                         SEQUENCE LISTING

<110>  The Pirbright Institute
 
<120>  VACCINE

<130>  P120260PCT

<150>  GB 2016954.6
<151>  2020-10-26

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  1

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly 
        


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  2

Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val 
1               5                   10                  15      


Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe Leu 
            20                  25                  


<210>  3
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 heavy chain

<400>  3
gaggtccagc tgcaacaatc tggacctgag ctggtgaagc ctggggcttc agtgaagata       60

tcctgtaagg cttctggata cacgttcact gactactaca taaactgggt gaagcagagc      120

catggaaaga gccttgagtg gattggagat attaatccta ctaatggtga ttctacctac      180

agccagaagt tcaagggcaa ggccacattg actgtagaca agtcctccag cacagcctac      240

atggagctcc gcagcctgac atctgaggtc tctgcagtct attactgtgc aagagactat      300

gctatggact actggggtca aggaacctca gtcaccgtct cctca                      345


<210>  4
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 heavy chain amino acid sequence

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Asn Pro Thr Asn Gly Asp Ser Thr Tyr Ser Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Val Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 heavy chain amino acid CDR-H1

<400>  5

Asp Tyr Tyr Ile Asn 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 heavy chain amino acid CDR-H2

<400>  6

Asp Ile Asn Pro Thr Asn Gly Asp Ser Thr Tyr Ser Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 heavy chain amino acid CDR-H3

<400>  7

Asp Tyr Ala Met Asp Tyr 
1               5       


<210>  8
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 light chain nucleotide sequence

<400>  8
gacattgtga tgacccagtc tccatcctcc ctggctgtgt cagtcggaca gaaggtcact       60

atgagctgca cgtccagtca ggtcctttta catagtccca atcaaaagaa ctatttggcc      120

tggtaccagc agaaaccagg acagtctcct aaacttctgg tatactttgc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactcttacc      240

atcagcagtg tgcaggctga agacctggca gtttattact gtcagcaaca ttatagcact      300

ccgctcacgt tcggtgctgg gaccaagctg gagctgaaa                             339


<210>  9
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 light chain amino acid sequence

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Thr Ser Ser Gln Val Leu Leu His Ser 
            20                  25                  30          


Pro Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  10
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 light chain amino acid CDR-L1

<400>  10

Thr Ser Ser Gln Val Leu Leu His Ser Pro Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 light chain amino acid CDR-L2

<400>  11

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD83 antibody clone F890/GE8 light chain amino acid CDR-L3

<400>  12

Gln Gln His Tyr Ser Thr Pro Leu Thr 
1               5                   


<210>  13
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain nucleotide sequence

<400>  13
gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg       60

tcctgcaagg cttctggata cacattcact aactatgttc tgcactgggt gaagcagaag      120

cctgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg tactaagttc      180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca catcctccag cacagccttc      240

atggaactca gcagcctgac ctctgaggac tctgcggtct attactgtgc aagaggagat      300

aatctacggc cctactactt tgactactgg ggccaaggca ccactctcac agtctcctca      360


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain amino acid sequence

<400>  14

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Val Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Phe Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Phe 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Asn Leu Arg Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain amino acid CDR-H1

<400>  15

Asn Tyr Val Leu His 
1               5   


<210>  16
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain amino acid CDR-H2

<400>  16

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Phe Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain amino acid CDR-H3

<400>  17

Gly Asp Asn Leu Arg Pro Tyr Tyr Phe Asp Tyr 
1               5                   10      


<210>  18
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 light chain nucleotide sequence

<400>  18
caaattgttc tcacccattc tccagcaatc atgtctgcat ctccagggga gaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt ttcatgtact ggtaccagca gaagccagga      120

tcctcccccc gactcctgct ttatgacaca tccagcctgt cttctggagt ccctgttcgc      180

ttcagtggca gtggctctgg gacctcttac tctctcacaa tcagccgaat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtcgttacc caccgacgtt cggtggaggc      300

accaagctgg aaatcaaa                                                    318


<210>  19
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain amino acid sequence

<400>  19

Gln Ile Val Leu Thr His Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Phe Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Arg Leu Leu Leu Tyr 
        35                  40                  45              


Asp Thr Ser Ser Leu Ser Ser Gly Val Pro Val Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Arg Tyr Pro Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain amino acid CDR-L1

<400>  20

Ser Ala Ser Ser Ser Val Ser Phe Met Tyr 
1               5                   10  


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain amino acid CDR-L2

<400>  21

Asp Thr Ser Ser Leu Ser Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-CD11c antibody clone 8F2 heavy chain amino acid CDR-L3

<400>  22

Gln Gln Trp Ser Arg Tyr Pro Pro Thr 
1               5                   


<210>  23
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 heavy chain nucleotide 
       sequence

<400>  23
gaggtgcaac tggtggagtc tgggggagac ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatggca tgtcttgggt tcgccagact      120

ccagacaaga ggctggagtg ggtcgcaacc attagtagtg gtggtagtta cacctactat      180

ccagacagtg tgaaggggcg attcaccatt tccagagaca atgccaagaa catcctgtat      240

ctgcaaatga gcagtctgaa gtctgaagac acagccatgt attactgtgc aagactttca      300

acctgggact ggtacttcga tgtctggggc acagggacca cggtcaccgt ctcctca         357


<210>  24
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 heavy chain amino acid 
       sequence

<400>  24

Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Ser Thr Trp Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 heavy chain amino acid CDR-H1

<400>  25

Ser Tyr Gly Met Ser 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 heavy chain amino acid CDR-H2

<400>  26

Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys Gly Arg 
1               5                   10                  15      


Phe 
    


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 heavy chain amino acid CDR-H3

<400>  27

Leu Ser Thr Trp Asp Trp Tyr Phe Asp Val 
1               5                   10  


<210>  28
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 light chain nucleotide 
       sequence

<400>  28
gaaattgtgc tcacccagtc tccagcactc atggctgcat ctccagggga gaaggtcacc       60

atcacctgca gtgtcagctc aagtataagt tccggcaact ttcactggta ccagcagaag      120

tcaggaacct cccccaaact ctggatttat ggcacatcca acctggcttc tggagtccct      180

gttcgcttca gtggcagtgg atctgggacc tcttattctc tcacaatcag cagcatggag      240

gctgaagatg ctgccactta ttactgtcaa cagtggagta gttacccatt cacgttcggc      300

tcggggacaa agttggaaat aaaa                                             324


<210>  29
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 light chain amino acid 
       sequence

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Gly 
            20                  25                  30          


Asn Phe His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 amino acid CDR-L1

<400>  30

Ser Val Ser Ser Ser Ile Ser Ser Gly Asn Phe His 
1               5                   10          


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 amino acid CDR-L2

<400>  31

Gly Thr Ser Asn Leu Ala Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-DEC205 antibody clone F887/AD6 amino acid CDR-L3

<400>  32

Gln Gln Trp Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable linker

<400>  33

Leu Glu Ala Gly Cys Lys Asn Phe Phe Pro Arg Ser Phe Thr Ser Cys 
1               5                   10                  15      


Gly Ser Leu Glu 
            20  


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  34

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  35
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  35

Ser Gly Ser Gly Ser Gly Ser 
1               5           


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  36

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artififcial sequence

<400>  37

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  38

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10          


<210>  39
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  39

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  artificial sequence

<400>  40

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met 
    


<210>  41
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H9HA ectodomain

<400>  41

Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu Thr Val 
1               5                   10                  15      


Asp Thr Leu Thr Glu Thr Asn Val Pro Val Thr His Ala Lys Glu Leu 
            20                  25                  30          


Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Asn Leu Gly His 
        35                  40                  45              


Pro Leu Ile Leu Asp Thr Cys Thr Ile Glu Gly Leu Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ser Cys Asp Leu Leu Leu Gly Gly Arg Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Arg Pro Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn Val Glu 
                85                  90                  95      


Asn Leu Glu Glu Leu Arg Thr Leu Phe Ser Ser Ser Ser Ser Tyr Gln 
            100                 105                 110         


Arg Ile Gln Ile Phe Pro Asp Thr Ile Trp Asn Val Thr Tyr Thr Gly 
        115                 120                 125             


Thr Ser Lys Ser Cys Ser Asp Ser Phe Tyr Arg Asn Met Arg Trp Leu 
    130                 135                 140                 


Thr Gln Lys Ser Gly Leu Tyr Pro Val Gln Asp Ala Gln Tyr Thr Asn 
145                 150                 155                 160 


Asn Arg Gly Lys Asp Ile Leu Phe Val Trp Gly Ile His His Pro Pro 
                165                 170                 175     


Thr Asp Thr Ala Gln Thr Asn Leu Tyr Thr Arg Thr Asp Thr Thr Thr 
            180                 185                 190         


Ser Val Thr Thr Glu Asn Leu Asp Arg Thr Phe Lys Pro Val Ile Gly 
        195                 200                 205             


Pro Arg Pro Leu Val Asn Gly Leu Ile Gly Arg Ile Asn Tyr Tyr Trp 
    210                 215                 220                 


Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Pro Trp Tyr Gly His Val Leu Ser Gly Glu Ser His Gly 
                245                 250                 255     


Arg Ile Leu Lys Thr Asp Leu Asn Ser Gly Asn Cys Val Val Gln Cys 
            260                 265                 270         


Gln Thr Glu Lys Gly Gly Leu Asn Ser Thr Leu Pro Phe His Asn Ile 
        275                 280                 285             


Ser Lys Tyr Ala Phe Gly Asn Cys Pro Lys Tyr Ile Gly Val Lys Ser 
    290                 295                 300                 


Leu Lys Leu Ala Ile Gly Leu Arg Asn Val Pro Ala Arg Ser Ser Arg 
305                 310                 315                 320 


Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Pro Gly 
                325                 330                 335     


Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln Gly Val 
            340                 345                 350         


Gly Met Ala Ala Asp Arg Asp Ser Thr Gln Lys Ala Val Asp Lys Ile 
        355                 360                 365             


Thr Ser Lys Val Asn Asn Ile Val Asp Lys Met Asn Lys Gln Tyr Glu 
    370                 375                 380                 


Ile Ile Asp His Glu Phe Ser Glu Val Glu Thr Arg Leu Asn Met Ile 
385                 390                 395                 400 


Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu His Asp 
            420                 425                 430         


Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu Gly Ser 
        435                 440                 445             


Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His Lys Cys 
    450                 455                 460                 


Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn Arg Arg 
465                 470                 475                 480 


Lys Tyr Lys Glu Glu Ser Arg Leu Glu Arg Gln 
                485                 490     


<210>  42
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 heavy chain 
       nucleotide sequence

<400>  42
gaggttcagc tgcagcagtc tgtggcagag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa aacacctata tgcactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatggtaa tactaggtat      180

gccccgaagt tccagggcaa ggccactata actgcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccatct attactgtgc ccgttattac      300

ttcggtcctg actactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  43
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 heavy chain amino 
       acid sequence

<400>  43

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Tyr Phe Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 heavy chain amino 
       acid CDR-H1

<400>  44

Asn Thr Tyr Met His 
1               5   


<210>  45
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 heavy chain amino 
       acid CDR-H2 (SEQ ID NO: 45

<400>  45

Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 heavy chain amino 
       acid CDR-H3

<400>  46

Tyr Tyr Phe Gly Pro Asp Tyr 
1               5           


<210>  47
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 light chain 
       nucleotide sequence

<400>  47
gacatcctga tgacccaatc tccatcctcc atgtctgtat ctctgggaga cacagtcatc       60

atcacttgcc atgcaagtca gggcattagc agtaatatag ggtggttgca gcagaaacca      120

gggaaatcat ttaagggcct gatctatcat gcaaccaact tggaagatgg agttccatca      180

aggttcagtg gcggtggatc tggagcagat tattctctca ccatcagcag cctggaatct      240

gaagattttg cagactatta ctgtgtacag tatggtcagt ttccattcac gttcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  48
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 light chain amino 
       acid sequence

<400>  48

Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Thr Val Ile Ile Thr Cys His Ala Ser Gln Gly Ile Ser Ser Asn 
            20                  25                  30          


Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu Ile 
        35                  40                  45              


Tyr His Ala Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Gly Gln Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 light chain amino 
       acid CDR-L1

<400>  49

His Ala Ser Gln Gly Ile Ser Ser Asn Ile Gly 
1               5                   10      


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 light chain amino 
       acid CDR-L2

<400>  50

His Ala Thr Asn Leu Glu Asp 
1               5           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/IG10 light chain amino 
       acid CDR-L3

<400>  51

Val Gln Tyr Gly Gln Phe Pro Phe Thr 
1               5                   


<210>  52
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 heavy chain nucleotide
       sequence

<400>  52
gaggttcagc tgcagcagtc tgtggcagag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa aacacctata tgcactgggt gaagcagagg      120

cctgaacagg gcctggagtg gattggaagg attgatcctg cgaatggtaa tactagatat      180

gccccgaaat tccagggcaa ggccactata actgcagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgacgac actgccatct attactgtgg taggacagag      300

ttcaggaatg ctatggacta ctggggtcaa ggaacctcag tcaccgtctc ctca            354


<210>  53
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 heavy chain amino acid
       sequence

<400>  53

Glu Val Gln Leu Gln Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Asp Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Gly Arg Thr Glu Phe Arg Asn Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 heavy chain amino acid
       CDR-H1

<400>  54

Asn Thr Tyr Met His 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 heavy chain amino acid
       CDR-H2

<400>  55

Arg Ile Asp Pro Ala Asn Gly Asn Thr Arg Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 heavy chain amino acid
       CDR-H3

<400>  56

Thr Glu Phe Arg Asn Ala Met Asp Tyr 
1               5                   


<210>  57
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 light chain nucleotide
       sequence

<400>  57
gacatccaga tgactcagtc tccagcctcc ctatctccat ctgtgggaga aactgtcacc       60

atgacatgtc gagcaagtga gaatatttac agtaatttag catggtatca gcagaaacag      120

ggaaaatctc ctcagctcct ggtctatgct gcaacaaact tagcagatgg tgtgccatca      180

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag cctgcagcct      240

gaagattttg ggaattatta ctgtcaacat ttttataata ctccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  58
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 light chain amino acid
       sequence

<400>  58

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Pro Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Met Thr Cys Arg Ala Ser Glu Asn Ile Tyr Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Ala Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Tyr Asn Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 light chain amino acid
       CDR-L1

<400>  59

Arg Ala Ser Glu Asn Ile Tyr Ser Asn Leu Ala 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 light chain amino acid
       CDR-L2

<400>  60

Ala Ala Thr Asn Leu Ala Asp 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  anti-hemagglutinin antibody clone F955/HD8 light chain amino acid
       CDR-L3

<400>  61

Gln His Phe Tyr Asn Thr Pro Tyr Thr 
1               5                   


<210>  62
<211>  811
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIP signal-H9HA ectodomain-Foldon-LINKER-CD83 scFv-V5-His tag

<400>  62

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu 
            20                  25                  30          


Thr Val Asp Thr Leu Thr Glu Thr Asn Val Pro Val Thr His Ala Lys 
        35                  40                  45              


Glu Leu Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Asn Leu 
    50                  55                  60                  


Gly His Pro Leu Ile Leu Asp Thr Cys Thr Ile Glu Gly Leu Ile Tyr 
65                  70                  75                  80  


Gly Asn Pro Ser Cys Asp Leu Leu Leu Gly Gly Arg Glu Trp Ser Tyr 
                85                  90                  95      


Ile Val Glu Arg Pro Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn 
            100                 105                 110         


Val Glu Asn Leu Glu Glu Leu Arg Thr Leu Phe Ser Ser Ser Ser Ser 
        115                 120                 125             


Tyr Gln Arg Ile Gln Ile Phe Pro Asp Thr Ile Trp Asn Val Thr Tyr 
    130                 135                 140                 


Thr Gly Thr Ser Lys Ser Cys Ser Asp Ser Phe Tyr Arg Asn Met Arg 
145                 150                 155                 160 


Trp Leu Thr Gln Lys Ser Gly Leu Tyr Pro Val Gln Asp Ala Gln Tyr 
                165                 170                 175     


Thr Asn Asn Arg Gly Lys Asp Ile Leu Phe Val Trp Gly Ile His His 
            180                 185                 190         


Pro Pro Thr Asp Thr Ala Gln Thr Asn Leu Tyr Thr Arg Thr Asp Thr 
        195                 200                 205             


Thr Thr Ser Val Thr Thr Glu Asn Leu Asp Arg Thr Phe Lys Pro Val 
    210                 215                 220                 


Ile Gly Pro Arg Pro Leu Val Asn Gly Leu Ile Gly Arg Ile Asn Tyr 
225                 230                 235                 240 


Tyr Trp Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn 
                245                 250                 255     


Gly Asn Leu Ile Ala Pro Trp Tyr Gly His Val Leu Ser Gly Glu Ser 
            260                 265                 270         


His Gly Arg Ile Leu Lys Thr Asp Leu Asn Ser Gly Asn Cys Val Val 
        275                 280                 285             


Gln Cys Gln Thr Glu Lys Gly Gly Leu Asn Ser Thr Leu Pro Phe His 
    290                 295                 300                 


Asn Ile Ser Lys Tyr Ala Phe Gly Asn Cys Pro Lys Tyr Ile Gly Val 
305                 310                 315                 320 


Lys Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val Pro Ala Arg Ser 
                325                 330                 335     


Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
            340                 345                 350         


Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln 
        355                 360                 365             


Gly Val Gly Met Ala Ala Asp Arg Asp Ser Thr Gln Lys Ala Val Asp 
    370                 375                 380                 


Lys Ile Thr Ser Lys Val Asn Asn Ile Val Asp Lys Met Asn Lys Gln 
385                 390                 395                 400 


Tyr Glu Ile Ile Asp His Glu Phe Ser Glu Val Glu Thr Arg Leu Asn 
                405                 410                 415     


Met Ile Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr 
            420                 425                 430         


Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu 
        435                 440                 445             


His Asp Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu 
    450                 455                 460                 


Gly Ser Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His 
465                 470                 475                 480 


Lys Cys Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn 
                485                 490                 495     


Arg Arg Lys Tyr Lys Glu Glu Ser Arg Leu Glu Arg Gln Gly Ser Gly 
            500                 505                 510         


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
        515                 520                 525             


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly Asp 
    530                 535                 540                 


Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly Gln 
545                 550                 555                 560 


Lys Val Thr Met Ser Cys Thr Ser Ser Gln Val Leu Leu His Ser Pro 
                565                 570                 575     


Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
            580                 585                 590         


Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val Pro 
        595                 600                 605             


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    610                 615                 620                 


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His 
625                 630                 635                 640 


Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            660                 665                 670         


Gly Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val 
        675                 680                 685             


Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr 
    690                 695                 700                 


Phe Thr Asp Tyr Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser 
705                 710                 715                 720 


Leu Glu Trp Ile Gly Asp Ile Asn Pro Thr Asn Gly Asp Ser Thr Tyr 
                725                 730                 735     


Ser Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser 
            740                 745                 750         


Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Val Ser Ala 
        755                 760                 765             


Val Tyr Tyr Cys Ala Arg Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
    770                 775                 780                 


Thr Ser Val Thr Val Ser Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu 
785                 790                 795                 800 


Gly Leu Asp Ser Thr His His His His His His 
                805                 810     


<210>  63
<211>  809
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIP signal-H9HA ectodomain-Foldon-LINKER-CD11c scFv-V5-His tag

<400>  63

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu 
            20                  25                  30          


Thr Val Asp Thr Leu Thr Glu Thr Asn Val Pro Val Thr His Ala Lys 
        35                  40                  45              


Glu Leu Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Asn Leu 
    50                  55                  60                  


Gly His Pro Leu Ile Leu Asp Thr Cys Thr Ile Glu Gly Leu Ile Tyr 
65                  70                  75                  80  


Gly Asn Pro Ser Cys Asp Leu Leu Leu Gly Gly Arg Glu Trp Ser Tyr 
                85                  90                  95      


Ile Val Glu Arg Pro Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn 
            100                 105                 110         


Val Glu Asn Leu Glu Glu Leu Arg Thr Leu Phe Ser Ser Ser Ser Ser 
        115                 120                 125             


Tyr Gln Arg Ile Gln Ile Phe Pro Asp Thr Ile Trp Asn Val Thr Tyr 
    130                 135                 140                 


Thr Gly Thr Ser Lys Ser Cys Ser Asp Ser Phe Tyr Arg Asn Met Arg 
145                 150                 155                 160 


Trp Leu Thr Gln Lys Ser Gly Leu Tyr Pro Val Gln Asp Ala Gln Tyr 
                165                 170                 175     


