                         SEQUENCE LISTING

<110>  The Board of Regents of the University of Texas System
       Wu, Jun
       Yu, Leqian
 
<120>  METHODS FOR GENERATING FORMATIVE PLURIPOTENT STEM CELLS

<130>  106546-703050 (UTSD 3709-PCT)

<150>  63/093,680
<151>  2020-10-19

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  6774
<212>  DNA
<213>  Homo sapiens

<400>  1
cggccccaga aaacccgagc gagtaggggg cggcgcgcag gagggaggag aactgggggc       60

gcgggaggct ggtgggtgtg gggggtggag atgtagaaga tgtgacgccg cggcccggcg      120

ggtgccagat tagcggacgc ggtgcccgcg gttgcaacgg gatcccgggc gctgcagctt      180

gggaggcggc tctccccagg cggcgtccgc ggagacaccc atccgtgaac cccaggtccc      240

gggccgccgg ctcgccgcgc accaggggcc ggcggacaga agagcggccg agcggctcga      300

ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg ggccggggcc      360

ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg gcggctcccc      420

gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg gcagccggga      480

gcatcaccac gctgcccgcc ttgcccgagg atggcggcag cggcgccttc ccgcccggcc      540

acttcaagga ccccaagcgg ctgtactgca aaaacggggg cttcttcctg cgcatccacc      600

ccgacggccg agttgacggg gtccgggaga agagcgaccc tcacatcaag ctacaacttc      660

aagcagaaga gagaggagtt gtgtctatca aaggagtgtg tgctaaccgt tacctggcta      720

tgaaggaaga tggaagatta ctggcttcta aatgtgttac ggatgagtgt ttcttttttg      780

aacgattgga atctaataac tacaatactt accggtcaag gaaatacacc agttggtatg      840

tggcactgaa acgaactggg cagtataaac ttggatccaa aacaggacct gggcagaaag      900

ctatactttt tcttccaatg tctgctaaga gctgatttta atggccacat ctaatctcat      960

ttcacatgaa agaagaagta tattttagaa atttgttaat gagagtaaaa gaaaataaat     1020

gtgtatagct cagtttggat aattggtcaa acaatttttt atccagtagt aaaatatgta     1080

accattgtcc cagtaaagaa aaataacaaa agttgtaaaa tgtatattct cccttttata     1140

ttgcatctgc tgttacccag tgaagcttac ctagagcaat gatctttttc acgcatttgc     1200

tttattcgaa aagaggcttt taaaatgtgc atgtttagaa acaaaatttc ttcatggaaa     1260

tcatatacat tagaaaatca cagtcagatg tttaatcaat ccaaaatgtc cactatttct     1320

tatgtcattc gttagtctac atgtttctaa acatataaat gtgaatttaa tcaattcctt     1380

tcatagtttt ataattctct ggcagttcct tatgatagag tttataaaac agtcctgtgt     1440

aaactgctgg aagttcttcc acagtcaggt caattttgtc aaacccttct ctgtacccat     1500

acagcagcag cctagcaact ctgctggtga tgggagttgt attttcagtc ttcgccaggt     1560

cattgagatc catccactca catcttaagc attcttcctg gcaaaaattt atggtgaatg     1620

aatatggctt taggcggcag atgatataca tatctgactt cccaaaagct ccaggatttg     1680

tgtgctgttg ccgaatactc aggacggacc tgaattctga ttttatacca gtctcttcaa     1740

aaacttctcg aaccgctgtg tctcctacgt aaaaaaagag atgtacaaat caataataat     1800

tacactttta gaaactgtat catcaaagat tttcagttaa agtagcatta tgtaaaggct     1860

caaaacatta ccctaacaaa gtaaagtttt caatacaaat tctttgcctt gtggatatca     1920

agaaatccca aaatattttc ttaccactgt aaattcaaga agcttttgaa atgctgaata     1980

tttctttggc tgctacttgg aggcttatct acctgtacat ttttggggtc agctcttttt     2040

aacttcttgc tgctcttttt cccaaaaggt aaaaatatag attgaaaagt taaaacattt     2100

tgcatggctg cagttccttt gtttcttgag ataagattcc aaagaactta gattcatttc     2160

ttcaacaccg aaatgctgga ggtgtttgat cagttttcaa gaaacttgga atataaataa     2220

ttttataatt caacaaaggt tttcacattt tataaggttg atttttcaat taaatgcaaa     2280

tttgtgtggc aggattttta ttgccattaa catatttttg tggctgcttt ttctacacat     2340

ccagatggtc cctctaactg ggctttctct aattttgtga tgttctgtca ttgtctccca     2400

aagtatttag gagaagccct ttaaaaagct gccttcctct accactttgc tggaaagctt     2460

cacaattgtc acagacaaag atttttgttc caatactcgt tttgcctcta tttttcttgt     2520

ttgtcaaata gtaaatgata tttgcccttg cagtaattct actggtgaaa aacatgcaaa     2580

gaagaggaag tcacagaaac atgtctcaat tcccatgtgc tgtgactgta gactgtctta     2640

ccatagactg tcttacccat cccctggata tgctcttgtt ttttccctct aatagctatg     2700

gaaagatgca tagaaagagt ataatgtttt aaaacataag gcattcgtct gccatttttc     2760

aattacatgc tgacttccct tacaattgag atttgcccat aggttaaaca tggttagaaa     2820

caactgaaag cataaaagaa aaatctaggc cgggtgcagt ggctcatgcc tatattccct     2880

gcactttggg aggccaaagc aggaggatcg cttgagccca ggagttcaag accaacctgg     2940

tgaaaccccg tctctacaaa aaaacacaaa aaatagccag gcatggtggc gtgtacatgt     3000

ggtctcagat acttgggagg ctgaggtggg agggttgatc acttgaggct gagaggtcaa     3060

ggttgcagtg agccataatc gtgccactgc agtccagcct aggcaacaga gtgagacttt     3120

gtctcaaaaa aagagaaatt ttccttaata agaaaagtaa tttttactct gatgtgcaat     3180

acatttgtta ttaaatttat tatttaagat ggtagcacta gtcttaaatt gtataaaata     3240

tcccctaaca tgtttaaatg tccattttta ttcattatgc tttgaaaaat aattatgggg     3300

aaatacatgt ttgttattaa atttattatt aaagatagta gcactagtct taaatttgat     3360

ataacatctc ctaacttgtt taaatgtcca tttttattct ttatgtttga aaataaatta     3420

tggggatcct atttagctct tagtaccact aatcaaaagt tcggcatgta gctcatgatc     3480

tatgctgttt ctatgtcgtg gaagcaccgg atgggggtag tgagcaaatc tgccctgctc     3540

agcagtcacc atagcagctg actgaaaatc agcactgcct gagtagtttt gatcagttta     3600

acttgaatca ctaactgact gaaaattgaa tgggcaaata agtgcttttg tctccagagt     3660

atgcgggaga cccttccacc tcaagatgga tatttcttcc ccaaggattt caagatgaat     3720

tgaaattttt aatcaagata gtgtgcttta ttctgttgta ttttttatta ttttaatata     3780

ctgtaagcca aactgaaata acatttgctg ttttataggt ttgaagaaca taggaaaaac     3840

taagaggttt tgtttttatt tttgctgatg aagagatatg tttaaatatg ttgtattgtt     3900

ttgtttagtt acaggacaat aatgaaatgg agtttatatt tgttatttct attttgttat     3960

atttaataat agaattagat tgaaataaaa tataatggga aataatctgc agaatgtggg     4020

ttttcctggt gtttccctct gactctagtg cactgatgat ctctgataag gctcagctgc     4080

tttatagttc tctggctaat gcagcagata ctcttcctgc cagtggtaat acgatttttt     4140

aagaaggcag tttgtcaatt ttaatcttgt ggataccttt atactcttag ggtattattt     4200

