                         SEQUENCE LISTING

<110>  EmendoBio Inc.
 
<120>  NOVEL OMNI 56, 58, 65, 68, 71, 75, 78, AND 84 CRISPR NUCLEASES

<130>  91629-A-PCT/GJG/AWG

<150>  63/094,535
<151>  2020-10-21

<150>  63/117,163
<151>  2020-11-23

<150>  63/119,375
<151>  2020-11-30

<160>  234   

<170>  PatentIn version 3.5

<210>  1
<211>  1203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-56

<400>  1

Met Lys Lys Tyr Lys Leu Gly Leu Asp Val Gly Val Ser Ser Val Gly 
1               5                   10                  15      


Val Ala Val Ile Lys Glu Glu Asn Gly Lys Ser Ser Val Glu Lys Leu 
            20                  25                  30          


Ser Val Arg Ile Val Pro Glu Asp Pro Asn Phe His Gly Lys Phe Tyr 
        35                  40                  45              


Ser Gly Asn Thr Ala Ser Lys Asn Leu Asp Arg Thr Ile Lys Arg Gly 
    50                  55                  60                  


Ile Arg Lys Asn Asn Gln Arg Phe Lys Ala Arg Arg Asp Lys Leu Tyr 
65                  70                  75                  80  


Gln Thr Leu Arg Glu Asn Asn Met Phe Pro Thr Asp Asn Leu Phe Asp 
                85                  90                  95      


Leu Pro Ala Thr Glu Leu Tyr Gly Leu Arg Ala Lys Ala Val Ser Lys 
            100                 105                 110         


Lys Val Ser Leu Glu Glu Leu Gly Arg Ile Phe Ile Val Leu Asn Gln 
        115                 120                 125             


Arg Arg Gly Phe Leu Ser Asn Arg Lys Ser Val Ser Glu Glu Glu Asn 
    130                 135                 140                 


Ser Thr Glu Tyr Lys Glu Cys Ile Ala Thr Leu Glu Lys Glu Leu Ala 
145                 150                 155                 160 


Gly Arg Thr Ile Gly Gln Lys Leu Tyr Ser Glu Leu Glu Glu Ser Glu 
                165                 170                 175     


Ser Asp Phe Glu Val Leu Leu Arg Glu Arg Thr Tyr Gln Arg Ser Ser 
            180                 185                 190         


Tyr Ile Glu Glu Phe Asp Arg Ile Trp Asp Glu Gln Lys Lys Tyr Tyr 
        195                 200                 205             


Ser Val Leu Thr Gly Gly Ala Asn Glu Asp Asn Asn Lys Glu Thr Leu 
    210                 215                 220                 


Tyr Asp Leu Ile Arg Asn Arg Ile Ile Tyr Tyr Gln Arg Pro Leu Lys 
225                 230                 235                 240 


Ser Gln Lys Gly Leu Ile Ser Glu Cys Ser Phe Glu Lys Tyr His Lys 
                245                 250                 255     


Ala Thr Ala Lys Ser Ser Pro Tyr Phe Glu Leu Phe Arg Ile Trp Gln 
            260                 265                 270         


Lys Val Asn Asp Leu Ser Trp Lys Thr Pro Gly Gly Glu Thr Phe Lys 
        275                 280                 285             


Pro Thr Leu Gly Gln Lys Gln Asn Leu Lys Glu Ala Leu Trp Asn Gly 
    290                 295                 300                 


Glu Asn Leu Asn Ala Lys His Lys Leu Ser Val Thr Glu Ile Lys Lys 
305                 310                 315                 320 


Leu Leu Gly Tyr Gly Arg Asn Glu Lys Ile Tyr Leu Asn Phe Thr Glu 
                325                 330                 335     


Leu Asp Gly Ser Arg Thr Tyr Thr Val Leu Lys Asn Ala Leu Glu Glu 
            340                 345                 350         


Ala Gly Ile Glu Asn Phe Gln Gln Tyr Leu Phe Phe Asn Leu Asp Ile 
        355                 360                 365             


Ser Asp Glu Lys Gly Gly Leu Phe Glu Leu Trp His Ile Thr Tyr Ser 
    370                 375                 380                 


Leu Pro Thr Glu Lys Glu Val Val Asn Ala Leu Lys Asn Arg Phe Gly 
385                 390                 395                 400 


Phe Ser Glu Asn Gln Ser Glu Ile Ile Ala Lys Lys Val Gly Tyr Pro 
                405                 410                 415     


Ser Asn Tyr Gly Asn Leu Ser Thr Arg Ala Ile Arg Lys Leu Leu Pro 
            420                 425                 430         


Tyr Leu Glu Lys Gly Leu Gly Tyr Ser Glu Ala Cys Asp Ala Val Gly 
        435                 440                 445             


Tyr Asp His Ser Gly Tyr Lys Thr Glu Ile Glu Leu Lys Pro Asn Leu 
    450                 455                 460                 


Lys Gln Leu Lys Lys Asn Glu Leu Arg Asn Pro Val Val Glu Gln Ile 
465                 470                 475                 480 


Leu Asn Gln Val Val Asn Val Val Asn Leu Val Ile Glu Lys Tyr Gly 
                485                 490                 495     


Lys Ile Asp Glu Ile Arg Val Glu Leu Ala Arg Glu Leu Arg Asn Asn 
            500                 505                 510         


Ala Lys Thr Arg Lys Asn Ile Ser Gln Ala Asn Ser Lys Asn Lys Arg 
        515                 520                 525             


Asn Asn Asp Val Ile Arg Lys Lys Leu Ile Glu Glu Tyr Gly Phe Arg 
    530                 535                 540                 


Leu Val Asn Gly Arg Asp Val Lys Arg Tyr Ile Leu Trp Glu Glu Thr 
545                 550                 555                 560 


Ala His Glu Cys Leu Tyr Cys Asn Asn Pro Ile Asn Gly Thr Asp Met 
                565                 570                 575     


Leu Thr Gly Asn Ala Asp Ile Glu His Val Leu Pro Lys Ser Arg Ser 
            580                 585                 590         


Phe Ser Asn Ala Met Asn Asn Tyr Ile Ile Ala His Arg Lys Cys Asn 
        595                 600                 605             


Ser Asn Lys Gly Gln Lys Thr Ala Tyr Asp Phe Met Glu Ser Lys Gly 
    610                 615                 620                 


Glu Glu Val Leu Gly Gln Tyr Ile Glu Lys Val Asn Ala Leu Tyr Asn 
625                 630                 635                 640 


Asp Gly Lys Gly Ser Ile Ser Lys Ser Lys Phe Asp Asn Leu Leu Cys 
                645                 650                 655     


Lys Gly Glu Asp Ile Pro Ser Asp Phe Val Glu Arg Met Lys Lys Asp 
            660                 665                 670         


Ser Gln Tyr Ile Ser Lys Glu Val Val Lys Met Leu Lys Thr Val Cys 
        675                 680                 685             


Pro Asn Val Tyr Thr Thr Thr Gly Gln Val Thr Asp Phe Leu Arg Glu 
    690                 695                 700                 


Glu Trp Lys Leu Lys Asn Leu Leu Gln Glu Leu Thr Phe Asp Lys Tyr 
705                 710                 715                 720 


Lys Ala Ile Gly Gln Val Glu Glu Lys Thr Ile Lys Thr Lys Asn Gly 
                725                 730                 735     


Gln Thr Lys Thr Phe Glu Thr Ile Thr Asp Trp Ser Lys Arg Asp Asp 
            740                 745                 750         


His Arg His His Ala Val Asp Ala Leu Ile Cys Ala Leu Thr Asn Gln 
        755                 760                 765             


Lys Ile Ile Phe Lys Leu Asn Asn Leu Asn Lys Ile Tyr Gln Tyr Glu 
    770                 775                 780                 


Arg Asp Ala Leu Ser Gln Lys Glu Ile Glu Glu Phe Glu Glu Phe Leu 
785                 790                 795                 800 


Glu Gly Lys Phe Ser Leu Lys Glu Phe Ser Thr Gln Gln Glu Asn Ile 
                805                 810                 815     


Ile Glu Cys Ser Ile Pro Asn Ile Arg Arg Glu Val Gln Lys His Leu 
            820                 825                 830         


Glu Glu Ile Phe Ile Ser Phe Lys Lys Glu Asn Ser Lys Val Leu Thr 
        835                 840                 845             


Lys Asn Ile Asn Ala Pro Lys Asn Val Glu Pro Lys Thr Thr Trp Val 
    850                 855                 860                 


Pro Arg Ala Arg Leu His Glu Asp Thr Ile Met Gly Arg Val Lys Arg 
865                 870                 875                 880 


Ile Ala Glu Lys Lys Met Lys Leu Ser Asp Lys Val Ser Met Glu Glu 
                885                 890                 895     


Ile Glu Met Val Val Asn Pro Glu Ile Lys Glu Ile Leu Tyr Gln His 
            900                 905                 910         


Leu Thr Lys Phe Asp Asn Asn Pro Lys Ile Ala Phe Ala Gln Lys Thr 
        915                 920                 925             


Leu Lys Gly Glu Leu Ile Ser Tyr Lys Gly Asn Glu Ile Lys Glu Val 
    930                 935                 940                 


Gly Val Tyr Glu Trp Val Asn Thr Lys Arg Val Asn Val Glu Asn Phe 
945                 950                 955                 960 


Leu Thr Asp Asn Gln Lys Thr Thr Ser Ala Lys Asp Lys Phe Ile Glu 
                965                 970                 975     


Asn Ile Leu Lys Ser Asp Arg Gly Ile Gly Val Leu Leu Asp Arg Arg 
            980                 985                 990         


Leu Lys Glu Phe Asn Gly Asp Tyr  Lys Glu Ala Phe Lys  Asn Leu Ser 
        995                 1000                 1005             


Glu Asn  Pro Ile Ile Thr Lys  Asn Gly Met Ile Val  Lys Asn Val 
    1010                 1015                 1020             


Thr Ile  Tyr Asp Glu Ser Lys  Val Glu Arg Val Arg  Asn Gly Tyr 
    1025                 1030                 1035             


Ala Lys  Thr Gly Gly Asn His  His Ala Leu Ile Tyr  Lys Asp Lys 
    1040                 1045                 1050             


Asn Gly  Lys Tyr Asn Asp Lys  Val Val Ser Phe Trp  Glu Ala Val 
    1055                 1060                 1065             


Glu Ile  Gly Leu Leu Asn Ile  Ala Val His His Asn  Pro Tyr Pro 
    1070                 1075                 1080             


Ile Ile  Asn Arg Asn Asp Asn  Glu Glu Phe Gly Thr  Phe Gln Phe 
    1085                 1090                 1095             


Ser Met  Gln Ile Asn Asp Leu  Phe Val Phe Asp Leu  Lys His Ser 
    1100                 1105                 1110             


Asp Asn  Pro Gln Glu Glu Asn  Glu Ile Asp Phe Phe  Asp Val Lys 
    1115                 1120                 1125             


Asn Arg  Lys Leu Ile Ser Asn  Asn Leu Phe Arg Val  Gln Lys Met 
    1130                 1135                 1140             


Thr Lys  Lys Ser Ser Gly Ala  Phe Glu Val Thr Tyr  Arg His His 
    1145                 1150                 1155             


Leu Glu  Ala Asn Leu Asn Arg  Ser Asp Lys Ile Leu  Lys Gly Tyr 
    1160                 1165                 1170             


Thr Trp  Asp Glu His Gly Ser  Asn Lys His Leu Glu  Arg Leu Thr 
    1175                 1180                 1185             


Lys Ile  Arg Ile Asn His Leu  Gly Glu Ile Ile Lys  Ile Gly Glu 
    1190                 1195                 1200             


<210>  2
<211>  1023
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-58

<400>  2

Met Thr Leu Glu Glu Phe Arg Ser Lys Asp Arg Val Ile Trp Ala Gly 
1               5                   10                  15      


Leu Asp Ile Gly Val Ala Ser Thr Gly Leu Cys Leu Val Asp Val Arg 
            20                  25                  30          


Asn His Glu Ile Val Leu Met Ala Ser His Leu Phe Lys Ser Pro Val 
        35                  40                  45              


Val Asp Lys Lys Lys Ala Thr Ala Ala Pro Glu Ser Leu Ala Ser Val 
    50                  55                  60                  


Arg Arg Gly Ala Arg Ser Val Arg Arg Asn Ile Met Arg Glu Gly Arg 
65                  70                  75                  80  


Arg Lys Lys Ala Ile Arg Ala Ala Leu Ala Asp Phe Asp Leu Ile Pro 
                85                  90                  95      


Ala Asp Thr Asp Gly Glu Trp Phe Ser Ala Arg Arg Asp Glu Arg Thr 
            100                 105                 110         


Val Val Arg Leu Arg Ser Lys Ala Leu Gly Tyr Leu Leu Asn Ser Arg 
        115                 120                 125             


Glu Leu Ala Arg Val Leu Tyr Ser Phe Ala Ser His Arg Gly Tyr Ile 
    130                 135                 140                 


Asp His Gly Lys Ser Asp Lys Glu Asp Asp Ala Gly Lys Val Lys Lys 
145                 150                 155                 160 


Ala Leu Ala Ala Asn His Ala Ala Leu Ala Asp Gly Gly Cys Lys Thr 
                165                 170                 175     


Phe Gly Gln Tyr Leu Ala Gly Gln Pro Arg Ser Arg Asn Arg Ala Gly 
            180                 185                 190         


Asp Tyr Ser Tyr Thr Ala Asp Ile Gly Met Thr Val Asp Glu Val Arg 
        195                 200                 205             


Thr Ile Phe Thr Arg Gln Arg Glu Leu Gly Ser Glu Ile Ala Ser Lys 
    210                 215                 220                 


Ala Leu Glu Glu Arg Tyr Ile Ala Glu Leu Thr Trp Leu Thr Asp Thr 
225                 230                 235                 240 


Ser Lys Arg Asp Arg Ser Thr Tyr Leu Lys Val Gly Phe Cys Thr Tyr 
                245                 250                 255     


Leu Gly Ala Pro Tyr Arg Arg Gly Ala Thr Ser Thr Ile Ser Phe Glu 
            260                 265                 270         


Met Val Arg Ala His Gln Thr Leu Cys Asn Thr Val Ile Leu His Ala 
        275                 280                 285             


Asp Gly Thr Ser Ser Thr Ile Pro Gly Asp Ile Arg Ile Glu Ile Val 
    290                 295                 300                 


Arg Glu Leu Phe Asp Val Lys Arg Ser Val Lys Pro Leu Lys Trp Ser 
305                 310                 315                 320 


Gly Leu Arg Arg Arg Leu Gly Leu Ala Glu Cys Asp Ser Phe Lys Gly 
                325                 330                 335     


Arg Pro Ala Glu Glu Glu Lys Arg Asp Cys Ile Ala Leu Pro Ala Trp 
            340                 345                 350         


Ala Val Leu Cys Ser Gly Leu Tyr Glu Asn His Arg Asp Leu Leu Glu 
        355                 360                 365             


Arg Leu His Asp His Ile Asp Asp Ala Asp Ala Val Cys Ser Ala Leu 
    370                 375                 380                 


Thr Phe Ala Ser Ser Ala Ala Ser Leu Ala Gly Arg Leu Ala Pro Leu 
385                 390                 395                 400 


Ala Leu Thr Asp Asp Glu Val Glu Ala Ile Ile Asp Leu Pro Tyr Ser 
                405                 410                 415     


Ala Arg Leu Phe Ser Gly Tyr Ala Asn Ala Ser Pro Glu Ala Leu Gln 
            420                 425                 430         


Met Leu Arg Gly Thr Phe Glu Asp Pro Arg Val Thr Ser Leu Arg Gln 
        435                 440                 445             


Ala Glu Glu Asp Ser Gly Leu Ala Gln Ala Arg Ala Met Leu Ala Glu 
    450                 455                 460                 


Glu Arg Gly Gly Ser Ala Asp Gly Leu Leu Cys Ala Phe Ser Asp Tyr 
465                 470                 475                 480 


Asp Pro Thr Cys Arg Asn Pro Val Val Leu Arg Ala Thr Ala Gln Val 
                485                 490                 495     


Arg Arg Met Val Asn Ser Val Ile Arg His Tyr Gly Leu Pro Asp Val 
            500                 505                 510         


Ile Arg Val Glu Val Ala Arg Asp Leu Lys Arg Ser Lys His Glu Arg 
        515                 520                 525             


Glu Ile Val Ala Glu Ser Asn Arg Ala Arg Leu Glu Leu Asn Glu Gln 
    530                 535                 540                 


Ala Lys Arg Asp Ile Ile Glu Phe Leu Gly Leu Pro Asp Asp His His 
545                 550                 555                 560 


Val Arg Gly Arg Asp Leu Ala Leu Val Lys Leu Tyr Arg Glu Gln Gly 
                565                 570                 575     


Gly Lys Asp Pro Tyr Thr Gly Ala Gly Ile Asp Phe Arg Arg Met Leu 
            580                 585                 590         


Glu Glu His Gly Tyr Ala Glu Ile Asp His Ile Leu Pro Val Ser Arg 
        595                 600                 605             


Thr Cys Asp Asp Ser Gln Ala Asn Lys Val Leu Cys Leu Thr Lys Ser 
    610                 615                 620                 


Asn Arg Asp Lys Ser Asn Arg Ser Pro Tyr Glu Trp Met Thr Ser Gly 
625                 630                 635                 640 


Glu Ala Ser Ala Pro Asp Trp Gly Glu Phe Cys Gly Arg Met Glu Arg 
                645                 650                 655     


Trp Ala Lys Met Cys Glu Thr Arg Arg Tyr Ala Arg Lys Lys Leu Ala 
            660                 665                 670         


Asn Leu Thr Cys Glu Asn Leu Ala Glu Arg Ala Asp Asn Phe Ile Asp 
        675                 680                 685             


Arg Asn Leu Asn Asp Thr Arg Tyr Met Ser Val Ala Leu Ala Lys Trp 
    690                 695                 700                 


Leu Arg Glu Cys Leu Pro Phe Thr Lys Asp Gly His Glu His Val Phe 
705                 710                 715                 720 


Cys Val Ala Gly Gly Ala Thr Ala Leu Met Arg Ser Val Trp Asn Ile 
                725                 730                 735     


Gly Ile Thr Gly Pro Asp Gly Lys Lys Asn Arg Glu Asp Asp Arg His 
            740                 745                 750         


His Ala Val Asp Ala Ala Val Ile Ala Cys Cys Thr Pro Gly Ile Val 
        755                 760                 765             


Arg Asn Val Ala Leu Val Asn Glu Gly His Ala Arg Ala Asp Val Arg 
    770                 775                 780                 


Gln Arg Leu Phe Ser Asp Ser Leu Pro Tyr Pro Glu Phe Lys Glu Gln 
785                 790                 795                 800 


Val Asp Ala Trp Ile Pro Cys Ile Val Pro Thr Leu Thr Leu Pro Asn 
                805                 810                 815     


Thr Val Thr Gly Ser Val Leu Lys Asp Thr Val Tyr Pro Tyr Leu Gly 
            820                 825                 830         


Arg Asp Glu Ala Gly Lys Asp Leu Tyr Ile Thr Val Lys Arg Asp Lys 
        835                 840                 845             


Asp Gly Arg Ile Val Glu Arg Lys Val Asn Lys Ala Thr Thr Met Trp 
    850                 855                 860                 


Lys Asp Gly Gln Gly Gly Cys Arg Ala Tyr Gly Ser Met Cys Ala Leu 
865                 870                 875                 880 


Glu Ala Val Phe Asp Ala Ser Ala Gly Lys Arg Gly Arg Trp Ser Phe 
                885                 890                 895     


Asp Pro Val Tyr Cys Ile Asp Ile Pro His Arg Asp Ala Glu Arg Arg 
            900                 905                 910         


Thr Met Arg Ala Phe Ser Lys Glu Lys Ala Ile Asp Leu Trp Asp Thr 
        915                 920                 925             


Val Ala Val Pro Glu Ala Ala Pro Arg Met Thr Ile Arg Arg Gly Asp 
    930                 935                 940                 


Val Leu Val Cys Asp Gly Lys Ala Ala Arg Phe His Cys Phe Asp Ile 
945                 950                 955                 960 


Ser Val Asn Ala Ile Arg Leu Phe Ser Gln Arg Gly Gly Lys Gln Leu 
                965                 970                 975     


Gln Ala Thr Gly Pro Leu Ser Ala Glu Ala Phe Pro Pro Pro Ser Lys 
            980                 985                 990         


Trp Gly Glu Gly Val Arg Ile Met  Gln Glu Asp Cys Leu  Gly Leu Cys 
        995                 1000                 1005             


Trp Leu  Ser Phe Leu Ala Gln  Arg Ala Val Asp Ala  Gln Met Glu 
    1010                 1015                 1020             


<210>  3
<211>  1144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-65

<400>  3

Met His Tyr Ile Leu Gly Leu Asp Val Gly Ile Gln Ser Val Gly Trp 
1               5                   10                  15      


Ala Val Ile Arg Tyr Asp Glu Pro Ala Arg Ile Glu Asp Phe Gly Val 
            20                  25                  30          


Arg Ile Phe Asp Thr Thr Glu Asn Gln Lys Ser Lys Asp Asn Thr Asn 
        35                  40                  45              


Gln Glu Arg Arg Ala Phe Arg Ala Ala Arg Arg Val Leu Arg Arg Arg 
    50                  55                  60                  


Ser His Arg Arg Ala Met Val Lys Arg His Leu Gln Arg Ile Gly Leu 
65                  70                  75                  80  


Leu Arg Glu Gly Glu Val Glu Ala Phe Phe Glu Ser Gly Gln Ser Asp 
                85                  90                  95      


Pro Leu Arg Leu Arg Val Lys Gly Leu Thr Glu Gln Leu Thr Pro Ala 
            100                 105                 110         


Glu Leu Ala Ala Cys Leu Ile His Ile Ser Asn His Arg Gly Tyr Gln 
        115                 120                 125             


Ala Phe Tyr Asn Leu Thr Glu Glu Glu Leu Lys Glu Leu Pro Ala Ala 
    130                 135                 140                 


Glu Arg Lys Glu Tyr Gln Gln Glu Arg Ser Gly Ile Glu Leu Val Glu 
145                 150                 155                 160 


Gly Ile Met Glu Gln Gly His Tyr Arg Ser Val Ala Glu Met Leu Leu 
                165                 170                 175     


Thr Asp Asp Thr Phe Ala Pro Asp His Ala Gly Pro Met Arg Val Tyr 
            180                 185                 190         


Arg Ser His Pro Tyr Leu Asp Thr Arg Tyr Pro Ile Ser Arg Asp Leu 
        195                 200                 205             


Leu Arg Lys Glu Ala Asp Ala Ile Leu Thr Asn Gln Ala Arg Phe Tyr 
    210                 215                 220                 


Pro Cys Leu Asn Ala Pro Tyr Gln Thr Thr Trp Arg Lys Glu Ser Lys 
225                 230                 235                 240 


Thr Thr Thr Asn Arg Ala Phe Leu Glu Trp Leu Ile Phe Thr Gln Arg 
                245                 250                 255     


Asp Phe Glu Asp Gly Pro Gly Asp Arg Asp Asp Ala Met Arg Lys Tyr 
            260                 265                 270         


Thr Gly Phe Leu Gln Ala Leu Gly Lys Cys Pro Phe Tyr Arg Glu Glu 
        275                 280                 285             


Asp Arg Gly Pro Arg Met Thr Val Leu Gly Asp Leu Tyr Ala Leu Thr 
    290                 295                 300                 


Asn Ser Leu Ser Gln Tyr Gln Tyr Met Asn Thr Glu Thr Gly Val Phe 
305                 310                 315                 320 


Glu Leu Pro Lys Glu Leu Ala Glu Ala Met Leu Ala Ala Ala Leu Arg 
                325                 330                 335     


Asp Ala Glu Leu Pro Ala Lys Lys Ile Gln Glu Leu Ala Lys Arg Tyr 
            340                 345                 350         


His Ile Lys Val Asp Asn Lys Ala Val Lys Thr Ala Asp Arg Ala Pro 
        355                 360                 365             


Asn Cys Ile Lys Phe Leu Arg Arg Val Arg Pro Ile Leu Glu Lys Tyr 
    370                 375                 380                 


Gly Ile Asn Trp Glu Thr Ala Leu Gly Gly Thr Thr Leu Glu Asp Val 
385                 390                 395                 400 


Leu Ala Asp Asp Thr Met Leu Asn Gln Ile Gly Arg Val Leu Ser Leu 
                405                 410                 415     


Tyr Gln Thr Pro His Arg Arg Gln Glu Glu Leu Val Lys Ile Pro Gly 
            420                 425                 430         


Ile Ser Pro Glu Leu Ala Lys Arg Leu Thr Ala Glu Arg Ile Ser Gly 
        435                 440                 445             


Thr Ala Lys Val Ser Ala His Tyr Met Arg Asp Ala Val Glu Ala Phe 
    450                 455                 460                 


Gln Lys Gly Glu Arg Tyr Gly Glu Phe Gln Trp Arg Arg Met Asn Glu 
465                 470                 475                 480 


Leu Glu Gln Pro Leu Pro Gly Gln Ala Ser Gly Ala His Val Lys Leu 
                485                 490                 495     


Pro Pro Phe Pro Val Asp Ala Glu Phe Ala Lys Asn Ser Val Val Met 
            500                 505                 510         


Arg Ser Leu Asn Glu Thr Arg Lys Ile Ile Asn Ala Ile Val Gly Gln 
        515                 520                 525             


Tyr Gly Ser Pro Trp Ala Val Asn Val Glu Val Ala Ser Asp Leu Gly 
    530                 535                 540                 


Arg Ser Trp Ala Glu Arg Ala Glu Leu Asp Arg Arg Asn Lys Gln Asn 
545                 550                 555                 560 


Glu Ala Gln Thr Glu Lys Asp Lys Gln Gln Ile Cys Gln Ile Met Gly 
                565                 570                 575     


Tyr Asp Ser Pro Asp Gln Val Lys Gly Ser Met Val Glu Arg Phe Gln 
            580                 585                 590         


Leu Ala Gln Gln Gln Asn Trp Gln Cys Leu Tyr Thr Gly Arg Pro Ile 
        595                 600                 605             


Thr Asp Lys Arg Ala Ala Leu Asp Pro Lys Asn Lys Gly Phe Glu Val 
    610                 615                 620                 


Asp His Ile Val Pro Phe Ser Met Ile Leu Asp Asn Thr Leu Gln Asn 
625                 630                 635                 640 


Lys Ala Leu Val Tyr Ala Asp Ala Asn Gln Thr Lys Gly Gln Arg Thr 
                645                 650                 655     


Pro Leu Met Tyr Leu Arg Asp Pro Ala Gln Arg Glu Gln Phe Ile Gly 
            660                 665                 670         


Arg Val Asn Gln Met Ala Lys Asn His Ile Ile Ser Asp Arg Lys Arg 
        675                 680                 685             


Gln Tyr Leu Leu Leu Ala Asp Leu Tyr His Thr Asp Leu Leu Asp Glu 
    690                 695                 700                 


Trp Lys Ser Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ala Lys Tyr Leu 
705                 710                 715                 720 


Arg Gly Tyr Leu Glu Arg Glu Leu Ala Pro Ala Pro Glu His Arg Thr 
                725                 730                 735     


Pro Phe Val Phe Pro Val Lys Gly Gly Leu Thr Ser Arg Phe Arg Arg 
            740                 745                 750         


Thr Trp Leu Asn Arg Ser Thr Trp Gly Gly Asp Glu Lys Ser Glu Leu 
        755                 760                 765             


Arg Glu Ser Thr Thr Leu His His Ala Val Asp Ala Val Val Ile Ala 
    770                 775                 780                 


Asn Ile Ser Pro Ala Thr Ala Gln Ile Ala Glu Asp Asn Leu Arg Leu 
785                 790                 795                 800 


Asn Arg Ile Leu Lys Asn Ser Arg Gly Ile Glu Arg Pro Glu Tyr Arg 
                805                 810                 815     


Ala Gln Leu Glu Arg Ser Leu Gln Thr Leu Glu Gln Phe Tyr His Val 
            820                 825                 830         


Pro Arg Thr Arg Gly Glu Ala Cys Leu Lys Arg Gln Asn Arg Ile Thr 
        835                 840                 845             


Ala Leu Ile Ala Asn Leu Asn Ile Glu Val Asp Ile Arg Phe Gly Val 
    850                 855                 860                 


Pro Gly Gln Thr Thr Asp Pro Asp Ser Tyr Arg Ser Leu Val Thr Asn 
865                 870                 875                 880 


Phe Tyr Ala Asp Asp Pro Asp Phe Ala Ala Arg Leu Thr Gln Pro Leu 
                885                 890                 895     


Thr Ser Arg Lys Pro Glu Arg Lys Leu Gln Gly Thr Leu Thr Thr Ala 
            900                 905                 910         


Asn Ala Leu Gly Thr Lys Glu Ile Asp Gly Val Leu Tyr Glu Ala Lys 
        915                 920                 925             


Arg Thr Asp Val Met Lys Leu Thr Gln Lys Asn Leu Ser Gln Leu Cys 
    930                 935                 940                 


Thr Asn Asp Gly Asp Leu Arg Asp Ser Leu Ala Glu Leu Leu Ala Asp 
945                 950                 955                 960 


Ala Gly Thr Arg Thr Leu Ala Asp Val Leu Ser Glu Gln Gly Lys Thr 
                965                 970                 975     


Glu Phe Arg Thr Gln Lys Gly Gln Leu Ile Arg Lys Val Thr Leu Lys 
            980                 985                 990         


Gly Ser Val Val Asp Gln Tyr Lys  Ile Lys Gln Ile Ala  Pro Asn Asn 
        995                 1000                 1005             


Tyr Ser  Val Leu Asp Thr Thr  Ser Tyr Tyr Cys Thr  Glu Val Tyr 
    1010                 1015                 1020             


Arg Asp  Pro Ala Gly Lys Thr  Arg Val Arg Ala Ile  Ala Arg Ala 
    1025                 1030                 1035             


Ser Leu  Val Cys Lys Gly Lys  Lys Leu Trp Leu Thr  Cys Pro Asn 
    1040                 1045                 1050             


Pro Ala  Asp Tyr Ala Glu His  Ile Met Tyr Leu Phe  Lys Asn Asp 
    1055                 1060                 1065             


