序列表 

<110>  南京北恒生物科技有限公司
       江苏浦珠生物医药科技有限公司
 
<120>  靶向BCMA的单域抗体及其用途

<130>  BHPCT15

<160>  123  

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR1

<400>  1
Gly Arg Ala Ile Ser Ser Ile
                5


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR2

<400>  2
Asn Arg Trp Gly Gly Thr
                5


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR3

<400>  3
Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr
                5                   10


<210>  4
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR1

<400>  4
Gly Gly Ile Phe Thr Ile Asn
                5


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR2

<400>  5
Ser Arg Ser Gly Ser
                5


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR3

<400>  6
Asp Arg Pro Leu Ser Tyr
                5                   


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CDR1

<400>  7
Gly Ile Thr Leu Ser Ser Tyr
                5                  


<210>  8
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR1

<400>  8
Gln Glu Val Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25
                

<210>  9
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR2

<400>  9
Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val 
                5                   10                  15

Ala Ser Ile

     
<210>  10
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR3

<400>  10
Pro Tyr Tyr Ser His Ser Val Lys Gly Arg Phe Thr Ile Thr Arg Asp 
                5                   10                  15

His Ala Lys Asn Thr Ile His Leu Gln Met Asn Asn Leu Lys Ser Ala
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Ala Ala
        35                  40


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR4

<400>  11
Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                5                   10


<210>  12
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR1

<400>  12
Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser
            20                  25
                

<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR2

<400>  13
Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
                5                   10                  15

Ala His Ile

     
<210>  14
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR3

<400>  14
Thr Tyr Tyr Arg Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asn 
                5                   10                  15

Asn Ala Lys Asn Thr Ser Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu
            20                  25                      30

Asp Thr Ala Thr Tyr Tyr Cys Asn Ser Ile
        35                  40


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR4

<400>  15
Gly Gln Gly Thr Gln Val Thr Val Ser
                5


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR4

<400>  16
Gly Gln Gly Thr Leu Val Thr Val Ser
                5


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR1

<400>  17
Gln Val His Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser
            20                  25
                

<210>  18
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR2

<400>  18
Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
                5                   10                  15

Ala His Ile

     
<210>  19
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR3

<400>  19
Tyr Tyr Arg Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asn Asn 
                5                   10                  15

Ala Lys Asn Thr Ser Tyr Leu Gln Met Asn Asn Leu Lys Pro Glu Asp
            20                  25                  30
        
Thr Ala Thr Tyr Tyr Cys Asn Ser Ile
        35                  40


<210>  20
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR1

<400>  20
Gln Glu Arg Leu Val Glu Ser Gly Gly Gly Ser Val His Ala Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Ala Ser
            20              25
               

<210>  21
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR3

<400>  21
Thr Tyr Tyr Ala Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Lys Asn 
                5                   10                  15

Asn Ala Lys Asn Thr Ser Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp
            20                  25                  30

Asp Thr Ala Thr Tyr Tyr Cys Asn Ser Ile
        35                  40


<210>  22
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR1

<400>  22
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly
                5                   10                  15
 
Ser Leu Arg Leu Ser Cys Val Val Ser
            20                  25


<210>  23
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR3

<400>  23
Pro Tyr Tyr Ser Asn Ser Val Lys Gly Arg Phe Ala Ile Thr Arg Asp
                5                   10                  15

His Ala Lys Asn Thr Ile His Leu Gln Met Asn Asn Leu Lys Ser Ala
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Ala Ala
        35                  40


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  FR4

<400>  24
Trp Gly His Gly Thr Gln Val Thr Val Ser
                5                   10


<210>  25
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH59

<400>  25
Gln Glu Val Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser His Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Thr Arg Asp His Ala Lys Asn Thr Ile His
65                  70                  75                  80

Leu Gln Met Asn Asn Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110

Thr Leu Val Thr Val Ser
        115


<210>  26
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60

<400>  26
Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Phe Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Asn Thr Ser Tyr Leu
65                  70                  75                  80

Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Gln Val Thr Val
            100                 105                 110
Ser


<210>  27
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH80

<400>  27
Gln Glu Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Phe Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Asn Thr Ser Tyr Leu
65                  70                  75                  80

Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110
Ser


<210>  28
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH81

<400>  28
Gln Val His Leu Val Glu Ser Gly Gly Gly Leu Val Lys Ala Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser Gly Ile Thr Leu Ser Ser Tyr
            20                  25                  30

Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Phe Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Asn Thr Ser Tyr Leu
65                  70                  75                  80

Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Gln Val Thr Val
            100                 105                 110

Ser


<210>  29
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH82

<400>  29
Gln Glu Arg Leu Val Glu Ser Gly Gly Gly Ser Val His Ala Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Ala Asp Phe Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Thr Ser Tyr Leu
65                  70                  75                  80

Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Thr Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110

Ser


<210>  30
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH83

<400>  30
Gln Glu Arg Leu Val Glu Ser Gly Gly Gly Ser Val His Ala Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Ala Asp Phe Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Lys Asn Asn Ala Lys Asn Thr Ser Tyr Leu
65                  70                  75                  80

Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Thr Tyr Tyr Cys Asn 
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Gln Val Thr Val
            100                 105                 110

Ser


<210>  31
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH84

<400>  31
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Phe Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asn Asn Ala Lys Asn Thr Ser Tyr Leu
65                  70                  75                  80

Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Ala Thr Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Gln Val Thr Val
            100                 105                 110

Ser


<210>  32
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86

<400>  32
Gln Glu Val Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asn Ser Val
    50                  55                  60

Lys Gly Arg Phe Ala Ile Thr Arg Asp His Ala Lys Asn Thr Ile His
65                  70                  75                  80

Leu Gln Met Asn Asn Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly His Gly
            100                 105                 110

Thr Gln Val Thr Val Ser
        115


<210>  33
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH87

<400>  33
Gln Glu Val Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu
                5                   10                  15
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asn Ser Val
    50                  55                  60

Lys Gly Arg Phe Ala Ile Thr Arg Asp His Ala Lys Asn Thr Ile His
65                  70                  75                  80

Leu Gln Met Asn Asn Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110

Thr Leu Val Thr Val Ser
        115


<210>  34
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH59

<400>  34
caggaggtac tgatggagtc tgggggagga ttggtgcagg ccggggagtc tctaagacta     60

tcctgtgcag cctctggacg cgccattagt agtattgtca tggcctggtg gcgccagact    120

ccaggggcgg aacgcgagtt tgtcgcctcc atcaatcggt ggggtggtac gccatactat    180

tcacactccg tgaagggccg attcaccatc accagggatc atgccaagaa tacgattcat    240

ctgcaaatga acaatctgaa atctgcggac acggccgttt actactgcgc tgcagcgtcg    300

acgttggatt cggggtatga ctactggggc caggggaccc ttgtcaccgt ctcc          354


<210>  35
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH60

<400>  35
caggagcagc tggtggagtc tgggggaggc tcggtgcagc ctggggggtc tctgagactc     60

tcctgtgtag tctctggagg catcttcacg atcaatgaca tggcctggtt ccgccaggct    120

ccagggaaac agcgcgagtt ggtcgcccat attagtagaa gtggtagcac atactataga    180

gacttcgtga agggccgatt caccatctcc agaaacaatg ccaagaacac gtcatatctg    240

caaatgaata acctgaaacc tgaggacacg gccacatatt actgtaattc gatcgaccgg    300

cccttatctt acggccaggg gacccaggtc accgtctcc                           339


<210>  36
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH80

<400>  36
caggagcagc tggtggagtc tgggggaggc tcggtgcagc ctggggggtc tctgagactc     60

tcctgtgtag tctctggagg catcttcacg atcaatgaca tggcctggtt ccgccaggct    120

ccagggaaac agcgcgagtt ggtcgcccat attagtagaa gtggtagcac atactataga    180

gacttcgtga agggccgatt caccatctcc agaaacaatg ccaagaacac gtcatatctg    240

caaatgaata acctgaaacc tgaggacacg gccacatatt actgtaattc gatcgaccgg    300

cccttatctt acggccaggg gaccctagtc actgtctcc                           339


<210>  37
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH81

<400>  37
caggtgcacc tggtagagtc tgggggagga ttggtcaagg ctgggggctc tctgagactc     60

