                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  INTERLEUKIN-17 INHIBITORS

<130>  58979-WO-PCT

<150>  EP20205121.5
<151>  2020.11.02

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  6829
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NPL012065 - SEQ ID NO: 1

<400>  1
ttggccatta gccatattat tcattggtta tatagcataa atcaatattg gctattggcc       60

attgcatacg ttgtatctat atcataatat gtacatttat attggctcat gtccaatatg      120

accgccatgt tggcattgat tattgactag ttattaatag taatcaatta cggggtcatt      180

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg      240

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac      300

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt      360

ggcagtacat caagtgtatc atatgccaag tccgccccct attgacgtca atgacggtaa      420

atggcccgcc tggcattatg cccagtacat gaccttacgg gactttccta cttggcagta      480

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acaccaatgg      540

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg      600

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaata accccgcccc      660

gttgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctcgttt      720

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagaca      780

ccgggaccga tccagcctcc gcggccggga acggtgcatt ggaacgcgga ttccccgtgc      840

caagagtgac gtaagtaccg cctatagagt ctataggccc acccccttgg cttcgttaga      900

acgcggctac aattaataca taaccttatg tatcatacac atacgattta ggtgacacta      960

tagaataaca tccactttgc ctttctctcc acaggtgtcc actcccaggt ccaactgcac     1020

ggaagcttct gcaggtcgac gccgccacca tgactcctgg gaagacctca ttggtgtcac     1080

tgctactgct gctgagcctg gaggccatag tgaaggcagg aatcacaatc ccacgaaatc     1140

caggatgccc aaattctgag gacaagaact tcccccggac tgtgatggtc aacctgaaca     1200

tccataaccg gaataccaat accaatccca aaaggtcctc agattactac aaccgatcca     1260

cctcaccttg gaatctccac cgcaatgagg accctgagag atatccctct gtgatctggg     1320

aggcaaagtg ccgccacttg ggctgcatca acgctgatgg gaacgtggac taccacatga     1380

actctgtccc catccagcaa gagatcctgg tcctgcgcag ggagcctcca cactgcccca     1440

actccttccg gctggagaag atactggtgt ccgtgggctg cacctgtgtc accccgattg     1500

tcgaattccg tcacgactcc taagcggccg ctctagaggg cccgtttaaa cccgctgatc     1560

agcctcgact gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc     1620

cttgaccctg gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc     1680

gcattgtctg agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg     1740

ggaggattgg gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga     1800

ggcggaaaga accagctagc tcgaggcagg cagaagtatg caaagcatgc atctcaatta     1860

gtcagcaacc aggtgtggaa agtccccagg ctccccagca ggcagaagta tgcaaagcat     1920

gcatctcaat tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac     1980

tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga     2040

ggccgaggcc gcctctgcct ctgagctatt ccagaagtag tgaggaggct tttttggagg     2100

cctaggcttt tgcaaaaagc tcccgggagc ttgtatatcc attttcggat ctgatcagca     2160

cgtgttgaca attaatcatc ggcatagtat atcggcatag tataatacga caaggtgagg     2220

aactaaacca tggccaagtt gaccagtgcc gttccggtgc tcaccgcgcg cgacgtcgcc     2280

ggagcggtcg agttctggac cgaccggctc gggttctccc gggacttcgt ggaggacgac     2340

ttcgccggtg tggtccggga cgacgtgacc ctgttcatca gcgcggtcca ggaccaggtg     2400

gtgccggaca acaccctggc ctgggtgtgg gtgcgcggcc tggacgagct gtacgccgag     2460

tggtcggagg tcgtgtccac gaacttccgg gacgcctccg ggccggccat gaccgagatc     2520

ggcgagcagc cgtgggggcg ggagttcgcc ctgcgcgacc cggccggcaa ctgcgtgcac     2580

ttcgtggccg aggagcagga ctgacacgtg ctacgagatt tcgattccac cgccgccttc     2640

tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat cctccagcgc     2700

ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc ttataatggt     2760

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     2820

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgaatttt gcattaatga     2880

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc     2940

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     3000

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     3060

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     3120

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     3180

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     3240

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa     3300

tgctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     3360

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     3420

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     3480

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     3540

agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     3600

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     3660

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     3720

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     3780

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     3840

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     3900

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata     3960

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg     4020

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct     4080

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt     4140

tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc     4200

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga     4260

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt     4320

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc     4380

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa     4440

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca     4500

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca     4560

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct     4620

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc     4680

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa     4740

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt     4800

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc     4860

gatcgacgga tcgggagatc cgggacatgt acctcccagg ggcccaggaa gactacggga     4920

ggctacacca acgtcaatca gaggggcctg tgtagctacc gataagcgga ccctcaagag     4980

ggcattagca atagtgttta taaggccccc ttgttaaccc taaacgggta gcatatgctt     5040

cccgggtagt agtatatact atccagacta accctaattc aatagcatat gttacccaac     5100

gggaagcata tgctatcgaa ttagggttag taaaagggtc ctaaggaaca gcgatatctc     5160

ccaccccatg agctgtcacg gttttattta catggggtca ggattccacg agggtagtga     5220

accattttag tcacaagggc agtggctgaa gatcaaggag cgggcagtga actctcctga     5280

atcttcgcct gcttcttcat tctccttcgt ttagctaata gaataactgc tgagttgtga     5340

acagtaaggt gtatgtgagg tgctcgaaaa caaggtttca ggtgacgccc ccagaataaa     5400

atttggacgg ggggttcagt ggtggcattg tgctatgaca ccaatataac cctcacaaac     5460

cccttgggca ataaatacta gtgtaggaat gaaacattct gaatatcttt aacaatagaa     5520

atccatgggg tggggacaag ccgtaaagac tggatgtcca tctcacacga atttatggct     5580

atgggcaaca cataatccta gtgcaatatg atactggggt tattaagatg tgtcccaggc     5640

agggaccaag acaggtgaac catgttgtta cactctattt gtaacaaggg gaaagagagt     5700

ggacgccgac agcagcggac tccactggtt gtctctaaca cccccgaaaa ttaaacgggg     5760

ctccacgcca atggggccca taaacaaaga caagtggcca ctcttttttt tgaaattgtg     5820

gagtgggggc acgcgtcagc ccccacacgc cgccctgcgg ttttggactg taaaataagg     5880

gtgtaataac ttggctgatt gtaaccccgc taaccactgc ggtcaaacca cttgcccaca     5940

aaaccactaa tggcaccccg gggaatacct gcataagtag gtgggcgggc caagataggg     6000

gcgcgattgc tgcgatctgg aggacaaatt acacacactt gcgcctgagc gccaagcaca     6060

gggttgttgg tcctcatatt cacgaggtcg ctgagagcac ggtgggctaa tgttgccatg     6120

ggtagcatat actacccaaa tatctggata gcatatgcta tcctaatcta tatctgggta     6180

gcataggcta tcctaatcta tatctgggta gcatatgcta tcctaatcta tatctgggta     6240

gtatatgcta tcctaattta tatctgggta gcataggcta tcctaatcta tatctgggta     6300

gcatatgcta tcctaatcta tatctgggta gtatatgcta tcctaatctg tatccgggta     6360

gcatatgcta tcctaataga gattagggta gtatatgcta tcctaattta tatctgggta     6420

gcatatacta cccaaatatc tggatagcat atgctatcct aatctatatc tgggtagcat     6480

atgctatcct aatctatatc tgggtagcat aggctatcct aatctatatc tgggtagcat     6540

atgctatcct aatctatatc tgggtagtat atgctatcct aatttatatc tgggtagcat     6600

aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc tgggtagtat     6660

atgctatcct aatctgtatc cgggtagcat atgctatcct catgcatata cagtcagcat     6720

atgataccca gtagtagagt gggagtgcta tcctttgcat atgccgccac ctcccaaggg     6780

ggcgtgaatt ttcgctgctt gtccttttcc tgcatgcgga tcttcaata                 6829


<210>  2
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer RS198 - SEQ ID NO: 2

<400>  2
catacgattt aggtga                                                       16


<210>  3
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer RS4930 - SEQ ID NO: 3

<400>  3
cctctagagc ggccgcttag gagtcgtgac ggaattcggc cacatggtgg acaatcgggg       60

tgacacaggt gcac                                                         74


<210>  4
<211>  6841
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NPL016964 - SEQ ID NO: 4


<220>
<221>  APP tag
<222>  (1515)..(1532)
<223>  encoding APP (a.k.a. APP6) tag.