Thr Asn Asn Arg Gly Lys Asp Ile Leu Phe Val Trp Gly Ile His His 
            180                 185                 190         


Pro Pro Thr Asp Thr Ala Gln Thr Asn Leu Tyr Thr Arg Thr Asp Thr 
        195                 200                 205             


Thr Thr Ser Val Thr Thr Glu Asn Leu Asp Arg Thr Phe Lys Pro Val 
    210                 215                 220                 


Ile Gly Pro Arg Pro Leu Val Asn Gly Leu Ile Gly Arg Ile Asn Tyr 
225                 230                 235                 240 


Tyr Trp Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn 
                245                 250                 255     


Gly Asn Leu Ile Ala Pro Trp Tyr Gly His Val Leu Ser Gly Glu Ser 
            260                 265                 270         


His Gly Arg Ile Leu Lys Thr Asp Leu Asn Ser Gly Asn Cys Val Val 
        275                 280                 285             


Gln Cys Gln Thr Glu Lys Gly Gly Leu Asn Ser Thr Leu Pro Phe His 
    290                 295                 300                 


Asn Ile Ser Lys Tyr Ala Phe Gly Asn Cys Pro Lys Tyr Ile Gly Val 
305                 310                 315                 320 


Lys Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val Pro Ala Arg Ser 
                325                 330                 335     


Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
            340                 345                 350         


Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln 
        355                 360                 365             


Gly Val Gly Met Ala Ala Asp Arg Asp Ser Thr Gln Lys Ala Val Asp 
    370                 375                 380                 


Lys Ile Thr Ser Lys Val Asn Asn Ile Val Asp Lys Met Asn Lys Gln 
385                 390                 395                 400 


Tyr Glu Ile Ile Asp His Glu Phe Ser Glu Val Glu Thr Arg Leu Asn 
                405                 410                 415     


Met Ile Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr 
            420                 425                 430         


Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu 
        435                 440                 445             


His Asp Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu 
    450                 455                 460                 


Gly Ser Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His 
465                 470                 475                 480 


Lys Cys Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn 
                485                 490                 495     


Arg Arg Lys Tyr Lys Glu Glu Ser Arg Leu Glu Arg Gln Gly Ser Gly 
            500                 505                 510         


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
        515                 520                 525             


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly Glu 
    530                 535                 540                 


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
545                 550                 555                 560 


Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr Val 
                565                 570                 575     


Leu His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile Gly 
            580                 585                 590         


Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Phe Asn Glu Lys Phe Lys 
        595                 600                 605             


Gly Lys Ala Thr Leu Thr Ser Asp Thr Ser Ser Ser Thr Ala Phe Met 
    610                 615                 620                 


Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Ala 
625                 630                 635                 640 


Arg Gly Asp Asn Leu Arg Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
                645                 650                 655     


Thr Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            660                 665                 670         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr 
        675                 680                 685             


His Ser Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met 
    690                 695                 700                 


Thr Cys Ser Ala Ser Ser Ser Val Ser Phe Met Tyr Trp Tyr Gln Gln 
705                 710                 715                 720 


Lys Pro Gly Ser Ser Pro Arg Leu Leu Leu Tyr Asp Thr Ser Ser Leu 
                725                 730                 735     


Ser Ser Gly Val Pro Val Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser 
            740                 745                 750         


Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr 
        755                 760                 765             


Tyr Cys Gln Gln Trp Ser Arg Tyr Pro Pro Thr Phe Gly Gly Gly Thr 
    770                 775                 780                 


Lys Leu Glu Ile Lys Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu 
785                 790                 795                 800 


Asp Ser Thr His His His His His His 
                805                 


<210>  64
<211>  810
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BIP signal-H9HA ectodomain-Foldon-LINKER-Dec205 scFv-V5-His tag

<400>  64

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu 
            20                  25                  30          


Thr Val Asp Thr Leu Thr Glu Thr Asn Val Pro Val Thr His Ala Lys 
        35                  40                  45              


Glu Leu Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Asn Leu 
    50                  55                  60                  


Gly His Pro Leu Ile Leu Asp Thr Cys Thr Ile Glu Gly Leu Ile Tyr 
65                  70                  75                  80  


Gly Asn Pro Ser Cys Asp Leu Leu Leu Gly Gly Arg Glu Trp Ser Tyr 
                85                  90                  95      


Ile Val Glu Arg Pro Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn 
            100                 105                 110         


Val Glu Asn Leu Glu Glu Leu Arg Thr Leu Phe Ser Ser Ser Ser Ser 
        115                 120                 125             


Tyr Gln Arg Ile Gln Ile Phe Pro Asp Thr Ile Trp Asn Val Thr Tyr 
    130                 135                 140                 


Thr Gly Thr Ser Lys Ser Cys Ser Asp Ser Phe Tyr Arg Asn Met Arg 
145                 150                 155                 160 


Trp Leu Thr Gln Lys Ser Gly Leu Tyr Pro Val Gln Asp Ala Gln Tyr 
                165                 170                 175     


Thr Asn Asn Arg Gly Lys Asp Ile Leu Phe Val Trp Gly Ile His His 
            180                 185                 190         


Pro Pro Thr Asp Thr Ala Gln Thr Asn Leu Tyr Thr Arg Thr Asp Thr 
        195                 200                 205             


Thr Thr Ser Val Thr Thr Glu Asn Leu Asp Arg Thr Phe Lys Pro Val 
    210                 215                 220                 


Ile Gly Pro Arg Pro Leu Val Asn Gly Leu Ile Gly Arg Ile Asn Tyr 
225                 230                 235                 240 


Tyr Trp Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn 
                245                 250                 255     


Gly Asn Leu Ile Ala Pro Trp Tyr Gly His Val Leu Ser Gly Glu Ser 
            260                 265                 270         


His Gly Arg Ile Leu Lys Thr Asp Leu Asn Ser Gly Asn Cys Val Val 
        275                 280                 285             


Gln Cys Gln Thr Glu Lys Gly Gly Leu Asn Ser Thr Leu Pro Phe His 
    290                 295                 300                 


Asn Ile Ser Lys Tyr Ala Phe Gly Asn Cys Pro Lys Tyr Ile Gly Val 
305                 310                 315                 320 


Lys Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val Pro Ala Arg Ser 
                325                 330                 335     


Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
            340                 345                 350         


Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln 
        355                 360                 365             


Gly Val Gly Met Ala Ala Asp Arg Asp Ser Thr Gln Lys Ala Val Asp 
    370                 375                 380                 


Lys Ile Thr Ser Lys Val Asn Asn Ile Val Asp Lys Met Asn Lys Gln 
385                 390                 395                 400 


Tyr Glu Ile Ile Asp His Glu Phe Ser Glu Val Glu Thr Arg Leu Asn 
                405                 410                 415     


Met Ile Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr 
            420                 425                 430         


Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu 
        435                 440                 445             


His Asp Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu 
    450                 455                 460                 


Gly Ser Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His 
465                 470                 475                 480 


Lys Cys Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn 
                485                 490                 495     


Arg Arg Lys Tyr Lys Glu Glu Ser Arg Leu Glu Arg Gln Gly Ser Gly 
            500                 505                 510         


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
        515                 520                 525             


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Ser Gly Ser Gly Glu 
    530                 535                 540                 


Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ala Ala Ser Pro Gly Glu 
545                 550                 555                 560 


Lys Val Thr Ile Thr Cys Ser Val Ser Ser Ser Ile Ser Ser Gly Asn 
                565                 570                 575     


Phe His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Leu Trp Ile 
            580                 585                 590         


Tyr Gly Thr Ser Asn Leu Ala Ser Gly Val Pro Val Arg Phe Ser Gly 
        595                 600                 605             


Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala 
    610                 615                 620                 


Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Tyr Pro Phe 
625                 630                 635                 640 


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
            660                 665                 670         


Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Ser 
        675                 680                 685             


Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Gly 
    690                 695                 700                 


Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
705                 710                 715                 720 


Thr Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
                725                 730                 735     


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ile Leu Tyr Leu 
            740                 745                 750         


Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
        755                 760                 765             


Arg Leu Ser Thr Trp Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly Thr 
    770                 775                 780                 


Thr Val Thr Val Ser Ser Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly 
785                 790                 795                 800 


Leu Asp Ser Thr His His His His His His 
                805                 810 


<210>  65
<211>  2444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  65
atgaagttat gcatattact ggccgtcgtg gcctttgttg gcctctcgct cgggataaga       60