tcctgtgtag tctctggaat taccttgagt agttattcca tggcctggtt ccgccaggct    120

ccagggaaac agcgcgagtt ggtcgcccat attagtagaa gtggtagcac atactataga    180

gacttcgtga agggccgatt caccatctcc agaaacaatg ccaagaacac gtcatatctg    240

caaatgaata acctgaaacc tgaggacacg gccacatatt actgtaattc gatcgaccgg    300

cccttatctt acggccaggg gacccaggtc accgtctcc                           339


<210>  38
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH82

<400>  38
caggagcgcc tggtggagtc tgggggaggc tcggtgcacg ctggggggtc tctgagactc     60

tcctgtgtag cctctggagg catcttcacg atcaatgaca tggcctggtt ccgccaggct    120

ccagggaagc agcgcgagtt ggtcgcccat atttccagaa gtggtagcac atactatgca    180

gacttcgtga agggccgatt caccatctcc aaaaacaatg ccaagaacac gtcatatctg    240

caaatgaaca gcctgaaacc tgacgacacg gccacatatt attgtaattc gatcgaccgg    300

cccttatctt atggccaggg gaccctggtc accgtctcc                           339


<210>  39
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH83

<400>  39
caggagcgcc tggtggagtc tgggggaggc tcggtgcacg ctggggggtc tctgagactc     60

tcctgtgtag cctctggagg catcttcacg atcaatgaca tggcctggtt ccgccaggct    120

ccagggaagc agcgcgagtt ggtcgcccat atttccagaa gtggtagcac atactatgca    180

gacttcgtga agggccgatt caccatctcc aaaaacaatg ccaagaacac gtcatatctg    240

caaatgaaca gcctgaaacc tgacgacacg gccacatatt attgtaattc gatcgaccgg    300

cccttatctt atggccaggg gacccaggtc accgtctcc                           339


<210>  40
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH84

<400>  40
caggtgcagc tggtggagtc tgggggaggc tcggtgcagc ctggggggtc tctgagactc     60

tcctgtgtag tctctggagg catcttcacg atcaatgaca tggcctggtt ccgccaggct    120

ccagggaaac agcgcgagtt ggtcgcccat attagtagaa gtggtagcac atactataga    180

gacttcgtga agggccgatt caccatctcc agaaacaatg ccaagaacac gtcatatctg    240

caaatgaata acctgaaacc tgaggacacg gccacatatt actgtaattc gatcgaccgg    300

cccttatctt acggccaggg gacccaggtc accgtctcc                           339


<210>  41
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86

<400>  41
caggaggtac tgatggagtc tgggggagga ttggtgcagg ccggggagtc tctaagacta     60

tcctgtgcag cctctggacg cgccattagt agtattgtca tggcctggtg gcgccagact    120

ccaggggcgg aacgcgagtt tgtcgcctcc atcaatcggt ggggtggtac gccatactat    180

tcgaactccg tgaagggccg attcgccatc accagggatc atgccaagaa tacgattcat    240

ctgcaaatga acaatctgaa atctgcggac acggccgttt actactgcgc tgcagcgtcg    300

acgttggatt cggggtatga ctactggggc cacgggaccc aagtcaccgt ctcc          354


<210>  42
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH87

<400>  42
caggaagtgc tgatggaaag cggcggcggc ctggtgcagg cgggcgaaag cctgcgcctg     60

agctgcgcgg cgagcggccg cgcgattagc agcattgtga tggcgtggtg gcgccagacc    120

ccgggcgcgg aacgcgaatt tgtggcgagc attaaccgct ggggcggcac cccgtattat    180

agcaacagcg tgaaaggccg ctttgcgatt acccgcgatc atgcgaaaaa caccattcat    240

ctgcagatga acaacctgaa aagcgcggat accgcggtgt attattgcgc ggcggcgagc    300

accctggata gcggctatga ttattggggc cagggcaccc tggtgaccgt gagc          354


<210>  43
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  43
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Val Ser
            20                  25


<210>  44
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  44
Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                5                   10                  15

Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
            20                  25                  30

Asp Thr Ala Thr Tyr Tyr Cys Asn Ser Ile
        35                  40


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60人源化FR4

<400>  45
Gly Gln Gly Thr Leu Val Thr Val Ser
                5


<210>  46
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  46
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser
            20                  25


<210>  47
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR2

<400>  47
Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                5                   10                  15

