                         SEQUENCE LISTING

<110>  The Scripps Research Institute
 
<120>  METHODS AND COMPOSITIONS FOR TREATING OCULAR VASCULAR DISORDERS

<130>  2030.0PC

<140>  PCT/US20/056469
<141>  2020-10-20

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Asp His Met Met Ala Met Asn His Gly Arg Phe Pro Asp Gly 
1               5                   10                  15      


Thr Asn Gly Leu His His His Pro Ala His Arg Met Gly Met Gly Gln 
            20                  25                  30          


Phe Pro Ser Pro His His His Gln Gln Gln Gln Pro Gln His Ala Phe 
        35                  40                  45              


Asn Ala Leu Met Gly Glu His Ile His Tyr Gly Ala Gly Asn Met Asn 
    50                  55                  60                  


Ala Thr Ser Gly Ile Arg His Ala Met Gly Pro Gly Thr Val Asn Gly 
65                  70                  75                  80  


Gly His Pro Pro Ser Ala Leu Ala Pro Ala Ala Arg Phe Asn Asn Ser 
                85                  90                  95      


Gln Phe Met Gly Pro Pro Val Ala Ser Gln Gly Gly Ser Leu Pro Ala 
            100                 105                 110         


Ser Met Gln Leu Gln Lys Leu Asn Asn Gln Tyr Phe Asn His His Pro 
        115                 120                 125             


Tyr Pro His Asn His Tyr Met Pro Asp Leu His Pro Ala Ala Gly His 
    130                 135                 140                 


Gln Met Asn Gly Thr Asn Gln His Phe Arg Asp Cys Asn Pro Lys His 
145                 150                 155                 160 


Ser Gly Gly Ser Ser Thr Pro Gly Gly Ser Gly Gly Ser Ser Thr Pro 
                165                 170                 175     


Gly Gly Ser Gly Ser Ser Ser Gly Gly Gly Ala Gly Ser Ser Asn Ser 
            180                 185                 190         


Gly Gly Gly Ser Gly Ser Gly Asn Met Pro Ala Ser Val Ala His Val 
        195                 200                 205             


Pro Ala Ala Met Leu Pro Pro Asn Val Ile Asp Thr Asp Phe Ile Asp 
    210                 215                 220                 


Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg Ile 
225                 230                 235                 240 


Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe Met 
                245                 250                 255     


Thr Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser Cys 
            260                 265                 270 


<210>  2
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg 
1               5                   10                  15      


Ile Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe 
            20                  25                  30          


<210>  3
<211>  54
<212>  PRT
<213>  Homo sapiens

<400>  3

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser 
    50                  


<210>  4
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  4

Gly Ser His Met Ser Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu 
1               5                   10                  15      


Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu 
            20                  25                  30          


Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp 
        35                  40                  45              


Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser 
    50                  55                  


<210>  5
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  5

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu 
            20                  25          


<210>  6
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  6

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu 
            20                  25                  30      


<210>  7
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  7

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe 
        35                  40                  


<210>  8
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  8

Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu Val Ile Glu Met 
1               5                   10                  15      


Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn 
            20                  25                  30          


Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln Gln Pro Ser Arg 
        35                  40                  45              


Val Ser 
    50  


<210>  9
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  9

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Lys Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser 
    50                  


<210>  10
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  10

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Pro Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser 
    50                  


<210>  11
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  11

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ala Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser 
    50                  


<210>  12
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  12

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Asp Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser 
    50                  


<210>  13
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  13

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Ala Pro Ala Ala Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser 
    50                  


<210>  14
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  14

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Pro Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Ala Pro Ala Ala Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser 
    50                  


<210>  15
<211>  65
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  15

Pro Lys Lys Lys Arg Lys Val Ser Ser Gly Ser Asn Val Ile Asp Thr 
1               5                   10                  15      


Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly 
            20                  25                  30          


Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu 
        35                  40                  45              


Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val 
    50                  55                  60                  


Ser 
65  


<210>  16
<211>  63
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  16

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser Ser Gly Pro Lys Lys Lys Arg Lys Val 
    50                  55                  60              


<210>  17
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  17

Gln Arg Lys Arg Gln Lys Ser Ser Gly Ser Asn Val Ile Asp Thr Asp 
1               5                   10                  15      


Phe Ile Asp Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu 
            20                  25                  30          


Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe 
        35                  40                  45              


Asp Phe Met Thr Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser 
    50                  55                  60                  


<210>  18
<211>  62
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  18

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser Ser Gly Gln Arg Lys Arg Gln Lys 
    50                  55                  60          


<210>  19
<211>  64
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  19

Glu Glu Lys Arg Lys Arg Ser Ser Gly Ser Asn Val Ile Asp Thr Asp 
1               5                   10                  15      


Phe Ile Asp Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu 
            20                  25                  30          


Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp Leu Gly Gln Asn Glu Phe 
        35                  40                  45              


Asp Phe Met Thr Asp Phe Val Cys Lys Gln Gln Pro Ser Arg Val Ser 
    50                  55                  60                  


<210>  20
<211>  62
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  20

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser Ser Gly Glu Glu Lys Arg Lys Arg 
    50                  55                  60          


<210>  21
<211>  68
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  21

Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly Ser Ser Gly Ser Asn Val 
1               5                   10                  15      


Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu Val Ile 
            20                  25                  30          


Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp Leu Gly 
        35                  40                  45              


Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln Gln Pro 
    50                  55                  60                  


Ser Arg Val Ser 
65              


<210>  22
<211>  66
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  22

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu Gly Gln Asn Glu Phe Asp Phe Met Thr Asp Phe Val Cys Lys Gln 
        35                  40                  45              


Gln Pro Ser Arg Val Ser Ser Gly Pro Gln Pro Lys Lys Lys Pro Leu 
    50                  55                  60                  


Asp Gly 
65      


<210>  23
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  23

Asn Val Ile Asp Thr Asp Phe Ile Asp Glu Glu Val Leu Met Ser Leu 
1               5                   10                  15      


Val Ile Glu Met Gly Leu Asp Arg Ile Lys Glu Leu Pro Glu Leu Trp 
            20                  25                  30          


Leu 
    


<210>  24
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  24

Gly Ser His Met Ser 
1               5   


<210>  25
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  25
ctgtgccagc tcagaacact g                                                 21


<210>  26
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  26
tgatcagccc gaaggagaag                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  27
aacgatgaag ccctggagt                                                    19


<210>  28
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  28
aggtttgatc cgcatgatct                                                   20


<210>  29
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  29
cgacaaagcc atcagtggtc tacg                                              24


<210>  30
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  30
gcagaaagta tccactgtga gtg                                               23


<210>  31
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  31
tggcttcatc tgcttgggca tg                                                22


<210>  32
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  32
gtcattggga ctcaggcggt tc                                                22


<210>  33
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  33
ggcactgacg cagacaag                                                     18


<210>  34
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  34
tgatcacctc gtaggcactg                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  35
agatctggca ccacaccttc                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  36
ggggtgttga aggtctcaaa                                                   20


<210>  37
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  37
cggccaggta cataggagga a                                                 21


<210>  38
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  38
cccccacttc tgagcttcac                                                   20


<210>  39
<211>  40
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  39
cccagaacct ctcaagtgcc cccagaacct ctcaagtgcc                             40


<210>  40
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  40
ctgcaacaga gcagttcagc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  41
ggctcgtcac cttcgtgaat                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  42
agaaaaggtt ggcagaggca                                                   20


<210>  43
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  43
gttcttcgca acctggcta                                                    19


<210>  44
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  44
tgagcttcat ccgagtcttc t                                                 21


<210>  45
<211>  19
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  45
tgcctgccca gtgggaatt                                                    19


<210>  46
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  46
tattggaagg gttcgtcgcc                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  47
gcactcaata cgaggcagtg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  48
ggcgatagtc gttagcttcg                                                   20


<210>  49
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  49
tcctcatcct gctgtccaag gt                                                22


<210>  50
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  50
attcgcctgg aggtagaaac cc                                                22


<210>  51
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is S, K, D, E, A, P, or phosphoSer.

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is  E, K or R.

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is D, E, I, L, M or W.

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is K or P.

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is E or P.

<400>  51

Asp Glu Glu Val Leu Met Xaa Leu Val Ile Xaa Met Gly Leu Xaa Arg 
1               5                   10                  15      


Ile Xaa Xaa 
            


<210>  52
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is F, Y, W, E or D.

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is I, F, W or Y.

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is S, K, D, E, A, P, or phosphoSer.

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is E, K or R.

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is D, E, I, L, M or W.

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is K or P.

<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is E or P.

<400>  52

Xaa Xaa Asp Glu Glu Val Leu Met Xaa Leu Val Ile Xaa Met Gly Leu 
1               5                   10                  15      


Xaa Arg Ile Xaa Xaa 
            20      


<210>  53
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  53

Asp Glu Glu Val Leu Met Ser Leu Val Ile Glu Met Gly Leu Asp Arg 
1               5                   10                  15      


Ile Lys Glu 
            


<210>  54
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  54

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  55
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  55

Gln Arg Lys Arg Gln Lys 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  56

Glu Glu Lys Arg Lys Arg 
1               5       


<210>  57
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  57

Pro Gln Pro Lys Lys Lys Pro Leu Asp Gly 
1               5                   10  


<210>  58
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  58

Ser Ser Gly Ser 
1               


<210>  59
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic sequence

<400>  59

Gly Ser His Met 
1               


