                         SEQUENCE LISTING

<110>  LA JOLLA INSTITUTE FOR IMMUNOLOGY
       SAPHIRE, Erica Ollman
 
<120>  CORONAVIRUS SPIKE GLYCOPROTEIN WITH IMPROVED EXPRESSION AND 
       STABILITY

<130>  LJII:2012WO

<140>  PCT/US2021/056037
<141>  2021-10-21

<150>  US 63/094,451
<151>  2020-10-21

<150>  US 63/170,236
<151>  2021-04-02

<150>  US 63/212,814
<151>  2021-06-21

<150>  US 63/234,497
<151>  2021-08-18

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_USEO1

<400>  1

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln 
    1175                 1180                 


<210>  2
<211>  1182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_USEO3

<400>  2

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Pro Ser Ile Ile Ala Tyr Thr Met Ser 
            660                 665                 670         


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
        675                 680                 685             


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
    690                 695                 700                 


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
705                 710                 715                 720 


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
                725                 730                 735     


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
            740                 745                 750         


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
        755                 760                 765             


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
    770                 775                 780                 


Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val 
785                 790                 795                 800 


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
                805                 810                 815     


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
            820                 825                 830         


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
        835                 840                 845             


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
    850                 855                 860                 


Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe 
865                 870                 875                 880 


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
                885                 890                 895     


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
            900                 905                 910         


Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
        915                 920                 925             


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
    930                 935                 940                 


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro 
945                 950                 955                 960 


Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln 
                965                 970                 975     


Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile 
            980                 985                 990         


Arg Ala Ser Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
        995                 1000                 1005             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1010                 1015                 1020             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1025                 1030                 1035             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1040                 1045                 1050             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1055                 1060                 1065             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1070                 1075                 1080             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1085                 1090                 1095             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1100                 1105                 1110             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1115                 1120                 1125             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1130                 1135                 1140             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1145                 1150                 1155             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1160                 1165                 1170             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln 
    1175                 1180         


<210>  3
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_USEO4

<400>  3

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Pro Gly Pro Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln 
    1175                 1180                 


<210>  4
<211>  1188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_USEO5

<400>  4

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Gly Gly Gly Ser Ser Ile 
            660                 665                 670         


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
        675                 680                 685             


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
    690                 695                 700                 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
705                 710                 715                 720 


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
                725                 730                 735     


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
            740                 745                 750         


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
        755                 760                 765             


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
    770                 775                 780                 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp 
785                 790                 795                 800 


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
                805                 810                 815     


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
            820                 825                 830         


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
        835                 840                 845             


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
    850                 855                 860                 


Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met 
865                 870                 875                 880 


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
                885                 890                 895     


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
            900                 905                 910         


Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu 
        915                 920                 925             


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
    930                 935                 940                 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
945                 950                 955                 960 


Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg Leu 
                965                 970                 975     


Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu 
            980                 985                 990         


Ile Arg Ala Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
        995                 1000                 1005             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1010                 1015                 1020             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1025                 1030                 1035             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1055                 1060                 1065             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1070                 1075                 1080             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1085                 1090                 1095             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1100                 1105                 1110             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1115                 1120                 1125             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1130                 1135                 1140             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1145                 1150                 1155             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1160                 1165                 1170             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1175                 1180                 1185             


<210>  5
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_DS1

<400>  5

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Cys Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Cys Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
        675                 680                 685             


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  
    1190                 1195 


<210>  6
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_DS3

<400>  6

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
        675                 680                 685             


Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  
    1190                 1195 


<210>  7
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_DS4

<400>  7

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
        675                 680                 685             


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Cys Gln 
    1010                 1015                 1020             


Ser Lys  Arg Cys Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  
    1190                 1195 


<210>  8
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_DS5

<400>  8

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Cys 
        675                 680                 685             


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Cys Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  
    1190                 1195 


<210>  9
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PentaPro (5P)

<400>  9

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
        675                 680                 685             


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  
    1190                 1195 


<210>  10
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5P_USEO1

<400>  10

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln 
    1175                 1180                 


<210>  11
<211>  1182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5P_USEO3

<400>  11

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Pro Ser Ile Ile Ala Tyr Thr Met Ser 
            660                 665                 670         


Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile 
        675                 680                 685             


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
    690                 695                 700                 


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
705                 710                 715                 720 


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
                725                 730                 735     


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
            740                 745                 750         


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
        755                 760                 765             


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
    770                 775                 780                 


Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val 
785                 790                 795                 800 


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
                805                 810                 815     


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
            820                 825                 830         


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
        835                 840                 845             


Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala 
    850                 855                 860                 


Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe 
865                 870                 875                 880 


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
                885                 890                 895     


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
            900                 905                 910         


Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
        915                 920                 925             


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
    930                 935                 940                 


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys 
945                 950                 955                 960 


Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln 
                965                 970                 975     


Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile 
            980                 985                 990         


Arg Ala Ser Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
        995                 1000                 1005             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1010                 1015                 1020             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1025                 1030                 1035             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1040                 1045                 1050             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1055                 1060                 1065             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1070                 1075                 1080             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1085                 1090                 1095             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1100                 1105                 1110             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1115                 1120                 1125             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1130                 1135                 1140             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1145                 1150                 1155             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1160                 1165                 1170             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln 
    1175                 1180         


<210>  12
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5P_USEO4

<400>  12

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Pro Gly Pro Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln 
    1175                 1180                 


<210>  13
<211>  1188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 5P_USEO5

<400>  13

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Gly Gly Ser Ser Ser Ile 
            660                 665                 670         


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
        675                 680                 685             


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
    690                 695                 700                 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
705                 710                 715                 720 


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
                725                 730                 735     


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
            740                 745                 750         


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
        755                 760                 765             


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
    770                 775                 780                 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp 
785                 790                 795                 800 


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
                805                 810                 815     


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
            820                 825                 830         


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
        835                 840                 845             


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
    850                 855                 860                 


Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met 
865                 870                 875                 880 


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
                885                 890                 895     


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
            900                 905                 910         


Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu 
        915                 920                 925             


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
    930                 935                 940                 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
945                 950                 955                 960 


Leu Ser Arg Leu Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu 
                965                 970                 975     


Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu 
            980                 985                 990         


Ile Arg Ala Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
        995                 1000                 1005             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1010                 1015                 1020             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1025                 1030                 1035             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1055                 1060                 1065             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1070                 1075                 1080             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1085                 1090                 1095             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1100                 1105                 1110             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1115                 1120                 1125             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1130                 1135                 1140             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1145                 1150                 1155             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1160                 1165                 1170             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1175                 1180                 1185             


<210>  14
<211>  1188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO5_5P_DS3

<400>  14

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Gly Gly Gly Ser Ser Ile 
            660                 665                 670         


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser 
        675                 680                 685             


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
    690                 695                 700                 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
705                 710                 715                 720 


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
                725                 730                 735     


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
            740                 745                 750         


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
        755                 760                 765             


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
    770                 775                 780                 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp 
785                 790                 795                 800 


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
                805                 810                 815     


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
            820                 825                 830         


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
        835                 840                 845             


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser 
    850                 855                 860                 


Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met 
865                 870                 875                 880 


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
                885                 890                 895     


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
            900                 905                 910         


Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu 
        915                 920                 925             


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
    930                 935                 940                 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
945                 950                 955                 960 


Leu Ser Arg Leu Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu 
                965                 970                 975     


Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu 
            980                 985                 990         


Ile Arg Ala Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
        995                 1000                 1005             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1010                 1015                 1020             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1025                 1030                 1035             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1055                 1060                 1065             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1070                 1075                 1080             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1085                 1090                 1095             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1100                 1105                 1110             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1115                 1120                 1125             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1130                 1135                 1140             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1145                 1150                 1155             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1160                 1165                 1170             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1175                 1180                 1185             


