-1

<400>  8

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VL-2

<400>  9

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VL-3

<400>  10

Gln Gln Ser Tyr Ser Tyr Val Thr Pro Leu Thr 
1               5                   10      


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR VL-3

<400>  11

Gln Gln Ser Tyr Ser Thr Pro Ser Glu Ser Thr 
1               5                   10      


<210>  12
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain

<400>  12

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Gly Ser Pro Phe Tyr Gly Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  13
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Tyr Val Thr 
                85                  90                  95      


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Gly Val Val Lys Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ser 
                85                  90                  95      


Glu Ser Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  16
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH domain

<400>  16

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Asp Ala Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Leu Arg Gly Ser Pro Phe Tyr Gly Gly Ala Phe Cys Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  17
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL domain

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Gly Glu Val Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Gly Val Val Lys Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  18
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  signal peptide

<400>  18

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  19
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor

<400>  19

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ser Gly Ile Ser Trp Asn Asp Ala Ser Ile Gly Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Ala Lys Asp Leu Arg Gly Ser Pro Phe Tyr Gly Gly Ala 
        115                 120                 125             


Phe Cys Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp 
145                 150                 155                 160 


Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
                165                 170                 175     


Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu 
            180                 185                 190         


Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        195                 200                 205             


Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 
225                 230                 235                 240 


Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Tyr Val Thr Pro 
                245                 250                 255     


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val 
305                 310                 315                 320 


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
                325                 330                 335     


Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr 
            340                 345                 350         


Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln 
        355                 360                 365             


Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly 
    370                 375                 380                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
385                 390                 395                 400 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                405                 410                 415     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            420                 425                 430         


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        435                 440                 445             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    450                 455                 460                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
465                 470                 475                 480 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                485                 490                 495     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            500                 505                 510         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        515                 520                 525             


Met Gln Ala Leu Pro Pro Arg 
    530                 535 


<210>  20
<211>  532
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  chimeric antigen receptor

<400>  20

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Gly 
        35                  40                  45              


Glu Val Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Val Trp Val Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Asn Gly Val Val Lys Trp Tyr Phe Asp Leu 
        115                 120                 125             


Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
145                 150                 155                 160 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
                165                 170                 175     


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
            180                 185                 190         


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
        195                 200                 205             


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ser Glu Ser Thr Phe 
                245                 250                 255     


Gly Gly Gly Thr Lys Val Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg 
            260                 265                 270         


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
        275                 280                 285             


Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
    290                 295                 300                 


Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val 
305                 310                 315                 320 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                325                 330                 335     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            340                 345                 350         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        355                 360                 365             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
    370                 375                 380                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
385                 390                 395                 400 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                405                 410                 415     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            420                 425                 430         


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        435                 440                 445             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    450                 455                 460                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
465                 470                 475                 480 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                485                 490                 495     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            500                 505                 510         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        515                 520                 525             


Leu Pro Pro Arg 
    530         


<210>  21
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8-alpha hinge

<400>  21

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  22
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8-alpha hinge

<400>  22
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  23
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge

<400>  23

Cys Thr Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
1               5                   10                  15      


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40      


<210>  24
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 hinge

<400>  24
tgtaccattg aagttatgta tcctcctcct tacctagaca atgagaagag caatggaacc       60

attatccatg tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag      120

ccc                                                                    123


<210>  25
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3zeta activation domain

<400>  25

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  26
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3zeta activation domain

<400>  26
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gcgtagaggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggactca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  27
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  27

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  28
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  28
aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg      120

agc                                                                    123


<210>  29
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  29

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  30
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  30
ttctgggtgc tggtcgttgt gggcggcgtg ctggcctgct acagcctgct ggtgacagtg       60

gccttcatca tcttttgggt g                                                 81


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  31

Thr Ile His Asp Ile Ile Leu Glu Cys 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  32

His Leu Asp Lys Lys Gln Arg Phe His 
1               5                   


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  33

Ile Val Tyr Arg Asp Gly Asn Pro Tyr 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human papillomavirus peptide

<400>  34

Leu Met Gly Thr Leu Gly Ile Val 
1               5               


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  35

Thr Thr Leu Glu Gln Gln Tyr Asn Lys 
1               5                   


<210>  36
<211>  160
<212>  PRT
<213>  Human papillomavirus

<400>  36

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys 
            100                 105                 110         


Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu 
        115                 120                 125             


Asp Lys Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg 
    130                 135                 140                 


Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155                 160 


<210>  37
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  37

Tyr Asn Lys Pro Leu Cys Asp Leu Leu 
1               5                   


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  38

Arg Gly Arg Trp Thr Gly Arg Cys 
1               5               


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  39

Ala Phe Arg Asp Leu Cys Ile Val Tyr 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  40

Val Tyr Arg Asp Gly Asn Pro Tyr Ala 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  41

Tyr Arg Asp Gly Asn Pro Tyr Ala Val 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  42

Met Leu Asp Leu Gln Pro Glu Thr Thr 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  43

Thr Leu His Glu Tyr Met Leu Asp Leu 
1               5                   


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  44

Thr Leu Glu Asp Leu Leu Met Gly Thr Leu 
1               5                   10  


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  45

Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  46

His Val Asp Ile Arg Thr Leu Glu Asp Leu 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide probe

<400>  47

Arg Thr Leu Glu Asp Leu Leu Met Gly Thr 
1               5                   10  


<210>  48
<211>  160
<212>  PRT
<213>  Human papillomavirus

<400>  48

Met Ala Arg Phe Glu Asp Pro Thr Arg Arg Pro Tyr Lys Leu Pro Asp 
1               5                   10                  15      


Leu Cys Thr Glu Leu Asn Thr Ser Leu Gln Asp Ile Glu Ile Thr Cys 
            20                  25                  30          


