﻿                         序列表

<110>  浙江工业大学、浙江永太科技股份有限公司、浙江永太药业有限公司

<120>  转氨酶突变体及其在制备西他列汀中间体中的应用

<160>  4

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  1011
<212>  DNA
<213>  分枝杆菌(Mycolicibacterrium)

<400>  1
atgggcatcg ataccggtac ttccatcctg gttcatgtcg aagacggcga tgttcgcgag        60
gacaccccgg caggttctgt aatccagtac tctgactacg aaattgatta cagctctccg       120
ttcgccggtg gcgtggcttg gattgaaggc gagtatctgc cggccgagga cgctaaaatt       180
tctgatttcg atacgggttt ttaccattct gacctgacgt acatggtagc tcacgtatgg       240
catggcaaca ttttccgcct gggcgatcac ctggatcgtc tgctggatgg tgcccgtaaa       300
ctgcgcaacg attctggtat gactaaggat gaactggctg acatcaccaa aaaatgcgtt       360
tctctgtctc agcatttcga agcgtttgtc aacctgacta tcacccgtca ctatggtgat       420
ctgaagggtg agaaagacct gagcaaactg acccatcagg tttatatcta tgcgatcccg       480
gaagtttggg ctttcattcc ggcggaacag atctttggta ccactgccgt tgtgccgcgt       540
catgtgcgcc gcgcaggccg caataccgta gacccgacga tcaagaacta ccaatggggt       600
gatctgaccg cggcgtcttt tgaggccaaa gatcgtggcg cccgtacggc tatcctgatg       660
gatgcggata actgcgtagc cgaaggtccg ggtttcaacg tttgtattgt aaaggtgggc       720
aaactggcat ctccgagcca ctacgctggc ttcggcattc tgcgcaaaac cgttttcgaa       780
attgcaggtg ctatgttcgg tgaggcccat ctgcgtagca ttacttctca cgagctgtat       840
gacgcggacg agattatggc ggtgaccatg ctggatggcg ttactccgat caacactctg       900
gacggtgtac cgattcgcga cggtgttccg ggcccggtta cggttgctat tcgcgaccgt       960
ttctgggctc tgatggacga gccgtacccg gtgatcgaag atatctgcta c               1011

<210>  2
<211>  337
<212>  PRT
<213>  分枝杆菌(Mycolicibacterrium)

<400>  2
Met Gly Ile Asp Thr Gly Thr Ser Ile Leu Val His Val Glu Asp Gly 
1               5                   10                  15      
Asp Val Arg Glu Asp Thr Pro Ala Gly Ser Val Ile Gln Tyr Ser Asp 
            20                  25                  30          
Tyr Glu Ile Asp Tyr Ser Ser Pro Phe Ala Gly Gly Val Ala Trp Ile 
        35                  40                  45              
Glu Gly Glu Tyr Leu Pro Ala Glu Asp Ala Lys Ile Ser Asp Phe Asp 
    50                  55                  60                  
Thr Gly Phe Tyr His Ser Asp Leu Thr Tyr Met Val Ala His Val Trp 
65                  70                  75                  80  
His Gly Asn Ile Phe Arg Leu Gly Asp His Leu Asp Arg Leu Leu Asp 
                85                  90                  95      
Gly Ala Arg Lys Leu Arg Asn Asp Ser Gly Met Thr Lys Asp Glu Leu 
            100                 105                 110         
Ala Asp Ile Thr Lys Lys Cys Val Ser Leu Ser Gln His Phe Glu Ala 
        115                 120                 125             
Phe Val Asn Leu Thr Ile Thr Arg His Tyr Gly Asp Leu Lys Gly Glu 
    130                 135                 140                 
Lys Asp Leu Ser Lys Leu Thr His Gln Val Tyr Ile Tyr Ala Ile Pro 
145                 150                 155                 160 
Glu Val Trp Ala Phe Ile Pro Ala Glu Gln Ile Phe Gly Thr Thr Ala 
                165                 170                 175     
Val Val Pro Arg His Val Arg Arg Ala Gly Arg Asn Thr Val Asp Pro 
            180                 185                 190         
Thr Ile Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala Ala Ser Phe Glu 
        195                 200                 205             
Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Met Asp Ala Asp Asn 
    210                 215                 220                 
Cys Val Ala Glu Gly Pro Gly Phe Asn Val Cys Ile Val Lys Val Gly 
225                 230                 235                 240 
Lys Leu Ala Ser Pro Ser His Tyr Ala Gly Phe Gly Ile Leu Arg Lys 
                245                 250                 255     
Thr Val Phe Glu Ile Ala Gly Ala Met Phe Gly Glu Ala His Leu Arg 
            260                 265                 270         
Ser Ile Thr Ser His Glu Leu Tyr Asp Ala Asp Glu Ile Met Ala Val 
        275                 280                 285             
Thr Met Leu Asp Gly Val Thr Pro Ile Asn Thr Leu Asp Gly Val Pro 
    290                 295                 300                 
Ile Arg Asp Gly Val Pro Gly Pro Val Thr Val Ala Ile Arg Asp Arg 
305                 310                 315                 320 
Phe Trp Ala Leu Met Asp Glu Pro Tyr Pro Val Ile Glu Asp Ile Cys 
                325                 330                 335     
Tyr 
    

