                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  GLP-1, GIP and glucagon receptor triple agonists

<130>  200078WO01

<150>  US 63/107,622
<151>  2020-10-30

<150>  EP 20213053.0
<151>  2020-12-10

<160>  62    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  1

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  2
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  2

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Lys Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  3
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  3

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Lys Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  4
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  4

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Lys Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  5
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  5

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Lys Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  6

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  7

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  8

Tyr Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  10

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Gln Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  11

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  12

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Gln Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  13

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Tyr Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  14

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  15

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Glu Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  16

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  17

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Tyr Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  18

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Tyr Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  19
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  19

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  20
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  20

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Lys Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  21
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  21

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Lys Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  22
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  22

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  23
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  23

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Glu Lys 
1               5                   10                  15      


Arg Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  24
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  24

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Leu Leu Glu Lys 
1               5                   10                  15      


Lys Tyr Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  25
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  25

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Leu Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  26
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  26

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Leu Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  27
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  27

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Leu Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  28
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  28

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Tyr Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  29
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  29

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Leu Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  30
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  30

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Leu Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Glu Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  31
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  31

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Leu Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Gln Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  32
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  32

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Leu Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala Arg Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  33
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  33

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Ile Leu Leu Glu Lys 
1               5                   10                  15      


Gln Ala Ala His Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  34
<211>  42
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<223>  murine GIP

<400>  34

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile Arg Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Arg Gly Lys 
            20                  25                  30          


Lys Ser Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  35
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human GLP-1(7-37)

<400>  35

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  36
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human GIP

<400>  36

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  37
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  human Glucagon

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  38
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  38

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  39

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  40
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  40

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Lys Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  41
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  41

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Lys Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  42
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  42

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  43
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  43

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Lys Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  44
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  44

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Lys Pro Pro Pro Ser 
        35                  


<210>  45
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is His or Tyr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is His or Gln

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Lys, Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Gln, Arg, or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Ala, Tyr or Lys

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Gln, Glu, Arg, His or Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Ala or Glu

<400>  45

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Xaa Lys 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Trp Leu Leu Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  46
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is His or Tyr

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is His or Gln

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Gln, Arg or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Ala, Tyr or Lys

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Gln, Glu, Arg, His or Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  Xaa is Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Ala or Glu

<400>  46

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Xaa Lys 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Val Xaa Trp Leu Leu Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  47
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Ala or Tyr

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Ala or Glu

<400>  47

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Xaa Lys 
1               5                   10                  15      


Xaa Xaa Ala Xaa Glu Phe Val Xaa Trp Leu Leu Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  48
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Ala or Tyr

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Ala or Glu

<400>  48

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Glu Lys 
1               5                   10                  15      


Xaa Xaa Ala Xaa Glu Phe Val Xaa Trp Leu Leu Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  49
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Ala or Tyr

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  49

His Xaa His Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Glu Lys 
1               5                   10                  15      


Xaa Xaa Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  50
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa is Ala or Tyr

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Asn or Gln

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa is Ala or Glu

<400>  50

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Xaa Lys 
1               5                   10                  15      


Xaa Xaa Ala Xaa Glu Phe Val Xaa Trp Leu Leu Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  51
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  51

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Glu Lys 
1               5                   10                  15      


Xaa Ala Ala Xaa Glu Phe Val Gln Trp Leu Leu Glu Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  52
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa is Ile or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa is Leu or Tyr

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  52

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Xaa Leu Asp Lys 
1               5                   10                  15      


Xaa Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  53
<211>  40
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  53

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  54
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  54

Ser Tyr Tyr Leu Glu 
1               5   


<210>  55
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  55

Ser Ile Leu Leu Glu 
1               5   


<210>  56
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  56

Ser Tyr Leu Leu Glu 
1               5   


<210>  57
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  57

Ser Ile Tyr Leu Glu 
1               5   


<210>  58
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  58

Ser Ile Tyr Leu Asp 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  59

Lys Gln Ala Ala Xaa 
1               5   


<210>  60
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  60

Lys Lys Ala Ala Xaa 
1               5   


<210>  61
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  61

Lys Gln Tyr Ala Xaa 
1               5   


<210>  62
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Aib (alpha-aminoisobutyric acid)

<400>  62

Lys Lys Tyr Ala Xaa 
1               5   