tatacaaaag ccttgaggat tgcattctat tttctatatg accctcttga tatttaaaaa     4260

acactatgga taacaattct tcatttacct agtattatga aagaatgaag gagttcaaac     4320

aaatgtgttt cccagttaac tagggtttac tgtttgagcc aatataaatg tttaactgtt     4380

tgtgatggca gtattcctaa agtacattgc atgttttcct aaatacagag tttaaataat     4440

ttcagtaatt cttagatgat tcagcttcat cattaagaat atcttttgtt ttatgttgag     4500

ttagaaatgc cttcatatag acatagtctt tcagacctct actgtcagtt ttcatttcta     4560

gctgctttca gggttttatg aattttcagg caaagcttta atttatacta agcttaggaa     4620

gtatggctaa tgccaacggc agtttttttc ttcttaattc cacatgactg aggcatatat     4680

gatctctggg taggtgagtt gttgtgacaa ccacaagcac tttttttttt tttaaagaaa     4740

aaaaggtagt gaatttttaa tcatctggac tttaagaagg attctggagt atacttaggc     4800

ctgaaattat atatatttgg cttggaaatg tgtttttctt caattacatc tacaagtaag     4860

tacagctgaa attcagagga cccataagag ttcacatgaa aaaaatcaat ttatttgaaa     4920

aggcaagatg caggagagag gaagccttgc aaacctgcag actgcttttt gcccaatata     4980

gattgggtaa ggctgcaaaa cataagctta attagctcac atgctctgct ctcacgtggc     5040

accagtggat agtgtgagag aattaggctg tagaacaaat ggccttctct ttcagcattc     5100

acaccactac aaaatcatct tttatatcaa cagaagaata agcataaact aagcaaaagg     5160

tcaataagta cctgaaacca agattggcta gagatatatc ttaatgcaat ccattttctg     5220

atggattgtt acgagttggc tatataatgt atgtatggta ttttgatttg tgtaaaagtt     5280

ttaaaaatca agctttaagt acatggacat ttttaaataa aatatttaaa gacaatttag     5340

aaaattgcct taatatcatt gttggctaaa tagaataggg gacatgcata ttaaggaaaa     5400

ggtcatggag aaataatatt ggtatcaaac aaatacattg atttgtcatg atacacattg     5460

aatttgatcc aatagtttaa ggaataggta ggaaaatttg gtttctattt ttcgatttcc     5520

tgtaaatcag tgacataaat aattcttagc ttattttata tttccttgtc ttaaatactg     5580

agctcagtaa gttgtgttag gggattattt ctcagttgag actttcttat atgacatttt     5640

actatgtttt gacttcctga ctattaaaaa taaatagtag atacaatttt cataaagtga     5700

agaattatat aatcactgct ttataactga ctttattata tttatttcaa agttcattta     5760

aaggctacta ttcatcctct gtgatggaat ggtcaggaat ttgttttctc atagtttaat     5820

tccaacaaca atattagtcg tatccaaaat aacctttaat gctaaacttt actgatgtat     5880

atccaaagct tctcattttc agacagatta atccagaagc agtcataaac agaagaatag     5940

gtggtatgtt cctaatgata ttatttctac taatggaata aactgtaata ttagaaatta     6000

tgctgctaat tatatcagct ctgaggtaat ttctgaaatg ttcagactca gtcggaacaa     6060

attggaaaat ttaaattttt attcttagct ataaagcaag aaagtaaaca cattaatttc     6120

ctcaacattt ttaagccaat taaaaatata aaagatacac accaatatct tcttcaggct     6180

ctgacaggcc tcctggaaac ttccacatat ttttcaactg cagtataaag tcagaaaata     6240

aagttaacat aactttcact aacacacaca tatgtagatt tcacaaaatc cacctataat     6300

tggtcaaagt ggttgagaat atatttttta gtaattgcat gcaaaatttt tctagcttcc     6360

atcctttctc cctcgtttct tctttttttg ggggagctgg taactgatga aatcttttcc     6420

caccttttct cttcaggaaa tataagtggt tttgtttggt taacgtgata cattctgtat     6480

gaatgaaaca ttggagggaa acatctactg aatttctgta atttaaaata ttttgctgct     6540

agttaactat gaacagatag aagaatctta cagatgctgc tataaataag tagaaaatat     6600

aaatttcatc actaaaatat gctattttaa aatctatttc ctatattgta tttctaatca     6660

gatgtattac tcttattatt tctattgtat gtgttaatga ttttatgtaa aaatgtaatt     6720

gcttttcatg agtagtatga ataaaattga ttagtttgtg ttttcttgtc tccc           6774


<210>  2
<211>  288
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Gly Val Gly Gly Gly Asp Val Glu Asp Val Thr Pro Arg Pro 
1               5                   10                  15      


Gly Gly Cys Gln Ile Ser Gly Arg Gly Ala Arg Gly Cys Asn Gly Ile 
            20                  25                  30          


Pro Gly Ala Ala Ala Trp Glu Ala Ala Leu Pro Arg Arg Arg Pro Arg 
        35                  40                  45              


Arg His Pro Ser Val Asn Pro Arg Ser Arg Ala Ala Gly Ser Pro Arg 
    50                  55                  60                  


Thr Arg Gly Arg Arg Thr Glu Glu Arg Pro Ser Gly Ser Arg Leu Gly 
65                  70                  75                  80  


Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly Gly Arg 
                85                  90                  95      


Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro 
        115                 120                 125             


Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ile Thr Thr Leu Pro Ala 
    130                 135                 140                 


Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His Phe Lys 
145                 150                 155                 160 


Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu Arg Ile 
                165                 170                 175     


His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp Pro His 
            180                 185                 190         


Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser Ile Lys 
        195                 200                 205             


Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly Arg Leu 
    210                 215                 220                 


Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu Arg Leu 
225                 230                 235                 240 


Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr Ser Trp 
                245                 250                 255     


Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr 
            260                 265                 270         


Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala Lys Ser 
        275                 280                 285             


<210>  3
<211>  4704
<212>  DNA
<213>  Homo sapiens

<400>  3
ggagagggag aaggctctcg ggcggagaga ggtcctgccc agctgttggc gaggagtttc       60

