                         SEQUENCE LISTING

<110>  BioLegend, Inc.
 
<120>  ANTI-NKG2A AGENTS AND COMPOSITIONS AND METHODS FOR MAKING AND 
       USING THE SAME 

<130>  BLD013PCT1

<150>  63/107,812
<151>  2020-10-30

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR)

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Val Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Phe Glu Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Gly Ile Trp Asp Tyr Asp Gly Phe Ala Asp Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  2
<211>  70
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human NKG2A cytoplsmic domain

<400>  2

Met Asp Asn Gln Gly Val Ile Tyr Ser Asp Leu Asn Leu Pro Pro Asn 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Asn Ser Ile Leu 
            20                  25                  30          


Ala Thr Glu Gln Glu Ile Thr Tyr Ala Glu Leu Asn Leu Gln Lys Ala 
        35                  40                  45              


Ser Gln Asp Phe Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Asp Leu 
    50                  55                  60                  


Pro Ser Ala Pro Glu Lys 
65                  70  


<210>  3
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR)

<400>  3

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Val Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Tyr Phe Glu Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Val Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gln Gly Ile Trp Asp Tyr Asp Gly Phe Ala Asp Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  4
<211>  124
<212>  PRT
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR)

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Tyr Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Tyr Gly Gly Ile Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Thr Ala Lys Asn Asn Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Asp Thr Ser Val Tyr Val Asn Tyr Tyr Thr Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 


<210>  5
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR)

<400>  5

Gln Ile Val Phe Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  6
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human NKG2A transmembrane domain

<400>  6

Leu Ile Val Gly Ile Leu Gly Ile Ile Cys Leu Ile Leu Met Ala Ser 
1               5                   10                  15      


Val Val Thr Ile Val Val Ile 
            20              


<210>  7
<211>  140
<212>  PRT
<213>  artificial sequence

<220>
<223>  Human NKG2A extracellular domain

<400>  7

Pro Ser Thr Leu Ile Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg 
1               5                   10                  15      


Thr Gln Lys Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr 
            20                  25                  30          


Tyr Ser Asn Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu 
        35                  40                  45              


Glu Ser Leu Leu Ala Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile 
    50                  55                  60                  


Asp Asn Glu Glu Glu Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser 
65                  70                  75                  80  


Trp Ile Gly Val Phe Arg Asn Ser Ser His His Pro Trp Val Thr Met 
                85                  90                  95      


Asn Gly Leu Ala Phe Lys His Glu Ile Lys Asp Ser Asp Asn Ala Glu 
            100                 105                 110         


Leu Asn Cys Ala Val Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys 
        115                 120                 125             


Gly Ser Ser Ile Ile Tyr His Cys Lys His Lys Leu 
    130                 135                 140 


<210>  8
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR)

<400>  8

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Thr Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Ile His Trp Tyr Gln Gln Arg Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  9
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH1

<400>  9

Ser Tyr Trp Met Asn 
1               5   


<210>  10
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH2

<400>  10

Arg Ile Tyr Phe Glu Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  11
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH3

<400>  11

Gln Gly Ile Trp Asp Tyr Asp Gly Phe Ala Asp 
1               5                   10      


<210>  12
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL1

<400>  12

Ser Ala Ser Ser Ser Val Thr Tyr Met His 
1               5                   10  


<210>  13
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL2

<400>  13

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL3

<400>  14

Gln Gln Arg Ser Ser Tyr Pro Tyr Thr 
1               5                   


<210>  15
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH2

<400>  15

Arg Ile Tyr Phe Glu Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  16
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH1

<400>  16

Asp Tyr Tyr Met Tyr 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH2

<400>  17

Thr Ile Ser Tyr Gly Gly Ile Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH3

<400>  18

Asp Arg Asp Thr Ser Val Tyr Val Asn Tyr Tyr Thr Met Asp Tyr 
1               5                   10                  15  


<210>  19
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL1

<400>  19

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Ile His 
1               5                   10                  15  