Tyr Ile  Arg Val Glu Thr Pro  Asn Gly Leu Gln Phe  Glu Gly Phe 
    1070                 1075                 1080             


Tyr Gln  Ser Pro Ala Gly Ile  Lys Gln Ala Lys Phe  Asn Gly Ile 
    1085                 1090                 1095             


Lys Asn  Asn Asp Ala Lys Ser  Cys Pro Phe His Ile  Ser Gly Gly 
    1100                 1105                 1110             


Ala Val  Val Lys Lys Tyr Asp  Ile Ser Ile Leu Gly  Arg Lys Gly 
    1115                 1120                 1125             


Gly Glu  Ile Pro Cys Gly Glu  Pro Leu Ser Leu Leu  Leu Glu Lys 
    1130                 1135                 1140             


Lys 
    


<210>  4
<211>  1154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-68

<400>  4

Met Val Val Asn Met Glu Gly Val Ser Ile Met His Tyr Val Leu Gly 
1               5                   10                  15      


Leu Asp Ile Gly Ile Gln Ser Val Gly Trp Ala Val Ile Arg Tyr Asp 
            20                  25                  30          


Glu Pro Ala Arg Ile Glu Asp Phe Gly Val Arg Ile Phe Asp Thr Thr 
        35                  40                  45              


Glu Asn Arg Lys Ser Lys Asp Asn Ala Asn Gln Glu Arg Arg Ala Phe 
    50                  55                  60                  


Arg Ala Ala Arg Arg Val Val Arg Arg Arg Ser His Arg Arg Glu Met 
65                  70                  75                  80  


Leu Lys Lys His Leu Gln Arg Ile Gly Leu Leu Arg Glu Gly Glu Val 
                85                  90                  95      


Glu Ala Phe Phe Glu Ser Gly Lys Ser Asp Pro Leu Arg Leu Arg Val 
            100                 105                 110         


Lys Gly Leu Thr Glu Gln Leu Thr Pro Val Glu Leu Ala Ala Cys Leu 
        115                 120                 125             


Ile His Ile Ser Asn His Arg Gly Tyr Gln Ala Phe Tyr Asn Leu Thr 
    130                 135                 140                 


Glu Glu Glu Leu Asn Glu Leu Pro Ala Ser Glu Lys Lys Glu Tyr Gln 
145                 150                 155                 160 


Gln Glu Arg Ser Gly Ile Glu Gln Val Thr Gly Leu Met Glu Gln Gly 
                165                 170                 175     


Asn Tyr Arg Ser Val Ala Glu Met Leu Leu Thr Asp Ala Ala Phe Ala 
            180                 185                 190         


Ser Glu Asp Gly Gly Pro Met Arg Thr Tyr Arg Ser His Pro Tyr Lys 
        195                 200                 205             


Asp Thr Arg Tyr Pro Ile Ser Arg Asp Leu Leu Arg Lys Glu Ala Asp 
    210                 215                 220                 


Ala Ile Leu Met Asn Gln Ala Gln Phe Tyr Pro Cys Leu Asn Glu Ala 
225                 230                 235                 240 


Tyr Gln Val Thr Trp Arg Lys Glu Ser Arg Thr Pro Ser Asn Arg Glu 
                245                 250                 255     


Phe Leu Glu Trp Leu Met Phe Glu Gln Arg Asp Phe Glu Asp Gly Pro 
            260                 265                 270         


Gly Asp Arg Asp Asp Ala Met Arg Lys Tyr Thr Gly Phe Leu Gln Ala 
        275                 280                 285             


Leu Gly Lys Cys Ser Phe Tyr Arg Gln Glu Asp Arg Gly Pro Arg Met 
    290                 295                 300                 


Ser Val Leu Gly Asp Leu Tyr Ala Leu Thr Asn Ser Leu Ser Gln Tyr 
305                 310                 315                 320 


Gln Tyr Ile Asp Glu Lys Thr Ser Ala Phe Gly Met Pro Lys Thr Leu 
                325                 330                 335     


Ala Asn Asp Leu Leu Glu Ala Ala Leu His Asp Ala Glu Leu Pro Ala 
            340                 345                 350         


Lys Arg Ile Gln Glu Leu Ala Arg Lys His Ser Val Lys Ile Asp Asn 
        355                 360                 365             


Lys Ala Val Lys Thr Ala Asp Arg Ala Pro Asn Cys Ile Lys Phe Met 
    370                 375                 380                 


Arg Arg Ile Arg Pro Ile Leu Glu Lys Tyr Gly Ile Asp Trp Glu Gln 
385                 390                 395                 400 


Ala Leu Gly Gly Ala Thr Leu Glu Glu Ala Leu Asp Asp Asn Thr Met 
                405                 410                 415     


Leu Asn Arg Ile Gly Arg Val Leu Ser Leu Tyr Gln Thr Leu His Arg 
            420                 425                 430         


Arg Lys Glu Glu Leu Val Lys Ile Pro Gly Ile Ser Pro Glu Leu Ala 
        435                 440                 445             


Ser Arg Leu Thr Ala Glu Arg Ile Ser Gly Thr Ala Lys Val Ser Ala 
    450                 455                 460                 


His Tyr Met Arg Asp Ala Val Glu Ala Phe Gln Leu Gly Glu Arg Tyr 
465                 470                 475                 480 


Gly Glu Phe Gln Trp Arg Arg Met Asn Glu Gln Glu Gln Pro Leu Pro 
                485                 490                 495     


Gly Gln Ala Ser Gly Ala Asn Phe Lys Leu Pro Ala Phe Pro Ala Ser 
            500                 505                 510         


Ala Glu Phe Ala Lys Asn Ser Val Val Met Arg Ser Leu Asn Glu Thr 
        515                 520                 525             


Arg Lys Val Ile Asn Ala Val Ile Glu Arg Tyr Gly Ser Pro Trp Ala 
    530                 535                 540                 


Val Asn Val Glu Val Ala Ser Glu Leu Gly Arg Ser Trp Ala Glu Arg 
545                 550                 555                 560 


Asp Glu Leu Asp Arg Arg Asn Lys Gln Asn Leu Ala Gln Thr Glu Lys 
                565                 570                 575     


Asp Lys Lys Gln Ile Cys Glu Ile Met Gly Tyr His Ser Pro Asp Gln 
            580                 585                 590         


Val Asn Gly Ser Met Leu Glu Arg Phe Arg Leu Ala Gln Gln Gln Asn 
        595                 600                 605             


Trp Gln Cys Leu Tyr Thr Gly Lys Pro Ile Thr Asp Lys Gln Ala Ala 
    610                 615                 620                 


Leu Asp Ser Lys Asn Arg Ser Tyr Glu Val Asp His Ile Val Pro Phe 
625                 630                 635                 640 


Ser Leu Ile Leu Asp Asn Thr Leu Gln Asn Lys Ala Leu Val Cys Ala 
                645                 650                 655     


Asp Ala Asn Gln Thr Lys Gly Gln Arg Thr Pro Leu Met Tyr Leu Arg 
            660                 665                 670         


Asp Pro Gln Gln Arg Glu Leu Phe Ile Gly Arg Val Asn Gln Met Ala 
        675                 680                 685             


Lys Asn His Val Ile Ser Asp Arg Lys Arg Gln Tyr Leu Leu Leu Glu 
    690                 695                 700                 


His Leu Gly Asn Ser Glu Leu Leu Asp Glu Trp Lys Thr Arg Asn Leu 
705                 710                 715                 720 


Asn Asp Thr Arg Tyr Ile Ala Lys Tyr Leu Arg Gly Tyr Leu Glu Arg 
                725                 730                 735     


Glu Leu Ala Pro Ala Ala Glu His Arg Thr Pro Phe Val Phe Pro Val 
            740                 745                 750         


Lys Gly Gly Leu Thr Ser Arg Phe Arg Arg Val Trp Leu Asp Arg Glu 
        755                 760                 765             


Thr Trp Gly Gly Asp Glu Lys Gly Gln Leu Arg Glu Thr Thr Thr Leu 
    770                 775                 780                 


His His Ala Val Asp Ala Val Val Ile Ala Asn Ile Thr Pro Ala Thr 
785                 790                 795                 800 


Ala Leu Ile Ala Glu Asp Asn Leu Arg Leu Asn Arg Ile Leu Lys Ser 
                805                 810                 815     


Ser His Gly Val Glu Thr Ala Glu Tyr Cys Ala Gln Leu Glu Arg Ser 
            820                 825                 830         


Leu Gln Thr Leu Glu Gln Tyr Tyr His Ile Pro Arg Ala Lys Ala Gln 
        835                 840                 845             


Ala Tyr Leu Lys Arg Lys Asn Arg Ile Thr Ala Leu Ile Pro Thr Leu 
    850                 855                 860                 


Asn Ile Glu Val Asn Ile Arg Phe Gly Ser Pro Gly Glu Glu Ile Asp 
865                 870                 875                 880 


Pro Asp Thr Tyr Arg Ala Cys Val Leu Tyr His Tyr His Asp Asp Pro 
                885                 890                 895     


Ala Phe Ala Ala Gly Leu Thr Pro Pro Cys Thr Ser Arg Lys Pro Glu 
            900                 905                 910         


Arg Lys Val Gln Gly Gly Leu Thr Thr Ala Asn Ala Leu Gly Thr Met 
        915                 920                 925             


Glu Ile Asp Gly Val Leu Tyr Glu Ala Lys Arg Val Asp Val Met Lys 
    930                 935                 940                 


Leu Ser Trp Lys Asn Leu Ser Gln Leu Cys Thr Asn Asp Gly Asp Leu 
945                 950                 955                 960 


Arg Asp Ser Leu Ile Glu Leu Leu Ala Glu Thr Gly Asp Lys Lys Leu 
                965                 970                 975     


Glu Asp Ile Leu Ser Ala Gln Asn Lys Thr Glu Phe Arg Thr Arg Lys 
            980                 985                 990         


Gly Arg Leu Ile Arg Lys Val Thr  Leu Lys Gly Asn Val  Val Asp Gln 
        995                 1000                 1005             


Tyr Arg  Val Lys Gln Ile Ala  Pro Asn Asn Tyr Ser  Val Leu Asn 
    1010                 1015                 1020             


Thr Thr  Ser Tyr Tyr Cys Thr  Glu Val Tyr Arg Asp  Thr Ala Gly 
    1025                 1030                 1035             


Lys Thr  Lys Val Arg Ala Ile  Ala Arg Ala Asp Leu  Val Arg Arg 
    1040                 1045                 1050             


Asp Lys  Lys Leu Trp Leu Thr  Cys Pro Ala Pro Ala  Asp Tyr Ala 
    1055                 1060                 1065             


Glu His  Ile Met Tyr Leu Phe  Lys Asn Asp Tyr Ile  Gln Val Gln 
    1070                 1075                 1080             


Thr His  Asn Gly Val Leu Phe  Glu Gly Phe Tyr Gln  Ser Pro Ala 
    1085                 1090                 1095             


Gly Ile  Lys Gln Ala Lys Phe  Asn Gly Ile Glu Lys  Asn Ala Ser 
    1100                 1105                 1110             


Gly Ser  Arg Pro Phe Arg Ile  Ser Gly Thr Ala Thr  Val Thr Lys 
    1115                 1120                 1125             


Tyr Asp  Ile Ser Ile Leu Gly  Lys Lys Gly Gly Glu  Ile Pro Cys 
    1130                 1135                 1140             


Gly Ala  Pro Leu Ser Leu Leu  Pro Glu Arg Lys 
    1145                 1150                 


<210>  5
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-71

<400>  5

Met Thr Trp Arg Leu Gly Leu Asp Val Gly Thr Asn Ser Val Gly Trp 
1               5                   10                  15      


Ala Ala Leu Gly Leu Gly Pro Thr Gly Pro Glu Thr Leu Ile Gly Thr 
            20                  25                  30          


Gly Val Arg Ile Phe Ser Asp Gly Arg Asn Pro Lys Asp Gly Ser Ser 
        35                  40                  45              


Leu Ala Thr Lys Arg Arg Glu Pro Arg Ser Ala Arg Arg Asn Arg Asp 
    50                  55                  60                  


Arg Tyr Leu Lys Arg Arg Ser Glu Phe Met Glu Arg Leu Val Ala Phe 
65                  70                  75                  80  


Gly Leu Met Pro Lys Asp Glu Ser Lys Arg Lys Glu Leu Glu His Leu 
                85                  90                  95      


Asp Pro Trp Ile Leu Arg Cys Arg Ala Leu Asp Glu Pro Leu Thr Ala 
            100                 105                 110         


His Glu Ile Gly Arg Ala Leu Phe His Leu Gln Gln Arg Arg Gly Phe 
        115                 120                 125             


Lys Ser Asn Arg Lys Ala Asp Arg Gly Asp Ser Asp Lys Gly Ala Ile 
    130                 135                 140                 


Ala Glu Ala Arg Glu Arg Thr Leu Asp Arg Leu Ala Asn Glu Gly Ala 
145                 150                 155                 160 


Arg Thr Leu Gly Glu Leu Phe Gly Arg Arg Arg Met Asp Ala Ala Gln 
                165                 170                 175     


Asn Asn Ala Val Thr Ser Lys Gly Ala Arg Gln Pro Gln Pro Ala Ala 
            180                 185                 190         


Arg Val Ser Pro Tyr Gln Asp Gly Ala Lys Leu Ala Tyr Asp Tyr Tyr 
        195                 200                 205             


Pro Thr Arg Glu Leu Ile Gln Gln Glu Phe Asp Leu Ile Trp Glu Ser 
    210                 215                 220                 


Gln Val Ser Phe Gln Gly Lys Asp Thr Leu Thr Asp Asp Ala Arg Asn 
225                 230                 235                 240 


Ala Leu Ala Asp Thr Leu Leu Tyr Gln Arg Lys Leu Lys Pro Gln Pro 
                245                 250                 255     


Val Gly Lys Cys Ser Leu Asp Pro Thr Gln Thr Arg Ala Glu Arg Ala 
            260                 265                 270         


Leu Pro Ser Ile Gln Arg Leu Arg Ile Tyr Gln Asp Ala Asn His Leu 
        275                 280                 285             


His Val Leu Val Thr Gly Glu Pro Ser Arg Ser Leu Thr Leu Glu Glu 
    290                 295                 300                 


Arg Asp Ile Val Val Asp Arg Leu Leu Gly Ser Ala Arg Val Ser Phe 
305                 310                 315                 320 


Ser Gly Leu Arg Lys Ala Leu Lys Leu Pro Ala Asp Ser Arg Phe Asn 
                325                 330                 335     


Leu Glu Ser Glu Lys Arg Ser Phe Leu Leu Gly Asp Glu Thr Ala Ala 
            340                 345                 350         


Glu Leu Ala Lys Glu Lys Arg Trp Gly Lys Glu Trp Arg Lys Met Leu 
        355                 360                 365             


Phe Ala Asp Gln Glu Arg Ile Val Arg Gln Leu Leu Asp Val Glu Glu 
    370                 375                 380                 


Glu Glu Glu Leu Arg Arg Trp Leu Thr Asp Glu Phe Gly Leu Gly Ala 
385                 390                 395                 400 


Thr Glu Ala Asn Ala Val Ser Asp Ala Ser Leu Pro Glu Gly His Ala 
                405                 410                 415     


Ala Ile Cys Ser Asp Ala Ala Gly Arg Leu Leu Thr Ala Leu Gln Gly 
            420                 425                 430         


Ala Val Ile Thr Tyr Asp Lys Ala Val Ile Glu Ala Gly Phe Leu Ser 
        435                 440                 445             


His Ser Arg Leu Asp His His Gly Glu Ile Leu Asp Arg Leu Pro Tyr 
    450                 455                 460                 


Tyr Gly Lys Val Leu Gln Arg His Val Ala Phe Gly Ser Gly Glu Pro 
465                 470                 475                 480 


Ser Asp Lys Ala Glu Lys Arg Tyr Gly Lys Val Ala Asn Pro Thr Val 
                485                 490                 495     


His Val Ala Leu Asn Gln Ile Arg His Val Val Asn Asp Leu Val Arg 
            500                 505                 510         


Arg Ile Gly Ser Pro Glu Glu Ile Val Ile Glu Leu Ala Arg Asp Leu 
        515                 520                 525             


Pro Leu Ser Ala Gln Gly Lys Arg Asp Leu Glu Lys Arg Gln Arg Glu 
    530                 535                 540                 


Asn Gln Asn Ala Asn Glu Lys Arg Arg Glu Asp Leu Arg Lys Leu Gly 
545                 550                 555                 560 


Arg Ser Asp Thr Tyr Glu Asn Arg Met Arg Leu Arg Leu Trp Glu Glu 
                565                 570                 575     


Leu Asn Pro Glu Asn Val Leu Asp Arg Lys Cys Pro Phe Thr Gly Glu 
            580                 585                 590         


Gln Ile Gly Ile Glu Arg Leu Phe Ser Asp Glu Val Glu Ile Glu His 
        595                 600                 605             


Ile Leu Pro Lys Ser Arg Thr Leu Asp Asp Ser Pro Ala Asn Lys Thr 
    610                 615                 620                 


Leu Cys Met Arg Ser Ala Asn Arg Glu Lys Arg Glu Arg Ser Pro Tyr 
625                 630                 635                 640 


Glu Ala Phe Gly Ser Ser Pro Gly Ser Tyr Ser Trp Gly His Ile Val 
                645                 650                 655     


Ala Arg Ala Ala Asn Met Pro Ser Asn Lys Ser Trp Arg Phe Ala Pro 
            660                 665                 670         


Asp Ala Met Asp Arg Phe Glu Ser Glu Glu Arg Asp Phe Leu Asp Arg 
        675                 680                 685             


Gln Leu Ser Ser Thr Gln Tyr Ile Ala Arg Leu Thr Ala Asn Tyr Leu 
    690                 695                 700                 


Val Trp Leu Val Gly Asp Pro Gly Lys Val His Val Thr Pro Gly Arg 
705                 710                 715                 720 


Leu Thr Ser Asp Leu Arg His His Trp Gly Leu Asn Ser Val Leu Arg 
                725                 730                 735     


Gly His Asn Glu Ala Glu Pro Glu Ala Ile Gly Gln Lys Lys Asn Arg 
            740                 745                 750         


Asn Asp His Arg His His Ala Ile Asp Ala Ile Val Val Ala Leu Thr 
        755                 760                 765             


Asp Arg Gly Leu Leu Lys Lys Ile Ala Thr Gln Ala Ala Arg Asn Gln 
    770                 775                 780                 


Ser Asn Ser Ser Gly Gln Leu Ile Asp Thr Ile Asp Thr Pro Trp Ala 
785                 790                 795                 800 


Ser Phe Arg Asp Asp Val Ala Ala Cys Leu Ser Ser Ile Ile Val Ser 
                805                 810                 815     


His Lys Ala Asp His Gly Val Gln Gly Ala Leu His Asn Asp Thr Ala 
            820                 825                 830         


Tyr Gly Leu Ala Ser Asp Ala Asp Lys Thr Gly Lys Arg Asp Val Val 
        835                 840                 845             


His Arg Val Pro Val Ala Ser Leu Asp Thr Leu Lys Lys Ile Glu Gln 
    850                 855                 860                 


Val Arg Asp Pro Leu Ile Arg Asp Ala Phe Met Asp Ala Ala Ala Gly 
865                 870                 875                 880 


Leu Thr Gly Lys Asp Val Val Thr Ala Val Val Thr Ala Gly Glu Ala 
                885                 890                 895     


Met Thr Pro Pro Val Arg Lys Val Arg Val Leu Glu Arg Met Asn Val 
            900                 905                 910         


Ile Pro Ile Asn Asp Lys Asp Gly Gln Thr Tyr Lys Ala Tyr Lys Gly 
        915                 920                 925             


Asp Gly Asn Tyr Cys Tyr Asp Ile Tyr Ala Asn Glu Lys Gly Gly Trp 
    930                 935                 940                 


Thr Gly Glu Val Val Ser Arg Phe Asp Ala Asn Gln Pro Ser Phe Glu 
945                 950                 955                 960 


Ala Asn Gly Ser Ile Ser Arg Ser Gly Thr Pro Leu Ile Met Arg Ile 
                965                 970                 975     


Arg Gly Gly Asp Thr Leu Leu Ile Asp Gln Gly Gln Gly Glu Arg Phe 
            980                 985                 990         


Met Arg Val Val Lys Phe Ser Ser  Gly Met Ile Cys Leu  Ala Glu His 
        995                 1000                 1005             


Phe Glu  Ala Gly Ser Leu Lys  Ala Arg Asp Thr Asp  Gln His Asp 
    1010                 1015                 1020             


Asp Phe  Lys Tyr Leu Ile Val  Ala Pro Ser Arg Leu  Gln Asn Trp 
    1025                 1030                 1035             


Gly Ala  Gln Ile Val His Val  Ser Pro Ser Gly His  Val Phe Arg 
    1040                 1045                 1050             


<210>  6
<211>  1154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-75

<400>  6

Met Thr Lys Tyr Ser Val Gly Leu Asp Ile Gly Ile Ala Ser Cys Gly 
1               5                   10                  15      


Trp Ser Ile Ile Asp Ile Glu Lys Lys Glu Ile Ile Asp Leu Gly Ser 
            20                  25                  30          


Arg Ile Phe Pro Ser Gly Asn Ala Ala Gly Asn Gln Asp Arg Arg Ser 
        35                  40                  45              


Phe Arg Gly Thr Arg Arg Leu Ile Arg Arg Arg Lys Asn Arg Leu Ser 
    50                  55                  60                  


Asp Leu Thr Lys Phe Leu Ala Glu Asn Gly Phe Ala Val Ser Asn Asp 
65                  70                  75                  80  


Lys Asn Gln Asn Pro Tyr Ala Leu Arg Ser Lys Gly Leu Ala Glu Gln 
                85                  90                  95      


Leu Ser Lys Glu Glu Leu Ala Thr Ala Leu Tyr His Ile Val Asn Arg 
            100                 105                 110         


Arg Gly Ile Ser Tyr Asp Leu Gly Asp Leu Glu Asp Asp Gly Thr Ser 
        115                 120                 125             


Gly Val Ser Asp Tyr Lys Ser Ser Ile Asn Ile Asn Arg Gln Leu Leu 
    130                 135                 140                 


Arg Glu Lys Thr Ile Gly Gln Ile Gln Leu Glu Arg Leu Asn Glu Phe 
145                 150                 155                 160 


Gly Gln Val Arg Gly Gln Val Lys Ala Asp Asp Glu Thr Thr Leu Leu 
                165                 170                 175     


Asn Val Phe Pro Ser Ala Ala Tyr Ala Asp Glu Ala Lys Gln Ile Leu 
            180                 185                 190         


Glu Lys Gln Ala Glu Tyr Tyr Pro Glu Ile Thr Asp Glu Phe Ile Ala 
        195                 200                 205             


Lys Ile Asn Glu Leu Ile Thr Arg Lys Arg Glu Tyr Phe Val Gly Pro 
    210                 215                 220                 


Gly Asn Glu Lys Ser Arg Thr Asp Tyr Gly Ile Tyr Lys Thr Asp Gly 
225                 230                 235                 240 


Arg Thr Leu Asp Asn Leu Phe Asp Glu Leu Ile Gly Thr Asp Lys Ile 
                245                 250                 255     


Asn Gly Glu Lys Arg Ala Ser Ala Ser Ser Leu Thr Ala Gln Ile Tyr 
            260                 265                 270         


Asn Leu Leu Asn Asp Leu Asn Asn Leu Thr Val Pro Asn Thr Glu Asp 
        275                 280                 285             


Gly Lys Leu Thr Thr Glu Thr Lys Lys Glu Ile Leu Ser Ala Ala Lys 
    290                 295                 300                 


Arg Ala Glu Gly Ile Phe Gly Lys Val Gln Ile Cys Lys Leu Ile Gly 
305                 310                 315                 320 


Val Lys Phe Asp Glu Leu Lys Thr Lys Lys Gly Gly Glu Ile Glu Phe 
                325                 330                 335     


Lys His Thr Leu Phe Ala Tyr Arg Lys Phe Arg Lys Ala Leu Ala Glu 
            340                 345                 350         


Ser Asn Ile Glu Ala Asn Asp Leu Ser Thr Glu Phe Phe Asp Lys Ile 
        355                 360                 365             


Ala Asp Ile Leu Thr Leu Asn Thr Glu Lys Ala Glu Ile Arg Lys Gln 
    370                 375                 380                 


Leu Asp Lys Ala Asp Phe Ala Ile Ser Asp Glu Val Lys Glu Leu Ile 
385                 390                 395                 400 


Val Lys Glu Asn Lys Asn Leu Leu Val Asp Gly Arg Ala Thr Trp His 
                405                 410                 415     


Ser Phe Ser Tyr Lys Thr Leu Asn Leu Leu Ile Pro Glu Leu Leu Asn 
            420                 425                 430         


Thr Ser Asp Glu Gln Met Thr Ile Leu Thr Gly Leu Gly Leu Met Lys 
        435                 440                 445             


Pro Asp Asn Glu Lys Tyr Gln Gly Leu Lys Asn Ile Pro Ala Ala Gln 
    450                 455                 460                 


Ile Thr Glu Glu Ile Tyr Asn Pro Val Val Ala Lys Ser Thr Arg Glu 
465                 470                 475                 480 


Ala Ile Asn Val Phe Asn Ala Ile Ala Lys Arg Val Gly Ala Glu Asn 
                485                 490                 495     


Ile Ala His Val Val Ile Glu Leu Pro Arg Glu Asp Asn Glu Asp Asp 
            500                 505                 510         


Val Lys Lys Gln Lys Ile Lys Phe Gln Lys Ala Gln Glu Ala Glu Lys 
        515                 520                 525             


Asn Ala Ala Asp Glu Leu Val Lys Gln Gln Met Thr Ile Pro Asp Ser 
    530                 535                 540                 


Ser Leu Leu Ala Gln Tyr Arg Lys Phe Lys Gly Leu Ser Gln Lys Val 
545                 550                 555                 560 


Arg Tyr Trp Tyr Gln Gln Glu Thr Phe Cys Pro Tyr Cys Gly Glu Lys 
                565                 570                 575     


Ile Lys Val Ile Gln Leu Ile Asn Asn Asn Glu Ser Phe Glu Ile Asp 
            580                 585                 590         


His Ile Ile Pro Ile Ser Val Ser Phe Asp Asp Ser Gln Asn Asn Lys 
        595                 600                 605             


Val Leu Val His Ser Gln Cys Asn Gln Ala Lys Glu Lys Gln Thr Pro 
    610                 615                 620                 


Leu Gly Trp Ile Asn Asn Gly Gly Gly Phe Gly Gln Thr Lys Ala Glu 
625                 630                 635                 640 


Tyr Ile Ala Arg Val Lys Ala Asn Lys Asn Phe Asn Lys Asn Lys Val 
                645                 650                 655     


Asp Asn Leu Leu Asn Asp Ala Asp Leu Asn Asp Ile Ile Thr Arg Arg 
            660                 665                 670         


Ser Phe Ile Gln Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ser Arg Val 
        675                 680                 685             


Val Leu Asp Glu Phe Tyr Ser Phe Phe Lys Ser Asn His Leu Pro Thr 
    690                 695                 700                 


Lys Val Lys Val Val Arg Gly Lys Trp Thr Ser Gln Met Arg Lys Lys 
705                 710                 715                 720 


Trp Asn Ser Ala Gly Gly Leu Ala Lys Thr Arg Asp Thr His His His 
                725                 730                 735     


His Ala Ile Asp Ala Ser Ile Ile Ala Ser Phe Pro Leu Leu Lys Ala 
            740                 745                 750         


Phe Asp Lys Ala Val Lys Leu Ile Asp Ile Asp Lys Glu Thr Gly Glu 
        755                 760                 765             


Ile Leu Gln Asp Lys Ala Ala Val Lys Lys Ala Arg Glu Ala Glu Leu 
    770                 775                 780                 


Leu Ala Gln Trp Ala Ile Pro Asn Glu Lys Glu Phe Glu Lys Leu Asp 
785                 790                 795                 800 


Ser Glu Ile Phe Asp Phe Pro Leu Phe Lys Gln Val Glu Leu Ala Asn 
                805                 810                 815     


Asp Ile Asp Asp Pro Glu Asn Pro Val Lys Phe Ser His Lys Val Asp 
            820                 825                 830         


Lys Lys Ala Asn Arg Ala Val Ala Asn Gln Thr Ile Tyr Gly Thr Arg 
        835                 840                 845             


Met Lys Glu Thr Glu Val Val Lys Arg Gly Lys Thr Glu Ile Val Gln 
    850                 855                 860                 


Asp Glu Tyr Ile Phe Gly Thr Ile Lys Asn Ile Tyr Asn Val Asp Asp 
865                 870                 875                 880 


Phe Ala Lys Phe Lys Lys Leu Tyr Asp Glu Ala Leu Lys Lys Glu Asp 
                885                 890                 895     


Val Lys Phe Leu Met Gln Glu Lys Asp Pro Lys Thr Trp Glu Lys Leu 
            900                 905                 910         


Leu Lys Ile Leu Lys Asn Thr Pro Asp Phe Glu Glu Lys Thr Gln Thr 
        915                 920                 925             


Asp Gly Lys Val Lys Val Ile Pro Val Ser Pro Phe Glu Leu Tyr Arg 
    930                 935                 940                 


Arg Glu Asn Gly Phe Ile Thr Lys Tyr Ala Lys His Asn Asn Gly Pro 
945                 950                 955                 960 


Lys Val Val Ser Leu Lys Tyr Tyr Asp Ser Lys Ile Gly Ser His Ile 
                965                 970                 975     


Asp Ile Thr Pro Glu Asn Ala Arg Asn Lys Val Val Leu Gln Ser Leu 
            980                 985                 990         


Lys Pro Trp Arg Thr Asp Val Tyr  Tyr Asn Pro Asp Thr  Gln Gln Tyr 
        995                 1000                 1005             


Glu Leu  Leu Gly Leu Lys Tyr  Ala Asp Leu Lys Phe  Thr Lys Gly 
    1010                 1015                 1020             


Val Tyr  Gly Ile Thr Glu Glu  Ala Tyr Glu Lys Leu  Lys His Gly 
    1025                 1030                 1035             


Ile Glu  Ala Asp Gly Thr Ile  Leu Trp Lys Pro Ile  Gly Arg Asn 
    1040                 1045                 1050             


Ser Glu  Phe Arg Phe Ser Leu  Tyr Arg Asn Asp Arg  Val Lys Ile 
    1055                 1060                 1065             