tctgcatcgg ccaccagagc accaacagca ccgagaccgt ggataccctg accgagacca      120

acgtgccagt gacccacgcc aaggagctgc tgcacaccga gcacaacgga atgctgtgcg      180

ccaccaatct gggccacccc ctgatcctgg atacctgcac catcgagggc ctgatctacg      240

gcaaccccag ctgcgatctg ctgctgggag gacgcgagtg gtcctacatt gtggagcgcc      300

ccagcgccgt gaacggaacc tgctatccag gcaacgtgga gaacctggag gagctgcgca      360

ccctgttcag cagctcgagc agctaccagc gcatccagat cttccccgat accatctgga      420

acgtgaccta caccggcacc agcaagagct gcagcgatag cttctaccgc aacatgcgct      480

ggctgaccca gaagtccggc ctgtacccag tgcaggatgc ccagtacacc aacaatcgcg      540

gcaaggacat cctgttcgtg tggggcatcc accacccccc aaccgatacc gcccagacca      600

atctgtacac ccgcaccgat accaccacca gcgtgaccac cgagaatctg gatcgcacct      660

tcaagcccgt gatcggccca cgcccactcg tgaatggact gatcggccgc atcaactact      720

attggagcgt gctgaagccc ggccagaccc tgcgcgtgcg cagcaatgga aatctgatcg      780

ccccgtggta cggccacgtg ctgagcggag agagccacgg ccgcattctg aagaccgatc      840

tgaacagcgg caactgcgtg gtgcagtgcc agaccgagaa gggcggcctg aatagcaccc      900

tgcccttcca caacatctcg aagtacgcct tcggaaactg ccccaagtac atcggcgtga      960

agtccctgaa gctggccatc ggcctgcgca atgtgccagc ccgcagtagt cgcggactgt     1020

tcggagccat tgccggcttc attgagggcg gctggccagg actggtggcc ggatggtacg     1080

gattccagca cagcaacgat cagggcgtgg gaatggccgc cgatcgcgat agtacccaga     1140

aggccgtgga taagatcacc tccaaagtga acaacatcgt ggacaagatg aacaagcagt     1200

acgagatcat cgaccacgag ttcagcgagg tggagacccg cctgaacatg atcaacaaca     1260

agatcgacga ccagatccag gatgtgtggg cctacaacgc cgagctgctg gtgctgctgg     1320

agaaccagaa gaccctggac gagcacgatg ccaacgtgaa caatctgtat aacaaagtga     1380

agcgcgccct gggcagcaac gccatggagg atggaaaggg atgcttcgag ctgtaccaca     1440

agtgcgacga tcagtgcatg gagaccatcc gcaacggcac ctacaaccgc cgcaagtaca     1500

aggaggagag ccgcctggag cgccagggca gcggctacat cccagaggcc ccacgcgacg     1560

gacaggccta tgtgcgcaag gatggcgagt gggtgctgct gagcaccttc ctgggttctg     1620

gctctggtga gatcgtgctg acacagagcc cagccttgat ggctgctagc ccaggcgaga     1680

aagtgaccat tacctgcagc gtgtccagca gcatcagcag cggcaacttc cactggtatc     1740

agcagaagtc cggcacctcg ccgaagctgt ggatctacgg aacaagcaat ctggccagcg     1800

gagtgccagt gcgctttagt ggaagtggaa gcggcaccag ctacagcctg accatcagta     1860

gcatggaagc cgaggatgcc gccacctact attgccagca gtggtcgagc taccccttca     1920

ccttcggcag tggcaccaag ctggaaatca aaggcggagg cggaagtggt ggcggaggtt     1980

caggtggtgg tggatcaggc ggaggtggta gtgaagtgca gctggttgaa agcggcggag     2040

acctggttaa gccaggcgga agcctgaagc tgagttgcgc tgccagcgga ttcaccttca     2100

gctcctacgg catgagctgg gtccgacaga cacccgataa gcgcttggag tgggttgcca     2160

ccattagcag cggaggcagc tacacgtact accccgatag tgtgaaggga cgcttcacca     2220

tcagccgcga taacgccaag aacatcctgt acctgcagat gagcagcctg aagtccgagg     2280

acaccgccat gtattactgc gcccgtctga gcacctggga ttggtacttc gatgtgtggg     2340

gcaccggaac caccgtgaca gttagtagtg gttctggctc tggtggtaag cctatcccta     2400

accctctcct cggtctcgat tctacgcatc atcaccatca ccat                      2444


<210>  66
<211>  2432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  66
atgaagttat gcatattact ggccgtcgtg gcctttgttg gcctctcgct cgggataaga       60

tctgcatcgg ccaccagagc accaacagca ccgagaccgt ggataccctg accgagacca      120

acgtgccagt gacccacgcc aaggagctgc tgcacaccga gcacaacgga atgctgtgcg      180

ccaccaatct gggccacccc ctgatcctgg atacctgcac catcgagggc ctgatctacg      240

gcaaccccag ctgcgatctg ctgctgggag gacgcgagtg gtcctacatt gtggagcgcc      300

ccagcgccgt gaacggaacc tgctatccag gcaacgtgga gaacctggag gagctgcgca      360

ccctgttcag cagctcgagc agctaccagc gcatccagat cttccccgat accatctgga      420

acgtgaccta caccggcacc agcaagagct gcagcgatag cttctaccgc aacatgcgct      480

ggctgaccca gaagtccggc ctgtacccag tgcaggatgc ccagtacacc aacaatcgcg      540

gcaaggacat cctgttcgtg tggggcatcc accacccccc aaccgatacc gcccagacca      600

atctgtacac ccgcaccgat accaccacca gcgtgaccac cgagaatctg gatcgcacct      660

tcaagcccgt gatcggccca cgcccactcg tgaatggact gatcggccgc atcaactact      720

attggagcgt gctgaagccc ggccagaccc tgcgcgtgcg cagcaatgga aatctgatcg      780

ccccgtggta cggccacgtg ctgagcggag agagccacgg ccgcattctg aagaccgatc      840

tgaacagcgg caactgcgtg gtgcagtgcc agaccgagaa gggcggcctg aatagcaccc      900

tgcccttcca caacatctcg aagtacgcct tcggaaactg ccccaagtac atcggcgtga      960

agtccctgaa gctggccatc ggcctgcgca atgtgccagc ccgcagtagt cgcggactgt     1020

tcggagccat tgccggcttc attgagggcg gctggccagg actggtggcc ggatggtacg     1080

gattccagca cagcaacgat cagggcgtgg gaatggccgc cgatcgcgat agtacccaga     1140

aggccgtgga taagatcacc tccaaagtga acaacatcgt ggacaagatg aacaagcagt     1200

acgagatcat cgaccacgag ttcagcgagg tggagacccg cctgaacatg atcaacaaca     1260

agatcgacga ccagatccag gatgtgtggg cctacaacgc cgagctgctg gtgctgctgg     1320

agaaccagaa gaccctggac gagcacgatg ccaacgtgaa caatctgtat aacaaagtga     1380

agcgcgccct gggcagcaac gccatggagg atggaaaggg atgcttcgag ctgtaccaca     1440

agtgcgacga tcagtgcatg gagaccatcc gcaacggcac ctacaaccgc cgcaagtaca     1500

aggaggagag ccgcctggag cgccagggca gcggctacat cccagaggcc ccacgcgacg     1560

gacaggccta tgtgcgcaag gatggcgagt gggtgctgct gagcaccttc ctgggttctg     1620

gctctggtga tatcgtgatg acccagtcgc caagcagtct ggctgtgtcc gtgggacaga     1680

aagtgaccat gagctgcacc agcagccagg tgctgctgca cagccccaac cagaagaatt     1740

acctggcctg gtatcagcag aagcccggcc aaagtccgaa gctgctggtc tactttgcca     1800

gcacacgcga gagcggagtg ccagatcgtt ttaccggaag cggcagcggc accgatttca     1860

ccctgacaat tagtagcgtg caggccgagg atctggccgt gtattactgc cagcagcact     1920

acagcacccc gctgacattt ggcgccggaa cgaagctgga actgaaaggc ggaggtggta     1980

gtggtggcgg aggatcaggt ggtggtggtt ctggcggtgg tggaagtgaa gtgcaactgc     2040

agcagagcgg cccagagctg gtcaaaccag gtgccagcgt gaagatcagc tgcaaggcca     2100

gcggatacac cttcaccgat tactacatca actgggtcaa gcagagccac ggcaagagcc     2160

tggaatggat cggcgatatc aaccccacca acggcgatag cacctacagc cagaagttca     2220

agggcaaagc cacgctgacc gtggataaga gtagcagcac cgcctacatg gaactgcgca     2280

gcctgacaag cgaagtgtcc gccgtgtact attgcgcccg tgattacgcc atggattact     2340

ggggacaggg caccagtgtg accgttagta gtggtaagcc tatccctaac cctctcctcg     2400

gtctcgattc tacgcatcat caccatcacc at                                   2432


<210>  67
<211>  2426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  67
atgaagttat gcatattact ggccgtcgtg gcctttgttg gcctctcgct cgggataaga       60

tctgcatcgg ccaccagagc accaacagca ccgagaccgt ggataccctg accgagacca      120

acgtgccagt gacccacgcc aaggagctgc tgcacaccga gcacaacgga atgctgtgcg      180

ccaccaatct gggccacccc ctgatcctgg atacctgcac catcgagggc ctgatctacg      240

gcaaccccag ctgcgatctg ctgctgggag gacgcgagtg gtcctacatt gtggagcgcc      300

ccagcgccgt gaacggaacc tgctatccag gcaacgtgga gaacctggag gagctgcgca      360

ccctgttcag cagctcgagc agctaccagc gcatccagat cttccccgat accatctgga      420

acgtgaccta caccggcacc agcaagagct gcagcgatag cttctaccgc aacatgcgct      480

ggctgaccca gaagtccggc ctgtacccag tgcaggatgc ccagtacacc aacaatcgcg      540

gcaaggacat cctgttcgtg tggggcatcc accacccccc aaccgatacc gcccagacca      600

atctgtacac ccgcaccgat accaccacca gcgtgaccac cgagaatctg gatcgcacct      660

tcaagcccgt gatcggccca cgcccactcg tgaatggact gatcggccgc atcaactact      720

attggagcgt gctgaagccc ggccagaccc tgcgcgtgcg cagcaatgga aatctgatcg      780

ccccgtggta cggccacgtg ctgagcggag agagccacgg ccgcattctg aagaccgatc      840

tgaacagcgg caactgcgtg gtgcagtgcc agaccgagaa gggcggcctg aatagcaccc      900

tgcccttcca caacatctcg aagtacgcct tcggaaactg ccccaagtac atcggcgtga      960

agtccctgaa gctggccatc ggcctgcgca atgtgccagc ccgcagtagt cgcggactgt     1020

tcggagccat tgccggcttc attgagggcg gctggccagg actggtggcc ggatggtacg     1080

gattccagca cagcaacgat cagggcgtgg gaatggccgc cgatcgcgat agtacccaga     1140

aggccgtgga taagatcacc tccaaagtga acaacatcgt ggacaagatg aacaagcagt     1200

acgagatcat cgaccacgag ttcagcgagg tggagacccg cctgaacatg atcaacaaca     1260

agatcgacga ccagatccag gatgtgtggg cctacaacgc cgagctgctg gtgctgctgg     1320

agaaccagaa gaccctggac gagcacgatg ccaacgtgaa caatctgtat aacaaagtga     1380

agcgcgccct gggcagcaac gccatggagg atggaaaggg atgcttcgag ctgtaccaca     1440

agtgcgacga tcagtgcatg gagaccatcc gcaacggcac ctacaaccgc cgcaagtaca     1500

aggaggagag ccgcctggag cgccagggca gcggctacat cccagaggcc ccacgcgacg     1560

gacaggccta tgtgcgcaag gatggcgagt gggtgctgct gagcaccttc ctgggttctg     1620

gctctggtga agtgcaactg caacaaagcg gcccagagct ggttaagcca ggtgccagtg     1680

tgaagatgag ctgcaaggcc agcggctaca ccttcaccaa ctacgtgctg cactgggtca     1740

agcagaagcc cggccaaggc ctggaatgga tcggctacat caacccctac aacgatggca     1800

ccaagttcaa cgagaagttc aagggcaaag ccacgctgac cagcgatacc agtagcagca     1860

ccgccttcat ggaactgagc agcctgacct ccgaagatag cgccgtgtac tattgcgccc     1920

gtggcgataa tctgcgcccc tactacttcg attactgggg ccagggaacg accctgacag     1980

ttagttcagg tggcggaggt agcggaggtg gtggatcagg tggtggtgga agtggtggcg     2040

gtggatccca gattgtgctg acacacagcc ccgccatcat gagtgctagc ccaggcgaga     2100

aagtgaccat gacatgcagt gccagcagca gcgtgtcctt catgtattgg tatcagcaaa     2160

agccgggcag cagcccgcgt ctgctgctgt atgatacaag ctccctgagc agcggagtgc     2220

ccgtgcgttt tagtggaagc ggatccggaa ccagctactc cctgaccatc agtcgcatgg     2280

aagccgaaga tgccgccacg tactactgcc agcagtggtc ccgttatccg ccaacattcg     2340

gcggaggcac caagctggaa atcaagggta agcctatccc taaccctctc ctcggtctcg     2400

attctacgca tcatcaccat caccat                                          2426


<210>  68
<211>  522
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD33 SIGNAL-IG10 scFv-(Glycine4Serine)4 linker-CD83 scFv-Ctag