ctgtttcccc cgcagcgctg agttgaagtt gagtgagtca ctcgcgcgca cggagcgacg      120

acacccccgc gcgtgcaccc gctcgggaca ggagccggac tcctgtgcag cttccctcgg      180

ccgccggggg cctccccgcg cctcgccggc ctccaggccc cctcctggct ggcgagcggg      240

cgccacatct ggcccgcaca tctgcgctgc cggcccggcg cggggtccgg agagggcgcg      300

gcgcggaggc gcagccaggg gtccgggaag gcgccgtccg ctgcgctggg ggctcggtct      360

atgacgagca gcggggtctg ccatgggtcg ggggctgctc aggggcctgt ggccgctgca      420

catcgtcctg tggacgcgta tcgccagcac gatcccaccg cacgttcaga agtcggatgt      480

ggaaatggag gcccagaaag atgaaatcat ctgccccagc tgtaatagga ctgcccatcc      540

actgagacat attaataacg acatgatagt cactgacaac aacggtgcag tcaagtttcc      600

acaactgtgt aaattttgtg atgtgagatt ttccacctgt gacaaccaga aatcctgcat      660

gagcaactgc agcatcacct ccatctgtga gaagccacag gaagtctgtg tggctgtatg      720

gagaaagaat gacgagaaca taacactaga gacagtttgc catgacccca agctccccta      780

ccatgacttt attctggaag atgctgcttc tccaaagtgc attatgaagg aaaaaaaaaa      840

gcctggtgag actttcttca tgtgttcctg tagctctgat gagtgcaatg acaacatcat      900

cttctcagaa gaatataaca ccagcaatcc tgacttgttg ctagtcatat ttcaagtgac      960

aggcatcagc ctcctgccac cactgggagt tgccatatct gtcatcatca tcttctactg     1020

ctaccgcgtt aaccggcagc agaagctgag ttcaacctgg gaaaccggca agacgcggaa     1080

gctcatggag ttcagcgagc actgtgccat catcctggaa gatgaccgct ctgacatcag     1140

ctccacgtgt gccaacaaca tcaaccacaa cacagagctg ctgcccattg agctggacac     1200

cctggtgggg aaaggtcgct ttgctgaggt ctataaggcc aagctgaagc agaacacttc     1260

agagcagttt gagacagtgg cagtcaagat ctttccctat gaggagtatg cctcttggaa     1320

gacagagaag gacatcttct cagacatcaa tctgaagcat gagaacatac tccagttcct     1380

gacggctgag gagcggaaga cggagttggg gaaacaatac tggctgatca ccgccttcca     1440

cgccaagggc aacctacagg agtacctgac gcggcatgtc atcagctggg aggacctgcg     1500

caagctgggc agctccctcg cccgggggat tgctcacctc cacagtgatc acactccatg     1560

tgggaggccc aagatgccca tcgtgcacag ggacctcaag agctccaata tcctcgtgaa     1620

gaacgaccta acctgctgcc tgtgtgactt tgggctttcc ctgcgtctgg accctactct     1680

gtctgtggat gacctggcta acagtgggca ggtgggaact gcaagataca tggctccaga     1740

agtcctagaa tccaggatga atttggagaa tgttgagtcc ttcaagcaga ccgatgtcta     1800

ctccatggct ctggtgctct gggaaatgac atctcgctgt aatgcagtgg gagaagtaaa     1860

agattatgag cctccatttg gttccaaggt gcgggagcac ccctgtgtcg aaagcatgaa     1920

ggacaacgtg ttgagagatc gagggcgacc agaaattccc agcttctggc tcaaccacca     1980

gggcatccag atggtgtgtg agacgttgac tgagtgctgg gaccacgacc cagaggcccg     2040

tctcacagcc cagtgtgtgg cagaacgctt cagtgagctg gagcatctgg acaggctctc     2100

ggggaggagc tgctcggagg agaagattcc tgaagacggc tccctaaaca ctaccaaata     2160

gctcttctgg ggcaggctgg gccatgtcca aagaggctgc ccctctcacc aaagaacaga     2220

ggcagcagga agctgcccct gaactgatgc ttcctggaaa accaaggggg tcactcccct     2280

ccctgtaagc tgtggggata agcagaaaca acagcagcag ggagtgggtg acatagagca     2340

ttctatgcct ttgacattgt cataggataa gctgtgttag cacttcctca ggaaatgaga     2400

ttgattttta caatagccaa taacatttgc actttattaa tgcctgtata taaatatgaa     2460