Val Asp  Asp Lys Gly Glu Glu  Ile Glu Leu Leu Phe  Gly Ser Arg 
    1070                 1075                 1080             


Ala Gly  Asn Asn Glu Gly Tyr  Val Glu Met Lys Pro  Ile His Lys 
    1085                 1090                 1095             


Ala Arg  Phe Glu Gly Ala Glu  Glu Ile Ala Phe Tyr  Gly Lys Thr 
    1100                 1105                 1110             


Ser Ser  Gly Arg Phe Leu Lys  Pro Leu Ala Lys Lys  Gly Tyr Lys 
    1115                 1120                 1125             


Leu Tyr  Lys Val Asn Thr Gly  Ile Leu Gly Thr Pro  Tyr Tyr Thr 
    1130                 1135                 1140             


Glu Lys  Glu Ser Asp Gln Pro  Lys Leu Asn Leu 
    1145                 1150                 


<210>  7
<211>  1107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-78

<400>  7

Met Ala Asp Tyr His Thr Thr Trp Gly Phe Asp Leu Gly Thr Asn Ser 
1               5                   10                  15      


Leu Gly Trp Ala Val Ile Glu Thr Arg Gly Glu Pro Gly Gln Gly Asn 
            20                  25                  30          


Glu Gly Arg Ile Val Asp Ser Gly Val Arg Ile Phe Ser Gln Ala Glu 
        35                  40                  45              


Met Ala Gly Arg Asp Pro Gln Ser Lys Ala Ser Leu Ala Val Ala Arg 
    50                  55                  60                  


Arg Glu Ala Arg Gly Ala Arg Arg Arg Arg Asp Arg Tyr Leu Lys Arg 
65                  70                  75                  80  


Arg Arg Arg Leu Leu Asp Leu Leu Thr Gln Tyr Gly Leu Met Pro Val 
                85                  90                  95      


Asp Gly Glu Ala Arg Glu Lys Leu Val Arg Asp His Glu Asp Arg Lys 
            100                 105                 110         


Gly Gly Asp Leu Ser Glu Ser Val Tyr Ala Leu Arg Ala Arg Ala Leu 
        115                 120                 125             


Asp Thr Ala Leu Thr Pro His Glu Ile Gly Arg Ala Ile Phe His Leu 
    130                 135                 140                 


Asn Gln Arg Arg Gly Phe Lys Ser Asn Arg Lys Thr Asp Arg Asn Asp 
145                 150                 155                 160 


Pro Glu Gln Gly Lys Ile Ala Thr Ala Ile Asn Ala Leu Glu Ala Gln 
                165                 170                 175     


Met Ile Glu Asn Glu Ala Arg Thr Phe Gly Glu Trp Leu His Met Arg 
            180                 185                 190         


Arg Glu Gln Gly Leu Ser Val Arg Ala Arg Met Thr Ala Asp Gly Lys 
        195                 200                 205             


Gly Tyr Asp Phe Tyr Pro Ser Arg Ala Ala Leu Glu Arg Glu Phe Asp 
    210                 215                 220                 


Arg Ile Met Gln Thr Gln Lys Arg Phe His Pro Lys Leu Leu Gly Asp 
225                 230                 235                 240 


Gly Val Ile Ala Asp Ile Arg Glu Ala Val Phe Phe Gln Arg Pro Leu 
                245                 250                 255     


Lys Pro Val Leu Ala Gly Lys Cys Ser Tyr Asn Thr Lys Glu Thr Arg 
            260                 265                 270         


Leu Pro Lys Ala His Pro Leu Phe Gln Lys Phe Arg Leu Leu Lys Glu 
        275                 280                 285             


Val Asn Glu Leu Glu Ile Val Gly Glu Asp Gln Gln His Ile Lys Leu 
    290                 295                 300                 


Arg Pro Asp Gln Arg Asp Ala Leu Val Leu Ala Leu Arg Thr Asp Leu 
305                 310                 315                 320 


Asn Lys Gln Gly Lys Ile Pro Phe Ser Lys Leu Lys Lys Gln Leu Gly 
                325                 330                 335     


Leu Gly Lys Glu Ala Arg Phe Asn Lys Glu Thr Asp Asn Arg Ser Asp 
            340                 345                 350         


Leu Glu Gly Asp Val Ile Tyr Phe Arg Met Ser Arg Pro Glu Cys Phe 
        355                 360                 365             


Gly Asn Arg Trp Ala Asp Ile Thr Val Glu Asp Gln Ala Ala Ile Thr 
    370                 375                 380                 


Asp Lys Leu Arg Thr Glu Ala Asp Tyr Lys Glu Leu Val Arg Trp Leu 
385                 390                 395                 400 


Gln Leu Glu Ala Gly Leu Asp Glu Thr Gln Ala Lys Ala Val Val Gly 
                405                 410                 415     


Met Pro Val Pro Asp Gly Phe Gly Arg Leu Gly Pro Thr Ala Leu Ala 
            420                 425                 430         


Ala Leu Ile Asp Ala Met Glu Asn Asp Thr Asp Glu Asn Gly His Val 
        435                 440                 445             


Ile Thr Glu Ala Ala Ala Ala Lys Lys Ile Tyr Gly Arg Thr Asn Ser 
    450                 455                 460                 


Glu Ala Asp Pro Asn Arg Arg Gly Thr Ala Tyr Leu Pro Lys Tyr Gln 
465                 470                 475                 480 


Glu Val Leu Glu Arg His Ile Pro Pro Gly Thr Gly Glu Ala Asp Asp 
                485                 490                 495     


Pro Tyr Asp Glu Arg Met Gly Arg Ile Thr Asn Pro Thr Val His Ile 
            500                 505                 510         


Ala Leu Asn Gln Leu Arg Arg Ile Val Asn Ala Leu Ile Ala Lys His 
        515                 520                 525             


Gly Lys Pro Asp Arg Ile Ala Ile Glu Val Gly Arg Glu Leu Lys Leu 
    530                 535                 540                 


Asn Asp Arg Gln Arg Glu Ala Val Asn Lys Arg Ile Gly Lys Asn Thr 
545                 550                 555                 560 


Lys Glu Ala Arg Arg Arg Ser Ala Glu Leu Thr Asp Thr His Lys Ala 
                565                 570                 575     


Ala Asp Thr Gly Tyr Asn Arg Leu Arg Leu Lys Leu Trp Glu Glu Ile 
            580                 585                 590         


Asn Ala Asp Gln Pro Leu Asn Arg Pro Cys Val Tyr Cys Gly Lys Pro 
        595                 600                 605             


Leu Ser Ala Ala Met Val Leu Ser Ala Glu Thr Asp Ile Asp His Ile 
    610                 615                 620                 


Leu Pro Tyr Ser Lys Thr Leu Asp Asp Ser Gln Ala Asn Lys Val Leu 
625                 630                 635                 640 


Cys Cys Thr Ala Cys Asn Arg Glu Lys Lys Asn Arg Ala Pro Ala Asp 
                645                 650                 655     


Val Pro Gln Trp Arg Gly Arg Tyr Pro Asp Ile Leu Ala Arg Ala Thr 
            660                 665                 670         


Thr Leu Pro Lys Asn Lys Gln Trp Arg Phe Ala Glu Asp Ala Met Asp 
        675                 680                 685             


Arg Phe Gly Ala Glu Glu Gly Phe Leu Ala Arg Gln Leu Thr Asp Met 
    690                 695                 700                 


Gln Tyr Ile Ser Arg Leu Ala Leu Thr Tyr Leu Ala His Leu Tyr Asp 
705                 710                 715                 720 


Tyr Glu Glu Pro Asp Leu Asp Gly Val Phe Arg Arg His Ala Arg Val 
                725                 730                 735     


Arg Ala Leu Pro Gly Arg Met Thr Glu Met Leu Arg Arg Tyr Trp Ser 
            740                 745                 750         


Leu Asn Glu Leu Leu Pro Asp His Asn Leu Val Asp Ile Asp Leu Thr 
        755                 760                 765             


Arg His Lys Asn Arg Leu Asp His Arg His His Ala Ile Asp Ala Ile 
    770                 775                 780                 


Val Ile Ala Cys Thr Ser Arg Ala Leu Ile Gln Lys Leu Ala Thr Ala 
785                 790                 795                 800 


Ala Ala Gln Ala Glu Glu Lys Gly Ala Glu Arg Val Val Glu Lys Ile 
                805                 810                 815     


Ala Pro Pro Trp Glu Ser Phe Arg Glu Asp Val Arg Ala Ala Val Asn 
            820                 825                 830         


Asp Ile Thr Val Ser His Lys Pro Asp His Gly Thr Val Ser Arg Ala 
        835                 840                 845             


Gly Tyr Ala Asn Gly Arg Gly Gln Thr Ala Gly Lys Leu His Asn Asp 
    850                 855                 860                 


Thr Ala Tyr Gly Leu Thr Gly Glu Lys Asp Gly Lys Gly Asn Asp Leu 
865                 870                 875                 880 


Val Val Arg Arg Ile Leu Ile Thr Asp Ile Arg Lys Pro Ala Asp Ile 
                885                 890                 895     


Met Lys Ile Arg Ala Asn Glu His Gly His Ser Glu Leu Arg Asp Arg 
            900                 905                 910         


Leu Trp Gln Ala Thr Arg Gly Leu Glu Gly Lys Ala Phe Glu Glu Ala 
        915                 920                 925             


Val Leu Asp Phe Val Asn Asn Asp Ser Lys Phe Lys Gly Ile Arg His 
    930                 935                 940                 


Val Arg Ile Ala Glu Val Glu Ser Pro Val Trp Ile Glu His Gly Pro 
945                 950                 955                 960 


Gly Gly Glu His Arg Lys Gly Tyr Leu Pro Gly Gly Asn Asp Arg Tyr 
                965                 970                 975     


Glu Val Trp Glu Met Pro Asp Gly Arg Trp Gln Ala Glu Val Val Thr 
            980                 985                 990         


Thr Phe Asp Ala His Arg Pro Asp  Phe Val Pro Arg Met  Arg Gln Ala 
        995                 1000                 1005             


His His  Asn Ala Arg Lys Ile  Met Ser Leu Lys Lys  Gly Asp Met 
    1010                 1015                 1020             


Val Ala  Tyr Asn Asp Pro Asp  Ser Gly Arg Arg Ile  Ile Ala Ile 
    1025                 1030                 1035             


Val Arg  Lys Phe Asp Gln Arg  Asn Lys Gln Leu Tyr  Leu Asp Pro 
    1040                 1045                 1050             


His Asn  Glu Ala Gly Glu Leu  Asp Lys Arg Glu Arg  Glu Lys Thr 
    1055                 1060                 1065             


Tyr Lys  Pro Leu Arg Pro Met  Pro Asn Pro Leu Lys  Lys Tyr Arg 
    1070                 1075                 1080             


Pro Arg  Gln Val Arg Ile Asp  Glu Ile Gly Gln Val  Phe Asp Pro 
    1085                 1090                 1095             


Gly Pro  Trp Trp Glu Asn Arg  Gly Gly 
    1100                 1105         


<210>  8
<211>  1053
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OMNI-84

<400>  8

Met Asn Gly Leu Val Phe Gly Ile Asp Leu Gly Ile Ala Ser Cys Gly 
1               5                   10                  15      


Trp Ala Val Leu Arg His Pro Thr Pro Gly Asp Pro Ser Gly Lys Ile 
            20                  25                  30          


Val Ala Ile Gly Ser Trp Met Phe Asp Val Pro Glu Thr Asp Lys Glu 
        35                  40                  45              


Arg Thr Pro Thr Asn Gln Ile Arg Arg Gly Asn Arg Leu Leu Arg Arg 
    50                  55                  60                  


Val Ile Arg Arg Arg Ala Gln Arg Met Ala Glu Ile Arg Arg Leu Phe 
65                  70                  75                  80  


Ala Gln His Gly Leu Leu Gly Gly His Glu Pro Asp Ala Leu Lys Arg 
                85                  90                  95      


Ala Gly Leu Asp Pro Trp Glu Leu Arg Ala Arg Gly Leu Asp Lys Pro 
            100                 105                 110         


Leu Ser Pro Ala Glu Phe Ala Val Ala Leu Gly His Ile Ala Lys Arg 
        115                 120                 125             


Arg Gly Phe Lys Ser Ala Arg Lys Ser Lys Glu Ala Asn Thr Thr Gly 
    130                 135                 140                 


Asp Asp Gln Lys Met Leu Lys Ala Leu Glu Ala Thr Lys Glu Arg Leu 
145                 150                 155                 160 


Gly Arg Tyr Arg Thr Val Gly Glu Met Phe Gly Arg Asp Ala Glu Phe 
                165                 170                 175     


Arg Asp Arg Lys Arg Asn Arg Asp Gly Leu Phe Asp Arg Thr Gln Ser 
            180                 185                 190         


Arg Asp Asp Leu Ile His Glu Val Ala Lys Leu Phe Glu Ala Gln Arg 
        195                 200                 205             


Arg Leu Gly Asn Gly Ala Ala Ser Ala Glu Leu Glu Ala Asp Phe Thr 
    210                 215                 220                 


Ser Ile Ala Phe Arg Gln Leu Glu Met Gln Asp Ser Glu Lys Leu Val 
225                 230                 235                 240 


Gly Met Cys Gln Phe Glu Pro Lys Glu Lys Arg Ala Ala Lys Phe Ala 
                245                 250                 255     


Pro Ser Phe Glu Lys Phe Arg Leu Leu Gly Lys Leu Val Asn Leu Arg 
            260                 265                 270         


Ile Thr Ala Pro Glu Gly Glu Arg Pro Leu Thr Pro Glu Glu Ile Arg 
        275                 280                 285             


Leu Ala Thr Gly Asp Leu Gly Lys Thr Ala Lys Leu Ser Val Lys Glu 
    290                 295                 300                 


Val Arg Lys Arg Ile Gly Leu Pro Ala Asp Gln Arg Phe Thr Val Phe 
305                 310                 315                 320 


Lys Pro Glu Glu Glu Thr Gln Asp Ile Ala Ala Arg Thr Gly Glu Ala 
                325                 330                 335     


Met His Gly Thr Lys Lys Leu Arg Asp Ala Leu Gly Glu Val Leu Ser 
            340                 345                 350         


Ala Gly Leu Gln Thr Arg Pro Ala Gln Leu Asp Gln Ile Ala His Val 
        355                 360                 365             


Ile Ser Phe His Glu Thr Ala Asp Lys Ile Gly Glu Glu Leu Ala Lys 
    370                 375                 380                 


Leu Gly Leu Pro Gly Gly Ala Val Asp Ser Leu Ile Asp Asn Leu Lys 
385                 390                 395                 400 


Gly Phe Ser Arg Phe Lys Gly Ala Gly His Ile Ser Ala Lys Ala Ala 
                405                 410                 415     


Arg Ala Leu Ile Pro His Leu Glu Ala Gly Leu Arg Tyr Asp Gln Ala 
            420                 425                 430         


Cys Glu Ala Ala Gly Tyr Asp His Ala Ala Ser Arg Trp Ser Lys Arg 
        435                 440                 445             


Glu Gln Val Ala Asp Lys Ala Gly Phe Asn Ala Leu Val Gln Ser Met 
    450                 455                 460                 


Gly Asp Glu Ile Ala Asn Pro Val Ala Arg Lys Ser Leu Thr Glu Gly 
465                 470                 475                 480 


Leu Lys His Leu Trp Ala Met Arg Asn Arg Trp Gly Leu Pro Asp Ala 
                485                 490                 495     


Val His Ile Glu Met Ala Arg Asp Val Gly Asn Ser Leu Glu Lys Arg 
            500                 505                 510         


Asn Glu Ile Lys Arg Gly Ile Asp Lys Asn Thr Ala Glu Arg Glu Arg 
        515                 520                 525             


Gln Arg Asp Glu Val Arg Glu Leu Leu Gly Ile Glu Asp Val Asn Gly 
    530                 535                 540                 


Asp Thr Leu Leu Arg Tyr Arg Leu Trp Lys Glu Gln Ala Gly Arg Cys 
545                 550                 555                 560 


Pro Tyr Thr Asp Lys Ala Ile Pro Ala Thr Ser Ile Ile Ala Thr Asp 
                565                 570                 575     


Asn Ser His Gln Val Asp His Ile Leu Pro Trp Ser Arg Phe Gly Asp 
            580                 585                 590         


Asp Ser Tyr Ser Asn Lys Val Leu Cys Thr Ala Arg Ala Asn Gln Glu 
        595                 600                 605             


Lys Lys Gly Gln Thr Pro Phe Glu Trp Ile Met Ser Ser Gln Gly Glu 
    610                 615                 620                 


Asp Ala Trp Asn Thr Phe Leu Ala Arg Ile Glu Gly Asn Thr Ala Phe 
625                 630                 635                 640 


Arg Gly Ala Lys Lys Arg Asn Tyr Val Leu Lys Asn Ala Lys Glu Ala 
                645                 650                 655     


Glu Glu Arg Phe Arg Ser Arg Asn Leu Asn Asp Thr Arg Tyr Ala Ala 
            660                 665                 670         


Arg Leu Leu Ala Glu Ala Val Lys Leu Phe Tyr Pro Glu Gly Asp Arg 
        675                 680                 685             


Gln Glu Lys Gly Gly Ile Arg Arg Val Phe Thr Arg Pro Gly Gly Leu 
    690                 695                 700                 


Thr Ser Ala Leu Arg His Ala Trp Gly Val Glu Ser Leu Lys Lys Val 
705                 710                 715                 720 


Ala Gly Lys Arg Val Glu Asp Ala Arg His His Ala Leu Asp Ala Leu 
                725                 730                 735     


Val Val Ala Ala Ile Gly Glu Trp Glu Val Gln Arg Leu Thr Arg Ser 
            740                 745                 750         


Tyr Gln Glu Trp Glu Gln Lys Gly Leu Ala Arg Pro Leu Arg Gln Val 
        755                 760                 765             


Asp Pro Pro Trp Gly Asp Ala Ala Ser Phe Arg Arg Glu Val Lys Glu 
    770                 775                 780                 


Ala Tyr Gly Lys Val Phe Val Ala Arg Pro Glu Arg Arg Arg Ala Arg 
785                 790                 795                 800 


Gly Glu Gly His Ala Ala Thr Val Arg Gln Val Lys Glu Arg Asp Gly 
                805                 810                 815     


Ala Leu Val Val Tyr Glu Arg Lys Ser Ile Thr Asp Leu Ser Glu Lys 
            820                 825                 830         


Arg Leu Gln Asp Ile Lys Asp Pro Glu Arg Asn Gln Gly Val Ile Glu 
        835                 840                 845             


Ala Ile Arg Glu Trp Ile Ala Asn Gly Lys Pro Thr Asp Ser Leu Pro 
    850                 855                 860                 


Arg Ser Pro Ala Gly Asp Glu Ile Arg Lys Val Arg Leu Arg Thr Lys 
865                 870                 875                 880 


Gly Lys Pro Ala Val Gln Val Arg Gly Gly Thr Ala Asp Arg Gly Glu 
                885                 890                 895     


Ile Val Arg Val Asp Val Phe Ala Arg Pro Asn Lys Arg Gly Lys Asp 
            900                 905                 910         


Glu Phe Tyr Leu Val Pro Ile Tyr Pro His His Val Met Asn Lys Arg 
        915                 920                 925             


Asp Trp Pro Thr Pro Pro Glu Arg Ser Val Val Ala Tyr Lys Asp Glu 
    930                 935                 940                 


Asp Glu Trp Thr Leu Ile Asp Asp Arg Tyr Lys Phe Lys Phe Ser Leu 
945                 950                 955                 960 


His Pro Arg Ser Tyr Ile Glu Val Thr Lys Pro Thr Gly Glu Leu Leu 
                965                 970                 975     


Ala Gly Tyr Phe Gln Gly Leu Asn Arg Ser Thr Gly Ala Ile Asn Leu 
            980                 985                 990         


Ser Asn Pro Arg Asp Pro Arg Leu  Leu Ala Asp Asp Asn  Gly Asn Ser 
        995                 1000                 1005             


Met Gln  Ser Ile Gly Ala Lys  Thr Leu Leu Thr Met  Lys Lys Tyr 
    1010                 1015                 1020             


Asn Val  Asp Arg Phe Gly Val  Cys Ser Glu Val Lys  Ser Glu Val 
    1025                 1030                 1035             


Arg Thr  Trp His Gly Val Val  Cys Thr Ser Pro Ile  Pro Pro Asp 
    1040                 1045                 1050             


<210>  9
<211>  3609
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 Original ORF

<400>  9
atgaaaaaat ataaacttgg attagatgtt ggggtctcgt ctgttggcgt tgcagttata       60

aaagaagaaa acggaaagtc atcagttgaa aaattatctg tgagaattgt tcctgaagac      120

cctaattttc atgggaaatt ctactccgga aatacagcaa gcaaaaacct tgatagaact      180

attaaaagag ggattagaaa aaataatcag agatttaagg caagacggga taagctttac      240

cagactttga gagaaaataa tatgtttcca acggataatt tattcgatct tcctgcaact      300

gaactttacg gattgagggc aaaagctgtt tcgaaaaagg tttctttaga agaattgggt      360

agaattttta tagtactgaa ccagcgcaga ggatttttaa gtaatcgaaa atctgtttcg      420

gaagaagaga attcaaccga atataaagaa tgtattgcta cacttgaaaa agaattggct      480

ggtagaacta ttggacaaaa gttatattca gaactggagg aaagcgagag tgattttgaa      540

gtattattac gggaacggac ctatcaaaga agttcatata tagaagagtt tgatagaatt      600

tgggacgagc aaaagaaata ctattctgtt ttaacaggtg gagcgaatga agataataat      660

aaagaaacat tgtacgattt aatccgaaat agaattattt attatcaacg tcccttgaaa      720

agtcagaaag gtttaatttc tgaatgttct tttgaaaaat atcacaaagc gacagcaaag      780

agttcccctt attttgagtt gttcaggatt tggcagaaag taaatgattt gtcgtggaaa      840

actccaggtg gagagacttt taaaccgaca cttgggcaaa aacaaaattt gaaagaagct      900

ttatggaatg gagaaaatct taatgctaaa cacaaattat cggtaactga aattaaaaag      960

cttttaggtt acggaagaaa cgaaaaaata tatctgaatt ttacagaatt agatggaagc     1020

agaacctata cggtattaaa aaatgctttg gaagaggcag gaatagaaaa ctttcaacaa     1080

tacttattct ttaatttgga tataagcgat gaaaaaggag gtttatttga attgtggcat     1140

attacctatt cattgccaac ggaaaaagag gtggtaaatg cattaaaaaa tcgtttcgga     1200

ttttctgaaa atcaatcgga aattattgct aaaaaagttg ggtatccttc taattatgga     1260

aatctttcaa ctcgtgctat ccgaaaatta cttccatatt tggaaaaagg gttaggttac     1320

agtgaggctt gtgatgcggt tggctacgac cacagtggat ataaaacaga aatagaactt     1380

aaaccgaact taaagcagct taaaaagaat gaactgagaa atcctgttgt ggagcaaatt     1440

ctaaatcagg ttgtaaatgt tgtaaatctt gttattgaga agtatggtaa aattgatgaa     1500

ataagagttg aactagcgag agaactaagg aataatgcga aaactcgaaa aaatatttct     1560

caggcaaatt caaaaaacaa gaggaataat gatgttataa gaaaaaaact tatagaagag     1620

tatggattca ggttagtgaa tggacgggat gtaaagcgtt atattctttg ggaagaaact     1680

gctcacgaat gcttgtattg taataatcct attaatggaa cagatatgct tacgggtaat     1740

gcggatattg agcatgtttt accaaaatcc cgttctttca gcaatgcgat gaataattat     1800

attatagctc acagaaaatg taactccaat aaagggcaga aaaccgctta tgattttatg     1860

gagtctaaag gagaagaagt attagggcaa tatatagaaa aagtaaatgc tttgtataat     1920

gatggaaaag gaagtatttc aaaatctaaa tttgataatt tgttatgtaa aggagaagat     1980

attccttctg attttgtaga aagaatgaaa aaggattctc aatatatttc caaagaagtg     2040

gtaaaaatgc taaaaaccgt ttgtccgaat gtttatacta cgactgggca ggtaactgat     2100

tttttacgtg aagaatggaa attgaaaaat ctgttacagg aattaacttt cgacaaatac     2160

aaagccattg gtcaggttga ggaaaagacc ataaaaacaa agaatggaca aactaaaacg     2220

tttgaaacaa ttacagattg gagcaaaaga gatgaccaca gacatcatgc tgttgatgcc     2280

ttgatttgtg ctttaaccaa ccaaaaaatc atctttaaac tcaataatct caacaaaatt     2340

tatcaatatg aaagagatgc attgagccaa aaagaaatag aggagtttga agaattttta     2400

gaaggaaagt tttctctgaa agaattttcg acacaacagg aaaatatcat agaatgttct     2460

ataccaaata ttcgcagaga agttcaaaag catctcgaag agatttttat ttctttcaaa     2520

aaagagaata gcaaagttct tacaaaaaat atcaatgcac ctaaaaatgt agaaccgaaa     2580

acaacttggg tcccacgtgc aagattacac gaagatacta ttatggggcg tgtgaaacgt     2640

attgccgaaa agaaaatgaa actcagtgat aaagtttcaa tggaagaaat cgaaatggtt     2700

gtaaatcctg aaatcaaaga aatactttat cagcatctta cgaaatttga caataatccg     2760

aaaattgctt ttgctcaaaa aacgctgaaa ggagaactga tttcttataa gggcaatgaa     2820

ataaaagaag ttggtgtgta tgaatgggtg aatacaaaaa gagtaaatgt tgagaatttt     2880

ttaacagata atcaaaaaac gacgtcagct aaggacaagt ttatagaaaa tattctaaaa     2940

tcggataggg gaataggagt tttattagat agacgattaa aagagtttaa tggagattat     3000

aaggaggcat ttaaaaattt atctgaaaat cctatcatta ccaaaaatgg aatgattgtt     3060

aaaaatgtaa caatttatga tgaaagcaag gtcgagagag taagaaatgg ttacgcaaaa     3120

acaggtggaa atcatcatgc tttaatctat aaagataaaa acggaaaata caatgataaa     3180

gtagtttcat tttgggaagc ggtagaaatc gggttattaa acatagcggt acaccataat     3240

ccttatccga ttatcaatag aaatgacaat gaagaatttg gaactttcca attttctatg     3300

caaatcaatg atttatttgt atttgattta aaacattctg ataatcctca ggaagaaaat     3360

gaaatcgact tttttgatgt gaagaacaga aagttgattt caaataactt gtttagagtt     3420

cagaaaatga caaagaaaag ttctggagct tttgaagtaa catataggca tcatttagaa     3480

gcaaatctta atagaagtga taaaatttta aagggatata cctgggatga acacggttca     3540

aataaacatt tggaaagatt aacaaaaatc agaattaatc atcttggtga aattataaaa     3600

atcggagaa                                                             3609


<210>  10
<211>  3159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 Original ORF

<400>  10
atgattagat tggaatccgg tatggataaa gccaagggag cagatatcgg agagctcggg       60

ttcgaccccg caaccttcgc cacggcgctc atgacgctcg aggagttcag atcgaaggac      120

agggtgatct gggcgggtct cgatatcggc gtggccagta ctgggctgtg tctggtcgat      180

gtccgcaacc atgagatcgt cctgatggcc agccacctct tcaagtcgcc cgtcgtcgac      240

aagaagaagg cgaccgcggc gcccgagagt ctggcgtcgg taaggcgtgg agcccgctcg      300

gtccgtagga acatcatgcg cgaggggcgg cgtaagaagg ccatcagggc tgcgttagct      360

gattttgacc tcattcccgc cgatactgac ggcgagtggt ttagcgcacg ccgcgacgag      420

cgtacggtcg tcaggctgag atccaaggct ctcggttatc tgctgaactc ccgtgagctc      480

gcccgcgtgc tgtactcatt cgcgagccat cgcgggtata tcgaccacgg caagtccgat      540

aaagaggacg atgccggcaa ggtcaagaag gcacttgccg cgaatcacgc ggcgctcgcc      600

gatggtggct gcaagacctt cgggcaatac cttgccggac agccgcgctc gcgcaacagg      660

gccggcgact atagctatac ggcagacatc ggcatgactg tcgacgaggt tcgcacgatc      720

ttcacacgcc agcgcgagct aggcagcgaa atcgccagca aagcgcttga ggagcgctat      780

atcgccgagc tgacgtggct caccgatacg agtaagcgtg acaggtcgac ctacctcaag      840

gtgggtttct gcacctacct cggcgcgccg tacagacgcg gggccacttc cacaatctcg      900

ttcgagatgg tacgtgcaca ccagacgctt tgcaacacgg tcatcctgca tgccgacggc      960

acctcgtcca ccatcccggg cgacatccgc atcgagatcg tgagggagct cttcgacgtg     1020

aagagatcgg tgaagccgtt gaaatggtcg gggctgcgcc gcaggctggg gctcgctgag     1080

tgcgattcgt tcaaggggcg tcccgccgag gaggagaagc gcgactgcat cgccctgccg     1140

gcctgggccg tgctttgctc ggggctctat gagaatcatc gcgatctgct cgagcggctg     1200

catgaccata tcgacgacgc cgacgcggtc tgctcggcgc ttaccttcgc atcgtcggcg     1260

gcatcgcttg ccgggcggct cgccccgctg gccctcaccg acgacgaggt cgaggctatc     1320

atcgacctac cctattcggc gcgcctgttc tcgggctatg cgaacgcgag cccggaagcc     1380

ctccagatgc tacgcggcac gttcgaggat ccccgcgtca catcactcag acaggccgag     1440

gaggattccg gcctcgcgca ggcgcgtgcc atgctcgccg aggagcgcgg tgggtcggcc     1500

gacgggctgc tgtgtgcctt ctccgattac gacccgacgt gcaggaaccc cgttgtgctc     1560

cgcgcgacgg cgcaggtgcg gcgcatggtc aactccgtca taagacacta tgggctgccg     1620

gatgtcatcc gcgtcgaggt cgcccgtgac ctcaagcgct caaagcacga gcgcgagatc     1680

gttgcggaga gcaacagggc gaggctcgag ctcaacgaac aggccaagag ggatatcatc     1740

gagttccttg ggcttcccga cgaccaccat gtgcgcggcc gggacctcgc cttggtcaag     1800

ctctaccgcg agcagggcgg caaggacccg tatacgggcg ccggcatcga ctttaggcgc     1860

atgctcgagg aacacggata cgccgagatc gaccatatcc tgccggtctc gcgcacctgc     1920

gacgactcgc aggcaaacaa ggtactctgc ctcaccaagt cgaataggga caagtcgaac     1980

cgctctccct acgagtggat gacctctggt gaagcctcgg cgcctgattg gggcgagttc     2040

tgcggcagga tggagcgctg ggcgaaaatg tgcgagacca ggcggtacgc ccgaaagaaa     2100

ctcgccaacc ttacctgcga gaaccttgcc gagcgcgccg ataatttcat tgaccgcaac     2160

ctcaacgaca cgcgctacat gtccgtagcg ctcgccaagt ggctaaggga gtgtctgccc     2220

tttactaagg acgggcatga gcatgtgttc tgcgtagccg gtggcgcgac cgccctcatg     2280

cgcagtgtct ggaacatcgg tatcaccggg ccagacggca agaagaaccg cgaagacgat     2340

agacaccatg cggtcgatgc cgcggtcatc gcctgctgca cccccggcat cgtgaggaac     2400

gtggcgctgg tcaacgaggg ccatgcccgc gccgacgtgc gtcagcggct tttcagcgac     2460

tcgcttccct atccggagtt caaggagcag gtagatgcct ggatcccgtg tatcgtgccg     2520

acgctcacac ttccgaacac cgtcacaggc agcgtgctca aggacacggt ctatccttat     2580

ctgggtcgcg acgaagccgg caaggacctc tacatcaccg tcaagaggga caaggacggc     2640

aggattgtcg aaaggaaggt caacaaggcc accacgatgt ggaaggacgg acagggcggt     2700

tgccgggcct atgggtccat gtgcgccctg gaggctgtgt tcgacgcctc ggccggcaag     2760

cgcggcaggt ggtcattcga cccagtctac tgcatcgata tcccacaccg tgatgctgag     2820

aggcgaacca tgagggcgtt ttccaaggag aaggcgattg atctgtggga tacggtcgcg     2880

gtgcccgagg ccgcgccgcg gatgacgatc cggcgcggcg atgtgctcgt gtgcgacggg     2940

aaggccgcga ggttccattg ctttgatatc tctgtcaatg ccatcaggtt attctctcaa     3000

cgcggcggta aacagctcca ggcaaccggt cctctttctg ccgaggcatt cccgcctccg     3060

tcgaagtggg gcgagggcgt caggatcatg caggaggact gccttggtct ctgctggctg     3120

tcgttcttgg cacagcgggc cgtggacgcg cagatggaa                            3159


<210>  11
<211>  3432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 Original ORF