<210>  20
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL2

<400>  20

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL3

<400>  21

Gln His Ser Arg Glu Leu Pro Leu Thr 
1               5                   


<210>  22
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH1


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is S or D

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is W or Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is N or Y

<400>  22

Xaa Tyr Xaa Met Xaa 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CDRH2


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is R or T

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is Y or S

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is F or Y

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is E or G

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is D or G

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is G or I

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is D or Y

<220>
<221>  VARIANT
<222>  (10)..(10)
<223>  Xaa is N or Y

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is N or P

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is G or D

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is K or S

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa is F or V

<220>
<221>  VARIANT
<222>  (17)..(17)
<223>  Xaa is G or D

<400>  23

Xaa Ile Xaa Xaa Xaa Xaa Xaa Xaa Thr Xaa Tyr Xaa Xaa Xaa Xaa Lys 
1               5                   10                  15      


Xaa 
    


<210>  24
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRH3


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is Q or D

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is G or R

<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa is D or no amino acid

<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa is T or no amino acid

<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa is S or no amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is V or no amino acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa is I or Y

<220>
<221>  VARIANT
<222>  (8)..(8)
<223>  Xaa is W or V

<220>
<221>  VARIANT
<222>  (9)..(9)
<223>  Xaa is D or N

<220>
<221>  VARIANT
<222>  (11)..(11)
<223>  Xaa is D or Y

<220>
<221>  VARIANT
<222>  (12)..(12)
<223>  Xaa is G or T

<220>
<221>  VARIANT
<222>  (13)..(13)
<223>  Xaa is F or M

<220>
<221>  VARIANT
<222>  (14)..(14)
<223>  Xaa is A or D

<220>
<221>  VARIANT
<222>  (15)..(15)
<223>  Xaa is D or Y

<400>  24

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL1


<220>
<221>  variant
<222>  (1)..(1)
<223>  Xaa is S or R

<220>
<221>  variant
<222>  (4)..(4)
<223>  Xaa is S or K

<220>
<221>  variant
<222>  (7)..(7)
<223>  Xaa is T or S

<220>
<221>  variant
<222>  (8)..(8)
<223>  Xaa is T or no amino acid

<220>
<221>  variant
<222>  (9)..(9)
<223>  Xaa is S or no amino acid

<220>
<221>  variant
<222>  (10)..(10)
<223>  Xaa is G or no amino acid

<220>
<221>  variant
<222>  (11)..(11)
<223>  Xaa is Y or no amino acid

<220>
<221>  variant
<222>  (12)..(12)
<223>  Xaa is S or no amino acid

<220>
<221>  variant
<222>  (14)..(14)
<223>  Xaa is M or I

<400>  25

Xaa Ala Ser Xaa Ser Val Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa His 
1               5                   10                  15  


<210>  26
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDRL2


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Xaa is S or L

<220>
<221>  VARIANT
<222>  (2)..(2)
<223>  Xaa is T or A

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa is A or E

<400>  26

Xaa Xaa Ser Asn Leu Xaa Ser 
1               5           


<210>  27
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  CDRL3


<220>
<221>  variant
<222>  (2)..(2)
<223>  Xaa is Q or H

<220>
<221>  variant
<222>  (3)..(3)
<223>  Xaa is R or S

<220>
<221>  variant
<222>  (4)..(4)
<223>  Xaa is S or R

<220>
<221>  variant
<222>  (5)..(5)
<223>  Xaa is S or E

<220>
<221>  variant
<222>  (6)..(6)
<223>  Xaa is Y or L

<220>
<221>  variant
<222>  (8)..(8)
<223>  Xaa is Y or L

<400>  27

Gln Xaa Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  28
<211>  233
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human NKG2A

<400>  28

Met Asp Asn Gln Gly Val Ile Tyr Ser Asp Leu Asn Leu Pro Pro Asn 
1               5                   10                  15      


