                         SEQUENCE LISTING
<110>  йѧԺо
<120>  һIL-2뿹ǵλɵ˫ںϵ
<160>  61    

<210>  1
<211>  133
<212>  PRT
<213>  Homo sapiens
<400>  1
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  2
<211>  227
<212>  PRT
<213>  Homo sapiens
<400>  2
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  3
<211>  227
<212>  PRT
<213>  Homo sapiens
<400>  3
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Gly Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  4
<211>  227
<212>  PRT
<213>  Homo sapiens
<400>  4
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Val Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  5
<211>  227
<212>  PRT
<213>  Homo sapiens
<400>  5
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  6
<211>  15
<212>  PRT
<213>  ˹
<400>  6
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  7
<211>  217
<212>  PRT
<213>  ˹
<400>  7
Asp Ile Val Met Thr Gln Ala Ala Leu Pro Asn Pro Val Pro Ser Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser Leu Val Tyr Lys 
            20                  25                  30          


Asp Gly Gln Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Thr Tyr Trp Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Arg Ala Glu Asp Ala Gly Val Tyr Tyr Cys Gln Gln Val 
                85                  90                  95      


Arg Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  8
<211>  220
<212>  PRT
<213>  ˹
<400>  8
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Asn Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220 


<210>  9
<211>  244
<212>  PRT
<213>  ˹
<400>  9
Asp Ile Val Met Thr Gln Ala Ala Leu Pro Asn Pro Val Pro Ser Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser Leu Val Tyr Lys 
            20                  25                  30          


Asp Gly Gln Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Thr Tyr Trp Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Arg Ala Glu Asp Ala Gly Val Tyr Tyr Cys Gln Gln Val 
                85                  90                  95      


Arg Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Asn 
145                 150                 155                 160 


Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys Ser 
            180                 185                 190         


Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Thr Arg 
    210                 215                 220                 


Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Val Met Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  10
<211>  375
<212>  PRT
<213>  ˹
<400>  10
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
145                 150                 155                 160 


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
                165                 170                 175     


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
            180                 185                 190         


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
        195                 200                 205             


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
    210                 215                 220                 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
225                 230                 235                 240 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
                245                 250                 255     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
            260                 265                 270         


Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
        275                 280                 285             


Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp 
    290                 295                 300                 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
305                 310                 315                 320 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Lys Leu Val Ser 
                325                 330                 335     


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
            340                 345                 350         


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
        355                 360                 365             


Leu Ser Leu Ser Pro Gly Lys 
    370                 375 


<210>  11
<211>  447
<212>  PRT
<213>  ˹
<400>  11
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Asn Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Val Met 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  12
<211>  471
<212>  PRT
<213>  ˹
<400>  12
Asp Ile Val Met Thr Gln Ala Ala Leu Pro Asn Pro Val Pro Ser Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser Leu Val Tyr Lys 
            20                  25                  30          


Asp Gly Gln Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Thr Tyr Trp Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Arg Ala Glu Asp Ala Gly Val Tyr Tyr Cys Gln Gln Val 
                85                  90                  95      


Arg Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Asn 
145                 150                 155                 160 


Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys Ser 
            180                 185                 190         


Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Thr Arg 
    210                 215                 220                 


Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Val Met Val 
225                 230                 235                 240 


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Ala Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  13
<211>  619
<212>  PRT
<213>  ˹
<400>  13
Asp Ile Val Met Thr Gln Ala Ala Leu Pro Asn Pro Val Pro Ser Gly 
1               5                   10                  15      


Glu Ser Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser Leu Val Tyr Lys 
            20                  25                  30          


Asp Gly Gln Thr Tyr Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Thr Tyr Trp Met Ser Thr Arg Ala Ser Gly Val Ser 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Arg Ala Glu Asp Ala Gly Val Tyr Tyr Cys Gln Gln Val 
                85                  90                  95      


Arg Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr Asn 
145                 150                 155                 160 


Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser Val Leu Lys Ser 
            180                 185                 190         


Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Phe Leu Lys 
        195                 200                 205             


Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr Tyr Cys Thr Arg 
    210                 215                 220                 


Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln Gly Val Met Val 
225                 230                 235                 240 


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
                485                 490                 495     


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            500                 505                 510         


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        515                 520                 525             


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    530                 535                 540                 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
545                 550                 555                 560 


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                565                 570                 575     


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            580                 585                 590         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        595                 600                 605             


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
    610                 615                 


<210>  14
<211>  619
<212>  PRT
<213>  ˹
<400>  14
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ala Ala Leu Pro Asn Pro 
145                 150                 155                 160 


Val Pro Ser Gly Glu Ser Ala Ser Ile Thr Cys Arg Ser Ser Gln Ser 
                165                 170                 175     


Leu Val Tyr Lys Asp Gly Gln Thr Tyr Leu Asn Trp Phe Leu Gln Arg 
            180                 185                 190         


Pro Gly Gln Ser Pro Gln Leu Leu Thr Tyr Trp Met Ser Thr Arg Ala 
        195                 200                 205             


Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe 
    210                 215                 220                 


Thr Leu Lys Ile Ser Arg Val Arg Ala Glu Asp Ala Gly Val Tyr Tyr 
225                 230                 235                 240 


Cys Gln Gln Val Arg Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
                245                 250                 255     


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            260                 265                 270         


Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Gln 
        275                 280                 285             


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
    290                 295                 300                 


Thr Gly Tyr Asn Leu His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
305                 310                 315                 320 


Glu Trp Met Gly Arg Met Arg Tyr Asp Gly Asp Thr Tyr Tyr Asn Ser 
                325                 330                 335     


Val Leu Lys Ser Arg Leu Ser Ile Ser Arg Asp Thr Ser Lys Asn Gln 
            340                 345                 350         


Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr 
        355                 360                 365             


Tyr Cys Thr Arg Asp Gly Arg Gly Asp Ser Phe Asp Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Val Met Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
385                 390                 395                 400 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                405                 410                 415     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            420                 425                 430         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        435                 440                 445             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    450                 455                 460                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
465                 470                 475                 480 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                485                 490                 495     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            500                 505                 510         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        515                 520                 525             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    530                 535                 540                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
545                 550                 555                 560 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                565                 570                 575     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            580                 585                 590         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        595                 600                 605             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 