tagctatgtt ttatatatat atatatatat ctatatatgt ctatagctct atatatatag     2520

ccataccttg aaaagagaca aggaaaaaca tcaaatattc ccaggaaatt ggttttattg     2580

gagaactcca gaaccaagca gagaaggaag ggacccatga cagcattagc atttgacaat     2640

cacacatgca gtggttctct gactgtaaaa cagtgaactt tgcatgagga aagaggctcc     2700

atgtctcaca gccagctatg accacattgc acttgctttt gcaaaataat cattccctgc     2760

ctagcacttc tcttctggcc atggaactaa gtacagtggc actgtttgag gaccagtgtt     2820

cccggggttc ctgtgtgccc ttatttctcc tggacttttc atttaagctc caagccccaa     2880

atctgggggg ctagtttaga aactctccct caacctagtt tagaaactct accccatctt     2940

taataccttg aatgttttga accccacttt ttaccttcat gggttgcaga aaaatcagaa     3000

cagatgtccc catccatgcg attgccccac catctactaa tgaaaaattg ttcttttttt     3060

catctttccc ctgcacttat gttactattc tctgctccca gccttcatcc ttttctaaaa     3120

aggagcaaat tctcactcta ggctttatcg tgtttacttt ttcattacac ttgacttgat     3180

tttctagttt tctatacaaa caccaatggg ttccatcttt ctgggctcct gattgctcaa     3240

gcacagtttg gcctgatgaa gaggatttca actacacaat actatcattg tcaggactat     3300

gacctcaggc actctaaaca tatgttttgt ttggtcagca cagcgtttca aaaagtgaag     3360

ccactttata aatatttgga gattttgcag gaaaatctgg atccccaggt aaggatagca     3420

gatggttttc agttatctcc agtccacgtt cacaaaatgt gaaggtgtgg agacacttac     3480

aaagctgcct cacttctcac tgtaaacatt agctctttcc actgcctacc tggaccccag     3540

tctaggaatt aaatctgcac ctaaccaagg tcccttgtaa gaaatgtcca ttcaagcagt     3600

cattctctgg gtatataata tgattttgac taccttatct ggtgttaaga tttgaagttg     3660

gccttttatt ggactaaagg ggaactcctt taagggtctc agttagccca agtttctttt     3720

gcttatatgt taatagtttt accctctgca ttggagagag gagtgcttta ctccaagaag     3780

ctttcctcat ggttaccgtt ctctccatca tgccagcctt ctcaaccttt gcagaaatta     3840

ctagagagga tttgaatgtg ggacacaaag gtcccatttg cagttagaaa atttgtgtcc     3900

acaaggacaa gaacaaagta tgagctttaa aactccatag gaaacttgtt aatcaacaaa     3960

gaagtgttaa tgctgcaagt aatctctttt ttaaaacttt ttgaagctac ttattttcag     4020

ccaaatagga atattagaga gggactggta gtgagaatat cagctctgtt tggatggtgg     4080

aaggtctcat tttattgaga tttttaagat acatgcaaag gtttggaaat agaacctcta     4140

ggcaccctcc tcagtgtggg tgggctgaga gttaaagaca gtgtggctgc agtagcatag     4200

aggcgcctag aaattccact tgcaccgtag ggcatgctga taccatccca atagctgttg     4260

cccattgacc tctagtggtg agtttctaga atactggtcc attcatgaga tattcaagat     4320

tcaagagtat tctcacttct gggttatcag cataaactgg aatgtagtgt cagaggatac     4380

tgtggcttgt tttgtttatg tttttttttc ttattcaaga aaaaagacca aggaataaca     4440

ttctgtagtt cctaaaaata ctgacttttt tcactactat acataaaggg aaagttttat     4500

tcttttatgg aacacttcag ctgtactcat gtattaaaat aggaatgtga atgctatata     4560

ctctttttat atcaaaagtc tcaagcactt atttttattc tatgcattgt ttgtctttta     4620

cataaataaa atgtttatta gattgaataa agcaaaatac tcaggtgagc atcctgcctc     4680

ctgttcccat tcctagtagc taaa                                            4704


<210>  4
<211>  592
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Arg Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu 
1               5                   10                  15      