Ala His Ile


<210>  48
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  48
Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                5                   10                  15

Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Asn Ser Ile
        35                  40


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR4

<400>  49
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                5                   10


<210>  50
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  50
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser
            20                  25


<210>  51
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  51
Thr Tyr Tyr Arg Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                5                   10                  15

Asn Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Asn Ser Ile
        35                  40


<210>  52
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  52
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser
            20                  25


<210>  53
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  53
Thr Tyr Tyr Arg Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
                5                   10                  15

Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
            20                  25                  30

Asp Thr Ala Thr Tyr Tyr Cys Asn Ser Ile
        35                  40


<210>  54
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  54
Thr Tyr Tyr Arg Asp Phe Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
                5                   10                  15

Asn Ser Lys Asn Thr Ser Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu
            20                  25                  30

Asp Thr Ala Thr Tyr Tyr Cys Asn Ser Ile
        35                  40


<210>  55
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  55
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Ala Ser
            20                  25


<210>  56
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  56
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25


<210>  57
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  57
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25


<210>  58
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  58
Pro Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
                5                   10                  15

Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Ala Ala
        35                  40


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR4

<400>  59
Trp Gly Gln Gly Thr Leu Val Thr Val Ser
                5                   10


<210>  60
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  60
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25


<210>  61
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR2

<400>  61
Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
                5                   10                  15
Ala Ser Ile


<210>  62
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  62
Pro Tyr Tyr Ser Ala Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                5                   10                  15

Asp Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Ala Ala
        35                  40


<210>  63
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR4

<400>  63
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                5                   10


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR4

<400>  64
Gly His Gly Thr Leu Val Thr Val Ser
                5


<210>  65
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  65
Pro Tyr Tyr Ser Asn Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
                5                   10                  15

Asn Ser Lys Asn Thr Ile His Leu Gln Met Asn Ser Leu Arg Ser Glu
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Ala Ala
        35                  40


<210>  66
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  66
Pro Tyr Tyr Ser Asn Ser Val Lys Gly Arg Phe Ala Ile Ser Arg Asp
                5                   10                  15

Asn Ser Lys Asn Thr Ile His Leu Gln Met Asn Ser Leu Arg Ser Glu
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Ala Ala
        35                  40


<210>  67
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR1

<400>  67
Gln Glu Val Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25


<210>  68
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  68
Pro Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp
                5                   10                  15

His Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Ala Ala
        35                  40


<210>  69
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR3

<400>  69
Pro Tyr Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
                5                   10                  15

His Ala Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Ala
            20                  25                  30

Asp Thr Ala Val Tyr Tyr Cys Ala Ala
        35                  40


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR4

<400>  70
Gly Pro Gly Thr Gln Val Thr Val Ser
                5


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  人源化FR4

<400>  71
Gly Gln Gly Thr Gln Val Thr Val Ser
                5


<210>  72
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V1

<400>  72
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Gly Ile Phe Thr Ile Asn 
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Ser Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110

Ser


<210>  73
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V2

<400>  73
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Ser Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110

Ser Ser


<210>  74
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V3

<400>  74
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Ser Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110

Ser Ser


<210>  75
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V5

<400>  75
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Phe Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Leu Val Thr Val
            100                 105                 110

Ser


<210>  76
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V6

<400>  76
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15
 
Ser Leu Arg Leu Ser Cys Val Val Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Phe Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ser Tyr Leu
65                  70                  75                  80

Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110

Ser


<210>  77
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60_GKV1

<400>  77
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Ser Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110

Ser


<210>  78
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH60_GKV2

<400>  78
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ile Phe Thr Ile Asn
            20                  25                  30

Asp Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45

Ala His Ile Ser Arg Ser Gly Ser Thr Tyr Tyr Arg Asp Ser Val Lys
    50                  55                  60

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80

Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn
                85                  90                  95

Ser Ile Asp Arg Pro Leu Ser Tyr Gly Gln Gly Thr Gln Val Thr Val
            100                 105                 110

Ser


<210>  79
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V1

<400>  79
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asp Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110

Thr Leu Val Thr Val Ser
        115


<210>  80
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V2

<400>  80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Ala Pro Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110

Thr Leu Val Thr Val Ser Ser
        115


<210>  81
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V4

<400>  81
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asp Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly His Gly
            100                 105                 110

