                         SEQUENCE LISTING

<110>  ARES TRADING S.A.
 
<120>  PROTEINS FOR THE DETECTION OF SCHISTOSOMA INFECTION

<130>  P20-121 WO-PCT

<150>  EP20204189.3
<151>  2020 10 27

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  345
<212>  PRT
<213>  Schistosoma haematobium

<400>  1

Arg Thr Gly Tyr Gln Ile Gly Lys Thr Met Arg Leu Lys Ser Thr Ser 
1               5                   10                  15      


Ser Ser Trp Asn Ser Ser Glu Ala Gln Gln Glu Met Lys Ser Leu Tyr 
            20                  25                  30          


Gln Glu Leu Asn Asn Ser Leu Thr Ser Glu Lys Thr Phe Leu Asn Glu 
        35                  40                  45              


Lys Glu Glu Asn Val Val Arg Ile Ser Thr Gly Ile Phe Val Gln Lys 
    50                  55                  60                  


Thr Tyr Glu Val Glu Arg Arg Phe Thr Glu Ser Ile Ala Asn Asp Phe 
65                  70                  75                  80  


Glu Gly Glu Leu Lys Gln Val Asp Phe Ser Gln Arg Thr Ser Ala Thr 
                85                  90                  95      


Val Asp Ile Asn Asp Trp Val Asp Gln Gln Ser Asn Gly Leu Leu Glu 
            100                 105                 110         


Lys Phe Phe Thr Asp Asp Ile Pro Asp Asp Thr Ala Met Ile Leu Val 
        115                 120                 125             


Asn Val Phe Tyr Phe Arg Asp Phe Trp Gln Ser Pro Phe Glu Pro His 
    130                 135                 140                 


Tyr Thr Arg Met Glu Asn Phe Asp Ile Ser Ser Asp His Gln Ile Thr 
145                 150                 155                 160 


Val His Met Met Thr Gln Glu Gly Val Met Lys Tyr Gly Lys Phe Glu 
                165                 170                 175     


Asp Glu Gly Phe Glu Ile Val Ser Lys Pro Leu Asn Asn Thr Arg Phe 
            180                 185                 190         


Thr Phe Val Ile Val Leu Pro Leu Glu Lys Trp Ser Leu Asn Gly Ala 
        195                 200                 205             


Thr Glu Leu Leu Asn Gly Asn Lys Val Leu Ser Glu Tyr Val Lys Asn 
    210                 215                 220                 


Leu Lys Glu Thr Thr Val Ser Leu Arg Leu Pro Lys Phe Thr Leu Lys 
225                 230                 235                 240 


Asn Thr Leu Asp Leu Val Pro Thr Leu Lys Ser Ile Gly Val Val Asp 
                245                 250                 255     


Leu Phe Asp Pro Val Lys Ser Asp Leu Ser Gly Ile Thr Pro Asn His 
            260                 265                 270         


Asn Leu Tyr Val Asn Lys Phe Ile Gln Thr Asn Val Phe Lys Leu Asn 
        275                 280                 285             


Glu Ser Gly Ile Glu Ala Thr Thr Val Thr Ser Pro Ile Phe Val Pro 
    290                 295                 300                 


Ile Ser Ala Ile Ile Pro Glu Val Asp Phe His Val Thr His Pro Phe 
305                 310                 315                 320 


Ile Cys Phe Ile Tyr Asp Gln Gln Leu Thr Met Pro Ile Met Ala Ala 
                325                 330                 335     


Lys Val Met Asn Pro Ile Leu Gln Ser 
            340                 345 


<210>  2
<211>  112
<212>  PRT
<213>  Schistosoma haematobium

<400>  2

Cys Lys Tyr Cys Leu Arg Leu Tyr Asp Gly Thr Tyr Glu Asn Gly Ser 
1               5                   10                  15      


Tyr Thr Asp Val Tyr Lys Ser Val Gly Ser Leu Ser Pro Pro Trp Ile 
            20                  25                  30          


Pro Gly Ser Val Cys Val Pro Leu Ile His Asp Ser Lys Arg Gln Pro 
        35                  40                  45              


Pro Tyr Trp Arg Leu Tyr Glu Asp Val Asn Tyr Ser Gly Lys Asp Thr 
    50                  55                  60                  


Ala Ile Gly His Gly Ala Cys Ile Asp Asp Phe Thr Lys Ser Gly Leu 
65                  70                  75                  80  


Lys Arg Ile Ser Ser Ile Gln Lys Cys Val Tyr Gly Glu Asn Gly Met 
                85                  90                  95      


Val Gln Cys Ile Ser Glu Ser Lys Arg Gly Arg Lys Tyr Cys Arg Tyr 
            100                 105                 110         