Trp Thr Arg Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Asp 
            20                  25                  30          


Val Glu Met Glu Ala Gln Lys Asp Glu Ile Ile Cys Pro Ser Cys Asn 
        35                  40                  45              


Arg Thr Ala His Pro Leu Arg His Ile Asn Asn Asp Met Ile Val Thr 
    50                  55                  60                  


Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp 
65                  70                  75                  80  


Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys 
                85                  90                  95      


Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val 
            100                 105                 110         


Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp 
        115                 120                 125             


Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro 
    130                 135                 140                 


Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met 
145                 150                 155                 160 


Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu 
                165                 170                 175     


Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val Ile Phe Gln Val 
            180                 185                 190         


Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala Ile Ser Val Ile 
        195                 200                 205             


Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln Gln Lys Leu Ser Ser 
    210                 215                 220                 


Thr Trp Glu Thr Gly Lys Thr Arg Lys Leu Met Glu Phe Ser Glu His 
225                 230                 235                 240 


Cys Ala Ile Ile Leu Glu Asp Asp Arg Ser Asp Ile Ser Ser Thr Cys 
                245                 250                 255     


Ala Asn Asn Ile Asn His Asn Thr Glu Leu Leu Pro Ile Glu Leu Asp 
            260                 265                 270         


Thr Leu Val Gly Lys Gly Arg Phe Ala Glu Val Tyr Lys Ala Lys Leu 
        275                 280                 285             


Lys Gln Asn Thr Ser Glu Gln Phe Glu Thr Val Ala Val Lys Ile Phe 
    290                 295                 300                 


Pro Tyr Glu Glu Tyr Ala Ser Trp Lys Thr Glu Lys Asp Ile Phe Ser 
305                 310                 315                 320 


Asp Ile Asn Leu Lys His Glu Asn Ile Leu Gln Phe Leu Thr Ala Glu 
                325                 330                 335     


Glu Arg Lys Thr Glu Leu Gly Lys Gln Tyr Trp Leu Ile Thr Ala Phe 
            340                 345                 350         


His Ala Lys Gly Asn Leu Gln Glu Tyr Leu Thr Arg His Val Ile Ser 
        355                 360                 365             


Trp Glu Asp Leu Arg Lys Leu Gly Ser Ser Leu Ala Arg Gly Ile Ala 
    370                 375                 380                 


His Leu His Ser Asp His Thr Pro Cys Gly Arg Pro Lys Met Pro Ile 
385                 390                 395                 400 


Val His Arg Asp Leu Lys Ser Ser Asn Ile Leu Val Lys Asn Asp Leu 
                405                 410                 415     


Thr Cys Cys Leu Cys Asp Phe Gly Leu Ser Leu Arg Leu Asp Pro Thr 
            420                 425                 430         


Leu Ser Val Asp Asp Leu Ala Asn Ser Gly Gln Val Gly Thr Ala Arg 
        435                 440                 445             


Tyr Met Ala Pro Glu Val Leu Glu Ser Arg Met Asn Leu Glu Asn Val 
    450                 455                 460                 


Glu Ser Phe Lys Gln Thr Asp Val Tyr Ser Met Ala Leu Val Leu Trp 
465                 470                 475                 480 


Glu Met Thr Ser Arg Cys Asn Ala Val Gly Glu Val Lys Asp Tyr Glu 
                485                 490                 495     


Pro Pro Phe Gly Ser Lys Val Arg Glu His Pro Cys Val Glu Ser Met 
            500                 505                 510         


Lys Asp Asn Val Leu Arg Asp Arg Gly Arg Pro Glu Ile Pro Ser Phe 
        515                 520                 525             


Trp Leu Asn His Gln Gly Ile Gln Met Val Cys Glu Thr Leu Thr Glu 
    530                 535                 540                 


Cys Trp Asp His Asp Pro Glu Ala Arg Leu Thr Ala Gln Cys Val Ala 
545                 550                 555                 560 


Glu Arg Phe Ser Glu Leu Glu His Leu Asp Arg Leu Ser Gly Arg Ser 
                565                 570                 575     


Cys Ser Glu Glu Lys Ile Pro Glu Asp Gly Ser Leu Asn Thr Thr Lys 
            580                 585                 590         


<210>  5
<211>  6105
<212>  DNA
<213>  Homo sapiens

<400>  5
agtacagtat aaaacttcac agtgccaata ccatgaagag gagctcagac agctcttacc       60