<210>  15
<211>  1185
<212>  DNA
<213>  ˹
<400>  15
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gcggcggcgg cagcggcggc      480

ggcggcagcg gcggcggcgg cagcgacaaa actcacacat gcccaccgtg cccagctccg      540

gaactcctgg gcggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      600

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      660

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      720

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac      780

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc      840

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgtg taccctgccc      900

ccatcccggg atgagctgac caagaaccag gtcagcctga gttgcgcggt caaaggcttc      960

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1020

accacgcctc ccgtgttgga ctccgacggc tccttcaagc tcgtcagcaa gctcaccgtg     1080

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1140

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaa                     1185


<210>  16
<211>  651
<212>  DNA
<213>  ˹
<400>  16
gatattgtga tgacgcaggc tgcactcccc aatcctgtcc cttctggaga gtcagcttcc       60

atcacctgca ggtctagtca gagtctggta tacaaagacg gccagacata cttgaattgg      120

tttctgcaga ggccaggaca gtctcctcag cttctgacct attggatgtc tacccgtgca      180

tcaggagtct cagacaggtt cagtggcagt gggtcaggaa catatttcac actgaaaatc      240

agtagagtga gggctgagga tgcgggtgtg tattactgtc agcaagttcg agagtatcct      300

ttcactttcg gctcagggac gaagttggaa ataaaagtgg ctgcaccatc tgtcttcatc      360

ttcccgccat ctgatgagca gttgaaatct ggtaccgcta gcgttgtgtg cctgctgaat      420

aacttttatc cacgggaggc taaggtgcag tggaaagtgg acaatgccct ccagagcgga      480

aatagccaag agtccgttac cgaacaggac tctaaagact ctacatactc cctgtcctcc      540

acactgaccc tctccaaggc cgactatgag aaacacaagg tttacgcatg cgaggtcaca      600

caccagggac tctcctctcc cgtgaccaag agcttcaacc ggggagaatg c               651


<210>  17
<211>  1341
<212>  DNA
<213>  ˹
<400>  17
caggtgcagc tgaaggagtc aggacctggt ctggtgcagc cctcacagac cctgtccctc       60

acctgcactg tctctgggtt ctcactaacc ggttacaatt tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gatgggaaga atgaggtatg atggagacac atattataat      180

tcagttctca aatcccgact gagcatcagc agggacacct ccaagaacca agttttcttg      240

aaaatgaaca gtctgcaaac ggatgacaca gccatttact attgtaccag agacgggcgt      300

ggtgactcct ttgattactg gggccaagga gtcatggtca cagtctcctc cgccagcact      360

aaggggccct ctgtgtttcc actcgcccct tctagcaaaa gcacttccgg aggaactgcc      420

gctctgggct gtctggtgaa agattacttc cccgaaccag tcactgtgtc atggaactct      480

ggagcactga catctggagt tcacaccttt cctgctgtgc tgcagagttc tggactgtac      540

tccctgtcat ctgtggtcac cgtgccatct tcatctctgg ggacccagac ctacatctgt      600

aacgtgaacc acaaaccctc caacacaaaa gtcgacaaac gagtcgaacc aaaatcttgt      660

gacaaaactc acacatgccc accgtgccca gctccggaac tcctgggcgg accgtcagtc      720

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      780

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      960

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat gtcgggatga gctgaccaag     1080

aaccaggtca gcctgtggtg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gttggactcc     1200

gacggctcct tcttcctcta cagcgcgctc accgtggaca agagcaggtg gcagcagggg     1260

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc     1320

ctctccctgt ctccgggtaa a                                               1341


<210>  18
<211>  1413
<212>  DNA
<213>  ˹
<400>  18
gatattgtga tgacgcaggc tgcactcccc aatcctgtcc cttctggaga gtcagcttcc       60

atcacctgca ggtctagtca gagtctggta tacaaagacg gccagacata cttgaattgg      120

tttctgcaga ggccaggaca gtctcctcag cttctgacct attggatgtc tacccgtgca      180

tcaggagtct cagacaggtt cagtggcagt gggtcaggaa catatttcac actgaaaatc      240

agtagagtga gggctgagga tgcgggtgtg tattactgtc agcaagttcg agagtatcct      300

ttcactttcg gctcagggac gaagttggaa ataaaaggcg gcggcggcag cggcggcggc      360

ggcagcggcg gcggcggcag ccaggtgcag ctgaaggagt caggacctgg tctggtgcag      420

ccctcacaga ccctgtccct cacctgcact gtctctgggt tctcactaac cggttacaat      480

ttacactggg ttcgccagcc tccaggaaag ggtctggagt ggatgggaag aatgaggtat      540

gatggagaca catattataa ttcagttctc aaatcccgac tgagcatcag cagggacacc      600

tccaagaacc aagttttctt gaaaatgaac agtctgcaaa cggatgacac agccatttac      660

tattgtacca gagacgggcg tggtgactcc tttgattact ggggccaagg agtcatggtc      720

acagtctcct ccgacaaaac tcacacatgc ccaccgtgcc cagctccgga actcctgggc      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atgtcgggat     1140

gagctgacca agaaccaggt cagcctgtgg tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgttggact ccgacggctc cttcttcctc tacagcgcgc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaa                                  1413


<210>  19
<211>  1917
<212>  DNA
<213>  ˹
<400>  19
gatattgtga tgacgcaggc tgcactcccc aatcctgtcc cttctggaga gtcagcttcc       60

atcacctgca ggtctagtca gagtctggta tacaaagacg gccagacata cttgaattgg      120

tttctgcaga ggccaggaca gtctcctcag cttctgacct attggatgtc tacccgtgca      180

tcaggagtct cagacaggtt cagtggcagt gggtcaggaa catatttcac actgaaaatc      240

agtagagtga gggctgagga tgcgggtgtg tattactgtc agcaagttcg agagtatcct      300

ttcactttcg gctcagggac gaagttggaa ataaaaggcg gcggcggcag cggcggcggc      360

ggcagcggcg gcggcggcag ccaggtgcag ctgaaggagt caggacctgg tctggtgcag      420

ccctcacaga ccctgtccct cacctgcact gtctctgggt tctcactaac cggttacaat      480

ttacactggg ttcgccagcc tccaggaaag ggtctggagt ggatgggaag aatgaggtat      540

gatggagaca catattataa ttcagttctc aaatcccgac tgagcatcag cagggacacc      600

tccaagaacc aagttttctt gaaaatgaac agtctgcaaa cggatgacac agccatttac      660

tattgtacca gagacgggcg tggtgactcc tttgattact ggggccaagg agtcatggtc      720

acagtctcct ccgacaaaac ccacacatgc ccaccttgtc ccgcccctga actcctgggc      780

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      840

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      900

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac      960

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1020

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1080

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1140

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1200

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1260

gtgttggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1320

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1380

acgcagaaga gcctctccct gtctccgggt aaaggcggcg gcggcagcgg cggcggcggc     1440

agcggcggcg gcggcagcat gtacaggatg caactcctgt cttgcattgc actaagtctt     1500

gcacttgtca caaacagtgc acctacttca agttctacaa agaaaacaca gctacaactg     1560

gagcatttac tgctggattt acagatgatt ttgaatggaa ttaataatta caagaatccc     1620

aaactcacca ggatgctcac atttaagttt tacatgccca agaaggccac agaactgaaa     1680

catcttcagt gtctagaaga agaactcaaa cctctggagg aagtgctaaa tttagctcaa     1740

agcaaaaact ttcacttaag acccagggac ttaatcagca atatcaacgt aatagttctg     1800

gaactaaagg gatctgaaac aacattcatg tgtgaatatg ctgatgagac agcaaccatt     1860

gtagaatttc tgaacagatg gattaccttt tgtcaaagca tcatctcaac actgact        1917


<210>  20
<211>  1917
<212>  DNA
<213>  ˹
<400>  20
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gcggcggcgg cagcggcggc      480

