                         SEQUENCE LISTING

<110>  UCB Biopharma SRL
 
<120>  PROTEINS AND THIER USES

<130>  PF0183-WO-PCT2

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Ala Thr Lys Leu Thr Glu Glu Lys Tyr Glu Leu Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Asp Val Lys Cys Asp Tyr Thr Leu Glu Lys Phe 
        35                  40                  45              


Ala Ser Ser Gln Lys Ala Trp Gln Ile Ile Arg Asp Gly Glu Met Pro 
    50                  55                  60                  


Lys Thr Leu Ala Cys Thr Glu Arg Pro Ser Lys Asn Ser His Pro Val 
65                  70                  75                  80  


Gln Val Gly Arg Ile Ile Leu Glu Asp Tyr His Asp His Gly Leu Leu 
                85                  90                  95      


Arg Val Arg Met Val Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln 
            100                 105                 110         


Cys Val Ile Tyr Gln Pro Pro Lys Glu Pro His Met Leu Phe Asp Arg 
        115                 120                 125             


Ile Arg Leu Val Val Thr Lys Gly Phe Ser Gly Thr Pro Gly Ser Asn 
    130                 135                 140                 


Glu Asn Ser Thr Gln Asn Val Tyr Lys Ile Pro Pro Thr Thr Thr Lys 
145                 150                 155                 160 


Ala Leu Cys Pro Leu Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro 
                165                 170                 175     


Pro Lys Ser Thr Ala Asp Val Ser Thr Pro Asp Ser Glu Ile Asn Leu 
            180                 185                 190         


Thr Asn Val Thr Asp Ile Ile Arg Val Pro Val Phe Asn Ile Val Ile 
        195                 200                 205             


Leu Leu Ala Gly Gly Phe Leu Ser Lys Ser Leu Val Phe Ser Val Leu 
    210                 215                 220                 


Phe Ala Val Thr Leu Arg Ser Phe Val Pro 
225                 230                 


<210>  2
<211>  230
<212>  PRT
<213>  Mus musculus

<400>  2

Met Arg Lys Ala Gly Leu Trp Gly Leu Leu Cys Val Phe Phe Val Ser 
1               5                   10                  15      


Glu Val Lys Ala Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val 
            20                  25                  30          


Glu Gly Gln Thr Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr 
        35                  40                  45              


Ala Asn Ser Gln Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro 
    50                  55                  60                  


Leu Thr Leu Val Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val 
65                  70                  75                  80  


His Met Gly Lys Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu 
                85                  90                  95      


Gln Val Gln Met Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg 
            100                 105                 110         


Cys Val Ile Tyr His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro 
        115                 120                 125             


Val Arg Leu Val Val Thr Lys Gly Ser Ser Asp Val Phe Thr Pro Val 
    130                 135                 140                 


Ile Ile Pro Ile Thr Arg Leu Thr Glu Arg Pro Ile Leu Ile Thr Thr 
145                 150                 155                 160 


Lys Tyr Ser Pro Ser Asp Thr Thr Thr Thr Arg Ser Leu Pro Lys Pro 
                165                 170                 175     


Thr Ala Val Val Ser Ser Pro Gly Leu Gly Val Thr Ile Ile Asn Gly 
            180                 185                 190         


Thr Asp Ala Asp Ser Val Ser Thr Ser Ser Val Thr Ile Ser Val Ile 
        195                 200                 205             


Cys Gly Leu Leu Ser Lys Ser Leu Val Phe Ile Ile Leu Phe Ile Val 
    210                 215                 220                 


Thr Lys Arg Thr Phe Gly 
225                 230 


<210>  3
<211>  226
<212>  PRT
<213>  Rattus norvegicus

<400>  3

Met Arg Lys Ala Gly Leu Trp Gly Leu Leu Leu Val Phe Phe Val Ser 
1               5                   10                  15      


Glu Val Lys Ala Ala Ile Val Pro Glu Glu Glu Arg Tyr Asp Leu Val 
            20                  25                  30          


Glu Gly Gln Thr Leu Thr Val Asn Cys Pro Phe Asn Ile Met Lys Tyr 
        35                  40                  45              


Ala Arg Ser Arg Lys Ala Trp Gln Arg Leu Ser Ala Gly Lys Glu Pro 
    50                  55                  60                  


Leu Thr Leu Val Val Thr Glu Arg Ser Ser Thr Thr Ser Ser Glu Val 
65                  70                  75                  80  


Arg Val Gly Lys Tyr Thr Leu Lys Asp Asp Pro Thr Glu Ala Met Leu 
                85                  90                  95      


Phe Val Gln Met Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg 
            100                 105                 110         


Cys Val Ile Tyr His Pro Pro Asn Asp Pro Val Leu Leu Phe His Pro 
        115                 120                 125             


Val Arg Leu Val Val Thr Lys Gly Ser Ser Gly Val Ser Val Pro Asp 
    130                 135                 140                 


Ile Ile Pro Thr Thr Lys Pro Thr Glu Val Pro Val Leu Ile Thr Thr 
145                 150                 155                 160 


Lys His Ser Thr Pro Thr Arg Ser Leu Pro Lys Ser Thr Ala Val Val 
                165                 170                 175     


Ser Ser Pro Asp Pro Gly Val Thr Ile Asn Asn Gly Thr Asp Pro Thr 
            180                 185                 190         