<210>  15
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO1_5P_DS3

<400>  15

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln 
    1175                 1180                 


<210>  16
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO4_5P_DS3

<400>  16

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Pro Gly Pro Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln 
    1175                 1180                 


<210>  17
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: PentaPro_D614G

<400>  17

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
        675                 680                 685             


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  
    1190                 1195 


<210>  18
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO1_5P_DS3_D614G

<400>  18

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln 
    1175                 1180                 


<210>  19
<211>  1182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO3_5P_DS3_D614G

<400>  19

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Pro Ser Ile Ile Ala Tyr Thr Met Ser 
            660                 665                 670         


Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile Ala Ile 
        675                 680                 685             


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
    690                 695                 700                 


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
705                 710                 715                 720 


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
                725                 730                 735     


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
            740                 745                 750         


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
        755                 760                 765             


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
    770                 775                 780                 


Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val 
785                 790                 795                 800 


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
                805                 810                 815     


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
            820                 825                 830         


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
        835                 840                 845             


Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe Gly Ala 
    850                 855                 860                 


Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe 
865                 870                 875                 880 


Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu 
                885                 890                 895     


Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu 
            900                 905                 910         


Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln 
        915                 920                 925             


Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe 
    930                 935                 940                 


Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys 
945                 950                 955                 960 


Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln 
                965                 970                 975     


Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile 
            980                 985                 990         


Arg Ala Ser Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
        995                 1000                 1005             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1010                 1015                 1020             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1025                 1030                 1035             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1040                 1045                 1050             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1055                 1060                 1065             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1070                 1075                 1080             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1085                 1090                 1095             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1100                 1105                 1110             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1115                 1120                 1125             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1130                 1135                 1140             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1145                 1150                 1155             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1160                 1165                 1170             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln 
    1175                 1180         


<210>  20
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO5_5P_DS3_D614G

<400>  20

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Pro Gly Pro Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln 
    1175                 1180                 


<210>  21
<211>  1188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO5_5P_DS3_D614G

<400>  21

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Gly Gly Gly Ser Ser Ile 
            660                 665                 670         


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser 
        675                 680                 685             


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
    690                 695                 700                 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
705                 710                 715                 720 


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
                725                 730                 735     


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
            740                 745                 750         


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
        755                 760                 765             


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
    770                 775                 780                 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp 
785                 790                 795                 800 


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
                805                 810                 815     


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
            820                 825                 830         


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
        835                 840                 845             


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser 
    850                 855                 860                 


Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met 
865                 870                 875                 880 


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
                885                 890                 895     


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
            900                 905                 910         


Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu 
        915                 920                 925             


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
    930                 935                 940                 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
945                 950                 955                 960 


Leu Ser Arg Leu Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu 
                965                 970                 975     


Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu 
            980                 985                 990         


Ile Arg Ala Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
        995                 1000                 1005             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1010                 1015                 1020             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1025                 1030                 1035             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1055                 1060                 1065             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1070                 1075                 1080             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1085                 1090                 1095             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1100                 1105                 1110             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1115                 1120                 1125             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1130                 1135                 1140             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1145                 1150                 1155             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1160                 1165                 1170             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1175                 1180                 1185             


<210>  22
<211>  1188
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO5_5P_DS2

<400>  22

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Cys 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Gly Ser Gly Gly Ser Ser Ser Ile 
            660                 665                 670         


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
        675                 680                 685             


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
    690                 695                 700                 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
705                 710                 715                 720 


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
                725                 730                 735     


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
            740                 745                 750         


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
        755                 760                 765             


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
    770                 775                 780                 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp 
785                 790                 795                 800 


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
                805                 810                 815     


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
            820                 825                 830         


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
        835                 840                 845             


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
    850                 855                 860                 


Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met 
865                 870                 875                 880 


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
                885                 890                 895     


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
            900                 905                 910         


Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu 
        915                 920                 925             


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
    930                 935                 940                 


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
945                 950                 955                 960 


Leu Ser Arg Leu Asp Cys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu 
                965                 970                 975     


Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu 
            980                 985                 990         


Ile Arg Ala Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
        995                 1000                 1005             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1010                 1015                 1020             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1025                 1030                 1035             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1040                 1045                 1050             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1055                 1060                 1065             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1070                 1075                 1080             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1085                 1090                 1095             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1100                 1105                 1110             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1115                 1120                 1125             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1130                 1135                 1140             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1145                 1150                 1155             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1160                 1165                 1170             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1175                 1180                 1185             


<210>  23
<211>  1254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: SARS-CoV-2 "spike" with the VFLIP technology and the 
       mutations contained in the South African variant

<400>  23

Gln Cys Val Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Ala Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Gly Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
225                 230                 235                 240 


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
                245                 250                 255     


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
            260                 265                 270         


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
        275                 280                 285             


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
    290                 295                 300                 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
305                 310                 315                 320 


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
                325                 330                 335     


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
            340                 345                 350         


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
        355                 360                 365             


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
    370                 375                 380                 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
385                 390                 395                 400 


Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
                405                 410                 415     


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
            420                 425                 430         


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
        435                 440                 445             


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
    450                 455                 460                 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
465                 470                 475                 480 


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
                485                 490                 495     


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
            500                 505                 510         


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
        515                 520                 525             


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
    530                 535                 540                 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
545                 550                 555                 560 


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
                565                 570                 575     


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
            580                 585                 590         


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
        595                 600                 605             


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
    610                 615                 620                 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
625                 630                 635                 640 


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
                645                 650                 655     


Ser Tyr Gln Gly Gly Gly Ser Gly Gly Ser Ser Ile Ile Ala Tyr Thr 
            660                 665                 670         


Met Ser Leu Gly Val Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile 
        675                 680                 685             


Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro 
    690                 695                 700                 


Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly 
705                 710                 715                 720 


Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys 
                725                 730                 735     


Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys 
            740                 745                 750         


Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro 
        755                 760                 765             


Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp 
    770                 775                 780                 


Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn 
785                 790                 795                 800 


Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys 
                805                 810                 815     


Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn 
            820                 825                 830         


Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln 
        835                 840                 845             


Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe 
    850                 855                 860                 


Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr 
865                 870                 875                 880 


Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln 
                885                 890                 895     


Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp 
            900                 905                 910         


Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val 
        915                 920                 925             


Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser 
    930                 935                 940                 


Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu 
945                 950                 955                 960 


Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg 
                965                 970                 975     


Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala 
            980                 985                 990         


Glu Ile Arg Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
        995                 1000                 1005             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1010                 1015                 1020             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1025                 1030                 1035             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1040                 1045                 1050             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1055                 1060                 1065             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1070                 1075                 1080             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1085                 1090                 1095             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1100                 1105                 1110             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1115                 1120                 1125             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1130                 1135                 1140             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1145                 1150                 1155             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1160                 1165                 1170             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Gly 
    1175                 1180                 1185             


Ser Gly  Tyr Ile Pro Glu Ala  Pro Arg Asp Gly Gln  Ala Tyr Val 
    1190                 1195                 1200             


Arg Lys  Asp Gly Glu Trp Val  Leu Leu Ser Thr Phe  Leu Leu Glu 
    1205                 1210                 1215             


Val Leu  Phe Gln Gly Pro Ala  Gly Trp Ser His Pro  Gln Phe Glu 
    1220                 1225                 1230             


Lys Gly  Gly Gly Ser Gly Gly  Gly Ser Gly Gly Gly  Ser Trp Ser 
    1235                 1240                 1245             


