                         SEQUENCE LISTING

<110>  Prelude Corporation
       University of Bergen
       Strell, Carina
       Ostman, Carl A
       Stenmark Tullberg , Axel E
       Holmberg, Erik C.V.
       Karlsson, Per  O
       Malmstrom, Per-Olof
       Ferno, Lars M
 
<120>  METHODS FOR TREATING A SUBJECT WITH LOCAL INVASIVE BREAST CANCER 
       BASED ON PDGFRB LEVELS

<130>  PRLUD.009WO

<150>  63/094574
<151>  2020-10-21

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1106
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Leu Pro Gly Ala Met Pro Ala Leu Ala Leu Lys Gly Glu Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Leu Glu Pro Gln Ile Ser Gln Gly 
            20                  25                  30          


Leu Val Val Thr Pro Pro Gly Pro Glu Leu Val Leu Asn Val Ser Ser 
        35                  40                  45              


Thr Phe Val Leu Thr Cys Ser Gly Ser Ala Pro Val Val Trp Glu Arg 
    50                  55                  60                  


Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
65                  70                  75                  80  


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
                85                  90                  95      


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
            100                 105                 110         


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
        115                 120                 125             


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
    130                 135                 140                 


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
145                 150                 155                 160 


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
                165                 170                 175     


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
            180                 185                 190         


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
        195                 200                 205             


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
    210                 215                 220                 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
225                 230                 235                 240 


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
                245                 250                 255     


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
            260                 265                 270         


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
        275                 280                 285             


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
    290                 295                 300                 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
305                 310                 315                 320 


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
                325                 330                 335     


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
            340                 345                 350         


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
        355                 360                 365             


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
    370                 375                 380                 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
385                 390                 395                 400 


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
                405                 410                 415     


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
            420                 425                 430         


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
        435                 440                 445             


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
    450                 455                 460                 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
465                 470                 475                 480 


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
                485                 490                 495     


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
            500                 505                 510         


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
        515                 520                 525             


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
    530                 535                 540                 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
545                 550                 555                 560 


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
                565                 570                 575     


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
            580                 585                 590         


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
        595                 600                 605             


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
    610                 615                 620                 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
625                 630                 635                 640 


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
                645                 650                 655     


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
            660                 665                 670         


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
        675                 680                 685             


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
    690                 695                 700                 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
705                 710                 715                 720 


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
                725                 730                 735     


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
            740                 745                 750         


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
        755                 760                 765             


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
    770                 775                 780                 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
785                 790                 795                 800 


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
                805                 810                 815     


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
            820                 825                 830         


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
        835                 840                 845             


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
    850                 855                 860                 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
865                 870                 875                 880 


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
                885                 890                 895     


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
            900                 905                 910         


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
        915                 920                 925             


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
    930                 935                 940                 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
945                 950                 955                 960 


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
                965                 970                 975     


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
            980                 985                 990         


Pro Gly Phe His Gly Leu Arg Ser  Pro Leu Asp Thr Ser  Ser Val Leu 
        995                 1000                 1005             


Tyr Thr  Ala Val Gln Pro Asn  Glu Gly Asp Asn Asp  Tyr Ile Ile 
    1010                 1015                 1020             


Pro Leu  Pro Asp Pro Lys Pro  Glu Val Ala Asp Glu  Gly Pro Leu 
    1025                 1030                 1035             


Glu Gly  Ser Pro Ser Leu Ala  Ser Ser Thr Leu Asn  Glu Val Asn 
    1040                 1045                 1050             


Thr Ser  Ser Thr Ile Ser Cys  Asp Ser Pro Leu Glu  Pro Gln Asp 
    1055                 1060                 1065             


Glu Pro  Glu Pro Glu Pro Gln  Leu Glu Leu Gln Val  Glu Pro Glu 
    1070                 1075                 1080             


Pro Glu  Leu Glu Gln Leu Pro  Asp Ser Gly Cys Pro  Ala Pro Arg 
    1085                 1090                 1095             


Ala Glu  Ala Glu Asp Ser Phe  Leu 
    1100                 1105     


<210>  2
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Gln Glu Pro Pro Gln Glu Met Ala Lys Ala Gln Asp Gly Thr 
1               5                   10                  15      


Phe Ser Ser Val Leu Thr Leu Thr Asn Leu Thr Gly Leu Asp Thr Gly 
            20                  25                  30          


Glu Tyr Phe Cys Thr His Asn Asp Ser Arg Gly Leu Glu Thr Asp Glu 
        35                  40                  45              


Arg Lys Arg Leu Tyr Ile Phe Val Pro Asp Pro Thr Val Gly Phe Leu 
    50                  55                  60                  


Pro Asn Asp Ala Glu Glu Leu Phe Ile Phe Leu Thr Glu Ile Thr Glu 
65                  70                  75                  80  


Ile Thr Ile Pro Cys Arg Val Thr Asp Pro Gln Leu Val Val Thr Leu 
                85                  90                  95      


His Glu Lys Lys Gly Asp Val Ala Leu Pro Val Pro Tyr Asp His Gln 
            100                 105                 110         


Arg Gly Phe Ser Gly Ile Phe Glu Asp Arg Ser Tyr Ile Cys Lys Thr 
        115                 120                 125             


Thr Ile Gly Asp Arg Glu Val Asp Ser Asp Ala Tyr Tyr Val Tyr Arg 
    130                 135                 140                 


Leu Gln Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val 
145                 150                 155                 160 


Val Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn 
                165                 170                 175     


Glu Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg 
            180                 185                 190         


Leu Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile 
        195                 200                 205             


Arg Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr 
    210                 215                 220                 


Tyr Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys 
225                 230                 235                 240 


Ala Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly 
                245                 250                 255     


Glu Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu 
            260                 265                 270         


Gln Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys 
        275                 280                 285             


Asp Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser 
    290                 295                 300                 


Thr Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val 
305                 310                 315                 320 


Arg Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His 
                325                 330                 335     


Glu Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro 
            340                 345                 350         


Val Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln 
        355                 360                 365             


Thr Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp 
    370                 375                 380                 


Ser Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr 
385                 390                 395                 400 