Thr Leu Val Thr Val Ser
        115


<210>  82
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V5

<400>  82
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asn Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Ile His
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110

Thr Leu Val Thr Val Ser
        115


<210>  83
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V6

<400>  83
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Glu
                5                   10                  15
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asn Ser Val
    50                  55                  60

Lys Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Ile His
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly His Gly
            100                 105                 110

Thr Leu Val Thr Val Ser
        115


<210>  84
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86_GKV1

<400>  84
Gln Glu Val Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15
 
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asp Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly His Gly
            100                 105                 110

Thr Gln Val Thr Val Ser
        115


<210>  85
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86_GKV2

<400>  85
Gln Glu Val Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val 
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asp Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly Pro Gly
            100                 105                 110

Thr Gln Val Thr Val Ser
        115


<210>  86
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  BH86_GKV3

<400>  86
Gln Glu Val Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                5                   10                  15

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Ile Ser Ser Ile
            20                  25                  30

Val Met Ala Trp Trp Arg Gln Thr Pro Gly Ala Glu Arg Glu Phe Val
        35                  40                  45

Ala Ser Ile Asn Arg Trp Gly Gly Thr Pro Tyr Tyr Ser Asp Ser Val
    50                  55                  60

Lys Gly Arg Phe Thr Ile Ser Arg Asp His Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80

Leu Gln Met Asn Ser Leu Lys Ser Ala Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95

Ala Ala Ala Ser Thr Leu Asp Ser Gly Tyr Asp Tyr Trp Gly Gln Gly
            100                 105                 110

Thr Gln Val Thr Val Ser
        115


<210>  87
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V1

<400>  87
caggtgcagc tggtagagag cggaggtggt ctcgtacaac cgggaggatc tctcaggctc     60

tcatgtgcgg tcagtggagg catctttaca attaacgaca tggcctggtt taggcaagct    120

ccgggaaaac aaagagagct tgttgcgcat atttctcggt cagggagtac atactaccgg    180

gacagcgtta aaggaaggtt tactatatct cgggacaata gtaagaacac tctgtacttg    240

cagatgaact cccttagagc agaggatacc gcaacttatt actgcaatag tattgaccgc    300

cctctcagtt acggccaggg tactctggtg acagtgagc                           339


<210>  88
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V2

<400>  88
caggtgcaac ttgtcgaaag tgggggagga gtagttcaac ccggcgggtc actgagactg     60

tcttgcgtcg tcagcggcgg tatttttacc ataaacgata tggcctgggt ccggcaggcg    120

ccaggtaaag gcctggaatg ggtcgcgcac atctcccgaa gtggctccac gtactatagg    180

gattctgtaa aggggcgctt tacaatatca agggacaata gcaaaaatac actctacctg    240

caaatgaact ctctgcgggc tgaagacacg gcagtatatt attgcaatag cattgaccgg    300

cccctgtcat acggccaagg aacgctcgtt acggtctcca gc                       342


<210>  89
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V3

<400>  89
caggtgcaac ttgtcgaaag tgggggagga gtagttcaac ccggcgggtc actgagactg     60

tcttgcgtcg tcagcggcgg tatttttacc ataaacgata tggcctgggt ccggcaggcg    120

ccaggtaaag gcctggaatg ggtcgcgcac atctcccgaa gtggctccac gtactatagg    180

gattctgtaa aggggcgctt tacaatatca agggacaata gcaaaaatac actctacctg    240

caaatgaact ctctgcgggc tgaagacacg gcagtatatt attgcaatag cattgaccgg    300

cccctgtcat acggccaagg aacgctcgtt acggtctcca gc                       342


<210>  90
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V5

<400>  90
caggtccagt tggttgagtc aggaggggga ttggtacagc caggcggaag tttgcgcctt     60

tcatgtgtgg tttccggggg catcttcact ataaacgata tggcctggtt ccgccaagct    120

cctgggaaac aacgcgaact tgtagcccat atatcccgat ccggcagtac atattaccga    180

gacttcgtca aagggcgctt tacaattagc cgagacaatt ctaaaaacac gctctatttg    240

caaatgaact ctttgcgggc cgaagataca gcgacttact actgcaactc catcgacaga    300

ccgctctctt acgggcaagg gactcttgtg acggtaagc                           339


<210>  91
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH60V6

<400>  91
caggtgcagc tggtggaaag cggcggcggc ctggtgcagc cgggcggcag cctgcgcctg     60