<400>  11
atgcactata ttttgggtct ggacgtgggg attcagtcgg ttggatgggc tgtgatccga       60

tacgatgagc ctgcccgcat cgaggatttt ggggtgcgca tctttgatac caccgaaaat      120

cagaaatcca aggacaacac caaccaggag cgccgggctt ttcgggctgc aagacgtgtg      180

ctgcgccgcc gaagccatcg cagagcaatg gtgaaacggc atttacagag aattggcctg      240

ctgcgggaag gtgaggtgga agccttcttt gaatccggtc agtccgaccc gctgcgcctg      300

cgggtcaaag gtttgaccga acagctgaca ccggctgagc tggcagcctg cctcattcac      360

atcagcaacc acaggggcta ccaggctttt tataacctga ccgaagaaga actcaaagag      420

ctgcccgcgg cagagagaaa agagtaccag caggagcgca gtggcattga gctggtggaa      480

ggcatcatgg agcagggaca ttatcgctcg gtggcggaaa tgctcttgac tgacgacacc      540

tttgccccgg atcatgccgg gccaatgcgg gtataccgaa gccatcccta tctggatacc      600

cgttacccca tcagtcggga cctgctgcgc aaagaggctg acgccattct caccaaccag      660

gcccggttct acccctgtct gaatgcgcct taccagacca cctggcgcaa agaatccaaa      720

accaccacca accgcgcatt tctggaatgg ctgattttca cccagcggga ttttgaggac      780

ggccccggcg accgggatga cgccatgcgc aaatacaccg gctttttgca ggctctgggc      840

aagtgtccct tttaccgcga ggaagaccgc ggtccccgga tgaccgtact gggggacttg      900

tacgctctca ccaactctct gtcccagtat cagtacatga acaccgaaac aggtgtcttt      960

gaactgccca aagaacttgc cgaagcgatg ctggctgcag ccctgcggga tgccgaactg     1020

cccgccaaaa agattcagga gctggccaag cgttaccaca tcaaggtgga caacaaagcg     1080

gtaaaaaccg ccgaccgtgc tcccaactgc atcaagttcc tgcgccgggt ccgtcccatt     1140

ctggagaaat acggcatcaa ctgggaaacc gctctgggcg gcaccaccct ggaagacgtt     1200

ctggccgatg acaccatgct caaccagatc gggcgggttc tgtccctcta ccagacgccc     1260

caccgccgcc aggaagaact ggtgaaaatt cctggtattt caccggaact ggcaaaacgg     1320

ctgacggcgg aacggatttc cggcaccgcc aaagtcagcg cccactatat gcgggatgcg     1380

gtggaagcct ttcagaaggg cgagcgatac ggtgaatttc agtggcgccg gatgaacgag     1440

ctggagcagc ctctgcccgg tcaggccagc ggcgcccatg tcaaactgcc gcccttcccc     1500

gtcgatgccg agtttgccaa gaactcggtg gtgatgcgca gcctcaacga aacccgtaaa     1560

atcatcaacg ccatcgtggg gcaatacggt tccccctggg cggtgaatgt ggaagtggcc     1620

agcgatctgg gccgctcctg ggccgagcgg gccgaactgg accgccggaa caagcagaac     1680

gaggcccaga ccgaaaaaga caagcagcaa atctgccaga tcatgggata tgacagccct     1740

gaccaggtca agggttccat ggtggagcgg ttccagctgg cgcagcagca aaactggcag     1800

tgcctgtata ccggccggcc cattacagac aagcgggccg ccctcgaccc caaaaacaag     1860

ggctttgaag tggaccatat cgttccattt tccatgattc tggacaacac cctccaaaac     1920

aaggcgctgg tctatgccga tgccaaccag accaaggggc agcggactcc gctgatgtat     1980

ttgcgcgatc ccgcacagcg ggagcagttc attgggcggg tcaaccagat ggccaagaac     2040

catatcatca gcgaccggaa gcggcaatat ctgctgctgg ccgatctgta ccatacggat     2100

cttctggacg agtggaagag ccgcaacctg aacgataccc gctacattgc caagtacctg     2160

cggggttatc tggagcggga actggccccg gccccagagc accgcacgcc ttttgtgttt     2220

ccggttaaag gcggcctgac cagccggttt cgccggacct ggctcaaccg cagcacctgg     2280

ggcggagatg aaaaaagtga actccgcgaa tccaccacct tgcatcacgc agtggatgcc     2340

gtggtcattg ccaacatctc tcctgccacc gcgcagattg ccgaggacaa cctgcgcctg     2400

aaccgcattc tgaaaaatag ccgcggcatc gaaagacccg aataccgcgc ccagctggag     2460

cgcagcctcc aaaccctgga acaattctac catgttcccc gcacccgcgg ggaagcttgc     2520

ctcaagcgcc agaatcggat taccgcgctg atcgccaacc tgaacatcga ggtggatatc     2580

cgtttcggcg tccccggcca gaccaccgac cccgacagct accgcagcct ggtgacgaac     2640

ttctatgctg acgacccgga ttttgccgcc cgcctgaccc agcccctcac cagccgcaag     2700

ccggaacgca aactgcaggg caccctgacc acggccaacg ctctgggaac caaagagatc     2760

gacggcgttt tgtatgaggc caagcgcacc gacgtaatga agctgaccca aaaaaatctg     2820

tcccagctct gcaccaacga cggcgacctg cgggactctc tcgctgagct gctggctgac     2880

gccggaacca gaactctggc ggatgtgctg tcggagcagg gcaagaccga attccgcacc     2940

caaaagggcc agctcattcg caaagttacc ctgaagggca gcgtggtgga tcagtacaag     3000

atcaagcaga ttgcacccaa caattactcg gttctggata cgaccagcta ttactgcacc     3060

gaggtctacc gggatcctgc cggcaaaacc agagtgcggg ccattgcccg ggccagtctg     3120

gtctgcaaag ggaaaaaact atggctgacc tgccccaacc ctgccgacta cgctgagcac     3180

atcatgtacc tgttcaagaa cgactacatc cgtgtagaaa ctcccaacgg gctgcaattt     3240

gaaggtttct accagagccc ggccggtatc aagcaggcca aattcaacgg catcaaaaat     3300

aatgacgcta aaagctgtcc attccacatt tccggcggcg ctgttgtcaa aaaatatgac     3360

atcagcattc tgggcagaaa aggaggcgag attccatgtg gcgaaccctt atcgttactg     3420

ctggagaaaa aa                                                         3432


<210>  12
<211>  3462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 Original ORF

<400>  12
atggttgtca acatggaagg agtatcaatt atgcactatg ttttaggtct ggatataggc       60

attcagtctg tgggctgggc ggtaattcgc tatgatgagc ctgcacgcat tgaagacttc      120

ggcgtacgca tatttgacac cacggaaaat agaaaatcca aagataacgc caatcaggaa      180

cggcgtgcgt tccgggccgc aagacgggtg gtgcgtcgcc ggagccaccg gagagagatg      240

ctgaaaaagc atctacaacg aatcggtctg ctccgagaag gcgaagtgga agcattcttt      300

gaatcgggca aatccgatcc gctgcgtctg cgggtcaaag gactgaccga acagctcaca      360

ccagtagagc ttgcggcctg tctaattcac atcagcaacc accggggata tcaggcgttt      420

tacaatctga ccgaagaaga actgaatgaa ctgcccgctt ccgaaaagaa agaatatcaa      480

caggagcgca gcggaatcga gcaggtgacc ggccttatgg agcagggcaa ttaccgttct      540

gttgccgaaa tgcttctgac cgatgccgct tttgcctcgg aagatggcgg accgatgcgt      600

acctaccgca gtcatcctta taaagatact cggtatccca tcagccggga tctgctgcgt      660

aaagaggcag acgctattct gatgaaccag gcacaattct acccttgcct gaatgaagct      720

taccaggtga cctggcgcaa ggaaagccgt acgccgtcca accgggaatt tctggaatgg      780

ctaatgtttg agcaacggga ttttgaagat ggccccggtg accgtgacga tgccatgcgt      840

aaatacacag gctttctgca ggccttgggg aaatgctcct tttatcggca ggaggaccgc      900

ggcccacgca tgagcgtgct gggggatctg tatgctctga ccaactcact gtcacagtat      960

caatatatag atgaaaaaac ttctgcattc ggtatgccca agacactggc caatgatctt     1020

ctggaggcag cattgcatga tgcggaattg cccgcaaaaa gaatccagga actcgcaagg     1080

aaacacagtg tcaaaatcga taacaaagcc gtaaaaaccg cagaccgcgc gcccaactgc     1140

atcaaattta tgcgccggat tcgtcccatt ctggagaaat acggcataga ctgggaacag     1200

gctcttgggg gagccactct ggaagaagcg ctggatgaca acacgatgct gaatcggatc     1260

gggcgggttc tgtcgctcta tcaaaccctt caccgccgca aggaagaatt ggtgaaaatc     1320

cctgggattt cgccggagct ggcatcccga ctgactgcag agcggatttc cggtacagca     1380

aaggtcagcg cccattacat gcgggacgca gtggaagcct ttcagctggg cgagcggtac     1440

ggtgaatttc agtggcgcag aatgaacgaa caggagcagc ccctgcccgg tcaggccagt     1500

ggggcgaatt tcaaattacc cgccttcccc gccagtgccg agtttgcaaa aaactcggtg     1560

gttatgcgaa gcctcaacga aacccgaaag gtgatcaacg cggtcattga acgatatggt     1620

tctccctggg ctgtgaatgt agaggtcgcc agtgaactgg gccgctcctg ggccgaacga     1680

gacgagctgg atcgcaggaa taaacaaaat ctggctcaaa ccgaaaaaga caaaaagcaa     1740

atttgtgaga tcatgggcta ccacagtccc gatcaggtga acggttccat gctggagcgt     1800

ttccgattgg cccagcagca aaactggcag tgtctgtata ccggcaaacc gatcacggac     1860

aaacaggctg cactggattc caaaaaccga agctatgagg tagaccacat cgtaccgttt     1920

tcgctgattt tggataacac ccttcagaac aaagcgctgg tctgtgccga tgccaaccag     1980

accaaggggc agcgcactcc gctgatgtac ctgcgtgacc ctcagcagcg ggaactgttt     2040

atcggacggg tcaatcaaat ggccaaaaac catgtgatca gcgaccgaaa acgacagtat     2100

ctgttgttgg agcatctggg aaacagtgag cttctggacg aatggaaaac ccgcaatcta     2160

aatgataccc gctatattgc caagtatctg cggggatatc tggaacggga actggcaccg     2220

gcggctgagc accgcacgcc ttttgtgttt cctgtcaaag gcggcctgac cagccggttc     2280

cgccgcgtct ggctggaccg ggaaacctgg ggcggagatg aaaaggggca gctgcgtgag     2340

acgactaccc tgcatcatgc ggtggatgcc gttgtgatcg ctaacattac cccggcgacc     2400

gccttgatcg cggaagacaa tctgcggctg aaccgcatcc tgaaaagcag ccatggagtg     2460

gaaactgcag aatactgtgc ccagctggag cgcagcttgc aaacgctgga acagtattat     2520

cacattcccc gcgccaaagc gcaggcctat ctcaagcgta aaaaccggat cactgcactg     2580

atcccaaccc tgaatatcga ggtaaacatc cgctttggtt ctcccggaga agaaatcgac     2640

ccggacacct accgcgcttg tgtgctgtac cattatcacg acgatccggc ctttgctgcc     2700

ggcctgaccc cgccatgcac cagccgcaaa ccggagcgaa aggttcaggg cggcctgacc     2760

actgccaatg cgctgggaac catggaaatc gacggcgttt tgtatgaggc caaacgtgtc     2820

gatgtaatga agctgagctg gaaaaatctc tcgcagctct gcaccaacga tggggatctg     2880

cgggactccc tgatcgaact gctggccgaa accggggaca aaaagctgga agatattctg     2940

tcggcgcaaa acaaaacgga attccgcacc cggaagggcc gcctgatccg gaaggtaacg     3000

ctgaaaggca atgtggtaga ccagtaccgc gtcaagcaga ttgcgccaaa caactattcc     3060

gtcctcaaca ccaccagtta ttattgcacc gaagtctatc gtgacactgc cggaaaaaca     3120

aaagtgcggg caatcgcccg ggcggatctg gtgcgcagag acaaaaagct gtggcttacc     3180

tgtcccgccc ccgccgacta tgccgagcac atcatgtacc tgttcaaaaa tgattatatt     3240

caggtgcaaa cacacaatgg ggtgctcttt gaaggatttt accaaagccc ggcaggcatt     3300

aaacaagcaa aattcaatgg aattgagaag aatgcttccg gttcccgtcc gttccgtatt     3360

tccggaactg ccactgtaac aaaatacgac atcagcattc tgggcaaaaa aggaggcgaa     3420

attccatgtg gcgcaccctt atcgttactt ccggagagaa aa                        3462


<210>  13
<211>  3159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 Original ORF

<400>  13
atgacttggc gattagggct ggatgtcggg acaaattctg ttggctgggc agcgcttggg       60

ttgggtccga ccgggcccga aactctcatt ggtacaggcg ttcggatttt ctcggacggt      120

cgcaatccca aggatggttc ttcgctcgcg acaaagaggc gcgaacctcg atctgccaga      180

cgaaaccgtg atcgttatct gaaacgtcgt agcgagttca tggagcgact tgtcgcattt      240

ggcctgatgc caaaggacga atccaaacga aaagagttgg aacatctaga cccctggata      300

ctccgctgtc gcgctctgga tgaacccctg acagctcatg aaatcgggcg tgcgctcttt      360

caccttcaac agcgccgggg ctttaaatcg aaccggaagg cggatcgggg agatagtgac      420

aagggtgcaa tcgctgaggc ccgagaacga acactcgaca ggcttgcaaa tgaaggcgcg      480

cgaactctgg gtgaactgtt tggtcgcagg cgcatggacg ccgcgcaaaa taatgcggta      540

acgtcaaagg gtgcacgcca accacaaccc gccgccagag tgagtcctta tcaagacggc      600

gcaaagcttg cctatgatta ttatccgaca cgcgaactga tacagcagga attcgatcta      660

atctgggagt cacaggtcag ttttcagggc aaagacacgt tgacagacga cgcccgtaac      720

gcgcttgcag acacgctact ttatcagcgc aagttgaagc ctcagccggt gggtaaatgt      780

tcgctggacc ccacccagac gagagcagaa cgcgccctcc cgtccatcca aaggctccgt      840

atttatcaag atgccaacca ccttcatgtg ctggttacag gagagccatc gcgttcactg      900

acgcttgaag agcgcgacat tgtcgtcgac aggcttctcg ggtcggcaag agtttcgttt      960

tctggtctgc gcaaagcatt gaaactcccc gcagacagtc gcttcaatct ggaaagcgag     1020

aagcgcagct ttctcttagg cgatgaaaca gctgccgaac tcgccaagga gaagcgctgg     1080

ggcaaagaat ggcggaaaat gcttttcgcg gaccaagagc gaattgtgcg tcagttgctg     1140

gatgtggaag aagaagaaga actgagacgc tggctgacag acgaattcgg tctaggcgca     1200

acggaagcaa atgccgtttc agatgcctcg ttgccagaag gtcatgccgc tatctgttcc     1260

gacgcagccg ggcggctact tacagcgctt caaggtgcgg tgatcaccta tgacaaagcg     1320

gtcattgagg ccgggtttct gtcacattcg cggctggatc atcatggcga aattctggat     1380

cgcctcccct attacggcaa ggtgctacag cgacacgttg cctttgggag tggtgaacca     1440

tctgacaagg cggaaaagcg atacggcaag gtcgccaatc caaccgtcca tgtggccctc     1500

aaccagattc gacatgttgt gaatgatctg gtcagacgca ttggatcgcc tgaagaaatc     1560

gtcattgaac tcgctcgcga tctgccgcta tcggctcaag gcaaacggga tcttgagaaa     1620

aggcaacgcg aaaaccagaa tgcaaacgaa aaaagacgag aggatttgag gaaactcggt     1680

cgatctgaca cctatgaaaa ccgaatgcgg ttgagattat gggaagaact taatcccgaa     1740

aacgttcttg atcggaaatg cccgtttacc ggcgaacaaa tcggaattga gcgccttttt     1800

tctgatgagg tcgagataga gcatatcctg ccgaagtccc gaacacttga tgatagtccg     1860

gcaaacaaga cgctgtgcat gcgctctgcc aatcgagaga aacgcgagcg gtcgccctat     1920

gaagctttcg gttcttcacc cggctcatat tcatggggtc atatcgtcgc gcgggcagct     1980

aatatgccga gtaataaatc ctggagattt gcacccgacg ccatggatcg gtttgaatcg     2040

gaggaacgtg actttctgga ccggcagctg agctccacgc aatacatagc gaggctgaca     2100

gccaattatc tggtctggtt ggtaggcgac cccggaaagg ttcatgtcac ccccggacgt     2160

ctgacaagcg acctacgaca tcattggggg ctaaattctg ttctgcgcgg acacaatgag     2220

gccgagccgg aggcgattgg tcagaagaag aaccgcaatg atcatcgtca ccatgcgatt     2280

gacgccattg tggttgccct caccgacaga ggccttctaa agaaaattgc aactcaggcg     2340

gcccggaatc aatccaatag tagcgggcaa cttattgata caatcgacac gccatgggcc     2400

agctttcggg atgatgttgc agcttgcctg tcgtcgatca ttgtctccca caaggcagat     2460

catggcgtac agggcgcact tcacaatgat accgcctacg gattagcaag cgacgctgac     2520

aagaccggta aacgggacgt tgttcatcgg gttccggtag caagccttga taccctcaag     2580

aaaatcgaac aggtgcgcga tccgctcatc cgtgatgcgt tcatggatgc cgcagcggga     2640

ttaaccggca aggacgttgt gacagccgta gtgaccgctg gcgaggccat gacgcctccc     2700

gttcgtaaag tccgagtgct ggagaggatg aacgttatcc ccatcaatga caaagatggc     2760

caaacataca aagcctataa gggcgacgga aattattgtt acgatattta cgcgaatgaa     2820

aagggtggat ggaccggaga ggttgtctcg cggtttgacg ccaatcagcc gagctttgag     2880

gccaatggat ctatttcgag aagcggcacc cctttgatca tgcggattcg cggcggcgat     2940

acgttattga ttgatcaagg gcaaggcgaa cgtttcatgc gcgtggtcaa gttcagctct     3000

ggtatgatct gtcttgctga acatttcgag gcaggctcgt tgaaggctcg cgacaccgat     3060

caacatgatg atttcaaata tttaattgtc gcgcccagtc gcctgcaaaa ctggggcgct     3120

cagatcgttc atgtttcgcc ctccgggcat gtattccgg                            3159


<210>  14
<211>  3462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 Original ORF

<400>  14
atgacaaagt atagtgtcgg tttggacatc ggtatagcaa gctgcggctg gagcattatt       60

gatattgaga aaaaagagat tatagattta ggcagtcgga tttttccatc tggaaatgct      120

gctggaaatc aagacagacg gagttttcgt gggacgcggc gactcatcag acggcgaaaa      180

aatcgtttgt cagatttgac gaagtttttg gctgaaaatg gctttgctgt cagtaatgac      240

aaaaatcaaa atccttatgc ccttcgttcc aaagggctgg cagagcaact atcaaaggaa      300

gaattggcaa ctgcacttta tcatattgtc aatcggcgtg ggatttccta tgatttgggc      360

gatttggaag acgacgggac gagcggtgtt agtgactaca aatcttcgat taatatcaac      420

cgccagcttt tgcgtgaaaa gacgattggg caaattcagc ttgaacggct gaatgaattc      480

ggtcaagttc gtggtcaggt caaagcagat gatgaaacaa ctttgctcaa tgtttttccg      540

tcagctgcct atgcggacga agccaagcag attttggaaa agcaggctga atattatcct      600

gaaatcacgg acgaatttat cgcgaaaatc aatgaactga ttactcgcaa gcgcgaatat      660

tttgtcggtc caggcaatga aaaatcacgt acagattacg ggatttacaa aacggacggt      720

aggacgctgg ataatctttt tgacgaactc atcggaacgg acaaaatcaa cggcgaaaaa      780

cgggcatctg cgtcaagttt gaccgctcag atttataatt tgctcaatga tttgaataac      840

ctgaccgtgc caaacaccga agatggaaaa ttgacgactg aaacgaaaaa agaaattctg      900

tcagctgcga agcgggctga gggtattttt gggaaagttc agatttgtaa gctaattgga      960

gtaaaatttg atgaacttaa aaccaaaaaa ggtggagaaa ttgaatttaa gcatacactt     1020

tttgcttaca gaaaattccg caaagcgctt gcagaaagca atattgaagc aaatgatttg     1080

tccaccgaat ttttcgataa aatcgcagat attctcacgt taaatactga aaaagctgaa     1140

atccgcaagc agttggataa agccgatttt gccatttctg acgaggtaaa agaactcatt     1200

gtcaaagaaa ataaaaatct cctcgttgac ggacgtgcga cttggcacag tttttcttac     1260

aaaaccttga atttgctcat tcctgagctg ctcaatacct ctgatgaaca gatgacgatt     1320

ttgacaggtc tgggcttgat gaagcctgac aatgagaaat atcaaggctt gaagaatatt     1380

ccagcagctc aaatcacaga agaaatttac aatcctgtcg tcgcaaaatc aacgcgcgaa     1440

gccattaatg ttttcaatgc gattgcaaaa cgtgtcggcg cagaaaatat tgcgcacgtt     1500

gtcattgaat tgccgcgcga agacaatgaa gacgatgtta aaaagcaaaa aataaagttt     1560

cagaaagcac aagaagccga gaaaaatgca gctgacgaac tcgtcaaaca acaaatgaca     1620

attcctgaca gcagcttact tgctcaatat cgcaagttca aaggtctatc acaaaaagtg     1680

cgttattggt atcagcaaga aactttttgt ccatactgcg gcgagaaaat caaggtgatt     1740

cagctcatca acaataatga aagttttgaa attgaccaca tcatcccgat ttcagtcagt     1800

tttgatgact cgcaaaataa taaagtgctt gtccatagtc agtgcaatca agcgaaggaa     1860

aagcaaacgc cgcttggctg gattaacaac ggcggcggat ttgggcaaac gaaagcggaa     1920

tacattgcca gagttaaggc aaataaaaat ttcaacaaaa ataaagttga caatctgctc     1980

aacgacgcgg atttgaacga cattatcacg cgtcgtagtt ttattcagcg aaatcttaat     2040

gacacgcgct atgcctcacg cgtggtgctg gacgagtttt acagcttttt caagtcaaac     2100

catctgccca caaaagtcaa ggtcgtccgt ggcaaatgga cttcacaaat gcgtaaaaaa     2160

tggaatagcg caggtggact tgccaaaacg cgcgacacgc atcatcatca cgcgattgat     2220

gccagcatta tcgccagttt tccattgctg aaagcctttg acaaagcggt caaattgatt     2280

gatattgaca aggaaacggg cgaaattttg caagataaag cagcggtcaa aaaagcgcgt     2340

gaagccgaat tattggcgca atgggcgatt ccgaatgaaa aagaatttga aaaattagac     2400

agcgagattt ttgattttcc gcttttcaag caagttgaat tggcaaatga cattgatgac     2460

ccagaaaatc cagtcaaatt cagccacaaa gtcgataaaa aagccaatcg cgccgttgcc     2520

aatcagacga tttacggcac gcgcatgaaa gaaacagaag ttgtaaaacg tggaaaaacg     2580

gaaattgtgc aagatgaata tatctttggc acgataaaaa acatctataa cgtagatgat     2640

tttgcgaaat tcaaaaagtt gtacgatgag gcgctcaaaa aagaggatgt caagtttttg     2700

atgcaagaaa aagacccaaa aacttgggaa aaattgctta aaattctgaa aaacacgcct     2760

gattttgaag aaaaaacgca gacagatgga aaagtcaaag tcatccctgt ttctccattt     2820

gagctttatc gccgtgaaaa tggttttatt actaaatatg ccaagcataa taatgggcca     2880

aaagtggtga gcttgaaata ttacgactca aaaatcggca gtcatattga tattacgcct     2940

gagaacgcta gaaataaagt cgtgttgcaa agcttgaagc cttggcggac ggacgtttac     3000

tacaatcctg acacgcagca atatgaactt ctcggtctca aatatgcaga tttgaaattc     3060

acaaaaggag tttacggaat cacggaggaa gcctatgaaa agctgaaaca tgggattgaa     3120

gcggacggca cgattttgtg gaaaccgatt gggcggaaca gcgagtttcg gtttagtttg     3180

tatcgaaatg atcgtgtgaa gattgtggac gataaagggg aagaaattga gttgttgttt     3240

gggtctcgtg ctggaaacaa tgagggttat gttgagatga aacctatcca caaagcgaga     3300

tttgaaggtg cagaggagat tgctttttat ggaaaaacat cttctggtag atttctaaag     3360

ccattagcta aaaagggcta taaactctac aaagtcaaca cgggaattct aggcacaccc     3420

tactacaccg aaaaagaatc agatcaacca aaattaaatt ta                        3462


<210>  15
<211>  3321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 Original ORF