<400>  4
ttggccatta gccatattat tcattggtta tatagcataa atcaatattg gctattggcc       60

attgcatacg ttgtatctat atcataatat gtacatttat attggctcat gtccaatatg      120

accgccatgt tggcattgat tattgactag ttattaatag taatcaatta cggggtcatt      180

agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg gcccgcctgg      240

ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc ccatagtaac      300

gccaataggg actttccatt gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt      360

ggcagtacat caagtgtatc atatgccaag tccgccccct attgacgtca atgacggtaa      420

atggcccgcc tggcattatg cccagtacat gaccttacgg gactttccta cttggcagta      480

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acaccaatgg      540

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg      600

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaata accccgcccc      660

gttgacgcaa atgggcggta ggcgtgtacg gtgggaggtc tatataagca gagctcgttt      720

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagaca      780

ccgggaccga tccagcctcc gcggccggga acggtgcatt ggaacgcgga ttccccgtgc      840

caagagtgac gtaagtaccg cctatagagt ctataggccc acccccttgg cttcgttaga      900

acgcggctac aattaataca taaccttatg tatcatacac atacgattta ggtgacacta      960

tagaataaca tccactttgc ctttctctcc acaggtgtcc actcccaggt ccaactgcac     1020

ggaagcttct gcaggtcgac gccgccacca tgactcctgg gaagacctca ttggtgtcac     1080

tgctactgct gctgagcctg gaggccatag tgaaggcagg aatcacaatc ccacgaaatc     1140

caggatgccc aaattctgag gacaagaact tcccccggac tgtgatggtc aacctgaaca     1200

tccataaccg gaataccaat accaatccca aaaggtcctc agattactac aaccgatcca     1260

cctcaccttg gaatctccac cgcaatgagg accctgagag atatccctct gtgatctggg     1320

aggcaaagtg ccgccacttg ggctgcatca acgctgatgg gaacgtggac taccacatga     1380

actctgtccc catccagcaa gagatcctgg tcctgcgcag ggagcctcca cactgcccca     1440

actccttccg gctggagaag atactggtgt ccgtgggctg cacctgtgtc accccgattg     1500

tccaccatgt ggccgaattc cgtcacgact cctaagcggc cgctctagag ggcccgttta     1560

aacccgctga tcagcctcga ctgtgccttc tagttgccag ccatctgttg tttgcccctc     1620

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     1680

ggaaattgca tcgcattgtc tgagtaggtg tcattctatt ctggggggtg gggtggggca     1740

ggacagcaag ggggaggatt gggaagacaa tagcaggcat gctggggatg cggtgggctc     1800

tatggcttct gaggcggaaa gaaccagcta gctcgaggca ggcagaagta tgcaaagcat     1860

gcatctcaat tagtcagcaa ccaggtgtgg aaagtcccca ggctccccag caggcagaag     1920

tatgcaaagc atgcatctca attagtcagc aaccatagtc ccgcccctaa ctccgcccat     1980

cccgccccta actccgccca gttccgccca ttctccgccc catggctgac taattttttt     2040

tatttatgca gaggccgagg ccgcctctgc ctctgagcta ttccagaagt agtgaggagg     2100

cttttttgga ggcctaggct tttgcaaaaa gctcccggga gcttgtatat ccattttcgg     2160

atctgatcag cacgtgttga caattaatca tcggcatagt atatcggcat agtataatac     2220

gacaaggtga ggaactaaac catggccaag ttgaccagtg ccgttccggt gctcaccgcg     2280

cgcgacgtcg ccggagcggt cgagttctgg accgaccggc tcgggttctc ccgggacttc     2340

gtggaggacg acttcgccgg tgtggtccgg gacgacgtga ccctgttcat cagcgcggtc     2400

caggaccagg tggtgccgga caacaccctg gcctgggtgt gggtgcgcgg cctggacgag     2460

ctgtacgccg agtggtcgga ggtcgtgtcc acgaacttcc gggacgcctc cgggccggcc     2520

atgaccgaga tcggcgagca gccgtggggg cgggagttcg ccctgcgcga cccggccggc     2580

aactgcgtgc acttcgtggc cgaggagcag gactgacacg tgctacgaga tttcgattcc     2640

accgccgcct tctatgaaag gttgggcttc ggaatcgttt tccgggacgc cggctggatg     2700

atcctccagc gcggggatct catgctggag ttcttcgccc accccaactt gtttattgca     2760

gcttataatg gttacaaata aagcaatagc atcacaaatt tcacaaataa agcatttttt     2820

tcactgcatt ctagttgtgg tttgtccaaa ctcatcaatg tatcttatca tgtctgaatt     2880

ttgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     2940

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     3000

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     3060

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     3120

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     3180

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     3240

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     3300

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     3360

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     3420