His Pro  Gln Phe Glu Lys 
    1250                 


<210>  24
<211>  1031
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: SARS1_VFLIP

<400>  24

Ser Asp Leu Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn 
1               5                   10                  15      


Tyr Thr Gln His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu 
            20                  25                  30          


Ile Phe Arg Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro 
        35                  40                  45              


Phe Tyr Ser Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Asp 
    50                  55                  60                  


Asn Pro Val Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu 
65                  70                  75                  80  


Lys Ser Asn Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn 
                85                  90                  95      


Lys Ser Gln Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile 
            100                 105                 110         


Arg Ala Cys Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser 
        115                 120                 125             


Lys Pro Met Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe 
    130                 135                 140                 


Asn Cys Thr Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser 
145                 150                 155                 160 


Glu Lys Ser Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn 
                165                 170                 175     


Lys Asp Gly Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val 
            180                 185                 190         


Val Arg Asp Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys 
        195                 200                 205             


Leu Pro Leu Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala 
    210                 215                 220                 


Phe Ser Pro Ala Gln Asp Thr Trp Gly Thr Ser Ala Ala Ala Tyr Phe 
225                 230                 235                 240 


Val Gly Tyr Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn 
                245                 250                 255     


Gly Thr Ile Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu 
            260                 265                 270         


Leu Lys Cys Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln 
        275                 280                 285             


Thr Ser Asn Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro 
    290                 295                 300                 


Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys 
305                 310                 315                 320 


Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val 
                325                 330                 335     


Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys 
            340                 345                 350         


Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn 
        355                 360                 365             


Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile 
    370                 375                 380                 


Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro 
385                 390                 395                 400 


Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp 
                405                 410                 415     


Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His 
            420                 425                 430         


Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser 
        435                 440                 445             


Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro 
    450                 455                 460                 


Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro 
465                 470                 475                 480 


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr 
                485                 490                 495     


Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val 
            500                 505                 510         


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser 
        515                 520                 525             


Ser Lys Arg Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp 
    530                 535                 540                 


Phe Thr Asp Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile 
545                 550                 555                 560 


Ser Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
                565                 570                 575     


Ala Ser Ser Glu Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Asp 
            580                 585                 590         


Val Ser Thr Ala Ile His Ala Asp Gln Leu Thr Pro Ala Trp Arg Ile 
        595                 600                 605             


Tyr Ser Thr Gly Asn Asn Val Phe Gln Thr Gln Ala Gly Cys Leu Ile 
    610                 615                 620                 


Gly Ala Glu His Val Asp Thr Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
625                 630                 635                 640 


Ala Gly Ile Cys Ala Ser Tyr His Gly Gly Ser Gly Gly Ser Ser Ile 
                645                 650                 655     


Val Ala Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Cys Ser 
            660                 665                 670         


Asn Asn Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr 
        675                 680                 685             


Glu Val Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys Asn Met 
    690                 695                 700                 


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu Gln Tyr 
705                 710                 715                 720 


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile Ala Ala 
                725                 730                 735     


Glu Gln Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys Gln Met 
            740                 745                 750         


Tyr Lys Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln 
        755                 760                 765             


Ile Leu Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Pro Ile Glu Asp 
    770                 775                 780                 


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln 
785                 790                 795                 800 


Tyr Gly Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile Cys Ala 
                805                 810                 815     


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp 
            820                 825                 830         


Met Ile Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Cys Ala 
        835                 840                 845             


Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met 
    850                 855                 860                 


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
865                 870                 875                 880 


Tyr Glu Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala Ile Ser 
                885                 890                 895     


Gln Ile Gln Glu Ser Leu Thr Thr Thr Pro Thr Ala Leu Gly Lys Leu 
            900                 905                 910         


Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys 
        915                 920                 925             


Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile 
    930                 935                 940                 


Leu Ser Arg Leu Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu 
945                 950                 955                 960 


Ile Tyr Ile Lys Gly Ser Gly Tyr Ile Pro Glu Ala Pro Arg Asp Gly 
                965                 970                 975     


Gln Ala Tyr Val Arg Lys Asp Gly Glu Trp Val Leu Leu Ser Thr Phe 
            980                 985                 990         


Leu Leu Glu Val Leu Phe Gln Gly  Pro Ala Gly Trp Ser  His Pro Gln 
        995                 1000                 1005             


Phe Glu  Lys Gly Gly Gly Ser  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1010                 1015                 1020             


Trp Ser  His Pro Gln Phe Glu  Lys 
    1025                 1030     


<210>  25
<211>  1114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: MERS_VFLIP

<400>  25

Tyr Val Asp Val Gly Pro Asp Ser Val Lys Ser Ala Cys Ile Glu Val 
1               5                   10                  15      


Asp Ile Gln Gln Thr Phe Phe Asp Lys Thr Trp Pro Arg Pro Ile Asp 
            20                  25                  30          


Val Ser Lys Ala Asp Gly Ile Ile Tyr Pro Gln Gly Arg Thr Tyr Ser 
        35                  40                  45              


Asn Ile Thr Ile Thr Tyr Gln Gly Leu Phe Pro Tyr Gln Gly Asp His 
    50                  55                  60                  


Gly Asp Met Tyr Val Tyr Ser Ala Gly His Ala Thr Gly Thr Thr Pro 
65                  70                  75                  80  


Gln Lys Leu Phe Val Ala Asn Tyr Ser Gln Asp Val Lys Gln Phe Ala 
                85                  90                  95      


Asn Gly Phe Val Val Arg Ile Gly Ala Ala Ala Asn Ser Thr Gly Thr 
            100                 105                 110         


Val Ile Ile Ser Pro Ser Thr Ser Ala Thr Ile Arg Lys Ile Tyr Pro 
        115                 120                 125             


Ala Phe Met Leu Gly Ser Ser Val Gly Asn Phe Ser Asp Gly Lys Met 
    130                 135                 140                 


Gly Arg Phe Phe Asn His Thr Leu Val Leu Leu Pro Asp Gly Cys Gly 
145                 150                 155                 160 


Thr Leu Leu Arg Ala Phe Tyr Cys Ile Leu Glu Pro Arg Ser Gly Asn 
                165                 170                 175     


His Cys Pro Ala Gly Asn Ser Tyr Thr Ser Phe Ala Thr Tyr His Thr 
            180                 185                 190         


Pro Ala Thr Asp Cys Ser Asp Gly Asn Tyr Asn Arg Asn Ala Ser Leu 
        195                 200                 205             


Asn Ser Phe Lys Glu Tyr Phe Asn Leu Arg Asn Cys Thr Phe Met Tyr 
    210                 215                 220                 


Thr Tyr Asn Ile Thr Glu Asp Glu Ile Leu Glu Trp Phe Gly Ile Thr 
225                 230                 235                 240 


Gln Thr Ala Gln Gly Val His Leu Phe Ser Ser Arg Tyr Val Asp Leu 
                245                 250                 255     


Tyr Gly Gly Asn Met Phe Gln Phe Ala Thr Leu Pro Val Tyr Asp Thr 
            260                 265                 270         


Ile Lys Tyr Tyr Ser Ile Ile Pro His Ser Ile Arg Ser Ile Gln Ser 
        275                 280                 285             


Asp Arg Lys Ala Trp Ala Ala Phe Tyr Val Tyr Lys Leu Gln Pro Leu 
    290                 295                 300                 


Thr Phe Leu Leu Asp Phe Ser Val Asp Gly Tyr Ile Arg Arg Ala Ile 
305                 310                 315                 320 


Asp Cys Gly Phe Asn Asp Leu Ser Gln Leu His Cys Ser Tyr Glu Ser 
                325                 330                 335     