<400>  15
atggccgatt atcatacaac ctggggattt gacctcggaa ccaattcgct cggctgggcg       60

gttatcgaaa cacgcggcga gccgggccag ggcaacgaag gtcgtatcgt tgacagcggc      120

gtgcggattt tctcgcaggc tgaaatggcg gggcgcgatc cgcagtcgaa agcctcactg      180

gccgttgcca ggcgcgaggc gcgcggtgcg cggcgacgcc gcgatcgcta cctgaaacgc      240

cggcggcggc tgctcgatct cctgacacaa tacggcttga tgccggttga cggcgaagcg      300

cgcgaaaagc tcgtgcgcga tcatgaggac cgcaagggcg gcgacttgtc ggaatcggtt      360

tatgccctgc gtgcccgggc gctcgacaca gcgctcacgc cgcacgagat cggacgtgcg      420

atatttcacc tcaaccagcg ccgtggcttc aaatccaatc gaaagaccga ccgcaacgat      480

cccgaacaag gcaagatcgc gaccgccatc aatgccctgg aagcacagat gattgagaac      540

gaagcgcgga ctttcggtga gtggctgcat atgcgtcgtg aacagggtct gtcggtgcgc      600

gcgcgcatga ctgccgatgg taagggttac gacttctatc cttcgcgtgc ggcgcttgag      660

cgcgagttcg acaggatcat gcagacccag aagcgcttcc acccgaaact gctgggcgac      720

ggcgttatcg ccgacatccg cgaagccgtt tttttccagc gcccgctgaa gccggttctg      780

gcgggcaaat gctcttacaa tacgaaggaa acccggctgc ccaaggcgca tcccttattc      840

cagaaattta ggctgctaaa agaagtcaac gaactggaaa tcgtcggcga ggaccagcag      900

catattaagt tgaggccgga tcagcgtgac gcgctggtgc tagcactgcg caccgacctc      960

aataaacaag gcaagatacc gttctccaag ctgaagaagc aactcggcct tggcaaggaa     1020

gcgcgcttta acaaggagac cgacaaccgc tccgacttgg aaggcgacgt catctatttc     1080

cgcatgtcgc gcccggagtg cttcggcaat cgctgggcgg acataacggt ggaagaccag     1140

gccgcgatca ccgacaagtt gcgcacggaa gcggactaca aggaactcgt tcgctggctg     1200

caactggaag ccgggctgga cgagacacag gccaaggcgg tggttggcat gccggtgcca     1260

gatggcttcg gccgccttgg gcctacggcg ttggcggcgc ttatcgacgc aatggagaac     1320

gacaccgacg agaacggcca cgtcatcacc gaggctgctg ccgcgaaaaa aatctatggc     1380

cgcaccaact ccgaggcgga tcccaaccgc aggggcactg cctatctgcc gaaataccag     1440

gaggtgctgg aacgccacat tccgccggga accggcgagg ccgacgatcc ttacgacgag     1500

cgcatgggcc gcattaccaa tccgaccgtg catatcgcgc tcaaccagtt gcgacgcatc     1560

gtcaatgcgc tgatcgccaa gcatggcaag ccggaccgca tcgccatcga ggtcggccgc     1620

gagctgaagc tgaatgacag gcagcgcgag gcggtcaaca agcgcatcgg gaaaaacacg     1680

aaggaagcac ggcggcgttc tgctgaactg accgataccc acaaggcggc tgataccggt     1740

tacaaccgac tgcggctgaa gctgtgggag gagatcaatg ccgaccagcc gctcaaccgt     1800

ccttgcgtct attgcggcaa accgttgtcg gcggccatgg tgttgagcgc cgagaccgac     1860

atcgatcata tcctgcccta ttcgaagacg ctggacgaca gtcaggcgaa caaggtgctg     1920

tgctgcaccg cctgcaaccg cgaaaagaag aaccgcgccc cggccgacgt gccgcaatgg     1980

cgcgggcgct atccagatat tctcgcccgc gcaaccacgt tgccgaaaaa caagcagtgg     2040

cgttttgccg aggatgccat ggaccgtttc ggcgcggagg aagggttcct cgcccggcaa     2100

ctgaccgata tgcagtatat ctcgcgcttg gcgctgacct atctcgctca cctctatgac     2160

tacgaggagc cggacctcga tggggtcttc agacgccatg cccgtgtgcg cgcgctgcct     2220

ggacgcatga cggagatgct gcgccggtat tggagcctca acgagctgct cccggaccac     2280

aacctcgtcg atattgactt gaccaggcat aagaaccgtc tcgaccaccg tcaccacgcc     2340

atcgacgcca tcgtcatcgc ctgcacctcg cgggcgttga tccagaagct ggcgacggct     2400

gctgctcagg cggaagagaa aggcgcggaa cgggtcgtgg agaagatcgc gccgccgtgg     2460

gagagttttc gagaggatgt gcgcgcagcc gtcaatgaca tcacggtcag ccacaagccg     2520

gatcatggca cggtcagccg cgccggttac gccaatggac gcgggcagac cgccggcaag     2580

ctgcacaatg atactgccta cggcctgacc ggcgaaaagg acgggaaagg caacgatctc     2640

gtcgtgcgcc gtattctgat caccgacatc aggaagccgg ctgacatcat gaagatccgc     2700

gccaacgaac atggacatag cgaacttcgc gaccggttgt ggcaagccac gcgcggcttg     2760

gaaggcaaag ccttcgagga ggccgtactg gactttgtaa acaacgactc gaagttcaag     2820

ggcatccgcc atgtgcggat cgccgaagtc gaaagccctg tgtggatcga gcatggcccg     2880

ggcggggaac accgcaaagg ctatctaccc ggcggcaacg accgctacga ggtctgggaa     2940

atgcccgacg gccgatggca agccgaagtc gtgacgacat tcgatgctca tcgaccggac     3000

ttcgttccgc ggatgcgaca ggcgcatcac aatgcccgca agatcatgag cctgaaaaag     3060

ggcgacatgg tcgcctacaa cgaccccgat agtgggaggc gcatcatcgc aatcgtccgc     3120

aagttcgatc agcgcaacaa gcagctttat ctcgatccgc acaatgaagc aggtgaactc     3180

gacaagcgtg aaagggagaa gacgtacaaa ccgctccgac ccatgccgaa cccgctgaag     3240

aaataccggc cgcgccaggt ccgtatcgac gagattggtc aggtgttcga ccctggcccc     3300

tggtgggaga accgcggcgg t                                               3321


<210>  16
<211>  3159
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 Original ORF

<400>  16
atgaacggcc tcgttttcgg catcgatcta ggcattgcgt cttgcggttg ggccgttctg       60

cgccacccta cccccggcga tccctcaggc aaaatcgtcg ccataggatc atggatgttc      120

gacgttcccg agaccgacaa ggaacggacg cccaccaatc agataaggcg cggcaatcgc      180

ctgctgcgcc gggtcatccg ccgccgcgcg caacgcatgg cagaaatccg ccgcctgttt      240

gcgcagcacg gattgctggg gggccacgaa ccggatgcgc tgaagcgcgc cggacttgat      300

ccgtgggagc tgcgcgcgcg aggactggac aaaccactct cccccgccga attcgccgtt      360

gccttgggcc acattgccaa gcggcgcggg ttcaagtcgg ccagaaagag caaggaggcg      420

aacaccaccg gcgacgacca gaagatgctc aaggcgctgg aggcgaccaa agagcggctc      480

ggccgctatc gaaccgttgg cgagatgttt ggccgcgatg ccgagttccg tgaccgcaag      540

cgcaatcgcg atggtctttt cgaccgcacc cagagccggg acgatctaat ccacgaagtt      600

gcgaagctgt ttgaggcgca acgtcgcttg ggcaatggcg ctgcatcagc cgagcttgaa      660

gctgacttca ccagcatcgc cttccgtcag ctggaaatgc aggacagcga aaagctggtt      720

ggcatgtgcc agttcgagcc caaggaaaag cgcgccgcca agtttgcccc gtctttcgaa      780

aagttccgcc tgctcggcaa actggtgaac ctgcggatta ccgcgccgga gggcgagcgc      840

ccgctcacgc ccgaggaaat cagactggcg acgggcgatc tcggaaaaac ggccaagctc      900

tcagtcaagg aggtgcggaa acggatcggc ctaccagcgg atcagcgctt caccgtgttc      960

aaaccagagg aagagacgca ggacatcgcc gctcgcacag gcgaagcgat gcacggcacc     1020

aagaagctgc gtgatgcact tggggaggtg ctgtcggcgg gcttgcaaac gcgcccggcg     1080

cagctcgacc agatcgcgca tgtcatcagc tttcacgaaa ctgccgacaa gatcggcgag     1140

gagttggcca agctcggcct tccgggcgga gcggtggact cgttaattga caatctgaag     1200

gggttctcgc ggttcaaggg agctggccat atctctgcaa aggcggcgcg cgcgctgatc     1260

ccgcacctcg aagcagggct gcgttacgat caggcgtgcg aggctgctgg ctatgaccat     1320

gcagcgtccc gctggagcaa gcgcgagcag gtggcggaca aggctgggtt caatgcgctg     1380

gtgcaatcga tgggcgacga aatcgccaat cccgtcgcgc ggaaatccct caccgaaggg     1440

ctgaagcacc tttgggcgat gcgcaatcgc tggggtttgc cagatgccgt gcacatcgag     1500

atggcgcgcg atgtcggcaa cagcctcgaa aagcgcaacg agatcaagcg cggcatcgac     1560

aagaatacgg cagagcgcga acgtcagcgc gatgaggtcc gtgaactgct gggcatcgag     1620

gacgtgaacg gcgatacgtt gctgcgctac cgcctatgga aggaacaggc tggacgctgc     1680

ccctacacgg acaaggcgat tccagcgacc tcgatcattg caaccgacaa cagccatcag     1740

gttgaccata tccttccatg gtcgcggttc ggggatgaca gctactctaa caaggtgctt     1800

tgcacggcgc gggcaaacca ggagaagaaa gggcaaacgc ccttcgaatg gatcatgtct     1860

tcgcaaggcg aagatgcctg gaataccttt ctggcccgga ttgaaggaaa caccgcgttc     1920

cggggcgcaa agaagcgcaa ctatgtcctc aagaacgcga aggaggcgga agaacgcttc     1980

cgcagccgca acctcaacga cacccgatat gcagctcgcc tgctcgccga agcagtgaag     2040

ctgttttacc cggaaggtga ccggcaggaa aagggcggca tccgccgtgt cttcacacga     2100

ccaggcggac tgacctcggc cctacgtcat gcgtggggcg tggagtcgct gaagaaggtt     2160

gccggcaaac gggttgaaga tgctcgccac cacgctctcg atgcgctcgt cgttgctgcg     2220

atcggagagt gggaagtaca gcggctcacc cggtcctacc aagagtggga acaaaaaggc     2280

cttgcccgcc cgctacgcca agttgatccg ccatggggcg atgccgccag cttccggcga     2340

gaggtcaaag aagcatatgg caaagttttt gtcgcgagac cggaacggcg gcgtgcgcgc     2400

ggcgaggggc acgccgcgac cgtccggcag gtaaaggaac gcgatggcgc gcttgtcgtc     2460

tatgaacgga agtcgattac cgacctgtcc gaaaagcgat tgcaggacat caaagatccg     2520

gaacgaaatc agggcgtaat tgaggcgatc cgggaatgga tcgcgaatgg aaagcctacg     2580

gacagtctgc cgcgctcccc tgccggagat gaaatccgca aggttcggct tcggacaaaa     2640

ggaaaacctg ccgtgcaggt caggggcggc acggcagatc gcggcgagat tgtccgggtc     2700

gatgtgtttg cgcggcccaa caagcggggc aaggacgagt tctaccttgt gccgatttac     2760

cctcatcacg tgatgaacaa gcgtgactgg cctacgccgc ctgagagatc tgtcgtcgca     2820

tacaaggatg aggacgaatg gacgcttatc gatgaccgct acaagttcaa gttcagcctc     2880

catccaagaa gctatatcga ggtgacaaag cccacgggtg aattgctggc tggatacttc     2940

cagggactga ataggtcgac cggtgctatc aatctctcga acccgagaga cccccgcttg     3000

ttagccgatg acaatggcaa ttcgatgcaa agcattggcg caaaaacttt gttaaccatg     3060

aaaaagtaca atgtggatcg cttcggcgtt tgttccgaag tgaaatccga ggtccgcaca     3120

tggcatggcg tggtctgcac atctccaatc ccgccagac                            3159


<210>  17
<211>  3606
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 Human Optimized

<400>  17
aagaagtaca agctgggcct cgatgtggga gtgtctagcg tgggagtcgc cgtgatcaaa       60

gaggaaaacg gcaagagcag cgtggaaaag ctgagcgtgc ggattgtgcc tgaggacccc      120

aatttccacg gcaagttcta cagcggcaac accgccagca agaacctgga cagaaccatc      180

aagcggggca tcagaaagaa caaccagcgg ttcaaggcca gacgggacaa gctgtaccag      240

acactgcgcg agaacaacat gttccccacc gacaacctgt tcgacctgcc tgccacagag      300

ctgtatggac tgagagccaa ggccgtgtcc aagaaggtgt ccctggaaga actgggcaga      360

atcttcatcg tgctgaacca gcggagaggc ttcctgagca acagaaagag cgtgtccgag      420

gaagagaaca gcaccgagta caaagagtgt atcgccacac tggaaaaaga gctggccggc      480

agaacaatcg gccagaagct gtactctgag ctggaagaga gcgagagcga cttcgaggtg      540

ctgctgagag agagaaccta ccagagaagc agctacatcg aagagttcga ccggatctgg      600

gacgagcaga aaaagtacta cagcgtgctg acaggcggag ccaacgagga caacaacaaa      660

gagacactgt acgacctgat ccgcaaccgg atcatctact accagcggcc tctgaagtcc      720

cagaagggcc tgatcagcga gtgcagcttc gagaagtatc acaaggccac cgccaagtct      780

agcccctact tcgagctgtt cagaatctgg cagaaagtga acgacctgtc ctggaaaacc      840

cctggcggcg agacattcaa gcctacactg ggacagaagc agaacctgaa agaggccctc      900

tggaacggcg agaatctgaa cgccaagcac aagctgtccg tgaccgagat caagaagctg      960

ctcggctacg gccggaacga gaagatctac ctgaacttca ccgagctgga cggctccaga     1020

acctacacag tgctgaagaa cgctctggaa gaggccggca tcgagaactt ccagcagtac     1080

ctgttcttca acctggatat cagcgacgag aaaggcggcc tgtttgagct gtggcacatc     1140

acctatagcc tgcctaccga gaaagaggtg gtcaacgccc tgaagaatag attcggcttc     1200

agcgagaacc agagcgagat cattgccaag aaagtgggct accccagcaa ctacggcaac     1260

ctgagcaccc gggccattag aaagctgctg ccctacctcg agaaaggact gggctactct     1320

gaagcctgtg acgccgtggg ctacgatcac agcggctaca agacagagat cgagctgaag     1380

cccaacctga agcagctgaa gaagaacgag ctgcggaacc ccgtggtgga acagatcctg     1440

aaccaggtcg tgaacgtggt caacctggtc attgagaagt acggcaagat cgacgagatc     1500

agagtggaac tggccagaga gctgagaaac aacgccaaga ccagaaagaa tatcagccag     1560

gccaactcca agaacaagcg gaacaacgac gtgatccgga agaagctgat cgaggaatac     1620

ggcttcagac tggtcaacgg cagggacgtg aagcggtaca tcctgtggga agagacagcc     1680

cacgagtgcc tgtactgcaa caaccccatc aacggcaccg acatgctgac cggcaatgcc     1740

gatattgaac acgtgctgcc caagagcaga tccttcagca acgccatgaa caactacatc     1800

attgcccacc ggaagtgcaa cagcaacaag ggccagaaaa ccgcctacga cttcatggaa     1860

agcaagggcg aagaggtgct gggccagtac atcgaaaaag tgaatgccct gtacaacgac     1920

ggcaagggct ccatcagcaa gagcaagttc gacaatctgc tgtgcaaagg cgaggacatc     1980

ccctccgatt tcgtggaacg gatgaagaag gacagccagt atatcagcaa agaggttgtg     2040

aagatgctca agaccgtgtg tcccaacgtg tacaccacca ccggccaagt gaccgacttc     2100

ctgagagagg aatggaagct gaaaaacctg ctgcaagagc tgaccttcga caagtacaag     2160

gccatcggcc aggtggaaga aaagaccatc aagaccaaga acggccagac caagaccttc     2220

gagacaatca ccgactggtc caagcgggac gatcatagac atcatgccgt ggatgccctg     2280

atctgcgccc tgaccaacca gaagatcatc ttcaagctca acaacctgaa caagatctat     2340

cagtacgagc gggacgccct gtctcagaaa gagattgagg aatttgaaga gttcctcgag     2400

ggcaagttca gcctcaaaga gttcagcacc cagcaagaga acatcattga gtgcagcatc     2460

cccaacatcc gcagagaggt gcagaagcac ttggaagaga tcttcatcag cttcaagaaa     2520

gagaactcca aggtcctcac caagaacatc aacgccccta agaacgtgga acccaagacc     2580

acctgggtgc caagagccag actgcacgag gataccatca tgggcagagt gaagcggatc     2640

gccgagaaga agatgaagct gtctgacaaa gtctccatgg aagaaatcga gatggtcgtc     2700

aaccccgaaa tcaaagagat cctgtatcag cacctgacca agttcgataa caaccctaag     2760

atcgccttcg ctcagaaaac cctgaagggc gagctgatct cctacaaggg caatgagatc     2820

aaagaggtcg gagtctacga gtgggtcaac accaagagag tgaacgtcga gaatttcctg     2880

accgacaatc agaaaacaac ctccgccaag gacaagttca tcgaaaacat cctgaagtcc     2940

gacagaggca tcggcgtgct gctggatcgg cggcttaaag agtttaacgg cgactacaaa     3000

gaggccttca agaacctctc cgagaatccc atcatcacga agaacgggat gatcgtgaag     3060

aacgtgacca tctacgacga gagcaaggtg gaaagagtgc ggaacggcta cgccaaaacc     3120

ggcggaaatc accacgctct gatctacaag gataagaacg gcaagtacaa cgataaggtg     3180

gtgtcctttt gggaagccgt cgagatcggc ctgctgaata tcgccgtgca ccacaatcct     3240

tatcctatca tcaaccggaa cgacaacgaa gagtttggca ccttccagtt cagcatgcag     3300

atcaacgatc tgttcgtgtt cgatctgaag cacagcgaca atccccaaga agagaacgag     3360

attgacttct tcgacgtgaa aaaccggaag ctcatctcca acaatctgtt ccgcgtgcag     3420

aagatgacca agaaaagcag cggcgccttc gaagtgacct acagacacca tctggaagcc     3480

aatctgaatc ggagcgacaa gatcctcaag ggctacacct gggatgagca cggctccaac     3540

aagcacctgg aaaggctgac caagatcaga atcaatcacc tcggggagat catcaagatc     3600

ggcgag                                                                3606


<210>  18
<211>  3066
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 Human Optimized

<400>  18
acactggaag agttccggtc caaggacaga gtgatctggg ccggactgga tatcggagtg       60

gcctctacag gactgtgtct ggtggatgtg cggaaccacg agatcgtgct gatggccagc      120

cacctgttta agagccccgt ggtggataag aagaaggcca cagctgctcc agagtctctg      180

gcttccgtta gaagaggcgc cagaagcgtg cggcggaaca tcatgagaga gggccgcaga      240

aagaaagcca tcagagccgc tctggccgac ttcgatctga tccctgctga taccgatggc      300

gagtggttta gcgccagacg ggatgagaga acagtcgtgc ggctgagatc taaggccctg      360

ggctacctgc tgaacagcag agaactggcc agagtgctgt actcctttgc cagccacaga      420

ggctacatcg accacggcaa gagcgacaaa gaggacgacg ccggcaaagt gaaaaaagcc      480

ctggccgcca atcacgctgc tttggccgat ggcggctgta aaacctttgg ccagtatctg      540

gccggacagc ccagaagcag aaacagagcc ggcgattaca gctacaccgc cgacatcggc      600

atgaccgtgg atgaagtgcg gaccatcttc accagacaga gagagctggg cagcgagatc      660

gccagcaaag ctctggaaga gagatatatc gccgagctga cctggctgac cgacaccagc      720

aaaagagaca gatccaccta cctgaaagtg ggcttctgta cctacctggg cgctccttat      780

agaaggggag ccaccagcac catcagcttc gaaatggttc gagcccatca gaccctgtgc      840

aacacagtga ttctgcacgc cgatggcacc agcagcacaa tccctggcga catcagaatc      900

gagattgtgc gcgagctgtt cgacgtgaag agaagcgtga agcctctgaa gtggtccgga      960

ctgcgaagaa ggctgggact cgccgagtgc gatagcttta aaggcagacc cgccgaggaa     1020

gagaagaggg attgcattgc tctgcctgcc tgggccgttc tgtgtagcgg actgtacgag     1080

aaccaccggg acctgctgga aagactgcac gaccacattg acgatgccga tgccgtgtgt     1140

agcgccctga catttgcttc tagcgctgct tctctggccg gcagacttgc tcctctggct     1200

ctgacagatg acgaggtgga agccatcatc gacctgcctt actccgccag actgttcagc     1260

ggctatgcca atgcctctcc tgaggcactg cagatgctgc ggggcacatt cgaagatcct     1320

agagtgacaa gcctgcggca ggccgaagaa gattctggac tggctcaggc tagagccatg     1380

ctggctgaag aaagaggcgg atctgctgac ggcctgctgt gcgcctttag cgactacgac     1440

cctacctgca gaaaccctgt ggtgctgaga gctacagccc aagtgcggag aatggtcaac     1500

agcgtgatca gacactacgg cctgcctgat gtgatcagag tggaagtggc ccgcgacctg     1560

aagagatcca agcacgaaag ggaaatcgtg gccgagagca acagagccag gctggaactg     1620

aatgagcagg ccaagcggga catcatcgag tttctgggcc tgccagacga ccaccatgtt     1680

cggggaagag atctggccct ggtcaagctg tatagagagc aaggcggcaa ggacccttac     1740

acaggcgccg gaatcgactt cagacggatg ctggaagaac acggctacgc cgagatcgac     1800

cacatcctgc ctgtgtccag aacctgtgac gacagccagg ccaacaaggt gctgtgcctg     1860

accaagtcca accgggacaa gagcaataga agcccctacg agtggatgac ctctggcgaa     1920

gcttctgccc ctgattgggg cgagttctgc ggcagaatgg aaagatgggc caagatgtgc     1980

gagacaagaa gatacgcccg gaagaagctg gccaacctga catgcgagaa tctggccgag     2040

cgggccgaca acttcatcga cagaaacctg aacgacaccc ggtacatgag cgtggccctg     2100

gccaaatggc tgagagagtg cctgcctttc accaaggatg gccacgagca tgtgttctgt     2160

gtggcaggcg gagccacagc tctgatgaga tctgtgtgga atatcggcat cacaggcccc     2220

gacggcaaga agaatagaga ggacgataga caccacgccg tggatgccgc cgtgattgct     2280

tgttgtacac ctggcattgt gcgcaacgtg gccctcgtga atgaaggaca tgctagagcc     2340

gatgtgcggc agaggctgtt tagcgacagt ctgccctatc ctgagttcaa agaacaggtg     2400

gacgcctgga ttccctgcat cgtgcctaca ctgaccctgc ctaataccgt gacaggcagc     2460

gtgctgaagg acacagtgta cccttacctg ggcagagatg aggccggcaa ggatctgtac     2520

atcacagtga agagagacaa ggacggccgg atcgtggaac ggaaagtgaa caaggccacc     2580

acaatgtgga aggacggaca aggcggatgt agagcctatg gcagcatgtg tgccctggaa     2640

gccgtgtttg atgccagcgc cggaaaacgc ggcagatggt cctttgatcc cgtgtactgc     2700

atcgacatcc ctcacaggga tgccgagaga agaaccatgc gggccttcag caaagagaag     2760

gccatcgatc tgtgggacac cgtggcagtg cctgaagccg ctcctcggat gacaattaga     2820

cggggagatg tgctcgtgtg tgacggcaaa gccgccagat tccactgctt cgatatcagc     2880

gtgaacgcca tccggctgtt ttcccagaga ggtggaaagc agctgcaggc cacaggacca     2940

ctgtctgccg aagctttccc acctccatct aagtggggag aaggcgtgcg gatcatgcaa     3000

gaggattgcc tgggactgtg ctggctgtcc tttctggctc agagagcagt ggacgcccag     3060

atggaa                                                                3066


<210>  19
<211>  3429
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 Human Optimized

<400>  19
cactacatcc tgggcctcga tgtgggcatc cagtctgttg gatgggccgt gatcagatac       60

gacgagcccg ccagaatcga ggatttcggc gtgcggatct tcgacaccac cgagaaccag      120

aagtccaagg acaacaccaa tcaagagcgg agagccttca gagccgccag aagagtgctg      180

cggagaagat ctcatcggag agccatggtc aagcggcatc tgcagagaat cggactgctg      240

agagaaggcg aggtggaagc cttttttgag agcggccaga gcgaccctct gagactgaga      300

gtgaagggac tgacagagca gctgacacca gccgaactgg ccgcctgtct gatccacatc      360

agcaaccaca gaggctacca ggccttctac aacctgaccg aggaagaact gaaagagctg      420

cctgccgccg agcggaaaga gtaccagcaa gagagatctg gcatcgagct ggtggaaggc      480

atcatggaac agggccacta tagaagcgtg gccgagatgc tgctgaccga cgacacattt      540

gcccctgatc acgccggacc tatgcgggtg tacagatctc acccctacct ggacacaaga      600

taccccatca gccgggacct gctgagaaaa gaagccgacg ccatcctgac caaccaggcc      660

agattctacc cttgcctgaa cgccccttac cagaccacct ggcggaaaga aagcaagaca      720

accaccaacc gggcctttct ggaatggctg atcttcaccc agcgggactt tgaggatggc      780

cctggcgata gagatgacgc catgcggaag tacacaggct ttctgcaggc cctgggcaag      840

tgccccttct acagagagga agatagaggc cccagaatga ccgtgctggg cgatctgtac      900

gccctgacaa atagcctgag ccagtaccag tacatgaaca ccgagacagg cgtgttcgag      960

ctgcccaaag aactggctga agccatgctg gccgctgctc tgagagatgc cgaactgcct     1020

gccaagaaga tccaagagct ggccaagaga taccacatca aggtggacaa caaggccgtg     1080

aaaaccgccg acagagcccc taactgcatc aagtttctgc ggagagtgcg ccccatcctc     1140

gagaagtacg gcatcaattg ggagacagcc ctcggcggaa ccacactgga agatgtgctg     1200

gccgatgata ccatgctgaa ccagatcggc cgggtgctga gcctgtatca gacccctcat     1260

agacggcaag aggaactggt caagatcccc ggaattagcc ctgaactggc caaaagactg     1320

accgccgaga gaatcagcgg caccgccaaa gtgtctgccc actatatgag ggacgccgtc     1380

gaggcttttc agaagggcga gagatacggc gagttccagt ggcggagaat gaacgagctg     1440

gaacagcctc tgcctggaca ggcttctggc gctcatgtga agctgcctcc atttcctgtg     1500

gacgccgagt tcgccaagaa cagcgtggtc atgagaagcc tgaacgagac acggaagatc     1560

atcaacgcca tcgtgggcca gtatggaagc ccctgggctg tgaatgtgga agtggcctct     1620

gatctgggca gatcttgggc cgagagagcc gagctggaca gaagaaacaa gcagaacgaa     1680

gcccagaccg agaaggacaa gcagcagatc tgtcagatca tgggctacga cagccccgac     1740

caagtgaagg gcagcatggt ggaaagattc cagctggccc agcagcagaa ctggcagtgt     1800

ctgtataccg gcagacccat caccgacaag agagccgctc tggaccctaa gaacaagggc     1860

ttcgaggtgg accacatcgt gcccttcagc atgatcctgg acaataccct gcagaacaag     1920

gccctggtgt acgccgatgc caatcagacc aagggccaga gaacccctct gatgtacctg     1980

agagatcccg ctcagagaga gcagttcatc ggcagagtga atcagatggc caagaaccac     2040

atcatcagcg accggaagag acagtacctg ctgctcgccg acctgtacca caccgatctg     2100

ctggatgagt ggaagtcccg gaacctgaac gacacccggt atatcgccaa gtacctgcgg     2160

ggctacctgg aaagagaact ggccccagct cctgagcaca gaaccccttt cgtgtttcct     2220

gtgaaaggcg gcctgaccag ccggttcaga aggacctggc tgaatagaag cacctgggga     2280

ggcgacgaga agtccgagct gagagagtct acaaccctgc accatgccgt ggatgccgtc     2340

gtgatcgcca atatctctcc tgccacagct cagatcgccg aggacaacct gaggctgaac     2400

agaatcctga agaacagcag aggcatcgag aggcccgagt atagagcaca gctggaaaga     2460

agcctgcaga ccctggaaca gttctaccac gtgccaagaa ctagaggcga ggcctgcctg     2520

aagcggcaga atagaattac agccctgatt gccaacctga acatcgaggt cgacatcaga     2580

tttggcgtgc ccggccagac cacagatccc gattcttata gaagcctggt caccaacttc     2640

tacgccgacg atcctgattt cgccgccaga ctgacacagc ccctgacctc tagaaagccc     2700

gagagaaagc tgcagggcac cctgacaaca gccaacgctc tgggcaccaa agaaatcgat     2760

ggcgtgctgt acgaggccaa gcggaccgat gttatgaagc tgacccagaa gaacctgtct     2820

cagctgtgca ccaacgacgg cgacctcaga gattctctgg ctgagcttct ggccgacgcc     2880

ggaacaagaa cactggctga tgttctgagc gagcagggca agaccgagtt cagaacacag     2940

aagggacagc tgatccggaa agtgaccctg aagggctccg tggtggatca gtacaagatc     3000

aagcagatcg ctcccaacaa ctacagcgtg ctggacacca ccagctacta ctgcacagag     3060

gtgtacaggg accctgccgg aaaaaccaga gtgcgggcca ttgccagagc cagcctcgtg     3120

tgtaaaggca agaagctgtg gctgacctgt cctaatcctg ccgactacgc cgagcacatc     3180

atgtacctgt tcaagaacga ctacatccgg gtcgagacac ccaacggcct gcagttcgag     3240

ggcttttatc agagccctgc cggcatcaag caggccaagt tcaatggcat caagaacaac     3300

gacgccaagt cttgcccctt ccacatctct ggcggagccg tggttaagaa gtacgatatc     3360

tctatcctgg gcagaaaagg cggcgagatc ccttgtggcg aacctctgtc tctgctcctg     3420

gaaaagaag                                                             3429


<210>  20
<211>  3459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 Human Optimized