Pro Lys Arg Gln Gln Arg Lys Pro Lys Gly Asn Lys Asn Ser Ile Leu 
            20                  25                  30          


Ala Thr Glu Gln Glu Ile Thr Tyr Ala Glu Leu Asn Leu Gln Lys Ala 
        35                  40                  45              


Ser Gln Asp Phe Gln Gly Asn Asp Lys Thr Tyr His Cys Lys Asp Leu 
    50                  55                  60                  


Pro Ser Ala Pro Glu Lys Leu Ile Val Gly Ile Leu Gly Ile Ile Cys 
65                  70                  75                  80  


Leu Ile Leu Met Ala Ser Val Val Thr Ile Val Val Ile Pro Ser Thr 
                85                  90                  95      


Leu Ile Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys 
            100                 105                 110         


Ala Arg His Cys Gly His Cys Pro Glu Glu Trp Ile Thr Tyr Ser Asn 
        115                 120                 125             


Ser Cys Tyr Tyr Ile Gly Lys Glu Arg Arg Thr Trp Glu Glu Ser Leu 
    130                 135                 140                 


Leu Ala Cys Thr Ser Lys Asn Ser Ser Leu Leu Ser Ile Asp Asn Glu 
145                 150                 155                 160 


Glu Glu Met Lys Phe Leu Ser Ile Ile Ser Pro Ser Ser Trp Ile Gly 
                165                 170                 175     


Val Phe Arg Asn Ser Ser His His Pro Trp Val Thr Met Asn Gly Leu 
            180                 185                 190         


Ala Phe Lys His Glu Ile Lys Asp Ser Asp Asn Ala Glu Leu Asn Cys 
        195                 200                 205             


Ala Val Leu Gln Val Asn Arg Leu Lys Ser Ala Gln Cys Gly Ser Ser 
    210                 215                 220                 


Ile Ile Tyr His Cys Lys His Lys Leu 
225                 230             


<210>  29
<211>  217
<212>  PRT
<213>  artificial sequence

<220>
<223>  CH2-CH3 portion of Fc

<400>  29

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  30
<211>  417
<212>  DNA
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR) 
WITH SIGNAL SEQUENCE

<400>  30
atgggatgga gccggatctt tctcttcctc ctgtcaataa ctgcaggtgt ccattgccag       60

gtccagctgc agcagtctgg acctgagctg gtgaagcctg gggcctcagt gaagatttcc      120

tgcaaagctt ctggctacgt atttagcagt tattggatga actgggtgaa gcagaggcct      180

ggacagggtc ttgagtggat tggacggatt tattttgaag atggagatac taactacaat      240

gggaaattca agggcaaggc cacactgact gcagacaaat cttccagcac agcctacatg      300

cagctcagta gcctgacctc tgtggactct gcggtctatt tctgtgcaag acaggggata      360

tgggattacg acgggtttgc tgactggggc caagggactc tggtcactgt ctctgca         417


<210>  31
<211>  417
<212>  DNA
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR) 

WITH SIGNAL SEQUENCE

<400>  31
atgggatgga gccggatctt tctcttcctc ctgtcaataa ctgcaggtgt ccattgccag       60

gtccagctgc agcagtctgg acctgagctg gtgaagcctg gggcctcagt gaagatttcc      120

tgcaaagctt ctggctacgt atttagtagt tattggatga actgggtgaa gcagaggcct      180

ggacagggtc ttgagtggat tggacggatt tattttgaag atggagatac taactacaat      240

gggaagttca agggcaaggc cacactgact gcagacaaat cttccagcac agcctacatg      300

cagctcagca gcctgacctc tgtggactct gcggtctatt tctgtgcaag acaggggata      360

tgggattacg acgggtttgc tgactggggc caagggactc tggtcactgt ctctgca         417


<210>  32
<211>  417
<212>  DNA
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR) 
WITH SIGNAL SEQUENCE