Phe Asp Val Glu Ser Gly Val Tyr Ser Val Ser Ser Phe Glu Ala Lys 
            340                 345                 350         


Pro Ser Gly Ser Val Val Glu Gln Ala Glu Gly Val Glu Cys Asp Phe 
        355                 360                 365             


Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg 
    370                 375                 380                 


Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu 
385                 390                 395                 400 


Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile 
                405                 410                 415     


Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro 
            420                 425                 430         


Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly Pro Ile Ser 
        435                 440                 445             


Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu 
    450                 455                 460                 


Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr 
465                 470                 475                 480 


Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp Arg Thr Glu 
                485                 490                 495     


Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile 
            500                 505                 510         


Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu 
        515                 520                 525             


Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly Ser Thr Val 
    530                 535                 540                 


Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr Val Gln Tyr 
545                 550                 555                 560 


Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Glu Phe Ala Asn Asp 
                565                 570                 575     


Thr Lys Ile Ala Ser Gln Leu Gly Asn Cys Val Glu Tyr Ser Leu Tyr 
            580                 585                 590         


Gly Val Ser Gly Arg Gly Val Phe Gln Asn Cys Thr Ala Val Gly Val 
        595                 600                 605             


Arg Gln Gln Arg Phe Val Tyr Asp Ala Tyr Gln Asn Leu Val Gly Tyr 
    610                 615                 620                 


Tyr Ser Asp Asp Gly Asn Tyr Tyr Cys Leu Arg Ala Cys Val Ser Val 
625                 630                 635                 640 


Pro Val Ser Val Ile Tyr Asp Lys Glu Thr Lys Thr His Ala Thr Leu 
                645                 650                 655     


Phe Gly Ser Val Ala Cys Glu His Ile Ser Ser Thr Met Ser Gln Tyr 
            660                 665                 670         


Ser Arg Ser Thr Arg Ser Met Leu Lys Arg Arg Asp Ser Thr Tyr Gly 
        675                 680                 685             


Pro Leu Gln Thr Pro Val Gly Cys Val Leu Gly Leu Val Asn Ser Ser 
    690                 695                 700                 


Leu Phe Val Glu Asp Cys Lys Leu Pro Leu Gly Gln Ser Leu Cys Ala 
705                 710                 715                 720 


Leu Pro Asp Gly Gly Ser Gly Gly Ser Met Arg Leu Ala Ser Ile Ala 
                725                 730                 735     


Phe Asn His Pro Ile Gln Val Asp Gln Leu Asn Ser Ser Tyr Phe Lys 
            740                 745                 750         


Cys Ser Ile Pro Thr Asn Phe Ser Phe Gly Val Thr Gln Glu Tyr Ile 
        755                 760                 765             


Gln Thr Thr Ile Gln Lys Val Thr Val Asp Cys Lys Gln Tyr Val Cys 
    770                 775                 780                 


Asn Gly Phe Gln Lys Cys Glu Gln Leu Leu Arg Glu Tyr Gly Gln Phe 
785                 790                 795                 800 


Cys Ser Lys Ile Asn Gln Ala Leu His Gly Ala Asn Leu Arg Gln Asp 
                805                 810                 815     


Asp Ser Val Arg Asn Leu Phe Ala Ser Val Lys Ser Ser Gln Ser Ser 
            820                 825                 830         


Pro Ile Ile Pro Gly Phe Gly Gly Asp Phe Asn Leu Thr Leu Leu Glu 
        835                 840                 845             


Pro Val Ser Ile Ser Thr Gly Ser Arg Ser Ala Arg Ser Pro Ile Glu 
    850                 855                 860                 


Asp Leu Leu Phe Asp Lys Val Thr Ile Ala Asp Pro Gly Tyr Met Gln 
865                 870                 875                 880 


Gly Tyr Asp Asp Cys Met Gln Gln Gly Pro Ala Ser Ala Arg Asp Leu 
                885                 890                 895     


Ile Cys Ala Gln Tyr Val Ala Gly Tyr Lys Val Leu Pro Pro Leu Met 
            900                 905                 910         


Asp Val Asn Met Glu Ala Ala Tyr Thr Ser Ser Leu Leu Gly Ser Ile 
        915                 920                 925             


Ala Gly Val Gly Trp Thr Ala Gly Leu Ser Pro Phe Cys Ala Ile Pro 
    930                 935                 940                 


Phe Pro Gln Ser Ile Phe Tyr Arg Leu Asn Gly Val Gly Ile Thr Gln 
945                 950                 955                 960 


Gln Val Leu Ser Glu Asn Gln Lys Leu Ile Ala Asn Lys Phe Asn Gln 
                965                 970                 975     


Ala Leu Gly Ala Met Gln Thr Gly Phe Thr Thr Thr Pro Glu Ala Phe 
            980                 985                 990         


Gln Lys Val Gln Asp Ala Val Asn  Asn Asn Ala Gln Ala  Leu Ser Lys 
        995                 1000                 1005             


Leu Ala  Ser Glu Leu Ser Asn  Thr Phe Gly Ala Ile  Ser Ala Ser 
    1010                 1015                 1020             


Ile Gly  Asp Ile Ile Gln Arg  Leu Asp Val Pro Glu  Gln Asp Ala 
    1025                 1030                 1035             


Gln Ile  Asp Arg Leu Ile Tyr  Ile Lys Gly Ser Gly  Tyr Ile Pro 
    1040                 1045                 1050             


Glu Ala  Pro Arg Asp Gly Gln  Ala Tyr Val Arg Lys  Asp Gly Glu 
    1055                 1060                 1065             


Trp Val  Leu Leu Ser Thr Phe  Leu Leu Glu Val Leu  Phe Gln Gly 
    1070                 1075                 1080             


Pro Ala  Gly Trp Ser His Pro  Gln Phe Glu Lys Gly  Gly Gly Ser 
    1085                 1090                 1095             


Gly Gly  Gly Ser Gly Gly Gly  Ser Trp Ser His Pro  Gln Phe Glu 
    1100                 1105                 1110             


Lys 
    


<210>  26
<211>  1195
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Hexa_DS1

<400>  26

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Cys Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Cys Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser 
            660                 665                 670         


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
        675                 680                 685             


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
    690                 695                 700                 


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
705                 710                 715                 720 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
                725                 730                 735     


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
            740                 745                 750         


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
        755                 760                 765             


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
    770                 775                 780                 


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
785                 790                 795                 800 


Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
                805                 810                 815     


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
            820                 825                 830         


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
        835                 840                 845             


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
    850                 855                 860                 


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala 
865                 870                 875                 880 


Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
                885                 890                 895     


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
            900                 905                 910         


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
        915                 920                 925             


Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
    930                 935                 940                 


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
945                 950                 955                 960 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
                965                 970                 975     


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
            980                 985                 990         


Thr Tyr Val Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
        995                 1000                 1005             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1010                 1015                 1020             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1025                 1030                 1035             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1040                 1045                 1050             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1055                 1060                 1065             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1070                 1075                 1080             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1085                 1090                 1095             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1100                 1105                 1110             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1115                 1120                 1125             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1130                 1135                 1140             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1145                 1150                 1155             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1160                 1165                 1170             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1175                 1180                 1185             


Glu Leu  Gly Lys Tyr Glu Gln  
    1190                 1195 


<210>  27
<211>  1317
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: OC43_VFLIP

<400>  27

Met Pro Met Gly Ser Leu Gln Pro Leu Ala Thr Leu Tyr Leu Leu Gly 
1               5                   10                  15      


Met Leu Val Ala Ser Val Leu Ala Val Ile Gly Asp Leu Lys Cys Thr 
            20                  25                  30          