<400>  68

Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      


Met Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Met Ser Val Ser Leu 
            20                  25                  30          


Gly Asp Thr Val Ile Ile Thr Cys His Ala Ser Gln Gly Ile Ser Ser 
        35                  40                  45              


Asn Ile Gly Trp Leu Gln Gln Lys Pro Gly Lys Ser Phe Lys Gly Leu 
    50                  55                  60                  


Ile Tyr His Ala Thr Asn Leu Glu Asp Gly Val Pro Ser Arg Phe Ser 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Ala Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu 
                85                  90                  95      


Ser Glu Asp Phe Ala Asp Tyr Tyr Cys Val Gln Tyr Gly Gln Phe Pro 
            100                 105                 110         


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln 
    130                 135                 140                 


Gln Ser Val Ala Glu Leu Val Arg Pro Gly Ala Ser Val Lys Leu Ser 
145                 150                 155                 160 


Cys Thr Ala Ser Gly Phe Asn Ile Lys Asn Thr Tyr Met His Trp Val 
                165                 170                 175     


Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Arg Ile Asp Pro 
            180                 185                 190         


Ala Asn Gly Asn Thr Arg Tyr Ala Pro Lys Phe Gln Gly Lys Ala Thr 
        195                 200                 205             


Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser 
    210                 215                 220                 


Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Tyr Tyr Phe 
225                 230                 235                 240 


Gly Pro Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val 
        275                 280                 285             


Ser Val Gly Gln Lys Val Thr Met Ser Cys Thr Ser Ser Gln Val Leu 
    290                 295                 300                 


Leu His Ser Pro Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys 
305                 310                 315                 320 


Pro Gly Gln Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu 
                325                 330                 335     


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
            340                 345                 350         


Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr 
        355                 360                 365             


Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys 
    370                 375                 380                 


Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
                405                 410                 415     


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
            420                 425                 430         


Thr Asp Tyr Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu 
        435                 440                 445             


Glu Trp Ile Gly Asp Ile Asn Pro Thr Asn Gly Asp Ser Thr Tyr Ser 
    450                 455                 460                 


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
465                 470                 475                 480 


Thr Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Val Ser Ala Val 
                485                 490                 495     


Tyr Tyr Cys Ala Arg Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            500                 505                 510         


Ser Val Thr Val Ser Ser Glu Pro Glu Ala 
        515                 520         


<210>  69
<211>  1569
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  69
atgcccttgt tgctgctgct gccactgctg tgggccggag ccctggccat ggatgatatt       60

ctgatgactc aatcgccaag ctccatgagt gtctcgctcg gcgacacggt aataataact      120

tgtcacgcta gtcagggcat tagcagtaac ataggatggc tccagcaaaa acccggcaag      180

agctttaagg gtttgattta ccacgcaacg aacctggaag atggagtgcc gagccgattt      240

agtggcggag gcagcggtgc cgattacagc ttgacaatat cgagtctgga atcggaggac      300

tttgccgatt attattgtgt acagtacggt cagtttccat ttacgttcgg aagcggtacg      360

aagttggaga taaaaggcgg aggcggaagt ggcggcggag gaagcggagg cggaggatcc      420

gaggttcaac tgcaacaatc ggttgcagaa ttggtacggc caggagcaag tgtgaagctg      480

agctgcacgg cgagcggttt caacataaag aacacttaca tgcactgggt gaagcaacgg      540

ccagagcagg gcttggagtg gattggacgc attgatcccg ccaacggcaa cactaggtac      600

gcgccgaaat tccaaggtaa agctacgatc actgcagata catcgagtaa caccgcctac      660

ctccaactct cgagtctcac tagcgaggat acggccatct attactgcgc acggtattat      720

ttcggacctg attactgggg tcagggaacg actctgactg tatccagtgg cggaggcgga      780

agtggcggcg gaggaagcgg aggcggagga tccggcggag gcggcagtga tatcgtgatg      840

acccagtcgc caagcagtct ggctgtgtcc gtgggacaga aagtgaccat gagctgcacc      900

agcagccagg tgctgctgca cagccccaac cagaagaatt acctggcctg gtatcagcag      960

aagcccggcc aaagtccgaa gctgctggtc tactttgcca gcacacgcga gagcggagtg     1020

ccagatcgtt ttaccggaag cggcagcggc accgatttca ccctgacaat tagtagcgtg     1080

caggccgagg atctggccgt gtattactgc cagcagcact acagcacccc gctgacattt     1140

ggcgccggaa cgaagctgga actgaaaggc ggaggtggta gtggtggcgg aggatcaggt     1200

ggtggtggtt ctgaagtgca actgcagcag agcggcccag agctggtcaa accaggtgcc     1260

agcgtgaaga tcagctgcaa ggccagcgga tacaccttca ccgattacta catcaactgg     1320

gtcaagcaga gccacggcaa gagcctggaa tggatcggcg atatcaaccc caccaacggc     1380

gatagcacct acagccagaa gttcaagggc aaagccacgc tgaccgtgga taagagtagc     1440

agcaccgcct acatggaact gcgcagcctg acaagcgaag tgtccgccgt gtactattgc     1500

gcccgtgatt acgccatgga ttactgggga cagggcacca gtgtgaccgt tagtagtgag     1560

ccagaggct                                                             1569


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  70

Gly Phe Leu Gly 
1               


<210>  71
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  71

Ala Leu Ala Leu 
1               


<210>  72
<211>  2574
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  72
atgaagctgt gcatcctgct ggccgtggtg gcctttgtgg gattgagttt gggacgtagt       60

ccatggcccg gggatcagat ctgtattggc tatcacgcca ataacagcac cgaacaagtt      120

gacaccatta tggaaaagaa cgtaacagtc acgcatgccc aggacattct cgagaaaacc      180

cacaatggca aactctgtga cttgaacggc gtcaaacctc tcatactgaa agactgttcg      240

gtcgcgggct ggctcctcgg taatcctatg tgcgacgaat ttatccgcgt acctgagtgg      300

tcgtatattg ttgagcgggc aaacccggca aatgatctct gctatcctgg aagcctcaac      360

gactatgaag aactcaaaca cctcctctcg cgcataaatc acttcgaaaa aatactcatc      420

ataccaaaga gcagttggcc taaccacgag acatcgctcg gcgtttcggc agcctgtccc      480

tatcagggaa ctccatcgtt tttccgtaat gtagtatggc tcatcaaaaa gaatgacgcc      540

tatcctacaa ttaaaattag ctataataac accaatcgcg aagacctcct gattatgtgg      600

ggtattcatc actccaataa cgccgaagaa cagaccaact tgtacaaaaa ccccactacc      660

tatataagtg tgggtaccag tacactgaac caaaggctgg ttccaaagat agctactcgt      720

agccaggtta atggtcaacg gggacgtatg gacttctttt ggacaatttt gaaaccaaac      780

gacgcaatac attttgaaag caatggtaac tttatcgccc cagagtacgc ctataagatc      840

gtcaagaagg gagactcgac gataatgaag agtgaagtag aatacggcca ctgcaatacg      900

aaatgtcaaa cgccagtcgg tgccatcaac agctcgatgc cgttccataa catccatccg      960

ctgacgattg gagagtgccc gaaatacgta aagagcaata aattggtctt ggccactggc     1020

ctccgtaata gtccccaggg cgagacacgg ggtctgttcg gtgccatcgc tggcttcatt     1080

gagggaggtt ggcagggtat ggtggacgga tggtacggct atcatcatag taatgaacag     1140

ggtagtggtt acgcagcgga taaggagtcc acccagaagg ctatcgatgg agtgacaaac     1200

aaggtgaaca gtattattga taaaatgaac acccaatttg aagcagtggg acgagagttc     1260

aataatctcg aacggcgcat cgaaaacctg aataaaaaga tggaagacgg attcctcgac     1320

gtctggacct acaacgctga actgttggtg ctcatggaaa acgagcggac gctcgatttc     1380

cacgatagca atgttaagaa tctgtatgac aaagtccggc tccaattgcg agacaacgcc     1440

aaagaactgg gaaacggttg ttttgagttc tatcataaat gtgataacga gtgcatggaa     1500

agtgtccgaa atggaacata cgattaccca cagtattcgg aggaagctcg tttgaaaagg     1560

gaagaaatat ccggcgtaaa actcgaaagt atcggaacct atcaagcggc cgcaggcagc     1620

ggctacatcc cagaggcccc acgcgacgga caggcctatg tgcgcaagga tggcgagtgg     1680

gtgctgctga gcaccttcct gttaattaag aattcgcggc cgctcgaggg aagtggaagc     1740

ggagatatcg tgatgaccca gtcgccaagc agtctggctg tgtccgtggg acagaaagtg     1800

accatgagct gcaccagcag ccaggtgctg ctgcacagcc ccaaccagaa gaattacctg     1860

gcctggtatc agcagaagcc cggccaaagt ccgaagctgc tggtctactt tgccagcaca     1920

cgcgagagcg gagtgccaga tcgttttacc ggaagcggca gcggcaccga tttcaccctg     1980

acaattagta gcgtgcaggc cgaggatctg gccgtgtatt actgccagca gcactacagc     2040

accccgctga catttggcgc cggaacgaag ctggaactga aaggcggagg tggtagtggt     2100

ggcggaggat caggtggtgg tggttctggc ggtggtggaa gtgaagtgca actgcagcag     2160

agcggcccag agctggtcaa accaggtgcc agcgtgaaga tcagctgcaa ggccagcgga     2220

tacaccttca ccgattacta catcaactgg gtcaagcaga gccacggcaa gagcctggaa     2280

tggatcggcg atatcaaccc caccaacggc gatagcacct acagccagaa gttcaagggc     2340

aaagccacgc tgaccgtgga taagagtagc agcaccgcct acatggaact gcgcagcctg     2400

acaagcgaag tgtccgccgt gtactattgc gcccgtgatt acgccatgga ttactgggga     2460

cagggcacca gtgtgaccgt tagtagttct agagggccct tcgaaggtaa gcctatccct     2520

aaccctctcc tcggtctcga ttctacgcgt gaaggcggcg agccagaggc ttaa           2574


<210>  73
<211>  1788
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BIP-H5HA-Foldon