ggcggcagcg gcggcggcgg cagcgatatt gtgatgacgc aggctgcact ccccaatcct      540

gtcccttctg gagagtcagc ttccatcacc tgcaggtcta gtcagagtct ggtatacaaa      600

gacggccaga catacttgaa ttggtttctg cagaggccag gacagtctcc tcagcttctg      660

acctattgga tgtctacccg tgcatcagga gtctcagaca ggttcagtgg cagtgggtca      720

ggaacatatt tcacactgaa aatcagtaga gtgagggctg aggatgcggg tgtgtattac      780

tgtcagcaag ttcgagagta tcctttcact ttcggctcag ggacgaagtt ggaaataaaa      840

ggcggcggcg gcagcggcgg cggcggcagc ggcggcggcg gcagccaggt gcagctgaag      900

gagtcaggac ctggtctggt gcagccctca cagaccctgt ccctcacctg cactgtctct      960

gggttctcac taaccggtta caatttacac tgggttcgcc agcctccagg aaagggtctg     1020

gagtggatgg gaagaatgag gtatgatgga gacacatatt ataattcagt tctcaaatcc     1080

cgactgagca tcagcaggga cacctccaag aaccaagttt tcttgaaaat gaacagtctg     1140

caaacggatg acacagccat ttactattgt accagagacg ggcgtggtga ctcctttgat     1200

tactggggcc aaggagtcat ggtcacagtc tcctccgaca aaacccacac atgcccacct     1260

tgtcccgccc ctgaactcct gggcggaccg tcagtcttcc tcttcccccc aaaacccaag     1320

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac     1380

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1440

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1500

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc     1560

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1620

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1680

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1740

aacaactaca agaccacgcc tcccgtgttg gactccgacg gctccttctt cctctacagc     1800

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1860

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa        1917


<210>  21
<211>  218
<212>  PRT
<213>  ˹
<400>  21
Asp Val Met Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Asn Tyr Leu Asn Trp Tyr Met Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Arg His Thr Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Asp Glu Asp Gln Ala Phe Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Trp Tyr Asp Tyr Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  22
<211>  219
<212>  PRT
<213>  ˹
<400>  22
Gln Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ser Val Thr Gly Thr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp Asn Trp Ile Arg Gln Phe Pro Gly Gln Lys Val Glu Trp 
        35                  40                  45              


Met Gly Phe Ile Tyr Tyr Glu Gly Ser Thr Tyr Tyr Asn Pro Ser Ile 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Val Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 


<210>  23
<211>  244
<212>  PRT
<213>  ˹
<400>  23
Asp Val Met Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Asn Tyr Leu Asn Trp Tyr Met Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Arg His Thr Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Asp Glu Asp Gln Ala Phe Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Trp Tyr Asp Tyr Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gly 
    130                 135                 140                 


Ser Leu Ser Leu Ser Cys Ser Val Thr Gly Thr Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Gly Trp Asn Trp Ile Arg Gln Phe Pro Gly Gln Lys Val Glu Trp 
                165                 170                 175     


Met Gly Phe Ile Tyr Tyr Glu Gly Ser Thr Tyr Tyr Asn Pro Ser Ile 
            180                 185                 190         


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
        195                 200                 205             


Leu Gln Val Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Gln Thr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  24
<211>  446
<212>  PRT
<213>  ˹
<400>  24
Gln Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ser Val Thr Gly Thr Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Gly Trp Asn Trp Ile Arg Gln Phe Pro Gly Gln Lys Val Glu Trp 
        35                  40                  45              


Met Gly Phe Ile Tyr Tyr Glu Gly Ser Thr Tyr Tyr Asn Pro Ser Ile 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Val Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Thr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  25
<211>  471
<212>  PRT
<213>  ˹
<400>  25
Asp Val Met Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Asn Tyr Leu Asn Trp Tyr Met Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Arg His Thr Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Asp Glu Asp Gln Ala Phe Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Trp Tyr Asp Tyr Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gly 
    130                 135                 140                 


Ser Leu Ser Leu Ser Cys Ser Val Thr Gly Thr Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Gly Trp Asn Trp Ile Arg Gln Phe Pro Gly Gln Lys Val Glu Trp 
                165                 170                 175     


Met Gly Phe Ile Tyr Tyr Glu Gly Ser Thr Tyr Tyr Asn Pro Ser Ile 
            180                 185                 190         


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
        195                 200                 205             


Leu Gln Val Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Gln Thr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
225                 230                 235                 240 


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Ala Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  26
<211>  619
<212>  PRT
<213>  ˹
<400>  26
Asp Val Met Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser Leu Phe Asn Ser 
            20                  25                  30          


Asn Ala Lys Thr Asn Tyr Leu Asn Trp Tyr Met Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Arg His Thr Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Asp Glu Asp Gln Ala Phe Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Trp Tyr Asp Tyr Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Asn Pro Ser Gly 
    130                 135                 140                 


Ser Leu Ser Leu Ser Cys Ser Val Thr Gly Thr Ser Ile Thr Ser Gly 
145                 150                 155                 160 


Tyr Gly Trp Asn Trp Ile Arg Gln Phe Pro Gly Gln Lys Val Glu Trp 
                165                 170                 175     


Met Gly Phe Ile Tyr Tyr Glu Gly Ser Thr Tyr Tyr Asn Pro Ser Ile 
            180                 185                 190         


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
        195                 200                 205             


Leu Gln Val Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Ala Arg Gln Thr Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
225                 230                 235                 240 


Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr 
                485                 490                 495     


Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn 
            500                 505                 510         


Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe 
        515                 520                 525             


Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys 
    530                 535                 540                 


Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln 
545                 550                 555                 560 


Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn 
                565                 570                 575     


Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu 
            580                 585                 590         


Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile 
        595                 600                 605             


Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
    610                 615                 


<210>  27
<211>  619
<212>  PRT
<213>  ˹
<400>  27
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Val Met Met Thr Gln Ser Pro Ser Ser Leu Ser 
145                 150                 155                 160 