<400>  20
gtggtcaaca tggaaggcgt gtccatcatg cactacgtgc tgggcctcga tatcggcatc       60

cagtctgttg gatgggccgt gatcagatac gacgagcccg ccagaatcga ggatttcggc      120

gtgcggatct tcgacaccac cgagaacaga aagagcaagg acaacgccaa tcaagagcgg      180

agagccttca gagccgccag aagagtcgtc agaaggcgga gccatcggag agagatgctg      240

aagaaacatc tgcagcggat cggcctgctg agagaaggcg aggtggaagc ctttttcgag      300

agcggcaaga gcgaccctct gagactgaga gtgaagggcc tgacagagca gctgacacct      360

gtggaactgg ccgcctgtct gatccacatc agcaaccaca gaggctacca ggccttctac      420

aacctgaccg aggaagaact gaacgagctg cccgccagcg agaagaaaga gtaccagcaa      480

gagagaagcg gcatcgagca agtgaccggc ctgatggaac agggcaatta cagatccgtg      540

gccgagatgc tgctgaccga tgctgccttt gcttctgagg atggcggccc tatgcggacc      600

tacagatctc acccctacaa ggacacaaga taccccatca gccgggacct gctgaggaaa      660

gaagccgacg ccattctgat gaatcaggcc cagttctacc cctgcctgaa cgaggcctac      720

caagtgacct ggcggaaaga gagcagaacc cctagcaacc gcgagttcct ggaatggctg      780

atgttcgagc agcgggattt cgaggatggc cctggcgata gagatgacgc catgcggaag      840

tacacaggct ttctgcaggc cctgggcaag tgcagcttct acagacaaga ggacagaggc      900

cccagaatgt ctgtgctggg cgatctgtac gccctgacca atagcctgag ccagtaccag      960

tacatcgacg agaaaaccag cgccttcggc atgcccaaga cactggccaa tgatctgctg     1020

gaagccgctc tgcatgatgc cgaactgcct gccaagagaa tccaagagct ggccagaaag     1080

cacagcgtga agatcgacaa caaggccgtg aaaaccgccg acagagcccc taactgcatc     1140

aagttcatgc ggcggatcag acctatcctc gagaagtacg gcatcgactg ggaacaagcc     1200

cttggaggcg ctacactgga agaggccctg gacgacaaca ccatgctgaa cagaatcggc     1260

cgggtgctga gcctgtatca gaccctgcac agacggaaag aggaactggt caagatcccc     1320

ggcattagcc ctgagctggc ctctagactg acagccgaga gaatcagcgg caccgccaaa     1380

gtgtctgccc actacatgag agatgccgtc gaggcctttc agctgggcga gagatatggc     1440

gagttccagt ggcggaggat gaacgagcaa gaacagcctc tgcctggaca ggcctctggc     1500

gccaatttca aactgccagc ctttcctgcc agcgccgagt tcgccaagaa tagcgtggtc     1560

atgcggagcc tgaatgagac acggaaagtg atcaacgccg tgatcgagag atacggcagc     1620

ccctgggctg tgaatgtgga agtggcttct gagctgggaa gatcctgggc cgaaagagat     1680

gagctggacc ggcggaacaa gcagaatctg gcccagaccg agaaggacaa gaagcagatt     1740

tgcgagatca tgggctatca cagccccgac caagtgaacg gctccatgct ggaaagattc     1800

agactggccc agcagcagaa ctggcagtgt ctgtataccg gcaagcccat caccgataag     1860

caggccgctc tggacagcaa gaatcggagc tatgaggtgg accacatcgt gcccttcagc     1920

ctgatcctgg acaataccct gcagaacaag gccctcgtgt gcgccgatgc caatcagaca     1980

aaaggccagc ggacccctct gatgtacctg agagatccac agcagagaga gctgttcatc     2040

ggcagagtga accagatggc caagaaccac gtgatcagcg accggaagag acagtacctg     2100

ctcctggaac acctgggcaa ctctgagctg ctggacgagt ggaaaacccg gaacctgaac     2160

gacacccggt atatcgccaa gtacctgcgg ggctacctcg agagagaact ggctcctgcc     2220

gccgagcaca gaaccccatt tgttttccct gtgaaaggcg gcctgaccag ccggtttaga     2280

agagtgtggc tggacagaga gacatgggga ggcgacgaaa agggacagct gagagagaca     2340

acaaccctgc atcacgccgt ggatgccgtg gttatcgcca acattacacc cgccacagct     2400

ctgatcgccg aggacaacct gcggctgaat agaatcctga agtcctctca cggcgtggaa     2460

acagccgagt attgtgccca gcttgagaga agcctgcaga ccctggaaca gtactatcac     2520

atccccagag ctaaggccca ggcctacctg aagcggaaga ataggatcac cgctctgatc     2580

cccacactga acatcgaagt gaacatccgc ttcggctctc ccggcgagga aatcgaccct     2640

gatacctaca gagcctgcgt gctgtaccac taccacgacg atcctgcttt tgccgccgga     2700

ctgacccctc catgtaccag cagaaaaccc gagagaaagg tgcaaggcgg actgacaaca     2760

gccaacgctc tgggcaccat ggaaatcgat ggggtgctgt atgaggccaa gcgcgtggac     2820

gttatgaagc tgtcctggaa gaatctgagc cagctgtgca ccaacgacgg cgatctgaga     2880

gattccctga tcgaactgct ggccgagaca ggcgataaga agctcgaaga tatcctgagc     2940

gcccagaaca agaccgagtt ccggacaaga aagggcagac tgatcagaaa agtgaccctg     3000

aagggaaacg tggtggacca gtaccgcgtg aagcagatcg ctcccaacaa ctacagcgtg     3060

ctgaacacca ccagctacta ctgcaccgag gtgtacagag ataccgccgg caagaccaaa     3120

gtgcgggcca ttgctagagc cgacctcgtg cggagagaca agaaactgtg gctgacatgc     3180

cccgctccag ccgattatgc cgaacacatc atgtacctgt tcaagaacga ctacatccag     3240

gtgcagaccc acaacggcgt gctgttcgag ggcttttatc agagcccagc cggcatcaag     3300

caggccaagt tcaatggcat cgagaagaac gccagcggca gcagaccttt cagaatctct     3360

ggaaccgcca ccgtgaccaa atacgacatc agcatcctgg gcaaaaaagg cggcgagatt     3420

ccttgtggcg ctccactgtc tctgctgccc gaaagaaaa                            3459


<210>  21
<211>  3156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 Human Optimized

<400>  21
acttggagac tgggcctcga tgtgggcaca aattctgttg gatgggccgc tctcggactg       60

ggccctacag gacctgaaac actgatcgga accggcgtgc ggatcttcag cgacggcaga      120

aatcctaagg atggcagcag cctggccacc aagagaagag agcctagaag cgccagacgg      180

aaccgggaca gatacctgaa gcggcggagc gagttcatgg aaagactggt ggccttcggc      240

ctgatgccta aggacgagag caagcggaaa gagctggaac atctggaccc ctggattctg      300

agatgcagag ccctggatga acccctgaca gcccacgaaa ttggacgggc cctgttccat      360

ctgcaacagc ggagaggctt caagagcaac agaaaggccg acagaggcga cagcgataag      420

ggcgccattg ccgaggctag agagagaaca ctggacagac tggccaacga gggcgccaga      480

actctgggag aactgtttgg ccgcagaaga atggacgccg ctcagaacaa tgccgtgacc      540

tctaaaggcg ccagacagcc tcaacctgcc gccagagtgt ctccttatca agatggcgcc      600

aagctggcct acgactacta ccctacaaga gagctgatcc agcaagagtt cgacctgatc      660

tgggagagcc aggtgtcatt ccagggcaaa gacaccctga ccgacgacgc cagaaatgcc      720

ctggccgata cactgctgta ccagagaaag ctgaagcccc agcctgtggg caaatgctct      780

ctggacccta cacagaccag agccgaaaga gccctgccta gcatccagcg gctgagaatc      840

taccaggacg ccaaccatct gcacgtgctg gtcacaggcg agcctagcag aagcctgaca      900

ctggaagaac gggacatcgt ggtggataga ctgctgggca gcgctagagt gtcctttagc      960

ggactgagaa aggccctgaa gctgcccgcc gacagcagat tcaatctgga aagcgagaag     1020

cggagcttcc tgctgggaga tgagacagcc gccgagctgg ccaaagaaaa acgctgggga     1080

aaagaatggc ggaagatgct gttcgccgac caagaaagaa tcgtgcggca gctgctggac     1140

gtggaagaag aggaagaact gcggcgctgg ctgaccgatg aatttggact gggagccaca     1200

gaggccaacg ccgtgtctga tgcatctctg cctgaaggac acgccgccat ctgttctgat     1260

gctgctggca gactgctgac agctctgcag ggcgccgtga tcacatacga taaggccgtg     1320

atcgaggccg gcttcctgag ccactctaga ctggatcacc acggcgagat cctggacagg     1380

ctgccttatt atggcaaggt gctgcagaga cacgtggcct ttggaagcgg cgaaccttct     1440

gacaaggccg agaagagata cggcaaggtg gccaatccta cagtgcacgt ggccctgaat     1500

cagatcaggc acgtggtcaa cgacctcgtg cggagaatcg gctctcccga ggaaattgtg     1560

attgagctgg ctcgggatct gcctctgtct gcccagggaa agagagatct ggaaaagcgg     1620

cagcgcgaga accagaacgc caatgagaaa agaagagagg acctgcggaa gctgggcaga     1680

agcgacacct acgagaaccg gatgagactg cggctgtggg aagaactcaa ccccgagaac     1740

gtgctggaca gaaagtgccc ttttaccggc gagcagatcg gcatcgagag actgtttagc     1800

gacgaggtgg aaatcgagca catcctgcct aagagcagaa ccctggacga cagccctgcc     1860

aacaagaccc tgtgcatgag atccgccaac cgggaaaaaa gagagcggag cccttacgag     1920

gcctttggca gctctcctgg ctcttattct tggggccata ttgtggccag agccgccaac     1980

atgcctagca acaagtcttg gagattcgcc cctgacgcca tggacagatt cgagagcgag     2040

gaaagagact tcctggaccg gcagctgagc agcacccagt atattgccag actgaccgcc     2100

aactacctcg tgtggcttgt gggcgatcct ggaaaggtgc acgttacccc aggcagactg     2160

acaagcgatc tgagacacca ctggggcctg aatagcgtgc tgagaggaca caatgaggcc     2220

gagccagagg ccatcggcca gaagaagaac agaaacgacc accggcacca cgccatcgat     2280

gctattgtgg tggctctgac cgatcggggc ctgctgaaga agattgctac acaggccgcc     2340

agaaaccaga gcaattctag cggccagctg atcgacacca tcgatacccc ttgggccagc     2400

ttcagagatg atgtggccgc ctgcctgtcc tccatcatcg tgtctcacaa agccgaccat     2460

ggcgtgcaag gcgctctgca caatgataca gcctacggac tggccagcga cgccgataag     2520

acaggcaaga gagatgtggt ccacagagtg cctgtggcca gcctggatac cctgaaaaag     2580

atcgagcaag tgcgggaccc tctgatcagg gatgccttta tggatgccgc cgctggcctg     2640

acaggcaaag atgtggttac agccgttgtg acagccggcg aagctatgac acctcctgtg     2700

cgaaaagtgc gcgtgctgga aaggatgaac gtgatcccca tcaacgacaa ggacggccag     2760

acctacaagg cttacaaagg cgacggcaac tactgctacg acatctatgc caacgagaaa     2820

ggcggatgga ccggcgaggt cgtgtccaga tttgatgcca accagcctag cttcgaggcc     2880

aatggcagca tctctagaag cggcacccca ctgatcatga gaatcagagg cggcgacacc     2940

ctgctgattg atcaaggaca gggcgagaga ttcatgcggg tcgtgaagtt cagcagcggc     3000

atgatttgcc tggccgagca ctttgaggcc ggaagcctga aggccagaga caccgatcag     3060

cacgacgact tcaagtacct gatcgtggcc cctagcagac tgcagaattg gggagcccag     3120

attgtgcacg tgtccccaag cggacacgtg ttcaga                               3156


<210>  22
<211>  3459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 Human Optimized

<400>  22
acaaagtaca gcgtcggcct ggacatcgga atcgcctctt gtggctggtc catcatcgac       60

atcgagaaga aagagatcat cgacctcggc agcagaatct tcccttctgg caatgccgcc      120

ggaaaccagg acagaagaag cttcagaggc accagacggc tgatccggcg gagaaagaat      180

agactgagcg acctgaccaa gttcctggcc gagaatggct tcgccgtgtc caacgacaag      240

aatcagaacc cctacgctct gcggagcaaa ggactggccg aacagctgtc taaagaggaa      300

ctggccaccg ctctgtacca catcgtgaac agaagaggca tcagctacga cctgggcgac      360

ctggaagatg atggcacaag cggcgtgtcc gactacaaga gcagcatcaa catcaaccgg      420

cagctgctgc gggaaaagac catcggccag attcagctgg aacggctgaa cgagtttggc      480

caagtgcggg gacaagtgaa ggccgacgat gagacaaccc tgctgaatgt gtttcctagc      540

gccgcctatg ccgacgaggc caagcagatt ctggaaaagc aggccgagta ctaccccgag      600

atcaccgacg agtttatcgc caagatcaac gagctgatca cccggaagag agagtacttc      660

gtcggccctg gcaacgagaa gtccagaacc gactacggca tctacaagac cgacggcaga      720

accctggaca acctgttcga tgagctgatc ggcaccgaca agatcaatgg cgagaagaga      780

gccagcgcca gctctctgac agcccagatc tacaatctgc tgaacgacct gaacaacctg      840

accgtgccta acaccgagga tggcaagctg accaccgaga caaagaaaga aatcctgtcc      900

gccgccaaga gagccgaggg catttttggc aaggtgcaaa tctgcaagct catcggcgtg      960

aagttcgacg aactcaagac caagaaaggc ggcgagatcg agttcaagca caccctgttc     1020

gcctaccgga agttcagaaa ggccctggcc gaaagcaaca tcgaggccaa tgatctgagc     1080

accgagttct tcgataagat cgccgacatc ctgacactga acaccgagaa ggccgagatc     1140

cggaagcagc tggataaggc cgatttcgcc atcagcgacg aagtgaaaga actgatcgtg     1200

aaagagaaca agaacctgct ggtggacggc agagccacct ggcacagctt tagctataag     1260

accctgaacc tgctcatccc cgagctgctg aataccagcg acgagcagat gaccattctg     1320

accggcctgg gcctgatgaa gcccgataat gagaagtacc agggcctgaa gaacatccct     1380

gccgctcaga ttaccgaaga gatctataac cccgtggtgg ccaagagcac ccgcgaggcc     1440

atcaacgtgt tcaacgccat tgccaaaaga gtgggcgccg agaatatcgc ccacgtggtc     1500

attgagctgc ccagagagga taacgaggac gacgtgaaga agcagaagat caagttccag     1560

aaggcccaag aggccgaaaa gaacgccgcc gatgaactgg tcaagcagca aatgacaatc     1620

cccgactcta gcctgctggc ccagtacaga aagttcaagg gcctgagcca gaaagtgcgg     1680

tactggtatc agcaagagac attctgcccc tactgcggcg agaaaatcaa agtgatccag     1740

ctgatcaaca acaacgagag cttcgagatc gaccacatca tccccatcag cgtgtccttc     1800

gacgacagcc agaacaacaa ggtgctggtg cacagccagt gcaaccaggc caaagagaag     1860

cagacacccc tcggctggat caacaatggc ggaggctttg gacagaccaa agccgagtat     1920

attgcccgcg tgaaggccaa caagaatttc aacaagaaca aggtcgacaa cctcctgaac     1980

gacgccgacc tgaatgacat catcacccgg cggagcttca tccagcggaa cctgaacgat     2040

accagatacg ccagcagagt ggtgctggac gagttctaca gcttcttcaa gagcaaccat     2100

ctgccgacca aagtgaaggt cgtcagaggc aagtggacaa gccagatgcg gaagaagtgg     2160

aactctgccg gcggactggc caagaccaga gatacacacc accaccacgc catcgacgcc     2220

tctatcattg ccagctttcc actgctgaag gcctttgaca aggccgtgaa gctgatcgac     2280

attgacaaag agacaggcga gattctgcag gacaaagccg ccgtgaagaa agccagagaa     2340

gccgaactgc tggctcagtg ggctatcccc aacgagaaag agttcgagaa gctggacagc     2400

gagatcttcg acttcccact gttcaagcag gtcgagctgg ccaacgacat cgacgaccct     2460

gagaaccctg tgaagttctc ccacaaggtg gacaaaaagg ccaatagagc cgtggccaac     2520

cagaccatct acggcaccag aatgaaggaa accgaggtcg tcaagcgggg caagaccgaa     2580

atcgtgcagg acgagtacat cttcgggacc atcaagaaca tctacaacgt ggacgacttc     2640

gccaagttca agaaactgta cgatgaggcc ctcaagaaag aggacgtcaa gttcctcatg     2700

caagagaagg accccaagac ctgggagaaa ctgctcaaga tcctgaagaa taccccggac     2760

ttcgaggaaa agacacagac agacggcaaa gtgaaagtga ttcccgtgtc acccttcgag     2820

ctgtacagaa gagagaacgg ctttatcacc aaatacgcca agcacaacaa cggccccaag     2880

gtggtgtccc tgaagtacta cgatagcaag atcggcagcc acatcgatat caccccagag     2940

aacgcccgga acaaggtggt cctgcagtct ctgaagcctt ggcggaccga cgtgtactac     3000

aaccccgata cacagcagta tgagctgctg ggactgaagt acgccgatct gaagttcacc     3060

aagggcgtgt acggcatcac cgaggaagcc tacgagaaac tgaagcacgg aatcgaggcc     3120

gacggcacca tcctgtggaa gcctatcggc agaaacagcg agttccggtt ctccctgtac     3180

cggaacgaca gagtgaagat cgtggacgat aagggcgaag agattgaact gctgtttggc     3240

agcagagccg gcaacaatga gggctacgtg gaaatgaagc ccatccacaa ggccagattt     3300

gagggcgctg aggaaatcgc cttctacggc aagaccagca gcggcagatt tctgaagcca     3360

ctggccaaaa agggctacaa gctgtacaaa gtgaacaccg gcatcctggg caccccttac     3420

tacacagaga aagagagcga ccagcctaag ctgaacctg                            3459


<210>  23
<211>  3318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 Human Optimized

<400>  23
gccgattacc acaccacctg gggctttgat ctgggcacaa attctctcgg ctgggccgtg       60

attgagacaa gaggcgaacc tggacagggc aacgagggca gaattgtgga tagcggcgtg      120

cggattttca gccaggcaga gatggctggc agagatcctc agtctaaggc ctctctggcc      180

gtggccagaa gagaagctag aggcgctcgg cggagaagag acagatacct gaagagaaga      240

aggcggctgc tggacctgct gacccagtat ggacttatgc ctgtggacgg cgaggccaga      300

gaaaaactcg tgcgggacca cgaggacaga aaaggcggag atctgagcga gagcgtgtac      360

gctctgagag ctagagccct ggatacagcc ctgacacctc acgagatcgg cagagccatc      420

ttccacctga accagcggag aggcttcaag agcaacagaa agaccgaccg gaacgacccc      480

gagcagggaa agattgccac agccatcaat gccctggaag cccagatgat cgagaacgag      540

gctagaacct ttggcgagtg gctgcacatg agaagagaac agggcctgtc tgtgcgggcc      600

agaatgacag ccgatggcaa gggctacgac ttctaccctt ctcgggctgc cctcgagcgc      660

gagttcgata gaatcatgca gacccagaag cggtttcacc ccaagctgct tggagatggc      720

gtgatcgccg atatccgcga ggccgtgttc tttcagcgac ctctgaaacc tgtgctggcc      780

ggcaagtgca gctacaacac caaagagaca cggctgccca aggctcaccc tctgttccag      840

aagttccggc tgctcaaaga agtgaacgag ctggaaatcg tgggcgaaga tcagcagcac      900

atcaagctga ggcctgacca gagagatgcc ctggttctgg ccctgagaac cgatctgaac      960

aagcagggca agatcccctt cagcaagctg aagaagcagc tcggcctggg caaagaggcc     1020

cggttcaaca aagaaaccga caacagaagc gacctggaag gcgacgtgat ctacttcaga     1080

atgagcagac ccgagtgctt cggcaacaga tgggccgaca tcacagtgga agatcaggcc     1140

gccatcaccg ataagctgag gaccgaggcc gactacaaag aacttgtgcg gtggctgcag     1200

ctggaagccg gacttgatga gacacaggcc aaggccgttg tgggcatgcc tgtgcctgat     1260

ggatttggca gactgggccc tacagctctg gccgctctga tcgacgccat ggaaaacgac     1320

accgacgaga acggccacgt gatcacagaa gccgccgctg ccaagaagat ctacggcaga     1380

acaaacagcg aggccgatcc taacagacgg ggcacagcct acctgcctaa gtaccaagag     1440

gtgctggaac ggcacatccc acctggaaca ggcgaagccg atgatcccta cgacgagcgg     1500

atgggcagaa tcacaaaccc cacagtgcac attgccctga atcagctgcg gagaatcgtg     1560

aacgccctga tcgccaagca cggcaagcct gacagaatcg ccatcgaagt gggcagagag     1620

ctgaagctga acgacagaca gcgggaagcc gtgaacaagc ggatcggcaa gaataccaaa     1680

gaagccagaa ggcggagcgc cgagctgaca gatacacata aggccgccga caccggctac     1740

aaccggctga gactgaaact gtgggaagag atcaacgccg accagcctct gaacagacct     1800

tgcgtgtact gtggcaaacc tctgtctgcc gccatggtgc tgagcgccga aaccgatatc     1860

gaccacatcc tgccttacag caagaccctg gacgacagcc aggccaacaa ggtgctgtgc     1920

tgcaccgcct gcaaccgcga gaaaaagaat agagcccctg ccgacgtgcc acagtggcgg     1980

ggaagatatc ctgatatcct ggccagagcc accacactgc ccaaaaacaa acaatggcgc     2040

ttcgccgagg atgccatgga cagatttggc gccgaagagg gctttctggc tagacagctg     2100

accgacatgc agtacatcag cagactggct ctgacctatc tggcccacct gtacgactac     2160

gaggaacccg atctggatgg cgtgttcaga aggcacgcca gagttagagc actgcccggc     2220

agaatgaccg agatgctgag aagatactgg tccctgaacg aactgctgcc cgaccacaac     2280

ctggtggaca tcgatctgac ccggcacaag aacagactgg accacagaca ccacgccatc     2340

gatgccatcg tgattgcctg taccagcaga gccctgatcc agaagcttgc tacagccgct     2400

gctcaggccg aagagaaagg cgcagaacgc gtggtggaaa agatcgcccc tccatgggag     2460

agcttcagag aagatgtgcg ggctgccgtg aacgacatca ccgtgtctca caagcctgat     2520

cacggcacag tgtctagagc cggctatgcc aatggaagag gccagacagc cggaaagctg     2580

cacaatgata cagcctacgg cctgaccggc gagaaggacg gaaagggcaa tgatctggtc     2640

gtgcgcagaa tcctgatcac cgacatcaga aagcctgccg atatcatgaa gatccgggcc     2700

aatgagcacg gccacagcga actgagagat agactgtggc aggccaccag aggactggaa     2760

ggcaaagcct ttgaagaggc cgtgctggac ttcgtgaaca acgacagcaa gttcaagggc     2820

atcagacacg tgcggatcgc cgaggtggaa tctcctgtgt ggattgaaca cggacctggc     2880

ggcgagcaca gaaagggata tctgccaggc ggcaacgaca gatacgaagt gtgggagatg     2940

cccgatggca gatggcaggc tgaggtcgtg accacctttg acgcccacag acctgacttc     3000

gtgcccagaa tgagacaggc tcaccacaac gcccggaaga tcatgagcct gaagaaaggc     3060

gacatggtgg cctacaacga ccctgactct ggcagacgga ttatcgccat tgtgcggaag     3120

ttcgaccagc gcaacaagca gctgtatctg gaccctcaca atgaggccgg cgagctggat     3180

aagcgcgagc gggaaaaaac ctacaagccc ctgcggccta tgcctaatcc tctgaagaag     3240

tacagaccca ggcaagtgcg catcgatgag atcggccagg tgttcgatcc tggaccttgg     3300

tgggagaata gaggcgga                                                   3318


<210>  24
<211>  3156
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 Human Optimized

<400>  24
aatggcctgg tgttcggcat cgatctggga atcgcttctt gtggctgggc cgtgctgaga       60

catcctacac ctggcgatcc tagcggcaag atcgtggcca tcggcagctg gatgttcgac      120

gtgccagaga cagacaaaga gcggacccct accaaccaga tcagacgggg aaacagactg      180

ctgcggagag tgattcggcg gagagcccag agaatggccg agatcagaag gctgtttgcc      240

cagcatggac tgctcggagg acacgagcct gatgctctga aaagagctgg actggacccc      300

tgggaactga gagccagagg actggataag cctctgagcc ctgccgaatt tgccgtggct      360

ctgggccaca ttgccaagag aagaggcttc aagagcgcca gaaagagcaa agaggccaac      420

accaccggcg acgaccagaa gatgctgaaa gccctggaag ccaccaaaga gagactgggc      480

agatacagaa ccgtgggcga gatgtttggc cgggacgccg agttcaggga cagaaagcga      540

aacagagatg gcctgttcga cagaacccag agcagggacg atctgatcca cgaggtggcc      600

aagctgttcg aggctcagag aaggcttgga aatggcgccg cttctgccga gctggaagcc      660

gatttcacct ctatcgcctt cagacagctg gaaatgcagg acagcgagaa gctcgtgggc      720

atgtgccagt tcgagcccaa agagaaaaga gccgccaagt tcgcccctag cttcgagaag      780

tttcggctgc tgggaaagct ggtcaacctg cggattacag cccctgaggg cgaaagacct      840

ctgacacccg aagagattag actggccaca ggcgatctgg gcaagaccgc caaactgagc      900

gtgaaagaag tgcggaagag aatcggcctg cctgccgatc agagattcac cgtgttcaag      960

cccgaggaag agacacagga tatcgccgcc agaacaggcg aagccatgca cggaacaaag     1020

aagctgaggg acgctctggg agaagtgctg tctgctggac tgcagacaag acccgctcag     1080

ctggaccaga ttgcccacgt gatcagcttc cacgagacag ccgataagat cggcgaggaa     1140

ctggccaaac ttggactgcc tggcggagcc gtggacagcc tgattgataa tctgaagggc     1200

ttcagccggt tcaaaggcgc cggacacatt tctgccaaag ccgccagagc actgatccct     1260

cacctggaag ctggcctgag atatgatcag gcctgtgaag ccgccggata cgatcatgct     1320

gccagcagat ggtccaagcg cgaacaggtt gccgacaagg ccggctttaa tgccctggtg     1380

cagtctatgg gcgacgagat cgctaatccc gtggccagaa agtctctgac cgagggactg     1440

aaacacctgt gggccatgag aaacagatgg ggcctgccag atgccgtgca catcgaaatg     1500

gccagagatg tgggcaactc cctggaaaag cggaacgaga tcaagcgggg catcgacaag     1560

aataccgccg agcgcgaaag acagagggac gaagttcgag agctgctggg catcgaggat     1620

gtgaatggcg acaccctgct gcggtacaga ctgtggaaag aacaggccgg cagatgcccc     1680

tacaccgata aggccattcc agccaccagc atcattgcca ccgacaactc tcaccaggtg     1740

gaccacatcc tgccttggag cagattcggc gacgatagct acagcaacaa ggtgctgtgt     1800

accgccaggg ccaatcaaga gaaaaagggc cagacacctt tcgagtggat catgagcagc     1860

cagggcgaag atgcctggaa caccttcctg gccagaatcg agggcaacac tgccttcaga     1920

ggcgccaaga aacggaacta cgtgctgaag aacgctaaag aggccgagga acggttcaga     1980

agccggaacc tgaacgacac cagatacgcc gctagactgc tggccgaggc cgtgaagctt     2040

ttttacccag agggcgacag acaagagaaa ggcggcatca gaagagtgtt caccagacct     2100

ggcggactga catctgccct gagacatgcc tggggcgtcg agtctctgaa gaaggtggcc     2160

ggaaaacgcg tggaagatgc cagacatcat gctctggatg cactggtggt ggccgccatt     2220

ggagaatggg aagtgcagag actgacccgg tcctaccaag agtgggagca gaaaggactg     2280

gccaggcctc tgagacaagt tgatcctcct tggggagatg ccgccagctt cagaagagaa     2340

gtcaaagaag cctacggcaa ggttttcgtg gctagacctg agcgtcggag agctagaggc     2400

gaaggacatg ccgccaccgt gcggcaagtg aaagaaagag atggcgccct ggtcgtgtac     2460

gagagaaagt ccatcaccga cctgtccgag aagcggctgc aggatatcaa ggaccccgag     2520

agaaatcagg gcgtgatcga ggccatcaga gagtggattg ccaacggcaa gcctaccgac     2580

agcctgccta gatctcctgc cggggacgag attagaaaag tgcggctgag aacaaagggc     2640

aagcccgccg ttcaagttcg cggcggaaca gctgatagag gcgagatcgt cagagtggac     2700

gtgttcgcca ggcctaacaa gagaggcaag gacgagttct acctggtgcc tatctaccct     2760

caccacgtga tgaacaaacg cgactggccc acacctcctg agagaagcgt ggtggcctac     2820

aaggatgagg acgagtggac cctgatcgac gaccggtaca agttcaagtt ttctctgcac     2880

cctcggagct acatcgaagt gaccaagcct acaggcgaac tgctggctgg atactttcag     2940

ggcctgaata gaagcaccgg cgccatcaac ctgagcaacc ccagagatcc taggctgctc     3000

gccgacgaca atggcaactc tatgcagagc atcggcgcta agaccctgct gaccatgaag     3060

aagtacaacg tcgaccgctt cggcgtgtgc agcgaagtga agtctgaagt tcggacatgg     3120

cacggcgtcg tgtgcacaag ccctattcct ccagat                               3156


<210>  25
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 crRNA_v1

<400>  25
guugugaauu gcuuucaaaa uuuauuaucu uc                                     32


<210>  26
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 tracRNA_v1

<400>  26
uuggauuaua aauuuugaaa gcaauucaca au                                     32


<210>  27
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 partial_crRNA_1_15_v1

<400>  27
guugugaauu gcuuu                                                        15


<210>  28
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 partial_antirepeat_1_15_v1

<400>  28
aaagcaauuc acaau                                                        15


<210>  29
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 partial_crRNA_2_15_v1

<400>  29
guugugaauu gc                                                           12


<210>  30
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 partial_antirepeat_2_15_v1

<400>  30
gcaauucaca au                                                           12


<210>  31
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 partial_crRNA_3_15_v1

<400>  31
guugugaauu                                                              10


<210>  32
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 partial_antirepeat_3_15_v1

<400>  32
aauucacaau                                                              10


<210>  33
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 part1_v1

<400>  33
aaggauuauu ccgu                                                         14


<210>  34
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 part1_partial_v1

<400>  34
aaggauuauu cc                                                           12


<210>  35
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 part2_v1

<400>  35
ugugaaaaca uuuaagcc                                                     18


<210>  36
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 part2_partial_v1

<400>  36
ugugaaaaca                                                              10


<210>  37
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 part3_v1

<400>  37
cccucgucuu accauacggg ggauuuuuu                                         29


<210>  38
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 part3_partial_v1

<400>  38
cccucgucuu accauacggg gg                                                22


<210>  39
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 part3_without_polyt_v1

<400>  39
cccucgucuu accauacggg gga                                               23


<210>  40
<211>  129
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 sgRNA_v1

<400>  40
guugugaauu gcuuucaaaa uuuauuaucu ucgaaauugg auuauaaauu uugaaagcaa       60

uucacaauaa ggauuauucc guugugaaaa cauuuaagcc cccucgucuu accauacggg      120

ggauuuuuu                                                              129


<210>  41
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 crRNA_v2

<400>  41
guugugaauu gcuuucauaa uuuauuaucu uc                                     32


<210>  42
<211>  32
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 tracRNA_v2

<400>  42
uuggauuaua aauuaugaaa gcaauucaca au                                     32


<210>  43
<211>  129
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 sgRNA_v2

<400>  43
guugugaauu gcuuucauaa uuuauuaucu ucgaaauugg auuauaaauu augaaagcaa       60

uucacaauaa ggauuauucc guugugaaaa cauuuaagcc cccucgucuu accauacggg      120

ggauuuuuu                                                              129


<210>  44
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 crRNA_v3

<400>  44
guugugaauu gcuuuc                                                       16