Leu Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val 
                405                 410                 415     


Thr Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg 
            420                 425                 430         


Leu Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn 
        435                 440                 445             


Ala Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu 
    450                 455                 460                 


Pro Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu 
465                 470                 475                 480 


Thr Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro 
                485                 490                 495     


Arg Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly 
            500                 505                 510         


His Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr 
        515                 520                 525             


Trp Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser 
    530                 535                 540                 


Gly Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His 
545                 550                 555                 560 


Ser Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala 
                565                 570                 575     


Arg Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser 
            580                 585                 590         


His Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr 
        595                 600                 605             


Lys Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp 
    610                 615                 620                 


Leu Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His 
625                 630                 635                 640 


Ser Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu 
                645                 650                 655     


Pro Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser 
            660                 665                 670         


Asp Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val 
        675                 680                 685             


Pro Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser 
    690                 695                 700                 


Ser Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu 
705                 710                 715                 720 


Arg Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr 
                725                 730                 735     


Met Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe 
            740                 745                 750         


Leu Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val 
        755                 760                 765             


Leu Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala 
    770                 775                 780                 


Arg Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe 
785                 790                 795                 800 


Leu Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr 
                805                 810                 815     


Thr Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile 
            820                 825                 830         


Phe Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln 
        835                 840                 845             


Phe Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His 
    850                 855                 860                 


Ala Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys 
865                 870                 875                 880 


Phe Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg 
                885                 890                 895     


Leu Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu 
            900                 905                 910         


Phe Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu 
        915                 920                 925             


Pro Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val Leu 
    930                 935                 940                 


Tyr Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile Pro 
945                 950                 955                 960 


Leu Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu Gly 
                965                 970                 975     


Ser Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser Ser 
            980                 985                 990         


Thr Ile Ser Cys Asp Ser Pro Leu  Glu Pro Gln Asp Glu  Pro Glu Pro 
        995                 1000                 1005             


Glu Pro  Gln Leu Glu Leu Gln  Val Glu Pro Glu Pro  Glu Leu Glu 
    1010                 1015                 1020             


Gln Leu  Pro Asp Ser Gly Cys  Pro Ala Pro Arg Ala  Glu Ala Glu 
    1025                 1030                 1035             


Asp Ser  Phe Leu 
    1040         


<210>  3
<211>  945
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile Thr Asn Val Ala Phe Leu Val Ser Leu Arg Thr Glu Ala Thr 
1               5                   10                  15      


Ser Ala Lys Pro Pro Leu Gly Thr Gly Arg Trp Ile Leu Met Pro Thr 
            20                  25                  30          


Met Ser Thr Asp Ser Arg Val Ser Pro Leu Ser Gly Leu Met Leu Ser 
        35                  40                  45              


Arg Val Ser Ser Ile Asn Val Ser Val Asn Ala Val Gln Thr Val Val 
    50                  55                  60                  


Arg Gln Gly Glu Asn Ile Thr Leu Met Cys Ile Val Ile Gly Asn Glu 
65                  70                  75                  80  


Val Val Asn Phe Glu Trp Thr Tyr Pro Arg Lys Glu Ser Gly Arg Leu 
                85                  90                  95      


Val Glu Pro Val Thr Asp Phe Leu Leu Asp Met Pro Tyr His Ile Arg 
            100                 105                 110         


Ser Ile Leu His Ile Pro Ser Ala Glu Leu Glu Asp Ser Gly Thr Tyr 
        115                 120                 125             


Thr Cys Asn Val Thr Glu Ser Val Asn Asp His Gln Asp Glu Lys Ala 
    130                 135                 140                 


Ile Asn Ile Thr Val Val Glu Ser Gly Tyr Val Arg Leu Leu Gly Glu 
145                 150                 155                 160 


Val Gly Thr Leu Gln Phe Ala Glu Leu His Arg Ser Arg Thr Leu Gln 
                165                 170                 175     


Val Val Phe Glu Ala Tyr Pro Pro Pro Thr Val Leu Trp Phe Lys Asp 
            180                 185                 190         


Asn Arg Thr Leu Gly Asp Ser Ser Ala Gly Glu Ile Ala Leu Ser Thr 
        195                 200                 205             


Arg Asn Val Ser Glu Thr Arg Tyr Val Ser Glu Leu Thr Leu Val Arg 
    210                 215                 220                 


Val Lys Val Ala Glu Ala Gly His Tyr Thr Met Arg Ala Phe His Glu 
225                 230                 235                 240 


Asp Ala Glu Val Gln Leu Ser Phe Gln Leu Gln Ile Asn Val Pro Val 
                245                 250                 255     


Arg Val Leu Glu Leu Ser Glu Ser His Pro Asp Ser Gly Glu Gln Thr 
            260                 265                 270         


Val Arg Cys Arg Gly Arg Gly Met Pro Gln Pro Asn Ile Ile Trp Ser 
        275                 280                 285             


Ala Cys Arg Asp Leu Lys Arg Cys Pro Arg Glu Leu Pro Pro Thr Leu 
    290                 295                 300                 


Leu Gly Asn Ser Ser Glu Glu Glu Ser Gln Leu Glu Thr Asn Val Thr 
305                 310                 315                 320 


Tyr Trp Glu Glu Glu Gln Glu Phe Glu Val Val Ser Thr Leu Arg Leu 
                325                 330                 335     


Gln His Val Asp Arg Pro Leu Ser Val Arg Cys Thr Leu Arg Asn Ala 
            340                 345                 350         


Val Gly Gln Asp Thr Gln Glu Val Ile Val Val Pro His Ser Leu Pro 
        355                 360                 365             


Phe Lys Val Val Val Ile Ser Ala Ile Leu Ala Leu Val Val Leu Thr 
    370                 375                 380                 


Ile Ile Ser Leu Ile Ile Leu Ile Met Leu Trp Gln Lys Lys Pro Arg 
385                 390                 395                 400 


Tyr Glu Ile Arg Trp Lys Val Ile Glu Ser Val Ser Ser Asp Gly His 
                405                 410                 415     