Ser Val Ser Thr Tyr Asn Val Val Val Pro Val Val Cys Gly Leu Leu 
        195                 200                 205             


Ile Lys Thr Leu Ile Phe Phe Val Leu Phe Val Val Thr Lys Arg Ser 
    210                 215                 220                 


Phe Gly 
225     


<210>  4
<211>  201
<212>  PRT
<213>  Macaca mulatta

<400>  4

Met Arg Lys Thr Arg Leu Trp Gly Leu Leu Trp Met Leu Phe Val Ser 
1               5                   10                  15      


Glu Leu Arg Ala Thr Thr Glu Leu Thr Glu Glu Lys Tyr Glu Tyr Lys 
            20                  25                  30          


Glu Gly Gln Thr Leu Glu Val Lys Cys Asp Tyr Ala Leu Glu Lys Tyr 
        35                  40                  45              


Ala Asn Ser Arg Lys Ala Trp Gln Lys Met Glu Gly Lys Met Pro Lys 
    50                  55                  60                  


Ile Leu Ala Lys Thr Glu Arg Pro Ser Glu Asn Ser His Pro Val Gln 
65                  70                  75                  80  


Val Gly Arg Ile Thr Leu Glu Asp Tyr Pro Asp His Gly Leu Leu Gln 
                85                  90                  95      


Val Gln Met Thr Asn Leu Gln Val Glu Asp Ser Gly Leu Tyr Gln Cys 
            100                 105                 110         


Val Ile Tyr Gln His Pro Lys Glu Ser His Val Leu Phe Asn Pro Ile 
        115                 120                 125             


Cys Leu Val Val Thr Lys Gly Ser Ser Gly Thr Pro Gly Ser Ser Glu 
    130                 135                 140                 


Asn Ser Thr Gln Asn Val Tyr Arg Thr Pro Ser Thr Thr Ala Lys Ala 
145                 150                 155                 160 


Leu Gly Pro Arg Tyr Thr Ser Pro Arg Thr Val Thr Gln Ala Pro Pro 
                165                 170                 175     


Glu Ser Thr Val Val Val Ser Thr Pro Gly Pro Gly Pro Leu Pro Phe 
            180                 185                 190         


Phe Pro Ser Pro Cys Ala Glu Arg Met 
        195                 200     


<210>  5
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  5

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  6
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant protein

<400>  6

Ala Ala Ala Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  7
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  7

Ala Ile Ala Ala Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  8
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  8

Ala Ile Val Ala Ala Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  9
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  9

Ala Ile Val Leu Glu Ala Ala Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  10
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  10

Ala Ile Val Leu Glu Glu Ala Ala Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  11
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  11

Ala Ile Val Leu Glu Glu Glu Arg Tyr Ala Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Ala 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  12
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  12

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Ala Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Ala Lys Gly 
        115     


<210>  13
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  13

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Ala Ala 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  14
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  14

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Ala Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Ala Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  15
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  15

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Ala Cys Ala Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  16
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  16

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Ala Ala Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  17
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  17

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ala Ala Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  18
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  18

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Ala Ala Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  19
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  19

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Ala Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Ala Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  20
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  20

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Ala Gly Ala Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  21
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  21

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Ala Ala Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  22
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  22

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Ala Pro Ala Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  23
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  23

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Ala Ala Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  24
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  24

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Ala Ala Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  25
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  25

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Ala Ala Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  26
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  26

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Ala Ala Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  27
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  27

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Ala Ala Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  28
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  28

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ala Ala Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  29
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  29

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val Ala Ala Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  30
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  30

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Ala Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Ala His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  31
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  31

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Ala Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Ala Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  32
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  32

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ala Ala Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  33
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  33

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Ala Ala Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  34
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  34

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Ala Ala Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  35
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  35

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Ala Ala Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  36
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  36

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


Ala Ala Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  37
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  37

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Ala Ala Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  38
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  38

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Ala Ala Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  39
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  39

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Ala Ala Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  40
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  40

Ala Ile Val Leu Glu Ala Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe Ala Pro Val Arg Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  41
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  41

Ala Ile Val Leu Glu Glu Glu Ala Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Ala Leu Val 
            100                 105                 110         


Val Thr Lys Gly 
        115     


<210>  42
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutant sequence

<400>  42

Ala Ile Val Leu Glu Glu Glu Arg Tyr Asp Leu Val Glu Gly Gln Thr 
1               5                   10                  15      


Leu Thr Val Lys Cys Pro Phe Asn Ile Met Lys Tyr Ala Asn Ser Gln 
            20                  25                  30          


Lys Ala Trp Gln Arg Leu Pro Asp Gly Lys Glu Pro Leu Thr Leu Val 
        35                  40                  45              


Val Thr Gln Arg Pro Phe Thr Arg Pro Ser Glu Val His Met Gly Lys 
    50                  55                  60                  


Phe Thr Leu Lys His Asp Pro Ser Glu Ala Met Leu Gln Val Gln Met 
65                  70                  75                  80  


Thr Asp Leu Gln Val Thr Asp Ser Gly Leu Tyr Arg Cys Val Ile Tyr 
                85                  90                  95      


His Pro Pro Asn Asp Pro Val Val Leu Phe His Pro Val Arg Leu Val 
            100                 105                 110         


Val Ala Ala Gly 
        115     