<210>  45
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 tracRNA_v3

<400>  45
gaaagcaauu cacaau                                                       16


<210>  46
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-56 sgRNA_v3

<400>  46
guugugaauu gcuuucgaaa gaaagcaauu cacaauaagg auuauuccgu ugugaaaaca       60

uuuaagcccc cucgucuuac cauacggggg auuuuuu                                97


<210>  47
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 crRNA_v1

<400>  47
gcccuagcgc g                                                            11


<210>  48
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 tracRNA_v1

<400>  48
aacguuuggg c                                                            11


<210>  49
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 partial_crRNA_3_15_v1

<400>  49
gcccuagcgc                                                              10


<210>  50
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 partial_antirepeat_3_15_v1

<400>  50
aacguuuggg c                                                            11


<210>  51
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part1_v1

<400>  51
aagagggccc guuaaagacg ggucacucgc                                        30


<210>  52
<211>  28
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part1_partial_v1

<400>  52
aagagggccc guuaaagacg ggucacuc                                          28


<210>  53
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part2_v1

<400>  53
ggaguauauc ccgcagggug cuuuucgcac ucugcgggug aucuccuuuu cccuccuuuu       60

uu                                                                      62


<210>  54
<211>  46
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part2_partial_v1

<400>  54
ggaguauauc ccgcagggug cuuuucgcac ucugcgggug aucucc                      46


<210>  55
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part2_without_polyt_v1

<400>  55
ggaguauauc ccgcagggug cuuuucgcac ucugcgggug aucuccuuuu cccucc           56


<210>  56
<211>  118
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 sgRNA_v1

<400>  56
gcccuagcgc ggaaaaacgu uugggcaaga gggcccguua aagacggguc acucgcggag       60

uauaucccgc agggugcuuu ucgcacucug cgggugaucu ccuuuucccu ccuuuuuu        118


<210>  57
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 crRNA_v2

<400>  57
gcccuagcgc guug                                                         14


<210>  58
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 tracRNA_v2

<400>  58
aguaacguuu gggcaagagg gc                                                22


<210>  59
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 partial_crRNA_2_15_v2

<400>  59
gcccuagcgc gu                                                           12


<210>  60
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 partial_antirepeat_2_15_v2

<400>  60
acguuugggc aagagggc                                                     18


<210>  61
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 partial_antirepeat_3_15_v2

<400>  61
guuugggcaa gagggc                                                       16


<210>  62
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part1_v2

<400>  62
ccguuaaaga cgggucacuc gc                                                22


<210>  63
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part1_partial_v2

<400>  63
ccguuaaaga cgg                                                          13


<210>  64
<211>  124
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 sgRNA_v2

<400>  64
gcccuagcgc guuggaaaag uaacguuugg gcaagagggc ccguuaaaga cgggucacuc       60

gcggaguaua ucccgcaggg ugcuuuucgc acucugcggg ugaucuccuu uucccuccuu      120

uuuu                                                                   124


<210>  65
<211>  62
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part2_v3

<400>  65
ggaguauauc ccgcagggug cuauucgcac ucugcgggug aucuccuauu cccuccuuuu       60

uu                                                                      62


<210>  66
<211>  46
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part2_partial_v3

<400>  66
ggaguauauc ccgcagggug cuauucgcac ucugcgggug aucucc                      46


<210>  67
<211>  56
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 part2_without_polyt_v3

<400>  67
ggaguauauc ccgcagggug cuauucgcac ucugcgggug aucuccuauu cccucc           56


<210>  68
<211>  118
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-58 sgRNA_v3

<400>  68
gcccuagcgc ggaaaaacgu uugggcaaga gggcccguua aagacggguc acucgcggag       60

uauaucccgc agggugcuau ucgcacucug cgggugaucu ccuauucccu ccuuuuuu        118


<210>  69
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 crRNA_v1

<400>  69
guuuugguuc ucuga                                                        15


<210>  70
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 tracRNA_v1

<400>  70
cagaaguucu aagau                                                        15


<210>  71
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_crRNA_2_15_v1

<400>  71
guuuugguuc uc                                                           12


<210>  72
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_antirepeat_2_15_v1

<400>  72
gaaguucuaa gau                                                          13


<210>  73
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_crRNA_3_15_v1

<400>  73
guuuugguuc                                                              10


<210>  74
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_antirepeat_3_15_v1

<400>  74
aguucuaaga u                                                            11


<210>  75
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 part1_v1

<400>  75
aaggcuuuac gcc                                                          13


<210>  76
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 part1_partial_v1

<400>  76
aaggcuuuac gcc                                                          13


<210>  77
<211>  46
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 part2_v1

<400>  77
gcaggguaug gugguauccc aaauauucca ccauuugauu guaucu                      46


<210>  78
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 part2_partial_v1

<400>  78
gcaggguaug gugguauccc aaauauucca ccauuugauu gu                          42


<210>  79
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 part3_v1

<400>  79
gaaagcgucc gguucgggcg cuuuuu                                            26


<210>  80
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 part3_partial_v1

<400>  80
gaaagcgucc gguucgggcg cuuuu                                             25


<210>  81
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 part3_without_polyt_v1

<400>  81
gaaagcgucc gguucgggcg c                                                 21


<210>  82
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 sgRNA_v1

<400>  82
guuuugguuc ucugagaaac agaaguucua agauaaggcu uuacgccgca ggguauggug       60

guaucccaaa uauuccacca uuugauugua ucugaaagcg uccgguucgg gcgcuuuuu       119


<210>  83
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 crRNA_v2

<400>  83
guuuugguuc ucugaugg                                                     18


<210>  84
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 tracRNA_v2

<400>  84
caucagaagu ucuaagau                                                     18


<210>  85
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_crRNA_1_15_v2

<400>  85
guuuugguuc ucuga                                                        15


<210>  86
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_antirepeat_1_15_v2

<400>  86
ucagaaguuc uaagau                                                       16


<210>  87
<211>  125
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 sgRNA_v2

<400>  87
guuuugguuc ucugauggga aacaucagaa guucuaagau aaggcuuuac gccgcagggu       60

auggugguau cccaaauauu ccaccauuug auuguaucug aaagcguccg guucgggcgc      120

uuuuu                                                                  125


<210>  88
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 crRNA_v3

<400>  88
guuuugguuc uucug                                                        15


<210>  89
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_crRNA_2_15_v3

<400>  89
guuuugguuc uu                                                           12


<210>  90
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_antirepeat_2_15_v3

<400>  90
aaguucuaag au                                                           12


<210>  91
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_antirepeat_3_15_v3

<400>  91
guucuaagau                                                              10


<210>  92
<211>  119
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 sgRNA_v3

<400>  92
guuuugguuc uucuggaaac agaaguucua agauaaggcu uuacgccgca ggguauggug       60

guaucccaaa uauuccacca uuugauugua ucugaaagcg uccgguucgg gcgcuuuuu       119


<210>  93
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 crRNA_v4

<400>  93
gucuugguuc ucugaugg                                                     18


<210>  94
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_crRNA_1_15_v4

<400>  94
gucuugguuc ucuga                                                        15


<210>  95
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_crRNA_2_15_v4

<400>  95
gucuugguuc uc                                                           12


<210>  96
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 partial_crRNA_3_15_v4

<400>  96
gucuugguuc                                                              10


<210>  97
<211>  125
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-65 sgRNA_v4

<400>  97
gucuugguuc ucugauggga aacaucagaa guucuaagau aaggcuuuac gccgcagggu       60

auggugguau cccaaauauu ccaccauuug auuguaucug aaagcguccg guucgggcgc      120

uuuuu                                                                  125


<210>  98
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 crRNA_v1

<400>  98
guuuugguuc ucuga                                                        15


<210>  99
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 tracRNA_v1

<400>  99
cagaaguucu aagau                                                        15


<210>  100
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_crRNA_2_15_v1

<400>  100
guuuugguuc uc                                                           12


<210>  101
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_antirepeat_2_15_v1

<400>  101
gaaguucuaa gau                                                          13


<210>  102
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_crRNA_3_15_v1

<400>  102
guuuugguuc                                                              10


<210>  103
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_antirepeat_3_15_v1

<400>  103
aguucuaaga u                                                            11


<210>  104
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 part1_v1

<400>  104
aaggcuuuac gccg                                                         14


<210>  105
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 part1_partial_v1

<400>  105
aaggcuuuac gcc                                                          13


<210>  106
<211>  45
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 part2_v1

<400>  106
caggguaugg ugguaucccg aacaauccac cguuucagga auagc                       45


<210>  107
<211>  39
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 part2_partial_v1

<400>  107
caggguaugg ugguaucccg aacaauccac cguuucagg                              39


<210>  108
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 part3_v1

<400>  108
gcagcacugg uuuccagugc uguuuuu                                           27


<210>  109
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 part3_partial_v1

<400>  109
gcagcacugg uuuccagugc ugu                                               23


<210>  110
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 part3_without_polyt_v1

<400>  110
gcagcacugg uuuccagugc ug                                                22


<210>  111
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 sgRNA_v1

<400>  111
guuuugguuc ucugagaaac agaaguucua agauaaggcu uuacgccgca ggguauggug       60

guaucccgaa caauccaccg uuucaggaau agcgcagcac ugguuuccag ugcuguuuuu      120


<210>  112
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 crRNA_v2

<400>  112
guuuugguuc uucug                                                        15


<210>  113
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_crRNA_2_15_v2

<400>  113
guuuugguuc uu                                                           12


<210>  114
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_antirepeat_2_15_v2

<400>  114
aaguucuaag au                                                           12


<210>  115
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_antirepeat_3_15_v2

<400>  115
guucuaagau                                                              10


<210>  116
<211>  120
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 sgRNA_v2

<400>  116
guuuugguuc uucuggaaac agaaguucua agauaaggcu uuacgccgca ggguauggug       60

guaucccgaa caauccaccg uuucaggaau agcgcagcac ugguuuccag ugcuguuuuu      120


<210>  117
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 crRNA_v3

<400>  117
guuuugguuc ucugaugg                                                     18


<210>  118
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 tracRNA_v3

<400>  118
caucagaagu ucuaagau                                                     18


<210>  119
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_crRNA_1_15_v3

<400>  119
guuuugguuc ucuga                                                        15


<210>  120
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_antirepeat_1_15_v3

<400>  120
ucagaaguuc uaagau                                                       16


<210>  121
<211>  126
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 sgRNA_v3

<400>  121
guuuugguuc ucugauggga aacaucagaa guucuaagau aaggcuuuac gccgcagggu       60

auggugguau cccgaacaau ccaccguuuc aggaauagcg cagcacuggu uuccagugcu      120

guuuuu                                                                 126


<210>  122
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 crRNA_v4

<400>  122
gucuugguuc ucugaugg                                                     18


<210>  123
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_crRNA_1_15_v4

<400>  123
gucuugguuc ucuga                                                        15


<210>  124
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_crRNA_2_15_v4

<400>  124
gucuugguuc uc                                                           12


<210>  125
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 partial_crRNA_3_15_v4

<400>  125
gucuugguuc                                                              10


<210>  126
<211>  126
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-68 sgRNA_v4

<400>  126
gucuugguuc ucugauggga aacaucagaa guucuaagau aaggcuuuac gccgcagggu       60

auggugguau cccgaacaau ccaccguuuc aggaauagcg cagcacuggu uuccagugcu      120

guuuuu                                                                 126


<210>  127
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 tracRNA_v1

<400>  127
uuccgguaac                                                              10


<210>  128
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 part1_v1

<400>  128
aagguuuaga ccac                                                         14


<210>  129
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 part1_partial_v1

<400>  129
aagguuuaga cc                                                           12


<210>  130
<211>  37
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 part2_v1

<400>  130
aaaauggaac ggccucuucg ggggucguuc uuuuuuu                                37


<210>  131
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 part2_partial_v1

<400>  131
aaaauggaac ggccucuucg ggggucguuc uuuuuu                                 36


<210>  132
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 part2_without_polyt_v1

<400>  132
aaaauggaac ggccucuucg ggggucguuc                                        30


<210>  133
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 sgRNA_v1

<400>  133
guuccgguug aaauuccggu aacaagguuu agaccacaaa auggaacggc cucuucgggg       60

gucguucuuu uuuu                                                         74


<210>  134
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 crRNA_v2

<400>  134
guuccgguug ga                                                           12


<210>  135
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 tracRNA_v2

<400>  135
ucuuuccggu aac                                                          13


<210>  136
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 partial_crRNA_3_15_v2

<400>  136
guuccgguug                                                              10


<210>  137
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 partial_antirepeat_3_15_v2

<400>  137
uuuccgguaa c                                                            11


<210>  138
<211>  80
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-71 sgRNA_v2

<400>  138
guuccgguug gagaaaucuu uccgguaaca agguuuagac cacaaaaugg aacggccucu       60

ucgggggucg uucuuuuuuu                                                   80


<210>  139
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 crRNA_v1

<400>  139
guuuuuguac ucucaa                                                       16


<210>  140
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 tracRNA_v1

<400>  140
uugagaaucu acaaggau                                                     18


<210>  141
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_crRNA_1_15_v1

<400>  141
guuuuuguac ucuca                                                        15


<210>  142
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_antirepeat_1_15_v1

<400>  142
uugagaaucu acaaggau                                                     18


<210>  143
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_crRNA_2_15_v1

<400>  143
guuuuuguac uc                                                           12


<210>  144
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_antirepeat_2_15_v1

<400>  144
gaaucuacaa ggau                                                         14


<210>  145
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_crRNA_3_15_v1

<400>  145
guuuuuguac                                                              10


<210>  146
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_antirepeat_3_15_v1

<400>  146
aucuacaagg au                                                           12


<210>  147
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 part1_v1

<400>  147
aaggcuuuau gccgaaauca uu                                                22


<210>  148
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 part1_partial_v1

<400>  148
aaggcuuuau gcc                                                          13


<210>  149
<211>  24
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 part2_v1

<400>  149
aacucgccuu ugggcgaguu uuuu                                              24


<210>  150
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 part2_partial_v1

<400>  150
aacucgccuu ugggcgaguu                                                   20


<210>  151
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 part2_without_polyt_v1

<400>  151
aacucgccuu ugggcgag                                                     18


<210>  152
<211>  84
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 sgRNA_v1

<400>  152
guuuuuguac ucucaagaaa uugagaaucu acaaggauaa ggcuuuaugc cgaaaucauu       60

aacucgccuu ugggcgaguu uuuu                                              84


<210>  153
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 crRNA_v2

<400>  153
guuuuuguac ucucaacau                                                    19


<210>  154
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 tracRNA_v2

<400>  154
ugauugagaa ucuacaagga u                                                 21


<210>  155
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_antirepeat_1_15_v2

<400>  155
ugagaaucua caaggau                                                      17


<210>  156
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 sgRNA_v2

<400>  156
guuuuuguac ucucaacaug aaaugauuga gaaucuacaa ggauaaggcu uuaugccgaa       60

aucauuaacu cgccuuuggg cgaguuuuuu                                        90


<210>  157
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 crRNA_v3

<400>  157
guucuuguac ucucaacau                                                    19


<210>  158
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_crRNA_1_15_v3

<400>  158
guucuuguac ucuca                                                        15


<210>  159
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 partial_crRNA_2_15_v3

<400>  159
guucuuguac uc                                                           12


<210>  160
<211>  90
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-75 sgRNA_v3

<400>  160
guucuuguac ucucaacaug aaaugauuga gaaucuacaa ggauaaggcu uuaugccgaa       60

aucauuaacu cgccuuuggg cgaguuuuuu                                        90


<210>  161
<211>  18
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 crRNA_v1

<400>  161
guugcgguug gccugcga                                                     18


<210>  162
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 tracRNA_v1

<400>  162
ucgcagucca gccguuaac                                                    19


<210>  163
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 partial_crRNA_1_15_v1

<400>  163
guugcgguug gccug                                                        15


<210>  164
<211>  16
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 partial_antirepeat_1_15_v1

<400>  164
caguccagcc guuaac                                                       16


<210>  165
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 partial_crRNA_2_15_v1

<400>  165
guugcgguug gc                                                           12


<210>  166
<211>  13
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 partial_antirepeat_2_15_v1

<400>  166
uccagccguu aac                                                          13


<210>  167
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 partial_crRNA_3_15_v1

<400>  167
guugcgguug                                                              10


<210>  168
<211>  11
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 partial_antirepeat_3_15_v1

<400>  168
cagccguuaa c                                                            11


<210>  169
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 part1_v1

<400>  169
aagcugagau augcaccaga u                                                 21


<210>  170
<211>  14
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 part1_partial_v1

<400>  170
aagcugagau augc                                                         14


<210>  171
<211>  29
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 part2_v1

<400>  171
aaggcgcucg cuccggcgag cgcuuuuuu                                         29


<210>  172
<211>  26
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 part2_partial_v1

<400>  172
aaggcgcucg cuccggcgag cgcuuu                                            26


<210>  173
<211>  23
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 part2_without_polyt_v1

<400>  173
aaggcgcucg cuccggcgag cgc                                               23


<210>  174
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 sgRNA_v1

<400>  174
guugcgguug gccugcgaga aaucgcaguc cagccguuaa caagcugaga uaugcaccag       60

auaaggcgcu cgcuccggcg agcgcuuuuu u                                      91


<210>  175
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 crRNA_v2

<400>  175
guugcgguug gccugcgauu u                                                 21


<210>  176
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 tracRNA_v2

<400>  176
aaaucgcagu ccagccguua ac                                                22


<210>  177
<211>  97
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-78 sgRNA_v2

<400>  177
guugcgguug gccugcgauu ugaaaaaauc gcaguccagc cguuaacaag cugagauaug       60

caccagauaa ggcgcucgcu ccggcgagcg cuuuuuu                                97


<210>  178
<211>  34
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 crRNA_v1

<400>  178
gccgugguuu cccuaccgau uugcccaugg uagg                                   34


<210>  179
<211>  31
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 tracRNA_v1

<400>  179
guuaucggca aaucgguagg gaagccacgg u                                      31


<210>  180
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 partial_crRNA_1_15_v1

<400>  180
gccgugguuu cccua                                                        15


<210>  181
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 partial_antirepeat_1_15_v1

<400>  181
uagggaagcc acggu                                                        15


<210>  182
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 partial_crRNA_2_15_v1

<400>  182
gccgugguuu cc                                                           12


<210>  183
<211>  12
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 partial_antirepeat_2_15_v1

<400>  183
ggaagccacg gu                                                           12


<210>  184
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 partial_crRNA_3_15_v1

<400>  184
gccgugguuu                                                              10


<210>  185
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 partial_antirepeat_3_15_v1

<400>  185
aagccacggu                                                              10


<210>  186
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 part1_v1

<400>  186
aacagagcuu cacugugaag gaucauccug aaggggaaau uccuuauuga agcacug          57


<210>  187
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 part1_partial_v1

<400>  187
aacagagcuu cacugugaag gaucauccug aaggggaaau uccuuauuga agcacug          57


<210>  188
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 part2_v1

<400>  188
auacagagcu ucuguauuc                                                    19


<210>  189
<211>  17
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 part2_partial_v1

<400>  189
auacagagcu ucuguau                                                      17


<210>  190
<211>  38
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 part3_v1

<400>  190
aaacgacccu uucugagaua ucagagaggg ucguuuuu                               38


<210>  191
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 part3_partial_v1

<400>  191
aaacgacccu uucugagaua ucagagaggg ucguuu                                 36


<210>  192
<211>  33
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 part3_without_polyt_v1

<400>  192
aaacgacccu uucugagaua ucagagaggg ucg                                    33


<210>  193
<211>  183
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  OMNI-84 sgRNA_v1

<400>  193
gccgugguuu cccuaccgau uugcccaugg uagggaaagu uaucggcaaa ucgguaggga       60

agccacggua acagagcuuc acugugaagg aucauccuga aggggaaauu ccuuauugaa      120

gcacugauac agagcuucug uauucaaacg acccuuucug agauaucaga gagggucguu      180

uuu                                                                    183


<210>  194
<211>  6892
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pbNNC3-OMNI75

<400>  194
gttgtgccac gcggttggga atgtaattca gctccgccat cgccgcttcc actttttccc       60

gcgttttcgc agaaacgtgg ctggcctggt tcaccacgcg ggaaacggtc tgataagaga      120

caccggcata ctctgcgaca tcgtataacg ttactggttt cacattcacc accctgaatt      180

gactctcttc cgggcgctat catgccatac cgcgaaaggt tttgcgccat tcgatggtgt      240

cgggatctcg acgctaaatt aatacgactc actatagggg aattgtgagc ggataacaat      300

tcccctgtag aaataatttt gtttaactaa agaggagaaa tttcatatgt acccatacga      360

tgtgccagat tacgctggca ccgagctcgg taccacaaag tacagcgtcg gcctggacat      420

cggaatcgcc tcttgtggct ggtccatcat cgacatcgag aagaaagaga tcatcgacct      480

cggcagcaga atcttccctt ctggcaatgc cgccggaaac caggacagaa gaagcttcag      540

aggcaccaga cggctgatcc ggcggagaaa gaatagactg agcgacctga ccaagttcct      600

ggccgagaat ggcttcgccg tgtccaacga caagaatcag aacccctacg ctctgcggag      660

caaaggactg gccgaacagc tgtctaaaga ggaactggcc accgctctgt accacatcgt      720

gaacagaaga ggcatcagct acgacctggg cgacctggaa gatgatggca caagcggcgt      780

gtccgactac aagagcagca tcaacatcaa ccggcagctg ctgcgggaaa agaccatcgg      840

ccagattcag ctggaacggc tgaacgagtt tggccaagtg cggggacaag tgaaggccga      900

cgatgagaca accctgctga atgtgtttcc tagcgccgcc tatgccgacg aggccaagca      960

gattctggaa aagcaggccg agtactaccc cgagatcacc gacgagttta tcgccaagat     1020

caacgagctg atcacccgga agagagagta cttcgtcggc cctggcaacg agaagtccag     1080

aaccgactac ggcatctaca agaccgacgg cagaaccctg gacaacctgt tcgatgagct     1140

gatcggcacc gacaagatca atggcgagaa gagagccagc gccagctctc tgacagccca     1200

gatctacaat ctgctgaacg acctgaacaa cctgaccgtg cctaacaccg aggatggcaa     1260

gctgaccacc gagacaaaga aagaaatcct gtccgccgcc aagagagccg agggcatttt     1320

tggcaaggtg caaatctgca agctcatcgg cgtgaagttc gacgaactca agaccaagaa     1380

aggcggcgag atcgagttca agcacaccct gttcgcctac cggaagttca gaaaggccct     1440

ggccgaaagc aacatcgagg ccaatgatct gagcaccgag ttcttcgata agatcgccga     1500

catcctgaca ctgaacaccg agaaggccga gatccggaag cagctggata aggccgattt     1560

cgccatcagc gacgaagtga aagaactgat cgtgaaagag aacaagaacc tgctggtgga     1620

cggcagagcc acctggcaca gctttagcta taagaccctg aacctgctca tccccgagct     1680

gctgaatacc agcgacgagc agatgaccat tctgaccggc ctgggcctga tgaagcccga     1740

taatgagaag taccagggcc tgaagaacat ccctgccgct cagattaccg aagagatcta     1800

taaccccgtg gtggccaaga gcacccgcga ggccatcaac gtgttcaacg ccattgccaa     1860

aagagtgggc gccgagaata tcgcccacgt ggtcattgag ctgcccagag aggataacga     1920

ggacgacgtg aagaagcaga agatcaagtt ccagaaggcc caagaggccg aaaagaacgc     1980

cgccgatgaa ctggtcaagc agcaaatgac aatccccgac tctagcctgc tggcccagta     2040

cagaaagttc aagggcctga gccagaaagt gcggtactgg tatcagcaag agacattctg     2100

cccctactgc ggcgagaaaa tcaaagtgat ccagctgatc aacaacaacg agagcttcga     2160

gatcgaccac atcatcccca tcagcgtgtc cttcgacgac agccagaaca acaaggtgct     2220

ggtgcacagc cagtgcaacc aggccaaaga gaagcagaca cccctcggct ggatcaacaa     2280

tggcggaggc tttggacaga ccaaagccga gtatattgcc cgcgtgaagg ccaacaagaa     2340

tttcaacaag aacaaggtcg acaacctcct gaacgacgcc gacctgaatg acatcatcac     2400

ccggcggagc ttcatccagc ggaacctgaa cgataccaga tacgccagca gagtggtgct     2460

ggacgagttc tacagcttct tcaagagcaa ccatctgccg accaaagtga aggtcgtcag     2520

aggcaagtgg acaagccaga tgcggaagaa gtggaactct gccggcggac tggccaagac     2580

cagagataca caccaccacc acgccatcga cgcctctatc attgccagct ttccactgct     2640

gaaggccttt gacaaggccg tgaagctgat cgacattgac aaagagacag gcgagattct     2700

gcaggacaaa gccgccgtga agaaagccag agaagccgaa ctgctggctc agtgggctat     2760

ccccaacgag aaagagttcg agaagctgga cagcgagatc ttcgacttcc cactgttcaa     2820

gcaggtcgag ctggccaacg acatcgacga ccctgagaac cctgtgaagt tctcccacaa     2880

ggtggacaaa aaggccaata gagccgtggc caaccagacc atctacggca ccagaatgaa     2940

ggaaaccgag gtcgtcaagc ggggcaagac cgaaatcgtg caggacgagt acatcttcgg     3000

gaccatcaag aacatctaca acgtggacga cttcgccaag ttcaagaaac tgtacgatga     3060

ggccctcaag aaagaggacg tcaagttcct catgcaagag aaggacccca agacctggga     3120

gaaactgctc aagatcctga agaatacccc ggacttcgag gaaaagacac agacagacgg     3180

caaagtgaaa gtgattcccg tgtcaccctt cgagctgtac agaagagaga acggctttat     3240

caccaaatac gccaagcaca acaacggccc caaggtggtg tccctgaagt actacgatag     3300

caagatcggc agccacatcg atatcacccc agagaacgcc cggaacaagg tggtcctgca     3360

gtctctgaag ccttggcgga ccgacgtgta ctacaacccc gatacacagc agtatgagct     3420

gctgggactg aagtacgccg atctgaagtt caccaagggc gtgtacggca tcaccgagga     3480

agcctacgag aaactgaagc acggaatcga ggccgacggc accatcctgt ggaagcctat     3540

cggcagaaac agcgagttcc ggttctccct gtaccggaac gacagagtga agatcgtgga     3600

cgataagggc gaagagattg aactgctgtt tggcagcaga gccggcaaca atgagggcta     3660

cgtggaaatg aagcccatcc acaaggccag atttgagggc gctgaggaaa tcgccttcta     3720

cggcaagacc agcagcggca gatttctgaa gccactggcc aaaaagggct acaagctgta     3780

caaagtgaac accggcatcc tgggcacccc ttactacaca gagaaagaga gcgaccagcc     3840

taagctgaac ctgggatccc caaaaaagaa aagaaaagtt gctgccgcac tcgagcatca     3900

tcaccatcac catcatcatt aagcggccgc ctagcataac cccttggggc ctctaaacgg     3960

gtcttgaggg gttttttgac ctaggctagg ggatatattc cgcttcctcg ctcactgact     4020

cgctacgctc ggtcgttcga ctgcggcgag cggaaatggc ttacgaacgg ggcggagatt     4080

tcctggaaga tgccaggaag atacttaaca gggaagtgag agggccgcgg caaagccgtt     4140

tttccatagg ctccgccccc ctgacaagca tcacgaaatc tgacgctcaa atcagtggtg     4200

gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggcggct ccctcgtgcg     4260

ctctcctgtt cctgcctttc ggtttaccgg tgtcattccg ctgttatggc cgcgtttgtc     4320

tcattccacg cctgacactc agttccgggt aggcagttcg ctccaagctg gactgtatgc     4380

acgaaccccc cgttcagtcc gaccgctgcg ccttatccgg taactatcgt cttgagtcca     4440

acccggaaag acatgcaaaa gcaccactgg cagcagccac tggtaattga tttagaggag     4500

ttagtcttga agtcatgcgc cggttaaggc taaactgaaa ggacaagttt tggtgactgc     4560

gctcctccaa gccagttacc tcggttcaaa gagttggtag ctcagagaac cttcgaaaaa     4620

ccgccctgca aggcggtttt ttcgttttca gagcaagaga ttacgcgcag accaaaacga     4680

tctcaagaag atcatcttat taatcagata aaatatttct agatttcagt gcaatttatc     4740

tcttcaaatg tagcacctga agtcagcccc atacgatata agttgttact agtgcttgga     4800

ttctcaccaa taaaaaacgc ccggcggcaa ccgagcgttc tgaacaaatc cagatggagt     4860

tctgaggtca ttactggatc tatcaacagg agtccaagcg agctcgtaaa cttggtctga     4920

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     4980

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     5040

ccccagtgct gcaatgatac cgcgggagcc acgctcaccg gctccagatt tatcagcaat     5100

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     5160

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     5220

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     5280

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     5340

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     5400

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     5460

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     5520

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     5580

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag     5640

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac     5700

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc     5760

gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca     5820

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     5880

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc ctcgagtccc ggtgcctaat     5940

gagtgagcta acttacatta attgcgttgc gctcactgcc cgctttccag tcgggaaacc     6000

tgtcgtgcca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg     6060

ggcgccaggg tggtttttct tttcaccagt gacacgggca acagctgatt gcccttcacc     6120

gcctggccct gagagagttg cagcaagcgg tccacgctgg tttgccccag caggcgaaaa     6180

tcctgtttga tggtggttaa cggcgggata taacatgagc tgtcttcggt atcgtcgtat     6240

cccactaccg agatgtccgc accaacgcgc agcccggact cggtaatggc gcgcattgcg     6300

cccagcgcca tctgatcgtt ggcaaccagc atcgcagtgg gaacgatgcc ctcattcagc     6360

atttgcatgg tttgttgaaa accggacatg gcactccagt cgccttcccg ttccgctatc     6420

ggctgaattt gattgcgagt gagatattta tgccagccag ccagacgcag acgcgccgag     6480

acagaactta atgggcccgc taacagcgcg atttgctggt gacccaatgc gaccagatgc     6540

tccacgccca gtcgcgtacc gtcttcatgg gagaaaataa tactgttgat gggtgtctgg     6600

tcagagacat caagaaataa cgccggaaca ttagtgcagg cagcttccac agcaatggca     6660

tcctggtcat ccagcggata gttaatgatc agcccactga cgcgttgcgc gagaagattg     6720

tgcaccgccg ctttacaggc ttcgacgccg cttcgttcta ccatcgacac caccacgctg     6780

gcacccagtt gatcggcgcg agatttaatc gccgcgacaa tttgcgacgg cgcgtgcagg     6840

gccagactgg aggtggcaac gccaatcagc aacgactgtt tgcccgccag tt             6892


<210>  195
<211>  2551
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pbSGR2-T2-OMNI75 V1