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     3480

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     3540

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     3600

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     3660

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     3720

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     3780

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     3840

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     3900

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     3960

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     4020

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     4080

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     4140

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     4200

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     4260

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     4320

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     4380

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     4440

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     4500

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     4560

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     4620

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     4680

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     4740

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     4800

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     4860

ccacctgacg tcgatcgacg gatcgggaga tccgggacat gtacctccca ggggcccagg     4920

aagactacgg gaggctacac caacgtcaat cagaggggcc tgtgtagcta ccgataagcg     4980

gaccctcaag agggcattag caatagtgtt tataaggccc ccttgttaac cctaaacggg     5040

tagcatatgc ttcccgggta gtagtatata ctatccagac taaccctaat tcaatagcat     5100

atgttaccca acgggaagca tatgctatcg aattagggtt agtaaaaggg tcctaaggaa     5160

cagcgatatc tcccacccca tgagctgtca cggttttatt tacatggggt caggattcca     5220

cgagggtagt gaaccatttt agtcacaagg gcagtggctg aagatcaagg agcgggcagt     5280

gaactctcct gaatcttcgc ctgcttcttc attctccttc gtttagctaa tagaataact     5340

gctgagttgt gaacagtaag gtgtatgtga ggtgctcgaa aacaaggttt caggtgacgc     5400

ccccagaata aaatttggac ggggggttca gtggtggcat tgtgctatga caccaatata     5460

accctcacaa accccttggg caataaatac tagtgtagga atgaaacatt ctgaatatct     5520

ttaacaatag aaatccatgg ggtggggaca agccgtaaag actggatgtc catctcacac     5580

gaatttatgg ctatgggcaa cacataatcc tagtgcaata tgatactggg gttattaaga     5640

tgtgtcccag gcagggacca agacaggtga accatgttgt tacactctat ttgtaacaag     5700

gggaaagaga gtggacgccg acagcagcgg actccactgg ttgtctctaa cacccccgaa     5760

aattaaacgg ggctccacgc caatggggcc cataaacaaa gacaagtggc cactcttttt     5820

tttgaaattg tggagtgggg gcacgcgtca gcccccacac gccgccctgc ggttttggac     5880

tgtaaaataa gggtgtaata acttggctga ttgtaacccc gctaaccact gcggtcaaac     5940

cacttgccca caaaaccact aatggcaccc cggggaatac ctgcataagt aggtgggcgg     6000

gccaagatag gggcgcgatt gctgcgatct ggaggacaaa ttacacacac ttgcgcctga     6060

gcgccaagca cagggttgtt ggtcctcata ttcacgaggt cgctgagagc acggtgggct     6120

aatgttgcca tgggtagcat atactaccca aatatctgga tagcatatgc tatcctaatc     6180

tatatctggg tagcataggc tatcctaatc tatatctggg tagcatatgc tatcctaatc     6240

tatatctggg tagtatatgc tatcctaatt tatatctggg tagcataggc tatcctaatc     6300

tatatctggg tagcatatgc tatcctaatc tatatctggg tagtatatgc tatcctaatc     6360

tgtatccggg tagcatatgc tatcctaata gagattaggg tagtatatgc tatcctaatt     6420

tatatctggg tagcatatac tacccaaata tctggatagc atatgctatc ctaatctata     6480

tctgggtagc atatgctatc ctaatctata tctgggtagc ataggctatc ctaatctata     6540

tctgggtagc atatgctatc ctaatctata tctgggtagt atatgctatc ctaatttata     6600

tctgggtagc ataggctatc ctaatctata tctgggtagc atatgctatc ctaatctata     6660

tctgggtagt atatgctatc ctaatctgta tccgggtagc atatgctatc ctcatgcata     6720

tacagtcagc atatgatacc cagtagtaga gtgggagtgc tatcctttgc atatgccgcc     6780

acctcccaag ggggcgtgaa ttttcgctgc ttgtcctttt cctgcatgcg gatcttcaat     6840

a                                                                     6841


<210>  5
<211>  3429
<212>  DNA
<213>  Homo sapiens

<400>  5
ctgggcccgg gctggaagcc ggaagcgagc aaagtggagc cgactcgaac tccaccgcgg       60

