               SEQUENCE LISTING

<110> Universidad Pablo de Olavide OTRI

<120> Sulfated C19 steroid hormones to treat and/or prevent
proteotoxicity in protein-aggregation diseases

<130> 906 726 

<140> 
<141> 

<160> 13

<170> BiSSAP 1.3.6

<210> 1
<211> 60
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence SUL-2

<400> 1
Pro Asn Ile Val Ile Leu Met Ile Asp Asp Leu Gly Tyr Gly Asp Ile 
1               5                   10                  15      
Ala Ser Tyr Gly His Pro Thr Gln Glu Tyr Thr Gln Val Asp Arg Met 
            20                  25                  30          
Ala Ala Glu Gly Thr Arg Phe Thr Gln Ala Tyr Ser Ala Asp Ser Met 
        35                  40                  45              
Cys Ser Pro Ser Arg Ala Gly Phe Ile Thr Gly Arg 
    50                  55                  60  

<210> 2
<211> 60
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence ARSC

<400> 2
Pro Asn Ile Ile Leu Val Met Ala Asp Asp Leu Gly Ile Gly Asp Pro 
1               5                   10                  15      
Gly Cys Tyr Gly Asn Lys Thr Ile Arg Thr Pro Asn Ile Asp Arg Leu 
            20                  25                  30          
Ala Ser Gly Gly Val Lys Leu Thr Gln His Leu Ala Ala Ser Pro Leu 
        35                  40                  45              
Cys Thr Pro Ser Arg Ala Ala Phe Met Thr Gly Arg 
    50                  55                  60  

<210> 3
<211> 60
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence ARSD

<400> 3
Pro Asn Ile Leu Leu Ile Met Ala Asp Asp Leu Gly Thr Gly Asp Leu 
1               5                   10                  15      
Gly Cys Tyr Gly Asn Asn Thr Leu Arg Thr Pro Asn Ile Asp Gln Leu 
            20                  25                  30          
Ala Glu Glu Gly Val Arg Leu Thr Gln His Leu Ala Ala Ala Pro Leu 
        35                  40                  45              
Cys Thr Pro Ser Arg Ala Ala Phe Leu Thr Gly Arg 
    50                  55                  60  

<210> 4
<211> 59
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence ARSE

<400> 4
Pro Asn Ile Leu Leu Leu Met Ala Asp Asp Leu Gly Ile Gly Asp Ile 
1               5                   10                  15      
Gly Cys Tyr Gly Asn Asn Thr Met Arg Thr Pro Asn Ile Arg Leu Ala 
            20                  25                  30          
Glu Asp Gly Val Lys Leu Thr Gln His Ile Ser Ala Ala Ser Leu Cys 
        35                  40                  45              
Thr Pro Ser Arg Ala Ala Phe Leu Thr Gly Arg 
    50                  55                  

<210> 5
<211> 60
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence ARSH

<400> 5
Pro Asn Ile Val Leu Leu Met Ala Asp Asp Leu Gly Val Gly Asp Leu 
1               5                   10                  15      
Cys Cys Tyr Gly Asn Asn Ser Val Ser Thr Pro Asn Ile Asp Arg Leu 
            20                  25                  30          
Ala Ser Glu Gly Val Arg Leu Thr Gln His Leu Ala Ala Ala Ser Met 
        35                  40                  45              
Cys Thr Pro Ser Arg Ala Ala Phe Leu Thr Gly Arg 
    50                  55                  60  

<210> 6
<211> 60
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence ARSF

<400> 6
Pro Asn Ile Val Leu Ile Met Val Asp Asp Leu Gly Ile Gly Asp Leu 
1               5                   10                  15      
Gly Cys Tyr Gly Asn Asp Thr Met Arg Thr Pro His Ile Asp Arg Leu 
            20                  25                  30          
Ala Arg Glu Gly Val Arg Leu Thr Gln His Ile Ser Ala Ala Ser Leu 
        35                  40                  45              
Cys Ser Pro Ser Arg Ser Ala Phe Leu Thr Gly Arg 
    50                  55                  60  

<210> 7
<211> 60
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence ARSG

<400> 7
Pro Asn Phe Val Ile Ile Leu Ala Asp Asp Met Gly Trp Gly Asp Leu 
1               5                   10                  15      
Gly Ala Asn Trp Ala Glu Thr Lys Asp Thr Ala Asn Leu Asp Lys Met 
            20                  25                  30          
Ala Ser Glu Gly Met Arg Phe Val Asp Phe His Ala Ala Ala Ser Thr 
        35                  40                  45              
Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Arg 
    50                  55                  60  

<210> 8
<211> 60
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence ARSA

<400> 8
Pro Asn Ile Val Leu Ile Phe Ala Asp Asp Leu Gly Tyr Gly Asp Leu 
1               5                   10                  15      
Gly Cys Tyr Gly His Pro Ser Ser Thr Thr Pro Asn Leu Asp Gln Leu 
            20                  25                  30          
Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe Tyr Val Pro Val Ser Leu 
        35                  40                  45              
Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr Gly Arg 
    50                  55                  60  