Val Ser Ala Gly Glu Lys Ala Thr Ile Ser Cys Lys Ser Ser Gln Ser 
                165                 170                 175     


Leu Phe Asn Ser Asn Ala Lys Thr Asn Tyr Leu Asn Trp Tyr Met Gln 
            180                 185                 190         


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Thr Arg 
        195                 200                 205             


His Thr Gly Val Pro Asp Arg Phe Arg Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Phe Thr Leu Thr Ile Ser Ser Val Gln Asp Glu Asp Gln Ala Phe Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Trp Tyr Asp Tyr Pro Tyr Thr Phe Gly Ala Gly Thr 
                245                 250                 255     


Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gln Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val 
        275                 280                 285             


Asn Pro Ser Gly Ser Leu Ser Leu Ser Cys Ser Val Thr Gly Thr Ser 
    290                 295                 300                 


Ile Thr Ser Gly Tyr Gly Trp Asn Trp Ile Arg Gln Phe Pro Gly Gln 
305                 310                 315                 320 


Lys Val Glu Trp Met Gly Phe Ile Tyr Tyr Glu Gly Ser Thr Tyr Tyr 
                325                 330                 335     


Asn Pro Ser Ile Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys 
            340                 345                 350         


Asn Gln Phe Phe Leu Gln Val Asn Ser Val Thr Thr Glu Asp Thr Ala 
        355                 360                 365             


Thr Tyr Tyr Cys Ala Arg Gln Thr Gly Tyr Phe Asp Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Met Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
385                 390                 395                 400 


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                405                 410                 415     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            420                 425                 430         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        435                 440                 445             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    450                 455                 460                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
465                 470                 475                 480 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                485                 490                 495     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            500                 505                 510         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        515                 520                 525             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    530                 535                 540                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
545                 550                 555                 560 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                565                 570                 575     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            580                 585                 590         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        595                 600                 605             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 


<210>  28
<211>  214
<212>  PRT
<213>  ˹
<400>  28
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ser Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Ser Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Ile Gly Ile Tyr Tyr Cys Leu Gln Ala Tyr Gly Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  29
<211>  213
<212>  PRT
<213>  ˹
<400>  29
Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Arg Thr Ser Gln Asn Val Tyr Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Ala Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Ser Gly Asn Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Asn Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  30
<211>  223
<212>  PRT
<213>  ˹
<400>  30
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Tyr Phe 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Asp Gly Ser Ile Pro Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Glu Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Gly Gly Tyr Ser Glu Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220             


<210>  31
<211>  227
<212>  PRT
<213>  ˹
<400>  31
Glu Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Gly Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Gly Val Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Ala Gly Gly Thr Thr Tyr Tyr Arg Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Asp Gly Tyr Gly Gly Tyr Ser Gly Ser His Trp Tyr Phe Asp 
            100                 105                 110         


Phe Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys 
225         


<210>  32
<211>  242
<212>  PRT
<213>  ˹
<400>  32
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ser Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Ser Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Ile Gly Ile Tyr Tyr Cys Leu Gln Ala Tyr Gly Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Ile Phe Ser Tyr Phe Asp Met Ala Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Thr Lys Gly Leu Glu Trp Val Ala Ser Ile Ser Pro Asp 
                165                 170                 175     


Gly Ser Ile Pro Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Val 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Ser Tyr Gly 
    210                 215                 220                 


Gly Tyr Ser Glu Leu Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  33
<211>  245
<212>  PRT
<213>  ˹
<400>  33
Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Arg Thr Ser Gln Asn Val Tyr Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Ala Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Ser Gly Asn Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Asn Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Met Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Met Lys Leu Ser Cys Ala 
    130                 135                 140                 


Gly Ser Gly Phe Thr Ile Ser Asp Tyr Gly Val Ala Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Lys Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Tyr Ala Gly 
                165                 170                 175     


Gly Thr Thr Tyr Tyr Arg Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg 
        195                 200                 205             


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Ile Asp Gly Tyr Gly Gly 
    210                 215                 220                 


Tyr Ser Gly Ser His Trp Tyr Phe Asp Phe Trp Gly Pro Gly Thr Met 
225                 230                 235                 240 


Val Thr Val Ser Ser 
                245 


<210>  34
<211>  450
<212>  PRT
<213>  ˹
<400>  34
Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Tyr Phe 
            20                  25                  30          


Asp Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Pro Asp Gly Ser Ile Pro Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Val Ser Arg Glu Asn Ala Lys Ser Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Tyr Gly Gly Tyr Ser Glu Leu Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Val Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  35
<211>  454
<212>  PRT
<213>  ˹
<400>  35
Glu Met Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Gly Ser Gly Phe Thr Ile Ser Asp Tyr 
            20                  25                  30          


Gly Val Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Tyr Ala Gly Gly Thr Thr Tyr Tyr Arg Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Asp Gly Tyr Gly Gly Tyr Ser Gly Ser His Trp Tyr Phe Asp 
            100                 105                 110         


Phe Trp Gly Pro Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  36
<211>  469
<212>  PRT
<213>  ˹
<400>  36
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ser Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Ser Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Ile Gly Ile Tyr Tyr Cys Leu Gln Ala Tyr Gly Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Ile Phe Ser Tyr Phe Asp Met Ala Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Thr Lys Gly Leu Glu Trp Val Ala Ser Ile Ser Pro Asp 
                165                 170                 175     


Gly Ser Ile Pro Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Val 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Ser Tyr Gly 
    210                 215                 220                 


Gly Tyr Ser Glu Leu Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Ala Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  37
<211>  472
<212>  PRT
<213>  ˹
<400>  37
Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Arg Thr Ser Gln Asn Val Tyr Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Ala Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Ser Gly Asn Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Asn Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Met Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Met Lys Leu Ser Cys Ala 
    130                 135                 140                 


Gly Ser Gly Phe Thr Ile Ser Asp Tyr Gly Val Ala Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Lys Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Tyr Ala Gly 
                165                 170                 175     


Gly Thr Thr Tyr Tyr Arg Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg 
        195                 200                 205             


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Ile Asp Gly Tyr Gly Gly 
    210                 215                 220                 


Tyr Ser Gly Ser His Trp Tyr Phe Asp Phe Trp Gly Pro Gly Thr Met 
225                 230                 235                 240 


Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Ala Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  38
<211>  617
<212>  PRT
<213>  ˹
<400>  38
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Leu Glu 
1               5                   10                  15      


Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Gly Asn Trp 
            20                  25                  30          


Leu Ala Trp Tyr His Gln Lys Pro Gly Lys Ser Pro Gln Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ser Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Ser Ser Gly Ser Gln Tyr Ser Leu Lys Ile Ser Arg Leu Gln Val 
65                  70                  75                  80  