<210>  3
<211>  74
<212>  PRT
<213>  Schistosoma haematobium

<400>  3

Lys Asp Arg Ile Asp Ser Glu Ile Asp Ala Leu Met Thr Gly Ala Leu 
1               5                   10                  15      


Asp Lys Pro Thr Pro Glu Ile Thr Glu Phe Met Asp Leu Ile Gln Ser 
            20                  25                  30          


Ser Phe His Cys Cys Gly Ala Lys Gly Pro Gln Asp Tyr Gly Pro Asn 
        35                  40                  45              


Ile Pro Ala Ser Cys Arg Gly Glu Thr Thr Val Tyr His Glu Gly Cys 
    50                  55                  60                  


Val Pro Val Phe Gly Ala Phe Leu Lys Arg 
65                  70                  


<210>  4
<211>  81
<212>  PRT
<213>  Schistosoma haematobium

<400>  4

Arg Asp Glu Val Lys Ser Gln Phe Leu Ser Leu Val Lys Ser Ser Val 
1               5                   10                  15      


Asn Glu Tyr Ser Lys Asn Pro Asp Phe Lys Asn Phe Leu Asp Lys Ile 
            20                  25                  30          


Gln Gln Glu Phe Gln Cys Cys Gly Ser Glu Ser Ser Ser Asp Tyr Thr 
        35                  40                  45              


Ser Ser Gly Gln Thr Val Pro Asp Ser Cys Lys Asp Thr Lys Thr Lys 
    50                  55                  60                  


Ala Ile Tyr Ser Asp Gly Cys Ser Tyr Lys Val Ile Ser Phe Phe Glu 
65                  70                  75                  80  


Lys 
    


<210>  5
<211>  78
<212>  PRT
<213>  Schistosoma haematobium

<400>  5

Glu Lys Pro Lys Val Lys Lys His Val Thr Asp Ala Leu Arg Glu Phe 
1               5                   10                  15      


Val Lys Glu Tyr Ser His Asp Glu His Val Ser Lys Val Leu Asp Glu 
            20                  25                  30          


Val Gln Gln Lys Leu Gln Cys Cys Gly Ala Asp Ser Ser Lys Asp Tyr 
        35                  40                  45              


Val Thr Pro Pro Pro Glu Ser Cys Phe Lys Asp Gly Gln Ile Phe Lys 
    50                  55                  60                  


Glu Gly Cys Val Lys Lys Val Ser Asp Leu Ser Lys Met His 
65                  70                  75              


<210>  6
<211>  225
<212>  PRT
<213>  Schistosoma haematobium

<400>  6

Met Ala Ser Leu Ser Cys Gly Tyr Lys Cys Leu Gln Ile Leu Leu Val 
1               5                   10                  15      


Ile Phe Asn Ile Leu Val Phe Ala Cys Gly Ile Ala Leu Ile Val Ile 
            20                  25                  30          


Gly Ser Leu Ser Gln Val Ala Ile Asn Asn Tyr Ser Ser Gly Ile Asp 
        35                  40                  45              


Ser Ser Ile Lys Gly Leu Val Ile Phe Val Ile Val Leu Gly Cys Phe 
    50                  55                  60                  


Leu Phe Leu Leu Gly Phe Leu Gly Phe Cys Gly Ala Cys Thr Lys Asn 
65                  70                  75                  80  


Thr Cys Cys Leu Ile Leu Tyr Ala Ile Leu Leu Ser Ile Met Val Ala 
                85                  90                  95      


Ala Glu Ile Ala Ala Gly Ile Thr Ala Ala Val Leu Arg Asp Glu Val 
            100                 105                 110         


Lys Ser Gln Phe Leu Ser Leu Val Lys Ser Ser Val Asn Glu Tyr Ser 
        115                 120                 125             


Lys Asn Pro Asp Phe Lys Asn Phe Leu Asp Lys Ile Gln Gln Glu Phe 
    130                 135                 140                 


Gln Cys Cys Gly Ser Glu Ser Ser Ser Asp Tyr Thr Ser Ser Gly Gln 
145                 150                 155                 160 


Thr Val Pro Asp Ser Cys Lys Asp Thr Lys Thr Lys Ala Ile Tyr Ser 
                165                 170                 175     


Asp Gly Cys Ser Tyr Lys Val Ile Ser Phe Phe Glu Lys Tyr Ile Val 
            180                 185                 190         


Ala Val Leu Val Ala Ala Phe Val Phe Ala Ile Leu Gln Leu Leu Cys 
        195                 200                 205             