Glu Tyr Ile Tyr Val Asp Pro Met Gln Leu Pro Tyr Asp Ser Thr Trp 
            420                 425                 430         


Glu Leu Pro Arg Asp Gln Leu Val Leu Gly Arg Thr Leu Gly Ser Gly 
        435                 440                 445             


Ala Phe Gly Gln Val Val Glu Ala Thr Ala His Gly Leu Ser His Ser 
    450                 455                 460                 


Gln Ala Thr Met Lys Val Ala Val Lys Met Leu Lys Ser Thr Ala Arg 
465                 470                 475                 480 


Ser Ser Glu Lys Gln Ala Leu Met Ser Glu Leu Lys Ile Met Ser His 
                485                 490                 495     


Leu Gly Pro His Leu Asn Val Val Asn Leu Leu Gly Ala Cys Thr Lys 
            500                 505                 510         


Gly Gly Pro Ile Tyr Ile Ile Thr Glu Tyr Cys Arg Tyr Gly Asp Leu 
        515                 520                 525             


Val Asp Tyr Leu His Arg Asn Lys His Thr Phe Leu Gln His His Ser 
    530                 535                 540                 


Asp Lys Arg Arg Pro Pro Ser Ala Glu Leu Tyr Ser Asn Ala Leu Pro 
545                 550                 555                 560 


Val Gly Leu Pro Leu Pro Ser His Val Ser Leu Thr Gly Glu Ser Asp 
                565                 570                 575     


Gly Gly Tyr Met Asp Met Ser Lys Asp Glu Ser Val Asp Tyr Val Pro 
            580                 585                 590         


Met Leu Asp Met Lys Gly Asp Val Lys Tyr Ala Asp Ile Glu Ser Ser 
        595                 600                 605             


Asn Tyr Met Ala Pro Tyr Asp Asn Tyr Val Pro Ser Ala Pro Glu Arg 
    610                 615                 620                 


Thr Cys Arg Ala Thr Leu Ile Asn Glu Ser Pro Val Leu Ser Tyr Met 
625                 630                 635                 640 


Asp Leu Val Gly Phe Ser Tyr Gln Val Ala Asn Gly Met Glu Phe Leu 
                645                 650                 655     


Ala Ser Lys Asn Cys Val His Arg Asp Leu Ala Ala Arg Asn Val Leu 
            660                 665                 670         


Ile Cys Glu Gly Lys Leu Val Lys Ile Cys Asp Phe Gly Leu Ala Arg 
        675                 680                 685             


Asp Ile Met Arg Asp Ser Asn Tyr Ile Ser Lys Gly Ser Thr Phe Leu 
    690                 695                 700                 


Pro Leu Lys Trp Met Ala Pro Glu Ser Ile Phe Asn Ser Leu Tyr Thr 
705                 710                 715                 720 


Thr Leu Ser Asp Val Trp Ser Phe Gly Ile Leu Leu Trp Glu Ile Phe 
                725                 730                 735     


Thr Leu Gly Gly Thr Pro Tyr Pro Glu Leu Pro Met Asn Glu Gln Phe 
            740                 745                 750         


Tyr Asn Ala Ile Lys Arg Gly Tyr Arg Met Ala Gln Pro Ala His Ala 
        755                 760                 765             


Ser Asp Glu Ile Tyr Glu Ile Met Gln Lys Cys Trp Glu Glu Lys Phe 
    770                 775                 780                 


Glu Ile Arg Pro Pro Phe Ser Gln Leu Val Leu Leu Leu Glu Arg Leu 
785                 790                 795                 800 


Leu Gly Glu Gly Tyr Lys Lys Lys Tyr Gln Gln Val Asp Glu Glu Phe 
                805                 810                 815     


Leu Arg Ser Asp His Pro Ala Ile Leu Arg Ser Gln Ala Arg Leu Pro 
            820                 825                 830         


Gly Phe His Gly Leu Arg Ser Pro Leu Asp Thr Ser Ser Val Leu Tyr 
        835                 840                 845             


Thr Ala Val Gln Pro Asn Glu Gly Asp Asn Asp Tyr Ile Ile Pro Leu 
    850                 855                 860                 


Pro Asp Pro Lys Pro Glu Val Ala Asp Glu Gly Pro Leu Glu Gly Ser 
865                 870                 875                 880 


Pro Ser Leu Ala Ser Ser Thr Leu Asn Glu Val Asn Thr Ser Ser Thr 
                885                 890                 895     


Ile Ser Cys Asp Ser Pro Leu Glu Pro Gln Asp Glu Pro Glu Pro Glu 
            900                 905                 910         


Pro Gln Leu Glu Leu Gln Val Glu Leu Glu Pro Glu Thr Glu Leu Leu 
        915                 920                 925             


Ile Asp Ser Gly Cys Pro Ala Pro Arg Ala Glu Ala Glu Asp Ser Phe 
    930                 935                 940                 


Leu 
945 


<210>  4
<211>  5700
<212>  RNA
<213>  Homo sapiens

<400>  4
agcagccagc agugacugcc cgcccuaucu gggacccagg aucgcucugu gagcaacuug       60