acatgataca agagccggct ggtggaagag tggggaccag aaagagaatt tgctgaagag      120

gagaaggaaa aaaaaaacac caaaaaaaaa aataaaaaaa tccacacaca caaaaaaacc      180

tgcgcgtgag gggggaggaa aagcagggcc ttttaaaaag gcaatcacaa caacttttgc      240

tgccaggatg cccttgcttt ggctgagagg atttctgttg gcaagttgct ggattatagt      300

gaggagttcc cccaccccag gatccgaggg gcacagcgcg gcccccgact gtccgtcctg      360

tgcgctggcc gccctcccaa aggatgtacc caactctcag ccagagatgg tggaggccgt      420

caagaagcac attttaaaca tgctgcactt gaagaagaga cccgatgtca cccagccggt      480

acccaaggcg gcgcttctga acgcgatcag aaagcttcat gtgggcaaag tcggggagaa      540

cgggtatgtg gagatagagg atgacattgg aaggagggca gaaatgaatg aacttatgga      600

gcagacctcg gagatcatca cgtttgccga gtcaggaaca gccaggaaga cgctgcactt      660

cgagatttcc aaggaaggca gtgacctgtc agtggtggag cgtgcagaag tctggctctt      720

cctaaaagtc cccaaggcca acaggaccag gaccaaagtc accatccgcc tcttccagca      780

gcagaagcac ccgcagggca gcttggacac aggggaagag gccgaggaag tgggcttaaa      840

gggggagagg agtgaactgt tgctctctga aaaagtagta gacgctcgga agagcacctg      900

gcatgtcttc cctgtctcca gcagcatcca gcggttgctg gaccagggca agagctccct      960

ggacgttcgg attgcctgtg agcagtgcca ggagagtggc gccagcttgg ttctcctggg     1020

caagaagaag aagaaagaag aggaggggga agggaaaaag aagggcggag gtgaaggtgg     1080

ggcaggagca gatgaggaaa aggagcagtc gcacagacct ttcctcatgc tgcaggcccg     1140

gcagtctgaa gaccaccctc atcgccggcg tcggcggggc ttggagtgtg atggcaaggt     1200

caacatctgc tgtaagaaac agttctttgt cagtttcaag gacatcggct ggaatgactg     1260

gatcattgct ccctctggct atcatgccaa ctactgcgag ggtgagtgcc cgagccatat     1320

agcaggcacg tccgggtcct cactgtcctt ccactcaaca gtcatcaacc actaccgcat     1380

gcggggccat agcccctttg ccaacctcaa atcgtgctgt gtgcccacca agctgagacc     1440

catgtccatg ttgtactatg atgatggtca aaacatcatc aaaaaggaca ttcagaacat     1500

gatcgtggag gagtgtgggt gctcatagag ttgcccagcc cagggggaaa gggagcaaga     1560

gttgtccaga gaagacagtg gcaaaatgaa gaaattttta aggtttctga gttaaccaga     1620

aaaatagaaa ttaaaaacaa aacaaaaaaa aaaacaaaaa aaaacaaaag taaattaaaa     1680

acaaaacctg atgaaacaga tgaaggaaga tgtggaaaaa atccttagcc agggctcaga     1740

gatgaagcag tgaaagagac aggaattggg agggaaaggg agaatggtgt accctttatt     1800

tcttctgaaa tcacactgat gacatcagtt gtttaaacgg ggtattgtcc tttcccccct     1860

tgaggttccc ttgtgagcct tgaatcaacc aatctagtct gcagtagtgt ggactagaac     1920

aacccaaata gcatctagaa agccatgagt ttgaaagggc ccatcacagg cactttccta     1980

cccaattacc caggtcataa ggtatgtctg tgtgacactt atctctgtgt atatcagcat     2040

acacacacac acacacacac acacacacac acacaggcat ttccacacat tacatatata     2100

cacatactgg taaaagaaca atcgtgtgca ggtggtcaca cttccttttt ctgtaccact     2160

tttgcaacaa aacaaaacaa acaacattaa aaaattgaga acaagtatgg aaagaatgaa     2220

agatcaagga aaaaagaata ccaagttaca tttcgttaag gtgcttatga tcttagaact     2280

atgcaaccta ataggtttga aactgtttac ctgagagaga acaaaaagag agactttttt     2340

gtattggaag taatctgatt aatttttatt ttcttcaagg agagatactt gaaaggaata     2400

tgtttgtcca tctgttggat ccaaacattt ctatattttg taaatgttgt tgttgttttt     2460

tttttaatcg tttactattt gcactacaat ggtgtttgac ctgtctaatc cttatttaac     2520

aagtattttc tttggttggg ggtgggggtg gggtttaaga gctgcactta atgtgagcta     2580

taaaagaact gctacagcac acaaaatagc tatttttatt attataatta taattattat     2640

tattattttg taccttaaaa aatagacaca tacaccaaag acatttgtgt gagcctttaa     2700

acagtctgtc tgtggttggt atcattcacc atcaatgagt caggggttgg gattcaaggt     2760

tgagtagtgt ggattgtgtt caggcttaaa agacctgaga agtttggttt ttgactcctt     2820

ttacatccat gaaacaggac atttcatact ggatgtacag tagttgtaca ctgttggata     2880

tcaagttcaa tcaaattcat ggaactacat gcttgtatgt gtatatatac attgcttgtg     2940

catatgcata tctgtatgta tatatacatg tattgtacca tgtccataca cattttaagc     3000

acttcaggct gtcatttttt aatgttctta aagcaatgaa tgtttgtgtg caaaacacag     3060

tatttttaag aaggataggc tatagttttt gcttttactc tgaactaggt gggcgcattt     3120

caaaaattcg gatgggaaaa agcctggaaa ttccagtgaa tattcagcaa ggccctcttt     3180