<400>  195
gcataaccaa gcctatgcct acagcatcca gggtgacggt gccgaggatg acgatgagcg       60

cattgttaga tttcatacac ggtgcctgac tgcgttagca atttaactgt gataaactac      120

cgcattaaag cttatcgatg ataagctgtc aacacatttc cccgaaaagt gccacctgac      180

gtcctcgagt cccgcataat cgaaattaat acgactcact atagggaaga gcagagcctt      240

ggtctcgttt ggttaccata tgattgaaaa tttatatgac ctaaccaaac aagggtttat      300

cccggactcg gctcttcgga gcctttttga attcttccgc tgagcaataa ctagcataac      360

cccttggggc ctctaaacgg gtcttgaggg gttttttgac ctaggctagg ggatatattc      420

cgcttcctcg cggtaccccg cttcctcgct cactgactcg ctacgctcgg tcgttcgact      480

gcggcgagcg gaaatggctt acgaacgggg cggagatttc ctggaagatg ccaggaagat      540

acttaacagg gaagtgagag ggccgcggca aagccgtttt tccataggct ccgcccccct      600

gacaagcatc acgaaatctg acgctcaaat cagtggtggc gaaacccgac aggactataa      660

agataccagg cgtttccccc tggcggctcc ctcgtgcgct ctcctgttcc tgcctttcgg      720

tttaccggtg tcattccgct gttatggccg cgtttgtctc attccacgcc tgacactcag      780

ttccgggtag gcagttcgct ccaagctgga ctgtatgcac gaaccccccg ttcagtccga      840

ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggaaagac atgcaaaagc      900

accactggca gcagccactg gtaattgatt tagaggagtt agtcttgaag tcatgcgccg      960

gttaaggcta aactgaaagg acaagttttg gtgactgcgc tcctccaagc cagttacctc     1020

ggttcaaaga gttggtagct cagagaacct tcgaaaaacc gccctgcaag gcggtttttt     1080

cgttttcaga gcaagagatt acgcgcagac caaaacgatc tcaagaagat catcttatta     1140

atcagataaa atatttctag atttcagtgc aatttatctc ttcaaatgta gcacctgaag     1200

tcagccccat acgatataag ttgttactag tgcttggatt ctcaccaata aaaaacgccc     1260

ggcggcaacc gagcgttctg aacaaatcca gatggagttc tgaggtcatt actggatcta     1320

tcaacaggag tccaagcgag aagggttggt ttgcgcattc acagttctcc gcaagaattg     1380

attggctcca attcttggag tggtgaatcc gttagcgagg tgccgccggc ttccattcag     1440

gtcgaggtgg cccggctcca tgcaccgcga cgcaacgcgg ggaggcagac aaggtatagg     1500

gcggcgccta caatccatgc caacccgttc catgtgctcg ccgaggcggc ataaatcgcc     1560

gtgacgatca gcggtccaat gatcgaagtt aggctggtaa gagccgcgag cgatccttga     1620

agctgtccct gatggtcgtc atctacctgc ctggacagca tggcctgcaa cgcgggcatc     1680

ccgatgccgc cggaagcgag aagaatcata atggggaagg ccatccagcc tcgcgtcgcg     1740

aacgccagca agacgtagcc cagcgcgtcg gccgccatgc cggcgataat ggcctgcttc     1800

tcgccgaaac gtttggtggc gggaccagtg acgaaggctt gagcgagggc gtgcaagatt     1860

ccgaataccg caagcgacag gccgatcatc gtcgcgctcc agcgaaagcg gtcctcgccg     1920

aaaatgaccc agagcgctgc cggcacctgt cctacgagtt gcatgataaa gaagacagtc     1980

ataagtgcgg cgacgatagt catgccccgc gcccaccgga aggagctgac tgggttgaag     2040

gctctcaagg gcatcggtcg acgctctccc ttatgcgact cctgcattag gaagcagccc     2100

agtagtaggt tgaggccgtt gagcaccgcc gccgcaagga atggtgcatg caaggagatg     2160

gcgcccaaca gtcccccggc cacggggcct gccaccatac ccacgccgaa acaagcgctc     2220

atgagcccga agtggcgagc ccgatcttcc ccatcggtga tgtcggcgat ataggcgcca     2280

gcaaccgcac ctgtggcgcc ggtgatgccg gccacgatgc gtccggcgta gaggatccac     2340

aggacgggtg tggtcgccat gatcgcgtag tcgatagtgg ctccaagtag cgaagcgagc     2400

aggactgggc ggcggccaaa gcggtcggac agtgctccga gaacgggtgc gcatagaaat     2460

tgcatcaacg catatagcgc tagcagcacg ccatagtgac tggcgatgct gtcggaatgg     2520

acgatatccc gcaagaggcc cggcagtacc g                                    2551


<210>  196
<211>  5009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pbPOS T2 library


<220>
<221>  misc_feature
<222>  (3040)..(3047)
<223>  n is a, c, g, or t

<400>  196
tcgagtcttt acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac       60

aatttcacac atgattacgg attcaacgtc gtgactggta aaacccgggc gttacccaac      120

ttaatcgcct tgcagcacat ccccctttcg ccagcaggcg taataaggaa aggattcatg      180

tactatttga aaaacacaaa cttttggatg ttcggtttat tctttttctt ttactttttt      240

atcatgggag cctacttccc gtttttcccg atttggctac atgatatcaa ccatatcagc      300

aaaagtgata cgggtattat ttttgccgct atttctctgt tctcgctatt attccaaccg      360

ctgtttggtc tgctttctga caaactcggt ctacgcaaat acctgctgtg gattattacc      420

ggcatgttag tgatgtttgc gccgttcttt atttttatct tcgggccact gctgcagtac      480

aacattttag tagggtcgat tgttggtggt atttatctag gctttagttt taacgccggt      540

gcgccagcag tagaggcatt tattgagaaa gtcagccggc gcagtaattt cgaatttggt      600

cgcgcgcgga tgtttggcag tgttggctgg gcgctggttg cctcgattgt cgggatcatg      660

ttcaccatta ataatcagtt tgttttctgg ctgggctctg gcagttgtct catcctcgcc      720

gttttactct ttttcgccaa aacggacgcg ccctcaagtg ccacggttgc caatgcggta      780

ggtgccaacc attcggcatt tagccttaag ctggcactgg aactgttcag acagccaaaa      840

ctgtggtttt tgtcactgta tgttattggc gtttcctcca cctacgatgt ttttgaccaa      900

cagtttgcta atttctttac ttcgttcttt gctaccggtg aacagggtac ccgcgtattt      960

ggctacgtaa cgacaatggg cgaattactt aacgcctcga ttatgttctt tgcgccactg     1020

atcattaatc gcatcggtgg gaagaatgcc ctgctgctgg ctggcactat tatgtctgta     1080

cgtattattg gctcatcgtt cgccacctca gcgctggaag tggttattct gaaaacgctg     1140

catatgtttg aagtaccgtt cctgctggtg ggctccttta aatatattac tagtcagttt     1200

gaagtgcgtt tttcagcgac gatttatctg gtcagtttca gcttctttaa gcaactggcg     1260

atgattttta tgtctgtact ggcgggcaat atgtatgaaa gcataggttt ccaaggcgct     1320

tatctggtgc tgggtctggt ggcgctgggc ttcaccttaa tttccgtgtt cacgcttagc     1380

ggcccgggcc cgctttccct gctgcgtcgt caggtgaatg aagtcgctta aaggcctcga     1440

tgcagctagc atgctaatct gattcgttac caattatgac aacttgacgg ctacatcatt     1500

cactttttct tcacaaccgg cacggaactc gctcgggctg gccccggtgc attttttaaa     1560

tacccgcgag aaatagagtt gatcgtcaaa accaacattg cgaccgacgg tggcgatagg     1620

catccgggtg gtgctcaaaa gcagcttcgc ctggctgata cgttggtcct cgcgccagct     1680

taagacgcta atccctaact gctggcggaa aagatgtgac agacgcgacg gcgacaagca     1740

aacatgctgt gcgacgctgg cgatatcaaa attgctgtct gccaggtgat cgctgatgta     1800

ctgacaagcc tcgcgtaccc gattatccat cggtggatgg agcgactcgt taatcgcttc     1860

catgcgccgc agtaacaatt gctcaagcag atttatcgcc agcagctccg aatagcgccc     1920

ttccccttgc ccggcgttaa tgatttgccc aaacaggtcg ctgaaatgcg gctggtgcgc     1980

ttcatccggg cgaaagaacc ccgtattggc aaatattgac ggccagttaa gccattcatg     2040

ccagtaggcg cgcggacgaa agtaaaccca ctggtgatac cattcgcgag cctccggatg     2100

acgaccgtag tgatgaatct ctcctggcgg gaacagcaaa atatcacccg gtcggcaaac     2160

aaattctcgt ccctgatttt tcaccacccc ctgaccgcga atggtgagat tgagaatata     2220

acctttcatt cccagcggtc ggtcgataaa aaaatcgaga taaccgttgg cctcaatcgg     2280

cgttaaaccc gccaccagat gggcattaaa cgagtatccc ggcagcaggg gatcattttg     2340

cgcttcagcc atacttttca tactcccgcc attcagagaa gaaaccaatt gtccatattg     2400

catcagacat tgccgtcact gcgtctttta ctggctcttc tcgctaacca aaccggtaac     2460

cccgcttatt aaaagcattc tgtaacaaag cgggaccaaa gccatgacaa aaacgcgtaa     2520

caaaagtgtc tataatcacg gcagaaaagt ccacattgat tatttgcacg gcgtcacact     2580

ttgctatgcc atagcatttt tatccataag attagcggat cctacctgac gctttttatc     2640

gcaactctct actgtttctc catacccgtt tttttggggt agcgattgaa aacgatgcag     2700

tttaaggttt acacctataa aagagagagc cgttatcgtc tgtttgtgga tgtacagagt     2760

gatattattg acacgcccgg gcgacggatg gtgatccccc tggccagtgc acgtctgctg     2820

tcagataaag tctcccgtga actttacccg gtggtgcata tcggggatga aagctggcgc     2880

atgatgacca ccgatatggc cagtgtgccg gtctccgtta tcggggaaga agtggctgat     2940

ctcagccacc gcgaaaatga catcaaaaac gccattaacc tgatgttttg gggaatataa     3000

tcttctagac atacaatgga agagcagagc cttggtctcn nnnnnnnaag cttgatatcg     3060

aattcctgca gcccggggga tcccatggta cgcgtgctag aggcatcaaa taaaacgaaa     3120

ggctcagtcg aaagactggg cctttcgttt tatctgttgt ttgtcggtga acgctctcct     3180

gagtaggaca aatccgccgc cctagaccta ggcgttcggc tgcggcgagc ggtatcagct     3240

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     3300

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     3360

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     3420

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     3480

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     3540

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     3600

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     3660

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     3720

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     3780

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     3840

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     3900

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     3960

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     4020

actagtgctt ggattctcac caataaaaaa cgcccggcgg caaccgagcg ttctgaacaa     4080

atccagatgg agttctgagg tcattactgg atctatcaac aggagtccaa gcgagctcga     4140

tatcaaatta cgccccgccc tgccactcat cgcagtactg ttgtaattca ttaagcattc     4200

tgccgacatg gaagccatca cagacggcat gatgaacctg aatcgccagc ggcatcagca     4260

ccttgtcgcc ttgcgtataa tatttgccca tggtgaaaac gggggcgaag aagttgtcca     4320

tattggccac gtttaaatca aaactggtga aactcaccca gggattggct gagacgaaaa     4380

acatattctc aataaaccct ttagggaaat aggccaggtt ttcaccgtaa cacgccacat     4440

cttgcgaata tatgtgtaga aactgccgga aatcgtcgtg gtattcactc cagagcgatg     4500

aaaacgtttc agtttgctca tggaaaacgg tgtaacaagg gtgaacacta tcccatatca     4560

ccagctcacc gtctttcatt gccatacgga attccggatg agcattcatc aggcgggcaa     4620

gaatgtgaat aaaggccgga taaaacttgt gcttattttt ctttacggtc tttaaaaagg     4680

ccgtaatatc cagctgaacg gtctggttat aggtacattg agcaactgac tgaaatgcct     4740

caaaatgttc tttacgatgc cattgggata tatcaacggt ggtatatcca gtgatttttt     4800

tctccatttt agcttcctta gctcctgaaa atctcgataa ctcaaaaaat acgcccggta     4860

gtgatcttat ttcattatgg tgaaagttgg aacctcttac gtgccgatca acgtctcatt     4920

ttcgccagat atcgacgtct aagaaaccat tattatcatg acattaacct ataaaaatag     4980

gcgtatcacg aggccctttc gtcttcacc                                       5009


<210>  197
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_CXCR4_S10 Spacer sequence

<400>  197
cctaacgtcc caaacgcgcc aa                                                22


<210>  198
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_CXCR4_S11 Spacer sequence

<400>  198
ggtcggccac tgacaggtgc ag                                                22


<210>  199
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_PDCD1_S11 Spacer sequence

<400>  199
aaccatcctg gccgccagcc ca                                                22


<210>  200
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_PDCD1_S12 Spacer sequence

<400>  200
gggcccggcg caatgacagc gg                                                22


<210>  201
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_TRAC_S10 Spacer sequence

<400>  201
accagcttga catcacagga ac                                                22


<210>  202
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_TRAC_S11 Spacer sequence

<400>  202
gccgtgtacc agctgagaga ct                                                22


<210>  203
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_CXCR4_S13 Spacer sequence

<400>  203
tgggttacca gaagaaactg ag                                                22


<210>  204
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_CXCR4_S14 Spacer sequence

<400>  204
aaacgcgcca agtgataaac ac                                                22


<210>  205
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_PDCD1_S14 Spacer sequence

<400>  205
gtgctacaac tgggctggcg gc                                                22


<210>  206
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_PDCD1_S15 Spacer sequence

<400>  206
ctggccccca aggcgcagat ca                                                22


<210>  207
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_TRAC_S14 Spacer sequence

<400>  207
tacacggcag ggtcagggtt ct                                                22


<210>  208
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_TRAC_S15 Spacer sequence

<400>  208
taaacccggc cactttcagg ag                                                22


<210>  209
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_CXCR4_S3 Spacer sequence

<400>  209
cgccaagtga taaacacgag ga                                                22


<210>  210
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_CXCR4_S12 Spacer sequence

<400>  210
catcctggtc atgggttacc ag                                                22


<210>  211
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_PDCD1_S13 Spacer sequence

<400>  211
cagacgactg gccagggcgc ct                                                22


<210>  212
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_PDCD1_S4 Spacer sequence

<400>  212
taaactggta ccgcatgagc cc                                                22


<210>  213
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_TRAC_S12 Spacer sequence

<400>  213
cggccacttt caggaggagg at                                                22


<210>  214
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_TRAC_S13 Spacer sequence

<400>  214
ctgaccctgc cgtgtaccag ct                                                22


<210>  215
<211>  421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_CXCR4_S10 PAM containing genomic seq

<400>  215
ggaaatgaaa cttggggcga ggaccacggg tgcagacccc gttaccttct ccacccagga       60

aaatgccccg ctccctaacg tcccaaacgc gccaagtgat aaacacgagg atggcaagag      120

acccacacac cggaggagcg cccgcttggg ggaggaggtg ccgtttgttc attttctgac      180

actcccgccc aatatacccc aagcaccgaa gggccttcgt tttaagaccg cattctcttt      240

acccactaca agttgcttga agcccagaat ggtttgtatt taggcaggcg tgggaaaatt      300

aagtttttgc gctttaggag aatgagtctt tgcaacgccc ccgccctccc cccgtgatcc      360

tcccttctcc cctcttccct ccctgggcga aaaacttctt acaaaaagtt aatcactgcc      420

c                                                                      421


<210>  216
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_CXCR4_S11 PAM containing genomic seq

<400>  216
cctgcccacc atctactcca tcatcttctt aactggcatt gtgggcaatg gattggtcat       60

cctggtcatg ggttaccaga agaaactgag aagcatgacg gacaagtaca ggctgcacct      120

gtcagtggcc gacctcctct ttgtcatcac gcttcccttc tgggcagttg atgccgtggc      180

aaactggtac tttgggaact tcctatgcaa ggcagtccat gtcatctaca cagtcaacct      240

ctacagcagt gtcctcatcc tggccttcat cagtctggac cgctacctgg ccatcgtcca      300

cgccaccaac agtcagaggc caaggaagct gttggctgaa aaggtggtct atgttggcgt      360

ctggatccct gccctcctgc tgactattcc cgacttcatc tttgccaacg tcagtgaggc      420

agatgacaga tatatctgtg accgcttcta ccccaatgac ttgtgggtgg ttgtgttcca      480


<210>  217
<211>  386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_PDCD1_S11 PAM containing genomic seq

<400>  217
gctcacctcc gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc       60

agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag      120

gatggttctt aggtaggtgg ggtcggcggt caggtgtccc agagccaggg gtctggaggg      180

accttccacc ctcagtccct ggcaggtcgg ggggtgctga ggcgggcctg gccctggcag      240

cccaggggtc ccggagcgag gggtctggag ggacctttca ctctcagtcc ctggcaggtc      300

ggggggtgct gtggcaggcc cagccttggc ccccagctct gccccttacc ctgagctgtg      360

tggctttggg cagctcgaac tcctgg                                           386


<210>  218
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_PDCD1_S12 PAM containing genomic seq

<400>  218
ttccccgagg accgcagcca gcccggccag gactgccgct tccgtgtcac acaactgccc       60

aacgggcgtg acttccacat gagcgtggtc agggcccggc gcaatgacag cggcacctac      120

ctctgtgggg ccatctccct ggcccccaag gcgcagatca aagagagcct gcgggcagag      180

ctcagggtga caggtgcggc ctcggaggcc ccggggcagg ggtgagctga gccggtcctg      240

gggtgggtgt cccctcctgc acaggatcag gagctccagg gtcgtagggc agggaccccc      300

cagctccagt ccagggctct gtcctgcacc tggggaatgg tgaccggcat ctctgtcctc      360

tagctctgg                                                              369


<210>  219
<211>  447
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_TRAC_S10 PAM containing genomic seq

<400>  219
gcctgctctg gatgctgaaa gaatgtctgt ttttcctttt agaaagttcc tgtgatgtca       60

agctggtcga gaaaagcttt gaaacaggta agacaggggt ctagcctggg tttgcacagg      120

attgcggaag tgatgaaccc gcaataaccc tgcctggatg agggagtggg aagaaattag      180

tagatgtggg aatgaatgat gaggaatgga aacagcggtt caagacctgc ccagagctgg      240

gtggggtctc tcctgaatcc ctctcaccat ctctgacttt ccattctaag cactttgagg      300

atgagtttct agcttcaata gaccaaggac tctctcctag gcctctgtat tcctttcaac      360

agctccactg tcaagagagc cagagagagc ttctgggtgg cccagctgtg aaatttctga      420

gtcccttagg gatagcccta aacgaac                                          447


<210>  220
<211>  463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI68_TRAC_S11 PAM containing genomic seq

<400>  220
cctgggttgg ggcaaagagg gaaatgagat catgtcctaa ccctgatcct cttgtcccac       60

agatatccag aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa      120

gtctgtctgc ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc      180

tgatgtgtat atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa      240

cagtgctgtg gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag      300

cattattcca gaagacacct tcttccccag cccaggtaag ggcagctttg gtgccttcgc      360

aggctgtttc cttgcttcag gaatggccag gttctgccca gagctctggt caatgatgtc      420

taaaactcct ctgattggtg gtctcggcct tatccattgc cac                        463


<210>  221
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_CXCR4_S13 PAM containing genomic seq

<400>  221
cctgcccacc atctactcca tcatcttctt aactggcatt gtgggcaatg gattggtcat       60

cctggtcatg ggttaccaga agaaactgag aagcatgacg gacaagtaca ggctgcacct      120

gtcagtggcc gacctcctct ttgtcatcac gcttcccttc tgggcagttg atgccgtggc      180

aaactggtac tttgggaact tcctatgcaa ggcagtccat gtcatctaca cagtcaacct      240

ctacagcagt gtcctcatcc tggccttcat cagtctggac cgctacctgg ccatcgtcca      300

cgccaccaac agtcagaggc caaggaagct gttggctgaa aaggtggtct atgttggcgt      360

ctggatccct gccctcctgc tgactattcc cgacttcatc tttgccaacg tcagtgaggc      420

agatgacaga tatatctgtg accgcttcta ccccaatgac ttgtgggtgg ttgtgttcca      480


<210>  222
<211>  421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_CXCR4_S14 PAM containing genomic seq

<400>  222
ggaaatgaaa cttggggcga ggaccacggg tgcagacccc gttaccttct ccacccagga       60

aaatgccccg ctccctaacg tcccaaacgc gccaagtgat aaacacgagg atggcaagag      120

acccacacac cggaggagcg cccgcttggg ggaggaggtg ccgtttgttc attttctgac      180

actcccgccc aatatacccc aagcaccgaa gggccttcgt tttaagaccg cattctcttt      240

acccactaca agttgcttga agcccagaat ggtttgtatt taggcaggcg tgggaaaatt      300

aagtttttgc gctttaggag aatgagtctt tgcaacgccc ccgccctccc cccgtgatcc      360

tcccttctcc cctcttccct ccctgggcga aaaacttctt acaaaaagtt aatcactgcc      420

c                                                                      421


<210>  223
<211>  386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_PDCD1_S14 PAM containing genomic seq

<400>  223
gctcacctcc gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc       60

agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag      120

gatggttctt aggtaggtgg ggtcggcggt caggtgtccc agagccaggg gtctggaggg      180

accttccacc ctcagtccct ggcaggtcgg ggggtgctga ggcgggcctg gccctggcag      240

cccaggggtc ccggagcgag gggtctggag ggacctttca ctctcagtcc ctggcaggtc      300

ggggggtgct gtggcaggcc cagccttggc ccccagctct gccccttacc ctgagctgtg      360

tggctttggg cagctcgaac tcctgg                                           386


<210>  224
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_PDCD1_S15 PAM containing genomic seq

<400>  224
ttccccgagg accgcagcca gcccggccag gactgccgct tccgtgtcac acaactgccc       60

aacgggcgtg acttccacat gagcgtggtc agggcccggc gcaatgacag cggcacctac      120

ctctgtgggg ccatctccct ggcccccaag gcgcagatca aagagagcct gcgggcagag      180

ctcagggtga caggtgcggc ctcggaggcc ccggggcagg ggtgagctga gccggtcctg      240

gggtgggtgt cccctcctgc acaggatcag gagctccagg gtcgtagggc agggaccccc      300

cagctccagt ccagggctct gtcctgcacc tggggaatgg tgaccggcat ctctgtcctc      360

tagctctgg                                                              369


<210>  225
<211>  463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_TRAC_S14 PAM containing genomic seq

<400>  225
cctgggttgg ggcaaagagg gaaatgagat catgtcctaa ccctgatcct cttgtcccac       60

agatatccag aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa      120

gtctgtctgc ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc      180

tgatgtgtat atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa      240

cagtgctgtg gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag      300

cattattcca gaagacacct tcttccccag cccaggtaag ggcagctttg gtgccttcgc      360

aggctgtttc cttgcttcag gaatggccag gttctgccca gagctctggt caatgatgtc      420

taaaactcct ctgattggtg gtctcggcct tatccattgc cac                        463


<210>  226
<211>  485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI78_TRAC_S15 PAM containing genomic seq

<400>  226
gacatgcaag cccataaccg ctgtggcctc ttggttttac agatacgaac ctaaactttc       60

aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg tttaatctgc      120

tcatgacgct gcggctgtgg tccagctgag gtgaggggcc ttgaagctgg gagtggggtt      180

tagggacgcg ggtctctggg tgcatcctaa gctctgagag caaacctccc tgcagggtct      240

tgcttttaag tccaaagcct gagcccacca aactctccta cttcttcctg ttacaaattc      300

ctcttgtgca ataataatgg cctgaaacgc tgtaaaatat cctcatttca gccgcctcag      360

ttgcacttct cccctatgag gtaggaagaa cagttgttta gaaacgaaga aactgaggcc      420

ccacagctaa tgagtggagg aagagagaca cttgtgtaca ccacatgcct tgtgttgtac      480

ttctc                                                                  485


<210>  227
<211>  421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_CXCR4_S3 PAM containing genomic seq

<400>  227
ggaaatgaaa cttggggcga ggaccacggg tgcagacccc gttaccttct ccacccagga       60

aaatgccccg ctccctaacg tcccaaacgc gccaagtgat aaacacgagg atggcaagag      120

acccacacac cggaggagcg cccgcttggg ggaggaggtg ccgtttgttc attttctgac      180

actcccgccc aatatacccc aagcaccgaa gggccttcgt tttaagaccg cattctcttt      240

acccactaca agttgcttga agcccagaat ggtttgtatt taggcaggcg tgggaaaatt      300

aagtttttgc gctttaggag aatgagtctt tgcaacgccc ccgccctccc cccgtgatcc      360

tcccttctcc cctcttccct ccctgggcga aaaacttctt acaaaaagtt aatcactgcc      420

c                                                                      421


<210>  228
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_CXCR4_S12 PAM containing genomic seq

<400>  228
cctgcccacc atctactcca tcatcttctt aactggcatt gtgggcaatg gattggtcat       60

cctggtcatg ggttaccaga agaaactgag aagcatgacg gacaagtaca ggctgcacct      120

gtcagtggcc gacctcctct ttgtcatcac gcttcccttc tgggcagttg atgccgtggc      180

aaactggtac tttgggaact tcctatgcaa ggcagtccat gtcatctaca cagtcaacct      240

ctacagcagt gtcctcatcc tggccttcat cagtctggac cgctacctgg ccatcgtcca      300

cgccaccaac agtcagaggc caaggaagct gttggctgaa aaggtggtct atgttggcgt      360

ctggatccct gccctcctgc tgactattcc cgacttcatc tttgccaacg tcagtgaggc      420

agatgacaga tatatctgtg accgcttcta ccccaatgac ttgtgggtgg ttgtgttcca      480


<210>  229
<211>  386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_PDCD1_S13 PAM containing genomic seq

<400>  229
gctcacctcc gcctgagcag tggagaaggc ggcactctgg tggggctgct ccaggcatgc       60

agatcccaca ggcgccctgg ccagtcgtct gggcggtgct acaactgggc tggcggccag      120

gatggttctt aggtaggtgg ggtcggcggt caggtgtccc agagccaggg gtctggaggg      180

accttccacc ctcagtccct ggcaggtcgg ggggtgctga ggcgggcctg gccctggcag      240

cccaggggtc ccggagcgag gggtctggag ggacctttca ctctcagtcc ctggcaggtc      300

ggggggtgct gtggcaggcc cagccttggc ccccagctct gccccttacc ctgagctgtg      360

tggctttggg cagctcgaac tcctgg                                           386


<210>  230
<211>  494
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_PDCD1_S4 PAM containing genomic seq

<400>  230
ccctgctcgt ggtgaccgaa ggggacaacg ccaccttcac ctgcagcttc tccaacacat       60

cggagagctt cgtgctaaac tggtaccgca tgagccccag caaccagacg gacaagctgg      120

ccgccttccc cgaggaccgc agccagcccg gccaggactg ccgcttccgt gtcacacaac      180

tgcccaacgg gcgtgacttc cacatgagcg tggtcagggc ccggcgcaat gacagcggca      240

cctacctctg tggggccatc tccctggccc ccaaggcgca gatcaaagag agcctgcggg      300

cagagctcag ggtgacaggt gcggcctcgg aggccccggg gcaggggtga gctgagccgg      360

tcctggggtg ggtgtcccct cctgcacagg atcaggagct ccagggtcgt agggcaggga      420

ccccccagct ccagtccagg gctctgtcct gcacctgggg aatggtgacc ggcatctctg      480

tcctctagct ctgg                                                        494


<210>  231
<211>  485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_TRAC_S12 PAM containing genomic seq

<400>  231
gacatgcaag cccataaccg ctgtggcctc ttggttttac agatacgaac ctaaactttc       60

aaaacctgtc agtgattggg ttccgaatcc tcctcctgaa agtggccggg tttaatctgc      120

tcatgacgct gcggctgtgg tccagctgag gtgaggggcc ttgaagctgg gagtggggtt      180

tagggacgcg ggtctctggg tgcatcctaa gctctgagag caaacctccc tgcagggtct      240

tgcttttaag tccaaagcct gagcccacca aactctccta cttcttcctg ttacaaattc      300

ctcttgtgca ataataatgg cctgaaacgc tgtaaaatat cctcatttca gccgcctcag      360

ttgcacttct cccctatgag gtaggaagaa cagttgttta gaaacgaaga aactgaggcc      420

ccacagctaa tgagtggagg aagagagaca cttgtgtaca ccacatgcct tgtgttgtac      480

ttctc                                                                  485


<210>  232
<211>  463
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OMNI75_TRAC_S13 PAM containing genomic seq

<400>  232
cctgggttgg ggcaaagagg gaaatgagat catgtcctaa ccctgatcct cttgtcccac       60

agatatccag aaccctgacc ctgccgtgta ccagctgaga gactctaaat ccagtgacaa      120

gtctgtctgc ctattcaccg attttgattc tcaaacaaat gtgtcacaaa gtaaggattc      180

tgatgtgtat atcacagaca aaactgtgct agacatgagg tctatggact tcaagagcaa      240

cagtgctgtg gcctggagca acaaatctga ctttgcatgt gcaaacgcct tcaacaacag      300

cattattcca gaagacacct tcttccccag cccaggtaag ggcagctttg gtgccttcgc      360

aggctgtttc cttgcttcag gaatggccag gttctgccca gagctctggt caatgatgtc      420

taaaactcct ctgattggtg gtctcggcct tatccattgc cac                        463


<210>  233
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T1

<400>  233
ggtgcggttc accagggtgt cg                                                22


<210>  234
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2

<400>  234
ggaagagcag agccttggtc tc                                                22