gagccagaga ggagaucaac aaggaggagg agagagccgg ccccucagcc cugcugccca      120

gcagcagccu gugcucgccc ugcccaacgc agacagccag acccagggcg gccccucugg      180

cggcucugcu ccucccgaag gaugcuuggg gagugaggcg aagcugggcc gcuccucucc      240

ccuacagcag cccccuuccu ccaucccucu guucuccuga gccuucagga gccugcacca      300

guccugccug uccuucuacu cagcuguuac ccacucuggg accagcaguc uuucugauaa      360

cugggagagg gcaguaagga ggacuuccug gaggggguga cuguccagag ccuggaacug      420

ugcccacacc agaagccauc agcagcaagg acaccaugcg gcuuccgggu gcgaugccag      480

cucuggcccu caaaggcgag cugcuguugc ugucucuccu guuacuucug gaaccacaga      540

ucucucaggg ccuggucguc acacccccgg ggccagagcu uguccucaau gucuccagca      600

ccuucguucu gaccugcucg gguucagcuc cgguggugug ggaacggaug ucccaggagc      660

ccccacagga aauggccaag gcccaggaug gcaccuucuc cagcgugcuc acacugacca      720

accucacugg gcuagacacg ggagaauacu uuugcaccca caaugacucc cguggacugg      780

agaccgauga gcggaaacgg cucuacaucu uugugccaga ucccaccgug ggcuuccucc      840

cuaaugaugc cgaggaacua uucaucuuuc ucacggaaau aacugagauc accauuccau      900

gccgaguaac agacccacag cuggugguga cacugcacga gaagaaaggg gacguugcac      960

ugccuguccc cuaugaucac caacguggcu uuucugguau cuuugaggac agaagcuaca     1020

ucugcaaaac caccauuggg gacagggagg uggauucuga ugccuacuau gucuacagac     1080

uccagguguc auccaucaac gucucuguga acgcagugca gacugugguc cgccagggug     1140

agaacaucac ccucaugugc auugugaucg ggaaugaggu ggucaacuuc gaguggacau     1200

acccccgcaa agaaaguggg cggcuggugg agccggugac ugacuuccuc uuggauaugc     1260

cuuaccacau ccgcuccauc cugcacaucc ccagugccga guuagaagac ucggggaccu     1320

acaccugcaa ugugacggag agugugaaug accaucagga ugaaaaggcc aucaacauca     1380

ccgugguuga gagcggcuac gugcggcucc ugggagaggu gggcacacua caauuugcug     1440

agcugcaucg gagccggaca cugcagguag uguucgaggc cuacccaccg cccacugucc     1500

ugugguucaa agacaaccgc acccugggcg acuccagcgc uggcgaaauc gcccugucca     1560

cgcgcaacgu gucggagacc cgguaugugu cagagcugac acugguucgc gugaaggugg     1620

cagaggcugg ccacuacacc augcgggccu uccaugagga ugcugagguc cagcucuccu     1680

uccagcuaca gaucaauguc ccuguccgag ugcuggagcu aagugagagc cacccugaca     1740

guggggaaca gacaguccgc ugucguggcc ggggcaugcc ccagccgaac aucaucuggu     1800

cugccugcag agaccucaaa agguguccac gugagcugcc gcccacgcug cuggggaaca     1860

guuccgaaga ggagagccag cuggagacua acgugacgua cugggaggag gagcaggagu     1920

uugagguggu gagcacacug cgucugcagc acguggaucg gccacugucg gugcgcugca     1980

cgcugcgcaa cgcugugggc caggacacgc aggaggucau cguggugcca cacuccuugc     2040

ccuuuaaggu gguggugauc ucagccaucc uggcccuggu ggugcucacc aucaucuccc     2100

uuaucauccu caucaugcuu uggcagaaga agccacguua cgagauccga uggaagguga     2160

uugagucugu gagcucugac ggccaugagu acaucuacgu ggaccccaug cagcugcccu     2220

augacuccac gugggagcug ccgcgggacc agcuugugcu gggacgcacc cucggcucug     2280

gggccuuugg gcagguggug gaggccacgg cucauggccu gagccauucu caggccacga     2340

ugaaaguggc cgucaagaug cuuaaaucca cagcccgcag cagugagaag caagcccuua     2400

ugucggagcu gaagaucaug agucaccuug ggccccaccu gaacgugguc aaccuguugg     2460

gggccugcac caaaggagga cccaucuaua ucaucacuga guacugccgc uacggagacc     2520

ugguggacua ccugcaccgc aacaaacaca ccuuccugca gcaccacucc gacaagcgcc     2580

gcccgcccag cgcggagcuc uacagcaaug cucugcccgu ugggcucccc cugcccagcc     2640

auguguccuu gaccggggag agcgacggug gcuacaugga caugagcaag gacgagucgg     2700

uggacuaugu gcccaugcug gacaugaaag gagacgucaa auaugcagac aucgaguccu     2760

ccaacuacau ggccccuuac gauaacuacg uucccucugc cccugagagg accugccgag     2820

caacuuugau caacgagucu ccagugcuaa gcuacaugga ccucgugggc uucagcuacc     2880

agguggccaa uggcauggag uuucuggccu ccaagaacug cguccacaga gaccuggcgg     2940