agctgcgtgg tgagcggcgg catttttacc attaacgata tggcgtggtt tcgccaggcg    120

ccgggcaaac agcgcgaact ggtggcgcat attagccgca gcggcagcac ctattatcgc    180

gattttgtga aaggccgctt taccattagc cgcgataaca gcaaaaacac cagctatctg    240

cagatgaaca acctgcgcgc ggaagatacc gcgacctatt attgcaacag cattgatcgc    300

ccgctgagct atggccaggg caccctggtg accgtgagc                           339
 

<210>  92
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH60_GKV1

<400>  92
caggtacaac ttgtggagtc aggtgggggc ctcgtgcaac cgggcggaag tctgagactc     60

agttgtgttg cttccggggg gattttcacc ataaacgaca tggcttggtt cagacaagct    120 

ccaggcaagc aacgagaact ggttgcacat attagccggt ccgggagtac atattatcgg    180

gatagtgtaa aaggaagatt tactatttcc agggataatg caaaaaattc tctgtacctt    240

cagatgaaca gcctccgcgc agaggataca gcagtctact actgtaattc tattgaccgc    300

ccgttgtcct acgggcaagg aacgttggta acagtgagc                           339


<210>  93
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH60_GKV2

<400>  93
caggttcaac tggtagaaag cggcggcggc ttggttcaac ctggcggttc tctgaggctt     60

tcttgtgcag catctggtgg gatattcacg attaatgata tggcctggtt taggcaagcg    120

ccaggaaaac agcgggagct tgtggcacat atatctagga gcgggagtac ctactataga    180

gacagcgtga aggggagatt cactatttct agggacaacg ctaagaacag tctctacctg    240

caaatgaaca gccttagagc cgaggacacc gctgtctatt attgtaatag catagatagg    300

cccctgagtt acgggcaagg gacgcaagtc acggtaagc                           339


<210>  94
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V1

<400>  94
caggtgcagc ttgtggaaag cggcggaggg ttggtccaag ccggggagtc tcttagactg     60

agttgtgctg caagcggacg ggcaatatca agtatcgtca tggcttggtg gaggcagaca    120 

cctggcgctg agagggagtt cgtcgcctct ataaacaggt ggggtgggac tccgtattat    180

tccgattctg taaaaggaag attcactatt tccagggata attcaaaaaa caccctctat    240

cttcagatga actcacttcg agcagaagat acagctgtct actactgtgc ggctgcaagt    300

acactggatt caggatatga ctattggggc cagggaactc tggtaaccgt gagc          354


<210>  95
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V2

<400>  95
gaagtgcaac ttgttgagag cggaggtggt cttgtaaaac ccggcgggtc tttgcgactc     60

tcctgtgccg caagtggccg ggccatcagc tccattgtaa tggcgtgggt aagacaagcg    120

cctggaaagg ggttggagtg ggtagcttca ataaaccggt ggggcggcac gccctactat    180

agtgcgcccg taaaaggacg attcaccata tctcgggatg acagtaagaa tactctgtat    240

ctccaaatga atagccttaa aacggaagat acagcggtat actattgtgc tgctgcgagc    300

acattggatt caggctacga ctattggggc cagggcaccc tcgtgacagt gtctagc       357


<210>  96
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V4

<400>  96
caggtccagc ttgttgagtc tggcggaggt ctggtacagg ccggggagtc actgaggctt     60

agctgtgcag catccggtcg ggccatatcc agtatcgtta tggcttggtg gcgccaaacg    120

cctggtgcgg aacgggagtt cgtagcaagc atcaaccgct ggggaggaac tccatattat    180

tctgacagcg tgaagggccg gttcacgata agtagagata actctaagaa caccctgtac    240

ctccaaatga atagcctccg ggcagaggat acggcagtgt attactgtgc ggcggcatct    300

acgctggact caggctacga ttactggggc cacgggactt tggtcacggt gagc          354


<210>  97
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V5

<400>  97
caggtgcaac tcgtggaatc aggaggcgga ctggtgcaag ccggagaatc actccgcctc     60