<210> 9
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence SUL-2_wormbase

<400> 9
Ser Lys Arg Phe Arg Gly Ser Ser Lys Glu Ala 
1               5                   10      

<210> 10
<211> 117
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence SUL-2_modified

<400> 10
Ser Lys Arg Phe Arg Gly Ser Ser Ile Tyr Gly Asp Ser Ile Asn Glu 
1               5                   10                  15      
Met Ser Trp Ala Val Gly Glu Val Leu Asp Ser Leu Val Asn Ala Gly 
            20                  25                  30          
Ile Ala Glu Asn Thr Leu Val Ile Leu Met Ser Asp His Gly Pro His 
        35                  40                  45              
Val Glu Leu Cys Leu Asn Gly Gly Ser Thr Ala Gly Leu Lys Gly Gly 
    50                  55                  60                  
Lys Ser Asn Ser Tyr Glu Gly Gly Phe Arg Ile Pro Phe Ile Ala Trp 
65                  70                  75                  80  
Gln Pro Gly Thr Val Lys Pro Ser Arg Val Ser His Glu Val Ile Ser 
                85                  90                  95      
Ser Met Asp Leu Phe Pro Thr Phe Arg Gly Met Gln Glu Gln Cys Leu 
            100                 105                 110         
Phe Glu Lys Glu Ala 
        115         

<210> 11
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence SUL-2_curated

<400> 11
Ser Lys Arg Phe Arg Gly Ser Ser Val Arg Gly Ile Tyr Gly Asp Ser 
1               5                   10                  15      
Ile Asn Glu Met Ser Trp Ala Val Gly Glu Val Leu Asp Ser Leu Val 
            20                  25                  30          
Asn Ala Gly Ile Ala Glu Asn Thr Leu Val Ile Leu Met Ser Asp His 
        35                  40                  45              
Gly Pro His Val Glu Leu Cys Leu Asn Gly Gly Ser Thr Ala Gly Leu 
    50                  55                  60                  
Lys Gly Gly Lys Ser Asn Ser Tyr Glu Gly Gly Phe Arg Ile Pro Phe 
65                  70                  75                  80  
Ile Ala Trp Gln Pro Gly Thr Val Lys Pro Ser Arg Val Ser His Glu 
                85                  90                  95      
Val Ile Ser Ser Met Asp Leu Phe Pro Thr Phe Arg Gly Met Gln Glu 
            100                 105                 110         
Gln Cys Leu Phe Glu Lys Glu Ala 
        115                 120 

<210> 12
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig. 6 Sequence CRE-SUL-2

<400> 12
Ser Lys Arg Phe Arg Gly Ser Ser Val Arg Gly Ile Tyr Gly Asp Ser 
1               5                   10                  15      
Ile Asn Glu Met Ser Trp Ala Val Gly Glu Val Leu Asp Ser Leu Val 
            20                  25                  30          
Asn Ala Gly Ile Ala Glu Asn Thr Leu Val Ile Leu Met Ser Asp His 
        35                  40                  45              
Gly Pro His Val Glu Leu Cys Leu Asn Gly Gly Ser Thr Ala Gly Leu 
    50                  55                  60                  
Lys Gly Gly Lys Ser Asn Ser Tyr Glu Gly Gly Phe Arg Ile Pro Phe 
65                  70                  75                  80  
Ile Ala Trp Gln Pro Gly Thr Val Lys Pro Ser Arg Val Ser His Glu 
                85                  90                  95      
Val Val Ser Ser Met Asp Leu Phe Pro Thr Phe Arg Ala Met Asn Glu 
            100                 105                 110         
Glu Cys Leu Phe Glu Lys Glu Ala 
        115                 120 

<210> 13
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Fig 6 Sequence CBR-SUL-2

<400> 13
Ser Lys Arg Phe Arg Gly Ser Ser Val Arg Gly Ile Tyr Gly Asp Ser 
1               5                   10                  15      
Ile Asn Glu Met Ser Trp Ala Val Gly Glu Val Leu Asp Ser Leu Val 
            20                  25                  30          
Asn Ala Gly Ile Ala Glu Asn Thr Leu Val Ile Leu Met Ser Asp His 
        35                  40                  45              
Gly Pro His Val Glu Leu Cys Leu Asn Gly Gly Ser Thr Ala Gly Leu 
    50                  55                  60                  
Lys Gly Gly Lys Ser Asn Ser Tyr Glu Gly Gly Phe Arg Ile Pro Phe 
65                  70                  75                  80  
Ile Ala Trp Gln Pro Gly Thr Val Lys Pro Ser Arg Val Ser His Glu 
                85                  90                  95      
Val Ile Ser Ser Met Asp Leu Phe Pro Thr Phe Arg Ala Met Asn Glu 
            100                 105                 110         
Glu Cys Leu Phe Glu Lys Glu Ala 
        115                 120 