<210>  3
<211>  1011
<212>  DNA
<213>  分枝杆菌(Mycolicibacterrium)

<400>  3
atgggcatcg ataccggtac ttccatcctg gttcatgtcg aagacggcga tgttcgcgag        60
gacaccccgg caggttctgt aatccagtac tctgactacg aaattgatta cagctctccg       120
ttcgccggtg gcgtggcttg gattgaaggc gagtatctgc cggccgagga cgctaaaatt       180
tctgatttcg atacgggttt ttaccattct gacctgacgc ccatggtagc tcacgtatgg       240
catggcaaca ttttccgcct gggcgatcac ctggatcgtc tgctggatgg tgcccgtaaa       300
ctgcgcaacg attctggtat gactaaggat gaactggctg acatcaccaa aaaatgcgtt       360
tctctgtctc agcatttcga agcgtttgtc aacctgacta tcacccgtca ctatggtgat       420
ctgaagggtg agaaagacct gagcaaactg acccatcagg tttatatcta tgcgatcccg       480
gaagtttggg ctttcattcc ggcggaacag atctttggta ccactgccgt tgtgccgcgt       540
catgtgcgcc gcgcaggccg caataccgta gacccgacga tcaagaacta ccaatggggt       600
gatctgaccg cggcgtcttt tgaggccaaa gatcgtggcg cccgtacggc tatcctgatg       660
gatgcggata actgcgtagc cgatggtccg ggtttcaacg tttgtattgt aaaggtgggc       720
aaactggcat ctccgagcca ctacgctggc ttcggcattg cgcgcaaaac cgttttcgaa       780
attgcaggtg ctatgttcgg tgaggcccat ctgcgtagca ttacttctca cgagctgtat       840
gacgcggacg agattatggc ggtgaccacg ctggatggcg ttactccgat caacactctg       900
gacggtgtac cgattcgcga cggtgttccg ggcccggtta cggttgctat tcgcgaccgt       960
ttctgggctc tgatggacga gccgtacccg gtgatcgaag atatctgcta c               1011

<210>  4
<211>  337
<212>  PRT
<213>  分枝杆菌(Mycolicibacterrium)

<400>  4
Met Gly Ile Asp Thr Gly Thr Ser Ile Leu Val His Val Glu Asp Gly 
1               5                   10                  15      
Asp Val Arg Glu Asp Thr Pro Ala Gly Ser Val Ile Gln Tyr Ser Asp 
            20                  25                  30          
Tyr Glu Ile Asp Tyr Ser Ser Pro Phe Ala Gly Gly Val Ala Trp Ile 
        35                  40                  45              
Glu Gly Glu Tyr Leu Pro Ala Glu Asp Ala Lys Ile Ser Asp Phe Asp 
    50                  55                  60                  
Thr Gly Phe Tyr His Ser Asp Leu Thr Pro Met Val Ala His Val Trp 
65                  70                  75                  80  
His Gly Asn Ile Phe Arg Leu Gly Asp His Leu Asp Arg Leu Leu Asp 
                85                  90                  95      
Gly Ala Arg Lys Leu Arg Asn Asp Ser Gly Met Thr Lys Asp Glu Leu 
            100                 105                 110         
Ala Asp Ile Thr Lys Lys Cys Val Ser Leu Ser Gln His Phe Glu Ala 
        115                 120                 125             
Phe Val Asn Leu Thr Ile Thr Arg His Tyr Gly Asp Leu Lys Gly Glu 
    130                 135                 140                 
Lys Asp Leu Ser Lys Leu Thr His Gln Val Tyr Ile Tyr Ala Ile Pro 
145                 150                 155                 160 
Glu Val Trp Ala Phe Ile Pro Ala Glu Gln Ile Phe Gly Thr Thr Ala 
                165                 170                 175     
Val Val Pro Arg His Val Arg Arg Ala Gly Arg Asn Thr Val Asp Pro 
            180                 185                 190         
Thr Ile Lys Asn Tyr Gln Trp Gly Asp Leu Thr Ala Ala Ser Phe Glu 
        195                 200                 205             
Ala Lys Asp Arg Gly Ala Arg Thr Ala Ile Leu Met Asp Ala Asp Asn 
    210                 215                 220                 
Cys Val Ala Asp Gly Pro Gly Phe Asn Val Cys Ile Val Lys Val Gly 
225                 230                 235                 240 
Lys Leu Ala Ser Pro Ser His Tyr Ala Gly Phe Gly Ile Ala Arg Lys 
                245                 250                 255     
Thr Val Phe Glu Ile Ala Gly Ala Met Phe Gly Glu Ala His Leu Arg 
            260                 265                 270         
Ser Ile Thr Ser His Glu Leu Tyr Asp Ala Asp Glu Ile Met Ala Val 
        275                 280                 285             
Thr Thr Leu Asp Gly Val Thr Pro Ile Asn Thr Leu Asp Gly Val Pro 
    290                 295                 300                 
Ile Arg Asp Gly Val Pro Gly Pro Val Thr Val Ala Ile Arg Asp Arg 
305                 310                 315                 320 
Phe Trp Ala Leu Met Asp Glu Pro Tyr Pro Val Ile Glu Asp Ile Cys 
                325                 330                 335     
Tyr 
    