agttgtgccg catcaggtcg agccataagt tcaattgtga tggcgtggtg gaggcagacc    120

cctggtgccg aacgcgaatt tgtggcctct attaacagat ggggtggaac gccctattac    180

tcaaactctg tgaaaggtcg atttaccatt agccgggaca acagtaagaa tactatacac    240

ctgcaaatga actccctcag gagcgaagat acggcagttt attattgtgc tgcggcgagc    300

acgcttgact ctggatacga ctattggggt caaggaacac tcgtgacggt cagc          354


<210>  98
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86V6

<400>  98
caggtacagc tggttgagtc cggtgggggt ctcgtccagg ctggcgagtc cttgagactt     60

tcttgcgccg cgtctggacg agctatttct agtatcgtta tggcgtggtg gagacagact    120

cctggagcag aacgcgagtt tgtcgcaagc atcaatagat ggggagggac gccctactac    180

tctaattctg taaaaggccg ctttgcaatt tctagggata attctaagaa tacaatccat    240

cttcagatga actccctgag atcagaggac acggctgttt attactgtgc ggcagcgtca    300

acactggatt ccgggtatga ctattgggga cacgggacgc ttgtcaccgt cagc          354


<210>  99
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86_GKV1

<400>  99
caggtacagc tggttgagtc cggtgggggt ctcgtccagg ctggcgagtc cttgagactt     60

tcttgcgccg cgtctggacg agctatttct agtatcgtta tggcgtggtg gagacagact    120

cctggagcag aacgcgagtt tgtcgcaagc atcaatagat ggggagggac gccctactac    180

tctaattctg taaaaggccg ctttgcaatt tctagggata attctaagaa tacaatccat    240

cttcagatga actccctgag atcagaggac acggctgttt attactgtgc ggcagcgtca    300

acactggatt ccgggtatga ctattgggga cacgggacgc ttgtcaccgt cagc          354


<210>  100
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86_GKV2

<400>  100
caggaggtgc ttgtagaaag tggagggggg cttgtacaac ctggaggtag ccttaggttg     60

tcttgcgctg cttcaggcag agctatcagc agcatagtga tggcttggtg gagacaaacc    120

cccggcgccg agcgggaatt tgttgcgtca ataaatcgct ggggtggcac tccgtactat    180

tcagactccg ttaaaggccg gtttaccatt agtagagacc acgcaaaaaa taccctttat    240

ttgcaaatga actctctcaa gagcgccgac acagctgtat attactgtgc agcagcttcc    300

acccttgact ctggttatga ctattgggga cctgggacgc aggtgacagt tagc          354


<210>  101
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  BH86_GKV3

<400>  101
caggaagttc tcgtcgaaag cgggggtggt ctcgttcaac ctggaggctc tctgcggctc     60

agttgtgcag cgtctggtcg agccatcagt tccatagtaa tggcttggtg gcgccaaaca    120

cctggagctg agagagagtt cgtagccagt ataaatcgat ggggcggaac cccatattac    180

tcagactctg taaaagggcg attcaccatc agccgagacc acgcgaaaaa cactctttac    240

ttgcaaatga acagcttgaa atcagctgat acggctgttt actattgcgc ggctgcttct    300

acactggata gtggttatga ctattgggga caggggactc aagtaactgt cagc          354


<210>  102
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α信号肽

<400>  102
atggccttac cagtgaccgc cttgctcctg ccgctggcct tgctgctcca cgccgccagg     60

ccg                                                                   63


<210>  103
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α信号肽

<400>  103
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu
                5                   10                  15

His Ala Ala Arg Pro
            20


<210>  104
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α铰链区

<400>  104
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg     60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg    120

gacttcgcct gtgat                                                     135


<210>  105
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α铰链区

<400>  105
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala
                5                   10                  15

Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly
            20                  25                  30

Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp
        35                  40                  45


<210>  106
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α跨膜结构域

<400>  106
atctacatct gggcgccctt ggccgggact tgtggggtcc ttctcctgtc actggttatc     60

accctttact gcaaa                                                      75


<210>  107
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD8α跨膜结构域

<400>  107
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
                5                   10                  15