cattgtacag ggatcaaatt tcctcctctt ttttgtgccc cctcccactt ctacaagtta     3240

tcccctgtgg ggaaaacagg atgataatca aaactctggg ctgatgtttt tccaacttag     3300

tgtctattgg aatcaatctt aaatcagaag ctttttcaga aaaataatat ttaggccaga     3360

attagagttg agtgtatttt ttaaaaatga ttaaggcttg gttgtgagaa atattacctg     3420

taccagctgg gaaaaataat gtcatcacta actaaaagat aattaatttg agagaaagtg     3480

ttaagagagg gagagtaagg aagagaacag ttaagaggag gcagaggtga gggcagtagt     3540

aaaaatctct aaaattttaa tttacagcca aaattcttca tgtgtaaatt tgtattgatt     3600

cagatgcaga aatgaaaaaa aaacaccttt gttttataaa tatcaaagta catgcttaaa     3660

gccaagtttt tatctagttt attctagtac ttagcttgcc tggaatagct aataaattat     3720

tcatgtatgt gcttttgaaa atccagagcc ctatttttac acacttgtgt gaagttggca     3780

aacattttga aaaatggaaa aaagtttcta ataattggga acaattacat taattaatat     3840

tttgtaaaat attgaagctt ttagccctat gtcaatttgt agattaaaat aaattaatta     3900

taggaaagga agataacagt gagaaaccaa acattacaaa aggtggttta gctctccttg     3960

aaaaatatac taagttggta tactataaca cttggctata tgtaggcaat gtcactactg     4020

ggcaaataca cttactgtgt tctagaggca gccctttctt atgcagaaaa tacaatacgc     4080

actgcatgag aagcttgaga gtggattcta atccaggtct gtcgaccttg gatatcatgc     4140

atgtgggaag gtgggtgtgg tgagaaaagt tttaaggcaa gagtagatgg ccatgttcaa     4200

ctttacaaaa tttcttggaa aactggcagt attttgaact gcatcttctt tggtaccgga     4260

acctgcagaa acagtgtgag aaattaagtc ctggttcact gcgcagtagc aaagatggtc     4320

aaggccatgg aaaaagcaga aatttaccaa gaaagctgat acccatgtat agttcccact     4380

catctcaaat acatctgcta tctttttaag ctaagtccta gacatatcgg ggataacatg     4440

ggggttgatt agtgaccaca gttatcagaa gcagagaaat gtaattccat attttatttg     4500

aaacttattc catattttaa ttggatattg agtgattggg ttatcaaaca cccacaaact     4560

ttaattttgt taaatttata tggctttgaa atagaagtat aagttgctac cattttttga     4620

taacattgaa agatagtatt ttaccatctt taatcatctt ggaaaataca agtcctgtga     4680

acaaccactc tttcacctag cagcatgagg ccaaaagtaa aggctttaaa ttataacata     4740

tgggattctt agtagtatgt ttttttcttg aaactcagtg gctctatcta accttactat     4800

ctcctcactc tttctctaag actaaactct aggctcttaa aaatctgccc acaccaatct     4860

tagaagctct gaaaagaatt tgtctttaaa tatcttttaa tagtaacatg tattttatgg     4920

accaaattga cattttcgac tattttttcc aaaaaagtca ggtgaatttc agcacactga     4980

gttgggaatt tcttatccca gaagaccaac caatttcata tttatttaag attgattcca     5040

tactccgttt tcaaggagaa tccctgcagt ctccttaaag gtagaacaaa tactttctat     5100

ttttttttca ccattgtggg attggacttt aagaggtgac tctaaaaaaa cagagaacaa     5160

atatgtctca gttgtattaa gcacggaccc atattatcat attcacttaa aaaaatgatt     5220

tcctgtgcac cttttggcaa cttctctttt caatgtaggg aaaaacttag tcaccctgaa     5280

aacccacaaa ataaataaaa cttgtagatg tgggcagaag gtttgggggt ggacattgta     5340

tgtgtttaaa ttaaaccctg tatcactgag aagctgttgt atgggtcaga gaaaatgaat     5400

gcttagaagc tgttcacatc ttcaagagca gaagcaaacc acatgtctca gctatattat     5460

tatttatttt ttatgcataa agtgaatcat ttcttctgta ttaatttcca aagggtttta     5520

ccctctattt aaatgctttg aaaaacagtg cattgacaat gggttgatat ttttctttaa     5580

aagaaaaata taattatgaa agccaagata atctgaagcc tgttttattt taaaactttt     5640

tatgttctgt ggttgatgtt gtttgtttgt ttgtttctat tttgttggtt ttttactttg     5700

ttttttgttt tgttttgttt tgttttgcat actacatgca gttctttaac caatgtctgt     5760

ttggctaatg taattaaagt tgttaattta tatgagtgca tttcaactat gtcaatggtt     5820

tcttaatatt tattgtgtag aagtactggt aattttttta tttacaatat gtttaaagag     5880

ataacagttt gatatgtttt catgtgttta tagcagaagt tatttatttc tatggcattc     5940

cagcggatat tttggtgttt gcgaggcatg cagtcaatat tttgtacagt tagtggacag     6000

tattcagcaa cgcctgatag cttctttggc cttatgttaa ataaaaagac ctgtttggga     6060

tgtaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa                     6105


<210>  6
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  7
<211>  2988
<212>  DNA
<213>  Homo sapiens

<400>  7
gcaggagggc ccagcgacgc cgccgcgcca gctcccaggg cccggccccc cccggcgctc       60