Ser Asp Asn Ile Asn Asp Lys Asp Thr Gly Pro Pro Pro Ile Ser Thr 
        35                  40                  45              


Asp Thr Val Asp Val Thr Asn Gly Leu Gly Thr Tyr Tyr Val Leu Asp 
    50                  55                  60                  


Arg Val Tyr Leu Asn Thr Thr Leu Phe Leu Asn Gly Tyr Tyr Pro Thr 
65                  70                  75                  80  


Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu Lys Gly Ser Val Leu Leu 
                85                  90                  95      


Ser Arg Leu Trp Phe Lys Pro Pro Phe Leu Ser Asp Phe Ile Asn Gly 
            100                 105                 110         


Ile Phe Ala Lys Val Lys Asn Thr Lys Val Ile Lys Asp Arg Val Met 
        115                 120                 125             


Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly Ser Thr Phe Val Asn Thr 
    130                 135                 140                 


Ser Tyr Ser Val Val Val Gln Pro Arg Thr Ile Asn Ser Thr Gln Asp 
145                 150                 155                 160 


Gly Asp Asn Lys Leu Gln Gly Leu Leu Glu Val Ser Val Cys Gln Tyr 
                165                 170                 175     


Asn Met Cys Glu Tyr Pro Gln Thr Ile Cys His Pro Asn Leu Gly Asn 
            180                 185                 190         


His Arg Lys Glu Leu Trp His Leu Asp Thr Gly Val Val Ser Cys Leu 
        195                 200                 205             


Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn Ala Asp Tyr Leu Tyr Phe 
    210                 215                 220                 


His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr Ala Tyr Phe Thr Asp Thr 
225                 230                 235                 240 


Gly Val Val Thr Lys Phe Leu Phe Asn Val Tyr Leu Gly Met Ala Leu 
                245                 250                 255     


Ser His Tyr Tyr Val Met Pro Leu Thr Cys Asn Ser Lys Leu Thr Leu 
            260                 265                 270         


Glu Tyr Trp Val Thr Pro Leu Thr Ser Arg Gln Tyr Leu Leu Ala Phe 
        275                 280                 285             


Asn Gln Asp Gly Ile Ile Phe Asn Ala Val Asp Cys Met Ser Asp Phe 
    290                 295                 300                 


Met Ser Glu Ile Lys Cys Lys Thr Gln Ser Ile Ala Pro Pro Thr Gly 
305                 310                 315                 320 


Val Tyr Glu Leu Asn Gly Tyr Thr Val Gln Pro Ile Ala Asp Val Tyr 
                325                 330                 335     


Arg Arg Lys Pro Asn Leu Pro Asn Cys Asn Ile Glu Ala Trp Leu Asn 
            340                 345                 350         


Asp Lys Ser Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Thr Phe Ser 
        355                 360                 365             


Asn Cys Asn Phe Asn Met Ser Ser Leu Met Ser Phe Ile Gln Ala Asp 
    370                 375                 380                 


Ser Phe Thr Cys Asn Asn Ile Asp Ala Ala Lys Ile Tyr Gly Met Cys 
385                 390                 395                 400 


Phe Ser Ser Ile Thr Ile Asp Lys Phe Ala Ile Pro Asn Gly Arg Lys 
                405                 410                 415     


Val Asp Leu Gln Leu Gly Asn Leu Gly Tyr Leu Gln Ser Phe Asn Tyr 
            420                 425                 430         


Arg Ile Asp Thr Thr Ala Thr Ser Cys Gln Leu Tyr Tyr Asn Leu Pro 
        435                 440                 445             


Ala Ala Asn Val Ser Val Ser Arg Phe Asn Pro Ser Thr Trp Asn Lys 
    450                 455                 460                 


Arg Phe Gly Phe Ile Glu Asp Ser Val Phe Lys Pro Arg Pro Ala Gly 
465                 470                 475                 480 


Val Leu Thr Asn His Asp Val Val Tyr Ala Gln His Cys Phe Lys Ala 
                485                 490                 495     


Pro Lys Asn Phe Cys Pro Cys Lys Leu Asn Gly Ser Cys Val Gly Ser 
            500                 505                 510         


Gly Pro Gly Lys Asn Asn Gly Ile Gly Thr Cys Pro Ala Gly Thr Asn 
        515                 520                 525             


Tyr Leu Thr Cys Asp Asn Leu Cys Thr Pro Asp Pro Ile Thr Phe Thr 
    530                 535                 540                 


Gly Thr Tyr Lys Cys Pro Gln Thr Lys Ser Leu Val Gly Ile Gly Glu 
545                 550                 555                 560 


His Cys Ser Gly Leu Ala Val Lys Ser Asp Tyr Cys Gly Gly Asn Ser 
                565                 570                 575     


Cys Thr Cys Arg Pro Gln Ala Phe Leu Gly Trp Ser Ala Asp Ser Cys 
            580                 585                 590         


Leu Gln Gly Asp Lys Cys Asn Ile Phe Ala Asn Phe Ile Leu His Asp 
        595                 600                 605             


Val Asn Ser Gly Leu Thr Cys Ser Thr Asp Leu Gln Lys Ala Asn Thr 
    610                 615                 620                 


Asp Ile Ile Leu Gly Val Cys Val Asn Tyr Asp Leu Tyr Gly Ile Leu 
625                 630                 635                 640 


Gly Gln Gly Ile Phe Val Glu Val Asn Ala Thr Tyr Tyr Asn Ser Trp 
                645                 650                 655     


Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn Leu Tyr Gly Phe Arg Asp 
            660                 665                 670         


Tyr Ile Thr Asn Arg Thr Phe Met Ile Arg Ser Cys Tyr Ser Gly Arg 
        675                 680                 685             


Val Ser Ala Ala Phe His Ala Asn Ser Ser Glu Pro Ala Leu Leu Phe 
    690                 695                 700                 


Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn Asn Ser Leu Thr Arg Gln 
705                 710                 715                 720 


Leu Gln Pro Ile Asn Tyr Phe Asp Ser Tyr Leu Gly Cys Val Val Asn 
                725                 730                 735     


Ala Tyr Asn Ser Thr Ala Ile Ser Val Gln Thr Cys Asp Leu Thr Val 
            740                 745                 750         


Gly Ser Gly Tyr Cys Val Asp Tyr Ser Gly Gly Ser Gly Gly Ser Gly 
        755                 760                 765             


Tyr Arg Phe Thr Asn Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp 
    770                 775                 780                 


Ser Cys Glu Pro Val Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu 
785                 790                 795                 800 


Phe Thr Ile Gly Asn Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys 
                805                 810                 815     


Val Thr Ile Asp Cys Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys 
            820                 825                 830         


Lys Ser Gln Leu Val Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala 
        835                 840                 845             


Ile Leu Thr Glu Val Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val 
    850                 855                 860                 


Ala Asn Ser Leu Met Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp 
865                 870                 875                 880 


Gly Val Asn Phe Asn Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly 
                885                 890                 895     


Cys Leu Gly Ser Glu Cys Ser Lys Ala Ser Ser Arg Ser Pro Ile Glu 
            900                 905                 910         


Asp Leu Leu Phe Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu 
        915                 920                 925             


Ala Tyr Asn Asn Cys Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys 
    930                 935                 940                 


Val Gln Ser Tyr Lys Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Gly Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe 
                965                 970                 975     


Cys Pro Trp Thr Pro Ala Ala Gly Val Pro Phe Pro Leu Asn Val Gln 
            980                 985                 990         


Tyr Arg Ile Asn Gly Leu Gly Val  Thr Met Asp Val Leu  Ser Gln Asn 
        995                 1000                 1005             