Ser Leu Val Ile Thr Leu Tyr Cys Lys
            20                  25


<210>  108
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  4-1BB共刺激结构域

<400>  108
cggggcagaa agaaactcct gtatatattc aaacaaccat ttatgagacc agtacaaact     60

actcaagagg aagatggctg tagctgccga tttccagaag aagaagaagg aggatgtgaa     120


<210>  109
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  4-1BB共刺激结构域

<400>  109
Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                5                   10                  15

Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro
            20                  25                  30

Glu Glu Glu Glu Gly Gly Cys Glu
        35                  40


<210>  110
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ胞内信号传导结构域

<400>  110
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctataacg agctcaatct aggacgaaga gaggagtacg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg agaaggaaga accctcagga aggcctgtac    180

aatgaactgc agaaagataa gatggcggag gcctacagtg agattgggat gaaaggcgag    240

cgccggaggg gcaaggggca cgatggcctt taccagggtc tcagtacagc caccaaggac    300

acctacgacg cccttcacat gcaggccctg ccccctcgc                           339


<210>  111
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ胞内信号传导结构域

<400>  111
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                5                   10                  15

Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60

Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu
65                  70                  75                  80

Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr
                85                  90                  95

Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro
            100                 105                 110

Arg


<210>  112
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28共刺激结构域

<400>  112
aggagtaaga ggagcaggct cctgcacagt gactacatga acatgactcc ccgccgcccc     60

gggcccaccc gcaagcatta ccagccctat gccccaccac gcgacttcgc agcctatcgc    120

tcc                                                                  123


<210>  113
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28共刺激结构域

<400>  113
Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
                5                   10                  15

Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro
            20                  25                  30

Pro Arg Asp Phe Ala Ala Tyr Arg Ser
        35                  40


<210>  114
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28跨膜结构域

<400>  114
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu
                5                   10                  15

Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val
            20                  25


<210>  115
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28跨膜结构域

<400>  115
ttttgggtcc tcgtcgtagt tggaggggta cttgcctgtt atagcctcct ggttaccgta     60

gcatttatta tattctgggt g                                               81


<210>  116
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ信号传导结构域

<400>  116
Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln
                5                   10                  15

Gly Gln Asn Gln Leu Phe Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu
            20                  25                  30

Phe Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly
        35                  40                  45

Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu
    50                  55                  60

Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly
65                  70                  75                  80

Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Phe Gln Gly Leu Ser
                85                  90                  95

Thr Ala Thr Lys Asp Thr Phe Asp Ala Leu His Met Gln Ala Leu Pro
            100                 105                 110

Pro Arg


<210>  117
<211>  342
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD3ζ信号传导结构域

<400>  117
ctgagagtga agttcagcag gagcgcagac gcccccgcgt accagcaggg ccagaaccag     60

ctctttaacg agctcaatct aggacgaaga gaggagttcg atgttttgga caagagacgt    120

ggccgggacc ctgagatggg gggaaagccg cagagaagga agaaccctca ggaaggcctg    180

tacaatgaac tgcagaaaga taagatggcg gaggcctaca gtgagattgg gatgaaaggc    240

gagcgccgga ggggcaaggg gcacgatggc cttttccagg gtctcagtac agccaccaag    300

gacacctttg acgcccttca catgcaggcc ctgccccctc gc                       342


<210>  118
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  B2M信号肽

<400>  118
Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser
                5                   10                  15

Gly Leu Glu Ala
            20


<210>  119
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  B2M信号肽

<400>  119
atgtcccgct ctgttgcttt ggctgtgctg gcccttttgt cccttagcgg actggaggcc     60


<210>  120
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  CD28铰链区

<400>  120
Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn
                5                   10                  15

Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu
            20                  25                  30

Phe Pro Gly Pro Ser Lys Pro
        35


<210>  121
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  CD28铰链区

<400>  121
attgaagtta tgtatcctcc tccttaccta gacaatgaga agagcaatgg aaccattatc     60

catgtgaaag ggaaacacct ttgtccaagt cccctatttc ccggaccttc taagccc       117


<210>  122
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<221>
<223>  IgG4铰链区

<400>  122
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro
                5                   10


<210>  123
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<221>
<223>  IgG4铰链区

<400>  123
gaaagcaaat acgggccgcc gtgtccaccc tgtccg                               36