Glu Asp Ile Gly Ile Tyr Tyr Cys Leu Gln Ala Tyr Gly Ala Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu Lys Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Ile Phe Ser Tyr Phe Asp Met Ala Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Thr Lys Gly Leu Glu Trp Val Ala Ser Ile Ser Pro Asp 
                165                 170                 175     


Gly Ser Ile Pro Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Val 
            180                 185                 190         


Ser Arg Glu Asn Ala Lys Ser Ser Leu Tyr Leu Gln Met Asp Ser Leu 
        195                 200                 205             


Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Arg Ser Tyr Gly 
    210                 215                 220                 


Gly Tyr Ser Glu Leu Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val 
225                 230                 235                 240 


Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
                485                 490                 495     


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
            500                 505                 510         


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
        515                 520                 525             


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
    530                 535                 540                 


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
545                 550                 555                 560 


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
                565                 570                 575     


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
            580                 585                 590         


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
        595                 600                 605             


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
    610                 615         


<210>  39
<211>  620
<212>  PRT
<213>  ˹
<400>  39
Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Leu Asn Cys Arg Thr Ser Gln Asn Val Tyr Lys Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Gln Leu Gly Glu Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Ala Asn Ser Leu Gln Ala Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr Ser Gly Asn Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Asn Leu Glu Leu Lys Gly Gly Gly Gly Ser Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Met Gln Leu Val Glu Ser 
        115                 120                 125             


Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Met Lys Leu Ser Cys Ala 
    130                 135                 140                 


Gly Ser Gly Phe Thr Ile Ser Asp Tyr Gly Val Ala Trp Val Arg Gln 
145                 150                 155                 160 


Ala Pro Lys Lys Gly Leu Glu Trp Val Ala Tyr Ile Ser Tyr Ala Gly 
                165                 170                 175     


Gly Thr Thr Tyr Tyr Arg Glu Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln Met Asp Ser Leu Arg 
        195                 200                 205             


Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Ile Asp Gly Tyr Gly Gly 
    210                 215                 220                 


Tyr Ser Gly Ser His Trp Tyr Phe Asp Phe Trp Gly Pro Gly Thr Met 
225                 230                 235                 240 


Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly 
465                 470                 475                 480 


Gly Ser Gly Gly Gly Gly Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys 
                485                 490                 495     


Thr Gln Leu Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu 
            500                 505                 510         


Asn Gly Ile Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr 
        515                 520                 525             


Phe Lys Phe Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln 
    530                 535                 540                 


Cys Leu Glu Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala 
545                 550                 555                 560 


Gln Ser Lys Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile 
                565                 570                 575     


Asn Val Ile Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys 
            580                 585                 590         


Glu Tyr Ala Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp 
        595                 600                 605             


Ile Thr Phe Cys Gln Ser Ile Ile Ser Thr Leu Thr 
    610                 615                 620 


<210>  40
<211>  617
<212>  PRT
<213>  ˹
<400>  40
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser 
145                 150                 155                 160 


Ala Ser Leu Glu Glu Ile Val Thr Ile Thr Cys Gln Ala Ser Gln Asp 
                165                 170                 175     


Ile Gly Asn Trp Leu Ala Trp Tyr His Gln Lys Pro Gly Lys Ser Pro 
            180                 185                 190         


Gln Leu Leu Ile Tyr Gly Ser Thr Ser Leu Ala Asp Gly Val Pro Ser 
        195                 200                 205             


Arg Phe Ser Gly Ser Ser Ser Gly Ser Gln Tyr Ser Leu Lys Ile Ser 
    210                 215                 220                 


Arg Leu Gln Val Glu Asp Ile Gly Ile Tyr Tyr Cys Leu Gln Ala Tyr 
225                 230                 235                 240 


Gly Ala Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Leu 
        275                 280                 285             


Lys Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Tyr Phe Asp Met 
    290                 295                 300                 


Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val Ala Ser 
305                 310                 315                 320 


Ile Ser Pro Asp Gly Ser Ile Pro Tyr Tyr Arg Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Val Ser Arg Glu Asn Ala Lys Ser Ser Leu Tyr Leu Gln 
            340                 345                 350         


Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Ala Arg 
        355                 360                 365             


Arg Ser Tyr Gly Gly Tyr Ser Glu Leu Asp Tyr Trp Gly Gln Gly Val 
    370                 375                 380                 


Met Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                405                 410                 415     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            420                 425                 430         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        435                 440                 445             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    450                 455                 460                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
465                 470                 475                 480 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                485                 490                 495     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            500                 505                 510         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        515                 520                 525             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    530                 535                 540                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
545                 550                 555                 560 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                565                 570                 575     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            580                 585                 590         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        595                 600                 605             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615         


<210>  41
<211>  620
<212>  PRT
<213>  ˹
<400>  41
Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Leu Leu Ser 
145                 150                 155                 160 


Ala Ser Val Gly Asp Arg Val Thr Leu Asn Cys Arg Thr Ser Gln Asn 
                165                 170                 175     


Val Tyr Lys Asn Leu Ala Trp Tyr Gln Gln Gln Leu Gly Glu Ala Pro 
            180                 185                 190         


Lys Leu Leu Ile Tyr Asn Ala Asn Ser Leu Gln Ala Gly Ile Pro Ser 
        195                 200                 205             


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
    210                 215                 220                 


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Tyr Tyr 
225                 230                 235                 240 


Ser Gly Asn Thr Phe Gly Ala Gly Thr Asn Leu Glu Leu Lys Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Met Gln 
            260                 265                 270         


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg Ser Met Lys 
        275                 280                 285             


Leu Ser Cys Ala Gly Ser Gly Phe Thr Ile Ser Asp Tyr Gly Val Ala 
    290                 295                 300                 


Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val Ala Tyr Ile 
305                 310                 315                 320 


Ser Tyr Ala Gly Gly Thr Thr Tyr Tyr Arg Glu Ser Val Lys Gly Arg 
                325                 330                 335     


Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln Met 
            340                 345                 350         


Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys Thr Ile Asp 
        355                 360                 365             


Gly Tyr Gly Gly Tyr Ser Gly Ser His Trp Tyr Phe Asp Phe Trp Gly 
    370                 375                 380                 


Pro Gly Thr Met Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro 
385                 390                 395                 400 


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
                405                 410                 415     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            420                 425                 430         


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        435                 440                 445             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    450                 455                 460                 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
465                 470                 475                 480 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                485                 490                 495     


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            500                 505                 510         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        515                 520                 525             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    530                 535                 540                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
545                 550                 555                 560 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                565                 570                 575     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            580                 585                 590         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        595                 600                 605             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    610                 615                 620 