Ile Val Phe Ala Ile Cys Val Ile Arg Ala Ile Lys Ser Gly Asp Ser 
    210                 215                 220                 


Asp 
225 


<210>  7
<211>  219
<212>  PRT
<213>  Schistosoma haematobium

<400>  7

Met Ala Leu Gly Cys Gly Tyr Lys Cys Ser Gln Cys Leu Leu Val Ile 
1               5                   10                  15      


Phe Asn Cys Gly Ala Phe Ile Cys Gly Leu Gly Leu Ile Val Val Gly 
            20                  25                  30          


Ala Leu Gly Leu His Ser Val Val Asn His Trp Lys Asp Ile Glu Pro 
        35                  40                  45              


Pro Leu Gln Ser Leu Ile Ile Phe Ile Ile Val Leu Gly Cys Phe Leu 
    50                  55                  60                  


Phe Val Leu Gly Ala Leu Gly Met Phe Gly Ala Cys Thr Lys Asn Val 
65                  70                  75                  80  


Cys Leu Leu Thr Thr Tyr Cys Ile Leu Leu Ser Ile Leu Ile Val Ala 
                85                  90                  95      


Glu Ile Ala Ala Gly Ile Phe Ala Ile Leu Glu Lys Pro Lys Val Lys 
            100                 105                 110         


Lys His Val Thr Asp Ala Leu Arg Glu Phe Val Lys Glu Tyr Ser His 
        115                 120                 125             


Asp Glu His Val Ser Lys Val Leu Asp Glu Val Gln Gln Lys Leu Gln 
    130                 135                 140                 


Cys Cys Gly Ala Asp Ser Ser Lys Asp Tyr Val Thr Pro Pro Pro Glu 
145                 150                 155                 160 


Ser Cys Phe Lys Asp Gly Gln Ile Phe Lys Glu Gly Cys Val Lys Lys 
                165                 170                 175     


Val Ser Asp Leu Ser Lys Met His Leu Asn Ala Ile Ile Ile Ser Val 
            180                 185                 190         


Phe Leu Phe Ser Leu Val Gln Met Ile Cys Leu Val Phe Ala Val Cys 
        195                 200                 205             


Val Leu Leu Ala Val Lys Arg Gly Asp Asp Glu 
    210                 215                 


<210>  8
<211>  218
<212>  PRT
<213>  Schistosoma haematobium

<400>  8

Met Ala Thr Leu Gly Thr Gly Met Arg Cys Leu Lys Ser Cys Val Phe 
1               5                   10                  15      


Val Leu Asn Ile Ile Cys Leu Leu Cys Ser Leu Val Leu Ile Gly Ala 
            20                  25                  30          


Gly Ala Tyr Val Glu Val Lys Phe Ser Gln Tyr Gly Asp Asn Leu His 
        35                  40                  45              


Lys Val Trp Gln Ala Ala Pro Ile Ala Ile Ile Val Val Gly Val Ile 
    50                  55                  60                  


Ile Leu Ile Val Ser Phe Leu Gly Cys Cys Gly Ala Ile Lys Glu Asn 
65                  70                  75                  80  


Val Cys Met Leu Tyr Met Tyr Ala Phe Phe Leu Ile Ile Leu Leu Ile 
                85                  90                  95      


Ala Glu Leu Ala Ala Ala Ile Val Ala Val Val Tyr Lys Asp Arg Ile 
            100                 105                 110         


Asp Ser Glu Ile Asp Ala Leu Met Thr Gly Ala Leu Asp Lys Pro Thr 
        115                 120                 125             


Pro Glu Ile Thr Glu Phe Met Asp Leu Ile Gln Ser Ser Phe His Cys 
    130                 135                 140                 


Cys Gly Ala Lys Gly Pro Gln Asp Tyr Gly Pro Asn Ile Pro Ala Ser 
145                 150                 155                 160 


Cys Arg Gly Glu Thr Thr Val Tyr His Glu Gly Cys Val Pro Val Phe 
                165                 170                 175     


Gly Ala Phe Leu Lys Arg Asn Leu Val Ile Val Ala Cys Val Ala Phe 
            180                 185                 190         


Gly Val Cys Phe Phe Gln Leu Leu Ser Ile Val Ile Ala Cys Cys Leu 
        195                 200                 205             


Gly Arg Gln Ile Lys Glu Tyr Glu Asn Val 
    210                 215             


<210>  9
<211>  372
<212>  PRT
<213>  Schistosoma haematobium

<400>  9

Gly Gly Asp Asn Phe Leu Thr Cys Pro Leu Gly Ile Leu Phe Thr Leu 
1               5                   10                  15      


