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<110>  OXFORD VACMEDIX UK LIMITED
 
<120>  CORONAVIRUS POLYPEPTIDES

<130>  1414-1004

<150>  GB2017118.7
<151>  2020-10-28

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  1

Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
1               5                   10                  15      


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
            20                  25                  30  


<210>  2
<211>  30
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  2

Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
1               5                   10                  15      


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
            20                  25                  30  


<210>  3
<211>  30
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  3

Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
1               5                   10                  15      


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  4

Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
1               5                   10                  15      


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  5

Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu 
1               5                   10                  15      


Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  6

Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
1               5                   10                  15      


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
            20                  25                  30  


<210>  7
<211>  30
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  7

Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
1               5                   10                  15      


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly 
            20                  25                  30  


<210>  8
<211>  30
<212>  PRT
<213>  Coravirus SARS-CoV-2

<400>  8

Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
1               5                   10                  15      


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
            20                  25                  30  


<210>  9
<211>  31
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  9

Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
1               5                   10                  15      


Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
            20                  25                  30      


<210>  10
<211>  36
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  10

Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile 
1               5                   10                  15      


Asp Arg Leu Asn Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu 
            20                  25                  30          


Gln Glu Leu Gly 
        35      


<210>  11
<211>  31
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  11

Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu 
1               5                   10                  15      


Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp 
            20                  25                  30      


<210>  12
<211>  31
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  12

Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro 
1               5                   10                  15      


Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val 
            20                  25                  30      


<210>  13
<211>  1273
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  13

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  14
<211>  673
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  14

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
            20                  25                  30          


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
        35                  40                  45              


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
    50                  55                  60                  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
                85                  90                  95      


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
            100                 105                 110         


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
        115                 120                 125             


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
145                 150                 155                 160 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
                165                 170                 175     


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
            180                 185                 190         


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
        195                 200                 205             


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
    210                 215                 220                 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
225                 230                 235                 240 


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
                245                 250                 255     


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
        275                 280                 285             


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
    290                 295                 300                 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
                325                 330                 335     


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            340                 345                 350         


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        355                 360                 365             


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    370                 375                 380                 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                405                 410                 415     


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            420                 425                 430         


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        435                 440                 445             


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    450                 455                 460                 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
465                 470                 475                 480 


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                485                 490                 495     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            500                 505                 510         


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
        515                 520                 525             


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
    530                 535                 540                 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
545                 550                 555                 560 


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
                565                 570                 575     


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
            580                 585                 590         


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
        595                 600                 605             


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
    610                 615                 620                 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
625                 630                 635                 640 


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
                645                 650                 655     


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
            660                 665                 670         


Arg 
    


<210>  15
<211>  181
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  15

Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
1               5                   10                  15      


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            20                  25                  30          


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        35                  40                  45              


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    50                  55                  60                  


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
65                  70                  75                  80  


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                85                  90                  95      


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            100                 105                 110         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        115                 120                 125             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    130                 135                 140                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
145                 150                 155                 160 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                165                 170                 175     


Val Leu Ser Phe Glu 
            180     


<210>  16
<211>  211
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  16

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys 
    210     


<210>  17
<211>  69
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  17

Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr 
1               5                   10                  15      


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
            20                  25                  30          


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly 
        35                  40                  45              


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
    50                  55                  60                  


Gly Val Gly Tyr Gln 
65                  


<210>  18
<211>  588
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  18

Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
1               5                   10                  15      


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
            20                  25                  30          


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
        35                  40                  45              


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
    50                  55                  60                  


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
65                  70                  75                  80  


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
                85                  90                  95      


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
            100                 105                 110         


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
        115                 120                 125             


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
    130                 135                 140                 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
145                 150                 155                 160 


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
                165                 170                 175     


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
            180                 185                 190         


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
        195                 200                 205             


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
    210                 215                 220                 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
225                 230                 235                 240 


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
                245                 250                 255     


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
            260                 265                 270         


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
        275                 280                 285             


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala 
    290                 295                 300                 


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
305                 310                 315                 320 


Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
                325                 330                 335     


Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser 
            340                 345                 350         


Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 
        355                 360                 365             


Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro 
    370                 375                 380                 


Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly 
385                 390                 395                 400 


Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 
                405                 410                 415     


Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr 
            420                 425                 430         


Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val 
        435                 440                 445             


Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys 
    450                 455                 460                 


Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp 
465                 470                 475                 480 


Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys 
                485                 490                 495     


Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu 
            500                 505                 510         


Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro 
        515                 520                 525             


Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val Met 
    530                 535                 540                 


Val Thr Ile Met Leu Cys Cys Met Thr Ser Cys Cys Ser Cys Leu Lys 
545                 550                 555                 560 