<400>  73
atgaagctgt gcatcctgct ggccgtggtg gcctttgtgg gattgagttt gggacgtagt       60

ccatggcccg gggatcagat ctgtattggc tatcacgcca ataacagcac cgaacaagtt      120

gacaccatta tggaaaagaa cgtaacagtc acgcatgccc aggacattct cgagaaaacc      180

cacaatggca aactctgtga cttgaacggc gtcaaacctc tcatactgaa agactgttcg      240

gtcgcgggct ggctcctcgg taatcctatg tgcgacgaat ttatccgcgt acctgagtgg      300

tcgtatattg ttgagcgggc aaacccggca aatgatctct gctatcctgg aagcctcaac      360

gactatgaag aactcaaaca cctcctctcg cgcataaatc acttcgaaaa aatactcatc      420

ataccaaaga gcagttggcc taaccacgag acatcgctcg gcgtttcggc agcctgtccc      480

tatcagggaa ctccatcgtt tttccgtaat gtagtatggc tcatcaaaaa gaatgacgcc      540

tatcctacaa ttaaaattag ctataataac accaatcgcg aagacctcct gattatgtgg      600

ggtattcatc actccaataa cgccgaagaa cagaccaact tgtacaaaaa ccccactacc      660

tatataagtg tgggtaccag tacactgaac caaaggctgg ttccaaagat agctactcgt      720

agccaggtta atggtcaacg gggacgtatg gacttctttt ggacaatttt gaaaccaaac      780

gacgcaatac attttgaaag caatggtaac tttatcgccc cagagtacgc ctataagatc      840

gtcaagaagg gagactcgac gataatgaag agtgaagtag aatacggcca ctgcaatacg      900

aaatgtcaaa cgccagtcgg tgccatcaac agctcgatgc cgttccataa catccatccg      960

ctgacgattg gagagtgccc gaaatacgta aagagcaata aattggtctt ggccactggc     1020

ctccgtaata gtccccaggg cgagacacgg ggtctgttcg gtgccatcgc tggcttcatt     1080

gagggaggtt ggcagggtat ggtggacgga tggtacggct atcatcatag taatgaacag     1140

ggtagtggtt acgcagcgga taaggagtcc acccagaagg ctatcgatgg agtgacaaac     1200

aaggtgaaca gtattattga taaaatgaac acccaatttg aagcagtggg acgagagttc     1260

aataatctcg aacggcgcat cgaaaacctg aataaaaaga tggaagacgg attcctcgac     1320

gtctggacct acaacgctga actgttggtg ctcatggaaa acgagcggac gctcgatttc     1380

cacgatagca atgttaagaa tctgtatgac aaagtccggc tccaattgcg agacaacgcc     1440

aaagaactgg gaaacggttg ttttgagttc tatcataaat gtgataacga gtgcatggaa     1500

agtgtccgaa atggaacata cgattaccca cagtattcgg aggaagctcg tttgaaaagg     1560

gaagaaatat ccggcgtaaa actcgaaagt atcggaacct atcaagcggc cgcaggcagc     1620

ggctacatcc cagaggcccc acgcgacgga caggcctatg tgcgcaagga tggcgagtgg     1680

gtgctgctga gcaccttcct gtctagaggg cccttcgaag gtaagcctat ccctaaccct     1740

ctcctcggtc tcgattctac gcgtgaaggc ggcgagccag aggcttaa                  1788


<210>  74
<211>  1632
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H9HA-Foldon

<400>  74
atggaggcta ttagtctgat gattattctg ctggtggtga caacctcaaa tgccgataaa       60

atttgtattg gacatcagtc tactaacagc acagagactg tggacaccct gacagaatcc      120

aacatccccg tgacccaggc aaaagagctg ctgcacacag aacacaacgg gatgctgtgc      180

gccaccaatc tgggcaggcc cctgatcctg gacacttgca ccgtggaggg cctgatctac      240

ggaaacccta gctgcgatct gctgctgggc ggaagagagt ggagctacat cgtggaaagg      300

ccctccgcag tgaatggaac atgctaccct gggaacgtgg aaaatctgga ggaactgcgg      360

atgctgttca gctccgccag ctcctaccag agaatccaga tttttcctga tgctatctgg      420

aacgtgacct acgacggaac aagcaaatcc tgcagcaact ccttctacag aaatatgagg      480

tggctgaccc agaagaacgg gaattaccca attcaggatg ctcagtacac aaacaatcgg      540

ggaaaggaca tcctgtttat ttgggggatc caccaccccc ctactgatac cacacagacc      600

aacctgtaca caagaactga cactaccaca agcgtgacta ccgagaatct ggatagaact      660

ttcaaacctc tgatcggccc aaggcccctg gtgaacggcc tgattggacg catcaattac      720

tactggagcg tgctgaagcc tggacagact ctgcgcgtgc ggtccaacgg caatctgatc      780

gccccatggt acggacacgt gctgagcgga gagtcccacg gaaggattct gaagaccgac      840

ctgaaatccg ggaactgcgt ggtgcagtgc cagactgaaa aagggggcct gaacagcacc      900

ctgccattcc acaatatctc caaatacgcc ttcggcacat gccccaagta catcggagtg      960

aagagcctga aactggctat tggcctgcgc aacgtgccag caaagtccaa tcgggggctg     1020

ttcggcgcaa ttgccgggtt tatcgaggga ggatggccag gcctggtggc tggatggtac     1080

gggttccagc acagcaacga tcagggagtg ggaatggcag ctgacagggg aagcacacag     1140

aaggcagtgg ataaaatcac ttccaaggtg aacaacatca tcgataagat gaacaggcag     1200

tacgagatca ttgaccacga attttccgag attgaaacac gcctgaatat gattaacaac     1260

aagatcgatg accagattca ggacgtgtgg gcttacaacg cagagctgct ggtgctgctg     1320

gaaaatcaga agactctgga tgagcacgac gccaacgtga acaatctgta caataaggtg     1380

aaaagagccc tggggagcaa cgctatggag gatgggaaag gctgctttga actgtaccac     1440

aagtgcgatg accagtgcat ggaaacaatc aggaacggca cttacaatag aaggaagtac     1500

acagaggaaa gccgcctgga gaggcaggga tccggataca ttcctgaagc accacgcgat     1560

ggacaggcct acgtgaggaa ggatggggag tgggtgctgc tgagtacatt tctgggggaa     1620

cctgaggcat aa                                                         1632


<210>  75
<211>  2382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  H9HA-Foldon-CD83scFv

<400>  75
atggaggcta ttagtctgat gattattctg ctggtggtga caacctcaaa tgccgataaa       60