aaaagaaagc ctcagaacgt tcgttcgctg cgtccccagc cggggccgag ccctccgcga      120

cgccagccgg gccatggggg ccgcacgcag cccgccgtcc gctgtcccgg ggcccctgct      180

ggggctgctc ctgctgctcc tgggcgtgct ggccccgggt ggcgcctccc tgcgactcct      240

ggaccaccgg gcgctggtct gctcccagcc ggggctaaac tgcacggtca agaatagtac      300

ctgcctggat gacagctgga ttcaccctcg aaacctgacc ccctcctccc caaaggacct      360

gcagatccag ctgcactttg cccacaccca acaaggagac ctgttccccg tggctcacat      420

cgaatggaca ctgcagacag acgccagcat cctgtacctc gagggtgcag agttatctgt      480

cctgcagctg aacaccaatg aacgtttgtg cgtcaggttt gagtttctgt ccaaactgag      540

gcatcaccac aggcggtggc gttttacctt cagccacttt gtggttgacc ctgaccagga      600

atatgaggtg accgttcacc acctgcccaa gcccatccct gatggggacc caaaccacca      660

gtccaagaat ttccttgtgc ctgactgtga gcacgccagg atgaaggtaa ccacgccatg      720

catgagctca ggcagcctgt gggaccccaa catcaccgtg gagaccctgg aggcccacca      780

gctgcgtgtg agcttcaccc tgtggaacga atctacccat taccagatcc tgctgaccag      840

ttttccgcac atggagaacc acagttgctt tgagcacatg caccacatac ctgcgcccag      900

accagaagag ttccaccagc gatccaacgt cacactcact ctacgcaacc ttaaagggtg      960

ctgtcgccac caagtgcaga tccagccctt cttcagcagc tgcctcaatg actgcctcag     1020

acactccgcg actgtttcct gcccagaaat gccagacact ccagaaccaa ttccggacta     1080

catgcccctg tgggtgtact ggttcatcac gggcatctcc atcctgctgg tgggctccgt     1140

catcctgctc atcgtctgca tgacctggag gctagctggg cctggaagtg aaaaatacag     1200

tgatgacacc aaatacaccg atggcctgcc tgcggctgac ctgatccccc caccgctgaa     1260

gcccaggaag gtctggatca tctactcagc cgaccacccc ctctacgtgg acgtggtcct     1320

gaaattcgcc cagttcctgc tcaccgcctg cggcacggaa gtggccctgg acctgctgga     1380

agagcaggcc atctcggagg caggagtcat gacctgggtg ggccgtcaga agcaggagat     1440

ggtggagagc aactctaaga tcatcgtcct gtgctcccgc ggcacgcgcg ccaagtggca     1500

ggcgctcctg ggccgggggg cgcctgtgcg gctgcgctgc gaccacggaa agcccgtggg     1560

ggacctgttc actgcagcca tgaacatgat cctcccggac ttcaagaggc cagcctgctt     1620

cggcacctac gtagtctgct acttcagcga ggtcagctgt gacggcgacg tccccgacct     1680

gttcggcgcg gcgccgcggt acccgctcat ggacaggttc gaggaggtgt acttccgcat     1740

ccaggacctg gagatgttcc agccgggccg catgcaccgc gtaggggagc tgtcggggga     1800

caactacctg cggagcccgg gcggcaggca gctccgcgcc gccctggaca ggttccggga     1860

ctggcaggtc cgctgtcccg actggttcga atgtgagaac ctctactcag cagatgacca     1920

ggatgccccg tccctggacg aagaggtgtt tgaggagcca ctgctgcctc cgggaaccgg     1980

catcgtgaag cgggcgcccc tggtgcgcga gcctggctcc caggcctgcc tggccataga     2040

cccgctggtc ggggaggaag gaggagcagc agtggcaaag ctggaacctc acctgcagcc     2100

ccggggtcag ccagcgccgc agcccctcca caccctggtg ctcgccgcag aggagggggc     2160

cctggtggcc gcggtggagc ctgggcccct ggctgacggt gccgcagtcc ggctggcact     2220

ggcgggggag ggcgaggcct gcccgctgct gggcagcccg ggcgctgggc gaaatagcgt     2280

cctcttcctc cccgtggacc ccgaggactc gccccttggc agcagcaccc ccatggcgtc     2340

tcctgacctc cttccagagg acgtgaggga gcacctcgaa ggcttgatgc tctcgctctt     2400

cgagcagagt ctgagctgcc aggcccaggg gggctgcagt agacccgcca tggtcctcac     2460

agacccacac acgccctacg aggaggagca gcggcagtca gtgcagtctg accagggcta     2520

catctccagg agctccccgc agccccccga gggactcacg gaaatggagg aagaggagga     2580

agaggagcag gacccaggga agccggccct gccactctct cccgaggacc tggagagcct     2640

gaggagcctc cagcggcagc tgcttttccg ccagctgcag aagaactcgg gctgggacac     2700

gatggggtca gagtcagagg ggcccagtgc atgagggcgg ctccccaggg accgcccaga     2760

tcccagcttt gagagaggag tgtgtgtgca cgtattcatc tgtgtgtaca tgtctgcatg     2820