<210>  42
<211>  642
<212>  DNA
<213>  ˹
<400>  42
gacatccaga tgacccagag ccccgcctct ctgagcgctt ctctggagga gatcgtgacc       60

atcacatgcc aagccagcca agacatcggc aactggctgg cttggtatca ccagaagccc      120

ggcaagagcc cccagctgct gatctacggc agcacatctc tggctgatgg cgtgccctcc      180

agatttagcg gcagcagcag cggaagccag tactctctga agatctctag actgcaagtg      240

gaggacattg gcatctacta ctgtctgcaa gcctatggcg ccccttggac attcggaggc      300

ggcacaaagc tggagctgaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggtaccgct agcgttgtgt gcctgctgaa taacttttat      420

ccacgggagg ctaaggtgca gtggaaagtg gacaatgccc tccagagcgg aaatagccaa      480

gagtccgtta ccgaacagga ctctaaagac tctacatact ccctgtcctc cacactgacc      540

ctctccaagg ccgactatga gaaacacaag gtttacgcat gcgaggtcac acaccaggga      600

ctctcctctc ccgtgaccaa gagcttcaac cggggagaat gc                         642


<210>  43
<211>  639
<212>  DNA
<213>  ˹
<400>  43
gacatccaga tgacccagag cccttctctg ctgagcgctt ccgtgggaga cagagtgaca       60

ctgaactgta gaacctccca gaacgtgtac aagaatctgg cttggtatca gcagcagctg      120

ggcgaagccc ccaagctgct gatctacaac gccaactctc tgcaagccgg catccctagc      180

agattcagcg gctccggcag cggaaccgac tttacactga ccatcagctc tctgcagccc      240

gaggatgtgg ccacctactt ctgccagcag tactacagcg gcaacacctt cggcgccggc      300

accaatctgg agctgaagcg tacggtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg taccgctagc gttgtgtgcc tgctgaataa cttttatcca      420

cgggaggcta aggtgcagtg gaaagtggac aatgccctcc agagcggaaa tagccaagag      480

tccgttaccg aacaggactc taaagactct acatactccc tgtcctccac actgaccctc      540

tccaaggccg actatgagaa acacaaggtt tacgcatgcg aggtcacaca ccagggactc      600

tcctctcccg tgaccaagag cttcaaccgg ggagaatgc                             639


<210>  44
<211>  1350
<212>  DNA
<213>  ˹
<400>  44
gacgtgcagc tggtggaatc cggcggagga ctggtgcagc ccggcagatc tctgaaactc       60

agctgcgccg ccagcggctt catcttcagc tacttcgaca tggcttgggt gagacaagcc      120

cctaccaaag gactggagtg ggtggccagc attagccccg acggcagcat tccctactat      180

agagacagcg tgaagggaag attcaccgtg agcagagaga acgccaagag ctctctgtat      240

ctgcagatgg actctctgag aagcgaggac accgccacct actactgcgc cagaagaagc      300

tacggcggct acagcgagct ggactactgg ggacaaggcg tgatggtgac agtgagcagc      360

gccagcacta aggggccctc tgtgtttcca ctcgcccctt ctagcaaaag cacttccgga      420

ggaactgccg ctctgggctg tctggtgaaa gattacttcc ccgaaccagt cactgtgtca      480

tggaactctg gagcactgac atctggagtt cacacctttc ctgctgtgct gcagagttct      540

ggactgtact ccctgtcatc tgtggtcacc gtgccatctt catctctggg gacccagacc      600

tacatctgta acgtgaacca caaaccctcc aacacaaaag tcgacaaacg agtcgaacca      660

aaatcttgtg acaaaactca cacatgccca ccgtgcccag ctccggaact cctgggcgga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatg tcgggatgag     1080

ctgaccaaga accaggtcag cctgtggtgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ttggactccg acggctcctt cttcctctac agcgcgctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa                                      1350


<210>  45
<211>  1362
<212>  DNA
<213>  ˹
<400>  45
gagatgcagc tggtggagag cggaggagga ctggtgcagc ccggcagaag catgaagctg       60

agctgtgccg gcagcggctt caccatcagc gattacggcg tggcttgggt gagacaagcc      120

cctaagaagg gactggagtg ggtggcctac atcagctacg ccggcggcac cacctactac      180

agagagagcg tgaagggaag attcaccatt tctagagaca acgccaagag cacactgtat      240

ctgcagatgg actctctgag gagcgaggac accgccacct actactgcac catcgacggc      300

tatggcggct acagcggcag ccactggtac ttcgacttct ggggacccgg caccatggtg      360

accgtgagca gcgccagcac taaggggccc tctgtgtttc cactcgcccc ttctagcaaa      420

agcacttccg gaggaactgc cgctctgggc tgtctggtga aagattactt ccccgaacca      480

gtcactgtgt catggaactc tggagcactg acatctggag ttcacacctt tcctgctgtg      540

ctgcagagtt ctggactgta ctccctgtca tctgtggtca ccgtgccatc ttcatctctg      600

gggacccaga cctacatctg taacgtgaac cacaaaccct ccaacacaaa agtcgacaaa      660

cgagtcgaac caaaatcttg tgacaaaact cacacatgcc caccgtgccc agctccggaa      720

ctcctgggcg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tgtcgggatg agctgaccaa gaaccaggtc agcctgtggt gcctggtcaa aggcttctat     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acgcctcccg tgttggactc cgacggctcc ttcttcctct acagcgcgct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  46
<211>  1407
<212>  DNA
<213>  ˹
<400>  46
gacatccaga tgacccagag ccccgcctct ctgagcgctt ctctggagga gatcgtgacc       60

atcacatgcc aagccagcca agacatcggc aactggctgg cttggtatca ccagaagccc      120

ggcaagagcc cccagctgct gatctacggc agcacatctc tggctgatgg cgtgccctcc      180

agatttagcg gcagcagcag cggaagccag tactctctga agatctctag actgcaagtg      240

gaggacattg gcatctacta ctgtctgcaa gcctatggcg ccccttggac attcggaggc      300

ggcacaaagc tggagctgaa gggcggcggc ggcagcggcg gcggcggcag cggcggcggc      360

ggcagcgacg tgcagctggt ggaatccggc ggaggactgg tgcagcccgg cagatctctg      420

aaactcagct gcgccgccag cggcttcatc ttcagctact tcgacatggc ttgggtgaga      480

caagccccta ccaaaggact ggagtgggtg gccagcatta gccccgacgg cagcattccc      540

tactatagag acagcgtgaa gggaagattc accgtgagca gagagaacgc caagagctct      600

ctgtatctgc agatggactc tctgagaagc gaggacaccg ccacctacta ctgcgccaga      660

agaagctacg gcggctacag cgagctggac tactggggac aaggcgtgat ggtgacagtg      720

agcagcgaca aaactcacac atgcccaccg tgcccagctc cggaactcct gggcggaccg      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatgtcg ggatgagctg     1140