Gly Cys Cys Ser Cys Gly Ser Cys Cys Lys Phe Asp Glu Asp Asp Ser 
                565                 570                 575     


Glu Pro Val Leu Lys Gly Val Lys Leu His Tyr Thr 
            580                 585             


<210>  19
<211>  53
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  19

His Thr Ser Pro Asp Val Asp Leu Gly Asp Ile Ser Gly Ile Asn Ala 
1               5                   10                  15      


Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val Ala 
            20                  25                  30          


Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr 
        35                  40                  45              


Glu Gln Tyr Ile Lys 
    50              


<210>  20
<211>  421
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A polypeptide comprising 12 sequences from a SARS-CoV-2 S protein
       each interspersed with a LRMK cleavage site for cathepsin S, and 
       with a N terminal His6 tag


<220>
<221>  N terminal His6 tag
<222>  (2)..(7)

<400>  20

Met His His His His His His Ser Val Leu Tyr Asn Ser Ala Ser Phe 
1               5                   10                  15      


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
            20                  25                  30          


Cys Phe Thr Asn Val Leu Arg Met Lys Gly Val Ser Pro Thr Lys Leu 
        35                  40                  45              


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
    50                  55                  60                  


Gly Asp Glu Val Arg Gln Ile Leu Arg Met Lys Tyr Ala Asp Ser Phe 
65                  70                  75                  80  


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                85                  90                  95      


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Leu Arg Met Lys Ala Pro Gly 
            100                 105                 110         


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
        115                 120                 125             


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Arg Met Lys Pro 
    130                 135                 140                 


Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp 
145                 150                 155                 160 


Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Leu Arg Met 
                165                 170                 175     


Lys Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
            180                 185                 190         


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Leu 
        195                 200                 205             


Arg Met Lys Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
    210                 215                 220                 


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
225                 230                 235                 240 


Gly Leu Arg Met Lys Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
                245                 250                 255     


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
            260                 265                 270         


Gln Pro Thr Leu Arg Met Lys Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
        275                 280                 285             


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
    290                 295                 300                 


Val Val Leu Ser Phe Glu Leu Arg Met Lys Asp Ile Ser Gly Ile Asn 
305                 310                 315                 320 


Ala Ser Val Val Asn Ile Gln Lys Glu Ile Asp Arg Leu Asn Glu Val 
                325                 330                 335     


Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Leu 
            340                 345                 350         


Arg Met Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn 
        355                 360                 365             


Glu Ser Leu Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile 
    370                 375                 380                 


Lys Trp Leu Arg Met Lys Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu 
385                 390                 395                 400 


Gln Tyr Ile Lys Trp Pro Trp Tyr Ile Trp Leu Gly Phe Ile Ala Gly 
                405                 410                 415     


Leu Ile Ala Ile Val 
            420     


<210>  21
<211>  414
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A polypeptide comprising 12 sequences from a SARS-CoV-2 S 
       protein, each interspersed with a LRMK cleavage site for 
       cathepsin S

<400>  21

Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
1               5                   10                  15      


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Leu Arg 
            20                  25                  30          


Met Lys Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn 
        35                  40                  45              


Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile 
    50                  55                  60                  


Leu Arg Met Lys Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
65                  70                  75                  80  


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
                85                  90                  95      


Lys Leu Leu Arg Met Lys Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
            100                 105                 110         


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
        115                 120                 125             


Asn Ser Asn Asn Leu Arg Met Lys Pro Asp Asp Phe Thr Gly Cys Val 
    130                 135                 140                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
145                 150                 155                 160 


Asn Tyr Leu Tyr Arg Leu Leu Arg Met Lys Leu Asp Ser Lys Val Gly 
                165                 170                 175     


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
            180                 185                 190         


Pro Phe Glu Arg Asp Ile Ser Thr Leu Arg Met Lys Phe Arg Lys Ser 
        195                 200                 205             


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
    210                 215                 220                 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Leu Arg Met Lys Glu Ile 
225                 230                 235                 240 


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
                245                 250                 255     


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Leu Arg Met Lys 
            260                 265                 270         


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
        275                 280                 285             


Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu 
    290                 295                 300                 


Arg Met Lys Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln 
305                 310                 315                 320 


Lys Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser 
                325                 330                 335     


Leu Ile Asp Leu Gln Glu Leu Gly Leu Arg Met Lys Glu Ile Asp Arg 
            340                 345                 350         


Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp Leu Gln 
        355                 360                 365             


Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Leu Arg Met Lys Ile 
    370                 375                 380                 


Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Trp 
385                 390                 395                 400 


Tyr Ile Trp Leu Gly Phe Ile Ala Gly Leu Ile Ala Ile Val 
                405                 410                 