cuaggaacgu gcucaucugu gaaggcaagc uggucaagau cugugacuuu ggccuggcuc     3000

gagacaucau gcgggacucg aauuacaucu ccaaaggcag caccuuuuug ccuuuaaagu     3060

ggauggcucc ggagagcauc uucaacagcc ucuacaccac ccugagcgac gugugguccu     3120

ucgggauccu gcucugggag aucuucaccu uggguggcac cccuuaccca gagcugccca     3180

ugaacgagca guucuacaau gccaucaaac gggguuaccg cauggcccag ccugcccaug     3240

ccuccgacga gaucuaugag aucaugcaga agugcuggga agagaaguuu gagauucggc     3300

cccccuucuc ccagcuggug cugcuucucg agagacuguu gggcgaaggu uacaaaaaga     3360

aguaccagca gguggaugag gaguuucuga ggagugacca cccagccauc cuucgguccc     3420

aggcccgcuu gccuggguuc cauggccucc gaucuccccu ggacaccagc uccguccucu     3480

auacugccgu gcagcccaau gagggugaca acgacuauau caucccccug ccugacccca     3540

aacccgaggu ugcugacgag ggcccacugg aggguucccc cagccuagcc agcuccaccc     3600

ugaaugaagu caacaccucc ucaaccaucu ccugugacag cccccuggag ccccaggacg     3660

aaccagagcc agagccccag cuugagcucc agguggagcc ggagccagag cuggaacagu     3720

ugccggauuc ggggugcccu gcgccucggg cggaagcaga ggauagcuuc cuguaggggg     3780

cuggccccua cccugcccug ccugaagcuc ccccccugcc agcacccagc aucuccuggc     3840

cuggccugac cgggcuuccu gucagccagg cugcccuuau cagcuguccc cuucuggaag     3900

cuuucugcuc cugacguguu gugccccaaa cccuggggcu ggcuuaggag gcaagaaaac     3960

ugcaggggcc gugaccagcc cucugccucc agggaggcca acugacucug agccaggguu     4020

cccccaggga acucaguuuu cccauaugua aaaugggaaa guuaggcuug augacccaga     4080

aucuaggauu cucucccugg cugacaggug gggagaccga aucccucccu gggaagauuc     4140

uuggaguuac ugagguggua aauuaacuuu uuucuguuca gccagcuacc ccucaaggaa     4200

ucauagcucu cuccucgcac uuuuauccac ccaggagcua gggaagagac ccuagccucc     4260

cuggcugcug gcugagcuag ggccuagccu ugagcagugu ugccucaucc agaagaaagc     4320

cagucuccuc ccuaugaugc cagucccugc guucccuggc ccgagcuggu cuggggccau     4380

uaggcagccu aauuaaugcu ggaggcugag ccaaguacag gacaccccca gccugcagcc     4440

cuugcccagg gcacuuggag cacacgcagc cauagcaagu gccugugucc cuguccuuca     4500

ggcccaucag uccuggggcu uuuucuuuau cacccucagu cuuaauccau ccaccagagu     4560

cuagaaggcc agacgggccc cgcaucugug augagaaugu aaaugugcca guguggagug     4620

gccacgugug ugugccagua uauggcccug gcucugcauu ggaccugcua ugaggcuuug     4680

gaggaauccc ucacccucuc ugggccucag uuuccccuuc aaaaaaugaa uaagucggac     4740

uuauuaacuc ugagugccuu gccagcacua acauucuaga guauuccagg ugguugcaca     4800

uuuguccaga ugaagcaagg ccauauaccc uaaacuucca uccugggggu cagcugggcu     4860

ccugggagau uccagaucac acaucacacu cuggggacuc aggaaccaug ccccuucccc     4920

aggcccccag caagucucaa gaacacagcu gcacaggccu ugacuuagag ugacagccgg     4980

uguccuggaa agcccccagc agcugcccca gggacauggg aagaccacgg gaccucuuuc     5040

acuacccacg augaccuccg gggguauccu gggcaaaagg gacaaagagg gcaaaugaga     5100

ucaccuccug cagcccacca cuccagcacc ugugccgagg ucugcgucga agacagaaug     5160

gacagugagg acaguuaugu cuuguaaaag acaagaagcu ucagaugggu accccaagaa     5220

ggaugugaga ggugggcgcu uuggagguuu gccccucacc caccagcugc cccaucccug     5280

aggcagcgcu ccaugggggu augguuuugu cacugcccag accuagcagu gacaucucau     5340

uguccccagc ccagugggca uuggaggugc caggggaguc aggguuguag ccaagacgcc     5400

cccgcacggg gaggguuggg aagggggugc aggaagcuca accccucugg gcaccaaccc     5460

ugcauugcag guuggcaccu uacuucccug ggauccccag aguuggucca aggagggaga     5520

guggguucuc aauacgguac caaagauaua aucaccuagg uuuacaaaua uuuuuaggac     5580

ucacguuaac ucacauuuau acagcagaaa ugcuauuuug uaugcuguug aguuuuucua     5640

ucuguguacu uuuuuuuaag ggaaagauuu uaauauuaaa ccuggugcuu cucacucaca     5700


<210>  5
<211>  5654
<212>  RNA
<213>  Homo sapiens

<400>  5
agcagccagc agugacugcc cgcccuaucu gggacccagg aucgcucugu gagcaacuug       60