atttgtattg gacatcagtc tactaacagc acagagactg tggacaccct gacagaatcc      120

aacatccccg tgacccaggc aaaagagctg ctgcacacag aacacaacgg gatgctgtgc      180

gccaccaatc tgggcaggcc cctgatcctg gacacttgca ccgtggaggg cctgatctac      240

ggaaacccta gctgcgatct gctgctgggc ggaagagagt ggagctacat cgtggaaagg      300

ccctccgcag tgaatggaac atgctaccct gggaacgtgg aaaatctgga ggaactgcgg      360

atgctgttca gctccgccag ctcctaccag agaatccaga tttttcctga tgctatctgg      420

aacgtgacct acgacggaac aagcaaatcc tgcagcaact ccttctacag aaatatgagg      480

tggctgaccc agaagaacgg gaattaccca attcaggatg ctcagtacac aaacaatcgg      540

ggaaaggaca tcctgtttat ttgggggatc caccaccccc ctactgatac cacacagacc      600

aacctgtaca caagaactga cactaccaca agcgtgacta ccgagaatct ggatagaact      660

ttcaaacctc tgatcggccc aaggcccctg gtgaacggcc tgattggacg catcaattac      720

tactggagcg tgctgaagcc tggacagact ctgcgcgtgc ggtccaacgg caatctgatc      780

gccccatggt acggacacgt gctgagcgga gagtcccacg gaaggattct gaagaccgac      840

ctgaaatccg ggaactgcgt ggtgcagtgc cagactgaaa aagggggcct gaacagcacc      900

ctgccattcc acaatatctc caaatacgcc ttcggcacat gccccaagta catcggagtg      960

aagagcctga aactggctat tggcctgcgc aacgtgccag caaagtccaa tcgggggctg     1020

ttcggcgcaa ttgccgggtt tatcgaggga ggatggccag gcctggtggc tggatggtac     1080

gggttccagc acagcaacga tcagggagtg ggaatggcag ctgacagggg aagcacacag     1140

aaggcagtgg ataaaatcac ttccaaggtg aacaacatca tcgataagat gaacaggcag     1200

tacgagatca ttgaccacga attttccgag attgaaacac gcctgaatat gattaacaac     1260

aagatcgatg accagattca ggacgtgtgg gcttacaacg cagagctgct ggtgctgctg     1320

gaaaatcaga agactctgga tgagcacgac gccaacgtga acaatctgta caataaggtg     1380

aaaagagccc tggggagcaa cgctatggag gatgggaaag gctgctttga actgtaccac     1440

aagtgcgatg accagtgcat ggaaacaatc aggaacggca cttacaatag aaggaagtac     1500

acagaggaaa gccgcctgga gaggcaggga tccggataca ttcctgaagc accacgcgat     1560

ggacaggcct acgtgaggaa ggatggggag tgggtgctgc tgagtacatt tctggggccc     1620

ggggatattg tgatgaccca gtctcctagt agcctggccg tgtccgtggg gcagaaagtg     1680

accatgtctt gtacctcctc tcaggtgctg ctgcactccc ctaaccagaa aaattacctg     1740

gcctggtacc agcagaaacc tggccagagc cctaagctgc tggtgtactt cgccagcact     1800

agagagtccg gcgtgccaga taggttcaca ggatccggga gcggcactga ctttaccctg     1860

acaatcagct ccgtgcaggc cgaggatctg gccgtgtact actgccagca gcactacagc     1920

acccccctga catttggagc agggacaaaa ctggaactga agggcggagg aggatccgga     1980

ggaggaggaa gcggaggagg agggtccggc ggaggaggaa gcgaggtgca gctgcagcag     2040

agcggaccag aactggtgaa acccggagca agcgtgaaaa tctcctgcaa ggccagcgga     2100

tacactttca ccgattacta cattaactgg gtgaaacagt cccacgggaa gagcctggaa     2160

tggatcggcg atattaaccc tactaatgga gactccacct acagccagaa gtttaaaggc     2220

aaggctacac tgactgtgga caagagctcc agcaccgcat acatggagct gagatccctg     2280

acaagcgaag tgtccgccgt gtactactgt gccagagatt atgctatgga ctattggggc     2340

caggggacaa gcgtgactgt gagttccgaa cctgaggcat aa                        2382


<210>  76
<211>  857
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  76

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Arg Ser Pro Trp Pro Gly Asp Gln Ile Cys Ile Gly Tyr His 
            20                  25                  30          


Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val 
        35                  40                  45              


Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Thr His Asn Gly Lys 
    50                  55                  60                  


Leu Cys Asp Leu Asn Gly Val Lys Pro Leu Ile Leu Lys Asp Cys Ser 
65                  70                  75                  80  


Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp Glu Phe Ile Arg 
                85                  90                  95      


Val Pro Glu Trp Ser Tyr Ile Val Glu Arg Ala Asn Pro Ala Asn Asp 
            100                 105                 110         


Leu Cys Tyr Pro Gly Ser Leu Asn Asp Tyr Glu Glu Leu Lys His Leu 
        115                 120                 125             


Leu Ser Arg Ile Asn His Phe Glu Lys Ile Leu Ile Ile Pro Lys Ser 
    130                 135                 140                 


Ser Trp Pro Asn His Glu Thr Ser Leu Gly Val Ser Ala Ala Cys Pro 
145                 150                 155                 160 


Tyr Gln Gly Thr Pro Ser Phe Phe Arg Asn Val Val Trp Leu Ile Lys 
                165                 170                 175     


Lys Asn Asp Ala Tyr Pro Thr Ile Lys Ile Ser Tyr Asn Asn Thr Asn 
            180                 185                 190         


Arg Glu Asp Leu Leu Ile Met Trp Gly Ile His His Ser Asn Asn Ala 
        195                 200                 205             


Glu Glu Gln Thr Asn Leu Tyr Lys Asn Pro Thr Thr Tyr Ile Ser Val 
    210                 215                 220                 


Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Lys Ile Ala Thr Arg 
225                 230                 235                 240 


Ser Gln Val Asn Gly Gln Arg Gly Arg Met Asp Phe Phe Trp Thr Ile 
                245                 250                 255     


Leu Lys Pro Asn Asp Ala Ile His Phe Glu Ser Asn Gly Asn Phe Ile 
            260                 265                 270         


Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys Gly Asp Ser Thr Ile 
        275                 280                 285             


Met Lys Ser Glu Val Glu Tyr Gly His Cys Asn Thr Lys Cys Gln Thr 
    290                 295                 300                 


Pro Val Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile His Pro 
305                 310                 315                 320 


Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Lys Leu Val 
                325                 330                 335     


Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Gly Glu Thr Arg Gly Leu 
            340                 345                 350         


Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val 
        355                 360                 365             


Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr 
    370                 375                 380                 


Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn 
385                 390                 395                 400 


Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val 
                405                 410                 415     


Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys 
            420                 425                 430         


Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu 
        435                 440                 445             


Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn 
    450                 455                 460                 


Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala 
465                 470                 475                 480 


Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn 
                485                 490                 495     


Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr 
            500                 505                 510         


Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu 
        515                 520                 525             


Glu Ser Ile Gly Thr Tyr Gln Ala Ala Ala Gly Ser Gly Tyr Ile Pro 
    530                 535                 540                 


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
545                 550                 555                 560 


Val Leu Leu Ser Thr Phe Leu Leu Ile Lys Asn Ser Arg Pro Leu Glu 
                565                 570                 575     


Gly Ser Gly Ser Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu 
            580                 585                 590         


Ala Val Ser Val Gly Gln Lys Val Thr Met Ser Cys Thr Ser Ser Gln 
        595                 600                 605             


Val Leu Leu His Ser Pro Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln 
    610                 615                 620                 


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr 
625                 630                 635                 640 


Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr 
                645                 650                 655     


Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val 
            660                 665                 670         


Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Leu Thr Phe Gly Ala Gly 
        675                 680                 685             


Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    690                 695                 700                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Gln Gln 
705                 710                 715                 720 


Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys 
                725                 730                 735     


Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Tyr Ile Asn Trp Val Lys 
            740                 745                 750         


Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly Asp Ile Asn Pro Thr 
        755                 760                 765             


Asn Gly Asp Ser Thr Tyr Ser Gln Lys Phe Lys Gly Lys Ala Thr Leu 
    770                 775                 780                 


Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu Leu Arg Ser Leu 
785                 790                 795                 800 


Thr Ser Glu Val Ser Ala Val Tyr Tyr Cys Ala Arg Asp Tyr Ala Met 
                805                 810                 815     


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ser Arg Gly 
            820                 825                 830         


Pro Phe Glu Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser 
        835                 840                 845             


Thr Arg Glu Gly Gly Glu Pro Glu Ala 
    850                 855         


<210>  77
<211>  581
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  77

Met Lys Leu Cys Ile Leu Leu Ala Val Val Ala Phe Val Gly Leu Ser 
1               5                   10                  15      


Leu Gly Arg Ser Pro Trp Pro Gly Asp Gln Ile Cys Ile Gly Tyr His 
            20                  25                  30          


Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val 
        35                  40                  45              


Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Thr His Asn Gly Lys 
    50                  55                  60                  


Leu Cys Asp Leu Asn Gly Val Lys Pro Leu Ile Leu Lys Asp Cys Ser 
65                  70                  75                  80  


Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp Glu Phe Ile Arg 
                85                  90                  95      


Val Pro Glu Trp Ser Tyr Ile Val Glu Arg Ala Asn Pro Ala Asn Asp 
            100                 105                 110         


Leu Cys Tyr Pro Gly Ser Leu Asn Asp Tyr Glu Glu Leu Lys His Leu 
        115                 120                 125             


Leu Ser Arg Ile Asn His Phe Glu Lys Ile Leu Ile Ile Pro Lys Ser 
    130                 135                 140                 


Ser Trp Pro Asn His Glu Thr Ser Leu Gly Val Ser Ala Ala Cys Pro 
145                 150                 155                 160 


Tyr Gln Gly Thr Pro Ser Phe Phe Arg Asn Val Val Trp Leu Ile Lys 
                165                 170                 175     


Lys Asn Asp Ala Tyr Pro Thr Ile Lys Ile Ser Tyr Asn Asn Thr Asn 
            180                 185                 190         


Arg Glu Asp Leu Leu Ile Met Trp Gly Ile His His Ser Asn Asn Ala 
        195                 200                 205             


Glu Glu Gln Thr Asn Leu Tyr Lys Asn Pro Thr Thr Tyr Ile Ser Val 
    210                 215                 220                 


Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Lys Ile Ala Thr Arg 
225                 230                 235                 240 


Ser Gln Val Asn Gly Gln Arg Gly Arg Met Asp Phe Phe Trp Thr Ile 
                245                 250                 255     


Leu Lys Pro Asn Asp Ala Ile His Phe Glu Ser Asn Gly Asn Phe Ile 
            260                 265                 270         


Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys Gly Asp Ser Thr Ile 
        275                 280                 285             


Met Lys Ser Glu Val Glu Tyr Gly His Cys Asn Thr Lys Cys Gln Thr 
    290                 295                 300                 


Pro Val Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile His Pro 
305                 310                 315                 320 


Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Lys Leu Val 
                325                 330                 335     


Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Gly Glu Thr Arg Gly Leu 
            340                 345                 350         


Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Gln Gly Met Val 
        355                 360                 365             


Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr 
    370                 375                 380                 


Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn 
385                 390                 395                 400 


Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val 
                405                 410                 415     


Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys 
            420                 425                 430         


Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu 
        435                 440                 445             


Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn 
    450                 455                 460                 


Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala 
465                 470                 475                 480 


Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn 
                485                 490                 495     


Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr 
            500                 505                 510         


Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu 
        515                 520                 525             


Glu Ser Ile Gly Thr Tyr Gln Ala Ala Ala Gly Ser Gly Tyr Ile Pro 
    530                 535                 540                 


Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp 
545                 550                 555                 560 


Val Leu Leu Ser Thr Phe Leu Leu Ile Lys Ile Lys Thr Arg Glu Gly 
                565                 570                 575     


Gly Glu Pro Glu Ala 
            580     


<210>  78
<211>  793
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  78

Met Glu Ala Ile Ser Leu Met Ile Ile Leu Leu Val Val Thr Thr Ser 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu 
            20                  25                  30          


Thr Val Asp Thr Leu Thr Glu Ser Asn Ile Pro Val Thr Gln Ala Lys 
        35                  40                  45              


Glu Leu Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Asn Leu 
    50                  55                  60                  


Gly Arg Pro Leu Ile Leu Asp Thr Cys Thr Val Glu Gly Leu Ile Tyr 
65                  70                  75                  80  


Gly Asn Pro Ser Cys Asp Leu Leu Leu Gly Gly Arg Glu Trp Ser Tyr 
                85                  90                  95      


Ile Val Glu Arg Pro Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn 
            100                 105                 110         


Val Glu Asn Leu Glu Glu Leu Arg Met Leu Phe Ser Ser Ala Ser Ser 
        115                 120                 125             