accaagaacc aggtcagcct gtggtgcctg gtcaaaggct tctatcccag cgacatcgcc     1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgttg     1260

gactccgacg gctccttctt cctctacagc gcgctcaccg tggacaagag caggtggcag     1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1380

aagagcctct ccctgtctcc gggtaaa                                         1407


<210>  47
<211>  1416
<212>  DNA
<213>  ˹
<400>  47
gacatccaga tgacccagag cccttctctg ctgagcgctt ccgtgggaga cagagtgaca       60

ctgaactgta gaacctccca gaacgtgtac aagaatctgg cttggtatca gcagcagctg      120

ggcgaagccc ccaagctgct gatctacaac gccaactctc tgcaagccgg catccctagc      180

agattcagcg gctccggcag cggaaccgac tttacactga ccatcagctc tctgcagccc      240

gaggatgtgg ccacctactt ctgccagcag tactacagcg gcaacacctt cggcgccggc      300

accaatctgg agctgaaggg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      360

agcgagatgc agctggtgga gagcggagga ggactggtgc agcccggcag aagcatgaag      420

ctgagctgtg ccggcagcgg cttcaccatc agcgattacg gcgtggcttg ggtgagacaa      480

gcccctaaga agggactgga gtgggtggcc tacatcagct acgccggcgg caccacctac      540

tacagagaga gcgtgaaggg aagattcacc atttctagag acaacgccaa gagcacactg      600

tatctgcaga tggactctct gaggagcgag gacaccgcca cctactactg caccatcgac      660

ggctatggcg gctacagcgg cagccactgg tacttcgact tctggggacc cggcaccatg      720

gtgaccgtga gcagcgacaa aactcacaca tgcccaccgt gcccagctcc ggaactcctg      780

ggcggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatgtcgg     1140

gatgagctga ccaagaacca ggtcagcctg tggtgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgttgg actccgacgg ctccttcttc ctctacagcg cgctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaa                               1416


<210>  48
<211>  1911
<212>  DNA
<213>  ˹
<400>  48
gacatccaga tgacccagag ccccgcctct ctgagcgctt ctctggagga gatcgtgacc       60

atcacatgcc aagccagcca agacatcggc aactggctgg cttggtatca ccagaagccc      120

ggcaagagcc cccagctgct gatctacggc agcacatctc tggctgatgg cgtgccctcc      180

agatttagcg gcagcagcag cggaagccag tactctctga agatctctag actgcaagtg      240

gaggacattg gcatctacta ctgtctgcaa gcctatggcg ccccttggac attcggaggc      300

ggcacaaagc tggagctgaa gggcggcggc ggcagcggcg gcggcggcag cggcggcggc      360

ggcagcgacg tgcagctggt ggaatccggc ggaggactgg tgcagcccgg cagatctctg      420

aaactcagct gcgccgccag cggcttcatc ttcagctact tcgacatggc ttgggtgaga      480

caagccccta ccaaaggact ggagtgggtg gccagcatta gccccgacgg cagcattccc      540

tactatagag acagcgtgaa gggaagattc accgtgagca gagagaacgc caagagctct      600

ctgtatctgc agatggactc tctgagaagc gaggacaccg ccacctacta ctgcgccaga      660

agaagctacg gcggctacag cgagctggac tactggggac aaggcgtgat ggtgacagtg      720

agcagcgaca aaacccacac atgcccacct tgtcccgccc ctgaactcct gggcggaccg      780

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      840

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      900

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      960

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag     1020

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1080

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggatgagctg     1140

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1200

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgttg     1260

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1320

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1380

aagagcctct ccctgtctcc gggtaaaggc ggcggcggca gcggcggcgg cggcagcggc     1440

ggcggcggca gcatgtacag gatgcaactc ctgtcttgca ttgcactaag tcttgcactt     1500

gtcacaaaca gtgcacctac ttcaagttct acaaagaaaa cacagctaca actggagcat     1560

ttactgctgg atttacagat gattttgaat ggaattaata attacaagaa tcccaaactc     1620

accaggatgc tcacatttaa gttttacatg cccaagaagg ccacagaact gaaacatctt     1680

cagtgtctag aagaagaact caaacctctg gaggaagtgc taaatttagc tcaaagcaaa     1740

aactttcact taagacccag ggacttaatc agcaatatca acgtaatagt tctggaacta     1800

aagggatctg aaacaacatt catgtgtgaa tatgctgatg agacagcaac cattgtagaa     1860

tttctgaaca gatggattac cttttgtcaa agcatcatct caacactgac t              1911


<210>  49
<211>  1920
<212>  DNA
<213>  ˹
<400>  49
gacatccaga tgacccagag cccttctctg ctgagcgctt ccgtgggaga cagagtgaca       60

ctgaactgta gaacctccca gaacgtgtac aagaatctgg cttggtatca gcagcagctg      120

ggcgaagccc ccaagctgct gatctacaac gccaactctc tgcaagccgg catccctagc      180

agattcagcg gctccggcag cggaaccgac tttacactga ccatcagctc tctgcagccc      240

gaggatgtgg ccacctactt ctgccagcag tactacagcg gcaacacctt cggcgccggc      300

accaatctgg agctgaaggg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc      360

agcgagatgc agctggtgga gagcggagga ggactggtgc agcccggcag aagcatgaag      420

ctgagctgtg ccggcagcgg cttcaccatc agcgattacg gcgtggcttg ggtgagacaa      480

gcccctaaga agggactgga gtgggtggcc tacatcagct acgccggcgg caccacctac      540

tacagagaga gcgtgaaggg aagattcacc atttctagag acaacgccaa gagcacactg      600

tatctgcaga tggactctct gaggagcgag gacaccgcca cctactactg caccatcgac      660

ggctatggcg gctacagcgg cagccactgg tacttcgact tctggggacc cggcaccatg      720

gtgaccgtga gcagcgacaa aacccacaca tgcccacctt gtcccgcccc tgaactcctg      780

ggcggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg      840

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc      900

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag      960

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1020

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1080

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1140

gatgagctga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1200

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1260

cccgtgttgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc     1320

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac     1380

tacacgcaga agagcctctc cctgtctccg ggtaaaggcg gcggcggcag cggcggcggc     1440

ggcagcggcg gcggcggcag catgtacagg atgcaactcc tgtcttgcat tgcactaagt     1500

cttgcacttg tcacaaacag tgcacctact tcaagttcta caaagaaaac acagctacaa     1560

ctggagcatt tactgctgga tttacagatg attttgaatg gaattaataa ttacaagaat     1620

cccaaactca ccaggatgct cacatttaag ttttacatgc ccaagaaggc cacagaactg     1680

aaacatcttc agtgtctaga agaagaactc aaacctctgg aggaagtgct aaatttagct     1740

caaagcaaaa actttcactt aagacccagg gacttaatca gcaatatcaa cgtaatagtt     1800

ctggaactaa agggatctga aacaacattc atgtgtgaat atgctgatga gacagcaacc     1860

attgtagaat ttctgaacag atggattacc ttttgtcaaa gcatcatctc aacactgact     1920


<210>  50
<211>  1911
<212>  DNA
<213>  ˹
<400>  50
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gcggcggcgg cagcggcggc      480