gagccagaga ggagaucaac aaggaggagg agagagccgg ccccucagcc cugcugccca      120

gcagcagccu gugcucgccc ugcccaacgc agacagccag acccagggcg gccccucugg      180

cggcucugcu ccucccgaag gaugcuuggg gagugaggcg aagcugggcc gcuccucucc      240

ccuacagcag cccccuuccu ccaucccucu guucuccuga gccuucagga gccugcacca      300

guccugccug uccuucuacu cagcuguuac ccacucuggg accagcaguc uuucugauaa      360

cugggagagg gcaguaagga ggacuuccug gaggggguga cuguccagag ccuggaacug      420

ugcccacacc agaagccauc agcagcaagg cgagcugcug uugcugucuc uccuguuacu      480

ucuggaacca cagaucucuc agggccuggu cgucacaccc ccggggccag agcuuguccu      540

caaugucucc agcaccuucg uucugaccug cucggguuca gcuccggugg ugugggaacg      600

gaugucccag gagcccccac aggaaauggc caaggcccag gauggcaccu ucuccagcgu      660

gcucacacug accaaccuca cugggcuaga cacgggagaa uacuuuugca cccacaauga      720

cucccgugga cuggagaccg augagcggaa acggcucuac aucuuugugc cagaucccac      780

cgugggcuuc cucccuaaug augccgagga acuauucauc uuucucacgg aaauaacuga      840

gaucaccauu ccaugccgag uaacagaccc acagcuggug gugacacugc acgagaagaa      900

aggggacguu gcacugccug uccccuauga ucaccaacgu ggcuuuucug guaucuuuga      960

ggacagaagc uacaucugca aaaccaccau uggggacagg gagguggauu cugaugccua     1020

cuaugucuac agacuccagg ugucauccau caacgucucu gugaacgcag ugcagacugu     1080

gguccgccag ggugagaaca ucacccucau gugcauugug aucgggaaug agguggucaa     1140

cuucgagugg acauaccccc gcaaagaaag ugggcggcug guggagccgg ugacugacuu     1200

ccucuuggau augccuuacc acauccgcuc cauccugcac auccccagug ccgaguuaga     1260

agacucgggg accuacaccu gcaaugugac ggagagugug aaugaccauc aggaugaaaa     1320

ggccaucaac aucaccgugg uugagagcgg cuacgugcgg cuccugggag aggugggcac     1380

acuacaauuu gcugagcugc aucggagccg gacacugcag guaguguucg aggccuaccc     1440

accgcccacu guccuguggu ucaaagacaa ccgcacccug ggcgacucca gcgcuggcga     1500

aaucgcccug uccacgcgca acgugucgga gacccgguau gugucagagc ugacacuggu     1560

ucgcgugaag guggcagagg cuggccacua caccaugcgg gccuuccaug aggaugcuga     1620

gguccagcuc uccuuccagc uacagaucaa ugucccuguc cgagugcugg agcuaaguga     1680

gagccacccu gacagugggg aacagacagu ccgcugucgu ggccggggca ugccccagcc     1740

gaacaucauc uggucugccu gcagagaccu caaaaggugu ccacgugagc ugccgcccac     1800

gcugcugggg aacaguuccg aagaggagag ccagcuggag acuaacguga cguacuggga     1860

ggaggagcag gaguuugagg uggugagcac acugcgucug cagcacgugg aucggccacu     1920

gucggugcgc ugcacgcugc gcaacgcugu gggccaggac acgcaggagg ucaucguggu     1980

gccacacucc uugcccuuua aggugguggu gaucucagcc auccuggccc ugguggugcu     2040

caccaucauc ucccuuauca uccucaucau gcuuuggcag aagaagccac guuacgagau     2100

ccgauggaag gugauugagu cugugagcuc ugacggccau gaguacaucu acguggaccc     2160

caugcagcug cccuaugacu ccacguggga gcugccgcgg gaccagcuug ugcugggacg     2220

cacccucggc ucuggggccu uugggcaggu gguggaggcc acggcucaug gccugagcca     2280

uucucaggcc acgaugaaag uggccgucaa gaugcuuaaa uccacagccc gcagcaguga     2340

gaagcaagcc cuuaugucgg agcugaagau caugagucac cuugggcccc accugaacgu     2400

ggucaaccug uugggggccu gcaccaaagg aggacccauc uauaucauca cugaguacug     2460

ccgcuacgga gaccuggugg acuaccugca ccgcaacaaa cacaccuucc ugcagcacca     2520

cuccgacaag cgccgcccgc ccagcgcgga gcucuacagc aaugcucugc ccguugggcu     2580

cccccugccc agccaugugu ccuugaccgg ggagagcgac gguggcuaca uggacaugag     2640

caaggacgag ucgguggacu augugcccau gcuggacaug aaaggagacg ucaaauaugc     2700

agacaucgag uccuccaacu acauggcccc uuacgauaac uacguucccu cugccccuga     2760

gaggaccugc cgagcaacuu ugaucaacga gucuccagug cuaagcuaca uggaccucgu     2820

gggcuucagc uaccaggugg ccaauggcau ggaguuucug gccuccaaga acugcgucca     2880

cagagaccug gcggcuagga acgugcucau cugugaaggc aagcugguca agaucuguga     2940