tgtatatgtt cgtgtgtgaa atgtaggctt taaaatgtaa atgtctggat tttaatccca     2880

ggcatccctc ctaacttttc tttgtgcagc ggtctggtta tcgtctatcc ccaggggaat     2940

ccacacagcc cgctcccagg agctaatggt agagcgtcct tgaggctcca ttattcgttc     3000

attcagcatt tattgtgcac ctactatgtg gcgggcattt gggataccaa gataaattgc     3060

atgcggcatg gccccagcca tgaaggaact taaccgctag tgccgaggac acgttaaacg     3120

aacaggatgg gccgggcacg gtggctcacg cctgtaatcc cagcacactg ggaggccgag     3180

gcaggtggat cactctgagg tcaggagttt gagccagcct ggccaacatg gtgaaacccc     3240

atctccacta aaaatagaaa aattagccgg gcatggtgac acatgcctgt agtcctagct     3300

acttgggagg ctgaggcagg agaattgctt gaatctggga ggcagaggtt gcagtgagcc     3360

gagattgtgc cattgcactg cagcctggat gacagagcga gactctatct caaaaaaaaa     3420

aaaaaaaaa                                                             3429


<210>  6
<211>  7356
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NPL012271 - SEQ ID NO: 6


<220>
<221>  APP6-Avi tag
<222>  (1527)..(1595)
<223>  encoding APP6-Avi tag.

<400>  6
gtattagtca tcgctattac catggtgatg cggttttggc agtacaccaa tgggcgtgga       60

tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg      120

ttttggcacc aaaatcaacg ggactttcca aaatgtcgta ataaccccgc cccgttgacg      180

caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac      240

cgtcagatcg cctggagacg ccatccacgc tgttttgacc tccatagaag acaccgggac      300

cgatccagcc tccgcggccg ggaacggtgc attggaacgc ggattccccg tgccaagagt      360

gacgtaagta ccgcctatag agtctatagg cccaccccct tggcttcgtt agaacgcggc      420

tacaattaat acataacctt atgtatcata cacatacgat ttaggtgaca ctatagaata      480

acatccactt tgcctttctc tccacaggtg tccactccca ggtccaactg cacggaagct      540

tctgcaggtc gaccaattga gatctggtac ctcgatcaac aagtttgtac aaaaaagcag      600

gcttggccgc caccatgccc ctgctcctgc tgctgcccct gctgtgggcc ggagccctgg      660

ccctgcgact cctggaccac cgggcgctgg tctgctccca gccggggcta aactgcacgg      720

tcaagaatag tacctgcctg gatgacagct ggattcaccc tcgaaacctg accccctcct      780

ccccaaagga cctgcagatc cagctgcact ttgcccacac ccaacaagga gacctgttcc      840

ccgtggctca catcgaatgg acactgcaga cagacgccag catcctgtac ctcgagggtg      900

cagagttatc tgtcctgcag ctgaacacca atgaacgttt gtgcgtcagg tttgagtttc      960

tgtccaaact gaggcatcac cacaggcggt ggcgttttac cttcagccac tttgtggttg     1020

accctgacca ggaatatgag gtgaccgttc accacctgcc caagcccatc cctgatgggg     1080

acccaaacca ccagtccaag aatttccttg tgcctgactg tgagcacgcc aggatgaagg     1140

taaccacgcc atgcatgagc tcaggcagcc tgtgggaccc caacatcacc gtggagaccc     1200

tggaggccca ccagctgcgt gtgagcttca ccctgtggaa cgaatctacc cattaccaga     1260

tcctgctgac cagttttccg cacatggaga accacagttg ctttgagcac atgcaccaca     1320

tacctgcgcc cagaccagaa gagttccacc agcgatccaa cgtcacactc actctacgca     1380

accttaaagg gtgctgtcgc caccaagtgc agatccagcc cttcttcagc agctgcctca     1440

atgactgcct cagacactcc gcgactgttt cctgcccaga aatgccagac actccagaac     1500

caattccgga ctacatgccc ctgtgggaat tccgtcacga ctccggcggc ggcctgaacg     1560

atatctttga agcgcagaaa attgagtggc atgaataatg aacccagctt tcttgtacaa     1620

agtggttgat cgatggcggc cgctctagag ggcccgttta aacccgctga tcagcctcga     1680

ctgtgccttc tagttgccag ccatctgttg tttgcccctc ccccgtgcct tccttgaccc     1740

tggaaggtgc cactcccact gtcctttcct aataaaatga ggaaattgca tcgcattgtc     1800

tgagtaggtg tcattctatt ctggggggtg gggtggggca ggacagcaag ggggaggatt     1860

gggaagacaa tagcaggcat gctggggatg cggtgggctc tatggcttct gaggcggaaa     1920

gaaccagcta gctcgaggca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     1980