<400>  32
atgggatgga gccggatctt tctcttcctc ctgtcaataa ctgcaggtgt ccattgccag       60

gtccagttgc agcagtctgg acctgagctg gtgaagcctg gggcctcagt gaagatttcc      120

tgcaaagctt ctggctacgt atttagcagt tattggatga actgggtgaa gcagaggcct      180

ggacagggtc ttgagtggat tggacggatt tattttgaag atggagatac taactacaat      240

gggaagttca aggacaaggc cacactgact gcagacaaat cttccagcac agcctacatg      300

cagctcagta gcctgacctc tgtggactct gcggtctatt tctgtgcaag acaggggata      360

tgggattacg acgggtttgc tgactggggc caagggactc tggtcactgt ctctgca         417


<210>  33
<211>  429
<212>  DNA
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR) 
WITH SIGNAL SEQUENCE

<400>  33
atgaacttcg ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgcagctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtgac tattacatgt attgggttcg ccagactccg      180

gaaaagaggc tggagtgggt cgcaaccatt agttatggtg gtatttacac ctactatcca      240

gacagtgtga aggggcggtt caccatctcc agagacactg ccaagaacaa cctgtacctg      300

caaatgagca gtctgaagtc tgaggacaca gccgtgtatt actgtgcaag agatcgggac      360

acctcggtct acgtgaatta ctatactatg gactactggg gtcaaggaac ctcagtcacc      420

gtctcctca                                                              429


<210>  34
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR)

<400>  34
caggtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgtatttagc agttattgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacgg atttattttg aagatggaga tactaactac      180

aatgggaaat tcaagggcaa ggccacactg actgcagaca aatcttccag cacagcctac      240

atgcagctca gtagcctgac ctctgtggac tctgcggtct atttctgtgc aagacagggg      300

atatgggatt acgacgggtt tgctgactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  35
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR)

<400>  35
caggtccagc tgcagcagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgtatttagt agttattgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacgg atttattttg aagatggaga tactaactac      180

aatgggaagt tcaagggcaa ggccacactg actgcagaca aatcttccag cacagcctac      240

atgcagctca gcagcctgac ctctgtggac tctgcggtct atttctgtgc aagacagggg      300

atatgggatt acgacgggtt tgctgactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  36
<211>  360
<212>  DNA
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR)

<400>  36
caggtccagt tgcagcagtc tggacctgag ctggtgaagc ctggggcctc agtgaagatt       60

tcctgcaaag cttctggcta cgtatttagc agttattgga tgaactgggt gaagcagagg      120

cctggacagg gtcttgagtg gattggacgg atttattttg aagatggaga tactaactac      180

aatgggaagt tcaaggacaa ggccacactg actgcagaca aatcttccag cacagcctac      240

atgcagctca gtagcctgac ctctgtggac tctgcggtct atttctgtgc aagacagggg      300

atatgggatt acgacgggtt tgctgactgg ggccaaggga ctctggtcac tgtctctgca      360


<210>  37
<211>  372
<212>  DNA
<213>  artificial sequence

<220>
<223>  Heavy Chain Variable Region (HCVR)

<400>  37
gaagtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt gactattaca tgtattgggt tcgccagact      120

ccggaaaaga ggctggagtg ggtcgcaacc attagttatg gtggtattta cacctactat      180

ccagacagtg tgaaggggcg gttcaccatc tccagagaca ctgccaagaa caacctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccgtgt attactgtgc aagagatcgg      300

gacacctcgg tctacgtgaa ttactatact atggactact ggggtcaagg aacctcagtc      360

accgtctcct ca                                                          372


<210>  38
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR) 
WITH SIGNAL SEQUENCE

<400>  38
atgcattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacaaa ttgttttcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag      120

gtcaccataa cctgcagtgc cagctcaagt gtcacttaca tgcactggtt ccagcagaag      180

ccaggcactt ctcccaaact ctggatttat agcacatcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg atctgggacc tcttactctc tcacaatcag ccgaatggag      300

gctgaagatg ctgccactta ttactgccag caaaggagta gttacccata cacgttcgga      360

ggggggacca agctggaaat aaaa                                             384


<210>  39
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR) 
WITH SIGNAL SEQUENCE