Gly Ile Leu Leu Gly Ser Gly Gly Ala Gln Gly Arg Thr Gly Tyr Gln 
            20                  25                  30          


Ile Gly Lys Thr Met Arg Leu Lys Ser Thr Ser Ser Ser Trp Asn Ser 
        35                  40                  45              


Ser Glu Ala Gln Gln Glu Met Lys Ser Leu Tyr Gln Glu Leu Asn Asn 
    50                  55                  60                  


Ser Leu Thr Ser Glu Lys Thr Phe Leu Asn Glu Lys Glu Glu Asn Val 
65                  70                  75                  80  


Val Arg Ile Ser Thr Gly Ile Phe Val Gln Lys Thr Tyr Glu Val Glu 
                85                  90                  95      


Arg Arg Phe Thr Glu Ser Ile Ala Asn Asp Phe Glu Gly Glu Leu Lys 
            100                 105                 110         


Gln Val Asp Phe Ser Gln Arg Thr Ser Ala Thr Val Asp Ile Asn Asp 
        115                 120                 125             


Trp Val Asp Gln Gln Ser Asn Gly Leu Leu Glu Lys Phe Phe Thr Asp 
    130                 135                 140                 


Asp Ile Pro Asp Asp Thr Ala Met Ile Leu Val Asn Val Phe Tyr Phe 
145                 150                 155                 160 


Arg Asp Phe Trp Gln Ser Pro Phe Glu Pro His Tyr Thr Arg Met Glu 
                165                 170                 175     


Asn Phe Asp Ile Ser Ser Asp His Gln Ile Thr Val His Met Met Thr 
            180                 185                 190         


Gln Glu Gly Val Met Lys Tyr Gly Lys Phe Glu Asp Glu Gly Phe Glu 
        195                 200                 205             


Ile Val Ser Lys Pro Leu Asn Asn Thr Arg Phe Thr Phe Val Ile Val 
    210                 215                 220                 


Leu Pro Leu Glu Lys Trp Ser Leu Asn Gly Ala Thr Glu Leu Leu Asn 
225                 230                 235                 240 


Gly Asn Lys Val Leu Ser Glu Tyr Val Lys Asn Leu Lys Glu Thr Thr 
                245                 250                 255     


Val Ser Leu Arg Leu Pro Lys Phe Thr Leu Lys Asn Thr Leu Asp Leu 
            260                 265                 270         


Val Pro Thr Leu Lys Ser Ile Gly Val Val Asp Leu Phe Asp Pro Val 
        275                 280                 285             


Lys Ser Asp Leu Ser Gly Ile Thr Pro Asn His Asn Leu Tyr Val Asn 
    290                 295                 300                 


Lys Phe Ile Gln Thr Asn Val Phe Lys Leu Asn Glu Ser Gly Ile Glu 
305                 310                 315                 320 


Ala Thr Thr Val Thr Ser Pro Ile Phe Val Pro Ile Ser Ala Ile Ile 
                325                 330                 335     


Pro Glu Val Asp Phe His Val Thr His Pro Phe Ile Cys Phe Ile Tyr 
            340                 345                 350         


Asp Gln Gln Leu Thr Met Pro Ile Met Ala Ala Lys Val Met Asn Pro 
        355                 360                 365             


Ile Leu Gln Ser 
    370         


<210>  10
<211>  134
<212>  PRT
<213>  Schistosoma haematobium

<400>  10

Met Phe Leu Ile Ala Leu Leu Ser Tyr Thr Leu Ile Asn Gln Leu Gly 
1               5                   10                  15      


Ile Thr Lys Ser Asn Pro Cys Lys Tyr Cys Leu Arg Leu Tyr Asp Gly 
            20                  25                  30          


Thr Tyr Glu Asn Gly Ser Tyr Thr Asp Val Tyr Lys Ser Val Gly Ser 
        35                  40                  45              


Leu Ser Pro Pro Trp Ile Pro Gly Ser Val Cys Val Pro Leu Ile His 
    50                  55                  60                  


Asp Ser Lys Arg Gln Pro Pro Tyr Trp Arg Leu Tyr Glu Asp Val Asn 
65                  70                  75                  80  


Tyr Ser Gly Lys Asp Thr Ala Ile Gly His Gly Ala Cys Ile Asp Asp 
                85                  90                  95      


Phe Thr Lys Ser Gly Leu Lys Arg Ile Ser Ser Ile Gln Lys Cys Val 
            100                 105                 110         


Tyr Gly Glu Asn Gly Met Val Gln Cys Ile Ser Glu Ser Lys Arg Gly 
        115                 120                 125             


Arg Lys Tyr Cys Arg Tyr 
    130                 