cuuuggccug gcucgagaca ucaugcggga cucgaauuac aucuccaaag gcagcaccuu     3000

uuugccuuua aaguggaugg cuccggagag caucuucaac agccucuaca ccacccugag     3060

cgacgugugg uccuucggga uccugcucug ggagaucuuc accuugggug gcaccccuua     3120

cccagagcug cccaugaacg agcaguucua caaugccauc aaacgggguu accgcauggc     3180

ccagccugcc caugccuccg acgagaucua ugagaucaug cagaagugcu gggaagagaa     3240

guuugagauu cggccccccu ucucccagcu ggugcugcuu cucgagagac uguugggcga     3300

agguuacaaa aagaaguacc agcaggugga ugaggaguuu cugaggagug accacccagc     3360

cauccuucgg ucccaggccc gcuugccugg guuccauggc cuccgaucuc cccuggacac     3420

cagcuccguc cucuauacug ccgugcagcc caaugagggu gacaacgacu auaucauccc     3480

ccugccugac cccaaacccg agguugcuga cgagggccca cuggaggguu cccccagccu     3540

agccagcucc acccugaaug aagucaacac cuccucaacc aucuccugug acagcccccu     3600

ggagccccag gacgaaccag agccagagcc ccagcuugag cuccaggugg agccggagcc     3660

agagcuggaa caguugccgg auucggggug cccugcgccu cgggcggaag cagaggauag     3720

cuuccuguag ggggcuggcc ccuacccugc ccugccugaa gcuccccccc ugccagcacc     3780

cagcaucucc uggccuggcc ugaccgggcu uccugucagc caggcugccc uuaucagcug     3840

uccccuucug gaagcuuucu gcuccugacg uguugugccc caaacccugg ggcuggcuua     3900

ggaggcaaga aaacugcagg ggccgugacc agcccucugc cuccagggag gccaacugac     3960

ucugagccag gguuccccca gggaacucag uuuucccaua uguaaaaugg gaaaguuagg     4020

cuugaugacc cagaaucuag gauucucucc cuggcugaca gguggggaga ccgaaucccu     4080

cccugggaag auucuuggag uuacugaggu gguaaauuaa cuuuuuucug uucagccagc     4140

uaccccucaa ggaaucauag cucucuccuc gcacuuuuau ccacccagga gcuagggaag     4200

agacccuagc cucccuggcu gcuggcugag cuagggccua gccuugagca guguugccuc     4260

auccagaaga aagccagucu ccucccuaug augccagucc cugcguuccc uggcccgagc     4320

uggucugggg ccauuaggca gccuaauuaa ugcuggaggc ugagccaagu acaggacacc     4380

cccagccugc agcccuugcc cagggcacuu ggagcacacg cagccauagc aagugccugu     4440

gucccugucc uucaggccca ucaguccugg ggcuuuuucu uuaucacccu cagucuuaau     4500

ccauccacca gagucuagaa ggccagacgg gccccgcauc ugugaugaga auguaaaugu     4560

gccagugugg aguggccacg ugugugugcc aguauauggc ccuggcucug cauuggaccu     4620

gcuaugaggc uuuggaggaa ucccucaccc ucucugggcc ucaguuuccc cuucaaaaaa     4680

ugaauaaguc ggacuuauua acucugagug ccuugccagc acuaacauuc uagaguauuc     4740

caggugguug cacauuuguc cagaugaagc aaggccauau acccuaaacu uccauccugg     4800

gggucagcug ggcuccuggg agauuccaga ucacacauca cacucugggg acucaggaac     4860

caugccccuu ccccaggccc ccagcaaguc ucaagaacac agcugcacag gccuugacuu     4920

agagugacag ccgguguccu ggaaagcccc cagcagcugc cccagggaca ugggaagacc     4980

acgggaccuc uuucacuacc cacgaugacc uccgggggua uccugggcaa aagggacaaa     5040

gagggcaaau gagaucaccu ccugcagccc accacuccag caccugugcc gaggucugcg     5100

ucgaagacag aauggacagu gaggacaguu augucuugua aaagacaaga agcuucagau     5160

ggguacccca agaaggaugu gagagguggg cgcuuuggag guuugccccu cacccaccag     5220

cugccccauc ccugaggcag cgcuccaugg ggguaugguu uugucacugc ccagaccuag     5280

cagugacauc ucauuguccc cagcccagug ggcauuggag gugccagggg agucaggguu     5340

guagccaaga cgcccccgca cggggagggu ugggaagggg gugcaggaag cucaaccccu     5400

cugggcacca acccugcauu gcagguuggc accuuacuuc ccugggaucc ccagaguugg     5460

uccaaggagg gagagugggu ucucaauacg guaccaaaga uauaaucacc uagguuuaca     5520

aauauuuuua ggacucacgu uaacucacau uuauacagca gaaaugcuau uuuguaugcu     5580

guugaguuuu ucuaucugug uacuuuuuuu uaagggaaag auuuuaauau uaaaccuggu     5640

gcuucucacu caca                                                       5654


<210>  6
<211>  5734
<212>  RNA
<213>  Homo sapiens

<400>  6
agcagccagc agugacugcc cgcccuaucu gggacccagg aucgcucugu gagcaacuug       60