ccatagtccc gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt     2040

ctccgcccca tggctgacta atttttttta tttatgcaga ggccgaggcc gcctctgcct     2100

ctgagctatt ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc     2160

tcccgggagc ttgtatatcc attttcggat ctgatcagca cgtgttgaca attaatcatc     2220

ggcatagtat atcggcatag tataatacga caaggtgagg aactaaacca tggccaagtt     2280

gaccagtgcc gttccggtgc tcaccgcgcg cgacgtcgcc ggagcggtcg agttctggac     2340

cgaccggctc gggttctccc gggacttcgt ggaggacgac ttcgccggtg tggtccggga     2400

cgacgtgacc ctgttcatca gcgcggtcca ggaccaggtg gtgccggaca acaccctggc     2460

ctgggtgtgg gtgcgcggcc tggacgagct gtacgccgag tggtcggagg tcgtgtccac     2520

gaacttccgg gacgcctccg ggccggccat gaccgagatc ggcgagcagc cgtgggggcg     2580

ggagttcgcc ctgcgcgacc cggccggcaa ctgcgtgcac ttcgtggccg aggagcagga     2640

ctgacacgtg ctacgagatt tcgattccac cgccgccttc tatgaaaggt tgggcttcgg     2700

aatcgttttc cgggacgccg gctggatgat cctccagcgc ggggatctca tgctggagtt     2760

cttcgcccac cccaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     2820

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     2880

catcaatgta tcttatcatg tctgaatttt gcattaatga atcggccaac gcgcggggag     2940

aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     3000

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     3060

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     3120

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     3180

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     3240

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     3300

gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct gtaggtatct     3360

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     3420

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     3480

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     3540

tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat     3600

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     3660

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     3720

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     3780

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     3840

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     3900

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     3960

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     4020

ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat     4080

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     4140

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     4200

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     4260

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     4320

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     4380

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     4440

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     4500

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     4560

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag     4620

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac     4680

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc     4740

gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca     4800

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     4860

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc gatcgacgga tcgggagatc     4920