acgctctcgg ggcggactcc cggccctccg cgccctctcg cgcggcgatg gccccactcg      120

gatacttctt actcctctgc agcctgaagc aggctctggg cagctacccg atctggtggt      180

cgctggctgt tgggccacag tattcctccc tgggctcgca gcccatcctg tgtgccagca      240

tcccgggcct ggtccccaag cagctccgct tctgcaggaa ctacgtggag atcatgccca      300

gcgtggccga gggcatcaag attggcatcc aggagtgcca gcaccagttc cgcggccgcc      360

ggtggaactg caccaccgtc cacgacagcc tggccatctt cgggcccgtg ctggacaaag      420

ctaccaggga gtcggccttt gtccacgcca ttgcctcagc cggtgtggcc tttgcagtga      480

cacgctcatg tgcagaaggc acggccgcca tctgtggctg cagcagccgc caccagggct      540

caccaggcaa gggctggaag tggggtggct gtagcgagga catcgagttt ggtgggatgg      600

tgtctcggga gttcgccgac gcccgggaga accggccaga tgcccgctca gccatgaacc      660

gccacaacaa cgaggctggg cgccaggcca tcgccagcca catgcacctc aagtgcaagt      720

gccacgggct gtcgggcagc tgcgaggtga agacatgctg gtggtcgcaa cccgacttcc      780

gcgccatcgg tgacttcctc aaggacaagt acgacagcgc ctcggagatg gtggtggaga      840

agcaccggga gtcccgcggc tgggtggaga ccctgcggcc gcgctacacc tacttcaagg      900

tgcccacgga gcgcgacctg gtctactacg aggcctcgcc caacttctgc gagcccaacc      960

ctgagacggg ctccttcggc acgcgcgacc gcacctgcaa cgtcagctcg cacggcatcg     1020

acggctgcga cctgctgtgc tgcggccgcg gccacaacgc gcgagcggag cggcgccggg     1080

agaagtgccg ctgcgtgttc cactggtgct gctacgtcag ctgccaggag tgcacgcgcg     1140

tctacgacgt gcacacctgc aagtaggcac cggccgcggc tccccctgga cggggcgggc     1200

cctgcctgag ggtgggcttt tccctgggtg gagcaggact cccacctaaa cggggcagta     1260

ctcctccctg ggggcgggac tcctccctgg gggtggggct cctacctggg ggcagaactc     1320

ctacctgaag gcagggctcc tccctggagc tagtgtctcc tctctggtgg ctgggctgct     1380

cctgaatgag gcggagctcc aggatgggga ggggctctgc gttggcttct ccctggggac     1440

ggggctcccc tggacagagg cggggctaca gattgggcgg ggcttctctt gggtgggaca     1500

gggcttctcc tgcgggggcg aggcccctcc cagtaagggc gtggctctgg gtgggcgggg     1560

cactaggtag gcttctacct gcaggcgggg ctcctcctga aggaggcggg gctctaggat     1620

ggggcacggc tctggggtag gctgctccct gagggcggag cgcctcctta ggagtggggt     1680

tttatggtgg atgaggcttc ttcctggatg gggcagagct tctcctgacc agggcaaggc     1740

cccttccacg ggggctgtgg ctctgggtgg gcgtggcctg cataggctcc ttcctgtggg     1800

tggggcttct ctgggaccag gctccaatgg ggcggggctt ctctccgcgg gtgggactct     1860

tccctgggaa ccgccctcct gattaaggcg tggcttctgc aggaatcccg gctccagagc     1920

aggaaattca gcccaccagc cacctcatcc ccaaccccct gtaaggttcc atccacccct     1980

gcgtcgagct gggaaggttc catgaagcga gtcgggtccc caacccgtgc ccctgggatc     2040

cgagggcccc tctccaagcg cctggctttg gaatgctcca ggcgcgccga cgcctgtgcc     2100

accccttcct cagcctgggg tttgaccacc cacctgacca ggggccctac ctggggaaag     2160

cctgaagggc ctcccagccc ccaaccccaa gaccaagctt agtcctggga gaggacaggg     2220

acttcgcaga ggcaagcgac cgaggccctc ccaaagaggc ccgccctgcc cgggctccca     2280

caccgtcagg tactcctgcc agggaactgg cctgctgcgc cccaggcccc gcccgtctct     2340

gctctgctca gctgcgcccc cttctttgca gctgcccagc ccctcctccc tgccctcggg     2400

tctccccacc tgcactccat ccagctacag gagagataga agcctctcgt cccgtccctc     2460

cctttcctcc gcctgtccac agccccttaa gggaaaggta ggaagagagg tccagccccc     2520

caggctgccc agagctgctg gtctcatttg ggggcgttcg ggaggtttgg ggggcatcaa     2580

ccccccgact gtgctgctcg cgaaggtccc acagccctga gatgggccgg cccccttcct     2640

ggcccctcat ggcgggactg gagaaatggt ccgctttcct ggagccaatg gcccggcccc     2700

tcctgactca tccgcctggc ccgggaatga atggggaggc cgctgaaccc acccggccca     2760

tatccctggt tgcctcatgg ccagcgcccc tcagcctctg ccactgtgaa ccggctccca     2820

ccctcaaggt gcggggagaa gaagcggcca ggcggggcgc cccaagagcc caaaagaggg     2880

cacaccgcca tcctctgcct caaattctgc gtttttggtt ttaatgttat atctgatgct     2940

gctatatcca ctgtccaacg gagttagacg aaaaaaaaaa aaaaaaaa                  2988


<210>  8
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Pro Leu Gly Tyr Phe Leu Leu Leu Cys Ser Leu Lys Gln Ala 
1               5                   10                  15      


Leu Gly Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr 
            20                  25                  30          


Ser Ser Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu 
        35                  40                  45              


Val Pro Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro 
    50                  55                  60                  


Ser Val Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln 
65                  70                  75                  80  


Phe Arg Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala 
                85                  90                  95      


Ile Phe Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val 
            100                 105                 110         


His Ala Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys 
        115                 120                 125             


Ala Glu Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly 
    130                 135                 140                 


Ser Pro Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu 
145                 150                 155                 160 


Phe Gly Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg 
                165                 170                 175     


Pro Asp Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg 
            180                 185                 190         


Gln Ala Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu 
        195                 200                 205             


Ser Gly Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe 
    210                 215                 220                 


Arg Ala Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu 
225                 230                 235                 240 


Met Val Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu 
                245                 250                 255     


Arg Pro Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val 
            260                 265                 270         


Tyr Tyr Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly 
        275                 280                 285             


Ser Phe Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile 
    290                 295                 300                 


Asp Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala 
305                 310                 315                 320 


Glu Arg Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr 
                325                 330                 335     


Val Ser Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
            340                 345                 350         