gagccagaga ggagaucaac aaggaggagg agagagccgg ccccucagcc cugcugccca      120

gcagcagccu gugcucgccc ugcccaacgc agacagccag acccagggcg gccccucugg      180

cggcucugcu ccucccgaag gaugcuuggg gagugaggcg aagcugggcc gcuccucucc      240

ccuacagcag cccccuuccu ccaucccucu guucuccuga gccuucagga gccugcacca      300

guccugccug uccuucuacu cagcuguuac ccacucuggg accagcaguc uuucugauaa      360

cugggagagg gcaguaagga ggacuuccug gaggggguga cuguccagag ccuggaacug      420

ugcccacacc agaagccauc agcagcaagg acaccaugcg gcuuccgggu gcgaugccag      480

cucuggcccu caaaggcgag cugcuguugc ugucucuccu guuacuucug gaaccacaga      540

ucucucaggg ccuggucguc acacccccgg ggccagagcu uguccucaau gucuccagca      600

ccuucguucu gaccugcucg gguucagcuc cgguggugug ggaacggaug ucccaggagc      660

ccccacagga aauggccaag gcccaggaug gcaccuucuc cagcgugcuc acacugacca      720

accucacugg gcuagacacg ggagaauacu uuugcaccca caaugacucc cguggacugg      780

agaccgauga gcggaaacgg cucuacaucu uugugccaga ucccaccgug ggcuuccucc      840

cuaaugaugc cgaggaacua uucaucuuuc ucacggaaau aacugagauc accauuccau      900

gccgaguaac agacccacag cuggugguga cacugcacga gaagaaaggg gacguugcac      960

ugccuguccc cuaugaucac caacguggcu uuucugguau cuuugaggac agaagcuaca     1020

ucugcaaaac caccauuggg gacagggagg uggauucuga ugccuacuau gucuacagac     1080

uccaggguga gcccccuuuc uggccugaug cucagcagag ugucauccau caacgucucu     1140

gugaacgcag ugcagacugu gguccgccag ggugagaaca ucacccucau gugcauugug     1200

aucgggaaug agguggucaa cuucgagugg acauaccccc gcaaagaaag ugggcggcug     1260

guggagccgg ugacugacuu ccucuuggau augccuuacc acauccgcuc cauccugcac     1320

auccccagug ccgaguuaga agacucgggg accuacaccu gcaaugugac ggagagugug     1380

aaugaccauc aggaugaaaa ggccaucaac aucaccgugg uugagagcgg cuacgugcgg     1440

cuccugggag aggugggcac acuacaauuu gcugagcugc aucggagccg gacacugcag     1500

guaguguucg aggccuaccc accgcccacu guccuguggu ucaaagacaa ccgcacccug     1560

ggcgacucca gcgcuggcga aaucgcccug uccacgcgca acgugucgga gacccgguau     1620

gugucagagc ugacacuggu ucgcgugaag guggcagagg cuggccacua caccaugcgg     1680

gccuuccaug aggaugcuga gguccagcuc uccuuccagc uacagaucaa ugucccuguc     1740

cgagugcugg agcuaaguga gagccacccu gacagugggg aacagacagu ccgcugucgu     1800

ggccggggca ugccccagcc gaacaucauc uggucugccu gcagagaccu caaaaggugu     1860

ccacgugagc ugccgcccac gcugcugggg aacaguuccg aagaggagag ccagcuggag     1920

acuaacguga cguacuggga ggaggagcag gaguuugagg uggugagcac acugcgucug     1980

cagcacgugg aucggccacu gucggugcgc ugcacgcugc gcaacgcugu gggccaggac     2040

acgcaggagg ucaucguggu gccacacucc uugcccuuua aggugguggu gaucucagcc     2100

auccuggccc ugguggugcu caccaucauc ucccuuauca uccucaucau gcuuuggcag     2160

aagaagccac guuacgagau ccgauggaag gugauugagu cugugagcuc ugacggccau     2220

gaguacaucu acguggaccc caugcagcug cccuaugacu ccacguggga gcugccgcgg     2280

gaccagcuug ugcugggacg cacccucggc ucuggggccu uugggcaggu gguggaggcc     2340

acggcucaug gccugagcca uucucaggcc acgaugaaag uggccgucaa gaugcuuaaa     2400

uccacagccc gcagcaguga gaagcaagcc cuuaugucgg agcugaagau caugagucac     2460

cuugggcccc accugaacgu ggucaaccug uugggggccu gcaccaaagg aggacccauc     2520

uauaucauca cugaguacug ccgcuacgga gaccuggugg acuaccugca ccgcaacaaa     2580

cacaccuucc ugcagcacca cuccgacaag cgccgcccgc ccagcgcgga gcucuacagc     2640

aaugcucugc ccguugggcu cccccugccc agccaugugu ccuugaccgg ggagagcgac     2700

gguggcuaca uggacaugag caaggacgag ucgguggacu augugcccau gcuggacaug     2760

aaaggagacg ucaaauaugc agacaucgag uccuccaacu acauggcccc uuacgauaac     2820

uacguucccu cugccccuga gaggaccugc cgagcaacuu ugaucaacga gucuccagug     2880

cuaagcuaca uggaccucgu gggcuucagc uaccaggugg ccaauggcau ggaguuucug     2940

gccuccaaga acugcgucca cagagaccug gcggcuagga acgugcucau cugugaaggc     3000

aagcugguca agaucuguga cuuuggccug gcucgagaca ucaugcggga cucgaauuac     3060

aucuccaaag gcagcaccuu uuugccuuua aaguggaugg cuccggagag caucuucaac     3120

agccucuaca ccacccugag cgacgugugg uccuucggga uccugcucug ggagaucuuc     3180

accuugggug gcaccccuua cccagagcug cccaugaacg agcaguucua caaugccauc     3240

aaacgggguu accgcauggc ccagccugcc caugccuccg acgagaucua ugagaucaug     3300

cagaagugcu gggaagagaa guuugagauu cggccccccu ucucccagcu ggugcugcuu     3360

cucgagagac uguugggcga agguuacaaa aagaaguacc agcaggugga ugaggaguuu     3420

cugaggagug accacccagc cauccuucgg ucccaggccc gcuugccugg guuccauggc     3480

cuccgaucuc cccuggacac cagcuccguc cucuauacug ccgugcagcc caaugagggu     3540

gacaacgacu auaucauccc ccugccugac cccaaacccg agguugcuga cgagggccca     3600

cuggaggguu cccccagccu agccagcucc acccugaaug aagucaacac cuccucaacc     3660

aucuccugug acagcccccu ggagccccag gacgaaccag agccagagcc ccagcuugag     3720

cuccaggugg agccggagcc agagcuggaa caguugccgg auucggggug cccugcgccu     3780

cgggcggaag cagaggauag cuuccuguag ggggcuggcc ccuacccugc ccugccugaa     3840

gcuccccccc ugccagcacc cagcaucucc uggccuggcc ugaccgggcu uccugucagc     3900

caggcugccc uuaucagcug uccccuucug gaagcuuucu gcuccugacg uguugugccc     3960

caaacccugg ggcuggcuua ggaggcaaga aaacugcagg ggccgugacc agcccucugc     4020

cuccagggag gccaacugac ucugagccag gguuccccca gggaacucag uuuucccaua     4080

uguaaaaugg gaaaguuagg cuugaugacc cagaaucuag gauucucucc cuggcugaca     4140

gguggggaga ccgaaucccu cccugggaag auucuuggag uuacugaggu gguaaauuaa     4200

cuuuuuucug uucagccagc uaccccucaa ggaaucauag cucucuccuc gcacuuuuau     4260

ccacccagga gcuagggaag agacccuagc cucccuggcu gcuggcugag cuagggccua     4320

gccuugagca guguugccuc auccagaaga aagccagucu ccucccuaug augccagucc     4380

cugcguuccc uggcccgagc uggucugggg ccauuaggca gccuaauuaa ugcuggaggc     4440

ugagccaagu acaggacacc cccagccugc agcccuugcc cagggcacuu ggagcacacg     4500

cagccauagc aagugccugu gucccugucc uucaggccca ucaguccugg ggcuuuuucu     4560

uuaucacccu cagucuuaau ccauccacca gagucuagaa ggccagacgg gccccgcauc     4620

ugugaugaga auguaaaugu gccagugugg aguggccacg ugugugugcc aguauauggc     4680

ccuggcucug cauuggaccu gcuaugaggc uuuggaggaa ucccucaccc ucucugggcc     4740

ucaguuuccc cuucaaaaaa ugaauaaguc ggacuuauua acucugagug ccuugccagc     4800

acuaacauuc uagaguauuc caggugguug cacauuuguc cagaugaagc aaggccauau     4860

acccuaaacu uccauccugg gggucagcug ggcuccuggg agauuccaga ucacacauca     4920

cacucugggg acucaggaac caugccccuu ccccaggccc ccagcaaguc ucaagaacac     4980

agcugcacag gccuugacuu agagugacag ccgguguccu ggaaagcccc cagcagcugc     5040

cccagggaca ugggaagacc acgggaccuc uuucacuacc cacgaugacc uccgggggua     5100

uccugggcaa aagggacaaa gagggcaaau gagaucaccu ccugcagccc accacuccag     5160

caccugugcc gaggucugcg ucgaagacag aauggacagu gaggacaguu augucuugua     5220

aaagacaaga agcuucagau ggguacccca agaaggaugu gagagguggg cgcuuuggag     5280

guuugccccu cacccaccag cugccccauc ccugaggcag cgcuccaugg ggguaugguu     5340

uugucacugc ccagaccuag cagugacauc ucauuguccc cagcccagug ggcauuggag     5400

gugccagggg agucaggguu guagccaaga cgcccccgca cggggagggu ugggaagggg     5460

gugcaggaag cucaaccccu cugggcacca acccugcauu gcagguuggc accuuacuuc     5520

ccugggaucc ccagaguugg uccaaggagg gagagugggu ucucaauacg guaccaaaga     5580

uauaaucacc uagguuuaca aauauuuuua ggacucacgu uaacucacau uuauacagca     5640

gaaaugcuau uuuguaugcu guugaguuuu ucuaucugug uacuuuuuuu uaagggaaag     5700

auuuuaauau uaaaccuggu gcuucucacu caca                                 5734