<210>  22
<211>  1278
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A DNA sequence codon-optimised for E.coli expression encoding a 
       polypeptide comprising 12 peptide fragments having sequences 
       derived from a SARS-CoV-2 S protein and comprising a LRMK 
       cleavage site for cathepsin S between each peptide fragment

<400>  22
catatgcatc accaccatca tcatagcgtc ctgtacaaca gcgcgagctt ttccaccttc       60

aaatgctacg gcgttagtcc gaccaaactg aacgatctgt gcttcaccaa cgtcctgcgt      120

atgaaaggcg ttagtccgac caaactgaac gatctgtgct tcaccaacgt ctacgcagat      180

agcttcgtaa ttcgcggcga cgaagttcgt caaatcctgc gcatgaaata cgccgatagc      240

ttcgtaattc gcggcgacga agttcgtcaa attgcaccgg gtcaaaccgg taaaattgcg      300

gattacaact acaaactgct gcgcatgaaa gcaccgggtc agaccggcaa aattgcggat      360

tacaactaca aactgccgga cgatttcacc ggttgcgtta ttgcctggaa cagcaacaac      420

ctgcgtatga aaccggacga tttcaccggt tgcgttattg cctggaacag caacaacctg      480

gatagcaaag tcggcggcaa ctacaactac ctgtatcgtc tgctgcgcat gaaactggat      540

agcaaagtgg gcggcaacta taactacctg tatcgtctgt tccgcaaaag caacctgaaa      600

ccgttcgaac gcgatatttc caccctgcgc atgaaattcc gcaaaagcaa cctgaaaccg      660

ttcgagcgcg atatcagcac cgaaatttat caggccggtt ctaccccgtg taacggcgtt      720

gaaggtctgc gcatgaaaga aatctaccag gcaggttcta ccccgtgtaa cggcgttgaa      780

ggtttcaact gctactttcc gctgcagagt tacggttttc agccgaccct gcgcatgaaa      840

ttcaactgct actttccgct gcagagctac ggttttcaac cgaccaacgg cgtaggttat      900

caaccgtatc gcgttgtcgt tctgagcttc gaactgcgca tgaaagacat cagcggtatt      960

aacgcgagcg tcgtcaacat ccagaaagag atcgaccgtc tgaacgaagt cgcgaaaaac     1020

ctgaacgaga gcctgattga tctgcaagaa ctgggtctgc gcatgaaaga aatcgaccgt     1080

ctgaacgaag tcgcgaaaaa cctgaacgaa agcctgatcg atctgcagga actgggcaaa     1140

tacgagcagt acatcaaatg gctgcgcatg aaaatcgatc tgcaggaact gggcaaatac     1200

gagcagtaca tcaaatggcc gtggtacatc tggctgggtt ttattgccgg tctgatcgcg     1260

attgtgtaat gaaagctt                                                   1278


<210>  23
<211>  17
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  23

Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
1               5                   10                  15      


Leu 
    


<210>  24
<211>  7
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  24

Gly Val Ser Pro Thr Lys Leu 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  25

Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
1               5                   10  


<210>  26
<211>  8
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  26

Pro Asp Asp Phe Thr Gly Cys Val 
1               5               


<210>  27
<211>  16
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  27

Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
1               5                   10                  15      


<210>  28
<211>  30
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  28

Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
1               5                   10                  15      


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
            20                  25                  30  


<210>  29
<211>  19
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  29

Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
1               5                   10                  15      


Ile Tyr Gln 
            


<210>  30
<211>  7
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  30

Ser Tyr Gly Phe Gln Pro Thr 
1               5           


<210>  31
<211>  15
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  31

Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
1               5                   10                  15  


<210>  32
<211>  20
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  32

Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile 
1               5                   10                  15      


Asp Arg Leu Asn 
            20  


<210>  33
<211>  6
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  33

Ile Asp Leu Gln Glu Leu 
1               5       


<210>  34
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  34

Leu Arg Met Lys 
1               


<210>  35
<211>  79
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  35

Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
1               5                   10                  15      


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
            20                  25                  30          


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
        35                  40                  45              


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
    50                  55                  60                  


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
65                  70                  75                  


<210>  36
<211>  69
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A receptor binding motif based on the Wuhan L strain of 
       SARS-CoV-2 but comprising E484K, N501Y, and L452R mutations as 
       found in Variants of Concern

<400>  36

Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr 
1               5                   10                  15      


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
            20                  25                  30          


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly 
        35                  40                  45              


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr 
    50                  55                  60                  


Gly Val Gly Tyr Gln 
65                  


<210>  37
<211>  9
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  37

Leu Thr Asp Glu Met Ile Ala Gln Tyr 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Coronavirus SARS-CoV-2

<400>  38

Gln Tyr Ile Lys Trp Pro Trp Tyr Ile 
1               5                   