Val Tyr Cys Lys Thr Val Leu Glu Leu Thr Glu Val Phe Glu Phe Ala 
        35                  40                  45              


Phe Lys Asp Leu Phe Val Val Tyr Arg Asp Ser Ile Pro His Ala Ala 
    50                  55                  60                  


Cys His Lys Cys Ile Asp Phe Tyr Ser Arg Ile Arg Glu Leu Arg His 
65                  70                  75                  80  


Tyr Ser Asp Ser Val Tyr Gly Asp Thr Leu Glu Lys Leu Thr Asn Thr 
                85                  90                  95      


Asn Thr Gly Leu Tyr Asn Leu Leu Ile Arg Cys Leu Arg Cys Gln Lys 
            100                 105                 110         


Pro Leu Asn Pro Ala Glu Lys Leu Arg His Leu Asn Glu Lys Arg Arg 
        115                 120                 125             


Phe His Asn Ile Ala Gly His Tyr Arg Gly Gln Cys His Ser Cys Cys 
    130                 135                 140                 


Asn Arg Ala Arg Gln Glu Arg Leu Gln Arg Arg Arg Glu Thr Gln Val 
145                 150                 155                 160 


<210>  49
<211>  98
<212>  PRT
<213>  Human papillomavirus

<400>  49

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  50
<211>  105
<212>  PRT
<213>  Human papillomavirus

<400>  50

Met His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
1               5                   10                  15      


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
            20                  25                  30          


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
        35                  40                  45              


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
    50                  55                  60                  


Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
                85                  90                  95      


Val Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 105 


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  51

Thr Ile Thr Asp Ile Ile Ser Ala Leu Val 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  52

Thr Ile Thr Asp Ile Cys Phe Glu Asn Val 
1               5                   10  


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  53

Thr Ile Phe Val Ile Ile Leu Ala Ser Val 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  54

Thr Ile Ser Asp Ile Asp Ala Glu Asp Val 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  55

Thr Ser Glu Asp Leu Trp Leu Glu Cys Val 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  56

Thr Ser Pro Asp Ile Leu Leu Glu Glu Val 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  57

Thr Gln Gly Asp Ser Ile Leu Asp Cys Val 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  58

Phe Ile His Asp Ala Leu Leu Glu Ala Val 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  59

Ile Ile His Asp Phe Ile Leu Glu Ala Thr 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  60

Thr Ile Ser Asp Thr Ile Leu Glu Val Gly 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  61

Thr Ile Ala Asp Ile Ile Arg Thr Cys Leu 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  62

Thr Ile Ala Glu Ile Ile Glu Glu Cys Gly 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  63

Thr Leu Ser Asp Ile Tyr Leu Asn Asn Val 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  64

Thr Leu His Ser Arg Phe Leu Glu Gly Val 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  65

Thr Leu His Gly Lys Ile Leu Asn Gly Val 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  66

Leu Leu Phe Asp Ile Phe Leu Glu Thr Val 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  67

Ile Leu His Ser Ile Tyr Leu Cys Cys Val 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  68

Thr Leu Leu Leu Ile Ile Leu Thr Asp Val 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  69

Thr Leu Val Ser Gln Glu Leu Glu Cys Val 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  70

Thr Met Thr Lys Ile Ile Gly Asn Cys Val 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  71

His Leu Phe Asp Ile Ile Leu Thr Ser Val 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  72

Thr Leu Asn Asp Gln Thr Leu Glu Asn Val 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  73

Leu Leu Thr Lys Ile Ile Leu Glu His Val 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  74

Val Leu Ile Asp Ile Ile Leu Thr Ser Val 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  75

Thr Leu Lys Arg Glu Ile Leu Glu Asp Val 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  76

Glu Leu Met Asp Ile Ile Ala Glu Asn Val 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  77

Ser Met Leu Asp Glu Ile Leu Glu Asp Val 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  78

Asn Leu Val Asp Gln Ile Leu Glu Ser Val 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  79

Thr Leu Ile Ala Val Thr Leu Glu Cys Val 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  80

Thr Leu Thr Glu Ile Ile Leu Leu Ser Val 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  81

Thr Leu Tyr Ser Val Ile Leu Phe Cys Val 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  82

Ser Leu Gln Gly Ile Ile Leu Glu Thr Val 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  83

Tyr Leu His Asp Val Ile Leu Arg Val Val 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  84

Asp Met His Ser Ile Ile Val Ser Cys Val 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  85

Thr Leu His Ser Ile Ile Ile Ser Leu Val 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  86

Thr Leu Asn Asp Gln Leu Leu Glu Lys Val 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  87

Asp Leu Asp Glu Leu Ile Leu Glu Cys Val 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  88

Thr Met Ala Asp Val Leu Leu Glu Glu Val 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  89

Asn Leu His Asp Ile Leu Leu Arg Asp Val 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  90

Lys Leu His Asp Ala Ile Val Glu Val Val 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  91

Ile Ile Ile His Asp Phe Ile Leu Glu Ala 
1               5                   10  


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  92

Ile Ile His Asp Phe Ile Leu Glu Ala 
1               5                   


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  93

Phe Ile His Asp Ala Leu Leu Glu Ala 
1               5                   


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  94

Phe Ile His Asp Ala Leu Leu Glu Ala Ile 
1               5                   10  


<210>  95
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  95

Tyr Ile Phe Ile His Asp Ala Leu Leu 
1               5                   


<210>  96
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  96

Phe Ile His Asp Ala Ile Leu Glu Ala 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  97

Tyr Val Phe Ile His Asp Ala Ile Leu 
1               5                   


<210>  98
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  near off target peptide

<400>  98

Tyr Ile Phe Ile His Asp Ala Ile Leu 
1               5                   