Gln Lys  Leu Ile Ala Asn Ala  Phe Asn Asn Ala Leu  Tyr Ala Ile 
    1010                 1015                 1020             


Gln Glu  Gly Phe Asp Ala Thr  Pro Ser Ala Leu Val  Lys Ile Gln 
    1025                 1030                 1035             


Ala Val  Val Asn Ala Asn Ala  Glu Ala Leu Asn Asn  Leu Leu Gln 
    1040                 1045                 1050             


Gln Leu  Ser Asn Arg Phe Gly  Ala Ile Ser Ala Ser  Leu Gln Glu 
    1055                 1060                 1065             


Ile Leu  Ser Arg Leu Asp Ala  Pro Glu Ala Glu Ala  Gln Ile Asp 
    1070                 1075                 1080             


Arg Leu  Ile Asn Gly Arg Leu  Thr Ala Leu Asn Ala  Tyr Val Ser 
    1085                 1090                 1095             


Gln Gln  Leu Ser Asp Ser Thr  Leu Val Lys Phe Ser  Ala Ala Gln 
    1100                 1105                 1110             


Ala Met  Glu Lys Val Asn Glu  Cys Val Lys Ser Gln  Ser Ser Arg 
    1115                 1120                 1125             


Ile Asn  Phe Cys Gly Asn Gly  Asn His Ile Ile Ser  Leu Val Gln 
    1130                 1135                 1140             


Asn Ala  Pro Tyr Gly Leu Tyr  Phe Ile His Phe Ser  Tyr Val Pro 
    1145                 1150                 1155             


Thr Lys  Tyr Val Thr Ala Arg  Val Ser Pro Gly Leu  Cys Ile Ala 
    1160                 1165                 1170             


Gly Asp  Arg Gly Ile Ala Pro  Lys Ser Gly Tyr Phe  Val Asn Val 
    1175                 1180                 1185             


Asn Asn  Thr Trp Met Tyr Thr  Gly Ser Gly Tyr Tyr  Tyr Pro Glu 
    1190                 1195                 1200             


Pro Ile  Thr Glu Asn Asn Val  Val Val Met Ser Thr  Cys Ala Val 
    1205                 1210                 1215             


Asn Tyr  Thr Lys Ala Pro Tyr  Val Met Leu Asn Thr  Ser Ile Pro 
    1220                 1225                 1230             


Asn Leu  Pro Asp Phe Lys Glu  Glu Leu Asp Gln Trp  Phe Lys Asn 
    1235                 1240                 1245             


Gln Thr  Ser Val Ala Pro Asp  Leu Ser Leu Asp Tyr  Ile Asn Val 
    1250                 1255                 1260             


Thr Phe  Leu Asp Leu Leu Ile  Lys Arg Met Lys Gln  Ile Glu Asp 
    1265                 1270                 1275             


Lys Ile  Glu Glu Ile Glu Ser  Lys Gln Lys Lys Ile  Glu Asn Glu 
    1280                 1285                 1290             


Ile Ala  Arg Ile Lys Lys Ile  Lys Leu Val Pro Arg  Gly Ser Leu 
    1295                 1300                 1305             


Glu Trp  Ser His Pro Gln Phe  Glu Lys 
    1310                 1315         


<210>  28
<211>  1343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VFLIP_RBD:SARS1_HT-A

<400>  28

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
        515                 520                 525             


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
    530                 535                 540                 


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
545                 550                 555                 560 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
                565                 570                 575     


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
            580                 585                 590         


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
        595                 600                 605             


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
    610                 615                 620                 


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
625                 630                 635                 640 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
                645                 650                 655     


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
            660                 665                 670         


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
        675                 680                 685             


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
    690                 695                 700                 


Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val 
705                 710                 715                 720 


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
                725                 730                 735     


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
            740                 745                 750         


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
        755                 760                 765             


Gly Ile Cys Ala Ser Tyr Gln Gly Gly Ser Gly Gly Ser Ser Ile Ile 
    770                 775                 780                 


Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn 
785                 790                 795                 800 


Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu 
                805                 810                 815     


Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr 
            820                 825                 830         


Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly 
        835                 840                 845             


Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu 
    850                 855                 860                 


Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr 
865                 870                 875                 880 


Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile 
                885                 890                 895     


Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu 
            900                 905                 910         


Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr 
        915                 920                 925             


Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln 
    930                 935                 940                 


Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met 
945                 950                 955                 960 


Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly 
                965                 970                 975     


Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln 
            980                 985                 990         


Met Ala Tyr Arg Phe Asn Gly Ile  Gly Val Thr Gln Asn  Val Leu Tyr 
        995                 1000                 1005             


Glu Asn  Gln Lys Leu Ile Ala  Asn Gln Phe Asn Ser  Ala Ile Gly 
    1010                 1015                 1020             


Lys Ile  Gln Asp Ser Leu Ser  Ser Thr Pro Ser Ala  Leu Gly Lys 
    1025                 1030                 1035             


Leu Gln  Asp Val Val Asn Gln  Asn Ala Gln Ala Leu  Asn Thr Leu 
    1040                 1045                 1050             


Val Lys  Gln Leu Ser Ser Asn  Phe Gly Ala Ile Ser  Ser Val Leu 
    1055                 1060                 1065             


Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Pro Glu Ala  Glu Val Gln 
    1070                 1075                 1080             


Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln Ser Leu  Gln Thr Tyr 
    1085                 1090                 1095             


Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
    1100                 1105                 1110             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1115                 1120                 1125             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1130                 1135                 1140             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1145                 1150                 1155             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1160                 1165                 1170             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1175                 1180                 1185             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1190                 1195                 1200             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1205                 1210                 1215             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1220                 1225                 1230             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1235                 1240                 1245             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1250                 1255                 1260             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1265                 1270                 1275             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1280                 1285                 1290             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Gly Ser Gly  Ser Ala Ser 
    1295                 1300                 1305             


Gly Ala  Glu Ile Ala Ala Ile  Glu Tyr Glu Gln Ala  Ala Ile Lys 
    1310                 1315                 1320             


Glu Glu  Ile Ala Ala Ile Lys  Asp Lys Ile Ala Ala  Ile Lys Glu 
    1325                 1330                 1335             


Tyr Ile  Ala Ala Ile 
    1340             


<210>  29
<211>  1225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VFLIP_RBD:SARS2_HT-B

<400>  29

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     


Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     


Ile Cys Ala Ser Tyr Gln Gly Gly Ser Gly Gly Ser Ser Ile Ile Ala 
            660                 665                 670         


Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn Asn 
        675                 680                 685             


Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile 
    690                 695                 700                 


Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile 
705                 710                 715                 720 


Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser 
                725                 730                 735     


Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln 
            740                 745                 750         


Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys 
        755                 760                 765             


Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu 
    770                 775                 780                 


Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu 
785                 790                 795                 800 


Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly 
                805                 810                 815     


Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys 
            820                 825                 830         


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile 
        835                 840                 845             


Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp 
    850                 855                 860                 


Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met 
865                 870                 875                 880 


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
                885                 890                 895     


Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile 
            900                 905                 910         


Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asp 
        915                 920                 925             


Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu 
    930                 935                 940                 


Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser 
945                 950                 955                 960 


Arg Leu Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr 
                965                 970                 975     


Gly Arg Leu Gln Ser Leu Gln Thr Tyr Val Thr Gln Gln Leu Ile Arg 
            980                 985                 990         


Ala Ala Glu Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
        995                 1000                 1005             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1010                 1015                 1020             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His Gly Val 
    1025                 1030                 1035             


Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe 
    1040                 1045                 1050             


Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
    1055                 1060                 1065             


Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr 
    1070                 1075                 1080             


Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1085                 1090                 1095             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn 
    1100                 1105                 1110             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1115                 1120                 1125             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1130                 1135                 1140             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1145                 1150                 1155             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1160                 1165                 1170             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Gly Ser 
    1175                 1180                 1185             


Ala Ser  Gly Glu Lys Ile Ala  Ala Ile Lys Glu Glu  Gln Ala Ala 
    1190                 1195                 1200             


Ile Glu  Glu Glu Ile Gln Ala  Ile Lys Glu Glu Ile  Ala Ala Ile 
    1205                 1210                 1215             


Lys Tyr  Leu Ile Ala Gln Ile  
    1220                 1225 


<210>  30
<211>  1354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VFLIP_RBD:MERS_HT-C

<400>  30

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Gly Val Glu 
305                 310                 315                 320 


Cys Asp Phe Ser Pro Leu Leu Ser Gly Thr Pro Pro Gln Val Tyr Asn 
                325                 330                 335     


Phe Lys Arg Leu Val Phe Thr Asn Cys Asn Tyr Asn Leu Thr Lys Leu 
            340                 345                 350         


Leu Ser Leu Phe Ser Val Asn Asp Phe Thr Cys Ser Gln Ile Ser Pro 
        355                 360                 365             


Ala Ala Ile Ala Ser Asn Cys Tyr Ser Ser Leu Ile Leu Asp Tyr Phe 
    370                 375                 380                 


Ser Tyr Pro Leu Ser Met Lys Ser Asp Leu Ser Val Ser Ser Ala Gly 
385                 390                 395                 400 


Pro Ile Ser Gln Phe Asn Tyr Lys Gln Ser Phe Ser Asn Pro Thr Cys 
                405                 410                 415     


Leu Ile Leu Ala Thr Val Pro His Asn Leu Thr Thr Ile Thr Lys Pro 
            420                 425                 430         


Leu Lys Tyr Ser Tyr Ile Asn Lys Cys Ser Arg Leu Leu Ser Asp Asp 
        435                 440                 445             


Arg Thr Glu Val Pro Gln Leu Val Asn Ala Asn Gln Tyr Ser Pro Cys 
    450                 455                 460                 


Val Ser Ile Val Pro Ser Thr Val Trp Glu Asp Gly Asp Tyr Tyr Arg 
465                 470                 475                 480 


Lys Gln Leu Ser Pro Leu Glu Gly Gly Gly Trp Leu Val Ala Ser Gly 
                485                 490                 495     


Ser Thr Val Ala Met Thr Glu Gln Leu Gln Met Gly Phe Gly Ile Thr 
            500                 505                 510         


Val Gln Tyr Gly Thr Asp Thr Asn Ser Val Cys Pro Lys Leu Gly Lys 
        515                 520                 525             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    530                 535                 540                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
545                 550                 555                 560 


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                565                 570                 575     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
            580                 585                 590         


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        595                 600                 605             


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    610                 615                 620                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
625                 630                 635                 640 


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
                645                 650                 655     


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
            660                 665                 670         


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
        675                 680                 685             


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
    690                 695                 700                 


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
705                 710                 715                 720 


Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
                725                 730                 735     


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
            740                 745                 750         


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
        755                 760                 765             


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
    770                 775                 780                 


Tyr Gln Gly Gly Ser Gly Gly Ser Ser Ile Ile Ala Tyr Thr Met Ser 
785                 790                 795                 800 


Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile Ala Ile 
                805                 810                 815     


Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser 
            820                 825                 830         


Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser 
        835                 840                 845             


Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln 
    850                 855                 860                 


Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr 
865                 870                 875                 880 


Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile 
                885                 890                 895     


Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser 
            900                 905                 910         


Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val 
        915                 920                 925             


Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly 
    930                 935                 940                 


Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu 
945                 950                 955                 960 


Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr 
                965                 970                 975     


Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe Gly Ala 
            980                 985                 990         


Gly Pro Ala Leu Gln Ile Pro Phe  Pro Met Gln Met Ala  Tyr Arg Phe 
        995                 1000                 1005             


Asn Gly  Ile Gly Val Thr Gln  Asn Val Leu Tyr Glu  Asn Gln Lys 
    1010                 1015                 1020             


Leu Ile  Ala Asn Gln Phe Asn  Ser Ala Ile Gly Lys  Ile Gln Asp 
    1025                 1030                 1035             


Ser Leu  Ser Ser Thr Pro Ser  Ala Leu Gly Lys Leu  Gln Asp Val 
    1040                 1045                 1050             


Val Asn  Gln Asn Ala Gln Ala  Leu Asn Thr Leu Val  Lys Gln Leu 
    1055                 1060                 1065             


Ser Ser  Asn Phe Gly Ala Ile  Ser Ser Val Leu Asn  Asp Ile Leu 
    1070                 1075                 1080             


Ser Arg  Leu Asp Lys Pro Glu  Ala Glu Val Gln Ile  Asp Arg Leu 
    1085                 1090                 1095             


Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
    1100                 1105                 1110             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1115                 1120                 1125             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1130                 1135                 1140             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1145                 1150                 1155             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1160                 1165                 1170             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1175                 1180                 1185             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1190                 1195                 1200             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1205                 1210                 1215             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1220                 1225                 1230             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1235                 1240                 1245             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1250                 1255                 1260             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1265                 1270                 1275             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1280                 1285                 1290             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1295                 1300                 1305             


Glu Gln  Tyr Ile Lys Gly Ser  Gly Ser Ala Ser Gly  Ala Glu Ile 
    1310                 1315                 1320             


Ala Ala  Ile Lys Tyr Lys Gln  Ala Ala Ile Lys Asn  Glu Ile Ala 
    1325                 1330                 1335             


Ala Ile  Lys Gln Glu Ile Ala  Ala Ile Glu Gln Met  Ile Ala Ala 
    1340                 1345                 1350             


Ile 
    


<210>  31
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: B.1.617.1 (Kappa) VFLIP

<400>  31

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
            20                  25                  30          


Thr Asn Ser Phe Thr Arg Asp Val Tyr Tyr Pro Asp Lys Val Phe Arg 
        35                  40                  45              


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
    50                  55                  60                  


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
65                  70                  75                  80  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
                85                  90                  95      


Ala Ser Ile Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
            100                 105                 110         


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
        115                 120                 125             


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
    130                 135                 140                 


Leu Asp Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Lys Ser Glu 
145                 150                 155                 160 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
                165                 170                 175     


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
        195                 200                 205             


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
    210                 215                 220                 


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
                245                 250                 255     


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
            260                 265                 270         


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
        275                 280                 285             


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
    290                 295                 300                 


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
305                 310                 315                 320 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
                325                 330                 335     


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
            340                 345                 350         


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
        355                 360                 365             


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
    370                 375                 380                 


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
385                 390                 395                 400 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
                405                 410                 415     


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            420                 425                 430         


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
        435                 440                 445             


Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn 
    450                 455                 460                 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asn Gly Val Gln Gly Phe Asn Cys Tyr Phe Pro Leu 
                485                 490                 495     


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
            500                 505                 510         


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
        515                 520                 525             


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
    530                 535                 540                 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
545                 550                 555                 560 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
                565                 570                 575     


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
            580                 585                 590         


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
        595                 600                 605             


Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val 
    610                 615                 620                 


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
625                 630                 635                 640 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
                645                 650                 655     


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
            660                 665                 670         


Gly Ile Cys Ala Ser Tyr Gln Gly Gly Ser Gly Gly Ser Ser Ile Ile 
        675                 680                 685             


Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn 
    690                 695                 700                 


Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu 
705                 710                 715                 720 


Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr 
                725                 730                 735     


Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly 
            740                 745                 750         


Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu 
        755                 760                 765             


Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr 
    770                 775                 780                 


Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile 
785                 790                 795                 800 


Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu 
                805                 810                 815     


Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr 
            820                 825                 830         


Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln 
        835                 840                 845             


Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met 
    850                 855                 860                 


Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly 
865                 870                 875                 880 


Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln 
                885                 890                 895     


Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr 
            900                 905                 910         


Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys 
        915                 920                 925             


Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln 
    930                 935                 940                 


Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln 
945                 950                 955                 960 


Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu 
                965                 970                 975     


Ser Arg Leu Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile 
            980                 985                 990         


Thr Gly Arg Leu Gln Ser Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile 
        995                 1000                 1005             


Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
    1010                 1015                 1020             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1025                 1030                 1035             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1040                 1045                 1050             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  His Glu Lys 
    1055                 1060                 1065             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1070                 1075                 1080             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1085                 1090                 1095             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1100                 1105                 1110             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1115                 1120                 1125             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1130                 1135                 1140             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1145                 1150                 1155             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1160                 1165                 1170             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1175                 1180                 1185             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1190                 1195                 1200             


Tyr Ile  Lys Gly Ser Gly Tyr  Ile Pro Glu Ala Pro  Arg Asp Gly 
    1205                 1210                 1215             


Gln Ala  Tyr Val Arg Lys Asp  Gly Glu Trp Val Leu  Leu Ser Thr 
    1220                 1225                 1230             


Phe Leu  Leu Glu Val Leu Phe  Gln Gly Pro Ala Gly  Trp Ser His 
    1235                 1240                 1245             


Pro Gln  Phe Glu Lys Gly Gly  Gly Ser Gly Gly Gly  Ser Gly Gly 
    1250                 1255                 1260             


Gly Ser  Trp Ser His Pro Gln  Phe Glu Lys 
    1265                 1270             


<210>  32
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: B.1.617.2 (Delta) VFLIP

<400>  32

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala Gln Cys Val Asn Leu Arg Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
            20                  25                  30          


Thr Asn Ser Phe Thr Arg Asp Val Tyr Tyr Pro Asp Lys Val Phe Arg 
        35                  40                  45              


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
    50                  55                  60                  


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
65                  70                  75                  80  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
                85                  90                  95      


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
            100                 105                 110         


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
        115                 120                 125             


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
    130                 135                 140                 


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Gly 
145                 150                 155                 160 


Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro 
                165                 170                 175     


Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg 
            180                 185                 190         


Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys 
        195                 200                 205             


His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala 
    210                 215                 220                 


Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe 
225                 230                 235                 240 


Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser 
                245                 250                 255     


Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu 
            260                 265                 270         


Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr 
        275                 280                 285             


Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
    290                 295                 300                 


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe 
305                 310                 315                 320 


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
                325                 330                 335     


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            340                 345                 350         


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        355                 360                 365             


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    370                 375                 380                 


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
385                 390                 395                 400 


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                405                 410                 415     


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            420                 425                 430         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        435                 440                 445             


Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    450                 455                 460                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Lys 
465                 470                 475                 480 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                485                 490                 495     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            500                 505                 510         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        515                 520                 525             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn 
    530                 535                 540                 


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
545                 550                 555                 560 


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
                565                 570                 575     


Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys 
            580                 585                 590         


Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn 
        595                 600                 605             


Gln Val Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val 
    610                 615                 620                 


Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr 
625                 630                 635                 640 


Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu 
                645                 650                 655     


His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile 
            660                 665                 670         


Cys Ala Ser Tyr Gln Gly Gly Ser Gly Gly Ser Ser Ile Ile Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Cys Ser Asn Asn Ser 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
705                 710                 715                 720 


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
        755                 760                 765             


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
    770                 775                 780                 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Ser Lys Pro Ser Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
            820                 825                 830         


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
    850                 855                 860                 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Pro Ala Leu Gln Ile Pro Phe Pro Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
        915                 920                 925             


Asp Ser Leu Ser Ser Thr Pro Ser Ala Leu Gly Lys Leu Gln Asn Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Lys Pro Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Gly  Ser Gly Tyr Ile Pro  Glu Ala Pro Arg Asp  Gly Gln Ala 
    1205                 1210                 1215             


Tyr Val  Arg Lys Asp Gly Glu  Trp Val Leu Leu Ser  Thr Phe Leu 
    1220                 1225                 1230             


Leu Glu  Val Leu Phe Gln Gly  Pro Ala Gly Trp Ser  His Pro Gln 
    1235                 1240                 1245             


Phe Glu  Lys Gly Gly Gly Ser  Gly Gly Gly Ser Gly  Gly Gly Ser 
    1250                 1255                 1260             


Trp Ser  His Pro Gln Phe Glu  Lys 
    1265                 1270     


<210>  33
<211>  1179
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: VFLIP

<400>  33

Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Val Ile Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Asp Ser Ser Ser Gly Trp Thr Ala 
225                 230                 235                 240 


Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu 
                245                 250                 255     


Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala 
            260                 265                 270         


Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val 
        275                 280                 285             


Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu 
    290                 295                 300                 


Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu 
305                 310                 315                 320 


Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys 
                325                 330                 335     


Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala 
            340                 345                 350         


Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn 
        355                 360                 365             


Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly 
    370                 375                 380                 


Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp 
385                 390                 395                 400 


Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp 
                405                 410                 415     


Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Gln 
            420                 425                 430         


Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile 
        435                 440                 445             


Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu 
    450                 455                 460                 


Gly Phe Asn Cys Tyr Ser Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr 
465                 470                 475                 480 


Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu 
                485                 490                 495     


Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn 
            500                 505                 510         


Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
        515                 520                 525             


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
    530                 535                 540                 


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
545                 550                 555                 560 


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
                565                 570                 575     


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
            580                 585                 590         


Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
        595                 600                 605             


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
    610                 615                 620                 


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
625                 630                 635                 640 


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Gly 
                645                 650                 655     


Gly Ser Gly Gly Ser Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
            660                 665                 670         


Glu Asn Ser Val Ala Cys Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
        675                 680                 685             


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
    690                 695                 700                 


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
705                 710                 715                 720 


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
                725                 730                 735     


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
            740                 745                 750         


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
        755                 760                 765             


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
    770                 775                 780                 


Lys Arg Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
785                 790                 795                 800 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
                805                 810                 815     


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Asn Val Leu 
            820                 825                 830         


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
        835                 840                 845             


Leu Ala Gly Thr Ile Cys Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala 
    850                 855                 860                 


Leu Gln Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
865                 870                 875                 880 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
                885                 890                 895     


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
            900                 905                 910         


Pro Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
        915                 920                 925             


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
    930                 935                 940                 


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Pro Glu Ala 
945                 950                 955                 960 


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
                965                 970                 975     


Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
            980                 985                 990         


Ala Asn Leu Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
        995                 1000                 1005             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1010                 1015                 1020             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1025                 1030                 1035             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1040                 1045                 1050             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1055                 1060                 1065             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1070                 1075                 1080             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1085                 1090                 1095             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1100                 1105                 1110             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1115                 1120                 1125             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1130                 1135                 1140             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1145                 1150                 1155             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1160                 1165                 1170             


Leu Gly  Lys Tyr Glu Gln 
    1175                 


<210>  34
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO1

<400>  34

Gly Gly Ser 
1           


<210>  35
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO3

<400>  35

Gly Pro 
1       


<210>  36
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO4

<400>  36

Gly Pro Gly Pro 
1               


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: USEO5

<400>  37

Gly Gly Ser Gly Gly Ser 
1               5       


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: linker

<400>  38

Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