ggcggcagcg gcggcggcgg cagcgacatc cagatgaccc agagccccgc ctctctgagc      540

gcttctctgg aggagatcgt gaccatcaca tgccaagcca gccaagacat cggcaactgg      600

ctggcttggt atcaccagaa gcccggcaag agcccccagc tgctgatcta cggcagcaca      660

tctctggctg atggcgtgcc ctccagattt agcggcagca gcagcggaag ccagtactct      720

ctgaagatct ctagactgca agtggaggac attggcatct actactgtct gcaagcctat      780

ggcgcccctt ggacattcgg aggcggcaca aagctggagc tgaagggcgg cggcggcagc      840

ggcggcggcg gcagcggcgg cggcggcagc gacgtgcagc tggtggaatc cggcggagga      900

ctggtgcagc ccggcagatc tctgaaactc agctgcgccg ccagcggctt catcttcagc      960

tacttcgaca tggcttgggt gagacaagcc cctaccaaag gactggagtg ggtggccagc     1020

attagccccg acggcagcat tccctactat agagacagcg tgaagggaag attcaccgtg     1080

agcagagaga acgccaagag ctctctgtat ctgcagatgg actctctgag aagcgaggac     1140

accgccacct actactgcgc cagaagaagc tacggcggct acagcgagct ggactactgg     1200

ggacaaggcg tgatggtgac agtgagcagc gacaaaaccc acacatgccc accttgtccc     1260

gcccctgaac tcctgggcgg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc     1320

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac     1380

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag     1440

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1500

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc     1560

cccatcgaga aaaccatctc caaagccaaa gggcagcccc gagaaccaca ggtgtacacc     1620

ctgcccccat cccgggatga gctgaccaag aaccaggtca gcctgacctg cctggtcaaa     1680

ggcttctatc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1740

tacaagacca cgcctcccgt gttggactcc gacggctcct tcttcctcta cagcaagctc     1800

accgtggaca agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag     1860

gctctgcaca accactacac gcagaagagc ctctccctgt ctccgggtaa a              1911


<210>  51
<211>  1920
<212>  DNA
<213>  ˹
<400>  51
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactg gcggcggcgg cagcggcggc      480

ggcggcagcg gcggcggcgg cagcgacatc cagatgaccc agagcccttc tctgctgagc      540

gcttccgtgg gagacagagt gacactgaac tgtagaacct cccagaacgt gtacaagaat      600

ctggcttggt atcagcagca gctgggcgaa gcccccaagc tgctgatcta caacgccaac      660

tctctgcaag ccggcatccc tagcagattc agcggctccg gcagcggaac cgactttaca      720

ctgaccatca gctctctgca gcccgaggat gtggccacct acttctgcca gcagtactac      780

agcggcaaca ccttcggcgc cggcaccaat ctggagctga agggcggcgg cggcagcggc      840

ggcggcggca gcggcggcgg cggcagcgag atgcagctgg tggagagcgg aggaggactg      900

gtgcagcccg gcagaagcat gaagctgagc tgtgccggca gcggcttcac catcagcgat      960

tacggcgtgg cttgggtgag acaagcccct aagaagggac tggagtgggt ggcctacatc     1020

agctacgccg gcggcaccac ctactacaga gagagcgtga agggaagatt caccatttct     1080

agagacaacg ccaagagcac actgtatctg cagatggact ctctgaggag cgaggacacc     1140

gccacctact actgcaccat cgacggctat ggcggctaca gcggcagcca ctggtacttc     1200

gacttctggg gacccggcac catggtgacc gtgagcagcg acaaaaccca cacatgccca     1260

ccttgtcccg cccctgaact cctgggcgga ccgtcagtct tcctcttccc cccaaaaccc     1320

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1380

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1440

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1500

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1560

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1620

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc     1680

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1740

gagaacaact acaagaccac gcctcccgtg ttggactccg acggctcctt cttcctctac     1800

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     1860

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa     1920


<210>  52
<211>  108
<212>  PRT
<213>  ˹
<400>  52
Glu Ile Glu Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  53
<211>  120
<212>  PRT
<213>  ˹
<400>  53
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Met 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Asn Val Met Gly Leu Tyr Trp Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  54
<211>  107
<212>  PRT
<213>  ˹
<400>  54
Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Arg Thr Asp Tyr Ser Leu Thr Ile Thr Asp Leu Asp Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  55
<211>  121
<212>  PRT
<213>  ˹
<400>  55
Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Phe Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Arg Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn His Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Phe Cys Ala 
                85                  90                  95      


Arg Tyr Arg Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  56
<211>  128
<212>  PRT
<213>  ˹
<400>  56
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Leu Ser Arg Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
            20                  25                  30          


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ala Thr 
        35                  40                  45              


Ser Ser Ile Thr Tyr Met Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Trp 
            100                 105                 110         


Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


<210>  57
<211>  142
<212>  PRT
<213>  ˹
<400>  57
Met Ala Val Leu Val Leu Phe Leu Cys Leu Val Ala Phe Pro Ser Cys 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys 
            20                  25                  30          


Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Ser Tyr Gly Val Tyr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Val Ile Trp Ala Gly Gly Thr Thr Asn Tyr Asn Ser 
65                  70                  75                  80  


Ala Leu Met Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln 
                85                  90                  95      


Val Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Gly Pro Pro His Ala Met Met Lys Arg Gly Tyr Ala 
        115                 120                 125             


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140         


<210>  58
<211>  109
<212>  PRT
<213>  ˹
<400>  58
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 


<210>  59
<211>  120
<212>  PRT
<213>  ˹
<400>  59
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Thr 
1               5                   10                  15      


Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr Tyr 
            20                  25                  30          


Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu Ser 
    50                  55                  60                  


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
65                  70                  75                  80  


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  60
<211>  108
<212>  PRT
<213>  ˹
<400>  60
Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Asp Gln Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Lys Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Tyr Thr Gly Phe Gly Ser Leu 
                85                  90                  95      


Ala Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  61
<211>  116
<212>  PRT
<213>  ˹
<400>  61
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Lys Ile Tyr Pro Gly Asp Ser Tyr Thr Asn Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