Tyr Gln Arg Ile Gln Ile Phe Pro Asp Ala Ile Trp Asn Val Thr Tyr 
    130                 135                 140                 


Asp Gly Thr Ser Lys Ser Cys Ser Asn Ser Phe Tyr Arg Asn Met Arg 
145                 150                 155                 160 


Trp Leu Thr Gln Lys Asn Gly Asn Tyr Pro Ile Gln Asp Ala Gln Tyr 
                165                 170                 175     


Thr Asn Asn Arg Gly Lys Asp Ile Leu Phe Ile Trp Gly Ile His His 
            180                 185                 190         


Pro Pro Thr Asp Thr Thr Gln Thr Asn Leu Tyr Thr Arg Thr Asp Thr 
        195                 200                 205             


Thr Thr Ser Val Thr Thr Glu Asn Leu Asp Arg Thr Phe Lys Pro Leu 
    210                 215                 220                 


Ile Gly Pro Arg Pro Leu Val Asn Gly Leu Ile Gly Arg Ile Asn Tyr 
225                 230                 235                 240 


Tyr Trp Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn 
                245                 250                 255     


Gly Asn Leu Ile Ala Pro Trp Tyr Gly His Val Leu Ser Gly Glu Ser 
            260                 265                 270         


His Gly Arg Ile Leu Lys Thr Asp Leu Lys Ser Gly Asn Cys Val Val 
        275                 280                 285             


Gln Cys Gln Thr Glu Lys Gly Gly Leu Asn Ser Thr Leu Pro Phe His 
    290                 295                 300                 


Asn Ile Ser Lys Tyr Ala Phe Gly Thr Cys Pro Lys Tyr Ile Gly Val 
305                 310                 315                 320 


Lys Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val Pro Ala Lys Ser 
                325                 330                 335     


Asn Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
            340                 345                 350         


Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln 
        355                 360                 365             


Gly Val Gly Met Ala Ala Asp Arg Gly Ser Thr Gln Lys Ala Val Asp 
    370                 375                 380                 


Lys Ile Thr Ser Lys Val Asn Asn Ile Ile Asp Lys Met Asn Arg Gln 
385                 390                 395                 400 


Tyr Glu Ile Ile Asp His Glu Phe Ser Glu Ile Glu Thr Arg Leu Asn 
                405                 410                 415     


Met Ile Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr 
            420                 425                 430         


Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu 
        435                 440                 445             


His Asp Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu 
    450                 455                 460                 


Gly Ser Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His 
465                 470                 475                 480 


Lys Cys Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn 
                485                 490                 495     


Arg Arg Lys Tyr Thr Glu Glu Ser Arg Leu Glu Arg Gln Gly Ser Gly 
            500                 505                 510         


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
        515                 520                 525             


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Pro Gly Asp Ile Val 
    530                 535                 540                 


Met Thr Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly Gln Lys Val 
545                 550                 555                 560 


Thr Met Ser Cys Thr Ser Ser Gln Val Leu Leu His Ser Pro Asn Gln 
                565                 570                 575     


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
            580                 585                 590         


Leu Leu Val Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
        595                 600                 605             


Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    610                 615                 620                 


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser 
625                 630                 635                 640 


Thr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Gly Gly 
                645                 650                 655     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            660                 665                 670         


Gly Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro 
        675                 680                 685             


Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
    690                 695                 700                 


Asp Tyr Tyr Ile Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu 
705                 710                 715                 720 


Trp Ile Gly Asp Ile Asn Pro Thr Asn Gly Asp Ser Thr Tyr Ser Gln 
                725                 730                 735     


Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr 
            740                 745                 750         


Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Val Ser Ala Val Tyr 
        755                 760                 765             


Tyr Cys Ala Arg Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
    770                 775                 780                 


Val Thr Val Ser Ser Glu Pro Glu Ala 
785                 790             


<210>  79
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  79

Met Glu Ala Ile Ser Leu Met Ile Ile Leu Leu Val Val Thr Thr Ser 
1               5                   10                  15      


Asn Ala Asp Lys Ile Cys Ile Gly His Gln Ser Thr Asn Ser Thr Glu 
            20                  25                  30          


Thr Val Asp Thr Leu Thr Glu Ser Asn Ile Pro Val Thr Gln Ala Lys 
        35                  40                  45              


Glu Leu Leu His Thr Glu His Asn Gly Met Leu Cys Ala Thr Asn Leu 
    50                  55                  60                  


Gly Arg Pro Leu Ile Leu Asp Thr Cys Thr Val Glu Gly Leu Ile Tyr 
65                  70                  75                  80  


Gly Asn Pro Ser Cys Asp Leu Leu Leu Gly Gly Arg Glu Trp Ser Tyr 
                85                  90                  95      


Ile Val Glu Arg Pro Ser Ala Val Asn Gly Thr Cys Tyr Pro Gly Asn 
            100                 105                 110         


Val Glu Asn Leu Glu Glu Leu Arg Met Leu Phe Ser Ser Ala Ser Ser 
        115                 120                 125             


Tyr Gln Arg Ile Gln Ile Phe Pro Asp Ala Ile Trp Asn Val Thr Tyr 
    130                 135                 140                 


Asp Gly Thr Ser Lys Ser Cys Ser Asn Ser Phe Tyr Arg Asn Met Arg 
145                 150                 155                 160 


Trp Leu Thr Gln Lys Asn Gly Asn Tyr Pro Ile Gln Asp Ala Gln Tyr 
                165                 170                 175     


Thr Asn Asn Arg Gly Lys Asp Ile Leu Phe Ile Trp Gly Ile His His 
            180                 185                 190         


Pro Pro Thr Asp Thr Thr Gln Thr Asn Leu Tyr Thr Arg Thr Asp Thr 
        195                 200                 205             


Thr Thr Ser Val Thr Thr Glu Asn Leu Asp Arg Thr Phe Lys Pro Leu 
    210                 215                 220                 


Ile Gly Pro Arg Pro Leu Val Asn Gly Leu Ile Gly Arg Ile Asn Tyr 
225                 230                 235                 240 


Tyr Trp Ser Val Leu Lys Pro Gly Gln Thr Leu Arg Val Arg Ser Asn 
                245                 250                 255     


Gly Asn Leu Ile Ala Pro Trp Tyr Gly His Val Leu Ser Gly Glu Ser 
            260                 265                 270         


His Gly Arg Ile Leu Lys Thr Asp Leu Lys Ser Gly Asn Cys Val Val 
        275                 280                 285             


Gln Cys Gln Thr Glu Lys Gly Gly Leu Asn Ser Thr Leu Pro Phe His 
    290                 295                 300                 


Asn Ile Ser Lys Tyr Ala Phe Gly Thr Cys Pro Lys Tyr Ile Gly Val 
305                 310                 315                 320 


Lys Ser Leu Lys Leu Ala Ile Gly Leu Arg Asn Val Pro Ala Lys Ser 
                325                 330                 335     


Asn Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
            340                 345                 350         


Pro Gly Leu Val Ala Gly Trp Tyr Gly Phe Gln His Ser Asn Asp Gln 
        355                 360                 365             


Gly Val Gly Met Ala Ala Asp Arg Gly Ser Thr Gln Lys Ala Val Asp 
    370                 375                 380                 


Lys Ile Thr Ser Lys Val Asn Asn Ile Ile Asp Lys Met Asn Arg Gln 
385                 390                 395                 400 


Tyr Glu Ile Ile Asp His Glu Phe Ser Glu Ile Glu Thr Arg Leu Asn 
                405                 410                 415     


Met Ile Asn Asn Lys Ile Asp Asp Gln Ile Gln Asp Val Trp Ala Tyr 
            420                 425                 430         


Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Gln Lys Thr Leu Asp Glu 
        435                 440                 445             


His Asp Ala Asn Val Asn Asn Leu Tyr Asn Lys Val Lys Arg Ala Leu 
    450                 455                 460                 


Gly Ser Asn Ala Met Glu Asp Gly Lys Gly Cys Phe Glu Leu Tyr His 
465                 470                 475                 480 


Lys Cys Asp Asp Gln Cys Met Glu Thr Ile Arg Asn Gly Thr Tyr Asn 
                485                 490                 495     


Arg Arg Lys Tyr Thr Glu Glu Ser Arg Leu Glu Arg Gln Gly Ser Gly 
            500                 505                 510         


Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
        515                 520                 525             


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly Glu Pro Glu Ala 
    530                 535                 540             


<210>  80
<211>  511
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H5N8 ectodomain

<400>  80

Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
1               5                   10                  15      


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
            20                  25                  30          


Leu Glu Lys Thr His Asn Gly Lys Leu Cys Asp Leu Asn Gly Val Lys 
        35                  40                  45              


Pro Leu Ile Leu Lys Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Met Cys Asp Glu Phe Ile Arg Val Pro Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Arg Ala Asn Pro Ala Asn Asp Leu Cys Tyr Pro Gly Ser Leu Asn 
                85                  90                  95      


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
            100                 105                 110         


Lys Ile Leu Ile Ile Pro Lys Ser Ser Trp Pro Asn His Glu Thr Ser 
        115                 120                 125             


Leu Gly Val Ser Ala Ala Cys Pro Tyr Gln Gly Thr Pro Ser Phe Phe 
    130                 135                 140                 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Asp Ala Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Ile Ser Tyr Asn Asn Thr Asn Arg Glu Asp Leu Leu Ile Met Trp 
                165                 170                 175     


Gly Ile His His Ser Asn Asn Ala Glu Glu Gln Thr Asn Leu Tyr Lys 
            180                 185                 190         


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Leu Val Pro Lys Ile Ala Thr Arg Ser Gln Val Asn Gly Gln Arg Gly 
    210                 215                 220                 


Arg Met Asp Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile His 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Val Glu Tyr Gly 
            260                 265                 270         


His Cys Asn Thr Lys Cys Gln Thr Pro Val Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asn Lys Leu Val Leu Ala Thr Gly Leu Arg Asn Ser 
305                 310                 315                 320 


Pro Gln Gly Glu Thr Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile 
                325                 330                 335     


Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His 
            340                 345                 350         


Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln 
        355                 360                 365             


Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys 
    370                 375                 380                 


Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu 
385                 390                 395                 400 


Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp 
                405                 410                 415     


Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg 
            420                 425                 430         


Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val 
        435                 440                 445             


Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe 
    450                 455                 460                 


Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg Asn 
465                 470                 475                 480 


Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg 
                485                 490                 495     


Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln 
            500                 505                 510     