<400>  39
atgcattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacaaa ttgttttcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag      120

gtcaccataa cctgcagtgc cagctcaagt gtcacttaca tgcactggtt ccagcagaag      180

ccaggcactt ctcccaaact ctggatttat agcacatcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg atctgggacc tcttactctc tcacaatcag ccgaatggag      300

gctgaagatg ctgccactta ttactgccag caaaggagta gttacccata cacgttcgga      360

ggggggacca agctggaaat aaaa                                             384


<210>  40
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR) 
WITH SIGNAL SEQUENCE

<400>  40
atgcattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agaggacaaa ttgttttcac ccagtctcca gcaatcatgt ctgcatctcc aggggagaag      120

gtcaccataa cctgcagtgc cagctcaagt gtcacttaca tgcactggtt ccagcagaag      180

ccaggcactt ctcccaaact ctggatttat agcacatcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg atctgggacc tcttactctc tcacaatcag ccgaatggag      300

gctgaagatg ctgccactta ttactgccag caaaggagta gttacccata cacgttcgga      360

ggggggacca agctggaaat aaaa                                             384


<210>  41
<211>  393
<212>  DNA
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR) 
WITH SIGNAL SEQUENCE

<400>  41
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccactggt       60

gacattgtgc tgacacagtc tcctgtttcc ttaactgtat ctctggggca gagggccacc      120

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat acactggtac      180

caacagagac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      240

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caatatccat      300

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttcctctc      360

acgttcggtg ctgggaccaa gctggagctg aaa                                   393


<210>  42
<211>  318
<212>  DNA
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR)

<400>  42
caaattgttt tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgccagctc aagtgtcact tacatgcact ggttccagca gaagccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttacc catacacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  43
<211>  318
<212>  DNA
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR)

<400>  43
caaattgttt tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgccagctc aagtgtcact tacatgcact ggttccagca gaagccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttacc catacacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  44
<211>  318
<212>  DNA
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR)

<400>  44
caaattgttt tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

ataacctgca gtgccagctc aagtgtcact tacatgcact ggttccagca gaagccaggc      120

acttctccca aactctggat ttatagcaca tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggca gtggatctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcaaagg agtagttacc catacacgtt cggagggggg      300

accaagctgg aaataaaa                                                    318


<210>  45
<211>  333
<212>  DNA
<213>  artificial sequence

<220>
<223>  Light chain variable region (LCVR)

<400>  45
gacattgtgc tgacacagtc tcctgtttcc ttaactgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat acactggtac      120

caacagagac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caatatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttcctctc      300

acgttcggtg ctgggaccaa gctggagctg aaa                                   333


<210>  46
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain signal sequence

<400>  46
atggagacag acacactcct gttatgggta ctgctgctct gggttccagg ttccactggt       60


<210>  47
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain signal sequence

<400>  47

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  48
<211>  57
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain signal sequence

<400>  48
atgaacttcg ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgt          57


<210>  49
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain signal sequence

<400>  49

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  50
<211>  66
<212>  DNA
<213>  artificial sequence

<220>
<223>  light chain signal sequence

<400>  50
atgcattttc aagtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtcc       60

agagga                                                                  66


<210>  51
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  light chain signal sequence

<400>  51

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  52
<211>  57
<212>  DNA
<213>  artificial sequence

<220>
<223>  heavy chain signal sequence

<400>  52
atgggatgga gccggatctt tctcttcctc ctgtcaataa ctgcaggtgt ccattgc          57


<210>  53
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  heavy chain signal sequence

<400>  53

Met Gly Trp Ser Arg Ile Phe Leu Phe Leu Leu Ser Ile Thr Ala Gly 
1               5                   10                  15      


Val His Cys 
            