cgggacatgt acctcccagg ggcccaggaa gactacggga ggctacacca acgtcaatca     4980

gaggggcctg tgtagctacc gataagcgga ccctcaagag ggcattagca atagtgttta     5040

taaggccccc ttgttaaccc taaacgggta gcatatgctt cccgggtagt agtatatact     5100

atccagacta accctaattc aatagcatat gttacccaac gggaagcata tgctatcgaa     5160

ttagggttag taaaagggtc ctaaggaaca gcgatatctc ccaccccatg agctgtcacg     5220

gttttattta catggggtca ggattccacg agggtagtga accattttag tcacaagggc     5280

agtggctgaa gatcaaggag cgggcagtga actctcctga atcttcgcct gcttcttcat     5340

tctccttcgt ttagctaata gaataactgc tgagttgtga acagtaaggt gtatgtgagg     5400

tgctcgaaaa caaggtttca ggtgacgccc ccagaataaa atttggacgg ggggttcagt     5460

ggtggcattg tgctatgaca ccaatataac cctcacaaac cccttgggca ataaatacta     5520

gtgtaggaat gaaacattct gaatatcttt aacaatagaa atccatgggg tggggacaag     5580

ccgtaaagac tggatgtcca tctcacacga atttatggct atgggcaaca cataatccta     5640

gtgcaatatg atactggggt tattaagatg tgtcccaggc agggaccaag acaggtgaac     5700

catgttgtta cactctattt gtaacaaggg gaaagagagt ggacgccgac agcagcggac     5760

tccactggtt gtctctaaca cccccgaaaa ttaaacgggg ctccacgcca atggggccca     5820

taaacaaaga caagtggcca ctcttttttt tgaaattgtg gagtgggggc acgcgtcagc     5880

ccccacacgc cgccctgcgg ttttggactg taaaataagg gtgtaataac ttggctgatt     5940

gtaaccccgc taaccactgc ggtcaaacca cttgcccaca aaaccactaa tggcaccccg     6000

gggaatacct gcataagtag gtgggcgggc caagataggg gcgcgattgc tgcgatctgg     6060

aggacaaatt acacacactt gcgcctgagc gccaagcaca gggttgttgg tcctcatatt     6120

cacgaggtcg ctgagagcac ggtgggctaa tgttgccatg ggtagcatat actacccaaa     6180

tatctggata gcatatgcta tcctaatcta tatctgggta gcataggcta tcctaatcta     6240

tatctgggta gcatatgcta tcctaatcta tatctgggta gtatatgcta tcctaattta     6300

tatctgggta gcataggcta tcctaatcta tatctgggta gcatatgcta tcctaatcta     6360

tatctgggta gtatatgcta tcctaatctg tatccgggta gcatatgcta tcctaataga     6420

gattagggta gtatatgcta tcctaattta tatctgggta gcatatacta cccaaatatc     6480

tggatagcat atgctatcct aatctatatc tgggtagcat atgctatcct aatctatatc     6540

tgggtagcat aggctatcct aatctatatc tgggtagcat atgctatcct aatctatatc     6600

tgggtagtat atgctatcct aatttatatc tgggtagcat aggctatcct aatctatatc     6660

tgggtagcat atgctatcct aatctatatc tgggtagtat atgctatcct aatctgtatc     6720

cgggtagcat atgctatcct catgcatata cagtcagcat atgataccca gtagtagagt     6780

gggagtgcta tcctttgcat atgccgccac ctcccaaggg ggcgtgaatt ttcgctgctt     6840

gtccttttcc tgcatgcgga tcttcaatat tggccattag ccatattatt cattggttat     6900

atagcataaa tcaatattgg ctattggcca ttgcatacgt tgtatctata tcataatatg     6960

tacatttata ttggctcatg tccaatatga ccgccatgtt ggcattgatt attgactagt     7020

tattaatagt aatcaattac ggggtcatta gttcatagcc catatatgga gttccgcgtt     7080

acataactta cggtaaatgg cccgcctggc tgaccgccca acgacccccg cccattgacg     7140

tcaataatga cgtatgttcc catagtaacg ccaataggga ctttccattg acgtcaatgg     7200

gtggagtatt tacggtaaac tgcccacttg gcagtacatc aagtgtatca tatgccaagt     7260

ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct ggcattatgc ccagtacatg     7320

accttacggg actttcctac ttggcagtac atctac                               7356


<210>  7
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer 1 RS3766 - SEQ ID NO: 7

<400>  7
ccatgcccct gctcctgctg ctgcccctgc tgtgggccgg agccctggcc ctgcgactcc       60

tggaccaccg ggcgctgg                                                     78


<210>  8
<211>  74
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer 1 RS3768 - SEQ ID NO: 8

<400>  8
gcttcaaaga tatcgttcag gccgccgccg gagtcgtgac ggaattccca caggggcatg       60

tagtccggaa ttgg                                                         74


<210>  9
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer 2 RS3767 - SEQ ID NO: 9

<400>  9
ggggacaagt ttgtacaaaa aagcaggctt ggccgccacc atgcccctgc tcctgctgct       60

gcccctgctg g                                                            71


<210>  10
<211>  79
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer 2 RS3769 - SEQ ID NO: 10

<400>  10
ggggaccact ttgtacaaga aagctgggtt cattattcat gccactcaat tttctgcgct       60

tcaaagatat cgttcaggc                                                    79


<210>  11
<211>  219
<212>  PRT
<213>  Mus musculus

<400>  11

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Ile Tyr Phe Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  12
<211>  449
<212>  PRT
<213>  Mus musculus

<400>  12

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asn Asp Arg Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Phe Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Pro Met Asn Thr Trp Gly Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 
        115                 120                 125             


Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 
145                 150                 155                 160 


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 
            180                 185                 190         


Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 
        195                 200                 205             


Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 
    210                 215                 220                 


Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 
                245                 250                 255     


Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 
            260                 265                 270         


Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 
        275                 280                 285             


Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 
    290                 295                 300                 


Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 
305                 310                 315                 320 


Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 
                325                 330                 335     


Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 
            340                 345                 350         


Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 
        355                 360                 365             


Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 
    370                 375                 380                 


Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 
                405                 410                 415     


Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 
            420                 425                 430         


Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 
        435                 440                 445             


Lys 
    


